National Library of Energy BETA

Sample records for human radiation experiments

  1. Interim report of the Advisory Committee on human radiation experiments

    SciTech Connect (OSTI)

    Not Available

    1994-10-21

    The Advisory Committee on Human Radiation Experiments was created by President Clinton to advise the Human Radiation Interagency Working Group on the ethical and scientific criteria applicable to human radiation experiments carried out or sponsored by the U.S. Government. The Committee seeks to answer several fundamental question: What ethics criteria should be used to evaluate human radiation experiments? What was the Federal Government`s role in human radiation experiments? What are the criteria for determining appropriate Federal responses where wrongs or harms have occurred? What lessons learned from studying past and present research standards and practices should be applied to the future? The Committee has been gathering vast amounts of information and working to render it orderly and accessible. In the next six months, the Committee will continue with the tasks of data gathering and organizing. The focus of the work, however, will be developing criteria for judging historical and contemporary experiments, policies, and procedures, as well as criteria for remedies that may be appropriate where harms or wrongs have ocurred. Based on findings, the Committee will make specific recommendations regarding policies for the future.

  2. Advisory Committee on human radiation experiments final report

    SciTech Connect (OSTI)

    1995-10-01

    When the Advisory Committee began work in April 1994 we were charged with determining whether the radiation experiments design and administration adequately met the ethical and scientific standards, including standards of informed consent, that prevailed at the time of the experiments and that exist today and also to determine the ethical and scientific standards and criteria by which it shall evaluate human radiation experiments. Although this charge seems straightforward, it is in fact difficult to determine what the appropriate standards should be for evaluating the conduct and policies of thirty or fifty years ago. First, we needed to determine the extent to which the standards of that time are similar to the standards of today. To the extent that there were differences we needed to determine the relative roles of each in making moral evaluations. In Chapter 1 we report what we have been able to reconstruct about government rules and policies in the 1940s and 1950s regarding human experiments. We focus primarily on the Atomic Energy Commission and the Department of Defense. In Chapter 2 we turn from a consideration of government standards to an exploration of the norms and practices of physicians and medical scientists who conducted research with human subjects during this period. Using the results of our Ethics Oral History Project, and other sources, we also examine how scientists of the time viewed their moral responsibilities to human subjects as well as how this translated into the manner in which they conducted their research.

  3. Los Alamos Science: Number 23, 1995. Radiation protection and the human radiation experiments

    SciTech Connect (OSTI)

    Cooper, N.G.

    1995-12-31

    There are a variety of myths and misconceptions about the ionizing radiation that surrounds and penetrates us all. Dispel a few of these by taking a leisurely tour of radiation and its properties, of the natural and man-made sources of ionizing radiation, and of the way doses are calculated. By damaging DNA and inducing genetic mutations, ionizing radiation can potentially initiate a cell on the road to cancer. The authors review what is currently known about regulation of cellular reproduction, DNA damage and repair, cellular defense mechanisms, and the specific cancer-causing genes that are susceptible to ionizing radiation. A rapid survey of the data on radiation effects in humans shows that high radiation doses increase the risk of cancer, whereas the effects of low doses are very difficult to detect. The hypothetical risks at low doses, which are estimated from the atomic-bomb survivors, are compared to the low-dose data so that the reader can assess the present level of uncertainty. As part of the openness initiative, ten individuals who have worked with plutonium during various periods in the Laboratory`s history were asked to share their experiences including their accidental intakes. The history and prognosis of people who have had plutonium exposures is discussed by the Laboratory`s leading epidemiologist.

  4. Human radiation experiments associated with the US Department of Energy and its predecessors

    SciTech Connect (OSTI)

    None

    1995-07-01

    This document contains a listing, description, and selected references for documented human radiation experiments sponsored, supported, or performed by the US Department of Energy (DOE) or its predecessors, including the US Energy Research and Development Administration (ERDA), the US Atomic Energy Commission (AEC), the Manhattan Engineer District (MED), and the Off ice of Scientific Research and Development (OSRD). The list represents work completed by DOE`s Off ice of Human Radiation Experiments (OHRE) through June 1995. The experiment list is available on the Internet via a Home Page on the World Wide Web (http://www.ohre.doe.gov). The Home Page also includes the full text of Human Radiation Experiments. The Department of Energy Roadmap to the Story and the Records (DOE/EH-0445), published in February 1995, to which this publication is a supplement. This list includes experiments released at Secretary O`Leary`s June 1994 press conference, as well as additional studies identified during the 12 months that followed. Cross-references are provided for experiments originally released at the press conference; for experiments released as part of The DOE Roadmap; and for experiments published in the 1986 congressional report entitled American Nuclear Guinea Pigs: Three Decades of Radiation Experiments on US Citizens. An appendix of radiation terms is also provided.

  5. Advisory Committee on human radiation experiments. Supplemental Volume 2a, Sources and documentation appendices. Final report

    SciTech Connect (OSTI)

    1995-01-01

    This large document provides a catalog of the location of large numbers of reports pertaining to the charge of the Presidential Advisory Committee on Human Radiation Research and is arranged as a series of appendices. Titles of the appendices are Appendix A- Records at the Washington National Records Center Reviewed in Whole or Part by DoD Personnel or Advisory Committee Staff; Appendix B- Brief Descriptions of Records Accessions in the Advisory Committee on Human Radiation Experiments (ACHRE) Research Document Collection; Appendix C- Bibliography of Secondary Sources Used by ACHRE; Appendix D- Brief Descriptions of Human Radiation Experiments Identified by ACHRE, and Indexes; Appendix E- Documents Cited in the ACHRE Final Report and other Separately Described Materials from the ACHRE Document Collection; Appendix F- Schedule of Advisory Committee Meetings and Meeting Documentation; and Appendix G- Technology Note.

  6. L O S A L A M O S N A T I O N A L L A B O R A T O R Y Number 23 1995 Radiation Protection and the Human Radiation Experiments

    E-Print Network [OSTI]

    Massey, Thomas N.

    Protection and the Human Radiation Experiments #12;Harold Archuleta Nick Dallas Michael Martinez Art Beaumont today. In this volume on radiation protection and the human radiation experiments, these men share of our role in plutonium work. Jose Gonzales #12;Radiation Protection and the Human Radiation Experiments

  7. Human radiation experiments: The Department of Energy roadmap to the story and the records

    SciTech Connect (OSTI)

    Not Available

    1995-02-01

    The role of the US Government in conducting or sponsoring human radiation experiments has become the subject of public debate. Questions have been raised about the purpose, extent, and health consequences of these studies, and about how subjects were selected. The extent to which subjects provided informed consent is also under scrutiny. To respond to these questions, the Clinton administration has directed the US Department of Energy (DOE), along with other Federal agencies, to retrieve and inventory all records that document human radiation experiments. Many such records are now publicly available and will permit an open accounting and understanding of what took place. This report summarizes the Department`s ongoing search for records about human radiation experiments. It is also a roadmap to the large universe of pertinent DOE information. DOE is working to instill greater openness--consistent with national security and other appropriate considerations--throughout its operations. A key aspect of this effort is opening DOE`s historical records to independent research and analysis.

  8. Building public trust: Actions to respond to the report of the Advisory Committee on human radiation experiments

    SciTech Connect (OSTI)

    NONE

    1997-03-01

    Democratic government requires trust: people need to know and believe that the government is telling the truth. Without information about what the government is doing and why, citizens cannot exercise democratic control over government institutions. During his first year in office, President Clinton became concerned about reports that the government had conducted unethical secret human radiation experiments during the Cold War. To address this issue, in January 1994, President Clinton established the Advisory Committee on Human Radiation Experiments (ACHRE), chaired by bioethicist Dr. Ruth Faden of Johns Hopkins University. The President also directed all Federal agencies to search for records related to human subjects radiation research and provide them to the Advisory Committee. This report presents the Administration`s actions to respond to the ACHRE`s findings and recommendations.

  9. Advisory Committee on human radiation experiments. Final report, Supplemental Volume 2. Sources and documentation

    SciTech Connect (OSTI)

    NONE

    1995-01-01

    This volume and its appendixes supplement the Advisory Committee`s final report by reporting how we went about looking for information concerning human radiation experiments and intentional releases, a description of what we found and where we found it, and a finding aid for the information that we collected. This volume begins with an overview of federal records, including general descriptions of the types of records that have been useful and how the federal government handles these records. This is followed by an agency-by-agency account of the discovery process and descriptions of the records reviewed, together with instructions on how to obtain further information from those agencies. There is also a description of other sources of information that have been important, including institutional records, print resources, and nonprint media and interviews. The third part contains brief accounts of ACHRE`s two major contemporary survey projects (these are described in greater detail in the final report and another supplemental volume) and other research activities. The final section describes how the ACHRE information-nation collections were managed and the records that ACHRE created in the course of its work; this constitutes a general finding aid for the materials deposited with the National Archives. The appendices provide brief references to federal records reviewed, descriptions of the accessions that comprise the ACHRE Research Document Collection, and descriptions of the documents selected for individual treatment. Also included are an account of the documentation available for ACHRE meetings, brief abstracts of the almost 4,000 experiments individually described by ACHRE staff, a full bibliography of secondary sources used, and other information.

  10. Understanding Human Experience Henry Kautz

    E-Print Network [OSTI]

    Kautz, Henry

    Understanding Human Experience Henry Kautz One of the earliest goals of research in artificial intelligence was to create systems that can interpret and understand day to day human experience. Early work on the goal of building systems that understand human experience. Each of the previous barriers is weakened

  11. The Human Plutonium Injection Experiments William Moss and Roger Eckhardt

    E-Print Network [OSTI]

    Massey, Thomas N.

    that was pertinent to those and LouisHempelmann #12;similar radiation experi- ments with humans. This article177 The Human Plutonium Injection Experiments William Moss and Roger Eckhardt T he human plutonium injection experiments carried out during and after the Manhattan Project have received tremendous noto

  12. RADIATION CONTROL GUIDE 2/97 A-1 APPLICATION FOR THE NON-HUMAN USE OF RADIATION PRODUCING

    E-Print Network [OSTI]

    Slatton, Clint

    RADIATION CONTROL GUIDE 2/97 A-1 APPENDIX J APPLICATION FOR THE NON-HUMAN USE OF RADIATION _____ Formal X-RAY MACHINE OPERATING EXPERIENCE TYPE OF MACHINE LOCATION DATES USAGE Have radiation exposure PRODUCING DEVICES TO THE RADIATION CONTROL COMMITTEE 1. Principal Investigator

  13. New experiment on the neutron radiative decay

    E-Print Network [OSTI]

    Khafizov R. U.; Kolesnikov I. A.; Tolokonnikov S. V.; Torokhov V. D.; Solovei V. A.; Kolhidashvili M. R.; Konorov I. A

    2009-10-05

    The report is dedicated to the preparation of the new experiment on the neutron radiative decay what is conducted for the last years. We started the experimental research of this neutron decay branch with the experiment conducted at ILL in 2002 and continued in another experiment at the second and third cycles at the FRMII reactor of the Technical University of Munich in 2005. In the first experiment we succeeded in measuring only the upper limit on the relative intensity (B.R.) of the radiative neutron decay and in the second we succeeded in discovering events of radiative neutron decay and measure its B.R.=(3.2+-1.6)10-3 (with C.L.=99.7% and gamma quanta energy over 35 keV). The obtained average B.R. value was approximately twice the theoretical value calculated earlier within the framework of the standard electroweak model. However, due to significant experimental error it would be preliminary to deduce that based on this finding a deviation from the standard model has been observed. To prove or disprove the existence of a deviation it is necessary to conduct a new experiment that would allow to measure the radiative peak in timing spectra with precision in the order of 1%. By the present time we have prepared a new experiment the main result of which would be the measurement of B.R. for the radiative branch of neutron decay with this precision.

  14. Intrinsic radiation resistance in human chondrosarcoma cells

    SciTech Connect (OSTI)

    Moussavi-Harami, Farid [Departments of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242 (United States); Mollano, Anthony [Departments of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242 (United States); Martin, James A. [Departments of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242 (United States); Ayoob, Andrew [Departments of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242 (United States); Domann, Frederick E. [Department of Radiation Oncology, Iowa City, IA 52245 (United States); Gitelis, Steven [Department of Internal Medicine, Section of Medical Oncology, Chicago, IL 60612 (United States); Department of Orthopaedics Rush-Presbyterian St. Luke's Medical Center, Chicago, IL 60612 (United States); Buckwalter, Joseph A. [Departments of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA 52242 (United States)]. E-mail: joseph-buckwalter@uiowa.edu

    2006-07-28

    Human chondrosarcomas rarely respond to radiation treatment, limiting the options for eradication of these tumors. The basis of radiation resistance in chondrosarcomas remains obscure. In normal cells radiation induces DNA damage that leads to growth arrest or death. However, cells that lack cell cycle control mechanisms needed for these responses show intrinsic radiation resistance. In previous work, we identified immortalized human chondrosarcoma cell lines that lacked p16{sup ink4a}, one of the major tumor suppressor proteins that regulate the cell cycle. We hypothesized that the absence of p16{sup ink4a} contributes to the intrinsic radiation resistance of chondrosarcomas and that restoring p16{sup ink4a} expression would increase their radiation sensitivity. To test this we determined the effects of ectopic p16{sup ink4a} expression on chondrosarcoma cell resistance to low-dose {gamma}-irradiation (1-5 Gy). p16{sup ink4a} expression significantly increased radiation sensitivity in clonogenic assays. Apoptosis did not increase significantly with radiation and was unaffected by p16{sup ink4a} transduction of chondrosarcoma cells, indicating that mitotic catastrophe, rather than programmed cell death, was the predominant radiation effect. These results support the hypothesis that p16{sup ink4a} plays a role in the radiation resistance of chondrosarcoma cell lines and suggests that restoring p16 expression will improve the radiation sensitivity of human chondrosarcomas.

  15. Undulator Radiation Damage Experience at LCLS

    SciTech Connect (OSTI)

    Nuhn, H. D.; Field, C.; Mao, S.; Levashov, Y.; Santana, M.; Welch, J. N.; Wolf, Z.

    2015-01-06

    The SLAC National Accelerator Laboratory has been running the Linac Coherent Light Source (LCLS), the first x-ray Free Electron Laser since 2009. Undulator magnet damage from radiation, produced by the electron beam traveling through the 133-m long straight vacuum tube, has been and is a concern. A damage measurement experiment has been performed in 2007 in order to obtain dose versus damage calibrations. Radiation reduction and detection devices have been integrated into the LCLS undulator system. The accumulated radiation dose rate was continuously monitored and recorded. In addition, undulator segments have been routinely removed from the beamline to be checked for magnetic (50 ppm, rms) and mechanic (about 0.25 µm, rms) changes. A reduction in strength of the undulator segments is being observed, at a level, which is now clearly above the noise. Recently, potential sources for the observed integrated radiation levels have been investigated. The paper discusses the results of these investigation as well as comparison between observed damage and measured dose accumulations and discusses, briefly, strategies for the new LCLS-II upgrade, which will be operating at more than 300 times larger beam rate.

  16. From HumanFrom Human--Subject Experiments ToSubject Experiments To ComputationalComputational--Agent ExperimentsAgent Experiments

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    1 From HumanFrom Human--Subject Experiments ToSubject Experiments To Computational Experiments - 100% human 100% computational agents What is Agent-based Comp Econ (ACE)? - 100% computational://www.econ.iastate.edu/tesfatsi/aexper.htm #12;3 Spectrum of Possible Experiments 100% human Humans with computer access Human

  17. Human Portable Radiation Detection System Communications Package Evaluation

    SciTech Connect (OSTI)

    Morgen, Gerald P.; Peterson, William W.

    2009-06-11

    Testing and valuation of the Human Portable Radiation Detection System Communications Package for the US Coast Guard.

  18. From HumanFrom Human--Subject Experiments ToSubject Experiments To ComputationalComputational--Agent ExperimentsAgent Experiments

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    1 From HumanFrom Human--Subject Experiments ToSubject Experiments To Computational: ACE Electricity Market ACE Human-Subject (HS) Experiments Proof-of-Concept Proposal (GMUComputational--Agent ExperimentsAgent Experiments (And Everything In Between)(And Everything In Between) New Directions, IESA

  19. Stromal Modulation of Radiation Carcinogenesis in Breast Cancer

    E-Print Network [OSTI]

    Nguyen, David Hiendat Hua

    2011-01-01

    human exposures, we focused subsequent radiation-chimera experimentstumors of the radiation chimera experiments to human breastradiation chimera experiments and compares them to gene expression profiles of human

  20. Radiation experience with the CMS pixel detector

    E-Print Network [OSTI]

    Viktor Veszpremi; for the CMS Collaboration

    2014-12-09

    The CMS pixel detector is the innermost component of the CMS tracker occupying the region around the centre of CMS, where the LHC beams are crossed, between 4.3 cm and 30 cm in radius and 46.5 cm along the beam axis. It operates in a high-occupancy and high-radiation environment created by particle collisions. Studies of radiation damage effects to the sensors were performed throughout the first running period of the LHC. Leakage current, depletion voltage, pixel readout thresholds, and hit finding efficiencies were monitored as functions of the increasing particle fluence. The methods and results of these measurements will be described together with their implications to detector operation as well as to performance parameters in offline hit reconstruction.

  1. Status of the experiments on radiative branch of decay

    E-Print Network [OSTI]

    R. U. Khafizov; S. V. Tolokonnikov; V. A. Solovei; M. R. Kolhidashvili

    2009-03-09

    This report is dedicated to the investigation of radiative neutron decay. The theoretical spectrum of radiative gamma quanta, calculated within the framework of the standard electroweak interaction model, is compared with our experimental value of branching ratio (B.R.) for radiative neutron decay. It is noted that the study of radiative branches of elementary particle decay occupies a central place in the fundamental problem of searching for deviations from the standard electroweak model. Particular attention is paid to analyzing the results of the experiment conducted at the FRMII reactor of the Technical University of Munich in 2005.

  2. Radiative Corrections to the PREX and QWEAK Experiments

    SciTech Connect (OSTI)

    C. J. Horowitz

    2012-07-01

    The high precision parity violating electron scattering experiments PREX and QWEAK are sensitive to radiative corrections. In this paper we introduce the PREX experiment that measures the neutron radius of {sup 208}Pb and discuss coulomb distortion corrections. We then discuss dispersion corrections for QWEAK that aims to measure the weak charge of the proton.

  3. CERN 6 Tesla superconducting persistent dipole/Filming an experiment/Synchrotron radiation from protons

    E-Print Network [OSTI]

    1979-01-01

    CERN 6 Tesla superconducting persistent dipole/Filming an experiment/Synchrotron radiation from protons

  4. The Chaotic Nature of Human Experience: An Alternative Approach to Determinacy in Understanding Emotions and Experience

    E-Print Network [OSTI]

    Mutlu, Bilge

    The Chaotic Nature of Human Experience: An Alternative Approach to Determinacy in Understanding Nature of Human Experience: An Alternative Approach to Determinacy in Understanding Emotions and Experience Bilge Mutlu and Jodi Forlizzi School of Design & Human-Computer Interaction Institute, Carnegie

  5. Optical Transition Radiation Monitor for the T2K Experiment

    E-Print Network [OSTI]

    Sampa Bhadra; Mircea Cadabeschi; Patrick de Perio; Vyacheslav Galymov; Mark Hartz; Brian Kirby; Akira Konaka; Alysia D. Marino; John F. Martin; David Morris; Leif Stawnyczy

    2012-01-09

    An Optical Transition Radiation monitor has been developed for the proton beam-line of the T2K long base-line neutrino oscillation experiment. The monitor operates in the highly radioactive environment in proximity to the T2K target. It uses optical transition radiation, the light emitted from a thin metallic foil when the charged beam passes through it, to form a 2D image of a 30 GeV proton beam. One of its key features is an optical system capable of transporting the light over a large distance out of the harsh environment near the target to a lower radiation area where it is possible to operate a camera to capture this light. The monitor measures the proton beam position and width with a precision of better than 500 {\\mu}m, meeting the physics requirements of the T2K experiment.

  6. Low Background Radiation Experiment Yields Interesting Preliminary Results

    Office of Energy Efficiency and Renewable Energy (EERE)

    CARLSBAD, N.M., May 18, 2011 – New Mexico State University?s Low Background Radiation Experiment (LBRE), which takes place 2,150 feet below the earth?s surface at the Waste Isolation Pilot Plant, recently released some results about the project?s first two years of experimentation.

  7. RADIATION EXPOSURE TO HUMAN SUBJECTS, COMMITTEE ON The responsibilities of the Committee on Radiation Exposure to Human Subjects, established in 1974, are: 1) review

    E-Print Network [OSTI]

    Polz, Martin

    RADIATION EXPOSURE TO HUMAN SUBJECTS, COMMITTEE ON The responsibilities of the Committee on Radiation Exposure to Human Subjects, established in 1974, are: 1) review for authorization applications involving ionizing radiation exposure to human research subjects, insofar as the proposed study involves

  8. ARESE (ARM Enhanced Shortwave Experiment) Science Plan [Atmospheric Radiation Program

    SciTech Connect (OSTI)

    Valero, F.P.J.; Schwartz, S.E.; Cess, R.D.; Ramanathan, V.; Collins, W.D.; Minnis, P.; Ackerman, T.P.; Vitko, J.; Tooman, T.P.

    1995-09-27

    Several recent studies have indicated that cloudy atmospheres may absorb significantly more solar radiation than currently predicted by models. The magnitude of this excess atmospheric absorption, is about 50% more than currently predicted and would have major impact on our understanding of atmospheric heating. Incorporation of this excess heating into existing general circulation models also appears to ameliorate some significant shortcomings of these models, most notably a tendency to overpredict the amount of radiant energy going into the oceans and to underpredict the tropopause temperature. However, some earlier studies do not show this excess absorption and an underlying physical mechanism that would give rise to such absorption has yet to be defined. Given the importance of this issue, the Department of Energy's (DOE) Atmospheric Radiation Measurement (ARM) program is sponsoring the ARM Enhanced Shortwave Experiment (ARESE) to study the absorption of solar radiation by clear and cloudy atmospheres. The experimental results will be compared with model calculations. Measurements will be conducted using three aircraft platforms (ARM-UAV Egrett, NASA ER-2, and an instrumented Twin Otter), as well as satellites and the ARM central and extended facilities in North Central Oklahoma. The project will occur over a four week period beginning in late September, 1995. Spectral broadband, partial bandpass, and narrow bandpass (10nm) solar radiative fluxes will be measured at different altitudes and at the surface with the objective to determine directly the magnitude and spectral characteristics of the absorption of shortwave radiation by the atmosphere (clear and cloudy). Narrow spectral channels selected to coincide with absorption by liquid water and ice will help in identifying the process of absorption of radiation. Additionally, information such as water vapor profiles, aerosol optical depths, cloud structure and ozone profiles, needed to use as input in radiative transfer calculations, will be acquired using the aircraft and surface facilities available to ARESE. This document outlines the scientific approach and measurement requirements of the project.

  9. Direct determination of internal radiation dose in human blood

    E-Print Network [OSTI]

    Tan?r, Ayse Güne?

    2014-01-01

    The purpose of this study is to measure the internal radiation dose using a human blood sample. In the literature, there is no process that allows the direct measurement of the internal radiation dose received by a person. The luminescence counts from a blood sample having a laboratory-injected radiation dose and the waste blood of the patient injected with a radiopharmaceutical for diagnostic purposes were both measured. The decay and dose-response curves were plotted for the different doses. The doses received by the different blood aliquots can be determined by interpolating the luminescence counts to the dose-response curve. This study shows that the dose received by a person can be measured directly, simply and retrospectively by using only a very small amount of blood sample. The results will have important ramifications for the medicine and healthcare fields in particular. This will also be very important in cases of suspicion of radiation poisoning, malpractice and so on.

  10. Ionizing radiation predisposes non-malignant human mammary epithelial cells to undergo TGF beta-induced epithelial to mesenchymal transition

    E-Print Network [OSTI]

    2007-01-01

    Health Effects; the Low Dose Radiation Program of the DOElong-term, low-dose ionizing radiation exposure in humans.

  11. Human radiation studies: Remembering the early years. Oral history of Julie Langham Grilly, February 3, 1995

    SciTech Connect (OSTI)

    1995-09-01

    Julie Langham Grilly was interviewed by representatives of the US DOE Office of Human Radiation Experiments (OHRE) being the widow of Dr. Wright Langham, an investigator of principal interest of the committee. Her extensive experience with research at LANL was also of interest to the committee. Following a brief biographical sketch, Ms. Grilly relates her early postwar experience and her knowledge of Wright Langham`s involvement in animal research at Los Alamos, radiolanthanum tests on monkeys, Eniwetok tissue examinations, research on tritium uptake in humans, plutonium injections, tritium injections, EDTA, and etc. In addition to illuminating her former husband as a researcher and as an individual, she also relates her remembrances of Louis Hempelman, Enrico Fermi, Oppenheimer, Edward Teller, and many others.

  12. Direct determination of radiation dose in human blood

    E-Print Network [OSTI]

    Tanir, Ayse Gunes; Sahiner, Eren; Bolukdemir, Mustafa Hicabi; Koc, Kemal; Meric, Niyazi; Kelec, Sule Kaya

    2014-01-01

    Our purpose is to measure the internal radiation dose (ID) using human blood sample. In the literature, there is no process that allows the direct measurement of ID received by a person. This study has shown that it is possible to determine ID in human blood exposed to internal or external ionizing radiation treatment both directly and retrospectively. OSL technique was used to measure the total dose from the blood sample. OSL counts from the waste blood of the patient injected with a radiopharmaceutical for diagnostic or treatment purposes and from a blood sample having a laboratory-injected radiation dose were both used for measurements. The decay and dose-response curves (DRC) were plotted for different doses. The doses received by different blood aliquots have been determined by interpolating the natural luminescence counts to DRC. In addition, OSL counts from a healthy blood sample exposed to an external radiation source were measured. The blood aliquots were given different 0-200Gy beta doses and their ...

  13. Raman spectroscopy of single human tumour cells exposed to ionizing radiation in vitro This article has been downloaded from IOPscience. Please scroll down to see the full text article.

    E-Print Network [OSTI]

    Brolo, Alexandre G.

    Raman spectroscopy of single human tumour cells exposed to ionizing radiation in vitro This article tissue samples which will survive long enough in a lab to perform a radiation experiment. Animal in non-human systems to radiation therapy patient outcomes. As such, prescribed doses for tumour control

  14. The Performance of the Transition Radiation Detector of the AMS-02 experiment

    E-Print Network [OSTI]

    Roma "La Sapienza", Universitŕ di

    The Performance of the Transition Radiation Detector of the AMS-02 experiment Simonetta Gentile an indirect search of dark matter component of universe. A key element is a Transition Radiation Detector (TRD radiation detector, proton rejection. I. INTRODUCTION THE Alpha Magnetic Spectrometer is an experiment which

  15. Evaluation of commercial ADC radiation tolerance for accelerator experiments

    E-Print Network [OSTI]

    Kai Chen; Hucheng Chen; James Kierstead; Helio Takai; Sergio Rescia; Xueye Hu; Hao Xu; Joseph Mead; Francesco Lanni; Marena Minelli

    2015-05-08

    Electronic components used in high energy physics experiments are subjected to a radiation background composed of high energy hadrons, mesons and photons. These particles can induce permanent and transient effects that affect the normal device operation. Ionizing dose and displacement damage can cause chronic damage which disable the device permanently. Transient effects or single event effects are in general recoverable with time intervals that depend on the nature of the failure. The magnitude of these effects is technology dependent with feature size being one of the key parameters. Analog to digital converters are components that are frequently used in detector front end electronics, generally placed as close as possible to the sensing elements to maximize signal fidelity. We report on radiation effects tests conducted on 17 commercially available analog to digital converters and extensive single event effect measurements on specific twelve and fourteen bit ADCs that presented high tolerance to ionizing dose. Mitigation strategies for single event effects (SEE) are discussed for their use in the large hadron collider environment.

  16. THE BIOLOGICAL EFFECTS OF IONIZING RADIATION: EPIDEMIOLOGICAL SURVEYS AND LABORATORY ANIMAL EXPERIMENTS. IMPLICATIONS FOR RISK EVALUATION AND DECISION PROCESSES

    E-Print Network [OSTI]

    Fabrikant, J.I.

    2010-01-01

    human cancer risk from low radiation doses primarily frommodel for low-dose, low-LET radiation and carcinogenesis theis not observed at low radiation doses [ 1 9 ] . ships for

  17. Human radiation studies: Remembering the early years. Oral history of biophysicist Cornelius A. Tobias, Ph.D., January 16, 1995

    SciTech Connect (OSTI)

    1995-07-01

    Dr. Cornelius A. Tobias was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE). He was chosen for this interview because of his extensive biophysics and medical physics research activities while he was employed by the University of California, Berkeley and San Francisco and at the Donner Laboratory. He discusses his involvement in wartime studies of effects of high altitude on aviators, carbon monoxide with radioactive tracers, blood studies with radioactive iron, human use committees, heavy-ion research with the Bevatron, boron isotope research, classified research involving human subjects, heavy-particle radiography, heavy- particle beams and medical research, and pituitary irradiation studies,.

  18. REVERSE RADIATIVE SHOCK LASER EXPERIMENTS RELEVANT TO ACCRETING...

    Office of Scientific and Technical Information (OSTI)

    and radiative properties of a reverse shock relevant to a cataclysmic variable system. A reverse shock is a shock wave that develops when a freely flowing, supersonic...

  19. Experiment generates THz radiation 20,000 times brighter than...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    better characterization of semiconductors; and widening the frequency bands available for wireless communication. To produce, for the first time ever, intense terahertz radiation,...

  20. EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION

    E-Print Network [OSTI]

    Fabrikant, J.I.

    2010-01-01

    carcinogenic risk of low-dose, low-LET radiation is subjectcan be made for low-dose, low- LET radiation. Nevertheless,for radiation carcino­ Extrapolation to low doses. Radiation

  1. The effect of low dose ionizing radiation on homeostasis and functional integrity in an organotypic human skin model

    SciTech Connect (OSTI)

    von Neubeck, Claere; Geniza, Matthew; Kauer, Paula M.; Robinson, Joseph E.; Chrisler, William B.; Sowa, Marianne B.

    2015-05-01

    Outside the protection of earth’s atmosphere, astronauts are exposed to low doses of high linear energy transfer (LET) radiation. Future NASA plans for deep space missions or a permanent settlement on the moon are limited by the health risks associated with space radiation exposures. There is a paucity of direct epidemiological data for low dose exposures to space radiation-relevant high LET ions. Health risk models are used to estimate the risk for such exposures, though these models are based on high dose experiments. There is increasing evidence, however, that low and high dose exposures result in different signaling events at the molecular level, and may involve different response mechanisms. Further, despite their low abundance, high LET particles have been identified as the major contributor to health risk during manned space flight. The human skin is exposed in every external radiation scenario, making it an ideal epithelial tissue model in which to study radiation induced effects. Here, we exposed an in vitro three dimensional (3-D) human organotypic skin tissue model to low doses of high LET oxygen (O), silicon (Si) and iron (Fe) ions. We measured proliferation and differentiation profiles in the skin tissue and examined the integrity of the skin’s barrier function. We discuss the role of secondary particles in changing the proportion of cells receiving a radiation dose, emphasizing the possible impact on radiation-induced health issues in astronauts.

  2. The Chaotic Nature of Human Experience: Insights on the Subject Matter of Design towards

    E-Print Network [OSTI]

    Mutlu, Bilge

    The Chaotic Nature of Human Experience: Insights on the Subject Matter of Design towards," as Design has no fixed subject matter but the entire scope of human experience. I argue that human" of the subject matter of design that is #12;iv "human experience." My thesis essay is an attempt to explore

  3. Solar neutrinos radiative corrections in neutrino-electron scattering experiments

    E-Print Network [OSTI]

    Bahcall, J N; Sirlin, A; Bahcall, John N; Kamionkowski, Marc; Sirlin, Alberto

    1995-01-01

    Radiative corrections to the electron recoil-energy spectra and to total cross sections are computed for neutrino-electron scattering by solar neutrinos. Radiative corrections change monotonically the electron recoil spectrum for incident \\b8 neutrinos, with the relative probability of observing recoil electrons being reduced by about 4 \\% at the highest electron energies. For p-p and \\be7 neutrinos, the recoil spectra are not affected significantly. Total cross sections for solar neutrino-electron scattering are reduced by about 2 \\% compared to previously computed values. We also calculate the recoil spectra from ^{13}N and ^{15}O neutrinos including radiative corrections.

  4. Investigation of nanoscale thermal radiation : theory and experiments

    E-Print Network [OSTI]

    Narayanaswamy, Arvind

    2007-01-01

    The ability to control the radiative properties of objects is of prime importance in diverse areas like solar and thermophotovoltaic energy conversion, narrowband thermal emitters, and camouflage in military applications. ...

  5. A velocity map imaging spectrometer for electron?ion and ion?ion coincidence experiments with synchrotron radiation

    E-Print Network [OSTI]

    Rolles, D.; Advanced Light Source

    2008-01-01

    map imaging (VMI) spectrometer optimized for angle-resolved photoionization experiments with synchrotron radiation (map imaging spectrometer for electron-ion and ion-ion coincidence experiments with synchrotron radiation

  6. University Studies Diversity of Human Experience Note: In this scoring guide, "diversity" refers to differences in ethnic, religious, and

    E-Print Network [OSTI]

    University Studies Diversity of Human Experience Note: In this scoring guide, "diversity" refers within the broader context of human experience, demonstrating a sophisticated awareness · discusses personal experience within the broader context of human experience, demonstrating a working

  7. EPIDEMIOLOGICAL STUDIES ON RADIATION CARCINOGENESIS IN HUMAN POPULATIONS FOLLOWING ACUTE EXPOSURE: NUCLEAR EXPLOSIONS AND MEDICAL RADIATION

    E-Print Network [OSTI]

    Fabrikant, J.I.

    2010-01-01

    Implications for radio­ low doses: Radiation Res 71:61-74,effect of ological low-dose radiation in man, and surveyscarcinogenic of low-dose, low-LET radiation is subject to

  8. Radiation Protection lessonsRadiation Protection lessons Experiences with operating beams for

    E-Print Network [OSTI]

    McDonald, Kirk

    chamber. Less activation of l ll d d July 4, 20085 Nufact'08,Valencia, Spain g components, lower'rings in pumps and motors were not specified to be radiation resistant. CNGSCNGS only radiation hard components air.w . Effective air dehumidifier was installed ­ reduces the problem of corrosion considerably. July

  9. Experiments on humans Tomasz Ciesielski, Line-Kristin Larsen, Claudia Melis, Chia-Wei Vivian Wang

    E-Print Network [OSTI]

    Bech, Claus

    Experiments on humans Tomasz Ciesielski, Line-Kristin Larsen, Claudia Melis, Chia-Wei Vivian Wang #12;Experiments on humans - Foersřkdyrelćre ­ NTNU, November 2006 Page 1 of 21 Index 1. Historical issues and present status page 14 5. Behavioural research on humans page 15 5.1 The Milgram experiment

  10. Is the Human Amygdala Critical for the Subjective Experience of Emotion? Evidence of Intact Dispositional

    E-Print Network [OSTI]

    Toronto, University of

    Is the Human Amygdala Critical for the Subjective Experience of Emotion? Evidence of Intact & It is thought that the human amygdala is a critical component of the neural substrates of emotional experience experience following amygdala damage has been gathered in humans. In a preliminary test of the amygdala

  11. First Results from the Online Radiation Dose Monitoring System in ATLAS experiment

    E-Print Network [OSTI]

    Mandi?, I; The ATLAS collaboration; Deliyergiyev, M; Gorišek, A; Kramberger, G; Mikuž, M; Franz, S; Hartert, J; Dawson, I; Miyagawa, P S; Nicolas, L

    2011-01-01

    High radiation doses which will accumulate in components of ATLAS experiment during data taking will cause damage to detectors and readout electronics. It is therefore important to continuously monitor the doses to estimate the level of degradation caused by radiation. Online radiation monitoring system measures ionizing dose in SiO2 and fluences of 1-MeV(Si) equivalent neutrons and thermal neutrons at several locations in ATLAS detector. In this paper measurements collected during two years of ATLAS data taking are presented and compared to predictions from radiation background simulations.

  12. CRaTER: The Cosmic Ray Telescope for the Effects of Radiation Experiment on the Lunar Reconnaissance Orbiter Mission

    E-Print Network [OSTI]

    Spence, H. E.

    The Cosmic Ray Telescope for the Effects of Radiation (CRaTER) on the Lunar Reconnaissance Orbiter (LRO) characterizes the radiation environment to be experienced by humans during future lunar missions. CRaTER measures the ...

  13. ARM - Field Campaign - ARM West Antarctic Radiation Experiment - AWARE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail.Theory of rare Kaonforsupernovae2Gathering andNovember 16,Night ExperimentWest

  14. Dissociable substrates for body motion and physical experience in the human action

    E-Print Network [OSTI]

    Hamilton, Antonia

    Dissociable substrates for body motion and physical experience in the human action observation with a human present, regardless of training experience. Conversely, the right ventral premotor cortex responds temporal sulcus Abstract Observation of human actions recruits a well-defined network of brain regions, yet

  15. First Results from the Online Radiation Dose Monitoring System in ATLAS experiment

    E-Print Network [OSTI]

    Mandi?, I; The ATLAS collaboration; Deliyergiyev, M; Gorišek, A; Kramberger, G; Mikuž, M; Franz, S; Hartert, J; Dawson, I; Miyagawa, P; Nicolas, L

    2011-01-01

    High radiation doses which will accumulate in components of ATLAS experiment during data taking will causes damage to detectors and readout electronics. It is therefore important to continuously monitor the doses to estimate the level of degradation caused by radiation. Online radiation monitoring system measures ionizing dose in SiO2 , displacement damage in silicon in terms of 1-MeV(Si) equivalent neutron fluence and fluence of thermal neutrons at several locations in ATLAS detector. In this paper design of the system, results of measurements and comparison of measured integrated doses and fluences with predictions from FLUKA simulation will be shown.

  16. A practical experiment with interactive humanoid robots in a human society

    E-Print Network [OSTI]

    Kanda, Takayuki

    A practical experiment with interactive humanoid robots in a human society Takayuki Kanda1 a practical and long-term experiment with autonomous humanoid robots immersed in real human society. Students to identify individuals and adapt its behaviors to them. In this experiment, the robot spoke in English

  17. Two Experiments Comparing Reading with Listening for Human Processing of Conversational Telephone Speech

    E-Print Network [OSTI]

    Two Experiments Comparing Reading with Listening for Human Processing of Conversational Telephone of no experiment that directly compares Switchboard and Fishertype CTS transcripts with audio in terms of human. Abstract We report on results of two experiments designed to compare subjects' ability to extract

  18. God and the Human Experience A physicist's case for a theistic world view

    E-Print Network [OSTI]

    Gea-Banacloche, Julio

    God and the Human Experience A physicist's case for a theistic world view Julio Gea-Banacloche 1, starting from the basic facts about the human experience of existence. For convenience (but also, when they, in turn, experience the need to look beyond the simple conception of God that saw them

  19. Modeling and analysis of affective influences on human experience, prediction, decision making, and behavior

    E-Print Network [OSTI]

    Ahn, Hyungil, 1976-

    2010-01-01

    Subjective and affective elements are well-known to influence human decision making. This dissertation presents a theoretical and empirical framework on how human decision makers' subjective experience and affective ...

  20. Chromosomal changes in cultured human epithelial cells transformed by low- and high-LET radiation

    SciTech Connect (OSTI)

    Yang, Tracy Chui-hsu; Craise, L.M; Prioleau, J.C.; Stampfer, M.R.; Rhim, J.S.

    1990-11-01

    For a better assessment of radiation risk in space, an understanding of the responses of human cells, especially the epithelial cells, to low- and high-LET radiation is essential. In our laboratory, we have successfully developed techniques to study the neoplastic transformation of two human epithelial cell systems by ionizing radiation. These cell systems are human mammary epithelial cells (H184B5) and human epidermal keratinocytes (HEK). Both cell lines are immortal, anchorage dependent for growth, and nontumorigenic in athymic nude nice. Neoplastic transformation was achieved by irradiation cells successively. Our results showed that radiogenic cell transformation is a multistep process and that a single exposure of ionizing radiation can cause only one step of transformation. It requires, therefore, multihits to make human epithelial cells fully tumorigenic. Using a simple karyotyping method, we did chromosome analysis with cells cloned at various stages of transformation. We found no consistent large terminal deletion of chromosomes in radiation-induced transformants. Some changes of total number of chromosomes, however, were observed in the transformed cells. These transformants provide an unique opportunity for further genetic studies at a molecular level. 15 refs., 9 figs., 2 tabs.

  1. The rights, tensions, and ideas that inform the con-temporary human experience were explored by the

    E-Print Network [OSTI]

    The rights, tensions, and ideas that inform the con- temporary human experience were explored Trustee. Examining the Human Experience ANDREAKANE CLIFFMOORE #12;; and the conception and challenges of human rights from historical, philo- sophical, political, and sociological

  2. God and the human experience A physicist's case for a theistic world view

    E-Print Network [OSTI]

    Gea-Banacloche, Julio

    God and the human experience A physicist's case for a theistic world view Julio Gea-Banacloche 1 and--possibly--relate to that reality, by considering the various aspects of our (human beings') experience of existence. For convenience (but also with an ulterior theological purpose in mind

  3. Experiments investigating cooperative types in humans: A complement to evolutionary theory

    E-Print Network [OSTI]

    Dukas, Reuven

    Experiments investigating cooperative types in humans: A complement to evolutionary theory) Unlike other species, humans cooperate in large, distantly related groups, a fact that has long presented in humans remains a subject of vigorous debate. Results from theoretical analyses and agent

  4. Radiation Skyshine Calculation with MARS15 for the mu2e Experiment at Fermilab

    E-Print Network [OSTI]

    Leveling, A F

    2015-01-01

    The Fermilab Antiproton source is to be repurposed to provide an 8 kW proton beam to the Mu2e experiment by 1/3 integer, slow resonant extraction. Shielding provided by the existing facility must be supplemented with in-tunnel shielding to limit the radiation effective dose rate above the shield in the AP30 service building. In addition to the nominal radiation shield calculations, radiation skyshine calculations were required to ensure compliance with Fermilab Radiological Control Manual. A complete model of the slow resonant extraction system including magnets, electrostatic septa, magnetic fields, tunnel enclosure with shield, and a nearby exit stairway are included in the model. The skyshine model extends above the beam enclosure surface to 10 km vertically and 5 km radially.

  5. Quantitative Proteomic Profiling of Low Dose Ionizing Radiation Effects in a Human Skin Model

    SciTech Connect (OSTI)

    Hengel, Shawna; Aldrich, Joshua T.; Waters, Katrina M.; Pasa-Tolic, Ljiljana; Stenoien, David L.

    2014-07-29

    To assess molecular responses to low doses of radiation that may be encountered during medical diagnostic procedures, nuclear accidents, or terrorist acts, a quantitative global proteomic approach was used to identify protein alterations in a reconstituted human skin tissue treated with 10 cGy of ionizing radiation. Subcellular fractionation was employed to remove highly abundant structural proteins and provide insight on radiation induced alterations in protein abundance and localization. In addition, peptides were post-fractionated using high resolution 2-dimensional liquid chromatography to increase the dynamic range of detection of protein abundance and translocation changes. Quantitative data was obtained by labeling peptides with 8-plex isobaric iTRAQ tags. A total of 207 proteins were detected with statistically significant alterations in abundance and/or subcellular localization compared to sham irradiated tissues. Bioinformatics analysis of the data indicated that the top canonical pathways affected by low dose radiation are related to cellular metabolism. Among the proteins showing alterations in abundance, localization and proteolytic processing was the skin barrier protein filaggrin which is consistent with our previous observation that ionizing radiation alters profilaggrin processing with potential effects on skin barrier functions. In addition, a large number of proteases and protease regulators were affected by low dose radiation exposure indicating that altered proteolytic activity may be a hallmark of low dose radiation exposure. While several studies have demonstrated altered transcriptional regulation occurs following low dose radiation exposures, the data presented here indicates post-transcriptional regulation of protein abundance, localization, and proteolytic processing play an important role in regulating radiation responses in complex human tissues.

  6. Gravitational Hertz experiment with electromagnetic radiation in a strong magnetic field

    E-Print Network [OSTI]

    N. I. Kolosnitsyn; V. N. Rudenko

    2015-04-24

    Brief review of principal ideas in respect of the high frequency gravitational radiation generated and detected in the laboratory condition is presented. Interaction of electro-magnetic and gravitational waves into a strong magnetic field is considered as a more promising variant of the laboratory GW-Hertz experiment. The formulae of the direct and inverse Gertsenshtein-Zeldovich effect are derived. Numerical estimates are given and a discussion of a possibility of observation of these effects in a lab is carried out.

  7. The influence of microwave radiation on the state of chromatin in human cells

    E-Print Network [OSTI]

    Y. G. Shckorbatov; V. N. Pasiuga; V. A. Grabina; N. N. Kolchigin; D. O. Batrakov; V. V. Kalashnikov; D. D. Ivanchenko; V. N. Bykov

    2008-09-03

    Isolated human buccal epithelium cell were irradiated by microwaves at frequency f=35 GHz and surface power density E=30 mcW/cm2. The state of chromatin in human cells was determined by methodsof light and electron microscopy. The state of cell membranes was evaluated by the method of vital indigo carmine staining. The microwave-induced condensation of chromatin in human cells was revealed. Left side circulary polarized waves induced less effect than linearly polarized radiation. The linearly polarized electromagnetic waves induced cell membrane damage revealed by the increase of cell stainability. The data obtained are discussed in connection with the mechanisms of biologica effect of electromagnetic waves.

  8. Human In vivo Dose-Response to Controlled, Low-Dose Low Linear EnergyTransfer Ionizing Radiation Exposure

    E-Print Network [OSTI]

    Rocke, David M.

    Human In vivo Dose-Response to Controlled, Low-Dose Low Linear EnergyTransfer Ionizing Radiation Purpose: The effect of low doses of low ^ linear energy transfer (photon) ionizing radiation (LDIR, and pathway. Conclusions: These results show for the first time that low doses of radiation have an identifi

  9. Radiation and ionization energy loss simulation for the GDH sum rule experiment in Hall-A at Jefferson Lab

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yan, Xin -Hu; Ye, Yun -Xiu; Chen, Jian -Ping; Lu, Hai -Jiang; Zhu, Peng -Jia; Jiang, Feng -Jian

    2015-07-17

    The radiation and ionization energy loss are presented for single arm Monte Carlo simulation for the GDH sum rule experiment in Hall-A at Jefferson Lab. Radiation and ionization energy loss are discussed for $^{12}C$ elastic scattering simulation. The relative momentum ratio $\\frac{\\Delta p}{p}$ and $^{12}C$ elastic cross section are compared without and with radiation energy loss and a reasonable shape is obtained by the simulation. The total energy loss distribution is obtained, showing a Landau shape for $^{12}C$ elastic scattering. This simulation work will give good support for radiation correction analysis of the GDH sum rule experiment.

  10. Entrepreneurial experiments in science policy: Analyzing the Human Genome Project

    E-Print Network [OSTI]

    Huang, Kenneth G.

    We re-conceptualize the role of science policy makers, envisioning and illustrating their move from being simple investors in scientific projects to entrepreneurs who create the conditions for entrepreneurial experiments ...

  11. Bayesian inference of inaccuracies in radiation transport physics from inertial confinement fusion experiments

    E-Print Network [OSTI]

    Gaffney, Jim A; Sonnad, Vijay; Libby, Stephen B

    2013-01-01

    First principles microphysics models are essential to the design and analysis of high energy density physics experiments. Using experimental data to investigate the underlying physics is also essential, particularly when simulations and experiments are not consistent with each other. This is a difficult task, due to the large number of physical models that play a role, and due to the complex (and as a result, noisy) nature of the experiments. This results in a large number of parameters that make any inference a daunting task; it is also very important to consistently treat both experimental and prior understanding of the problem. In this paper we present a Bayesian method that includes both these effects, and allows the inference of a set of modifiers which have been constructed to give information about microphysics models from experimental data. We pay particular attention to radiation transport models. The inference takes into account a large set of experimental parameters and an estimate of the prior kno...

  12. Measuring the effects of online advertising on human behavior using natural and field experiments

    E-Print Network [OSTI]

    Lewis, Randall A. (Randall Aaron)

    2010-01-01

    This thesis investigates the effects of online advertising on human behavior: clicks, new-account sign-ups, and retail sales. Five chapters cover natural and field experiments used to measure these effects for both display ...

  13. Modelling of micromachining of human tooth enamel by erbium laser radiation

    SciTech Connect (OSTI)

    Belikov, A V; Skrypnik, A V; Shatilova, K V

    2014-08-31

    We consider a 3D cellular model of human tooth enamel and a photomechanical cellular model of enamel ablation by erbium laser radiation, taking into account the structural peculiarities of enamel, energy distribution in the laser beam cross section and attenuation of laser energy in biological tissue. The surface area of the texture in enamel is calculated after its micromachining by erbium laser radiation. The influence of the surface area on the bond strength of enamel with dental filling materials is discussed. A good correlation between the computer simulation of the total work of adhesion and experimentally measured bond strength between the dental filling material and the tooth enamel after its micromachining by means of YAG : Er laser radiation is attained. (laser biophotonics)

  14. Electroweak Radiative Corrections to the Parity-violating Asymmetry for SLAC Experiment E158

    SciTech Connect (OSTI)

    Zykunov, Vladimir A.; /Gomel State Tech. U.

    2012-04-04

    Electroweak radiative corrections to observable quantities of Moeller scattering of polarized particles are calculated. We emphasize the contribution induced by infrared divergent parts of cross section. The covariant method is used to remove infrared divergences, so that our results do not involve any unphysical parameters. When applied to the kinematics of SLAC E158 experiment, these corrections reduce the parity violating asymmetry by about -6.5% at E = 48 GeV and y = 0.5, and kinematically weighted 'hard' bremsstrahlung effect for SLAC E158 is {approx} 1%.

  15. Determining the radiative properties of pulverized-coal particles from experiments. Final report

    SciTech Connect (OSTI)

    Menguec, M.P.

    1992-02-01

    A comprehensive coupled experimental-theoretical study has been performed to determine the effective radiative properties of pulverized-coal/char particles. The results obtained show that the ``effective`` scattering phase function of coal particles are highly forward scattering and show less sensitivity to the size than predicted from the Lorenz-Mie theory. The main reason for this is the presence of smaller size particles associated with each larger particle. Also, the coal/char particle clouds display more side scattering than predicted for the same size range spheres, indicating the irregular shape of the particles and fragmentation. In addition to these, it was observed that in the visible wavelength range the coal absorption is not gray, and slightly vary with the wavelength. These two experimental approaches followed in this study are unique in a sense that the physics of the problem are not approximated. The properties determined include all uncertainties related to the particle shape, size distribution, inhomogeneity and spectral complex index of refraction data. In order to obtain radiative property data over a wider wavelength spectrum, additional ex-situ experiments have been carried out using a Fourier Transform Infrared (FT-IR) Spectrometer. The spectral measurements were performed over the wavelength range of 2 to 22 {mu}m. These results were interpreted to obtain the ``effective`` efficiency factors of coal particles and the corresponding refractive index values. The results clearly show that the coal/char radiative properties display significant wavelength dependency in the infrared spectrum.

  16. Human radiation studies: Remembering the early years: Oral history of radiologist Hymer L. Friedell, M.D., Ph.D., conducted January 28, 1995

    SciTech Connect (OSTI)

    Fisher, D.; Melamed, E.

    1995-07-01

    NThis report is a transcript of an interview with Hymer L. Friedell by representatives of the US DOE Office of Human Radiation Experiments. Dr. Friedell was selected for this interview because of his participation in the early stages of the medical use of radioisotopes, his important role in the Manhattan Engineer District Medical Division, and his distinguished medical career and his involvement in the distribution of isotopes and the approval for their use in humans. After a brief biographical sketch Dr. Friedell discusses his remembrances on a wide range of subjects. Topics discussed include pre-war radiation therapy, information provided to patients, the Army Medical Corps and the Manhattan Project, his work at the Chicago Metallurgical Laboratory, inspection visits of Manhattan Project facilities and proposed sites, Plutonium injection studies, and actions of the AEC Isotope Distribution Committee.

  17. Climate change will bring economic, social and environmental costs at scales beyond any other human experience (IARU, 2009). Studies imply that humanity

    E-Print Network [OSTI]

    Kammen, Daniel M.

    experience (IARU, 2009). Studies imply that humanity must reduce CO2 below its current atmosphericClimate change will bring economic, social and environmental costs at scales beyond any other human

  18. Primary Radiation Therapy for Head-and-Neck Cancer in the Setting of Human Immunodeficiency Virus

    SciTech Connect (OSTI)

    Klein, Emily A.; Guiou, Michael; Farwell, D. Gregory; Luu, Quang; Lau, Derick H.; Stuart, Kerri; Vaughan, Andrew; Vijayakumar, Srinivasan; Chen, Allen M.

    2011-01-01

    Purpose: To analyze outcomes after radiation therapy for head-and-neck cancer among a cohort of patients with human immunodeficiency virus (HIV). Methods and Materials: The medical records of 12 patients with serologic evidence of HIV who subsequently underwent radiation therapy to a median dose of 68 Gy (range, 64-72 Gy) for newly diagnosed squamous cell carcinoma of the head and neck were reviewed. Six patients (50%) received concurrent chemotherapy. Intensity-modulated radiotherapy was used in 6 cases (50%). All patients had a Karnofsky performance status of 80 or 90. Nine patients (75%) were receiving antiretroviral therapies at the time of treatment, and the median CD4 count was 460 (range, 266-800). Toxicity was graded according to the Radiation Therapy Oncology Group / European Organization for the Treatment of Cancer toxicity criteria. Results: The 3-year estimates of overall survival and local-regional control were 78% and 92%, respectively. Acute Grade 3+ toxicity occurred in 7 patients (58%), the most common being confluent mucositis (5 patients) and moist skin desquamation (4 patients). Two patients experienced greater than 10% weight loss, and none experienced more than 15% weight loss from baseline. Five patients (42%) experienced treatment breaks in excess of 10 cumulative days, although none required hospitalization. There were no treatment-related fatalities. Conclusions: Radiation therapy for head-and-neck cancer seems to be relatively well tolerated among appropriately selected patients with HIV. The observed rates of toxicity were comparable to historical controls without HIV.

  19. Loss of p53 protein during radiation transformation of primary human mammary epithelial cells

    SciTech Connect (OSTI)

    Wazer, D.E.; Chu, Qiuming; Liu, Xiao Long; Gao, Qingshen; Safaii, H.; Band, V. (Tufts Univ. School of Medicine, Boston, MA (United States))

    1994-04-01

    The causative factors leading to breast cancer are largely unknown. Increased incidence of breast cancer following diagnostic or therapeutic radiation suggests that radiation may contribute to mammary oncogenesis. This report describes the in vitro neoplastic transformation of a normal human mammary epithelial cell strain, 76N, by fractionated [gamma]-irradiation at a clinically used dose (30 Gy). The transformed cells (76R-30) were immortal, had reduced growth factor requirements, and produced tumors in nude mice. Remarkably, the 76R-30 cells completely lacked the p53 tumor suppressor protein. Loss of p53 was due to deletion of the gene on one allele and a 26-bp deletion within the third intron on the second allele which resulted in abnormal splicing out of either the third or fourth exon from the mRNA. PCR with a mutation-specific primer showed that intron 3 mutation was present in irradiated cells before selection for immortal phenotype. 76R-30 cells did not exhibit G[sub 1] arrest in response to radiation, indicating a loss of p53-mediated function. Expression of the wild-type p53 gene in 76R-30 cells led to their growth inhibition. Thus, loss of p53 protein appears to have contributed to neoplastic transformation of these cells. This unique model should facilitate analyses of molecular mechanisms of radiation-induced breast cancer and allow identification of p53-regulated cellular genes in breast cells. 44 refs., 8 figs., 1 tab.

  20. Digestibility of Human Foods and Animal Feeds as Measured by Experiments with Rats. 

    E-Print Network [OSTI]

    Fraps, G. S. (George Stronach)

    1945-01-01

    AND MECHANICAL COLLEGE OF TEXAS GIBB GILCHRIST, President [Blank Page in Original Bulletin] As part of the comprehensive investigation of the energy values of animal feeds and human foods, digestion experiments were made with white rats. Results of 508 tests... This publication is part of a comprehensive investigation of the energy values of animal feeds and human foods. Previous work has shown that the 1 differences in energy values of food and feeds as measured by experiments with chickens are due to a large extent...

  1. Performance of a radiatively cooled system for quantum optomechanical experiments in space

    E-Print Network [OSTI]

    Pilan-Zanoni, André; Johann, Ulrich; Aspelmeyer, Markus; Kaltenbaek, Rainer; Hechenblaikner, Gerald

    2015-01-01

    The performance of a radiatively cooled instrument is investigated in the context of optomechanical quantum experiments, where the environment of a macroscopic particle in a quantum-superposition has to be cooled to less than 20\\,K in deep space. A heat-transfer analysis between the components of the instrument as well as a transfer-function analysis on thermal oscillations induced by the spacecraft interior and by dissipative sources is performed. The thermal behaviour of the instrument in an orbit around a Lagrangian point and in a highly elliptical Earth orbit is discussed. Finally, we investigate further possible design improvements aiming at lower temperatures of the environment of the macroscopic particle. These include a mirror-based design of the imaging system on the optical bench and the extension of the heat shields.

  2. Human radiation studies: Remembering the early years: Oral history of cell biologist Don Francis Petersen, Ph.D., conducted November 29, 1994

    SciTech Connect (OSTI)

    1995-08-01

    This report is a transcript of an interview of Dr. Don Francis Petersen by representatives of the US DOE Office of Human Radiation Experiments. Dr. Petersen was selected for this interview because of his long research career at Los Alamos and his knowledge of the Atomic Energy Commission`s biomedical program. Dr. Petersen did not personally conduct research on human subjects. After a brief biographical sketch Dr. Petersen discusses his remembrances of the early use of radionuclides as biological tracers, aspects of nuclear weapons testing in the 1940`s and 1950`s including fallout studies, the means by which research projects were approved, use of humans in the whole-body counter, and the Health Division Biomedical responsibilities.

  3. Human radiation studies: Remembering the early years: Oral history of physician James S. Robertson, M.D., Ph.D., conducted January 20, 1995

    SciTech Connect (OSTI)

    1995-09-01

    This report is a transcript of in interview of Dr. James S. Robertson by representatives of the DOE Office of Human Radiation Experiments. Dr. Robertson was chosen for this interview because of his research at Brookhaven National Laboratory, especially on Boron Neutron Capture Therapy (BNCT); his work at the United States Naval Defense Laboratory; and his work at the Atomic Energy Commission. After a brief biographical sketch Dr. Robertson discusses research on human subjects at Berkeley, his contributions to the beginnings of Neutron Capture Therapy at Brookhaven, his participation with the Brookhaven Human Use Committee, his involvement in the study of the effects of Castle Bravo event on the Marshallese, and his work with the Naval Radiological Defense Laboratory.

  4. The Impact of Solar Particle Events on Radiation Risk for Human Explorers of Mars

    E-Print Network [OSTI]

    Gorguinpour, Camron Saul

    2010-01-01

    of Radiation Interaction and Matter and Detection. Worldof Radiation Interaction and Matter and Detection. WorldDetection Efficiency of Charged Particles and Electromagnetic radiation

  5. The Impact of Solar Particle Events on Radiation Risk for Human Explorers of Mars

    E-Print Network [OSTI]

    Gorguinpour, Camron Saul

    2010-01-01

    Rancoita. Principles of Radiation Interaction and Matter andRancoita. Principles of Radiation Interaction and Matter andThe basic measurement of radiation interaction in matter for

  6. INFORMATION SURFING FOR RADIATION MAP BUILDING

    E-Print Network [OSTI]

    Tanner, Herbert G.

    to envi- ronmental changes, as well as human retasking. Computer simulations and experiments are conducted radiation detectors do not provide any visual or statistical data map of the area in question. If humanINFORMATION SURFING FOR RADIATION MAP BUILDING R. A. Cortez , H. G. Tanner , R. Lumia , and C. T

  7. Talking about Tactile Experiences Marianna Obrist1

    E-Print Network [OSTI]

    Subramanian, Sriram

    experiences. We propose 14 categories for a human- experiential vocabulary based on the categorization mechanoreceptors. Author Keywords Tactile experiences; human-experiential vocabulary; user study; mechanoreceptors experiences [35]. For this study we used a haptic system to generate acoustic radiation pressures modulated

  8. A Study of How Products Contribute to the Emotional Aspects of Human Experience Jodi Forlizzi, Assistant Professor, HCII and School of Design

    E-Print Network [OSTI]

    Mutlu, Bilge

    A Study of How Products Contribute to the Emotional Aspects of Human Experience Author 1 Jodi to the Emotional Aspects of Human Experience Jodi Forlizzi, Bilge Mutlu, and Carl DiSalvo Human the emotional aspects of products is of interest for any field concerned with human experience. The vast amount

  9. Low Dose Radiation Response Curves, Networks and Pathways in Human Lymphoblastoid Cells Exposed from 1 to 10 cGy of Acute Gamma Radiation

    SciTech Connect (OSTI)

    Wyrobek, A. J.; Manohar, C. F.; Nelson, D. O.; Furtado, M. R.; Bhattacharya, M. S.; Marchetti, F.; Coleman, M.A.

    2011-04-18

    We investigated the low dose dependency of the transcriptional response of human cells to characterize the shape and biological functions associated with the dose response curve and to identify common and conserved functions of low dose expressed genes across cells and tissues. Human lymphoblastoid (HL) cells from two unrelated individuals were exposed to graded doses of radiation spanning the range of 1-10 cGy were analyzed by transcriptome profiling, qPCR and bioinformatics, in comparison to sham irradiated samples. A set of {approx}80 genes showed consistent responses in both cell lines; these genes were associated with homeostasis mechanisms (e.g., membrane signaling, molecule transport), subcellular locations (e.g., Golgi, and endoplasmic reticulum), and involved diverse signal transduction pathways. The majority of radiation-modulated genes had plateau-like responses across 1-10 cGy, some with suggestive evidence that transcription was modulated at doses below 1 cGy. MYC, FOS and TP53 were the major network nodes of the low-dose response in HL cells. Comparison our low dose expression findings in HL cells with those of prior studies in mouse brain after whole body exposure, in human keratinocyte cultures, and in endothelial cells cultures, indicates that certain components of the low dose radiation response are broadly conserved across cell types and tissues, independent of proliferation status.

  10. Development of a method for assessing non-targeted radiation damage in an artificial 3D human skin model

    E-Print Network [OSTI]

    Brenner, David Jonathan

    at doses as low as 0.1 Gy in the directly irradiated as well as in the bystander cells. Conclusions. #12;critical relevance in low-dose and/or non-Development of a method for assessing non-targeted radiation damage in an artificial 3D human skin

  11. Biochemical signatures of in vitro radiation response in human lung, breast and prostate tumour cells observed with Raman spectroscopy

    E-Print Network [OSTI]

    Brolo, Alexandre G.

    cells observed with Raman spectroscopy This article has been downloaded from IOPscience. Please scroll down to see the full text article. 2011 Phys. Med. Biol. 56 6839 (http://iopscience.iop.org/0031 signatures of in vitro radiation response in human lung, breast and prostate tumour cells observed with Raman

  12. Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away

    E-Print Network [OSTI]

    Brenner, David Jonathan

    in extrapolating radiation risk estimates from epidemi- ologically accessible doses down to very low doses where) and for assessing the risk from a low-dose exposure to a carcinogen such as ionizing radiation, where only a small, New York, NY 10032; Radiation Biology Laboratory, Research and Environmental Surveillance, Radiation

  13. RSSC ADMINISTRATIVE STRUCTURE OF RADIATION CONTROL PROGRAM 08/2011 1-35 1-36 RSSC ADMINISTRATIVE STRUCTURE OF RADIATION CONTROL PROGRAM 08/2011

    E-Print Network [OSTI]

    Slatton, Clint

    - nuclide Form Half- life Principal Radiation Activity Inventory Amount Activity Used Per Experiment OF RADIATION CONTROL PROGRAM 08/2011 1-39 APPLICATION FOR THE USE OF RADIOACTIVE MATERIALS IN HUMAN SUBJECTS TO THE HUMAN USE OF RADIOISOTOPES AND RADIATION COMMITTEE (HURRC) 1. Project Title: 2.

  14. ACHI 2012, The Fifth International Conference on Advances in Computer-Human Interactions, January 30 -February 4, 2012 -Valencia, Spain User Experience: Buzzword or New Paradigm?

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    the early days of ergonomics and HCI (Human- Computer Interaction), user experience really meant userACHI 2012, The Fifth International Conference on Advances in Computer-Human Interactions, January 30 - February 4, 2012 - Valencia, Spain User Experience: Buzzword

  15. We're here to celebrate our colleagues and our work--of increasing understanding of the human experience. We do

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    as the record of human experience isbroadanddeep,bothbypreservationandworktobringinto view elements that might acknowledged here, increase our understanding of the human experience and encourage us to reflect critically `thank you' for the wonderful humanities education that I received at UCSC." "My experience

  16. Comments to "Comparison of two experiments on radiative neutron decay" by R.U.Khafizov et al., published in Physics of Atomic Nuclei

    E-Print Network [OSTI]

    I. A. Kuznetsov

    2010-06-22

    Some critical comments and remarks on the article "Comparison of two experiments on radiative neutron decay" by R.U.Khafizov et al., published in Physics of Atomic Nuclei.

  17. Low Dose Radiation Response Curves, Networks and Pathways in Human Lymphoblastoid Cells Exposed from 1 to 10 cGy of Acute Gamma Radiation

    E-Print Network [OSTI]

    Wyrobek, A. J.

    2011-01-01

    Low Dose Radiation Response Curves, Networks and Pathways inbrain response to low- dose radiation exposure involves245-257. G. Bauer, Low dose radiation and intercellular

  18. Automatic Measurement of Radiation Dose Using an Autonomous Mobile Robot Two-Step Measurement Aimed to Accurately Measure in Wide Area, Short Time

    E-Print Network [OSTI]

    Ohya, Akihisa

    -- The purpose of the research is to create a radiation map. Radiation is harmful to the human body so we must avoid radiation as much as possible. A radiation map enables to avoid the high radiation point for human The experiment which finds average dose-of-radiation time 5.3 1 0.3m/s 50 100m 3 4 2 2 4 Fig. 4 0.3m/s 20m 4 Fig

  19. Atmospheric Radiation Measurment (ARM) Data from the Ganges Valley, India for the Ganges Valley Aerosol Experiment (GVAX)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    In 2011 and 2012, the Ganges Valley Aerosol Experiment (GVAX) began in the Ganges Valley region of India. The objective was to obtain measurements of clouds, precipitation, and complex aerosols to study their impact on cloud formation and monsoon activity in the region. During the Indian Ocean Experiment (INDOEX) field studies, aerosols from the Ganges Valley region were shown to affect cloud formation and monsoon activity over the Indian Ocean. The complex field study used the ARM Mobile Facility (AMF) to measure radiative, cloud, convection, and aerosol characteristics over the mainland. The resulting data set captured pre-monsoon to post-monsoon conditions to establish a comprehensive baseline for advancements in the study of the effects of atmospheric conditions of the Ganges Valley.

  20. High and Low Doses of Ionizing Radiation Induce Different Secretome Profiles in a Human Skin Model

    SciTech Connect (OSTI)

    Zhang, Qibin; Matzke, Melissa M.; Schepmoes, Athena A.; Moore, Ronald J.; Webb-Robertson, Bobbie-Jo M.; Hu, Zeping; Monroe, Matthew E.; Qian, Weijun; Smith, Richard D.; Morgan, William F.

    2014-03-18

    It is postulated that secreted soluble factors are important contributors of bystander effect and adaptive responses observed in low dose ionizing radiation. Using multidimensional liquid chromatography-mass spectrometry based proteomics, we quantified the changes of skin tissue secretome – the proteins secreted from a full thickness, reconstituted 3-dimensional skin tissue model 48 hr after exposure to 3, 10 and 200 cGy of X-rays. Overall, 135 proteins showed statistical significant difference between the sham (0 cGy) and any of the irradiated groups (3, 10 or 200 cGy) on the basis of Dunnett adjusted t-test; among these, 97 proteins showed a trend of downregulation and 9 proteins showed a trend of upregulation with increasing radiation dose. In addition, there were 21 and 8 proteins observed to have irregular trends with the 10 cGy irradiated group either having the highest or the lowest level among all three radiated doses. Moreover, two proteins, carboxypeptidase E and ubiquitin carboxyl-terminal hydrolase isozyme L1 were sensitive to ionizing radiation, but relatively independent of radiation dose. Conversely, proteasome activator complex subunit 2 protein appeared to be sensitive to the dose of radiation, as rapid upregulation of this protein was observed when radiation doses were increased from 3, to 10 or 200 cGy. These results suggest that different mechanisms of action exist at the secretome level for low and high doses of ionizing radiation.

  1. Parallax diagnostics of radiation source geometric dilution for iron opacity experiments

    SciTech Connect (OSTI)

    Nagayama, T.; Bailey, J. E.; Loisel, G.; Rochau, G. A.; Falcon, R. E. [Sandia National Laboratories, Albuquerque, New Mexico 87185 (United States)

    2014-11-15

    Experimental tests are in progress to evaluate the accuracy of the modeled iron opacity at solar interior conditions [J. E. Bailey et al., Phys. Plasmas 16, 058101 (2009)]. The iron sample is placed on top of the Sandia National Laboratories z-pinch dynamic hohlraum (ZPDH) radiation source. The samples are heated to 150–200 eV electron temperatures and 7× 10{sup 21}–4× 10{sup 22} cm{sup ?3} electron densities by the ZPDH radiation and backlit at its stagnation [T. Nagayama et al., Phys. Plasmas 21, 056502 (2014)]. The backlighter attenuated by the heated sample plasma is measured by four spectrometers along ±9° with respect to the z-pinch axis to infer the sample iron opacity. Here, we describe measurements of the source-to-sample distance that exploit the parallax of spectrometers that view the half-moon-shaped sample from ±9°. The measured sample temperature decreases with increased source-to-sample distance. This distance must be taken into account for understanding the sample heating.

  2. Radiation Treatment for Ewing Family of Tumors in Adults: University of Florida Experience

    SciTech Connect (OSTI)

    Shi Wenyin; Indelicato, Daniel J.; Keole, Sameer R.; Morris, Christopher G. [Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL (United States); Scarborough, Mark T.; Gibbs, Parker C. [Department of Orthopaedics and Rehabilitation, University of Florida College of Medicine, Gainesville, FL (United States); Zlotecki, Robert A. [Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL (United States)], E-mail: zlotera@ufl.edu

    2008-11-15

    Purpose: To review the clinical characteristics and outcomes of adult patients with Ewing family of tumors treated with radiation at University of Florida. Methods and Materials: Clinical features, treatment, and outcomes of 47 patients older than 18 years with Ewing family of tumors treated with combined radiation therapy and chemotherapy from 1970 to 2005 were retrospectively reviewed. Analysis was stratified by age older or younger than 30 years. Patients with metastatic disease at the time of diagnosis were excluded from the study. Results: The 29 men and 18 women had a median age of 24 years. Thirty-three patients were 18-30 years old and 14 patients were older than 30 years. Median follow-up of living patients was 8.2 years. The 5-year overall survival rate for all patients was 43% (p = 0.8523). The 5-year local control rate for all patients was 75% (p = 0.9326). The 5-year rate of freedom from distant metastasis for all patients was 45% (p = 0.5471). There were no significant differences in 5-year overall survival, local control, and freedom from distant metastasis rates; patterns of distant failure; or toxicity profiles between older adult patients and younger adult patients. Conclusions: We found that the natural history and treatment outcomes of the Ewing family of tumors were consistently similar in adults (young and old) and children. Thus, aggressive combined modality approaches should be considered for adult patients.

  3. Adjuvant Radiation Therapy and Survival for Pure Tubular Breast Carcinoma-Experience From the SEER Database

    SciTech Connect (OSTI)

    Li Baoqing, E-mail: bal9018@med.cornell.edu [Department of Radiation Oncology, Weill Cornell Medical College, New York, New York (United States); Chen, Margaret [Department of Surgery, Weill Cornell Medical College, New York, New York (United States)] [Department of Surgery, Weill Cornell Medical College, New York, New York (United States); Nori, Dattatreyudu; Chao, K.S. Clifford [Department of Radiation Oncology, Weill Cornell Medical College, New York, New York (United States)] [Department of Radiation Oncology, Weill Cornell Medical College, New York, New York (United States); Chen, Allen M. [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, California (United States)] [Department of Radiation Oncology, University of California Davis Cancer Center, Sacramento, California (United States); Chen, Steven L. [Department of Surgery, University of California Davis Cancer Center, Sacramento, California (United States)] [Department of Surgery, University of California Davis Cancer Center, Sacramento, California (United States)

    2012-09-01

    Purpose: Pure tubular carcinoma of the breast (PTCB) represents a distinct subtype of invasive ductal carcinoma (IDC) that is generally thought to be associated with better prognosis than even low-grade IDC. There has been controversy as to the role of adjuvant radiation therapy (RT) in this population. We hypothesized that adjuvant RT would demonstrate a survival improvement. Methods and Materials: We queried the Surveillance, Epidemiology and End Results database for the years 1992-2007 to identify patients with pure tubular carcinomas of the breast. Patient demographics, tumor characteristics, and surgical and RT treatments were collected. Survival analysis was performed using the Kaplan-Meier method for univariate comparisons and Cox proportional hazards modeling for multivariate comparisons, stratifying on the basis of age with a cutoff age of 65. Results: A total of 6465 patients were identified: 3624 (56.1%) patients underwent lumpectomy with RT (LUMP+RT), 1525 (23.6%) patients underwent lumpectomy alone (LUMP), 1266 (19.6%) patients received mastectomy alone (MAST), and 50 (0.8%) patients underwent mastectomy with RT (MAST+RT). When we compared the LUMP+RT and LUMP groups directly, those receiving adjuvant RT tended to be younger and were less likely to be hormone receptor-positive. Overall survival was 95% for LUMP+RT and 90% for LUMP patients at 5 years. For those 65 or younger, the absolute overall survival benefit of LUMP+RT over LUMP was 1% at 5 years and 3% at 10 years. On stratified multivariate analysis, adjuvant RT remained a significant predictor in both age groups (P=.003 in age {<=}65 and P=.04 in age >65 patients). Other significant unfavorable factors were older age and higher T stage (age >65 only). Conclusions: Since sufficiently powered large scale clinical trials are unlikely, we would recommend that adjuvant radiation be considered in PTCB patients age 65 or younger, although consideration of the small absolute survival benefit is important. Adjuvant radiation can be omitted for patients older than 65.

  4. LET dependence of radiation-induced bystander effects using human prostate tumor cells

    E-Print Network [OSTI]

    Anzenberg, Vered

    2008-01-01

    In the past fifteen years, evidence provided by many independent research groups have indicated higher numbers of cells exhibiting damage than expected based on the number of cells traversed by the radiation. This phenomenon ...

  5. The shock/shear platform for planar radiation-hydrodynamics experiments on the National Ignition Facility

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Doss, F. W.; Kline, J. L.; Flippo, K. A.; Perry, T. S.; DeVolder, B. G.; Tregillis, I.; Loomis, E. N.; Merritt, E. C.; Murphy, T. J.; Welser-Sherrill, L.; et al

    2015-04-17

    An indirectly-driven shock tube experiment fielded on the National Ignition Facility (NIF) was used to create a high-energy-density hydrodynamics platform at unprecedented scale. Scaling up a shear-induced mixing experiment previously fielded at OMEGA, the NIF shear platform drives 130 ?m/ns shocks into a CH foam-filled shock tube (~ 60 mg/cc) with interior dimensions of 1.5 mm diameter and 5 mm length. The pulse-shaping capabilities of the NIF are used to extend the drive for >10 ns, and the large interior tube volumes are used to isolate physics-altering edge effects from the region of interest. The scaling of the experiment tomore »the NIF allows for considerable improvement in maximum driving time of hydrodynamics, in fidelity of physics under examination, and in diagnostic clarity. Details of the experimental platform and post-shot simulations used in the analysis of the platform-qualifying data are presented. Hydrodynamic scaling is used to compare shear data from OMEGA with that from NIF, suggesting a possible change in the dimensionality of the instability at late times from one platform to the other.« less

  6. Correlation between radiation processes in silicon and long-time degradation of detectors for high energy physics experiments

    E-Print Network [OSTI]

    Sorina Lazanu; Ionel Lazanu

    2006-11-20

    In this contribution, the correlation between fundamental interaction processes induced by radiation in silicon and observable effects which limit the use of silicon detectors in high energy physics experiments is investigated in the frame of a phenomenological model which includes: generation of primary defects at irradiation starting from elementary interactions in silicon; kinetics of defects, effects at the p-n junction detector level. The effects due to irradiating particles (pions, protons, neutrons), to their flux, to the anisotropy of the threshold energy in silicon, to the impurity concentrations and resistivity of the starting material are investigated as time, fluence and temperature dependences of detector characteristics. The expected degradation of the electrical parameters of detectors in the complex hadron background fields at LHC & SLHC are predicted.

  7. Human-automation task allocation in lunar landing: simulation and experiments

    E-Print Network [OSTI]

    Wen, Hui Ying

    2011-01-01

    Task allocation, or how tasks are assigned to the human operator(s) versus to automation, is an important aspect of designing a complex vehicle or system for use in human space exploration. The performance implications of ...

  8. Human radiation studies: Remembering the early years. Oral history of radiologist Earl R. Miller, M.D., August 9 and 17, 1994

    SciTech Connect (OSTI)

    1995-06-01

    Dr. Earl R. Miller was interviewed by representatives of US DOE Office of Human Radiation Research (OHRE). The interview covers Dr. Miller`s involvement with the Manhattan Engineer District, with total body irradiation, and heavy-ion therapy. Dr. Miller`s remembrances include wartime work on radiation exposure, Joe Hamilton, Neutron Therapy research, means of obtaining isotopes, consent forms, infinite laminograms, invention of a baby holder to alleviate exposure of radiological technicians in diagnostic procedures involving infants, and several personages.

  9. Numerical analysis of radiation dynamics in a combined hohlraum in the X-ray opacity experiments on the 'Iskra-5' laser facility

    SciTech Connect (OSTI)

    Bondarenko, S V; Novikova, E A [Russian Federal Nuclear Center 'All-Russian Research Institute of Experimental Physics', Sarov, Nizhnii Novgorod region (Russian Federation); Dolgoleva, G V [M.V. Keldysh Institute for Applied Mathematics, Russian Academy of Sciences, Moscow (Russian Federation)

    2014-03-28

    We report the results of numerical analysis of radiation dynamics (laser absorption and X-ray generation) by using SNDLIRA code in a combined box used in the X-ray opacity measurements on the 'Iskra-5' facility (laser radiation wavelength, ? = 0.66 ?m; laser pulse duration, ?{sub 0.5} ? 0.6 ns; and energy, 900 J). Combined boxes used in these experiments comprised three sections: two illuminators delivering laser radiation and a central diagnostic section with a test sample. We have proposed a scheme for step-by-step calculation of the heating dynamics of the sample under study in a three-section hohlraum. Two designs of a combined box, which differ in the ways the laser radiation is injected, are discussed. It is shown that the axial injection of the beams results in intense secondary laser irradiation of the illuminator edge which leads to its partial disruption and penetration of laser radiation into the central diagnostic section. In this case the sample under study is exposed to additional uncontrolled action of scattered laser radiation. Such an undesirable action may be avoided by using the lateral injection of the beams through four holes on the lateral side of the illuminators. For the latter case we have calculated the heating dynamics for the sample and found an optimal time delay for an X-ray probe pulse. (interaction of laser radiation with matter. laser plasma)

  10. A hybrid approach to beam angle optimization in intensity-modulated radiation therapy

    E-Print Network [OSTI]

    Bertsimas, Dimitris

    Linear programming Computational experiments a b s t r a c t Intensity-Modulated Radiation Therapy Optimization) is an important problem and is today often based on human experience. In this context, we faceA hybrid approach to beam angle optimization in intensity-modulated radiation therapy D. Bertsimas

  11. The ALTEA/ALTEINO projects: studying functional effects of microgravity and cosmic radiation

    E-Print Network [OSTI]

    Morselli, Aldo

    for human neurophysiological, electrophysiological and psychophysics experiments, studies on particle fluxes experiments, while providing novel information on the radiation environment onboard the ISS and on the brainThe ALTEA/ALTEINO projects: studying functional effects of microgravity and cosmic radiation L

  12. Remote Measurement of Surface Compliance Distribution Using Ultrasound Radiation Pressure

    E-Print Network [OSTI]

    Shinoda, Hiroyuki

    . In the experiments, the distribution of the surface compliance comparable to the human skin was successfully measuredRemote Measurement of Surface Compliance Distribution Using Ultrasound Radiation Pressure Masahiro broadcasting. Our system is composed of an ultrasound phased array generating acoustic radiation pressure

  13. THE BIOLOGICAL EFFECTS OF IONIZING RADIATION: EPIDEMIOLOGICAL SURVEYS AND LABORATORY ANIMAL EXPERIMENTS. IMPLICATIONS FOR RISK EVALUATION AND DECISION PROCESSES

    E-Print Network [OSTI]

    Fabrikant, J.I.

    2010-01-01

    Protection. The Evaluation of Risks from Radiation. PergamonIMPLICATIONS FOR RISK EVALUATION AND DECISION PROCESSES -responsible for the evaluation of risks and for decision-

  14. THE NATIONAL CENTER FOR RADIOECOLOGY: A NETWORK OF EXCELLENCE FOR ENVIRONMENTAL AND HUMAN RADIATION RISK REDUCTION

    SciTech Connect (OSTI)

    Jannik, T.

    2013-01-09

    Radioecology in the United States can be traced back to the early 1950s when small research programs were established to address the fate and effects of radionuclides released in the environment from activities at nuclear facilities. These programs focused primarily on local environmental effects, but global radioactive fallout from nuclear weapons testing and the potential for larger scale local releases of radioisotopes resulted in major concerns about the threat, not only to humans, but to other species and to ecosystems that support all life. These concerns were shared by other countries and it was quickly recognized that a multi-disciplinary approach would be required to address and understand the implications of anthropogenic radioactivity in the environment. The management, clean-up and long-term monitoring of legacy wastes at Department of Energy (DOE), Department of Defense (DOD), and Nuclear Regulatory Commission (NRC)-regulated facilities continues to be of concern as long as nuclear operations continue. Research conducted through radioecology programs provides the credible scientific data needed for decision-making purposes. The current status of radioecology programs in the United States are: fragmented with little coordination to identify national strategies and direct programs; suffering from a steadily decreasing funding base; soon to be hampered by closure of key infrastructure; hampered by aging and retiring workforce (loss of technical expertise); and in need of training of young scientists to ensure continuation of the science (no formal graduate education program in radioecology remaining in the U.S.). With these concerns in mind, the Savannah River National Laboratory (SRNL) took the lead to establish the National Center for Radioecology (NCoRE) as a network of excellence of the remaining radioecology expertise in the United States. As part of the NCoRE mission, scientists at SRNL are working with six key partner universities to re-establish a graduate education training program for radioecology. Recently, NCoRE hosted a workshop to identify the immediate needs for science-driven discoveries, tool development and the generation of scientific data to support the legislative decision-making process for remediation strategies, long-term monitoring of radiologically-contaminated sites and protection of human health and the environment. Some of the immediate strategic research needs were identified in the fields of functional genomics for determining low-dose effects, improved low-level dosimetry, and mixed (radiological and chemical) contaminant studies. Longer term strategic research and tool development areas included development of radioecology case study sites, comprehensive decision-making tools, consequence response actions, and optimized scenario based ecosystem modeling. A summary of the NCoRE workshop findings related to waste management needs and priority areas will be presented in this paper.

  15. Major in Anything and be Pre-Radiation Science at NEBRASKA! Pre-Radiation Science is one of fifteen advising categories in Pre-Health indicating your interest in pursuing coursework to prepare for

    E-Print Network [OSTI]

    Deng, Bo

    of technologies, and human cadavers to provide you with an interactive learning experience. You can even applyPRE-HEALTH Major in Anything and be Pre-Radiation Science at NEBRASKA! Pre-Radiation Science is one, business, in the humanities, or even the arts? The options are HERE and the choice is YOURS! Why NEBRASKA

  16. Major in Anything and be Pre-Radiation Science at NEBRASKA! Pre-Radiation Science is one of sixteen advising categories in Pre-Health indicating your interest in pursuing coursework to prepare for

    E-Print Network [OSTI]

    Deng, Bo

    of technologies, and human cadavers to provide you with an interactive learning experience. You can even apply PRE-HEALTH Major in Anything and be Pre-Radiation Science at NEBRASKA! Pre-Radiation Science, engineering, business, humanities, or even the arts? The options are HERE and the choice is YOURS! Why

  17. Ideal Observers for Detecting Human Motion: Correspondence Noise

    E-Print Network [OSTI]

    HongJing Lo; Alan Yuille

    2011-01-01

    psychophysical experiments showed that human performance waspsychophysics experiments to determine how humans performedpsychophysical experiments which are consistent with humans

  18. Reduced Toxicity With Intensity Modulated Radiation Therapy (IMRT) for Desmoplastic Small Round Cell Tumor (DSRCT): An Update on the Whole Abdominopelvic Radiation Therapy (WAP-RT) Experience

    SciTech Connect (OSTI)

    Desai, Neil B.; Stein, Nicholas F.; LaQuaglia, Michael P.; Alektiar, Kaled M.; Kushner, Brian H.; Modak, Shakeel; Magnan, Heather M.; Goodman, Karyn; Wolden, Suzanne L.

    2013-01-01

    Purpose: Desmoplastic small round cell tumor (DSRCT) is a rare malignancy typically involving the peritoneum in young men. Whole abdominopelvic radiation therapy (WAP-RT) using conventional 2-dimensional (2D) radiation therapy (RT) is used to address local recurrence but has been limited by toxicity. Our objectives were to assess the benefit of intensity modulated radiation therapy (IMRT) on toxicity and to update the largest series on radiation for DSRCT. Methods and Materials: The records of 31 patients with DSRCT treated with WAP-RT (22 with 2D-RT and 9 with IMRT) between 1992 and 2011 were retrospectively reviewed. All received multi-agent chemotherapy and maximal surgical debulking followed by 30 Gy of WAP-RT. A further focal boost of 12 to 24 Gy was used in 12 cases. Boost RT and autologous stem cell transplantation were nearly exclusive to patients treated with 2D-RT. Toxicities were assessed with the Common Terminology Criteria for Adverse Events. Dosimetric analysis compared IMRT and simulated 2D-RT dose distributions. Results: Of 31 patients, 30 completed WAP-RT, with a median follow-up after RT of 19 months. Acute toxicity was reduced with IMRT versus 2D-RT: P=.04 for gastrointestinal toxicity of grade 2 or higher (33% vs 77%); P=.02 for grade 4 hematologic toxicity (33% vs 86%); P=.01 for rates of granulocyte colony-stimulating factor; and P=.04 for rates of platelet transfusion. Post treatment red blood cell and platelet transfusion rates were also reduced (P=.01). IMRT improved target homogeneity ([D05-D95]/D05 of 21% vs 46%) and resulted in a 21% mean bone dose reduction. Small bowel obstruction was the most common late toxicity (23% overall). Updated 3-year overall survival and progression-free survival rates were 50% and 24%, respectively. Overall survival was associated with distant metastasis at diagnosis on multivariate analysis. Most failures remained intraperitoneal (88%). Conclusions: IMRT for consolidative WAP-RT in DSRCT improves hematologic toxicity in particular. Although the long-term efficacy of current treatment options remains disappointing, the improved therapeutic index of IMRT may aid in generalizing its use and allowing the addition of novel approaches such as intraperitoneal immunotherapy.

  19. Plasma density from Cerenkov radiation, betatron oscillations, and beam steering in a plasma wakefield experiment at 30 GeV

    SciTech Connect (OSTI)

    Catravas, P.; Chattopadhyay, S.; Esarey, E.; Leemans, W.P.; Assmann, R.; Decker, F.-J.; Hogan, M.J.; Iverson, R.; Siemann, R.H.; Walz, D.; Whittum, D.; Blue, B.; Clayton, C.; Joshi, C.; Marsh, K.; Mori, W.B.; Wang, S.; Katsouleas, T.; Lee, S.; Muggli, P.

    2001-01-01

    A method for using Cerenkov radiation near atomic spectral lines to measure plasma source properties for plasma wakefield applications has been discussed and experimentally verified. Because the radiation co-propagates with the electron beam, the radiation samples the source properties exactly along the path of interest with perfect temporal synchronization. Observation wavelengths were chosen with respect to the atomic resonances of the plasma source, where the relative change in the index of refraction strongly affects the Cerenkov cone angle, and permits flexible diagnostic design. The Cerenkov spatial profiles were systematically studied for a Lithium heat pipe oven as a function of oven temperature and observation wavelength. Neutral densities and plasma densities were extracted from the measurements.

  20. Effects of Adenovirus-Mediated Delivery of the Human Hepatocyte Growth Factor Gene in Experimental Radiation-Induced Heart Disease

    SciTech Connect (OSTI)

    Hu Shunying; Chen Yundai; Li Libing; Chen Jinlong; Wu Bin; Zhou, Xiao; Zhi Guang; Li Qingfang; Wang Rongliang; Duan Haifeng; Guo Zikuan; Yang Yuefeng; Xiao Fengjun; Wang Hua; Wang Lisheng

    2009-12-01

    Purpose: Irradiation to the heart may lead to late cardiovascular complications. The purpose of this study was to investigate whether adenovirus-mediated delivery of the human hepatocyte growth factor gene could reduce post-irradiation damage of the rat heart and improve heart function. Methods and Materials: Twenty rats received single-dose irradiation of 20 Gy gamma ray locally to the heart and were randomized into two groups. Two weeks after irradiation, these two groups of rats received Ad-HGF or mock adenovirus vector intramyocardial injection, respectively. Another 10 rats served as sham-irradiated controls. At post-irradiation Day 120, myocardial perfusion was tested by myocardial contrast echocardiography with contrast agent injected intravenously. At post-irradiation Day 180, cardiac function was assessed using the Langendorff technique with an isolated working heart model, after which heart samples were collected for histological evaluation. Results: Myocardial blood flow was significantly improved in HGF-treated animals as measured by myocardial contrast echocardiography at post-irradiation Day 120 . At post-irradiation Day 180, cardiac function was significantly improved in the HGF group compared with mock vector group, as measured by left ventricular peak systolic pressure (58.80 +- 9.01 vs. 41.94 +- 6.65 mm Hg, p < 0.05), the maximum dP/dt (5634 +- 1303 vs. 1667 +- 304 mm Hg/s, p < 0.01), and the minimum dP/dt (3477 +- 1084 vs. 1566 +- 499 mm Hg/s, p < 0.05). Picrosirius red staining analysis also revealed a significant reduction of fibrosis in the HGF group. Conclusion: Based on the study findings, hepatocyte growth factor gene transfer can attenuate radiation-induced cardiac injury and can preserve cardiac function.

  1. Information Surfing for Radiation Map Building R. Andres Cortez, Herbert G. Tanner Senior Member, IEEE, Ron Lumia, Fellow, IEEE and Chaouki T. Abdallah

    E-Print Network [OSTI]

    , as well as human retasking. Computer simulations and experiments were conducted to verify the asymptotic containers at places such as ports of entry or cargo holds. Human operators using radiation detectors do1 Information Surfing for Radiation Map Building R. Andres Cortez, Herbert G. Tanner Senior Member

  2. Human energy

    E-Print Network [OSTI]

    Sawyer, Suzana

    2010-01-01

    This is the power of human energy that Chevron neverExperience the power of ‘‘Human Energy’’: S. Sawyer (&)s voice returns: ‘‘This is the power of human energy. ’’ In

  3. Regulation Of Nf=kb And Mnsod In Low Dose Radiation Induced Adaptive Protection Of Mouse And Human Skin Cells

    SciTech Connect (OSTI)

    Jian Li

    2012-11-07

    A sampling of publications resulting from this grant is provided. One is on the subject of NF-ÎşB-Mediated HER2 Overexpression in Radiation-Adaptive Resistance. Another is on NF-ÎşB-mediated adaptive resistance to ionizing radiation.

  4. Low dose radiation hypersensitivity and clustered DNA damages in human fibroblasts exposed to low dose and dose rate protons or 137CS y-rays

    SciTech Connect (OSTI)

    Bennett P. V.; Bennett, P.V.; Keszenman, D.J.; Johnson, A.M.; Sutherland, B.M.; Wilson, P.F.

    2013-05-14

    Effective radioprotection for human space travelers hinges upon understanding the individual properties of charged particles. A significant fraction of particle radiation astronauts will encounter in space exploratory missions will come from high energy protons in galactic cosmic radiation (GCR) and/or possible exposures to lower energy proton flux from solar particle events (SPEs). These potential exposures present major concerns for NASA and others, in planning and executing long term space exploratory missions. We recently reported cell survival and transformation (acquisition of anchorage-independent growth in soft agar) frequencies in apparently normal NFF-28 primary human fibroblasts exposed to 0-30 cGy of 50MeV, 100MeV (SPE-like), or 1000 MeV (GCR-like) monoenergetic protons. These were modeled after 1989 SPE energies at an SPE-like low dose-rate (LDR) of 1.65 cGy/min or high dose rate (HDR) of 33.3 cGy/min delivered at the NASA Space Radiation Laboratory (NSRL) at BNL.

  5. Correlation of radiation absorbed dose to the human thyroid using the FBX dosimeter and external probe techniques 

    E-Print Network [OSTI]

    Bateman, Sarah Caroline Louisa

    1986-01-01

    calculational dose response. 25 9 Counts per minute of "'I as obtained using a 1" x 1" Nal external probe bioassay system as a function of '"I activity present. 26 INTRODUCTION The objective of this research is to measure the radiation absorbed dose from... dosimeter system, the energy imparted by radiation causes the ferrous ions present in the solution to be converted to ferric ions, so that the number of iona converted is proportional to the radiation absorbed dose (Gu78a). However in the FBX dosimeter...

  6. Recent progress in the development of large area silica aerogel for use as RICH radiator in the Belle II experiment

    E-Print Network [OSTI]

    Tabata, Makoto; Kawai, Hideyuki; Nishida, Shohei; Sumiyoshi, Takayuki

    2014-01-01

    We report recent progress in the development of large-area hydrophobic silica aerogels for use as radiators in the aerogel-based ring-imaging Cherenkov (A-RICH) counter to be installed in the forward end cap of the Belle II detector, which is currently being upgraded at the High Energy Accelerator Research Organization (KEK), Japan. The production of approximately 450 aerogel tiles with refractive indices of either 1.045 or 1.055 was completed in May, 2014, and the tiles are now undergoing optical characterization. Installation of the aerogels was tested by installing them into a partial mock-up of the support structure.

  7. Recent progress in the development of large area silica aerogel for use as RICH radiator in the Belle II experiment

    E-Print Network [OSTI]

    Makoto Tabata; Ichiro Adachi; Hideyuki Kawai; Shohei Nishida; Takayuki Sumiyoshi

    2014-11-16

    We report recent progress in the development of large-area hydrophobic silica aerogels for use as radiators in the aerogel-based ring-imaging Cherenkov (A-RICH) counter to be installed in the forward end cap of the Belle II detector, which is currently being upgraded at the High Energy Accelerator Research Organization (KEK), Japan. The production of approximately 450 aerogel tiles with refractive indices of either 1.045 or 1.055 was completed in May, 2014, and the tiles are now undergoing optical characterization. Installation of the aerogels was tested by installing them into a partial mock-up of the support structure.

  8. Quantum Thought Experiments Can Define Nature

    E-Print Network [OSTI]

    Donald McCartor

    2007-02-20

    One would not think that thought experiments could matter to nature, for they are a humble human device. Yet quantum mechanics very naturally frames thought experiments (as distinct from precisely defining what exists). They exemplify the informing powers of radiation. Though based on wave functions that have time symmetry, these tableaux inevitably tell of irreversible behavior by nature. The paper sketches how John von Neumann's measurement theory fits into this and retells N. David Mermin's baseball story.

  9. The History of Human Impact on the Genus

    E-Print Network [OSTI]

    developed these con- cepts over thousands of years of human experience in the tropical Pacific IslandsThe History of Human Impact on the Genus Santalum in Hawai`i1 Mark Merlin Dan VanRavenswaay2 Abstract: Adaptive radiation of Santalum in the Hawaiian archipelago has provided these remote islands

  10. Silica aerogel radiator for use in the A-RICH system utilized in the Belle II experiment

    E-Print Network [OSTI]

    Makoto Tabata; Ichiro Adachi; Nao Hamada; Koji Hara; Toru Iijima; Shuichi Iwata; Hidekazu Kakuno; Hideyuki Kawai; Samo Korpar; Peter Križan; Tetsuro Kumita; Shohei Nishida; Satoru Ogawa; Rok Pestotnik; Luka Šantelj; Andrej Seljak; Takayuki Sumiyoshi; Elvedin Tahirovi?; Keisuke Yoshida; Yosuke Yusa

    2014-06-18

    This paper presents recent progress in the development and mass production of large-area hydrophobic silica aerogels for use as radiators in the aerogel-based ring-imaging Cherenkov (A-RICH) counter, which will be installed in the forward end cap of the Belle II detector. The proximity-focusing A-RICH system is especially designed to identify charged kaons and pions. The refractive index of the installed aerogel Cherenkov radiators is approximately 1.05, and we aim for a separation capability exceeding 4$\\sigma $ at momenta up to 4 GeV/$c$. Large-area aerogel tiles (over 18 $\\times $ 18 $\\times $ 2 cm$^3$) were first fabricated in test productions by pin drying in addition to conventional methods. We proposed to fill the large end-cap region (area 3.5 m$^2$) with 124 water-jet-trimmed fan-shaped dual-layer-focusing aerogel combinations of different refractive indices (1.045 and 1.055). Guided by the test production results, we decided to manufacture aerogels by the conventional method and are currently proceeding with mass production. In an electron beam test undertaken at the DESY, we confirmed that the $K$/$\\pi $ separation capability of a prototype A-RICH counter exceeded 4$\\sigma $ at 4 GeV/$c$.

  11. Silica aerogel radiator for use in the A-RICH system utilized in the Belle II experiment

    E-Print Network [OSTI]

    Tabata, Makoto; Hamada, Nao; Hara, Koji; Iijima, Toru; Iwata, Shuichi; Kakuno, Hidekazu; Kawai, Hideyuki; Korpar, Samo; Križan, Peter; Kumita, Tetsuro; Nishida, Shohei; Ogawa, Satoru; Pestotnik, Rok; Šantelj, Luka; Seljak, Andrej; Sumiyoshi, Takayuki; Tahirovi?, Elvedin; Yoshida, Keisuke; Yusa, Yosuke

    2014-01-01

    This paper presents recent progress in the development and mass production of large-area hydrophobic silica aerogels for use as radiators in the aerogel-based ring-imaging Cherenkov (A-RICH) counter, which will be installed in the forward end cap of the Belle II detector. The proximity-focusing A-RICH system is especially designed to identify charged kaons and pions. The refractive index of the installed aerogel Cherenkov radiators is approximately 1.05, and we aim for a separation capability exceeding 4$\\sigma $ at momenta up to 4 GeV/$c$. Large-area aerogel tiles (over 18 $\\times $ 18 $\\times $ 2 cm$^3$) were first fabricated in test productions by pin drying in addition to conventional methods. We proposed to fill the large end-cap region (area 3.5 m$^2$) with 124 water-jet-trimmed fan-shaped dual-layer-focusing aerogel combinations of different refractive indices (1.045 and 1.055). Guided by the test production results, we decided to manufacture aerogels by the conventional method and are currently procee...

  12. Sequential Causal Learning in Humans and Rats

    E-Print Network [OSTI]

    Lu, Hongjing; Rojas, Randall R.; Beckers, Tom; Yuille, Alan

    2008-01-01

    selection, to a human experiment that employed pretraining (group (white) in human experiment by Beckers et al. (2005).set used for the human experiments, we increased the

  13. Sequential Causal Learning in Humans and Rats

    E-Print Network [OSTI]

    Hongjing Lu; Randall R. Rojas; Tom Beckers; Alan Yuille

    2011-01-01

    selection, to a human experiment that employed pretraining (group (white) in human experiment by Beckers et al. (2005).set used for the human experiments, we increased the

  14. Operational Experience and Research Directions in Military Night Vision Equipment Chris Johnson,

    E-Print Network [OSTI]

    Johnson, Chris

    to the human eye. Living and man-made objects tend to emit radiation, for instance in the form of heatOperational Experience and Research Directions in Military Night Vision Equipment Chris Johnson resolution. A second area of interest focuses on detecting electro-magnetic radiation that is not visible

  15. The Microwave Air Yield Beam Experiment (MAYBE): measurement of GHz radiation for Ultra-High Energy Cosmic Rays detection

    E-Print Network [OSTI]

    M. Monasor; M. Bohacova; C. Bonifazi; G. Cataldi; S. Chemerisov; J. R. T. De Mello Neto; P. Facal San Luis; B. Fox; P. W. Gorham; C. Hojvat; N. Hollon; R. Meyhandan; L. C. Reyes; B. Rouille D'Orfeuil; E. M. Santos; J. Pochez; P. Privitera; H. Spinka; V. Verzi; C. Williams; J. Zhou

    2011-08-31

    We present first measurements by MAYBE of microwave emission from an electron beam induced air plasma, performed at the electron Van de Graaff facility of the Argonne National Laboratory. Coherent radio Cherenkov, a major background in a previous beam experiment, is not produced by the 3 MeV beam, which simplifies the interpretation of the data. Radio emission is studied over a wide range of frequencies between 3 and 12 GHz. This measurement provides further insight on microwave emission from extensive air showers as a novel detection technique for Ultra-High Energy Cosmic Rays.

  16. Atmospheric Radiation Measurement (ARM) Data from Steamboat Springs, Colorado, for the Storm Peak Laboratory Cloud Property Validation Experiment (STORMVEX)

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    In October 2010, the initial deployment of the second ARM Mobile Facility (AMF2) took place at Steamboat Springs, Colorado, for the Storm Peak Laboratory Cloud Property Validation Experiment (STORMVEX). The objective of this field campaign was to obtain data about liquid and mixed-phase clouds using AMF2 instruments in conjunction with Storm Peak Laboratory (located at an elevation of 3220 meters on Mt. Werner), a cloud and aerosol research facility operated by the Desert Research Institute. STORMVEX datasets are freely available for viewing and download. Users are asked to register with the ARM Archive; the user's email address is used from that time forward as the login name.

  17. A Challenge to Control Gravity via Applying Electromagnetic Low-Frequency Radiation - Theory and Proposed Model Experiments

    E-Print Network [OSTI]

    Julius Vanko; Miroslav Sukenik; Jozef Sima

    2007-05-29

    Including Vaidya metric into the model of Expansive Nondecelerative Universe allows to localize the energy of gravitational field. A term of effective gravitational range is introduced and classic Newton potential is substituted for Yukawa-type potential. It allows to allocate a typical frequency value to each gravitational field. Derived theoretical conclusions led us to investigate the effect of electromagnetic field with a precisely predetermined frequency and intensity on iron. We believe that under certain circumstances a decrease in iron gravitational mass should be observed. Two model experiments verifying the theoretical conclusions are proposed.

  18. Fallout: The experiences of a medical team in the care of a Marshallese population accidentally exposed to fallout radiation

    SciTech Connect (OSTI)

    Conard, R.A.

    1991-12-31

    This report presents an historical account of the experiences of the Brookhaven Medical team in the examination and treatment of the Marshallese people following their accidental exposure to radioactive fallout in 1954. This is the first time that a population has been heavily exposed to radioactive fallout, and even though this was a tragic mishap, the medical findings have provided valuable information for other accidents involving fallout such as the recent reactor accident at Chernobyl. Particularly important has been the unexpected importance of radioactive iodine in the fallout in producing thyroid abnormalities.

  19. Fallout: The experiences of a medical team in the care of a Marshallese population accidentally exposed to fallout radiation

    SciTech Connect (OSTI)

    Conard, R.A.

    1991-01-01

    This report presents an historical account of the experiences of the Brookhaven Medical team in the examination and treatment of the Marshallese people following their accidental exposure to radioactive fallout in 1954. This is the first time that a population has been heavily exposed to radioactive fallout, and even though this was a tragic mishap, the medical findings have provided valuable information for other accidents involving fallout such as the recent reactor accident at Chernobyl. Particularly important has been the unexpected importance of radioactive iodine in the fallout in producing thyroid abnormalities.

  20. The Role of Postoperative Radiation Therapy in the Treatment of Meningeal Hemangiopericytoma—Experience From the SEER Database

    SciTech Connect (OSTI)

    Stessin, Alexander M.; Sison, Cristina; Nieto, Jaime; Raifu, Muri; Li, Baoqing

    2013-03-01

    Purpose: The aim of this study was to examine the effect of postoperative radiation therapy (RT) on cause-specific survival in patients with meningeal hemangiopericytomas. Methods and Materials: The Surveillance, Epidemiology, and End Results database from 1990-2008 was queried for cases of surgically resected central nervous system hemangiopericytoma. Patient demographics, tumor location, and extent of resection were included in the analysis as covariates. The Kaplan-Meier product-limit method was used to analyze cause-specific survival. A Cox proportional hazards regression analysis was conducted to determine which factors were associated with cause-specific survival. Results: The mean follow-up time is 7.9 years (95 months). There were 76 patients included in the analysis, of these, 38 (50%) underwent gross total resection (GTR), whereas the other half underwent subtotal resection (STR). Postoperative RT was administered to 42% (16/38) of the patients in the GTR group and 50% (19/38) in the STR group. The 1-year, 10-year, and 20-year cause-specific survival rates were 99%, 75%, and 43%, respectively. On multivariate analysis, postoperative RT was associated with significantly better survival (HR = 0.269, 95% CI 0.084-0.862; P=.027), in particular for patients who underwent STR (HR = 0.088, 95% CI: 0.015-0.528; P<.008). Conclusions: In the absence of large prospective trials, the current clinical decision-making of hemangiopericytoma is mostly based on retrospective data. We recommend that postoperative RT be considered after subtotal resection for patients who could tolerate it. Based on the current literature, the practical approach is to deliver limited field RT to doses of 50-60 Gy while respecting the normal tissue tolerance. Further investigations are clearly needed to determine the optimal therapeutic strategy.

  1. The Impact of New Technologies on Radiation Oncology Events and Trends in the Past Decade: An Institutional Experience

    SciTech Connect (OSTI)

    Hunt, Margie A.; Pastrana, Gerri; Amols, Howard I.; Killen, Aileen; Alektiar, Kaled

    2012-11-15

    Purpose: To review the type and frequency of patient events from external-beam radiotherapy over a time period sufficiently long to encompass significant technology changes. Methods and Materials: Ten years of quality assurance records from January 2001 through December 2010 were retrospectively reviewed to determine the frequency of events affecting patient treatment from four radiation oncology process steps: simulation, treatment planning, data entry/transfer, and treatment delivery. Patient events were obtained from manual records and, from May 2007 onward, from an institution-wide database and reporting system. Events were classified according to process step of origination and segregated according to the most frequently observed event types. Events from the institution-wide database were evaluated to determine time trends. Results: The overall event rate was 0.93% per course of treatment, with a downward trend over time led by a decrease in treatment delivery events. The frequency of certain event types, particularly in planning and treatment delivery, changed significantly over the course of the study, reflecting technologic and process changes. Treatments involving some form of manual intervention carried an event risk four times higher than those relying heavily on computer-aided design and delivery. Conclusions: Although the overall event rate was low, areas for improvement were identified, including manual calculations and data entry, late-day treatments, and staff overreliance on computer systems. Reducing the incidence of pretreatment events is of particular importance because these were more likely to occur several times before detection and were associated with larger dosimetric impact. Further improvements in quality assurance systems and reporting are imperative, given the advent of electronic charting, increasing reliance on computer systems, and the potentially severe consequences that can arise from mistakes involving complex intensity-modulated or image-guided treatments.

  2. Gen. Tech. Rep. PSW-101 Berkeley, CA. Pacific Southwest Forest and Range Experiment Station, Forest Service, U.S. Department of Agriculture; 1987.

    E-Print Network [OSTI]

    without close human supervision. By the year 2000, the sensing instruments may work from radiation, tGen. Tech. Rep. PSW-101 Berkeley, CA. Pacific Southwest Forest and Range Experiment Station, Forest

  3. Experiments + Simulations = Better Nuclear Power Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Experiments + Simulations Better Nuclear Power Research Experiments Simulations Better Nuclear Power Research Atomic Level Simulations Enhance Characterization of Radiation...

  4. Albert Einstein College of Medicine Amendment to Non-human Use of Radioactive Material License

    E-Print Network [OSTI]

    Emmons, Scott

    RSO-2 Rev.0 Albert Einstein College of Medicine Amendment to Non-human Use of Radioactive Material Present Total Quantity (mCi) New Total Quantity (mCi) Max. Amount per Experiment (mCi) Chemical Form: If yes, please explain: 3. Radiation Protection: Check special equipment to be used to control radiation

  5. Climate change will bring economic, social and environmental costs at scales beyond any other human experience (IARU, 2009). Studies imply that humanity

    E-Print Network [OSTI]

    Kammen, Daniel M.

    Climate change will bring economic, social and environmental costs at scales beyond any other human dangerous climate change. On the other hand, it lacks ambition. Its instruments mostly rely on complicated Panel on Climate Change (IPCC) which shared the 2007 Nobel Peace Prize with former Vice President Al

  6. Nuclear Physics: Experiment Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerator and Experimental Schedule Beam Time Request Form Experiment Scheduling and General Information Radiation Budget Form (pdf) Interactive beam request form (for contact...

  7. ARM West Antarctic Radiation Experiment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsicloudden Documentation Data Management Facility009 ARM

  8. Humans, Robots and Market Crashes: A Laboratory Study ?

    E-Print Network [OSTI]

    Feldman, Todd; Friedman, Daniel

    2008-01-01

    Based Models and Human Subject Experiments. Handbook of Com-data from our experiments combining humans and robots, usingbetween laboratory experiment with human subjects and agent

  9. The National Center for Radioecology (NCoRE): A Network of Excellence for Environmental and Human Radiation Risk Reduction - 13365

    SciTech Connect (OSTI)

    Kuhne, W.W.; Jannik, G.T.; Farfan, E.B.; Knox, A.S.; Mayer, J.J.; Murray, A.M. [Savannah River National Laboratory, Savannah River Site, Aiken, SC 29808 (United States)] [Savannah River National Laboratory, Savannah River Site, Aiken, SC 29808 (United States)

    2013-07-01

    Radioecology in the United States can be traced back to the early 1950's when small research programs were established to address the fate and effects of radionuclides released in the environment from activities at nuclear facilities. These programs focused primarily on local environmental effects, but global radioactive fallout from nuclear weapons testing and the potential for larger scale local releases of radioisotopes resulted in major concerns about the threat, not only to humans, but to other species and to ecosystems that support all life. These concerns were shared by other countries and it was quickly recognized that a multi-disciplinary approach would be required to address and understand the implications of anthropogenic radioactivity in the environment. The management, clean-up and long-term monitoring of legacy wastes at Department of Energy (DOE), Department of Defense (DOD), and Nuclear Regulatory Commission (NRC)-regulated facilities continues to be of concern as long as nuclear operations continue. Research conducted through radioecology programs provides the credible scientific data needed for decision-making purposes. The current status of radioecology programs in the United States are: fragmented with little coordination to identify national strategies and direct programs; suffering from a steadily decreasing funding base; soon to be hampered by closure of key infrastructure; hampered by aging and retiring workforce (loss of technical expertise); and in need of training of young scientists to ensure continuation of the science (no formal graduate education program in radioecology remaining in the U.S.). With these concerns in mind, the Savannah River National Laboratory (SRNL) took the lead to establish the National Center for Radioecology (NCoRE) as a network of excellence of the remaining radioecology expertise in the United States. As part of the NCoRE mission, scientists at SRNL are working with six key partner universities to re-establish a graduate education training program for radioecology. Recently, NCoRE hosted a workshop to identify the immediate needs for science-driven discoveries, tool development and the generation of scientific data to support the legislative decision-making process for remediation strategies, long-term monitoring of radiologically- contaminated sites and protection of human health and the environment. Some of the immediate strategic research needs were identified in the fields of functional genomics for determining low-dose effects, improved low-level dosimetry, and mixed (radiological and chemical) contaminant studies. Longer term strategic research and tool development areas included development of radioecology case study sites, comprehensive decision-making tools, consequence response actions, and optimized scenario based ecosystem modeling. A summary of the NCoRE workshop findings related to waste management needs and priority areas will be presented in this paper. (authors)

  10. Radiation physics, biophysics, and radiation biology

    SciTech Connect (OSTI)

    Hall, E.J.; Zaider, M.

    1991-05-01

    Research at the Radiological Research Laboratory is a blend of physics, chemistry, and biology, involving research at the basic level with the admixture of a small proportion of pragmatic or applied research in support of radiation protection and/or radiotherapy. Current research topics include: oncogenic transformation assays, mutation studies involving interactions between radiation and environmental contaminants, isolation, characterization and sequencing of a human repair gene, characterization of a dominant transforming gene found in C3H 10T1/2 cells, characterize ab initio the interaction of DNA and radiation, refine estimates of the radiation quality factor Q, a new mechanistic model of oncogenesis showing the role of long-term low dose medium LET radiation, and time dependent modeling of radiation induced chromosome damage and subsequent repair or misrepair.

  11. Feasibility study on the use of polyallyldiglycol-carbonate cell dishes in TUNEL assay for alpha particle radiobiological experiments

    E-Print Network [OSTI]

    Yu, Peter K.N.

    particle 1. Introduction Ionizing radiation leads to production of reactive oxygen species in human cells particle radiobiological experiments K.F. Chan a , E.H.W. Yum a , C.K. Wan b , W.F. Fong c , K.N. Yu a be visually counted. Radiobiological experiments were carried out to induce DNA damages, with the Td

  12. Continuous Wave Terahertz Reflection Imaging of Human Colorectal Tissue

    E-Print Network [OSTI]

    Massachusetts at Lowell, University of

    Continuous Wave Terahertz Reflection Imaging of Human Colorectal Tissue Pallavi Doradlaa,b , Karim cooled silicon bolometer detector. Using polarizers in the experiment both co-polarized and cross the microwave and infrared regions of the spectrum. The high sensitivity of THz radiation to water concentration

  13. Studying the protein expression in human B lymphoblastoid cells exposed to 1.8-GHz (GSM) radiofrequency radiation (RFR) with protein microarray

    SciTech Connect (OSTI)

    Zhijian, Chen [Department of Environmental and Occupational Health, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang (China) [Department of Environmental and Occupational Health, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang (China); Institute of Environmental Health, Medical College, Zhejiang University, Hangzhou 310058, Zhejiang (China); Xiaoxue, Li [Institute of Environmental Health, Medical College, Zhejiang University, Hangzhou 310058, Zhejiang (China)] [Institute of Environmental Health, Medical College, Zhejiang University, Hangzhou 310058, Zhejiang (China); Wei, Zheng [Zhejiang International Travel Healthcare Center, 230 Zhonghezhong Road, Hangzhou 310003 (China)] [Zhejiang International Travel Healthcare Center, 230 Zhonghezhong Road, Hangzhou 310003 (China); Yezhen, Lu; Jianlin, Lou; Deqiang, Lu; Shijie, Chen; Lifen, Jin [Institute of Environmental Health, Medical College, Zhejiang University, Hangzhou 310058, Zhejiang (China)] [Institute of Environmental Health, Medical College, Zhejiang University, Hangzhou 310058, Zhejiang (China); Jiliang, He, E-mail: he_jiliang@hotmail.com [Institute of Environmental Health, Medical College, Zhejiang University, Hangzhou 310058, Zhejiang (China)] [Institute of Environmental Health, Medical College, Zhejiang University, Hangzhou 310058, Zhejiang (China)

    2013-03-29

    Highlights: ? Protein microarray shows the differential expression of 27 proteins induced by RFR. ? RPA32 related to DNA repair is down-regulated in Western blot. ? p73 related to cell genome stability and apoptosis is up-regulated in Western blot. -- Abstract: In the present study, the protein microarray was used to investigate the protein expression in human B-cell lymphoblastoid cells intermittently exposed to 1.8-GHz GSM radiofrequency radiation (RFR) at the specific absorption rate (SAR) of 2.0 W/kg for 24 h. The differential expression of 27 proteins was found, which were related to DNA damage repair, apoptosis, oncogenesis, cell cycle and proliferation (ratio >1.5-fold, P < 0.05). The results validated with Western blot assay indicated that the expression of RPA32 was significantly down-regulated (P < 0.05) while the expression of p73 was significantly up-regulated in RFR exposure group (P < 0.05). Because of the crucial roles of those proteins in DNA repair and cell apoptosis, the results of present investigation may explain the biological effects of RFR on DNA damage/repair and cell apoptosis.

  14. HELLE: Health Effects of Low Level Exposures/ Gezondheidseffecten van lage blootstellingniveaus [International workshop: Influence of low level exposures to chemicals and radiation on human and ecological health

    SciTech Connect (OSTI)

    Schoten, Eert

    1998-11-26

    The Health Council is closely involved in establishing the scientific foundation of exposure limits for substances and radiation in order to protect public health. Through the years, the Council has contributed to the formulation of principles and procedures, both for carcinogenic and for noncarcinogenic agents. As a rule, the discussion with regard to the derivation of health-based recommended exposure limits centers around the appropriateness of extrapolation methods (What can be inferred from data on high exposure levels and on experimental animals?). Generally speaking, there is a lack of direct information on the health effects of low levels of exposure. Effects at these levels cannot usually be detected by means of traditional animal experiments or epidemiological research. The capacity of these analytical instruments to distinguish between ''signal'' and ''noise'' is inadequate in most cases. Annex B of this report contains a brief outline of the difficulties and the established methods for tackling this problem. In spite of this, the hope exists that the posited weak signals, if they are indeed present, can be detected by other means. The search will have to take place on a deeper level. In other words, effort must be made to discover what occurs at underlying levels of biological organization when organisms are exposed to low doses of radiation or substances. Molecular and cell biology provide various methods and techniques which give an insight into the processes within the cell. This results in an increase in the knowledge about the molecular and cellular effects of exposure to agents, or stated differently, the working mechanisms which form the basis of the health effects. Last year, the Health Council considered that the time was ripe to take stock of the state of knowledge in this field. To this end, an international working conference was held from 19 to 21 October 1997, entitled ''Health Effects of Low Level Exposures: Scientific Developments and Perspectives for Risk Assessment''. The central question was the extent to which the sometimes fast-growing knowledge about molecular and cellular effects offers the desired basis for extrapolation. Against this setting, a number of more specific questions which have been hotly debated for some time were also addressed. One of the primary questions concerned the traditional but increasingly questioned division between stochastic and non-stochastic working agents, and the corresponding division between exposure-effect relations without a threshold and with a threshold. Thoughts were also exchanged on what is often referred to as hormesis: the notion that low levels of exposure could actually improve health. For the purpose of illuminating the many aspects of these issues, experts from a number of areas were invited. In addition to this, three agents were selected to serve as points of crystallization for the general debate: ionizing radiation, ultraviolet (UV) radiation and dioxins. The present report calls attention to a selection of issues which emerged during the discussions on the above-mentioned central topic. Various more detailed questions and the wider context of the points considered are described at greater length in the enclosed conference report and in the background documents attached to the report. What follows is a series of considerations regarding the scientific basis for the derivation of recommended exposure levels, viewed in the light of current procedures and against the background of the work of the Health Council. In the preparation of the following comments and recommendations, various Dutch experts have been consulted.

  15. High-Resolution in Vivo Footprinting of a Protein-DNA Complex Using -Radiation

    E-Print Network [OSTI]

    Tullius, Thomas D.

    High-Resolution in Vivo Footprinting of a Protein-DNA Complex Using -Radiation Lori M. Ottinger prospect of the sequencing of the human genome has focused attention on how the information encoded in DNA experiment1 gives a direct "image" of which DNA sites are occupied by protein and which are empty

  16. Can biophysics tell us something about the weak equivalence principle vis a vis the thought experiment of Einstein involving human subjects?

    E-Print Network [OSTI]

    Fred H. Thaheld

    2009-06-16

    Over a period of several decades it has been noticed that most astronauts, either orbiting the earth or on trips to the moon, have observed phosphenes or light flashes (LF) including streaks, spots and clouds of light when their eyes are closed or they are in a darkened cabin. Scientists suspect that two separate components of cosmic rays cause these flashes due to direct interaction with the retina. This phenomenon is not noticed on the ground because of cosmic ray interaction with the atmosphere. The argument is advanced that this effect may provide us with a new method of exploring the weak equivalence principle from the standpoint of Einstein's original thought experiment involving human subjects. This can be done, utilizing the retina only, as an animate quantum mechanical measuring device or, in conjunction with the Anomalous Long Term Effects on Astronauts (ALTEA) facility.

  17. ,FebrUary 1991 Radiation Protection

    E-Print Network [OSTI]

    Rathbun, Julie A.

    -N-ASA _Technical Paper _3079 ,FebrUary 1991 Radiation Protection for Human Missions to the Moon Division Radiation Protection for Human Missions to the Moon and Mars Lisa C. Simonsen and John E. Nealy Langley Research Center Hampton, Virginia #12;#12;Summary Radiation protection assessments are performed

  18. Remote Sensing and In-Situ Observations of Arctic Mixed-Phase and Cirrus Clouds Acquired During Mixed-Phase Arctic Cloud Experiment: Atmospheric Radiation Measurement Uninhabited Aerospace Vehicle Participation

    SciTech Connect (OSTI)

    McFarquhar, G.M.; Freer, M.; Um, J.; McCoy, R.; Bolton, W.

    2005-03-18

    The Atmospheric Radiation Monitor (ARM) uninhabited aerospace vehicle (UAV) program aims to develop measurement techniques and instruments suitable for a new class of high altitude, long endurance UAVs while supporting the climate community with valuable data sets. Using the Scaled Composites Proteus aircraft, ARM UAV participated in Mixed-Phase Arctic Cloud Experiment (M-PACE), obtaining unique data to help understand the interaction of clouds with solar and infrared radiation. Many measurements obtained using the Proteus were coincident with in-situ observations made by the UND Citation. Data from M-PACE are needed to understand interactions between clouds, the atmosphere and ocean in the Arctic, critical interactions given large-scale models suggest enhanced warming compared to lower latitudes is occurring.

  19. Radiation: Radiation Control (Indiana)

    Broader source: Energy.gov [DOE]

    It is the policy of the state to encourage the constructive uses of radiation and to control its harmful effects. This section contains regulations pertaining to the manufacture, use,...

  20. Simulations of MATROSHKA experiments at ISS using PHITS

    E-Print Network [OSTI]

    Sihver, L; Puchalska, M; Reitz, G

    2010-01-01

    Concerns about the biological effects of space radiation are increasing rapidly due to the perspective of long-duration manned missions, both in relation to the International Space Station (ISS) and to manned interplanetary missions to Moon and Mars in the future. As a preparation for these long duration space missions it is important to ensure an excellent capability to evaluate the impact of space radiation on human health in order to secure the safety of the astronauts/cosmonauts and minimize their risks. It is therefore necessary to measure the radiation load on the personnel both inside and outside the space vehicles and certify that organ and tissue equivalent doses can be simulated as accurate as possible. In this paper we will present simulations using the three-dimensional Monte Carlo Particle and Heavy Ion Transport code System (PHITS) of long term dose measurements performed with the ESA supported experiment MATROSHKA (MTR), which is an anthropomorphic phantom containing over 6000 radiation detecto...

  1. Human and Artificial Agents in a Crash-Prone Financial Market

    E-Print Network [OSTI]

    Feldman, Todd; Friedman, Daniel

    2010-01-01

    based models and human subject experiments. Handbook ofout that labo- ratory experiments with human subjects oftenas a laboratory experiment with human subjects, and Sect. 4

  2. Stromal Modulation of Radiation Carcinogenesis in Breast Cancer

    E-Print Network [OSTI]

    Nguyen, David Hiendat Hua

    2011-01-01

    radiation research related to human health is to predict the biological impact of exposure to low dose (

  3. Five-year Results of Whole Breast Intensity Modulated Radiation Therapy for the Treatment of Early Stage Breast Cancer: The Fox Chase Cancer Center Experience

    SciTech Connect (OSTI)

    Keller, Lanea M.M.; Sopka, Dennis M.; Li Tianyu; Klayton, Tracy; Li Jinsheng; Anderson, Penny R.; Bleicher, Richard J.; Sigurdson, Elin R.; Freedman, Gary M.

    2012-11-15

    Purpose: To report the 5-year outcomes using whole-breast intensity-modulated radiation therapy (IMRT) for the treatment of early-stage-breast cancer at the Fox Chase Cancer Center. Methods and Materials: A total of 946 women with early-stage breast cancer (stage 0, I, or II) were treated with IMRT after surgery with or without systemic therapy from 2003-2010. Whole-breast radiation was delivered via an IMRT technique with a median whole-breast radiation dose of 46 Gy and median tumor bed boost of 14 Gy. Endpoints included local-regional recurrence, cosmesis, and late complications. Results: With a median follow-up of 31 months (range, 1-97 months), there were 12 ipsilateral breast tumor recurrences (IBTR) and one locoregional recurrence. The 5-year actuarial IBTR and locoregional recurrence rates were 2.0% and 2.4%. Physician-reported cosmestic outcomes were available for 645 patients: 63% were considered 'excellent', 33% 'good', and <1.5% 'fair/poor'. For physician-reported cosmesis, boost doses {>=}16 Gy, breast size >900 cc, or boost volumes >34 cc were significantly associated with a 'fair/poor' cosmetic outcome. Fibrosis, edema, erythema, and telangectasia were also associated with 'fair/poor' physician-reported cosmesis; erythema and telangectasia remained significant on multivariate analysis. Patient-reported cosmesis was available for 548 patients, and 33%, 50%, and 17% of patients reported 'excellent', 'good', and 'fair/poor' cosmesis, respectively. The use of a boost and increased boost volume: breast volume ratio were significantly associated with 'fair/poor' outcomes. No parameter for patient-reported cosmesis was significant on multivariate analysis. The chances of experiencing a treatment related effect was significantly associated with a boost dose {>=}16 Gy, receipt of chemotherapy and endocrine therapy, large breast size, and electron boost energy. Conclusions: Whole-breast IMRT is associated with very low rates of local recurrence at 5 years, 83%-98% 'good/excellent' cosmetic outcomes, and minimal chronic toxicity, including late fibrosis.

  4. and machines, on-board autonomy, human control, and ground automation.

    E-Print Network [OSTI]

    Stone, Peter

    and machines, on-board autonomy, human control, and ground automation. CHASER is comprised of three activity and radiation flux as well as an association of Lyman-alpha fluxes with individual active regions at the sun. This data is used for testing various portions of the DATA experiment with nonsolar pointing data

  5. Experiments: Preparation and Measurement

    E-Print Network [OSTI]

    Neumaier, Arnold

    the experimental set­up und the results of performing the experiment. Again, this is part of human cultureExperiments: Preparation and Measurement by Arnold Neumaier, Vienna March 1996 Abstract Introduction Experiments, properly arranged, provide information about a physical system by suitable

  6. The Impact of Abrupt Suspension of Solar Radiation Management (Termination Effect) in Experiment G2 of the Geoengineering Model Intercomparison Project (GeoMIP)

    SciTech Connect (OSTI)

    Jones, Andrew; Haywood, J.; Alterskjaer, Kari; Boucher, Olivier; Cole, Jason N.; Curry, Charles L.; Irvine, Peter; Ji, Duoying; Kravitz, Benjamin S.; Kristjansson, Jon E.; Moore, John; Niemeier, Ulrike; Robock, Alan; Schmidt, Hauke; Singh, Balwinder; Tilmes, S.; Watanabe, Shingo; Yoon, Jin-Ho

    2013-09-11

    We have examined changes in climate which result from the sudden termination of geoengineering after 50 years of offsetting a 1% per annum increase in CO2 concentra- tions as simulated by 11 different climate models in experiment G2 of the Geoengineering Model Intercomparison Project. The models agree on a rapid rate of global-mean warming following termination, accompanied by increases in global-mean precipitation rate and in plant net primary productivity, and decreases in sea-ice cover. While there is a considerable degree of consensus for the geographical distribution of warming, there is much less of an agreement regarding the patterns of change in the other quantities.

  7. Interleukin-1?-induced barrier dysfunction is signaled through PKC-? in human brain microvascular endothelium

    E-Print Network [OSTI]

    Rigor, Robert R Ph.D.

    2012-01-01

    ZO-1 (9). In parallel experiments with human umbilical veinHUMAN BBB DYSFUNCTION more, immunoprecipitation experiments

  8. Symptomatic Outcomes in Relation to Tumor Expansion After Fractionated Stereotactic Radiation Therapy for Vestibular Schwannomas: Single-Institutional Long-Term Experience

    SciTech Connect (OSTI)

    Aoyama, Hidefumi; Department of Radiology, Division of Radiation Oncology, Niigata University Graduate School of Medical and Dental Sciences, Niigata ; Onodera, Shunsuke; Takeichi, Norihito; Onimaru, Rikiya; Terasaka, Shunsuke; Sawamura, Yutaka; Shirato, Hiroki

    2013-02-01

    Purpose: The effect of transient tumor expansion after conventionally fractionated stereotactic radiation therapy (SRT) on the symptomatic outcomes is not well-known. Methods and Materials: This study enrolled 201 consecutive patients who received SRT for vestibular schwannoma. A conventional fractionation schedule was applied in 194 patients (97%), and 142 (71%) received a total dose of 50 Gy. The median follow-up time was 72 months. Results: The maximum diameter was 9 mm or less in 13 patients, 10-19 mm in 79 patients, 20-29 mm in 87 patients, and 30 mm or greater in 22 patients. At presentation, tumor size of 20 mm or greater was significantly associated with loss of serviceable hearing and trigeminal neuropathy. After SRT, tumor expansion was observed in 42 patients (21%). By tumor size, tumor expansion was observed in 0%, 11.4%, 25.6%, and 50% of patients with tumors of 9 mm or less, 10-19 mm, 20-29 mm, and 30 mm or greater, respectively, in diameter. The tumor expansion was significantly associated with an increased risk of hydrocephalus requiring shunt placement (P=.004), loss of serviceable hearing (P=.0064), and worsening of facial (P<.0001) and trigeminal nerve (P<.0001) functions. Spontaneous tumor shrinkage was observed in 29 of those 42 patients, mostly within 2 years after the expansion, and the majority of the worsened symptoms except for hearing resolved once the tumor had shrunk. As a result, salvage surgical resection for symptomatic relief was required in only 5% of patients. Conclusions: Fractionated SRT could be safely applied even for medium- to large-sized ({>=}20 mm) tumors. However, greater knowledge of the risks and consequences, including transient symptomatic worsening, and the time span of expansion will be required for the follow-up of patients after SRT to avoid unnecessary surgical intervention.

  9. Danger radiations

    ScienceCinema (OSTI)

    None

    2011-04-25

    Le conférencier Mons.Hofert parle des dangers et risques des radiations, le contrôle des zones et les précautions ŕ prendre ( p.ex. film badge), comment mesurer les radiations etc.

  10. UV-radiation Induced Disruption of Dry-Cavities in Human ?D-crystallin Results in Decreased Stability and Faster Unfolding

    E-Print Network [OSTI]

    Xia, Zhen

    Age-onset cataracts are believed to be expedited by the accumulation of UV-damaged human ?D-crystallins in the eye lens. Here we show with molecular dynamics simulations that the stability of ?D-crystallin is greatly reduced ...

  11. Risk of Low Dose/Low Dose Rate Ionizing Radiation to Humans Symposium at the EMS 2009 Annual Meeting - September 2006

    SciTech Connect (OSTI)

    Morgan, William F.; von Borstel, Robert C.; Brenner, David; Redpath, J. Leslie; Erickson, Barbra E.; Brooks, Antone L.

    2009-11-12

    The low dose symposium thoughtfully addressed controversy of risk from low dose radiation exposure, hormesis and radon therapy. The stem cell symposium cogently considered the role of DNA damage and repair in hematopoietic stem cells underlying aging and malignancy and provocatively presented evidence that stem cells may have distinct morphologies and replicative properties, as well as special roles in cancer initiation. In the epigenetics symposium, studies illustrated the long range interaction of epigenetic mechanisms, the roles of CTCF and BORIS in region/specific regulation of epigenetic processes, the impact of DNA damage on epigenetic processes as well as links between epigenetic mechanisms and early nutrition and bystander effects.

  12. THE UNIVERSITY OF WESTERN ONTARIO Human Resources

    E-Print Network [OSTI]

    Cunningham, Ian

    Radiation Safety Coordinator on matters of all radiation safety including nuclear substances and radiationTHE UNIVERSITY OF WESTERN ONTARIO Human Resources Occupational Health and Safety SAFETY MANUAL FOR NON-MEDICAL X-RAY EQUIPMENT Prepared by Mr. H. Ly Radiation Safety Coordinator Approved

  13. Ultraviolet-light-induced transformation of human primary cells

    SciTech Connect (OSTI)

    Sutherland, B.M.

    1981-01-01

    The development of model systems for probing the ultraviolet radiation induced oncogenic transformation of human skin cells is described. (ACR)

  14. RADIATION MONITORING

    E-Print Network [OSTI]

    Thomas, R.H.

    2010-01-01

    Radiation Exposure due to a Boiling Water Reactor Plume fromIN THE VICINITY OF A BOILING WATER REACTOR EXPOSURE RATE

  15. Dispatcher Reliability Analysis : SPICA-RAIL Experiments

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    consider that humans are fully reliable. But experience shows that many accidents involve human failuresDispatcher Reliability Analysis : SPICA-RAIL Experiments Fabien Belmonte, Jean-Louis Boulanger of scenarios and evaluate the behaviour of human operators. A state of the art in human reliability is pre

  16. The GLUEX Experiment

    SciTech Connect (OSTI)

    M.R. Shepherd

    2009-12-01

    The GLUEX experiment, to be constructed in the new Hall D at Jefferson Lab as part of the 12 GeV upgrade, will utilize a linearly polarized 9 GeV photon beam, produced via coherent bremsstrahlung radiation off of a diamond wafer, incident on a proton target to conduct a search for exotic hybrid mesons. A summary of the physics motivation for the experiment and the key factors that drive the design of the detector and beam line is presented.

  17. The Ghost of the Bomb : the Bravo Medical Program, scientific uncertainty, and the legacy of U.S. Cold War science, 1954-2005

    E-Print Network [OSTI]

    Harkewicz, Laura J.

    2010-01-01

    L. Martenson. “Human Radiation Experiments and the FormationCommittee on Human Radiation Experiments (ACHRE). Finaltherapy without human radiation experiments? ” Granted the

  18. RADON PROGENY AS AN EXPERIMENTAL TOOL FOR DOSIMETRY OF NANOAEROSOLS

    E-Print Network [OSTI]

    Ruzer, Lev S.

    2008-01-01

    such human experiments need radiation and environmentalthat radiation exposure in the human experiment was lessproposed radiation dose during a human experiment will be

  19. Radiation detector

    DOE Patents [OSTI]

    Fultz, B.T.

    1980-12-05

    Apparatus is provided for detecting radiation such as gamma rays and x-rays generated in backscatter Moessbauer effect spectroscopy and x-ray spectrometry, which has a large window for detecting radiation emanating over a wide solid angle from a specimen and which generates substantially the same output pulse height for monoenergetic radiation that passes through any portion of the detection chamber. The apparatus includes a substantially toroidal chamber with conductive walls forming a cathode, and a wire anode extending in a circle within the chamber with the anode lying closer to the inner side of the toroid which has the least diameter than to the outer side. The placement of the anode produces an electric field, in a region close to the anode, which has substantially the same gradient in all directions extending radially from the anode, so that the number of avalanche electrons generated by ionizing radiation is independent of the path of the radiation through the chamber.

  20. Induction of stable p53 oncoprotein and of c-myc overexpression in cultured normal human uroepithelium by radiation and N-nitrosodiethanolamine

    SciTech Connect (OSTI)

    Mothersill, C.; Seymour, C.B. ); Harney, J. )

    1994-04-01

    Uroepithelium cultured from normal patients without cancer (60 individuals) was found to segregate into four subtypes based on the level of carcinogen treatment needed to induce abnormal p53 and c-myc. Twenty-two percent of patient cultures never showed abnormal p53 expression, even after chronic exposure to nitrosamines, while a further 26% required only a single dose of radiation to induce the abnormal protein. The remaining patients had tissues which, while initially negative for stable p53, became positive when put into culture and stimulated to grow. The c-myc protein was overexpressed in all cultures with abnormal p53. It would appear that elevated expression of conformationally inactive p53 and of high levels of c-myc represents an early response of normal uroepithelial cells to carcinogen challenge. It also appears that a relatively high number of patients without cancer express these proteins when their cells are challenged to grow; a pre-exposure to environmental carcinogens such as nitrosamines in cigarette smoke is likely to be involved. 30 refs., 3 figs., 3 tabs.

  1. Directed mammalian gene regulatory networks using expression and comparative genomic hybridization microarray data from radiation hybrids

    E-Print Network [OSTI]

    2009-01-01

    generation whole genome-radiation hybrid map spanning theA high- resolution radiation hybrid map of the human genomeRecently we have used radiation hybrids to map loci based on

  2. On the Difficulty of Replicating Human Subjects Studies in Software Engineering

    E-Print Network [OSTI]

    Easterbrook, Steve

    a literal replication of a human subjects experiment that examined the relationship between a simple test: MISCELLANEOUS General Terms: Experimentation Keywords experience report, empirical, human subjects, replication with replication for experiments involving human subjects. Such experi- ments are increasingly important

  3. Human and Ecological Risk Assessment: Vol. 2, No.4, pp. 920-938, 1996 Alexander Shlyakhter, Leonid Mirny, Alexander Vlasov,* and Richard Wilson..

    E-Print Network [OSTI]

    Shlyakhter, Ilya

    -'~"..~-,., - ~~ ~ I Human and Ecological Risk Assessment: Vol. 2, No.4, pp. 920-938, 1996 of the authors (RW) was an electronic device to produce random numbers for use in statistical experiments random numbers were selectedby a roulette wheel. Now, 45 .Visitor from Institute of Radiation Hygiene

  4. Radiation dosimeter

    DOE Patents [OSTI]

    Fox, R.J.

    1981-09-01

    A radiation detector readout circuit is provided which produces a radiation dose-rate readout from a detector even through the detector output may be highly energy dependent. A linear charge amplifier including an output charge pump circuit amplifies the charge signal pulses from the detector and pumps the charge into a charge storage capacitor. The discharge rate of the capacitor through a resistor is controlled to provide a time-dependent voltage which when integrated provides an output proportional to the dose-rate of radiation detected by the detector. This output may be converted to digital form for readout on a digital display.

  5. Radiation dosimeter

    DOE Patents [OSTI]

    Fox, Richard J. (Oak Ridge, TN)

    1983-01-01

    A radiation detector readout circuit is provided which produces a radiation dose-rate readout from a detector even though the detector output may be highly energy dependent. A linear charge amplifier including an output charge pump circuit amplifies the charge signal pulses from the detector and pumps the charge into a charge storage capacitor. The discharge rate of the capacitor through a resistor is controlled to provide a time-dependent voltage which when integrated provides an output proportional to the dose-rate of radiation detected by the detector. This output may be converted to digital form for readout on a digital display.

  6. Radiation receiver

    DOE Patents [OSTI]

    Hunt, A.J.

    1983-09-13

    The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles. 5 figs.

  7. Radiation receiver

    DOE Patents [OSTI]

    Hunt, Arlon J. (Oakland, CA)

    1983-01-01

    The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles.

  8. Radiation Protection Act (Pennsylvania)

    Broader source: Energy.gov [DOE]

    This Act combines the radiation safety provisions of The Atomic Energy Development and Radiation Control Act and the Environmental Radiation Protection Act, and empowers the Department of...

  9. DETECTORS FOR RADIATION DOSIMETRY

    E-Print Network [OSTI]

    Perez-Mendez, V.

    2010-01-01

    I. Applications of Radiation Detectors 1) X-Rays, Gammaof the Conference DETECTORS FOR RADIATION DOSIMETRY VictorT E D LBL9651 DETECTORS FOR RADIATION DOSIMETRY - DISCLAIM*

  10. STRUCTURAL AND MECHANICAL EFFECTS OF RADIATION EXPOSURE ON FILLED...

    Office of Scientific and Technical Information (OSTI)

    STRUCTURAL AND MECHANICAL EFFECTS OF RADIATION EXPOSURE ON FILLED ELASTOMERS - RECENT INSIGHTS FROM EXPERIMENTS AND MODELING Citation Details In-Document Search Title: STRUCTURAL...

  11. NNSA participates in cloud-based radiation data collection drill...

    National Nuclear Security Administration (NNSA)

    radiation data. The Network is built on the experiences and lessons learned from the Fukushima Daiichi reactor emergency that revealed the need for a coordinated effort across all...

  12. Decomposition of radiational effects of model feedbacks

    SciTech Connect (OSTI)

    Ellsaesser, H.W.; MacCracken, M.C.; Potter, G.L.; Mitchell, C.S.

    1981-08-01

    Three separate doubled CO/sub 2/ experiments with the statistical dynamic model are used to illustrate efforts to study the climate dynamics, feedbacks, and interrelationships of meteorological parameters by decomposing and isolating their individual effects on radiation transport.

  13. HUMAN RADIATION STUDIES: REMEMBERING THE EARLY YEARS

    Office of Scientific and Technical Information (OSTI)

    what we were dealing with at Los Alamos. Plutonium and tritium and fission products were new types of materials for me. At least during the first year, one of the things that I...

  14. HUMAN RADIATION STUDIES: REMEMBERING THE EARLY YEARS

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield MunicipalTechnical Report:Speeding accessby aLED Street LightingFrom the BuildingHASL-25837489-FPDOBEH

  15. Transition Radiation Spectra of Electrons from 1 to 10 GeV/c in Regular and Irregular Radiators

    E-Print Network [OSTI]

    Andronic, A; Bailhache, R; Baumann, C; Braun-Munzinger, P; Bucher, D; Busch, O; Catanescu, V; Chernenko, S P; Christakoglou, P; Fateev, O V; Freuen, S; Garabatos, C; Gottschlag, H; Gunji, T; Hamagaki, H; Herrmann, N; Hoppe, M; Lindenstruth, V; Lippmann, C; Morino, Y; Panebratsev, Yu A; Petridis, A; Petrovici, M; Rusanov, I R; Saitô, S; Sandoval, A; Schicker, R; Soltveit, H K; Stachel, J; Stelzer, H; Vassiliou, Maria; Vulpescu, B; Wessels, J P; Wilk, A; Yurevich, V; Zanevsky, Yu

    2006-01-01

    We present measurements of the spectral distribution of transition radiation generated by electrons of momentum 1 to 10 GeV/c in different radiator types. We investigate periodic foil radiators and irregular foam and fiber materials. The transition radiation photons are detected by prototypes of the drift chambers to be used in the Transition Radiation Detector (TRD) of the ALICE experiment at CERN, which are filled with a Xe, CO2 (15 %) mixture. The measurements are compared to simulations in order to enhance the quantitative understanding of transition radiation production, in particular the momentum dependence of the transition radiation yield.

  16. Thermostatic Radiator Valve Evaluation

    SciTech Connect (OSTI)

    Dentz, J.; Ansanelli, E.

    2015-01-01

    A large stock of multifamily buildings in the Northeast and Midwest are heated by steam distribution systems. Losses from these systems are typically high and a significant number of apartments are overheated much of the time. Thermostatically controlled radiator valves (TRVs) are one potential strategy to combat this problem, but have not been widely accepted by the residential retrofit market. In this project, the ARIES team sought to better understand the current usage of TRVs by key market players in steam and hot water heating and to conduct limited experiments on the effectiveness of new and old TRVs as a means of controlling space temperatures and reducing heating fuel consumption. The project included a survey of industry professionals, a field experiment comparing old and new TRVs, and cost-benefit modeling analysis using BEopt™ (Building Energy Optimization software).

  17. Human-Driven Spatial Language for Human-Robot Interaction Marjorie Skubic and Zhiyu Huo

    E-Print Network [OSTI]

    He, Zhihai "Henry"

    to comprehend spatial descriptions. As a first step, a series of human subject experiments is being conducted adults. Based on the results of these human subject experiments, algorithms will be developed for robot will ultimately be tested in future human subject experiments using both virtual and physical robots. Thus

  18. Mammalian Tissue Response to Low Dose Ionizing Radiation: The Role of Oxidative Metabolism and Intercellular Communication

    SciTech Connect (OSTI)

    Azzam, Edouard I

    2013-01-16

    The objective of the project was to elucidate the mechanisms underlying the biological effects of low dose/low dose rate ionizing radiation in organs/tissues of irradiated mice that differ in their susceptibility to ionizing radiation, and in human cells grown under conditions that mimic the natural in vivo environment. The focus was on the effects of sparsely ionizing cesium-137 gamma rays and the role of oxidative metabolism and intercellular communication in these effects. Four Specific Aims were proposed. The integrated outcome of the experiments performed to investigate these aims has been significant towards developing a scientific basis to more accurately estimate human health risks from exposures to low doses ionizing radiation. By understanding the biochemical and molecular changes induced by low dose radiation, several novel markers associated with mitochondrial functions were identified, which has opened new avenues to investigate metabolic processes that may be affected by such exposure. In particular, a sensitive biomarker that is differentially modulated by low and high dose gamma rays was discovered.

  19. Radiation Safety

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMassR&D100 Winners * Impacts on GlobalRachel Ruggirello RachelRadiation DrySafety Home

  20. Digestion Experiments

    E-Print Network [OSTI]

    Fraps, G. S. (George Stronach)

    1908-01-01

    STATION. ppp DIGESTION EXPERIMENTS G. S. FRAPS, PH. D., CHEMIST. POSTOFFICE COLLEGE SL'ATION, HRAZOS COUNTY, TEXAS. AUSTIN, TEXAS: \\'ON BOECKMANN-JONES CO., PRLNTEHP. 1908 TEXAS AGRICULTURAL EXPERIMENT 8TArFIONS. OFFICERS. GOVERNING BOARD... OF CONTENTS . 1 . Digestibility of 1Caffir Corn. Milo Maize. and Molasses ....... G .................................... Ilcfinition of Terms 7 .................................. Method of Experiment 7 ............ Digestibility of Basal Ration of Meal...

  1. RADIATION RESEARCH 162, 600601 (2004) 0033-7587/04 $15.00

    E-Print Network [OSTI]

    2004-01-01

    600 RADIATION RESEARCH 162, 600­601 (2004) 0033-7587/04 $15.00 2004 by Radiation Research Society in the Human Genome'' by Johannes et al. (Radiat. Res. 161, 540­548, 2004) David J. Brenner Center there may be two reasons for this discrepancy: 1. For their comparison with low-LET radiation, Johannes et

  2. The PAMELA experiment The PAMELA Collaboration

    E-Print Network [OSTI]

    Morselli, Aldo

    experiment (RIM­0.1, called Si­eye­1, Bidoli, et al., 1997) has taken data on board of the Russian MIR on a Transition Radiation Detector (TRD). It is made by carbon fiber radiators and straw tube detectors and its interacting in the mechanical structure of the telescope (ANTI). The total height of PAMELA is 105 cm

  3. Genome Wide Evaluation of Normal Human Tissue in Response to...

    Office of Scientific and Technical Information (OSTI)

    Wide Evaluation of Normal Human Tissue in Response to Controlled, In vivo Low-Dose Low LET Ionizing Radiation Exposure: Pathways and Mechanisms Final Report, September 2013 Rocke,...

  4. Adaptors for radiation detectors

    DOE Patents [OSTI]

    Livesay, Ronald Jason

    2014-04-22

    Described herein are adaptors and other devices for radiation detectors that can be used to make accurate spectral measurements of both small and large bulk sources of radioactivity, such as building structures, soils, vessels, large equipment, and liquid bodies. Some exemplary devices comprise an adaptor for a radiation detector, wherein the adaptor can be configured to collimate radiation passing through the adapter from an external radiation source to the radiation detector and the adaptor can be configured to enclose a radiation source within the adapter to allow the radiation detector to measure radiation emitted from the enclosed radiation source.

  5. Adaptors for radiation detectors

    DOE Patents [OSTI]

    Livesay, Ronald Jason

    2015-07-28

    Described herein are adaptors and other devices for radiation detectors that can be used to make accurate spectral measurements of both small and large bulk sources of radioactivity, such as building structures, soils, vessels, large equipment, and liquid bodies. Some exemplary devices comprise an adaptor for a radiation detector, wherein the adaptor can be configured to collimate radiation passing through the adapter from an external radiation source to the radiation detector and the adaptor can be configured to enclose a radiation source within the adapter to allow the radiation detector to measure radiation emitted from the enclosed radiation source.

  6. Radiation dosimeters

    DOE Patents [OSTI]

    Hoelsher, James W. (Pullman, WA); Hegland, Joel E. (Pullman, WA); Braunlich, Peter F. (Pullman, WA); Tetzlaff, Wolfgang (Pullman, WA)

    1992-01-01

    Radiation dosimeters and dosimeter badges. The dosimeter badges include first and second parts which are connected to join using a securement to produce a sealed area in which at least one dosimeter is held and protected. The badge parts are separated to expose the dosimeters to a stimulating laser beam used to read dose exposure information therefrom. The badge is constructed to allow automated disassembly and reassembly in a uniquely fitting relationship. An electronic memory is included to provide calibration and identification information used during reading of the dosimeter. Dosimeter mounts which reduce thermal heating requirements are shown. Dosimeter constructions and production methods using thin substrates and phosphor binder-layers applied thereto are also taught.

  7. Division of Human Resources Assessing Education and

    E-Print Network [OSTI]

    Meyers, Steven D.

    Division of Human Resources Assessing Education and Past Work Experience Questions (813) 974 of Human Resources Assessing Education and Past Work Experience Questions (813) 974-2970 Recruitment the applicant's education for United States educational equivalency. Human Resources will use the review

  8. Investigating Radiation Shielding Properties of Different Mineral Origin Heavyweight Concretes

    SciTech Connect (OSTI)

    Basyigit, Celalettin; Uysal, Volkan; Kilincarslan, Semsettin; Akkas, Ayse; Mavi, Betuel; Guenoglu, Kadir; Akkurt, Iskender

    2011-12-26

    The radiation although has hazardous effects for human health, developing technologies bring lots of usage fields to radiation like in medicine and nuclear power station buildings. In this case protecting from undesirable radiation is a necessity for human health. Heavyweight concrete is one of the most important materials used in where radiation should be shielded, like those areas. In this study, used heavyweight aggregates of different mineral origin (Limonite, Siderite), in order to prepare different series in concrete mixtures and investigated radiation shielding properties. The experimental results on measuring the radiation shielding, the heavyweight concrete prepared with heavyweight aggregates of different mineral origin show that, are useful radiation absorbents when they used in concrete mixtures.

  9. DEVELOPING VISUALIZATION TOOLS FOR THE DESIGN OF AIR TRAFFIC CONTROL EXPERIMENTS

    E-Print Network [OSTI]

    Cummings, Mary "Missy"

    for those human factors researchers and practitioners designing experiments. Designing an experimentDEVELOPING VISUALIZATION TOOLS FOR THE DESIGN OF AIR TRAFFIC CONTROL EXPERIMENTS ABSTRACT While, little attention has been paid to developing visualization tools for human factors researchers designing

  10. Intelligent Escort Robot Moving together with Human Methods for Human Position Recognition

    E-Print Network [OSTI]

    Ohya, Akihisa

    : Light-emitting device used in the experiments. robot is able to know the distance to the human thanksIntelligent Escort Robot Moving together with Human ­ Methods for Human Position Recognition in everyday life by interacting with humans. In order to escort a human, the robot needs to know the position

  11. Soliton molecules: Experiments and optimization

    SciTech Connect (OSTI)

    Mitschke, Fedor

    2014-10-06

    Stable compound states of several fiber-optic solitons have recently been demonstrated. In the first experiment their shape was approximated, for want of a better description, by a sum of Gaussians. Here we discuss an optimization strategy which helps to find preferable shapes so that the generation of radiative background is reduced.

  12. Experiment Profile:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    their shapes, how galaxies cluster and the brightness of exploding stars called supernovae. WHY IS THIS EXPERIMENT NEEDED NOW? Research during the last decade using different...

  13. DETECTORS FOR RADIATION DOSIMETRY

    E-Print Network [OSTI]

    Perez-Mendez, V.

    2010-01-01

    J. Price, "Nuclear Radiation Detection" (2nd ed. , New York:4) G. F. Knoll, "Radiation Detection and Measurement" (NewSons, Inc. from "Radiation Detection and Measurement," G. F.

  14. Dosimetry experiments at the MEDUSA Facility (Little Mountain).

    SciTech Connect (OSTI)

    Harper-Slaboszewicz, Victor Jozef; Shaneyfelt, Marty Ray; Sheridan, Timothy J.; Hartman, E. Frederick; Schwank, James Ralph

    2010-10-01

    A series of experiments on the MEDUSA linear accelerator radiation test facility were performed to evaluate the difference in dose measured using different methods. Significant differences in dosimeter-measured radiation dose were observed for the different dosimeter types for the same radiation environments, and the results are compared and discussed in this report.

  15. Transformative Experiences

    E-Print Network [OSTI]

    Gering, Jon C.

    Transformative Experiences Internships & Field Schools Honors & Research Faculty Notables Alumni have at least one poten- tially transformative experi- ence - an opportunity to de- sign and carry out to be transformational are study abroad, internships, service learning, research, student-led learning, and lead- ership

  16. Radiation Control (Virginia)

    Broader source: Energy.gov [DOE]

    The Department of Health is responsible for regulating radiation and radioactive materials in the Commonwealth of Virginia. Although the Department's Radiation Control Program primarily focuses on...

  17. RADIATIVE AND PASSIVE COOLING

    E-Print Network [OSTI]

    Martin, M.

    2011-01-01

    Ext. 6782 Radiative and Passive Cooling Marlo Martin andof the Second Nation- al Passive Solar Conference (owned rights. ,I I RADIATIVE AND PASSIVE COOLING* LAIVRENCE

  18. RADIATION HARD PHOTODETECTORS BASED ON FINE-MESH PHOTOTUBES FOR CALORIMETRY IN VERY FORWARD RAPIDITY REGION

    E-Print Network [OSTI]

    Titov, Anatoly

    in the experiment CASTOR at LHC for the detection of Cherenkov radiation must provide stable operation for higher308 RADIATION HARD PHOTODETECTORS BASED ON FINE-MESH PHOTOTUBES FOR CALORIMETRY IN VERY FORWARD), the radiation fields are very high. Ionizing radiation levels reach hundreds of kGy and neutron fluences go up

  19. Radiation Protection and Licensing FNAL Radiation Physics Team

    E-Print Network [OSTI]

    McDonald, Kirk

    (ALARA). January 13, 2012 Radiation Protection and Licensing #12;4 Shielding for Prompt Radiation Protect

  20. Human Dimensions of Wildlife Research Norman Dandy

    E-Print Network [OSTI]

    Human Dimensions of Wildlife Research Norman Dandy Social & Economic Research Group #12;Wildlife) · Human-dimensions of species management (HDSM) Research Projects #12;Collaborative Frameworks for Land of woodland landscapes ­ discussion groups, · Choice experiments, · Fellowships / Placements, · Newsletters

  1. Radiation shielding properties of barite coated fabric by computer programme

    SciTech Connect (OSTI)

    Akarslan, F.; Molla, T.; Üncü, I. S.; K?l?ncarslan, S.; Akkurt, I.

    2015-03-30

    With the development of technology radiation started to be used in variety of different fields. As the radiation is hazardous for human health, it is important to keep radiation dose as low as possible. This is done mainly using shielding materials. Barite is one of the important materials in this purpose. As the barite is not used directly it can be used in some other materials such as fabric. For this purposes barite has been coated on fabric in order to improve radiation shielding properties of fabric. Determination of radiation shielding properties of coated fabric has been done by using computer program written C# language. With this program the images obtained from digital Rontgen films is used to determine radiation shielding properties in terms of image processing numerical values. Those values define radiation shielding and in this way the coated barite effect on radiation shielding properties of fabric has been obtained.

  2. Denoising solar radiation data using coiflet wavelets

    SciTech Connect (OSTI)

    Karim, Samsul Ariffin Abdul Janier, Josefina B. Muthuvalu, Mohana Sundaram; Hasan, Mohammad Khatim; Sulaiman, Jumat; Ismail, Mohd Tahir

    2014-10-24

    Signal denoising and smoothing plays an important role in processing the given signal either from experiment or data collection through observations. Data collection usually was mixed between true data and some error or noise. This noise might be coming from the apparatus to measure or collect the data or human error in handling the data. Normally before the data is use for further processing purposes, the unwanted noise need to be filtered out. One of the efficient methods that can be used to filter the data is wavelet transform. Due to the fact that the received solar radiation data fluctuates according to time, there exist few unwanted oscillation namely noise and it must be filtered out before the data is used for developing mathematical model. In order to apply denoising using wavelet transform (WT), the thresholding values need to be calculated. In this paper the new thresholding approach is proposed. The coiflet2 wavelet with variation diminishing 4 is utilized for our purpose. From numerical results it can be seen clearly that, the new thresholding approach give better results as compare with existing approach namely global thresholding value.

  3. Predicting the radiation tolerance of oxides

    SciTech Connect (OSTI)

    Sickafus, K. (Kurt E.); Grimes, R. W. (Robin W.)

    2001-01-01

    We have used atomistic computer simulations and ion beam irradiations to examine radiation damage accumulation in multicomponent oxides, We have developed contour energy maps via computer simulations to predict the effects of oxide structure and chemical composition on radiation-induced atomic disorder, defect migration, and swelling. Ion irradiation damage experiments have been perfonned on, pyrochlore and fluorite-structured oxide ceramics to test the predictions from computer models.

  4. Phase contrast portal imaging using synchrotron radiation

    SciTech Connect (OSTI)

    Umetani, K.; Kondoh, T.

    2014-07-15

    Microbeam radiation therapy is an experimental form of radiation treatment with great potential to improve the treatment of many types of cancer. We applied a synchrotron radiation phase contrast technique to portal imaging to improve targeting accuracy for microbeam radiation therapy in experiments using small animals. An X-ray imaging detector was installed 6.0 m downstream from an object to produce a high-contrast edge enhancement effect in propagation-based phase contrast imaging. Images of a mouse head sample were obtained using therapeutic white synchrotron radiation with a mean beam energy of 130 keV. Compared to conventional portal images, remarkably clear images of bones surrounding the cerebrum were acquired in an air environment for positioning brain lesions with respect to the skull structure without confusion with overlapping surface structures.

  5. DETECTORS FOR RADIATION DOSIMETRY

    E-Print Network [OSTI]

    Perez-Mendez, V.

    2010-01-01

    RPL) The interaction of radiation with matter in crystallineradiation. Some interactions with crystalline matter are

  6. Radiation stability of graphene under extreme conditions

    SciTech Connect (OSTI)

    Kumar, Sunil, E-mail: kumar.sunil092@gmail.com; Tripathi, Ambuj; Khan, Saif A.; Pannu, Compesh; Avasthi, Devesh K. [Materials Science Group, Inter University Accelerator Centre, Aruna Asaf Ali Marg, New Delhi 110067 (India)

    2014-09-29

    In this letter, we report radiation stability of graphene under extreme condition of high energy density generated by 150?MeV Au ion irradiation. The experiment reveals that graphene is radiation resistant for irradiation at 10{sup 14?}ions/cm{sup 2} of 150?MeV Au ions. It is significant to note that annealing effects are observed at lower fluences whereas defect production occurs at higher fluences but significant crystallinity is retained. Our results demonstrate applicability of graphene based devices in radiation environment and space applications.

  7. Radiative heat transfer between dielectric bodies

    E-Print Network [OSTI]

    Svend-Age Biehs

    2011-03-16

    The recent development of a scanning thermal microscope (SThM) has led to measurements of radiative heat transfer between a heated sensor and a cooled sample down to the nanometer range. This allows for comparision of the known theoretical description of radiative heat transfer, which is based on fluctuating electrodynamics, with experiment. The theory itself is a macroscopic theory, which can be expected to break down at distances much smaller than 10-8m. Against this background it seems to be reasonable to revisit the known macroscopic theory of fluctuating electrodynamics and of radiative heat transfer.

  8. Dynamics of a bouncing ball in human performance Dagmar Sternad

    E-Print Network [OSTI]

    Sternad, Dagmar

    of a dynamically stable period-one regime. In a series of experiments, human subjects bounced a ball rhythmically human movement and physical experi- mental systems is that while the variables and parameters of physical experiments are under the experimenter's control, human subjects when bouncing a ball have

  9. Bayesian optimization explains human active search Department of Computer Science

    E-Print Network [OSTI]

    Itti, Laurent

    , predicts human per- formance and searched locations better. In 6 follow-up controlled experiments over 76 literature, we design and conduct a series of experiments to understand human search and active learning;2 Experiments and Results We seek to study human search behavior directly on 1D function optimization

  10. Ferromagnetic Antenna and its Application to Generation and Detection of Gravitational Radiation

    E-Print Network [OSTI]

    Fran De Aquino

    2002-10-30

    A new type of antenna, which we have called Ferromagnetic Antenna, has been considered for Generation and Detection of Gravitational Radiation. A simple experiment, in which gravitational radiation at 10 GHz can be emitted and received in laboratory, is presented.

  11. Device for calibrating a radiation detector system

    DOE Patents [OSTI]

    Mc Fee, Matthew C. (New Ellenton, SC); Kirkham, Tim J. (Beech Island, SC); Johnson, Tippi H. (Aiken, SC)

    1994-01-01

    A device for testing a radiation detector system that includes at least two arrays of radiation detectors that are movable with respect to each other. The device includes a "shield plate" or shell, and an opposing "source plate" containing a source of ionizing radiation. Guides are attached to the outer surface of the shell for engaging the forward ends of the detectors, thereby reproducibly positioning the detectors with respect to the source and with respect to each other, thereby ensuring that a predetermined portion of the radiation emitted by the source passes through the shell and reaches the detectors. The shell is made of an hydrogenous material having approximately the same radiological attenuation characteristics as composite human tissue. The source represents a human organ such as the lungs, heart, kidneys, heart, liver, spleen, pancreas, thyroid, testes, prostate, or ovaries. The source includes a source of ionizing radiation having a long half-life and an activity that is within the range typically searched for in human subjects.

  12. Device for calibrating a radiation detector system

    DOE Patents [OSTI]

    McFee, M.C.; Kirkham, T.J.; Johnson, T.H.

    1994-12-27

    A device is disclosed for testing a radiation detector system that includes at least two arrays of radiation detectors that are movable with respect to each other. The device includes a ''shield plate'' or shell, and an opposing ''source plate'' containing a source of ionizing radiation. Guides are attached to the outer surface of the shell for engaging the forward ends of the detectors, thereby reproducibly positioning the detectors with respect to the source and with respect to each other, thereby ensuring that a predetermined portion of the radiation emitted by the source passes through the shell and reaches the detectors. The shell is made of an hydrogenous material having approximately the same radiological attenuation characteristics as composite human tissue. The source represents a human organ such as the lungs, heart, kidneys, liver, spleen, pancreas, thyroid, testes, prostate, or ovaries. The source includes a source of ionizing radiation having a long half-life and an activity that is within the range typically searched for in human subjects. 3 figures.

  13. Crawling Waves from Radiation Force Excitation ZAEGYOO HAH,1

    E-Print Network [OSTI]

    Parker, Kevin J.

    Crawling Waves from Radiation Force Excitation ZAEGYOO HAH,1 CHRISTOPHER HAZARD,2 YOUNG THUNG CHO1 from focused beams that produce radiation force excitation within the tissue. Some examples are also radiofrequency ablated hepatic lesions in vitro 6,7 to characterize human skeletal muscle in vivo 8, 9

  14. Radiation physics, biophysics, and radiation biology. Progress report, December 1, 1993--November 30, 1994

    SciTech Connect (OSTI)

    Hall, E.J.; Zaider, M.

    1994-05-01

    Research at the Center for Radiological Research is a blend of physics, chemistry and biology and epitomizes the multidisciplinary approach towards understanding the mechanisms involved in the health problems resulting from human exposure to ionizing radiations. To an increasing extent, the focus of attention is on biochemistry and the application of the techniques of molecular biology to the problems of radiation biology. Research highlights from the past year are briefly described.

  15. X-ray mammography with synchrotron radiation

    SciTech Connect (OSTI)

    Burattini, E. (CNR and INFN-Laboratori Nazionali di Frascati, Frascati, Rome (Italy)); Gambaccini, M.; Marziani, M.; Rimondi, O. (Dipartimento di Fisica dell'Universita and Sezione INFN di Ferrara, Ferrara (Italy)); Indovina, P.L. (Dipartimento di Scienze Fisiche dell'Universita and Sezione INFN di Napoli, Naples (Italy)); Pocek, M.; Simonetti, G. (Istituto di Radiologia, Ospedale Sant'Eugenio, Universita di Tor Vergata, Rome (Italy)); Benassi, M.; Tirelli, C. (Istituto Nazionale del Cancro, Regina Elena, Rome (Italy)); Passariello, R. (Cattedra di Radiologia, Universita dell'Aquila, L'Aquila (Italy))

    1992-01-01

    For the first time in the literature, radiographs of breast phantoms were obtained using several monochromatic synchrotron radiation x-ray beams of selected energy in the range from 14 to 26 keV. In addition, after optimization of the photon energy as a function of the phantom thickness, several mammographs were obtained on surgically removed human breast specimens containing cancer nodules. Comparison between radiographs using a conventional x-ray unit and those obtained of the same specimens utilizing synchrotron monochromatic beams clearly shows that higher contrast and better resolution can be achieved with synchrotron radiation. These results demonstrate the possibility of obtaining radiographs of excised human breast tissue containing a greater amount of radiological information using synchrotron radiation.

  16. The carboxyl-terminal of BRCA1 is required for subnuclear assembly of RAD51 after treatment with cisplatin but not ionizing radiation in human breast and ovarian cancer cells

    SciTech Connect (OSTI)

    Zhou Chenyi; Huang Peng; Liu Jinsong . E-mail: jliu@mdanderson.org

    2005-10-28

    BRCA1 plays an important role in maintaining genomic stability through its involvement in DNA repair. Although it is known that BRCA1 and RAD51 form distinct DNA repair subnuclear complexes, or foci, following environmental insults to the DNA, the role of BRCA1 in this process remains to be characterized. The purpose of the study was therefore to determine the role of BRCA1 in the formation of RAD51 foci following treatment with cisplatin and ionizing radiation. We found that although a functional BRCA1 is required for the subnuclear assembly of BRCA1 foci following treatment with either ionizing radiation or cisplatin, a functional BRCA1 is required for RAD51 foci to form following treatment with cisplatin but not with ionizing radiation. Similar results were obtained in SKOV-3 cells when the level of BRCA1 expression was knocked down by stable expression of a retrovirus-mediated small-interfering RNA against BRCA1. We also found that the carboxyl-terminal of BRCA1 contains uncharacterized phosphorylation sites that are responsive to cisplatin. The functional BRCA1 is also required for breast and ovarian cancer cells to mount resistance to cisplatin. These results suggest that the carboxyl-terminal of BRCA1 is required for the cisplatin-induced recruitment of RAD51 to the DNA-damage site, which may contribute to cisplatin resistance.

  17. DarkLight radiation backgrounds

    SciTech Connect (OSTI)

    Kalantarians, Narbe [University of Texas

    2013-11-01

    We report measurements of photon and neutron radiation levels observed while transmitting a 0.43 MW electron beam through millimeter-sized apertures and during beam-on, but accelerating gradient RF-on, operation. These measurements were conducted at the Free-Electron Laser (FEL) facility of the Jefferson National Accelerator Laboratory (JLab) using a 100 MeV electron beam from an energy-recovery linear accelerator. The beam was directed successively through 6 mm, 4 mm, and 2 mm diameter apertures of length 127 mm in aluminum at a maximum current of 4.3 mA (430 kW beam power). This study was conducted to characterize radiation levels for experiments that need to operate in this environment, such as the proposed DarkLight Experiment. We find that sustained transmission of a 430 kW CW beam through a 2 mm aperture is feasible with manageable beam-related backgrounds. We also find that during beam-off, RF-on operation, field emission inside the niobium cavities of the accelerator cryomodules is the primary source of ambient radiation.

  18. DarkLight radiation backgrounds

    SciTech Connect (OSTI)

    Kalantarians, N. [Department of Physics, Hampton University, Hampton VA 23668 (United States); Collaboration: DarkLight Collaboration

    2013-11-07

    We report measurements of photon and neutron radiation levels observed while transmitting a 0.43 MW electron beam through millimeter-sized apertures and during beam-on, but accelerating gradient RF-on, operation. These measurements were conducted at the Free-Electron Laser (FEL) facility of the Jefferson National Accelerator Laboratory (JLab) using a 100 MeV electron beam from an energy-recovery linear accelerator. The beam was directed successively through 6 mm, 4 mm, and 2 mm diameter apertures of length 127 mm in aluminum at a maximum current of 4.3 mA (430 kW beam power). This study was conducted to characterize radiation levels for experiments that need to operate in this environment, such as the proposed DarkLight Experiment. We find that sustained transmission of a 430 kW CW beam through a 2 mm aperture is feasible with manageable beam-related backgrounds. We also find that during beam-off, RF-on operation, field emission inside the niobium cavities of the accelerator cryomodules is the primary source of ambient radiation.

  19. Correlation between human observer performance and model observer performance in differential phase contrast CT

    SciTech Connect (OSTI)

    Li, Ke; Garrett, John; Chen, Guang-Hong

    2013-11-15

    Purpose: With the recently expanding interest and developments in x-ray differential phase contrast CT (DPC-CT), the evaluation of its task-specific detection performance and comparison with the corresponding absorption CT under a given radiation dose constraint become increasingly important. Mathematical model observers are often used to quantify the performance of imaging systems, but their correlations with actual human observers need to be confirmed for each new imaging method. This work is an investigation of the effects of stochastic DPC-CT noise on the correlation of detection performance between model and human observers with signal-known-exactly (SKE) detection tasks.Methods: The detectabilities of different objects (five disks with different diameters and two breast lesion masses) embedded in an experimental DPC-CT noise background were assessed using both model and human observers. The detectability of the disk and lesion signals was then measured using five types of model observers including the prewhitening ideal observer, the nonprewhitening (NPW) observer, the nonprewhitening observer with eye filter and internal noise (NPWEi), the prewhitening observer with eye filter and internal noise (PWEi), and the channelized Hotelling observer (CHO). The same objects were also evaluated by four human observers using the two-alternative forced choice method. The results from the model observer experiment were quantitatively compared to the human observer results to assess the correlation between the two techniques.Results: The contrast-to-detail (CD) curve generated by the human observers for the disk-detection experiments shows that the required contrast to detect a disk is inversely proportional to the square root of the disk size. Based on the CD curves, the ideal and NPW observers tend to systematically overestimate the performance of the human observers. The NPWEi and PWEi observers did not predict human performance well either, as the slopes of their CD curves tended to be steeper. The CHO generated the best quantitative agreement with human observers with its CD curve overlapping with that of human observer. Statistical equivalence between CHO and humans can be claimed within 11% of the human observer results, including both the disk and lesion detection experiments.Conclusions: The model observer method can be used to accurately represent human observer performance with the stochastic DPC-CT noise for SKE tasks with sizes ranging from 8 to 128 pixels. The incorporation of the anatomical noise remains to be studied.

  20. Sci—Fri AM: Mountain — 04: Label-free Raman spectroscopy of single tumour cells detects early radiation-induced glycogen synthesis associated with increased radiation resistance

    SciTech Connect (OSTI)

    Matthews, Q; Lum, JJ; Isabelle, M; Harder, S; Jirasek, A; Brolo, AG

    2014-08-15

    Purpose: To use label-free Raman spectroscopy (RS) for early treatment monitoring of tumour cell radioresistance. Methods: Three human tumour cell lines, two radioresistant (H460, SF{sub 2} = 0.57 and MCF7, SF{sub 2} = 0.70) and one radiosensitive (LNCaP, SF{sub 2} = 0.36), were irradiated with single fractions of 2, 4, 6, 8 or 10 Gy. In additional experiments, H460 and MCF7 cells were irradiated under co-treatment with the anti-diabetic drug metformin, a known radiosensitizing agent. Treated and control cultures were analyzed with RS daily for 3 days post-treatment. Single-cell Raman spectra were acquired from 20 live cells per sample, and experiments were repeated in triplicate. The combined data sets were analyzed with principal component analysis using standard algorithms. Cells from each culture were also subjected to standard assays for viability, proliferation, cell cycle, and radiation clonogenic survival. Results: The radioresistant cells (H460, MCF7) exhibited a RS molecular radiation response signature, detectable as early as 1 day post-treatment, of which radiation-induced glycogen synthesis is a significant contributor. The radiosensitive cells (LNCaP) exhibited negligible glycogen synthesis. Co-treatment with metformin in MCF7 cells blocked glycogen synthesis, reduced viability and proliferation, and increased radiosensitivity. Conversely, metformin co-treatment in H460 cells did not produce these same effects; importantly, both radiation-induced synthesis of glycogen and radiosensitivity were unaffected. Conclusions: Label-free RS can detect early glycogen synthesis post-irradiation, a previously undocumented metabolic mechanism associated with tumour cell radioresistance that can be targeted to increase radiosensitivity. RS monitoring of intratumoral glycogen may provide new opportunities for personalized combined modality radiotherapy treatments.

  1. IRRADIATION EXPERIMENTS &

    E-Print Network [OSTI]

    McDonald, Kirk

    IRRADIATION EXPERIMENTS & FACILITIES AT BNL: BLIP & NSLS II Peter Wanderer Superconducting MagnetV). Simultaneous irradiation and isotope production by increasing beam energy, placing irradiation target ahead of isotope production target · 117 Mev 140, 160, 180, 202 MeV · Irradiation at room temperature Alternative

  2. Plutonium radiation surrogate

    DOE Patents [OSTI]

    Frank, Michael I. (Dublin, CA)

    2010-02-02

    A self-contained source of gamma-ray and neutron radiation suitable for use as a radiation surrogate for weapons-grade plutonium is described. The source generates a radiation spectrum similar to that of weapons-grade plutonium at 5% energy resolution between 59 and 2614 keV, but contains no special nuclear material and emits little .alpha.-particle radiation. The weapons-grade plutonium radiation surrogate also emits neutrons having fluxes commensurate with the gamma-radiation intensities employed.

  3. Basic non-linear effects in silicon radiation detector in detection of highly ionizing particles: registration of ultra rare events of superheavy nuclei in the long-term experiments

    E-Print Network [OSTI]

    Tsyganov, Y S

    2015-01-01

    Sources of non-linear response of PIPS detector, when detecting highly ionizing particles like recoils (EVR), fission fragments and heavy ions, including formation of large pulse-height defect (PHD) are considered. An analytical formula to calculate the recombination component of EVR PHD is proposed on the base of surface recombination model with some empirical correction. PC-based simulation code for generating the spectrum of the measured recoil signal amplitudes of the heavy implanted nuclei is presented. The simulated spectra are compared with the experimental ones for the different facilities: the Dubna Gas Filled Recoil Separator (DGFRS), SHIP and RIKEN gas-filled separator. After the short reviewing of the detection system of the DGFRS, is considered the real-time matrix algorithm application aimed to the radical background suppression in the complete-fusion heavy-ion induced nuclear reactions. Typical examples of application in the long term experiments aimed to the synthesis of superheavy elements Z=...

  4. Polymer Composites for Radiation Scintillation

    E-Print Network [OSTI]

    Chen, Qi

    2012-01-01

    Reference G. F. Knoll, Radiation detection and measurement,MI, 1985. G. F. Knoll, Radiation detection and measurement,applications in radiation detection. First, a brief review

  5. WI Radiation Protection

    Broader source: Energy.gov [DOE]

    This statute seeks to regulate radioactive materials, to encourage the constructive uses of radiation, and to prohibit and prevent exposure to radiation in amounts which are or may be detrimental...

  6. Maryland Radiation Act (Maryland)

    Broader source: Energy.gov [DOE]

    The policy of the state is to provide for the constructive use of radiation and control radiation emissions. This legislation authorizes the Department of the Environment to develop comprehensive...

  7. Proteomic Analysis of Low Dose Arsenic and Ionizing Radiation Exposure on Keratinocytes

    E-Print Network [OSTI]

    Rocke, David M.

    Proteomic Analysis of Low Dose Arsenic and Ionizing Radiation Exposure on Keratinocytes Susanne R that keratinocytes responded to either low dose arsenic and/or low dose ionizing radiation exposure, resulting arsenic; human; ionizing radiation; keratinocyte; low dose *Corresponding author: Susanne Berglund

  8. RADIATION RESEARCH 169, 2837 (2008) 0033-7587/08 $15.00

    E-Print Network [OSTI]

    Jerby, Eli

    2008-01-01

    Peripheral Blood Lymphocytes to Radiofrequency Electromagnetic Fields for 72 Hours. Radiat. Res. 169, 2828 RADIATION RESEARCH 169, 28­37 (2008) 0033-7587/08 $15.00 2008 by Radiation Research Society. All In Vitro Exposure of Human Peripheral Blood Lymphocytes to Radiofrequency Electromagnetic Fields for 72

  9. Near-Field Radiative Heat Transfer between Macroscopic Planar Surfaces R. S. Ottens,1

    E-Print Network [OSTI]

    Tanner, David B.

    Near-Field Radiative Heat Transfer between Macroscopic Planar Surfaces R. S. Ottens,1 V. Quetschke-field, blackbody radiation. Although heat transfer via near-field effects has been discussed for many years.014301 PACS numbers: 44.40.+a, 78.20.Ci Humans knew of radiative heat transfer at least as early

  10. Reception of longitudinal vector potential radiation with a plasma antenna

    SciTech Connect (OSTI)

    Zimmerman, Robert K. Jr.

    2013-07-28

    To help resolve the long-running debate between physicists and engineers regarding the existence of the magnetic vector potential, herewith we describe an experiment demonstrating reception of time-harmonic vector potential radiation at 1.3 GHz.

  11. Geometric phase shift for detection of gravitational radiation

    E-Print Network [OSTI]

    N V Mitskievich; A I Nesterov

    2004-03-09

    An effect of geometrical phase shift is predicted for a light beam propagating in the field of a gravitational wave. Gravitational radiation detection experiments are proposed using this new effect, the corresponding estimates being given.

  12. Radiation protection at CERN

    E-Print Network [OSTI]

    Forkel-Wirth, Doris; Silari, Marco; Streit-Bianchi, Marilena; Theis, Christian; Vincke, Heinz; Vincke, Helmut

    2013-01-01

    This paper gives a brief overview of the general principles of radiation protection legislation; explains radiological quantities and units, including some basic facts about radioactivity and the biological effects of radiation; and gives an overview of the classification of radiological areas at CERN, radiation fields at high-energy accelerators, and the radiation monitoring system used at CERN. A short section addresses the ALARA approach used at CERN.

  13. THE VEX RADIATION MODULE: 2D RADIATION TRANSPORT WITH MIMETIC...

    Office of Scientific and Technical Information (OSTI)

    THE VEX RADIATION MODULE: 2D RADIATION TRANSPORT WITH MIMETIC DIFFUSION FOR EXAFLAG Citation Details In-Document Search Title: THE VEX RADIATION MODULE: 2D RADIATION TRANSPORT WITH...

  14. Timescales of Massive Human Entrainment

    E-Print Network [OSTI]

    Fusaroli, Riccardo; Mislove, Alan; Paxton, Alexandra; Matlock, Teenie; Dale, Rick

    2014-01-01

    The past two decades have seen an upsurge of interest in the collective behaviors of complex systems composed of many agents. In this paper, we extend concepts of entrainment to the dynamics of human collective attention. We demonstrate that large scale human entrainment may hold across a number of distinct scales, in an exquisitely time locked fashion. Using a large scale database of human communication data, we analyze and describe three different time scales of human entrainment in electronic media. We sought a distinct shared experience that provided a test bed for quantifying large scale human entrainment. We conducted a detailed investigation of the real time unfolding of human entrainment, as expressed by the content and patterns of hundreds of thousands of messages on Twitter, during the 2012 US presidential debates. By time locking these data sources, we quantify the real time impact of the debate on human attention. We show that social behavior covaries second by second to the interactional dynamics...

  15. Basic non-linear effects in silicon radiation detector in detection of highly ionizing particles: registration of ultra rare events of superheavy nuclei in the long-term experiments

    E-Print Network [OSTI]

    Y. S. Tsyganov

    2015-06-08

    Sources of non-linear response of PIPS detector, when detecting highly ionizing particles like recoils (EVR), fission fragments and heavy ions, including formation of large pulse-height defect (PHD) are considered. An analytical formula to calculate the recombination component of EVR PHD is proposed on the base of surface recombination model with some empirical correction. PC-based simulation code for generating the spectrum of the measured recoil signal amplitudes of the heavy implanted nuclei is presented. The simulated spectra are compared with the experimental ones for the different facilities: the Dubna Gas Filled Recoil Separator (DGFRS), SHIP and RIKEN gas-filled separator. After the short reviewing of the detection system of the DGFRS, is considered the real-time matrix algorithm application aimed to the radical background suppression in the complete-fusion heavy-ion induced nuclear reactions. Typical examples of application in the long term experiments aimed to the synthesis of superheavy elements Z=112-118 are presented [1-9].

  16. RADIONUCLIDE RADIATION PROTECTION

    E-Print Network [OSTI]

    Zakhor, Avideh

    RADIONUCLIDE AND RADIATION PROTECTION DATA HANDBOOK 2002 D. Delacroix* J. P. Guerre** P. Leblanc'Energie Atomique, CEA/Saclay, France ISBN 1 870965 87 6 RADIATION PROTECTION DOSIMETRY Vol. 98 No 1, 2002 Published by Nuclear Technology Publishing #12;RADIONUCLIDE AND RADIATION PROTECTION DATA HANDBOOK 2nd Edition (2002

  17. Harvesting nanoscale thermal radiation using pyroelectric materials

    E-Print Network [OSTI]

    Fang, Jin; Frederich, Hugo; Pilon, Laurent

    2010-01-01

    eld radiative heat transfer dominates radiation transferstudy Far field radiation Heat transfer coefficient, h r (W/nanoscale radiation to enhance radiative heat transfer. The

  18. JOSA COMMUNICATIONS Terahertz radiation from magnetoresistive

    E-Print Network [OSTI]

    Tonouchi, Masayoshi

    the output THz radiation power, whereas the effect of the co- planar transmission lines should be considered experiments, coplanar transmission lines with the bow-tie antenna are mainly used to take out THz ra- diation strong electric fields Noriaki Kida and Masayoshi Tonouchi Institute of Laser Engineering, Osaka

  19. Polymer Quantization predicts radiation in inertial frames

    E-Print Network [OSTI]

    Kajuri, Nirmalya

    2015-01-01

    We investigate the response of an Unruh-DeWitt detector coupled to a polymer quantized massless scalar field in flat spacetime, using the propagator obtained by Hossain, Husain and Seahra. As this propagator violates Lorentz invariance, frames moving at different constant velocities are no longer equivalent. This means that it is possible in principle for even an observer moving at constant velocity to detect radiation. We show that such an observer indeed detects radiation. Remarkably, we show that the rate of this radiation does not decrease with the decrease in the characteristic length scale of polymer quantization. Thus the radiation cannot be suppressed by making the polymer length scale arbitrarily small. Our results should bring this theory within the ambit of low-energy experiments and place a lower limit on the characteristic polymer length scale.

  20. Polymer Quantization predicts radiation in inertial frames

    E-Print Network [OSTI]

    Nirmalya Kajuri

    2015-08-04

    We investigate the response of an Unruh-DeWitt detector coupled to a polymer quantized massless scalar field in flat spacetime, using the propagator obtained by Hossain, Husain and Seahra. As this propagator violates Lorentz invariance, frames moving at different constant velocities are no longer equivalent. This means that it is possible in principle for even an observer moving at constant velocity to detect radiation. We show that such an observer indeed detects radiation. Remarkably, we show that the rate of this radiation does not decrease with the decrease in the characteristic length scale of polymer quantization. Thus the radiation cannot be suppressed by making the polymer length scale arbitrarily small. Our results should bring this theory within the ambit of low-energy experiments and place a lower limit on the characteristic polymer length scale.

  1. Can we detect "Unruh radiation" in the high intensity lasers?

    E-Print Network [OSTI]

    Satoshi Iso; Yasuhiro Yamamoto; Sen Zhang

    2011-02-23

    An accelerated particle sees the Minkowski vacuum as thermally excited, which is called the Unruh effect. Due to an interaction with the thermal bath, the particle moves stochastically like the Brownian motion in a heat bath. It has been discussed that the accelerated charged particle may emit extra radiation (the Unruh radiation) besides the Larmor radiation, and experiments are under planning to detect such radiation by using ultrahigh intensity lasers. There are, however, counterarguments that the radiation is canceled by an interference effect between the vacuum fluctuation and the radiation from the fluctuating motion. In this reports, we review our recent analysis on the issue of the Unruh radiation. In this report, we particularly consider the thermalization of an accelerated particle in the scalar QED, and derive the relaxation time of the thermalization.

  2. A Natural Experiment on Innovation Without Patents

    E-Print Network [OSTI]

    Torrance, Andrew W.

    2015-05-07

    experiment to take place in which innovation may operate without interference from new patent rights. Far from a desire to foster user and open innovation in human-related biotechnology, the primary rationale for this amendment to the Patent Act was strong... repugnance to biological research leading to, and the possibility of resultant ownership interests in, inventions involving human beings. Rather, it is incidental that this natural experiment may provide valuable insight into how patents affect innovation...

  3. GE's Arnie Lund Discusses User Experience at an Industrial Scale...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in user experience, the resurgence of artificial intelligence, and the challenges of big data. Lund has spent over two decades in the field of human and computer interaction...

  4. Human Computation Must Be Reproducible Praveen Paritosh

    E-Print Network [OSTI]

    Tomkins, Andrew

    and evaluation of experiments. We argue that human computation has similar properties, and that the resultsHuman Computation Must Be Reproducible Praveen Paritosh Google 345 Spear St, San Francisco, CA 94105. pkp@google.com ABSTRACT Human computation is the technique of performing a com- putational

  5. Radiation Safety (Revised March 2010)

    E-Print Network [OSTI]

    of radiation and a unit of exposure 14 Biological effects of radiation and units of dose 19 ALARA policy

  6. Synchrotron Radiation in Polymer Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Synchrotron Radiation in Polymer Science Synchrotron Radiation in Polymer Science March 30-April 2, 2012; San Francisco...

  7. TERSat: Trapped Energetic Radiation Satellite

    E-Print Network [OSTI]

    Clements, Emily B.

    2012-01-01

    Radiation damage caused by interactions with high-energy particles in the Van Allen Radiation Belts is a leading

  8. Polymer Composites for Radiation Scintillation

    E-Print Network [OSTI]

    Chen, Qi

    2012-01-01

    Principles of radiation interaction in matter and detection,Principles of radiation interaction in matter and detection,

  9. In-vitro Study of the Dielectric Effects of X-Ray on Whole Human Blood

    SciTech Connect (OSTI)

    Bernal-Alvarado, Jesus; Sanchez, Antonio; Gutierrez, Gilberto; Sosa, Modesto [Institute of Physics, University of Guanajuato, Leon (Mexico); Hernandez, Francisco [Physics and Mathematic Sciences Faculty, Autonomous University of Nuevo Leon, Monterrey (Mexico); Marquez, Sergio; Sotelo, Fernando [Research Institute on Work, University of Guanajuato, Leon (Mexico); Palomares, Pascual [Guanajuato State Transfusion Center, Leon (Mexico)

    2006-09-08

    A comparative study was done to investigate the effects of the x-radiation on the electric properties of whole human blood, from healthy people. The x-ray source was set to 55 kV and 75 kV, in order to investigate power level effects on the samples. Short and long time effects were also investigated. This experiment used a Solartron spectrometer to obtain the impedance response. No differences were found when samples were studied in the order of days (from one to five days), independently of the power level. Only in the case of 75 kV, in the power of the x-ray source, were detected significant differences between the dielectric properties of the blood, exposed to radiation, and its control sample, provided that the impedance spectrum were registered immediately after the exposure (after 15 or less minutes)

  10. Melatonin Protects Human Cells from Clustered DNA Damages, Killing and Acquisition of Soft Agar Growth Induced by X-rays or 970 MeV/n Fe ions

    SciTech Connect (OSTI)

    Das, B.; Sutherland, B.; Bennett, P. V.; Cutter, N. C.; Sutherland, J. C.

    2011-06-01

    We tested the ability of melatonin (N-acetyl-5 methoxytryptamine), a highly effective radical scavenger and human hormone, to protect DNA in solution and in human cells against induction of complex DNA clusters and biological damage induced by low or high linear energy transfer radiation (100 kVp X-rays, 970 MeV/nucleon Fe ions). Plasmid DNA in solution was treated with increasing concentrations of melatonin (0.0-3.5 mM) and were irradiated with X-rays. Human cells (28SC monocytes) were also irradiated with X-rays and Fe ions with and without 2 mM melatonin. Agarose plugs containing genomic DNA were subjected to Contour Clamped Homogeneous Electrophoretic Field (CHEF) followed by imaging and clustered DNA damages were measured by using Number Average length analysis. Transformation experiments on human primary fibroblast cells using soft agar colony assay were carried out which were irradiated with Fe ions with or without 2 mM melatonin. In plasmid DNA in solution, melatonin reduced the induction of single- and double-strand breaks. Pretreatment of human 28SC cells for 24 h before irradiation with 2 mM melatonin reduced the level of X-ray induced double-strand breaks by {approx}50%, of abasic clustered damages about 40%, and of Fe ion-induced double-strand breaks (41% reduction) and abasic clusters (34% reduction). It decreased transformation to soft agar growth of human primary cells by a factor of 10, but reduced killing by Fe ions only by 20-40%. Melatonin's effective reduction of radiation-induced critical DNA damages, cell killing, and striking decrease of transformation suggest that it is an excellent candidate as a countermeasure against radiation exposure, including radiation exposure to astronaut crews in space travel.

  11. ORIGINAL PAPER The effect of low dose rate on metabolomic response to radiation

    E-Print Network [OSTI]

    Brenner, David Jonathan

    ORIGINAL PAPER The effect of low dose rate on metabolomic response to radiation in mice Maryam assessment. Keywords Metabolomics Á Low dose rate radiation Á Mass spectrometry Introduction The adverse at high dose rates (HDR), but many will experience exposure to low dose rate (LDR) radiation from fallout

  12. RHOBOT: Radiation hardened robotics

    SciTech Connect (OSTI)

    Bennett, P.C.; Posey, L.D.

    1997-10-01

    A survey of robotic applications in radioactive environments has been conducted, and analysis of robotic system components and their response to the varying types and strengths of radiation has been completed. Two specific robotic systems for accident recovery and nuclear fuel movement have been analyzed in detail for radiation hardness. Finally, a general design approach for radiation-hardened robotics systems has been developed and is presented. This report completes this project which was funded under the Laboratory Directed Research and Development program.

  13. Radiation Hazards Program (Minnesota)

    Broader source: Energy.gov [DOE]

    These regulations, promulgated by the Department of Health, set allowable radiation standards and mitigation practices, as well as procedures for the transportation of hazardous material.

  14. Atomic Radiation (Illinois)

    Broader source: Energy.gov [DOE]

    This article states permissible levels of radiation in unrestricted areas, environmental standards for uranium fuel cycle and information about notification of incidents.

  15. TH-A-BRD-01: Radiation Biology for Radiation Therapy Physicists

    SciTech Connect (OSTI)

    Orton, C; Borras, C; Carlson, D

    2014-06-15

    Mechanisms by which radiation kills cells and ways cell damage can be repaired will be reviewed. The radiobiological parameters of dose, fractionation, delivery time, dose rate, and LET will be discussed. The linear-quadratic model for cell survival for high and low dose rate treatments and the effect of repopulation will be presented and discussed. The rationale for various radiotherapy techniques such as conventional fractionation, hyperfractionation, hypofractionation, and low and high dose rate brachytherapy, including permanent implants, will be presented. The radiobiological principles underlying radiation protection guidelines and the different radiation dosimetry terms used in radiation biology and in radiation protection will be reviewed. Human data on radiation induced cancer, including increases in the risk of second cancers following radiation therapy, as well as data on radiation induced tissue reactions, such as cardiovascular effects, for follow up times up to 20–40 years, published by ICRP, NCRP and BEIR Committees, will be examined. The latest risk estimates per unit dose will be presented. Their adoption in recent radiation protection standards and guidelines and their impact on patient and workers safety in radiotherapy will be discussed. Biologically-guided radiotherapy (BGRT) provides a systematic method to derive prescription doses that integrate patient-specific information about tumor and normal tissue biology. Treatment individualization based on patient-specific biology requires the identification of biological objective functions to facilitate the design and comparison of competing treatment modalities. Biological objectives provide a more direct approach to plan optimization instead of relying solely on dose-based surrogates and can incorporate factors that alter radiation response, such as DNA repair, tumor hypoxia, and relative biological effectiveness. We review concepts motivating biological objectives and provide examples of how they might be used to address clinically relevant problems. Underlying assumptions and limitations of existing models and their proper application will be discussed. This multidisciplinary educational session combines the fundamentals of radiobiology for radiation therapy and radiation protection with the practical application of biophysical models for treatment planning and evaluation. Learning Objectives: To understand fractionation in teletherapy and dose rate techniques in brachytherapy. To understand how the linear-quadratic models the effect of radiobiological parameters for radiotherapy. To understand the radiobiological basis of radiation protection standards applied to radiotherapy. To distinguish between stochastic effects and tissue reactions. To learn how to apply concepts of biological effective dose and RBE-weighted dose and to incorporate biological factors that alter radiation response. To discuss clinical strategies to increase therapeutic ratio, i.e., maximize local control while minimizing the risk of acute and late normal tissue effects.

  16. Radiation physics, biophysics, and radiation biology

    SciTech Connect (OSTI)

    Hall, E.J.

    1992-05-01

    The following research programs from the Center for Radiological Research of Columbia University are described: Design and development of a new wall-less ultra miniature proportional counter for nanodosimetry; some recent measurements of ionization distributions for heavy ions at nanometer site sizes with a wall-less proportional counter; a calculation of exciton energies in periodic systems with helical symmetry: application to a hydrogen fluoride chain; electron energy-loss function in polynucleotide and the question of plasmon excitation; a non-parametric, microdosimetric-based approach to the evaluation of the biological effects of low doses of ionizing radiation; high-LET radiation risk assessment at medium doses; high-LET radiobiological effects: increased lesion severity or increased lesion proximity; photoneutrons generated by high energy medical linacs; the biological effectiveness of neutrons; implications for radiation protection; molecular characterization of oncogenes induced by neutrons; and the inverse dose-rate effect for oncogenic transformation by charged particles is LET dependent.

  17. Single electron detection and spectroscopy via relativistic cyclotron radiation

    E-Print Network [OSTI]

    D. M. Asner; R. F. Bradley; L. de Viveiros; P. J. Doe; J. L. Fernandes; M. Fertl; E. C. Finn; J. A. Formaggio; D. Furse; A. M. Jones; J. N. Kofron; B. H. LaRoque; M. Leber; E. L. McBride; M. L. Miller; P. Mohanmurthy; B. Monreal; N. S. Oblath; R. G. H. Robertson; L. J Rosenberg; G. Rybka; D. Rysewyk; M. G. Sternberg; J. R. Tedeschi; T. Thummler; B. A. VanDevender; N. L. Woods

    2015-05-01

    It has been understood since 1897 that accelerating charges must emit electromagnetic radiation. Cyclotron radiation, the particular form of radiation emitted by an electron orbiting in a magnetic field, was first derived in 1904. Despite the simplicity of this concept, and the enormous utility of electron spectroscopy in nuclear and particle physics, single-electron cyclotron radiation has never been observed directly. Here we demonstrate single-electron detection in a novel radiofrequency spec- trometer. We observe the cyclotron radiation emitted by individual magnetically-trapped electrons that are produced with mildly-relativistic energies by a gaseous radioactive source. The relativistic shift in the cyclotron frequency permits a precise electron energy measurement. Precise beta elec- tron spectroscopy from gaseous radiation sources is a key technique in modern efforts to measure the neutrino mass via the tritium decay endpoint, and this work demonstrates a fundamentally new approach to precision beta spectroscopy for future neutrino mass experiments.

  18. Solar Dynamics Observatory/ Extreme Ultraviolet Variability Experiment

    E-Print Network [OSTI]

    Mojzsis, Stephen J.

    Solar Dynamics Observatory/ EVE Extreme Ultraviolet Variability Experiment Frequently Asked and model solar extreme ultraviolet irradiance variations due to solar flares, solar rotation, and solar and structure of the Sun. What is solar variability? Solar radiation varies on all time scales ranging from

  19. ON THE JITTER RADIATION

    SciTech Connect (OSTI)

    Kelner, S. R. [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, D-6917 Heidelberg (Germany); Aharonian, F. A. [Dublin Institute for Advanced Studies, 31 Fitzwilliam Place, Dublin 2 (Ireland); Khangulyan, D., E-mail: skelner@rambler.ru, E-mail: Felix.Aharonian@mpi-hd.mpg.de, E-mail: khangul@astro.isas.jaxa.jp [Institute of Space and Astronautical Science/JAXA, 3-1-1 Yoshinodai, Chuo-ku, Sagamihara, Kanagawa 252-5210 (Japan)

    2013-09-01

    In a small-scale turbulent medium, when the nonrelativistic Larmor radius R{sub L} = mc {sup 2}/eB exceeds the correlation length {lambda} of the magnetic field, the magnetic Bremsstrahlung radiation of charged relativistic particles unavoidably proceeds to the so-called jitter radiation regime. The cooling timescale of parent particles is identical to the synchrotron cooling time, thus this radiation regime can be produced with very high efficiency in different astrophysical sources characterized by high turbulence. The jitter radiation has distinct spectral features shifted toward high energies, compared to synchrotron radiation. This effect makes the jitter mechanism an attractive broad-band gamma-ray production channel, which, in highly magnetized and turbulent environments, can compete or even dominate over other high-energy radiation mechanisms. In this paper, we present a novel study of the spectral properties of the jitter radiation performed within the framework of perturbation theory. The derived general expression for the spectral power of radiation is presented in a compact and convenient form for numerical calculations.

  20. Radiative Flux Analysis

    SciTech Connect (OSTI)

    Long, Chuck

    2008-05-14

    The Radiative Flux Analysis is a technique for using surface broadband radiation measurements for detecting periods of clear (i.e. cloudless) skies, and using the detected clear-sky data to fit functions which are then used to produce continuous clear-sky estimates. The clear-sky estimates and measurements are then used in various ways to infer cloud macrophysical properties.

  1. Radiation-resistant microorganism

    DOE Patents [OSTI]

    Fliermans, Carl B.

    2010-06-15

    An isolated and purified bacterium is provided which was isolated from a high-level radioactive waste site of mixed waste. The isolate has the ability to degrade a wide variety of organic contaminants while demonstrating high tolerance to ionizing radiation. The organism is uniquely suited to bioremediation of a variety or organic contaminants while in the presence of ionizing radiation.

  2. Photochemistry Radiation and Photolysis

    E-Print Network [OSTI]

    Toohey, Darin W.

    energy is done (i.e. energy per unit time) #12;Sample Problem: A microwave oven puts out radiation at 50? How does a microwave oven heat food anyway? First note that 50 GHz is a frequency (Hz = s-1) E = hn, as a function of l · Amount of solar radiation, as a function of

  3. Wide-cross whole-genome radiation hybrid (WWRH) mapping and identification of cold-responsive genes using oligo-gene microarray analysis in cotton 

    E-Print Network [OSTI]

    Gao, Wenxiang

    2005-02-17

    The first part of this research focused on wide-cross whole-genome radiation hybrid (WWRH) mapping of the cotton (Gossypium) genome. Radiation hybrid mapping has been used extensively to map the genomes of human and certain animal species...

  4. THE GEOSTATIONARY EARTH RADIATION BUDGET (GERB) EXPERIMENT: SCIENCE AND APPLICATIONS

    E-Print Network [OSTI]

    Allan, Richard P.

    of the variations in the ERB at shorter #12;timescales. By measuring the reflected solar and emitted thermal energy of rapidly varying climate processes (e.g. diurnal convection over Africa) to be resolved. GERB data 1. INTRODUCTION Understanding the processes that control the natural stability and variability

  5. Experiment Number 19 The Transmission of -Radiation Through Matter

    E-Print Network [OSTI]

    is the Avogadro's number is the density so that the probability of a certain electron being scattered is very

  6. Atmospheric Radiation Measurement Tropical Warm Pool International Cloud Experiment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D B L O O DBiomass and BiofuelsPhysicist47July 1999

  7. ARM - Field Campaign - Macquarie Island Cloud and Radiation Experiment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach HomeA Better Anode Design togovCampaignsMASRAD: Pt. Reyes Stratus Cloud and(MICRE)

  8. ARM - Field Campaign - The ARM Pilot Radiation Observation Experiment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach HomeA Better Anode DesigngovCampaignsSpring Single Column Model IOP(PROBE) govCampaignsThe ARM Pilot

  9. ARM West Antarctic Radiation Experiment (AWARE) Science Plan

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News Publications Traditional Knowledge Kiosks Barrow, AlaskaDatabaseSearchTipsWith the3 An0

  10. ARM - Field Campaign - ARM West Antarctic Radiation Experiment AWARE:

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Comments? WeDatastreamstps DocumentationAtlanticENA ContactsProductsSACR26, 2015

  11. ARM West Antarctic Radiation Experiment (AWARE) Science Plan (Program

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield MunicipalTechnicalInformation4563 LLNL(Technicalentanglements forusingandclustersDocument)

  12. ARM West Antarctic Radiation Experiment (AWARE) Science Plan (Program

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield MunicipalTechnicalInformation4563 LLNL(Technicalentanglements forusingandclustersDocument)Document)

  13. Operating Experience Level 3, DOE Occupational Radiation Exposures for 2013

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on DeliciousMathematicsEnergyInterested Parties -DepartmentAvailableHighOffice ofProjectDepartmentOperating

  14. Macquarie Island Cloud and Radiation Experiment (MICRE) Science Plan

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesse BergkampCentermillion toMSDS on the internet The Office

  15. Appendix G. Radiation Appendix G. Radiation

    E-Print Network [OSTI]

    Pennycook, Steve

    energy, is energy in the form of waves or particles moving through space. Visi- ble light, heat, radio in the form of electromagnetic waves. Examples include gamma rays, ultraviolet light, and radio waves waves, and alpha particles are examples of radiation. When people feel warmth from sunlight

  16. Issues in Low Dose Radiation Biology: The Controversy Continues. A Perspective

    SciTech Connect (OSTI)

    Morgan, William F.; Bair, William J.

    2013-05-01

    Both natural and man-made sources of ionizing radiation contribute to human exposure and consequently pose a risk to human health. Much of this is unavoidable, e.g., natural background radiation, and as the use of radiation in modern medicine and industry increases so does the potential health risk. This perspective reflects the author’s view of current issues in low dose radiation biology research, highlights some of the controversies therein, and suggests areas of future research to address these issues. The views expressed here are the authors own and do not represent any institution, organization or funding body.

  17. Irradiation Effects on Human Cortical Bone Fracture Behavior

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high...

  18. Radiation Damage in Polarized Ammonia Solids

    E-Print Network [OSTI]

    K. Slifer

    2007-11-28

    Solid NH3 and ND3 provide a highly polarizable, radiation resistant source of polarized protons and deuterons and have been used extensively in high luminosity experiments investigating the spin structure of the nucleon. Over the past twenty years, the UVA polarized target group has been instrumental in producing and polarizing much of the material used in these studies, and many practical considerations have been learned in this time. In this discussion, we analyze the polarization performance of the solid ammonia targets used during the recent JLab Eg4 run. Topics include the rate of polarization decay with accumulated charge, the annealing procedure for radiation damaged targets to recover polarization, and the radiation induced change in optimum microwave frequency used to polarize the sample. We also discuss the success we have had in implementing frequency modulation of the polarizing microwave frequency.

  19. Neutralizing Polyclonal IgG Present during Acute Infection Prevents Rapid Disease Onset in Simian-Human Immunodeficiency Virus SHIVSF162P3-Infected Infant Rhesus Macaques

    E-Print Network [OSTI]

    2013-01-01

    human NMAbs with potent, broad activity to be used along with antiretroviral therapy (ART). Such experiments

  20. An Agent-Based System Assisting Humans in Complex Tasks by Analysis of a Human's State and Performance

    E-Print Network [OSTI]

    Treur, Jan

    becomes too high, the agent can assist the human in a number of ways. Experiments show that the supportAn Agent-Based System Assisting Humans in Complex Tasks by Analysis of a Human's State, michael}@forcevisionlab.nl Abstract Human task performance varies depending on the task, environment

  1. RADIATION DAMAGE OF GERMANIUM DETECTORS

    E-Print Network [OSTI]

    Pehl, Richard H.

    2011-01-01

    occurring within the detector, radiation may also change theLBL-7967 RADIATION DAMAGE OF GERMANIUM DETECTORS Richard H.LBL-7967 RADIATION DAMAGE OF GERMANIUM DETECTORS* Richard H.

  2. Space Radiation and Cataracts (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Blakely, Eleanor

    2011-04-28

    Summer Lecture Series 2009: Eleanor Blakely, radiation biologist of the Life Sciences Division at Lawrence Berkeley National Laboratory, has been a scientist at Berkeley Lab since 1975. She is studying the effect of radiation on cataracts which concerns not only cancer patients, but also astronauts. As astronauts spend increasingly longer time in space, the effects of cosmic radiation exposure will become an increasingly important health issue- yet there is little human data on these effects. Blakely reviews this emerging field and the contributions made at Berkeley Lab

  3. More about excited bottomonium radiative decays

    E-Print Network [OSTI]

    Randy Lewis; R. M. Woloshyn

    2012-09-18

    Radiative decays of bottomonium are revisited, focusing on contributions from higher-order relativistic effects. The leading relativistic correction to the magnetic spin-flip operator at the photon vertex is found to be particularly important. The combination of O(v^6) effects in the nonrelativistic QCD action and in the transition operator moves previous lattice results for excited Upsilon decays into agreement with experiment.

  4. Radiation Damage/Materials Modification

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ion irradiation is an important tool for studying radiation damage effects Materials in a nuclear reactor are exposed to extreme temperature and radiation conditions that degrade...

  5. Florida Radiation Protection Act (Florida)

    Broader source: Energy.gov [DOE]

    The Department of Public Health is responsible for administering a statewide radiation protection program. The program is designed to permit development and utilization of sources of radiation for...

  6. Human Assisted Robotic Team Campaigns for Aquatic Monitoring

    E-Print Network [OSTI]

    2007-01-01

    W. J. (2007a). Autonomous robotic sensing experiments at sanand development of a wireless robotic networked aquaticHuman Assisted Robotic Team Campaigns for Aquatic Monitoring

  7. Radiation Safety System

    SciTech Connect (OSTI)

    Vylet, Vaclav; Liu, James C.; Walker, Lawrence S.; /Los Alamos

    2012-04-04

    The goal of this work is to provide an overview of a Radiation safety system (RSS) designed for protection from prompt radiation hazard at accelerator facilities. RSS design parameters, functional requirements and constraints are derived from hazard analysis and risk assessment undertaken in the design phase of the facility. The two main subsystems of a RSS are access control system (ACS) and radiation control system (RCS). In this text, a common approach to risk assessment, typical components of ACS and RCS, desirable features and general design principles applied to RSS are described.

  8. Composition for radiation shielding

    DOE Patents [OSTI]

    Kronberg, James W. (Aiken, SC)

    1994-01-01

    A composition for use as a radiation shield. The shield has a depleted urum core for absorbing gamma rays and a bismuth coating for preventing chemical corrosion and absorbing gamma rays. Alternatively, a sheet of gadolinium may be positioned between the uranium core and the bismuth coating for absorbing neutrons. The composition is preferably in the form of a container for storing materials that emit radiation such as gamma rays and neutrons. The container is preferably formed by casting bismuth around a pre-formed uranium container having a gadolinium sheeting, and allowing the bismuth to cool. The resulting container is a structurally sound, corrosion-resistant, radiation-absorbing container.

  9. Miniaturized radiation chirper

    DOE Patents [OSTI]

    Umbarger, C. John (Los Alamos, NM); Wolf, Michael A. (Los Alamos, NM)

    1980-01-01

    The disclosure relates to a miniaturized radiation chirper for use with a small battery supplying on the order of 5 volts. A poor quality CdTe crystal which is not necessarily suitable for high resolution gamma ray spectroscopy is incorporated with appropriate electronics so that the chirper emits an audible noise at a rate that is proportional to radiation exposure level. The chirper is intended to serve as a personnel radiation warning device that utilizes new and novel electronics with a novel detector, a CdTe crystal. The resultant device is much smaller and has much longer battery life than existing chirpers.

  10. Evaluating Software Agents Using Human Robert D. Grant, Dewayne E. Perry

    E-Print Network [OSTI]

    Perry, Dewayne E.

    the way for rigorous experiments comparing their performance with human benchmarks. Method: Little agents with human benchmarks. We hope future researchers will be able to perform controlled experiments performance with human performance on "identical" curricula in controlled experiments. This paper is a more

  11. Integrating human and robot decision-making dynamics with feedback: Models and convergence analysis

    E-Print Network [OSTI]

    Leonard, Naomi

    , a well-studied decision-making task in behavioral experiments. The human subject chooses between two structures, the behavioral experiments show convergence to suboptimal choices. We propose a human- supervised and the kinds of decisions humans make in psychology experiments. We consider a class of sequential binary

  12. Quantum vacuum radiation in optical glass

    E-Print Network [OSTI]

    Stefano Liberati; Angus Prain; Matt Visser

    2011-11-01

    A recent experimental claim of the detection of analogue Hawking radiation in an optical system [PRL 105 (2010) 203901] has led to some controversy [PRL 107 (2011) 149401, 149402]. While this experiment strongly suggests some form of particle creation from the quantum vacuum (and hence it is per se very interesting), it is also true that it seems difficult to completely explain all features of the observations by adopting the perspective of a Hawking-like mechanism for the radiation. For instance, the observed photons are emitted parallel to the optical horizon, and the relevant optical horizon is itself defined in an unusual manner by combining group and phase velocities. This raises the question: Is this really Hawking radiation, or some other form of quantum vacuum radiation? Naive estimates of the amount of quantum vacuum radiation generated due to the rapidly changing refractive index --- sometimes called the dynamical Casimir effect --- are not encouraging. However we feel that naive estimates could be misleading depending on the quantitative magnitude of two specific physical effects: "pulse steepening" and "pulse cresting". Plausible bounds on the maximum size of these two effects results in estimates much closer to the experimental observations, and we argue that the dynamical Casimir effect is now worth additional investigation.

  13. How Do We Know that Human Activities Have Influenced Global Climate?

    SciTech Connect (OSTI)

    Santer, Benjamin D.

    2007-11-05

    Human activities have significantly altered not only the chemical composition of Earth's atmosphere, but also the climate system. Human influences have led to increases in well-mixed greenhouse gases, decreases in stratospheric ozone, and changes in the atmospheric burdens of sulfate and soot aerosols. All of these atmospheric constituents interact with incoming solar and outgoing terrestrial radiation. Human-induced changes in the concentrations of these constituents modify the natural radiative balance of Earth's atmosphere, and therefore perturb climate. Quantifying the size of the human effect on climate is a difficult statistical problem. 'Fingerprint' methods are typically used for this purpose. These methods involve rigorous statistical comparisons of modeled and observed climate change patterns. Fingerprinting assumes that each individual influence on climate has a unique signature in climate records. The climate fingerprints in response to different forcing factors are typically estimated with computer models, which can be used to perform the controlled experiments that we cannot conduct in the real world. One criticism of the findings of previous scientific assessments is that they have relied heavily on fingerprint studies involving changes in near-surface temperature. Recent fingerprint work, however, has considered a variety of other climate variables, such as ocean heat content, stratospheric temperatures, Northern Hemisphere sea ice extent, sea level pressure, atmospheric water vapor, and the height of the tropopause. These studies illustrate that a human-induced climate change signal is identifiable in many different variables and geographic regions, and that the climate system is telling us an internally- and physically-consistent story.

  14. Visual Field Maps, Population Receptive Field Sizes, and Visual Field Coverage in the Human MT Complex

    E-Print Network [OSTI]

    Dumoulin, Serge O.

    of processing in human motion-selective cortex. I N T R O D U C T I O N Neuroimaging experiments localize human by additional experiments. Defining human MT based on stimulus selectivity means that the identificationVisual Field Maps, Population Receptive Field Sizes, and Visual Field Coverage in the Human MT

  15. Portal radiation monitor

    DOE Patents [OSTI]

    Kruse, L.W.

    1982-03-23

    A portal radiation monitor combines .1% FAR with high sensitivity to special nuclear material. The monitor utilizes pulse shape discrimination, dynamic compression of the photomultiplier output and scintillators sized to maintain efficiency over the entire portal area.

  16. Portal radiation monitor

    DOE Patents [OSTI]

    Kruse, Lyle W. (Albuquerque, NM)

    1985-01-01

    A portal radiation monitor combines 0.1% FAR with high sensitivity to special nuclear material. The monitor utilizes pulse shape discrimination, dynamic compression of the photomultiplier output and scintillators sized to maintain efficiency over the entire portal area.

  17. Amorphous silicon radiation detectors

    DOE Patents [OSTI]

    Street, Robert A. (Palo Alto, CA); Perez-Mendez, Victor (Berkeley, CA); Kaplan, Selig N. (El Cerrito, CA)

    1992-01-01

    Hydrogenated amorphous silicon radiation detector devices having enhanced signal are disclosed. Specifically provided are transversely oriented electrode layers and layered detector configurations of amorphous silicon, the structure of which allow high electric fields upon application of a bias thereby beneficially resulting in a reduction in noise from contact injection and an increase in signal including avalanche multiplication and gain of the signal produced by incoming high energy radiation. These enhanced radiation sensitive devices can be used as measuring and detection means for visible light, low energy photons and high energy ionizing particles such as electrons, x-rays, alpha particles, beta particles and gamma radiation. Particular utility of the device is disclosed for precision powder crystallography and biological identification.

  18. Amorphous silicon radiation detectors

    DOE Patents [OSTI]

    Street, R.A.; Perez-Mendez, V.; Kaplan, S.N.

    1992-11-17

    Hydrogenated amorphous silicon radiation detector devices having enhanced signal are disclosed. Specifically provided are transversely oriented electrode layers and layered detector configurations of amorphous silicon, the structure of which allow high electric fields upon application of a bias thereby beneficially resulting in a reduction in noise from contact injection and an increase in signal including avalanche multiplication and gain of the signal produced by incoming high energy radiation. These enhanced radiation sensitive devices can be used as measuring and detection means for visible light, low energy photons and high energy ionizing particles such as electrons, x-rays, alpha particles, beta particles and gamma radiation. Particular utility of the device is disclosed for precision powder crystallography and biological identification. 13 figs.

  19. Radiative-convective instability

    E-Print Network [OSTI]

    Wing, Allison A.

    Radiative-moist-convective equilibrium (RCE) is a simple paradigm for the statistical equilibrium the earth's climate would exhibit in the absence of lateral energy transport. It has generally been assumed that for a given ...

  20. Ionizing radiation detector

    DOE Patents [OSTI]

    Thacker, Louis H. (Knoxville, TN)

    1990-01-01

    An ionizing radiation detector is provided which is based on the principle of analog electronic integration of radiation sensor currents in the sub-pico to nano ampere range between fixed voltage switching thresholds with automatic voltage reversal each time the appropriate threshold is reached. The thresholds are provided by a first NAND gate Schmitt trigger which is coupled with a second NAND gate Schmitt trigger operating in an alternate switching state from the first gate to turn either a visible or audible indicating device on and off in response to the gate switching rate which is indicative of the level of radiation being sensed. The detector can be configured as a small, personal radiation dosimeter which is simple to operate and responsive over a dynamic range of at least 0.01 to 1000 R/hr.

  1. Method of enhancing radiation response of radiation detection materials

    DOE Patents [OSTI]

    Miller, Steven D. (Richland, WA)

    1997-01-01

    The present invention is a method of increasing radiation response of a radiation detection material for a given radiation signal by first pressurizing the radiation detection material. Pressurization may be accomplished by any means including mechanical and/or hydraulic. In this application, the term "pressure" includes fluid pressure and/or mechanical stress.

  2. Radiation Safety Training Basic Radiation Safety Training for

    E-Print Network [OSTI]

    Dai, Pengcheng

    Radiation Safety Training Basic Radiation Safety Training for X-ray Users for Physics 461 & 462 Protocol Title: Basic Radiation Safety Training for X-ray Users Drafted By: Chris Millsaps, RSS Reviewers: ZB, TU, GS Purpose: To provide basic radiation safety training to the users of x-ray producing

  3. A National Radiation Oncology Medical Student Clerkship Survey: Didactic Curricular Components Increase Confidence in Clinical Competency

    SciTech Connect (OSTI)

    Jagadeesan, Vikrant S.; Raleigh, David R.; Koshy, Matthew; Howard, Andrew R.; Chmura, Steven J.; Golden, Daniel W.

    2014-01-01

    Purpose: Students applying to radiation oncology residency programs complete 1 or more radiation oncology clerkships. This study assesses student experiences and perspectives during radiation oncology clerkships. The impact of didactic components and number of clerkship experiences in relation to confidence in clinical competency and preparation to function as a first-year radiation oncology resident are evaluated. Methods and Materials: An anonymous, Internet-based survey was sent via direct e-mail to all applicants to a single radiation oncology residency program during the 2012-2013 academic year. The survey was composed of 3 main sections including questions regarding baseline demographic information and prior radiation oncology experience, rotation experiences, and ideal clerkship curriculum content. Results: The survey response rate was 37% (70 of 188). Respondents reported 191 unique clerkship experiences. Of the respondents, 27% (19 of 70) completed at least 1 clerkship with a didactic component geared towards their level of training. Completing a clerkship with a didactic component was significantly associated with a respondent's confidence to function as a first-year radiation oncology resident (Wilcoxon rank–sum P=.03). However, the total number of clerkships completed did not correlate with confidence to pursue radiation oncology as a specialty (Spearman ? P=.48) or confidence to function as a first year resident (Spearman ? P=.43). Conclusions: Based on responses to this survey, rotating students perceive that the majority of radiation oncology clerkships do not have formal didactic curricula. Survey respondents who completed a clerkship with a didactic curriculum reported feeling more prepared to function as a radiation oncology resident. However, completing an increasing number of clerkships does not appear to improve confidence in the decision to pursue radiation oncology as a career or to function as a radiation oncology resident. These results support further development of structured didactic curricula for the radiation oncology clerkship.

  4. Handbook of radiation effects

    SciTech Connect (OSTI)

    Holmes-Siedle, A. (ed.) (Radiation Experiments and Monitors, Oxford (United Kingdom) Univ. of West London (United Kingdom)); Adams, L. (ed.) (European Space Agency-ESTEC, Noordwijk (Netherlands). Radiation Effects and Analysis Techniques Unit)

    1993-01-01

    This handbook is intended to serve as a tool for designers of equipment and scientific instruments in cases where they are required to ensure the survival of the equipment in radiation environments. High-technology materials, especially semiconductors and optics, tend to degrade on exposure to radiation in many different ways. Intense high-energy radiation environments are found in nuclear reactors and accelerators, machines for radiation therapy, industrial sterilization, and space. Some engineers have to build equipment which will survive a nuclear explosion from a hostile source. Proper handling of a disaster with radioactive materials requires equipment which depends utterly on semiconductor microelectronics and imaging devices. Thus the technology of radiation-tolerant electronics is an instrument for good social spheres as diverse as disaster planning and the exploration of Mars. In order to design equipment for intense environments like those described above, then degradation from high-energy irradiation must be seen as a basic design parameter. The aim of this handbook is to assist the engineer or student in that thought; to make it possible to write intelligent specifications; to offer some understanding of the complex variety of effects which occur when high-technology components encounter high-energy radiation; and to go thoroughly into the balance of choices of how to alleviate the effects and hence achieve the design aims of the project. Separate abstracts were prepared for 15 chapters of this book.

  5. Radiation analysis devices, radiation analysis methods, and articles of manufacture

    DOE Patents [OSTI]

    Roybal, Lyle Gene

    2010-06-08

    Radiation analysis devices include circuitry configured to determine respective radiation count data for a plurality of sections of an area of interest and combine the radiation count data of individual of sections to determine whether a selected radioactive material is present in the area of interest. An amount of the radiation count data for an individual section is insufficient to determine whether the selected radioactive material is present in the individual section. An article of manufacture includes media comprising programming configured to cause processing circuitry to perform processing comprising determining one or more correction factors based on a calibration of a radiation analysis device, measuring radiation received by the radiation analysis device using the one or more correction factors, and presenting information relating to an amount of radiation measured by the radiation analysis device having one of a plurality of specified radiation energy levels of a range of interest.

  6. Detecting relic gravitational radiation from string cosmology with LIGO

    E-Print Network [OSTI]

    Bruce Allen; Ram Brustein

    1996-09-05

    A characteristic spectrum of relic gravitational radiation is produced by a period of ``stringy inflation" in the early universe. This spectrum is unusual, because the energy-density rises rapidly with frequency. We show that correlation experiments with the two gravitational wave detectors being built for the Laser Interferometric Gravitational Observatory (LIGO) could detect this relic radiation, for certain ranges of the parameters that characterize the underlying string cosmology model.

  7. Performance studies of scintillating ceramic samples exposed to ionizing radiation

    E-Print Network [OSTI]

    Dissertori, G; Nessi-Tedaldi, F; Pauss, F; Wallny, R

    2012-01-01

    Scintillating ceramics are a promising, new development for various applications in science and industry. Their application in calorimetry for particle physics experiments is expected to involve an exposure to high levels of ionizing radiation. In this paper, changes in performance have been measured for scintillating ceramic samples of different composition after exposure to penetrating ionizing radiation up to a dose of 38 kGy.

  8. Performance studies of scintillating ceramic samples exposed to ionizing radiation

    E-Print Network [OSTI]

    G. Dissertori; D. Luckey; F. Nessi-Tedaldi; F. Pauss; R. Wallny

    2012-11-16

    Scintillating ceramics are a promising, new development for various applications in science and industry. Their application in calorimetry for particle physics experiments is expected to involve an exposure to high levels of ionizing radiation. In this paper, changes in performance have been measured for scintillating ceramic samples of different composition after exposure to penetrating ionizing radiation up to a dose of 38 kGy.

  9. COLUMBIA UNIVERSITY Radiation Safety Program

    E-Print Network [OSTI]

    Jia, Songtao

    this form to Radiation Safety's Dosimetry Program.) ___ Yes ___ No 1. Was the Dosimeter placed or stored

  10. Radiation oncogenesis in cell culture

    SciTech Connect (OSTI)

    Borek, C.

    1982-01-01

    This review article examines the oncogenic effects of radiation with emphasis on ionizing radiations. Cell transformation in vitro is examined with respect to culture systems currently used in these studies, initiation and phenotypic expression of transformation and criteria for transformation. The section of radiation oncogenesis in vitro includes ionizing and nonionizing radiation studies and cocarcinogens and modulators of radiogenic transformations.

  11. REPORT NO. 8 radiation hazards

    E-Print Network [OSTI]

    REPORT NO. 8 REVISED guidance for the control of radiation hazards in uranium mining SEPTEMBER 1967 OF RADIATION HAZARDS IN URANIUM MINING SEPTEMBER 1967 Staff Report of the FEDERAL RADIATION COUNCIL #12;FEDERAL...... .... .._ _.... Section I. Introduction. . . Section II. The Radiation Environment AssociatedWith Uranium Mining. Section

  12. SU-E-T-320: The Effect of Survivin Perturbation On the Radiation Response of Breast Cancer Cell Lines

    SciTech Connect (OSTI)

    Smith, D; Debeb, B; Woodward, W

    2014-06-01

    Purpose: Survivin is the smallest member of the inhibitor of apoptosis protein family and is well-known for its universal over-expression in human cancers. Due to its role in apoptosis and cellular proliferation, survivin is implicated in the radiation response in several cancer types, and antisurvivin treatments have had success as a radiation sensitizer in many preclinical cancer models. As no studies to date have reported survivin as a factor affecting radiation resistance in breast cancer models, we sought to evaluate the synergistic relationship between survivin function and irradiation in breast cancer cell lines. Methods: Information regarding survivin protein expression in breast cancer was retrieved from three public databases: Oncomine, Kaplan-Meier Plotter, and GOBO. For the in vitro studies, survivin function was compromised by transducing a non-functional mutant form (survivin-DN) into two breast cancer cell lines, the estrogen receptor-positive MCF7 and the triple-negative, inflammatory SUM149. Cell growth was compared in the survivin-DN and control populations with colony-formation assays. To assess how survivin affects radiation response, clonogenic assays were performed by irradiating the cell lines up to 6 Gy. Results: From the public databases, survivin is more highly expressed in triple-negative breast cancer compared to all other subtypes, and is prognostic of poor survival in all breast cancer patients. In MCF7, the survivin-DN population had decreased colony-formation potential; the opposite was true in SUM149. In the clonogenic assays, abrogation of survivin function radio-protected MCF7 cells in monolayer and 3D growth conditions, while SUM149 survivin-DN cells were radiosensitized in monolayer conditions. Conclusion: We observed synergy between survivin function and radiation, although the results between the two cell lines were disparate. Further investigation is required to identify the mechanism of this discrepancy, including evaluation of the potential role of estrogen receptor status, before proceeding with small-animal experiments.

  13. Spectral brilliance of channeling radiation at the ASTA photoinjector

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Sen, Tanaji [Fermi National Accelerator Lab., Batavia, IL (United States); Lynn, Christopher [Swarthmore College, Swarthmore, PA (United States)

    2014-12-10

    We study channeling radiation from electron beams with energies under 100 MeV. We introduce a phenomenological model of dechanneling, correct non-radiative transition rates from thermal scattering, and discuss in detail the population dynamics in low order bound states. These are used to revisit the X-ray properties measured at the ELBE facility in Forschungszentrum Dresden-Rosenstock (FZDR), extract parameters for dechanneling states, and obtain satisfactory agreement with measured photon yields. The importance of rechanneling phenomena in thick crystals is emphasized. The model is then used to calculate the expected X-ray energies, linewidths and brilliance for forthcoming channeling radiation experiments at Fermilab's ASTA photoinjector.

  14. Spectral brilliance of channeling radiation at the ASTA photoinjector

    SciTech Connect (OSTI)

    Sen, Tanaji; Lynn, Christopher

    2014-12-01

    We study channeling radiation from electron beams with energies under 100 MeV. We introduce a phenomenological model of dechanneling, correct non-radiative transition rates from thermal scattering, and discuss in detail the population dynamics in low order bound states. These are used to revisit the X-ray properties measured at the ELBE facility in Forschungszentrum Dresden-Rosenstock (FZDR), extract parameters for dechanneling states, and obtain satisfactory agreement with measured photon yields. The importance of rechanneling phenomena in thick crystals is emphasized. The model is then used to calculate the expected X-ray energies, linewidths and brilliance for forthcoming channeling radiation experiments at Fermilab's ASTA photoinjector.

  15. Spectral brilliance of channeling radiation at the ASTA photoinjector

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Sen, Tanaji; Lynn, Christopher

    2014-12-01

    We study channeling radiation from electron beams with energies under 100 MeV. We introduce a phenomenological model of dechanneling, correct non-radiative transition rates from thermal scattering, and discuss in detail the population dynamics in low order bound states. These are used to revisit the X-ray properties measured at the ELBE facility in Forschungszentrum Dresden-Rosenstock (FZDR), extract parameters for dechanneling states, and obtain satisfactory agreement with measured photon yields. The importance of rechanneling phenomena in thick crystals is emphasized. The model is then used to calculate the expected X-ray energies, linewidths and brilliance for forthcoming channeling radiation experiments at Fermilab's ASTAmore »photoinjector.« less

  16. Stress-induced changes in gene interactions in human cells

    E-Print Network [OSTI]

    Ives, Zachary G.

    Stress-induced changes in gene interactions in human cells Renuka R. Nayak1 , William E. Bernal2 environments by changing gene expression and gene interactions. To study how human cells response to stress, we endo- plasmic reticulum stress and exposure to ionizing radiation. We identified thousands of genes

  17. Tritium Plasma Experiment and

    Office of Environmental Management (EM)

    23-25, 2014 2 Safety concern: "in-vessel inventory source term" * Challenges in neutron-irradiated plasma facing components (PFCs) - Radiation damages (vacancy,...

  18. Development of Pattern Recognition Software for Tracks of Ionizing Radiation In Medipix2-Based

    E-Print Network [OSTI]

    Vilalta, Ricardo

    , and area monitors to characterize the general background radiation environment harmful to humans needed to support an operational dosimeter that can assess the radiation environment during space with similar Linear Energy Transfers (LETs) for calibration purposes. We describe two modules of our pattern

  19. Packet personal radiation monitor

    DOE Patents [OSTI]

    Phelps, J.E.

    1988-03-31

    A personal radiation monitor of the chirper type is provided for detecting ionizing radiation. A battery powered high voltage power supply is used to generate and apply a high voltage bias to a G-M tube radiation sensor. The high voltage is monitored by a low-loss sensing network which generates a feedback signal to control the high voltage power supply such that the high voltage bias is recharged to +500 VDC when the current pulses of the sensor, generated by the detection of ionizing radiatonevents, discharges the high voltage bias to +450 VDC. During the high voltage recharge period an audio transducer is activated to produce an audible ''chirp''. The rate of the ''chirps'' is controlled by the rate at which the high voltage bias is recharged, which is proportional to the radiation field intensity to which the sensor is exposed. The chirp rate sensitivity is set to be approximately 1.5 (chirps/min/MR/hr.). The G-M tube sensor is used in a current sensing mode so that the device does not paralyze in a high radiation field. 2 figs.

  20. Remote radiation dosimetry

    DOE Patents [OSTI]

    Braunlich, Peter F. (Pullman, WA); Tetzlaff, Wolfgang (Pullman, WA); Hegland, Joel E. (Pullman, WA); Jones, Scott C. (Pullman, WA)

    1991-01-01

    Disclosed are methods and apparatus for remotely measuring radiation levels. Such are particularly useful for measuring relatively high levels or dosages of radiation being administered in radiation therapy. They are also useful for more general radiation level measurements where remote sensing from the remaining portions of the apparatus is desirable. The apparatus uses a beam generator, such as a laser beam, to provide a stimulating beam. The stimulating beam is preferably of wavelengths shorter than 6 microns, or more advantageously less than 2 microns. The stimulating beam is used to stimulate a remote luminescent sensor mounted in a probe which emits stored luminescent energy resulting from exposure of the sensor to ionizing radiation. The stimulating beam is communicated to the remote luminescent sensor via transmissive fiber which also preferably serves to return the emission from the luminescent sensor. The stimulating beam is advantageously split by a beam splitter to create a detector beam which is measured for power during a reading period during which the luminescent phosphor is read. The detected power is preferably used to control the beam generator to thus produce desired beam power during the reading period. The luminescent emission from the remote sensor is communicated to a suitable emission detector, preferably after filtering or other selective treatment to better isolate the luminescent emission.

  1. Remote radiation dosimetry

    DOE Patents [OSTI]

    Braunlich, P.F.; Tetzlaff, W.; Hegland, J.E.; Jones, S.C.

    1991-03-12

    Disclosed are methods and apparatus for remotely measuring radiation levels. Such are particularly useful for measuring relatively high levels or dosages of radiation being administered in radiation therapy. They are also useful for more general radiation level measurements where remote sensing from the remaining portions of the apparatus is desirable. The apparatus uses a beam generator, such as a laser beam, to provide a stimulating beam. The stimulating beam is preferably of wavelengths shorter than 6 microns, or more advantageously less than 2 microns. The stimulating beam is used to stimulate a remote luminescent sensor mounted in a probe which emits stored luminescent energy resulting from exposure of the sensor to ionizing radiation. The stimulating beam is communicated to the remote luminescent sensor via a transmissive fiber which also preferably serves to return the emission from the luminescent sensor. The stimulating beam is advantageously split by a beam splitter to create a detector beam which is measured for power during a reading period during which the luminescent phosphor is read. The detected power is preferably used to control the beam generator to thus produce desired beam power during the reading period. The luminescent emission from the remote sensor is communicated to a suitable emission detector, preferably after filtering or other selective treatment to better isolate the luminescent emission. 8 figures.

  2. NASA/TM--2005213688 Revolutionary Concepts of Radiation

    E-Print Network [OSTI]

    Rathbun, Julie A.

    NASA/TM--2005­213688 Revolutionary Concepts of Radiation Shielding for Human Exploration of Space J, Alabama R.M. Winglee University of Washington, Seattle, Washington March 2005 #12;The NASA STI Program Office...in Profile Since its founding, NASA has been dedicated to the advancement of aeronautics

  3. A new method for solving radiative heat problems in glass

    E-Print Network [OSTI]

    Eindhoven, Technische Universiteit

    RANA 99­06 A new method for solving radiative heat problems in glass B.J. van der Linden --- R, The Netherlands e­mail: linden@win.tue.nl 15th May 2000 #12; Abstract In the production of glass, temperature Conclusion 25 2 #12; Chapter 1 Introduction The production of glass belongs to the oldest forms of human

  4. A new method for solving radiative heat problems in glass

    E-Print Network [OSTI]

    Eindhoven, Technische Universiteit

    RANA 99-06 A new method for solving radiative heat problems in glass B.J. van der Linden -- R, The Netherlands e-mail: linden@win.tue.nl 15th May 2000 #12;Abstract In the production of glass, temperature plays Conclusion 25 2 #12;Chapter 1 Introduction The production of glass belongs to the oldest forms of human

  5. Radiative effects by high-z UV radiation background: Implications for the future CMB polarization measurements

    E-Print Network [OSTI]

    L. A. Popa; C. Burigana; N. Mandolesi

    2005-06-20

    We investigate the role of the radiative effects for the temporal evolution of the reionization fraction by using cosmological Smooth Particle Hydrodynamics (SPH) simulations. We find that the increase of photo-ionization and photo-heating rates due to optical depth effects results in a significantly contribute to the heating of the IGM before and during the reionization. The main effect of the UV radiation spectrum on the temporal evolution of the ionization fraction is given by the value of the reionization redshift and the redshift interval, in which the reionization is completed. We evaluate the effects of the UV radiation background on the CMB angular power spectrum taking into account different temporal evolutions of the ionization fraction. We show that through E-mode CMB polarization power spectrum measurements, the Planck experiment will have the sensitivity to distinguish between different reionization histories even when they imply the same optical depth to electron scattering and degenerated temperature anisotropy power spectra.

  6. Mechanisms of radiation interaction with DNA: Potential implications for radiation protection

    SciTech Connect (OSTI)

    Not Available

    1988-01-01

    The Office of Health and Environmental Research (OHER) of the US Department of Energy conducts a broad multidisciplinary research program which includes basic biophysics, biophysical chemistry, molecular and cellular biology as well as experimental animal studies and opportunistic human studies. This research is directed at understanding how low levels of radiation of various qualities produce the spectrum of biological effects that are seen for such exposures. This workshop was entitled ''Mechanisms of Radiation Interaction with DNA: Potential Implications for Radiation Protection.'' It ws jointly sponsored by the Department of Energy and the Commission of European Communities. The aim of the workshop was to review the base of knowledge in the area of mechanisms of radiation action at the DNA level, and to explore ways in which this information can be applied to the development of scientifically sound concepts and procedures for use in the field of radiation protection. The overview of research provided by this multidisciplinary group will be helpful to the Office in program planning. This report includes a summary of the presentations, extended abstracts, the meeting agenda, research recommendations, and a list of participants. Individual papers are processed separately for the data base.

  7. Trichodermin induces cell apoptosis through mitochondrial dysfunction and endoplasmic reticulum stress in human chondrosarcoma cells

    SciTech Connect (OSTI)

    Su, Chen-Ming; Wang, Shih-Wei; Lee, Tzong-Huei; Tzeng, Wen-Pei; Hsiao, Che-Jen; Liu, Shih-Chia; Tang, Chih-Hsin

    2013-10-15

    Chondrosarcoma is the second most common primary bone tumor, and it responds poorly to both chemotherapy and radiation treatment. Nalanthamala psidii was described originally as Myxosporium in 1926. This is the first study to investigate the anti-tumor activity of trichodermin (trichothec-9-en-4-ol, 12,13-epoxy-, acetate), an endophytic fungal metabolite from N. psidii against human chondrosarcoma cells. We demonstrated that trichodermin induced cell apoptosis in human chondrosarcoma cell lines (JJ012 and SW1353 cells) instead of primary chondrocytes. In addition, trichodermin triggered endoplasmic reticulum (ER) stress protein levels of IRE1, p-PERK, GRP78, and GRP94, which were characterized by changes in cytosolic calcium levels. Furthermore, trichodermin induced the upregulation of Bax and Bid, the downregulation of Bcl-2, and the dysfunction of mitochondria, which released cytochrome c and activated caspase-3 in human chondrosarcoma. In addition, animal experiments illustrated reduced tumor volume, which led to an increased number of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells and an increased level of cleaved PARP protein following trichodermin treatment. Together, this study demonstrates that trichodermin is a novel anti-tumor agent against human chondrosarcoma cells both in vitro and in vivo via mitochondrial dysfunction and ER stress. - Highlights: • Trichodermin induces chondrosarcoma apoptosis. • ER stress is involved in trichodermin-induced cell death. • Trichodermin induces chondrosarcoma death in vivo.

  8. Cognitive Science Q270, section 11246 Experiments and Models in Cognition

    E-Print Network [OSTI]

    Indiana University

    report. The project should either involve experimenting on human subjects or the formal modeling of human 11246 Experiments and Models in Cognition Fall 2009 Tu, Th 2:30-3:45, Room 228 Psychology Bldg project: 15% Lab 2 Apparent motion experiment & computational simulation: 11% Lab 3 Word perception

  9. Composition for radiation shielding

    DOE Patents [OSTI]

    Kronberg, J.W.

    1994-08-02

    A composition for use as a radiation shield is disclosed. The shield has a depleted uranium core for absorbing gamma rays and a bismuth coating for preventing chemical corrosion and absorbing gamma rays. Alternatively, a sheet of gadolinium may be positioned between the uranium core and the bismuth coating for absorbing neutrons. The composition is preferably in the form of a container for storing materials that emit radiation such as gamma rays and neutrons. The container is preferably formed by casting bismuth around a pre-formed uranium container having a gadolinium sheeting, and allowing the bismuth to cool. The resulting container is a structurally sound, corrosion-resistant, radiation-absorbing container. 2 figs.

  10. Pediatric radiation oncology

    SciTech Connect (OSTI)

    Halperin, E.C.; Kun, L.E.; Constine, L.S.; Tarbell, N.J.

    1989-01-01

    This text covers all aspects of radiation therapy for treatment of pediatric cancer. The book describes the proper use of irradiation in each of the malignancies of childhood, including tumors that are rarely encountered in adult practice. These include acute leukemia; supratentorial brain tumors; tumors of the posterior fossa of the brain and spinal canal; retinoblastoma and optic nerve glioma; neuroblastoma; Hodgkin's disease; malignant lymphoma; Ewing's sarcoma; osteosarcoma; rhabdomyosarcoma; Desmoid tumor; Wilms' tumor; liver and biliary tumors; germ cell and stromal cell tumors of the gonads; endocrine, aerodigestive tract, and breast tumors; Langerhans' cell histiocytosis; and skin cancer and hemangiomas. For each type of malignancy, the authors describe the epidemiology, common presenting signs and symptoms, staging, and proper diagnostic workup. Particular attention is given to the indications for radiation therapy and the planning of a course of radiotherapy, including the optimal radiation dose, field size, and technique.

  11. Semiconductor radiation detector

    DOE Patents [OSTI]

    Bell, Zane W. (Oak Ridge, TN); Burger, Arnold (Knoxville, TN)

    2010-03-30

    A semiconductor detector for ionizing electromagnetic radiation, neutrons, and energetic charged particles. The detecting element is comprised of a compound having the composition I-III-VI.sub.2 or II-IV-V.sub.2 where the "I" component is from column 1A or 1B of the periodic table, the "II" component is from column 2B, the "III" component is from column 3A, the "IV" component is from column 4A, the "V" component is from column 5A, and the "VI" component is from column 6A. The detecting element detects ionizing radiation by generating a signal proportional to the energy deposited in the element, and detects neutrons by virtue of the ionizing radiation emitted by one or more of the constituent materials subsequent to capture. The detector may contain more than one neutron-sensitive component.

  12. Radiative Magnetic Reconnection in Astrophysics

    E-Print Network [OSTI]

    Uzdensky, Dmitri A

    2015-01-01

    I review a new rapidly growing area of high-energy plasma astrophysics --- radiative magnetic reconnection, i.e., a reconnection regime where radiation reaction influences reconnection dynamics, energetics, and nonthermal particle acceleration. This influence be may be manifested via a number of astrophysically important radiative effects, such as radiation-reaction limits on particle acceleration, radiative cooling, radiative resistivity, braking of reconnection outflows by radiation drag, radiation pressure, viscosity, and even pair creation at highest energy densities. Self-consistent inclusion of these effects in magnetic reconnection theory and modeling calls for serious modifications to our overall theoretical approach to the problem. In addition, prompt reconnection-powered radiation often represents our only observational diagnostic tool for studying remote astrophysical systems; this underscores the importance of developing predictive modeling capabilities to connect the underlying physical condition...

  13. ATHENA radiation model

    SciTech Connect (OSTI)

    Shumway, R.W.

    1987-10-01

    The ATHENA computer program has many features that make it desirable to use as a space reactor evaluation tool. One of the missing features was a surface-to-surface thermal radiation model. A model was developed that allows any of the regular ATHENA heat slabs to radiate to any other heat slab. The view factors and surface emissivities must be specified by the user. To verify that the model was properly accounting for radiant energy transfer, two different types of test calculations were performed. Both calculations have excellent results. The updates have been used on both the INEL CDC-176 and the Livermore Cray. 7 refs., 2 figs., 6 tabs.

  14. Wireless passive radiation sensor

    DOE Patents [OSTI]

    Pfeifer, Kent B; Rumpf, Arthur N; Yelton, William G; Limmer, Steven J

    2013-12-03

    A novel measurement technique is employed using surface acoustic wave (SAW) devices, passive RF, and radiation-sensitive films to provide a wireless passive radiation sensor that requires no batteries, outside wiring, or regular maintenance. The sensor is small (<1 cm.sup.2), physically robust, and will operate unattended for decades. In addition, the sensor can be insensitive to measurement position and read distance due to a novel self-referencing technique eliminating the need to measure absolute responses that are dependent on RF transmitter location and power.

  15. Radiation monitor for liquids

    DOE Patents [OSTI]

    Koster, J.E.; Bolton, R.D.

    1999-03-02

    A radiation monitor for use with liquids that utilizes air ions created by alpha radiation emitted by the liquids as its detectable element. A signal plane, held at an electrical potential with respect to ground, collects these air ions. A guard plane or guard rings is used to limit leakage currents. In one embodiment, the monitor is used for monitoring liquids retained in a tank. Other embodiments monitor liquids flowing through a tank, and bodies of liquids, such as ponds, lakes, rivers and oceans. 4 figs.

  16. Radiation monitor for liquids

    DOE Patents [OSTI]

    Koster, James E. (Los Alamos, NM); Bolton, Richard D. (Los Alamos, NM)

    1999-01-01

    A radiation monitor for use with liquids that utilizes air ions created by alpha radiation emitted by the liquids as its detectable element. A signal plane, held at an electrical potential with respect to ground, collects these air ions. A guard plane or guard rings is used to limit leakage currents. In one embodiment, the monitor is used for monitoring liquids retained in a tank. Other embodiments monitor liquids flowing through a tank, and bodies of liquids, such as ponds, lakes, rivers and oceans.

  17. Modeling of laser ablation and fragmentation of human calculi

    SciTech Connect (OSTI)

    Gitomer, S.; Jones, R.D.; Howsare, C.

    1989-01-01

    The large-scale radiation-hydrodynamics computer code LASNEX, has been used to model experimental results in the laser ablation and fragmentation of renal and biliary calculi. Recent experiments have demonstrated laser ablation and fragmentation of human calculi in vitro and in vivo. In the interaction, laser light incident upon the calculus is of sufficient intensity to produce a plasma (a hot ionized gas). The physical picture which emerges is as follows. The plasma couples to acoustic and shear waves which then propagate through the dense stone material, causing spall and fracture by reflection from material discontinuities or boundaries. Experiments have thus far yielded data on the interaction against which models can be tested. Data on the following have been published: (1) light emission, (2) absorption and emission spectra, (3) fragmentation efficiency, (4) cavitation bubble dynamics and (5) mass removal. We have performed one dimensional simulations of the laser-matter interaction to elucidate the important physical mechanisms. We find that good quantitative fits between simulation and experiment are obtained for visible light emission, electron temperature, electron density, plasma pressure and cavitation bubble growth. With regard to mass removal, experiment and simulation are consistent with each other and give an excellent estimate of the ablation threshold. The modeling indicates that a very small ablation layer at the surface of the calculus is responsible for significant mass loss by fragmentation within the bulk of the calculus. With such quantitative fits in hand, we believe this type of modeling can now be applied to the study of other procedures involving plasma formation of interest to the medical community. 25 refs., 7 figs.

  18. Ideal Observers for Detecting Human Motion: Correspondence Noise.

    E-Print Network [OSTI]

    Yuille, Alan L.

    purpose, models of motion. We perform more psychophysical experiments which are consistent with humansIdeal Observers for Detecting Human Motion: Correspondence Noise. HongJing Lo Department obtain Barlow and Tripathy's classic model as an approximation. Our psychophysical experiments show

  19. Low-Dose Radiation Cataract and Genetic Determinants of Radiosensitivity

    SciTech Connect (OSTI)

    Kleiman, Norman Jay

    2013-11-30

    The lens of the eye is one of the most radiosensitive tissues in the body. Ocular ionizing radiation exposure results in characteristic, dose related, progressive lens changes leading to cataract formation. While initial, early stages of lens opacification may not cause visual disability, the severity of such changes progressively increases with dose until vision is impaired and cataract extraction surgery may be required. Because of the transparency of the eye, radiation induced lens changes can easily be followed non-invasively over time. Thus, the lens provides a unique model system in which to study the effects of low dose ionizing radiation exposure in a complex, highly organized tissue. Despite this observation, considerable uncertainties remain surrounding the relationship between dose and risk of developing radiation cataract. For example, a growing number of human epidemiological findings suggest significant risk among various groups of occupationally and accidentally exposed individuals and confidence intervals that include zero dose. Nevertheless, questions remain concerning the relationship between lens opacities, visual disability, clinical cataract, threshold dose and/or the role of genetics in determining radiosensitivity. Experimentally, the response of the rodent eye to radiation is quite similar to that in humans and thus animal studies are well suited to examine the relationship between radiation exposure, genetic determinants of radiosensitivity and cataractogenesis. The current work has expanded our knowledge of the low-dose effects of X-irradiation or high-LET heavy ion exposure on timing and progression of radiation cataract and has provided new information on the genetic, molecular, biochemical and cell biological features which contribute to this pathology. Furthermore, findings have indicated that single and/or multiple haploinsufficiency for various genes involved in DNA repair and cell cycle checkpoint control, such as Atm, Brca1 or Rad9, influence cataract development and thus radiosensitivity. These observations have direct applicability to various human populations including accidentally exposed individuals, interventional medical workers, astronauts and nuclear plant workers.

  20. From HumanFrom Human--Subject Experiments ToSubject Experiments To ComputationalComputational--Agent ExperimentsAgent Experiments

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    ,... - Biological entities: crops, livestock, forests,... - Physical entities: weather, landscape, electric grids TesfatsionLeigh Tesfatsion ISU Prof. of Econ, Math, and Electrical & Computer EngineeringISU Prof. of Econ, Math, and Electrical & Computer Engineering http://www.econ.iastate.edu/tesfatsi/ tesfatsi

  1. Origin of Cosmic Radiation

    E-Print Network [OSTI]

    Thomas K. Gaisser

    2000-11-28

    I give a brief overview of cosmic ray physics, highlighting some key questions and how they will be addressed by new experiments.

  2. Janus Experiments: Data from Mouse Irradiation Experiments 1972 - 1989

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    The Janus Experiments, carried out at Argonne National Laboratory from 1972 to 1989 and supported by grants from the US Department of Energy, investigated the effects of neutron and gamma radiation on mouse tissues primarily from B6CF1 mice. 49,000 mice were irradiated: Death records were recorded for 42,000 mice; gross pathologies were recorded for 39,000 mice; and paraffin embedded tissues were preserved for most mice. Mouse record details type and source of radiation [gamma, neutrons]; dose and dose rate [including life span irradiation]; type and presence/absence of radioprotector treatment; tissue/animal morphology and pathology. Protracted low dose rate treatments, short term higher dose rate treatments, variable dose rates with a same total dose, etc. in some cases in conjunction with radioprotectors, were administered. Normal tissues, tumors, metastases were preserved. Standard tissues saved were : lung, liver, spleen, kidney, heart, any with gross lesions (including mammary glands, Harderian gland with eye, adrenal gland, gut, ovaries or testes, brain and pituitary, bone). Data are searchable and specimens can be obtained by request.

  3. Radiation detector spectrum simulator

    DOE Patents [OSTI]

    Wolf, Michael A. (Los Alamos, NM); Crowell, John M. (Los Alamos, NM)

    1987-01-01

    A small battery operated nuclear spectrum simulator having a noise source nerates pulses with a Gaussian distribution of amplitudes. A switched dc bias circuit cooperating therewith generates several nominal amplitudes of such pulses and a spectral distribution of pulses that closely simulates the spectrum produced by a radiation source such as Americium 241.

  4. Radiation detector spectrum simulator

    DOE Patents [OSTI]

    Wolf, M.A.; Crowell, J.M.

    1985-04-09

    A small battery operated nuclear spectrum simulator having a noise source generates pulses with a Gaussian distribution of amplitudes. A switched dc bias circuit cooperating therewith to generate several nominal amplitudes of such pulses and a spectral distribution of pulses that closely simulates the spectrum produced by a radiation source such as Americium 241.

  5. Radiation Source Replacement Workshop

    SciTech Connect (OSTI)

    Griffin, Jeffrey W.; Moran, Traci L.; Bond, Leonard J.

    2010-12-01

    This report summarizes a Radiation Source Replacement Workshop in Houston Texas on October 27-28, 2010, which provided a forum for industry and researchers to exchange information and to discuss the issues relating to replacement of AmBe, and potentially other isotope sources used in well logging.

  6. Thermal radiation Ron Zevenhoven

    E-Print Network [OSTI]

    Zevenhoven, Ron

    .00032, similarly for 2·T = 0.7·2500 = 1750 µmK4 this gives f0-2 = 0.03392. Thus for 0.4 - 0.7 µm, f1-2 = 0Thermal radiation revisited Ron Zevenhoven Ĺbo Akademi University Thermal and Flow Engineering Laboratory / Värme- och strömningsteknik tel. 3223 ; ron.zevenhoven@abo.fi Process Engineering

  7. Three Dimensional Radiative Transfer

    E-Print Network [OSTI]

    Tom Abel

    2000-05-09

    Radiative Transfer (RT) effects play a crucial role in the thermal history of the intergalactic medium. Here I discuss recent advances in the development of numerical methods that introduce RT to cosmological hydrodynamics. These methods can also readily be applied to time dependent problems on interstellar and galactic scales.

  8. Thermostatic Radiator Valve Evaluation

    SciTech Connect (OSTI)

    Dentz, Jordan; Ansanelli, Eric

    2015-01-01

    A large stock of multifamily buildings in the Northeast and Midwest are heated by steam distribution systems. Losses from these systems are typically high and a significant number of apartments are overheated much of the time. Thermostatically controlled radiator valves (TRVs) are one potential strategy to combat this problem, but have not been widely accepted by the residential retrofit market.

  9. Local microwave background radiation

    E-Print Network [OSTI]

    Domingos Soares

    2014-11-13

    An inquiry on a possible local origin for the Microwave Background Radiation is made. Thermal MBR photons are contained in a system called {\\it magnetic bottle} which is due to Earth magnetic field and solar wind particles, mostly electrons. Observational tests are anticipated.

  10. West Virginia University 1 College of Education and Human Services

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    West Virginia University 1 College of Education and Human Services Degrees Offered · Bachelor The College of Education and Human Services is divided into five academic departments: Counseling experiences in a professional development school. The College of Education and Human Services cooperates

  11. Coherence properties of the radiation from FLASH

    E-Print Network [OSTI]

    Schneidmiller, E A

    2015-01-01

    FLASH is the first free electron laser user facility operating in the vacuum ultraviolet and soft x-ray wavelength range. Many user experiments require knowledge of the spatial and temporal coherence properties of the radiation. In this paper we present an analysis of the coherence properties of the radiation for the fundamental and for the higher odd frequency harmonics. We show that temporal and spatial coherence reach maximum close to the FEL saturation but may degrade significantly in the post-saturation regime. We also find that the pointing stability of short FEL pulses is limited due to the fact that non-azimuthal FEL eigenmodes are not sufficiently suppressed. We discuss possible ways for improving the degree of transverse coherence and the pointing stability.

  12. Simulation of radiation-induced defects

    E-Print Network [OSTI]

    Peltola, Timo

    2015-01-01

    Mainly due to their outstanding performance the position sensitive silicon detectors are widely used in the tracking systems of High Energy Physics experiments such as the ALICE, ATLAS, CMS and LHCb at LHC, the world's largest particle physics accelerator at CERN, Geneva. The foreseen upgrade of the LHC to its high luminosity (HL) phase (HL-LHC scheduled for 2023), will enable the use of maximal physics potential of the facility. After 10 years of operation the expected fluence will expose the tracking systems at HL-LHC to a radiation environment that is beyond the capacity of the present system design. Thus, for the required upgrade of the all-silicon central trackers extensive measurements and simulation studies for silicon sensors of different designs and materials with sufficient radiation tolerance have been initiated within the RD50 Collaboration. Supplementing measurements, simulations are in vital role for e.g. device structure optimization or predicting the electric fields and trapping in the silicon...

  13. Minibeam radiation therapy for the management of osteosarcomas: A Monte Carlo study

    SciTech Connect (OSTI)

    Martínez-Rovira, I.; Prezado, Y.

    2014-06-15

    Purpose: Minibeam radiation therapy (MBRT) exploits the well-established tissue-sparing effect provided by the combination of submillimetric field sizes and a spatial fractionation of the dose. The aim of this work is to evaluate the feasibility and potential therapeutic gain of MBRT, in comparison with conventional radiotherapy, for osteosarcoma treatments. Methods: Monte Carlo simulations (PENELOPE/PENEASY code) were used as a method to study the dose distributions resulting from MBRT irradiations of a rat femur and a realistic human femur phantoms. As a figure of merit, peak and valley doses and peak-to-valley dose ratios (PVDR) were assessed. Conversion of absorbed dose to normalized total dose (NTD) was performed in the human case. Several field sizes and irradiation geometries were evaluated. Results: It is feasible to deliver a uniform dose distribution in the target while the healthy tissue benefits from a spatial fractionation of the dose. Very high PVDR values (?20) were achieved in the entrance beam path in the rat case. PVDR values ranged from 2 to 9 in the human phantom. NTD{sub 2.0} of 87 Gy might be reached in the tumor in the human femur while the healthy tissues might receive valley NTD{sub 2.0} lower than 20 Gy. The doses in the tumor and healthy tissues might be significantly higher and lower than the ones commonly delivered used in conventional radiotherapy. Conclusions: The obtained dose distributions indicate that a gain in normal tissue sparing might be expected. This would allow the use of higher (and potentially curative) doses in the tumor. Biological experiments are warranted.

  14. Radiation Chemistry Radiation causes changes in molecules by both

    E-Print Network [OSTI]

    Massey, Thomas N.

    Module 4 Radiation Chemistry · Radiation causes changes in molecules by both direct and indirect radiation on the target molecules · Indirect Action - energy transported by chemical species to cause damage or Pyrimidene. · Loss of Purine or Pyrimidine · Free radical transfer causing the loss of base and chain

  15. Radiation Safety Manual March 21, 2015 RADIATION SAFETY

    E-Print Network [OSTI]

    Lance, Veronica P.

    . Radioactive Drug Research Committee D. Radiation Safety Officers E. Authorized Users Chapter II: Radiation. Clinical Applications C. Loans and Transfers of Radioactive Materials Chapter VI: Occupational Exposure of Packages Containing Radioactive Materials A. Packages Delivered to the Radiation Safety Office B. Packages

  16. Radiation Safety Training Basic Radiation Safety Training for

    E-Print Network [OSTI]

    Dai, Pengcheng

    Radiation Safety Training Basic Radiation Safety Training for Sealed Source Users for Physics 461 Protocol Title: Training for Sealed Source Users Drafted By: Chris Millsaps, RSS Reviewers: ZB, TU, GS Purpose: To provide basic radiation safety training to the users of sealed sources located

  17. Degradation of silicon ac-coupled microstrip detectors induced by radiation

    SciTech Connect (OSTI)

    Bacchetta, N.; Gotra, Yu.; Bisello, D.; Canali, C.; Fuochi, P.G.; Paccagnella, A.; Verzellesi, G.

    1993-12-01

    Results are presented showing the radiation response of ac-coupled FOXFET biased microstrip detectors and related test patterns to be used in the microvertex detector of the CDF experiment at Fermi National Laboratory. Radiation tolerance of detectors to gamma and proton irradiation has been tested and the radiation induced variations of the dc electrical parameters have been analyzed. Long term post-irradiation behavior of detector characteristics have been studied, and the relevant room temperature annealing phenomena have been discussed.

  18. MCNP benchmark analyses of critical experiments for the Space Nuclear Thermal Propulsion program

    SciTech Connect (OSTI)

    Selcow, E.C.; Cerbone, R.J.; Ludewig, H.; Mughabghab, S.F.; Schmidt, E.; Todosow, M. [Brookhaven National Lab., Upton, NY (United States); Parma, E.J. [Sandia National Labs., Albuquerque, NM (United States); Ball, R.M.; Hoovler, G.S. [Babcock and Wilcox Co., Lynchburg, VA (United States)

    1993-06-01

    Benchmark analyses have been performed of Particle Bed Reactor (PBR) critical experiments (CX) using the MCNP radiation transport code. The experiments have been conducted at the Sandia National Laboratory reactor facility in support of the Space Nuclear Thermal Propulsion (SNTP) program. The test reactor is a nineteen element water moderated and reflected thermal system. A series of integral experiments have been carried out to test the capabilities of the radiation transport codes to predict the performance of PBR systems. MCNP was selected as the preferred radiation analysis tool for the benchmark experiments. Comparison between experimental and calculational results indicate very good agreement. This paper describes the analyses of benchmark experiments designed to quantify the accuracy of the MCNP radiation transport code for predicting the performance characteristics of PBR reactors.

  19. RADIATION DAMAGE OF GERMANIUM DETECTORS

    E-Print Network [OSTI]

    Pehl, Richard H.

    2011-01-01

    the high-energy proton damage than was the planar detector.as far as radiation damage is concerned. Unfortunately, some28-29, 1978 LBL-7967 RADIATION DAMAGE OF GERMANIUM DETECTORS

  20. TIME DOMAIN SIMULATIONS OF RADIATION

    E-Print Network [OSTI]

    ;Introduction Fan Noise Forward Radiation Fan Noise Aft Radiation Jet Noise (separate LES Code)Traditional CFD a 16-processor machine yourself : 8 dual-processor workstations 800 MHz Pentium III processors 1 GB RAM

  1. Annual Report: Hydrodynamics and Radiative Hydrodynamics with Astrophysical Applications

    SciTech Connect (OSTI)

    R. Paul Drake

    2005-12-01

    We report the ongoing work of our group in hydrodynamics and radiative hydrodynamics with astrophysical applications. During the period of the existing grant, we have carried out two types of experiments at the Omega laser. One set of experiments has studied radiatively collapsing shocks, obtaining high-quality scaling data using a backlit pinhole and obtaining the first (ever, anywhere) Thomson-scattering data from a radiative shock. Other experiments have studied the deeply nonlinear development of the Rayleigh-Taylor (RT) instability from complex initial conditions, obtaining the first (ever, anywhere) dual-axis radiographic data using backlit pinholes and ungated detectors. All these experiments have applications to astrophysics, discussed in the corresponding papers either in print or in preparation. We also have obtained preliminary radiographs of experimental targets using our x-ray source. The targets for the experiments have been assembled at Michigan, where we also prepare many of the simple components. The above activities, in addition to a variety of data analysis and design projects, provide good experience for graduate and undergraduates students. In the process of doing this research we have built a research group that uses such work to train junior scientists.

  2. Functional genomics as a window on radiation stress signaling Sally A Amundson*,1

    E-Print Network [OSTI]

    Functional genomics as a window on radiation stress signaling Sally A Amundson*,1 , Michael Bittner 20892, USA; 2 National Human Genome Research Institute, National Institutes of Health, Bethesda, MD before the completion of the human genome draft sequence, a number of techniques for genomic expression

  3. DOE Radiation Records Contacts List

    Broader source: Energy.gov [DOE]

    DOE radiation records contact list for individuals to obtain records of occupational exposure directly from a DOE site.

  4. Gamma radiation field intensity meter

    DOE Patents [OSTI]

    Thacker, L.H.

    1995-10-17

    A gamma radiation intensity meter measures dose rate of a radiation field. The gamma radiation intensity meter includes a tritium battery emitting beta rays generating a current which is essentially constant. Dose rate is correlated to an amount of movement of an electroscope element charged by the tritium battery. Ionizing radiation decreases the voltage at the element and causes movement. A bleed resistor is coupled between the electroscope support element or electrode and the ionization chamber wall electrode. 4 figs.

  5. Gamma radiation field intensity meter

    DOE Patents [OSTI]

    Thacker, L.H.

    1994-08-16

    A gamma radiation intensity meter measures dose rate of a radiation field. The gamma radiation intensity meter includes a tritium battery emitting beta rays generating a current which is essentially constant. Dose rate is correlated to an amount of movement of an electroscope element charged by the tritium battery. Ionizing radiation decreases the voltage at the element and causes movement. A bleed resistor is coupled between the electroscope support element or electrode and the ionization chamber wall electrode. 4 figs.

  6. Gamma radiation field intensity meter

    DOE Patents [OSTI]

    Thacker, Louis H. (Knoxville, TN)

    1995-01-01

    A gamma radiation intensity meter measures dose rate of a radiation field. The gamma radiation intensity meter includes a tritium battery emitting beta rays generating a current which is essentially constant. Dose rate is correlated to an amount of movement of an electroscope element charged by the tritium battery. Ionizing radiation decreases the voltage at the element and causes movement. A bleed resistor is coupled between the electroscope support element or electrode and the ionization chamber wall electrode.

  7. Gamma radiation field intensity meter

    DOE Patents [OSTI]

    Thacker, Louis H. (Knoxville, TN)

    1994-01-01

    A gamma radiation intensity meter measures dose rate of a radiation field. The gamma radiation intensity meter includes a tritium battery emitting beta rays generating a current which is essentially constant. Dose rate is correlated to an amount of movement of an electroscope element charged by the tritium battery. Ionizing radiation decreases the voltage at the element and causes movement. A bleed resistor is coupled between the electroscope support element or electrode and the ionization chamber wall electrode.

  8. COLUMBIA UNIVERSITY Radiation Safety Program

    E-Print Network [OSTI]

    Jia, Songtao

    and will be maintained in a separate file from personnel radiation dosimeter records. All workers are specifically

  9. Interpreting the unresolved intensity of cosmologically redshifted line radiation

    E-Print Network [OSTI]

    Switzer, Eric R; Masui, Kiyoshi W; Pen, Ue-Li; Voytek, Tabitha C

    2015-01-01

    Intensity mapping experiments survey the spectrum of diffuse line radiation rather than detect individual objects at high signal-to-noise. Spectral maps of unresolved atomic and molecular line radiation contain three-dimensional information about the density and environments of emitting gas, and efficiently probe cosmological volumes out to high redshift. Intensity mapping survey volumes also contain all other sources of radiation at the frequencies of interest. Continuum foregrounds are typically ~10^2-10^3 times brighter than the cosmological signal. The instrumental response to bright foregrounds will produce new spectral degrees of freedom that are not known in advance, nor necessarily spectrally smooth. The intrinsic spectra of foregrounds may also not be well-known in advance. We describe a general class of quadratic estimators to analyze data from single-dish intensity mapping experiments, and determine contaminated spectral modes from the data itself. The key attribute of foregrounds is not that they ...

  10. Early test facilities and analytic methods for radiation shielding: Proceedings

    SciTech Connect (OSTI)

    Ingersoll, D.T. ); Ingersoll, J.K. )

    1992-11-01

    This report represents a compilation of eight papers presented at the 1992 American Nuclear Society/European Nuclear Society International Meeting. The meeting is of special significance since it commemorates the fiftieth anniversary of the first controlled nuclear chain reaction. The papers contained in this report were presented in a special session organized by the Radiation Protection and Shielding Division in keeping with the historical theme of the meeting. The paper titles are good indicators of their content and are: (1) The origin of radiation shielding research: The Oak Ridge experience, (2) Shielding research at the hanford site, (3) Aircraft shielding experiments at General Dynamics Fort Worth, 1950-1962, (4) Where have the neutrons gone , a history of the tower shielding facility, (5) History and evolution of buildup factors, (6) Early shielding research at Bettis atomic power laboratory, (7) UK reactor shielding: then and now, (8) A very personal view of the development of radiation shielding theory.

  11. Health Impacts from Acute Radiation Exposure

    SciTech Connect (OSTI)

    Strom, Daniel J.

    2003-09-30

    Absorbed doses above1-2 Gy (100-200 rads) received over a period of a day or less lead to one or another of the acute radiation syndromes. These are the hematopoietic syndrome, the gastrointestinal (GI) syndrome, the cerebrovascular (CV) syndrome, the pulmonary syndrome, or the cutaneous syndrome. The dose that will kill about 50% of the exposed people within 60 days with minimal medical care, LD50-60, is around 4.5 Gy (450 rads) of low-LET radiation measured free in air. The GI syndrome may not be fatal with supportive medical care and growth factors below about 10 Gy (1000 rads), but above this is likely to be fatal. Pulmonary and cutaneous syndromes may or may not be fatal, depending on many factors. The CV syndrome is invariably fatal. Lower acute doses, or protracted doses delivered over days or weeks, may lead to many other health outcomes than death. These include loss of pregnancy, cataract, impaired fertility or temporary or permanent sterility, hair loss, skin ulceration, local tissue necrosis, developmental abnormalities including mental and growth retardation in persons irradiated as children or fetuses, radiation dermatitis, and other symptoms listed in Table 2 on page 12. Children of parents irradiated prior to conception may experience heritable ill-health, that is, genetic changes from their parents. These effects are less strongly expressed than previously thought. Populations irradiated to high doses at high dose rates have increased risk of cancer incidence and mortality, taken as about 10-20% incidence and perhaps 5-10% mortality per sievert of effective dose of any radiation or per gray of whole-body absorbed dose low-LET radiation. Cancer risks for non-uniform irradiation will be less.

  12. Working With Radiation For Research

    E-Print Network [OSTI]

    Jia, Songtao

    flight New York to LA 5 Moving from east coast to Denver for one year 50 Moving from frame house to brick with an ever-present background of radiation. Radiation & Life 1* *2 #12;3 · Radiation is energy traveling with sufficiently energy to remove electrons from the atoms or molecules of the substances it passes through. Can

  13. THE DEMONSTRATION AND SCIENCE EXPERIMENTS (DSX): A FUNDAMENTAL SCIENCE RESEARCH MISSION ADVANCING TECHNOLOGIES

    E-Print Network [OSTI]

    Strangeway, Robert J.

    based research areas are: · Wave Particle Interaction Experiment: Researching the physics of very low experiments include research in three major experiment categories. The physics of Very Low Frequency (VLF, 0 distributions; radiation dose rates, local magnetic fields and pitch angle distributions in the poorly

  14. Human Subjects Section 6. Protection of Human

    E-Print Network [OSTI]

    Heller, Barbara

    Human Subjects Section 6. Protection of Human Subjects This section is required for applicants answering "yes" to the question "Are human subjects involved?" on the R&R Other Project Information form subjects applicants must provide a justification in this section for the claim that no human subjects

  15. Apparatuses for large area radiation detection and related method

    DOE Patents [OSTI]

    Akers, Douglas W; Drigert, Mark W

    2015-04-28

    Apparatuses and a related method relating to radiation detection are disclosed. In one embodiment, an apparatus includes a first scintillator and a second scintillator adjacent to the first scintillator, with each of the first scintillator and second scintillator being structured to generate a light pulse responsive to interacting with incident radiation. The first scintillator is further structured to experience full energy deposition of a first low-energy radiation, and permit a second higher-energy radiation to pass therethrough and interact with the second scintillator. The apparatus further includes a plurality of light-to-electrical converters operably coupled to the second scintillator and configured to convert light pulses generated by the first scintillator and the second scintillator into electrical signals. The first scintillator and the second scintillator exhibit at least one mutually different characteristic for an electronic system to determine whether a given light pulse is generated by the first scintillator or the second scintillator.

  16. Compton Scattered Transition Radiation from Very High Energy Particles

    E-Print Network [OSTI]

    M. L. Cherry; G. L. Case

    2002-06-04

    X-ray transition radiation can be used to measure the Lorentz factor of relativistic particles. At energies approaching gamma = E/mc^2 = 10^5, transition radiation detectors (TRDs) can be optimized by using thick (sim 5 - 10 mil) foils with large (5-10 mm) spacings. This implies X-ray energies >100 keV and the use of scintillators as the X-ray detectors. Compton scattering of the X-rays out of the particle beam then becomes an important effect. We discuss the design of very high energy detectors, the use of metal radiator foils rather than the standard plastic foils, inorganic scintillators for detecting Compton scattered transition radiation, and the application to the ACCESS cosmic ray experiment.

  17. rev December 2010 Radiation Safety Manual Section 9 Radiation Protection Procedures

    E-Print Network [OSTI]

    Sniadecki, Nathan J.

    rev December 2010 Radiation Safety Manual Section 9 ­ Radiation Protection Procedures Page 9-1 Section 9 Radiation Protection Procedures Contents Section 9 9-1 Radiation Protection Procedures Protective Measures - External Radiation.....................................9-5 1. Time

  18. DOE 2008 Occupational Radiation Exposure October 2009

    SciTech Connect (OSTI)

    U.S. Department of Energy, Office of Health, Safety and Security

    2009-10-01

    A major priority of the U.S. Department of Energy (DOE) is to ensure the health, safety, and security of DOE employees, contractors, and subcontractors. The Office of Health, Safety and Security (HSS) provides the corporate-level leadership and strategic vision necessary to better coordinate and integrate health, safety, environment, security, enforcement, and independent oversight programs. One function that supports this mission is the DOE Corporate Operating Experience Program that provides collection, analysis, and dissemination of performance indicators, such as occupational radiation exposure information. This analysis supports corporate decision-making and synthesizes operational information to support continuous environment, safety, and health improvement across the DOE complex.

  19. Radiation Chemistry of Advanced TALSPEAK Flowsheet

    SciTech Connect (OSTI)

    Mincher, Bruce; Peterman, Dean; Mcdowell, Rocklan; Olson, Lonnie; Lumetta, Gregg J.

    2013-08-28

    This report summarizes the results of initial experiments designed to understand the radiation chemistry of an Advanced TALSPEAK process for separating trivalent lanthanides form the actinides. Biphasic aerated samples were irradiated and then analyzed for post-irradiation constituent concentrations and solvent extraction distribution ratios. The effects of irradiation on the TALSPEAK and Advanced TALSPEAK solvents were similar, with very little degradation of the organic phase extractant. Decomposition products were detected, with a major product in common for both solvents. This product may be responsible for the slight increase in distribution ratios for Eu and Am with absorbed dose, however; separation factors were not greatly affected.

  20. Multilayer radiation shield

    DOE Patents [OSTI]

    Urbahn, John Arthur (Saratoga Springs, NY); Laskaris, Evangelos Trifon (Niskayuna, NY)

    2009-06-16

    A power generation system including: a generator including a rotor including a superconductive rotor coil coupled to a rotatable shaft; a first prime mover drivingly coupled to the rotatable shaft; and a thermal radiation shield, partially surrounding the rotor coil, including at least a first sheet and a second sheet spaced apart from the first sheet by centripetal force produced by the rotatable shaft. A thermal radiation shield for a generator including a rotor including a super-conductive rotor coil including: a first sheet having at least one surface formed from a low emissivity material; and at least one additional sheet having at least one surface formed from a low emissivity material spaced apart from the first sheet by centripetal force produced by the rotatable shaft, wherein each successive sheet is an incrementally greater circumferential arc length and wherein the centripetal force shapes the sheets into a substantially catenary shape.

  1. Handheld CZT radiation detector

    DOE Patents [OSTI]

    Murray, William S.; Butterfield, Kenneth B.; Baird, William

    2004-08-24

    A handheld CZT radiation detector having a CZT gamma-ray sensor, a multichannel analyzer, a fuzzy-logic component, and a display component is disclosed. The CZT gamma-ray sensor may be a coplanar grid CZT gamma-ray sensor, which provides high-quality gamma-ray analysis at a wide range of operating temperatures. The multichannel analyzer categorizes pulses produce by the CZT gamma-ray sensor into channels (discrete energy levels), resulting in pulse height data. The fuzzy-logic component analyzes the pulse height data and produces a ranked listing of radioisotopes. The fuzzy-logic component is flexible and well-suited to in-field analysis of radioisotopes. The display component may be a personal data assistant, which provides a user-friendly method of interacting with the detector. In addition, the radiation detector may be equipped with a neutron sensor to provide an enhanced mechanism of sensing radioactive materials.

  2. Semiconductor radiation detector

    DOE Patents [OSTI]

    Patt, Bradley E. (Sherman Oaks, CA); Iwanczyk, Jan S. (Los Angeles, CA); Tull, Carolyn R. (Orinda, CA); Vilkelis, Gintas (Westlake Village, CA)

    2002-01-01

    A semiconductor radiation detector is provided to detect x-ray and light photons. The entrance electrode is segmented by using variable doping concentrations. Further, the entrance electrode is physically segmented by inserting n+ regions between p+ regions. The p+ regions and the n+ regions are individually biased. The detector elements can be used in an array, and the p+ regions and the n+ regions can be biased by applying potential at a single point. The back side of the semiconductor radiation detector has an n+ anode for collecting created charges and a number of p+ cathodes. Biased n+ inserts can be placed between the p+ cathodes, and an internal resistor divider can be used to bias the n+ inserts as well as the p+ cathodes. A polysilicon spiral guard can be implemented surrounding the active area of the entrance electrode or surrounding an array of entrance electrodes.

  3. General Relativistic Radiative Transfer

    E-Print Network [OSTI]

    S. Knop; P. H. Hauschildt; E. Baron

    2006-11-30

    We present a general method to calculate radiative transfer including scattering in the continuum as well as in lines in spherically symmetric systems that are influenced by the effects of general relativity (GR). We utilize a comoving wavelength ansatz that allows to resolve spectral lines throughout the atmosphere. The used numerical solution is an operator splitting (OS) technique that uses a characteristic formal solution. The bending of photon paths and the wavelength shifts due to the effects of GR are fully taken into account, as is the treatment of image generation in a curved spacetime. We describe the algorithm we use and demonstrate the effects of GR on the radiative transport of a two level atom line in a neutron star like atmosphere for various combinations of continuous and line scattering coefficients. In addition, we present grey continuum models and discuss the effects of different scattering albedos on the emergent spectra and the determination of effective temperatures and radii of neutron star atmospheres.

  4. Radiation shielding composition

    DOE Patents [OSTI]

    Quapp, William J. (Idaho Falls, ID); Lessing, Paul A. (Idaho Falls, ID)

    2000-12-26

    A composition for use as a radiation shield. The shield is a concrete product containing a stable uranium aggregate for attenuating gamma rays and a neutron absorbing component, the uranium aggregate and neutron absorbing component being present in the concrete product in sufficient amounts to provide a concrete having a density between about 4 and about 15 grams/cm.sup.3 and which will at a predetermined thickness, attenuate gamma rays and absorb neutrons from a radioactive material of projected gamma ray and neutron emissions over a determined time period. The composition is preferably in the form of a container for storing radioactive materials that emit gamma rays and neutrons. The concrete container preferably comprises a metal liner and/or a metal outer shell. The resulting radiation shielding container has the potential of being structurally sound, stable over a long period of time, and, if desired, readily mobile.

  5. Radiation shielding composition

    DOE Patents [OSTI]

    Quapp, William J. (Idaho Falls, ID); Lessing, Paul A. (Idaho Falls, ID)

    1998-01-01

    A composition for use as a radiation shield. The shield is a concrete product containing a stable uranium aggregate for attenuating gamma rays and a neutron absorbing component, the uranium aggregate and neutron absorbing component being present in the concrete product in sufficient amounts to provide a concrete having a density between about 4 and about 15 grams/cm.sup.3 and which will at a predetermined thickness, attenuate gamma rays and absorb neutrons from a radioactive material of projected gamma ray and neutron emissions over a determined time period. The composition is preferably in the form of a container for storing radioactive materials that emit gamma rays and neutrons. The concrete container preferably comprises a metal liner and/or a metal outer shell. The resulting radiation shielding container has the potential of being structurally sound, stable over a long period of time, and, if desired, readily mobile.

  6. Time encoded radiation imaging

    DOE Patents [OSTI]

    Marleau, Peter; Brubaker, Erik; Kiff, Scott

    2014-10-21

    The various technologies presented herein relate to detecting nuclear material at a large stand-off distance. An imaging system is presented which can detect nuclear material by utilizing time encoded imaging relating to maximum and minimum radiation particle counts rates. The imaging system is integrated with a data acquisition system that can utilize variations in photon pulse shape to discriminate between neutron and gamma-ray interactions. Modulation in the detected neutron count rates as a function of the angular orientation of the detector due to attenuation of neighboring detectors is utilized to reconstruct the neutron source distribution over 360 degrees around the imaging system. Neutrons (e.g., fast neutrons) and/or gamma-rays are incident upon scintillation material in the imager, the photons generated by the scintillation material are converted to electrical energy from which the respective neutrons/gamma rays can be determined and, accordingly, a direction to, and the location of, a radiation source identified.

  7. Radiation shielding composition

    DOE Patents [OSTI]

    Quapp, W.J.; Lessing, P.A.

    1998-07-28

    A composition is disclosed for use as a radiation shield. The shield is a concrete product containing a stable uranium aggregate for attenuating gamma rays and a neutron absorbing component, the uranium aggregate and neutron absorbing component being present in the concrete product in sufficient amounts to provide a concrete having a density between about 4 and about 15 grams/cm{sup 3} and which will at a predetermined thickness, attenuate gamma rays and absorb neutrons from a radioactive material of projected gamma ray and neutron emissions over a determined time period. The composition is preferably in the form of a container for storing radioactive materials that emit gamma rays and neutrons. The concrete container preferably comprises a metal liner and/or a metal outer shell. The resulting radiation shielding container has the potential of being structurally sound, stable over a long period of time, and, if desired, readily mobile. 5 figs.

  8. Terahertz radiation mixer

    DOE Patents [OSTI]

    Wanke, Michael C. (Albuquerque, NM); Allen, S. James (Santa Barbara, CA); Lee, Mark (Albuquerque, NM)

    2008-05-20

    A terahertz radiation mixer comprises a heterodyned field-effect transistor (FET) having a high electron mobility heterostructure that provides a gatable two-dimensional electron gas in the channel region of the FET. The mixer can operate in either a broadband pinch-off mode or a narrowband resonant plasmon mode by changing a grating gate bias of the FET. The mixer can beat an RF signal frequency against a local oscillator frequency to generate an intermediate frequency difference signal in the microwave region. The mixer can have a low local oscillator power requirement and a large intermediate frequency bandwidth. The terahertz radiation mixer is particularly useful for terahertz applications requiring high resolution.

  9. Small-Scale Experiments.10-gallon drum experiment summary

    SciTech Connect (OSTI)

    Rosenberg, David M.

    2015-02-05

    A series of sub-scale (10-gallon) drum experiments were conducted to characterize the reactivity, heat generation, and gas generation of mixtures of chemicals believed to be present in the drum (68660) known to have breached in association with the radiation release event at the Waste Isolation Pilot Plant (WIPP) on February 14, 2014, at a scale expected to be large enough to replicate the environment in that drum but small enough to be practical, safe, and cost effective. These tests were not intended to replicate all the properties of drum 68660 or the event that led to its breach, or to validate a particular hypothesis of the release event. They were intended to observe, in a controlled environment and with suitable diagnostics, the behavior of simple mixtures of chemicals in order to determine if they could support reactivity that could result in ignition or if some other ingredient or event would be necessary. There is a significant amount of uncertainty into the exact composition of the barrel; a limited sub-set of known components was identified, reviewed with Technical Assessment Team (TAT) members, and used in these tests. This set of experiments was intended to provide a framework to postulate realistic, data-supported hypotheses for processes that occur in a “68660-like” configuration, not definitively prove what actually occurred in 68660.

  10. Research and Education Reports Virtual International Experiences in Veterinary

    E-Print Network [OSTI]

    Singer, Randall

    in their professions. For one thing, unprecedented changes in human and animal demographics, diseases, and biotech in all areas of international health. The convergence of global issues in animal, humanResearch and Education Reports Virtual International Experiences in Veterinary Medicine

  11. Current Committee Membership Radiation Protection, Committee on

    E-Print Network [OSTI]

    Polz, Martin

    Current Committee Membership Radiation Protection, Committee on The Committee on Radiation Protection is responsible for the establishment and continuing review of an adequate radiation protection's compliance with radiation protection regulations promulgated by state, federal, and local agencies

  12. Photon Clusters in Thermal Radiation

    E-Print Network [OSTI]

    Aleksey Ilyin

    2014-10-30

    Within the framework of Bose-Einstein statistics, it is shown that the blackbody radiation, in addition to single photons, contains photon clusters, or coalescent photons. The probability to find a k-photon cluster versus radiation frequency and temperature is found, as well as the statistics of clusters. Spectra of photon-cluster radiation are calculated as functions of blackbody temperature. The Planck's radiation law is derived based on the existence of photon clusters. The possibility of experimental observation of photon clusters in thermal radiation is discussed.

  13. Radiation-induced gene responses

    SciTech Connect (OSTI)

    Woloschak, G.E.; Paunesku, T.; Shearin-Jones, P.; Oryhon, J.

    1996-12-31

    In the process of identifying genes that are differentially regulated in cells exposed to ultraviolet radiation (UV), we identified a transcript that was repressed following the exposure of cells to a combination of UV and salicylate, a known inhibitor of NF-kappaB. Sequencing this band determined that it has identify to lactate dehydrogenase, and Northern blots confirmed the initial expression pattern. Analysis of the sequence of the LDH 5` region established the presence of NF-kappaB, Sp1, and two Ap-2 elements; two partial AP- 1; one partial RE, and two halves of E-UV elements were also found. Electromobility shift assays were then performed for the AP-1, NF- kappaB, and E-UV elements. These experiments revealed that binding to NF-kappaB was induced by UV but repressed with salicylic acid; UV did not affect AP-1 binding, but salicylic acid inhibited it alone or following UV exposure; and E-UV binding was repressed by UV, and salicylic acid had little effect. Since the binding of no single element correlated with the expression pattern of LDH, it is likely that multiple elements govern UV/salicylate-mediated expression.

  14. Human factors aspects of the major upgrade to the control systems at the LANL plutonium facility

    SciTech Connect (OSTI)

    Higgins, J.C.; Pope, N.

    1997-04-01

    The Plutonium Facility (TA-55) at Los Alamos National Laboratory (LANL) has been in operation for almost 20 years. The Operations Center of TA-55 is the nerve center of the facility where operators are on duty around the clock and monitor several thousand data points using the Facility Control System (FCS). The FCS monitors, displays, alarms, and provides some limited control of several systems, including: HVAC, fire detection and suppression, radiation detection, and electrical. The FCS was failing and needed to be replaced expeditiously. This paper will discuss the human factors aspects of the design, installation, and testing of the new FCS within the above noted constraints. Particular items to be discussed include the functional requirements definition, operating experience review, screen designs, test program, operator training, and phased activation of the new circuits in an operational facility.

  15. A HUMAN PERFORMANCE MODEL OF COMMERCIAL JETLINER TAXIING Michael D. Byrne, Jeffrey C. Zemla

    E-Print Network [OSTI]

    Byrne, Mike

    performance between large-scale engineering-oriented simulations and human-in-the-loop experiments. In order are limited in several ways. One common method is to employ human-in-the-loop (HITL) experiments. In orderA HUMAN PERFORMANCE MODEL OF COMMERCIAL JETLINER TAXIING Michael D. Byrne, Jeffrey C. Zemla Rice

  16. Recognizing Human Activities from Multi-Modal Shu Chen,Yan Huang

    E-Print Network [OSTI]

    Huang, Yan

    and used in our experiments can also be accessed online. II. RELATED WORK Automatic human activities and experiments are not provided in their paper. Joshua et al. [5] use RFID-based tech- niques to detect humanRecognizing Human Activities from Multi-Modal Sensors Shu Chen,Yan Huang Department of Computer

  17. Prefrontal involvement in the regulation of emotion: convergence of rat and human studies

    E-Print Network [OSTI]

    Quirk, Gregory J.

    experiments designed to bridge human and rodent models of emotion regulation. Addresses 1 Department of prefrontal involvement of emotion regula- tion using rat and human models, and suggest future experimentsPrefrontal involvement in the regulation of emotion: convergence of rat and human studies Gregory J

  18. Computational and experimental research on infrared trace by human being contact

    SciTech Connect (OSTI)

    Xiong Zonglong; Yang Kuntao; Ding Wenxiu; Zhang Nanyangsheng; Zheng Wenheng

    2010-06-20

    The indoor detection of the human body's thermal trace plays an important role in the fields of infrared detecting, scouting, infrared camouflage, and infrared rescuing and tracking. Currently, quantitative description and analysis for this technology are lacking due to the absence of human infrared radiation analysis. To solve this problem, we study the heating and cooling process by observing body contact and removal on an object, respectively. Through finite-element simulation and carefully designed experiments, an analytical model of the infrared trace of body contact is developed based on infrared physics and heat transfer theory. Using this model, the impact of body temperature on material thermal parameters is investigated. The sensitivity of material thermal parameters, the thermal distribution, and the changes of the thermograph's contrast are then found and analyzed. Excellent matching results achieved between the simulation and the experiments demonstrate the strong impact of temperature on material thermal parameters. Conclusively, the new model, simulation, and experimental results are beneficial to the future development and implementation of infrared trace technology.

  19. Method for microbeam radiation therapy

    DOE Patents [OSTI]

    Slatkin, D.N.; Dilmanian, F.A.; Spanne, P.O.

    1994-08-16

    A method is disclosed of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation. The dose is in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue. No Drawings

  20. Method for microbeam radiation therapy

    DOE Patents [OSTI]

    Slatkin, Daniel N. (Sound Beach, NY); Dilmanian, F. Avraham (Yaphank, NY); Spanne, Per O. (Shoreham, NY)

    1994-01-01

    A method of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation, in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue.

  1. Portable controls experiments

    E-Print Network [OSTI]

    Larson, Richard Winston

    2012-01-01

    Experiments for controls classes like MIT's 2.004 require large lab setups and expensive equipment such as oscilloscopes and function generators. We developed a series of controls experiments based on National Instruments' ...

  2. Influence of Extraterrestrial Radiation on Radiation Portal Monitors

    SciTech Connect (OSTI)

    Keller, Paul E.; Kouzes, Richard T.

    2009-06-01

    Cosmic radiation and solar flares can be a major source of background radiation at the Earth’s surface. This paper examines the relationship between extraterrestrial radiation and the detectable background in radiation portal monitors used for homeland security applications. Background radiation data from 13 radiation portal monitor facilities are examined and compared against external sources of data related to extraterrestrial radiation, including measurements at neutron monitors located at 53 cosmic-ray observatories around the Earth, four polar orbiting satellites, three geostationary satellites, ground-based geomagnetic field data from observatories around the Earth, a solar magnetic index, solar radio flux data, and sunspot activity data. Four-years (January 2003 through December 2006) of data are used in this study, which include the latter part of Solar Cycle 23 as solar activity was on the decline. The analysis shows a significant relationship between some extraterrestrial radiation and the background detected in the radiation portal monitors. A demonstrable decline is shown in the average gamma ray and neutron background at the radiation portal monitors as solar activity declined over the period of the study.

  3. 2015-2016 HOUSING RATES FIRST YEAR EXPERIENCE (FYE)

    E-Print Network [OSTI]

    Elzanowski, Marek

    2015-2016 HOUSING RATES FIRST YEAR EXPERIENCE (FYE) 1977 SW 6TH AVE, SUITE 210 PORTLAND, OR 97201 PHONE: 503.725.4375 EMAIL: HOUSING@PDX.EDU WWW.PDX.EDU/HOUSING First Year Experience (FYE) is a year to their surrounding environments, communities and human rights. Located in Ondine. Themed Housing Options STEM

  4. Analysis of Contribution from Edge Radiation to Optical Diffraction Radiation

    SciTech Connect (OSTI)

    C. Liu, P. Evtushenko, A. Freyberger, C. Liu, A.H. Lumpkin

    2009-05-01

    Beam size measurement with near-field optical diffraction radiation (ODR) has been carried out successfully at CEBAF. The ODR station is installed on the Hall-A beam line after eight bending magnets. The ODR images were affected by an unexpected radiation. Some calculations for analyzing the source of the radiation will be presented. Furthermore, two schemes will be proposed to alleviate the contamination.

  5. Chemical Composition of Galactic Cosmic Rays with Space Experiments

    E-Print Network [OSTI]

    Mirko Boezio; Emiliano Mocchiutti

    2012-08-07

    The origin and properties of the cosmic radiation are one of the most intriguing question in modern astrophysics. The precise measurement of the chemical composition and energy spectra of the cosmic rays provides fundamental insight into these subjects. In this paper we will review the existing experimental data. Specifically, we will analyse results collected by space-born experiments discussing the experimental uncertainties and challenges with a focus on the PAMELA experiment.

  6. The Tropical Warm Pool International Cloud Experiment

    SciTech Connect (OSTI)

    May, Peter T.; Mather, James H.; Vaughan, Geraint; Jakob, Christian; McFarquhar, Greg; Bower, Keith; Mace, Gerald G.

    2008-05-01

    One of the most complete data sets describing tropical convection ever collected will result from the upcoming Tropical Warm Pool International Cloud Experiment (TWP-ICE) in the area around Darwin, Northern Australia in January and February 2006. The aims of the experiment, which will be operated in conjunction with the DOE Atmospheric Radiation Measurement (ARM) site in Darwin, will be to examine convective cloud systems from their initial stages through to the decay of the cirrus generated and to measure their impact on the environment. The experiment will include an unprecedented network of ground-based observations (soundings, active and passive remote sensors) combined with low, mid and high altitude aircraft for in-situ and remote sensing measurements. A crucial outcome of the experiment will be a data set suitable to provide the forcing and evaluation data required by cloud resolving and single column models as well as global climate models (GCMs) with the aim to contribute to parameterization development. This data set will provide the necessary link between the observed cloud properties and the models that are attempting to simulate them. The experiment is a large multi-agency experiment including substantial contributions from the United States DOE ARM program, ARM-UAV program, NASA, the Australian Bureau of Meteorology, CSIRO, EU programs and many universities.

  7. Effects of radiation reaction in relativistic laser acceleration

    SciTech Connect (OSTI)

    Hadad, Y.; Labun, L.; Rafelski, J.; Elkina, N.; Klier, C.; Ruhl, H. [Departments of Physics and Mathematics, University of Arizona, Tucson, Arizona, 85721 (United States); Department fuer Physik der Ludwig-Maximillians-Universitaet, Theresienstrasse 37A, 80333 Muenchen (Germany)

    2010-11-01

    The goal of this paper is twofold: to explore the response of classical charges to electromagnetic force at the level of unity in natural units and to establish a criterion that determines physical parameters for which the related radiation-reaction effects are detectable. In pursuit of this goal, the Landau-Lifshitz equation is solved analytically for an arbitrary (transverse) electromagnetic pulse. A comparative study of the radiation emission of an electron in a linearly polarized pulse for the Landau-Lifshitz equation and for the Lorentz force equation reveals the radiation-reaction-dominated regime, in which radiation-reaction effects overcome the influence of the external fields. The case of a relativistic electron that is slowed down by a counterpropagating electromagnetic wave is studied in detail. We further show that when the electron experiences acceleration of order unity, the dynamics of the Lorentz force equation, the Landau-Lifshitz equation and the Lorentz-Abraham-Dirac equation all result in different radiation emission that could be distinguished in experiment. Finally, our analytic and numerical results are compared with those appearing in the literature.

  8. Solar radiation intensity calculations 

    E-Print Network [OSTI]

    Levine, Randolph Steven

    1978-01-01

    , radiation per unit area per unit time, on a flat-plate collector is given by: I = I cos B (2. 1a) where I is the solar constant. insolation received at one astro- nomical unit from the sun. Since clear sky conditions are assumed I o w i 1 1 b e a.... INSOLATION EQUATIONS TABLE OF CONTENTS Page III. RESULTS AND CONCLUSIONS REFERENCES APPENDIX VITA 25 47 48 52 Vi LIST OF TABLES TABLE I. Optimal Inclination for Ap=O, No Checks for Ip &0 and a Time Independent Solar Constant. II. Optimal...

  9. Radiation imaging apparatus

    DOE Patents [OSTI]

    Anger, H.O.; Martin, D.C.; Lampton, M.L.

    1983-07-26

    A radiation imaging system using a charge multiplier and a position sensitive anode in the form of periodically arranged sets of interconnected anode regions for detecting the position of the centroid of a charge cloud arriving thereat from the charge multiplier. Various forms of improved position sensitive anodes having single plane electrode connections are disclosed. Various analog and digital signal processing systems are disclosed, including systems which use the fast response of microchannel plates, anodes and preamps to perform scintillation pulse height analysis digitally. 15 figs.

  10. Radiation imaging apparatus

    DOE Patents [OSTI]

    Anger, Hal O. (Berkeley, CA); Martin, Donn C. (Berkeley, CA); Lampton, Michael L. (Berkeley, CA)

    1983-01-01

    A radiation imaging system using a charge multiplier and a position sensitive anode in the form of periodically arranged sets of interconnected anode regions for detecting the position of the centroid of a charge cloud arriving thereat from the charge multiplier. Various forms of improved position sensitive anodes having single plane electrode connections are disclosed. Various analog and digital signal processing systems are disclosed, including systems which use the fast response of microchannel plates, anodes and preamps to perform scintillation pulse height analysis digitally.

  11. RADIATION LABORATO DISCLAIMER

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMassR&D100 Winners * Impacts on Global Technology OUTSIDE FRONT7a.R : . . . RADIATION

  12. Radiative Processes Working Group

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration wouldMassR&D100 Winners * Impacts on GlobalRachel RuggirelloRadiative Influences onmeeting,

  13. Radiation.cdr

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservation of Fe(II) by Carbon-RichProton Delivery andInnovationsRSSProtectionRadiation

  14. Radiation Control Program and Radiation Control Act (Nebraska)

    Broader source: Energy.gov [DOE]

    This statute authorizes the state to implement a regulatory program for sources of radiation, and contains rules for the Department, licensing and registration, and taxation of radioactive materials.

  15. Thermal radiation, radiation force and dynamics of a polarizable particle

    E-Print Network [OSTI]

    G. V. Dedkov; A. A. Kyasov

    2015-08-26

    We discuss basic expressions and interrelations between various physical quantities describing the fluctuation-electromagnetic interaction of a small polarizable particle during relativistic motion relative to the blackbody radiation, namely tangential radiation force, rate of heating, intensity of thermal radiation/absorption, the change of the rest mass of a particle, and acceleration. We obtain an explicit formula for the frictional force acting on the particle in its rest frame and discuss its connection with the particle acceleration and the tangential force given in the reference frame of background radiation. The criticism of our previous results in recent paper by A. I. Volokitin (Phys. Rev. A81, 2015, 032505) is refuted.

  16. DOE 2010 occupational radiation exposure

    SciTech Connect (OSTI)

    none,

    2011-11-01

    The U.S. Department of Energy (DOE) Office of Analysis within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE.* The DOE 2010 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with DOE Part 835 dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past 5 years.

  17. RADIATION TRANSPORT FOR EXPLOSIVE OUTFLOWS: OPACITY REGROUPING

    SciTech Connect (OSTI)

    Wollaeger, Ryan T. [Department of Nuclear Engineering and Engineering Physics, University of Wisconsin, Madison 1500 Engineering Drive, 410 ERB, Madison, WI 53706 (United States); Van Rossum, Daniel R., E-mail: wollaeger@wisc.edu, E-mail: daan@flash.uchicago.edu [Flash Center for Computational Science, Department of Astronomy and Astrophysics, University of Chicago, Chicago, IL 60637 (United States)

    2014-10-01

    Implicit Monte Carlo (IMC) and Discrete Diffusion Monte Carlo (DDMC) are methods used to stochastically solve the radiative transport and diffusion equations, respectively. These methods combine into a hybrid transport-diffusion method we refer to as IMC-DDMC. We explore a multigroup IMC-DDMC scheme that in DDMC, combines frequency groups with sufficient optical thickness. We term this procedure ''opacity regrouping''. Opacity regrouping has previously been applied to IMC-DDMC calculations for problems in which the dependence of the opacity on frequency is monotonic. We generalize opacity regrouping to non-contiguous groups and implement this in SuperNu, a code designed to do radiation transport in high-velocity outflows with non-monotonic opacities. We find that regrouping of non-contiguous opacity groups generally improves the speed of IMC-DDMC radiation transport. We present an asymptotic analysis that informs the nature of the Doppler shift in DDMC groups and summarize the derivation of the Gentile-Fleck factor for modified IMC-DDMC. We test SuperNu using numerical experiments including a quasi-manufactured analytic solution, a simple 10 group problem, and the W7 problem for Type Ia supernovae. We find that opacity regrouping is necessary to make our IMC-DDMC implementation feasible for the W7 problem and possibly Type Ia supernova simulations in general. We compare the bolometric light curves and spectra produced by the SuperNu and PHOENIX radiation transport codes for the W7 problem. The overall shape of the bolometric light curves are in good agreement, as are the spectra and their evolution with time. However, for the numerical specifications we considered, we find that the peak luminosity of the light curve calculated using SuperNu is ?10% less than that calculated using PHOENIX.

  18. Cellular transformation by radiation: induction, promotion, and inhibition

    SciTech Connect (OSTI)

    Borek, C.

    1981-01-01

    Radiation oncogenesis induced in utero in hamsters is expressed at a lower frequency than that induced in vitro. Quantitative studies carried out on hamster embryo cells indicate that neutrons are more effective in their carcinogenic potential than x-rays but also more toxic, that splitting the dose of x-rays at low doses leads to enhanced transformation, but that at high doses protracted radiation has a sparing effect. At all dose ranges survival was increased by protracting the radiation dose, thus suggesting that different repair processes must be involved for survival and transformation. In our qualitative studies, once cells are transformed by radiation, they exhibit a wide range of structural and functional phenotypic changes, some of which are membrane-associated and are expressed within days after induction. Our current studies on nutritional and hormonal influences on radiation transformation indicate the following: Pyrolysate products from broiled protein foods act in synergism with radiation to produce transformation, whereas vitamin A analogs are powerful, preventive agents. Retinoids inhibit both x-ray-induced transformation and its promotion by TPA; these modifications (enhancement by TPA, inhibition by retinoids) are not reflected in sister chromatid exchanges, but are reflected in the level of membrane associated enzymes Na/K ATPase. Whereas retinoids modify late events (expression, promotion), we find that thyroid hormone plays a crucial role in the early phases of radiation and chemically induced transformation. Our recent success in transforming human skin fibroblasts will enable quantitative and qualitative studies of radiation carcinogenesis in a system relevant to man.

  19. Radiation Embrittlement Archive Project

    SciTech Connect (OSTI)

    Klasky, Hilda B; Bass, Bennett Richard; Williams, Paul T; Phillips, Rick; Erickson, Marjorie A; Kirk, Mark T; Stevens, Gary L

    2013-01-01

    The Radiation Embrittlement Archive Project (REAP), which is being conducted by the Probabilistic Integrity Safety Assessment (PISA) Program at Oak Ridge National Laboratory under funding from the U.S. Nuclear Regulatory Commission s (NRC) Office of Nuclear Regulatory Research, aims to provide an archival source of information about the effect of neutron radiation on the properties of reactor pressure vessel (RPV) steels. Specifically, this project is an effort to create an Internet-accessible RPV steel embrittlement database. The project s website, https://reap.ornl.gov, provides information in two forms: (1) a document archive with surveillance capsule(s) reports and related technical reports, in PDF format, for the 104 commercial nuclear power plants (NPPs) in the United States, with similar reports from other countries; and (2) a relational database archive with detailed information extracted from the reports. The REAP project focuses on data collected from surveillance capsule programs for light-water moderated, nuclear power reactor vessels operated in the United States, including data on Charpy V-notch energy testing results, tensile properties, composition, exposure temperatures, neutron flux (rate of irradiation damage), and fluence, (Fast Neutron Fluence a cumulative measure of irradiation for E>1 MeV). Additionally, REAP contains data from surveillance programs conducted in other countries. REAP is presently being extended to focus on embrittlement data analysis, as well. This paper summarizes the current status of the REAP database and highlights opportunities to access the data and to participate in the project.

  20. KRFTWRK – Global Human Electricity

    E-Print Network [OSTI]

    Prohaska, Rainer

    2009-01-01

    in the generation of human power, where energy is gained byparticipant runs a virtual human power plant. Per every "by muscle-power and chemical processes of human bodies. For

  1. Performance of the AMS-02 Transition Radiation Detector

    E-Print Network [OSTI]

    P. v. Doetinchem; S. Fopp; W. Karpinski; T. Kirn; K. Luebelsmeyer; J. Orboeck; S. Schael; A. Schultz von Dratzig; G. Schwering; T. Siedenburg; R. Siedling; W. Wallraff; U. Becker; J. Burger; R. Henning; A. Kounine; V. Koutsenko; J. Wyatt

    2006-08-29

    For cosmic particle spectroscopy on the International Space Station the AMS experiment will be equipped with a Transition Radiation Detector (TRD) to improve particle identification. The TRD has 20 layers of fleece radiator with Xe/CO2 proportional mode straw tube chambers. They are supported in a conically shaped octagon structure made of CFC-Al-honeycomb. For low power consumption VA analog multiplexers are used as front-end readout. A 20 layer prototype built from final design components has achieved proton rejections from 100 to 2000 at 90% electron efficiency for proton beam energies up to 250 GeV with cluster counting, likelihood and neural net selection algorithms.

  2. Theory of Light Emission in Sonoluminescence as Thermal Radiation

    E-Print Network [OSTI]

    Wang-Kong Tse; P. T. Leung

    2006-06-14

    Based on the model proposed by Hilgenfeldt {\\it at al.} [Nature {\\bf 398}, 401 (1999)], we present here a comprehensive theory of thermal radiation in single-bubble sonoluminescence (SBSL). We first invoke the generalized Kirchhoff's law to obtain the thermal emissivity from the absorption cross-section of a multilayered sphere (MLS). A sonoluminescing bubble, whose internal structure is determined from hydrodynamic simulations, is then modelled as a MLS and in turn the thermal radiation is evaluated. Numerical results obtained from simulations for argon bubbles show that our theory successfully captures the major features observed in SBSL experiments.

  3. Wireless Communication Enhancement Methods for Mobile Robots in Radiation Environments

    E-Print Network [OSTI]

    Nattanmai Parasuraman, Ramviyas; Ferre, Manuel

    In hostile environments such as in scientific facilities where ionising radiation is a dominant hazard, reducing human interventions by increasing robotic operations are desirable. CERN, the European Organization for Nuclear Research, has around 50 km of underground scientific facilities, where wireless mobile robots could help in the operation of the accelerator complex, e.g. in conducting remote inspections and radiation surveys in different areas. The main challenges to be considered here are not only that the robots should be able to go over long distances and operate for relatively long periods, but also the underground tunnel environment, the possible presence of electromagnetic fields, radiation effects, and the fact that the robots shall in no way interrupt the operation of the accelerators. Having a reliable and robust wireless communication system is essential for successful execution of such robotic missions and to avoid situations of manual recovery of the robots in the event that the robot runs ...

  4. RSSC RADIATION DETECTORS & SURVEY INSTRUMENTS 8/99 4-1 RADIATION DETECTORS AND SURVEY INSTRUMENTS

    E-Print Network [OSTI]

    Slatton, Clint

    RSSC RADIATION DETECTORS & SURVEY INSTRUMENTS 8/99 4-1 CHAPTER 4 RADIATION DETECTORS AND SURVEY........................................................................................................... 4-3 II. Use of Radiation Survey Instruments

  5. Electromagnetic radiation by gravitating bodies

    E-Print Network [OSTI]

    Iwo Bialynicki-Birula; Zofia Bialynicka-Birula

    2008-05-06

    Gravitating bodies in motion, regardless of their constitution, always produce electromagnetic radiation in the form of photon pairs. This phenomenon is an analog of the radiation caused by the motion of dielectric (or magnetic) bodies. It is a member of a wide class of phenomena named dynamical Casimir effects, and it may be viewed as the squeezing of the electromagnetic vacuum. Production of photon pairs is a purely quantum-mechanical effect. Unfortunately, as we show, the emitted radiation is extremely weak as compared to radiation produced by other mechanisms.

  6. Quality Services: Radiation (New York)

    Broader source: Energy.gov [DOE]

    These regulations establish standards for protection against ionizing radiation resulting from the disposal and discharge of radioactive material to the environment. The regulations apply to any...

  7. Radiation Shielding and Radiological Protection

    E-Print Network [OSTI]

    Shultis, J. Kenneth

    Radiation Shielding and Radiological Protection J. Kenneth Shultis Richard E. Faw Department Shielding and Radiological Protection .. Example Calculations for Distributed Sources

  8. Scintillator Waveguide For Sensing Radiation

    DOE Patents [OSTI]

    Bliss, Mary (West Richland, WA); Craig, Richard A. (West Richland, WA); Reeder; Paul L. (Richland, WA)

    2003-04-22

    The present invention is an apparatus for detecting ionizing radiation, having: a waveguide having a first end and a second end, the waveguide formed of a scintillator material wherein the therapeutic ionizing radiation isotropically generates scintillation light signals within the waveguide. This apparatus provides a measure of radiation dose. The apparatus may be modified to permit making a measure of location of radiation dose. Specifically, the scintillation material is segmented into a plurality of segments; and a connecting cable for each of the plurality of segments is used for conducting scintillation signals to a scintillation detector.

  9. Human-machine interactions

    DOE Patents [OSTI]

    Forsythe, J. Chris (Sandia Park, NM); Xavier, Patrick G. (Albuquerque, NM); Abbott, Robert G. (Albuquerque, NM); Brannon, Nathan G. (Albuquerque, NM); Bernard, Michael L. (Tijeras, NM); Speed, Ann E. (Albuquerque, NM)

    2009-04-28

    Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

  10. Jefferson Lab Human Resources

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources The Human Resources team is fully integrated with Jefferson Lab's mission, committed to providing quality customer service based on expertise, innovation and...

  11. Radiation Hydrodynamics Scaling Laws in High Energy Density Physics and Laboratory Astrophysics

    E-Print Network [OSTI]

    Emeric Falize; Serge Bouquet; Claire Michaut

    2008-05-20

    In this paper, radiating fluids scaling laws are studied. We focus on optically thin and optically thick regimes which are relevant for both astrophysics and laboratory experiments. By using homothetic Lie groups, we obtain the scaling laws, the similarity properties and the number of free parameters which allow to rescale experiments in the two astrophyscial situations.

  12. Double Beta Decay Experiments

    SciTech Connect (OSTI)

    Nanal, Vandana [Dept. of Nuclear and Atomic Physics, Tata Institute of Fundamental Research, Mumbai 400 005 (India)

    2011-11-23

    At present, neutrinoless double beta decay is perhaps the only experiment that can tell us whether the neutrino is a Dirac or a Majorana particle. Given the significance of the 0{nu}{beta}{beta}, there is a widespread interest for these rare event studies employing a variety of novel techniques. This paper describes the current status of DBD experiments. The Indian effort for an underground NDBD experiment at the upcoming INO laboratory is also presented.

  13. Non-Targeted Effects Induced by Ionizing Radiation: Mechanisms and Potential Impact on Radiation Induced Health Effects

    SciTech Connect (OSTI)

    Morgan, William F.; Sowa, Marianne B.

    2015-01-01

    Not-targeted effects represent a paradigm shift from the "DNA centric" view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (> 1Gy), at low doses (< 100mGy) non-targeted effects associated with radiation exposure might play a significant role. Here definitions of non-targeted effects are presented, the potential mechanisms for the communication of signals and signaling networks from irradiated cells/tissues are proposed, and the various effects of this intra- and intercellular signaling are described. We conclude with speculation on how these observations might lead to and impact long-term human health outcomes.

  14. Nuclear Physics: Experiment Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Free Electron Laser (FEL) Medical Imaging Physics Topics Campaigns Meetings Recent Talks Archived Talks Additional Information Computing at JLab Operations Logbook Experiment...

  15. Biologically based multistage modeling of radiation effects

    SciTech Connect (OSTI)

    William Hazelton; Suresh Moolgavkar; E. Georg Luebeck

    2005-08-30

    This past year we have made substantial progress in modeling the contribution of homeostatic regulation to low-dose radiation effects and carcinogenesis. We have worked to refine and apply our multistage carcinogenesis models to explicitly incorporate cell cycle states, simple and complex damage, checkpoint delay, slow and fast repair, differentiation, and apoptosis to study the effects of low-dose ionizing radiation in mouse intestinal crypts, as well as in other tissues. We have one paper accepted for publication in ''Advances in Space Research'', and another manuscript in preparation describing this work. I also wrote a chapter describing our combined cell-cycle and multistage carcinogenesis model that will be published in a book on stochastic carcinogenesis models edited by Wei-Yuan Tan. In addition, we organized and held a workshop on ''Biologically Based Modeling of Human Health Effects of Low dose Ionizing Radiation'', July 28-29, 2005 at Fred Hutchinson Cancer Research Center in Seattle, Washington. We had over 20 participants, including Mary Helen Barcellos-Hoff as keynote speaker, talks by most of the low-dose modelers in the DOE low-dose program, experimentalists including Les Redpath (and Mary Helen), Noelle Metting from DOE, and Tony Brooks. It appears that homeostatic regulation may be central to understanding low-dose radiation phenomena. The primary effects of ionizing radiation (IR) are cell killing, delayed cell cycling, and induction of mutations. However, homeostatic regulation causes cells that are killed or damaged by IR to eventually be replaced. Cells with an initiating mutation may have a replacement advantage, leading to clonal expansion of these initiated cells. Thus we have focused particularly on modeling effects that disturb homeostatic regulation as early steps in the carcinogenic process. There are two primary considerations that support our focus on homeostatic regulation. First, a number of epidemiologic studies using multistage carcinogenesis models that incorporate the ''initiation, promotion, and malignant conversion'' paradigm of carcinogenesis are indicating that promotion of initiated cells is the most important cellular mechanism driving the shape of the age specific hazard for many types of cancer. Second, we have realized that many of the genes that are modified in early stages of the carcinogenic process contribute to one or more of four general cellular pathways that confer a promotional advantage to cells when these pathways are disrupted.

  16. Measurement of accelerator neutron radiation field spectrum by Extended Range Neutron Multisphere Spectrometers and unfolding program

    E-Print Network [OSTI]

    Li, Guanjia; Ma, Zhongjian; Guo, Siming; Yan, Mingyang; Shi, Haoyu; Xu, Chao

    2015-01-01

    This paper described a measurement of accelerator neutron radiation field at a transport beam line of Beijing-TBF. The experiment place was be selected around a Faraday Cup with a graphite target impacted by electron beam at 2.5GeV. First of all, we simulated the neutron radiation experiment by FLUKA. Secondly, we chose six appropriate ERNMS according to their neutron fluence response function to measure the neutron count rate. Then the U_M_G package program was be utilized to unfolding experiment data. Finally, we drew a comparison between the unfolding with the simulation spectrum and made an analysis about the result.

  17. Experiment summary for n/y attenuation through materials (Environments 1A).

    SciTech Connect (OSTI)

    DePriest, Kendall Russell

    2006-05-01

    The Radiation Effects Sciences (RES) program is responsible for conducting Neutron Gamma Energy Transport (NuGET) code validation. In support of this task, a series of experiments were conducted in the annular core research reactor (ACRR) to investigate the modification of the incident neutron/gamma environment by aluminum (Al6061) and high-density polyethylene (HDPE) spheres with 4-in and 7-in-diameter. The experiment series described in this report addresses several NuGET validation concerns. The validation experiment series also addresses the design and execution of proper reactor testing to match the hostile radiation environments and to match the component stresses that arise from the hostile radiation environments. This report summarizes the RES Validation: n/{gamma} Attenuation through Materials, Environments 1A, experiments conducted at the ACRR in FY 2003 using ACRR Experiment Plans 933 and 949.

  18. St. Louis Sites Fact Sheet RADIATION BASICS

    E-Print Network [OSTI]

    US Army Corps of Engineers

    , radiation is described as either non-ionizing (low energy) or ionizing (high energy). Non-ionizing radiation or concrete. WHAT IS DOSE? HOW IS RADIATION MEASURED? The dose is the quantity of radiation or energy received dose and takes into account the type of radiation absorbed into the body and the likelihood of damage

  19. UNIVERSITY OF TORONTO RADIATION PROTECTION SERVICE

    E-Print Network [OSTI]

    Chan, Hue Sun

    UNIVERSITY OF TORONTO RADIATION PROTECTION SERVICE MEMORANDUM SUBJECT: SAFE USE OF RADIOGRAPHY, visitors, or experimental animals, plants, or cell lines, the Radiation Protection Service has a permit to the Radiation Protection Service. Sandu Sonoc Radiation Safety Officer 416-978-2028 Hector Rocca Radiation

  20. THE UNIVERSITY OF UTAH RADIATION PROTECTION PROGRAM

    E-Print Network [OSTI]

    THE UNIVERSITY OF UTAH RADIATION PROTECTION PROGRAM The use of radiation sources at the University. The Radiation Safety Policy Manual contains the policies and general procedures for radiation protection of Utah entails both legal and moral obligations to provide training on the nature of radiation sources

  1. RADIATION SAFETY MANUAL 2014 RICE UNIVERSITY 1

    E-Print Network [OSTI]

    Natelson, Douglas

    microscopes. Notify the RSO of any new radiation sources. Notify the RSO if any radiation sources with radioactive materials must attend formal radiation safety training provided by EHS. #12;RADIATION SAFETY with information concerning risk. 4. Provide suggestions for reducing exposure. 5. Monitor your radiation dose wit

  2. Review Article RADIATION SHIELDING TECHNOLOGY

    E-Print Network [OSTI]

    Shultis, J. Kenneth

    Review Article RADIATION SHIELDING TECHNOLOGY J. Kenneth Shultis and Richard E. Faw* Abstract Physics Society INTRODUCTION THIS IS a review of the technology of shielding against the effects to the review. The first treats the evolution of radiation-shielding technology from the beginning of the 20th

  3. RADIATION AND CLOUD MONITORING STATIONS

    E-Print Network [OSTI]

    Reeves, Geoffrey D.

    how they affect the energy balance between incoming solar radiation and heat re-radiated from Earth's surface back into space -- is crucial to improving the general circulation models used for climate students. #12;A MONTHLY PUBLICATION OF THE PUBLIC AFFAIRS OFFICE OF LOS ALAMOS NATIONAL LABORATORY LOS

  4. Pacific Northwest Solar Radiation Data

    E-Print Network [OSTI]

    Oregon, University of

    Pacific Northwest Solar Radiation Data UO SOLAR MONITORING LAB Physics Department -- Solar Energy Center 1274 University of Oregon Eugene, Oregon 97403-1274 April 1, 1999 #12;Hourly solar radiation data can be obtained from the University of Oregon Solar Moni- toring Laboratory after obtaining permission

  5. Position Sensitive Radiation Detector Integrated with an FPGA for Radiation Tolerant Computing

    E-Print Network [OSTI]

    LaMeres, Brock J.

    Position Sensitive Radiation Detector Integrated with an FPGA for Radiation Tolerant Computing radiation sensor was modeled, developed and fabricated then interfaced with a field programmable gate array (FPGA) to create a radiation hardened computing platform. The system exploits environmental information

  6. Franklin: User Experiences

    SciTech Connect (OSTI)

    National Energy Research Supercomputing Center; He, Yun; Kramer, William T.C.; Carter, Jonathan; Cardo, Nicholas

    2008-05-07

    The newest workhorse of the National Energy Research Scientific Computing Center is a Cray XT4 with 9,736 dual core nodes. This paper summarizes Franklin user experiences from friendly early user period to production period. Selected successful user stories along with top issues affecting user experiences are presented.

  7. International Experience Singapore 2014

    E-Print Network [OSTI]

    Subramanian, Venkat

    , energy and environmental issues in India, alternative energy and technology in China and Hong KongInternational Experience Singapore 2014 Department of Energy, Environmental And Chemical Experience Program is part of the McDonnell International Scholars Academy Global Energy & Environment

  8. Radiative recombination data for tungsten ions: II. W{sup 47+}–W{sup 71+}

    SciTech Connect (OSTI)

    Trzhaskovskaya, M.B., E-mail: Trzhask@MT5605.spb.edu [Petersburg Nuclear Physics Institute, Gatchina 188300 (Russian Federation); Nikulin, V.K. [Ioffe Physical Technical Institute, St. Petersburg 194021 (Russian Federation)

    2014-07-15

    New radiative recombination and photoionization cross sections, radiative recombination rate coefficients, and radiated power loss rate coefficients are presented for 23 tungsten impurity ions in plasmas. We consider ions from W{sup 47+} to W{sup 71+} that are of importance to fusion studies for ITER and for experiments using electron beam ion traps. The calculations are fully relativistic and all significant multipoles of the radiative field are taken into account. The Dirac–Fock method is used to compute the electron wavefunctions. Radiative recombination rates and radiated power loss rates are found using the relativistic Maxwell–Jüttner distribution of the continuum electron velocity. The total radiative recombination cross sections are given in the electron energy range from 1 eV to ?80keV. Partial cross sections for ground and excited states are approximated by an analytical expression involving five fit parameters. Radiative recombination rates and radiated power loss rates are calculated in the temperature range from 10{sup 4}K to 10{sup 9}K. The total radiative recombination rates are approximated by another analytical expression with four fit parameters.

  9. Studying Gestures: The Iconic Roots of Human Communication Systems 

    E-Print Network [OSTI]

    Ioannou, Charis

    2011-11-23

    This paper tests the hypothesis that the iconicity inherent in human gestures can be a key element in the creation and evolution of communication systems. An interactive experiment based on playing charades was conducted modelling a situation where...

  10. Alternative Methods for Human Identification: Mitochondrial DNA Base Composition Profiling

    E-Print Network [OSTI]

    Applied Genetics Alternative Methods for Human Identification: Mitochondrial DNA Base Composition · Evaluation Experiments · Future directions #12;Applied Genetics Mitochondrial DNA · Mitochondria are organelles within cells ­ Produce energy via the Krebs Cycle · Separate genome from the nucleus ­ 16,569 bp

  11. Nonproportionality of Scintillator Detectors: Theory and Experiment

    E-Print Network [OSTI]

    Moses, William

    2010-01-01

    12] G. F. Knoll, Radiation Detection and Measurements, JohnEnergy nonlinearity in radiation detection materials: Causes

  12. human spaceflight and operations

    E-Print Network [OSTI]

    Anand, Mahesh

    1 human spaceflight and operations Lunar Lander human spaceflight and operations #12;2 human cooperation in exploration prim ary objective opportunity for investigations #12;3 human spaceflight No RHUs LANDING SITE South Polar Reliant on Solar Power generation + conventional thermal control LAUNCHER

  13. A model code for the radiative theta pinch

    SciTech Connect (OSTI)

    Lee, S.; Saw, S. H.; Lee, P. C. K.; Akel, M.; Damideh, V.; Khattak, N. A. D.; Mongkolnavin, R.; Paosawatyanyong, B.

    2014-07-15

    A model for the theta pinch is presented with three modelled phases of radial inward shock phase, reflected shock phase, and a final pinch phase. The governing equations for the phases are derived incorporating thermodynamics and radiation and radiation-coupled dynamics in the pinch phase. A code is written incorporating correction for the effects of transit delay of small disturbing speeds and the effects of plasma self-absorption on the radiation. Two model parameters are incorporated into the model, the coupling coefficient f between the primary loop current and the induced plasma current and the mass swept up factor f{sub m}. These values are taken from experiments carried out in the Chulalongkorn theta pinch.

  14. Modeling Human Foraging Brian D. Glass

    E-Print Network [OSTI]

    Maddox, W. Todd

    Modeling Human Foraging Brian D. Glass Department of Psychology University of Texas at Austin Thanks to W. Todd Maddox Arthur B. Markman Scott Lauritzen Cognition & Perception Group #12;Foraging What from group experiments like these? You learn about group behavior, with little to say about behavior

  15. Experiment to Characterize Tropical Cloud Systems

    SciTech Connect (OSTI)

    May, Peter T.; Mather, Jim H.; Jakob, Christian

    2005-08-02

    A major experiment to study tropical convective cloud systems and their impacts will take place around Darwin, Northern Australia in early 2006. The Tropical Warm Pool International Cloud Experiment (TWP-ICE) is a collaboration including the DOE ARM (Atmospheric Radiation Measurement) and ARM-UAV programs, NASA centers, the Australian Bureau of Meteorology, CSIRO, and universities in the USA, Australia, Japan, the UK, and Canada. TWP-ICE will be preceded in November/December 2004 by a collaborating European aircraft campaign involving the EU SCOUT-O3 and UK NERC ACTIVE projects. Detailed atmospheric measurements will be made in the Darwin area through the whole Austral summer, giving unprecedented coverage through the pre-monsoon and monsoon periods.

  16. Central Equatorial Pacific Experiment (CEPEX)

    SciTech Connect (OSTI)

    Not Available

    1993-01-01

    The Earth's climate has varied significantly in the past, yet climate records reveal that in the tropics, sea surface temperatures seem to have been remarkably stable, varying by less than a few degrees Celsius over geologic time. Today, the large warm pool of the western Pacific shows similar characteristics. Its surface temperature always exceeds 27[degree]C, but never 31[degree]C. Heightened interest in this observation has been stimulated by questions of global climate change and the exploration of stabilizing climate feedback processes. Efforts to understand the observed weak sensitivity of tropical sea surface temperatures to climate forcing has led to a number of competing ideas about the nature of this apparent thermostat. Although there remains disagreement on the processes that regulate tropical sea surface temperature, most agree that further progress in resolving these differences requires comprehensive field observations of three-dimensional water vapor concentrations, solar and infrared radiative fluxes, surface fluxes of heat and water vapor, and cloud microphysical properties. This document describes the Central Equatorial Pacific Experiment (CEPEX) plan to collect such observations over the central equatorial Pacific Ocean during March of 1993.

  17. Meeting Report--NASA Radiation Biomarker Workshop

    E-Print Network [OSTI]

    Straume, Tore

    2008-01-01

    analysis of low–dose radiation -associated changes incellular responses to low-dose radiation using genomic gene-cellular responses to low-dose radiation and to reduce the

  18. Mesenchymal Stem Cells Retain Their Defining Stem Cell Characteristics After Exposure to Ionizing Radiation

    SciTech Connect (OSTI)

    Nicolay, Nils H.; Sommer, Eva; Lopez, Ramon; Wirkner, Ute; Trinh, Thuy; Sisombath, Sonevisay; Debus, Jürgen; Ho, Anthony D.; Saffrich, Rainer; Huber, Peter E.

    2013-12-01

    Purpose: Mesenchymal stem cells (MSCs) have the ability to migrate to lesion sites and undergo differentiation into functional tissues. Although this function may be important for tissue regeneration after radiation therapy, the influence of ionizing radiation (IR) on cellular survival and the functional aspects of differentiation and stem cell characteristics of MSCs have remained largely unknown. Methods and Materials: Radiation sensitivity of human primary MSCs from healthy volunteers and primary human fibroblast cells was examined, and cellular morphology, cell cycle effects, apoptosis, and differentiation potential after exposure to IR were assessed. Stem cell gene expression patterns after exposure to IR were studied using gene arrays. Results: MSCs were not more radiosensitive than human primary fibroblasts, whereas there were considerable differences regarding radiation sensitivity within individual MSCs. Cellular morphology, cytoskeletal architecture, and cell motility were not markedly altered by IR. Even after high radiation doses up to 10 Gy, MSCs maintained their differentiation potential. Compared to primary fibroblast cells, MSCs did not show an increase in irradiation-induced apoptosis. Gene expression analyses revealed an upregulation of various genes involved in DNA damage response and DNA repair, but expression of established MSC surface markers appeared only marginally influenced by IR. Conclusions: These data suggest that human MSCs are not more radiosensitive than differentiated primary fibroblasts. In addition, upon photon irradiation, MSCs were able to retain their defining stem cell characteristics both on a functional level and regarding stem cell marker expression.

  19. The radiation chemistry of ionic liquids: A review

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mincher, Bruce J.; Wishart, James F.

    2014-07-03

    Ionic liquids have received increasing attention as media for radiochemical separations. Recent literature includes examinations of the efficiencies and mechanisms of the solvent extraction of lanthanides, actinides and fission products into ionic liquid solutions. For radiochemical applications, including as replacement solvents for nuclear fuel reprocessing, a thorough understanding of the radiation chemistry of ionic liquids will be required. Such an understanding can be achieved based on a combination of steady-state radiolysis experiments coupled with post-irradiation product identification and pulse-radiolysis experiments to acquire kinetic information. These techniques allow for the elucidation of radiolytic mechanisms. This contribution reviews the current ionic liquidmore »radiation chemistry literature as it affects separations, with these considerations in mind.« less

  20. The radiation chemistry of ionic liquids: a review

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mincher, Bruce J.; Wishart, James F.

    2014-07-03

    Ionic liquids have received increasing attention as media for radiochemical separations. Recent literature includes examinations of the efficiencies and mechanisms of the solvent extraction of lanthanides, actinides and fission products into ionic liquid solutions. For radiochemical applications, including as replacement solvents for nuclear fuel reprocessing, a thorough understanding of the radiation chemistry of ionic liquids will be required. Such an understanding can be achieved based upon a combination of steady-state radiolysis experiments coupled with post-irradiation product identification and pulse-radiolysis experiments to acquire kinetic information. These techniques allow for the elucidation of radiolytic mechanisms. This contribution reviews the current ionic liquid radiation chemistry literature as it affects separations, with these considerations in mind.

  1. The radiation chemistry of ionic liquids: A review

    SciTech Connect (OSTI)

    Mincher, Bruce J.; Wishart, James F.

    2014-07-03

    Ionic liquids have received increasing attention as media for radiochemical separations. Recent literature includes examinations of the efficiencies and mechanisms of the solvent extraction of lanthanides, actinides and fission products into ionic liquid solutions. For radiochemical applications, including as replacement solvents for nuclear fuel reprocessing, a thorough understanding of the radiation chemistry of ionic liquids will be required. Such an understanding can be achieved based on a combination of steady-state radiolysis experiments coupled with post-irradiation product identification and pulse-radiolysis experiments to acquire kinetic information. These techniques allow for the elucidation of radiolytic mechanisms. This contribution reviews the current ionic liquid radiation chemistry literature as it affects separations, with these considerations in mind.

  2. Modeling aspects of human memory for scientific study.

    SciTech Connect (OSTI)

    Caudell, Thomas P. (University of New Mexico); Watson, Patrick (University of Illinois - Champaign-Urbana Beckman Institute); McDaniel, Mark A. (Washington University); Eichenbaum, Howard B. (Boston University); Cohen, Neal J. (University of Illinois - Champaign-Urbana Beckman Institute); Vineyard, Craig Michael; Taylor, Shawn Ellis; Bernard, Michael Lewis; Morrow, James Dan; Verzi, Stephen J.

    2009-10-01

    Working with leading experts in the field of cognitive neuroscience and computational intelligence, SNL has developed a computational architecture that represents neurocognitive mechanisms associated with how humans remember experiences in their past. The architecture represents how knowledge is organized and updated through information from individual experiences (episodes) via the cortical-hippocampal declarative memory system. We compared the simulated behavioral characteristics with those of humans measured under well established experimental standards, controlling for unmodeled aspects of human processing, such as perception. We used this knowledge to create robust simulations of & human memory behaviors that should help move the scientific community closer to understanding how humans remember information. These behaviors were experimentally validated against actual human subjects, which was published. An important outcome of the validation process will be the joining of specific experimental testing procedures from the field of neuroscience with computational representations from the field of cognitive modeling and simulation.

  3. The Neutron EDM Experiment

    E-Print Network [OSTI]

    P. G. Harris

    2007-12-05

    The neutron EDM experiment has played an important part over many decades in shaping and constraining numerous models of CP violation. This review article discusses some of the techniques used to calculate EDMs under various theoretical scenarios, and highlights some of the implications of EDM limits upon such models. A pedagogical introduction is given to the experimental techniques employed in the recently completed ILL experiment, including a brief discussion of the dominant systematic uncertainties. A new and much more sensitive version of the experiment, which is currently under development, is also outlined.

  4. Radiation-induced lung injury

    SciTech Connect (OSTI)

    Rosiello, R.A.; Merrill, W.W. )

    1990-03-01

    The use of radiation therapy is limited by the occurrence of the potentially fatal clinical syndromes of radiation pneumonitis and fibrosis. Radiation pneumonitis usually becomes clinically apparent from 2 to 6 months after completion of radiation therapy. It is characterized by fever, cough, dyspnea, and alveolar infiltrates on chest roentgenogram and may be difficult to differentiate from infection or recurrent malignancy. The pathogenesis is uncertain, but appears to involve both direct lung tissue toxicity and an inflammatory response. The syndrome may resolve spontaneously or may progress to respiratory failure. Corticosteroids may be effective therapy if started early in the course of the disease. The time course for the development of radiation fibrosis is later than that for radiation pneumonitis. It is usually present by 1 year following irradiation, but may not become clinically apparent until 2 years after radiation therapy. It is characterized by the insidious onset of dyspnea on exertion. It most often is mild, but can progress to chronic respiratory failure. There is no known successful treatment for this condition. 51 references.

  5. Radiative Gaugino Masses

    E-Print Network [OSTI]

    Glennys R. Farrar; Antonio Masiero

    1995-01-12

    We investigate the possibility that gauginos are massless at tree level and that the U(1) R-invariance is broken spontaneously by Higgs vevs, like the chiral symmetry of quarks in the standard model, or else explicitly by dimension 2 or 3 SUSY-breaking terms in the low energy effective Lagrangian. Gluino and lightest neutralino masses then depend on only a few parameters. For a SUSY-breaking scale <~ 400 GeV, the gluino and lightest neutralino have masses typically in the range 1/10 ~ 2 1/2 GeV. On the other hand, for a SUSY-breaking scale several TeV or larger, radiative contributions can yield gluino and lightest neutralino masses of O(50-300) GeV and O(10-30) GeV, respectively. As long as the Higgs vev is the only source of R-invariance breaking, or if SUSY breaking only appears in dimension 2 terms in the effective Lagrangian, the gluino is generically the lightest SUSY particle, modifying the usual phenomenology in interesting ways.

  6. Radiation detection system

    DOE Patents [OSTI]

    Riedel, Richard A. (Knoxville, TN); Wintenberg, Alan L. (Knoxville, TN); Clonts, Lloyd G. (Knoxville, TN); Cooper, Ronald G. (Oak Ridge, TN)

    2012-02-14

    A preamplifier circuit for processing a signal provided by a radiation detector includes a transimpedance amplifier coupled to receive a current signal from a detector and generate a voltage signal at its output. A second amplification stage has an input coupled to an output of the transimpedance amplifier for providing an amplified voltage signal. Detector electronics include a preamplifier circuit having a first and second transimpedance amplifier coupled to receive a current signal from a first and second location on a detector, respectively, and generate a first and second voltage signal at respective outputs. A second amplification stage has an input coupled to an output of the transimpedance amplifiers for amplifying the first and said second voltage signals to provide first and second amplified voltage signals. A differential output stage is coupled to the second amplification stage for receiving the first and second amplified voltage signals and providing a pair of outputs from each of the first and second amplified voltage signals. Read out circuitry has an input coupled to receive both of the pair of outputs, the read out circuitry having structure for processing each of the pair of outputs, and providing a single digital output having a time-stamp therefrom.

  7. 10 CFR 835- Occupational Radiation Protection

    Broader source: Energy.gov [DOE]

    The rules in this part establish radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of DOE activities.

  8. Annual DOE Occupational Radiation Exposure | 1974 Report

    Broader source: Energy.gov [DOE]

    The Seventh Annual Report of Radiation Exposures for AEC & AEC Contractor Employees analyzes occupational radiation exposures at the Atomic Energy Commission (AEC) and its contractor employees during 1974.

  9. Metamaterials - new opportunity in manipulating terahertz radiation...

    Office of Scientific and Technical Information (OSTI)

    Metamaterials - new opportunity in manipulating terahertz radiation Citation Details In-Document Search Title: Metamaterials - new opportunity in manipulating terahertz radiation...

  10. Radiation-thermoacoustic microscopy of condensed media

    SciTech Connect (OSTI)

    Lyamshev, L.M.; Chelnokov, B.I.

    1984-07-01

    Possibilities are discussed for the application of scanning radiation-thermoacoustic microscopy, using different types of radiation, for microstructure analysis. (AIP)

  11. Standards for Protection Against Radiation (Michigan)

    Broader source: Energy.gov [DOE]

    This rule establishes standards for protection against radiation hazards. In addition to complying with requirements set forth, every reasonable effort should be made to maintain radiation levels...

  12. INSTRUMENTATION, INCLUDING NUCLEAR AND PARTICLE DETECTORS; RADIATION

    Office of Scientific and Technical Information (OSTI)

    interval technical basis document Chiaro, P.J. Jr. 44 INSTRUMENTATION, INCLUDING NUCLEAR AND PARTICLE DETECTORS; RADIATION DETECTORS; RADIATION MONITORS; DOSEMETERS;...

  13. Occupational Radiation Exposure | Department of Energy

    Office of Environmental Management (EM)

    Exposure Monitoring Systems (REMS) Radiation Exposure Monitoring System (REMS) is the database of occupational radiation exposures for all monitored DOE employees, contractors,...

  14. Purification, crystallization and preliminary X-ray diffraction analysis of the kinase domain of human tousled-like kinase 2

    SciTech Connect (OSTI)

    Garrote, Ana M.; Redondo, Pilar; Montoya, Guillermo; Muńoz, Inés G.

    2014-02-19

    The C-terminal kinase domain of TLK2 (a human tousled-like kinase) has been cloned and overexpressed in Escherichia coli followed by purification to homogeneity. Crystallization experiments in the presence of ATP-?-S yielded crystals suitable for X-ray diffraction analysis belonging to two different space groups: tetragonal I4{sub 1}22 and cubic P2{sub 1}3. Tousled-like kinases (TLKs) are an evolutionarily conserved family of serine/threonine protein kinases involved in chromatin dynamics, including DNA replication and repair, transcription and chromosome segregation. The two members of the family reported in humans, namely TLK1 and TLK2, localize to the cell nucleus and are capable of forming homo- or hetero-oligomers by themselves. To characterize the role of TLK2, its C-terminal kinase domain was cloned and overexpressed in Escherichia coli followed by purification to homogeneity. Crystallization experiments in the presence of ATP-?-S yielded crystals suitable for X-ray diffraction analysis belonging to two different space groups: tetragonal I4{sub 1}22 and cubic P2{sub 1}3. The latter produced the best diffracting crystal (3.4 Ĺ resolution using synchrotron radiation), with unit-cell parameters a = b = c = 126.05 Ĺ, ? = ? = ? = 90°. The asymmetric unit contained one protein molecule, with a Matthews coefficient of 4.59 Ĺ{sup 3} Da{sup ?1} and a solvent content of 73.23%.

  15. Actively driven thermal radiation shield

    DOE Patents [OSTI]

    Madden, Norman W. (Livermore, CA); Cork, Christopher P. (Pleasant Hill, CA); Becker, John A. (Alameda, CA); Knapp, David A. (Livermore, CA)

    2002-01-01

    A thermal radiation shield for cooled portable gamma-ray spectrometers. The thermal radiation shield is located intermediate the vacuum enclosure and detector enclosure, is actively driven, and is useful in reducing the heat load to mechanical cooler and additionally extends the lifetime of the mechanical cooler. The thermal shield is electrically-powered and is particularly useful for portable solid-state gamma-ray detectors or spectrometers that dramatically reduces the cooling power requirements. For example, the operating shield at 260K (40K below room temperature) will decrease the thermal radiation load to the detector by 50%, which makes possible portable battery operation for a mechanically cooled Ge spectrometer.

  16. Ultraviolet radiation induced discharge laser

    DOE Patents [OSTI]

    Gilson, Verle A. (Livermore, CA); Schriever, Richard L. (Livermore, CA); Shearer, James W. (Livermore, CA)

    1978-01-01

    An ultraviolet radiation source associated with a suitable cathode-anode electrode structure, disposed in a gas-filled cavity of a high pressure pulsed laser, such as a transverse electric atmosphere (TEA) laser, to achieve free electron production in the gas by photoelectric interaction between ultraviolet radiation and the cathode prior to the gas-exciting cathode-to-anode electrical discharge, thereby providing volume ionization of the gas. The ultraviolet radiation is produced by a light source or by a spark discharge.

  17. Simulation of radiation-induced defects

    E-Print Network [OSTI]

    Timo Peltola

    2015-09-29

    Mainly due to their outstanding performance the position sensitive silicon detectors are widely used in the tracking systems of High Energy Physics experiments such as the ALICE, ATLAS, CMS and LHCb at LHC, the world's largest particle physics accelerator at CERN, Geneva. The foreseen upgrade of the LHC to its high luminosity (HL) phase (HL-LHC scheduled for 2023), will enable the use of maximal physics potential of the facility. After 10 years of operation the expected fluence will expose the tracking systems at HL-LHC to a radiation environment that is beyond the capacity of the present system design. Thus, for the required upgrade of the all-silicon central trackers extensive measurements and simulation studies for silicon sensors of different designs and materials with sufficient radiation tolerance have been initiated within the RD50 Collaboration. Supplementing measurements, simulations are in vital role for e.g. device structure optimization or predicting the electric fields and trapping in the silicon sensors. The main objective of the device simulations in the RD50 Collaboration is to develop an approach to model and predict the performance of the irradiated silicon detectors using professional software. The first successfully developed quantitative models for radiation damage, based on two effective midgap levels, are able to reproduce the experimentally observed detector characteristics like leakage current, full depletion voltage and charge collection efficiency (CCE). Recent implementations of additional traps at the SiO$_2$/Si interface or close to it have expanded the scope of the experimentally agreeing simulations to such surface properties as the interstrip resistance and capacitance, and the position dependency of CCE for strip sensors irradiated up to $\\sim$$1.5\\times10^{15}$ n$_{\\textrm{eq}}\\textrm{cm}^{-2}$.

  18. Cloud water contents and hydrometeor sizes during the FIRE Arctic Clouds Experiment

    E-Print Network [OSTI]

    Shupe, Matthew

    Cloud water contents and hydrometeor sizes during the FIRE Arctic Clouds Experiment Matthew D a 35-GHz cloud radar and the DOE Atmospheric Radiation Measurement Program operated a suite Clouds Experiment took place during April­July 1998, with the primary goal of investigating cloud

  19. General relativity and experiment

    E-Print Network [OSTI]

    T. Damour

    1994-12-08

    The confrontation between Einstein's theory of gravitation and experiment is summarized. Although all current experimental data are compatible with general relativity, the importance of pursuing the quest for possible deviations from Einstein's theory is emphasized.

  20. Experiment Scheduling Committee

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Experiment Scheduling Committee Title Name Phome Email Deputy Director for Research Bob McKeown (757) 269-6481 bmck@jlab.org Physics Division AD (co-chair) Rolf Ent (757) 269-7373...