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1

Persistence of gamma-H2AX and 53BP1 foci in proliferating and nonproliferating human mammary epithelial cells after exposure to gamma-rays or iron ions  

SciTech Connect

To investigate {gamma}-H2AX (phosphorylated histone H2AX) and 53BP1 (tumour protein 53 binding protein No. 1) foci formation and removal in proliferating and non-proliferating human mammary epithelial cells (HMEC) after exposure to sparsely and densely ionizing radiation under different cell culture conditions. HMEC cells were grown either as monolayers (2D) or in extracellular matrix to allow the formation of acinar structures in vitro (3D). Foci numbers were quantified by image analysis at various time points after exposure. Our results reveal that in non-proliferating cells under 2D and 3D cell culture conditions, iron-ion induced {gamma}-H2AX foci were still present at 72 h after exposure, although 53BP1 foci returned to control levels at 48 h. In contrast in proliferating HMEC, both {gamma}-H2AX and 53BP1 foci decreased to control levels during the 24-48 h time interval after irradiation under 2D conditions. Foci numbers decreased faster after {gamma}-ray irradiation and returned to control levels by 12 h regardless of marker, cell proliferation status, and cell culture condition. Conclusions: The disappearance of radiation induced {gamma}-H2AX and 53BP1 foci in HMEC have different dynamics that depend on radiation quality and proliferation status. Notably, the general patterns do not depend on the cell culture condition (2D versus 3D). We speculate that the persistent {gamma}-H2AX foci in iron-ion irradiated non-proliferating cells could be due to limited availability of double strand break (DSB) repair pathways in G0/G1-phase, or that repair of complex DSB requires replication or chromatin remodeling.

Groesser, Torsten; Chang, Hang; Fontenay, Gerald; Chen, James; Costes, Sylvain V.; Barcellos-Hoff, Mary Helen; Parvin, Bahram; Rydberg, Bjorn

2010-12-22T23:59:59.000Z

2

EGF-receptor phosphorylation and downstream signaling are activated by benzo[a]pyrene 3,6-quinone and benzo[a]pyrene 1,6-quinone in human mammary epithelial cells  

SciTech Connect

Benzo[a]pyrene (BaP) is activated by xenobiotic-metabolizing enzymes to highly mutagenic and carcinogenic metabolites. Previous studies in this laboratory have shown that benzo[a]pyrene quinones (BPQs), 1,6-BPQ and 3,6-BPQ, are able to induce epidermal growth factor receptor (EGFR) cell signaling through the production of reactive oxygen species. Recently, we have reported that BPQs have the potential to induce the expression of genes involved in numerous pathways associated with cell proliferation and survival in human mammary epithelial cells. In the present study we demonstrated that BPQs not only induced EGFR tyrosine autophosphorylation, but also induced EGFR-dependent tyrosine phosphorylation of phospholipase C-{gamma}1 and several signal transducers and activators of transcription (STATs). The effects of BPQs were evaluated in a model of EGF withdrawal in MCF10-A cells. We found that BPQs (1 {mu}M), induced EGFR tyrosine phosphorylation at positions Y845, Y992, Y1068, and Y1086. PLC-{gamma}1 phosphorylation correlated with the phosphorylation of tyrosine-Y992, a proposed docking site for PLC-{gamma}1 on the EGFR. Additionally, we found that BPQs induced the activation of STAT-1, STAT-3, STAT-5a and STAT-5b. STAT5 was shown to translocate to the nucleus following 3,6-BPQ and 1,6-BPQ exposures. Although the patterns of phosphorylation at EGFR, PLC-{gamma}1 and STATs were quite similar to those induced by EGF, an important difference between BPQ-mediated signaling of the EGFR was observed. Signaling produced by EGF ligand produced a rapid disappearance of EGFR from the cell surface, whereas BPQ signaling maintained EGFR receptors on the cell membrane. Thus, the results of these studies show that 1,6-BPQ and 3,6-BPQ can produce early events as evidenced by EGFR expression, and a prolonged transactivation of EGFR leading to downstream cell signaling pathways.

Rodriguez-Fragoso, Lourdes [Facultad de Farmacia, Universidad Autonoma del Estado de Morelos, Avenida Universidad 1001 Col. Chamilpa, Cuernavaca 62210, Morelos (Mexico); Melendez, Karla; Hudson, Laurie G.; Lauer, Fredine T. [University of New Mexico, College of Pharmacy Toxicology Program, Albuquerque, New Mexico (United States); Burchiel, Scott W. [University of New Mexico, College of Pharmacy Toxicology Program, Albuquerque, New Mexico (United States)], E-mail: sburchiel@salud.unm.edu

2009-03-15T23:59:59.000Z

3

Milk lipid and protein traffic in mammary epithelial cells: joint and independent pathways  

E-Print Network (OSTI)

of prolactin and oxytocin on lipid and protein secretion suggest that these processes are coupled and co is not strictly required. milk lipids / mammary epithelial cells / secretion Résumé -- Transport des lipides et biologists, dairy scientists and technologists: Are the intracellular secretion processes of lipids

Boyer, Edmond

4

Effects of Dietary Energy Restriction on Gene Regulation in Mammary Epithelial Cells  

Science Journals Connector (OSTI)

...Article Prevention Effects of Dietary Energy Restriction on Gene Regulation in Mammary...study was to determine whether dietary energy restriction (DER) affects the pattern of gene expression in three interrelated energy metabolism pathways: glycolysis, gluconeogenesis...

Zongjian Zhu; Weiqin Jiang; John N. McGinley; Jennifer M. Price; Bifeng Gao; Henry J. Thompson

2007-12-15T23:59:59.000Z

5

Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion  

Science Journals Connector (OSTI)

...polyvinyl pyrrolidone and then hybridized with 32P-labeled, nick-translated mouse caseins or whey acidic protein (WAP) cDNA...matrix of mammary cells (29) to that of casein gene expression merit further investigation. We thank Dr. Jeffrey M. Rosen for...

E Y Lee; W H Lee; C S Kaetzel; G Parry; M J Bissell

1985-01-01T23:59:59.000Z

6

Human Mammary Luminal Epithelial Cells Contain Progenitors to Myoepithelial Cells  

E-Print Network (OSTI)

18 and 19 (K18K19), vimentin (vim) and ?-sm actin (ASMA) inDako), and vimentin (VIM; MEDAC, GmbH). Other antibodiesa mAb against vimentin (VIM, IgG1). The secondary antibodies

Pechoux, Christine

2010-01-01T23:59:59.000Z

7

Disrupted epithelial morphogenesis and aberrant lineage commitment  

NLE Websites -- All DOE Office Websites (Extended Search)

Disrupted epithelial morphogenesis and aberrant lineage commitment Disrupted epithelial morphogenesis and aberrant lineage commitment following radiation and TGFβ I. Fernandez-Garcia New York University School of Medicine Abstract In the present study, we evaluated cell lineage plasticity and its phenotypic effects in the non-malignant human mammary epithelial cell line MCF10A in response to ionizing radiation and TGFΒ. We have recently shown that the molecular profiles of mammary tumors and normal mammary gland from irradiated mice are distinct from those arising in unirradiated mice by virtue of enriched stem cell and progenitor markers. Consistent with this, we found that radiation (10-100 cGy) increases the mammary repopulation capacity in a functional and marker assays (Nguyen et al. Cancer Cell 2011). Some studies have shown that epithelial-mesenchymal transition (EMT)

8

Low Dose Radiation Research Program: The Progeny of Irradiated Mammary  

NLE Websites -- All DOE Office Websites (Extended Search)

Progeny of Irradiated Mammary Epithelial Cells Exhibit a Phenotype Progeny of Irradiated Mammary Epithelial Cells Exhibit a Phenotype Characteristic of Malignancy Mary H. Barcellos-Hoff, R.L. Henshall-Powell, M.J. Bissell, and B. Parvin Lawrence Berkeley National Laboratory, Life Sciences Division We have proposed that the ability of radiation to induce altered microenvironments affects the frequency and features of neoplastic progression. Thus, we have sought to characterize the irradiated microenvironment and determine how these events contribute to mammary carcinogenesis. By using imaging bioinformatics to analyze mouse and human models of breast cancer we have now examined cell adhesion molecules (CAMs) critical for tissue-specific organization and function. We found that 1) radiation-induced microenvironments can contribute to neoplastic potential

9

Gene expression analysis of human primary prostate epithelial and  

NLE Websites -- All DOE Office Websites (Extended Search)

expression analysis of human primary prostate epithelial and expression analysis of human primary prostate epithelial and fibroblast cell cultures to an acute dose of 10cGy J. Tyson McDonald Steward St. Elizabeth’s Medical Center Abstract Primary tissue represents a better model for studies than immortalized cell lines that are adapted to culture conditions and may no longer reflect a realistic biological state. In this study, normal tissues from clinically indicated robotic-assisted laparoscopic radical prostatectomy were grossly identified, sectioned into frozen or formalin fixed samples, and processed as primary cultures. Normal epithelial and fibroblast primary cell cultures were derived from regions of normal tissue, as confirmed by analysis on adjacent tissue by hematoxylin and eosin staining, were exposed to acute

10

Airway epithelial cell response to human metapneumovirus infection  

SciTech Connect

Human metapneumovirus (hMPV) is a major cause of lower respiratory tract infections (LRTIs) in infants, elderly and immunocompromised patients. In this study, we show that hMPV can infect in a similar manner epithelial cells representative of different tracts of the airways. hMPV-induced expression of chemokines IL-8 and RANTES in primary small alveolar epithelial cells (SAE) and in a human alveolar type II-like epithelial cell line (A549) was similar, suggesting that A549 cells can be used as a model to study lower airway epithelial cell responses to hMPV infection. A549 secreted a variety of CXC and CC chemokines, cytokines and type I interferons, following hMPV infection. hMPV was also a strong inducer of transcription factors belonging to nuclear factor (NF)-{kappa}B, interferon regulatory factors (IRFs) and signal transducers and activators of transcription (STATs) families, which are known to orchestrate the expression of inflammatory and immunomodulatory mediators.

Bao, X.; Liu, T.; Spetch, L.; Kolli, D. [Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas (United States); Garofalo, R.P. [Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas (United States); Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas (United States); Casola, A. [Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas (United States); Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas (United States)], E-mail: ancasola@utmb.edu

2007-11-10T23:59:59.000Z

11

Carcinoma Induction following Direct in Situ Transfer of v-Ha-ras into Rat Mammary Epithelial Cells Using Replication-defective Retrovirus Vectors  

Science Journals Connector (OSTI)

...observed for chemically induced mammary car- cinogenesis (27, 28). Most of the...DISCUSSION We have established a replication-defective retrovirus vector- mediated gene transfer...Furthermore, as in chemically induced car cinomas, the frequency of mammary tumor...

Bingcheng Wang; Wendy S. Kennan; Jane Yasukawa-Barnes; Mary J. Lindstrom; and Michael N. Gould

1991-05-15T23:59:59.000Z

12

Disrupted epithelial morphogenesis and aberrant lineage commitment following radiation and TGFβ  

NLE Websites -- All DOE Office Websites (Extended Search)

Disrupted epithelial morphogenesis and aberrant lineage Disrupted epithelial morphogenesis and aberrant lineage commitment following radiation and TGFβ I. Fernandez-Garcia and M.H. Barcellos-Hoff Department of Radiation Oncology, New York University School of Medicine, NY. In the present study, we evaluated cell lineage plasticity and its phenotypic effects in the non-malignant human mammary epithelial cell line MCF10A in response to ionizing radiation and TGFβ. We have recently shown that the molecular profiles of mammary tumors and normal mammary gland from irradiated mice are distinct from those arising in unirradiated mice by virtue of enriched stem cell and progenitor markers. Consistent with this, we found that radiation (10-100 cGy) increases the mammary repopulation capacity in a functional and marker assays (Nguyen et al. Cancer Cell

13

Morphological and Histological Characteristics of Mammary Dysplasias Occurring in Cell Dissociation-derived Murine Mammary Outgrowths  

Science Journals Connector (OSTI)

...Smithville, Texas 78957 [L. M. A.]; and Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830 [R. L U.] ABSTRACT The morphological...mammary carcinoma in humans. Wellings and co-workers (17,18) have classified human mammary lesions...

Stephen P. Ethier; Laurel M. Adams; and Robert L. Ullrich

1984-10-01T23:59:59.000Z

14

Regulation of Mammary Lactogenic Differentiation by Singleminded-2s  

E-Print Network (OSTI)

juvenile gland showing TEB structures. H. WM mature mammary gland. I, WM mammary gland at pregnancy day 10. J, WM mammary gland during lactation. 3 Studies performed in mice lacking ESR1, ESR2, Pgr, GHR, or PrlR revealed that embryonic... tumor necrosis factor (TNF) ligand superfamily member, and its receptor, EdaR, are expressed in the mesenchyme and epithelial placode cells, respectively (Pispa et al. 2003). Overexpression of Eda in mice results in supernumerary and enlarged mammary...

Wellberg, Elizabeth

2010-07-14T23:59:59.000Z

15

Genetic susceptibility to low-dose ionizing radiation in the mouse mammary glandas a means of understanding human risk for breast cancer  

NLE Websites -- All DOE Office Websites (Extended Search)

susceptibility to low-dose ionizing radiation in the mouse mammary gland susceptibility to low-dose ionizing radiation in the mouse mammary gland as a means of understanding human risk for breast cancer Antoine M. Snijders 1 , Francesco Marchetti 1 , Ju Han 1 , Sandhya Bhatnagar 1 , Nadire Duru 1 , Zhi Hu 1 , Jian-Hua Mao 1 , Mina Bissell 1 , Joe Gray 1,2 , Gary H. Karpen 1 , Priscilla K. Cooper 1 and Andrew J. Wyrobek 1 1 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 2 Current affiliation: Biomedical Engineering, Oregon Health Science Univ, Portland, OR Goal: Our goal is to develop an in vivo mechanistic model of genetic variation in the low-dose damage responses of mammary glands using inbred mice known to vary in their sensitivity to low-dose induced mammary gland cancer, and to develop molecular predictors for susceptibility or resistance to low-dose induced breast cancer.

16

Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation  

SciTech Connect

Cellular senescence suppresses cancer by arresting cells at risk for malignant tumorigenesis. However, senescent cells also secrete molecules that can stimulate premalignant cells to proliferate and form tumors, suggesting the senescence response is antagonistically pleiotropic. We show that premalignant mammary epithelial cells exposed to senescent human fibroblasts in mice irreversibly lose differentiated properties, become invasive and undergo full malignant transformation. Moreover, using cultured mouse or human fibroblasts and non-malignant breast epithelial cells, we show that senescent fibroblasts disrupt epithelial alveolar morphogenesis, functional differentiation, and branching morphogenesis. Further, we identify MMP-3 as the major factor responsible for the effects of senescent fibroblasts on branching morphogenesis. Our findings support the idea that senescent cells contribute to age-related pathology, including cancer, and describe a new property of senescent fibroblasts--the ability to alter epithelial differentiation--that might also explain the loss of tissue function and organization that is a hallmark of aging.

Parrinello, Simona; Coppe, Jean-Philippe; Krtolica, Ana; Campisi, Judith

2004-07-14T23:59:59.000Z

17

Human internal mammary artery contraction by isoprostaglandin F2? type-III (8-iso-prostaglandin F2?)  

Science Journals Connector (OSTI)

Isoprostaglandin F2? type-III (formerly known as 8-iso-prostaglandin F2?) is produced in large quantities in vivo in clinical situations associated with oxidant stress such as atherosclerosis, hypercholesterolemia, and myocardial reperfusion. Isoprostaglandin F2? type-III may alter smooth muscle and platelet functions. The aim of this study was to evaluate the effects of isoprostaglandin F2? type-III on isolated human internal mammary arteries, and to characterise the signalling underlying mechanisms. In organ baths, concentration-dependent contractions of human internal mammary arteries were obtained in response to isoprostaglandin F2? type-III stimulation. The responses to isoprostaglandin F2? type-III were inhibited in a concentration-dependent manner by the thromboxane A2 receptor antagonist, GR 32191 ([1R-[1 ?(Z), 2?,3?,5 ?(+)-7-[[1,1?-biphenyl)-4-yl]methoxy]-3-hydroxy-2-(1-piperidinyl) cyclo pentyl]-4-4heptanoic acid], hydrochloride), 310?9 to 310?7 M). However, this effect was associated with a decreased maximal contraction. AH 6809 (6-isopropoxy-9-oxoxanthene-2-carboxylic acid, 10?6 to 310?5 M), an EP1-DP receptor antagonist had no effect on isoprostaglandin F2? type-III-induced contractions. The maximal responses to isoprostaglandin F2? type-III were significantly reduced in the presence of the cyclooxygenase inhibitor indomethacin (10?5 M) (Emax: 14720% vs. 21319% in control group, PTP receptor but not EP1-DP-receptor activation, (3) thromboxane A2 but not cysteinyl leukotrienes production is involved in the vascular effects of isoprostaglandin F2? type-III. Isoprostaglandin F2? type-III, produced at sites of free radical generation, may play an important role in internal mammary artery spasm in situations of oxidant stress such as coronary bypass surgery.

Jean-Luc Cracowski; Franoise Stanke-Labesque; Philippe Devillier; Olivier Chavanon; Mark Hunt; Claude Souvignet; Germain Bessard

2000-01-01T23:59:59.000Z

18

The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion  

SciTech Connect

The human breast comprises three lineages: the luminal epithelial lineage, the myoepithelial lineage, and the mesenchymal lineage. It has been widely accepted that human breast neoplasia pertains only to the luminal epithelial lineage. In recent years, however, evidence has accumulated that neoplastic breast epithelial cells may be substantially more plastic in their differentiation repertoire than previously anticipated. Thus, along with an increasing availability of markers for the myoepithelial lineage, at least a partial differentiation towards this lineage is being revealed frequently. It has also become clear that conversions towards the mesenchymal lineage actually occur, referred to as epithelial to mesenchymal transitions. Indeed, some of the so-called myofibroblasts surrounding the tumor may indeed have an epithelial origin rather than a mesenchymal origin. Because myoepithelial cells, epithelial to mesenchymal transition-derived cells, genuine stromal cells and myofibroblasts share common markers, we now need to define a more ambitious set of markers to distinguish these cell types in the microenvironment of the tumors. This is necessary because the different microenvironments may confer different clinical outcomes. The aim of this commentary is to describe some of the inherent complexities in defining cellular phenotypes in the microenvironment of breast cancer and to expand wherever possible on the implications for tumor suppression and progression.

Petersen, Ole William; Nielsen, Helga Lind; Gudjonsson, Thorarinn; Villadsen, Ren& #233; Ronnov-Jessen, Lone; Bissell, Mina J.

2001-05-12T23:59:59.000Z

19

Hepatocyte Growth Factor and Neuregulin in Mammary Gland Cell Morphogenesis  

Science Journals Connector (OSTI)

Organ culture and transplantation experiments in the early 1960s and 1970s have demonstrated that growth and morphogenesis of the epithelium of the mammary gland are controlled by mesenchymal-epithelial intera...

Catherin Niemann; 1; 2Volker Brinkmann; Walter Birchmeier

2002-01-01T23:59:59.000Z

20

Particulate depleted uranium is cytotoxic and clastogenic to human lung epithelial cells  

Science Journals Connector (OSTI)

Depleted uranium (DU) is commonly used in military applications and consequently exposure to soldiers and non-combatants is potentially frequent and widespread. DU is suspected to be a carcinogen, potentially affecting the bronchial cells of the lung. Few studies have considered DU in human bronchial cells. Accordingly, we determined the cytotoxicity and clastogenicity of particulate DU in human bronchial epithelial cells (BEP2D cells). DU-induced concentration-dependent cytotoxicity in human bronchial epithelial cells, and was not clastogenic after 24h but induced chromosomal aberrations after 48h. These data indicate that if DU is a human bronchial carcinogen, it is likely acting through a mechanism that involves DNA breaks after longer exposures.

Carolyne LaCerte; Hong Xie; AbouEl-Makarim Aboueissa; John Pierce Wise Sr.

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells  

SciTech Connect

Substantial evidence indicates that exposure to bisphenol A (BPA) during early development may increase breast cancer risk later in life. The changes may persist into puberty and adulthood, suggesting an epigenetic process being imposed in differentiated breast epithelial cells. The molecular mechanisms by which early memory of BPA exposure is imprinted in breast progenitor cells and then passed onto their epithelial progeny are not well understood. The aim of this study was to examine epigenetic changes in breast epithelial cells treated with low-dose BPA. We also investigated the effect of BPA on the ER{alpha} signaling pathway and global gene expression profiles. Compared to control cells, nuclear internalization of ER{alpha} was observed in epithelial cells preexposed to BPA. We identified 170 genes with similar expression changes in response to BPA. Functional analysis confirms that gene suppression was mediated in part through an ER{alpha}-dependent pathway. As a result of exposure to BPA or other estrogen-like chemicals, the expression of lysosomal-associated membrane protein 3 (LAMP3) became epigenetically silenced in breast epithelial cells. Furthermore, increased DNA methylation in the LAMP3 CpG island was this repressive mark preferentially occurred in ER{alpha}-positive breast tumors. These results suggest that the in vitro system developed in our laboratory is a valuable tool for exposure studies of BPA and other xenoestrogens in human cells. Individual and geographical differences may contribute to altered patterns of gene expression and DNA methylation in susceptible loci. Combination of our exposure model with epigenetic analysis and other biochemical assays can give insight into the heritable effect of low-dose BPA in human cells.

Weng, Yu-I; Hsu, Pei-Yin; Liyanarachchi, Sandya; Liu, Joseph; Deatherage, Daniel E.; Huang Yiwen; Zuo Tao; Rodriguez, Benjamin [Human Cancer Genetics Program, Ohio State University, Columbus, OH 43210 (United States); Lin, Ching-Hung; Cheng, Ann-Lii [Department of Internal Medicine and Oncology, National Taiwan University Hospital, Taipei, Taiwan (China); Huang, Tim H.-M., E-mail: Tim.Huang@osumc.ed [Human Cancer Genetics Program, Ohio State University, Columbus, OH 43210 (United States)

2010-10-15T23:59:59.000Z

22

Association of Decreased Intercellular Communication with the Immortal but not the Tumorigenic Phenotype in Human Mammary Epithelial Cells  

Science Journals Connector (OSTI)

...per 100-mm dish were plated in medium containing 30 /J.MTG. After 3 wk, the plates were stained and TG' colonies containing...observed in the two cell lines is a function of the immortalization process. Previous observations using a variety of techniques to show...

Sandra R. Eldridge; Thomas W. Martens; Carol A. Sattler; and Michael N. Gould

1989-08-01T23:59:59.000Z

23

Pim-1 kinase expression during murine mammary development  

SciTech Connect

Pim-1 kinase phosphorylates substrates whose activities are linked to proliferation, survival, differentiation, and apoptosis. Although pim-1 is induced by hormones and cytokines, the hormonal control and contribution of Pim-1 to mammary gland development have not been evaluated. We examined Pim-1 expression in mammary cell lines, investigated whether Pim-1 levels could be altered in breast epithelia by mammogenic hormones, and evaluated Pim-1 expression during mammary development. We found that Pim-1 was elevated in most mammary carcinoma cell lines and progesterone increased Pim-1 protein to some extent in non-tumorigenic mammary epithelia. Pim-1 expression in situ was consistent with the documented profile of progesterone activity in mouse mammary glands. Pim-1 nuclear localization correlated with cytoplasmic distribution for its substrate, p21{sup CIP/Waf1}, and we found that Pim-1 and p21 associate in vitro. Our results suggest that Pim-1 expression may be regulated by progesterone during mammary development and Pim-1 associates with p21 in mammary epithelial cells.

Gapter, Leslie A. [Department of Pharmacy, Faculty of Science, National University of Singapore, 117543 (Singapore); School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4234 (United States); Magnuson, Nancy S. [School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4234 (United States); Ng, Ka-yun [Department of Pharmacy, Faculty of Science, National University of Singapore, 117543 (Singapore); Hosick, Howard L. [School of Molecular Biosciences, Washington State University, Pullman, WA 99164-4234 (United States)]. E-mail: hosick@wsu.edu

2006-07-07T23:59:59.000Z

24

Identification of human metapneumovirus-induced gene networks in airway epithelial cells by microarray analysis  

SciTech Connect

Human metapneumovirus (hMPV) is a major cause of lower respiratory tract infections in infants, elderly and immunocompromised patients. Little is known about the response to hMPV infection of airway epithelial cells, which play a pivotal role in initiating and shaping innate and adaptive immune responses. In this study, we analyzed the transcriptional profiles of airway epithelial cells infected with hMPV using high-density oligonucleotide microarrays. Of the 47,400 transcripts and variants represented on the Affimetrix GeneChip Human Genome HG-U133 plus 2 array, 1601 genes were significantly altered following hMPV infection. Altered genes were then assigned to functional categories and mapped to signaling pathways. Many up-regulated genes are involved in the initiation of pro-inflammatory and antiviral immune responses, including chemokines, cytokines, type I interferon and interferon-inducible proteins. Other important functional classes up-regulated by hMPV infection include cellular signaling, gene transcription and apoptosis. Notably, genes associated with antioxidant and membrane transport activity, several metabolic pathways and cell proliferation were down-regulated in response to hMPV infection. Real-time PCR and Western blot assays were used to confirm the expression of genes related to several of these functional groups. The overall result of this study provides novel information on host gene expression upon infection with hMPV and also serves as a foundation for future investigations of genes and pathways involved in the pathogenesis of this important viral infection. Furthermore, it can facilitate a comparative analysis of other paramyxoviral infections to determine the transcriptional changes that are conserved versus the one that are specific to individual pathogens.

Bao, X. [Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas (United States); Sinha, M. [Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas (United States)]|[UTMB Bioinformatics Program, University of Texas Medical Branch, Galveston, Texas (United States); Liu, T.; Hong, C. [Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas (United States); Luxon, B.A. [Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas (United States)]|[UTMB Bioinformatics Program, University of Texas Medical Branch, Galveston, Texas (United States); Garofalo, R.P. [Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas (United States)]|[Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas (United States)]|[Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas (United States); Casola, A. [Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas (United States)]|[Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas (United States)]|[Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas (United States)], E-mail: ancasola@utmb.edu

2008-04-25T23:59:59.000Z

25

Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells  

SciTech Connect

Mouse mammary tumor virus (MMTV) is a pH-dependent virus that uses mouse transferrin receptor 1 (TfR1) for entry into cells. Previous studies demonstrated that MMTV could induce pH 5-dependent fusion-from-with of mouse cells. Here we show that the MMTV envelope-mediated cell-cell fusion requires both the entry receptor and low pH (pH 5). Although expression of the MMTV envelope and TfR1 was sufficient to mediate low pH-dependent syncytia formation, virus infection required trafficking to a low pH compartment; infection was independent of cathepsin-mediated proteolysis. Human TfR1 did not support virus infection, although envelope-mediated syncytia formation occurred with human cells after pH 5 treatment and this fusion depended on TfR1 expression. However, although the MMTV envelope bound human TfR1, virus was only internalized and trafficked to a low pH compartment in cells expressing mouse TfR1. Thus, while human TfR1 supported cell-cell fusion, because it was not internalized when bound to MMTV, it did not function as an entry receptor. Our data suggest that MMTV uses TfR1 for all steps of entry: cell attachment, induction of the conformational changes in Env required for membrane fusion and internalization to an appropriate acidic compartment.

Wang Enxiu; Obeng-Adjei, Nyamekye; Ying Qihua [Department of Microbiology and Abramson Family Cancer Center, University of Pennsylvania, 313BRBII/III, 421 Curie Blvd., Philadelphia, PA 19104 (United States); Meertens, Laurent; Dragic, Tanya [Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY (United States); Davey, Robert A. [Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX (United States); Ross, Susan R. [Department of Microbiology and Abramson Family Cancer Center, University of Pennsylvania, 313BRBII/III, 421 Curie Blvd., Philadelphia, PA 19104 (United States)], E-mail: rosss@mail.med.upenn.edu

2008-11-25T23:59:59.000Z

26

Continuous human cell lines and method of making same  

DOE Patents (OSTI)

Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo(a)pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors. 2 tabs.

Stampfer, M.R.

1985-07-01T23:59:59.000Z

27

Continuous human cell lines and method of making same  

DOE Patents (OSTI)

Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo[a]pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors.

Stampfer, Martha R. (Oakland, CA)

1989-01-01T23:59:59.000Z

28

Radiation Induced Mammary Cancer  

Science Journals Connector (OSTI)

......Induced Mammary Cancer R.L. Ullrich * R.J. Preston # * Department of Radiation Therapy, University of Texas Medical Branch, Galveston, TX 77550 # Biology Division Oak Ridge National Laboratory Oak Ridge, TN 37831, U.S.A Over the last......

R.L. Ullrich; R.J. Preston

1991-12-01T23:59:59.000Z

29

Of Microenvironments and Mammary Stem Cells  

SciTech Connect

In most adult tissues there reside pools of stem and progenitor cells inside specialized microenvironments referred to as niches. The niche protects the stem cells from inappropriate expansion and directs their critical functions. Thus guided, stem cells are able to maintain tissue homeostasis throughout the ebb and flow of metabolic and physical demands encountered over a lifetime. Indeed, a pool of stem cells maintains mammary gland structure throughout development, and responds to the physiological demands associated with pregnancy. This review discusses how stem cells were identified in both human and mouse mammary glands; each requiring different techniques that were determined by differing biological needs and ethical constraints. These studies together create a robust portrait of mammary gland biology and identify the location of the stem cell niche, elucidate a developmental hierarchy, and suggest how the niche might be manipulated for therapeutic benefit.

LaBarge, Mark A; Petersen, Ole W; Bissell, Mina J

2007-06-01T23:59:59.000Z

30

The low dose damage response pathways in the mouse mammary glands depends  

NLE Websites -- All DOE Office Websites (Extended Search)

low dose damage response pathways in the mouse mammary glands depends low dose damage response pathways in the mouse mammary glands depends on genotype, tissue compartment, exposure regimen, and sampling times Joe Gray & Andrew Wyrobek Lawrence Berkeley National Laboratory Abstract The objectives of this research are to characterize the early and persistent low-dose and adaptive response (AR) damage surveillance networks in mammary glands of radiation sensitive and resistant strains of mice to identify the molecular signatures/mechanisms associated with nonlinear modifications of risk for mammary gland cancer. Our approach uses low-dose exposure regimens that have been reported to induce mammary gland cancer in sensitive strains to determine whether low-dose induced pathways are differentially expressed in epithelial or stromal cells and to determine

31

Unraveling the microenvironmental influences on the normal mammary gland and induction and progression of breast cancer  

SciTech Connect

The normal mammary gland and invasive breast cancer are both complex 'organs' composed of multiple cell types as well as extracellular matrix (ECM) in three-dimensional (3D) space. Conventionally, both normal and malignant breast cells are studied in vitro as two-dimensional (2D) monolayers of epithelial cells, which results in the loss of structure and tissue function. Many laboratories are now investigating regulation of signaling function in normal mammary gland using 3D cultures. However, it is important also to assay malignant breast cells ex vivo in a physiologically relevant environment to more closely mimic tumor architecture, signal transduction regulation and tumor behavior in vivo. Here we present the potential of these 3D models for drug testing, target validation and guidance of patient selection for clinical trials. We argue also that in order to get full insight into the biology of the normal and malignant breast, and to create in vivo-like models for therapeutic approaches in humans, we need to continue to create more complex heterotypic models to approach the full context the cells encounter in the human body.

Weigelt, Britta; Bissell, Mina J.

2008-06-26T23:59:59.000Z

32

Oncogene-Mediated Human Lung Epithelial Cell Transformation Produces Adenocarcinoma Phenotypes In Vivo  

Science Journals Connector (OSTI)

...It has been challenging to engineer lung adenocarcinoma models...challenges facing the field is to engineer transformed lung epithelial...at 37C under a low oxygen environment (3% O2 and 5% CO2) in...It has been challenging to engineer lung adenocarcinoma models...

Ken Sasai; Taiko Sukezane; Emmy Yanagita; Harumi Nakagawa; Azusa Hotta; Tomoo Itoh; and Tsuyoshi Akagi

2011-04-01T23:59:59.000Z

33

A tool for the quantitative spatial analysis of mammary gland epithelium  

SciTech Connect

In this paper we present a method for the spatial analysis of complex cellular systems based on a multiscale study of neighborhood relationships. A function to measure those relationships, M, is introduced. The refined Relative Neighborhood Graph is then presented as a method to establish vicinity relationships within layered cellular structures, and particularized to epithelial cell nuclei in the mammary gland. Finally, the method is illustrated with two examples that show interactions within one population of epithelial cells and between two different populations.

Ortiz de Solorzano, Carlos; Fernandez-Gonzalez, Rodrigo

2004-04-09T23:59:59.000Z

34

Inhibition by Parvovirus H-1 of the Formation of Tumors in Nude Mice and Colonies in Vitro by Transformed Human Mammary Epithelial Cells  

Science Journals Connector (OSTI)

...Melero was also funded by the Departamento de Educacion del Gobierno de Navarra, Departamento de Salud del Gobierno de Navarra, Redes tematicas de investigacion cooperativa RETIC (RD06/0020/0065), European commission VII framework program (ENCITE...

Thierry Dupressoir; Jean-Marc Vanacker; Jan J. Cornelis; Nadine Duponchel; Jean Rommelaere

1989-06-15T23:59:59.000Z

35

Isolation of Two Distinct Epithelial Cell Lines from a Single Feline Mammary Carcinoma with Different Tumorigenic Potential in Nude Mice and Expressing Different Levels of Epidermal Growth Factor Receptors  

Science Journals Connector (OSTI)

...vitro to the in vivo situation. A more fundamental question is whether abnormal expres sion...Jones, and G. Migaki (eds.). Handbook Animal Models of Human Disease, Fascini...Comparative Pathology, Washington, DC: Armed Forces Institute of Pathology, 1987. 4. Stolwijk...

Jules M. H. M. Minke; Ed Schuuring; Raymond van den Berghe; John A. M. Stolwijk; Johannes Boonstra; Cees Cornelisse; John Hilkens; and Wim Misdorp

1991-08-01T23:59:59.000Z

36

Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells  

SciTech Connect

Chronic arsenic exposure remains a human health risk; however a clear mode of action to understand gene signaling-driven arsenic carcinogenesis is currently lacking. This study chronically exposed human lung epithelial BEAS-2B cells to low-dose arsenic trioxide to elucidate cancer promoting gene signaling networks associated with arsenic-transformed (B-As) cells. Following a 6 month exposure, exposed cells were assessed for enhanced cell proliferation, colony formation, invasion ability and in vivo tumor formation compared to control cell lines. Collected mRNA was subjected to whole genome expression microarray profiling followed by in silico Ingenuity Pathway Analysis (IPA) to identify lung carcinogenesis modes of action. B-As cells displayed significant increases in proliferation, colony formation and invasion ability compared to BEAS-2B cells. B-As injections into nude mice resulted in development of primary and secondary metastatic tumors. Arsenic exposure resulted in widespread up-regulation of genes associated with mitochondrial metabolism and increased reactive oxygen species protection suggesting mitochondrial dysfunction. Carcinogenic initiation via reactive oxygen species and epigenetic mechanisms was further supported by altered DNA repair, histone, and ROS-sensitive signaling. NF-?B, MAPK and NCOR1 signaling disrupted PPAR?/?-mediated lipid homeostasis. A pro-cancer gene signaling network identified increased survival, proliferation, inflammation, metabolism, anti-apoptosis and mobility signaling. IPA-ranked signaling networks identified altered p21, EF1?, Akt, MAPK, and NF-?B signaling networks promoting genetic disorder, altered cell cycle, cancer and changes in nucleic acid and energy metabolism. In conclusion, transformed B-As cells with their whole genome expression profile provide an in vitro arsenic model for future lung cancer signaling research and data for chronic arsenic exposure risk assessment. Highlights: ? Chronic As{sub 2}O{sub 3} exposure to lung epithelial cells resulted in a cancer-like phenotype. ? Mice injected with arsenic transformed (B-As) cells displayed metastatic tumors. ? Microarray profiling revealed changes in mitochondrial metabolism and ROS response. ? p21, EF1?, Akt, MAPK, PPAR? and NF-?B networks promoted pro-cancer signaling. ? B-As cells represent a lung cancer model to explore As-associated carcinogenesis.

Stueckle, Todd A., E-mail: tstueckle@hsc.wvu.edu [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States); Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Lu, Yongju, E-mail: yongju6@hotmail.com [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States); Davis, Mary E., E-mail: mdavis@wvu.edu [Department of Physiology, West Virginia University, Morgantown, WV 26506 (United States); Wang, Liying, E-mail: lmw6@cdc.gov [Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States)] [Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Jiang, Bing-Hua, E-mail: bhjiang@jefferson.edu [Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 (United States)] [Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Holaskova, Ida, E-mail: iholaskova@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Schafer, Rosana, E-mail: rschafer@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Barnett, John B., E-mail: jbarnett@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Rojanasakul, Yon, E-mail: yrojan@hsc.wvu.edu [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)

2012-06-01T23:59:59.000Z

37

Gene expression analysis of human primary prostate epithelial and fibroblast cell cultures to an acute dose of 10cGy  

NLE Websites -- All DOE Office Websites (Extended Search)

26, 2011 26, 2011 Gene expression analysis of human primary prostate epithelial and fibroblast cell cultures to an acute dose of 10cGy J. Tyson McDonald, Julia Fox, Heather Szelag, Annie Kang, Heiko Enderling, Peter Nowd, Douglas Scheinder, Giannoula Lakka Klement, Ingolf Tuerk, and Lynn Hlatky Center of Cancer Systems Biology, Steward St. Elizabeth's Medical Center, 736 Cambridge Street, Boston, Massachusetts 02135. Primary tissue represents a better model for studies than immortalized cell lines that are adapted

38

Toll like receptor-3 priming alters diesel exhaust particle-induced cytokine responses in human bronchial epithelial cells  

Science Journals Connector (OSTI)

Abstract Inflammation is considered central in the pathology of health effects from airborne particulate matter (PM). Preexisting inflammatory disorders, such as asthma, but also pulmonary infections, appear to be a risk factor of adverse health effects from PM exposure. Thus, to assess whether and how preexisting inflammation may sensitize lung cells toward additional proinflammatory effects of PM, human bronchial epithelial cells (BEAS-2B) were primed with the highly proinflammatory Toll-like receptor 3 (TLR3) ligand, Poly I:C, prior to exposure with diesel exhaust particles (DEP). DEP-exposure alone induced increased gene-expression of interleukin-6 (IL-6) and CXCL8 (IL-8) but did not affect expression of CCL5 (RANTES), while TLR3-priming alone induced expression of IL-6, CXCL8 and CCL5. DEP-exposure exacerbated IL-6 and CXCL8 responses in TLR3-primed cells, while TLR3-induced CCL5 was suppressed by DEP. TLR3-priming and DEP-exposure resulted in possible additive effects on p38 phosphorylation and I?B-degradation, while DEP rather suppressed ERK and JNK-activation. However, TLR3-priming elicited a considerable increase in p65-phosphorylation at serine 536 which is known to enhance the transcriptional activity of NF-?B. DEP-exposure was unable to induce p65-phosphorylation. Thus TLR3-priming may affect susceptibility toward DEP by activating both shared and complementing pathways required for optimal expression of proinflammatory genes such as IL-6 and CXCL8. The study underscores that primed sick cells may be more susceptible toward effects of particle-exposure and respond both stronger and differently compared to unprimed healthy cells.

Nicolai S. Bach; Marit Lg; Johan vrevik

2014-01-01T23:59:59.000Z

39

Genetic susceptibility to low-dose ionizing radiation in the mouse mammary  

NLE Websites -- All DOE Office Websites (Extended Search)

Genetic susceptibility to low-dose ionizing radiation in the mouse mammary Genetic susceptibility to low-dose ionizing radiation in the mouse mammary gland as a means of understanding human risk for breast cancer Antoine M. Snijders Lawrence Berkeley National Laboratory Abstract Goal: Our goal is to develop an in vivo mechanistic model of genetic variation in the low-dose damage responses of mammary glands using inbred mice known to vary in their sensitivity to low-dose induced mammary gland cancer, and to develop molecular predictors for susceptibility or resistance to low-dose induced breast cancer. Background and Significance: It is increasingly believed that individuals differ in their genetic susceptibilities to environmental insults for diseases such as cancer. This concern is especially important for the large numbers of individuals receiving low-dose exposures in the nuclear energy

40

Abstract 3464: Epigenetic mechanism is involved in depleted uranium-induced transformation in human lung epithelial cells  

Science Journals Connector (OSTI)

...Epigenetic mechanism is involved in depleted uranium-induced transformation in human...Southern Maine, Portland, ME. Depleted uranium (DU) is commonly used in military...research information on the potential health hazards of DU exposure. In our...

Hong Xie; Carolyne LaCerte; and John P. Wise

2010-04-15T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Abstract A20: Deacetylation of histone H3 at lysine 9 with ethanol in human colonic epithelial cells  

Science Journals Connector (OSTI)

...Modulation of PPARalpha and PPARbeta by ethanol in human breast cancer cell lines Nagaraj...14-18, 2007; Los Angeles, CA 3464 Ethanol consumption is associated with an increased...mechanisms involved are still unclear. Ethanol modulates isoforms of the peroxisome proliferator-activated...

Hyeran Jang; Mary Moyer; Sang-Woon Choi

2008-11-01T23:59:59.000Z

42

Factors Influencing Expression of Mammary Ductal Dysplasia in Cell Dissociation-derived Murine Mammary Outgrowths  

Science Journals Connector (OSTI)

...Michigan 48201 [S. P. E. ,and Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830 [R. L U.J ABSTRACT The expression...lesions of the mammary ducts (9, 10). Several workers have reported the detection of mammary ductal...

Stephen P. Ethier and Robert L. Ullrich

1984-10-01T23:59:59.000Z

43

E-Print Network 3.0 - advanced ovarian epithelial Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

as an animal model of human epithelial ovarian cancer (15, 26). ... Source: Mayo, Kelly E. - Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern...

44

E-Print Network 3.0 - advanced epithelial ovarian Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

as an animal model of human epithelial ovarian cancer (15, 26). ... Source: Mayo, Kelly E. - Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern...

45

Neutron-induced Mammary Neoplasms in the Rat  

Science Journals Connector (OSTI)

...Research, Inc. May 1972 research-article Neutron-induced Mammary Neoplasms in the Rat...Medicine, Memphis, Tennessee 38103 Fission neutrons are effective in producing mammary neoplasms...does not hold after exposure to fission neutrons, at least from 10 to 250 rads, in single...

Howard H. Vogel, Jr. and Robert Zaldvar

1972-05-01T23:59:59.000Z

46

Neutron-induced Mammary Neoplasms in the Rat  

Science Journals Connector (OSTI)

...Fission neutrons were appropriately...y-rays or thermal neutrons (12). The neutron fission spectrum (mean energy, about 1...changing the neutron energy from the fission spectrum to 540 keV...the types of induced mammary neoplasms...

Howard H. Vogel, Jr. and Robert Zaldvar

1972-05-01T23:59:59.000Z

47

Regulation of epithelial-mesenchymal transition and DNA damage responses by singleminded-2s  

E-Print Network (OSTI)

repressor Singleminded-2, is lost or repressed in approximately 70% of human breast tumors and has a profound influence on normal mammary development. In order to gain a better understanding of the mechanisms by which SIM2s restricts malignant transformation...

Laffin, Brian Edward

2009-05-15T23:59:59.000Z

48

Effects of Dietary Energy Restriction on Gene Regulation in Mammary Epithelial Cells  

Science Journals Connector (OSTI)

...pink, light blue, and dark blue) is directly related...carcinomas at the 10 false discovery rate was P 0.037...genes influencing the energy metabolism in MGEC and...MG-20 DER, 20 dietary energy-restricted MGECs; MG-40 DER, 40 dietary energy-restricted MGECs...

Zongjian Zhu; Weiqin Jiang; John N. McGinley; Jennifer M. Price; Bifeng Gao; and Henry J. Thompson

2007-12-15T23:59:59.000Z

49

Effects of Dietary Energy Restriction on Gene Regulation in Mammary Epithelial Cells  

Science Journals Connector (OSTI)

...compounds, including energy, saturated fat...We measured diet quality with the HEI-2005...with better dietary quality were more physically...reported lower daily energy intake and weekly...components (40), is energy adjusted, facilitates...better versus poor quality diets, and can be...

Zongjian Zhu; Weiqin Jiang; John N. McGinley; Jennifer M. Price; Bifeng Gao; and Henry J. Thompson

2007-12-15T23:59:59.000Z

50

Effects of Dietary Energy Restriction on Gene Regulation in Mammary Epithelial Cells  

Science Journals Connector (OSTI)

...Prevention Effects of Dietary Energy Restriction on Gene Regulation...determine whether dietary energy restriction (DER) affects...breast cancer research. New York: Kluwer Academic/Plenum...HJ. Effects of dietary energy repletion and IGF-1 infusion...

Zongjian Zhu; Weiqin Jiang; John N. McGinley; Jennifer M. Price; Bifeng Gao; and Henry J. Thompson

2007-12-15T23:59:59.000Z

51

Phenotypic Characteristics of Cell Lines Derived from Disseminated Cancer Cells in Bone Marrow of Patients with Solid Epithelial Tumors: Establishment of Working Models for Human Micrometastases  

Science Journals Connector (OSTI)

...serum deprivation. Exp. Cell Res., 224: 208-213, 1996. 59 Van der Velde-Zimmermann D., Verdaasdonk M. A., Rademakers L. H., De Weger R. A., Van den Tweel J. G., Jogling P. Fibronectin distribution in human bone marrow stroma: matrix...

Elmar Putz; Klaus Witter; Sonja Offner; Peter Stosiek; Alfred Zippelius; Judith Johnson; Robert Zahn; Gert Riethmller; Klaus Pantel

1999-01-01T23:59:59.000Z

52

Abstract #2266: Cables 1 knockdown in immortalized human ovarian surface epithelial cells results in their uptake of more malignant like characteristics  

Science Journals Connector (OSTI)

...2009; Denver, CO Abstract #2266: Cables 1 knockdown in immortalized human ovarian...Meeting-- Apr 18-22, 2009; Denver, CO Cables 1 is best known as a cyclin-dependent...Previously we reported that loss of Cables 1 expression was observed with high frequency...

Hideo Sakamoto; Anne Friel; Lawrence Zukerberg; Ronny Drapkin; Bo Rueda

2009-05-01T23:59:59.000Z

53

Identification of the Apoptosis Activation Cascade Induced in Mammary Carcinomas by Energy Restriction  

Science Journals Connector (OSTI)

...Induced in Mammary Carcinomas by Energy Restriction Henry J. Thompson...University, Fort Collins, Colorado Energy restriction (ER) inhibits...17: 3237-3245, 1998. 33 Green D. R. Apoptotic pathways...induced in mammary carcinomas by energy restriction. | Energy restriction...

Henry J. Thompson; Zongjian Zhu; and Weiqin Jiang

2004-02-15T23:59:59.000Z

54

Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function  

SciTech Connect

Epithelial cells, once dissociated and placed in two-dimensional (2D) cultures, rapidly lose tissue-specific functions. We showed previously that in addition to prolactin, signaling by laminin-111 was necessary to restore functional differentiation of mammary epithelia. Here, we elucidate two additional aspects of laminin-111 action. We show that in 2D cultures, the prolactin receptor is basolaterally localized and physically segregated from its apically placed ligand. Detachment of the cells exposes the receptor to ligation by prolactin leading to signal transducers and activators of transcription protein 5 (STAT5) activation, but only transiently and not sufficiently for induction of milk protein expression. We show that laminin-111 reorganizes mammary cells into polarized acini, allowing both the exposure of the prolactin receptor and sustained activation of STAT5. The use of constitutively active STAT5 constructs showed that the latter is necessary and sufficient for chromatin reorganization and {beta}-casein transcription. These results underscore the crucial role of continuous laminin signaling and polarized tissue architecture in maintenance of transcription factor activation, chromatin organization, and tissue-specific gene expression.

Xu, Ren; Nelson, Celeste M.; Muschler, John L.; Veiseh, Mandana; Vonderhaar, Barbara K.; Bissell, Mina J.

2009-06-03T23:59:59.000Z

55

Regression of Human Metastatic Mammary Cancer Induced by 3-Methylcholanthrene  

Science Journals Connector (OSTI)

...Israel and Egypt! We do have the usual health hazard warnings, ofcourse. Fig. 8 is...paraphrased, says, oeWarning. The Health Officer Has Determined That Wading is Dangerous To Your Health. Epidemiology of Survival What happens...

Charles Huggins and Jack D. McCarthy

1957-11-01T23:59:59.000Z

56

Regression of Human Metastatic Mammary Cancer Induced by 3-Methylcholanthrene  

Science Journals Connector (OSTI)

...question of the relative health risk of LN-SLT products...products to be far less dangerous than conventional cigarettes...government officials or public health experts to characterize...products as comparably dangerous with cigarette smoking...in tobacco-related health risks in an exciting...

Charles Huggins and Jack D. McCarthy

1957-11-01T23:59:59.000Z

57

Spontaneous Metastasis from Primary C3H Mouse Mammary Tumors  

Science Journals Connector (OSTI)

...2 sublines of the C3H strain, the exogenous (milk transmit ted) mouse mammary tumor virus-infectedC3H/He and the aforemen...140-147, 1983. 20. Cam, Y., Caulet, T., Bellon, G., Poulin, G., Legros, M., and Pytlinska, M. Immunohistochemical...

Jan Vaage and James P. Harlos

1987-01-15T23:59:59.000Z

58

Cytochemical Studies on the Mouse Mammary Tumor Virus  

Science Journals Connector (OSTI)

...Elaboration in C3H Mouse Mammary Car cinoma as Observed by...and Bernhard, W. Water Soluble Embedding Media...Hydroxypropyl Methacrylate, a New Water-miscible Embedding Medium...Bernhard, W. The Use of Water-soluble Glycol Methacrylate...Smith FIG. 5. Low-power micrograph showing the...

Gilbert H. Smith

1967-11-01T23:59:59.000Z

59

Original article Sensitization of the bovine mammary gland to  

E-Print Network (OSTI)

(ReceivedI October I )96; accepted 4 February 1997) Summary ― The effect of repeated infusions intramammary infusions of E cnli endotoxin (33 pg) 24 h apart in the same mammary quarter. Along with the second infusion, the cows received one dose of endotoxin in the contralateral quarter. Milk was collected

Boyer, Edmond

60

Estrogen-related Receptor ? and Estrogen-related Receptor ? Associate with Unfavorable and Favorable Biomarkers, Respectively, in Human Breast Cancer  

Science Journals Connector (OSTI)

...Fishers exact, P 0.006; Kruskal-Wallis ANOVA, P 0.021). ERRa levels...normal mammary epithelial cells (Kruskal-Wallis ANOVA, P 0.001). ERR overexpression...were tested by the nonparametric Kruskal-Wallis ANOVA (Figs. 1 2 3) . Associations...

Eric A. Ariazi; Gary M. Clark; Janet E. Mertz

2002-11-15T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Regulation of Mammary Tumor Virus Production by Prolactin in BALB/cfC3H Mouse Normal Mammary Epithelial Cells in Vitro  

Science Journals Connector (OSTI)

...prolactin and growth hormone were added to insulin- and hydmocorti sone-containing media, the stimulatory effect did not ex ceed that seen in cultures treated with prolactin, insulin, and hydrocortisone (data not shown). Among the growth hormones tested...

Jason Yang; J. Enami; S. Nandi

1977-10-01T23:59:59.000Z

62

E-Print Network 3.0 - alveolar epithelial gp60 Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

of the underlying mammary mesenchyme by the presumptive mammary epithelium to establish a bulb of ... Source: Scott, Matthew - Departments of Developmental Biology, Genetics, &...

63

Effect of Intravenous Amino Acid Infusion on Leucine Oxidation Across the Mammary Gland  

E-Print Network (OSTI)

Effect of Intravenous Amino Acid Infusion on Leucine Oxidation Across the Mammary Gland) and the AA infusion periods. Although blood flow to the mammary gland and the arterial concen- tration of most AA other than leucine were increased by the AA infusion, milk and protein yields did not change

Bequette, Brian J.

64

Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations that leads to stable epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial Cells  

E-Print Network (OSTI)

SL-1, and the cell line p2C, which was established in theshown. A fourth cell line, p2C, which was derived from SCp2Tet and SCp2 (not shown) and p2C cells maintained either in

Lochter, A.

2011-01-01T23:59:59.000Z

65

Investigation of non-targeted effects of low dose ionizing radiation on the mammary gland  

NLE Websites -- All DOE Office Websites (Extended Search)

non-targeted effects of low dose ionizing radiation on the mammary gland non-targeted effects of low dose ionizing radiation on the mammary gland utilizing three-dimensional culture models of mammary cells derived from mouse strains that differ in susceptibility to tumorigenesis Joni D. Mott, Antoine M. Snijders, Alvin Lo, Dinah Levy-Groesser, Bahram Parvin, Andrew J. Wyrobek, Jian-Hua Mao, and Mina J. Bissell Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley CA 94720 Goal: Within the Lawrence Berkeley National Laboratory's SFA, Project 2, our studies focus on utilizing three dimensional (3D) cell culture models as surrogates for in vivo studies to determine how low doses of ionizing radiation influence mammary gland tissue architecture and how this may relate both to tumor progression and/or adaptive response.

66

Effects of Physical Activity and Restricted Energy Intake on Chemically Induced Mammary Carcinogenesis  

Science Journals Connector (OSTI)

...Effects of Physical Activity and Restricted Energy Intake on Chemically Induced Mammary Carcinogenesis...little attention has been given to whether energy balance directed interventions designed to regulate body weight by increasing energy expenditure versus reducing energy intake...

Weiqin Jiang; Zongjian Zhu; Henry J. Thompson

2009-04-01T23:59:59.000Z

67

Epithelial-derived TGF-2 modulates basal and wound-healing subepithelial matrix homeostasis  

E-Print Network (OSTI)

conditions. We utilized an in vitro model of the epithelial-mesenchymal trophic unit in the human airways increases two- to threefold following scrape injury in a dose-depen- dent fashion and significantly enhances to epithe- lial injury. In the absence of the epithelium, exogenous active TGF- 2 (0­400 pg/ml) produces

George, Steven C.

68

A Novel Human Cytomegalovirus Glycoprotein, gpUS9, Which Promotes Cell-to-Cell Spread in Polarized Epithelial Cells, Colocalizes with the Cytoskeletal Proteins E-Cadherin and F-Actin  

Science Journals Connector (OSTI)

...solubility. Immunofluorescence laser scanning confocal microscopy...of human fibroblasts (HF) in culture (reviewed...ARPE-19) cells by fusion of the virion envelope...Immunofluorescence laser scanning confocal microscopy...cultures of nonpolarized HF (, , ). Since a substantial...

Ekaterina Maidji; Sharof Tugizov; Gerardo Abenes; Thomas Jones; Lenore Pereira

1998-07-01T23:59:59.000Z

69

Annexin A9 (ANXA9) biomarker and therapeutic target in epithelial cancer  

DOE Patents (OSTI)

Amplification of the ANXA9 gene in human chromosomal region 1q21 in epithelial cancers indicates a likelihood of both in vivo drug resistance and metastasis, and serves as a biomarker indicating these aspects of the disease. ANXA9 can also serve as a therapeutic target. Interfering RNAs (iRNAs) (such as siRNA and miRNA) and shRNA adapted to inhibit ANXA9 expression, when formulated in a therapeutic composition, and delivered to cells of the tumor, function to treat the epithelial cancer.

Hu, Zhi (El Cerrito, CA); Kuo, Wen-Lin (San Ramon, CA); Neve, Richard M. (San Mateo, CA); Gray, Joe W. (San Francisco, CA)

2012-06-12T23:59:59.000Z

70

Effect of Dietary Palm Oils on Mammary Carcinogenesis in Female Rats Induced by 7,12-Dimethylbenz(a)anthracene  

Science Journals Connector (OSTI)

...Sciences Effect of Dietary Palm Oils on Mammary Carcinogenesis in...research grant from the Palm Oil Research Institute of Malaysia...from 200 to 230 Cat 2 C/min. Peak areas were quantified by an electronic...both contain 1447 DIETARY PALM OIL AND MAMMARY CANCER Table 1 Composition...

K. Sundram; H. T. Khor; Augustune S. H. Ong; and R. Pathmanathan

1989-03-15T23:59:59.000Z

71

Tissue architecture: the ultimate regulator of breast epithelial function  

SciTech Connect

A problem in developmental biology that continues to take center stage is how higher organisms generate diverse tissues and organs given the same cellular genotype. In cell and tumor biology, the key question is not the production of form, but its preservation: how do tissues and organs maintain homeostasis, and how do cells within tissues lose or overcome these controls in cancer? Undoubtedly, mechanisms that maintain tissue specificity should share features with those employed to drive formation of the tissues. However, they are unlikely to be identical. At a simplistic level, developmental pathways may be thought of as a series of extremely rapid short-term events. Each new step depends on what came before, and the outcome is the organism itself at birth. All organs, with a few notable exceptions, such as the mammary gland and the brain, 'arrive' together and are complete when the organism is born. In mice and humans, these events occur in a mere 21 days and 9 months respectively. The stability of the differentiated state and the homeostasis of the organism, on the other hand, will last 40-110 times longer. How does the organism achieve this feat? How are tissues maintained? These questions also relate fundamentally to how tissues become malignant and, although not discussed here, to aging. While there is much literature on differentiation - loosely defined as the gain of a single or a series of functions - we know much less about the forces and the pathways that maintain organ morphology and function as a unit. This may be partly because it is difficult to study a tissue as a unit in vivo and there are few techniques that allow maintenance of organs in vitro long enough and in such a way as to make cell and molecular biology experiments possible. Techniques for culturing cells in three-dimensional gels (3D) as a surrogate for tissues, however, have been steadily improving and the method is now used by several laboratories. In this commentary we discuss the following: first, how our laboratory came to develop a model of the mammary gland acinus; second, what this model has told us about mechanisms that govern tissue specificity and malignancy; and third, possible directions for future studies. We summarize the evidence for the central role of ECM signaling in the maintenance of mammary function in culture and (more briefly) its role in tumorigenesis. This is followed by a discussion of the role that tissue architecture and tissue polarity (as opposed to cell polarity) may play in these processes. In an elegantly written and reasoned essay, Kirschner et al. coined the new science of developmental biology 'molecular vitalism'. They framed new concepts for self-organization as well as schemes for information flow in biological organization. Rao et al. reviewed and elaborated on differential-equation-based models of biochemical reaction networks and intracellular noise, with emphasis on bacteria and phage. Similarly, Hartwell et al. discussed the synergy between experiment and theory in elucidating 'modules' - collections of interacting molecules - and in unraveling how these modules collaborate to perform cellular functions such as signal transduction. We believe that many of these ideas will also be applicable to the maintenance of tissue specificity. As much as we agree with Kirschner et al. regarding the limitations of the machine analogy to biological systems, we conclude with thoughts on how we may proceed to model the complex tissue networks that govern breast tissue architecture. We suggest that our understanding of the structure and function of breast tissue would benefit from examining recent techniques for modeling large complex networks such as the World Wide Web and the Internet backbone among others.

Bissell, Mina J; Rizki, Aylin; Mian, Saira

2003-10-20T23:59:59.000Z

72

Regulation of Mammary cell Differentiation and Metabolism by Singleminded-2s  

E-Print Network (OSTI)

mammary gland has also been shown to enhance metastasis, and the gene expression signature of the involuting gland has been associated with poor prognoses in breast cancer diagnosis (Marti et al., 1999; McDaniel et al., 2006; Schedin et al., 2007; Stein... profile similar to the involuting mammary gland (Clarkson and Watson, 2003; Clarkson et al., 2004; Come et al., 2004; Henson and Tarone, 1994; Jager et al., 1997; Lefebvre et al., 1992; Lyons et al., 2009; McDaniel et al., 2006; O'Brien and Schedin...

Scribner, Kelly C

2013-05-21T23:59:59.000Z

73

Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53-Null Mammary Carcinomas  

Science Journals Connector (OSTI)

...Radiation Acts via the Microenvironment to Promote Aggressive Trp53-Null Mammary...changes from radiation contribute strongly to carcinogenic potential. Densely ionizing...radiation chimera in which mice were exposed to densely ionizing 350 MeV/amu Si-particles...

Irineu Illa-Bochaca; Haoxu Ouyang; Jonathan Tang; Christopher Sebastiano; Jian-Hua Mao; Sylvain V. Costes; Sandra Demaria; Mary Helen Barcellos-Hoff

2014-12-01T23:59:59.000Z

74

Further Investigations on Induction of Mammary Cancer in Mice by Isografts of Hypophyseal Tissue  

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...in dependently to select the positive reactors "name ly: (a) The conversion of the...644586452472328Exp.QROUPVWX strates the reliability of the selection method employed. Mammary...described above are unsuitable for a complete analysis, since this investigation was primarily...

L. M. Boot; O. Mhlbock; G. Rpcke; and W. van Ebbenhorst Tengbergen

1962-07-01T23:59:59.000Z

75

Angiogenic Capacity of Preneoplastic Lesions of the Murine Mammary Gland as a Marker of Neoplastic Transformation  

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...many tissues studied. This process resulted in destruction of the...the important stages in this process remain undefined (16). In...currently thought to be a multistage process, in which the HAN nepre sents...of Mouse Mammary Tumor Strain MTG-B. Proc. Soc. Exptl. Biol...

Michael A. Gimbrone, Jr. and Pietro M. Gullino

1976-07-01T23:59:59.000Z

76

Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated  

E-Print Network (OSTI)

secretion of milk­lipid droplets Sherry L. Ogg*, Anne K. Weldon*, Lorraine Dobbie , Andrew J. H. Smith expressed in the lactating mammary gland and is secreted into milk in association with lipid droplets expression of Btn1a1 was either disrupted or eliminated, respectively. The regulated secretion of milk­lipid

Mather, Ian

77

Assessment of Radiogenic Cancer Initiation Frequency per Clonogenic Rat Mammary Cell in Vivo  

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...X-rays from a General Electric Maxitron 300 with 3 mm Al...first and subsequent mammary car cinomas are not independent...D0 = 127 cGy low linear energy transfer irradiation and...differences in latencies of car cinomas from grafted cells...

Kelly H. Clifton; Martin A. Tanner; and Michael N. Gould

1986-05-01T23:59:59.000Z

78

Treatment of an Iatrogenic Left Internal Mammary Artery to Pulmonary Artery Fistula with a Bovine Pericardium Covered Stent  

SciTech Connect

We report a case with an acquired fistula between the left internal mammary artery and the pulmonary artery following coronary bypass surgery treated with a bovine pericardium covered stent. We also reviewed similar cases reported previously.

Heper, Gulumser [SSK Ihtisas Hospital, Department of Cardiology (Turkey)], E-mail: heperg@hotmail.com; Barcin, Cem; Iyisoy, Atila; Tore, Hasan F. [Gulhane Military Medical Academy, Department of Cardiology (Turkey)

2006-10-15T23:59:59.000Z

79

Detection of Ductal Dysplasia in Mammary Outgrowths Derived from Carcinogen-treated Virgin Female BALB/c Mice  

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...National Laboratory [R. L. U.], Oak Ridge, Tennessee 37830 ABSTRACT These...mammary cells. In addition, several workers have reported that expression of...studied by Medina (17). These workers have performed serial transplan tation...

Stephen P. Ethier and Robert L. Ullrich

1982-05-01T23:59:59.000Z

80

Depleted uranium - induced malignant transformation in human lung epithelial cells.  

Science Journals Connector (OSTI)

...transmission of genetic damage by depleted uranium and tungsten alloy Alexandra Miller...The radioactive heavy metal, depleted uranium (DU), an alpha-particle emitter...fragments will affect the long-term health of offspring conceived by these...

Aldona A. Karaczyn; Hong Xie; and John P. Wise

2006-04-15T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Depleted uranium - induced malignant transformation in human lung epithelial cells.  

Science Journals Connector (OSTI)

...Association for Cancer Research 15 April...Proc Amer Assoc Cancer Res, Volume 47, 2006 Depleted uranium - induced malignant...Proc Amer Assoc Cancer Res, Volume 47, 2006] 5215 Depleted uranium (DU) has been...

Aldona A. Karaczyn; Hong Xie; and John P. Wise

2006-04-15T23:59:59.000Z

82

Depleted uranium - induced malignant transformation in human lung epithelial cells.  

Science Journals Connector (OSTI)

...Washington, DC Abstract 3590: Depleted uranium-induced leukemia: Epigenetic...with leukemia development. Depleted uranium is used in military missions...Karvelisse Miller, Max Costa. Depleted uranium-induced leukemia: Epigenetic...

Aldona A. Karaczyn; Hong Xie; and John P. Wise

2006-04-15T23:59:59.000Z

83

Mechanical compression attenuates normal human bronchial epithelial wound healing  

E-Print Network (OSTI)

Open Access Research Mechanical compression attenuatesto the application of mechanical compression in the presenceResults: We found that mechanical compression and scrape

Arold, Stephen P.; Malavia, Nikita; George, Steven C.

2009-01-01T23:59:59.000Z

84

MicroRNA expression in canine mammary cancer  

E-Print Network (OSTI)

to act as both tumor suppressors and oncogenes in several different cancers, expression patterns of ten miRNAs (miR-15a, miR-16, miR-17-5p, miR-21, miR-29b, miR-125b, miR-145, miR-155, miR-181b, let-7f) known to be associated with human breast cancer were...

Boggs, Rene' Michelle

2008-10-10T23:59:59.000Z

85

Effect of Preirradiation of the Tumor Bed on the Relative Vascular Space of Mouse Gastric Adenocarcinoma 328 and Mammary Adenocarcinoma CA755  

Science Journals Connector (OSTI)

...viable portions of tumors of the MTG-B strain show an accelerating...not reflect the fundamental processes occurring in those areas of...Growth and Cell Loss in the MTG-B Mouse Mammary Carcinoma...of Mouse Mammary Tumor Strain MTG-B. Proc. Soc. Exptl. Biol...

Randy Jirtle and Kelly H. Clifton

1973-04-01T23:59:59.000Z

86

E-Print Network 3.0 - alveolar epithelial type Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

cells. Alveolar epithelial cells adherence to type I collagen was decreased... M CaCl2. Cell cultures Isolation and primary culture of alveolar epithelial cells Alveolar...

87

E-Print Network 3.0 - anogenital epithelial cells Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

185-194 Plasticity of epithelial cell shape in response... expresses enhanced green fluorescent protein (eGFP) specifically in the ectodermal epithelial cells... to analyze the...

88

Morphologically Normal-Appearing Mammary Epithelial Cells Obtained from High-Risk Women Exhibit Methylation Silencing of INK4a/ARF  

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...CA58207 (T.D. Tlsty). The costs of publication of this article...Review Board at Duke University Medical Center, in accordance with...were used under reduced lighting and stored in a desiccator...initial RPFNA at Duke University Medical Center from March 2003 to August...

Gregory R. Bean; Andrew D. Bryson; Patrick G. Pilie; Vanessa Goldenberg; Joseph C. Baker, Jr.; Catherine Ibarra; Danielle M.U. Brander; Carolyn Paisie; Natalie R. Case; Mona Gauthier; Paul A. Reynolds; Eric Dietze; Julie Ostrander; Victoria Scott; Lee G. Wilke; Lisa Yee; Bruce F. Kimler; Carol J. Fabian; Carola M. Zalles; Gloria Broadwater; Thea D. Tlsty; and Victoria L. Seewaldt

2007-11-15T23:59:59.000Z

89

Comparative promoter activities of three endogenous copies of mouse mammary tumor virus  

E-Print Network (OSTI)

to 12 CC ~ o c 0 tu x MMTV M13 pLC1 ?(, a~ CAT pBR322 0/ I SV40 Figure 5. Diagram of pLC1. The plasmid pLC1 (Toohey et al. , 1986) contains an Intact LTR obtained from the C3H provirus as a Pst I restriction fragment. The plasmid also...COMPARATIVE PROMOTER ACTIVITIES OF THREE ENDOGENOUS COPIES OF MOUSE MAMMARY TUMOR VIRUS A Thesis by LAURA REID VILANDER Submitted to the Graduate College of Texas A&M University in partial fulfilment of the requirements for the degree...

Vilander, Laura Reid

1987-01-01T23:59:59.000Z

90

Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging  

SciTech Connect

The extracellular matrix (ECM), once thought to solely provide physical support to a tissue, is a key component of a cell's microenvironment responsible for directing cell fate and maintaining tissue specificity. It stands to reason, then, that changes in the ECM itself or in how signals from the ECM are presented to or interpreted by cells can disrupt tissue organization; the latter is a necessary step for malignant progression. In this review, we elaborate on this concept using the mammary gland as an example. We describe how the ECM directs mammary gland formation and function, and discuss how a cell's inability to interpret these signals - whether as a result of genetic insults or physicochemical alterations in the ECM - disorganizes the gland and promotes malignancy. By restoring context and forcing cells to properly interpret these native signals, aberrant behavior can be quelled and organization re-established. Traditional imaging approaches have been a key complement to the standard biochemical, molecular, and cell biology approaches used in these studies. Utilizing imaging modalities with enhanced spatial resolution in live tissues may uncover additional means by which the ECM regulates tissue structure, on different length scales, through its pericellular organization (short-scale) and by biasing morphogenic and morphostatic gradients (long-scale).

Ghajar, Cyrus M; Bissell, Mina J

2008-10-23T23:59:59.000Z

91

Mammary Tumorigenesis in 7,12-Dimethybenzanthracene-treated C57BL DBA/2f F1 Mice  

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...analysis of M-406 mammary adenocarcinoma in F1 and F2 generations of a cross between resistant...characterize the tumor behavior in both F1 reciprocal hybrids [(CBi CBi-) and...M-406 grew exponentially in 45/48 F1 mice. Non statistical differences were...

Daniel Medina; Janet S. Butel; Susan H. Socher; Frances L. Miller

1980-02-01T23:59:59.000Z

92

Effect of Energy Restriction on Cell Cycle Machinery in 1-Methyl-1-Nitrosourea-induced Mammary Carcinomas in Rats  

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...relationship to the effects of energy restriction on mammary...Thompson H. J. Mechanisms of energy restriction: effects of...McGraw-Hill Publishing Co. New York 1990. 19 Zhu Z., Jiang...Thompson H. J. Effect of energy restriction on the expression...

Weiqin Jiang; Zongjian Zhu; and Henry J. Thompson

2003-03-15T23:59:59.000Z

93

Densely Ionizing Radiation Acts via the Microenvironment to Promote Aggressive Trp53-Null Mammary Carcinomas  

Science Journals Connector (OSTI)

...ionizing radiation. The unique pattern of energy deposition incurred by particle traversal...epithelial cells were positive for K18 (green).Nuclei were counterstained with DAPI...positive either for K18 or K14 (n = 20, green; D), K14+18 type with K14 and K18...

Irineu Illa-Bochaca; Haoxu Ouyang; Jonathan Tang; Christopher Sebastiano; Jian-Hua Mao; Sylvain V. Costes; Sandra Demaria; and Mary Helen Barcellos-Hoff

2014-12-01T23:59:59.000Z

94

Ultrasound Increases Nanoparticle Delivery by Reducing Intratumoral Pressure and Increasing Transport in Epithelial and EpithelialMesenchymal Transition Tumors  

Science Journals Connector (OSTI)

...Chemical Biology Ultrasound Increases Nanoparticle Delivery by Reducing Intratumoral Pressure...clinic can be used to enhance in vivo nanoparticle delivery to epithelial and EMT tumors...analysis of vascular permeability and nanoparticle accumulation in tumors. Acquisition...

Katherine D. Watson; Chun-Yen Lai; Shengping Qin; Dustin E. Kruse; Yueh-Chen Lin; Jai Woong Seo; Robert D. Cardiff; Lisa M. Mahakian; Julie Beegle; Elizabeth S. Ingham; Fitz-Roy Curry; Rolf K. Reed; Katherine W. Ferrara

2012-03-15T23:59:59.000Z

95

In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer  

Science Journals Connector (OSTI)

Diethylstilbestrol (DES) and bisphenol-A (BPA) are estrogen-like endocrine-disrupting chemicals that ... in adult women. Similarly, fetal exposure to BPA induces neoplastic changes in mammary tissue of ... of tum...

Leo F. Doherty; Jason G. Bromer; Yuping Zhou; Tamir S. Aldad

2010-06-01T23:59:59.000Z

96

Probiotics promote endocytic allergen degradation in gut epithelial cells  

SciTech Connect

Highlights: Black-Right-Pointing-Pointer Knockdown of A20 compromised the epithelial barrier function. Black-Right-Pointing-Pointer The fusion of endosome/lysosome was disturbed in the A20-deficient HT-29 cells. Black-Right-Pointing-Pointer Antigens transported across A20-deficient HT-29 monolayers conserved antigenicity. Black-Right-Pointing-Pointer Probiotic proteins increased the expression of A20 in HT-29 cells. -- Abstract: Background and aims: Epithelial barrier dysfunction plays a critical role in the pathogenesis of allergic diseases; the mechanism is to be further understood. The ubiquitin E3 ligase A20 (A20) plays a role in the endocytic protein degradation in the cells. This study aims to elucidate the role of A20 in the maintenance of gut epithelial barrier function. Methods: Gut epithelial cell line, HT-29 cell, was cultured into monolayers to evaluate the barrier function in transwells. RNA interference was employed to knock down the A20 gene in HT-29 cells to test the role of A20 in the maintenance of epithelial barrier function. Probiotic derived proteins were extracted from the culture supernatants using to enhance the expression of A20 in HT-29 cells. Results: The results showed that the knockdown of A20 compromised the epithelial barrier function in HT-29 monolayers, mainly increased the intracellular permeability. The fusion of endosome/lysosome was disturbed in the A20-deficient HT-29 cells. Allergens collected from the transwell basal chambers of A20-deficient HT-29 monolayers still conserved functional antigenicity. Treating with probiotic derived proteins increased the expression of A20 in HT-29 cells and promote the barrier function. Conclusion: A20 plays an important role in the maintenance of epithelial barrier function as shown by HT-29 monolayer. Probiotic derived protein increases the expression of A20 and promote the HT-29 monolayer barrier function.

Song, Chun-Hua [Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou (China)] [Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou (China); Liu, Zhi-Qiang [Department of Gastroenterology, The Second Hospital, Zhengzhou University, Zhengzhou (China) [Department of Gastroenterology, The Second Hospital, Zhengzhou University, Zhengzhou (China); Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON (Canada); Huang, Shelly [Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON (Canada)] [Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON (Canada); Zheng, Peng-Yuan, E-mail: medp7123@126.com [Department of Gastroenterology, The Second Hospital, Zhengzhou University, Zhengzhou (China)] [Department of Gastroenterology, The Second Hospital, Zhengzhou University, Zhengzhou (China); Yang, Ping-Chang, E-mail: yangp@mcmaster.ca [Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON (Canada)] [Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON (Canada)

2012-09-14T23:59:59.000Z

97

Abstract A05: The Mouse Tumor Biology (MTB) Database: An electronic tool for identifying and evaluating mouse and PDX models of human cancer  

Science Journals Connector (OSTI)

...human tumors and provides freely available web access to these data. MTB integrates data...cancer research community and has developed a web-based system to facilitate submission...MPD), the Biology of the Mammary Gland Web Site, and the NCI Mouse Repository. MTB...

Dale A. Begley; Debra M. Krupke; Steven B. Neuhauser; Joel E. Richardson; John P. Sundberg; Carol J. Bult; Janan T. Eppig

2014-11-01T23:59:59.000Z

98

Low Dose Radiation Research Program: Quantitative Analysis of Connexin  

NLE Websites -- All DOE Office Websites (Extended Search)

Quantitative Analysis of Connexin Expression in Cultured Colonies Quantitative Analysis of Connexin Expression in Cultured Colonies Authors: B. Parvin, Q. Yang, R. L. Henshall-Powell and M.H. Barcellos Hoff We are studying the effects of ionizing radiation on the signaling between human mammary epithelial cells and the extracellular microenvironment. To do so we use an assay based on the ability of the cells to organize into three-dimensional acini when embedded into an extracellular matrix. Although tumorigenic and non-tumorigenic mammary epithelial cells are nearly indistinguishable when cultured as monolayers, their biological character readily diverge when tissue-specific morphogenesis is analyzed. Non-malignant human mammary epithelial cells (HMEC) cultured within a reconstituted basement membrane organize into acinar-like structures with

99

REVIEW Open Access Epithelial to mesenchymal transition as a biomarker  

E-Print Network (OSTI)

subjected to injury may undergo similar transformations and thus provide new fibroblasts in the interstitium epithelial cells aberrantly expressing fibroblast-specific protein (FSP)1 in a model of mouse anti-tubular membrane disease [4]. This led Strutz et al. to hypothesize that some fibro- blasts might be derived from

Boyer, Edmond

100

No strings attached: new insights into epithelial morphogenesis  

Science Journals Connector (OSTI)

What regulates epithelial cell bending during early development? Lance Davidson comments on a paper from Zhirong Bao and colleagues where cell ingression in worm gastrulation is driven by dynamic cytoskeletal changes and cortical flow, challenging previous purse-string constriction models.

Lance A Davidson

2012-12-20T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Bile Salts and Nuclear Receptors in Biliary Epithelial Cell Pathophysiology  

E-Print Network (OSTI)

of Michigan. This opportunity to complete a research program allowed me to pursue my career as an associate receptors 17 3. Research program 19 3.1. VDR in biliary-type liver diseases 20 3.2. VDR in fatty liverBile Salts and Nuclear Receptors in Biliary Epithelial Cell Pathophysiology by Dr. Nicolas Chignard

Boyer, Edmond

102

Internal Mammary Lymph Node Irradiation Contributes to Heart Dose in Breast Cancer  

SciTech Connect

We assessed the impact of internal mammary chain radiotherapy (IMC RT) to the radiation dose received by the heart in terms of heart dose-volume histogram (DVH). Thirty-six consecutive breast cancer patients presenting with indications for IMC RT were enrolled in a prospective study. The IMC was treated by a standard conformal RT technique (50 Gy). For each patient, a cardiac DVH was generated by taking into account the sole contribution of IMC RT. Cardiac HDV were compared according to breast cancer laterality and the type of previous surgical procedure, simple mastectomy or breast conservative therapy (BCT). The contribution of IMC RT to the heart dose was significantly greater for patients with left-sided versus right-sided tumors (13.8% and 12.8% for left-sided tumors versus 3.9% and 4.2% for right-sided tumors in the BCT group and the mastectomy group, respectively; p < 0.0001). There was no statistically significant difference in IMC contribution depending on the initial surgical procedure. IMC RT contributes to cardiac dose for both left-sided and right-sided breast cancers, although the relative contribution is greater in patients with left-sided tumors.

Chargari, Cyrus [Department of Radiotherapy, Institut Gustave Roussy, Villejuif (France); Department of Radiotherapy and Medical Oncology, Hopital d'Instruction des Armees du Val-de-Grace, Paris (France); Castadot, Pierre [Department of Radio-Oncology, Institut Jules Bordet, Brussels (Belgium); MacDermed, Dhara [Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL (United States); Vandekerkhove, Christophe [Department of Medical Physics, Institut Jules Bordet, Brussels (Belgium); Bourgois, Nicolas; Van Houtte, Paul [Department of Radio-Oncology, Institut Jules Bordet, Brussels (Belgium); Magne, Nicolas, E-mail: nicolas.magne@igr.f [Department of Radiotherapy, Institut Gustave Roussy, Villejuif (France); Department of Radio-Oncology, Institut Jules Bordet, Brussels (Belgium)

2010-10-01T23:59:59.000Z

103

Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization  

E-Print Network (OSTI)

in the alveolar lumen with TEM are surrounded by a thin rim of plasma membrane-encased cytosol and the MFG membrane (Fig. 7a). This latter structure is acquired by the lipid droplet during the secretion process from the apical surface of the epithelium 13... for TEM analysis. Cell culture EpH4 cells 58 were maintained in DMEM (Life Technologies) media supplemented with 10% FCS (Sigma) at 37 C in a humidified atmosphere of 5% CO 2 . Milk collected from 24 h involuting mammary glands was incubated on cells...

Sargeant, Timothy J.; Lloyd-Lewis, Bethan; Resemann, Henrike K.; Ramos-Montoya, Antonio; Skepper, Jeremy; Watson, Christine J.

2014-10-05T23:59:59.000Z

104

Low Dose Radiation Research Program: Mary Helen Barcellos-Hoff - 2003  

NLE Websites -- All DOE Office Websites (Extended Search)

DOE Low Dose Radiation Program Workshop IV DOE Low Dose Radiation Program Workshop IV Abstract Title: TGF-β Protects Human Mammary Epithelial Cells from Radiation-Induced Centrosome Amplification Authors: Mary Helen Barcellos-Hoff, Bahram Parvin, Anna C. Erickson and Rishi Gupta Institutions: Department of Cell and Molecular Biology, Life Sciences Division, Ernest Orlando Lawrence, Berkeley National Laboratory, Berkeley, California In recent studies we have shown that ionizing radiation (IR), a known carcinogen of human and murine mammary gland, compromises human mammary epithelial cell (HMEC) polarity and multicellular organization in a manner characteristic of neoplastic progression through a heritable, non-mutational mechanism (1). Thus, when all cells are irradiated with a significant dose (2 Gy), the daughters of irradiated cells lose their

105

E-Print Network 3.0 - activation disrupts epithelial Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

185-194 Plasticity of epithelial cell shape in response... expresses enhanced green fluorescent protein (eGFP) specifically in the ectodermal ... Source: Bosch, Thomas C. G....

106

E-Print Network 3.0 - a549 lung epithelial Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

PROLIFERATION AND PROTEIN EXPRESSION OF LUNG CANCER CELLS Summary: (NSCLC) cell lines. Methods: The epithelial lung carcinoma (A549 ) and a bronchioalveolar (NCI-H358......

107

E-Print Network 3.0 - a549 epithelial cells Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

PROLIFERATION AND PROTEIN EXPRESSION OF LUNG CANCER CELLS Summary: (NSCLC) cell lines. Methods: The epithelial lung carcinoma (A549 ) and a bronchioalveolar (NCI-H358......

108

(CANCER RESEARCH 48, 1390-1397, March 15, 1988] Epoxide-metabolizing Enzymes in Mammary Gland and Liver from BALB/c Mice  

E-Print Network (OSTI)

(CANCER RESEARCH 48, 1390-1397, March 15, 1988] Epoxide-metabolizing Enzymes in Mammary Gland and Liver from BALB/c Mice and Effects of Inducers on Enzyme Activity1 Marilyn H. Suva, Roger N. Wixtrom.3.23) (EH) are hydrolytic enzymes which may play an important role in the activation and detoxification

Hammock, Bruce D.

109

Prenatal and prepubertal exposures to bisphenol A (BPA) induce genomic alterations in the rat mammary gland during the window of high susceptibility to carcinogenesis.  

Science Journals Connector (OSTI)

...and prepubertal exposures to bisphenol A (BPA) induce genomic alterations in the rat...2008; San Diego, CA 3155 Bisphenol A (BPA), a monomer used to manufacture polycarbonate...effect of prenatal or prepubertal exposure to BPA on the genomic signature of rat mammary...

Julia Pereira; Mario Medvedovic; Raquel Moral; Irma Russo; Coral Lamartiniere; Jose Russo

2008-05-01T23:59:59.000Z

110

Genetic Bases of Estrogen-Induced Tumorigenesis in the Rat: Mapping of Loci Controlling Susceptibility to Mammary Cancer in a Brown Norway ACI Intercross  

Science Journals Connector (OSTI)

...E2-induced pyometritis in the Brown Norway rat, to RNO5. Mamm Genome...McComb RD, Shull JD. Dietary energy restriction inhibits estrogen-induced...to mammary cancer in a Brown Norway x ACI intercross. | Exposure...strain and the unrelated Brown Norway (BN) rat strain. Whereas...

Beverly S. Schaffer; Cynthia M. Lachel; Karen L. Pennington; Clare R. Murrin; Tracy E. Strecker; Martin Tochacek; Karen A. Gould; Jane L. Meza; Rodney D. McComb; and James D. Shull

2006-08-01T23:59:59.000Z

111

Abstract 476: Mammary tumors in lipocalin-2 deficient MMTV-PyVT mice grow faster but show decreased metastasis to lung  

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...Mammary tumors in lipocalin-2 deficient MMTV-PyVT mice grow faster but show decreased metastasis to lung Heiman Chow 1 Pengcheng Fan 1 Aimin Xu 1 Wen Laun Wendy Hsiao 2 Yu Wang 1 1Department of Pharmacology and Pharmacy, The University of Hong Kong...

Heiman Chow; Pengcheng Fan; Aimin Xu; Wen Laun Wendy Hsiao; Yu Wang

2011-01-10T23:59:59.000Z

112

Effects of Hypothyroidism on the Induction and Growth of Mammary Cancer Induced by 7,12-Dimethylbenz(a)anthracene in the Rat  

Science Journals Connector (OSTI)

...finding that hypothyroidism does not enhance DMBA-induced development...observed that hypothyroidism does not enhance the induction or...mammary carcinoma in the rat and does not alter its estrogen dependence...Kintz, B. L. Computational Handbook of Statistics, Ed. 2, pp...

A. David Goodman; Susan J. Hoekstra; and Patricia S. Marsh

1980-07-01T23:59:59.000Z

113

The int-2 gene product acts as a growth factor and substitutes for basic fibroblast growth factor in promoting the differentiation of a normal mouse mammary epithelial cell line  

Science Journals Connector (OSTI)

...timepoint, one biopsy is depicted as a single pie chart at each 2-cm interval from the gastroesophageal junction (GEJ) with each pie chart showing the distribution of SCA types in each biopsy. The size of each pie chart is representational of different amounts...

T Venesio; D Taverna; NE Hynes; R Deed; D MacAllan; F Ciardiello; EM Valverius; DS Salomon; R Callahan; G Merlo

1992-01-01T23:59:59.000Z

114

Selective growth of some rodent epithelial cells in a medium containing citrulline  

Science Journals Connector (OSTI)

...TENNANT, AND A. W. HSIE Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830 Communicated by M. M. Rhoades...possessed by liver cells have enabled various workers to cultivate liver epithelial cells free of fibroblasts...

N C Sun; C R Sun; R W Tennant; A W Hsie

1979-01-01T23:59:59.000Z

115

Effects of Carbon Nanotubes in Barrier Epithelial Cells via Effects on Lipid Bilayers Shanta Lewis1  

E-Print Network (OSTI)

Effects of Carbon Nanotubes in Barrier Epithelial Cells via Effects on Lipid Bilayers Shanta Lewis1 Physiology, IU School of Medicine Carbon nanotubes (CNTs) are one of many nanoparticles (NP) which are being

Zhou, Yaoqi

116

Characterization of an Epithelial and a Tumor-associated Human Small Cell Lung Carcinoma Glycoprotein Antigen  

Science Journals Connector (OSTI)

...beled membrane proteins has led to the hope of many investi gators that their antibodies might be directed against such a protein...blood group determinant have been reported by other investi gators. Examples in other respiratory tract tumors include antibodies...

Robert Waibel; Carl J. O'Hara; Rolf A. Stahel

1987-07-15T23:59:59.000Z

117

Classification of Human Epithelial Type 2 Cell Indirect Immunofluoresence Images via Codebook Based Descriptors  

E-Print Network (OSTI)

, Australia Sullivan Nicolaides Pathology, Australia Abstract The Anti-Nuclear Antibody (ANA) clinical of several vari- ants of the descriptor on two publicly available datasets: ICPR HEp-2 cell classification contest dataset and the new SNPHEp-2 dataset. To our knowledge, this is the first time codebook

Sanderson, Conrad

118

Ionizing Radiation Induces a Transient Increase in Cytosolic Free [Ca2+] in Human Epithelial Tumor Cells  

Science Journals Connector (OSTI)

...MDA-MB-231 and HT-29 cells, oscillations in cytosolic [Ca2i@ levels...microscope was used with a 75 W Xenon arc, Nikon UVF 40X (numerical...mm was observed as well as oscillations with a period of 2.8 0...the responders by multiple oscillations in [Ca2@] . . . . . As...

Daniel G. Todd and Ross B. Mikkelsen

1994-10-01T23:59:59.000Z

119

Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer  

Science Journals Connector (OSTI)

...Molecular Targets, and Chemical Biology Nanoparticle Targeting of Anticancer Drug Improves...14263. Prior studies suggested that nanoparticle drug delivery might improve the therapeutic...responses not possible with a free drug. Nanoparticle|drug delivery|PAMAM dendrimer...

Jolanta F. Kukowska-Latallo; Kimberly A. Candido; Zhengyi Cao; Shraddha S. Nigavekar; Istvan J. Majoros; Thommey P. Thomas; Lajos P. Balogh; Mohamed K. Khan; James R. Baker, Jr.

2005-06-15T23:59:59.000Z

120

Abstract B41: Depleted uranium-induced oxidative stress in human bronchial epithelial cells  

Science Journals Connector (OSTI)

...Science of Cancer Health Disparities- Feb...AZ Abstract B41: Depleted uranium-induced oxidative...Science of Cancer Health Disparities- Feb...high deposits of uranium or tailings. There...occupational exposures to depleted uranium via military...

Monica Yellowhair; Leigh A. Henricksen; Aneesha Hossain; Kathleen Dixon; and R. Clark Lantz

2009-02-01T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Abstract B41: Depleted uranium-induced oxidative stress in human bronchial epithelial cells  

Science Journals Connector (OSTI)

...Association for Cancer Research 1 February...The Science of Cancer Health Disparities...Abstract B41: Depleted uranium-induced oxidative...Carefree, AZ Cancer and mortality...deposits of uranium or tailings...exposures to depleted uranium via...

Monica Yellowhair; Leigh A. Henricksen; Aneesha Hossain; Kathleen Dixon; and R. Clark Lantz

2009-02-01T23:59:59.000Z

122

Abstract B41: Depleted uranium-induced oxidative stress in human bronchial epithelial cells  

Science Journals Connector (OSTI)

...Carefree, AZ Abstract B41: Depleted uranium-induced oxidative stress in...as occupational exposures to depleted uranium via military action. Cellular...to evaluate the toxicity of depleted uranium (DU) in its soluble and insoluble...

Monica Yellowhair; Leigh A. Henricksen; Aneesha Hossain; Kathleen Dixon; and R. Clark Lantz

2009-02-01T23:59:59.000Z

123

Oncogenic manipulation and biologic selection for complete tumorigenic transformation of immortalized normal human bronchial epithelial cells  

Science Journals Connector (OSTI)

...manipulation soft agar colony forming efficiency (CFE) was 0.1%. With various oncogenic manipulations...higher KRASV12 and p53 knockdown increased CFE to 8%. None of these were tumorigenic...colonies were isolated and found to have CFE of 1015% with large colony numbers increased...

Mitsuo Sato; Woochang Lee; Luc Girard; Ruben D. Ramirez; David S. Shames; Adi F. Gazdar; Jerry W. Shay; John D. Minna

2006-04-15T23:59:59.000Z

124

Effect of Phorbol Esters on Clonal Cultures of Human, Hamster, and Rat Respiratory Epithelial Cells  

Science Journals Connector (OSTI)

...PDD, phorbol-12,13-didecanoate; CFE, colony-forming efficiency (the percent...scored under a dissecting micro scope and the CFE was calculated for each replicate. The...concentration of 30 nM or higher. The maximal CFE seen was 10-fold over control. CFE of...

Diane K. Beeman; Jill M. Siegfried; Marc J. Mass

1987-01-15T23:59:59.000Z

125

Using ex vivo organ culture models as surrogates to investigate morphological and functional differences of mammary glands derived from mouse strains that differ in cancer susceptibility to understand the underlying mechanisms of radiation sensitivity or resistance  

NLE Websites -- All DOE Office Websites (Extended Search)

ex vivo organ culture models as surrogates to investigate morphological and functional ex vivo organ culture models as surrogates to investigate morphological and functional differences of mammary glands derived from mouse strains that differ in cancer susceptibility to understand the underlying mechanisms of radiation sensitivity or resistance Alvin Lo, Joni D. Mott, Jian-Hua Mao, and Mina J. Bissell Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley CA 94720 Goal: Within the Lawrence Berkeley National Laboratory's Low Dose SFA, as part of Project 2, we are using a systems genetics approach to determine the contribution of non-targeted and targeted radiation effects for risk of mammary carcinogenesis. The goal of this work is to characterize the mammary gland of the parental mouse strains, and the F1 and F2 generations used in these studies with respect to tissue

126

In vitro models for airway epithelial cell culture  

E-Print Network (OSTI)

This work is about the development of a physiologically relevant model of the human airway. Various factors such as the cell model, physiochemical factors such as the cell substrate properties including its stiffness, shear ...

Sivathanu, Vivek

2013-01-01T23:59:59.000Z

127

Mechanisms of lead transport in two intestinal epithelial cell lines  

E-Print Network (OSTI)

recognized for as long as Pb has been used in society; however, Pb toxicity is still a problem today in humans and animals. Human exposure to Pb can occur by inhalation of Pb-contaminated dust, or more commonly, by ingesting Pb-contaminated water, food... to adults, children and young animals absorb greater amounts of a given dose of Pb; however, the reason for the increased absorption and the mechanisms by which Pb is absorbed in the immature gut are unclear. Using suckling and weanling rats, Henning...

Dekaney, Christopher Matthew

2012-06-07T23:59:59.000Z

128

A Role for ZO-1 and PLEKHA7 in Recruiting Paracingulin to Tight and Adherens Junctions of Epithelial Cells*S  

E-Print Network (OSTI)

of Epithelial Cells*S Received for publication,February 14, 2011, and in revised form, March 17, 2011 Published

Halazonetis, Thanos

129

Berthon P, Katoh M, Dusanter-Fourt 1, Kelly PA, Djiane J, 1986b. Purification of prolactin receptor from sow mam-mary gland and polyclonal antibodies production. Mol Cell Endocrinol, soumis publication  

E-Print Network (OSTI)

Berthon P, Katoh M, Dusanter-Fourt 1, Kelly PA, Djiane J, 1986b. Purification of prolactin receptor publication Djiane J, Durand P, Kelly PA, 1977. Evolution of prolactin receptors in rabbit mammary gland during pregnancy and lactation. Endocrinology, 100:1348-1356 Djiane J, Dusanter-Fourt 1, Katoh M, Kelly

Paris-Sud XI, Université de

130

Inhibition of 7,12-Dimethylbenz(a)anthracene-induced Tumors and DNA Adduct Formation in the Mammary Glands of Female Sprague-Dawley Rats by the Synthetic Organoselenium Compound, 1,4-Phenylenebis(methylene)selenocyanate  

Science Journals Connector (OSTI)

...terminated 16 wk later. The development of mammary tumors in...1 can inhibit tumor development induced by chemical...3.1.21.1), snake venom phosphodiesterase...in the diet at room temperature and at 4'C was confirmed...for 20 min at room temperature. The residual food...

Karam El-Bayoumy; Young-Heum Chae; Pramod Upadhyaya; Carol Meschter; Leonard A. Cohen; and Bandaru S. Reddy

1992-05-01T23:59:59.000Z

131

Human Ecology Human ecology Research  

E-Print Network (OSTI)

Human Ecology Impact of Human ecology Research Bonus Issue FROM SCHOLARSHIP TO POLICY MAKING OF HUMAN ECOLOGY APRIL 2005/VOLUME 33, NUMBER 1 #12;Human Ecology Volume 33, Number 1 April 2005 The New York State College of Human Ecology at Cornell University Lisa Staiano-Coico, Ph.D. Rebecca Q

Wang, Z. Jane

132

Delineation of the Key Aspects in the Regulation of Epithelial Monolayer Formation  

Science Journals Connector (OSTI)

...oxygen and 37C in a 5% CO2 humidified atmosphere. Dishes were sealed with PetriSeal adhesive...homo-cis-interactions within its own cell plasma membrane. The combination of trans and...Epithelial cell-cell junctions and plasma membrane domains. Biochim. Biophys...

Lydia Aschauer; Leonhard N. Gruber; Walter Pfaller; Alice Limonciel; Toby J. Athersuch; Rachel Cavill; Abdulhameed Khan; Gerhard Gstraunthaler; Johannes Grillari; Regina Grillari; Philip Hewitt; Martin O. Leonard; Anja Wilmes; Paul Jennings

2013-04-22T23:59:59.000Z

133

Delineation of the Key Aspects in the Regulation of Epithelial Monolayer Formation  

Science Journals Connector (OSTI)

...homo-cis-interactions within its own cell plasma membrane. The combination of trans and...proximal-tubule phenotype. Published ahead of print 22 April 2013 ACKNOWLEDGMENTS: This work...Epithelial cell-cell junctions and plasma membrane domains. Biochim. Biophys...

Lydia Aschauer; Leonhard N. Gruber; Walter Pfaller; Alice Limonciel; Toby J. Athersuch; Rachel Cavill; Abdulhameed Khan; Gerhard Gstraunthaler; Johannes Grillari; Regina Grillari; Philip Hewitt; Martin O. Leonard; Anja Wilmes; Paul Jennings

2013-04-22T23:59:59.000Z

134

The amniote primitive streak is defined by epithelial cell intercalation before gastrulation  

E-Print Network (OSTI)

During gastrulation, a single epithelial cell layer, the ectoderm, generatestwoothers (Gallus gallus) embryos, we reveal a medio-lateral cell intercalation confined to the ectodermal subdomain movements of the mesoderm described in fish and amphibians (anamniotes)4­8 : it occurs before gastrulation

Stern, Claudio

135

The FASEB Journal Research Communication Calmodulin-dependent activation of the epithelial  

E-Print Network (OSTI)

calcium-dependent chloride channel TMEM16A Yuemin Tian,* Patthara Kongsuphol,* Martin Hug, Jiraporn-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A. FASEB J. 25, 1058­1068 (2011). www 1­10). TMEM16A has 8 putative transmembrane do- mains (TMDs) and a p-loop between TMD 5 and TMD 6

Witzgall, Ralph - Naturwissenschaftliche Fakultät III

136

Organotypic Epithelial Raft Cultures as a Model for Evaluating Compounds against Alphaherpesviruses  

Science Journals Connector (OSTI)

...cultured in a three-dimensional organotypic raft...the air-liquid interface stratified and...the air-liquid interface. For VZV, the...accomplished by measuring viral titers by...for HSV and by measuring viral DNA load...demonstrated The three-dimensional epithelial raft...

Graciela Andrei; Joost van den Oord; Pierre Fiten; Ghislain Opdenakker; Chris De Wolf-Peeters; Erik De Clercq; Robert Snoeck

2005-11-01T23:59:59.000Z

137

Modeling gas phase nitric oxide release in lung epithelial cells Jingjing Jiang a  

E-Print Network (OSTI)

Modeling gas phase nitric oxide release in lung epithelial cells Jingjing Jiang a , Steven C- dated our model with experimental results of gas phase NO release and intracellular L enzyme on NO production. Our model predicts intracellular L-arginine and gas phase NO release over a wide

George, Steven C.

138

Cable-Piliated Burkholderia cepaciaBinds to Cytokeratin 13 of Epithelial Cells  

Science Journals Connector (OSTI)

...ARTICLE MOLECULAR AND CELLULAR PATHOGENESIS Cable-Piliated Burkholderia cepacia Binds to...Canada. This strain expresses surface cable (Cbl) pili and is thought to be the major...epithelial cell (BEC) protein that binds cable pilus-positive B. cepacia. N-terminal...

Umadevi S. Sajjan; Francisco A. Sylvester; Janet F. Forstner

2000-04-01T23:59:59.000Z

139

Low Dose Radiation Research Program: Multi-cellular Crosstalk in Radiation  

NLE Websites -- All DOE Office Websites (Extended Search)

About this Project About this Project Multi-cellular Crosstalk in Radiation Damage Technical Abstracts 2006 Workshop: Low-LET Bystander Effects in Cells In Vitro Are Significantly Less Than Published For High-LET Radiation Blakely, E.A., Thompson, A.C., Chang, P., Schwarz, R.I., Bjornstad, K., Rosen, C., Wisnewski, C., and Mocherla, D. 2005 Workshop: X-ray Microbeam Bystander Studies with Human Mammary Epithelial Cells and Fibroblasts Blakely, E.A., Schwarz, R.I., Thompson, A.C., Bjornstad, K.A., Chang, P.Y., Rosen, C.J., Sudar, D., Romano, R., and Parvin, B. 2003 Workshop: 12.5 keV X-ray Microbeam Bystander Studies with Human Mammary Epithelial Cells and Fibroblasts Blakely, E.A., Schwarz, R.I., Thompson, A.C., Bjornstad, K.A., Chang, P.Y., Rosen, C.J., and Sudar, D. 2001 Workshop:

140

Lack of Tumorigenicity of Cholesterol Epoxides and Estrone-3,4-quinone in the Rat Mammary Gland  

Science Journals Connector (OSTI)

...in human breast fluid and in plasma are potential initiators of...in human breast fluid and in plasma are poten tial initiators of...60 ml) at " -30 Cunder N, atmosphere. The reaction was complete...previously (20, 21); (360 MHz, CDC1,) 0.93 (s, 3H...

Karam El-Bayoumy; Ben-Yi Ji; Pramod Upadhyaya; Young-Heum Chae; Christine Kurtzke; Abraham Rivenson; Bandaru S. Reddy; Shantu Amin; and Stephen S. Hecht

1996-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

The Staphylococcus aureus Alpha-Toxin Perturbs the Barrier Function in Caco-2 Epithelial Cell Monolayers by Altering Junctional Integrity  

Science Journals Connector (OSTI)

...equipped for epifluorescence with a 75-W xenon arc lamp and a 100 glycerol immersion...Meldolesi J . 1998. Calcium signaling: oscillation, activation, expression. Nature 392...uropathogenic E. coli induces Ca2+ oscillations in renal epithelial cells. Nature 405...

Young-Keun Kwak; Elena Vikstrm; Karl-Eric Magnusson; Beatrix Vcsey-Semjn; Patricia Colque-Navarro; Roland Mllby

2012-02-21T23:59:59.000Z

142

A Congenic Line of the BALB/c Mouse Strain with the Endogenous Mouse Mammary Tumor Virus Proviral Gene Mtv-3: Tissue-specific Expression and Correlation with Resistance to Mouse Mammary Tumor Virus Infection and Tumorigenesis  

Science Journals Connector (OSTI)

...N-methyl-N-nitro-N-nitrosoguanidine by three exposure routes at different developmental...12-dimethylbenzanthracene by two exposure routes at different developmental...human rhabdomyosarcoma cell lines and tumour samples. J Pathol...pancreatic origin for the tumor. Transmission electron microscopy revealed...

Pierre Hainaut; Marc Castellazzi; Dominique Gonzales; Nathalie Clausse; Jo Hilgers; and Michel Crpin

1990-06-15T23:59:59.000Z

143

Evaluation of Common Angling-Induced Sources of Epithelial Damage for Popular Freshwater Sport Fish using Fluorescein  

SciTech Connect

Angling is a popular recreational activity across the globe and a large proportion of fish captured by anglers are released due to voluntary or mandatory catch-and-release practices. The handling associated with hook removal and return of the fish to their environment can cause physical damage to the epidermal layer of the fish which may affect the condition and survival of released fish. This study investigated possible sources of epithelial damage associated with several different handling methods (i.e. landing net types, interactions with different boat floor surfaces, tournament procedures) commonly used in recreational angling for two popular freshwater sport fish species, largemouth bass (Micropterus salmoides) and northern pike (Esox lucius). Epithelial damage was examined using fluorescein, a non-toxic dye, which has been shown to detect latent epithelial damage. Northern pike exhibited extensive epithelial damage after exposure to several of the induced treatments (i.e., interaction with a carpeted surface, knotted nylon net, and line rolling) but relatively little epithelial damage when exposed to others (i.e., knotless rubber nets, smooth boat surfaces, or lip gripping devices). Largemouth bass did not show significant epithelial damage for any of the treatments, with the exception of fish caught in a semi-professional live release tournament. The detection of latent injuries using fluorescein can be an important management tool as it provides visual examples of potential damage that can be caused by different handling methods. Such visualizations can be used to encourage fish friendly angler behaviour and enhance the survival and welfare of released fish. It can also be used to test new products that are intended to or claim to reduce injury to fish that are to be released. Future research should evaluate the relationship between different levels of epithelial damage and mortality across a range of environmental conditions.

Colotelo, Alison HA; Cooke, Steven J.

2011-05-01T23:59:59.000Z

144

A Critical Examination of the Adaptive Response for Cytogenetic Damagein Human Cells, and Insights into the Adaptive Response Mechanism  

NLE Websites -- All DOE Office Websites (Extended Search)

Critical Examination of the Adaptive Response for Cytogenetic Damage Critical Examination of the Adaptive Response for Cytogenetic Damage in Human Cells, and Insights into the Adaptive Response Mechanism Björn E. Rydberg, Torsten Groesser, Antoine Snijders, Kelly Trego, Ju Han, Do Yup Lee, Bahram Parvin, Trent Northen, Andrew J. Wyrobek, and Priscilla K. Cooper Berkeley Lab SFA P.I.: Gary Karpen Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 Goal: Task 1 of the Berkeley Lab SFA is designed to identify adaptive response (AR) mechanisms that may affect risk of developing radiation-induced cancer and to assess the linearity with dose of processes that influence mammary gland carcinogenesis. We use both in vitro and in vivo experimental systems in a parallelogram strategy. Our human cell culture

145

Comparative Evaluation of Four Presumptive Tests for Blood to Detect Epithelial Injury on Fish  

SciTech Connect

Current methods of fish epithelial injury detection are limited to gross macroscopic examination that has a subjective bias as well as an inability to reliably quantify the degree of injury. Fluorescein, a presumptive test for blood, has been shown to have the capability to detect and quantify fish epithelial injury. However, there are several other presumptive tests for blood (Bluestar*, phenolphthalein, and HemastixH) that may have benefits over the use of fluorescein, particularly for field research on wild fish. This study investigated the capabilities of these four tests to detect and quantify a variety of injuries commonly encountered by fish (abrasion, cuts, fin frays, and punctures) using the freshwater bluegill Lepomis macrochirus as a model. Fluorescein was consistently found to be the most reliable (i.e., detected the highest proportion of true positive results and rarely detected false positive reactions) of the four presumptive tests for blood compared. Further testing was conducted to examine the reliability of fluorescein. By 24 h after an injury was inflicted, the injury was no longer detectable by fluorescein, and when fluorescein was applied to an injured fish, the fluorescein was no longer detectable 3 h after application. In a comparison of two common anaesthetics used in fisheries research, there was no significant difference in the proportion of injury detected when 3- aminobenzoic acid ethyl ester methanesulfate (tricaine) was used compared with a clove oil and ethanol (1:9) solution. In summary, fluorescein was the most reliable presumptive test for blood examined in this study for the detection and quantification of recent (hours) fish epithelial injury.

Colotelo, Alison HA; Smokorowski, Karen; Haxton, Tim; Cooke, Steven J.

2014-06-01T23:59:59.000Z

146

Low Dose Radiation Research Program: 12.5 keV Xray Microbeam Bystander  

NLE Websites -- All DOE Office Websites (Extended Search)

12.5 keV Xray Microbeam Bystander Studies With Human Mammary 12.5 keV Xray Microbeam Bystander Studies With Human Mammary Epithelial Cells and Fibroblasts Authors: E. A. Blakely1, R. I. Schwarz1, A. C. Thompson2, K. A. Bjornstad1, P. Y. Chang1,3 C.J. Rosen1, and D. Sudar1 Institutions: Divisions of 1Life Sciences and 2Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA. and 3SRI International, Menlo Park, CA. We are using a novel x-ray Microprobe Beamline at the Advanced Light Source (ALS) at LBNL to investigate bystander effects of low doses in well characterized human mammary epithelial cells (HMEC) and human skin fibroblasts (HSF). The ALS facility is capable of producing a beam of 12.5 keV x-rays with a focussed spot size of __m_ and a wide range of doses and dose-rates. Unlike normal x-ray sources, this beam has a very small background of either low-

147

Abstract 276: Appalachian mountaintop mining particulate matter induces malignant transformation and tumorigenesis of human lung epithelial cells  

Science Journals Connector (OSTI)

...276: Appalachian mountaintop mining particulate matter induces malignant...Virginia (WV), the biggest coal mining state in Appalachia, ranks the third highest rate...that living near WV mountaintop coal mining (MTM) activities is a contributing...

Sudjit Luanpitpong; Juhua Luo; Travis Kneuckles; Michael Hendryx; and Yon Rojanasakul

2014-10-01T23:59:59.000Z

148

Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress  

Science Journals Connector (OSTI)

...Jr. ( 2003 ) J. Neurochem. 87 , 297 -309. 14511107 8 Wheeler, T. G., Benolken, R. M. & Anderson, R. E...Leicester, U.K.) for the lentivirus construct, and to Katherine Gotlinger for expert technical assistance. This work was supported...

Pranab K. Mukherjee; Victor L. Marcheselli; Charles N. Serhan; Nicolas G. Bazan

2004-01-01T23:59:59.000Z

149

Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells  

Science Journals Connector (OSTI)

Roles of pilin and PilC in adhesion of Neisseria meningitidis to...adhesiveness of strain 8013. Roles of pilin and PilC in adhesion of Neisseria meningitidis to...Bacterial Proteins 0 Oligonucleotide Probes 0 pilC protein, Neisseria gonorrhoeae 147680-16-8...

X Nassif; J L Beretti; J Lowy; P Stenberg; P O'Gaora; J Pfeifer; S Normark; M So

1994-01-01T23:59:59.000Z

150

Neisseria gonorrhoeae PilV, a type IV pilus-associated protein essential to human epithelial cell adherence  

Science Journals Connector (OSTI)

...virtue of the associated adhesin protein PilC. To examine the structural and functional...PilE and copurifies with Tfp fibers in a PilC-dependent fashion. Purified Tfp from pilV mutants contain PilC adhesin at reduced levels. Taken together...

Hanne C. Winther-Larsen; Finn Terje Hegge; Matthew Wolfgang; Stanley F. Hayes; Jos P. M. van Putten; Michael Koomey

2001-01-01T23:59:59.000Z

151

Abstract 3464: Epigenetic mechanism is involved in depleted uranium-induced transformation in human lung epithelial cells  

Science Journals Connector (OSTI)

...Association for Cancer Research 15 April...Abstract 3590: Depleted uranium-induced leukemia...development. Depleted uranium is used in military...Max Costa. Depleted uranium-induced leukemia...Association for Cancer Research; 2013...

Hong Xie; Carolyne LaCerte; and John P. Wise

2010-04-15T23:59:59.000Z

152

Neoplastic Transformation of a Human Colonic Epithelial Cell Line: In Vitro Evidence for the Adenoma to Carcinoma Sequence  

Science Journals Connector (OSTI)

...AA/C1 [colony-forming efficiency (CFE) on plastic of 1.05%] was isolated...C1/SB cell line which had an increased CFE on plastic (6.13%) although the cells...On continuous in vitro passage, the CFE in agarose of AA/C1/SB10 has increased...

Ann C. Williams; Sara J. Harper; Christos Paraskeva

1990-08-01T23:59:59.000Z

153

Differential expression of MHC class II antigens and cathepsin L by subtypes of cortical epithelial cells in the rat thymus: an immunoelectron microscopic study  

Science Journals Connector (OSTI)

......3 de Waal E J and Rademakers L H P M (1997) Heterogeneity of epithelial cells in the...40 van de Wijngaert F P, Kendall M D, Schuurman H J, Rademakers L H P M, and Kater L (1984) Heterogeneity of epithelial......

Yamini Arudchelvan; Yukio Nishimura; Nobuko Tokuda; Tomoo Sawada; Fumihiko Shinozaki; Tetsuo Fukumoto

2002-05-01T23:59:59.000Z

154

Human Nature  

Science Journals Connector (OSTI)

In the human enhancement debate, both parties advocate a partial truth. On the one hand, the bioconservatives argue that, if transhumanism is unleashed without some kind of bioethical...have (A+) is itself a prod...

Prof.; Dr. Hub Zwart

2014-08-01T23:59:59.000Z

155

Human Enhancement  

Science Journals Connector (OSTI)

Abstract Categorizing different human enhancements into personal, social, or species enhancements, as well as considering whether a particular enhancement technique generates asymmetric or network benefits, brings clarity to discussions about the ethical issues pertaining to any individual technique. The four aspects of principlism can help to assess the ethical implications of different human enhancements, revealing complexities in their aspirational claims for personally directed self-development. At a practical level, this article examines important questions about real expectations, scientific hubris, and hype.

P. Moore

2012-01-01T23:59:59.000Z

156

Acrolein generation stimulates hypercontraction in isolated human blood vessels  

SciTech Connect

Increased risk of vasospasm, a spontaneous hyperconstriction, is associated with atherosclerosis, cigarette smoking, and hypertension-all conditions involving oxidative stress, lipid peroxidation, and inflammation. To test the role of the lipid peroxidation- and inflammation-derived aldehyde, acrolein, in human vasospasm, we developed an ex vivo model using human coronary artery bypass graft (CABG) blood vessels and a demonstrated acrolein precursor, allylamine. Allylamine induces hypercontraction in isolated rat coronary artery in a semicarbazide-sensitive amine oxidase activity (SSAO) dependent manner. Isolated human CABG blood vessels (internal mammary artery, radial artery, saphenous vein) were used to determine: (1) vessel responses and sensitivity to acrolein, allylamine, and H{sub 2}O{sub 2} exposure (1 {mu}M-1 mM), (2) SSAO dependence of allylamine-induced effects using SSAO inhibitors (semicarbazide, 1 mM; MDL 72274-E, active isomer; MDL 72274-Z, inactive isomer; 100 {mu}M), (3) the vasoactive effects of two other SSAO amine substrates, benzylamine and methylamine, and (4) the contribution of extracellular Ca{sup 2+} to hypercontraction. Acrolein or allylamine but not H{sub 2}O{sub 2}, benzylamine, or methylamine stimulated spontaneous and pharmacologically intractable hypercontraction in CABG blood vessels that was similar to clinical vasospasm. Allylamine-induced hypercontraction and blood vessel SSAO activity were abolished by pretreatment with semicarbazide or MDL 72274-E but not by MDL 72274-Z. Allylamine-induced hypercontraction also was significantly attenuated in Ca{sup 2+}-free buffer. In isolated aorta of spontaneously hypertensive rat, allylamine-induced an SSAO-dependent contraction and enhanced norepinephrine sensitivity but not in Sprague-Dawley rat aorta. We conclude that acrolein generation in the blood vessel wall increases human susceptibility to vasospasm, an event that is enhanced in hypertension.

Conklin, D.J. [Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202 (United States) and Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, WI 54701 (United States)]. E-mail: dj.conklin@louisville.edu; Bhatnagar, A. [Institute of Molecular Cardiology, Department of Medicine, University of Louisville, Louisville, KY 40202 (United States); Cowley, H.R. [Department of Biology, University of Wisconsin-Eau Claire, Eau Claire, WI 54701 (United States); Johnson, G.H. [Department of Cardiothoracic Surgery, Luther Hospital/Midelfort Clinic, Eau Claire, WI 54702 (United States); Wiechmann, R.J. [Department of Cardiothoracic Surgery, Luther Hospital/Midelfort Clinic, Eau Claire, WI 54702 (United States); Sayre, L.M. [Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 (United States); Trent, M.B. [Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555-0609 (United States); Boor, P.J. [Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, TX 77555-0609 (United States)

2006-12-15T23:59:59.000Z

157

Cell-cycle dependent localization of MELK and its new partner RACK1 in epithelial versus mesenchyme-like  

E-Print Network (OSTI)

Cell-cycle dependent localization of MELK and its new partner RACK1 in epithelial versus mesenchyme. Receptor for Activated protein Kinase C (RACK1), which we identified as an xMELK partner, co-localizes with xMELK at the tight junction. Moreover, a truncated RACK1 construct interferes with i

Paris-Sud XI, Université de

158

3624 Biophysical Journal Volume 84 June 2003 36243635 Discrete Models of Autocrine Cell Communication in Epithelial Layers  

E-Print Network (OSTI)

of Chemical Engineering and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton-to- cell communication produces spatially nonuniform patterns in the expression of genes that guide the development of tissues and organs. The design principles of epithelial patterning are being formulated only

Shvartsman, Stanislav "Stas"

159

Biological Basis for Radiation Adaptive Responses that Protect Against Bronchial Epithelial Cell Transformation  

NLE Websites -- All DOE Office Websites (Extended Search)

Basis for Radiation Adaptive Responses that Protect Against Bronchial Basis for Radiation Adaptive Responses that Protect Against Bronchial Epithelial Cell Transformation Wenshu Chen, Xiuling Xu, Lang Bai, Mabel T. Padilla, Carmen Tellez, Katherine M. Gott, Shuguang Leng, Julie A. Wilder, Steven A. Belinsky, Bobby R. Scott and Yong Lin, Lovelace Respiratory Research Institute, 2425 Ridgecrest Drive SE, Albuquerque, NM 87108 The major hypothesis in this project is that low-dose, low linear-energy-transfer (LET) radiation stimulates an adaptive response that protects cells from neoplastic transformation involving modulation of paracrine factors (e.g., cytokines), cell survival/death signaling pathways, and reprogramming of the epigenome. To test this hypothesis, a validated, sensitive in vitro transformation model and a media transfer

160

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures  

SciTech Connect

Bin/amphipysin/Rvs (BAR)-domain proteins sculpt cellular membranes and have key roles in processes such as endocytosis, cell motility and morphogenesis. BAR domains are divided into three subfamilies: BAR- and F-BAR-domain proteins generate positive membrane curvature and stabilize cellular invaginations, whereas I-BAR-domain proteins induce negative curvature and stabilize protrusions. We show that a previously uncharacterized member of the I-BAR subfamily, Pinkbar, is specifically expressed in intestinal epithelial cells, where it localizes to Rab13-positive vesicles and to the plasma membrane at intercellular junctions. Notably, the BAR domain of Pinkbar does not induce membrane tubulation but promotes the formation of planar membrane sheets. Structural and mutagenesis analyses reveal that the BAR domain of Pinkbar has a relatively flat lipid-binding interface and that it assembles into sheet-like oligomers in crystals and in solution, which may explain its unique membrane-deforming activity.

Pyklinen, Anette; Boczkowska, Malgorzata; Zhao, Hongxia; Saarikangas, Juha; Rebowski, Grzegorz; Jansen, Maurice; Hakanen, Janne; Koskela, Essi V.; Pernen, Johan; Vihinen, Helena; Jokitalo, Eija; Salminen, Marjo; Ikonen, Elina; Dominguez, Roberto; Lappalainen, Pekka (Helsinki); (Penn)

2013-05-29T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Transcription of the Tollip gene is elevated in intestinal epithelial cells through impaired O-GlcNAcylation-dependent nuclear translocation of the negative regulator Elf-1  

SciTech Connect

Highlights: {yields} Transcriptional activation of the Tollitip gene is higher in IECs than in monocytes. {yields} Nt -194/-186 region acts as a cis-element and is recognized by Elf-1. {yields} Elf-1 suppresses Tollip gene transcription in monocytes but not in IECs. {yields} O-GlcNAc modification is necessary for nuclear translocation of Elf-1. {yields} O-GlcNAcylation-dependent nuclear translocation of Elf-1 is impaired in IECs. -- Abstract: Intestinal epithelial cells (IECs) must be tolerant of the large number of commensal bacteria inhabiting the intestinal tract to avoid excessive inflammatory reactions. Toll-interacting protein (Tollip), a negative regulator of Toll-like receptor signaling, is known to be expressed at high levels in IECs, and to thereby contribute to the hyporesponsiveness of IECs to commensals. In this study, we analyzed the underlying mechanisms for elevated transcription of the Tollip gene in IECs using a human IEC line, Caco-2, and a human monocyte line, THP-1, as a control. Elf-1 was identified as a transcription factor that negatively regulates Tollip gene expression. The transcription factor Elf-1 was localized in the nucleus by O-linked N-acetylglucosamine (O-GlcNAc) modification, whereas the unmodified form was detected only in the cytoplasm. Comparison of Caco-2 and THP-1 cells revealed that O-GlcNAc modification of Elf-1 was significantly lower in IECs than in monocytes. Collectively, the results indicate that insufficient O-GlcNAc modification prevents Elf-1-mediated transcriptional repression and thereby upregulates Tollip gene expression in IECs.

Sugi, Yutaka [College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880 (Japan)] [College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880 (Japan); Takahashi, Kyoko, E-mail: ktaka@brs.nihon-u.ac.jp [College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880 (Japan)] [College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880 (Japan); Nakano, Kou; Hosono, Akira; Kaminogawa, Shuichi [College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880 (Japan)] [College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880 (Japan)

2011-09-09T23:59:59.000Z

162

A link between stem cells and the EMT phenotype induced by IR and TGFβ  

NLE Websites -- All DOE Office Websites (Extended Search)

link between stem cells and the EMT phenotype induced by IR and TGFβ link between stem cells and the EMT phenotype induced by IR and TGFβ Ignacio Fernandez-Garcia New York University School of Medicine Abstract Epithelial-Mesenchymal Transition (EMT) occurs as key developmental program but is also often activated during cancer progression. EMT is characterized by loss of epithelial cell polarity, loss of cell-cell contacts, and acquisition of mesenchymal markers and phenotypic traits that include increased cell motility1. Approximately 18% of breast cancers exhibit evidence of EMT. We have shown that the progeny of irradiated human mammary epithelial cells (HMEC) undergo EMT when exposed to transforming growth factor β1 (TGFβ). Additionally, recent publication from Weinberg and colleagues showed that induction of EMT through engineered expression of

163

Berkeley Lab A to Z Index: M  

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Macintosh Computer Backups Macintosh Computer Backups Macintosh User Group (LBNL-MUG) Mac support/MPSG (formerly known as the workstation group) Macromolecular Crystallography Facility (MCF) Mailing Addresses for Lab Mail (electronic); Email Support, Documentation, etc. Mail Services (Facilities Dep't.) malware (computer virus) protection and "How to Handle Suspected Malware" Mammary: Human Mammary Epithelial Cell (HMEC) Map: Berkeley Lab Global Talent Map Maps: Directions and Maps on How to Get to the Lab Maps: Berkeley Lab Interactive Site Map Maps: Berkeley Lab Printable Site Map Maps: Offsite Lab Shuttle Bus Map Maps: Onsite Lab Shuttle Bus Map Massage, Onsite Chair Mass Storage System (MSS) Material Safety Data Sheets: MSDS Materials Sciences Division (MSD) Materials Science: Technology Transfer

164

aromatic hydrocarbons coated: Topics by E-print Network  

NLE Websites -- All DOE Office Websites (Extended Search)

Summary: ??Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants, known human lung carcinogens, and potent mammary carcinogens in animal models....

165

Human-machine interactions  

SciTech Connect

Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

Forsythe, J. Chris (Sandia Park, NM); Xavier, Patrick G. (Albuquerque, NM); Abbott, Robert G. (Albuquerque, NM); Brannon, Nathan G. (Albuquerque, NM); Bernard, Michael L. (Tijeras, NM); Speed, Ann E. (Albuquerque, NM)

2009-04-28T23:59:59.000Z

166

High LET radiatSpace Radiation Can Enhance the TGFβ InducedEpithelial-Mesenchymal Transitionion can enhance TGFβ induced EMT and cross-talk with ATM pathways  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation Can Enhance the TGFβ Induced Radiation Can Enhance the TGFβ Induced Epithelial-Mesenchymal Transition Minli Wang 1 , Megumi Hada 1 , Janice Huff 1 , Janice M. Pluth 2 , Jennifer Anderson 3 , Peter O'Neill 3 and Francis A. Cucinotta 4 1 USRA Division of Life Sciences, Houston TX USA; 2 Lawrence Berkeley National Laboratory, Berkeley CA, USA, 3 Gray Institute for Radiation Oncology & Biology, University of Oxford, UK, 4 NASA, Lyndon B. Johnson Space Center, Houston TX, USA TGFβ is a key modulator of the Epithelial-Mesenchymal Transition (EMT), important in cancer progression and metastasis, which involve classic Smad or non-Smad signaling pathways, leading to the suppression of epithelial genes and promoted expression of mesenchymal proteins. Ionizing radiation was found to specifically induce expression of

167

Antigen presentation by small intestinal epithelial cells uniquely enhances IFN-? secretion from CD4{sup +} intestinal intraepithelial lymphocytes  

SciTech Connect

Highlights: Small intestinal epithelial cells (sIECs). sIECs are able to induce antigen specific proliferation of CD4{sup +} IELs. sIECs induce markedly enhanced IFN-? secretion by CD4{sup +} IELs. Induction of enhanced IFN-? secretion by sIECs is uniquely observed in CD4{sup +} IELs. -- Abstract: Small intestinal epithelial cells (sIECs) express major histocompatibility complex class II molecules even in a normal condition, and are known to function as antigen presenting cells (APCs) at least in vitro. These findings raised the possibility that sIECs play an important role in inducing immune responses against luminal antigens, especially those of intestinal intraepithelial lymphocytes (IELs) and lamina propria lymphocytes (LPLs). We herein showed that antigenic stimulation with sIECs induced markedly greater secretion of interferon-gamma (IFN-?) by CD4{sup +} IELs, but not interleukin (IL)-4, IL-10 and IL-17 although the proliferative response was prominently lower than that with T cell-depleted splenic APCs. In contrast, no enhanced IFN-? secretion by CD4{sup +} LPLs and primed splenic CD4{sup +} T cells was observed when stimulated with sIECs. Taken together, these results suggest that sIECs uniquely activate CD4{sup +} IELs and induce remarkable IFN-? secretion upon antigenic stimulation in vivo.

Hatano, Ryo; Yamada, Kiyoshi; Iwamoto, Taku; Maeda, Nana; Emoto, Tetsuro; Shimizu, Makoto; Totsuka, Mamoru, E-mail: atotuka@mail.ecc.u-tokyo.ac.jp

2013-06-14T23:59:59.000Z

168

Cognitive Science (Humanities)  

E-Print Network (OSTI)

Cognitive Science (Humanities) The University of Edinburgh College of Humanities and Social Science: Cognitive Science (Humanities) BSc Honours in: Cognitive Science Please see separate information sheets the disciplines that contribute to the study of human cognition. The Cognitive Science programme at Edinburgh

Schnaufer, Achim

169

The recruitment of stromal cells to the site of tumor formation  

E-Print Network (OSTI)

Myofibroblasts are an alpha-smooth muscle actin ([alpha]-SMA)-expressing cell type found within human mammary carcinomas, but not in the normal mammary gland. Myofibroblasts can enhance tumor formation by promoting ...

Saelzler, Matthew P. (Matthew Paul)

2010-01-01T23:59:59.000Z

170

Final Report: Latent Expression of Genetic Damage in Human Lung Cells  

SciTech Connect

This project was aimed at furthering understanding of the latent effects of ionizing radiation. The underlying premise was that such latent (i.e., delayed) effects stemmed from radiation-induced genetic instability. As model system to investigate certain aspects of genomic instability, they proposed to look at chromosomal instability involving quasi-targeted radiation-induced breakpoints in the vicinity of the HPRT gene in EJ30 human epithelial cells. Using whole chromosome painting of the X chromosome, the authors were able to show that about 15% of randomly selected 6-thioguanine resistant (6TG{prime}) mutants involved translocations in the terminal portion of Xq. Subsequent analysis, using human genomic YAC probes confirmed that all the translocations were either within (or near Xq26.1), the cytogenetic location of HPRT, whereas none were found elsewhere involving the X chromosome.

Cornforth, Michael N.

1999-02-28T23:59:59.000Z

171

Humanitys unsustainable environmental footprint  

Science Journals Connector (OSTI)

...biodiversity loss or effects on human health or...billion m 3 /year (average for 1996 to 2005...billion m 3 /year (average for 1996 to...emissions from fossil fuelspart of humanity...products in their pricefor example, by...The EF of the average global citizen...so-called rebound effect (44). Profound...

Arjen Y. Hoekstra; Thomas O. Wiedmann

2014-06-06T23:59:59.000Z

172

The Potent Carcinogen Dibenzo[a,l]pyrene Is Metabolically Activated to Fjord-Region 11,12-Diol 13,14-Epoxides in Human Mammary Carcinoma MCF-7 Cell Cultures  

Science Journals Connector (OSTI)

...Baird 3 Department of Medicinal Chemistry and Pharmacognosy, Purdue University...addressed, at Department of Medicinal Chemistry, Hansen Life Sciences Research...studies of emissions from unvented coal combustion. Environ. Sci. Technol., 21...

Sherry L. Ralston; Hudson H. S. Lau; Albrecht Seidel; Andreas Luch; Karl L. Platt; and William M. Baird

1994-02-15T23:59:59.000Z

173

Interspecies Differences in the Major DNA Adducts Formed from Benzo(a)pyrene but not 7,12-Dimethylbenz(a)anthracene in Rat and Human Mammary Cell Cultures  

Science Journals Connector (OSTI)

...hydrolysates were applied to Sep-Pak CIS car tridges (Waters Associates, Milford, MA). Unreacted...column was eluted with metha- nol:water (46:54) for 34 min at a flow...relation between carcinogenic power of hydrocarbons and their binding...

Cynthia J. Moore; Donna Pruess-Schwartz; Robert J. Mauthe; Michael N. Gould; and William M. Baird

1987-08-15T23:59:59.000Z

174

Protective effects of pulmonary epithelial lining fluid on oxidative stress and DNA single-strand breaks caused by ultrafine carbon black, ferrous sulphate and organic extract of diesel exhaust particles  

SciTech Connect

Pulmonary epithelial lining fluid (ELF) is the first substance to make contact with inhaled particulate matter (PM) and interacts chemically with PM components. The objective of this study was to determine the role of ELF in oxidative stress, DNA damage and the production of proinflammatory cytokines following physicochemical exposure to PM. Ultrafine carbon black (ufCB, 15 nm; a model carbonaceous core), ferrous sulphate (FeSO{sub 4}; a model transition metal) and a diesel exhaust particle (DEP) extract (a model organic compound) were used to examine the acellular oxidative potential of synthetic ELF and non-ELF systems. We compared the effects of exposure to ufCB, FeSO{sub 4} and DEP extract on human alveolar epithelial Type II (A549) cells to determine the levels of oxidative stress, DNA single-strand breaks and interleukin-8 (IL-8) production in ELF and non-ELF systems. The effects of ufCB and FeSO{sub 4} on the acellular oxidative potential, cellular oxidative stress and DNA single-strand breakage were mitigated significantly by the addition of ELF, whereas there was no decrease following treatment with the DEP extract. There was no significant effect on IL-8 production following exposure to samples that were suspended in ELF/non-ELF systems. The results of the present study indicate that ELF plays an important role in the initial defence against PM in the pulmonary environment. Experimental components, such as ufCB and FeSO{sub 4}, induced the production of oxidative stress and led to DNA single-strand breaks, which were moderately prevented by the addition of ELF. These findings suggest that ELF plays a protective role against PM-driven oxidative stress and DNA damage. -- Highlights: ? To determine the role of ELF in ROS, DNA damage and IL-8 after exposure to PM. ? ufCB, FeSO{sub 4} and DEP extract were used to examine the protective effects of ELF. ? PM-driven oxidative stress and DNA single-strand breakage were mitigated by ELF. ? The findings suggest that ELF has a protective role against PM. ? The synthetic ELF system could reduce the use of animals in PM-driven ROS testing.

Chuang, Hsiao-Chi [School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan (China) [School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan (China); Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan (China); Cheng, Yi-Ling; Lei, Yu-Chen [Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan (China)] [Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan (China); Chang, Hui-Hsien [Institute of Environmental Health, College of Public Health, National Taiwan University, Taipei, Taiwan (China)] [Institute of Environmental Health, College of Public Health, National Taiwan University, Taipei, Taiwan (China); Cheng, Tsun-Jen, E-mail: tcheng@ntu.edu.tw [Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan (China) [Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan (China); Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan (China)

2013-02-01T23:59:59.000Z

175

Programming with human computation  

E-Print Network (OSTI)

Amazon's Mechanical Turk provides a programmatically accessible micro-task market, allowing a program to hire human workers. This has opened the door to a rich field of research in human computation where programs orchestrate ...

Little, Greg (Danny Greg)

2011-01-01T23:59:59.000Z

176

Is humanity sustainable?  

Science Journals Connector (OSTI)

...size, CO2 production, energy use, biomass consumption...Humans| Is humanity sustainable? | The principles and...CO(2) production, energy use, biomass consumption...Resources Ecosystem Energy-Generating Resources...November 2003 Is humanity sustainable? Charles W. Fowler1...

2003-01-01T23:59:59.000Z

177

Human Functional Brain Imaging  

E-Print Network (OSTI)

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review #12;2 | Portfolio Review: Human Functional Brain ImagingThe Wellcome Trust is a charity registered in England and Wales, no's role in supporting human functional brain imaging and have informed `our' speculations for the future

Rambaut, Andrew

178

Biomedical Ethics & Medical Humanities  

E-Print Network (OSTI)

List Sample Elective Courses Arts & Humanities Medical Scholars: Student Projects #12;2 What is BEMHBEMH Biomedical Ethics & Medical Humanities Scholarly Concentration Stanford University School? The Biomedical Ethics and Medical Humanities Scholarly Concentration is part of the new initiative at Stanford

Ford, James

179

Human Genetics Portfolio Review  

E-Print Network (OSTI)

in providing the assessments of the Wellcome Trust's role in supporting human genetics and have informed `our to maximise the health benefits of research into the human genome remains a core component of the WellcomeHuman Genetics 1990­2009 June 2010 Portfolio Review #12;The Wellcome Trust is a charity registered

Rambaut, Andrew

180

Human Research ProgramHuman Research Program Human System Risk in Exploration and  

E-Print Network (OSTI)

Human System Risks in Exploration Missions 21SEP10 2HRP Risk Process ­ D.Grounds Presentation contentsHuman Research ProgramHuman Research Program Human System Risk in Exploration and the Human Research Program 21SEP10 1HRP Risk Process ­ D Grounds #12;Human Research ProgramHuman Research Program

Waliser, Duane E.

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Prolonged Binding of a Radiolabeled Monoclonal Antibody (B72.3) Used for the in Situ Radioimmunodetection of Human Colon Carcinoma Xenografts  

Science Journals Connector (OSTI)

...80% of the colon carcinomas tested but does not react appreciably with normal mammary...80% of the colon carcinomas tested but does not react appre ciably with normal mammary...M. Aloj and L. D. Kohn, (eds.), Handbook on Receptor Research;Thyrothropin Receptors...

David Colcher; Andrew M. Keenan; Steven M. Larson; and Jeffrey Schlom

1984-12-01T23:59:59.000Z

182

Dutch Human Geography  

Science Journals Connector (OSTI)

Human geography in the Dutch academia distinguishes itself from human geography in other continental European countries. It has developed a strong applied focus and an orientation which forms a bridge between continental European approaches in human Geography and the Anglo-Saxon human geography. The motor of this development has been the rivalry between the Amsterdam School of Sociography and the more French oriented Utrecht School of human geography. In recent times Dutch academic geography has found her way back from the more applied modes of thought to more theoretically informed debates, to which she contributes substantially.

H. Ernste; L. Smith

2009-01-01T23:59:59.000Z

183

ORISE: Human Subjects Protection  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Subjects Protection Human Subjects Protection The Oak Ridge Institute for Science and Education (ORISE) performs technical assessments to assist U.S. Department of Energy (DOE) laboratories involved in human subjects research projects. Under DOE Order and Policy 443.1A, Protection of Human Subjects, and 10 CFR 745, DOE employees and contractors are expected to protect the rights and welfare of human research subjects. In support of the DOE Office of Science and the Human Subjects Protection Program (HSPP), ORISE has most recently assisted with the development and distribution of tools to address classified research and to track potential human social cultural behavior systems (HSCB) research conducted by DOE laboratories. Examples of products that ORISE has developed in support of the HSPP

184

An Integrated Physical and Gene Map of the 3.5-Mb Chromosome 3p21.3 (AP20) Region Implicated in Major Human Epithelial Malignancies  

Science Journals Connector (OSTI)

...construction of NotI jumping libraries in Ref. 16 ). This...36.3 kb of genomic space and was composed of...By screening of cDNA libraries and the Multiple Tissue...ESTs from heart cDNA library were available in public databases. The clone...

Alexei Protopopov; Vladimir Kashuba; Veronika I. Zabarovska; Olga V. Muravenko; Michael I. Lerman; George Klein; and Eugene R. Zabarovsky

2003-01-15T23:59:59.000Z

185

Abstract 3699: Multi-walled carbon nanotubes induce apoptosis in normal human small airway epithelial cells through proteasome-mediated Mcl-1 protein degradation  

Science Journals Connector (OSTI)

...Washington, DC Abstract 3699: Multi-walled carbon nanotubes induce...are emerging as the major building blocks in nanotechnology thanks...CNTs, including single- and multi-walled (SWCNTs and MWCNT...the anti-apoptotic Bcl-2 family proteins and found that only...

Bao-Zhu Yuan; Joshua Chapman; Yon Rojanasakul; Vincent Castranova; and Steven H. Reynolds

2011-01-10T23:59:59.000Z

186

The Adhesion AND Growth of Both the Human Primary Gingival Epithelial Cells and Streptococcus Mutans on Micro-Arc Oxidized Titanium  

Science Journals Connector (OSTI)

With good osseointegration properties, micro-arc oxidation has now gradually become the key point ... but interface between the implant surface treated by micro-arc oxidation and gingival soft tissues has been se...

Jiangning Lv; Hongwei Li; Ying Mu; ShuMin Wang

2014-11-01T23:59:59.000Z

187

Retinoic acid receptor- and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells  

Science Journals Connector (OSTI)

...H. B., M. F.], and SRI International, Menlo Park, California 94025...F.. H. B., M. FJ. and SRI International. Mento Park, Cali/arnia 94025...8-telramethyl-2-naphthamido)benzoic acid; SRI 1235. [2-15.6.7,8...

HY Lee; MI Dawson; GL Walsh; JC Nesbitt; RL Eckert; E Fuchs; WK Hong; R Lotan; and JM Kurie

1996-08-01T23:59:59.000Z

188

Tumor Necrosis Factor-? Increases Reactive Oxygen Species by Inducing Spermine Oxidase in Human Lung Epithelial Cells: A Potential Mechanism for Inflammation-Induced Carcinogenesis  

Science Journals Connector (OSTI)

...increasing levels of positive cell cycle regulators, as well as components...exposure to TNF-alpha, a general mediator of inflammation...molecular mechanism by which general inflammation can contribute...intratracheal administration of diesel exhaust particles. Carcinogenesis...

Naveen Babbar and Robert A. Casero, Jr.

2006-12-01T23:59:59.000Z

189

Epigenetic alterations mapped with human promoter tiling microarrays identify genes implicated in epithelial-mesenchymal transition in a breast cancer metastasis model.  

Science Journals Connector (OSTI)

...of gene expression might contribute directly to promotion of metastasis. Metastasis is a complex process involving sequential and interrelated steps. In this study, we have examined the impact of EWS/FLI expression on cell migration, cell...

David Rodenhiser; Joseph Andrews; Wendy Kennette; Bekim Sadikovic; Ariel Mendlowitz; Jenna Pilon; Alan Tuck; and Ann Chambers

2008-05-01T23:59:59.000Z

190

Detection of Human Lung Epithelial Cell Growth Factors Produced by a Lung Carcinoma Cell Line: Use in Culture of Primary Solid Lung Tumors  

Science Journals Connector (OSTI)

...PMSF, phenylmethylsulfonylfluoride; CFE, colony-forming efficiency. of cells...cells to A549-I CM. Fold increase in CFE over controls is shown for the response...responsedeterminedas percentageof control CFE. Fivewellswereusedper conditionand the...

Jill M. Siegfried

1987-06-01T23:59:59.000Z

191

Differences in pulmonary responses of rats, other animals, and humans to chronic inhalation of silica and other particles  

SciTech Connect

The pulmonary carcinogenicity of quartz in rats supports the plausibility of silica-induced lung cancer in humans. However, pulmonary responses of rats to dusts differ from those of other rodents, and may differ from those of humans. Dust-exposed rats have a greater propensity than mice or hamsters for epithelial hyperplasia, metaplasia, and fibrosis. Lung tumors occur in rats, but not mice or hamsters, treated with quartz, or exposed chronically to several other dusts. There are few opportunities for directly comparing the susceptibilities of rats and humans to dust-induced lung tumors. Because of the uncertain human responses to silica and many other particles, the negative human lung cancer response to coal dust may provide the best opportunity to calibrate responses of rats against those of humans. Historical dust lung burdens in coal miners were in the range of those associated with carcinogenicity in rats exposed to several dusts, but the carcinogenicity of coal dust in rats is unknown. The usefulness of tumor data from rats for predicting human lung cancer risk from inhaled silica and other dusts remains uncertain.

Mauderly, J.L.

1993-12-31T23:59:59.000Z

192

Contact List, Human Resources  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Resources & Occupational Medicine Division Human Resources & Occupational Medicine Division Contact List Human Resources Guest, User, Visitor (GUV) Center Occupational Medicine Training and Qualifications Office Note: All listed phone extensions are in the format of (631) 344-xxxx. Human Resources Robert Lincoln, Chief Human Resources Officer x7435 rlincoln@bnl.gov Margaret Hughes x2108 hughes@bnl.gov Elizabeth Gilbert x2315 gilbert@bnl.gov Human Resources Generalists Christel Colon, HR Manager - BES, GARS & ELS x8469 ccolon@bnl.gov Joann Williams, HR Manager - Support Operations x8356 williamsj@bnl.gov Joanna Hall, HR Manager - Photon Sciences x4410 jhall@bnl.gov Donna Dowling, HR Manager - Nuclear & Particle Physics x2754 dowling@bnl.gov Terrence Buck x8715 tbuck@bnl.gov

193

ORISE: Protecting Human Subjects  

NLE Websites -- All DOE Office Websites (Extended Search)

or performed by DOE employees, addresses the protection of human subjects. The Oak Ridge Institute for Science and Education (ORISE) supports DOE in its efforts to protect...

194

EMSL - human health  

NLE Websites -- All DOE Office Websites (Extended Search)

human-health en Physical Properties of Ambient and Laboratory-Generated Secondary Organic Aerosol. http:www.emsl.pnl.govemslwebpublicationsphysical-properties-ambient-and-labo...

195

TAK1 regulates NF-{Kappa}B and AP-1 activation in airway epithelial cells following RSV infection  

SciTech Connect

Respiratory syncytial virus (RSV) is the most common cause of epidemic respiratory diseases in infants and young children. RSV infection of airway epithelial cells induces the expression of immune/inflammatory genes through the activation of a subset of transcription factors, including Nuclear Factor-{kappa}B (NF-{kappa}B) and AP-1. In this study, we have investigated the signaling pathway leading to activation of these two transcription factors in response to RSV infection. Our results show that IKK{beta} plays a key role in viral-induced NF-{kappa}B activation, while JNK regulates AP-1-dependent gene transcription, as demonstrated by using kinase inactive proteins and chemical inhibitors of the two kinases. Inhibition of TAK1 activation, by overexpression of kinase inactive TAK1 or using cells lacking TAK1 expression, significantly reduced RSV-induced NF-{kappa}B and AP-1 nuclear translocation and DNA-binding activity, as well as NF-{kappa}B-dependent gene expression, identifying TAK1 as an important upstream signaling molecule regulating RSV-induced NF-{kappa}B and AP-1 activation. - Highlights: > IKK{beta} is a major kinase involved in RSV-induced NF-{kappa}B activation. > JNK regulates AP-1-dependent gene transcription in RSV infection. > TAK1 is a critical upstream signaling molecule for both pathways in infected cells.

Dey, Nilay; Liu Tianshuang [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Garofalo, Roberto P. [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX (United States); Department of Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX (United States); Casola, Antonella, E-mail: ancasola@utmb.edu [Department of Pediatrics, University of Texas Medical Branch, Galveston, TX (United States); Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX (United States); Department of Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX (United States)

2011-09-30T23:59:59.000Z

196

Science and Human Values  

Science Journals Connector (OSTI)

... THE three essays on "Science and Human A Values" which Dr. J. Bronowski has contributed to recent issues ... Dr. Bronowski discusses the sense of human dignity and challenges widely held views of what science is and does. These views are highly relevant to the current task of developing- ...

1957-02-02T23:59:59.000Z

197

integration division Human Systems  

E-Print Network (OSTI)

Vibration Test Facility incorporates state-of-the-art vibration generation and measurement hardwareintegration division Human Systems ISIS Vibration Test Facility Objective Approach Impact 1. Assess impact of flight-like whole-body vibration on human operational capabilities and ability to maintain

198

STUDENT EMPLOYMENT HUMAN RESOURCES  

E-Print Network (OSTI)

STUDENT EMPLOYMENT HUMAN RESOURCES GUIDELINE Human Resources | One Washington Square | San José, CA 95192-0046 | 408-924-2250 408-924-2284 (fax) SUBJECT: STUDENT EMPLOYMENT DATE: March 2007 I. PURPOSE / DESCRIPTION Student employees are defined as matriculated students that work part-time in any

Gleixner, Stacy

199

Human Functional Brain Imaging  

E-Print Network (OSTI)

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review Summary Brain Imaging #12 Dale ­ one of our first Trustees. Understanding the brain remains one of our key strategic aims today three-fold: · to identify the key landmarks and influences on the human functional brain imaging

Rambaut, Andrew

200

Protection of Human Subjects  

Directives, Delegations, and Requirements

The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects; and in DOE P 443.1A, Protection of Human Subjects, dated 12-20-07. Cancels DOE O 443.1. Canceled by DOE O 443.1B.

2007-12-20T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Protection of Human Subjects  

Directives, Delegations, and Requirements

To establish DOE procedures and responsibilities for implementing the policy and requirements set forth in 10 CFR Part 745, Protection of Human Subjects, ad in DOE P 443.1, Policy on the Protection of Human Subjects. Cancels DOE O 1300.3. Canceled by DOE O 443.1A.

2000-05-15T23:59:59.000Z

202

Thermodynamics and Humanism  

Science Journals Connector (OSTI)

... chapter, his intention appears to have been to write on the wider human aspects of thermodynamics, to contribute to scientific humanism, which he defines as the unification of the specialized ... body of the book is, however, a fairly straightforward explanation of the laws of thermodynamics, partly classical and partly statistical, which will undoubtedly be helpful to students of the ...

J. A. V. BUTLER

1947-07-19T23:59:59.000Z

203

Genomics of human longevity  

Science Journals Connector (OSTI)

...the original work is properly cited. Genomics of human longevity P. E. Slagboom 1...progress. human longevity|longevity genomics|epigenetics and ageing| 1. Introduction...Innovation Oriented Research Programme on Genomics (SenterNovem; IGE01014 and IGE5007...

2011-01-01T23:59:59.000Z

204

Humans and Gills  

NLE Websites -- All DOE Office Websites (Extended Search)

Humans and Gills Humans and Gills Name: Shelley Location: N/A Country: N/A Date: N/A Question: Is it true that some babies are born with some sort of gills? How and when do humans adapt from breathing inside to breathing outside of the womb? Replies: Whoa! You have received a great deal of false information. First, babies are not born with gills! Get that out of your thinking! Babies do not "breath" for oxygen in the womb. They do "practice breathing" using the amniotic fluid of the womb, but it is not doing them any good otherwise. All of the embryo and fetal needs are received through the placenta. The mother provides everything that is needed. As for the gills, there is a stage in the early human embryo development whereby humans do show gill slits, but not functional gills. Slits are not gills!! As a matter of fact, all vertebrates show these same gill slits.

205

Division of Human Resources Human Resources / Attendance and Leave Philosophy  

E-Print Network (OSTI)

Division of Human Resources PHILOSOPHY Human Resources / Attendance and Leave Philosophy Form Leave Act (FMLA). USF augments these provisions with local processes and philosophies and, in some cases

Meyers, Steven D.

206

Special Issue on Human Computing  

E-Print Network (OSTI)

The seven articles in this special issue focus on human computing. Most focus on two challenging issues in human computing, namely, machine analysis of human behavior in group interactions and context-sensitive modeling.

Nijholt, Anton

207

The human genome project  

SciTech Connect

The Human Genome Project will obtain high-resolution genetic and physical maps of each human chromosome and, somewhat later, of the complete nucleotide sequence of the deoxyribonucleic acid (DNA) in a human cell. The talk will begin with an extended introduction to explain the Project to nonbiologists and to show that map construction and sequence determination require extensive computation in order to determine the correct order of the mapped entities and to provide estimates of uncertainty. Computational analysis of the sequence data will become an increasingly important part of the project, and some computational challenges are described. 5 refs.

Bell, G.I.

1991-06-01T23:59:59.000Z

208

miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohns disease  

SciTech Connect

Highlights: NOD2 is a target gene of miR-122. miR-122 inhibits LPS-induced apoptosis by suppressing NOD2 in HT-29 cells. miR-122 reduces the expression of pro-inflammatory cytokines (TNF-? and IFN-?). miR-122 promotes the release of anti-inflammatory cytokines (IL-4 and IL-10). NF-?B signaling pathway is involved in inflammatory response induced by LPS. -- Abstract: Crohns disease (CD) is one of the two major types of inflammatory bowel disease (IBD) thought to be caused by genetic and environmental factors. Recently, miR-122 was found to be deregulated in association with CD progression. However, the underlying molecular mechanisms remain unclear. In the present study, the gene nucleotide-binding oligomerization domain 2 (NOD2/CARD15), which is strongly associated with susceptibility to CD, was identified as a functional target of miR-122. MiR-122 inhibited LPS-induced apoptosis by suppressing NOD2 in HT-29 cells. NOD2 interaction with LPS initiates signal transduction mechanisms resulting in the activation of nuclear factor ?B (NF-?B) and the stimulation of downstream pro-inflammatory events. The activation of NF-?B was inhibited in LPS-stimulated HT-29 cells pretreated with miR-122 precursor or NOD2 shRNA. The expression of the pro-inflammatory cytokines TNF-? and IFN-? was significantly decreased, whereas therelease of the anti-inflammatory cytokines IL-4 and IL-10 was increased in LPS-stimulated HT-29 cells pretreated with miR-122 precursor, NOD2 shRNA or the NF-?B inhibitor QNZ. Taken together, these results indicate that miR-122 and its target gene NOD2 may play an important role in the injury of intestinal epithelial cells induced by LPS.

Chen, Yu; Wang, Chengxiao; Liu, Ying; Tang, Liwei; Zheng, Mingxia [Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434 (China)] [Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434 (China); Xu, Chundi [Department of Pediatrics, Ruijin affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025 (China)] [Department of Pediatrics, Ruijin affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025 (China); Song, Jian, E-mail: jiansongkxy@126.com [Department of Gastroenterology, Jiangwan Hospital of Shanghai, Shanghai 200434 (China)] [Department of Gastroenterology, Jiangwan Hospital of Shanghai, Shanghai 200434 (China); Meng, Xiaochun [Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434 (China)] [Department of Pediatrics, Jiangwan Hospital of Shanghai, Shanghai 200434 (China)

2013-08-16T23:59:59.000Z

209

Spontaneous Human Combustion  

NLE Websites -- All DOE Office Websites (Extended Search)

Spontaneous Human Combustion Spontaneous Human Combustion Name: S. Phillips. Age: N/A Location: N/A Country: N/A Date: N/A Question: One of our 8th grade students has tried to find information in our library about spontaneous human combustion, but to no avail. Could you tell us where we might locate a simple reference, or provide some in information about this subject for him. Replies: Sorry, but this is definitely "fringe science"...try asking in bookstores. I seem to recall one of those "believe it or not" type of TV shows did an episode on spontaneous human combustion a few years ago in which they reported on some British scientists who investigated this purported phenomenon. Remember that people (back in the Dark Ages, and before) used to believe in "spontaneous generation" of certain plants and animals because they were not aware of the reproduction methods used by those plants and animals.

210

TEMPORARY SUPPORT HUMAN RESOURCES  

E-Print Network (OSTI)

TEMPORARY SUPPORT HUMAN RESOURCES GUIDELINE Workforce Planning | One Washington Square | San José of the Request for Temporary Support, Workforce Planning will make a determination of the type of temporary

Su, Xiao

211

Human intelligible positioning  

E-Print Network (OSTI)

We use street addresses to refer to locations in a city. Street addresses are easy to remember and communicate because they follow a symbolic addressing scheme, containing human intelligible symbols. However, street addresses ...

Venugopalan, Vishwanath, 1981-

2004-01-01T23:59:59.000Z

212

KRFTWRK Global Human Electricity  

E-Print Network (OSTI)

Power Network 2.1.1 Virtual Power Plants The Global Powernetwork, based on "Virtual Power Plants", called "VPP". A "participant runs a virtual human power plant. Per every "

Prohaska, Rainer

2009-01-01T23:59:59.000Z

213

Human Reliability Program Overview  

SciTech Connect

This presentation covers the high points of the Human Reliability Program, including certification/decertification, critical positions, due process, organizational structure, program components, personnel security, an overview of the US DOE reliability program, retirees and academia, and security program integration.

Bodin, Michael

2012-09-25T23:59:59.000Z

214

Humans Need Biodiversity  

Science Journals Connector (OSTI)

...economic, and environmental policiesthe three pillars of sustainability practiceto manage natural resource...bright light on the tight connections between sustainability practices and human survival could make conservation...

David P. Mindell

2009-03-20T23:59:59.000Z

215

Human Resource Management Delegation  

Directives, Delegations, and Requirements

The notice is to clarifies and updates existing Human Resource Management Delegation Authorities and the levels to which they are delegated. Expired 6-28-97. Does not cancel any directives.

1996-06-28T23:59:59.000Z

216

Human Resources & Rebecca Leinen  

E-Print Network (OSTI)

Human Resources & Training Rebecca Leinen SafetyInformation Systems Chris Smeds Work Management Mark Webb Energy & Utilities Cheryl Gomez Operations & Maintenance Cheryl Gomez, interim Systems Services Delta Force Recycling Sustainability Outreach Office for Sustainability Utility Systems Power

Acton, Scott

217

Protection of Human Subjects  

Directives, Delegations, and Requirements

The purpose of this Policy is to establish DOE-specific policy for the protection of human subjects involved in DOE research. Canceled by DOE P 443.1A.

2000-05-15T23:59:59.000Z

218

Protection of Human Subjects  

Directives, Delegations, and Requirements

The Policy is to establish DOE-specific principles for the protection of human subjects involved in DOE research. Cancels DOE P 443.1. Canceled by DOE O 443.1B

2007-12-20T23:59:59.000Z

219

Human Factors Review Plan  

SciTech Connect

''Human Factors'' is concerned with the incorporation of human user considerations into a system in order to maximize human reliability and reduce errors. This Review Plan is intended to assist in the assessment of human factors conditions in existing DOE facilities. In addition to specifying assessment methodologies, the plan describes techniques for improving conditions which are found to not adequately support reliable human performance. The following topics are addressed: (1) selection of areas for review describes techniques for needs assessment to assist in selecting and prioritizing areas for review; (2) human factors engineering review is concerned with optimizing the interfaces between people and equipment and people and their work environment; (3) procedures review evaluates completeness and accuracy of procedures, as well as their usability and management; (4) organizational interface review is concerned with communication and coordination between all levels of an organization; and (5) training review evaluates training program criteria such as those involving: trainee selection, qualification of training staff, content and conduct of training, requalification training, and program management.

Paramore, B.; Peterson, L.R. (eds.)

1985-12-01T23:59:59.000Z

220

The Human Genome From human genome to other  

E-Print Network (OSTI)

genome to health Structural Genomics initiative #12;What is the Human Genome Project? · U.S. govtThe Human Genome Project From human genome to other genomes and to gene function June 2000 From that arise from genome research #12;The Human Genome Project Project began in 1990 as a $3 billion, 15-year

Linial, Michal

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Time, Humans and Societal Challenges  

E-Print Network (OSTI)

,000 (human development) Since 1850 (industrial revolution Since 1950 (population explosion) Sustainable

222

Human hybrid hybridoma  

SciTech Connect

Hybrid hybridomas are obtained by fusion of two cells, each producing its own antibody. Several authors have reported the construction of murine hybrid hybridomas with the aim to obtain bispecific monoclonal antibodies. The authors have investigated, in a model system, the feasibility of constructing a human hybrid hybridoma. They fused two monoclonal cell lines: an ouabain-sensitive and azaserine/hypoxanthine-resistant Epstein-Barr virus-transformed human cell line that produces an IgG1kappa antibody directed against tetanus toxiod and an azaserine/hypoxanthine-sensitive and ouabain-resistant human-mouse xenohybrid cell line that produces a human IgG1lambda antibody directed against hepatitis-B surface antigen. Hybrid hybridoma cells were selected in culture medium containing azaserine/hypoxanthine and ouabain. The hybrid nature of the secreted antibodies was analyzed by means of two antigen-specific immunoassay. The results show that it is possible, with the combined use of transformation and xenohybridization techniques, to construct human hybrid hybridomas that produce bispecific antibodies. Bispecific antibodies activity was measured by means of two radioimmunoassays.

Tiebout, R.F.; van Boxtel-Oosterhof, F.; Stricker, E.A.M.; Zeijlemaker, W.P.

1987-11-15T23:59:59.000Z

223

Relocation Guide, Human Resources  

NLE Websites -- All DOE Office Websites (Extended Search)

Relocation Information Guide Relocation Information Guide The Human Resources Division is providing this Information Guide to you to help ease the transition of relocating to Long Island. Relocating to a new place can be an exciting as well as stressful time. We have compiled information that can be very helpful with the many issues you may face. You may also seek assistance from the recruiter you work with in Human Resources. Service Disclaimer - This web page contains links to other Internet sites. These links are not endorsements of any products or services and no information in such site has been endorsed or approved by Brookhaven National Laboratory or the Human Resources Division. Here are some of the issues: Cost of living Buying or renting a home Schools in the area

224

Turkey vs. human digestion  

NLE Websites -- All DOE Office Websites (Extended Search)

Turkey vs. human digestion Turkey vs. human digestion Name: wallyb Location: N/A Country: N/A Date: N/A Question: How is the digestive system of turkeys different from that of humans? Replies: Hmmm.. been a while since I had sophomore biology, so I can't completely answer this one, but I can say a few things. One, since turkeys are birds, and birds as a general rule have not had teeth for several million years at least, the turkey needs a way to mash up its food -- thus, the crop, which is essentially like another stomach: the turkey (and many other birds, for that matter) swallows small stones which serve in lieu of teeth, mashing up food via muscular action in the crop, from whence the "chewed" food moves on into the rest of the digestive tract. As for any other differences, I'll have to leave that to someone else with more ornithological experience...

225

Human MSH2 protein  

DOE Patents (OSTI)

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

de la Chapelle, Albert (Helsingfors, FI); Vogelstein, Bert (Baltimore, MD); Kinzler, Kenneth W. (Baltimore, MD)

1997-01-01T23:59:59.000Z

226

Human MSH2 protein  

DOE Patents (OSTI)

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.

Chapelle, A. de la; Vogelstein, B.; Kinzler, K.W.

1997-01-07T23:59:59.000Z

227

A Novel Function of YWHAZ/?-Catenin Axis in Promoting EpithelialMesenchymal Transition and Lung Cancer Metastasis  

Science Journals Connector (OSTI)

...Erickson P, Bemis L, Li E, et alAltered HOX and WNT7A expression in human lung cancer.Proc Natl Acad Sci U S A 2000;97:12776-81. 40. Kase S , Sugio K, Yamazaki K, Okamoto T, Yano T, Sugimachi K.Expression of E-cadherin and beta-catenin...

Ching-Hsien Chen; Show-Mei Chuang; Meng-Fang Yang; Jiunn-Wang Liao; Sung-Liang Yu; Jeremy J.W. Chen

2012-10-01T23:59:59.000Z

228

Epithelial-Mesenchymal Interactions  

Science Journals Connector (OSTI)

...eliminate labor and cleaning equipment costs * Let you use new cage for each experiment...Lexington Ave., New York 10017) 4-6. Nuclear Mletallutrgy Conf.. Phoenix. Ariz...Ave.. Chicago. 111. 60611) 30-2. Nuclear Science. 14th symp., Los Angeles...

Raul Fleischmajer

1967-09-22T23:59:59.000Z

229

Human Rights and Duties  

Science Journals Connector (OSTI)

... European convention. A draft European convention for the collective protection of individual rights and democratic liberties by member States of the Council of Europe, and for the establishment of a ... accompanied by a recommendation that the whole question of the maintenance of human rights and liberties should be placed upon the agenda of the first session of the European Consultative Assembly ...

1950-01-21T23:59:59.000Z

230

Ubiquitous human computing  

Science Journals Connector (OSTI)

...tomorrow's human one. The Internet faced down proprietary networks...organically the way that the Internet's byways are not owned in...that is in the way the current Internet and its protocols are unowned...significantly different vectors of abuse and control than the one run...

2008-01-01T23:59:59.000Z

231

Ethics, humanity, and science  

Science Journals Connector (OSTI)

Ethics, humanity, and science ... In this issue of the magazine C&EN senior editor Wil Lepkowski, in effect, picks up on this theme with an examination of a debate that may be about to erupt over the methods and ethics of science and scientists, particularly as they apply to the central role of science and technology in the nuclear arms race. ...

MICHEAL HEYLIN

1981-10-05T23:59:59.000Z

232

THE SCIENCE OF HUMANITY  

Science Journals Connector (OSTI)

...one as silver and the other as gold, and have done doughty battle in defense of their one-sided vision; the biol-ogist...peoples, or of human curiosities and monstrosities exhibited in midway plaisances, if nlot in circuses and dime mu-seums. Even...

W J MCGEE

1897-09-17T23:59:59.000Z

233

E-Print Network 3.0 - acid inhibits tumor Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

we show here that intrametastatic lymphatic vessels and bulk tumor cell... model of tumor bulk invasion, human mammary carcinoma cells caused ... Source: Floreano, Dario -...

234

Human sciences The human sciences database contains approximately 254 academic  

E-Print Network (OSTI)

Human sciences The human sciences database contains approximately 254 academic journals and statistical reports on the following subjects: (comparative literature, theology, history and geography, education, psychology, arts, languages and Library Science) Social sciences The social sciences database

235

Human-elephant conflicts; Human-elephant conflicts.  

E-Print Network (OSTI)

?? It is widely recognized that human-wildlife conflicts can reduce farmers support for long-term species conservation. The subject of human-elephant conflicts is highly relevant in (more)

Olsson, Linnea

2014-01-01T23:59:59.000Z

236

Effects of the PPAR{gamma} agonist troglitazone on endothelial cells in vivo and in vitro: Differences between human and mouse  

SciTech Connect

Peroxisome proliferator-activated receptor gamma (PPAR{gamma}) agonists and PPAR{gamma}/{alpha} dual agonists have been or are being developed for clinical use in the treatment of type 2 diabetes mellitus and hyperlipidemias. A common tumor finding in rodent carcinogenicity studies for these agonists is hemangioma/hemangiosarcoma in mice but not in rats. We hypothesized that increased endothelial cell proliferation may be involved in the mechanism of PPAR agonist-induced vascular tumors in mice, and we investigated the effects on endothelial cells utilizing troglitazone, the first clinically used PPAR{gamma} agonist, in vivo and in vitro. Troglitazone (400 and 800 mg/kg/day) induced hemangiosarcomas in mice in a 2-year bioassay. We showed that troglitazone increased endothelial cell proliferation in brown and white adipose tissue and liver in mice at sarcomagenic doses after 4 weeks of treatment. Troglitazone was cytotoxic both to human dermal microvascular endothelial cells (HMEC1) and mouse mammary fat pad microvascular endothelial cells (MFP MVEC) at high concentrations. However, MFP MVEC were more resistant to the cytotoxic effects of troglitazone based on the much lower LC{sub 50} in HMEC1 (17.4 {mu}M) compared to MFP MVEC (92.2 {mu}M). Troglitazone increased the proliferation and survival of MFP MVEC but not HMEC1 in growth factor reduced conditions. Our data demonstrate that troglitazone may induce hemangiosarcomas in mice, at least in part, through enhancement of survival and proliferation of microvascular endothelial cells. Such an effect does not occur with human cells, suggesting that human may react differently to exposure to PPAR agonists compared with mice.

Kakiuchi-Kiyota, Satoko [Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135 (United States); Vetro, Joseph A. [Center for Drug Delivery and Nanomedicine and Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025 (United States); Suzuki, Shugo; Varney, Michelle L. [Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135 (United States); Han, Huai-Yun [Center for Drug Delivery and Nanomedicine and Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198-6025 (United States); Nascimento, Merielen; Pennington, Karen L.; Arnold, Lora L.; Singh, Rakesh K. [Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135 (United States); Cohen, Samuel M. [Department of Pathology and Microbiology and the Eppley Institute for Cancer Research, University of Nebraska Medical Center, 983135 Nebraska Medical Center Omaha, NE 68198-3135 (United States)], E-mail: scohen@unmc.edu

2009-05-15T23:59:59.000Z

237

Antioxidant and Anti-Inflamatory Effects and Mechanisms of Green Tea in Vitro in Vascular Epithelial Cells  

E-Print Network (OSTI)

or lone electrons. These electrons are reactive and have the capability to cause damage to tissues if left in their unstable state. In order to counteract these free radicals there are antioxidants which seek out the free radicals and bind to them... Cells. (April 2009) Abida Hasan Department of Nutritional Sciences Texas A&M University Research Advisor: Dr. Susanne Talcott Department of Nutritional Sciences In the human body there are free radicals present which have one or many unpaired...

Hasan, Abida

2011-08-04T23:59:59.000Z

238

Research Using Human Subjects/Materials  

NLE Websites -- All DOE Office Websites (Extended Search)

Research Using Human SubjectsMaterials (taken in part from "Research on Human Specimens", National Institutes of Health) A 'human subject' is a living individual about whom an...

239

PIA - Human Resources Information System (HRIS) | Department...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Information System (HRIS) PIA - Human Resources Information System (HRIS) PIA - Human Resources Information System (HRIS) PIA - Human Resources Information System (HRIS) More...

240

PIA - Human Resources Management Information System (HRMIS) ...  

Energy Savers (EERE)

Information System (HRMIS) PIA - Human Resources Management Information System (HRMIS) PIA - Human Resources Management Information System (HRMIS) PIA - Human Resources Management...

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Radiation effects on humans  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation effects on humans Radiation effects on humans Name: Joe Kemna Location: N/A Country: N/A Date: N/A Question: I am trying to find information on radiation. I need the effects on humans, the damage it causes to the environment, and any extra information you might have on the subject. Thank you for your time. Replies: Your library should be a good place to start, but first you need to narrow your question a bit. "Radiation" means radio waves, heat, light (including the ultraviolet light that causes suntan and sunburn), and what's called "ionizing radiation." By far the major source of the first three is the Sun, while the last I believe comes principally from cosmic rays and various naturally radioactive elements like uranium and radon. The most significant manmade sources of exposure would --- I think --- be household wiring and appliances (radio), engines and heating devices (heat), lamps (light), and X-ray machines, flying at high altitude in airplanes, and living in well-insulated homes built over radon sources (ionizing radiation). Heat, light and ionizing radiation play vital roles in the ecology of the Earth. Radio, light (in particular "tanning" ultraviolet), and ionizing radiation have all been widely assumed at different times to be particularly good or particularly bad for human health. Some recent issues of public concern have been the effect of radio waves from electric transmission lines, the effect on skin cancer incidence from tanning and sunburns, the depletion of the ultraviolet-light-produced ozone in the upper atmosphere by chlorofluorocarbons (CFCs), "global warming" from the increased absorption of heat radiation from the surface by atmospheric carbon dioxide and methane, and the effect of a long exposure to low levels of ionizing radiation as for example the people of Eastern Europe are experiencing from the Chernobyl nuclear power plant accident.

242

Human Genetics Portfolio Review Summary  

E-Print Network (OSTI)

the past 20 years, from our contribution to the Human Genome Project at the Sanger Institute to our role during this time. The drive to maximise the health benefits of human genome research remains a core to build research capacity and infrastructure to support human genetics and genomics · providing generous

Rambaut, Andrew

243

Human Capital Management Accountability Program  

Directives, Delegations, and Requirements

The Order establishes requirements, roles and responsibilities for the Human Capital Management Accountability Program (HCMAP) for human resources programs and personnel and ensures that human capital activities are regulatory and procedurally compliant with Federal statutes and Departmental policies. Does not cancel other directives.

2008-08-01T23:59:59.000Z

244

Eye Color in Humans  

NLE Websites -- All DOE Office Websites (Extended Search)

Eye Color in Humans Eye Color in Humans Name: Kristi Location: N/A Country: N/A Date: N/A Question: The dominant characteristic is the one most likely to appear in the offspring. In human beings, brown is the dominant color for eyes. The children who inherit at least on dominant gene will have either brown, green, or hazel eyes. Only childten who inherit two recessive genes will have pure blue eyes. If there are eight children in the family, what color eyes will most of them have? Replies: http://www.newton.dep.anl.gov/archive.htm Search under eye color Steve Sample You answer is of course dependent on the genes of the parents. If both parents do not have the recessive gene, then no children will have light colored eyes. If one has a recessive gene and the other not, then still no children will have light color eyes and on the average 25% of the eight children could have the recessive gene. If both parents have the recessive gene, then 25% of the eight children could have light color eyes.

245

Dog vs. human language  

NLE Websites -- All DOE Office Websites (Extended Search)

Dog vs. human language Dog vs. human language Name: Michelle Conte Location: N/A Country: N/A Date: N/A Question: Why can't dogs talk like humans? Replies: In very simple terms, they aren't made for it. In order to produce any kind of vocal sound, we not only need a set of vocal chords (or vibratory organs of some sort), we also need an air pipe and cranium shaped to deliver the vibrations in the right way -- you actually use your own head as a sort of sounding plate for several primary sounds (non-percussive) Dogs don't have the right shaped heads for the job, as well as the inability to vocalize many of the percussive sounds which make up a good percentage of our languages due to a differently shaped mouth. However, all things considered, we'd be ill-equipped to call meetings over long distances by simply howling, like dogs and their kin are wont to do in the wild.

246

Abstract #174: Human Ductal Carcinoma In Situ contains malignant progenitor cells  

Science Journals Connector (OSTI)

...BRCA1 promoter hypermethylation does not hold promise for risk-stratifying...22 Jones PA, Baylin SB. The fundamental role of epigenetic events in...cancer-associated gene 1 promoter does not predict cytologic atypia...mathematical risk models and (b) does not predict mammary atypia in...

Virginia Espina; Lucia Pastore; Luana Adamo; Mariaelena Pierobon; Stacey Banks; Barbara Merritt; Jasbir Johal; Syed Zaman; Emanuel Petricoin; Kirsten Edmiston; and Lance Liotta

2009-05-01T23:59:59.000Z

247

Aspects of nitrogen dioxide toxicity in environmental urban concentrations in human nasal epithelium  

SciTech Connect

Cytotoxicity and genotoxicity of nitrogen dioxide (NO{sub 2}) as part of urban exhaust pollution are widely discussed as potential hazards to human health. This study focuses on toxic effects of NO{sub 2} in realistic environmental concentrations with respect to the current limit values in a human target tissue of volatile xenobiotics, the epithelium of the upper aerodigestive tract. Nasal epithelial cells of 10 patients were cultured as an air-liquid interface and exposed to 0.01 ppm NO{sub 2}, 0.1 ppm NO{sub 2}, 1 ppm NO{sub 2}, 10 ppm NO{sub 2} and synthetic air for half an hour. After exposure, genotoxicity was evaluated by the alkaline single-cell microgel electophoresis (Comet) assay and by induction of micronuclei in the micronucleus test. Depression of proliferation and cytotoxic effects were determined using the micronucleus assay and trypan blue exclusion assay, respectively. The experiments revealed genotoxic effects by DNA fragmentation starting at 0.01 ppm NO{sub 2} in the Comet assay, but no micronucleus inductions, no changes in proliferation, no signs of necrosis or apoptosis in the micronucleus assay, nor did the trypan blue exclusion assay show any changes in viability. The present data reveal a possible genotoxicity of NO{sub 2} in urban concentrations in a screening test. However, permanent DNA damage as indicated by the induction of micronuclei was not observed. Further research should elucidate the effects of prolonged exposure.

Koehler, C.; Ginzkey, C.; Friehs, G.; Hackenberg, S.; Froelich, K.; Scherzed, A.; Burghartz, M.; Kessler, M. [Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg (Germany); Kleinsasser, N., E-mail: Kleinsasser_N@klinik.uni-wuerzburg.d [Department of Oto-Rhino-Laryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University of Wuerzburg (Germany)

2010-06-01T23:59:59.000Z

248

A Gene Map of the Human Genome  

Science Journals Connector (OSTI)

...sanger.ac.uk/ Stanford Human Genome Center http://www-shgc.stanford.edu/ Wellcome Trust Centre for Human...sanger.ac.ukl Stanford Human Genome Center http://www-shgc.stanford.edu/ Wellcome Trust Centre for Human Genetics http...

G. D. Schuler; M. S. Boguski; E. A. Stewart; L. D. Stein; G. Gyapay; K. Rice; R. E. White; P. Rodriguez-Tom; A. Aggarwal; E. Bajorek; S. Bentolila; B. B. Birren; A. Butler; A. B. Castle; N. Chiannilkulchai; A. Chu; C. Clee; S. Cowles; P. J. R. Day; T. Dibling; N. Drouot; I. Dunham; S. Duprat; C. East; C. Edwards; J.-B. Fan; N. Fang; C. Fizames; C. Garrett; L. Green; D. Hadley; M. Harris; P. Harrison; S. Brady; A. Hicks; E. Holloway; L. Hui; S. Hussain; C. Louis-Dit-Sully; J. Ma; A. MacGilvery; C. Mader; A. Maratukulam; T. C. Matise; K. B. McKusick; J. Morissette; A. Mungall; D. Muselet; H. C. Nusbaum; D. C. Page; A. Peck; S. Perkins; M. Piercy; F. Qin; J. Quackenbush; S. Ranby; T. Reif; S. Rozen; C. Sanders; X. She; J. Silva; D. K. Slonim; C. Soderlund; W.-L. Sun; P. Tabar; T. Thangarajah; N. Vega-Czarny; D. Vollrath; S. Voyticky; T. Wilmer; X. Wu; M. D. Adams; C. Auffray; N. A. R. Walter; R. Brandon; A. Dehejia; P. N. Goodfellow; R. Houlgatte; J. R. Hudson Jr.; S. E. Ide; K. R. Iorio; W. Y. Lee; N. Seki; T. Nagase; K. Ishikawa; N. Nomura; C. Phillips; M. H. Polymeropoulos; M. Sandusky; K. Schmitt; R. Berry; K. Swanson; R. Torres; J. C. Venter; J. M. Sikela; J. S. Beckmann; J. Weissenbach; R. M. Myers; D. R. Cox; M. R. James; D. Bentley; P. Deloukas; E. S. Lander; T. J. Hudson

1996-10-25T23:59:59.000Z

249

Mentoring Human Performance - 12480  

SciTech Connect

Although the positive effects of implementing a human performance approach to operations can be hard to quantify, many organizations and industry areas are finding tangible benefits to such a program. Recently, a unique mentoring program was established and implemented focusing on improving the performance of managers, supervisors, and work crews, using the principles of Human Performance Improvement (HPI). The goal of this mentoring was to affect behaviors and habits that reliably implement the principles of HPI to ensure continuous improvement in implementation of an Integrated Safety Management System (ISMS) within a Conduct of Operations framework. Mentors engaged with personnel in a one-on-one, or one-on-many dialogue, which focused on what behaviors were observed, what factors underlie the behaviors, and what changes in behavior could prevent errors or events, and improve performance. A senior management sponsor was essential to gain broad management support. A clear charter and management plan describing the goals, objectives, methodology, and expected outcomes was established. Mentors were carefully selected with senior management endorsement. Mentors were assigned to projects and work teams based on the following three criteria: 1) knowledge of the work scope; 2) experience in similar project areas; and 3) perceived level of trust they would have with project management, supervision, and work teams. This program was restructured significantly when the American Reinvestment and Recovery Act (ARRA) and the associated funding came to an end. The program was restructured based on an understanding of the observations, attributed successes and identified shortfalls, and the consolidation of those lessons. Mentoring the application of proven methods for improving human performance was shown effective at increasing success in day-to-day activities and increasing confidence and level of skill of supervisors. While mentoring program effectiveness is difficult to measure, and return on investment is difficult to quantify, especially in complex and large organizations where the ability to directly correlate causal factors can be challenging, the evidence presented by Sydney Dekker, James Reason, and others who study the field of human factors does assert managing and reducing error is possible. Employment of key behaviors-HPI techniques and skills-can be shown to have a significant impact on error rates. Our mentoring program demonstrated reduced error rates and corresponding improvements in safety and production. Improved behaviors are the result, of providing a culture with consistent, clear expectations from leadership, and processes and methods applied consistently to error prevention. Mentoring, as envisioned and executed in this program, was effective in helping shift organizational culture and effectively improving safety and production. (authors)

Geis, John A.; Haugen, Christian N. [CALIBRE Systems, Inc., Alexandria, Virginia (United States)

2012-07-01T23:59:59.000Z

250

Human Genome Program  

SciTech Connect

The DOE Human Genome program has grown tremendously, as shown by the marked increase in the number of genome-funded projects since the last workshop held in 1991. The abstracts in this book describe the genome research of DOE-funded grantees and contractors and invited guests, and all projects are represented at the workshop by posters. The 3-day meeting includes plenary sessions on ethical, legal, and social issues pertaining to the availability of genetic data; sequencing techniques, informatics support; and chromosome and cDNA mapping and sequencing.

Not Available

1993-01-01T23:59:59.000Z

251

Origins and consequences of radiation…induced centrosome aberrations  

NLE Websites -- All DOE Office Websites (Extended Search)

Origins and consequences of radiation-induced centrosome aberrations Origins and consequences of radiation-induced centrosome aberrations Sangeetha Vijayakumar, Nisarg Shah, Ignacio Fernandez-Garcia, Mary Helen Barcellos-Hoff Department of Radiation Oncology, New York University School of Medicine, NY, NY. Centrosome aberrations are frequently observed in pre-neoplastic breast lesions and are known to drive chromosomal instability (Lingle et al., 2002). Previous studies from our lab have shown that human mammary epithelial cells exposed to low doses of radiation exhibit centrosome aberrations (CAs) in a dose dependent manner from 10-200 cGy (Maxwell et al., 2008). These data demonstrated that radiation-induced CAs actually precede and generate genomic instability and that TGFβ is a key mediator

252

Origins and consequences of radiation–induced centrosome aberrations  

NLE Websites -- All DOE Office Websites (Extended Search)

Origins and consequences of radiation–induced centrosome aberrations Origins and consequences of radiation–induced centrosome aberrations Sangeetha Vijayakumar New York University School of Medicine Abstract Centrosome aberrations are frequently observed in pre-neoplastic breast lesions and are known to drive chromosomal instability (Lingle et al., 2002). Previous studies from our lab have shown that human mammary epithelial cells exposed to low doses of radiation exhibit centrosome aberrations (CAs) in a dose dependent manner from 10-200 cGy (Maxwell et al., 2008). These data demonstrated that radiation-induced CAs actually precede and generate genomic instability and that TGFβ is a key mediator of genomic surveillance by eliminating genomically unstable cells through p53-dependent apoptosis. While high dose radiation has been shown to cause centrosome aberrations

253

Report: EM Human Capital Initiatives  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

HUMAN CAPITAL HUMAN CAPITAL September 25, 2008 Submitted by the EMAB Human Capital Subcommittee Background: The enhancement of the Office of Environmental Management's (EM) human capital has been a central tenet of the Assistant Secretary's tenure, reflecting the critical nature of this resource to the achievement of EM's mission. Beginning in Fiscal Year (FY) 2006, the Environmental Management Advisory Board (EMAB or Board) has reviewed the program's human capital issues and the plans EM has developed to address them. This review produced a number of recommendations that were presented in the Board's FY 2006 report to the Assistant Secretary and were later approved and implemented to varying degrees. * Recommendation 2006-01: Develop accountability for the Human Capital Plan

254

Human Reliability Program Workshop  

SciTech Connect

A Human Reliability Program (HRP) is designed to protect national security as well as worker and public safety by continuously evaluating the reliability of those who have access to sensitive materials, facilities, and programs. Some elements of a site HRP include systematic (1) supervisory reviews, (2) medical and psychological assessments, (3) management evaluations, (4) personnel security reviews, and (4) training of HRP staff and critical positions. Over the years of implementing an HRP, the Department of Energy (DOE) has faced various challenges and overcome obstacles. During this 4-day activity, participants will examine programs that mitigate threats to nuclear security and the insider threat to include HRP, Nuclear Security Culture (NSC) Enhancement, and Employee Assistance Programs. The focus will be to develop an understanding of the need for a systematic HRP and to discuss challenges and best practices associated with mitigating the insider threat.

Landers, John; Rogers, Erin; Gerke, Gretchen

2014-05-18T23:59:59.000Z

255

Annotating individual human genomes  

Science Journals Connector (OSTI)

Advances in DNA sequencing technologies have made it possible to rapidly, accurately and affordably sequence entire individual human genomes. As impressive as this ability seems, however, it will not likely amount to much if one cannot extract meaningful information from individual sequence data. Annotating variations within individual genomes and providing information about their biological or phenotypic impact will thus be crucially important in moving individual sequencing projects forward, especially in the context of the clinical use of sequence information. In this paper we consider the various ways in which one might annotate individual sequence variations and point out limitations in the available methods for doing so. It is arguable that, in the foreseeable future, DNA sequencing of individual genomes will become routine for clinical, research, forensic, and personal purposes. We therefore also consider directions and areas for further research in annotating genomic variants.

Ali Torkamani; Ashley A. Scott-Van Zeeland; Eric J. Topol; Nicholas J. Schork

2011-01-01T23:59:59.000Z

256

Simulating human behavior for national security human interactions.  

SciTech Connect

This 3-year research and development effort focused on what we believe is a significant technical gap in existing modeling and simulation capabilities: the representation of plausible human cognition and behaviors within a dynamic, simulated environment. Specifically, the intent of the ''Simulating Human Behavior for National Security Human Interactions'' project was to demonstrate initial simulated human modeling capability that realistically represents intra- and inter-group interaction behaviors between simulated humans and human-controlled avatars as they respond to their environment. Significant process was made towards simulating human behaviors through the development of a framework that produces realistic characteristics and movement. The simulated humans were created from models designed to be psychologically plausible by being based on robust psychological research and theory. Progress was also made towards enhancing Sandia National Laboratories existing cognitive models to support culturally plausible behaviors that are important in representing group interactions. These models were implemented in the modular, interoperable, and commercially supported Umbra{reg_sign} simulation framework.

Bernard, Michael Lewis; Hart, Dereck H.; Verzi, Stephen J.; Glickman, Matthew R.; Wolfenbarger, Paul R.; Xavier, Patrick Gordon

2007-01-01T23:59:59.000Z

257

RECRUITMENT SEARCH FIRMS HUMAN RESOURCES  

E-Print Network (OSTI)

RECRUITMENT SEARCH FIRMS HUMAN RESOURCES GUIDELINES Workforce Planning | Washington Square, San by the Workforce Planning Unit in Human Resources at SJSU. Process Consistent, defensible processes for evaluating of the recruitment. - At this meeting, the Workforce Planning analyst can provide contact information for search

Su, Xiao

258

Human viruses: discovery and emergence  

Science Journals Connector (OSTI)

...whether or not it poses a risk to humans, would be...will pose a serious risk to public health but...situation will require both political will and considerable investment in infrastructure...Woolhouse, M. E. J. 2001 Risk factors for human disease...

2012-01-01T23:59:59.000Z

259

The human activity of visualization  

E-Print Network (OSTI)

Griffin et al 2006 #12;Human-Computer Interaction: Software of the Mind each user has a setThe human activity of visualization cultural and psychological factors in representation; Gibbon 1998; Marcus 2000) conventions and metaphors of Westerners may not hold worldwide colors

Wright, Dawn Jeannine

260

Human Genome Research: Decoding DNA  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Genome Research: Decoding DNA Human Genome Research: Decoding DNA Resources with Additional Information Charles DeLisi As head of DOE's Office of Health and Environmental Research, Charles DeLisi played a pivotal role in proposing and initiating the Human Genome Program in 1986. The U.S. Department of Energy (DOE) has historically been active in supporting human genome research. On September 10, 2003, Secretary of Energy Spencer Abraham presented the Secretary's Gold Award to Aristides Patrinos and Francis Collins for their leadership of the government's Human Genome Project. At DOE's Office of Science, Dr. Patrinos is the Associate Director for Biological and Environmental Research. He has been a researcher at the department's Oak Ridge National Laboratory and Brookhaven National Laboratory.

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

GFP Expression in the Mammary Gland for Imaging of Mammary Tumor Cells in Transgenic Mice  

Science Journals Connector (OSTI)

...MMTV) to directly drive expression of GFP, we...was relatively weak and variable in frequency. By crossing MMTV-GFP...terminal repeat is used to drive selective expression...MMTV) to directly drive expression of GFP, we...

Fayyaz Ahmed; Jeffrey Wyckoff; Elaine Y. Lin; Weigang Wang; Yarong Wang; Lothar Hennighausen; Jun-ichi Miyazaki; Joan Jones; Jeffrey W. Pollard; John S. Condeelis; and Jeffrey E. Segall

2002-12-15T23:59:59.000Z

262

Human Reliability Analysis for Digital Human-Machine Interfaces  

SciTech Connect

This paper addresses the fact that existing human reliability analysis (HRA) methods do not provide guidance on digital human-machine interfaces (HMIs). Digital HMIs are becoming ubiquitous in nuclear power operations, whether through control room modernization or new-build control rooms. Legacy analog technologies like instrumentation and control (I&C) systems are costly to support, and vendors no longer develop or support analog technology, which is considered technologically obsolete. Yet, despite the inevitability of digital HMI, no current HRA method provides guidance on how to treat human reliability considerations for digital technologies.

Ronald L. Boring

2014-06-01T23:59:59.000Z

263

Identification of a Gene Containing Zinc-Finger Motifs Based on Lost Expression in Malignantly Transformed Rat Ovarian Surface Epithelial Cells  

Science Journals Connector (OSTI)

...pattern of certain genes, such as p73 and WTI. Here, we have shown that it appears that...and Oshimura, M. Patemal expression of WTI in human fibroblasts and lymphocytes. Hum...Mosaic and polymorphic imprinting of the WTI gene in humans. Nat. Genet., 6: 305-309...

Abbas Abdollahi; Andrew K. Godwin; Paul D. Miller; Lori A. Getts; David C. Schultz; Takahiro Taguchi; Joseph R. Testa; Thomas C. Hamilton

1997-05-15T23:59:59.000Z

264

A framework for human microbiome research  

E-Print Network (OSTI)

A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project ...

Friedman, Jonathan

265

Guest editorial: Special issue on human computing  

E-Print Network (OSTI)

The seven articles in this special issue focus on human computing. Most focus on two challenging issues in human computing, namely, machine analysis of human behavior in group interactions and context-sensitive modeling.

Pantic, Maja

266

Human genome. 1993 Program report  

SciTech Connect

The purpose of this report is to update the Human Genome 1991-92 Program Report and provide new information on the DOE genome program to researchers, program managers, other government agencies, and the interested public. This FY 1993 supplement includes abstracts of 60 new or renewed projects and listings of 112 continuing and 28 completed projects. These two reports, taken together, present the most complete published view of the DOE Human Genome Program through FY 1993. Research is progressing rapidly toward 15-year goals of mapping and sequencing the DNA of each of the 24 different human chromosomes.

Not Available

1994-03-01T23:59:59.000Z

267

Corporate Human Resources Information Services (CHIRS) PIA, Office...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol...

268

Scientists Help Define the Healthy Human Microbiome  

NLE Websites -- All DOE Office Websites (Extended Search)

Scientists Help Define the Healthy Human Microbiome Scientists Help Define the Healthy Human Microbiome Computing, bioinformatics, and microbial ecology resources play key role in...

269

Perception for Human Motion Understanding  

Science Journals Connector (OSTI)

The fact that people are embodied places powerful constraints on their motion. By leveraging these constraints, we can build systems to perceive human motion that are fast and robust. More importantly, by unde...

Christopher R. Wren

2005-01-01T23:59:59.000Z

270

The water footprint of humanity  

Science Journals Connector (OSTI)

...America (the United States, Canada, Brazil, and Argentina...Ehrlich PR ( 1996 ) Human appropriation of renewable fresh water . Science 271 : 785 788 . 6...domestic water supply sector. Water use in energy production is included in the figures...

Arjen Y. Hoekstra; Mesfin M. Mekonnen

2012-01-01T23:59:59.000Z

271

Director Human Resources Assoc Director  

E-Print Network (OSTI)

Director ­ Human Resources Assoc Director Workforce Planning & Organisational Change Director) - Organisational change - Workforce planning - Grievance & performance mgt support - Performance management line and not a formal Branch ** Includes Classifications ANU Search Workforce Planning* Remunerations

Botea, Adi

272

Unravelling daily human mobility motifs  

E-Print Network (OSTI)

Human mobility is differentiated by time scales. While the mechanism for long time scales has been studied, the underlying mechanism on the daily scale is still unrevealed. Here, we uncover the mechanism responsible for ...

Schneider, Christian M.

273

Molecular evolution of human paramyxoviruses  

Science Journals Connector (OSTI)

The nucleotide sequences of the NP and M genes of human parainfluenza type 1 virus (HPIV-1) were determined. The NP gene was 1677 nucleotides long excluding polyadenylic acid. The NP gene contained a single la...

K. Miyahara; S. Kitada; M. Yoshimoto; H. Matsumura; M. Kawano

1992-01-01T23:59:59.000Z

274

HUMAN RESOURCES SIMON FRASER UNIVERSITY  

E-Print Network (OSTI)

. The position is responsible for developing test scenarios, responding to system problems by investigating regarding the design of testing scenarios and scripts and how to evaluate outcomes. Makes decisions1 HUMAN RESOURCES SIMON FRASER UNIVERSITY TEMPORARY ADMINISTRATIVE & PROFESSIONAL STAFF POSITION

275

Posthumanity, Transhumanism and Human Nature  

Science Journals Connector (OSTI)

...Posthumanity has established itself as a label for a form of human existence radically transformed by the most advanced medical techniques and by the use of neuro, bio and nano and other technologies for hum...

Dieter Birnbacher

2009-01-01T23:59:59.000Z

276

Technological Transformation of Human Experience  

Science Journals Connector (OSTI)

This article was inspired by Don Ihde's work on the experience of technology in human-machine relations. (See Don Ihde. "The Experience of Technology," Cultural Hermeneutics, Vol. 2, 1974, pp. 267-279.)

Arun Kumar Tripathi

2008-07-01T23:59:59.000Z

277

The water footprint of humanity  

Science Journals Connector (OSTI)

...the United Arab Emirates (571), Egypt (527...Ehrlich PR ( 1996 ) Human appropriation of renewable fresh water . Science 271 : 785 788 . 6...domestic water supply sector. Water use in energy production is included in the figures...

Arjen Y. Hoekstra; Mesfin M. Mekonnen

2012-01-01T23:59:59.000Z

278

Cordinating human-robot communication  

E-Print Network (OSTI)

As robots begin to emerge from the cloisters of industrial and military applications and enter the realms of coperative partners for people, one of the most important facets of human-robot interaction (HRI) will be ...

Brks, Andrw G. (Brks Zoz)

2007-01-01T23:59:59.000Z

279

The water footprint of humanity  

Science Journals Connector (OSTI)

...the United Arab Emirates (571), Egypt (527...world ( UNESCO , London ). 5 Postel SL Daily GC Ehrlich PR ( 1996 ) Human appropriation of...2008 ) The global component of freshwater demand and supply: An assessment of virtual water...

Arjen Y. Hoekstra; Mesfin M. Mekonnen

2012-01-01T23:59:59.000Z

280

Robot Manipulation in Human Environments  

E-Print Network (OSTI)

Human environments present special challenges for robot manipulation. They are often dynamic, difficult to predict, and beyond the control of a robot engineer. Fortunately, many characteristics of these settings can be ...

Edsinger, Aaron

2007-01-16T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Robot manipulation in human environments  

E-Print Network (OSTI)

Human environments present special challenges for robot manipulation. They are often dynamic, difficult to predict, and beyond the control of a robot engineer. Fortunately, many characteristics of these settings can be ...

Edsinger, Aaron Ladd, 1972-

2007-01-01T23:59:59.000Z

282

Contractor Human Resource Management Programs  

Directives, Delegations, and Requirements

The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09

1996-09-30T23:59:59.000Z

283

Contractor Human Resource Management Programs  

Directives, Delegations, and Requirements

The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09.

1996-09-30T23:59:59.000Z

284

Protection of Human Research Subjects  

Directives, Delegations, and Requirements

The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in Title 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects, 45 CFR Part 46, and the Secretarial Policy Memorandum on Military or Intelligence-Related Human Subject Research, December 9, 2009. Cancels DOE O 443.1A and DOE P 443.1A.

2009-12-09T23:59:59.000Z

285

Human Genome Education Program  

SciTech Connect

The funds from the DOE Human Genome Program, for the project period 2/1/96 through 1/31/98, have provided major support for the curriculum development and field testing efforts for two high school level instructional units: Unit 1, ''Exploring Genetic Conditions: Genes, Culture and Choices''; and Unit 2, ''DNA Snapshots: Peaking at Your DNA''. In the original proposal, they requested DOE support for the partial salary and benefits of a Field Test Coordinator position to: (1) complete the field testing and revision of two high school curriculum units, and (2) initiate the education of teachers using these units. During the project period of this two-year DOE grant, a part-time Field-Test Coordinator was hired (Ms. Geraldine Horsma) and significant progress has been made in both of the original proposal objectives. Field testing for Unit 1 has occurred in over 12 schools (local and non-local sites with diverse student populations). Field testing for Unit 2 has occurred in over 15 schools (local and non-local sites) and will continue in 12-15 schools during the 96-97 school year. For both curricula, field-test sites and site teachers were selected for their interest in genetics education and in hands-on science education. Many of the site teachers had no previous experience with HGEP or the unit under development. Both of these first-year biology curriculum units, which contain genetics, biotechnology, societal, ethical and cultural issues related to HGP, are being implemented in many local and non-local schools (SF Bay Area, Southern California, Nebraska, Hawaii, and Texas) and in programs for teachers. These units will reach over 10,000 students in the SF Bay Area and continues to receive support from local corporate and private philanthropic organizations. Although HGEP unit development is nearing completion for both units, data is still being gathered and analyzed on unit effectiveness and student learning. The final field testing result from this analysis will contribute to the final revisions of each unit during the second-year of this grant.

Richard Myers; Lane Conn

2000-05-01T23:59:59.000Z

286

Shotgun coverage of human genome computing  

E-Print Network (OSTI)

take about 1.5 million pages. The Human Genome Project would not be possible if our revolution were-author collection of chapters on the various uses of computing in the Human Genome Project. Peculiarly absent fromShotgun coverage of human genome computing Human Genome Computing, Second Edition edited by Martin

Eddy, Sean

287

The transcriptional activity of human Chromosome 22  

E-Print Network (OSTI)

information of the human genome is to obtain a detailed knowledge of human transcriptional coding sequences greatly increased our understanding of the biological information encoded on a human chromosome://array.mbb.yale.edu/chr22. [Keywords: Microarray; Chromosome 22; human genome; transcriptome; placental RNA; mouse homology

Gerstein, Mark

288

Course Information IB 364: Human Genome and  

E-Print Network (OSTI)

Course Information IB 364: Human Genome and Bioinformatics On this page: � Course Description � Technical Support Course Description Highlights advances in understanding the human genome, utilizing the human genome, applying bioinformatics to the genome, and realizing its potential to understand human

Kent, Angela

289

SCIENCE, POLITICS. AND THE HUMAN GENOM  

E-Print Network (OSTI)

/ Robert Cook-Deegan. p. cm. Includes bibliographical references. 1. Human Genome Project. 2. Human geneSCIENCE, POLITICS. AND THE HUMAN GENOM A scrupulous . . . narrative of the genesis and opening- DEEGAN #12;#12;#12;#12;The GENE WARS Science, Politics, and theHuman Genome ROBERT COOK-DEEGAN W - W

Richardson, David

290

Low-Income Weatherization: The Human Dimension  

Energy.gov (U.S. Department of Energy (DOE))

This presentation focuses on how the human dimension saves energy within low-income weatherization programs.

291

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network (OSTI)

62 College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES of Architecture, Arts and Humanities offers one-of-a- kind opportunities for interdisciplinary exploration, but the enduring questions. The College of Architecture, Arts and Humanities is organized into three schools

Stuart, Steven J.

292

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network (OSTI)

63 College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES of Architecture, Arts and Humanities offers one-of-a- kind opportunities for interdisciplinary exploration, but the enduring questions. The College of Architecture, Arts and Humanities is organized into three schools

Stuart, Steven J.

293

Virtual humans: back to the future  

Science Journals Connector (OSTI)

This paper essentially tries to examine all the roles that Virtual Humans can play in empowering human expression, and the research challenges we have to face to make this possible. It starts with a short history of Virtual Humans and how we contribute ... Keywords: computer animation, virtual humans, virtual reality

Nadia Magnenat Thalmann; Daniel Thalmann

2012-05-01T23:59:59.000Z

294

The SACADA database for human reliability and human performance  

SciTech Connect

Lack of appropriate and sufficient human performance data has been identified as a key factor affecting human reliability analysis (HRA) quality especially in the estimation of human error probability (HEP). The Scenario Authoring, Characterization, and Debriefing Application (SACADA) database was developed by the U.S. Nuclear Regulatory Commission (NRC) to address this data need. An agreement between NRC and the South Texas Project Nuclear Operating Company (STPNOC) was established to support the SACADA development with aims to make the SACADA tool suitable for implementation in the nuclear power plants' operator training program to collect operator performance information. The collected data would support the STPNOC's operator training program and be shared with the NRC for improving HRA quality. This paper discusses the SACADA data taxonomy, the theoretical foundation, the prospective data to be generated from the SACADA raw data to inform human reliability and human performance, and the considerations on the use of simulator data for HRA. Each SACADA data point consists of two information segments: context and performance results. Context is a characterization of the performance challenges to task success. The performance results are the results of performing the task. The data taxonomy uses a macrocognitive functions model for the framework. At a high level, information is classified according to the macrocognitive functions of detecting the plant abnormality, understanding the abnormality, deciding the response plan, executing the response plan, and team related aspects (i.e., communication, teamwork, and supervision). The data are expected to be useful for analyzing the relations between context, error modes and error causes in human performance.

Y. James Chang; Dennis Bley; Lawrence Criscione; Barry Kirwan; Ali Mosleh; Todd Madary; Rodney Nowell; Robert Richards; Emilie M. Roth; Scott Sieben; Antonios Zoulis

2014-05-01T23:59:59.000Z

295

ATHENA, the Desktop Human "Body"  

ScienceCinema (OSTI)

Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

Iyer, Rashi; Harris, Jennifer

2015-01-05T23:59:59.000Z

296

ATHENA, the Desktop Human "Body"  

SciTech Connect

Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

Iyer, Rashi; Harris, Jennifer

2014-09-29T23:59:59.000Z

297

Human Capital Management | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Human Capital Management Human Capital Management Human Capital Management The strategic management of human capital requires comprehensive planning and analysis in order to develop, implement, and evaluate programs that support every facet of employee work life. DOE human capital initiatives are designed to support continuous improvement and accountability in accordance with the DOE Human Capital Management Accountability Program (HCMAP), which is an internal DOE audit process of servicing human resources offices and addresses those documents that require coordination with the Office of the Chief Human Capital Officer before being implemented; Human Resource Directors; the Department's 5-year Strategic Human Capital Management Plan; Departmental element workforce plans; the Department's personnel accountability program that is used

298

THE HUMAN GENOME & GENETIC DISEASES MED263: Bioinformatic Applications to Human Disease  

E-Print Network (OSTI)

you will learn. History of the human genome project Structure and content of the human genome HapTHE HUMAN GENOME & GENETIC DISEASES MED263: Bioinformatic Applications to Human Disease #12;WhatMap project Categories of Human Disease: Monogenic (Single gene disorders) Multigenic (Complex disorders

Gleeson, Joseph G.

299

WILD PIG ATTACKS ON HUMANS  

SciTech Connect

Attacks on humans by wild pigs (Sus scrofa) have been documented since ancient times. However, studies characterizing these incidents are lacking. In an effort to better understand this phenomenon, information was collected from 412 wild pig attacks on humans. Similar to studies of large predator attacks on humans, data came from a variety of sources. The various attacks compiled occurred in seven zoogeographic realms. Most attacks occurred within the species native range, and specifically in rural areas. The occurrence was highest during the winter months and daylight hours. Most happened under non-hunting circumstances and appeared to be unprovoked. Wounded animals were the chief cause of these attacks in hunting situations. The animals involved were typically solitary, male and large in size. The fate of the wild pigs involved in these attacks varied depending upon the circumstances, however, most escaped uninjured. Most human victims were adult males traveling on foot and alone. The most frequent outcome for these victims was physical contact/mauling. The severity of resulting injuries ranged from minor to fatal. Most of the mauled victims had injuries to only one part of their bodies, with legs/feet being the most frequent body part injured. Injuries were primarily in the form of lacerations and punctures. Fatalities were typically due to blood loss. In some cases, serious infections or toxemia resulted from the injuries. Other species (i.e., pets and livestock) were also accompanying some of the humans during these attacks. The fates of these animals varied from escaping uninjured to being killed. Frequency data on both non-hunting and hunting incidents of wild pig attacks on humans at the Savannah River Site, South Carolina, showed quantitatively that such incidents are rare.

Mayer, J.

2013-04-12T23:59:59.000Z

300

SYT-SSX1 and SYT-SSX2 Interfere with Repression of E-Cadherin by Snail and Slug: A Potential Mechanism for Aberrant Mesenchymal to Epithelial Transition in Human Synovial Sarcoma  

Science Journals Connector (OSTI)

...indicate this fact. 1 dos Santos NR, de Bruijn DRH, Geurts...A, Perez-Moreno MA, Rodrigo I, et al. The transcription...29 de Bruijn DRH, dos Santos NR, Thijssen J, et al...Perez-Moreno MA, Locascio A, Rodrigo I, et al. A new role...

Tsuyoshi Saito; Makoto Nagai; and Marc Ladanyi

2006-07-15T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Acoustics as a Human Science  

Science Journals Connector (OSTI)

There was a time when acoustics was only a human science but this changed as philosophers learned to use mathematical and other measurement tools for ordering and validating their thought processes. This century has seen many changes in the description of the field as a whole and the human aspects continue to be among the most perplexing. The highlights of accomplishments to date some observations on our current status of knowledge and some projections into the future are presented for your entertainmentif not for your information.

S. S. Stevens

1972-01-01T23:59:59.000Z

302

Iris Recognition for Human Identification  

Science Journals Connector (OSTI)

Iris recognition system is the biometric identification system. Iris has an intricate structure uniqueness stability and natural protection. Due to these features of the iris it can be used for biometric identification. This system gives better performance than other biometric identification systems. A novel eyelash removal method for preprocessing of human iris images in a human iris recognition system is presented.. Discrete cosine transform (DCT) method is used for feature extraction. For matching of two?iris code Hamming distance calculation is used. EER value must be less for the optimum performance of the system.

Lajari Alandkar; Sachin Gengaje

2010-01-01T23:59:59.000Z

303

Changes in 2-Hydroxyestrone and 16?-Hydroxyestrone Metabolism with Flaxseed Consumption: Modification by COMT and CYP1B1 Genotype  

Science Journals Connector (OSTI)

...Fishers exact, P 0.006; Kruskal-Wallis ANOVA, P 0.021). ERRa levels...normal mammary epithelial cells (Kruskal-Wallis ANOVA, P 0.001). ERR overexpression...were tested by the nonparametric Kruskal-Wallis ANOVA (Figs. 1 2 3) . Associations...

Susan E. McCann; Jean Wactawski-Wende; Kari Kufel; James Olson; Bladimir Ovando; Susan Nowell Kadlubar; Warren Davis; Lisa Carter; Paola Muti; Peter G. Shields; Jo L. Freudenheim

2007-02-01T23:59:59.000Z

304

Effets de la prolactine sur la scrtion des lipides du lait dans les cellules pithliales mammaires  

E-Print Network (OSTI)

-en-Josas, France. Summary. Effect of prolactin on milk lipid secretion in lactating rabbit mammary gland epithelial secretion. These results show that the radioactivity of neosynthesized lipid constituents was modified during the secretion of milk lipids. Prolactin, which increased the total labelled lipids secreted, had

Boyer, Edmond

305

Effects of Phosphate Bond Energy on Nucleic Acid Stability in Tumor Homogenates  

Science Journals Connector (OSTI)

...A combination of detailed energy balance phenotyping and measures...AL+EX groups separately). Energy balance phenotyping Mice in...refs. 30, 31) using dual-energy X-ray absorptiometry (GE...mammary glands, including a mix of epithelial cells, adipocytes...

G. A. LePage

1949-05-01T23:59:59.000Z

306

The Psychology of Human Behavior  

Science Journals Connector (OSTI)

... THE author of The Psychology of Human Behavior is to be congratulated on the production of an extremely readable ... congratulated on the production of an extremely readable and well-constructed elementary text-book of psychology. The addition of questions for discussion at the end of each chapter is a ...

1936-11-14T23:59:59.000Z

307

Biodiversity in Human-Impacted  

E-Print Network (OSTI)

1 #12;1 Biodiversity in Human-Impacted Landscapes Biodiversidad en Paisajes Intervenidos Volumen-1 complex and dynamic. Traditionally, efforts to protect biodiversity and address environmental problems abilities of policy makers and on-the-ground practitioners is essential to biodiversity conservation

Haller, Gary L.

308

EMERGENCY HIRE GUIDELINES HUMAN RESOURCES  

E-Print Network (OSTI)

EMERGENCY HIRE GUIDELINES HUMAN RESOURCES Workforce Planning · One Washington Square · San José, Ca: Workforce Planning; Sr. Workforce Planning Analyst DATE: May 2, 2008 I. PURPOSE / DESCRIPTION The Emergency. B. The Workforce Planning Analyst will work with the hiring manager/HR contact to identify and hire

Su, Xiao

309

Reverse engineering the human brain  

Science Journals Connector (OSTI)

...Thompson Reverse engineering the human brain Vincent Walsh Department of Experimental...can be used to temporarily prevent the brain from carrying out some of its normal functions...outline some of the advances in understanding brain function made by using TMS, and, in particular...

2000-01-01T23:59:59.000Z

310

Cognitive Engineering Automation and Human  

E-Print Network (OSTI)

· Home automation · Robotics · Unmanned vehicles (UAVs and UGVs) · Drug design/Molecular geneticsCognitive Engineering PSYC 530 Automation and Human Performance Raja Parasuraman #12;Overview Automation-Related Accidents Levels and Stages of Automation Information Acquisition and Analysis Decision

Parasuraman, Raja

311

NCSU Human Resources Training & Organizational  

E-Print Network (OSTI)

2011 NCSU Human Resources Training & Organizational Development Spring & Summer 2011 Learning to Training & Organizational Development's new eLearning Training Catalog. This catalog serves as a central information regarding: Participating Units and Who To Contact Certificate Programs Courses and Sessions eLearning

312

A human body analysis system  

Science Journals Connector (OSTI)

This paper describes a system for human body analysis (segmentation, tracking, face/hands localisation, posture recognition) from a single view that is fast and completely automatic. The system first extracts low-level data and uses part of the data ...

Vincent Girondel; Laurent Bonnaud; Alice Caplier

2006-01-01T23:59:59.000Z

313

Human Cognitive Neuropsychology PROGRAMME HANDBOOK  

E-Print Network (OSTI)

, but the handbook does not form part of any contract between University and student. 1. Arrival and OrientationMSc/Dip in Human Cognitive Neuropsychology PROGRAMME HANDBOOK 2011/2012 Psychology School) the University Regulations, (b) the Code of Practice, and (c) the Taught Masters Handbook for the School

Edinburgh, University of

314

Contractor Human Resources | National Nuclear Security Administration  

NLE Websites -- All DOE Office Websites (Extended Search)

Contractor Human Resources | National Nuclear Security Administration Contractor Human Resources | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Contractor Human Resources Home > About Us > Our Operations > Acquisition and Project Management > Contractor Human Resources Contractor Human Resources Welcome The Contractor Human Resources mission is to provide expert advice and

315

Porcine adenovirus serotype 3 internalization is independent of CAR and ?v?3 or ?v?5 integrin  

Science Journals Connector (OSTI)

Nonhuman adenoviruses including porcine adenovirus serotype 3 (PAd3) are emerging vectors for gene delivery. \\{PAd3\\} efficiently transduces human and murine cells in culture, and circumvents preexisting humoral immunity in humans. The coxsackievirusadenovirus receptor (CAR) serves as a primary receptor and ?v?3 or ?v?5 integrin as a secondary receptor for several human adenovirus (HAd) subtypes including HAd5. In this study, we deduced the role of CAR, ?v?3 or ?v?5 integrin in \\{PAd3\\} internalization. Transduction experiments were conducted in human mammary epithelial (MCF-10A) cells using replication-defective PAd-GFP (PAd3 vector expressing green fluorescent protein [GFP]) and HAd-GFP (HAd5 vector expressing GFP). MCF-10A cells were treated with or without anti-human CAR, or anti-?v?3 or anti-?v?5 integrin antibodies prior to infection with HAd-GFP or PAd-GFP. Significant (P CAR- as well as ?v?3 or ?v?5 integrin-independent and the primary receptor for \\{HAd5\\} and \\{PAd3\\} were distinct. CAR- and ?v?3 or ?v?5 integrin-independent entry of \\{PAd3\\} vectors may have implications in targeting cell types that are not efficiently transduced by other adenoviral vectors.

Dinesh S. Bangari; Suresh K. Mittal

2005-01-01T23:59:59.000Z

316

Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-{alpha}-positive human cells  

SciTech Connect

Bisphenol-A (BPA) shows proliferative actions in uterus and mammary glands and may influence the development of male and female reproductive tracts in utero or during early postnatal life. Because of its ability to function as an estrogen receptor (ER) agonist, BPA has the potential to disrupt normal endocrine signaling through regulation of ER target genes. Some genes are regulated by both estradiol (E2) and BPA, but those exclusive to either agent have not been described. Using a yeast strain incorporating a vitellogenin A2 ERE-LacZ reporter gene into the genome, we found that BPA induced expression of the reporter in colonies transformed with the ER{alpha} expression plasmid, illustrating BPA-mediated regulation within a chromatin context. Additionally, a reporter gene transiently transfected into the endometrial cancer (Ishikawa) cell line also showed BPA activity, although at 100-fold less potency than E2. To compare global gene expression in response to BPA and E2, we used a variant of the MCF-7 breast cancer cell line stably expressing HA-tagged ER{alpha}. Cultures were treated for 3 h with an ethanol vehicle, E2 (10{sup -8} M), or BPA (10{sup -6} M), followed by isolation of RNA and microarray analysis with the human U95A probe array (Affymetrix, Santa Clara, CA, USA). More than 300 genes were changed 2-fold or more by either or both agents, with roughly half being up-regulated and half down-regulated. A number of growth- and development-related genes, such as HOXC1 and C6, Wnt5A, Frizzled, TGF{beta}-2, and STAT inhibitor 2, were found to be affected exclusively by BPA. We used quantitative real-time PCR to verify regulation of the HOXC6 gene, which showed decreased expression of approximately 2.5-fold by BPA. These results reveal novel effects by BPA and E2, raising interesting possibilities regarding the role of endocrine disruptors in sexual development.

Singleton, David W. [Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267-0521 (United States); Feng, Yuxin [Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267-0521 (United States); Yang, Jun [Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267-0521 (United States); Puga, Alvaro [Department of Environmental Health, University of Cincinnati, Cincinnati, OH (United States); Lee, Adrian V. [Baylor College of Medicine, Houston, TX (United States); Khan, Sohaib A. [Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267-0521 (United States)]. E-mail: sohaib.khan@uc.edu

2006-01-15T23:59:59.000Z

317

Synthesizing Human Motion from Intuitive Constraints  

Science Journals Connector (OSTI)

Many compelling applications would become feasible if novice users had the ability to synthesize high quality human motion based only on a simple sketch and ... proven to be a powerful tool for synthesizing human motion

Alla Safonova; Jessica K. Hodgins

2008-01-01T23:59:59.000Z

318

Human adaptation of avian influenza viruses  

E-Print Network (OSTI)

Human adaptation of avian influenza viruses pose an enormous public health challenge as the human population is predominantly naive to avian influenza antigens. As such, constant surveillance is needed to monitor the ...

Srinivasan, Karunya

2012-01-01T23:59:59.000Z

319

What Does It Mean to Be Human?  

Science Journals Connector (OSTI)

Humans are the highest form of intelligent life on Earth. But what is it that makes us distinctly human? From a purely scientific perspective, what, if anything, sets us apart from other forms of life? Are the...

Barry B. Luokkala

2014-01-01T23:59:59.000Z

320

Propeller based human powered swimming device  

E-Print Network (OSTI)

Currently the only human powered swimming device widely sold on the market are swim flippers. However, flippers are not efficient for the human body, and there is a potential to increase the speed while swimming with a ...

Bunker, Kristine (Kristine Alina)

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Video looping of human cyclic motion  

E-Print Network (OSTI)

In this thesis, a system called Video Looping is developed to analyze human cyclic motions. Video Looping allows users to extract human cyclic motion from a given video sequence. This system analyzes similarities from a large amount of live footage...

Choi, Hye Mee

2004-09-30T23:59:59.000Z

322

Human Brain vs. Computer | GE Global Research  

NLE Websites -- All DOE Office Websites (Extended Search)

Computer Processors Beat the Human Mind in the Future? Can Computer Processors Beat the Human Mind in the Future? 2013.01.29 Chief Scientist Jim Bray takes on this question that...

323

6.20 Mapping Human Brain Function  

NLE Websites -- All DOE Office Websites (Extended Search)

0 612011 6.20 Mapping Human Brain Function Many mysteries of the human brain have been unraveled by positron emission tomography (PET), an imaging tool used worldwide to diagnose...

324

Workshop Reports Understanding Paleoclimate and Human Evolution  

E-Print Network (OSTI)

, involving research in anthropology, archaeology, human genetics and genomics, and the earth sciences resolved paleoenvironmental information. This concept is not new. Almost thirty years ago, the U.SWorkshop Reports Understanding Paleoclimate and Human Evolution Through the Hominin Sites

Reiners, Peter W.

325

Abstract 5551: Role of YB-1, a regulator of epithelial to mesenchymal transition, in prostate cancer: inhibition by a dietary flavonoid fisetin.  

Science Journals Connector (OSTI)

...family proteins by the dietary compound fisetin in HCT-116 human colon cancer cells...14-18, 2007; Los Angeles, CA 4982 Fisetin, 3,3',4',7-tetrahydroxyflavone...activity. We have previously observed that fisetin inhibits the proliferation of HT-29...

Vaqar Mustafa Adhami; Mohammad Imran Khan; Rahul K. Lall; Imtiaz A. Siddiqui; Deeba N. Syed; Mario Sechi; Shah-Jahan M. Dodwad; Hasan Mukhtar

2013-04-15T23:59:59.000Z

326

In Vitro Perfused Human Capillary Networks  

E-Print Network (OSTI)

during vessel network formation, micro- spheres traversedof a living network of dynamic human capillaries in a micro-

Moya, Monica L.; Hsu, Yu-Hsiang; Lee, Abraham P.; Hughes, Christopher C.W.; George, Steven C.

2013-01-01T23:59:59.000Z

327

Careers/ Human Resources | Princeton Plasma Physics Lab  

NLE Websites -- All DOE Office Websites (Extended Search)

Employment Opportunities Environment, Safety & Health Procurement Division Technology Transfer Furth Plasma Physics Library Contact Us Lab Leadership Directory Careers Human...

328

GDB - Human Genome Database final report  

SciTech Connect

This is the DOE final report for the GDB, Human Genome Database, project at the Johns Hopkins University.

Talbot, C. Conover, Jr.

2002-01-08T23:59:59.000Z

329

2014 DOE Human Reliability Program (HRP) Workshop | Department...  

Office of Environmental Management (EM)

DOE Human Reliability Program (HRP) Workshop 2014 DOE Human Reliability Program (HRP) Workshop August 18, 2014 - 7:51am Addthis 2014 DOE Human Reliability Program (HRP) Workshop...

330

PIA - Human Resources Management System | Department of Energy  

Office of Environmental Management (EM)

System PIA - Human Resources Management System More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - Human Resources - Personal Information Change...

331

Contractor Human Resource Management Programs  

Directives, Delegations, and Requirements

This directive establishes DOE responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. DOE O 350.1 Chg 5, dated 9-30-2014, cancels Chapters I-III of DOE O 350.1 Chg 4

1996-09-29T23:59:59.000Z

332

Contractor Human Resource Management Programs  

Directives, Delegations, and Requirements

The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. This order cancels DOE O 3220.1A, DOE O 3220.4A, DOE O 3220.6A, and DOE O 3309.1A.

1996-09-30T23:59:59.000Z

333

Learning Human Motion Models Bulent Tastan  

E-Print Network (OSTI)

Learning Human Motion Models Bulent Tastan Department of EECS University of Central Florida Orlando In this summary, I provide an overview of my disserta- tion work on learning human motion models from trajectory) pursuing opponents. Human Tracking One of the most powerful constraints governing many ac- tivity

Sukthankar, Gita Reese

334

Policy Title: Human Subject Responsible Office: UFS  

E-Print Network (OSTI)

Policy Title: Human Subject Payments Responsible Office: UFS HARVARD UNIVERSITY FINANCIAL POLICY Effective Date: 1/1/11 Revision Date: N/A HUMAN SUBJECT PAYMENTS Policy Number TAX102 HARVARD UNIVERSITY FINANCIAL POLICY POLICY STATEMENT Individuals conducting Harvard research studies that compensate human

Chen, Yiling

335

Casein Production by Human Breast Cancer  

Science Journals Connector (OSTI)

...human breast cancers. Casein production by human breast cancer...Thus it appears that casein production is not a common characteristic...magnesium, by scraping with a rubber policeman and collected by...sulfate. MARCH 1977 749 Casein Production by Human Breast Cancer Marie...

Marie E. Monaco; Diane A. Bronzert; Douglass C. Tormey; Phillip Waalkes; and Marc E. Lippman

1977-03-01T23:59:59.000Z

336

INVESTIGATION Inferring Admixture Histories of Human Populations  

E-Print Network (OSTI)

and apply to test for admixture among all populations from the Human Genome Diversity Project (HGDPINVESTIGATION Inferring Admixture Histories of Human Populations Using Linkage Disequilibrium Po-range migrations and the resulting admixtures between populations have been important forces shaping human genetic

Reich, David

337

Genomic Comparisons of Humans and Chimpanzees  

E-Print Network (OSTI)

Genomic Comparisons of Humans and Chimpanzees Ajit Varki1 and David L. Nelson2 1 Glycobiology to human evolution, development, and disease. Sequence differences from the human genome were confirmed in the sidebar Online Sources of Information Regarding the Chimpanzee Genome. At the outset, we also emphasize

338

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network (OSTI)

College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES The College of Architecture, Arts and Humanities offers graduate programs in three schools: the School in Architecture; City and Regional Planning; Construction Science and Management; Digital Pro- duction Arts

Stuart, Steven J.

339

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network (OSTI)

25 College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES The College of Architecture, Arts and Humanities offers graduate programs in three schools: the School in Architecture; City and Regional Planning; Construction Science and Management; Digital Pro- duction Arts

Stuart, Steven J.

340

College of Architecture, Arts, and Humanities ARCHITECTURE,  

E-Print Network (OSTI)

56 College of Architecture, Arts, and Humanities 56 COLLEGE OF ARCHITECTURE, ARTS, AND HUMANITIES The collaboration of Architecture (Landscape Ar- chitecture, Construction Science and Management, City and Regional Planning, and Architecture) with Arts (Visual Arts and Performing Arts) and the Humanities (Communication

Stuart, Steven J.

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

College of Architecture, Arts, and Humanities ARCHITECTURE,  

E-Print Network (OSTI)

57 College of Architecture, Arts, and Humanities COLLEGE OF ARCHITECTURE, ARTS, AND HUMANITIES The collaboration of Architecture (Landscape Ar- chitecture, Construction Science and Management, City and Regional Planning, and Architecture) with Arts (Visual Arts and Performing Arts) and the Humanities (Communication

Stuart, Steven J.

342

The need for a human gene index  

Science Journals Connector (OSTI)

......need for a human gene index. | Editorial | Abstracting...NEED FOR A HUMAN GENE INDEX Much noise has been made...the year 2000 about the completion of a "draft" of the...changes in assembly and completion of the draft genome...need for a human gene index Towards a true gene index......

C. Victor Jongeneel

2000-12-01T23:59:59.000Z

343

Reflections on the human prospect  

SciTech Connect

World population and the global economy are expanding in a manner that is propelling civilization along a path that is unsustainable, inequitable, and unstable. A concerted, global effort to discover, integrate, disseminate, and apply knowledge about the natural world and human behavior would change this trajectory to a path of sustainable human development. This path would point toward the vision of a society in which the basic human needs and an equitable share of life`s amenities could be met by successive generations while maintaining in perpetuity a health, physically attractive, and biologically productive environment. The scholarly community is urged to provide impetus for the pursuit of this vision. An unprecedented degree of collaboration among the disciplines will be necessary. New modes of communication and cooperation among the major sectors of society will have to be fashioned. Knowledge will become an organizing principle for society in the twenty-first century. Climate change has resulted from continuing economic and demographic growth. To stabilize world climate, the emission of greenhouse gases must be controlled. 57 refs.

Malone, T.F. [Sigma Xi Center, Research Triangle Park, NC (United States); [North Carolina State Univ., Raleigh, NC (United States)

1995-11-01T23:59:59.000Z

344

Research on digital human model used in human factor simulation and evaluation of load carriage equipment  

Science Journals Connector (OSTI)

Data structure of the digital human model has been constructed for particularity demand of human factor evaluation of the load carriage system equipments. Anthropometry data of different percentage was obtained through regression calculation; Range of ... Keywords: digital human model, human factors, load carriage equipment, simulation

Dayong Dong; Lijing Wang; Xiugan Yuan; Shan Fu

2011-07-01T23:59:59.000Z

345

Interactive Manipulation Between a Human and a Humanoid: When Robots Control Human Arm Motion  

E-Print Network (OSTI)

Interactive Manipulation Between a Human and a Humanoid: When Robots Control Human Arm Motion Bruno a novel approach in human/robot collaboration, where the robot controls not only its arm but also our previous framework [5] to the case where the robot controls both its arm and the human's in order

Boyer, Edmond

346

The Humanity of the Human Body: Is Homo Cybersapien a New Species?  

Science Journals Connector (OSTI)

The importance of the human body within traditional bioethical debates is amplified within the field of technoethics as scholars attempt to grapple with conflicting views of what it means to be human and what attributes are core to human beings within ... Keywords: Freedom, Human Body, Modernity, Postmodernity, Science, Technoethics

Rocci Luppicini; Jos M. Galvn

2012-04-01T23:59:59.000Z

347

The LIRIS Human activities dataset and the ICPR 2012 human activities recognition and localization competition  

E-Print Network (OSTI)

The LIRIS Human activities dataset and the ICPR 2012 human activities recognition and localization-69621, France March 28, 2012 Abstract We describe the LIRIS human activities dataset, the dataset used competitions and existing datasets, the tasks focus on complex human behavior involving several people

Wolf, Christian

348

Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor ?B  

Science Journals Connector (OSTI)

...2):675-83] snake venom toxin|Vipera...implicated in tumor development and resistance to...cancer cell death. Snake venom toxins (SVT...in PBS) at room temperature for 2 h. The cells...during mammary gland development. Cell 2001;107...Chung KH, Kim DS. Snake venom disintegrin...

Dong Ju Son; Mi Hee Park; Sang Jin Chae; Soon Ok Moon; Jae Woong Lee; Ho Sueb Song; Dong Cheul Moon; Sang Sun Kang; Young Ee Kwon; and Jin Tae Hong

2007-02-01T23:59:59.000Z

349

Calcitriol inhibits Ether-a go-go potassium channel expression and cell proliferation in human breast cancer cells  

SciTech Connect

Antiproliferative actions of calcitriol have been shown to occur in many cell types; however, little is known regarding the molecular basis of this process in breast carcinoma. Ether-a-go-go (Eag1) potassium channels promote oncogenesis and are implicated in breast cancer cell proliferation. Since calcitriol displays antineoplastic effects while Eag1 promotes tumorigenesis, and both factors antagonically regulate cell cycle progression, we investigated a possible regulatory effect of calcitriol upon Eag1 as a mean to uncover new molecular events involved in the antiproliferative activity of this hormone in human breast tumor-derived cells. RT real-time PCR and immunocytochemistry showed that calcitriol suppressed Eag1 expression by a vitamin D receptor (VDR)-dependent mechanism. This effect was accompanied by inhibition of cell proliferation, which was potentiated by astemizole, a nonspecific Eag1 inhibitor. Immunohistochemistry and Western blot demonstrated that Eag1 and VDR abundance was higher in invasive-ductal carcinoma than in fibroadenoma, and immunoreactivity of both proteins was located in ductal epithelial cells. Our results provide evidence of a novel mechanism involved in the antiproliferative effects of calcitriol and highlight VDR as a cancer therapeutic target for breast cancer treatment and prevention.

Garcia-Becerra, Rocio [Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico, D.F. (Mexico)] [Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico, D.F. (Mexico); Diaz, Lorenza, E-mail: lorenzadiaz@gmail.com [Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico, D.F. (Mexico)] [Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico, D.F. (Mexico); Camacho, Javier [Department of Pharmacology, Centro de Investigacion y de Estudios Avanzados, Instituto Politecnico Nacional, Av. Instituto Politecnico Nacional 2508, San Pedro Zacatenco 07360, Mexico, D.F. (Mexico)] [Department of Pharmacology, Centro de Investigacion y de Estudios Avanzados, Instituto Politecnico Nacional, Av. Instituto Politecnico Nacional 2508, San Pedro Zacatenco 07360, Mexico, D.F. (Mexico); Barrera, David; Ordaz-Rosado, David; Morales, Angelica [Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico, D.F. (Mexico)] [Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico, D.F. (Mexico); Ortiz, Cindy Sharon [Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico, D.F. (Mexico)] [Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico, D.F. (Mexico); Avila, Euclides [Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico, D.F. (Mexico)] [Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico, D.F. (Mexico); Bargallo, Enrique [Department of Breast Tumors, Instituto Nacional de Cancerologia, Av. San Fernando No. 22, Tlalpan 14080, Mexico, D.F. (Mexico)] [Department of Breast Tumors, Instituto Nacional de Cancerologia, Av. San Fernando No. 22, Tlalpan 14080, Mexico, D.F. (Mexico); Arrecillas, Myrna [Department of Pathology, Instituto Nacional de Cancerologia, Av. San Fernando No. 22, Tlalpan 14080, Mexico, D.F. (Mexico)] [Department of Pathology, Instituto Nacional de Cancerologia, Av. San Fernando No. 22, Tlalpan 14080, Mexico, D.F. (Mexico); Halhali, Ali; Larrea, Fernando [Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico, D.F. (Mexico)] [Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No. 15, Tlalpan 14000 Mexico, D.F. (Mexico)

2010-02-01T23:59:59.000Z

350

Climate Human Capital | Open Energy Information  

Open Energy Info (EERE)

Climate Human Capital Climate Human Capital Jump to: navigation, search Name Climate Human Capital Place London, United Kingdom Zip W1K 6NG Sector Carbon, Renewable Energy, Services Product Green executive search company, listed in London's PLUS marketplace since 30 MArch 2010, focusing on the following target sectors: Carbon Markets, Environmental Sciences, Research and Advisory, Financial Services, Renewable Energy Generation and Policy. References Climate Human Capital[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Climate Human Capital is a company located in London, United Kingdom . References ↑ "Climate Human Capital" Retrieved from "http://en.openei.org/w/index.php?title=Climate_Human_Capital&oldid=343709

351

PIA - INL PeopleSoft - Human Resource System | Department of...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

PIA - INL PeopleSoft - Human Resource System PIA - INL PeopleSoft - Human Resource System PIA - INL PeopleSoft - Human Resource System PIA - INL PeopleSoft - Human Resource System...

352

Human Resources & Occupational Medicine  

NLE Websites -- All DOE Office Websites (Extended Search)

Job Opportunities Benefits Office • Work-Life Balance Programs • International Services • Occupational Medicine • Salaries & Awards • Training & Qualifications The Human Resources and Occupational Medicine Division handles scientific and non-scientific employment, benefits, employee and labor relations, staff development, salaries and awards, employee records, and occupational medicine. For more information, click on the one of the services listed above. Brookhaven National Laboratory has a long-standing commitment to a policy of equal opportunity and diversity. Our goal is equality of opportunity in all aspects of employment, including placement, development programs, job assignments, transfers and promotions, without regard to race, color,

353

Simulation of human decision making  

DOE Patents (OSTI)

A method for computer emulation of human decision making defines a plurality of concepts related to a domain and a plurality of situations related to the domain, where each situation is a combination of at least two of the concepts. Each concept and situation is represented in the computer as an oscillator output, and each situation and concept oscillator output is distinguishable from all other oscillator outputs. Information is input to the computer representative of detected concepts, and the computer compares the detected concepts with the stored situations to determine if a situation has occurred.

Forsythe, J. Chris (Sandia Park, NM); Speed, Ann E. (Albuquerque, NM); Jordan, Sabina E. (Albuquerque, NM); Xavier, Patrick G. (Albuquerque, NM)

2008-05-06T23:59:59.000Z

354

Contractor Human Resource Management Programs  

Directives, Delegations, and Requirements

This directive establishes DOE responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. DOE O 350.1 Chg 5, dated 9-30-2014, cancels DOE O 350.1 Chg 4. The Order is revised to reflect the cancellation of Chapters 1-3 due to the incorporation of these chapters into DOE Order 350.3; reflect organizational changes; delete reference to the DOE Retrospective Rating Insurance Plan, which is no longer available; remove the CRD from Chapter VII.

1996-09-30T23:59:59.000Z

355

Structural Stability of Human Fibroblast Growth Factor-1 Is Essential for Protective Effects Against Radiation-Induced Intestinal Damage  

SciTech Connect

Purpose: Human fibroblast growth factor-1 (FGF1) has radioprotective effects on the intestine, although its structural instability limits its potential for practical use. Several stable FGF1 mutants were created increasing stability in the order, wild-type FGF1, single mutants (Q40P, S47I, and H93G), Q40P/S47I, and Q40P/S47I/H93G. This study evaluated the contribution of the structural stability of FGF1 to its radioprotective effect. Methods and Materials: Each FGF1 mutant was administered intraperitoneally to BALB/c mice in the absence of heparin 24 h before or after total body irradiation (TBI) with {gamma}-rays at 8-12 Gy. Several radioprotective effects were examined in the jejunum. Results: Q40P/S47I/H93G could activate all subtypes of FGF receptors in vitro much more strongly than the wild-type without endogenous or exogenous heparin. Preirradiation treatment with Q40P/S47I/H93G significantly increased crypt survival more than wild-type FGF1 after TBI at 10 or 12 Gy, and postirradiation treatment with Q40P/S47I/H93G was effective in promoting crypt survival after TBI at 10, 11, or 12 Gy. In addition, crypt cell proliferation, crypt depth, and epithelial differentiation were significantly promoted by postirradiation treatment with Q40P/S47I/H93G. The level of stability of FGF1 mutants correlated with their mitogenic activities in vitro in the absence of heparin; however, preirradiation treatment with the mutants increased the crypt number to almost the same level as Q40P/S47I/H93G. When given 24 h after TBI at 10 Gy, all FGF1 mutants increased crypt survival more than wild-type FGF1, and Q40P/S47I/H93G had the strongest mitogenic effects in intestinal epithelial cells after radiation damage. Moreover, Q40P/S47I/H93G prolonged mouse survival after TBI because of the repair of intestinal damage. Conclusion: These findings suggest that the structural stability of FGF1 can contribute to the enhancement of protective effects against radiation-induced intestinal damage. Therefore, Q40P/S47I/H93G is pharmacologically one of the most promising candidates for clinical applications for radiation-induced gastrointestinal syndrome.

Nakayama, Fumiaki, E-mail: f_naka@nirs.go.jp [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan)] [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Umeda, Sachiko [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan)] [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan); Yasuda, Takeshi [Department of Radiation Emergency Medicine, Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba (Japan)] [Department of Radiation Emergency Medicine, Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba (Japan); Asada, Masahiro; Motomura, Kaori; Suzuki, Masashi [Signaling Molecules Research Laboratory, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki (Japan)] [Signaling Molecules Research Laboratory, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki (Japan); Zakrzewska, Malgorzata [Faculty of Biotechnology, University of Wroclaw (Poland)] [Faculty of Biotechnology, University of Wroclaw (Poland); Imamura, Toru [Signaling Molecules Research Laboratory, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki (Japan)] [Signaling Molecules Research Laboratory, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki (Japan); Imai, Takashi [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan)] [Advanced Radiation Biology Research Program, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba (Japan)

2013-02-01T23:59:59.000Z

356

Solar radiation and human health  

Science Journals Connector (OSTI)

The Sun has played a major role in the development of life on Earth. In Western culture, people are warned against Sun exposure because of its adverse effects: erythema, photoimmunosuppression, photoageing, photocarcinogenesis, cataracts and photokeratitis. However, Sun exposure is also beneficial, since moderate doses give beneficial physiological effects: vitamin D synthesis, reduction of blood pressure and mental health. Shortage of Sun exposure may be even more dangerous to human health than excessive exposure. Avoiding Sun exposure leads to vitamin D deficiency which is associated not only with rickets and osteomalacia, but also with increased risk of cardiovascular disease, multiple sclerosis, rheumatoid arthritis, diabetes, influenza, many types of cancer and adverse pregnancy outcomes. Solar radiation induces nitric oxide release in tissue and immediate pigment darkening which certainly play important roles, although these are still unknown. Action spectra relevant for health are described. We will also review what is known about spectral and intensity variations of terrestrial solar radiation as well as its penetration through the atmosphere and into human skin and tissue.

Asta Juzeniene; Pl Brekke; Arne Dahlback; Stefan Andersson-Engels; Jrg Reichrath; Kristin Moan; Michael F Holick; William B Grant; Johan Moan

2011-01-01T23:59:59.000Z

357

China and the Humanities: At the Crossroads of the Human and the Humane  

E-Print Network (OSTI)

to legitimatize their own rule. However unlike the Manchu rulers, his analysis reveals only a dark portent for the future of Chinese civilization. Part Three Humanities Mark on People |???????? The five chapters of part three of this volume revolve around... or Virginia Woolf Academic Web] (http://globe.eworkway.com) that provides an im- portant on-line venue for Chinese academics and readers who are devoted to the life and works of Virginia Woolf. Judy LATTAS Judy Lattas is the Director of the Interdisciplinary...

Tchou, W. Kang

2013-01-01T23:59:59.000Z

358

Human Resources | National Nuclear Security Administration  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Resources | National Nuclear Security Administration Human Resources | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Human Resources Home > About Us > Our Operations > Management and Budget > Human Resources Human Resources The Human Resources function in NNSA is a vital partnership between all levels of NNSA management. It requires effective collaboration with the

359

Human Resources | National Nuclear Security Administration  

National Nuclear Security Administration (NNSA)

Human Resources | National Nuclear Security Administration Human Resources | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Human Resources Home > About Us > Our Operations > Management and Budget > Human Resources Human Resources The Human Resources function in NNSA is a vital partnership between all levels of NNSA management. It requires effective collaboration with the

360

Can Robots and Humans Get Along?  

SciTech Connect

Now that robots have moved into the mainstreamas vacuum cleaners, lawn mowers, autonomous vehicles, tour guides, and even petsit is important to consider how everyday people will interact with them. A robot is really just a computer, but many researchers are beginning to understand that human-robot interactions are much different than human-computer interactions. So while the metrics used to evaluate the human-computer interaction (usability of the software interface in terms of time, accuracy, and user satisfaction) may also be appropriate for human-robot interactions, we need to determine whether there are additional metrics that should be considered.

Scholtz, Jean

2007-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

PIA - Human Resources - Personal Information Change Request ...  

Office of Environmental Management (EM)

Request - Idaho National Engineering Laboratory More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - INL SECURITY INFORMATION MANAGEMENT SYSTEM...

362

Human Health Science Building Geothermal Heat Pumps  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

HUMAN HEALTH SCIENCE BLDG GEO HEAT PUMP SYSTEMS Principal Investigator Source Heat Pumps Demo Projects May 20, 2010 This presentation does not contain any proprietary confidential,...

363

Human Capital Management Accountability Program (HCMAP)  

Energy.gov (U.S. Department of Energy (DOE))

Human Capital Management Accountability Program (HCMAP) is an online program which serves as the vehicle for identifying and measuring these three factors, effectiveness, efficiency, and timeliness...

364

Apparatus and methods for a human extender  

DOE Patents (OSTI)

A human extender controller for interface between a human operator and a physical object through a physical plant. The human extender controller uses an inner-feedback loop to increase the equivalent damping of the operating system to stabilize the system when it contacts with the environment and reduces the impact of the environment variation by utilizing a high feedback gain, determined by a root locus sketch. Because the stability of the human extender controller of the present invention is greatly enhanced over that of the prior art, the present invention is able to achieve a force reflection ratio 500 to 1 and capable of handling loads above the two (2) ton range.

Jansen, John F. (Knoxville, TN)

2001-01-01T23:59:59.000Z

365

Essays on Human Development and Public Policy  

E-Print Network (OSTI)

52, January 2003. [54] Amartya Sen. Editorial: Human capitalapproach is advocated by Amartya Sen (1997) greater control1961, December 1997. [55] Amartya K Sen. Poverty: An ordinal

Raykar, Neha

2011-01-01T23:59:59.000Z

366

Mimicking human-drawn pencil lines.  

E-Print Network (OSTI)

??In applications such as architecture, early design sketches containing accurate line drawings often mislead the target audience [Schumann et al. 1996]. Approximate human-drawn sketches are (more)

Al-Meraj, Zainab Faisal

2008-01-01T23:59:59.000Z

367

Power Generation and Human Health  

Science Journals Connector (OSTI)

Emissions from power generation are associated with adverse health and ecological effects. Fossil fuel-based power plants (such as coal, oil, and to a lesser extent, natural gas) are associated with emissions of particulate matter (PM), nitrogen oxides (NOx), sulfur dioxide (SO2), and a variety of organic contaminants such as mercury and volatile organic compounds (VOCs). Exposure to emissions from power plants has been associated with a variety of respiratory symptoms, typically based on short-term (e.g., from 510min to 24h) increases in ambient concentrations. In addition, exposure to constituents from emissions generated by fossil fuels has been associated with increases in premature mortality, particularly in the elderly, and a variety of respiratory and cardiovascular illnesses. Fossil fuels, particularly coal-fired power plants, are responsible for generating the majority of emissions to which humans are exposed.

K. von Stackelberg

2011-01-01T23:59:59.000Z

368

HETHR -Harvard Ethics Training in Human Research Harvard Ethics Training in Human Research  

E-Print Network (OSTI)

HETHR - Harvard Ethics Training in Human Research Harvard Ethics Training in Human Research of the Harvard Ethics Training in Human Research (HETHR) curriculum. This certification is effective on 01 and the following required topics: · History · Definitions · Ethical Principles · Informed Consent · Regulations

Church, George M.

369

Decision-Making Authority, Team Efficiency and Human Worker Satisfaction in Mixed Human-Robot Teams  

E-Print Network (OSTI)

Decision-Making Authority, Team Efficiency and Human Worker Satisfaction in Mixed Human-Robot Teams@csail.mit.edu Abstract-- In manufacturing, advanced robotic technology has opened up the possibility of integrating highly autonomous mobile robots into human teams. However, with this capability comes the issue of how

Reif, Rafael

370

College of Health and Human Sciences College of Health and Human  

E-Print Network (OSTI)

Sciences Office in L.L. Gibbons Building, Room 217 (970) 491-6331 www.chhs.colostate.edu Professor Jeff McCollege of Health and Human Sciences _______________ 2.8 Page 1 College of Health and Human Management Family and Consumer Sciences Fermentation Science and Technology Health and Exercise Science Human

371

The human genome project has revealed the DNA sequence that governs all biological processes in humans  

E-Print Network (OSTI)

The human genome project has revealed the DNA sequence that governs all biological processes step in the process of characterizing the human genome is the identification of genes. This prob- lem IN THE HUMAN GENOME We have been mapping transcribed regions using genomic tiling arrays. Tiling arrays enable

Gerstein, Mark

372

The Human Microbiome Project: A Community Resource for the Healthy Human Microbiome  

E-Print Network (OSTI)

The Human Microbiome Project (HMP) [1],[2] is a concept that was long in the making. After the Human Genome Project, interest grew in sequencing the other genome" of microbes carried in and on the human body [3],[4]. ...

Gevers, Dirk

373

Computational Approaches Towards Human Genome Annotation  

E-Print Network (OSTI)

Computational Approaches Towards Human Genome Annotation Mark Gerstein Molecular Biophysics of the human genome. My talk will be concerned with topics within this area, in particular annotating pseudogenes (protein fossils) in the genome. I will discuss a comprehensive pseudogene identification pipeline

Singh, Jaswinder Pal

374

Substrate Balances across Colonic Carcinomas in Humans  

Science Journals Connector (OSTI)

...in humans, the balances of energy-yielding substrates and amino...observed. It is concluded that the energy metabolism of human colonic...1926. 6. Warburg, O., Wind, F., and Negelein, E. oeberden...glutamine, not sugar, is the major energy source for cultured HeLa cells...

Eggert Holm; Egbert Hagmller; Ulrich Staedt; Gerwin Schlickeiser; Hans-Joachim Gnther; Hans Leweling; Mehmet Tokus; and Hermann B. Kollmar

1995-03-15T23:59:59.000Z

375

Human Resource Management: Employee Compensation Guide  

E-Print Network (OSTI)

Human Resource Management: Employee Compensation Guide Risk Management *Extension Agricultural Economist, Kansas State University Agricultural Experiment Station and Cooperative Extension Service; and Extension Program Specialist III.... ?Employee Compensation and Job Satisfaction on Dairy Farms in the Northeast.? April 1999. Cornell University, RB99-02. Kansas Department of Human Resources. Kansas Wage Survey, 1996 Edition. Rosenberg, Howard. ?Labor Management Decisions.? University...

Fogleman, Sarah L.; McCorkle, Dean

2009-04-08T23:59:59.000Z

376

West Virginia University Division of Human Resources  

E-Print Network (OSTI)

on the WVU Division of Human Resources Web page hr.wvu.edu. In the event of a conflict between the current posted version and this printed copy, the posted version on the Web page is controlling. Page 1 of 2 of this administrative procedure has been posted on the WVU Division of Human Resources Web page hr.wvu.edu. In the event

Mohaghegh, Shahab

377

West Virginia University Division of Human Resources  

E-Print Network (OSTI)

Division of Human Resources Web page hr.wvu.edu. In the event of a conflict between the current posted version and this printed copy, the posted version on the Web page is controlling. Page 1 of 2 Access been posted on the WVU Division of Human Resources Web page hr.wvu.edu. In the event of a conflict

Mohaghegh, Shahab

378

West Virginia University Division of Human Resources  

E-Print Network (OSTI)

Division of Human Resources Web page hr.wvu.edu. In the event of a conflict between the current posted version and this printed copy, the posted version on the Web page is controlling. Page 1 of 2 Employment been posted on the WVU Division of Human Resources Web page hr.wvu.edu. In the event of a conflict

Mohaghegh, Shahab

379

West Virginia University Division of Human Resources  

E-Print Network (OSTI)

on the WVU Division of Human Resources Web page hr.wvu.edu. In the event of a conflict between the current posted version and this printed copy, the posted version on the Web page is controlling. Page 1 of 2 been posted on the WVU Division of Human Resources Web page hr.wvu.edu. In the event of a conflict

Mohaghegh, Shahab

380

West Virginia University Division of Human Resources  

E-Print Network (OSTI)

on the WVU Division of Human Resources Web page hr.wvu.edu. In the event of a conflict between the current posted version and this printed copy, the posted version on the Web page is controlling. Page 1 of 3 Division of Human Resources Web page hr.wvu.edu. In the event of a conflict between the current posted

Mohaghegh, Shahab

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

College of Architecture, Arts, and Humanities ARCHITECTURE,  

E-Print Network (OSTI)

; Environmental Design and Planning; Historic Preservation; His- tory; Landscape Architecture; Professional Com25 College of Architecture, Arts, and Humanities COLLEGE OF ARCHITECTURE, ARTS, AND HUMANITIES The College of Architecture, Arts, and Humani- ties offers graduate programs in three schools: the School

Stuart, Steven J.

382

The Cognitive Neuroscience of Human Memory  

E-Print Network (OSTI)

The Cognitive Neuroscience of Human Memory Since H.M. Larry R. Squire1,2,3,4 and John T. Wixted4 1 about the organization of memory that inspired decades of experi- mental work. Since H.M., the study of human memory and its disorders has continued to yield new insights and to improve understanding

Squire, Larry R.

383

Electrical Stimulation of the Human Cochlea  

Science Journals Connector (OSTI)

... and Scheiber1, and since confirmed2,3,4, that stimulation of the human cochlea by audio-frequency alternating currents results in a sensation of tone corresponding in pitch to the frequency ... considered to provide confirmation of the movement theory of excitation of the human cochlea by audio-frequency electrical stimulation. ...

C. S. HALLPIKE; H. HARTRIDGE

1937-01-30T23:59:59.000Z

384

Exploring the role of prolactin in psoriasis  

Science Journals Connector (OSTI)

Prolactin (PRL) is well recognised for its role(s) in mammary gland development and function. Moreover, its role in skin biology, including the potent regulation of human hair growth, is becoming clearer. Less...

Ewan A. Langan; Christopher E. M. Griffiths

2012-03-01T23:59:59.000Z

385

History of the DOE Human Genome Program  

Office of Scientific and Technical Information (OSTI)

History of the DOE Human Genome Program History of the DOE Human Genome Program The following history is taken from the U.S. Department of Energy 1991-91 Human Genome Program Report (June 1992). This is an archived item. A brief history of the U.S. Department of Energy (DOE) Human Genome Program will be useful in a discussion of the objectives of the DOE program as well as those of the collaborative U.S. Human Genome Project. The Office of Health and Environmental Research (OHER) of DOE and its predecessor agencies--the Atomic Energy Commission and the Energy Research and Development Administration--have long sponsored research into genetics, both in microbial systems and in mammals, including basic studies on genome structure, replication, damage, and repair and the consequences of genetic

386

Diversity at Fermilab - Human Rights Policy  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Rights Policy Human Rights Policy Fermilab attracts scientists, not only from this country, but from many other nations all over the world. Foreign visitors, laypersons, as well as scientists, come to the laboratory to participate in its work. They represent a wide variety of races, nationalities, cultures and beliefs. It is essential that we provide an environment and maintain an atmosphere in which both staff and visitors can live and work with pride and dignity without regard to such differences as race, religion, sex, or national origin. In any conflict between technical expediency and human rights we will stand on the side of human rights. This is because of our dedication to science. The support of human rights in our laboratory and its environs is inextricably intertwined with our goal of making the Laboratory a center of technical and scientific excellence. The latter is not likely to be achieved without success of the former.

387

ORISE: Human Subjects Protection Resource Protection Book  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Subjects Protection Resource Book Human Subjects Protection Resource Book The Human Subjects Protection Resource Book synthesizes information currently available on the protection of human subjects in research, the continuing application of such information to new areas of endeavor, and ever-changing rules, regulations, and guidance. This resource, to which the Oak Ridge Institute for Science and Education (ORISE) contributed, is for investigators, institutional review boards, research organizations, research subjects and others. The book contains chapters that provide background information on the history and development of federal regulations; chapters that discuss procedural and substantive issues regarding the review and conduct of human subjects research; and chapters that are specific to one type of research

388

Habitat for Humanity | Open Energy Information  

Open Energy Info (EERE)

Habitat for Humanity Habitat for Humanity Jump to: navigation, search Name Habitat for Humanity Place Americus, GA Website http://www.habitat.org/ References NREL Technical Report: Zero Energy Home[1] Fact Sheet: Zero Energy Demonstration Home[2] Information About Partnership with NREL Partnership with NREL Yes Partnership Type Test & Evaluation Partner Partnering Center within NREL Electricity Resources & Building Systems Integration Partnership Year 2005 LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! Habitat for Humanity is a company located in Americus, GA. References ↑ "NREL Technical Report: Zero Energy Home" ↑ "Fact Sheet: Zero Energy Demonstration Home" Retrieved from "http://en.openei.org/w/index.php?title=Habitat_for_Humanity&oldid=38172

389

Effect of Exercise on the Induction of Mammary Carcinogenesis  

Science Journals Connector (OSTI)

...010 0.010 0.100 731 The Energy Expenditure of Rats Bearing...that rats are of comparable corn position if the weight of the...nitro.. Mmir@iiet al. "Energy Expenditure of Tumorous Rats...to assume that the principal energy-producing foodstuffs, i...

Henry J. Thompson; Anne M. Ronan; Karen A. Ritacco; Anthony R. Tagliaferro; and L. David Meeker

1988-05-15T23:59:59.000Z

390

Mammary Gland Development, Reproductive History, and Breast Cancer Risk  

Science Journals Connector (OSTI)

...Development, Reproductive History, and Breast Cancer...Molecular and Cellular Engineering, Stellar-Chance...Molecular and Cellular Engineering [L. A. C., C...Development, Reproductive History, and Breast Cancer...Molecular and Cellular Engineering [L. A. C., C...

Lewis A. Chodosh; Celina M. D'Cruz; Heather Perry Gardner; Seung I. Ha; Sandra T. Marquis; Jayant V. Rajan; Douglas B. Stairs; James Y. Wang; and Man Wang

1999-04-01T23:59:59.000Z

391

Neutron-induced Mammary Neoplasms in the Rat  

Science Journals Connector (OSTI)

...female Sprague-Dawley rat. Other workers have established a linear relationship...female Sprague-Dawley rat. Other workers have established a linear relationship...irradiated several groups of rats at the Oak Ridge Health Physics Reactor to a single...

Howard H. Vogel, Jr. and Robert Zaldvar

1972-05-01T23:59:59.000Z

392

Sequencing the transcriptome of milk production: milk trumps mammary tissue  

E-Print Network (OSTI)

important for milk lipid secretion. J Biol Chem 53. Russellin milk lipid formation and secretion. Trends Endocrinol

2013-01-01T23:59:59.000Z

393

Initial sequencing and analysis of the human genome  

E-Print Network (OSTI)

Initial sequencing and analysis of the human genome International Human Genome Sequencing. ............................................................................................................................................................................................................................................................................ The human genome holds an extraordinary trove of information about human development, physiology, medicine a draft sequence of the human genome. We also present an initial analysis of the data, describing some

Eddy, Sean

394

Underwater Human-Robot Interaction via Biological Motion Identification  

E-Print Network (OSTI)

and track human motion. Our objective is to enable human-robot interaction by allowing a robot to follow the detection and tracking of the human operator using the spatio-temporal signature of human motion cues have been shown to be powerful indicators of human activity and have been used

395

CAMB 630 Topics in Human Genetics and Disease Course Directors  

E-Print Network (OSTI)

on the foundations of the Human Genome Project and parallel efforts in model organisms, research in human genetics in Human Genetics and Disease: I. Genome architecture and instability (Spinner) Chromosome specific variation II. Human genomic variation and disease (Devoto) History and substructure of the human population

Plotkin, Joshua B.

396

Nucleic Acid Content and Nuclear Chromatin Structure of Human Bladder Cell Culture Lines as Studied by Flow Cytofluorometry  

Science Journals Connector (OSTI)

...characterizing tissue culture cell lines, as we have done home,and perhaps in distinguishing benign and malignant epithelial...Sharpless, T., and Darzynkiewicz, z. Urinary Cytology Automation. Preliminary Studies with Acridine Orange Stain and Flow-Through...

Myron R. Melamed; Zbigniew Darzynkiewicz; Frank Traganos; and Thomas K. Sharpless

1977-04-01T23:59:59.000Z

397

Human-Centered Fusion Framework  

SciTech Connect

In recent years the benefits of fusing signatures extracted from large amounts of distributed and/or heterogeneous data sources have been largely documented in various problems ranging from biological protein function prediction to cyberspace monitoring. In spite of significant progress in information fusion research, there is still no formal theoretical framework for defining various types of information fusion systems, defining and analyzing relations among such types, and designing information fusion systems using a formal method approach. Consequently, fusion systems are often poorly understood, are less than optimal, and/or do not suit user needs. To start addressing these issues, we outline a formal humancentered fusion framework for reasoning about fusion strategies. Our approach relies on a new taxonomy for fusion strategies, an alternative definition of information fusion in terms of parameterized paths in signature related spaces, an algorithmic formalization of fusion strategies and a library of numeric and dynamic visual tools measuring the impact as well as the impact behavior of fusion strategies. Using a real case of intelligence analysis we demonstrate that the proposed framework enables end users to rapidly 1) develop and implement alternative fusion strategies, 2) understand the impact of each strategy, 3) compare the various strategies, and 4) perform the above steps without having to know the mathematical foundations of the framework. We also demonstrate that the human impact on a fusion system is critical in the sense that small changes in strategies do not necessarily correspond to small changes in results.

Posse, Christian; White, Amanda M.; Beagley, Nathaniel

2007-05-16T23:59:59.000Z

398

19 - The human resources perspective  

Science Journals Connector (OSTI)

Publisher Summary Security convergence is often associated with the accompanying challenges of ensuring that people and people practices are equal to the task. This chapter describes the human resource challenges from the perspective of an organization, which is about to embark upon security convergence. It is noted that true security convergence of physical and IT security requires a leader, who possesses the appropriate talent, ability, and experience. Also, because only a limited number of organizations have converged their IT and physical security operations, there are still relatively few individuals with hands-on experience of leading security convergence. From an HR perspective, there are a number of specific challenges comprising this new world. No matter what the environment is, there are new threats, new demands, and new business drivers and an imperative to respond in order to survive and prosper, as well as to meet the appropriate legislative or governance challenges. Whether it is a need to meet the dictates of corporate governance, or the commercial imperative to protect proprietary information, or simply the need to maximize internal efficiencies, the challenge persists.

Dave Tyson

2007-01-01T23:59:59.000Z

399

Deformable human body model development  

SciTech Connect

This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). A Deformable Human Body Model (DHBM) capable of simulating a wide variety of deformation interactions between man and his environment has been developed. The model was intended to have applications in automobile safety analysis, soldier survivability studies and assistive technology development for the disabled. To date, we have demonstrated the utility of the DHBM in automobile safety analysis and are currently engaged in discussions with the U.S. military involving two additional applications. More specifically, the DHBM has been incorporated into a Virtual Safety Lab (VSL) for automobile design under contract to General Motors Corporation. Furthermore, we have won $1.8M in funding from the U.S. Army Medical Research and Material Command for development of a noninvasive intracranial pressure measurement system. The proposed research makes use of the detailed head model that is a component of the DHBM; the project duration is three years. In addition, we have been contacted by the Air Force Armstrong Aerospace Medical Research Laboratory concerning possible use of the DHBM in analyzing the loads and injury potential to pilots upon ejection from military aircraft. Current discussions with Armstrong involve possible LANL participation in a comparison between DHBM and the Air Force Articulated Total Body (ATB) model that is the current military standard.

Wray, W.O.; Aida, T.

1998-11-01T23:59:59.000Z

400

Human-computer interface design  

SciTech Connect

Modern military forces assume that computer-based information is reliable, timely, available, usable, and shared. The importance of computer-based information is based on the assumption that {open_quotes}shared situation awareness, coupled with the ability to conduct continuous operations, will allow information age armies to observe, decide, and act faster, more correctly and more precisely than their enemies.{close_quotes} (Sullivan and Dubik 1994). Human-Computer Interface (HCI) design standardization is critical to the realization of the previously stated assumptions. Given that a key factor of a high-performance, high-reliability system is an easy-to-use, effective design of the interface between the hardware, software, and the user, it follows logically that the interface between the computer and the military user is critical to the success of the information-age military. The proliferation of computer technology has resulted in the development of an extensive variety of computer-based systems and the implementation of varying HCI styles on these systems. To accommodate the continued growth in computer-based systems, minimize HCI diversity, and improve system performance and reliability, the U.S. Department of Defense (DoD) is continuing to adopt interface standards for developing computer-based systems.

Bowser, S.E.

1995-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Human Reliability Considerations for Small Modular Reactors  

SciTech Connect

Small modular reactors (SMRs) are a promising approach to meeting future energy needs. Although the electrical output of an individual SMR is relatively small compared to that of typical commercial nuclear plants, they can be grouped to produce as much energy as a utility demands. Furthermore, SMRs can be used for other purposes, such as producing hydrogen and generating process heat. The design characteristics of many SMRs differ from those of current conventional plants and may require a distinct concept of operations. The U.S. Nuclear Regulatory Commission (NRC) conducted research to examine the human factors engineering and the operational aspects of SMRs. The research identified thirty potential human-performance issues that should be considered in the NRC's reviews of SMR designs and in future research activities. The purpose of this report is to illustrate how the issues can support SMR probabilistic risk analyses and their review by identifying potential human failure events for a subset of the issues. As part of addressing the human contribution to plant risk, human reliability analysis practitioners identify and quantify the human failure events that can negatively impact normal or emergency plant operations. The results illustrated here can be generalized to identify additional human failure events for the issues discussed and can be applied to those issues not discussed in this report.

OHara J. M.; Higgins, H.; DAgostino, A.; Erasmia, L.

2012-01-27T23:59:59.000Z

402

Distinct Luminal-Type Mammary Carcinomas Arise from Orthotopic Trp53-Null Mammary Transplantation of Juvenile versus Adult Mice  

Science Journals Connector (OSTI)

...Program, funding from the Department of Energy, Office of Biological and Environmental...1049-56. 2. Rakha EA , El-Sayed ME, Green AR, Lee AH, Robertson JF Ellis IO.Prognostic...Elsheikh SE, Aleskandarany MA, Habashi HO, Green AR, Powe DG, et alTriple-negative breast...

David H. Nguyen; Haoxu Ouyang; Jian-Hua Mao; Lynn Hlatky; and Mary Helen Barcellos-Hoff

2014-12-01T23:59:59.000Z

403

Phosphorus Metabolism in Resting and Pregnancy-stimulated Mammary Glands and in Spontaneous Mammary Carcinomas of Mice  

Science Journals Connector (OSTI)

...basis of the findings of other workers, it was concluded that this increased...experiments was furnished by the Oak Ridge National Laboratory, Oak Ridge, Tenn. 4 These values...suggested by Schulman and his co-workers (17, 18), has been used to...

S. Albert; R. M. Johnson; and Marjorie S. Cohan

1951-10-01T23:59:59.000Z

404

Phosphorus Metabolism in Resting and Pregnancy-stimulated Mammary Glands and in Spontaneous Mammary Carcinomas of Mice  

Science Journals Connector (OSTI)

...April 16, 1950. S. Albert...48 hours after injection...of other workers, it was...48 hours after injection...furnished by the Oak Ridge National Laboratory, Oak Ridge, Tenn...least 10 days after delivery...April 16, 1950. 1 For the...

S. Albert; R. M. Johnson; and Marjorie S. Cohan

1951-10-01T23:59:59.000Z

405

2-Deoxyglucose as an Energy Restriction Mimetic Agent: Effects on Mammary Carcinogenesis and on Mammary Tumor Cell Growth In vitro  

Science Journals Connector (OSTI)

...Thompson HJ. Effect of energy restriction on cell cycle...breast cancer research. New York: Kluwer Academic/Plenum...Thompson HJ. Mechanisms of energy restriction: effects of...nonparametric statistics. New York: John Wiley Sons; 1980...

Zongjian Zhu; Weiqin Jiang; John N. McGinley; and Henry J. Thompson

2005-08-01T23:59:59.000Z

406

2-Deoxyglucose as an Energy Restriction Mimetic Agent: Effects on Mammary Carcinogenesis and on Mammary Tumor Cell Growth In vitro  

Science Journals Connector (OSTI)

...and Prevention 2-Deoxyglucose as an Energy Restriction Mimetic Agent: Effects on...University, Fort Collins, Colorado Dietary energy restriction (DER) is a potent inhibitor...Consequently, interest exists in identifying energy restriction mimetic agents (ERMAs...

Zongjian Zhu; Weiqin Jiang; John N. McGinley; Henry J. Thompson

2005-08-01T23:59:59.000Z

407

Neutron scattering study of human serum low density lipoprotein  

Science Journals Connector (OSTI)

Neutron scattering study of human serum low density...human serum have been determined by neutron scattering. From measurements in various H2O...protein emerging from the lipid core. Neutron scattering study of human serum low density...

H B Stuhrmann; A Tardieu; L Mateu; C Sardet; V Luzzati; L Aggerbeck; A M Scanu

1975-01-01T23:59:59.000Z

408

Human retroviruses and AIDS 1997  

SciTech Connect

This compendium is the result of an effort to compile, organize, and rapidly publish as much relevant molecular data concerning the human immunodeficiency viruses (HIV) and related retroviruses as possible. The scope of the compendium and database is best summarized by the four parts that it comprises: (1) Nucleic Acid Alignments, (2) Amino Acid Alignments, (3) Reviews and Analyses, and (4) Related Sequences. Information within all the parts is updated throughout the year on the Web site, http://hiv-web.lanl.gov. This year we are not including floppy diskettes as the entire compendium is available both at our Web site and at our ftp site. If you need floppy diskettes please contact either Bette Korber (btk@t10.lanl.gov) or Kersti Rock (karm@t10.lanl.gov) by email or fax ((505) 665-4453). While this publication could take the form of a review or sequence monograph, it is not so conceived. Instead, the literature from which the database is derived has simply been summarized and some elementary computational analyses have been performed upon the data. Interpretation and commentary have been avoided insofar as possible so that the reader can form his or her own judgments concerning the complex information. The exception to this are reviews submitted by experts in areas deemed of particular and basic importance to research involving AIDS viral sequence information. These are included in Part III, and are contributed by scientists with particular expertise in the area of interest. In addition to the general descriptions below of the parts of the compendium, the user should read the individual introductions for each part.

Korber, B.; Foley, B.; Leitner, T. [eds.] [and others] [eds.; and others

1997-12-01T23:59:59.000Z

409

Applying lessons learned to enhance human performance and reduce human error for ISS operations  

SciTech Connect

A major component of reliability, safety, and mission success for space missions is ensuring that the humans involved (flight crew, ground crew, mission control, etc.) perform their tasks and functions as required. This includes compliance with training and procedures during normal conditions, and successful compensation when malfunctions or unexpected conditions occur. A very significant issue that affects human performance in space flight is human error. Human errors can invalidate carefully designed equipment and procedures. If certain errors combine with equipment failures or design flaws, mission failure or loss of life can occur. The control of human error during operation of the International Space Station (ISS) will be critical to the overall success of the program. As experience from Mir operations has shown, human performance plays a vital role in the success or failure of long duration space missions. The Department of Energy`s Idaho National Engineering and Environmental Laboratory (INEEL) is developed a systematic approach to enhance human performance and reduce human errors for ISS operations. This approach is based on the systematic identification and evaluation of lessons learned from past space missions such as Mir to enhance the design and operation of ISS. This paper describes previous INEEL research on human error sponsored by NASA and how it can be applied to enhance human reliability for ISS.

Nelson, W.R.

1998-09-01T23:59:59.000Z

410

Human-robot cross-training: Computational formulation, modeling and evaluation of a human team training strategy  

E-Print Network (OSTI)

We design and evaluate human-robot cross-training, a strategy widely used and validated for effective human team training. Cross-training is an interactive planning method in which a human and a robot iteratively switch ...

Nikolaidis, Stefanos

411

Spatial Spectra of Human ECG 1 Freeman et al. Spatial spectral analysis of human electrocorticograms including the  

E-Print Network (OSTI)

Spatial Spectra of Human ECG 1 Freeman et al. Spatial spectral analysis of human Spectra of Human ECG 2 Freeman et al. (AM) of a broad spectrum gamma oscillation having a similar

Freeman, Walter J.

412

Inference of Human Motion using Low-cost Sensors  

E-Print Network (OSTI)

human motions with feasible cost (manufacture cost, power,power source. For these reasons, in this chapter we formulated a system, which can track human motion

Chien, Chieh

2013-01-01T23:59:59.000Z

413

PIA - Human Resources System/Payroll System | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

System PIA - Human Resources SystemPayroll System More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - INL SECURITY INFORMATION MANAGEMENT SYSTEM...

414

PIA - Savannah River Nuclear Solutions (SRNS) Human Resource...  

Office of Environmental Management (EM)

Solutions (SRNS) Human Resource Management System (HRMS) PIA - Savannah River Nuclear Solutions (SRNS) Human Resource Management System (HRMS) PIA - Savannah River Nuclear...

415

Lina Jansen Human Eye Movements in Three Dimensional  

E-Print Network (OSTI)

Lina Jansen Human Eye Movements in Three Dimensional Natural Scenes PICS Publications of Cognitive Science #12;Bachelor's Thesis Human eye movements in three dimensional natural scenes Lina Jansen

Kallenrode, May-Britt

416

Human Health Science Building Geothermal Heat Pumps | Department...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Human Health Science Building Geothermal Heat Pumps Human Health Science Building Geothermal Heat Pumps Project objectives: Construct a ground sourced heat pump, heating,...

417

Revising California Policies on Human Trafficking Will Help Protect Victims  

E-Print Network (OSTI)

ON HUMAN TRAFFICKING WILL HELP PROTECT VICTIMS BY LAURAON HUMAN TRAFFICKING WILL HELP PROTECT VICTIMS Humanhuman trafficking laws could help shift the paradigm and

Carter, Laura

2013-01-01T23:59:59.000Z

418

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic...

419

Antibody library project could unlock mysteries of human gene...  

NLE Websites -- All DOE Office Websites (Extended Search)

Mysteries of human gene function Antibody library project could unlock mysteries of human gene function By looking at antibodies, researchers can identify where, in a cell, genes...

420

Factors Influencing Human Postures 3.1 Introduction  

E-Print Network (OSTI)

by the human body are very difficult to simulate since the human body has so many interrelated muscles the CNS system activates muscles. CNS processes its sensory inp

Rodríguez, Inmaculada

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Medical Sequencing at the extremes of Human Body Mass  

E-Print Network (OSTI)

Medical Sequencing at the Extremes of Human Body Mass Nadavcandidate genes and the extremes of human body mass.especially in the population extremes of a given phenotype

2006-01-01T23:59:59.000Z

422

Ecosystem services and human culture Judith Hanna  

E-Print Network (OSTI)

, pollination Cultural: Aesthetic, spiritual, educational, recreational Security: personal safety, secureEcosystem services and human culture Judith Hanna (Social science principal specialist) Judith, happiness, social/community acceptance, recognition, etc) #12;Some problems: · ***What is `culture

423

Galaxies, Human Eyes and Artificial Neural Networks  

E-Print Network (OSTI)

Quantitative morphological classification of galaxies is important for understanding the origin of type frequency and correlations with environment. But galaxy morphological classification is still mainly done visually by dedicated individuals, in the spirit of Hubble's original scheme, and its modifications. The rapid increase in data on galaxy images at low and high redshift calls for re-examination of the classification schemes and for new automatic methods. Here we show results from the first systematic comparison of the dispersion among human experts classifying a uniformly selected sample of over 800 digitised galaxy images. These galaxy images were then classified by six of the authors independently. The human classifications are compared with each other, and with an automatic classification by Artificial Neural Networks (ANN). It is shown that the ANNs can replicate the classification by a human expert to the same degree of agreement as that between two human experts.

O. Lahav; A. Naim; R. J. Buta; H. G. Corwin; G. de Vaucouleurs; A. Dressler; J. P. Huchra; S. van den Bergh; S. Raychaudhury; L. Sodre Jr.; M. C. Storrie-Lombardi

1994-12-08T23:59:59.000Z

424

HST.071 Human Reproductive Biology, Fall 2002  

E-Print Network (OSTI)

Lectures and clinical case discussions designed to provide the student with a clear understanding of the physiology, endocrinology, and pathology of human reproduction. Emphasis is on the role of technology in reproductive ...

Klapholz, Henry

425

Case Study: Southeast Volusia Habitat for Humanity  

Office of Energy Efficiency and Renewable Energy (EERE)

In August 2013, Southeast Volusia County Habitat for Humanity (VolusiaHabitat) completed its first U.S. Department of Energy (DOE) Zero EnergyReady Home in Edgewater, on the Atlantic coast of...

426

INDIVIDUAL DISCIPLINES: HUMAN RESOURCES DIVISION MARKETING  

E-Print Network (OSTI)

INDIVIDUAL DISCIPLINES: HUMAN RESOURCES DIVISION MARKETING AND RECRUITMENT CAMPAIGN STAFF .:|:. Client: Y. Mankin, Computing Sciences #12;DESIGN MAIN MENU 1 2 344 4 5WEBSITES Joint BioEnergy Institute

427

Reconstructing human evolution: Achievements, challenges, and opportunities  

Science Journals Connector (OSTI)

...occipital bone. Mandibular and dental features include a retromolar...incidences of some nonmetrical dental traits, and thinner...F ( 2000 ) Using diagnostic radiology in human evolutionary studies...Nondestructive imaging of hominoid dental microstructure using phase contrast...

Bernard Wood

2010-01-01T23:59:59.000Z

428

Human Capital: Education, Innovation and Health  

Science Journals Connector (OSTI)

Table5.15...shows that, despite the gradual increase in educational expenditure (both in absolute terms and as a ... in the size of the investment in human capital production. Finally, a substantial increase in....

Prof. Panagiotis Petrakis

2012-01-01T23:59:59.000Z

429

1 Calibration against independent human travel datasets  

E-Print Network (OSTI)

1 Calibration against independent human travel datasets 1.1 Calibration against United States at www.bts.gov. Although the BTS dataset is large, the movements were histogrammed 1 #12;with a low

Shull, Kenneth R.

430

The National Plan for Aviation Human Factors  

Science Journals Connector (OSTI)

Effective verification and validation of complex and integrated human-machine systems depends on the selection of appropriate performance measures and on the adequacy of the measurement tools and procedures us...

Joseph Pitts; Phyllis Kayten

1993-01-01T23:59:59.000Z

431

West Nile Encephalitis in Humans and Horses  

E-Print Network (OSTI)

Humans and horses are infected with West Nile Encephalitis after being bitten by mosquitoes that transmit the virus. Migratory birds are thought to be responsible for the introduction of the virus into new areas. This publication explains...

Lawhorn, D. Bruce

2000-08-25T23:59:59.000Z

432

Fluid coordination of human-robot teams  

E-Print Network (OSTI)

I envision a future where collaboration between humans and robots will be indispensable to our work in numerous domains, ranging from surgery to space exploration. The success of these systems will depend in part on the ...

Shah, Julie A

2011-01-01T23:59:59.000Z

433

Director, Human Resources Shared Service Center  

Energy.gov (U.S. Department of Energy (DOE))

The Department of Energy is looking for an energetic, innovative executive who will enjoy working in a dynamic and mission driven organization as the Director, Human Resources Shared Service Center...

434

Data-driven human body morphing  

E-Print Network (OSTI)

This thesis presents an efficient and biologically informed 3D human body morphing technique through data-driven alteration of standardized 3D models. The anthropometric data is derived from a large empirical database and processed using principal...

Zhang, Xiao

2005-11-01T23:59:59.000Z

435

Energy Source for the Human Demand  

Science Journals Connector (OSTI)

Lack of water and food, extinction of plants and animals, human catastrophe and other serious environmental crises are occurring as a result of the large increase in the population of mankind. Yet, the Asian c...

Sadao Hattori

1997-01-01T23:59:59.000Z

436

Human Capital Accountability Program--Withdrawn  

Directives, Delegations, and Requirements

Withdrawn 3-26-14. The purpose of maintaining and updating this directive is to (1) Ensure compliance with applicable laws, regulations, and other directives. (2) Reduce the risk of DOE losing any of its personnel authorities. (3) Incorporate functional accountability to ensure that Human Resource Directors' position descriptions and classifications are appropriate, selections result in quality leadership with skills needed, and performance plans and evaluations are consistent with Department and Administration human resources priorities and audit findings.

2012-11-15T23:59:59.000Z

437

Depth-resolved monitoring of diffusion of hyperosmotic agents in normal and malignant human esophagus tissues using optical coherence tomography in-vitro  

SciTech Connect

Depth-resolved monitoring with differentiation and quantification of glucose diffusion in healthy and abnormal esophagus tissues has been studied in vitro. Experiments have been performed using human normal esophagus and esophageal squamous cell carcinoma (ESCC) tissues by the optical coherence tomography (OCT). The images have been continuously acquired for 120 min in the experiments, and the depth-resolved and average permeability coefficients of the 40 % glucose solution have been calculated by the OCT amplitude (OCTA) method. We demonstrate the capability of the OCT technique for depth-resolved monitoring, differentiation, and quantifying of glucose diffusion in normal esophagus and ESCC tissues. It is found that the permeability coefficients of the 40 % glucose solution are not uniform throughout the normal esophagus and ESCC tissues and increase from (3.30 {+-} 0.09) Multiplication-Sign 10{sup -6} and (1.57 {+-} 0.05) Multiplication-Sign 10{sup -5} cm s{sup -1} at the mucous membrane of normal esophagus and ESCC tissues to (1.82 {+-} 0.04) Multiplication-Sign 10{sup -5} and (3.53 {+-} 0.09) Multiplication-Sign 10{sup -5} cm s{sup -1} at the submucous layer approximately 742 {mu}m away from the epithelial surface of normal esophagus and ESCC tissues, respectively. (optical coherence tomography)

Zhao Qingliang; Guo Zhouyi; Wei Huajiang; Yang Hongqin; Xie Shusen

2011-10-31T23:59:59.000Z

438

Sprouty-4 Inhibits Transformed Cell Growth, Migration and Invasion, and Epithelial-Mesenchymal Transition, and Is Regulated by Wnt7A through PPAR? in NonSmall Cell Lung Cancer  

Science Journals Connector (OSTI)

...West J, Franklin W, et al. Altered HOX and WNT7A expression in human lung cancer. Proc Natl Acad Sci U S A 2000;97:12776-81. 55 Kirikoshi H , Katoh M. Expression of WNT7A in human normal tissues and cancer, and regulation of WNT7A and WNT7B...

Meredith A. Tennis; Michelle M. Van Scoyk; Scott V. Freeman; Katherine M. Vandervest; Raphael A. Nemenoff; Robert A. Winn

2010-06-01T23:59:59.000Z

439

MiR-145 regulates PAK4 via the MAPK pathway and exhibits an antitumor effect in human colon cells  

SciTech Connect

Highlights: Black-Right-Pointing-Pointer MiR-145 targets a putative binding site in the 3 Prime UTR of PAK4. Black-Right-Pointing-Pointer MiR-145 played an important role in inhibiting cell growth by directly targeting PAK4. Black-Right-Pointing-Pointer MiR-145 may function as tumor suppressors. -- Abstract: MicroRNAs (miRNAs) are regulators of numerous cellular events; accumulating evidence indicates that miRNAs play a key role in a wide range of biological functions, such as cellular proliferation, differentiation, and apoptosis in cancer. Down-regulated expression of miR-145 has been reported in colon cancer tissues and cell lines. The molecular mechanisms underlying miR-145 and the regulation of colon carcinogenesis remain unclear. In this study, we investigated the levels of miR-145 in human colon cancer cells using qRT-PCR and found markedly decreased levels compared to normal epithelial cells. We identified PAK4 as a novel target of miR-145 using informatics screening. Additionally, we demonstrated that miR-145 targets a putative binding site in the 3 Prime UTR of PAK4 and that its abundance is inversely associated with miR-145 expression in colon cancer cells; we confirmed this relationship using the luciferase reporter assay. Furthermore, restoration of miR-145 by mimics in SW620 cells significantly attenuated cell growth in vitro, in accordance with the inhibitory effects induced by siRNA mediated knockdown of PAK4. Taken together, these findings demonstrate that miR-145 downregulates P-ERK expression by targeting PAK4 and leads to inhibition of tumor growth.

Wang, Zhigang [Department of General Surgery, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai (China)] [Department of General Surgery, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai (China); Zhang, Xiaoping [Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine (China)] [Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine (China); Yang, Zhili; Du, Hangxiang; Wu, Zhenqian; Gong, Jianfeng; Yan, Jun [Department of General Surgery, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai (China)] [Department of General Surgery, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai (China); Zheng, Qi, E-mail: zhengqi1957@yahoo.com.cn [Department of General Surgery, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai (China)] [Department of General Surgery, Shanghai Jiaotong University Affiliated 6th People's Hospital, Shanghai (China)

2012-10-26T23:59:59.000Z

440

16.459 Humans & Automation Seminar February 6, 2002  

E-Print Network (OSTI)

simulations Automated bank teller system design ACT-R Modeling problem solving and learning Various problem ­ To provide rapid prototype simulator to examine human operator performance as a function of human interface16.459 Humans & Automation Seminar February 6, 2002 Miwa Hayashi #12;!Human-Machine System Design

Goldwasser, Shafi

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
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441

Assembly and Analysis of Extended Human Genomic Contig Regions  

E-Print Network (OSTI)

@ibc.wustl.edu; states@ibc.wustl.edu Abstract The Human Genome Project (HGP) has led to the deposit of human genomic The U.S. Human Genome Project, coordinated by the United States Department of Energy (DOEAssembly and Analysis of Extended Human Genomic Contig Regions Eric C. Rouchka and David J. States

Rouchka, Eric

442

CAMB 630 Topics in Human Genetics and Disease Course Directors  

E-Print Network (OSTI)

on the foundations of the Human Genome Project and parallel efforts in model organisms, research in human genetics in Human Genetics and Disease: I. Genome architecture and instability (Spinner) Chromosome specific of Mendelian disease Developmental pathways and genetic disease III. Human genomic variation and disease

Plotkin, Joshua B.

443

MEETING REPORT Open Access The human proteome a scientific opportunity  

E-Print Network (OSTI)

enhance overall biomedical research and future healthcare. The Human Genome Project and its many follow Reaction Monitoring (SRM) Atlas, and the Human Proteome Project organized by the Human ProteomeMEETING REPORT Open Access The human proteome ­ a scientific opportunity for transforming

444

Human Diversity: Our Genes Tell Where we Live  

E-Print Network (OSTI)

of Human Polymorphism (CEPH) in the framework of the Human Genome Diversity Project initiated by LucaHuman Diversity: Our Genes Tell Where we Live Dispatch Laurent Excoffier A detailed genetic analysis of more than a thousand human subjects clusters them into five groups corresponding to major

Rosenberg, Noah

445

CS 4317 Human-Computer Interaction Course Number: CS4317  

E-Print Network (OSTI)

interaction. Theory of human-computer interaction. Development methods for interfaces such as user1 CS 4317 Human-Computer Interaction Course Number: CS4317 Course Title: Human-Computer Interaction Course Instructors Nigel Ward Course Description: CS4317: Models and methods of human-computer

Ward, Karen

446

r Human Brain Mapping 00:000000 (2011) r Brain Regions Involved in Human Movement  

E-Print Network (OSTI)

, however, to extract the key circuits involved in human motion perception across the variety of paradigms words: FMRI; human motion; action observation; superior temporal sulcus; premotor cortex; inferior (INM-2), Research Center Ju¨lich r r Abstract: Face, hands, and body movements are powerful signals

Williamson, John

447

Human Resources hs_pro08 Page 1 of 12 Human Resources: Health, Safety & Wellbeing  

E-Print Network (OSTI)

to Worksafe NZ , any restricted work as defined in regulation 2 and 26 of The Health and Safety in EmploymentHuman Resources ­ hs_pro08 Page 1 of 12 Human Resources: Health, Safety & Wellbeing Protocol & Safety Manager Contact: Health & Safety Team Table of Contents Introduction

Hickman, Mark

448

Bachelor of Science in Human Services Department of Counseling and Human Services  

E-Print Network (OSTI)

Bachelor of Science in Human Services Department of Counseling and Human Services Darden College: ________________________________________________________________________ Site: On-campus/Hampton Roads OR TTN site: _____________________________________(Select one) GENERAL, or THEA 241A ___________________ 3_____ Interpreting the Past ­ 3 hours HIST 100H, 101H, 102H, 103H, 104H

449

Bachelor of Science in Human Services Department of Counseling and Human Services  

E-Print Network (OSTI)

Bachelor of Science in Human Services Department of Counseling and Human Services Darden College: ________________________________________________________________________ Site: On-campus OR Online: _____________________________________(Select one) GENERAL EDUCATION AND PRE_____ Interpreting the Past ­ 3 hours HIST 100H, 101H, 102H, 103H, 104H or 105H _________________ 3_____ Literature

450

Impact of the [delta]F508 Mutation in First Nucleotide-binding Domain of Human Cystic Fibrosis Transmembrane Conductance Regulator on Domain Folding and Structure  

SciTech Connect

Cystic fibrosis is caused by defects in the cystic fibrosis transmembrane conductance regulator (CFTR), commonly the deletion of residue Phe-508 (DeltaF508) in the first nucleotide-binding domain (NBD1), which results in a severe reduction in the population of functional channels at the epithelial cell surface. Previous studies employing incomplete NBD1 domains have attributed this to aberrant folding of DeltaF508 NBD1. We report structural and biophysical studies on complete human NBD1 domains, which fail to demonstrate significant changes of in vitro stability or folding kinetics in the presence or absence of the DeltaF508 mutation. Crystal structures show minimal changes in protein conformation but substantial changes in local surface topography at the site of the mutation, which is located in the region of NBD1 believed to interact with the first membrane spanning domain of CFTR. These results raise the possibility that the primary effect of DeltaF508 is a disruption of proper interdomain interactions at this site in CFTR rather than interference with the folding of NBD1. Interestingly, increases in the stability of NBD1 constructs are observed upon introduction of second-site mutations that suppress the trafficking defect caused by the DeltaF508 mutation, suggesting that these suppressors might function indirectly by improving the folding efficiency of NBD1 in the context of the full-length protein. The human NBD1 structures also solidify the understanding of CFTR regulation by showing that its two protein segments that can be phosphorylated both adopt multiple conformations that modulate access to the ATPase active site and functional interdomain interfaces.

Lewis, Hal A.; Zhao, Xun; Wang, Chi; Sauder, J. Michael; Rooney, Isabelle; Noland, Brian W.; Lorimer, Don; Kearins, Margaret C.; Conners, Kris; Condon, Brad; Maloney, Peter C.; Guggino, William B.; Hunt, John F.; Emtage, Spencer (SG); (Columbia); (JHU)

2010-07-19T23:59:59.000Z

451

Three Human Cell Types Respond to Multi-Walled Carbon Nanotubes and Titanium Dioxide Nanobelts with Cell-Specific Transcriptomic and Proteomic Expression Patterns.  

SciTech Connect

The growing use of engineered nanoparticles (NPs) in commercial and medical applications raises the urgent need for tools that can predict NP toxicity. Global transcriptome and proteome analyses were conducted on three human cell types, exposed to two high aspect ratio NP types, to identify patterns of expression that might indicate high versus low NP toxicity. Three cell types representing the most common routes of human exposure to NPs, including macrophage-like (THP-1), small airway epithelial and intestinal (Caco-2/HT29-MTX) cells, were exposed to TiO2 nanobelts (TiO2-NB; high toxicity) and multi-walled carbon nanotubes (MWCNT; low toxicity) at low (10 g/mL) and high (100 g/mL) concentrations for 1 and 24 h. Unique patterns of gene and protein expressions were identified for each cell type, with no differentially expressed (p < 0.05, 1.5-fold change) genes or proteins overlapping across all three cell types. While unique to each cell type, the early response was primarily independent of NP type, showing similar expression patterns in response to both TiO2-NB and MWCNT. The early response might, therefore, indicate a general response to insult. In contrast, the 24 h response was unique to each NP type. The most significantly (p < 0.05) enriched biological processes in THP-1 cells indicated TiO2-NB regulation of pathways associated with inflammation, apoptosis, cell cycle arrest, DNA replication stress and genomic instability, while MWCNT-regulated pathways indicated increased cell proliferation, DNA repair and anti-apoptosis. These two distinct sets of biological pathways might, therefore, underlie cellular responses to high and low NP toxicity, respectively.

Tilton, Susan C.; Karin, Norman J.; Tolic, Ana; Xie, Yumei; Lai, Xianyin; Hamilton, Raymond F.; Waters, Katrina M.; Holian, Andrij; Witzmann, Frank A.; Orr, Galya

2014-08-01T23:59:59.000Z

452

Human-mouse comparative genomics: successes and failures to reveal functional regions of the human genome  

SciTech Connect

Deciphering the genetic code embedded within the human genome remains a significant challenge despite the human genome consortium's recent success at defining its linear sequence (Lander et al. 2001; Venter et al. 2001). While useful strategies exist to identify a large percentage of protein encoding regions, efforts to accurately define functional sequences in the remaining {approx}97 percent of the genome lag. Our primary interest has been to utilize the evolutionary relationship and the universal nature of genomic sequence information in vertebrates to reveal functional elements in the human genome. This has been achieved through the combined use of vertebrate comparative genomics to pinpoint highly conserved sequences as candidates for biological activity and transgenic mouse studies to address the functionality of defined human DNA fragments. Accordingly, we describe strategies and insights into functional sequences in the human genome through the use of comparative genomics coupled wit h functional studies in the mouse.

Pennacchio, Len A.; Baroukh, Nadine; Rubin, Edward M.

2003-05-15T23:59:59.000Z

453

Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla  

Science Journals Connector (OSTI)

...in mucus and/or the apical surfaces of gut epithelial cells...enable it to degrade certain xylans [GH family 10 and Carbo-hydrate...processing enzymes) n 4 mice/treatment group. (G) Heat map of...host expression data from all treatment groups: germ-free, B...

Michael A. Mahowald; Federico E. Rey; Henning Seedorf; Peter J. Turnbaugh; Robert S. Fulton; Aye Wollam; Neha Shah; Chunyan Wang; Vincent Magrini; Richard K. Wilson; Brandi L. Cantarel; Pedro M. Coutinho; Bernard Henrissat; Lara W. Crock; Alison Russell; Nathan C. Verberkmoes; Robert L. Hettich; Jeffrey I. Gordon

2009-01-01T23:59:59.000Z

454

Human Resources Reports | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Human Resources Reports Human Resources Reports Human Resources Reports August 21, 2013 Inspection Report: INS-L-13-06 Allegations of Irregular Hiring Practices and Preferential Treatment in the Loan Programs Office July 16, 2013 MANAGEMENT ALERT: DOE/IG-0891 Allegations Regarding Prohibited Personnel Practices at the Bonneville Power Administration June 6, 2013 Inspection Report: DOE/IG-0888 Alleged Nepotism and Wasteful Spending in the Office of Energy Efficiency and Renewable Energy March 22, 2013 Inspection Report: DOE-IG-0882 Approval of Contractor Executive Salaries by Department of Energy Personnel June 22, 2012 Inspection Report: INS-L-12-04 Alleged Procurement and Hiring Practice Irregularities within the Office of Policy and International Affairs June 18, 2012 Audit Report: IG-0867

455

Link Climate Change and Human Health  

NLE Websites -- All DOE Office Websites (Extended Search)

Make Our Science Accessible Make Our Science Accessible Link Climate Change & Health Provide Data and Tools Coordinate Internationally Link Climate Change and Human Health Print E-mail Health News Check out the latest climate change and human health news and announcements in our Health News Feed. Climate change poses unique challenges to human health. Unlike health threats caused by a particular toxin or disease pathogen, there are many ways that climate change can lead to potentially harmful health effects. Direct health impacts may include increased illnesses and deaths from extreme heat events, injuries and deaths from extreme weather events, and respiratory illnesses due to changes in air quality Indirect health impacts include illnesses and deaths that may arise from

456

Report: Human Capital Discussion and Observations  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Human Capital Discussion, Human Capital Discussion, Observations, and Recommendations August 24, 2006 Submitted by: Mr. A. James Barnes and Mr. Dennis Ferrigno Background: During the March 23-24, 2006 EMAB Public Meeting, Assistant Secretary for Environmental Management (EM-1), James Rispoli, asked the EMAB members to pursue a review of EM Human Capital issues. Although the National Academy of Public Administration (NAPA) is also conducting a review of this topic - the results of which will be available in October 2007 - Mr. Rispoli instructed EMAB to identify areas that need improvement and make recommendations to begin bettering the program now. EMAB focused specifically on the areas of: Morale/Workplace Census Planning/Accountability Training/Certification

457

Rocky Mountain Humane Investing | Open Energy Information  

Open Energy Info (EERE)

Humane Investing Humane Investing Jump to: navigation, search Name Rocky Mountain Humane Investing Place Allenspark, Colorado Zip 80510 Product Allenspark-based investment management firm prioritising Socially Responsible Investing (SRI). Coordinates 40.19472°, -105.525719° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.19472,"lon":-105.525719,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

458

PRIVACY IMPACT ASSESSMENT: Human Resources Personal Information  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Human Human Resources - Personal Information Change Request PIA Template Version 3 - May, 2009 Department of Energy Privacy Impact Assessment (PIA) Guidance is provided in the template. See DOE Order 206.1, Department of Energy Privacy Program, Appendix A, Privacy Impact Assessments, for requirements and additional guidance for conducting a PIA: http://www.directives.doe.gov/pdfs/doe/doetext/neword/206/o2061.pdf Please complete electronically: no hand-written submissions will be accepted. This template may not be modified. MODULE 1- PRIVACY NEEDS ASSESSMENT Date Departmental Element & Site Idaho National Engineering Laboratory Engineering Research Office Building (EROB) Name of Information Human Resources - Personal Information Change Request System or IT Project Business Enclave Exhibit Project UID 106800 NewPIA ~ Update D N T 'tl I Contact Information arne,

459

Dishwasher: 1; Human: 0 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Dishwasher: 1; Human: 0 Dishwasher: 1; Human: 0 Dishwasher: 1; Human: 0 December 21, 2009 - 10:58am Addthis Amy Foster Parish My dishwasher and I have been locked in mortal combat for almost a month now, ever since it decided to quit working at nearly the same moment I decided to start washing the Thanksgiving dinner dishes. Over the past week it has started to look as if the dishwasher may have won the battle. And so, while I've been contemplating washing all those Christmas dishes by hand this year, I've also been shopping for a new energy-efficient dishwasher to replace my old one. As someone who's planning on buying a new appliance in the near future, I've been really excited about the possibility of taking advantage of new state rebates for the purchase of ENERGY STAR® qualified appliances.

460

Justice and the Human Genome Project  

Science Journals Connector (OSTI)

...Justice and the Human Genome Project is a concise book, easily read on a late night or weekend. It will be of interest to all medical practitioners who care for patients who require genetic testing. In a broader sense, the issues of social equity and individual liberties are relevant to everyone. For... Justice and the Human Genome Project is a collection of essays based on presentations at a conference with the same title sponsored by the Department of Energy and the University of Illinois at Chicago in November 1991. The Ethical, Legal, and Social ...

Lee G.

1995-02-23T23:59:59.000Z

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Human errors and structural failure probability  

Science Journals Connector (OSTI)

Predicting the influence of human errors on structural failure probability is the topic of this paper. There are two principal reasons for needing this information. First, if errors are present after the design of a structure is completed, as is generally the case, this will provide the engineer with a measure of what effect such errors will have on the structural safety. Second, this information is directly useful in the optimisation of quality assurance expenditures, which can effectively be used for controlling the probability of structural failure due to errors. Simplified probabilistic models are developed to integrate human errors into structural risk assessment. Numerical examples illustrate the sensitivity of structural safety to errors.

Dan M. Frangopol

1988-01-01T23:59:59.000Z

462

Traffic culture human factors & traffic safety  

E-Print Network (OSTI)

Traffic culture human factors & traffic safety by Dr.-Ing. Haraldur Sigþórsson and Dr.-Ing. Stefán) Culture, traffic culture and traffic safety culture are interrelated Culture www.hr.is 3 Traffic Culture Traffic safety culture What is culture? · A culture is a collection of behavioral patterns that are found

Karlsson, Brynjar

463

Sverdlovsk revisited: Modeling human inhalation anthrax  

Science Journals Connector (OSTI)

...mentioned above. Models A1, A2, and D predict 44, 247...difficult during flu season, for...second day, with models A1, A2 and D predicting...the range of models that accurately predict the effects...epidemiology Disease Outbreaks Humans Inhalation...

Dean A. Wilkening

2006-01-01T23:59:59.000Z

464

TEMPORARY AGENCY APPOINTMENTS HUMAN RESOURCES GUIDELINE  

E-Print Network (OSTI)

submit the Request for Temporary Support form to Workforce Planning available on the Human Resources web or performance issues should be reported to Workforce Planning. Workforce Planning will contact the temporary of the Request for Temporary Support, Workforce Planning will determine that the services of a temporary agency

Su, Xiao

465

Human embryonic stem cells for brain repair?  

Science Journals Connector (OSTI)

...repair compiled by Siddharthan Chandran, Maeve Caldwell and Nick Allen Human embryonic stem cells for brain repair? Su-Chun...stromal cell co-culture system. This type of technique has merits in its simplicity and the differentiated progenies appear to...

2008-01-01T23:59:59.000Z

466

Division of Human Resources University Grievance Procedures  

E-Print Network (OSTI)

Division of Human Resources University Grievance Procedures Employee Relations/ USF System Grievance Procedure Questions: (813) 974-2970 Rev. 12/2012 This procedure applies to Administration, Staff in this procedure are expressed in calendar days. If a deadline falls on a Saturday, Sunday or holiday, an action

Meyers, Steven D.

467

Philosophy Honours (& BA Humanities and Social Science)  

E-Print Network (OSTI)

Philosophy Honours Handbook (& BA Humanities and Social Science) 2012/2013 Philosophy School of Philosophy, Psychology and Language Sciences University of Edinburgh #12;1 Philosophy Honours Handbook (& BA.......................................... 13 #12;2 1. Resources for Philosophy A complete list of the full-time academic staff in Philosophy

Edinburgh, University of

468

Understanding complexity in the human brain  

E-Print Network (OSTI)

Understanding complexity in the human brain Danielle S. Bassett1 and Michael S. Gazzaniga2 1 the ultimate aim of neuroscientific enquiry is to gain an understanding of the brain and how its work- ings of mind­brain mechanisms if the cumulative findings from these neu- roscientific studies are coupled

Gazzaniga, Michael

469

Human EmbryologyKeibel and Mall  

Science Journals Connector (OSTI)

...study of human material. Much of the greatest...there is now ample material for satis-factory...energy and skill in handling the material, to which he has...valuable figures and diagrams. The skeleton...contributions from the au-thor, many figures...

H. MCE. KNOWER

1911-03-31T23:59:59.000Z

470

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network (OSTI)

, planning, development and construction. Issues of sustainability and green building are among the areas of Design and Building, the School of the Arts, and the School of Humanities. Advanced degrees are of- fered; Planning, Design and the Built Environment; Professional Communication; Real Estate Development; Rhetorics

Bolding, M. Chad

471

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network (OSTI)

contemporary issues of design, planning, development and construction. Issues of sustain- ability and green of Design and Building, the School of the Arts, and the School of Humanities. Advanced degrees are of- fered; Planning, Design and the Built Environment; Professional Communication; Real Estate Development; Rhetorics

Stuart, Steven J.

472

Modelling the evolution of human trail systems  

Science Journals Connector (OSTI)

... Many human social phenomena, such as cooperation, the growth of settlements, traffic dynamics and pedestrian movement, appear to be accessible to mathematical descriptions that invoke self-organization. Here we ... be accessible to mathematical descriptions that invoke self-organization. Here we develop a model of pedestrian motion to explore the evolution of trails in urban green spaces such as parks. ...

Dirk Helbing; Joachim Keltsch; Pter Molnr

1997-07-03T23:59:59.000Z

473

Highland Hospital Human Resources Policy Manual  

E-Print Network (OSTI)

Highland Hospital Human Resources Policy Manual Policy Statements Policy #106 Reviewed: 04/26/12 POLICY: This Policy reaffirms Highland Hospital's commitment to nondiscrimination, equal opportunity, and affirmative action in employment and equal access to and treatment in Hospital programs and activities

Goldman, Steven A.

474

Division of Human Resources Nonresident Alien Federal  

E-Print Network (OSTI)

Division of Human Resources Nonresident Alien Federal Withholding Requirements Questions (813) 974 classified as nonresident aliens for tax purposes with regard to their federal withholding taxes.gov. In brief, the Form W-4 requirements for individuals who are nonresident aliens (NRA) for tax purposes

Meyers, Steven D.

475

Human Resources Security Access Matrix Function Training  

E-Print Network (OSTI)

June 2013 Human Resources Security Access Matrix Function Training Course Required Class Mode Training Course Prerequisite Security Access Form Required Contact for Additional Information Complete Electronic I-9 Forms REC001: I-9 /E-Verify Web Training OR Online OR None Electronic I-9 Security Access Form

Wu, Shin-Tson

476

Finite element decomposition of the human neocortex  

E-Print Network (OSTI)

. . . . . . . . . . . . . . . . . . . . . ?. .. . , . . . . . C. Application of Software Tools to the Human Neocortex. . . . . . . . 72 . . . . 72 . . . . 74 VIII RESULTS. . . . . 77 A. B. C. D. E. F. Contour Extraction . , Solid Model Reconstruction of the Right Hemisphere. . . . Extraction.... Summary. B. Future Work. . . . . . 101 . . . . . 101 REFERENCES. , . . . . . 105 . . . . . 110 LIST OF FIGURES FIGURE Page 1 Reconstruction stages. . . . . . 2 Voronoi diagram and Delaunay triangulation . . . . . 13 3 IVS and EVS of two contours...

Chow, Seeling

2012-06-07T23:59:59.000Z

477

Moral responsibility and IT for human enhancement.  

Science Journals Connector (OSTI)

What can be said against a moral obligation to use IT for enhancement purposes? Some have argued - and it is very well conceivable that this is an increasingly common conception - that we may have a moral obligation to use IT for enhancing human bodies ... Keywords: computer ethics, enhancement, epistemic dependence, epistemic paternalism, moral deskilling, moral responsibility

Nomi Manders-Huits

2006-04-01T23:59:59.000Z

478

Social intelligence, human intelligence and niche construction  

Science Journals Connector (OSTI)

...with our complex systems of communication...expensive brains (Aiello Wheeler 1995). As group...world. 1 Indeed, Foster Ratnieks (2005...and the digestive system in human and primate...evan.10108 . Foster, K , Ratnieks...theory and empirical studies. Annu. Rev. Anthropol...

2007-01-01T23:59:59.000Z

479

Division of Human Resources Important Documents, Terms  

E-Print Network (OSTI)

Division of Human Resources Important Documents, Terms and Procedures Questions (813) 974 of eligibility, financial information, etc. It is not the visa document. I-20 ­ The Certificate of Eligibility is intended to keep track of arrivals & departures to and from the United States. Duration of Status (D

Meyers, Steven D.

480

French Studies The School of Humanities  

E-Print Network (OSTI)

1 French Studies The School of Humanities Degrees Offered: BA, MA, PhD Courses in this department hone language skills in French while placing a diverse, generalized knowledge of French literature within a broad spectrum of cultural, historical, philosophical, and theoretical concerns. Students also

Richards-Kortum, Rebecca

Note: This page contains sample records for the topic "human mammary epithelial" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

French Studies The School of Humanities  

E-Print Network (OSTI)

181 French Studies The School of Humanities Degrees Offered: BA, MA, PhD Courses in this department hone language skills in French while placing a diverse, generalized knowledge of French literature within a broad spectrum of cultural, historical, philosophical, and theoretical concerns. Students also

Richards-Kortum, Rebecca

482

French Studies The School of Humanities  

E-Print Network (OSTI)

164 French Studies The School of Humanities Chair Bernard Aresu Professors Madeleine Alcover Jean in this department hone language skills in French while placing a diverse, generalized knowledge of French literature within a broad spectrum of cultural, histori- cal, philosophical, and theoretical concerns. Students

Richards-Kortum, Rebecca

483

French Studies The School of Humanities  

E-Print Network (OSTI)

of French literature within a broad spectrum of cultural, histori- cal, philosophical, and theoretical179 French Studies The School of Humanities Chair Michel Achard Professors Madeleine Alcover.D. Courses in this department hone language skills in French while placing a diverse, generalized knowledge

Richards-Kortum, Rebecca

484

BachelorofArts GeneralMajorintheHumanities  

E-Print Network (OSTI)

in the Humanities, the Social Sciences and the Sciences.The main emphasis of the General Major is to provide a broad, if French 1500 is required in your program, you could not use French (1000 level) to fulfill English - all courses One of French, German or Spanish (Linguistics 2300 may be substituted for one

Seldin, Jonathan P.

485

French Studies The School of Humanities  

E-Print Network (OSTI)

174 French Studies The School of Humanities Degrees Offered: BA, MA, PhD Courses in this department hone language skills in French while placing a diverse, generalized knowledge of French literature within a broad spectrum of cultural, historical,philosophical,and theoretical concerns.Students are also

Richards-Kortum, Rebecca

486

French Studies The School of Humanities  

E-Print Network (OSTI)

189 French Studies The School of Humanities Degrees Offered: BA, MA, PhD Courses in this department hone language skills in French while placing a diverse, generalized knowledge of French literature within a broad spectrum of cultural, historical, philosophical, and theoretical concerns. Students also

Richards-Kortum, Rebecca

487

French Studies The School of Humanities  

E-Print Network (OSTI)

176 French Studies The School of Humanities Degrees Offered: BA, MA, PhD Courses in this department hone language skills in French while placing a diverse, generalized knowledge of French literature within a broad spectrum of cultural, historical,philosophical,and theoretical concerns.Students are also

Richards-Kortum, Rebecca

488

HUMAN RESOURCES 3 February 2012 UNIVERSITET  

E-Print Network (OSTI)

Officer Margit Troelsen, tel. 871 53348 e-mail; mt@teo.au.dk > Personnel Officer Dorte Moe Jakobsen, tel. 871 53327 > e-mail; dmj@adm.au.dk > Personnel Office, AU HR #12;HUMAN RESOURCES 3 February 2012 AARHUS

489

Human Cytomegalovirus Resistance to Antiviral Drugs  

Science Journals Connector (OSTI)

American Society for Microbiology MINIREVIEW MINIREVIEW Human...Resistance to Antiviral Drugs C. Gilbert 1 G. Boivin 1 Corresponding...523-528. 20 Boivin, G., C. Gilbert, A. Gaudreau, I. Greenfield...G., N. Goyette, C. Gilbert, N. Roberts, K. Macey...

C. Gilbert; G. Boivin

2005-03-01T23:59:59.000Z

490

A physical map of the human genome  

Science Journals Connector (OSTI)

... fingerprinted clones (primarily radiation hybrid chromosomal localization data from the Stanford Human Genome Center (SHGC)). The parameters finally used (overlap statistic of 3??10-12 or about ... http://carbon.wi.mit.edu:8000/cgi-bin/contig/phys_map), GeneMap99, SHGC G3 radiation hybrid map (http://www- ...

2001-02-15T23:59:59.000Z

491

Extending Human Presence into the Solar System  

E-Print Network (OSTI)

Extending Human Presence into the Solar System An Independent Study for The Planetary Society the development of additional assets, including an uprated CEV capable of extended missions of many months lengthy hiatus in the ability of the United States to conduct crewed spaceflight operations. To this end

Rathbun, Julie A.

492

INDOOR AIR QUALITY QUESTIONNAIRE HUMAN RESOURCES  

E-Print Network (OSTI)

INDOOR AIR QUALITY QUESTIONNAIRE HUMAN RESOURCES FORM Risk and Compliance | One Washington Square THE AIR QUALITY ISSUE AND LOCATION Name: Date: Department: Phone No: Work Location: Suspected Air Quality, humidity, drafts, stagnant air, odors)? Is there a history of flooding or water damage? If so, please list

Eirinaki, Magdalini

493

West Virginia University Division of Human Resources  

E-Print Network (OSTI)

Resources Web page hr.wvu.edu. In the event of a conflict between the current posted version and this printed copy, the posted version on the Web page is controlling. Page 1 of 9 Family Medical Leave Act Division of Human Resources Web page hr.wvu.edu. In the event of a conflict between the current posted

Mohaghegh, Shahab

494

College of Human and Health Sciences  

E-Print Network (OSTI)

8988 College of Human and Health Sciences All research is delivered through discipline-focused research centres, which examine fields such as child research, ageing, psychology and social care, as well as midwifery, nursing and allied health professions. External funding from a number of prestigious bodies has

Harman, Neal.A.

495

Exploring Paradigms of Human Resource Development  

E-Print Network (OSTI)

This study focused on the issue of paradigms in Human Resource Development (HRD). Its purpose was to validate the HRD Cube as a synthesized model of HRD and to explicate some of the extant paradigms of HRD. The study was carried out by examining...

Hurt, Andrew Christopher

2011-10-21T23:59:59.000Z

496

Initial characerization of human spermine oxidase  

E-Print Network (OSTI)

recombinant protein. The enzyme requires co-expression with chaperone proteins GroEL and GroES to remain soluble and active. Purification requires the use of a Ni-NTA and size exclusion column. Human spermine oxidase is a monomer with an extinction coefficient...

Juarez, Paul Ramon

2009-05-15T23:59:59.000Z

497

Human perception of shape from touch  

Science Journals Connector (OSTI)

...virtual worlds: what subjects cannot feel, does not have to be simulated. Static and dynamic...LedermanS. J. 1986 Tactual perception. In Handbook of perception and human performance, volume...immediate contact with the stimulus, that does only partially transfer to the other hand...

2011-01-01T23:59:59.000Z

498

Japan increases share of Human Frontier awards  

Science Journals Connector (OSTI)

... Tokyo. Japan's scientists performed well in the latest round of awards from the Strasbourg-based Human ... for international research on the brain and biological functions announced last week also show that Japan is the least popular destination for bright young scientists.

David Swinbanks

1993-04-15T23:59:59.000Z

499

Becoming sustainable: Human determinants of change  

Science Journals Connector (OSTI)

Abstract The author is a natural scientist and philosopher who has been involved in the global experience industry for more than 25years. During this period of time he has developed a coherent, interdisciplinary body of knowledge that appears to be of essential interest as related to the transition towards a sustainable society: the Experience Science (Frank, 2011, 2012). Important scientific inputs come from underlying disciplines like cybernetics, system theory, psychology, and cognitive science. One of the key findings of the Experience Science is the innate structure of human experiencing. Any human experience includes 5 different experiential domains that influence and regulate each other: the emotional domain (feeling); the mental imagery domain (mental narrating); the sensorimotor domain (acting & perceiving); the linguistic domain (rational reasoning); the communicational domain (conversing). In the light of the Experience Science the dilemma of the current transition process towards a sustainable society becomes clearly visible. Any relevant attempt reduces the existing problems to more or less exclusively the linguistic, rational domain. Although ever evolving rational knowledge indeed is an indispensable prerequisite for a sustainable future this is not enough. Societal change towards a sustainable life-style can only happen if the whole experiential system gets a chance to reorganize itself. This leads to the following logical consequence. Any rational knowledge is embedded in a both emotional and narrative knowledge system that underlies and frames human reasoning. As long as human learning restricts itself to an exclusively rational attempt the underlying emotional and narrative program remains untouched. The learner hence continues orienting her attention into the direction determined by the underlying emotional and narrative paradigm. The paper delineates the experiential determinants of change and analyzes their specific, constitutive interrelations. From this a holistic choreography of change learning is outlined that pays tribute to the intrinsic transition principles represented by the human learner.

Gerhard Frank

2014-01-01T23:59:59.000Z

500

Office of Human Resources and Administration - Mission and Functions  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Resources and Administration Human Resources and Administration Home Sub Offices › Business Operations › Human Resources and Administration › Information Management Mission & Functions › Information Management › Human Resources and Adminstration › Business Operations HSS Logo Office of Human Resources and Administration Reports to the Office of Resource Management Mission and Functions Mission The Office of Human Resources and Administration provides a broad range of human resource and administrative management activities in support of the Office of Health, Safety and Security (HSS). Functions Integrates, synchronizes, and concentrates human resource management activities in support of HSS, Departmental leadership, and other customers. Assists HSS managers in recruiting and hiring qualified, talented and capable candidates. Advises and informs HSS managers on hiring requirements, capabilities, and limitations. Assists managers, candidates, and new employees through the employment process. Manages special hiring programs such as interns, disadvantaged and minorities.