National Library of Energy BETA

Sample records for human factors decision

  1. A decision support system prototype including human factors based on the TOGA meta-theory approach

    SciTech Connect (OSTI)

    Cappelli, M.; Memmi, F.; Gadomski, A. M.; Sepielli, M.

    2012-07-01

    The human contribution to the risk of operation of complex technological systems is often not negligible and sometimes tends to become significant, as shown by many reports on incidents and accidents occurred in the past inside Nuclear Power Plants (NPPs). An error of a human operator of a NPP can derive by both omission and commission. For instance, complex commission errors can also lead to significant catastrophic technological accidents, as for the case of the Three Mile Island accident. Typically, the problem is analyzed by focusing on the single event chain that has provoked the incident or accident. What is needed is a general framework able to include as many parameters as possible, i.e. both technological and human factors. Such a general model could allow to envisage an omission or commission error before it can happen or, alternatively, suggest preferred actions to do in order to take countermeasures to neutralize the effect of the error before it becomes critical. In this paper, a preliminary Decision Support System (DSS) based on the so-called (-) TOGA meta-theory approach is presented. The application of such a theory to the management of nuclear power plants has been presented in the previous ICAPP 2011. Here, a human factor simulator prototype is proposed in order to include the effect of human errors in the decision path. The DSS has been developed using a TRIGA research reactor as reference plant, and implemented using the LabVIEW programming environment and the Finite State Machine (FSM) model The proposed DSS shows how to apply the Universal Reasoning Paradigm (URP) and the Universal Management Paradigm (UMP) to a real plant context. The DSS receives inputs from instrumentation data and gives as output a suggested decision. It is obtained as the result of an internal elaborating process based on a performance function. The latter, describes the degree of satisfaction and efficiency, which are dependent on the level of responsibility related to each professional role. As an application, we present the simulation of the discussed error, e.g. the unchecked extraction of the control rods during a power variation maneuver and we show how the effect of human errors can affect the performance function, giving rise to different countermeasures which could call different operator figures into play, potentially not envisaged in the standard procedure. (authors)

  2. PROCEEDINGS of the HUMAN FACTORS AND ERGONOMICS SOCIETY 45th ANNUAL MEETING-2001 TESTBED FOR EVALUATING TACTICAL SITUATION AWARENESS AND DECISION

    E-Print Network [OSTI]

    Virginia, University of

    PROCEEDINGS of the HUMAN FACTORS AND ERGONOMICS SOCIETY 45th ANNUAL MEETING- 2001 TESTBED FOR EVALUATING TACTICAL SITUATION AWARENESS AND DECISION MAKING Stephanie Guerlain, Rob Willis, Julie Besselman have developed a testbed for evaluating alternative display concepts and decision support features

  3. Human Factors @ UB Fall 2010 Human Factors

    E-Print Network [OSTI]

    Krovi, Venkat

    . Outsourcing aviation maintenance: Hu- man factors implications, specifically for communications. C. Drury, K. Guy, C. Wenner. International Journal of Aviation Psychology, 2010, 20, 124 ­ 143. #12;2 Human Factors

  4. Simulation of human decision making

    DOE Patents [OSTI]

    Forsythe, J. Chris (Sandia Park, NM); Speed, Ann E. (Albuquerque, NM); Jordan, Sabina E. (Albuquerque, NM); Xavier, Patrick G. (Albuquerque, NM)

    2008-05-06

    A method for computer emulation of human decision making defines a plurality of concepts related to a domain and a plurality of situations related to the domain, where each situation is a combination of at least two of the concepts. Each concept and situation is represented in the computer as an oscillator output, and each situation and concept oscillator output is distinguishable from all other oscillator outputs. Information is input to the computer representative of detected concepts, and the computer compares the detected concepts with the stored situations to determine if a situation has occurred.

  5. Human Factors of Reporting Systems

    E-Print Network [OSTI]

    Johnson, C.W.

    Johnson,C.W. P. Carayon (ed.), A Handbook of Human Factors and Ergonomics in Healthcare and Patient Safety, Lawrence Erlbaum, London, UK. pp 715-750 Lawrence Erlbaum Associates

  6. Human factors in software development

    SciTech Connect (OSTI)

    Curtis, B.

    1986-01-01

    This book presents an overview of ergonomics/human factors in software development, recent research, and classic papers. Articles are drawn from the following areas of psychological research on programming: cognitive ergonomics, cognitive psychology, and psycholinguistics. Topics examined include: theoretical models of how programmers solve technical problems, the characteristics of programming languages, specification formats in behavioral research and psychological aspects of fault diagnosis.

  7. Rice Quality Factors: Implications For Management Decisions

    E-Print Network [OSTI]

    Grant, Warren R.; Rister, Edward, M.; Brorsen, B. Wade

    1986-01-01

    . Review comments and suggestions from Bill Black, Bart Drees, Arthur Gerlow, Melvin Parker, James Stansel, Mo Way, Bill Webb, and Michael Wohlgenant are also appreciated. A special thanks to Kim Trant for editorial assistance. ... Rice Quality Factors... that grades are intended to measure are red rice, weed seeds, damaged kernels (including peck), off-color, chalk, and off-types of rice kernels. These factors should be negatively related to price, since they are all undesirable characteristics. 1 Graders...

  8. Human factors in waste management

    SciTech Connect (OSTI)

    Moray, N.

    1994-10-01

    This article examines the role of human factors in radioactive waste management. Although few problems and ergonomics are special to radioactive waste management, some problems are unique especially with long term storage. The entire sociotechnical system must be looked at in order to see where improvement can take place because operator errors, as seen in Chernobyl and Bhopal, are ultimately the result of management errors.

  9. Human factors: a necessary tool for industry

    SciTech Connect (OSTI)

    Starcher, K.O.

    1984-03-09

    The need for human factors (ergonomics) input in the layout of a ferroelectric ceramics laboratory is presented as an example of the overall need for human factors professionals in industry. However, even in the absence of one trained in human factors, knowledge of a few principles in ergonomics will provide many possibilities for improving performance in the industrial environment.

  10. Accommodating complexity and human behaviors in decision analysis.

    SciTech Connect (OSTI)

    Backus, George A.; Siirola, John Daniel; Schoenwald, David Alan; Strip, David R.; Hirsch, Gary B.; Bastian, Mark S.; Braithwaite, Karl R.; Homer, Jack [Homer Consulting

    2007-11-01

    This is the final report for a LDRD effort to address human behavior in decision support systems. One sister LDRD effort reports the extension of this work to include actual human choices and additional simulation analyses. Another provides the background for this effort and the programmatic directions for future work. This specific effort considered the feasibility of five aspects of model development required for analysis viability. To avoid the use of classified information, healthcare decisions and the system embedding them became the illustrative example for assessment.

  11. Coupling control and human factors in mathematical models of complex systems

    E-Print Network [OSTI]

    Melnik, Roderick

    Coupling control and human factors in mathematical models of complex systems Roderick V.N. Melnik à that in the analysis and control of such systems, human factors should not be eliminated by conventional formal transportation systems (ITS) theory and practice, the problem of speed control, considered here as a decision

  12. Psychology 4330, Spring 2011. Human Factors Engineering

    E-Print Network [OSTI]

    Sanders, Matthew

    with an interest in design should remember that it is not really possible to teach ergonomic design per se without: Guastello, S. J. (2006). Human factors engineering and ergonomics: A systems approach. Mahwah, NJ: Lawrence/19 Introduction to human factors (T1) 1/24 Usability evaluation methods (T2) 1/31 Systems that change over time (T

  13. Modeling and analysis of affective influences on human experience, prediction, decision making, and behavior

    E-Print Network [OSTI]

    Ahn, Hyungil, 1976-

    2010-01-01

    Subjective and affective elements are well-known to influence human decision making. This dissertation presents a theoretical and empirical framework on how human decision makers' subjective experience and affective ...

  14. Human factors challenges for advanced process control

    SciTech Connect (OSTI)

    Stubler, W.F.; O`Hara, J..M.

    1996-08-01

    New human-system interface technologies provide opportunities for improving operator and plant performance. However, if these technologies are not properly implemented, they may introduce new challenges to performance and safety. This paper reports the results from a survey of human factors considerations that arise in the implementation of advanced human-system interface technologies in process control and other complex systems. General trends were identified for several areas based on a review of technical literature and a combination of interviews and site visits with process control organizations. Human factors considerations are discussed for two of these areas, automation and controls.

  15. Human Factors of Healthcare Reporting Systems

    E-Print Network [OSTI]

    Johnson, C.W.

    Johnson,C.W. P. Carayon (ed), A Handbook of Human Factors and Ergonomics in Healthcare and Patient Safety, Lawrence Erlbaum, London, UK pp 525-560 Lawrence Erlbaum Associates

  16. Human factors in nuclear technology - a history

    SciTech Connect (OSTI)

    Jones, D.B. )

    1992-01-01

    Human factors, human factors engineering (HFE), or ergonomics did not receive much formal attention in nuclear technology prior to the Three Mile Island Unit 2 (TMI-2) incident. Three principal reasons exist for this lack of concern. First, emerging technologies show little concern with how people will use a new system. Making the new technology work is considered more important than the people who will use it. Second, the culture of the users of nuclear power did not recognize a need for human factors. Traditional utilities had well established and effective engineering designs for control of electric power generation, while medicine considered the use of nuclear isotopes another useful tool, not requiring special ergonomics. Finally, the nuclear industry owed much to Admiral Rickover. He was definitely opposed.

  17. HUMAN FACTORS GUIDANCE FOR CONTROL ROOM EVALUATION

    SciTech Connect (OSTI)

    OHARA,J.; BROWN,W.; STUBLER,W.; HIGGINS,J.; WACHTEL,J.; PERSENSKY,J.J.

    2000-07-30

    The Human-System Interface Design Review Guideline (NUREG-0700, Revision 1) was developed by the US Nuclear Regulatory Commission (NRC) to provide human factors guidance as a basis for the review of advanced human-system interface technologies. The guidance consists of three components: design review procedures, human factors engineering guidelines, and a software application to provide design review support called the ``Design Review Guideline.'' Since it was published in June 1996, Rev. 1 to NUREG-0700 has been used successfully by NRC staff, contractors and nuclear industry organizations, as well as by interested organizations outside the nuclear industry. The NRC has committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool in the face of emerging and rapidly changing technology. This paper addresses the current research to update of NUREG-0700 based on the substantial work that has taken place since the publication of Revision 1.

  18. Annotated bibliography of human factors applications literature

    SciTech Connect (OSTI)

    McCafferty, D.B.

    1984-09-30

    This bibliography was prepared as part of the Human Factors Technology Project, FY 1984, sponsored by the Office of Nuclear Safety, US Department of Energy. The project was conducted by Lawrence Livermore National Laboratory, with Essex Corporation as a subcontractor. The material presented here is a revision and expansion of the bibliographic material developed in FY 1982 as part of a previous Human Factors Technology Project. The previous bibliography was published September 30, 1982, as Attachment 1 to the FY 1982 Project Status Report.

  19. Integrating human and robot decision-making dynamics with feedback: Models and convergence analysis

    E-Print Network [OSTI]

    Leonard, Naomi

    , a well-studied decision-making task in behavioral experiments. The human subject chooses between two structures, the behavioral experiments show convergence to suboptimal choices. We propose a human- supervised and the kinds of decisions humans make in psychology experiments. We consider a class of sequential binary

  20. Integrating Human Factors with Software Engineering Practices

    E-Print Network [OSTI]

    of the 38th Annual Meeting of the Human Factors and Ergonomics Society, Nashville, TN, October, 1994. Also to the design, development, and evaluation of usable and useful interactive systems, and presents a rationale Ergonomics and Safety Technology, Inc. Pittsburgh, PA 15213 USA jtr001@delphi.com 1. Introduction The design

  1. Communication Factors Affecting African Policymakers' Decisions about Agricultural Biotechnology 

    E-Print Network [OSTI]

    Begashaw, Belay Ejigu

    2010-10-12

    The purpose of this study was to develop a model for impacting decisions on agricultural biotechnology practices in food production among African policymakers. The research focused on three African countries, namely, South Africa, Malawi and Ghana...

  2. Human-automation collaboration : decision support for lunar and planetary exploration

    E-Print Network [OSTI]

    Márquez, Jessica J., 1976-

    2007-01-01

    Balancing task allocation between humans and computers is crucial to the development of effective decision support systems. This thesis investigates the appropriate balance between humans and automation for geospatial path ...

  3. Technology and Architecture: Informing Investment Decisions for the Future of Human Space Exploration

    E-Print Network [OSTI]

    de Weck, Olivier L.

    Technology and Architecture: Informing Investment Decisions for the Future of Human Space;2 #12;3 Technology and Architecture Informing Investment Decisions for the Future of Human Space before the system architecture is defined. This thesis develops a framework for evaluating technologies

  4. Human factors engineering program review model

    SciTech Connect (OSTI)

    Not Available

    1994-07-01

    The staff of the Nuclear Regulatory Commission is performing nuclear power plant design certification reviews based on a design process plan that describes the human factors engineering (HFE) program elements that are necessary and sufficient to develop an acceptable detailed design specification and an acceptable implemented design. There are two principal reasons for this approach. First, the initial design certification applications submitted for staff review did not include detailed design information. Second, since human performance literature and industry experiences have shown that many significant human factors issues arise early in the design process, review of the design process activities and results is important to the evaluation of an overall design. However, current regulations and guidance documents do not address the criteria for design process review. Therefore, the HFE Program Review Model (HFE PRM) was developed as a basis for performing design certification reviews that include design process evaluations as well as review of the final design. A central tenet of the HFE PRM is that the HFE aspects of the plant should be developed, designed, and evaluated on the basis of a structured top-down system analysis using accepted HFE principles. The HFE PRM consists of ten component elements. Each element in divided into four sections: Background, Objective, Applicant Submittals, and Review Criteria. This report describes the development of the HFE PRM and gives a detailed description of each HFE review element.

  5. Human Factors Aspects of Power System Flow Animation

    E-Print Network [OSTI]

    Human Factors Aspects of Power System Flow Animation Douglas A. Wiegmann, Gavin R. Essenberg experimental results associated with human factors aspects of using animation to display electric power system. Index Terms--Power System Operations and Planning, Power System Visualization, Animation, Human Factors

  6. Human Factors and Data Fusion as Part of Control Systems Resilience

    SciTech Connect (OSTI)

    David I. Gertman

    2009-05-01

    Human performance and human decision making is counted upon as a crucial aspect of overall system resilience. Advanced control systems have the potential to provide operators and asset owners a wide range of data, deployed at different levels that can be used to support operator situation awareness. However, the sheer amount of data available can make it challenging for operators to assimilate information and respond appropriately. This paper reviews some of the challenges and issues associated with providing operators with actionable state awareness and argues for the over arching importance of integrating human factors as part of intelligent control systems design and implementation. It is argued that system resilience is improved by implementing human factors in operations and maintenance. This paper also introduces issues associated with resilience and data fusion and highlights areas in which human factors including field studies hold promise.

  7. Learned Human-in-the-Loop Decision Making

    E-Print Network [OSTI]

    Basso, Brandon

    2012-01-01

    that it was human. - Alan Turing Introduction Learning is agreat frequency. - Alan Turing Introduction The Generalized

  8. http://rev.sagepub.com/ Reviews of Human Factors and

    E-Print Network [OSTI]

    http://rev.sagepub.com/ Ergonomics Reviews of Human Factors and http://rev.sagepub.com/content/7 Factors and Ergonomics Michael A. Nees and Bruce N. Walker Auditory Displays for In-Vehicle Technologies Published by: http://www.sagepublications.com On behalf of: Human Factors and Ergonomics Society at: can

  9. Human Factors for Situation Assessment in Grid Operations

    SciTech Connect (OSTI)

    Guttromson, Ross T.; Schur, Anne; Greitzer, Frank L.; Paget, Mia L.

    2007-08-08

    Executive Summary Despite advances in technology, power system operators must assimilate overwhelming amounts of data to keep the grid operating. Analyses of recent blackouts have clearly demonstrated the need to enhance the operator’s situation awareness (SA). The long-term objective of this research is to integrate valuable technologies into the grid operator environment that support decision making under normal and abnormal operating conditions and remove non-technical barriers to enable the optimum use of these technologies by individuals working alone and as a team. More specifically, the research aims to identify methods and principles to increase SA of grid operators in the context of system conditions that are representative or common across many operating entities and develop operationally relevant experimental methods for studying technologies and operational practices which contribute to SA. With increasing complexity and interconnectivity of the grid, the scope and complexity of situation awareness have grown. New paradigms are needed to guide research and tool development aimed to enhance and improve operations. In reviewing related research, operating practices, systems, and tools, the present study established a taxonomy that provides a perspective on research and development surrounding power grid situation awareness and clarifies the field of human factors/SA for grid operations. Information sources that we used to identify critical factors underlying SA included interviews with experienced operational personnel, available historical summaries and transcripts of abnormal conditions and outages (e.g., the August 14, 2003 blackout), scientific literature, and operational policies/procedures and other documentation. Our analysis of August 2003 blackout transcripts and interviews adopted a different perspective than previous analyses of this material, and we complemented this analysis with additional interviews. Based on our analysis and a broad literature review, we advocate a new perspective on SA in terms of sensemaking, also called situated or ecological decision making, where the focus of the investigation is to understand why the decision maker(s) experienced the situation the way they did, or why what they saw made sense to them at the time. This perspective is distinct from the traditional branch of human factors research in the field which focuses more on ergonomics and the transactional relationship between the human operator and the systems. Consistent with our findings from the literature review, we recognized an over-arching need to focus SA research on issues surrounding the concept of shared knowledge; e.g., awareness of what is happening in adjacent areas as well as one’s own area of responsibility. Major findings were: a) Inadequate communication/information sharing is pervasive, b) Information is available, but not used. Many tools and mechanisms exist for operators to build awareness of the physical grid system, yet the transcripts reveal that they still need to call and exchange information with operators of neighboring areas to improve or validate their SA. The specific types of information that they request are quite predictable and, in most cases, cover information that could be available to both operators and reliability coordinators through readily available displays or other data sources, c) Shared Knowledge is Required on Operations/Actions as Well as Physical Status. In an ideal, technologically and organizationally perfect world, every control room and every reliability coordinator may have access to complete data across all regional control areas and yet, there would still be reason for the operators to call each other to gain and improve their SA of power grid operations, and d) Situation Awareness as sensemaking and shared knowledge.

  10. Human Factors Aspects of Operating Small Reactors

    SciTech Connect (OSTI)

    OHara, J.M.; Higgins, J.; Deem, R.; Xing, J.; DAgostino, A.

    2010-11-07

    The nuclear-power community has reached the stage of proposing advanced reactor designs to support power generation for decades to come. They are considering small modular reactors (SMRs) as one approach to meet these energy needs. While the power output of individual reactor modules is relatively small, they can be grouped to produce reactor sites with different outputs. Also, they can be designed to generate hydrogen, or to process heat. Many characteristics of SMRs are quite different from those of current plants, and so may require a concept of operations (ConOps) that also is different. The U.S. Nuclear Regulatory Commission (NRC) has begun examining the human factors engineering- (HFE) and ConOps- aspects of SMRs; if needed, they will formulate guidance to support SMR licensing reviews. We developed a ConOps model, consisting of the following dimensions: Plant mission; roles and responsibilities of all agents; staffing, qualifications, and training; management of normal operations; management of off-normal conditions and emergencies; and, management of maintenance and modifications. We are reviewing information on SMR design to obtain data about each of these dimensions, and have identified several preliminary issues. In addition, we are obtaining operations-related information from other types of multi-module systems, such as refineries, to identify lessons learned from their experience. Here, we describe the project's methodology and our preliminary findings.

  11. Applying Human Factors to the Design of Performance Tools

    E-Print Network [OSTI]

    Pancake, Cherri M.

    Applying Human Factors to the Design of Performance Tools Cherri M. Pancake Oregon State University Abstract. After two decades of research in parallel tools for perfor- mance tuning, why are users still dissatis ed? This paper outlines the human factors issues that determine how performance tools

  12. Human Reliability Analysis for Design: Using Reliability Methods for Human Factors Issues

    SciTech Connect (OSTI)

    Ronald Laurids Boring

    2010-11-01

    This paper reviews the application of human reliability analysis methods to human factors design issues. An application framework is sketched in which aspects of modeling typically found in human reliability analysis are used in a complementary fashion to the existing human factors phases of design and testing. The paper provides best achievable practices for design, testing, and modeling. Such best achievable practices may be used to evaluate and human system interface in the context of design safety certifications.

  13. Agent-based modeling of human decision-making behavior within Spatial Decision Support Systems

    E-Print Network [OSTI]

    Sengupta, Raja

    on modeling humans as spatial "agents" that impact the landscape in some fashion. For example, considerable characteristics of the individual, such as age and income, and spatial characteristics of their land holdings for a period of ten years. Modeling Farmers as Agents Traditionally, neoclassical economic theories and profit-maximizing

  14. Gray, W. D. (2003). Cognitive factors in homeland defense: The role of human factors in the novel intelligence from massive data (NIMD) project, Human Factors and Ergonomics Society (pp. 1017-1018). Santa Monica, CA: Human

    E-Print Network [OSTI]

    Gray, Wayne

    2003-01-01

    intelligence from massive data (NIMD) project, Human Factors and Ergonomics Society (pp. 1017-1018). Santa Monica, CA: Human Factors and Ergonomics Society. COGNITIVE FACTORS IN HOMELAND DEFENSE: THE ROLE

  15. Human factors survey of advanced instrumentation and controls

    SciTech Connect (OSTI)

    Carter, R.J.

    1989-01-01

    A survey oriented towards identifying the human factors issues in regard to the use of advanced instrumentation and controls (I C) in the nuclear industry was conducted. A number of United States (US) and Canadian nuclear vendors and utilities were participants in the survey. Human factors items, subsumed under the categories of computer-generated displays (CGD), controls, organizational support, training, and related topics, were discussed. The survey found the industry to be concerned about the human factors issues related to the implementation of advanced I C. Fifteen potential human factors problems were identified. They include: the need for an advanced I C guideline equivalent to NUREG-0700; a role change in the control room from operator to supervisor; information overload; adequacy of existing training technology for advanced I C; and operator acceptance and trust. 11 refs., 1 tab.

  16. Factors which affect programming decision-making of public information radio tape service by Spanish-language broadcasters in Texas 

    E-Print Network [OSTI]

    Pina, Manuel

    1974-01-01

    FACTORS WHICH AFFECT PROGRAMMING DECISION-MAKING OF PUBLIC INFORMATION RADIO TAPE SERVICE BY SPANISH-LANGUAGE BROADCASTERS IN TEXAS A Thesis by MANUEL Pl NA, JR. Submitted to the Graduate College of Texas A&M University in partial... fulfillment of the requirement for the degree of MASTER OF SCIENCE August 1974 Major Subject: Educational Administration (public Relations) FACTORS WHICH AFFECT PROGRAMMING DECISION-MAKING OF PUBLIC INFORMATION RADIO TAPE SERVICE BY SPANISH...

  17. UPDATING THE NRC GUIDANCE FOR HUMAN FACTORS ENGINEERING REVIEWS.

    SciTech Connect (OSTI)

    O HARA,J.M.; BROWN,W.S.; HIGGINS,J.C.; PERSENSKY,J.J.; LEWIS,P.M.; BONGARRA,J.

    2002-09-15

    The U.S. Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) aspects of nuclear plants. NUREG-0800 (Standard Review Plan), Chapter 18, ''Human Factors Engineering,'' is the principal NRC staff guidance document. Two main documents provide the review criteria to support the evaluations. The HFE Program Review Model (NUREG-0711) addresses the design process from planning to verification and validation to design implementation. The Human-System Interface Design Review Guidelines (NUREG-0700) provides the guidelines for the review of the HFE aspects of human-system interface technology, such as alarms, information systems, controls, and control room design. Since these documents were published in 1994 and 1996 respectively, they have been used by NRC staff, contractors, nuclear industry organizations, as well as by numerous organizations outside the nuclear industry. Using feedback from users and NRC research conducted in recent years, both documents have been revised and updated. This was done to ensure that they remain state-of-the-art evaluation tools for changing nuclear industry issues and emerging technologies. This paper describes the methodology used to revise and update the documents and summarizes the changes made to each and their current contents. Index Terms for this report are: Control system human factors, Ergonomics, Human factors, Nuclear power generation safety.

  18. Human factors engineering report for the cold vacuum drying facility

    SciTech Connect (OSTI)

    IMKER, F.W.

    1999-06-30

    The purpose of this report is to present the results and findings of the final Human Factors Engineering (HFE) technical analysis and evaluation of the Cold Vacuum Drying Facility (CVDF). Ergonomics issues are also addressed in this report, as appropriate. This report follows up and completes the preliminary work accomplished and reported by the Preliminary HFE Analysis report (SNF-2825, Spent Nuclear Fuel Project Cold Vacuum Drying Facility Human Factors Engineering Analysis: Results and Findings). This analysis avoids redundancy of effort except for ensuring that previously recommended HFE design changes have not affected other parts of the system. Changes in one part of the system may affect other parts of the system where those changes were not applied. The final HFE analysis and evaluation of the CVDF human-machine interactions (HMI) was expanded to include: the physical work environment, human-computer interface (HCI) including workstation and software, operator tasks, tools, maintainability, communications, staffing, training, and the overall ability of humans to accomplish their responsibilities, as appropriate. Key focal areas for this report are the process bay operations, process water conditioning (PWC) skid, tank room, and Central Control Room operations. These key areas contain the system safety-class components and are the foundation for the human factors design basis of the CVDF.

  19. Human factors review for Severe Accident Sequence Analysis (SASA)

    SciTech Connect (OSTI)

    Krois, P.A.; Haas, P.M.; Manning, J.J.; Bovell, C.R.

    1984-01-01

    The paper will discuss work being conducted during this human factors review including: (1) support of the Severe Accident Sequence Analysis (SASA) Program based on an assessment of operator actions, and (2) development of a descriptive model of operator severe accident management. Research by SASA analysts on the Browns Ferry Unit One (BF1) anticipated transient without scram (ATWS) was supported through a concurrent assessment of operator performance to demonstrate contributions to SASA analyses from human factors data and methods. A descriptive model was developed called the Function Oriented Accident Management (FOAM) model, which serves as a structure for bridging human factors, operations, and engineering expertise and which is useful for identifying needs/deficiencies in the area of accident management. The assessment of human factors issues related to ATWS required extensive coordination with SASA analysts. The analysis was consolidated primarily to six operator actions identified in the Emergency Procedure Guidelines (EPGs) as being the most critical to the accident sequence. These actions were assessed through simulator exercises, qualitative reviews, and quantitative human reliability analyses. The FOAM descriptive model assumes as a starting point that multiple operator/system failures exceed the scope of procedures and necessitates a knowledge-based emergency response by the operators. The FOAM model provides a functionally-oriented structure for assembling human factors, operations, and engineering data and expertise into operator guidance for unconventional emergency responses to mitigate severe accident progression and avoid/minimize core degradation. Operators must also respond to potential radiological release beyond plant protective barriers. Research needs in accident management and potential uses of the FOAM model are described. 11 references, 1 figure.

  20. Human Factors Related to a Virtual Reality Surgical Simulator: The

    E-Print Network [OSTI]

    Bowden, Richard

    and therefore, reductions in patient intervention costs (Banta, 1993). #12; Human Factors Related to a Virtual Training System in the light of feedback from surgeons. Initial work to produce finite element models are displayed. The training system has been well received by the surgeons and represents a new and potentially

  1. Human Factors Evaluation of Advanced Electric Power Grid Visualization Tools

    SciTech Connect (OSTI)

    Greitzer, Frank L.; Dauenhauer, Peter M.; Wierks, Tamara G.; Podmore, Robin

    2009-04-01

    This report describes initial human factors evaluation of four visualization tools (Graphical Contingency Analysis, Force Directed Graphs, Phasor State Estimator and Mode Meter/ Mode Shapes) developed by PNNL, and proposed test plans that may be implemented to evaluate their utility in scenario-based experiments.

  2. Cognitive Engineering and Decision Making: An Overview and Future Course

    E-Print Network [OSTI]

    Kaber, David B.

    within the Human Factors and Ergonomics Society. Work that falls into this area of research and study practicing human factors/ergonomics to exceed the boundaries of specifying the human-machine inter- face and Decision Making, Volume 1, Number 1, Spring 2007, pp. 1­21 ©2007 Human Factors and Ergonomics Society. All

  3. A model of human collective decision-making in complex environments

    E-Print Network [OSTI]

    Carbone, Giuseppe

    2015-01-01

    A continuous-time Markov process is proposed to analyze how a group of humans solves a complex task, consisting in the search of the optimal set of decisions on a fitness landscape. Individuals change their opinions driven by two different forces: (i) the rational behavior which pushes them to change their opinions as to increase their own fitness values, and (ii) the social interactions which push individuals to reduce the diversity of their opinions in order to reach consensus. Results show that the performance of the group is strongly affected by the strength of social interactions and by the level of knowledge of the individuals. Increasing the strength of social interactions improves the performance of the team. However, too strong social interactions slow down the search of the optimal solution and worsen the performance of the group. We prove that a moderate level of knowledge is already enough to guarantee high performance of the group in making decisions.

  4. Examining the role of political entrepreneurship in the decision to change Mexico's foreign policy on human rights/

    E-Print Network [OSTI]

    Verdini Trejo, Bruno

    2013-01-01

    Under what circumstances can political entrepreneurs shape policy change? By relying upon the multiple streams framework, this research studies some of the factors that underpin decision-making in the public sector. Through ...

  5. Human Factors Considerations in New Nuclear Power Plants: Detailed Analysis.

    SciTech Connect (OSTI)

    OHara,J.; Higgins, J.; Brown, W.; Fink, R.

    2008-02-14

    This Nuclear Regulatory Commission (NRC) sponsored study has identified human-performance issues in new and advanced nuclear power plants. To identify the issues, current industry developments and trends were evaluated in the areas of reactor technology, instrumentation and control technology, human-system integration technology, and human factors engineering (HFE) methods and tools. The issues were organized into seven high-level HFE topic areas: Role of Personnel and Automation, Staffing and Training, Normal Operations Management, Disturbance and Emergency Management, Maintenance and Change Management, Plant Design and Construction, and HFE Methods and Tools. The issues where then prioritized into four categories using a 'Phenomena Identification and Ranking Table' methodology based on evaluations provided by 14 independent subject matter experts. The subject matter experts were knowledgeable in a variety of disciplines. Vendors, utilities, research organizations and regulators all participated. Twenty issues were categorized into the top priority category. This Brookhaven National Laboratory (BNL) technical report provides the detailed methodology, issue analysis, and results. A summary of the results of this study can be found in NUREG/CR-6947. The research performed for this project has identified a large number of human-performance issues for new control stations and new nuclear power plant designs. The information gathered in this project can serve as input to the development of a long-term strategy and plan for addressing human performance in these areas through regulatory research. Addressing human-performance issues will provide the technical basis from which regulatory review guidance can be developed to meet these challenges. The availability of this review guidance will help set clear expectations for how the NRC staff will evaluate new designs, reduce regulatory uncertainty, and provide a well-defined path to new nuclear power plant licensing.

  6. IMPROVING CONTROL ROOM DESIGN AND OPERATIONS BASED ON HUMAN FACTORS ANALYSES OR HOW MUCH HUMAN FACTORS UPGRADE IS ENOUGH ?

    SciTech Connect (OSTI)

    HIGGINS,J.C.; OHARA,J.M.; ALMEIDA,P.

    2002-09-19

    THE JOSE CABRERA NUCLEAR POWER PLANT IS A ONE LOOP WESTINGHOUSE PRESSURIZED WATER REACTOR. IN THE CONTROL ROOM, THE DISPLAYS AND CONTROLS USED BY OPERATORS FOR THE EMERGENCY OPERATING PROCEDURES ARE DISTRIBUTED ON FRONT AND BACK PANELS. THIS CONFIGURATION CONTRIBUTED TO RISK IN THE PROBABILISTIC SAFETY ASSESSMENT WHERE IMPORTANT OPERATOR ACTIONS ARE REQUIRED. THIS STUDY WAS UNDERTAKEN TO EVALUATE THE IMPACT OF THE DESIGN ON CREW PERFORMANCE AND PLANT SAFETY AND TO DEVELOP DESIGN IMPROVEMENTS.FIVE POTENTIAL EFFECTS WERE IDENTIFIED. THEN NUREG-0711 [1], PROGRAMMATIC, HUMAN FACTORS, ANALYSES WERE CONDUCTED TO SYSTEMATICALLY EVALUATE THE CR-LA YOUT TO DETERMINE IF THERE WAS EVIDENCE OF THE POTENTIAL EFFECTS. THESE ANALYSES INCLUDED OPERATING EXPERIENCE REVIEW, PSA REVIEW, TASK ANALYSES, AND WALKTHROUGH SIMULATIONS. BASED ON THE RESULTS OF THESE ANALYSES, A VARIETY OF CONTROL ROOM MODIFICATIONS WERE IDENTIFIED. FROM THE ALTERNATIVES, A SELECTION WAS MADE THAT PROVIDED A REASONABLEBALANCE BE TWEEN PERFORMANCE, RISK AND ECONOMICS, AND MODIFICATIONS WERE MADE TO THE PLANT.

  7. Applying Human Factors during the SIS Life Cycle

    SciTech Connect (OSTI)

    Avery, K.

    2010-05-05

    Safety Instrumented Systems (SIS) are widely used in U.S. Department of Energy's (DOE) nonreactor nuclear facilities for safety-critical applications. Although use of the SIS technology and computer-based digital controls, can improve performance and safety, it potentially introduces additional complexities, such as failure modes that are not readily detectable. Either automated actions or manual (operator) actions may be required to complete the safety instrumented function to place the process in a safe state or mitigate a hazard in response to an alarm or indication. DOE will issue a new standard, Application of Safety Instrumented Systems Used at DOE Nonreactor Nuclear Facilities, to provide guidance for the design, procurement, installation, testing, maintenance, operation, and quality assurance of SIS used in safety significant functions at DOE nonreactor nuclear facilities. The DOE standard focuses on utilizing the process industry consensus standard, American National Standards Institute/ International Society of Automation (ANSI/ISA) 84.00.01, Functional Safety: Safety Instrumented Systems for the Process Industry Sector, to support reliable SIS design throughout the DOE complex. SIS design must take into account human-machine interfaces and their limitations and follow good human factors engineering (HFE) practices. HFE encompasses many diverse areas (e.g., information display, user-system interaction, alarm management, operator response, control room design, and system maintainability), which affect all aspects of system development and modification. This paper presents how the HFE processes and principles apply throughout the SIS life cycle to support the design and use of SIS at DOE nonreactor nuclear facilities.

  8. An Integrated Suite of Tools to support Human Factors Engineering

    SciTech Connect (OSTI)

    Jacques V Hugo

    2001-08-01

    Human Factors Engineering (HFE) work for the nuclear industry imposes special demands on the practitioner in terms of the scope, complexity and safety requirements for humans in nuclear installations. Unfortunately HFE lags behind other engineering disciplines in the development and use of modern, powerful tools for the full range of analysis and design processes. HFE does not appear to be an attractive market for software and hardware developers and as a result, HFE practitioners usually have to rely on inefficient general-purpose tools like standard office software, or they have to use expensive special-purpose tools that offer only part of the solution they require and which also do not easily integrate with other tools. There have been attempts to develop generic software tools to support the HFE analyst and also to achieve some order and consistency in format and presentation. However, in spite of many years of development, very few tools have emerged that have achieved these goals. This would suggest the need for special tools, but existing commercial products have been found inadequate and to date not a single tool has been developed that adequately supports the special requirements of HFE work for the nuclear industry. This paper describes an integrated suite of generic as well as purpose-built tools that facilitate information solicitation, issues tracking, work domain analysis, functional requirements analysis, function allocation, operational sequence analysis, task analysis and development of HSI design requirements. In combination, this suite of tools supports the analytical as well as the representational aspects of key HFE activities primarily for new NPPs, including capturing information from subject matter experts and various source documents directly into the appropriate tool and then linking, analyzing and extending that information further to represent detailed functional and task information, and ultimately HSI design requirements. The paper also describes a tool developed especially for functional requirements analysis, function allocation, and task analysis.

  9. Epidermal growth factor and its receptors in human pancreatic carcinoma

    SciTech Connect (OSTI)

    Chen, Y.F.; Pan, G.Z.; Hou, X.; Liu, T.H.; Chen, J.; Yanaihara, C.; Yanaihara, N. (Peking Union Medical College Hospital, Beijing (China))

    1990-05-01

    The role of epidermal growth factor (EGF) in oncogenesis and progression of malignant tumors is a subject of vast interest. In this study, radioimmunoassay and radioreceptor assay of EGF were established. EGF contents in malignant and benign pancreatic tumors, in normal pancreas tissue, and in culture media of a human pancreatic carcinoma cell line were determined. EGF receptor binding studies were performed. It was shown that EGF contents in pancreatic carcinomas were significantly higher than those in normal pancreas or benign pancreatic tumors. EGF was also detected in the culture medium of a pancreatic carcinoma cell line. The binding of 125I-EGF to the pancreatic carcinoma cells was time and temperature dependent, reversible, competitive, and specific. Scatchard analysis showed that the dissociation constant of EGF receptor was 2.1 X 10(-9) M, number of binding sites was 1.3 X 10(5) cell. These results indicate that there is an over-expression of EGF/EGF receptors in pancreatic carcinomas, and that an autocrine regulatory mechanism may exist in the growth-promoting effect of EGF on tumor cells.

  10. Modeling and analysis of dynamic decision making in sequential two-choice tasks

    E-Print Network [OSTI]

    is calculated, and thus needs to explore through a series of A and B using rewards as feedback. In this type is related to human factors such as personality. Human decision making in sequential two-choice tasks has

  11. Preferences play a significant role in human decision making, partic-ularly as they relate to deciding how to act. As such, it comes as no sur-

    E-Print Network [OSTI]

    McIlraith, Sheila

    Preferences play a significant role in human decision making, partic- ularly as they relate, but the problem specification provides no addi- tional criteria to distinguish between good and bad plans

  12. SUBMITTED TO IEEE TRANSACTIONS ON POWER SYSTEMS, FEBRUARY 2002 1 Human Factors Aspects of Power System

    E-Print Network [OSTI]

    SUBMITTED TO IEEE TRANSACTIONS ON POWER SYSTEMS, FEBRUARY 2002 1 Human Factors Aspects of Power with human factors aspects of utilizing color contours to visualize electric power system bus voltage in the quickest solution times. Testing was done using a modified version of the IEEE 118 bus system. Index Terms--Power

  13. Accident analysis and hazard analysis for human and organizational factors

    E-Print Network [OSTI]

    Stringfellow, Margaret Virgina

    2011-01-01

    Pressures and incentives to operate complex socio-technical aerospace systems in a high-risk state are ever present. Without consideration of the role humans and organizations play in system safety during the development ...

  14. A Human Factors Perspective on Alarm System Research and Development 2000 to 2010

    SciTech Connect (OSTI)

    Curt Braun; John Grimes; Eric Shaver; Ronald Boring

    2011-09-01

    By definition, alarms serve to notify human operators of out-of-parameter conditions that could threaten equipment, the environment, product quality and, of course, human life. Given the complexities of industrial systems, human machine interfaces, and the human operator, the understanding of how alarms and humans can best work together to prevent disaster is continually developing. This review examines advances in alarm research and development from 2000 to 2010 and includes the writings of trade professionals, engineering and human factors researchers, and standards organizations with the goal of documenting advances in alarms system design, research, and implementation.

  15. Organizational Behavior and Human Decision Processes Vol. 87, No. 2, March, pp. 253277, 2002

    E-Print Network [OSTI]

    Chen, Zhongping

    of consequences on multiple dimensions. For example, decisions to clean up nuclear waste determine health to the traditional This work is funded under EPA Grant R826611-01-0 to UC Irvine under Principal Investigator L and environmental consequences over many decades and require the allocation of funds over a long period of time

  16. 254 PROCEEDINGS of the HUMAN FACTORS AND ERGONOMICS SOCIETY 42nd ANNUAL MEETING-1998 CONTENDING WITH COMPLEXITY: THE DEVELOPMENT AND

    E-Print Network [OSTI]

    Gray, Wayne

    254 PROCEEDINGS of the HUMAN FACTORS AND ERGONOMICS SOCIETY 42nd ANNUAL MEETING-1998 CONTENDING methodological and practical constraints. #12;PROCEEDINGS of the HUMAN FACTORS AND ERGONOMICS SOCIETY 42nd ANNUAL

  17. Human Factors and Ergonomics in Manufacturing, Vol. 19 (6) 601621 (2009) C 2009 Wiley Periodicals, Inc.

    E-Print Network [OSTI]

    Kaber, David B.

    2009-01-01

    Human Factors and Ergonomics in Manufacturing, Vol. 19 (6) 601­621 (2009) C 2009 Wiley Periodicals. Correspondence to: David Kaber, The Ergonomics Laboratory, Edward P. Fitts Department of Industrial & Systems

  18. Shinn-Cunningham, BG (2002). "Spatial auditory displays," to appear in International Encyclopedia of Ergonomics and Human Factors, 2nd

    E-Print Network [OSTI]

    Shinn-Cunningham, Barbara

    2002-01-01

    of Ergonomics and Human Factors, 2nd edition, W. Karwowski, Ed. London: Taylor and Francis, Ltd. Spatial

  19. Effect of mechanical factors on the function of engineered human blood microvessels in microfluidic collagen gels

    E-Print Network [OSTI]

    Tien, Joe

    Effect of mechanical factors on the function of engineered human blood microvessels in microfluidic the barrier function and stability of engineered human microvessels in microfluidic type I collagen gels in microfluidic collagen gels. Ó 2010 Elsevier Ltd. All rights reserved. 1. Introduction Early studies

  20. Human Factors Engineering Analysis Tool - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHigh energyHighlandWorkshop-SummerHow is theHughHuman

  1. Discovering functional transcription-factor combinations in the human cell cycle

    E-Print Network [OSTI]

    Church, George M.

    Discovering functional transcription-factor combinations in the human cell cycle Zhou Zhu,1 Jay-factor (TF) combinations using phylogenetically conserved sequences and microarray-based expression data of binding sites in the vicinity of one another and whether these combinations result in more coherent

  2. Human-Automation Collaboration in Complex Multivariate Resource Allocation Decision Support Systems

    E-Print Network [OSTI]

    Cummings, M.L.

    2010-01-01

    In resource allocation problems for systems with moving planning horizons and significant uncertainty, typical of supervisory control environments, it is critical that some balance of human-automation collaboration be ...

  3. Technology and architecture : informing investment decisions for the future of human space exploration

    E-Print Network [OSTI]

    Battat, Jonathan Alexander

    2012-01-01

    NASA's detailed programmatic goals, system architectures, and mission designs for future human spaceflight beyond Earth orbit remain unspecified. Given this uncertainty, it is not clear exactly which technologies are ...

  4. 1. " The impact of personal and organizational factors on the use of decision support systems by the Jordanian corporations in

    E-Print Network [OSTI]

    of marketing managers in Jordan corporations enrolled in Amman Stock Exchange. A random sample has been in marketing decision - taking at the Jordan corporations with high level. 2- There were no significant the usage level of DSS when taking the marketing decisions. The study recommended the necessity

  5. Human-automation interaction for lunar landing aimpoint redesignation

    E-Print Network [OSTI]

    Needham, Jennifer M

    2008-01-01

    Human-automation interactions are a critical area of research in systems with modem automation. The decision-making portion of tasks presents a special challenge for human-automation interactions because of the many factors ...

  6. HUMAN ERROR QUANTIFICATION USING PERFORMANCE SHAPING FACTORS IN THE SPAR-H METHOD

    SciTech Connect (OSTI)

    Harold S. Blackman; David I. Gertman; Ronald L. Boring

    2008-09-01

    This paper describes a cognitively based human reliability analysis (HRA) quantification technique for estimating the human error probabilities (HEPs) associated with operator and crew actions at nuclear power plants. The method described here, Standardized Plant Analysis Risk-Human Reliability Analysis (SPAR-H) method, was developed to aid in characterizing and quantifying human performance at nuclear power plants. The intent was to develop a defensible method that would consider all factors that may influence performance. In the SPAR-H approach, calculation of HEP rates is especially straightforward, starting with pre-defined nominal error rates for cognitive vs. action-oriented tasks, and incorporating performance shaping factor multipliers upon those nominal error rates.

  7. The Measure of Human Error: Direct and Indirect Performance Shaping Factors

    SciTech Connect (OSTI)

    Ronald L. Boring; Candice D. Griffith; Jeffrey C. Joe

    2007-08-01

    The goal of performance shaping factors (PSFs) is to provide measures to account for human performance. PSFs fall into two categories—direct and indirect measures of human performance. While some PSFs such as “time to complete a task” are directly measurable, other PSFs, such as “fitness for duty,” can only be measured indirectly through other measures and PSFs, such as through fatigue measures. This paper explores the role of direct and indirect measures in human reliability analysis (HRA) and the implications that measurement theory has on analyses and applications using PSFs. The paper concludes with suggestions for maximizing the reliability and validity of PSFs.

  8. What can I do with an engineering degree? What is human factors engineering? These

    E-Print Network [OSTI]

    Beex, A. A. "Louis"

    a couple of the questions asked by the Montgomery County, Va., High School/High Tech (HSHT) students Schools. February 28, 2007 HIGH SCHOOL/HIGH TECH STUDENTS VISIT CAMPUS A GUIDE FOR OUR JOURNEY TOWARD on a recent tour of the Human Factors Engineering and Ergonomics Center (HFEEC) at Virginia Tech. HSHT

  9. Human Factors Engineering and Ergonomics Analysis for the Canister Storage Building (CSB) Results and Findings

    SciTech Connect (OSTI)

    GARVIN, L.J.

    1999-09-20

    The purpose for this supplemental report is to follow-up and update the information in SNF-3907, Human Factors Engineering (HFE) Analysis: Results and Findings. This supplemental report responds to applicable U.S. Department of Energy Safety Analysis Report review team comments and questions. This Human Factors Engineering and Ergonomics (HFE/Erg) analysis was conducted from April 1999 to July 1999; SNF-3907 was based on analyses accomplished in October 1998. The HFE/Erg findings presented in this report and SNF-3907, along with the results of HNF-3553, Spent Nuclear Fuel Project, Final Safety Analysis Report, Annex A, ''Canister Storage Building Final Safety Analysis Report,'' Chapter A3.0, ''Hazards and Accidents Analyses,'' provide the technical basis for preparing or updating HNF-3553. Annex A, Chaptex A13.0, ''Human Factors Engineering.'' The findings presented in this report allow the HNF-3553 Chapter 13.0, ''Human Factors,'' to respond fully to the HFE requirements established in DOE Order 5480.23, Nuclear Safety Analysis Reports.

  10. In The Proceedings of the 46th Annual Meeting of the Human Factors & Ergonomics Society

    E-Print Network [OSTI]

    Gray, Wayne

    In The Proceedings of the 46th Annual Meeting of the Human Factors & Ergonomics Society-ecological approach to evaluate the effectiveness of alternative strategies interacting with slightly different, and action. The strategies we evaluate affect the target acquisition phase of the Argus Prime task. In our

  11. Industrial Application of Human Factors Safety Standards ISBN 978-82-471-2251-8 (Electronic)

    E-Print Network [OSTI]

    Langseth, Helge

    Industrial Application of Human Factors Safety Standards #12;ISBN 978-82-471-2251-8 (Electronic The main objective of this thesis is to investigate how selected standards are applied within an industrial. A survey of selected HSE standards used in the Norwegian petroleum industry revealed that the standards

  12. HEMATOPOIESIS Soluble factor cross-talk between human bone marrow-derived hematopoietic and

    E-Print Network [OSTI]

    Zandstra, Peter W.

    HEMATOPOIESIS Soluble factor cross-talk between human bone marrow-derived hematopoietic BM-derived progenitors and the balance between these compartments. Factorial experiments demonstrated45 ) and nonhematopoietic (CD45 ) cells, as well as their derivatives. Kinetic tracking of IL-3

  13. Human Factors Principles in Design of Computer-Mediated Visualization for Robot Missions

    SciTech Connect (OSTI)

    David I Gertman; David J Bruemmer

    2008-12-01

    With increased use of robots as a resource in missions supporting countermine, improvised explosive devices (IEDs), and chemical, biological, radiological nuclear and conventional explosives (CBRNE), fully understanding the best means by which to complement the human operator’s underlying perceptual and cognitive processes could not be more important. Consistent with control and display integration practices in many other high technology computer-supported applications, current robotic design practices rely highly upon static guidelines and design heuristics that reflect the expertise and experience of the individual designer. In order to use what we know about human factors (HF) to drive human robot interaction (HRI) design, this paper reviews underlying human perception and cognition principles and shows how they were applied to a threat detection domain.

  14. Applications of human factors engineering to LNG release prevention and control

    SciTech Connect (OSTI)

    Shikiar, R.; Rankin, W.L.; Rideout, T.B.

    1982-06-01

    The results of an investigation of human factors engineering and human reliability applications to LNG release prevention and control are reported. The report includes a discussion of possible human error contributions to previous LNG accidents and incidents, and a discussion of generic HF considerations for peakshaving plants. More specific recommendations for improving HF practices at peakshaving plants are offered based on visits to six facilities. The HF aspects of the recently promulgated DOT regulations are reviewed, and recommendations are made concerning how these regulations can be implemented utilizing standard HF practices. Finally, the integration of HF considerations into overall system safety is illustrated by a presentation of human error probabilities applicable to LNG operations and by an expanded fault tree analysis which explicitly recognizes man-machine interfaces.

  15. Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors

    SciTech Connect (OSTI)

    Erez, Neta; Glanz, Sarah; Raz, Yael; Department of Obstetrics and Gynecology, LIS Maternity Hospital, Tel Aviv Sourasky Medical Center, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv ; Avivi, Camilla; Barshack, Iris; Department of Pathology, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv

    2013-08-02

    Highlights: •CAFs in human breast and ovarian tumors express pro-inflammatory factors. •Expression of pro-inflammatory factors correlates with tumor invasiveness. •Expression of pro-inflammatory factors is associated with NF-?b activation in CAFs. -- Abstract: Inflammation has been established in recent years as a hallmark of cancer. Cancer Associated Fibroblasts (CAFs) support tumorigenesis by stimulating angiogenesis, cancer cell proliferation and invasion. We previously demonstrated that CAFs also mediate tumor-enhancing inflammation in a mouse model of skin carcinoma. Breast and ovarian carcinomas are amongst the leading causes of cancer-related mortality in women and cancer-related inflammation is linked with both these tumor types. However, the role of CAFs in mediating inflammation in these malignancies remains obscure. Here we show that CAFs in human breast and ovarian tumors express high levels of the pro-inflammatory factors IL-6, COX-2 and CXCL1, previously identified to be part of a CAF pro-inflammatory gene signature. Moreover, we show that both pro-inflammatory signaling by CAFs and leukocyte infiltration of tumors are enhanced in invasive ductal carcinoma as compared with ductal carcinoma in situ. The pro-inflammatory genes expressed by CAFs are known NF-?B targets and we show that NF-?B is up-regulated in breast and ovarian CAFs. Our data imply that CAFs mediate tumor-promoting inflammation in human breast and ovarian tumors and thus may be an attractive target for stromal-directed therapeutics.

  16. Human factors evaluation of remote afterloading brachytherapy. Volume 2, Function and task analysis

    SciTech Connect (OSTI)

    Callan, J.R.; Gwynne, J.W. III; Kelly, T.T.; Muckler, F.A. [Pacific Science and Engineering Group, San Diego, CA (United States); Saunders, W.M.; Lepage, R.P.; Chin, E. [University of California San Diego Medical Center, CA (United States). Div. of Radiation Oncology; Schoenfeld, I.; Serig, D.I. [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Systems Technology

    1995-05-01

    A human factors project on the use of nuclear by-product material to treat cancer using remotely operated afterloaders was undertaken by the Nuclear Regulatory Commission. The purpose of the project was to identify factors that contribute to human error in the system for remote afterloading brachytherapy (RAB). This report documents the findings from the first phase of the project, which involved an extensive function and task analysis of RAB. This analysis identified the functions and tasks in RAB, made preliminary estimates of the likelihood of human error in each task, and determined the skills needed to perform each RAB task. The findings of the function and task analysis served as the foundation for the remainder of the project, which evaluated four major aspects of the RAB system linked to human error: human-system interfaces; procedures and practices; training and qualifications of RAB staff; and organizational practices and policies. At its completion, the project identified and prioritized areas for recommended NRC and industry attention based on all of the evaluations and analyses.

  17. Transcription factor co-localization patterns affect human cell type-specific gene expression.

    E-Print Network [OSTI]

    Wang, Dennis; Rendon, Augusto; Ouwehand, Willem; Wernisch, Lorenz

    2012-06-21

    Wang et al. BMC Genomics 2012, 13:263 http://www.biomedcentral.com/1471-2164/13/263 RESEARCH ARTICLE Open Access Transcription factor co-localization patterns affect human cell type-specific gene expression Dennis Wang1*, Augusto Rendon2, Willem... identified thousands of regions along the *Correspondence: dennis.wang@mrc-bsu.cam.ac.uk 1MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, UK Full list of author information is available at the end of the article human genome where...

  18. Human Factors Aspects of Power System Voltage Visualizations Douglas A. Wiegmann Aaron M. Rich Thomas J. Overbye Yan Sun

    E-Print Network [OSTI]

    Human Factors Aspects of Power System Voltage Visualizations Douglas A. Wiegmann Aaron M. Rich with the human factors aspects of using color contours to visualize electric power system bus voltage magnitude in need of new research is the visualization of electric power system operation and analysis information

  19. The aesthetic and the ethic dimensions of human factors and Department of Industrial and Operations Engineering, University of Michigan,

    E-Print Network [OSTI]

    Liu, Yili

    Keywords: Engineering aesthetics; Ergo-aesthetic design; Ethics; Human factors and ergonomics; System, human factors and ergonomics has long established its goals of enhancing the safety, comfort@umich.edu Ergonomics ISSN 0014-0139 print/ISSN 1366-5847 online # 2003 Taylor & Francis Ltd http

  20. Human factors design guidelines for maintainability of Department of Energy nuclear facilities

    SciTech Connect (OSTI)

    Bongarra, J.P. Jr.; VanCott, H.P.; Pain, R.F.; Peterson, L.R.; Wallace, R.I.

    1985-06-18

    Intent of these guidelines is to provide design and design review teams of DOE nuclear facilities with human factors principles to enhance the design and aid in the inspection of DOE nuclear facilities, systems, and equipment. These guidelines are concerned with design features of DOE nuclear facilities which can potentially affect preventive and corrective maintenance of systems within DOE nuclear facilities. Maintenance includes inspecting, checking, troubleshooting, adjusting, replacing, repairing, and servicing activities. Other factors which influence maintainability such as repair and maintenance suport facilities, maintenance information, and various aspects of the environment are also addressed.

  1. A Framework for Geometric Reasoning About Human Figures and Factors in Assembly Processes

    SciTech Connect (OSTI)

    Calton, Terri L.

    1999-07-20

    Automatic assembly sequencing and visualization tools are valuable in determining the best assembly sequences, but without Human Factors and Figure Models (HFFMs) it is difficult to evaluate or visualize human interaction. In industry, accelerating technological advances and shorter market windows have forced companies to turn to an agile manufacturing paradigm. This trend has promoted computerized automation of product design and manufacturing processes, such as automated assembly planning. However, all automated assembly planning software tools assume that the individual components fly into their assembled configuration and generate what appear to be perfectly valid operations, but in reality some operations cannot physically be carried out by a human. For example, the use of a ratchet may be reasoned feasible for an assembly operation; however, when a hand is placed on the tool the operation is no longer feasible, perhaps because of inaccessibility, insufficient strength or human interference with assembly components. Similarly, human figure modeling algorithms may indicate that assembly operations are not feasible and consequently force design modifications, however, if they had the capability to quickly generate alternative assembly sequences, they might have identified a feasible solution. To solve this problem, HFFMs must be integrated with automated assembly planning which allows engineers to quickly verify that assembly operations are possible and to see ways to make the designs even better. This paper presents a framework for integrating geometry-based assembly planning algorithms with commercially available human figure modeling software packages. Experimental results to selected applications along with lessons learned are presented.

  2. Comfort and human factors in office and residential settings. (Latest citations from the NTIS data base). Published Search

    SciTech Connect (OSTI)

    Not Available

    1992-04-01

    The bibliography contains citations concerning human factors engineering, anthropometry, and ergonomics as they relate to human comfort in the office and home. Human requirements, including ventilation, temperature control, and lighting, are considered. Research regarding environmental architecture, and engineering, safety, and convenience aspects are discussed. (Contains a minimum of 142 citations and includes a subject term index and title list.)

  3. A human factors evaluation of computer keyboard interface devices for use by quadriplegics 

    E-Print Network [OSTI]

    Fleischer, Lawrence Blair

    1989-01-01

    for the degree of MASTER OF SCIENCE May 1989 Major Subject: Industrial Engineering A HUMAN FACTORS EVALUATION OF COMPUTER KEYBOARD INTERFACE DEVICES FOR USE BY QUADRIPLEGICS A Thesis by LAWRENCE BLAIR FLEISCHER Approved as to style and content by... such as Morse Code makes this system very usable. Freewheel, another type of head movement device, is produce by Pointer Systems and available for use on IBM and compatible personal computers. Infrared light is transmitted from a box placed on top...

  4. Identification and Evaluation of Human Factors Issues Associated with Emerging Nuclear Plant Technology

    SciTech Connect (OSTI)

    O'Hara,J.M.; Higgins,J.; Brown, William S.

    2009-04-01

    This study has identified human performance research issues associated with the implementation of new technology in nuclear power plants (NPPs). To identify the research issues, current industry developments and trends were evaluated in the areas of reactor technology, instrumentation and control technology, human-system integration technology, and human factors engineering (HFE) methods and tools. The issues were prioritized into four categories based on evaluations provided by 14 independent subject matter experts representing vendors, utilities, research organizations and regulators. Twenty issues were categorized into the top priority category. The study also identifies the priority of each issue and the rationale for those in the top priority category. The top priority issues were then organized into research program areas of: New Concepts of Operation using Multi-agent Teams, Human-system Interface Design, Complexity Issues in Advanced Systems, Operating Experience of New and Modernized Plants, and HFE Methods and Tools. The results can serve as input to the development of a long-term strategy and plan for addressing human performance in these areas to support the safe operation of new NPPs.

  5. Human factors evaluation of remote afterloading brachytherapy: Human error and critical tasks in remote afterloading brachytherapy and approaches for improved system performance. Volume 1

    SciTech Connect (OSTI)

    Callan, J.R.; Kelly, R.T.; Quinn, M.L. [Pacific Science and Engineering Group, San Diego, CA (United States)] [and others

    1995-05-01

    Remote Afterloading Brachytherapy (RAB) is a medical process used in the treatment of cancer. RAB uses a computer-controlled device to remotely insert and remove radioactive sources close to a target (or tumor) in the body. Some RAB problems affecting the radiation dose to the patient have been reported and attributed to human error. To determine the root cause of human error in the RAB system, a human factors team visited 23 RAB treatment sites in the US The team observed RAB treatment planning and delivery, interviewed RAB personnel, and performed walk-throughs, during which staff demonstrated the procedures and practices used in performing RAB tasks. Factors leading to human error in the RAB system were identified. The impact of those factors on the performance of RAB was then evaluated and prioritized in terms of safety significance. Finally, the project identified and evaluated alternative approaches for resolving the safety significant problems related to human error.

  6. NRC Reviewer Aid for Evaluating the Human Factors Engineering Aspects of Small Modular Reactors

    SciTech Connect (OSTI)

    OHara J. M.; Higgins, J.C.

    2012-01-13

    Small modular reactors (SMRs) are a promising approach to meeting future energy needs. Although the electrical output of an individual SMR is relatively small compared to that of typical commercial nuclear plants, they can be grouped to produce as much energy as a utility demands. Furthermore, SMRs can be used for other purposes, such as producing hydrogen and generating process heat. The design characteristics of many SMRs differ from those of current conventional plants and may require a distinct concept of operations (ConOps). The U.S. Nuclear Regulatory Commission (NRC) conducted research to examine the human factors engineering (HFE) and the operational aspects of SMRs. The research identified thirty potential human-performance issues that should be considered in the NRC's reviews of SMR designs and in future research activities. The purpose of this report is to support NRC HFE reviewers of SMR applications by identifying some of the questions that can be asked of applicants whose designs have characteristics identified in the issues. The questions for each issue were identified and organized based on the review elements and guidance contained in Chapter 18 of the Standard Review Plan (NUREG-0800), and the Human Factors Engineering Program Review Model (NUREG-0711).

  7. How Many Performance Shaping Factors are Necessary for Human Reliability Analysis?

    SciTech Connect (OSTI)

    Ronald L. Boring

    2010-06-01

    It has been argued that human reliability analysis (HRA) has expended considerable energy on creating detailed representations of human performance through an increasingly long list of performance shaping factors (PSFs). It is not clear, however, to what extent this refinement and expansion of PSFs has enhanced the quality of HRA. Indeed, there is considerable range in the number of PSFs provided by individual HRA methods, ranging from single factor models such as time-reliability curves, up to 50 or more PSFs in some current HRA models. The US Nuclear Regulatory Commission advocates 15 PSFs in its HRA Good Practices (NUREG-1792), while its SPAR-H method (NUREG/CR-6883) espouses the use of eight PSFs and its ATHEANA method (NUREG-1624) features an open-ended number of PSFs. The apparent differences in the optimal number of PSFs can be explained in terms of the diverse functions of PSFs in HRA. The purpose of this paper is to explore the role of PSFs across different stages of HRA, including identification of potential human errors, modeling of these errors into an overall probabilistic risk assessment, quantifying errors, and preventing errors.

  8. Factors Affecting Parents' Decisions to Treat Their Children with Autism Spectrum Disorder with Complementary and Alternative Treatments 

    E-Print Network [OSTI]

    Hall, Sarah Elizabeth

    2012-10-19

    Autism affects approximately one in 110 children in the United States. Many parents choose to treat their children with autism spectrum disorder (ASD) with complementary and alternative (CAM) treatments. In this study, factors that contribute...

  9. Applying Human Factors Evaluation and Design Guidance to a Nuclear Power Plant Digital Control System

    SciTech Connect (OSTI)

    Thomas Ulrich; Ronald Boring; William Phoenix; Emily Dehority; Tim Whiting; Jonathan Morrell; Rhett Backstrom

    2012-08-01

    The United States (U.S.) nuclear industry, like similar process control industries, has moved toward upgrading its control rooms. The upgraded control rooms typically feature digital control system (DCS) displays embedded in the panels. These displays gather information from the system and represent that information on a single display surface. In this manner, the DCS combines many previously separate analog indicators and controls into a single digital display, whereby the operators can toggle between multiple windows to monitor and control different aspects of the plant. The design of the DCS depends on the function of the system it monitors, but revolves around presenting the information most germane to an operator at any point in time. DCSs require a carefully designed human system interface. This report centers on redesigning existing DCS displays for an example chemical volume control system (CVCS) at a U.S. nuclear power plant. The crucial nature of the CVCS, which controls coolant levels and boration in the primary system, requires a thorough human factors evaluation of its supporting DCS. The initial digital controls being developed for the DCSs tend to directly mimic the former analog controls. There are, however, unique operator interactions with a digital vs. analog interface, and the differences have not always been carefully factored in the translation of an analog interface to a replacement DCS. To ensure safety, efficiency, and usability of the emerging DCSs, a human factors usability evaluation was conducted on a CVCS DCS currently being used and refined at an existing U.S. nuclear power plant. Subject matter experts from process control engineering, software development, and human factors evaluated the DCS displays to document potential usability issues and propose design recommendations. The evaluation yielded 167 potential usability issues with the DCS. These issues should not be considered operator performance problems but rather opportunities identified by experts to improve upon the design of the DCS. A set of nine design recommendations was developed to address these potential issues. The design principles addressed the following areas: (1) color, (2) pop-up window structure, (3) navigation, (4) alarms, (5) process control diagram, (6) gestalt grouping, (7) typography, (8) terminology, and (9) data entry. Visuals illustrating the improved DCS displays accompany the design recommendations. These nine design principles serve as the starting point to a planned general DCS style guide that can be used across the U.S. nuclear industry to aid in the future design of effective DCS interfaces.

  10. DEVELOPMENT OF HUMAN FACTORS ENGINEERING GUIDANCE FOR SAFETY EVALUATIONS OF ADVANCED REACTORS.

    SciTech Connect (OSTI)

    O'HARA, J.; PERSENSKY, J.; SZABO, A.

    2006-10-01

    Advanced reactors are expected to be based on a concept of operations that is different from what is currently used in today's reactors. Therefore, regulatory staff may need new tools, developed from the best available technical bases, to support licensing evaluations. The areas in which new review guidance may be needed and the efforts underway to address the needs will be discussed. Our preliminary results focus on some of the technical issues to be addressed in three areas for which new guidance may be developed: automation and control, operations under degraded conditions, and new human factors engineering methods and tools.

  11. PROCEEDINGS of the HUMAN FACTORS AND ERGONOMICS SOCIETY 42nd ANNUAL MEETING--IYYB SCALED WORLDS AS RESEARCH TOOLS: A

    E-Print Network [OSTI]

    Gray, Wayne

    PROCEEDINGS of the HUMAN FACTORS AND ERGONOMICS SOCIETY 42nd ANNUAL MEETING--IYYB 1157 SCALED and Ergonomics Society (pp. 163-167). Santa Monica, CA: HFES. ACKNOWLEDGEMENTS The work at George Mason

  12. Updating Human Factors Engineering Guidelines for Conducting Safety Reviews of Nuclear Power Plants

    SciTech Connect (OSTI)

    O, J.M.; Higgins, J.; Stephen Fleger - NRC

    2011-09-19

    The U.S. Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) programs of applicants for nuclear power plant construction permits, operating licenses, standard design certifications, and combined operating licenses. The purpose of these safety reviews is to help ensure that personnel performance and reliability are appropriately supported. Detailed design review procedures and guidance for the evaluations is provided in three key documents: the Standard Review Plan (NUREG-0800), the HFE Program Review Model (NUREG-0711), and the Human-System Interface Design Review Guidelines (NUREG-0700). These documents were last revised in 2007, 2004 and 2002, respectively. The NRC is committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool. To this end, the NRC is updating its guidance to stay current with recent research on human performance, advances in HFE methods and tools, and new technology being employed in plant and control room design. This paper describes the role of HFE guidelines in the safety review process and the content of the key HFE guidelines used. Then we will present the methodology used to develop HFE guidance and update these documents, and describe the current status of the update program.

  13. Human Factors Engineering Program Review Model (NUREG-0711)Revision 3: Update Methodology and Key Revisions

    SciTech Connect (OSTI)

    OHara J. M.; Higgins, J.; Fleger, S.

    2012-07-22

    The U.S. Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) programs of applicants for nuclear power plant construction permits, operating licenses, standard design certifications, and combined operating licenses. The purpose of these safety reviews is to help ensure that personnel performance and reliability are appropriately supported. Detailed design review procedures and guidance for the evaluations is provided in three key documents: the Standard Review Plan (NUREG-0800), the HFE Program Review Model (NUREG-0711), and the Human-System Interface Design Review Guidelines (NUREG-0700). These documents were last revised in 2007, 2004 and 2002, respectively. The NRC is committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool. To this end, the NRC is updating its guidance to stay current with recent research on human performance, advances in HFE methods and tools, and new technology being employed in plant and control room design. NUREG-0711 is the first document to be addressed. We present the methodology used to update NUREG-0711 and summarize the main changes made. Finally, we discuss the current status of the update program and the future plans.

  14. Decision insight into stakeholder conflict for ERN.

    SciTech Connect (OSTI)

    Siirola, John; Tidwell, Vincent Carroll; Benz, Zachary O.; Stansbury, Melanie; Richards, Elizabeth H.; Turnley, Jessica Glicken; Warrender, Christina E.; Morrow, James Dan

    2012-02-01

    Participatory modeling has become an important tool in facilitating resource decision making and dispute resolution. Approaches to modeling that are commonly used in this context often do not adequately account for important human factors. Current techniques provide insights into how certain human activities and variables affect resource outcomes; however, they do not directly simulate the complex variables that shape how, why, and under what conditions different human agents behave in ways that affect resources and human interactions related to them. Current approaches also do not adequately reveal how the effects of individual decisions scale up to have systemic level effects in complex resource systems. This lack of integration prevents the development of more robust models to support decision making and dispute resolution processes. Development of integrated tools is further hampered by the fact that collection of primary data for decision-making modeling is costly and time consuming. This project seeks to develop a new approach to resource modeling that incorporates both technical and behavioral modeling techniques into a single decision-making architecture. The modeling platform is enhanced by use of traditional and advanced processes and tools for expedited data capture. Specific objectives of the project are: (1) Develop a proof of concept for a new technical approach to resource modeling that combines the computational techniques of system dynamics and agent based modeling, (2) Develop an iterative, participatory modeling process supported with traditional and advance data capture techniques that may be utilized to facilitate decision making, dispute resolution, and collaborative learning processes, and (3) Examine potential applications of this technology and process. The development of this decision support architecture included both the engineering of the technology and the development of a participatory method to build and apply the technology. Stakeholder interaction with the model and associated data capture was facilitated through two very different modes of engagement, one a standard interface involving radio buttons, slider bars, graphs and plots, while the other utilized an immersive serious gaming interface. The decision support architecture developed through this project was piloted in the Middle Rio Grande Basin to examine how these tools might be utilized to promote enhanced understanding and decision-making in the context of complex water resource management issues. Potential applications of this architecture and its capacity to lead to enhanced understanding and decision-making was assessed through qualitative interviews with study participants who represented key stakeholders in the basin.

  15. Human factors aspects of the major upgrade to the control systems at the LANL plutonium facility

    SciTech Connect (OSTI)

    Higgins, J.C.; Pope, N.

    1997-04-01

    The Plutonium Facility (TA-55) at Los Alamos National Laboratory (LANL) has been in operation for almost 20 years. The Operations Center of TA-55 is the nerve center of the facility where operators are on duty around the clock and monitor several thousand data points using the Facility Control System (FCS). The FCS monitors, displays, alarms, and provides some limited control of several systems, including: HVAC, fire detection and suppression, radiation detection, and electrical. The FCS was failing and needed to be replaced expeditiously. This paper will discuss the human factors aspects of the design, installation, and testing of the new FCS within the above noted constraints. Particular items to be discussed include the functional requirements definition, operating experience review, screen designs, test program, operator training, and phased activation of the new circuits in an operational facility.

  16. Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution

    SciTech Connect (OSTI)

    Chen, Liqing Wang, Yujun; Wells, David; Toh, Diana; Harold, Hunt; Zhou, Jing; DiGiammarino, Enrico; Meehan, Edward J.

    2006-09-01

    The crystal structure of the SH3 domain of human osteoclast-stimulating factor has been determined and refined to the ultrahigh resolution of 1.07 Å. The structure at atomic resolution provides an accurate framework for structure-based design of its inhibitors. Osteoclast-stimulating factor (OSF) is an intracellular signaling protein, produced by osteoclasts themselves, that enhances osteoclast formation and bone resorption. It is thought to act via an Src-related signaling pathway and contains SH3 and ankyrin-repeat domains which are involved in protein–protein interactions. As part of a structure-based anti-bone-loss drug-design program, the atomic resolution X-ray structure of the recombinant human OSF SH3 domain (hOSF-SH3) has been determined. The domain, residues 12–72, yielded crystals that diffracted to the ultrahigh resolution of 1.07 Å. The overall structure shows a characteristic SH3 fold consisting of two perpendicular ?-sheets that form a ?-barrel. Structure-based sequence alignment reveals that the putative proline-rich peptide-binding site of hOSF-SH3 consists of (i) residues that are highly conserved in the SH3-domain family, including residues Tyr21, Phe23, Trp49, Pro62, Asn64 and Tyr65, and (ii) residues that are less conserved and/or even specific to hOSF, including Thr22, Arg26, Thr27, Glu30, Asp46, Thr47, Asn48 and Leu60, which might be key to designing specific inhibitors for hOSF to fight osteoporosis and related bone-loss diseases. There are a total of 13 well defined water molecules forming hydrogen bonds with the above residues in and around the peptide-binding pocket. Some of those water molecules might be important for drug-design approaches. The hOSF-SH3 structure at atomic resolution provides an accurate framework for structure-based design of its inhibitors.

  17. Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D

    SciTech Connect (OSTI)

    Forneris, Federico; Burnley, B. Tom; Gros, Piet, E-mail: p.gros@uu.nl [Utrecht University, Padualaan 8, 3584 CH Utrecht (Netherlands)

    2014-03-01

    Ensemble-refinement analysis of native and mutant factor D (FD) crystal structures indicates a dynamical transition in FD from a self-inhibited inactive conformation to a substrate-bound active conformation that is reminiscent of the allostery in thrombin. Comparison with previously observed dynamics in thrombin using NMR data supports the crystallographic ensembles. Human factor D (FD) is a self-inhibited thrombin-like serine proteinase that is critical for amplification of the complement immune response. FD is activated by its substrate through interactions outside the active site. The substrate-binding, or ‘exosite’, region displays a well defined and rigid conformation in FD. In contrast, remarkable flexibility is observed in thrombin and related proteinases, in which Na{sup +} and ligand binding is implied in allosteric regulation of enzymatic activity through protein dynamics. Here, ensemble refinement (ER) of FD and thrombin crystal structures is used to evaluate structure and dynamics simultaneously. A comparison with previously published NMR data for thrombin supports the ER analysis. The R202A FD variant has enhanced activity towards artificial peptides and simultaneously displays active and inactive conformations of the active site. ER revealed pronounced disorder in the exosite loops for this FD variant, reminiscent of thrombin in the absence of the stabilizing Na{sup +} ion. These data indicate that FD exhibits conformational dynamics like thrombin, but unlike in thrombin a mechanism has evolved in FD that locks the unbound native state into an ordered inactive conformation via the self-inhibitory loop. Thus, ensemble refinement of X-ray crystal structures may represent an approach alternative to spectroscopy to explore protein dynamics in atomic detail.

  18. Solution structure of human von Willebrand factor studied using small angle nuetron scattering

    SciTech Connect (OSTI)

    Singh, Indrajeet; Shankaran, Harish; Beauharnois, Mark E.; Xiao, Zhihua; Alexandridis, Paschalis; Neelamegham, Sriram

    2006-12-15

    Von Willebrand factor (vWF) binding to platelets under high fluid shear is an important step regulating atherothrombosis. We applied light and small-angle neutron scattering to study the solution structure of human vWF multimers and protomer. Results suggest that these proteins resemble prolate ellipsoids with radius of gyration (Rg) of ~75nm and ~30nm for multimer and protomer respectively. The ellipsoid dimensions/radii are 175×28nm for multimers and 70×9.1nm for protomers. Substructural repeat domains are evident within multimeric-vWF that are indicative of elements of the protomer quarternary structure (16nm) and individual functional domains (4.5nm). Amino acids occupy only ~2% volume of multimer and protomer ellipsoids, compared to other proteins like albumin (98%) and fibrinogen (35%). vWF treatment with Guanidine?HCl, which increases vWF susceptibility to proteolysis by ADAMTS-13, causes local structural changes at length scales<10nm without altering protein Rg. Treatment of multimer but not protomer-vWF with random homobifunctional linker BS3, prior to reduction of inter-monomer disulfide linkages and western blotting reveals a pattern of dimer and trimer units that indicate the presence of stable inter-monomer non-covalent interactions within the multimer. Overall, vWF solution structure is stabilized by non-covalent interactions between different monomer units. Local changes in multimer conformation are sufficient for ADAMTS-13 mediated proteolysis.

  19. Bayesian Inference of the Number of Factors in Gene-Expression Analysis: Application to Human Virus Challenge Studies

    E-Print Network [OSTI]

    Carin, Lawrence

    Bayesian Inference of the Number of Factors in Gene-Expression Analysis: Application to Human Virus. Ginsburg2 , Alfred Hero III3 , Joseph Lucas2 , David Dunson4 and Lawrence Carin1§ 1 Electrical and Computer University 3 Electrical & Computer Engineering Department, University of Michigan 4 Statistics Department

  20. Human Factors Analysis of Power System Visualizations Thomas J. Overbye Douglas A. Wiegmann Aaron M. Rich Yan Sun

    E-Print Network [OSTI]

    Human Factors Analysis of Power System Visualizations Thomas J. Overbye Douglas A. Wiegmann Aaron M testing the usability of different power system visualizations. In particular, the ability of participants to assess and correct power system voltage problems was tested. Participants were divided into three groups

  1. Published in: 1991 Proceedings of Human Factors in Computing Systems (CHI '91), New Orleans, April-May, 1991 Information Access

    E-Print Network [OSTI]

    Fischer, Gerhard

    newsgroups. CONCEPTUAL FRAMEWORK An Information Llfecycle Our work in developing systems that helpPublished in: 1991 Proceedings of Human Factors in Computing Systems (CHI '91), New Orleans, April-May, 1991 Information Access in Complex, Poorly Structured Information Spaces Gerhard Fischer & Curt Stevens

  2. Neth, H., Khemlani, S. S., Oppermann, B., & Gray, W. D. (2006). Juggling multiple tasks: A rational analysis of multitasking inn a synthetic task environment, Proceedings of the 50th annual meeting of the Human Factors and Ergonomics Society. San Francisc

    E-Print Network [OSTI]

    Gray, Wayne

    2006-01-01

    of the Human Factors and Ergonomics Society. San Francisco, CA: HFES. JUGGLING MULTIPLE TASKS: A RATIONAL

  3. Investigating online decision-making styles 

    E-Print Network [OSTI]

    Park, Young A

    2009-05-15

    As one of the factors influencing consumers purchase behavior, decision-making styles are crucial for understanding consumer shopping behavior and for developing successful marketing strategies. Decision-making styles have ...

  4. Financial Implications of Engineering Decisions 

    E-Print Network [OSTI]

    Aslan, Veysel

    2012-10-19

    planning and engineering decisions have detrimental effects on communities as they attempt to recover and rebuild. While there is an inherent difficulty in the quantification of the cost of human life, interruption in business operations, and damage...

  5. Effects of a High Oleic Acid Beef Diet on Cardiovascular Disease Risk Factors of Human Subjects 

    E-Print Network [OSTI]

    Adams, Thaddeus Hunter

    2012-10-19

    The consumption of high-fat hamburger enriched with saturated fatty acids (SFA) and trans-fatty acids (TFA) may increase risk factors for cardiovascular disease, whereas hamburger enriched with monounsaturated fatty acids ...

  6. Analysis of variation at transcription factor binding sites in Drosophila and humans

    E-Print Network [OSTI]

    Spivakov, Mikhail

    Background: Advances in sequencing technology have boosted population genomics and made it possible to map the positions of transcription factor binding sites (TFBSs) with high precision. Here we investigate TFBS variability ...

  7. Chromosomal mapping of the human and mouse homologues of two new members of the AP-2 family of transcription factors

    SciTech Connect (OSTI)

    Williamson, J.A.; Sheer, D. [ICRF, London (United Kingdom)] [ICRF, London (United Kingdom); Bosher, J.M. [Hammersmith Hospital, Longon (United Kingdom)] [and others] [Hammersmith Hospital, Longon (United Kingdom); and others

    1996-07-01

    The AP-2 transcription factor has been shown to play an important role in the development of tissues of ectodermal origin and has also been implicated in mammary oncogenesis. It has recently been found that AP-2 is encoded by a family of related genes, AP-2{alpha}, AP-2{beta}, and AP-2{gamma}. As a further step in understanding the role of each of these genes has in development, we have used fluorescence in situ hybridization to map the chromosomal locations of the mouse and human homologues of the newly isolated AP-2{beta} and AP-2{gamma} genes. Tcfap2b and Tcfap2c map to mouse chromosomes 1A2-4 and 2H3-4, respectively, while TFAP2B and TFAP2C map to human chromosomes 6p12 and 20q13.2, the later being a region that is frequently amplified in breast carcinoma. 20 refs., 1 fig., 1 tab.

  8. Human factors design, verification, and validation for two types of control room upgrades at a nuclear power plant

    SciTech Connect (OSTI)

    Boring, Laurids Ronald

    2014-10-01

    This paper describes the NUREG-0711 based human factors engineering (HFE) phases and associated elements required to support design, verification and validation (V&V), and implementation of a new plant process computer (PPC) and turbine control system (TCS) at a representative nuclear power plant. This paper reviews ways to take a human-system interface (HSI) specification and use it when migrating legacy PPC displays or designing displays with new functionality. These displays undergo iterative usability testing during the design phase and then undergo an integrated system validation (ISV) in a full scope control room training simulator. Following the successful demonstration of operator performance with the systems during the ISV, the new system is implemented at the plant, first in the training simulator and then in the main control room.

  9. Proceedings of the 5th International Conference on Applied Human Factors and Ergonomics AHFE 2014, Krakw, Poland 19-23 July 2014 Edited by T. Ahram, W. Karwowski and T. Marek

    E-Print Network [OSTI]

    Nijholt, Anton

    Proceedings of the 5th International Conference on Applied Human Factors and Ergonomics AHFE 2014 Human Factors and Ergonomics AHFE 2014, Kraków, Poland 19-23 July 2014 Edited by T. Ahram, W. Karwowski

  10. Original article Assessing the influence of environmental and human factors on native

    E-Print Network [OSTI]

    Rodríguez, Miguel Ángel

    Masson SAS. All rights reserved. 1. Introduction Understanding the ecological determinants of biological factors) (Callicott et al., 1999; Stohlgren et al., 2003; Davis et al., 2005; Richardson et al., 2005 (Stohlgren et al., 2003; Davis et al., 2005; Richardson et al., 2005; Thuiller et al., 2006). Among these

  11. Gray, W. D., Schoelles, M. J., Bringsjord, S. A., Burrows, K., & Colder, B. (2003). Sage: Five powerful ideas for studying and transforming the intellligence analyst's task environment, Human Factors and Ergonomics Society (pp. 1019-1023).

    E-Print Network [OSTI]

    Gray, Wayne

    2003-01-01

    and Ergonomics Society (pp. 1019-1023). Santa Monica, CA: Human Factors and Ergonomics Society. p. 1019 SAGE

  12. Human perceptual deficits as factors in computer interface test and evaluation

    SciTech Connect (OSTI)

    Bowser, S.E.

    1992-06-01

    Issues related to testing and evaluating human computer interfaces are usually based on the machine rather than on the human portion of the computer interface. Perceptual characteristics of the expected user are rarely investigated, and interface designers ignore known population perceptual limitations. For these reasons, environmental impacts on the equipment will more likely be defined than will user perceptual characteristics. The investigation of user population characteristics is most often directed toward intellectual abilities and anthropometry. This problem is compounded by the fact that some deficits capabilities tend to be found in higher-than-overall population distribution in some user groups. The test and evaluation community can address the issue from two primary aspects. First, assessing user characteristics should be extended to include tests of perceptual capability. Secondly, interface designs should use multimode information coding.

  13. Automated work packages architecture: An initial set of human factors and instrumentation and controls requirements

    SciTech Connect (OSTI)

    Agarwal, Vivek; Oxstrand, Johanna H.; Le Blanc, Katya L.

    2014-09-01

    The work management process in current fleets of national nuclear power plants is so highly dependent on large technical staffs and quality of work instruction, i.e., paper-based, that this puts nuclear energy at somewhat of a long-term economic disadvantage and increase the possibility of human errors. Technologies like mobile portable devices and computer-based procedures can play a key role in improving the plant work management process, thereby increasing productivity and decreasing cost. Automated work packages are a fundamentally an enabling technology for improving worker productivity and human performance in nuclear power plants work activities because virtually every plant work activity is accomplished using some form of a work package. As part of this year’s research effort, automated work packages architecture is identified and an initial set of requirements identified, that are essential and necessary for implementation of automated work packages in nuclear power plants.

  14. Human factors in E&P facility design, a participatory approach

    SciTech Connect (OSTI)

    Dekker, G.F.; Bergen, E.A. van den

    1996-11-01

    To ensure that ergonomics are taken into account in the conceptual design phases of engineering projects, NAM has introduced the {open_quote}Ergonomics in design{close_quote} workshop. This paper describes the general format, timing and techniques used in these workshops. An example of a case study is presented together with a cost benefit analysis. Finally, a concluding summary of the workshop success factors is given together with the areas for further improvement.

  15. Management decisions for cogeneration : a survey analysis

    E-Print Network [OSTI]

    Radcliffe, Robert R.

    1982-01-01

    This study explores the underlying factors in the decision by private, private non-profit, and public sector facility owners to invest in cogeneration technology. It employs alpha factor analysis techniques to develop ...

  16. Autism Genetic Testing: Psychological Factors Associated with the Test Decisions Among Parents of Children with Autism Spectrum Disorders (ASDs) in Taiwan 

    E-Print Network [OSTI]

    Xu, Lei

    2014-07-09

    Autism spectrum disorders (ASDs) are a group of highly inheritable disorders. Genetic testing for ASD is anticipated to be offered in Taiwan in the near future. Therefore, it is critical to explore the psychological factors regarding the test...

  17. "Adapting C2 to the 21st Century" Introducing a Human-Automation Collaboration Taxonomy (HACT) in Command and Control Decision-

    E-Print Network [OSTI]

    Cummings, Mary "Missy"

    1 12TH ICCRTS "Adapting C2 to the 21st Century" Introducing a Human-Automation Collaboration and Automation Laboratory 77 Massachusetts Avenue, Bldg 33-407 Cambridge, MA 02319 #12;2 Introducing a Human-Automation-support systems that attempt to facilitate collaboration between the human operator and automation. Unfortunately

  18. Effects of Adenovirus-Mediated Delivery of the Human Hepatocyte Growth Factor Gene in Experimental Radiation-Induced Heart Disease

    SciTech Connect (OSTI)

    Hu Shunying; Chen Yundai; Li Libing; Chen Jinlong; Wu Bin; Zhou, Xiao; Zhi Guang; Li Qingfang; Wang Rongliang; Duan Haifeng; Guo Zikuan; Yang Yuefeng; Xiao Fengjun; Wang Hua; Wang Lisheng

    2009-12-01

    Purpose: Irradiation to the heart may lead to late cardiovascular complications. The purpose of this study was to investigate whether adenovirus-mediated delivery of the human hepatocyte growth factor gene could reduce post-irradiation damage of the rat heart and improve heart function. Methods and Materials: Twenty rats received single-dose irradiation of 20 Gy gamma ray locally to the heart and were randomized into two groups. Two weeks after irradiation, these two groups of rats received Ad-HGF or mock adenovirus vector intramyocardial injection, respectively. Another 10 rats served as sham-irradiated controls. At post-irradiation Day 120, myocardial perfusion was tested by myocardial contrast echocardiography with contrast agent injected intravenously. At post-irradiation Day 180, cardiac function was assessed using the Langendorff technique with an isolated working heart model, after which heart samples were collected for histological evaluation. Results: Myocardial blood flow was significantly improved in HGF-treated animals as measured by myocardial contrast echocardiography at post-irradiation Day 120 . At post-irradiation Day 180, cardiac function was significantly improved in the HGF group compared with mock vector group, as measured by left ventricular peak systolic pressure (58.80 +- 9.01 vs. 41.94 +- 6.65 mm Hg, p < 0.05), the maximum dP/dt (5634 +- 1303 vs. 1667 +- 304 mm Hg/s, p < 0.01), and the minimum dP/dt (3477 +- 1084 vs. 1566 +- 499 mm Hg/s, p < 0.05). Picrosirius red staining analysis also revealed a significant reduction of fibrosis in the HGF group. Conclusion: Based on the study findings, hepatocyte growth factor gene transfer can attenuate radiation-induced cardiac injury and can preserve cardiac function.

  19. Feasibility of developing a portable driver performance data acquisition system for human factors research: Design specifications. Volume 3

    SciTech Connect (OSTI)

    Carter, R.J.; Barickman, F.S.

    1998-01-01

    A two-phase, multi-year research program entitled ``development of a portable driver performance data acquisition system for human factors research was recently completed. The primary objective of the project was to develop a portable data acquisition system for crash avoidance research (DASCAR) that will allow driver performance data to be collected using a large variety of vehicle types and that would be capable of being installed on a given vehicle type within a relatively short-time frame. During Phase 1 a feasibility study for designing and fabricating DASCAR was conducted. In phase 2 of the research DASCAR was actually developed and validated. This technical memorandum documents the results from the feasibility study. It is subdivided into three volumes. Volume one addresses the last five items in the phase 1 research and the first issue in the second phase of the project. Volume 2 presents the related appendices. Volume three (this report) displays the design specifications developed for DASCAR during the ``develop design requirements and specifications for a portable driver performance data acquisition system`` task. Design specifications were assembled for each DASCAR element. The specifications were prepared in sufficient detail to allow a third party to use them to design, develop, procure, and subsequently construct the data acquisition system. This report also covers the background to the program.

  20. Wiebe, E. N. (1994). Evaluation of alternative methods of representing three-dimensional 1 objects on computer displays. In, Proceedings of the Human Factors and Ergonomics Society

    E-Print Network [OSTI]

    1994-01-01

    Wiebe, E. N. (1994). Evaluation of alternative methods of representing three-dimensional 1 objects on computer displays. In, Proceedings of the Human Factors and Ergonomics Society 38th Annual Meeting, October 24-28, 1994. EVALUATION OF ALTERNATIVE METHODS OF REPRESENTING THREE- DIMENSIONAL OBJECTS ON COMPUTER

  1. PROCEEDINGS of the HUMAN FACTORS AND ERGONOMICS SOCIETY 45th ANNUAL MEETING-2001 THE EFFECT OF A STANDARDIZED DATA COLLECTION FORM ON THE

    E-Print Network [OSTI]

    Virginia, University of

    PROCEEDINGS of the HUMAN FACTORS AND ERGONOMICS SOCIETY 45th ANNUAL MEETING- 2001 THE EFFECT pain is frequently evaluated in an irregular and non-standard manner, even within individual aimed to relieve these problems Departments in the United States are evaluated is by developing

  2. CONTRIBUTION TO THE ACM CONFERENCE ON HUMAN FACTORS IN COMPUTING SYSTEMS (CHI '89) Topic Area: Interface Design Tools and Techniques (specifically: User Interface Tools Kits; Rapid

    E-Print Network [OSTI]

    Fischer, Gerhard

    CONTRIBUTION TO THE ACM CONFERENCE ON HUMAN FACTORS IN COMPUTING SYSTEMS (CHI '89) Topic Area Science University of Colorado, Boulder, Colorado 80309 Abstract Design Environments are computer systems environments in the form of computer systems supporting cooperative problem solving between designer

  3. The Hidden Human Factors in Unmanned Aerial Vehicles Chris. W. Johnson, DPhil; Department of Computing Science, University of Glasgow, Scotland, UK.

    E-Print Network [OSTI]

    Johnson, Chris

    The Hidden Human Factors in Unmanned Aerial Vehicles Chris. W. Johnson, DPhil; Department In April 2006, an Unmanned Aerial Vehicle crashed near Nogales, Arizona. This incident is of interest Unmanned Aerial Vehicles (UAVs) refers to the airborne component of the wider Unmanned Aircraft Systems

  4. First Evaluation of the Biologic Effectiveness Factors of Boron Neutron Capture Therapy (BNCT) in a Human Colon Carcinoma Cell Line

    SciTech Connect (OSTI)

    Dagrosa, Maria Alejandra; Crivello, Martin; Perona, Marina; Thorp, Silvia; Santa Cruz, Gustavo Alberto; Pozzi, Emiliano; Casal, Mariana; Thomasz, Lisa; Cabrini, Romulo; Kahl, Steven; Juvenal, Guillermo Juan; Pisarev, Mario Alberto

    2011-01-01

    Purpose: DNA lesions produced by boron neutron capture therapy (BNCT) and those produced by gamma radiation in a colon carcinoma cell line were analyzed. We have also derived the relative biologic effectiveness factor (RBE) of the neutron beam of the RA-3- Argentine nuclear reactor, and the compound biologic effectiveness (CBE) values for p-boronophenylalanine ({sup 10}BPA) and for 2,4-bis ({alpha},{beta}-dihydroxyethyl)-deutero-porphyrin IX ({sup 10}BOPP). Methods and Materials: Exponentially growing human colon carcinoma cells (ARO81-1) were distributed into the following groups: (1) BPA (10 ppm {sup 10}B) + neutrons, (2) BOPP (10 ppm {sup 10}B) + neutrons, (3) neutrons alone, and (4) gamma rays ({sup 60}Co source at 1 Gy/min dose-rate). Different irradiation times were used to obtain total absorbed doses between 0.3 and 5 Gy ({+-}10%) (thermal neutrons flux = 7.5 10{sup 9} n/cm{sup 2} sec). Results: The frequency of micronucleated binucleated cells and the number of micronuclei per micronucleated binucleated cells showed a dose-dependent increase until approximately 2 Gy. The response to gamma rays was significantly lower than the response to the other treatments (p < 0.05). The irradiations with neutrons alone and neutrons + BOPP showed curves that did not differ significantly from, and showed less DNA damage than, irradiation with neutrons + BPA. A decrease in the surviving fraction measured by 3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolium bromide (MTT) assay as a function of the absorbed dose was observed for all the treatments. The RBE and CBE factors calculated from cytokinesis block micronucleus (CBMN) and MTT assays were, respectively, the following: beam RBE: 4.4 {+-} 1.1 and 2.4 {+-} 0.6; CBE for BOPP: 8.0 {+-} 2.2 and 2.0 {+-} 1; CBE for BPA: 19.6 {+-} 3.7 and 3.5 {+-} 1.3. Conclusions: BNCT and gamma irradiations showed different genotoxic patterns. To our knowledge, these values represent the first experimental ones obtained for the RA-3 in a biologic model and could be useful for future experimental studies for the application of BNCT to colon carcinoma.

  5. Decision Summaries | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Information Center Decision Summaries Decision Summaries June 19, 2015 Summary of Decisions - June 15, 2015 - June 19, 2015 Decisions were issued on: - Personnel Security (10...

  6. Feasibility of developing a portable driver performance data acquisition system for human factors research: Technical tasks. Volume 1

    SciTech Connect (OSTI)

    Carter, R.J.; Barickman, F.S.; Spelt, P.F.; Schmoyer, R.L.; Kirkpatrick, J.R.

    1998-01-01

    A two-phase, multi-year research program entitled ``development of a portable driver performance data acquisition system for human factors research`` was recently completed. The primary objective of the project was to develop a portable data acquisition system for crash avoidance research (DASCAR) that will allow drive performance data to be collected using a large variety of vehicle types and that would be capable of being installed on a given vehicle type within a relatively short-time frame. During phase 1 a feasibility study for designing and fabricating DASCAR was conducted. In phase 2 of the research DASCAR was actually developed and validated. This technical memorandum documents the results from the feasibility study. It is subdivided into three volumes. Volume one (this report) addresses the last five items in the phase 1 research and the first issue in the second phase of the project. Volumes two and three present the related appendices, and the design specifications developed for DASCAR respectively. The six tasks were oriented toward: identifying parameters and measures; identifying analysis tools and methods; identifying measurement techniques and state-of-the-art hardware and software; developing design requirements and specifications; determining the cost of one or more copies of the proposed data acquisition system; and designing a development plan and constructing DASCAR. This report also covers: the background to the program; the requirements for the project; micro camera testing; heat load calculations for the DASCAR instrumentation package in automobile trunks; phase 2 of the research; the DASCAR hardware and software delivered to the National Highway Traffic Safety Administration; and crash avoidance problems that can be addressed by DASCAR.

  7. Management decisions for cogeneration : executive summary

    E-Print Network [OSTI]

    Radcliffe, Robert R.

    1982-01-01

    This report summarizes two interdependent studies which explore the underlying factors in the decision by private, private non-profit, and public sector facility owners to invest in cogeneration technology. They employ ...

  8. Human Factors Guidance for Control Room and Digital Human-System Interface Design and Modification, Guidelines for Planning, Specification, Design, Licensing, Implementation, Training, Operation and Maintenance

    SciTech Connect (OSTI)

    R. Fink, D. Hill, J. O'Hara

    2004-11-30

    Nuclear plant operators face a significant challenge designing and modifying control rooms. This report provides guidance on planning, designing, implementing and operating modernized control rooms and digital human-system interfaces.

  9. 1Il!11: m:mm:lli11I,111 Illili:llili!!ill,1ll ill ill!!ii111,111,111 mm; 206 THE HUMAN FACTOR HAS KNOCKED THREE TIMES

    E-Print Network [OSTI]

    Meyer, Bertrand

    ................................................................................................................................ THE HUMAN FACTOR HAS KNOCKED THREE TIMES Three books on the ergonomics of computing systems B. Meyer vanous names to it: the ergonomics of computing systems, the study of human factors, software psy style, evaluation of software quality, data base management systems, use o.f natural language and design

  10. 8/27/2014 Human Factors and Ergonomics Society: WhyAren't Product Designers Considering ActivityTrackers for Older Adults? https://www.hfes.org//Web/DetailNews.aspx?ID=340 1/2

    E-Print Network [OSTI]

    8/27/2014 Human Factors and Ergonomics Society: WhyAren't Product Designers Considering Activity benefits, product designers rarely consider those over 65 to be a viable user group, and new human factors/ergonomics and Ergonomics in Health Care in April, authors Preusse, Tracy Mitzner, Cara Fausset, and Wendy Rogers designed

  11. Human Factors Process Failure Mode and Effects Analysis (HF PFMEA) Application in the Evaluation of Management Risks

    E-Print Network [OSTI]

    Soguilon, Nenita M.

    2009-12-18

    Human errors in engineering processes do not usually get analyzed and evaluated in terms of their risks, much less management errors. Not much effort is expended on management errors and risks analysis, probably because not many have come to realize...

  12. The Cat (Felis catus) as an Example of the Contribution that Comparative Psychology Has Made to Human Factors

    E-Print Network [OSTI]

    White, Duncan A

    1992-01-01

    development in kittens {Felis catus): A cross- ComparativeVol. No. THE CAT (Felis catus) AS AN EXAMPLE OF THEinto human behavior. The cat {Felis catus) is a particularly

  13. Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells

    SciTech Connect (OSTI)

    Matsuzaki, Shinichi; Ishizuka, Tamotsu; Yamada, Hidenori; Kamide, Yosuke; Hisada, Takeshi; Ichimonji, Isao; Aoki, Haruka; Yatomi, Masakiyo; Komachi, Mayumi; Tsurumaki, Hiroaki; Ono, Akihiro; Koga, Yasuhiko; Dobashi, Kunio; Mogi, Chihiro; Sato, Koichi; Tomura, Hideaki; Mori, Masatomo; Okajima, Fumikazu

    2011-10-07

    Highlights: {yields} The involvement of extracellular acidification in airway remodeling was investigated. {yields} Extracellular acidification alone induced CTGF production in human ASMCs. {yields} Extracellular acidification enhanced TGF-{beta}-induced CTGF production in human ASMCs. {yields} Proton-sensing receptor OGR1 was involved in acidic pH-stimulated CTGF production. {yields} OGR1 may play an important role in airway remodeling in asthma. -- Abstract: Asthma is characterized by airway inflammation, hyper-responsiveness and remodeling. Extracellular acidification is known to be associated with severe asthma; however, the role of extracellular acidification in airway remodeling remains elusive. In the present study, the effects of acidification on the expression of connective tissue growth factor (CTGF), a critical factor involved in the formation of extracellular matrix proteins and hence airway remodeling, were examined in human airway smooth muscle cells (ASMCs). Acidic pH alone induced a substantial production of CTGF, and enhanced transforming growth factor (TGF)-{beta}-induced CTGF mRNA and protein expression. The extracellular acidic pH-induced effects were inhibited by knockdown of a proton-sensing ovarian cancer G-protein-coupled receptor (OGR1) with its specific small interfering RNA and by addition of the G{sub q/11} protein-specific inhibitor, YM-254890, or the inositol-1,4,5-trisphosphate (IP{sub 3}) receptor antagonist, 2-APB. In conclusion, extracellular acidification induces CTGF production through the OGR1/G{sub q/11} protein and inositol-1,4,5-trisphosphate-induced Ca{sup 2+} mobilization in human ASMCs.

  14. Decision analysis for seismic retrofit of structures 

    E-Print Network [OSTI]

    Williams, Ryan J.

    2009-05-15

    as well as the seismic hazard at a specific building location is incorporated into the decision-making process. The prescribed methodology is used to study two identical reinforced concrete buildings, one located in Memphis, Tennessee and one in San... in the NMFZ compared to that in California as well as human bias in the decision-making process, a quantitative measure of the economic costs and benefits of seismic retrofitting that considers the probability of occurrence of seismic events is necessary...

  15. EVALUATING ENVIRONMENTAL DECISION SUPPORT TOOLS.

    SciTech Connect (OSTI)

    SULLIVAN, T.

    2004-10-01

    Effective contaminated land management requires a number of decisions addressing a suite of technical, economic, and social concerns. These concerns include human health risks, ecological risks, economic costs, technical feasibility of proposed remedial actions, and the value society places on clean-up and re-use of formerly contaminated lands. Decision making, in the face of uncertainty and multiple and often conflicting objectives, is a vital and challenging role in environmental management that affects a significant economic activity. Although each environmental remediation problem is unique and requires a site-specific analysis, many of the key decisions are similar in structure. This has led many to attempt to develop standard approaches. As part of the standardization process, attempts have been made to codify specialist expertise into decision support tools. This activity is intended to facilitate reproducible and transparent decision making. The process of codifying procedures has also been found to be a useful activity for establishing and rationalizing management processes. This study will have two primary objectives. The first is to develop taxonomy for Decision Support Tools (DST) to provide a framework for understanding the different tools and what they are designed to address in the context of environmental remediation problems. The taxonomy will have a series of subject areas for the DST. From these subjects, a few key areas will be selected for further study and software in these areas will be identified. The second objective, will be to review the existing DST in the selected areas and develop a screening matrix for each software product.

  16. Sequence-specific sup 1 H-NMR assignments and identification of two small antiparallel. beta. -sheets in the solution structure of recombinant human transforming growth factor. alpha

    SciTech Connect (OSTI)

    Montelione, G.T.; Wagner, G. (Univ. of Michigan, Ann Arbor (USA)); Winkler, M.E.; Burton, L.E.; Rinderknecht, E. (Genetech, Inc., San Francisco (CA)); Sporn, M.B. (National Institutes of Health, Bethesda, MD (USA))

    1989-03-01

    Transforming growth factor {alpha} (TGF{alpha}) is a small mitogenic protein with about 35% sequence identity with epidermal growth factor (EGF). TGF{alpha}-like proteins have been proposed to play a role in oncogenesis and wound healing. This report describes sequence-specific {sup 1}H-NMR resonance assignments for recombinant human TGF{alpha} (hTGF{alpha}). These assignments provide the basis for interpreting NMR data which demonstrate that the solution structure of hTGF{alpha} includes an antiparallel {beta}-sheet involving residues Gly-19 to Leu-24 and Lys-29 to Cys-34 and a second, smaller, antiparallel {beta}-sheet involving residues Tyr-38 and Val-39 and His-45 and Ala-46. These data, together with constraints imposed by the disulfide bonds, are combined to construct a molecular model of the polypeptide chain fold for residues Cys-8 to Ala-46. The resulting structure is similar to that of mouse and human EGF. Human TGF{alpha} and mouse EGF, however, differ with respect to their structural dynamics, since amide proton/deuteron exchange is much faster for hTGF{alpha} than for mouse EGF at pH 3.5.

  17. Aging and decision making 

    E-Print Network [OSTI]

    Miller, Sophie

    2010-06-30

    The study sought to clarify the effects of aging in regard to decision making abilities. Decision making is dependent upon the Frontal Cortex structures; the Orbitofrontal Cortex and the Dorsolateral Prefrontal Cortex. These structures are thought...

  18. Human-machine interactions

    DOE Patents [OSTI]

    Forsythe, J. Chris (Sandia Park, NM); Xavier, Patrick G. (Albuquerque, NM); Abbott, Robert G. (Albuquerque, NM); Brannon, Nathan G. (Albuquerque, NM); Bernard, Michael L. (Tijeras, NM); Speed, Ann E. (Albuquerque, NM)

    2009-04-28

    Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

  19. LCdr. Michael Shumberger, USN (ret), Dr. Andrew Duchowski, and Mr. Kevin Charlow Human Factors Engineering in Command, Control &

    E-Print Network [OSTI]

    Duchowski, Andrew T.

    , and security engineering functions in accordance with the Defense Acquisition System Directive, 5000.1 the processes and activities of international standard ISO/IEC 12207, Software Life-Cycle Processes Factors concepts, as they relate to software development are briefly reviewed with references to the ISO

  20. Omeprazole Stimulates the Induction of Human Insulin-Like Growth Factor Binding Protein-1 through Aryl Hydrocarbon

    E-Print Network [OSTI]

    Perdew, Gary

    gene reveals the presence of an aryl hydrocarbon binding/dioxin response element (DRE). Quan- titative factor capable of binding dioxin response elements (DRE) and initiating transcription of Ah,3,7,8-tetrachlorodibenzo-p- dioxin (TCDD) being the prototypical example; polycyclic aromatic hydrocarbons, e.g., benzo

  1. Estrogen induced concentration dependent differential gene expression in human breast cancer (MCF7) cells: Role of transcription factors

    SciTech Connect (OSTI)

    Chandrasekharan, Sabarinath; Kandasamy, Krishna Kumar; Dayalan, Pavithra; Ramamurthy, Viraragavan

    2013-08-02

    Highlights: •Estradiol (E2) at low dose induced cell proliferation in breast cancer cells. •E2 at high concentration induced cell stress in breast cancer cells. •Estrogen receptor physically interacts only with a few transcription factors. •Differential expression of genes with Oct-1 binding sites increased under stress. •Transcription factor binding sites showed distinct spatial distribution on genes. -- Abstract: Background: Breast cancer cells respond to estrogen in a concentration dependent fashion, resulting in proliferation or apoptosis. The mechanism of this concentration dependent differential outcome is not well understood yet. Methodology: Meta-analysis of the expression data of MCF7 cells treated with low (1 nM) or high (100 nM) dose of estradiol (E2) was performed. We identified genes differentially expressed at the low or the high dose, and examined the nature of regulatory elements in the vicinity of these genes. Specifically, we looked for the difference in the presence, abundance and spatial distribution of binding sites for estrogen receptor (ER) and selected transcription factors (TFs) in the genomic region up to 25 kb upstream and downstream from the transcription start site (TSS) of these genes. Results: It was observed that at high dose E2 induced the expression of stress responsive genes, while at low dose, genes involved in cell cycle were induced. We found that the occurrence of transcription factor binding regions (TFBRs) for certain factors such as Sp1 and SREBP1 were higher on regulatory regions of genes expressed at low dose. At high concentration of E2, genes with a higher frequency of Oct-1 binding regions were predominantly involved. In addition, there were differences in the spatial distribution pattern of the TFBRs in the genomic regions among the two sets of genes. Discussion: E2 induced predominantly proliferative/metabolic response at low concentrations; but at high concentration, stress–rescue responses were induced. At high E2 concentration, classical genomic pathway involving ER binding to the regulatory regions was reduced, and alternate or indirect activation of genes through Oct-1 became more prominent.

  2. The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: Down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin

    SciTech Connect (OSTI)

    Song Jin; Jie Chunfa; Polk, Paula; Shridhar, Ravi; Clair, Timothy; Zhang, Jun; Yin, Lijia; Keppler, Daniel . E-mail: dkeppl@lsuhsc.edu

    2006-02-03

    We recently coined CST6 as a novel candidate tumor suppressor gene for breast cancer. CST6 indeed is expressed in the normal human breast epithelium, but little or not at all in breast carcinomas and breast cancer cell lines. Moreover, ectopic expression of CST6 in human breast cancer cells suppressed cell proliferation, migration, invasion, and orthotopic tumor growth. To obtain insights into the molecular mechanism by which CST6 exhibits its pleiotropic effects on tumor cells, we compared global gene expression profiles in mock- and CST6-transfected human MDA-MB-435S cells. Out of 12,625 transcript species, 61 showed altered expression. These included genes for extracellular matrix components, cytokines, kinases, and phosphatases, as well as several key transcription factors. TaqMan PCR assays were used to confirm the microarray data for 7 out of 11 genes. One down-regulated gene product, secreted autotaxin/lyso-phospholipase D, was of particular interest because its down-regulation by CST6 could explain most of CST6's effect on the breast cancer cells. This study thus provides First evidence that CST6 plays a role in the modulation of genes, particularly, genes that are highly relevant to breast cancer progression.

  3. Record of Decision Available

    Broader source: Energy.gov [DOE]

    DOE has recently published its Record of Decision announcing and explaining DOE’s chosen project alternative and describing any commitments for mitigating potential environmental impacts. The NEPA...

  4. Automation and Accountability in Decision Support System Interface Design

    E-Print Network [OSTI]

    Cummings, M. L.

    2006-01-01

    When the human element is introduced into decision support system design, entirely new layers of social and ethical issues emerge but are not always recognized as such. This paper discusses those ethical and social impact ...

  5. Implementing Motor Decision Plans 

    E-Print Network [OSTI]

    Elliott, R. N.

    2001-01-01

    The first step to reducing energy costs and increasing reliability in motors is to establish a motor plan. A motor plan allows decisions to be made in advance of motor failure, and increases the options available. By contrast, most motor decisions...

  6. A human factors approach towards the design of a new glovebox glove for Los Alamos National Laboratory

    SciTech Connect (OSTI)

    Oka, Jude M.

    2012-08-06

    Present day glovebox gloves at Los Alamos National Laboratory (LANL) are underdeveloped and ergonomically inaccurate. This problem results in numerous sprain and strain injuries every year for employees who perform glovebox work. In addition to injuries, using the current glovebox glove design also contributes to breaches and contamination. The current glove used today at LANL has several problems: (1) The length of the fingers is incorrect, (2) the web spacing between the fingers is nonexistent, (3) the angles between each digit on the finger are incorrect, (4) the thumb is placed inaccurately, and (5) the length of the hand is incorrect. These problems present a need to correct the current glove design to decrease the risk of injuries, breaches, and contamination. Anthropometrics were researched to help find the best range of hand measurements to fix the current glove design. Anthropometrics is the measure of the human physical variation. Anthropometrics for this study were gathered from the American National Survey (ANSUR) data that was conducted by the U.S Army in 1988. The current glovebox glove uses anthropometrics from the 95th to 105th percentile range which is too large so the new gloves are going to implement data from a smaller range of percentile groups. The 105th percentile range represents measurements that exceed the human population but are needed to fit certain circumstance such as wearing several under gloves within the glovebox gloves. Anthropometrics used in this study include: 105th percentile measurements for joint circumference which was unchanged because the room for under gloves plus ease of hand insertion and extraction is needed, 80th percentile measurements for crotch length to allow workers to reach the web spacing in the glove, 20th percentile measurements for finger length to allow workers to reach the end of the glove, standard 10.5cm hand breadth to allow more room to accommodate under gloves, 45 degrees abduction angle for the thumb for better positioning, 45 degrees extension angle for the thumb for better positioning, and various angles for the other fingers to allow a more relaxed and natural fit. 3D modeling was used to implement the anthropometric data listed above onto an existing scanned solid model of a human hand. SolidWorks 2010 3-D modeling package was utilized to manipulate the hand model to represent the anthropometric data researched. The anthropometrics and modifications were reviewed by the University of New Mexico Department of Orthopedics hand surgeons. After all modifications and reviews were completed the model was printed out using stereolithography. The printed out model of the hand was used as a mold to create a prototype glovebox glove. The new mold was taken to Piercan USA to produce a 20mil Polyurethane/Hypalon glovebox glove. The Minnesota Dexterity test and Purdue Pegboard test were used to measure the dexterity of the prototype glovebox glove against a current 15 mil Hypalon LANL glovebox glove. Using the data from the tests a student t test was used to determine if there was a significant difference between the current hypalon glove results and the new prototype glove results. With a 95% confidence level the prototype showed to have a significantly lower mean difference from the current hypalon glovebox glove with the Minnesota Dexterity test. With a 95% confidence level the prototype showed to have a significantly higher mean difference from the current hypalon glovebox glove with the Purdue Pegboard test. A p value method was also performed to confirm the results of the student t test. A survey was also given to glovebox workers to determine if they preferred the new design. The best reaction from glovebox workers was the new thumb position, 73.2% of the sample population agreed with the new thumb position. Developing a new glovebox glove will improve the ergonomics of the hand for work performed, decrease exposure time, decreasing risk of breaching, increasing productivity, reducing injuries, and improving work performance. In the future the new glovebox

  7. Human Health Risk & Environmental Analysis | Clean Energy | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Health Risk and Environmental Analysis SHARE Human Health Risk and Environmental Analysis Help decision makers assess emerging technologies and methods for identifying and...

  8. Representing Uncertainty in Decision Support Harvey J. Greenberg

    E-Print Network [OSTI]

    Greenberg, Harvey J.

    overlapping factors. · Source of uncertainty. Is it a future event, such as product demand? Is it ignorance defines a proven reserve? · Time scale. Is the decision a strategic one, to cover a planning horizon? Is it a major setback, such as the loss of a company? Is it catastrophic, such as the loss of a city? · Decision

  9. Case Study 2: Housing Decisions: Renting Versus Owning

    E-Print Network [OSTI]

    Colton, Jonathan S.

    Case Study 2: Housing Decisions: Renting Versus Owning Concepts illustrated: Federal taxation or noneconomic. Minimization of unit housing costs obviously is an economic decision. Certain individuals may wish to allocate a speci c portion of their income to housing. Mobility, an important factor to some

  10. Fibroblast growth factor 2 inhibits up-regulation of bone morphogenic proteins and their receptors during osteoblastic differentiation of human mesenchymal stem cells

    SciTech Connect (OSTI)

    Biver, Emmanuel, E-mail: ebiver@yahoo.fr [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France) [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France); Department of Rheumatology, Lille University Hospital, Roger Salengro Hospital, 59037 Lille cedex (France); Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, CH-1211 Geneva 14 (Switzerland); Soubrier, Anne-Sophie [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France) [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France); Department of Rheumatology, Lille University Hospital, Roger Salengro Hospital, 59037 Lille cedex (France); Thouverey, Cyril [Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, CH-1211 Geneva 14 (Switzerland)] [Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, CH-1211 Geneva 14 (Switzerland); Cortet, Bernard [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France) [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France); Department of Rheumatology, Lille University Hospital, Roger Salengro Hospital, 59037 Lille cedex (France); Broux, Odile [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France)] [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France); Caverzasio, Joseph [Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, CH-1211 Geneva 14 (Switzerland)] [Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, CH-1211 Geneva 14 (Switzerland); Hardouin, Pierre [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France)] [Physiopathology of Inflammatory Bone Diseases, EA 4490, University Lille North of France, Quai Masset, Bassin Napoleon, BP120, 62327 Boulogne sur Mer (France)

    2012-11-02

    Highlights: Black-Right-Pointing-Pointer FGF modulates BMPs pathway in HMSCs by down-regulating BMP/BMPR expression. Black-Right-Pointing-Pointer This effect is mediated by ERK and JNK MAPKs pathways. Black-Right-Pointing-Pointer Crosstalk between FGF and BMPs must be taken into account in skeletal bioengineering. Black-Right-Pointing-Pointer It must also be considered in the use of recombinant BMPs in orthopedic and spine surgeries. -- Abstract: Understanding the interactions between growth factors and bone morphogenic proteins (BMPs) signaling remains a crucial issue to optimize the use of human mesenchymal stem cells (HMSCs) and BMPs in therapeutic perspectives and bone tissue engineering. BMPs are potent inducers of osteoblastic differentiation. They exert their actions via BMP receptors (BMPR), including BMPR1A, BMPR1B and BMPR2. Fibroblast growth factor 2 (FGF2) is expressed by cells of the osteoblastic lineage, increases their proliferation and is secreted during the healing process of fractures or in surgery bone sites. We hypothesized that FGF2 might influence HMSC osteoblastic differentiation by modulating expressions of BMPs and their receptors. BMP2, BMP4, BMPR1A and mainly BMPR1B expressions were up-regulated during this differentiation. FGF2 inhibited HMSCs osteoblastic differentiation and the up-regulation of BMPs and BMPR. This effect was prevented by inhibiting the ERK or JNK mitogen-activated protein kinases which are known to be activated by FGF2. These data provide a mechanism explaining the inhibitory effect of FGF2 on osteoblastic differentiation of HMSCs. These crosstalks between growth and osteogenic factors should be considered in the use of recombinant BMPs in therapeutic purpose of fracture repair or skeletal bioengineering.

  11. Hypoxia-inducible factor-1? (HIF-1?) is upregulated in a HIF-1?-dependent manner in 518A2 human melanoma cells under hypoxic conditions

    SciTech Connect (OSTI)

    Mandl, Markus, E-mail: mmandl@mail.austria.com; Kapeller, Barbara; Lieber, Roman; Macfelda, Karin

    2013-04-26

    Highlights: •HIF-1? is a hypoxia-responsive protein in 518A2 human melanoma cells. •HIF-1? is upregulated in a HIF-1?-dependent manner under hypoxic conditions. •HIF-1? is not elevated due to heterodimerization with HIF-1? per se. •HIF-1? inducibility has a biological relevance as judged in Het-CAM model. -- Abstract: Solid tumors include hypoxic areas due to excessive cell proliferation. Adaptation to low oxygen levels is mediated by the hypoxia-inducible factor (HIF) pathway promoting invasion, metastasis, metabolic alterations, chemo-resistance and angiogenesis. The transcription factor HIF-1, the major player within this pathway consists of HIF-1? and HIF-1?. The alpha subunit is continuously degraded under normoxia and becomes stabilized under reduced oxygen supply. In contrast, HIF-1? is generally regarded as constitutively expressed and being present in excess within the cell. However, there is evidence that the expression of this subunit is more complex. The aim of this study was to investigate the role of HIF-1? in human melanoma cells. Among a panel of five different cell lines, in 518A2 cells exposed to the hypoxia-mimetic cobalt chloride HIF-1? was rapidly elevated on protein level. Knockdown experiments performed under cobalt chloride-exposure and hypoxia revealed that this effect was mediated by HIF-1?. The non-canonical relationship between these subunits was further confirmed by pharmacologic inhibition of HIF-1? and by expression of a dominant-negative HIF mutant. Overexpression of HIF-1? showed a time delay in HIF-1? induction, thus arguing for HIF-1? de novo synthesis rather than protein stabilization by heterodimerization. A Hen’s egg test-chorioallantoic membrane model of angiogenesis and invasion indicated a local expression of HIF-1? and implies a biological relevance of these findings. In summary, this study demonstrates the HIF-1?-dependent regulation of HIF-1? under hypoxic conditions for the first time. The results indicate a novel cell specific mechanism which might prevent HIF-1? to become a limiting factor.

  12. Essays in decision making

    E-Print Network [OSTI]

    Chang, Tom Y., 1976-

    2009-01-01

    This thesis explores the impact of individual decision making on the functioning of firms and markets. The first chapter examines how deviations from strict rationality by individuals impact the market for consumer goods. ...

  13. UNDERSTANDING HOME RENOVATION DECISIONS

    E-Print Network [OSTI]

    Watson, Andrew

    UNDERSTANDING HOME RENOVATION DECISIONS - A Research Project - Background to Our Research Energy to renovate their homes. We're interested in energy efficiency, but in all other efficient renova/ons can lower energy bills, improve comfort by reducing dra

  14. SupernetworksSupernetworks Decision-Making in the 21Decision-Making in the 21stst

    E-Print Network [OSTI]

    Nagurney, Anna

    events; · complex interactions among decision- makers in organizations; · alternative and at times and energy networks. No longer are networks independent of one another but critically linked with major were laid, bridges built, and waterways crossed so that humans, be they on foot, on animal, or vehicle

  15. Artificial Intelligence Decision and Information

    E-Print Network [OSTI]

    Polani, Daniel

    Artificial Intelligence Decision and Information Daniel Polani Artificial Intelligence ­ p.1/26 Decisions: The Fundamental Task Motivation: everything in Artificial Intelligence is basical about taking Intellige Decision: What Door to Open? Artificial Intelligence ­ p.3/26 Bottom Line Clear: decision about

  16. USEtox - The UNEP-SETAC toxicity model: recommended characterisation factors for human toxicity and freshwater ecotoxicity in Life Cycle Impact Assessment

    E-Print Network [OSTI]

    Rosenbaum, Ralph K.

    2010-01-01

    characterisation factors (CFs) is within a factor of 100-variation between the CFs of each model respectively. Thebeen used to calculate CFs for several thousand substances

  17. Regulation of insulin-like growth factor binding protein-4 in Ah responsive and Ah nonresponsive human breast cancer cells by 17 B-estradiol and 2,3,7,8 tetrachlorodibenzo-p-dioxin 

    E-Print Network [OSTI]

    Schrope, Katherine Eillene

    1997-01-01

    This study focused on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on insulin-like growth factor binding protein-4 (IGFBP-4) protein secretion and MRNA expression. In human breast cancer cells, 17 O-estradiol (E2) induced IGFBP-4...

  18. Evidence-based Decision Making: Influences on Central-Office Administrators' Decision-Making Practices 

    E-Print Network [OSTI]

    Haecker, Bonnie Minnia

    2013-12-05

    of this quantitative non-experimental study was to identify the evidence-based decision-making practices of central office administrators (n = 268) and the factors that influence them. Based on the findings in the literature, a survey was developed to collect data...

  19. http://erg.sagepub.com/ Factors Applications

    E-Print Network [OSTI]

    Kaber, David B.

    http://erg.sagepub.com/ Factors Applications Ergonomics in Design: The Quarterly of Human httpErgonomics in Design: The Quarterly of Human Factors Applications Peter A. Hancock, Richard J. Jagacinski: Human Factors and Ergonomics Society can be found at:Ergonomics in Design: The Quarterly of Human

  20. The anti-tumor effect of cross-reacting material 197, an inhibitor of heparin-binding EGF-like growth factor, in human resistant ovarian cancer

    SciTech Connect (OSTI)

    Tang, Xiao-han; Deng, Suo; Li, Meng; Lu, Mei-song

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer HB-EGF over-expression in A2780/Taxol, A2780/CDDP cells and the matched xenografts. Black-Right-Pointing-Pointer CRM197 induces enhanced apoptosis in A2780/Taxol and A2780/CDDP cells. Black-Right-Pointing-Pointer CRM197 arrests A2780/Taxol and A2780/CDDP cells at G0/G1 phase. Black-Right-Pointing-Pointer CRM197 suppressed the A2780/Taxol and A2780/CDDP growth of xenografts. -- Abstract: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for ovarian cancer therapy. Cross-reacting material 197 (CRM197), a specific HB-EGF inhibitor, has been proven to represent possible chemotherapeutic agent for ovarian cancer. However, the effect of CRM197 on the resistant ovarian carcinoma cells has not been sufficiently elucidated. Here, we found that HB-EGF was over-expressed in a paclitaxel-resistant human ovarian carcinoma cell line (A2780/Taxol) and a cisplatin-resistant cell line (A2780/CDDP), as well as the xenograft mouse tissue samples with these cells. To investigate the possible significance of the HB-EGF over-expression in A2780/Taxol and A2780/CDDP cells, we inhibited HB-EGF expression by CRM197 to investigate the effect of CRM197 treatment on these cells. We observed that CRM197 significantly induced anti-proliferative activity in a dose-dependent manner with the cell-cycle arrest at the G0/G1 phase and enhanced apoptosis in A2780/Taxol and A2780/CDDP cells. The sensitive ovarian carcinoma parental cell line (A2780), A2780/Taxol and A2780/CDDP cells formed tumors in nude mice, and enhanced tumorigenicity was observed in drug-resistant tumors. Furthermore, we observed that CRM197 significantly suppressed the growth of drug-resistant ovarian cancer xenografts in vivo (p < 0.001). These results suggest that CRM197 as an HB-EGF-targeted agent has potent anti-tumor activity in paclitaxel- and cisplatin-resistant ovarian cancer which over-express HB-EGF.

  1. Author's personal copy Application of rough set and decision tree for characterization

    E-Print Network [OSTI]

    Munakata, Toshinori

    theory; Decision tree; Earthquake prediction; Machine learning 1. Introduction Identifying to be used in predicting premonitory factors for earthquake. In recent years, researchers have identified a machine learning approach to characterizing premonitory factors of earthquake. The characteristic

  2. Record of Decision for Amchitka Surface Closure, Alaska

    SciTech Connect (OSTI)

    2008-08-01

    This Record of Decision has been prepared to document the remedial actions taken on Amchitka Island to stabilize contaminants associated with drilling mud pits generated as a result of nuclear testing operations conducted on the island. This document has been prepared in accordance with the recommended outline in the Alaska Department of Environmental Conservation guidance on decision documentation under the Site Cleanup Rules (18 AAC 75.325-18 AAC 75.390) (ADEC 1999). It also describes the decision-making process used to establish the remedial action plans and defines the associated human health and ecological risks for the remediation.

  3. Enabling effective product launch decisions

    E-Print Network [OSTI]

    Akamphon, Sappinandana

    2008-01-01

    The present work looks into the question of optimizing the performance of product launch decisions-in particular, the decisions of product development duration and manufacturing ramp-up. It presents an innovative model for ...

  4. Co-localization and regulation of basic fibroblast growth factor and arginine vasopressin in neuroendocrine cells of the rat and human brain

    E-Print Network [OSTI]

    2010-01-01

    EGS: Designed human hypothalamus/ neurohypophysis studies,1b receptor mRNA in the hypothalamus and choroid plexus.ribonucleic acid in rat hypothalamus. Horm Metab Res 1995,

  5. Co-localization and regulation of basic fibroblast growth factor and arginine vasopressin in neuroendocrine cells of the rat and human brain

    E-Print Network [OSTI]

    2010-01-01

    from NIH NS/AG-91-03 (E.G.S. ), NINDS NS 27601 and NIA AGand manuscript drafting. EGS: Designed human hypothalamus/

  6. Decision support for disaster management

    E-Print Network [OSTI]

    Rolland, Erik; Patterson, Raymond A.; Ward, Keith; Dodin, Bajis

    2010-01-01

    of the disaster management organizations. Therefore, thishybrid meta-heuristics. Keywords Disaster management . Meta-heuristics . Project management . Scheduling . Decision

  7. Arsenic in Bangladesh Decision analysis

    E-Print Network [OSTI]

    Gelman, Andrew

    Arsenic in Bangladesh Decision analysis Regression models Take-home points Arsenic and old models 2007 Andrew Gelman Arsenic and old models #12;Arsenic in Bangladesh Decision analysis Regression models Take-home points Contents Aresenic in Bangladesh Decision analysis Regression models Andrew Gelman

  8. Training Adaptive Decision-Making.

    SciTech Connect (OSTI)

    Abbott, Robert G.; Forsythe, James C.

    2014-10-01

    Adaptive Thinking has been defined here as the capacity to recognize when a course of action that may have previously been effective is no longer effective and there is need to adjust strategy. Research was undertaken with human test subjects to identify the factors that contribute to adaptive thinking. It was discovered that those most effective in settings that call for adaptive thinking tend to possess a superior capacity to quickly and effectively generate possible courses of action, as measured using the Category Generation test. Software developed for this research has been applied to develop capabilities enabling analysts to identify crucial factors that are predictive of outcomes in fore-on-force simulation exercises.

  9. Preference reversal in quantum decision theory

    E-Print Network [OSTI]

    V. I. Yukalov; D. Sornette

    2015-10-08

    We consider the psychological effect of preference reversal and show that it finds a natural explanation in the frame of quantum decision theory. When people choose between lotteries with non-negative payoffs, they prefer a more certain lottery because of uncertainty aversion. But when people evaluate lottery prices, e.g. for selling to others the right to play them, they do this more rationally, being less subject to behavioral biases. This difference can be explained by the presence of the attraction factors entering the expression of quantum probabilities. Only the existence of attraction factors can explain why, considering two lotteries with close utility factors, a decision maker prefers one of them when choosing, but evaluates higher the other one when pricing. We derive a general quantitative criterion for the preference reversal to occur that relates the utilities of the two lotteries to the attraction factors under choosing versus pricing and test successfully its application on experiments by Tversky et al. We also show that the planning paradox can be treated as a kind of preference reversal.

  10. Human CD34+ CD133+ Hematopoietic Stem Cells Cultured with Growth Factors Including Angptl5 Efficiently Engraft Adult NOD-SCID Il2r??/? (NSG) Mice

    E-Print Network [OSTI]

    Drake, Adam

    Increasing demand for human hematopoietic stem cells (HSCs) in clinical and research applications necessitates expansion of HSCs in vitro. Before these cells can be used they must be carefully evaluated to assess their ...

  11. An Ex-Vivo Model using Human Osteoarthritic Cartilage Demonstrates the Release of Bioactive Insulin-like growth factor- 1 from a Collagen-Glycosaminoglycan Scaffold.

    E-Print Network [OSTI]

    Wardale, J.; Mullen, L.; Howard, D.; Ghose, S.; Rushton, N.

    2015-01-01

    /types of cell, growth factors or therapeutic drugs before progressing to costly pre-clinical trials. Significance Pre clinical trials of biomaterials for cartilage repair are very costly and all too often studies progress directly from in vitro studies...

  12. IDHEAS – A NEW APPROACH FOR HUMAN RELIABILITY ANALYSIS

    SciTech Connect (OSTI)

    G. W. Parry; J.A Forester; V.N. Dang; S. M. L. Hendrickson; M. Presley; E. Lois; J. Xing

    2013-09-01

    This paper describes a method, IDHEAS (Integrated Decision-Tree Human Event Analysis System) that has been developed jointly by the US NRC and EPRI as an improved approach to Human Reliability Analysis (HRA) that is based on an understanding of the cognitive mechanisms and performance influencing factors (PIFs) that affect operator responses. The paper describes the various elements of the method, namely the performance of a detailed cognitive task analysis that is documented in a crew response tree (CRT), and the development of the associated time-line to identify the critical tasks, i.e. those whose failure results in a human failure event (HFE), and an approach to quantification that is based on explanations of why the HFE might occur.

  13. Impact of the spatial context on human communication activity

    E-Print Network [OSTI]

    Dashdorj, Zolzaya

    2015-01-01

    Technology development produces terabytes of data generated by hu- man activity in space and time. This enormous amount of data often called big data becomes crucial for delivering new insights to decision makers. It contains behavioral information on different types of human activity influenced by many external factors such as geographic infor- mation and weather forecast. Early recognition and prediction of those human behaviors are of great importance in many societal applications like health-care, risk management and urban planning, etc. In this pa- per, we investigate relevant geographical areas based on their categories of human activities (i.e., working and shopping) which identified from ge- ographic information (i.e., Openstreetmap). We use spectral clustering followed by k-means clustering algorithm based on TF/IDF cosine simi- larity metric. We evaluate the quality of those observed clusters with the use of silhouette coefficients which are estimated based on the similari- ties of the mobile commun...

  14. Physics 105 Physics for Decision Makers: The Global Energy Crisis

    E-Print Network [OSTI]

    Lathrop, Daniel P.

    Physics 105 Fall 2012 Physics for Decision Makers: The Global Energy Crisis Professor Steve Rolston of energy and energy usage in the world, and the human impact on the global climate. · To learn, through the important societal questions of energy usage and environmental impact. This is a Marquee Science

  15. iRESM INITIATIVE UNDERSTANDING DECISION SUPPORT NEEDS FOR CLIMATE CHANGE MITIGATION AND ADAPTATION --US Midwest Region—

    SciTech Connect (OSTI)

    Rice, Jennie S.; Runci, Paul J.; Moss, Richard H.; Anderson, Kate L.

    2010-10-01

    The impacts of climate change are already affecting human and environmental systems worldwide, yet many uncertainties persist in the prediction of future climate changes and impacts due to limitations in scientific understanding of relevant causal factors. In particular, there is mounting urgency to efforts to improve models of human and environmental systems at the regional scale, and to integrate climate, ecosystem and energy-economic models to support policy, investment, and risk management decisions related to climate change mitigation (i.e., reducing greenhouse gas emissions) and adaptation (i.e., responding to climate change impacts). The Pacific Northwest National Laboratory (PNNL) is developing a modeling framework, the integrated Regional Earth System Model (iRESM), to address regional human-environmental system interactions in response to climate change and the uncertainties therein. The framework will consist of a suite of integrated models representing regional climate change, regional climate policy, and the regional economy, with a focus on simulating the mitigation and adaptation decisions made over time in the energy, transportation, agriculture, and natural resource management sectors.

  16. Latent effects decision analysis

    DOE Patents [OSTI]

    Cooper, J. Arlin (Albuquerque, NM); Werner, Paul W. (Albuquerque, NM)

    2004-08-24

    Latent effects on a system are broken down into components ranging from those far removed in time from the system under study (latent) to those which closely effect changes in the system. Each component is provided with weighted inputs either by a user or from outputs of other components. A non-linear mathematical process known as `soft aggregation` is performed on the inputs to each component to provide information relating to the component. This information is combined in decreasing order of latency to the system to provide a quantifiable measure of an attribute of a system (e.g., safety) or to test hypotheses (e.g., for forensic deduction or decisions about various system design options).

  17. FEATURE ARTICLES Group Decision Making

    E-Print Network [OSTI]

    FEATURE ARTICLES Group Decision Making in Honey Bee Swarms When 10,000 bees go house hunting, how a neighboring colony. A striking example of decision mak- ing by an animal group is the choice of a nesting site paper on house hunting by honey bees. Lindauer was then a postdtx:toral stu- dent at the University

  18. Proceedings of the Second Conference on the Human Dimensions of Wildland Fire GTR-NRS-P-84 14 CHANGE AS A FACTOR IN ADVANCING FIRE-MANAGEMENT

    E-Print Network [OSTI]

    CHANGE AS A FACTOR IN ADVANCING FIRE-MANAGEMENT DECISIONMAKING AND PROGRAM EFFECTIVENESS Thomas Zimmerman change. To become better able to meet changing conditions and complexity, fire management must be agile to change. In fact, fire management has involved such continual change that it has been described

  19. An object-oriented approach to site characterization decision support

    SciTech Connect (OSTI)

    Johnson, R.

    1995-06-01

    Effective decision support for site characterization is key to determining the nature and extent of contamination and the associated human and environmental risks. Site characterization data, however, present particular problems to technical analysts and decision-makers. Such data are four dimensional, incorporating temporal and spatial components. Their sheer volume can be daunting -- sites with hundreds of monitoring wells and thousands of samples sent for laboratory analyses are not uncommon. Data are derived from a variety of sources including laboratory analyses, non-intrusive geophysical surveys, historical information, bore logs, in-field estimates of key physical parameters such as aquifer transmissivity, soil moisture content, depth-to-water table, etc. Ultimately, decisions have to be made based on data that are always incomplete, often confusing, inaccurate, or inappropriate, and occasionally wrong. In response to this challenge, two approaches to environmental decision support have arisen, Data Quality Objectives (DQOS) and the Observational Approach (OA). DQOs establish criteria for data collection by clearly defining the decisions that need to be made, the uncertainty that can be tolerated, and the type and amount of data that needs to be collected to satisfy the uncertainty requirements. In practice, DQOs are typically based on statistical measures. The OA accepts the fact that the process of characterizing and remediating contaminated sites is always uncertain. Decision-making with the OA is based on what is known about a site, with contingencies developed for potential future deviations from the original assumptions about contamination nature, extent, and risks posed.

  20. Factored MDPs for Optimal Prosumer Decision-Making Angelos Angelidakis

    E-Print Network [OSTI]

    Chalkiadakis, Georgios

    .ifaamas.org). All rights reserved. producing electricity from (mainly) renewable energy resources, and which has. Paradigms of such community-oriented and renewable energy-relying microgrids are expected to be commonplace a consumer) when selling and buying energy in the emerging smart electricity grid, is of utmost importance

  1. Decision Motivations: Factors Guiding the Choices of Agriculturalists in California 

    E-Print Network [OSTI]

    Robel, Pamela

    2014-10-16

    series of qualitative interviews. The data from the qualitative interviews with California-based agriculturalists were analyzed to guide the creation of a survey instrument. The subsequent survey instrument was distributed to other California...

  2. Students' Perceptions of Food and Factors That Influence Purchasing Decisions 

    E-Print Network [OSTI]

    Smith, Lindsay Marie

    2013-06-06

    When it comes to food, college students need help selecting healthy food choices. Students are presented with many options to purchase food at grocery stores and restaurants and many of these options include organic food. ...

  3. MIDAS : minor incident decision analysis software

    E-Print Network [OSTI]

    Horng, Tze-Chieh, 1964-

    2004-01-01

    MIDAS is the minor incident decision analysis software that acts as an advisory tool for plant decision makers and operators to analyze the available decision alternatives for resolving minor incidents. The minor incidents ...

  4. Interactions between learning and decision making

    E-Print Network [OSTI]

    Tulabandhula, Theja

    2014-01-01

    We quantify the effects of learning and decision making on each other in three parts. In the first part, we look at how knowledge about decision making can influence learning. Let the decision cost be the amount spent by ...

  5. Contributions to risk-informed decision making

    E-Print Network [OSTI]

    Elliott, Michael A. (Michael Alfred)

    2010-01-01

    Risk-informed decision-making (RIDM) is a formal process that assists stakeholders make decisions in the face of uncertainty. At MIT, a tool known as the Analytic Deliberative Decision Making Process (ADP) has been under ...

  6. Trust-based design of human-guided algorithms

    E-Print Network [OSTI]

    Thomer, Joseph L. (Joseph Louis)

    2007-01-01

    By combining the strengths of human and computers, Human Machine Collaborative Decision Making has been shown to generate higher quality solutions in less time than conventional computerized methods. In many cases, it is ...

  7. Single-photon decision maker

    E-Print Network [OSTI]

    Naruse, Makoto; Drezet, Aurelien; Huant, Serge; Aono, Masashi; Hori, Hirokazu; Kim, Song-Ju

    2015-01-01

    Decision making is critical in our daily lives and for society in general and is finding evermore practical applications in information and communication technologies. Herein, we demonstrate experimentally that single photons can be used to make decisions in uncertain, dynamically changing environments. Using a nitrogen-vacancy in a nanodiamond as a single-photon source, we demonstrate the decision-making capability by solving the multi-armed bandit problem. This capability is directly and immediately associated with single-photon detection in the proposed architecture, leading to adequate and adaptive autonomous decision making. This study makes it possible to create systems that benefit from the quantum nature of light to perform practical and vital intelligent functions.

  8. Incorporating uncertainty into electric utility projections and decisions

    SciTech Connect (OSTI)

    Hanson, D.A.

    1992-01-01

    This paper focuses on how electric utility companies can respond in their decision making to uncertain variables. Here we take a mean- variance type of approach. The mean'' value is an expected cost, on a discounted value basis. We assume that management has risk preferences incorporating a tradeoff between the mean and variance in the utility's net income. Decisions that utilities are faced with can be classified into two types: ex ante and ex post. The ex ante decisions need to be made prior to the uncertainty being revealed and the ex post decision can be postponed until after the uncertainty is revealed. Intuitively, we can say that the ex ante decisions provide a hedge against the uncertainties and the ex post decisions allow the negative outcomes of uncertain variables to be partially mitigated, dampening the losses. An example of an ex post decision is how the system is operated i.e., unit dispatch, and in some cases switching among types of fuels, say with different sulfur contents. For example, if gas prices go up, natural gas combined cycle units are likely to be dispatched at lower capacity factors. If SO{sub 2} emission allowance prices go up, a utility may seek to switch into a lower sulfur coal. Here we assume that regulated electric utilities do have some incentive to lower revenue requirements and hence an incentive to lower the electric rates needed for the utility to break even, thereby earning a fair return on invested capital. This paper presents the general approach first, including applications to capacity expansion and system dispatch. Then a case study is presented focusing on the 1990 Clean Air Act Amendments including SO{sub 2} emissions abatement and banking of allowances under uncertainty. It is concluded that the emission banking decisions should not be made in isolation but rather all the uncertainties in demand, fuel prices, technology performance etc., should be included in the uncertainty analysis affecting emission banking.

  9. The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas

    SciTech Connect (OSTI)

    Sun, Yu; Wong, Nicholas; Guan, Yinghui; Salamanca, Clara M.; Cheng, Jung Chien; Lee, Jonathan M.; Gray, Joe W.; Auersperg, Nelly

    2008-04-25

    Ovarian epithelial carcinomas (OEC) frequently exhibit amplifications at the 20q13 locus which is the site of several oncogenes, including the eukaryotic elongation factor EEF1A2 and the transcription factor ZNF217. We reported previously that overexpressed ZNF217 induces neoplastic characteristics in precursor cells of OEC. Unexpectedly, ZNF217, which is a transcriptional repressor, enhanced expression of eEF1A2. In this study, array comparative genomic hybridization, single nucleotide polymorphism and Affymetrix analysis of ZNF217-overexpressing cell lines confirmed consistently increased expression of eEF1A2 but not of other oncogenes, and revealed early changes in EEF1A2 gene copy numbers and increased expression at crisis during immortalization. We defined the influence of eEF1A2 overexpression on immortalized ovarian surface epithelial cells, and investigated interrelationships between effects of ZNF217 and eEF1A2 on cellular phenotypes. Lentivirally induced eEF1A2 overexpression caused delayed crisis, apoptosis resistance and increases in serum-independence, saturation densities, and anchorage independence. siRNA to eEF1A2 reversed apoptosis resistance and reduced anchorage independence in eEF1A2-overexpressing lines. Remarkably, siRNA to eEF1A2 was equally efficient in inhibiting both anchorage independence and resistance to apoptosis conferred by ZNF217 overexpression. Our data define neoplastic properties that are caused by eEF1A2 in nontumorigenic ovarian cancer precursor cells, and suggest that eEF1A2 plays a role in mediating ZNF217-induced neoplastic progression.

  10. Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NF{kappa}B and AhR and EGFR-ERK pathway

    SciTech Connect (OSTI)

    Potapovich, Alla I. [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Biology Department, Belarus State University, Skorina Prosp. 10, Minsk 220050 (Belarus); Lulli, Daniela; Fidanza, Paolo [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Kostyuk, Vladimir A. [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Biology Department, Belarus State University, Skorina Prosp. 10, Minsk 220050 (Belarus); De Luca, Chiara; Pastore, Saveria [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy); Korkina, Liudmila G., E-mail: l.korkina@idi.it [Tissue Engineering and Skin Pathophysiology Laboratory, Dermatology Research Institute (IDI IRCCS), Via Monti di Creta 104, Rome 00167 (Italy)

    2011-09-01

    Molecular mechanisms underlying modulation of inflammatory responses in primary human keratinocytes by plant polyphenols (PPs), namely the glycosylated phenylpropanoid verbascoside, the stilbenoid resveratrol and its glycoside polydatin, and the flavonoid quercetin and its glycoside rutin were evaluated. As non-lethal stimuli, the prototypic ligand for epidermal growth factor receptor (EGFR) transforming growth factor alpha (TGFalpha), the combination of tumor necrosis factor (TNFalpha) and interferon (IFNgamma) (T/I), UVA + UVB irradiation, and bacterial lipopolysaccharide (LPS) were used. We demonstrated differential modulation of inflammatory responses in keratinocytes at signal transduction, gene transcription, and protein synthesis levels as a function of PP chemical structure, the pro-inflammatory trigger used, and PP interaction with intracellular detoxifying systems. The PPs remarkably inhibited constitutive, LPS- and T/I-induced but not TGFalpha-induced ERK phosphorylation. They also suppressed NFkappaB activation by LPS and T/I. Verbascoside and quercetin invariably impaired EGFR phosphorylation and UV-associated aryl hydrocarbon receptor (AhR)-mediated signaling, while rutin, polydatin and resveratrol did not affect EGFR phosphorylation and further activated AhR machinery in UV-exposed keratinocytes. In general, PPs down-regulated gene expression of pro-inflammatory cytokines/enzymes, except significant up-regulation of IL-8 observed under stimulation with TGFalpha. Both spontaneous and T/I-induced release of IL-8 and IP-10 was suppressed, although 50 {mu}M resveratrol and polydatin up-regulated IL-8. At this concentration, resveratrol activated both gene expression and de novo synthesis of IL-8 and AhR-mediated mechanisms were involved. We conclude that PPs differentially modulate the inflammatory response of human keratinocytes through distinct signal transduction pathways, including AhR and EGFR. - Graphical abstract: Display Omitted Highlights: > Effects of plant polyphenols on inflammatory responses in human keratinocytes. > Inflammatory stimuli used: TGFalpha, TNFalpha+IFNgamma, UVA+UVB, and LPS. > Inflammatory pathways connected with NFB, ERK1/2, EGFR, and AhR were investigated. > Plant polyphenols, flavonoids, stilbenoids, and phenylpropanoids, were studied. > Modulation of inflammation depends on phenolic core structure and glycosylation.

  11. Call for Papers Special Issue on Integrated Decision Support Systems

    E-Print Network [OSTI]

    Winckler, Marco Antonio Alba

    ); integration of decisions across both forward supply chains and reverse logistics; integration of decisions

  12. Research Focus A general mechanism for decision-making in the

    E-Print Network [OSTI]

    Newsome, William

    Research Focus A general mechanism for decision-making in the human brain? Alan E. Rorie by flipping coins, rolling dice or drawing straws. Ideally, jurors attend carefully and equally to all sources-making in human subjects. Functional MRI data obtained while subjects categorized visual images suggest

  13. Human System Simulation in Support of Human Performance Technical Basis at NPPs

    SciTech Connect (OSTI)

    David Gertman; Katya Le Blanc; alan mecham; william phoenix; Magdy Tawfik; Jeffrey Joe

    2010-06-01

    This paper focuses on strategies and progress toward establishing the Idaho National Laboratory’s (INL’s) Human Systems Simulator Laboratory at the Center for Advanced Energy Studies (CAES), a consortium of Idaho State Universities. The INL is one of the National Laboratories of the US Department of Energy. One of the first planned applications for the Human Systems Simulator Laboratory is implementation of a dynamic nuclear power plant simulation (NPP) where studies of operator workload, situation awareness, performance and preference will be carried out in simulated control rooms including nuclear power plant control rooms. Simulation offers a means by which to review operational concepts, improve design practices and provide a technical basis for licensing decisions. In preparation for the next generation power plant and current government and industry efforts in support of light water reactor sustainability, human operators will be attached to a suite of physiological measurement instruments and, in combination with traditional Human Factors Measurement techniques, carry out control room tasks in simulated advanced digital and hybrid analog/digital control rooms. The current focus of the Human Systems Simulator Laboratory is building core competence in quantitative and qualitative measurements of situation awareness and workload. Of particular interest is whether introduction of digital systems including automated procedures has the potential to reduce workload and enhance safety while improving situation awareness or whether workload is merely shifted and situation awareness is modified in yet to be determined ways. Data analysis is carried out by engineers and scientists and includes measures of the physical and neurological correlates of human performance. The current approach supports a user-centered design philosophy (see ISO 13407 “Human Centered Design Process for Interactive Systems, 1999) wherein the context for task performance along with the requirements of the end-user are taken into account during the design process and the validity of design is determined through testing of real end users

  14. Risk perception & strategic decision making :general insights, a framework, and specific application to electricity generation using nuclear energy.

    SciTech Connect (OSTI)

    Brewer, Jeffrey D.

    2005-11-01

    The objective of this report is to promote increased understanding of decision making processes and hopefully to enable improved decision making regarding high-consequence, highly sophisticated technological systems. This report brings together insights regarding risk perception and decision making across domains ranging from nuclear power technology safety, cognitive psychology, economics, science education, public policy, and neural science (to name a few). It forms them into a unique, coherent, concise framework, and list of strategies to aid in decision making. It is suggested that all decision makers, whether ordinary citizens, academics, or political leaders, ought to cultivate their abilities to separate the wheat from the chaff in these types of decision making instances. The wheat includes proper data sources and helpful human decision making heuristics; these should be sought. The chaff includes ''unhelpful biases'' that hinder proper interpretation of available data and lead people unwittingly toward inappropriate decision making ''strategies''; obviously, these should be avoided. It is further proposed that successfully accomplishing the wheat vs. chaff separation is very difficult, yet tenable. This report hopes to expose and facilitate navigation away from decision-making traps which often ensnare the unwary. Furthermore, it is emphasized that one's personal decision making biases can be examined, and tools can be provided allowing better means to generate, evaluate, and select among decision options. Many examples in this report are tailored to the energy domain (esp. nuclear power for electricity generation). The decision making framework and approach presented here are applicable to any high-consequence, highly sophisticated technological system.

  15. Making Compressed Air System Decisions 

    E-Print Network [OSTI]

    Porri, R. E.

    1996-01-01

    stream_source_info ESL-IE-96-04-32.pdf.txt stream_content_type text/plain stream_size 5121 Content-Encoding ISO-8859-1 stream_name ESL-IE-96-04-32.pdf.txt Content-Type text/plain; charset=ISO-8859-1 MAKING COMPRESSED AIR... SYSTEM DECISIONS Richard E. Porri Product Manager ABSTRACT This paper presents a decision making process that will pennit the design, installation and operation ofa high efficiency and reliable compressed air system. The design of a compressed air...

  16. Initial Decision and Risk Analysis

    SciTech Connect (OSTI)

    Engel, David W.

    2012-02-29

    Decision and Risk Analysis capabilities will be developed for industry consideration and possible adoption within Year 1. These tools will provide a methodology for merging qualitative ranking of technology maturity and acknowledged risk contributors with quantitative metrics that drive investment decision processes. Methods and tools will be initially introduced as applications to the A650.1 case study, but modular spreadsheets and analysis routines will be offered to industry collaborators as soon as possible to stimulate user feedback and co-development opportunities.

  17. Technology Decisions Under Architectural Uncertainty: Informing Investment Decisions Through Tradespace Exploration

    E-Print Network [OSTI]

    de Weck, Olivier L.

    Technology Decisions Under Architectural Uncertainty: Informing Investment Decisions Through this architectural uncertainty, it is difficult to define the value proposition of technology investments. This paper proposes a method for evaluating technology across a tradespace defined by architectural decisions. Main

  18. Markov Modeling with Soft Aggregation for Safety and Decision Analysis

    SciTech Connect (OSTI)

    COOPER,J. ARLIN

    1999-09-01

    The methodology in this report improves on some of the limitations of many conventional safety assessment and decision analysis methods. A top-down mathematical approach is developed for decomposing systems and for expressing imprecise individual metrics as possibilistic or fuzzy numbers. A ''Markov-like'' model is developed that facilitates combining (aggregating) inputs into overall metrics and decision aids, also portraying the inherent uncertainty. A major goal of Markov modeling is to help convey the top-down system perspective. One of the constituent methodologies allows metrics to be weighted according to significance of the attribute and aggregated nonlinearly as to contribution. This aggregation is performed using exponential combination of the metrics, since the accumulating effect of such factors responds less and less to additional factors. This is termed ''soft'' mathematical aggregation. Dependence among the contributing factors is accounted for by incorporating subjective metrics on ''overlap'' of the factors as well as by correspondingly reducing the overall contribution of these combinations to the overall aggregation. Decisions corresponding to the meaningfulness of the results are facilitated in several ways. First, the results are compared to a soft threshold provided by a sigmoid function. Second, information is provided on input ''Importance'' and ''Sensitivity,'' in order to know where to place emphasis on considering new controls that may be necessary. Third, trends in inputs and outputs are tracked in order to obtain significant information% including cyclic information for the decision process. A practical example from the air transportation industry is used to demonstrate application of the methodology. Illustrations are given for developing a structure (along with recommended inputs and weights) for air transportation oversight at three different levels, for developing and using cycle information, for developing Importance and Sensitivity measures for soil aggregation, for developing dependence methodology, for constructing early alert logic, for tracking trends, for relating the Markov model to other (e.g., Reason) models, for developing and demonstrating rudimentary laptop software, and for developing an input/output display methodology.

  19. Human machine collaborative decision making in a complex optimization system

    E-Print Network [OSTI]

    Malasky, Jeremy S

    2005-01-01

    Numerous complex real-world applications are either theoretically intractable or unable to be solved in a practical amount of time. Researchers and practitioners are forced to implement heuristics in solving such problems ...

  20. Learned Human-in-the-Loop Decision Making

    E-Print Network [OSTI]

    Basso, Brandon

    2012-01-01

    A multi-agent UAV mission planningUnmanned Autonomous System. 4 UAV Unmanned Aerial Vehicle.Results in Cooperative UAV Control”. In: Proceedings of the

  1. Human-Automation Path Planning Optimization and Decision Support

    E-Print Network [OSTI]

    Cummings, M.L.

    2011-01-01

    Path planning is a problem encountered in multiple domains, including unmanned vehicle control, air traffic control, and future exploration missions to the Moon and Mars. Due to the voluminous and complex nature of the ...

  2. AUTOMATIC DOCUMENT CLASSIFICATION BASED ON EXPERT HUMAN DECISIONS

    E-Print Network [OSTI]

    Cahn, D.F.

    2010-01-01

    References 1. G. Salton, Automatic Information Organizationstatistical output from automatic document classifier. (Test26, 19,77 LBL-6164 r~ \\ AUTOMATIC DOCUMENT C LASsiFICA TION

  3. Learned Human-in-the-Loop Decision Making

    E-Print Network [OSTI]

    Basso, Brandon

    2012-01-01

    An Autonomous Unmanned Aerial Vehicle System for Sensing andsystem for unmanned aerial vehicles executing collaborativeControl of Unmanned Aerial Vehicle Collaborative Sens- ing

  4. Politically rational foreign policy decision-making 

    E-Print Network [OSTI]

    Kent, Charles Todd

    2006-10-30

    This dissertation is an analysis of how presidents make foreign policy decisions. Rather than explaining foreign policy decisions by focusing on individuals or institutions, I stress the role of political pressures and ...

  5. |Research Focus Statistical decision theory and evolution

    E-Print Network [OSTI]

    Maloney, Laurence T.

    |Research Focus Statistical decision theory and evolution Laurence T. Maloney Department recent articles by Geisler and Diehl use Bayesian statistical decision theory to model the co, an advantage that ultimately translates into `reproductive success'. The balance between predator and prey

  6. Corporate decision analysis : an engineering approach

    E-Print Network [OSTI]

    Tang, Victor, Ph.D. Massachusetts Institute of Technology

    2006-01-01

    We explore corporate decisions and their solutions under uncertainty using engineering methods. Corporate decisions tend to be complex; they are interdisciplinary and defy programmable solutions. To address these challenges, ...

  7. Systems analysis of major consumer energy decisions

    E-Print Network [OSTI]

    Sisler, Nicholas Daniel

    2011-01-01

    American consumers make a number of decisions that significantly impact their energy use. Some of the most important of these decisions were identified and analyzed for the purpose of including them in a Consumer Energy ...

  8. Electricity Generation and Emissions Reduction Decisions

    E-Print Network [OSTI]

    Electricity Generation and Emissions Reduction Decisions under Policy Uncertainty: A General;1 Electricity Generation and Emissions Reduction Decisions under Policy Uncertainty: A General Equilibrium Analysis Jennifer Morris* , Mort Webster* and John Reilly* Abstract The electric power sector, which

  9. Factors influencing German private equity investment in US real estate

    E-Print Network [OSTI]

    Paelmo, Kay L. (Kay Lee), 1977-

    2003-01-01

    This thesis identifies and ranks in order of importance the key factors influencing high net-worth German investors' decisions about US real estate private equity investments. Through research and in-depth interviews with ...

  10. Automatic Decision Detection in Meeting Speech 

    E-Print Network [OSTI]

    Hsueh, Pei-Yun; Moore, Johanna D.

    2010-11-01

    are not sufficient for locating decision points from meeting archives. In this paper, we present the AMI DecisionDetector, a system that automatically detects and highlights where the decision-related conversations are. In this paper, we apply the models developed...

  11. Multiple Criteria Decision Support by Evolutionary Computation

    E-Print Network [OSTI]

    Zitzler, Eckart

    1 Multiple Criteria Decision Support by Evolutionary Computation Marco Laumanns, Eckart Zitzler difficult or impossible. In addition, they can handle multiple criteria simultaneously, being able to gener of these variables form the set of decision alternatives. The criteria to judge each decision relate to the output

  12. Decision analysis of polluted sites -- A fuzzy set approach

    SciTech Connect (OSTI)

    Mohamed, A.M.O.; Cote, K.

    1999-07-01

    A decision analysis based model (DAPS 1.0, Decision Analysis of Polluted Sites) has been developed to evaluate risks that polluted sites might pose to human health. Pollutants present in soils and sediments can potentially migrate from source to receptor(s), via different pathways. in the developed model, pathways are simulated via transport models (i.e., groundwater transport model, runoff-erosion model, air diffusion model, and sediment diffusion, and resuspension model in water bodies). Humans can be affected by pollutant migration through land and water use. health risks can arise from ingestion of and dermal contact with polluted water and soil, as well as through inhalation of polluted air. Quantitative estimates of risks are calculated for both carcinogenic and non-carcinogenic pollutants. Being very heterogeneous, soil and sediment systems are characterized by uncertain parameters. Concepts of fuzzy set theory have been adopted to account for uncertainty in the input parameters which are represented by fuzzy numbers. An inference model using fuzzy logic has been constructed for reasoning in the decision analysis.

  13. Federal Aviation Administration Human Factors Team

    E-Print Network [OSTI]

    Ladkin, Peter B.

    a study to evaluate the flightcrew/flight deck automation interfaces of current generation transport Commercial Airplane Group, British Airways, Crew System Ergonomics Information Analysis Center, Direction

  14. Simulation of human factors for material safety

    SciTech Connect (OSTI)

    Koehler, A. C. (Andrew C.); Gonzales-Lujan, J. M. (Johnell M.); Tompkins, G. (George); Burnside, R. J. (Robert J.); Kornreich, D. E. (Drew E.)

    2003-01-01

    The D-1 (Statistical Sciences) and D-2 (Stockpile Complex Modeling and Analysis) groups frequently collaborate to analyze production capabilities at Los Alamos National Laboratory. The facilities in question run the gamut from traditional machining to the fabrication of Plutonium components. This paper documents our efforts to extend our modeling capabilities from traditional discrete event simulation modeling to include agent based models.

  15. Human Factors Aspects of Advanced Process Control 

    E-Print Network [OSTI]

    Shaw, J. A.

    1986-01-01

    ASPECTS OF ADVANCED PRO?CESS CONTROL John A. Shaw Combustion Engineering Taylor Instrument Division Rochester, New York ABSTRACT Energy conservation practices, such as heat recovery and integration, require that many chemical and related... processes use advanced control systems. Many of the more advanced process control strategies and algorithms can cause operator confusion, leading to incorrect operator actions and negating the advantages of the advanced control. Ifthe operator makes a...

  16. Nuclear Power - Control, Reliability and Human Factors 

    E-Print Network [OSTI]

    2011-01-01

    Reliability K s e n i i a Sapoz h n i k o v a and Roald Tayma n o v D.I.Mendeleyev Institute for Metrology, Russia 1. Introduction At present, a great number of embedded sens o r devi c es provi d e monito r i n g of operat i n g condi t io n... s and state of equi p me n t , includ i n g nucle a r react o r s of power plant s . The metrol o gi c a l reliab i li t y of meas uri n g instrum e n t s built in equi p me n t deter mi n e s the valid i t y of measure me nt infor ma t i o n . The qualit y...

  17. Fehlermanagement System Fehlerkultur Fehlermanagement Human Factors

    E-Print Network [OSTI]

    Manstein, Dietmar J.

    Fehlermanagement Qualitätsmethode Primärnutzen Präventiv SRA Strukturierte Risikoanalyse Risikoreduzierung FMEA Identifikationsphase (S1) Definitionsphase (S2) SRA Machbarkeitsphase (S3) Entwicklungs- Design und Testphase (S4) FMEA Zulassungsphase (S5) Prozess- FMEA Produktionseinführungsphase (S6) Fehlermanagement-System #12;22. April 2013 11

  18. Aviation Human Factors Division Institute of Aviation

    E-Print Network [OSTI]

    of millions of miles of wires and thousands of individual generators" (Overbye, 2000, p. 220). To operate is restructuring to allow non-utility generators, brokers, marketers, and load aggregators to share for the many new market participants and protect the system from costly failures. Some researchers

  19. Human Factors Analysis of Predator B Crash

    E-Print Network [OSTI]

    Carrigan, Geoff

    2008-06-10

    The 2006 crash of a Predator B in Arizona has prompted a great amount of scrutiny into Unmanned Arial System (UAS) operations. The direct cause of the Predator crash can be tied to an initial failure of the displays and a ...

  20. Executive decision making processes and outcomes : structure and robustness

    E-Print Network [OSTI]

    Chacon, Vince

    2003-01-01

    Uncertainty in the decision making environment complicates the decision making process because future events may change the effect of a particular decision or series of decisions. This thesis explores the possibility of ...

  1. Insulin-Like Growth Factor-Type 1 Receptor Inhibitor NVP-AEW541 Enhances Radiosensitivity of PTEN Wild-Type but Not PTEN-Deficient Human Prostate Cancer Cells

    SciTech Connect (OSTI)

    Isebaert, Sofie F.; Swinnen, Johannes V.; McBride, William H.; Haustermans, Karin M.

    2011-09-01

    Purpose: During the past decade, many clinical trials with both monoclonal antibodies and small molecules that target the insulin-like growth factor-type 1 receptor (IGF-1R) have been launched. Despite the important role of IGF-1R signaling in radioresistance, studies of such agents in combination with radiotherapy are lagging behind. Therefore, the aim of this study was to investigate the effect of the small molecule IGF-1R kinase inhibitor NVP-AEW541 on the intrinsic radioresistance of prostate cancer cells. Methods and Materials: The effect of NVP-AEW541 on cell proliferation, cell viability, IGF-1R signaling, radiosensitivity, cell cycle distribution, and double strand break repair was determined in three human prostate cancer cell lines (PC3, DU145, 22Rv1). Moreover, the importance of the PTEN pathway status was explored by means of transfection experiments with constitutively active Akt or inactive kinase-dead Akt. Results: NVP-AEW541 inhibited cell proliferation and decreased cell viability in a time-and dose-dependent manner in all three cell lines. Radiosensitization was observed in the PTEN wild-type cell lines DU145 and 22Rv1 but not in the PTEN-deficient PC3 cell line. NVP-AEW541-induced radiosensitization coincided with downregulation of phospho-Akt levels and high levels of residual double strand breaks. The importance of PTEN status in the radiosensitization effect was confirmed by transfection experiments with constitutively active Akt or inactive kinase-dead Akt. Conclusions: NVP-AEW541 enhances the effect of ionizing radiation in PTEN wild-type, but not in PTEN-deficient, prostate cancer cells. Proper patient selection based on the PTEN status of the tumor will be critical to the achievement of optimal results in clinical trials in which the combination of radiotherapy and this IGF-1R inhibitor is being explored.

  2. Decision making based on optical excitation transfer via near-field interactions between quantum dots

    SciTech Connect (OSTI)

    Naruse, Makoto, E-mail: naruse@nict.go.jp [Photonic Network Research Institute, National Institute of Information and Communications Technology, 4-2-1 Nukui-kita, Koganei, Tokyo 184-8795 (Japan); Nomura, Wataru; Ohtsu, Motoichi [Department of Electrical Engineering and Information Systems, Graduate School of Engineering, The University of Tokyo, 2-11-16 Yayoi, Bunkyo-ku, Tokyo 113-8656 (Japan); Aono, Masashi [Earth-Life Science Institute, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguru-ku, Tokyo 152-8550 (Japan); PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi-shi, Saitama 332-0012 (Japan); Sonnefraud, Yannick; Drezet, Aurélien; Huant, Serge [Université Grenoble Alpes, Inst. NEEL, F-38000 Grenoble (France); CNRS, Inst. NEEL, F-38042 Grenoble (France); Kim, Song-Ju [WPI Center for Materials Nanoarchitectonics, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044 (Japan)

    2014-10-21

    Optical near-field interactions between nanostructured matters, such as quantum dots, result in unidirectional optical excitation transfer when energy dissipation is induced. This results in versatile spatiotemporal dynamics of the optical excitation, which can be controlled by engineering the dissipation processes and exploited to realize intelligent capabilities such as solution searching and decision making. Here, we experimentally demonstrate the ability to solve a decision making problem on the basis of optical excitation transfer via near-field interactions by using colloidal quantum dots of different sizes, formed on a geometry-controlled substrate. We characterize the energy transfer behavior due to multiple control light patterns and experimentally demonstrate the ability to solve the multi-armed bandit problem. Our work makes a decisive step towards the practical design of nanophotonic systems capable of efficient decision making, one of the most important intellectual attributes of the human brain.

  3. Eielson Air Force Base operable unit 2 and other areas record of decision

    SciTech Connect (OSTI)

    Lewis, R.E.; Smith, R.M.

    1994-10-01

    This decision document presents the selected remedial actions and no action decisions for Operable Unit 2 (OU2) at Eielson Air Force Base (AFB), Alaska, chosen in accordance with state and federal regulations. This document also presents the decision that no further action is required for 21 other source areas at Eielson AFB. This decision is based on the administrative record file for this site. OU2 addresses sites contaminated by leaks and spills of fuels. Soils contaminated with petroleum products occur at or near the source of contamination. Contaminated subsurface soil and groundwater occur in plumes on the top of a shallow groundwater table that fluctuates seasonally. These sites pose a risk to human health and the environment because of ingestion, inhalation, and dermal contact with contaminated groundwater. The purpose of this response is to prevent current or future exposure to the contaminated groundwater, to reduce further contaminant migration into the groundwater, and to remediate groundwater.

  4. Screening Assessment of Potential Human-Health Risk from Future Natural-Gas Drilling Near Project Rulison in Western Colorado

    SciTech Connect (OSTI)

    Daniels Jeffrey I.,Chapman Jenny B.

    2012-01-01

    The Project Rulison underground nuclear test was conducted in 1969 at a depth of 8,400 ft in the Williams Fork Formation of the Piceance Basin, west-central Colorado (Figure 1). The U.S. Department of Energy Office of Legacy Management (LM) is the steward of the site. Their management is guided by data collected from past site investigations and current monitoring, and by the results of calculations of expected behavior of contaminants remaining in the deep subsurface. The purpose of this screening risk assessment is to evaluate possible health risks from current and future exposure to Rulison contaminants so the information can be factored into LM's stewardship decisions. For example, these risk assessment results can inform decisions regarding institutional controls at the site and appropriate monitoring of nearby natural-gas extraction activities. Specifically, the screening risk analysis can provide guidance for setting appropriate action levels for contaminant monitoring to ensure protection of human health.

  5. Supply chain planning decisions under demand uncertainty

    E-Print Network [OSTI]

    Huang, Yanfeng Anna

    2008-01-01

    Sales and operational planning that incorporates unconstrained demand forecasts has been expected to improve long term corporate profitability. Companies are considering such unconstrained demand forecasts in their decisions ...

  6. 5(b)/9(c) Record of Decision

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Revised Policy on Determining Net Requirements of Pacific Northwest Utility Customers Under Sections 5(b)(1) and 9(c) of the Northwest Power Act Administrator's Record of Decision...

  7. C H A P T E R From Experienced Utility to Decision Utility

    E-Print Network [OSTI]

    Berridge, Kent

    C H A P T E R 18c0018 From Experienced Utility to Decision Utility Kent C. Berridge and John P. O'Doherty O U T L I N E Introduction 325 Experienced Utility 325 Brain Mechanisms of Sensory Pleasure: Window into Experienced Utility Generators 326 Experienced Utility: Neuroimaging Brain Activations in Humans 327 Relating

  8. Human energy

    E-Print Network [OSTI]

    Sawyer, Suzana

    2010-01-01

    This is the power of human energy that Chevron neverExperience the power of ‘‘Human Energy’’: S. Sawyer (&)s voice returns: ‘‘This is the power of human energy. ’’ In

  9. Digital Human Modeling for Palpatory Medical Training with Haptic Feedback

    E-Print Network [OSTI]

    Williams II, Robert L.

    Modeling for Applied Ergonomics and Human Factors Engineering, Chapter 48, ISBN 978- 0-8058-5646. #12 Evaluation Results

  10. Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.

    E-Print Network [OSTI]

    Yang, Sun; Irani, Kaikobad; Heffron, Susan E; Jurnak, Frances; Meyskens, Frank L Jr

    2005-01-01

    changes induced by resveratrol in human melanoma. MolN, Dannenberg AJ. Resveratrol inhibits cyclooxygenase-2S, Pezzuto JM, Kong AN. Resveratrol inhibits phorbol ester

  11. Human Driver Model for SmartAHS

    E-Print Network [OSTI]

    Delorme, Delphine; Song, Bongsob

    2001-01-01

    the Human Factors field (Rockwell 1988, Bhises et al.1986,Amsterdam, pp. 91-100. Rockwell, T. H. , (1988) Spare visual

  12. A mid-layer model for human reliability analysis : understanding the cognitive causes of human failure events.

    SciTech Connect (OSTI)

    Shen, Song-Hua; Chang, James Y. H.; Boring,Ronald L.; Whaley, April M.; Lois, Erasmia; Hendrickson, Stacey M. Langfitt; Oxstrand, Johanna H.; Forester, John Alan; Kelly, Dana L.; Mosleh, Ali

    2010-03-01

    The Office of Nuclear Regulatory Research (RES) at the US Nuclear Regulatory Commission (USNRC) is sponsoring work in response to a Staff Requirements Memorandum (SRM) directing an effort to establish a single human reliability analysis (HRA) method for the agency or guidance for the use of multiple methods. As part of this effort an attempt to develop a comprehensive HRA qualitative approach is being pursued. This paper presents a draft of the method's middle layer, a part of the qualitative analysis phase that links failure mechanisms to performance shaping factors. Starting with a Crew Response Tree (CRT) that has identified human failure events, analysts identify potential failure mechanisms using the mid-layer model. The mid-layer model presented in this paper traces the identification of the failure mechanisms using the Information-Diagnosis/Decision-Action (IDA) model and cognitive models from the psychological literature. Each failure mechanism is grouped according to a phase of IDA. Under each phase of IDA, the cognitive models help identify the relevant performance shaping factors for the failure mechanism. The use of IDA and cognitive models can be traced through fault trees, which provide a detailed complement to the CRT.

  13. Algorithmic Decision Theory and the Smart Grid

    E-Print Network [OSTI]

    surmount concomitant challenges: -Interoperating/distributed decision makers and decision-making devices. of Energy to the SIAM Science Policy Committee, October 2009. ·Others benefit from a presentation by Massoud ·Today's electric power systems have grown up incrementally and haphazardly ­ they were not designed from

  14. Phase Transition Behavior: from Decision to Optimization

    E-Print Network [OSTI]

    Walsh, Toby

    Phase Transition Behavior: from Decision to Optimization John Slaney Australian National University, therefore, that insights into decision problems gained by studying phase transition behavior could be useful is a rapid increase in problem diÆculty. The random 2-Sat transition is continuous (or \\2nd order

  15. Evaluation of information bundles in engineering decisions 

    E-Print Network [OSTI]

    Bakir, Niyazi Onur

    2004-11-15

    problems. In static insurance decisions, we analyze the case where the decision maker gathers information about the severity of the risk events and perform ranking of information bundles in a speci?c class. In dynamic insurance problems, we make a...

  16. Decision under uncertainty with limited information

    E-Print Network [OSTI]

    Nikolaidis, Efstratios

    own land in oil rich region · Can sell it for $18,500 or drill · Drilling costs $70,000 · If no oil and countries depends on the ability of their leaders to make good decisions. #12;4 Example Drill for oil · You is found land becomes worthless · Sell or drill? #12;5 Decision tree: Graphical representation of sequence

  17. Human dimensions in cyber operations research and development priorities.

    SciTech Connect (OSTI)

    Forsythe, James Chris; Silva, Austin Ray; Stevens-Adams, Susan Marie; Bradshaw, Jeffrey

    2012-11-01

    Within cyber security, the human element represents one of the greatest untapped opportunities for increasing the effectiveness of network defenses. However, there has been little research to understand the human dimension in cyber operations. To better understand the needs and priorities for research and development to address these issues, a workshop was conducted August 28-29, 2012 in Washington DC. A synthesis was developed that captured the key issues and associated research questions. Research and development needs were identified that fell into three parallel paths: (1) human factors analysis and scientific studies to establish foundational knowledge concerning factors underlying the performance of cyber defenders; (2) development of models that capture key processes that mediate interactions between defenders, users, adversaries and the public; and (3) development of a multi-purpose test environment for conducting controlled experiments that enables systems and human performance measurement. These research and development investments would transform cyber operations from an art to a science, enabling systems solutions to be engineered to address a range of situations. Organizations would be able to move beyond the current state where key decisions (e.g. personnel assignment) are made on a largely ad hoc basis to a state in which there exist institutionalized processes for assuring the right people are doing the right jobs in the right way. These developments lay the groundwork for emergence of a professional class of cyber defenders with defined roles and career progressions, with higher levels of personnel commitment and retention. Finally, the operational impact would be evident in improved performance, accompanied by a shift to a more proactive response in which defenders have the capacity to exert greater control over the cyber battlespace.

  18. Enhancing Multi-Agent Based Simulation with Human-Agents Interactive Spatial Behaviour

    E-Print Network [OSTI]

    Chen, Yee Ming; Shiu, Hung-Ming

    2009-01-01

    We are exploring the enhancement of models of agent behaviour with more "human-like" decision making strategies than are presently available. Our motivation is to developed with a view to as the decision analysis and support for electric taxi company under the mission of energy saving and reduction of CO2, in particular car-pool and car-sharing management policies. In order to achieve the object of decision analysis for user, we provide a human-agents interactive spatial behaviour to support user making decision real time. We adopt passenger average waiting time and electric taxi average idle time as the performance measures and decision support fro electric taxi company. Finally, according to the analysis result, we demonstrate that our multi-agent simulation and GUI can help users or companies quickly make a quality and accurate decision to reduce the decision-making cost and time.

  19. Decision making under uncertainty: An investigation into the application of formal decision-making methods to safety issue decisions

    SciTech Connect (OSTI)

    Bohn, M P [Sandia National Labs., Albuquerque, NM (United States)] [Sandia National Labs., Albuquerque, NM (United States)

    1992-12-01

    As part of the NRC-sponsored program to study the implications of Generic Issue 57, Effects of Fire Protection System Actuation on Safety-Related Equipment,'' a subtask was performed to evaluate the applicability of formal decision analysis methods to generic issues cost/benefit-type decisions and to apply these methods to the GI-57 results. In this report, the numerical results obtained from the analysis of three plants (two PWRs and one BWR) as developed in the technical resolution program for GI-57 were studied. For each plant, these results included a calculation of the person-REM averted due to various accident scenarios and various proposed modifications to mitigate the accident scenarios identified. These results were recomputed to break out the benefit in terms of contributions due to random event scenarios, fire event scenarios, and seismic event scenarios. Furthermore, the benefits associated with risk (in terms of person-REM) averted from earthquakes at three different seismic ground motion levels were separately considered. Given this data, formal decision methodologies involving decision trees, value functions, and utility functions were applied to this basic data. It is shown that the formal decision methodology can be applied at several different levels. Examples are given in which the decision between several retrofits is changed from that resulting from a simple cost/benefit-ratio criterion by virtue of the decision-makinger's expressed (and assumed) preferences.

  20. Geography: Critical Factors in the Analysis of Complex Systems

    E-Print Network [OSTI]

    Welch, Ivan

    2012-05-31

    is needed for a systematic study of geostrategic issues for the purposes of policy making and strategic planning. Geographic scale, its impact on human action and incorporation into human culture, is pervasive. These factors of geography and their variables...

  1. The human activity of visualization

    E-Print Network [OSTI]

    Wright, Dawn Jeannine

    Griffin et al 2006 #12;Human-Computer Interaction: Software of the Mind each user has a setThe human activity of visualization cultural and psychological factors in representation; Gibbon 1998; Marcus 2000) conventions and metaphors of Westerners may not hold worldwide colors

  2. The Internet of Decisions There is a need to change from systems thinking to infrastructural thinking about decision

    E-Print Network [OSTI]

    Bisdorff, Raymond

    decision fusion and aiding methodologies especially for spatial data handling, and easily scalable, Internet, Decision Fusion, Decision Making and Aiding Practice, Multiple Criteria Decision Aid, Decision Star et al. (1996) and Edwards et al. (2007) we may recognize that DSSI emerges as: an embodiment

  3. Effective Design And Use Of Computer Decision Models.

    E-Print Network [OSTI]

    Fuerst, William L.

    1984-03-01

    of decision models such as simulation have not been demonstrated. This paper looks at recent literature regarding decision model deficiencies, evaluates selected financial simulation model packages, and suggests design needs for expanding the use of decision...

  4. EIS-0473: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    EIS-0473: Record of Decision EIS-0473: Record of Decision W.A. Parish Post-Combustion CO2 Capture and Sequestration Project, Fort Bend County, Texas DOE announces its decision to...

  5. DOE Secretarial Memorandum on Improved Decision Making through...

    Office of Environmental Management (EM)

    Decision Making through the Integration of Program and Project Management with National Environmental Policy Act Compliance DOE Secretarial Memorandum on Improved Decision Making...

  6. Reduction of Transient Particulate Matter Spikes with Decision...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Transient Particulate Matter Spikes with Decision Tree Based Control Reduction of Transient Particulate Matter Spikes with Decision Tree Based Control Using a non-parametric...

  7. Risk Analysis and Decision-Making Under Uncertainty: A Strategy...

    Office of Environmental Management (EM)

    Risk Analysis and Decision-Making Under Uncertainty: A Strategy and its Applications Risk Analysis and Decision-Making Under Uncertainty: A Strategy and its Applications Ming Ye...

  8. Statement from Energy Secretary Bodman on OPEC's Decision to...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Statement from Energy Secretary Bodman on OPEC's Decision to Cut Crude Oil Production Statement from Energy Secretary Bodman on OPEC's Decision to Cut Crude Oil Production October...

  9. Procuring Solar Energy: A Guide for Federal Facility Decision...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Procuring Solar Energy: A Guide for Federal Facility Decision Makers, Appendix B, September 2010 Procuring Solar Energy: A Guide for Federal Facility Decision Makers, Appendix B,...

  10. Record of Decision for the Uranium Leasing Program Programmatic...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision for the Uranium Leasing Program Programmatic Environmental Impact Statement Record of Decision for the Uranium Leasing Program Programmatic Environmental Impact...

  11. Cellular Decision Making and Biological Noise: From Microbes to Mammals

    E-Print Network [OSTI]

    Balazsi, Gabor

    Cellular decision making is the process whereby cells assume different, functionally important and heritable fates without an associated genetic or environmental difference. Such stochastic cell fate decisions generate ...

  12. Assessment of New Approaches in Geothermal Exploration Decision...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    approaches were investigated to develop a best-practices methodology for objective geothermal exploration decision making at a given location, including gono-go decision points...

  13. 15.060 Data, Models, and Decisions, Fall 2002

    E-Print Network [OSTI]

    Freund, Robert Michael

    Introduces students to the basic tools in using data to make informed management decisions. Covers introductory probability, decision analysis, basic statistics, regression, simulation, linear and nonlinear optimization, ...

  14. Probabilistic Modeling and Phase 2 Decision Making at the West...

    Office of Environmental Management (EM)

    and Phase 2 Decision Making at the West Valley Demonstration Project and the Western New York Nuclear Service Center Probabilistic Modeling and Phase 2 Decision Making at the...

  15. Preferences, Information, and Group Decision Making 

    E-Print Network [OSTI]

    Espinoza, Alejandro

    2009-05-15

    This study will examine how the structure of preferences of group members in a decision-making group, as well as the information they have, affects the collection and the processing of information by individual members of ...

  16. Total cost model for making sourcing decisions

    E-Print Network [OSTI]

    Morita, Mark, M.B.A. Massachusetts Institute of Technology

    2007-01-01

    This thesis develops a total cost model based on the work done during a six month internship with ABB. In order to help ABB better focus on low cost country sourcing, a total cost model was developed for sourcing decisions. ...

  17. Engineering Advancement Trust 2012 Funding Decisions

    E-Print Network [OSTI]

    Saskatchewan, University of

    Engineering Advancement Trust 2012 Funding Decisions Prepared The College of Engineering is committed to ensuring the quality of our undergraduate programs. The generous contributions from alumni into the Engineering Advancement Trust (EAT) continue

  18. Management Forecast Quality and Capital Investment Decisions

    E-Print Network [OSTI]

    Goodman, Theodore H.

    Corporate investment decisions require managers to forecast expected future cash flows from potential investments. Although these forecasts are a critical component of successful investing, they are not directly observable ...

  19. Technology and public participation in environmental decisions

    E-Print Network [OSTI]

    Yao, Basilia Wang

    2006-01-01

    Since 1970, the National Environmental Policy Act (NEPA) has served as the main instrument for analyzing the environmental impacts of federal agency decisions and providing the public with opportunities to participate in ...

  20. Information, decision-making and health

    E-Print Network [OSTI]

    Abaluck, Jason T

    2011-01-01

    This thesis consists of three essays on information, decision-making and health. All three concern the relationship between the choices consumers would make if they were "fully informed" in an appropriate sense and the ...

  1. Rock Slopes from Mechanics to Decision Making

    E-Print Network [OSTI]

    Einstein, Herbert H.

    Rock slope instabilities are discussed in the context of decision making for risk assessment and management. Hence, the state of the slope and possible failure mechanism need to be defined first. This is done with geometrical ...

  2. Moon: the 8th continent HUMAN SPACEFLIGHT 2025

    E-Print Network [OSTI]

    Rathbun, Julie A.

    to be done to develop models that can accu- rately predict the likely environmental impact interest and generates the support of key stakeholders and decision makers." The vision "In 2025, Europe as preparation for the robotic and human exploration of the Solar System. Human Spaceflight: The Story So Far 11

  3. Parallel object-oriented decision tree system

    DOE Patents [OSTI]

    Kamath; Chandrika (Dublin, CA), Cantu-Paz; Erick (Oakland, CA)

    2006-02-28

    A data mining decision tree system that uncovers patterns, associations, anomalies, and other statistically significant structures in data by reading and displaying data files, extracting relevant features for each of the objects, and using a method of recognizing patterns among the objects based upon object features through a decision tree that reads the data, sorts the data if necessary, determines the best manner to split the data into subsets according to some criterion, and splits the data.

  4. Linking Humans and Systems in Nuclear Power

    SciTech Connect (OSTI)

    Jacques Hugo

    2013-02-01

    Traditional engineering methods do not make provision for the integration of human considerations, while traditional human factors methods do not scale well to the complexity of large-scale nuclear power plant projects. Although the need for up-to-date human factors engineering processes and tools is recognised widely in industry, so far no formal guidance has been developed. This article proposes such a framework.

  5. High-throughput sequencing identifies STAT3 as the DNA-associated factor for p53 - NF-kappaB - complex-dependent gene expression in human heart failure

    E-Print Network [OSTI]

    Choy, Mun-Kit; Movassagh, Mehregan; Siggens, Lee; Vujic, Ana; Goddard, Martin; Sanchez, Ana; Perkins, Neil; Figg, Nichola; Bennett, Martin; Carroll, Jason; Foo, Roger S.-Y.

    2010-06-14

    with this cis-element. Using high-throughput sequencing, we analyzed genome-wide binding sites for the p53-RELA complex in diseased and control human hearts and found a significant overrepresentation of the STAT3 motif. We further determined that STAT3...

  6. Computer Science and Decision Theory Fred S. Roberts 1

    E-Print Network [OSTI]

    Computer Science and Decision Theory Fred S. Roberts 1 DIMACS Center, Rutgers University in the social and decision sciences of newer decision-theoretic methods developed with computer science applications in mind. The paper deals with the relation between computer science and decision-theoretic methods

  7. Summary of Decisions- July 30 – August 3, 2012

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)

  8. RSC DECISION THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL AO DECISION

    E-Print Network [OSTI]

    McLaughlin, Richard M.

    RSC DECISION THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL AO DECISION Application for Residence North Carolina law, bona fide legal residents (domiciliaries) of North Carolina are eligible for a lower are available for inspection in admissions offices. North Carolina statute (G.S. 116-143) requires: "To qualify

  9. Symposium on Human Performance Modeling Wayne D. Gray (Organizer)

    E-Print Network [OSTI]

    Gray, Wayne

    -TG) of the Human Factors & Ergonomics Society. Three Research Talks and a Panel Discussion were presented. Each The Human Performance Modeling Technical Group (HPM-TG) of the Human Factors and Ergonomics Society (HFES by Pew (2007, 2008). Technical Talks An Accessible Cognitive Modeling Tool for Evaluation of Pilot

  10. BASICS OF DESIGN AND CONSTRUCTION OF A HUMAN POWERED SUBMARINE 'CharlesR. Lockert

    E-Print Network [OSTI]

    Wood, Stephen L.

    BASICS OF DESIGN AND CONSTRUCTION OF A HUMAN POWERED SUBMARINE 'CharlesR. Lockert Florid used by the author on the design and construction of the human powered submarine "Sea Panther Panther1!and the rational for those decisions. INTRODUCTION The design and construction of a human powered

  11. Climate Information Needs for Financial Decision Making

    SciTech Connect (OSTI)

    Higgins, Paul

    2013-11-19

    Climate Information Needs for Financial Decision Making (Final Report) This Department of Energy workshop award (grant #DE-SC0008480) provided primary support for the American Meteorological Society’s study on climate information needs for financial decision making. The goal of this study was to help advance societal decision making by examining the implications of climate variability and change on near-term financial investments. We explored four key topics: 1) the conditions and criteria that influence returns on investment of major financial decisions, 2) the climate sensitivity of financial decisions, 3) climate information needs of financial decision makers, and 4) potential new mechanisms to promote collaboration between scientists and financial decision makers. Better understanding of these four topics will help scientists provide the most useful information and enable financial decision makers to use scientific information most effectively. As a result, this study will enable leaders in business and government to make well-informed choices that help maximize long-term economic success and social wellbeing in the United States The outcomes of the study include a workshop, which brought together leaders from the scientific and financial decision making communities, a publication of the study report, and a public briefing of the results to the policy community. In addition, we will present the results to the scientific community at the AMS Annual Meeting in February, 2014. The study results were covered well by the media including Bloomberg News and E&E News. Upon request, we also briefed the Office of Science Technology Policy (OSTP) and the Council on Environmental Quality (CEQ) on the outcomes. We presented the results to the policy community through a public briefing in December on Capitol Hill. The full report is publicly available at www.ametsoc.org/cin. Summary of Key Findings The United States invests roughly $1.5 trillion U.S. dollars (USD) in capital assets each year across the public and private sectors (Orszag 2008; United States Census Bureau 2013). Extreme weather events create and exacerbate risks to these financial investments by contributing to: • Direct physical impacts on the investments themselves • Degradation of critical supporting infrastructure • Changes in the availability of key natural resources • Changes to workforce availability or capacity • Changes in the customer base • Supply chain disruptions • Legal liability • Shifts in the regulatory environment • Reductions in credit ratings Even small changes in weather can impact operations in critical economic sectors. As a result, maximizing returns on financial investments depends on accurately understanding and effectively accounting for these risks. Climate variability and change can either exacerbate existing risks or cause new sources of risk to emerge. Managing these risks most effectively will depend on scientific advances and increases in the capacity of financial decision makers to use the scientific knowledge that results. Barriers to using climate information must also be overcome. This study proposes three predefined levels of certainty for communicating about weather and climate risks: 1) possible (i.e., unknown likelihood or less than 50% chance of occurrence), 2) probable (greater than 50% chance of occurrence), and 3) effectively certain (at least 95% chance of occurrence). For example, it is effectively certain that a change in climate will alter weather patterns. It is probable that climate warming will cause increases in the intensity of some extreme events. It is possible that climate change will cause major and widespread disruptions to key planetary life-support services. Key recommendations of this study: 1) Identify climate-related risks and opportunities for financial decision making. 2) Create a framework to translate scientific information in clear and actionable terms for financial decision makers. 3) Analyze existing climate assessments and translate projected impacts into possible, probable,

  12. 746 eCAADe 24 -session 17: virtual environments 3D City Model Visualization in Decision Theater

    E-Print Network [OSTI]

    decisions while evaluating architectural designs and simulations. The following are indispensable in order in the US3 . However, more than 30% of downtown area is vacant land or used just for parking lots. In order. These VR environments include 3D city models for architectural and urban planning and human organic models

  13. Synthetic Humans in Emergency Response Drills Daniel Massaguer, Vidhya Balasubramanian, Sharad Mehrotra, and Nalini Venkatasubramanian

    E-Print Network [OSTI]

    Venkatasubramanian, Nalini

    Synthetic Humans in Emergency Response Drills Daniel Massaguer, Vidhya Balasubramanian, Sharad demonstrates a concrete model for evacuations integrated with an emergency drill simulation environment this information to make decisions. The decision-making model is tested and calibrated with an emergency drill

  14. Home-based work, human capital accumulation and women's labor force participation 

    E-Print Network [OSTI]

    Chutubtim, Piyaluk

    2006-10-30

    This dissertation examines the effect of changes in the stock of human capital on the labor force participation decision of women aged 25-54. Without the option of homebased work, some women choose to leave the labor market ...

  15. The social influence factor: Impact of online product review characteristics

    E-Print Network [OSTI]

    Al Hanbali, Ahmad

    The social influence factor: Impact of online product review characteristics on consumer purchasing of reviews and consumer purchasing decisions. The impact of online consumer reviews on consumer purchasing. The research challenge therefore entails review function characteristics and its impact on consumer purchasing

  16. Decision Models for Bulk Energy Transportation

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    Decision Models for Bulk Energy Transportation Networks James D. McCalley August 23, 2005 #12, and Electric Transportation Systems (1) What energy flow patterns would yield significantly improved energy (ISU - Randy Larabee) · City of Ames (Ames - Merlin Hove) · MidAmerican Energy (Des Moines - Alan O

  17. Decision-making in autism spectrum conditions

    E-Print Network [OSTI]

    Luke, Lydia R.

    2011-02-08

    at the critical point [and] she was not capable of making a decision’ (Re MB, p427). Similarly, cognitively able patients with anorexia nervosa may lack the capacity to consent to feeding treatment due to their intense fear of weight gain and...

  18. Consciousness, Decision-Making and Neural Computation

    E-Print Network [OSTI]

    Rolls, Edmund T.

    , and an implicit, unconscious route for well-learned actions to obtain goals. Then a higher order syntactic thought the planning, HOST system and not feel like something. Neurally plausible models of decision-Action Cycle: Models, Architectures, and Hardware, Springer Series in Cognitive and Neural Systems 1, DOI 10

  19. The cognitive dynamics underlying decision-making

    E-Print Network [OSTI]

    Jeong, Jaeseung

    )Temporal dynamics 2)Sequential dynamics #12;How does the brain make effective real-world decisions dependent A B C D 0 25 50 75 100 Choicepercentage(%) Options A B C D 0 25 50 75 100 Choicepercentage(%) Options A B C D 0 25 50 75 100 Choicepercentage(%) Options B-Index 0

  20. ATTACHMENT 1 Export Control Decision Tree 1

    E-Print Network [OSTI]

    Jiang, Jiancheng

    ATTACHMENT 1 Export Control Decision Tree 1 for Travel or Shipping to Foreign Countries or Sharing Information with Foreign Nationals United States export controls exist to protect the national security and foreign policy interests of this country. Export controls govern the shipment, transmission, or transfer

  1. Decision Models for Bulk Energy Transportation Networks

    E-Print Network [OSTI]

    Tesfatsion, Leigh

    natural gas pipeline capacity from gulf to NE? Production: How would major investment in a specific/trading restrictions? What would be impacts on fuel and electricity markets? How do high natural gas prices drive1 Decision Models for Bulk Energy Transportation Networks Electrical Engineering Professor Jim Mc

  2. Combinatorische Algoritmen: Binary Decision Diagrams, Deel III

    E-Print Network [OSTI]

    Kosters, Walter

    Decision Diagram (BDD) en hebben we Algoritme C gezien die ons snel het aantal oplossingen van f(x) = 1 door Algoritme B dat oplossingen met een maximaal gewicht kan genereren. In dit deel zullen we uitwerkingen bekijken van Algoritme B (Hoofdstuk 2) en passen we daarna Algoritme C aan om de genererende

  3. University Dining Decisions: Do College Students Make Rational Decisions in the Market for Meal Plans 

    E-Print Network [OSTI]

    Struble, Matthew

    2013-02-04

    When students come to college they take on many responsibilities their parents used to cover for them, including making significant purchase decisions. My research examines the dining plan purchases of students at Texas A&M over time to determine...

  4. Decision Making Under Conditions of Uncertainty: Experimental Assessment of Decision Models 

    E-Print Network [OSTI]

    Vedlitz, Arnold; Mintz, Alex; Redd, Steven B.; Liu, Xinsheng; Alston, Letitia T.

    2005-01-01

    for Science, Technology and Public Policy, George Bush School of Government and Public Service Texas A&M University INTRODUCTION Senior Department of Defense leaders make numerous decisions about the appropriate utilization of complex scientific...-0084 Institute for Science, Technology and Public Policy, George Bush School of Government and Public Service Texas A&M University The poliheuristic theory thus embodies fundamental elements of two disciplines concerned with decision making...

  5. Identifying teacher expertise: An examination of researchers' decision-making 

    E-Print Network [OSTI]

    Stough, Laura

    2005-01-01

    This dissertation is focused on investigating the integration of inventory and facility location decisions in different supply chain settings. Facility location and inventory decisions are interdependent due to the economies ...

  6. Computer-aided decision making for Medical Device Reporting 

    E-Print Network [OSTI]

    Chen, Jih-Horn

    1987-01-01

    , and answer the questions'- "What to do, How, and When?" MDRSOFT, a computer-aided decision making aid for medical de ricr reporting, attempts to capture dynamic problem- solving knowledge through modeling man processed decision making in the domain...

  7. Information Environment and the Investment Decisions of Multinational Corporations

    E-Print Network [OSTI]

    Shroff, Nemit

    This paper examines how the external information environment in which foreign subsidiaries operate affects the investment decisions of multinational corporations (MNCs). We hypothesize and find that the investment decisions ...

  8. Essays on household decision making in developing countries

    E-Print Network [OSTI]

    Berry, James W. (James Wesley)

    2009-01-01

    This dissertation contains three essays on household decision making in the areas of education and health in developing countries. The first chapter explores intra-household decision making in the context of conditional ...

  9. Optimization-based decision support system for retail souring

    E-Print Network [OSTI]

    Patel, Jalpa (Jalpa N.)

    2012-01-01

    Some of the biggest challenges in the retail sourcing lie in predicting demand for a new article and making purchase decisions such as quantity, source, transportation mode and time of the order. Such decisions become more ...

  10. A decision making framework for cruise ship design

    E-Print Network [OSTI]

    Katsoufis, George P. (George Paraskevas)

    2006-01-01

    This thesis develops a new decision making framework for initial cruise ship design. Through review of effectiveness analysis and multi-criteria decision making, a uniform philosophy is created to articulate a framework ...

  11. How the Koontz Decision May Affect Climate Change Policy

    Office of Energy Efficiency and Renewable Energy (EERE)

    Please join us for a Sept. 10 webinar to discuss the Supreme Court's controversial decision in Koontz v. St. Johns River Water Management District and explore how the decision may affect the...

  12. Informing design decisions : an approach to corporate building design

    E-Print Network [OSTI]

    Maxwell, Marc A

    1985-01-01

    This thesis is an investigation into design methodologies. How do we, as designers, prepare ourselves for decision making and evaluate our assumptions and decisions? The intent is to employ this information as a basis for ...

  13. Including model uncertainty in risk-informed decision-making

    E-Print Network [OSTI]

    Reinert, Joshua M

    2005-01-01

    Model uncertainties can have a significant impact on decisions regarding licensing basis changes. We present a methodology to identify basic events in the risk assessment that have the potential to change the decision and ...

  14. Essays on modeling and measurement of consumers' decision strategies

    E-Print Network [OSTI]

    Dzyabura, Daria

    2012-01-01

    This thesis consists of three related essays which explore new approaches to modeling and measurement of consumer decision strategies. The focus is on decision strategies that deviate from von Neumann-Morgenstern utility ...

  15. Decisionmetrices : dynamic structural estimation of shipping investment decisions

    E-Print Network [OSTI]

    Dikos, George

    2004-01-01

    This dissertation develops structural models for analyzing shipping investment decisions, namely ordering, scrapping and lay-up decisions in the tanker industry. We develop models, based on a microeconomic specification, ...

  16. Towards Better Approaches To Decision Support in Logistics Problems

    E-Print Network [OSTI]

    Davidson, Ian

    Towards Better Approaches To Decision Support in Logistics Problems Ian Davidson and Ryszard a decision support framework for logistics problems. The research covers methodologies, technologies and software tools. The framework considers typical characteristics of real-world logistics problems, common

  17. Towards Better Approaches To Decision Support in Logistics Problems

    E-Print Network [OSTI]

    Davidson, Ian

    Towards Better Approaches To Decision Support in Logistics Problems Ian Davidson and Ryszard a decision support framework for logistics problems. The research covers methodologies, technologies and software tools. The framework considers typical characteristics of real­world logistics problems, common

  18. Sampling in human cognition

    E-Print Network [OSTI]

    Vul, Edward

    2010-01-01

    Bayesian Decision Theory describes optimal methods for combining sparse, noisy data with prior knowledge to build models of an uncertain world and to use those models to plan actions and make novel decisions. Bayesian ...

  19. Computation of Texture and Stereoscopic Depth in Humans

    E-Print Network [OSTI]

    Fahle, Manfred

    1989-10-01

    The computation of texture and of stereoscopic depth is limited by a number of factors in the design of the optical front-end and subsequent processing stages in humans and machines. A number of limiting factors in ...

  20. Districts' Integration Efforts in a Changing Climate Two Years After the PICS Decision

    E-Print Network [OSTI]

    Coffie, Abbie; Frankenberg, Erica

    2009-01-01

    Two Years after the PICS Decision: Districts’ Integrationreferred to here as the PICS decision) came into conflictassigning students. The PICS decision does allow a variety

  1. Administrator's Record of Decision (ROD) on New Large Single...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NEW LARGE SINGLE LOAD POLICY ISSUE REVIEW ADMINISTRATOR'S RECORD OF DECISION MARCH 2002 TABLE OF CONTENTS I. Introduction ......

  2. The Transcription Factor Encyclopedia

    E-Print Network [OSTI]

    2012-01-01

    Transcription Factor Encyclopedia. Genome Biology 2012 13:Factor Encyclopedia. Gen- ome Biology 2012, 13:000. where ‘Biology 2012, 13:R24 http://genomebiology.com/2012/13/3/R24 SOFTWARE Open Access The Transcription Factor Encyclopedia

  3. Achieving a Fieldable, Acquisition Process for Human-

    E-Print Network [OSTI]

    Cummings, Mary "Missy"

    Centered Design Environment or Complex Systems. Czaja, Sara J., 1997. "Systems Design and Evaluation," in Handbook of Human Factors and Ergonomics, 2nd Edition. John Wiley and Sons, Inc. Deal, S. (moderator

  4. Use of decision analysis to design a habitat restoration experiment

    E-Print Network [OSTI]

    Use of decision analysis to design a habitat restoration experiment by Ian James Parnell B Project: Use of decision analysis to design a habitat restoration experiment Supervisory Committee costs associated with uncertain outcomes. I used decision analysis to design an example experiment

  5. Stochastic methods for improving secondary production decisions under compositional uncertainty

    E-Print Network [OSTI]

    de Weck, Olivier L.

    the usage of secondary or recycled materials. This thesis aims to improve materials decision making in two of these key areas: 1) blending decisions in manufacturing, and 2) alloy design decisions in product development. The usage of recycled aluminum in alloy blends is greatly hindered by variation in the raw

  6. Procuring Solar Energy: A Guide for Federal Facility Decision Makers

    E-Print Network [OSTI]

    Procuring Solar Energy: A Guide for Federal Facility Decision Makers SEPTEMBER 2010 Solar Energy: www.ntis.gov/help/ordermethods.aspx PROCURING SOLAR ENERGY: A GUIDE FOR FEDERAL FACILITY DECISION MAKERS #12;September 2010 3 Procuring Solar Energy: A Guide for Federal Facility Decision Makers Blaise

  7. ENHANCING DISCRETE CHOICE DEMAND MODELING FOR DECISION-BASED DESIGN

    E-Print Network [OSTI]

    Chen, Wei

    the Decision-Based Design framework. Even though demand modeling techniques exist in market research, little design, in particular that facilitates engineering decision-making. In market research, two major demand1 ENHANCING DISCRETE CHOICE DEMAND MODELING FOR DECISION-BASED DESIGN In Press of ASME Journal

  8. Decision Analysis Vol. 6, No. 2, June 2009, pp. 5356

    E-Print Network [OSTI]

    Chen, Zhongping

    conducted laboratory experiments to examine decision behavior in financial investment decisions, bidding second article is "A Direct Test of Risk Aversion and Regret in First Price Sealed-Bid Auctions to investment firms to chem- ical companies to government. Decision Analysis is 1 For the Editorial Board

  9. Decision Analysis of Dynamic Spectrum Access Rules

    SciTech Connect (OSTI)

    Juan D. Deaton; Luiz A. DaSilva; Christian Wernz

    2011-12-01

    A current trend in spectrum regulation is to incorporate spectrum sharing through the design of spectrum access rules that support Dynamic Spectrum Access (DSA). This paper develops a decision-theoretic framework for regulators to assess the impacts of different decision rules on both primary and secondary operators. We analyze access rules based on sensing and exclusion areas, which in practice can be enforced through geolocation databases. Our results show that receiver-only sensing provides insufficient protection for primary and co-existing secondary users and overall low social welfare. On the other hand, using sensing information between the transmitter and receiver of a communication link, provides dramatic increases in system performance. The performance of using these link end points is relatively close to that of using many cooperative sensing nodes associated to the same access point and large link exclusion areas. These results are useful to regulators and network developers in understanding in developing rules for future DSA regulation.

  10. Sequential valuation networks for asymmetric decision problems

    E-Print Network [OSTI]

    Demirer, Riza; Shenoy, Prakash P.

    2006-02-16

    .040 R b, 0.100 e, 0.600 A as, 0.400 al, 0.460 am, 0.140 .120 .138 .042 .540 .036 .024 A al, 0.700 am, 0.300 .070 .030 Demirer and Shenoy 6 Figure 3. A Decision Tre Representation and Solution of the Reactor Problem. R Profit, B$ D 1 A D 2 C 8 ?4...

  11. Dynamic diagnostic and decision procedures under uncertainty

    SciTech Connect (OSTI)

    Baranov, V.V.

    1995-01-01

    In this paper, we consider uncertainty that arises when the true state x {element_of} E is not accessible to direct observation and remains unknown. Instead, we observe some features {theta} {element_of} {Theta} that carry a certain information about the true state. This information is described by the conditional distribution P({Theta}{vert_bar}E), which we call the linkage distribution. Regarding this distribution we assume that it exists but is unknown. This leads to uncertainty with respect to states from E and the linkage distribution P({Theta}{vert_bar}E), which we denote by NEP. The substantive problem can be stated as follows: from observations of the features {theta}{element_of}{Theta} made at each time instant n = 1,2,...,recognize the state x {element_of} E, identify the linkage distribution P, and use the results of recognition and identification to choose a decision y {element_of} Y so that the decision process is optimal in some sense. State recognition is the subject of diagnostics. The uncertainty NEP thus generates a problem of diagnostics and dynamic decision making.

  12. Naturalistic Decision Making For Power System Operators

    SciTech Connect (OSTI)

    Greitzer, Frank L.; Podmore, Robin; Robinson, Marck; Ey, Pamela

    2009-06-23

    Abstract: Motivation -- As indicated by the Blackout of 2003, the North American interconnected electric system is vulnerable to cascading outages and widespread blackouts. Investigations of large scale outages often attribute the causes to the three T’s: Trees, Training and Tools. A systematic approach has been developed to document and understand the mental processes that an expert power system operator uses when making critical decisions. The approach has been developed and refined as part of a capability demonstration of a high-fidelity real-time power system simulator under normal and emergency conditions. To examine naturalistic decision making (NDM) processes, transcripts of operator-to-operator conversations are analyzed to reveal and assess NDM-based performance criteria. Findings/Design -- The results of the study indicate that we can map the Situation Awareness Level of the operators at each point in the scenario. We can also identify clearly what mental models and mental simulations are being performed at different points in the scenario. As a result of this research we expect that we can identify improved training methods and improved analytical and visualization tools for power system operators. Originality/Value -- The research applies for the first time, the concepts of Recognition Primed Decision Making, Situation Awareness Levels and Cognitive Task Analysis to training of electric power system operators. Take away message -- The NDM approach provides an ideal framework for systematic training management and mitigation to accelerate learning in team-based training scenarios with high-fidelity power grid simulators.

  13. Factors influencing landowner willingness to enroll in a cost-share brush management program in the Pedernales River watershed, Texas 

    E-Print Network [OSTI]

    Tays, Mark Robert

    2001-01-01

    was mailed to 720 randomly selected landowners in Blanco and Gillespie Counties to identify factors they found important in their decisions concerning brush management and their willingness to participate in cost-share brush management programs. A total...

  14. Factors Affecting Strategic Choices of the European Union Maritime Shipping Industry: Pre and Post European Union Anti-Trust Exemption 

    E-Print Network [OSTI]

    Henderson, Samuel R.

    2010-07-14

    This research is to explore the factors that affect the strategic decision to use or not use pools and conferences within the European Union (“EU”) maritime industry. The following research questions will be explored: What were the differences pre...

  15. Use of wind power forecasting in operational decisions.

    SciTech Connect (OSTI)

    Botterud, A.; Zhi, Z.; Wang, J.; Bessa, R.J.; Keko, H.; Mendes, J.; Sumaili, J.; Miranda, V.

    2011-11-29

    The rapid expansion of wind power gives rise to a number of challenges for power system operators and electricity market participants. The key operational challenge is to efficiently handle the uncertainty and variability of wind power when balancing supply and demand in ths system. In this report, we analyze how wind power forecasting can serve as an efficient tool toward this end. We discuss the current status of wind power forecasting in U.S. electricity markets and develop several methodologies and modeling tools for the use of wind power forecasting in operational decisions, from the perspectives of the system operator as well as the wind power producer. In particular, we focus on the use of probabilistic forecasts in operational decisions. Driven by increasing prices for fossil fuels and concerns about greenhouse gas (GHG) emissions, wind power, as a renewable and clean source of energy, is rapidly being introduced into the existing electricity supply portfolio in many parts of the world. The U.S. Department of Energy (DOE) has analyzed a scenario in which wind power meets 20% of the U.S. electricity demand by 2030, which means that the U.S. wind power capacity would have to reach more than 300 gigawatts (GW). The European Union is pursuing a target of 20/20/20, which aims to reduce greenhouse gas (GHG) emissions by 20%, increase the amount of renewable energy to 20% of the energy supply, and improve energy efficiency by 20% by 2020 as compared to 1990. Meanwhile, China is the leading country in terms of installed wind capacity, and had 45 GW of installed wind power capacity out of about 200 GW on a global level at the end of 2010. The rapid increase in the penetration of wind power into power systems introduces more variability and uncertainty in the electricity generation portfolio, and these factors are the key challenges when it comes to integrating wind power into the electric power grid. Wind power forecasting (WPF) is an important tool to help efficiently address this challenge, and significant efforts have been invested in developing more accurate wind power forecasts. In this report, we document our work on the use of wind power forecasting in operational decisions.

  16. The Human Genome Diversity Project

    SciTech Connect (OSTI)

    Cavalli-Sforza, L.

    1994-12-31

    The Human Genome Diversity Project (HGD Project) is an international anthropology project that seeks to study the genetic richness of the entire human species. This kind of genetic information can add a unique thread to the tapestry knowledge of humanity. Culture, environment, history, and other factors are often more important, but humanity`s genetic heritage, when analyzed with recent technology, brings another type of evidence for understanding species` past and present. The Project will deepen the understanding of this genetic richness and show both humanity`s diversity and its deep and underlying unity. The HGD Project is still largely in its planning stages, seeking the best ways to reach its goals. The continuing discussions of the Project, throughout the world, should improve the plans for the Project and their implementation. The Project is as global as humanity itself; its implementation will require the kinds of partnerships among different nations and cultures that make the involvement of UNESCO and other international organizations particularly appropriate. The author will briefly discuss the Project`s history, describe the Project, set out the core principles of the Project, and demonstrate how the Project will help combat the scourge of racism.

  17. Evolution-Centered Architectural Design Decisions Management Meiru Che, Dewayne E. Perry

    E-Print Network [OSTI]

    Perry, Dewayne E.

    Evolution-Centered Architectural Design Decisions Management Meiru Che, Dewayne E. Perry Department decisions. Managing the evolution of architectural design decisions helps to maintain consistency between. The UML metamodel incorporates evolution-centered characteristics to manage architectural design decision

  18. Decision analysis for INEL hazardous waste storage

    SciTech Connect (OSTI)

    Page, L.A.; Roach, J.A.

    1994-01-01

    In mid-November 1993, the Idaho National Engineering Laboratory (INEL) Waste Reduction Operations Complex (WROC) Manager requested that the INEL Hazardous Waste Type Manager perform a decision analysis to determine whether or not a new Hazardous Waste Storage Facility (HWSF) was needed to store INEL hazardous waste (HW). In response to this request, a team was formed to perform a decision analysis for recommending the best configuration for storage of INEL HW. Personnel who participated in the decision analysis are listed in Appendix B. The results of the analysis indicate that the existing HWSF is not the best configuration for storage of INEL HW. The analysis detailed in Appendix C concludes that the best HW storage configuration would be to modify and use a portion of the Waste Experimental Reduction Facility (WERF) Waste Storage Building (WWSB), PBF-623 (Alternative 3). This facility was constructed in 1991 to serve as a waste staging facility for WERF incineration. The modifications include an extension of the current Room 105 across the south end of the WWSB and installing heating, ventilation, and bay curbing, which would provide approximately 1,600 ft{sup 2} of isolated HW storage area. Negotiations with the State to discuss aisle space requirements along with modifications to WWSB operating procedures are also necessary. The process to begin utilizing the WWSB for HW storage includes planned closure of the HWSF, modification to the WWSB, and relocation of the HW inventory. The cost to modify the WWSB can be funded by a reallocation of funding currently identified to correct HWSF deficiencies.

  19. INTRODUCTION Recent research on human-automation inter-

    E-Print Network [OSTI]

    Kaber, David B.

    INTRODUCTION Recent research on human-automation inter- action theory (Endsley & Kaber, 1999 decisions about what complex system functions to automate, and to what extent, in advance of implementation and as part of the systems de- sign process. This work has relevance to adap- tive automation. Adaptive

  20. Better Buildings Alliance Solar Decision Guide

    Office of Energy Efficiency and Renewable Energy (EERE)

    Businesses considering implementing solar PV may encounter widespread geographic differences regarding utility incentive structures (buy-down incentives, performance based incentives, feed-in tariffs, etc.), utility policies (net metering, interconnection requirements), regulatory structures, and permitting requirements. They might also have uncertainty about how to assess the different ownership structures (PPA, lease, own, etc.). The Solar Decision Guide can help companies navigate this complex environment to determine if investing in solar makes financial sense and to identify the regions that offer the most promising returns on solar investment.

  1. Cognitive decision errors and organization vulnerabilities in nuclear power plant safety management: Modeling using the TOGA meta-theory framework

    SciTech Connect (OSTI)

    Cappelli, M.; Gadomski, A. M.; Sepiellis, M.; Wronikowska, M. W.

    2012-07-01

    In the field of nuclear power plant (NPP) safety modeling, the perception of the role of socio-cognitive engineering (SCE) is continuously increasing. Today, the focus is especially on the identification of human and organization decisional errors caused by operators and managers under high-risk conditions, as evident by analyzing reports on nuclear incidents occurred in the past. At present, the engineering and social safety requirements need to enlarge their domain of interest in such a way to include all possible losses generating events that could be the consequences of an abnormal state of a NPP. Socio-cognitive modeling of Integrated Nuclear Safety Management (INSM) using the TOGA meta-theory has been discussed during the ICCAP 2011 Conference. In this paper, more detailed aspects of the cognitive decision-making and its possible human errors and organizational vulnerability are presented. The formal TOGA-based network model for cognitive decision-making enables to indicate and analyze nodes and arcs in which plant operators and managers errors may appear. The TOGA's multi-level IPK (Information, Preferences, Knowledge) model of abstract intelligent agents (AIAs) is applied. In the NPP context, super-safety approach is also discussed, by taking under consideration unexpected events and managing them from a systemic perspective. As the nature of human errors depends on the specific properties of the decision-maker and the decisional context of operation, a classification of decision-making using IPK is suggested. Several types of initial situations of decision-making useful for the diagnosis of NPP operators and managers errors are considered. The developed models can be used as a basis for applications to NPP educational or engineering simulators to be used for training the NPP executive staff. (authors)

  2. Visualizing subjective decision criteria for system evaluation

    E-Print Network [OSTI]

    Coley, Jodyann Felicia

    2010-01-01

    The tools and methods used to evaluate complex systems in terms of human systems integration (HSI) include software, hardware, models, simulations, processes, and techniques. Hundreds of such tools currently exist to ...

  3. Factored Models for Multiscale Decision-Making in Smart Grid Customers Prashant P. Reddy

    E-Print Network [OSTI]

    Veloso, Manuela M.

    of customers in the management of demand, and renewable energy supply, is a critical goal of the Smart Grid as consumers, producers and storage facilities or more explicitly as suburban homes, office complexes, solar at the granularity of a single household with each appliance modeled separately, at the aggregate behavior

  4. Taxonomy learning factoring the structure of a taxonomy into a semantic classification decision

    E-Print Network [OSTI]

    of a thesaurus to improve the accuracy of classifying new words into its classes. The results of the study demon a thesaurus with new lexical items. The specifics of the task are a big number of classes into which new words advantage of information about taxo- nomic relations between word classes contained in a thesaurus

  5. Recruitment Experiences and Decision Factors of High School Science Teachers in Texas 

    E-Print Network [OSTI]

    Richardson, Rasheedah 1978-

    2012-08-02

    school science teachers at the entry stage of the teacher professional continuum (TPC): recruitment. Little is understood about the relationship between recruitment, job satisfaction and retention of teachers. A conceptual framework (i.e., teacher-to-school...

  6. Assessment of wind power predictability as a decision factor in the investment phase of wind farms

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    the point of view of a producer participating in the day-ahead electricity market, lack of predictability price settlement mechanism will remain the same. Keywords: Wind power resource assessment, Wind power GW by 2020 according to EWEA projections (see [1]). Such large-scale integration of wind energy

  7. Efficient Regression of General-Activity Human Poses from Depth Images Ross Girshick

    E-Print Network [OSTI]

    Kohli, Pushmeet

    Efficient Regression of General-Activity Human Poses from Depth Images Ross Girshick Jamie Shotton of several decision-tree training ob- jectives. Key aspects of our work include: regression di- rectly from the regression-based ap- proaches that have been a staple of monocular 2D human pose estimation [1, 19, 10, 15

  8. About the Psychology Major Psychology is the study of human and animal behavior,

    E-Print Network [OSTI]

    Kachroo, Pushkin

    About the Psychology Major Psychology is the study of human and animal behavior, including human emotions, thoughts, and motives. The B.A. degree in Psychology at UNLV provides essential experiences and collecting evidence on which to base important decisions. Job opportunities for psychology majors include

  9. Office of Legacy Management Decision Tree for Solar Photovoltaic Projects - 13317

    SciTech Connect (OSTI)

    Elmer, John; Butherus, Michael; Barr, Deborah L.

    2013-07-01

    To support consideration of renewable energy power development as a land reuse option, the DOE Office of Legacy Management (LM) and the National Renewable Energy Laboratory (NREL) established a partnership to conduct an assessment of wind and solar renewable energy resources on LM lands. From a solar capacity perspective, the larger sites in the western United States present opportunities for constructing solar photovoltaic (PV) projects. A detailed analysis and preliminary plan was developed for three large sites in New Mexico, assessing the costs, the conceptual layout of a PV system, and the electric utility interconnection process. As a result of the study, a 1,214-hectare (3,000-acre) site near Grants, New Mexico, was chosen for further study. The state incentives, utility connection process, and transmission line capacity were key factors in assessing the feasibility of the project. LM's Durango, Colorado, Disposal Site was also chosen for consideration because the uranium mill tailings disposal cell is on a hillside facing south, transmission lines cross the property, and the community was very supportive of the project. LM worked with the regulators to demonstrate that the disposal cell's long-term performance would not be impacted by the installation of a PV solar system. A number of LM-unique issues were resolved in making the site available for a private party to lease a portion of the site for a solar PV project. A lease was awarded in September 2012. Using a solar decision tree that was developed and launched by the EPA and NREL, LM has modified and expanded the decision tree structure to address the unique aspects and challenges faced by LM on its multiple sites. The LM solar decision tree covers factors such as land ownership, usable acreage, financial viability of the project, stakeholder involvement, and transmission line capacity. As additional sites are transferred to LM in the future, the decision tree will assist in determining whether a solar PV project is feasible on the new sites. (authors)

  10. INTERIM REPORT IMPROVED METHODS FOR INCORPORATING RISK IN DECISION MAKING

    SciTech Connect (OSTI)

    Clausen, M. J.; Fraley, D. W.; Denning, R. S.

    1980-08-01

    This paper reports observations and preliminary investigations in the first phase of a research program covering methodologies for making safety-related decisions. The objective has been to gain insight into NRC perceptions of the value of formal decision methods, their possible applications, and how risk is, or may be, incorporated in decision making. The perception of formal decision making techniques, held by various decision makers, and what may be done to improve them, were explored through interviews with NRC staff. An initial survey of decision making methods, an assessment of the applicability of formal methods vis-a-vis the available information, and a review of methods of incorporating risk and uncertainty have also been conducted.

  11. Technical report on LWR design decision methodology. Phase I

    SciTech Connect (OSTI)

    None

    1980-03-01

    Energy Incorporated (EI) was selected by Sandia Laboratories to develop and test on LWR design decision methodology. Contract Number 42-4229 provided funding for Phase I of this work. This technical report on LWR design decision methodology documents the activities performed under that contract. Phase I was a short-term effort to thoroughly review the curret LWR design decision process to assure complete understanding of current practices and to establish a well defined interface for development of initial quantitative design guidelines.

  12. D2 Dopamine Receptor Mediation of Risky Decision-making 

    E-Print Network [OSTI]

    Simon, Nicholas Wayne

    2011-08-08

    of D2 cRNA hybridization in both orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC) predicted risky decision-making behavior as assessed by nonlinear curve estimation analyses. Interestingly, opposite relationships between D2 m...-making ............................................................................. 85 Prefrontal Cortex Dopaminergic Mediation of Risky Decision-making ......... 85 Striatal Dopaminergic Mediation of Risky Decision-making ......................... 87 The Relationship between D2 Receptors and Other Forms of Cost...

  13. Record of Decision for the Department of Energy's Waste Management...

    Office of Environmental Management (EM)

    the nation's nuclear weapons program. This decision enables the Department to integrate waste management activities among sites to promote expeditious, compliant, and cost...

  14. Engaging Non-IT Executives in IT Infrastructure Decisions

    E-Print Network [OSTI]

    Fonstad, Nils O.

    2008-07-01

    This case study describes how information technology (IT) managers from Insurance Co. successfully engaged non-IT executives in IT infrastructure investment decisions. This

  15. Memorandum of Decision: Withdrawal of Waiver for Fluorescent...

    Energy Savers [EERE]

    & Publications Nationwide Categorical Waiver Memorandum of Decision: Withdrawal of LED Lighting Waiver ISSUANCE 2014-12-29: Energy Conservation Program: Clarification for...

  16. Risk-Averse Dynamic Programming for Markov Decision Processes?

    E-Print Network [OSTI]

    2009-12-20

    ?Presented at the 20th International Symposium on Mathematical Programming, ... discuss relations of our results to min-max Markov decision problems.

  17. EIS-0380: Record of Decision | Department of Energy

    Energy Savers [EERE]

    of Decision: Site-Wide Environmental Impact Statement for Continued Operation of Los Alamos National Laboratory, Los Alamos, New Mexico, DOEEIS-0380 (September 2008) 73 FR 55833...

  18. The Role of GIS in Decision Support Systems

    Office of Environmental Management (EM)

    GIS in Decision Support Systems Jeremy Smith Weather Camera Rail Bridge T k Mile Post Traffic Truck Origin Destination Route Alternatives Roadway Time Pavement Incidents Closures...

  19. EM Risk and Cleanup Decision Making Presentation by Mark Gilbertson...

    Office of Environmental Management (EM)

    * Existing environment and health risk www.em.doe.gov 2 * Existing environment and health risk analysis to support decision-making * Considerations going forward The Past Five...

  20. Decision making under epistemic uncertainty : an application to seismic design

    E-Print Network [OSTI]

    Agarwal, Anna

    2008-01-01

    The problem of accounting for epistemic uncertainty in risk management decisions is conceptually straightforward, but is riddled with practical difficulties. Simple approximations are often used whereby future variations ...

  1. Strategies and Decision Support Systems for Integrating Variable...

    Open Energy Info (EERE)

    the design of decision support tools, solutions and strategies for integrating more wind energy into their own power systems. The findings help to increase the industry-wide...

  2. Microsoft Word - Improved Interfaces and Decision Support_FINAL...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the skill sets and performance of today's system operators. * Customer Decision Making - Demand Response (DR) systems will provide information to customers in easily understood...

  3. EIS-0220: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Decision Interim Management of Nuclear Materials at Savannah River Site (December 1995) DOE has decided to initiate actions which will stabilize certain of the SRS materials...

  4. Software platform for integrated water quality decision support systems

    E-Print Network [OSTI]

    Software platform for integrated water quality decision support systems P. Cianchi*, S. Marsili Processing) modules with limited computing capacity. Defining agents as a self contained software program

  5. Critical Decision 4 (CD-4) Approval Template | Department of...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    More Documents & Publications Example BCP Template Critical Decision 2 (CD-2) Approval Template SOW and Key Performance Parameters (KPP) Handbook Final Version 9-30-2014...

  6. Procuring Solar Energy: A Guide for Federal Facility Decision...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Procuring Solar Energy: A Guide for Federal Facility Decision Makers, Solar Screening Evaluation Checklist, September 2010 Procuring Solar Energy: A Guide for Federal Facility...

  7. Sandia Energy - Decision Support for Integrated Energy-Water...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    versus out of basin production (i.e., tradeoff in energy reliability versus reduced pollution and water use)? The decision support framework will be designed to link a...

  8. Applying Climate Information for Adaptation Decision-Making:...

    Open Energy Info (EERE)

    Applying Climate Information for Adaptation Decision-Making: A Guidance and Resource Document Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Applying Climate...

  9. Decisions regarding how to secure and invest in our

    Office of Environmental Management (EM)

    to ensure that the Nation's energy delivery system is secure, resilient and reliable. Pictures go here. Creating a Risk Assessment Culture for State Energy Infrastructure Decision...

  10. Characterizing Uncertainty for Regional Climate Change Mitigation and Adaptation Decisions

    SciTech Connect (OSTI)

    Unwin, Stephen D.; Moss, Richard H.; Rice, Jennie S.; Scott, Michael J.

    2011-09-30

    This white paper describes the results of new research to develop an uncertainty characterization process to help address the challenges of regional climate change mitigation and adaptation decisions.

  11. Learning environment simulator: a tool for local decision makers and first responders

    SciTech Connect (OSTI)

    Leclaire, Rene J [Los Alamos National Laboratory; Hirsch, Gary B [CLE, INCORPORATED

    2009-01-01

    The National Infrastructure Simulation and Analysis Center (NISAC) has developed a prototype learning environment simulator (LES) based on the Critical Infrastructure Protection Decision Support System (CIPDSS) infrastructure and scenario models. The LES is designed to engage decision makers at the grass-roots level (local/city/state) to deepen their understanding of an evolving crisis, enhance their intuition and allow them to test their own strategies for events before they occur. An initial version is being developed, centered on a pandemic influenza outbreak and has been successfully tested with a group of hospital administrators and first responders. LES is not a predictive tool but rather a simulated environment allowing the user to experience the complexities of a crisis before it happens. Users can contrast various approaches to the crisis, competing with alternative strategies of their own or other participants. LES is designed to assist decision makers in making informed choices by functionally representing relevant scenarios before they occur, including impacts to critical infrastructures with their interdependencies, and estimating human health & safety and economic impacts. In this paper a brief overview of the underlying models are given followed by a description of the LES, its interface and usage and an overview of the experience testing LES with a group of hospital administrators and first responders. The paper concludes with a brief discussion of the work remaining to make LES operational.

  12. Human Subjects Section 6. Protection of Human

    E-Print Network [OSTI]

    Heller, Barbara

    Human Subjects Section 6. Protection of Human Subjects This section is required for applicants answering "yes" to the question "Are human subjects involved?" on the R&R Other Project Information form subjects applicants must provide a justification in this section for the claim that no human subjects

  13. Initial Risk Analysis and Decision Making Framework

    SciTech Connect (OSTI)

    Engel, David W.

    2012-02-01

    Commercialization of new carbon capture simulation initiative (CCSI) technology will include two key elements of risk management, namely, technical risk (will process and plant performance be effective, safe, and reliable) and enterprise risk (can project losses and costs be controlled within the constraints of market demand to maintain profitability and investor confidence). Both of these elements of risk are incorporated into the risk analysis subtask of Task 7. Thus far, this subtask has developed a prototype demonstration tool that quantifies risk based on the expected profitability of expenditures when retrofitting carbon capture technology on a stylized 650 MW pulverized coal electric power generator. The prototype is based on the selection of specific technical and financial factors believed to be important determinants of the expected profitability of carbon capture, subject to uncertainty. The uncertainty surrounding the technical performance and financial variables selected thus far is propagated in a model that calculates the expected profitability of investments in carbon capture and measures risk in terms of variability in expected net returns from these investments. Given the preliminary nature of the results of this prototype, additional work is required to expand the scope of the model to include additional risk factors, additional information on extant and proposed risk factors, the results of a qualitative risk factor elicitation process, and feedback from utilities and other interested parties involved in the carbon capture project. Additional information on proposed distributions of these risk factors will be integrated into a commercial implementation framework for the purpose of a comparative technology investment analysis.

  14. LTC 1073 vacuum blasting (concrete) human factors assessment -- Baseline (summary)

    SciTech Connect (OSTI)

    1997-07-31

    The LTC 1073 Vacuum Blasting Machine uses a high capacity, direct pressure blasting system incorporating a continuous feed for the blast media. The blast media cleans the surface within the contained brush area of the blast head. A vacuum system removes dust and debris from the surfaces as it is blasted. After cleaning the surface, the abrasive, together with the rust or coating that was removed from the surface, is vacuumed into the machine through the suction hose. The dust separator contains angled steel collision pads, working with the force of gravity, to allow any reusable abrasive to fall back into the pressure vessel. The filters are manually back flushed to prevent clogging. After back flushing, dust is dumped from the dust chamber into the dust collection bag or drum by operation of the bellows valve. The safety and health evaluation during the testing demonstration focused on dust and noise exposure. Dust exposure was found to be minimal, but noise exposure was potentially significant. Further testing for each of these exposures is recommended because the outdoor environment where the testing demonstration took place may cause the results to be inapplicable to indoor settings. It is feasible that the dust and noise levels will be higher in an enclosed operating environment. Other safety and health issues found were ergonomics, heat stress, tripping hazards, lockout/tagout, and arm-hand vibration.

  15. Transfer passenger needs at airports : human factors in terminal design

    E-Print Network [OSTI]

    Brillembourg, Marie-Claire

    1982-01-01

    This thesis analyzes the needs of particular users of airport: transfer passengers. The object of this work has been to produce a set of design guidelines for terminals. these guidelines are framed upon a user-need survey ...

  16. ACCIDENT ANALYSIS AND HAZARD ANALYSIS FOR HUMAN AND ORGANIZATIONAL FACTORS

    E-Print Network [OSTI]

    Leveson, Nancy

    culpable. An accident analysis method is needed that will guide the work, aid in the analysis of the role

  17. Incidents at nuclear power plants caused by the human factor

    SciTech Connect (OSTI)

    Mashin, V. A.

    2012-09-15

    Psychological analysis of the causes of incorrect actions by personnel is discussed as presented in the report 'Methodological guidelines for analyzing the causes of incidents in the operation of nuclear power plants.' The types of incorrect actions and classification of the root causes of errors by personnel are analyzed. Recommendations are made for improvements in the psychological analysis of causes of incorrect actions by personnel.

  18. The Security of Russia's Nuclear Arsenal: The Human Factor

    SciTech Connect (OSTI)

    Ball, D.Y.

    1999-10-12

    Assertions by the Russian military that all of their nuclear weapons are secure against theft and that nuclear units within the military are somehow insulated from the problems plaguing the Russian military should not be accepted uncritically. Accordingly, we should not give unwarranted credence to the pronouncements of military figures like Cal.-Gen. Igor Valynkin, Chief of the Defense Ministry's 12th Main Directorate, which oversees the country's nuclear arsenal. He contends that ''Russian nuclear weapons are under reliable supervision'' and that ''talk about the unreliability of our control over nuclear weapons has only one pragmatic goal--to convince international society that the country is incapable of maintaining nuclear safety and to introduce international oversight over those weapons, as it is done, for example, in Iraq.'' While the comparison to Iraq is preposterous, many analysts might agree with Valynkin's sanguine appraisal of the security of Russia's nuclear weapons. In contrast, I argue that the numerous difficulties confronting the military as a whole should cause concern in the West over the security of the Russian nuclear arsenal.

  19. PUTTING THE HUMAN FACTOR INTO SYSTEMS DEVELOPMENT Ben Shneiderman

    E-Print Network [OSTI]

    Shneiderman, Ben

    in interactive systems, but these four related approaches may be useful: - Create like an inspired inventor of this paper. Create like a__n inspired inventor The absence of firm guidelines for interactive systems design

  20. Proceedings of the Twenty-First Water Reactor Safety Information Meeting: Volume 1, Plenary session; Advanced reactor research; advanced control system technology; advanced instrumentation and control hardware; human factors research; probabilistic risk assessment topics; thermal hydraulics; thermal hydraulic research for advanced passive LWRs

    SciTech Connect (OSTI)

    Monteleone, S.

    1994-04-01

    This three-volume report contains 90 papers out of the 102 that were presented at the Twenty-First Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, during the week of October 25--27, 1993. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Germany, Japan, Russia, Switzerland, Taiwan, and United Kingdom. The titles of the papers and the names of the authors have been updated and may differ from those that appeared in the final program of the meeting. Individual papers have been cataloged separately. This document, Volume 1 covers the following topics: Advanced Reactor Research; Advanced Instrumentation and Control Hardware; Advanced Control System Technology; Human Factors Research; Probabilistic Risk Assessment Topics; Thermal Hydraulics; and Thermal Hydraulic Research for Advanced Passive Light Water Reactors.

  1. Enhancing Financial Decision-Making Using Social Behavior Modeling

    E-Print Network [OSTI]

    movements. This pro- cess can be modeled by connecting online social behavior and future trading behaviorEnhancing Financial Decision-Making Using Social Behavior Modeling Ruoqian Liu, Ankit Agrawal, Wei is a social activity that involves every par- ticipant's decision making. Meanwhile, people's online be

  2. Piecewise Stationary Markov Decision Processes, I: Constant Gain

    E-Print Network [OSTI]

    Shwartz, Adam

    -making models to which we refer as Piecewise Stationary Markov Decision Processes (PSMDPs). In these models, the decision making horizon can be partitioned into intervals, called renewal cycles, of N + 1 epochs. The transition law and reward function are identical over the #12;rst N epochs of each renewal cycle

  3. A Bayesian Decision Model for Intelligent Routing in Sensor Networks

    E-Print Network [OSTI]

    Marques, Antonio Garcia

    A Bayesian Decision Model for Intelligent Routing in Sensor Networks Roc´io Arroyo-Valles, Antonio are considered in a Bayesian model in order to establish intelligent decision rules that make the network economize in crucial resources. I. INTRODUCTION Recent advances in sensor technology and wireless com

  4. Decision Analysis Vol. 7, No. 2, June 2010, pp. 151154

    E-Print Network [OSTI]

    Chen, Zhongping

    . W. Merrick and Laura A. McLay ask "Is Screening Cargo Containers for Smuggled Nuclear Threats Options Using an Implied Binomial Tree," is by Tianyang Wang and James S. Dyer. The next article; common value; Cox's axioms; decision analysis; decision-focused transformation; elicitation; expert

  5. KNOWLEDGE-BASED DECISION SUPPORT IN OIL WELL DRILLING

    E-Print Network [OSTI]

    Aamodt, Agnar

    KNOWLEDGE-BASED DECISION SUPPORT IN OIL WELL DRILLING Combining general and case-specific knowledge of Computer and Information Science. agnar.aamodt@idi.ntnu.no Abstract: Oil well drilling is a complex process for information handling, decision-making, and on-the-job learning for drilling personnel in their daily working

  6. Discrimination Decisions for 100,000Dimensional William A. Gale

    E-Print Network [OSTI]

    Yarowsky, David

    Discrimination Decisions for 100,000­Dimensional Spaces William A. Gale Kenneth W. Church David Yarowsky AT&T Bell Laboratories e­mail: fgale, kwc, yarowskyg@research.att.com Abstract Discrimination decisions arise in many natural language processing tasks. Three classical tasks are discriminating texts

  7. Stopped Decision Processes in conjunction with General Utility

    E-Print Network [OSTI]

    Yasuda, Masami

    Stopped Decision Processes in conjunction with General Utility Yoshinobu KADOTA Dep. of Math process and the stopping prob­ lem, called Stopped Decision Processes, with a general utility and piecewise deterministic Markov processes, etc. Our aim is to formulate the general utility

  8. Decision Trees: More Theoretical Justification for Practical Algorithms

    E-Print Network [OSTI]

    Fiat, Amos

    Decision Trees: More Theoretical Justification for Practical Algorithms Amos Fiat and Dmitry,pechyony}@tau.ac.il Abstract. We study impurity­based decision tree algorithms such as CART, C4.5, etc., so as to better understand their theoretical under­ pinnings. We consider such algorithms on special forms of functions

  9. Modelling Lexical Decision: Who needs a lexicon? John A. Bullinaria

    E-Print Network [OSTI]

    Bullinaria, John

    Modelling Lexical Decision: Who needs a lexicon? John A. Bullinaria Centre for Speech and Language decision can be performed by a simple neural network with no explicit lexicon and no recurrent connections agreement with various experimental data concerning semantic and associative priming. 1. Introduction

  10. Evolving OWA Operators for Cyber Security Decision Making Problems

    E-Print Network [OSTI]

    Aickelin, Uwe

    Evolving OWA Operators for Cyber Security Decision Making Problems Simon Miller Jonathan M cyber security experts took part in an exercise in which they independently assessed a realistic system--Ordered Weighted Average, Evolutionary Algo- rithms, Simulated Annealing, Cyber Security, Expert Decision Making I

  11. Incorporating Pricing Decisions into the Stochastic Dynamic Fleet Management Problem

    E-Print Network [OSTI]

    Topaloglu, Huseyin

    their expected values. A second class of fleet management models try to treat the randomness in the load arrivalsIncorporating Pricing Decisions into the Stochastic Dynamic Fleet Management Problem Huseyin This paper shows how to coordinate the pricing and fleet management decisions of a freight carrier. We

  12. Efficient Sequential Decision-Making Algorithms for Container Inspection

    E-Print Network [OSTI]

    Madigan, David

    formulate a port of entry inspection sequencing task as a problem of finding an optimal binary decision tree for an appropriate Boolean decision function. We report on new algorithms for finding such optimal trees the method. Finding algorithms for sequential diagnosis that minimize the total "cost" of the inspection

  13. A PROTOTYPE DECISION SUPPORT SYSTEM FOR GMO TRACEABILITY

    E-Print Network [OSTI]

    Novak, Petra Kralj

    A PROTOTYPE DECISION SUPPORT SYSTEM FOR GMO TRACEABILITY Petra Kralj(1), Nada Lavrac(1,2), Kristina. In this paper we present a prototype decision support system for GMO detection and identification. 1 INTRODUCTION A genetically modified organism (GMO) is an organism whose genetic material (Figure 1) has been

  14. Smarter Cropping: Internet program helps farmers make decisions about crops 

    E-Print Network [OSTI]

    Wythe, Kathy

    2009-01-01

    Wythe tx H2O | pg. 26 Smarter Cropping Internet program helps farmers make decisions about crops Along the coastal plains of Texas, farmers and crop managers are using the Internet to make more informed decisions about growing cotton. This Web...

  15. The Relationship of Work Engagement, Work-life Balance, and Occupational Commitment on the Decisions of Agricultural Educators to Remain in the Teaching Profession. 

    E-Print Network [OSTI]

    Crutchfield, Nina R.

    2010-07-14

    , and personal and career factors as related to the decision to remain in the teaching profession. The target population for this study was defined as experienced agricultural educators who had completed a minimum of four years of teaching experience, who were...

  16. Enhancing the systems decision process with flexibility analysis for optimal unmanned aircraft system selection

    E-Print Network [OSTI]

    Bachmann, Chris H., III (Christopher Henry)

    2008-01-01

    Systems Engineers often conduct decision analysis in order to provide decision makers with a quantifiable means to make decisions. However, the field of Systems Engineering is often criticized for focusing on processes and ...

  17. The impact and dynamics of centralization in supply chain decision-making

    E-Print Network [OSTI]

    Sohn, Tae-Hee

    2008-01-01

    Companies with a corporate supply chain department and multiple business units use one of two methods for their supply chain decision-making: centralized decision-making where supply chain decisions are made at the corporate ...

  18. The Role of GIS in Decision Support Systems | Department of Energy

    Office of Environmental Management (EM)

    The Role of GIS in Decision Support Systems The Role of GIS in Decision Support Systems The Role of GIS in Decision Support Systems More Documents & Publications Microsoft Word -...

  19. Delegation in Tourism Decision Making: Toward an Understanding of the Role of Social Surrogate 

    E-Print Network [OSTI]

    Stone, Matthew John

    2014-07-30

    Tourism is often a group-based activity, but tourism decision-making research has primarily focused on individual decision making and who makes decisions in families. However, there are numerous situations in which individuals ...

  20. Title and author(s) Notes on Human Error Analysis and

    E-Print Network [OSTI]

    calibration and testing as found in the US Licensee Event Reports. Available on request from Risø Library JUDGEMENT 4 "HUMAN ERROR" - DEFINITION AND CLASSIFICATION 6 RELIABILITY AND SAFETY ANALYSIS 10 HUMAN FACTORS

  1. Policy Responses to Human Trafficking in Southern Africa: Domesticating International Norms

    E-Print Network [OSTI]

    Britton, Hannah E.; Dean, Laura A.

    2014-01-01

    Human trafficking is increasingly recognized as an outcome of economic insecurity, gender inequality, and conflict, all significant factors in the region of southern Africa. This paper examines policy responses to human trafficking in southern...

  2. Technology Decisions Under Architectural Uncertainty: Informing Investment Decisions Through Tradespace Exploration

    E-Print Network [OSTI]

    Battat, Jonathan A.

    Although NASA has yet to choose an architecture for human spaceflight beyond Earth orbit, they must pursue near-term investment in the enabling technologies that will be required for these future systems. Given this ...

  3. KRFTWRK – Global Human Electricity

    E-Print Network [OSTI]

    Prohaska, Rainer

    2009-01-01

    in the generation of human power, where energy is gained byparticipant runs a virtual human power plant. Per every "by muscle-power and chemical processes of human bodies. For

  4. Amended Record of Decision: Idaho High-Level Waste and Facilities...

    Office of Environmental Management (EM)

    of Decision: Idaho High-Level Waste and Facilities Disposition Final Environmental Impact Statement AGENCY: Department of Energy. ACTION: Amended Record of Decision. SUMMARY:...

  5. Computational-Process Modelling of Household Travel Decisions Using a Geographical Information System

    E-Print Network [OSTI]

    Golledge, Reginald G.; Kwan, Mei-Po; Garling, Tommy

    1994-01-01

    Journal of Geographical Information Systems 3:215-232.Decisions Using a Geographical Information System ReginaldDecisions Using a Geographical Information System Reginald

  6. On-Board Fuel Processing Go No-Go Decision, August 2004

    Fuel Cell Technologies Publication and Product Library (EERE)

    DOE Decision Report on Go/No-go decision on on-board fuel processing task for fuel cell vehicles. Revised report published August 2004.

  7. Reproducing human decisions in reservoir management: the case of lake Lugano

    E-Print Network [OSTI]

    Corani, Giorgio

    irrigation of agricultural fields, to drinking water sup- ply, hydroelectric power production, and even as a multi-objective optimization problem (Soncini et al., 2007). Yet, the design of complex and large reservoir might be ruled by an optimized policy, while smaller ones are still regulated by hand

  8. The MX Factor

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MX Factor Test films played a strategic-planning role in the debates of the late 1970s and early 1980s about where and how to deploy the MX intercontinental ballistic missile...

  9. Power Factor Improvement 

    E-Print Network [OSTI]

    Viljoen, T. A.

    1979-01-01

    and disadvantages of various locations in the electrical network are described including the cost of installation and network capacity improvement. Sizing of capacitors is also covered. Finally, some case studies involving power factor improvement are presented...

  10. Reducing Power Factor Cost

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Before PF 100142 0.70 or 70% After PF 100105 0.95 or 95% PB References: B.C. Hydro. Power Factor. The GEM Series. October 1989. Commonwealth Sprague Capacitor, Inc....

  11. Electromagetic proton form factors

    E-Print Network [OSTI]

    M Y Hussein

    2006-10-31

    The electromagnetic form factors are crucial to our understanding of the proton internal structure, and thus provide a strong constraint of the distributions of the charge and magnetization current within the proton. We adopted the quark-parton model for calculating and understanding the charge structure of the proton interms of the electromagnetic form factors. A remarkable agreement with the available experimental evidence is found.

  12. Optimizing Power Factor Correction 

    E-Print Network [OSTI]

    Phillips, R. K.; Burmeister, L. C.

    1986-01-01

    FACTOR CORRECTION Robert K. Phillips and Louis C. Burmeister, Mechanical Engineering, University of Kansas, Lawrence, KS The optimal investment for power factor correcting capacitors for Kansas Power and Light Company large power contract customers... consumer of electricity were made for demands of 200, 400, 800, 1,600, 3,200, and 6,400 k\\~ and monthly energy consumption periods of 100, 150, 200, 300, 400, and 500 hours for several capacitor purchase and installation costs. The results...

  13. FGF growth factor analogs

    DOE Patents [OSTI]

    Zamora, Paul O. (Gaithersburg, MD); Pena, Louis A. (Poquott, NY); Lin, Xinhua (Plainview, NY); Takahashi, Kazuyuki (Germantown, MD)

    2012-07-24

    The present invention provides a fibroblast growth factor heparin-binding analog of the formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.

  14. Jefferson Lab Human Resources

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Resources The Human Resources team is fully integrated with Jefferson Lab's mission, committed to providing quality customer service based on expertise, innovation and...

  15. Economics and Decision-Making for Climate Change and Sustainability

    E-Print Network [OSTI]

    Schmittner, Andreas

    summer on record ·Polar bears could disappear within a century ·Global warming, economic decisions are driving phenomena such as global warming and biodiversity is a global externality ­ very difficult to tackle from an economic point of view

  16. Introducing Impact Analysis for Architectural Decisions Matthias Riebisch, Sven Wohlfarth

    E-Print Network [OSTI]

    Riebisch, Matthias

    of the architectural decisions during the development and evolution of systems of this kind are frequently called are the definition of a middleware plat- form, of a database management system (DBMS) or an architectural style

  17. Developing an alternative model for travel decision-making 

    E-Print Network [OSTI]

    Hung, Kam

    2009-05-15

    This study proposes an alternative travel decision making model and situates its arguments in the Motivation-Opportunity-Ability (MOA) theoretical construct. The MOA model suggests that motivation, opportunity, and ability ...

  18. A Note on Kirkwood's Algebraic Method for Decision Problems

    E-Print Network [OSTI]

    Guo, Rui; Shenoy, Prakash P.

    1996-09-20

    The main objectives of this note are to point out some strengths and some limitations of Kirkwood's algebraic method for decision problems, and to propose a modification to address the limitations. The modification is based ...

  19. The Role of Electricity Pricing Policy in Industrial Siting Decisions 

    E-Print Network [OSTI]

    Tam, C. S.

    1981-01-01

    policy of electricity plays a significant role in the siting decisions of energy intensive industries, it is therefore imperative for the policy makers to understand the long term impact of their policies. This paper will examine the current pricing...

  20. Making a Decision to Intervene: Adaptive Guidelines to Humanitarian Intervention

    E-Print Network [OSTI]

    Ahmed, Ranya

    2011-12-31

    This thesis seeks to examine multilateral humanitarian intervention as a universal norm of international law, and analyze the decision making process, including the political and moral reasons, justifications, procedures, ...

  1. Periodicals collection management using a decision support system

    SciTech Connect (OSTI)

    Compton, M.L.; Moser, E.C.

    1993-12-31

    Sandia National Laboratories is a multiprogram national laboratory established in 1949. The Library currently uses DOBIS for its automated system, including the Periodicals Control function for periodical check-in. DOBIS performs processing and control functions adequately, but could not meet our reporting needs. Therefore the Library`s Periodicals Decision Team decided that they needed another ``system`` for collection management. A Periodicals Decision Support System was created using information downloaded from DOBIS and uploaded into dBASE IV. The Periodical Decision Support System functions as an information-processing system that has aided us in making collection management decisions for periodicals. It certainly allows us to do interactive ad-hoc analysis; although there are no modeling tools currently incorporated in the system. We hope that these modeling tools will come later. We have been gathering information and developing needed reports to achieve this goal.

  2. Application Form Certificate Program in Risk, Uncertainty, and Decision Analysis

    E-Print Network [OSTI]

    Van Veen, Barry D.

    Application Form Certificate Program in Risk, Uncertainty, and Decision Analysis College _____________ Proposed Substitution _______________________________ _____________ Methods for Probabilistic Risk Analysis (3 credits): Industrial and Systems Engineering 574 Methods for Probabilistic Risk Analysis

  3. Summary of Decisions - June 1, 2015 - June 5, 2015 | Department...

    Broader source: Energy.gov (indexed) [DOE]

    (10 CFR Part 710) On June 1, 2015, an OHA Administrative Judge (AJ) issued a decision in which he concluded that the DOE should grant a security clearance to an individual. A DOE...

  4. Rangeland Risk Management for Texans: Making Better Decisions 

    E-Print Network [OSTI]

    White, Larry D.

    2000-11-01

    The commonsense guidelines in this publication can help rangeland managers make better decisions. They include being cautious about wishful thinking, being realistic about the value of your assets, and making sure you have all the facts....

  5. A framework for decision support in systems architecting

    E-Print Network [OSTI]

    Simmons, Willard Lennox

    2008-01-01

    The objective of this thesis is to provide a method and tool to leverage computational resources to empower a systems architect to reason about architectural decisions more comprehensively and effectively compared to ...

  6. Decision support systems for automated terminal area air traffic control

    E-Print Network [OSTI]

    Pararas, John Demetrios

    1982-01-01

    This work studies the automation of the terminal area Air Traffic Management and Control (ATM/C) system. The ATM/C decision-making process is analyzed and broken down into a number of "automation functions". Each of these ...

  7. Statistical learning for decision making : interpretability, uncertainty, and inference

    E-Print Network [OSTI]

    Letham, Benjamin

    2015-01-01

    Data and predictive modeling are an increasingly important part of decision making. Here we present advances in several areas of statistical learning that are important for gaining insight from large amounts of data, and ...

  8. Reliability improvement project decision making : water cooling system redesign

    E-Print Network [OSTI]

    Devine, Paul (Paul S.)

    2006-01-01

    Deciding on which reliability & performance improvement projects to launch or to reject has historically been an extremely challenging responsibility of Teradyne management. Incorrect decisions can lead to major customer ...

  9. On Committee Decision Making: A Game Theoretical Approach

    E-Print Network [OSTI]

    Shenoy, Prakash P.

    1980-04-01

    In this paper, we study committee decision making process using game theory. By a committee, we mean any group of people who have to pick one option from a given set of alternatives. A well defined voting rule is specified ...

  10. Decision-making under Ambiguity in Neurodegenerative Disease 

    E-Print Network [OSTI]

    Rogers, Denise

    2011-11-23

    Decision-making is a complex skill that is essential for daily life. Yet the complexities of this process are often overlooked in favour of more obvious cognitive deficits during neuropsychological assessment, such as ...

  11. Balancing influence between actors in healthcare decision making

    E-Print Network [OSTI]

    Kaplan, Robert M; Babad, Yair M

    2011-01-01

    Kaplan and Babad BMC Health Services Research 2011, 11:85decision making Robert M Kaplan 1* and Yair M Babad 22006, 355(9):920-927. 16. Kaplan RM: Measuring quality of

  12. Establishment of Management Decisions on Office of Inspector General Reports

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2001-12-17

    To establish the responsibilities and requirements for Department of Energy (DOE) action required to make management decisions on Office of Inspector General (OIG) audit and public inspection reports. Cancels DOE 2320.2B

  13. Robust decision-support tools for airport surface traffic

    E-Print Network [OSTI]

    Carr, Francis R. (Francis Russell), 1976-

    2004-01-01

    Forecasts of departure demand are one of the driving inputs to tactical decision-support tools (DSTs) for airport surface traffic. While there are well-known results on average- or worst-case forecast uncertainty, it is ...

  14. Robust Decision-Support Tools for Airport Surface Traffic

    E-Print Network [OSTI]

    Carr, Francis R.

    Forecasts of departure demand are one of the driving inputs to tactical decision-support tools (DSTs) for airport surface traffic. While there are well-known results on average- or worst-case forecast uncertainty, it is ...

  15. Establishment of Management Decisions on Office of Inspector General Reports

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-04-19

    The order establishes the responsibilities and requirements for Department of Energy elements to make management decisions on Office of Inspector General audits and public inspection reports. Supersedes DOE O 221.3.

  16. Record of Decision; Defense Waste Processing Facility at the...

    Office of Environmental Management (EM)

    8:45 am BILLING CODE 4000-01-M DEPARTMENT OF ENERGY Record of Decision; Defense Waste Processing Facility at the Savannah River Site, Aiken, SC AGENCY: Department of...

  17. Energy Signal Tool for Decision Support in Building Energy Systems...

    Office of Scientific and Technical Information (OSTI)

    Signal Tool for Decision Support in Building Energy Systems Henze, G. P.; Pavlak, G. S.; Florita, A. R.; Dodier, R. H.; Hirsch, A. I. 32 ENERGY CONSERVATION, CONSUMPTION, AND...

  18. Scientia : An end user development environment for decision support systems/

    E-Print Network [OSTI]

    Sims, Clayton Tyler

    2009-01-01

    This thesis describes an end user programming environment that allows non-programmers to create decision support protocols for use on electronic devices. User centered design techniques were followed to identify the ...

  19. EIS-0226: Revision to the Record of Decision | Department of...

    Broader source: Energy.gov (indexed) [DOE]

    of Decision for the Department of Energy's Waste Isolation Pilot Plant Disposal Phase (WIPP ROD), 63 FR 3624 (Jan. 23, 1998). DOE has decided to dispose of up to 2,500 cubic...

  20. A DECISION SUPPORT SYSTEM (DSS) FOR STORMWATER MANAGEMENT SYSTEM SELECTION

    E-Print Network [OSTI]

    A DECISION SUPPORT SYSTEM (DSS) FOR STORMWATER MANAGEMENT SYSTEM SELECTION BY ANGIE SHELLEY MILES B...................................................................................................... 1 1.1 History of Stormwater Regulations............................................................................................................ 7 2.1 Stormwater DSS Development

  1. Value stream financial modeling for improved production decision making

    E-Print Network [OSTI]

    Hopkins, Christopher Warren

    2011-01-01

    Understanding the overall impact of a decision in a manufacturing system can be challenging given the complex production and financial structures in today's companies. While knowing the direct result of a local change may ...

  2. Including costs of supply chain risk in strategic sourcing decisions

    E-Print Network [OSTI]

    Jain, Avani

    2009-01-01

    Cost evaluations do not always include the costs associated with risks when organizations make strategic sourcing decisions. This research was conducted to establish and quantify the impact of risks and risk-related costs ...

  3. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan Ogden and Lorraine Anderson #12;Institute of Transportation Studies University of California, Davis One SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS CHAPTER 12: KEY MEASUREMENT UNCERTAINTIES FOR BIOFUEL POLICY

  4. Bounded Parameter Markov Decision Processes with Average Reward Criterion

    E-Print Network [OSTI]

    Tewari, Ambuj

    Bounded Parameter Markov Decision Processes with Average Reward Criterion Ambuj Tewari1 and Peter L, pp. 263­277, 2007. c Springer-Verlag Berlin Heidelberg 2007 #12;264 A. Tewari and P.L. Bartlett

  5. Decision-making processes in shipping acquisitions and shipbuilding

    E-Print Network [OSTI]

    Maroulis, Vasileios

    2004-01-01

    The purpose of this thesis is to expand and analyze the decisions that are constantly being made by shipping companies concerning acquisition of newbuildings, the construction of newbuildings, operational aspects as well ...

  6. The Influence of Regulation on the Decision to Cogenerate 

    E-Print Network [OSTI]

    King, J. L. II

    1986-01-01

    OF REGULATION ON THE DECISION TO COGENERATE Joe L. King II* Public Utility Commission of Texas Austin, Texas ABSTRACT This paper will be primarily on the Public Utility Commission of Texas' Substantive Rules that explicitly address cogeneration... and future ratepayers. Discussion will focus on how the existing rules can directly influence the decision to cogenerate. Part One provides a brief history of the Section 23.66 rules. Part Two discusses the pricing methodology adopted by the Commission...

  7. The SACADA database for human reliability and human performance

    SciTech Connect (OSTI)

    Y. James Chang; Dennis Bley; Lawrence Criscione; Barry Kirwan; Ali Mosleh; Todd Madary; Rodney Nowell; Robert Richards; Emilie M. Roth; Scott Sieben; Antonios Zoulis

    2014-05-01

    Lack of appropriate and sufficient human performance data has been identified as a key factor affecting human reliability analysis (HRA) quality especially in the estimation of human error probability (HEP). The Scenario Authoring, Characterization, and Debriefing Application (SACADA) database was developed by the U.S. Nuclear Regulatory Commission (NRC) to address this data need. An agreement between NRC and the South Texas Project Nuclear Operating Company (STPNOC) was established to support the SACADA development with aims to make the SACADA tool suitable for implementation in the nuclear power plants' operator training program to collect operator performance information. The collected data would support the STPNOC's operator training program and be shared with the NRC for improving HRA quality. This paper discusses the SACADA data taxonomy, the theoretical foundation, the prospective data to be generated from the SACADA raw data to inform human reliability and human performance, and the considerations on the use of simulator data for HRA. Each SACADA data point consists of two information segments: context and performance results. Context is a characterization of the performance challenges to task success. The performance results are the results of performing the task. The data taxonomy uses a macrocognitive functions model for the framework. At a high level, information is classified according to the macrocognitive functions of detecting the plant abnormality, understanding the abnormality, deciding the response plan, executing the response plan, and team related aspects (i.e., communication, teamwork, and supervision). The data are expected to be useful for analyzing the relations between context, error modes and error causes in human performance.

  8. CORRRECTIVE ACTION DECISION DOCUMENT FOR CORRECTIVE ACTION UNIT 427: AREA 3 SEPTIC WASTE SYSTEMS 2 AND 6, TONOPAH TEST RANGE, NEVADA, REVISION 0, JUNE 1998

    SciTech Connect (OSTI)

    DOE /NV

    1998-06-23

    This Corrective Action Decision Document has been prepared for the Area 3 Septic Waste Systems 2 and 6 (Corrective Action Unit 427) in accordance with the Federal Facility Agreement and Consent Order of 1996 (FFACO, 1996). Corrective Action Unit 427 is located at the Tonopah Test Range, Nevada, and is comprised of the following Corrective Action Sites, each an individual septic waste system (DOE/NV, 1996a): (1) Septic Waste System 2 is Corrective Action Site Number 03-05-002-SW02. (2) Septic Waste System 6 is Corrective Action Site Number 03-05-002-SW06. The purpose of this Corrective Action Decision Document is to identify and provide a rationale for the selection of a recommended corrective action alternative for each Corrective Action Site. The scope of this Correction Action Decision Document consists of the following tasks: (1) Develop corrective action objectives. (2) Identify corrective action alternative screening criteria. (3) Develop corrective action alternatives. (4) Perform detailed and comparative evaluations of the corrective action alternatives in relation to the corrective action objectives and screening criteria. (5) Recommend and justify a preferred corrective action alternative for each CAS. From November 1997 through January 1998, a corrective action investigation was performed as set forth in the Corrective Action Investigation Plan for Corrective Action Unit No. 427: Area 3 Septic Waste System Numbers 2 and 6, Tonopah Test Range, Nevada (DOE/NV, 1997b). Details can be found in Appendix A of this document. The results indicated that contamination is present in some portions of the CAU and not in others as described in Table ES-1 and shown in Figure A.2-2 of Appendix A. Based on the potential exposure pathways, the following corrective action objectives have been identified for Corrective Action Unit 427: (1) Prevent or mitigate human exposure to subsurface soils containing TPH at concentrations greater than 100 milligrams per kilogram (NAC, 1996b). (2) Close Sep tic Tank 33-5 in accordance with Nevada Administrative Code 459 (NAC, 1996c). (3) Prevent adverse impacts to groundwater quality. Based on the review of existing data, future land use, and current operations at the Tonopah Test Range, the following alternatives were developed for consideration at the Area 3 Septic Waste Systems 2 and 6: Alternative 1 - No Further Action; Alternative 2 - Closure of Septic Tank 33-5 and Administrative Controls; Alternative 3 - Closure of Septic Tank 33-5, Excavation, and Disposal The corrective action alternatives were evaluated based on four general corrective action standards and five remedy selection decision factors. Based on the results of this evaluation, the preferred alternative for Corrective Action Unit 427 is Alternative 2, Closure of Septic Tank 33-5 and Administrative Controls. The preferred corrective action alternative was evaluated on technical merit, focusing on performance, reliability, feasibility, and safety. The alternative was judged to meet all requirements for the technical components evaluated. The alternative meets all applicable state and federal regulations for closure of the site and will reduce potential future exposure pathways to the contaminated soils. During corrective action implementation, this alternative will present minimal potential threat to site workers who come in contact with the waste. However, procedures will be developed and implemented to ensure worker health and safety.

  9. Predicting Human Performance for Face Recognition1 Alice J. O'Toole Fang Jiang

    E-Print Network [OSTI]

    O'Toole, Alice J.

    the factors that affect human accuracy. These factors can be classified into facial stucture constraints then be possible to apply these principles to the design of algorithms to meet the pressing challenges of face

  10. Decision Support for IntegratedDecision Support for Integrated WaterWater--Energy PlanningEnergy Planning

    E-Print Network [OSTI]

    Keller, Arturo A.

    · Thermoelectric cooling · Hydropower · Extraction and refining · Fuel production (ethanol, hydrogen) Estimated -Cost Regulators -Air Quality -Water Quality -Instream Flows -Water Rights -Energy Reliability development: · Identify metrics and variables, · System conceptualization, and · Model review. ­ Decision

  11. Finding Common Ground: Exploring the Experiences of Client Involvement in Medication Decisions Using a Shared Decision Making Model

    E-Print Network [OSTI]

    Goscha, Richard J.

    2009-12-01

    medications. Purposeful sampling, with an emphasis on achieving maximum variation, was used to better understand the interactive processes that contribute to as well as hinder client involvement in shared decision making. Multiple interviews with all...

  12. Decision-Making to Reduce Manufacturing Greenhouse Gas Emissions

    E-Print Network [OSTI]

    Reich-Weiser, Corinne

    2010-01-01

    governance in managing ecosystem service trade-offs,” International Human Dimensions Programme on Global Environmental

  13. human spaceflight and operations

    E-Print Network [OSTI]

    Anand, Mahesh

    1 human spaceflight and operations Lunar Lander human spaceflight and operations #12;2 human cooperation in exploration prim ary objective opportunity for investigations #12;3 human spaceflight No RHUs LANDING SITE South Polar Reliant on Solar Power generation + conventional thermal control LAUNCHER

  14. Analysis of Human Genetic Linkage

    SciTech Connect (OSTI)

    Boehnke, M.

    1991-01-01

    Linkage analysis continues in its golden age. The convergence of several factors - advances in molecular biology, advances in statistical models and algorithms, and advances in computing technology - have made possible remarkable successes in the mapping of human genetic diseases and in the construction of human genetic maps. The goals of mapping all the most important simple Mendelian disorders and constructing fine-structure genetic maps for each of the human chromosomes soon will be reached, and linkage methods promise to help us understand the etiologies of many common and complex familial diseases. With the continuing rapid advance of the field, the appearance of the revised edition of Dr. Ott's book is particularly welcome. As with the first edition, the goal of the revised edition is to provide a concise, easy-to-read introduction to human linkage analysis. The revised edition includes chapters on basic genetics and cytogenetics, genes and genetic polymorphisms, aspects of statistical inference, methods of linkage analysis, the informativeness of family data, multipoint linkage analysis, penetrance, numerical and computerized methods, the variability of the recombination fraction, inconsistencies, and linkage analysis with disease loci. The results is not an encyclopedia providing everything one could ever want to know about linkage analysis but, rather, a guide to the important methods, topics, and problems of linkage analysis today. Overall, the book achieves an excellent compromise between presenting important conclusions and working out the details.

  15. A technique for human error analysis (ATHEANA)

    SciTech Connect (OSTI)

    Cooper, S.E.; Ramey-Smith, A.M.; Wreathall, J.; Parry, G.W. [and others

    1996-05-01

    Probabilistic risk assessment (PRA) has become an important tool in the nuclear power industry, both for the Nuclear Regulatory Commission (NRC) and the operating utilities. Human reliability analysis (HRA) is a critical element of PRA; however, limitations in the analysis of human actions in PRAs have long been recognized as a constraint when using PRA. A multidisciplinary HRA framework has been developed with the objective of providing a structured approach for analyzing operating experience and understanding nuclear plant safety, human error, and the underlying factors that affect them. The concepts of the framework have matured into a rudimentary working HRA method. A trial application of the method has demonstrated that it is possible to identify potentially significant human failure events from actual operating experience which are not generally included in current PRAs, as well as to identify associated performance shaping factors and plant conditions that have an observable impact on the frequency of core damage. A general process was developed, albeit in preliminary form, that addresses the iterative steps of defining human failure events and estimating their probabilities using search schemes. Additionally, a knowledge- base was developed which describes the links between performance shaping factors and resulting unsafe actions.

  16. Multi-factor authentication

    DOE Patents [OSTI]

    Hamlet, Jason R; Pierson, Lyndon G

    2014-10-21

    Detection and deterrence of spoofing of user authentication may be achieved by including a cryptographic fingerprint unit within a hardware device for authenticating a user of the hardware device. The cryptographic fingerprint unit includes an internal physically unclonable function ("PUF") circuit disposed in or on the hardware device, which generates a PUF value. Combining logic is coupled to receive the PUF value, combines the PUF value with one or more other authentication factors to generate a multi-factor authentication value. A key generator is coupled to generate a private key and a public key based on the multi-factor authentication value while a decryptor is coupled to receive an authentication challenge posed to the hardware device and encrypted with the public key and coupled to output a response to the authentication challenge decrypted with the private key.

  17. Geothermal Plant Capacity Factors

    SciTech Connect (OSTI)

    Greg Mines; Jay Nathwani; Christopher Richard; Hillary Hanson; Rachel Wood

    2015-01-01

    The capacity factors recently provided by the Energy Information Administration (EIA) indicated this plant performance metric had declined for geothermal power plants since 2008. Though capacity factor is a term commonly used by geothermal stakeholders to express the ability of a plant to produce power, it is a term frequently misunderstood and in some instances incorrectly used. In this paper we discuss how this capacity factor is defined and utilized by the EIA, including discussion on the information that the EIA requests from operations in their 923 and 860 forms that are submitted both monthly and annually by geothermal operators. A discussion is also provided regarding the entities utilizing the information in the EIA reports, and how those entities can misinterpret the data being supplied by the operators. The intent of the paper is to inform the facility operators as the importance of the accuracy of the data that they provide, and the implications of not providing the correct information.

  18. Human choice and climate change. Four volume set

    SciTech Connect (OSTI)

    Rayner, S.; Malone, E.L.

    1997-12-31

    The four-volume set assesses social science research relevant to global climate change from a wide-ranging interdisciplinary perspective. Taking human choice within social institutions as the starting point, noted researchers examine climate change issues in the context of societal issues such as population and consumption; cultural, institutional, and economic arrangements for human well-being; and the social processes by which decisions are made from local to global levels. This four-volume assessment is intended to complement the work of the intergovernmental Panel on Climate Change.

  19. EIS-0312 DOE Notice of Availability of the Record of Decision

    Broader source: Energy.gov [DOE]

    Bonneville Power Administration Fiscal Years 2007–2009 Fish and Wildlife Project Implementation Decision

  20. EIS-0312: DOE Notice of Availability of the Record of Decision

    Broader source: Energy.gov [DOE]

    Bonneville Power Administration Fiscal Year 2007–2009 Fish and Wildlife Project Implementation Decision

  1. Design as a Set of Design Decisions Remco C. de Boer

    E-Print Network [OSTI]

    van Vliet, Hans

    Design as a Set of Design Decisions Remco C. de Boer ArchiXL The Netherlands Email: rdeboer is characterized by the major design decisions taken. These major design decisions tend to be quality-related. We studied the videos to identify those major design decisions. We found that each design team made one

  2. XML-Tage 2006 A KNOWLEDGE BASE ON NP-COMPLETE DECISION

    E-Print Network [OSTI]

    Niedermeier, Rolf

    of more than 350 decision problems including additional information resources such as bibli- ographic

  3. A Simulation and Decision Analysis Approach to Locating DNAPLS in Subsurface Sediments

    E-Print Network [OSTI]

    Borchers, Brian

    of DNAPL spills with a decision analysis model to pick optimal locations for sampling wells. In this paper the decision tree. Use the decision tree solution to pick the next well location. Drill the well, collect data with a decision analysis model to pick optimal locations for sampling wells. Our strategy is an iterative process

  4. An Argumentation-based Approach to Handling Trust in Distributed Decision Simon Parsons and Elizabeth Sklar

    E-Print Network [OSTI]

    California at Davis, University of

    information from particu- lar sources impacts the decisions they have to make. We de- scribe the formal system to support decision making in situations where the source of the information on which decisions are based concentrate, in particular, on the trust that decision-makers have in information sources. The approach

  5. Composition, Digestibility and Energy Values of Some Human Foods. 

    E-Print Network [OSTI]

    Fraps, G. S. (George Stronach)

    1946-01-01

    STATION C. H. McDOWELL, ACTING DIRECTOR College Station, Texas BULLETIN NO. 680 AUGUST, 1946 COMPOSITION, DIGESTIBILITY AND ENERGY VALUES OF SOME HUMAN FOODS G. S. FRAPS Division of Chemistry AGRICULTURAL AND MECHANICAL COLLEGE OF TEXAS GIBB..., the average digestibility of human foods as compiled from the literature, factors for calculating the metabolizable energy and productive energy of human foods, a comparison of the fuel values as usually calculated with the metabolizable energy...

  6. Fast Factoring of Integers

    E-Print Network [OSTI]

    Gordon Chalmers

    2005-09-20

    An algorithm is given to factor an integer with $N$ digits in $\\ln^m N$ steps, with $m$ approximately 4 or 5. Textbook quadratic sieve methods are exponentially slower. An improvement with the aid of an a particular function would provide a further exponential speedup.

  7. Limiting human exposures through the ``as low as reasonably achievable`` process at a Department of Energy mixed waste site

    SciTech Connect (OSTI)

    MacDonell, M.; Peterson, J.; Haroun, L.; Blunt, D.; Dunning, D.

    1994-09-01

    Applying a process to reduce human exposures to levels as low as reasonably achievable (ALARA) is a cornerstone of the US Department of Energy`s radiation protection program, and this process is being used to develop cleanup levels for contaminated sites across the country. Under the ALARA process, exposures and risks are reduced as far below protective criteria as can reasonably be achieved--considering technical, economic, and social factors. Risk-based cleanup levels have been developed for radionuclides and chemicals in surface water and soil at the Weldon Spring site in Missouri, following explicit applications of the ALARA process. Among the lessons learned during these applications were the importance of three factors: (1) soliciting early input from the parties involved--because the ALARA process involves a range of technical and nontechnical issues; (2) maintaining site specificity for the ALARA analyses--because contaminant types and distributions will vary, as will local conditions and constraints; and (3) identifying cleanup levels in the planning phase that are distinct from those developed for the field phase--because remedies can be over-designed if the decision levels are the same as the ALARA goals for field work, such that little increased risk reduction is achieved for substantially higher costs.

  8. Superfund record of decision (EPA Region 4): Paducah Gaseous Diffusion Plant (USDOE), Operable Unit 15, Paducah, KY, August 10, 1998

    SciTech Connect (OSTI)

    NONE

    1998-12-01

    This decision document presents the remedial action for the Solid Waste Management Unit (SWMU) 91 of the Waste Area Group (WAG) 27 at the Paducah Gaseous Diffusion Plant (PGDP) near Paducah, Kentucky. The primary objective of this remedial action is to reduce the level of TCE-contaminated soil thereby reducing the potential future concentrations in ground water that could pose a threat to human health and the environment at the POE (i.e., the DOE property boundary). The potential for migration of the contamination from the soil of the off-site aquifer is the concern associated with the SWMU.

  9. Matrix Factorization and Matrix Concentration

    E-Print Network [OSTI]

    Mackey, Lester

    2012-01-01

    PCA 3 Mixed Membership Matrix Factorization 3.15.2 Matrix concentration3.3 Mixed Membership Matrix Factorization . . . 3.4

  10. CORRECTIVE ACTION DECISION DOCUMENT FOR THE AREA 3 LANDFILL COMPLEX, TONOPAH TEST RANGE, CAU 424, REVISION 0, MARCH 1998

    SciTech Connect (OSTI)

    DOE /NV

    1998-03-03

    This Corrective Action Decision Document (CADD) has been prepared for the Area 3 Landfill Complex (Corrective Action Unit [CAU] 424) in accordance with the Federal Facility Agreement and Consent Order (FFACO) of 1996. Corrective Action Unit 424 is located at the Tonopah Test Range (TTR) and is comprised of the following Corrective Action Sites (CASs), each an individual landfill located around and within the perimeter of the Area 3 Compound (DOE/NV, 1996a): (1) Landfill A3-1 is CAS No. 03-08-001-A301. (2) Landfill A3-2 is CAS No. 03-08-002-A302. (3) Landfill A3-3 is CAS No. 03-08-002-A303. (4) Landfill A3-4 is CAS No. 03-08-002-A304. (5) Landfill A3-5 is CAS No. 03-08-002-A305. (6) Landfill A3-6 is CAS No. 03-08-002-A306. (7) Landfill A3-7 is CAS No. 03-08-002-A307. (8) Landfill A3-8 is CAS No. 03-08-002-A308. The purpose of this CADD is to identify and provide a rationale for the selection of a recommended corrective action alternative for each CAS. The scope of this CADD consists of the following: (1) Develop corrective action objectives. (2) Identify corrective action alternative screening criteria. (3) Develop corrective action alternatives. (4) Perform detailed and comparative evaluations of the corrective action alternatives in relation to the corrective action objectives and screening criteria. (6) Recommend and justify a preferred corrective action alternative for each CAS. In June and July 1997, a corrective action investigation was performed as set forth in the Corrective Action Investigation Plan (CAIP) for CAU No. 424: Area 3 Landfill Complex, Tonopah Test Range, Nevada (DOE/NV, 1997). Details can be found in Appendix A of this document. The results indicated four groupings of site characteristics as shown in Table ES-1. Based on the potential exposure pathways, the following corrective action objectives have been identified for CAU No. 424: (1) Prevent or mitigate human exposure to subsurface soils containing waste. (2) Remediate the site per applicable state and federal regulations (NAC, 1996c). (3) Prevent adverse impacts to groundwater quality. Based on the review of existing data, future land use, and current operations at the TTR, the following alternatives were developed for consideration at the Area 3 Landfill Complex CAU: Alternative 1 - No Action; Alternative 2 - Administrative Closure; Alternative 3 - Partial Excavation, Backfill, and Recontouring The corrective action alternatives were evaluated based on four general corrective action standards and five remedy-selection decision factors. Based on the results of this evaluation, preferred alternatives were selected for each CAS as indicated in Table ES-2. The preferred corrective action alternatives were evaluated on their technical merits, focusing on performance, reliability, feasibility, and safety. The alternatives were judged to meet all requirements for the technical components evaluated. These alternatives meet all applicable state and federal regulations for closure of the site and will reduce potential future exposure pathways to the contents of the landfills. During corrective action implementation, these alternatives will present minimal potential threat to site workers who come in contact with the waste. However, procedures will be developed and implemented to ensure worker health and safety.

  11. Mexican-Origin Interregional Migration from the Southwest: Human, Household, and Community Capital Hypotheses 

    E-Print Network [OSTI]

    Siordia, Carlos

    2010-01-16

    their neighborhood and make residential location decisions (Ellis, Wright, & Parks 2006). The key difference between human and household social capital is that in general terms human capital theory focuses on the individual?s characteristics while household social... geographic areas to another. For example, the core?s grip can be seen as loosening its grip on the Mexican-origin population at the beginning of the 20 th century when agricultural, manufacturing, and railroad industries produced several pull forces...

  12. A Decision Support System for Optimum Use of Fertilizers

    SciTech Connect (OSTI)

    Hoskinson, Reed Louis; Hess, John Richard; Fink, Raymond Keith

    1999-07-01

    The Decision Support System for Agriculture (DSS4Ag) is an expert system being developed by the Site-Specific Technologies for Agriculture (SST4Ag) precision farming research project at the INEEL. DSS4Ag uses state-of-the-art artificial intelligence and computer science technologies to make spatially variable, site-specific, economically optimum decisions on fertilizer use. The DSS4Ag has an open architecture that allows for external input and addition of new requirements and integrates its results with existing agricultural systems’ infrastructures. The DSS4Ag reflects a paradigm shift in the information revolution in agriculture that is precision farming. We depict this information revolution in agriculture as an historic trend in the agricultural decision-making process.

  13. Top-down and bottom-up definitions of human failure events in human reliability analysis

    SciTech Connect (OSTI)

    Boring, Ronald Laurids

    2014-10-01

    In the probabilistic risk assessments (PRAs) used in the nuclear industry, human failure events (HFEs) are determined as a subset of hardware failures, namely those hardware failures that could be triggered by human action or inaction. This approach is top-down, starting with hardware faults and deducing human contributions to those faults. Elsewhere, more traditionally human factors driven approaches would tend to look at opportunities for human errors first in a task analysis and then identify which of those errors is risk significant. The intersection of top-down and bottom-up approaches to defining HFEs has not been carefully studied. Ideally, both approaches should arrive at the same set of HFEs. This question is crucial, however, as human reliability analysis (HRA) methods are generalized to new domains like oil and gas. The HFEs used in nuclear PRAs tend to be top-down—defined as a subset of the PRA—whereas the HFEs used in petroleum quantitative risk assessments (QRAs) often tend to be bottom-up—derived from a task analysis conducted by human factors experts. The marriage of these approaches is necessary in order to ensure that HRA methods developed for top-down HFEs are also sufficient for bottom-up applications.

  14. Competing with Humans at Fantasy Football: Team Formation in Large Partially-Observable Domains

    E-Print Network [OSTI]

    Chalkiadakis, Georgios

    Competing with Humans at Fantasy Football: Team Formation in Large Partially-Observable Domains Tim the framework of a class of online football prediction games known as Fantasy Football. We model the problem and where the decision maker's be- liefs are over multiple characteristics of each footballer. We

  15. Low-resolution Human Detection and Gait Recognition in Natural Scenes

    E-Print Network [OSTI]

    Li, Yongmin

    generated in the Haar cascade's response space. To find these maxima, we employ an augmented Mean Shift-level classification. Detecting human figures is formulated as a problem of finding maxima of the distribution's response from the decision boundary. This confidence is incorporated in the Mean Shift formula to direct

  16. Designing a Human-Centered, Multimodal GIS Interface to Support Emergency Management

    E-Print Network [OSTI]

    Klippel, Alexander

    Designing a Human-Centered, Multimodal GIS Interface to Support Emergency Management Ingmar; however conventional GIS are not suited for multi-user access and high- level abstract queries. Currently, decision makers do not always have the real time information they need; GIS analysts produce maps

  17. Deuteron Form Factor

    SciTech Connect (OSTI)

    Farrar, G.R.; Huleihel, K.; Zhang, H. (Department of Physics and Astronomy, Rutgers University, Piscataway, New Jersey 08855 (United States))

    1995-01-30

    We obtain the perturbative QCD (PQCD) prediction for the leading twist deuteron form factor, treated as a pair of nucleons in nonrelativistic bound state. It is [lt]10[sup [minus]3] times experiment at [ital Q][sup 2]=4 GeV[sup 2], suggesting that PQCD is not relevant to the deuteron form factor at present values of [ital Q][sup 2], or that non-nucleon (e.g., hidden color'') degrees of freedom must be included for a correct description of the deuteron. The tree-level amplitude [similar to][ital eg][sup 10] and is the sum of several 10[sup 6] Feynman diagrams, making it an interesting case study in the behavior of perturbation theory.

  18. Risk Analysis and Decision Making FY 2013 Milestone Report

    SciTech Connect (OSTI)

    Engel, David W.; Dalton, Angela C.; Dale, Crystal; Jones, Edward; Thompson, J.

    2013-06-01

    Risk analysis and decision making is one of the critical objectives of CCSI, which seeks to use information from science-based models with quantified uncertainty to inform decision makers who are making large capital investments. The goal of this task is to develop tools and capabilities to facilitate the development of risk models tailored for carbon capture technologies, quantify the uncertainty of model predictions, and estimate the technical and financial risks associated with the system. This effort aims to reduce costs by identifying smarter demonstrations, which could accelerate development and deployment of the technology by several years.

  19. Pricing postselection: the cost of indecision in decision theory

    E-Print Network [OSTI]

    Joshua Combes; Christopher Ferrie

    2015-04-14

    Postselection is the process of discarding outcomes from statistical trials that are not the event one desires. Postselection can be useful in many applications where the cost of getting the wrong event is implicitly high. However, unless this cost is specified exactly, one might conclude that discarding all data is optimal. Here we analyze the optimal decision rules and quantum measurements in a decision theoretic setting where a pre-specified cost is assigned to discarding data. We also relate our formulation to previous approaches which focus on minimizing the probability of indecision.

  20. Two Axiomatic Approaches to Decision Making Using Possibility Theory

    E-Print Network [OSTI]

    Giang, Phan H.; Shenoy, Prakash P.

    2005-04-16

    } min(? i ,? i (x)). (1) See [3]for more details. To the decision maker, the value of decision d is the same as the value of the induced lottery ? d . And thanks to the mixture construct, the set ? X is rich enough to encode not only a simple lottery... mapping from uncertainty scale V onto util- ity scale U such that h(1) = 1 and h(0) = 0. A pessimistic qualitative utility function QU ? :? X ?U is de?ned as follows: QU ? (?) def =min x?X max(nh(?(x)),u(x)) (5) where nh def = n?h is composition of n and h...

  1. EIS-0246: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum Based|Department of5 Peer ReviewUse2:Decision6: Supplement7:: Record of Decision

  2. EIS-0269: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum Based|Department of5 Peer ReviewUse2:Decision6:NoticeRecord of Decision

  3. EIS-0279: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum Based|Department of5 PeerRecord of Decision EIS-0279: Record of Decision

  4. EIS-0332: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum Based|Department of5 PeerRecordRecord of Decision EIS-0332: Record of Decision

  5. Journal Information Journal Impact Factor

    E-Print Network [OSTI]

    Krejcí, Pavel

    Journal Information Journal Impact Factor 5-Year Journal Impact Factor Journal Self Cites Journal Immediacy Index Journal Cited Half-Life 2014 JCR Science Edition Journal: CZECHOSLOVAK MATHEMATICAL JOURNAL Mark Journal Title ISSN Total Cites Impact Factor 5-Year Impact Factor Immediacy Index Citable Items

  6. Journal Information Journal Impact Factor

    E-Print Network [OSTI]

    Krejcí, Pavel

    Journal Information Journal Impact Factor 5-Year Journal Impact Factor Journal Self Cites Journal Immediacy Index Journal Cited Half-Life 2012 JCR Science Edition Journal: CZECHOSLOVAK MATHEMATICAL JOURNAL Mark Journal Title ISSN Total Cites Impact Factor 5-Year Impact Factor Immediacy Index Citable Items

  7. Programming with human computation

    E-Print Network [OSTI]

    Little, Greg (Danny Greg)

    2011-01-01

    Amazon's Mechanical Turk provides a programmatically accessible micro-task market, allowing a program to hire human workers. This has opened the door to a rich field of research in human computation where programs orchestrate ...

  8. Patenting Human Evolution

    E-Print Network [OSTI]

    Torrance, Andrew W.

    2008-06-01

    to thorough analysis and debate prior to the imminent arrival of human genetic enhancement technologies. Otherwise, patent law may drive human evolution in directions either unplanned - or worse - undesired....

  9. Derivation of dose conversion factors for tritium

    SciTech Connect (OSTI)

    Killough, G. G.

    1982-03-01

    For a given intake mode (ingestion, inhalation, absorption through the skin), a dose conversion factor (DCF) is the committed dose equivalent to a specified organ of an individual per unit intake of a radionuclide. One also may consider the effective dose commitment per unit intake, which is a weighted average of organ-specific DCFs, with weights proportional to risks associated with stochastic radiation-induced fatal health effects, as defined by Publication 26 of the International Commission on Radiological Protection (ICRP). This report derives and tabulates organ-specific dose conversion factors and the effective dose commitment per unit intake of tritium. These factors are based on a steady-state model of hydrogen in the tissues of ICRP's Reference Man (ICRP Publication 23) and equilibrium of specific activities between body water and other tissues. The results differ by 27 to 33% from the estimate on which ICRP Publication 30 recommendations are based. The report also examines a dynamic model of tritium retention in body water, mineral bone, and two compartments representing organically-bound hydrogen. This model is compared with data from human subjects who were observed for extended periods. The manner of combining the dose conversion factors with measured or model-predicted levels of contamination in man's exposure media (air, drinking water, soil moisture) to estimate dose rate to an individual is briefly discussed.

  10. Human Reliability Considerations for Small Modular Reactors

    SciTech Connect (OSTI)

    OHara J. M.; Higgins, H.; DAgostino, A.; Erasmia, L.

    2012-01-27

    Small modular reactors (SMRs) are a promising approach to meeting future energy needs. Although the electrical output of an individual SMR is relatively small compared to that of typical commercial nuclear plants, they can be grouped to produce as much energy as a utility demands. Furthermore, SMRs can be used for other purposes, such as producing hydrogen and generating process heat. The design characteristics of many SMRs differ from those of current conventional plants and may require a distinct concept of operations. The U.S. Nuclear Regulatory Commission (NRC) conducted research to examine the human factors engineering and the operational aspects of SMRs. The research identified thirty potential human-performance issues that should be considered in the NRC's reviews of SMR designs and in future research activities. The purpose of this report is to illustrate how the issues can support SMR probabilistic risk analyses and their review by identifying potential human failure events for a subset of the issues. As part of addressing the human contribution to plant risk, human reliability analysis practitioners identify and quantify the human failure events that can negatively impact normal or emergency plant operations. The results illustrated here can be generalized to identify additional human failure events for the issues discussed and can be applied to those issues not discussed in this report.

  11. Human Functional Brain Imaging

    E-Print Network [OSTI]

    Rambaut, Andrew

    Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review #12;2 | Portfolio Review: Human Functional Brain ImagingThe Wellcome Trust is a charity registered in England and Wales, no's role in supporting human functional brain imaging and have informed `our' speculations for the future

  12. Developments in Human Communication

    E-Print Network [OSTI]

    Thompson, Michael

    CMST 1B03 Developments in Human Communication: Part & Present Amanda Etches-Johnson Mills Research in Human Communication Session Outline 1. Finding Books Using MORRIS 2. Finding Journal Articles using: Developments in Human Communication What is MORRIS anyway? · MORRIS is McMaster's library catalogue · Shows

  13. Integrating Human Performance and Technology

    SciTech Connect (OSTI)

    Ronald K. Farris; Heather Medema

    2012-05-01

    Human error is a significant factor in the cause and/or complication of events that occur in the commercial nuclear industry. In recent years, great gains have been made using Human Performance (HU) tools focused on targeting individual behaviors. However, the cost of improving HU is growing and resistance to add yet another HU tool certainly exists, particularly for those tools that increase the paperwork for operations. Improvements in HU that are the result of leveraging existing technology, such as hand-held mobile technologies, have the potential to reduce human error in controlling system configurations, safety tag-outs, and other verifications. Operator rounds, valve line-up verifications, containment closure verifications, safety & equipment protection, and system tagging can be supported by field-deployable wireless technologies. These devices can also support the availability of critical component data in the main control room and other locations. This research pilot project reviewing wireless hand-held technology is part of the Light Water Reactor Sustainability Program (LWRSP), a research and development (R&D) program sponsored by the U. S. Department of Energy (DOE). The project is being performed in close collaboration with industry R&D programs to provide the technical foundations for licensing, and managing the long-term, safe, and economical operation of current nuclear power plants. The LWRSP vision is to develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current nuclear reactor fleet.

  14. Sandia Energy - Human Reliability Assessment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Reliability Assessment Home Stationary Power Nuclear Fuel Cycle Nuclear Energy Safety Technologies Risk and Safety Assessment Human Reliability Assessment Human Reliability...

  15. A KNOWLEDGE BASE FOR JUSTIFIED INFORMATION SECURITY DECISION-MAKING

    E-Print Network [OSTI]

    Newcastle upon Tyne, University of

    A KNOWLEDGE BASE FOR JUSTIFIED INFORMATION SECURITY DECISION-MAKING Daria Stepanova, Simon E.K. dasha stepanova@list.ru, s.e.parkin@ncl.ac.uk, aad.vanmoorsel@ncl.ac.uk Keywords: Information security Information Security Officer (CISO) within an organisation to ensure that such information is adequately

  16. Decision Support Systems Marek J. Druzdzel and Roger R. Flynn

    E-Print Network [OSTI]

    Druzdzel, Marek J.

    . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 Summary 12 2 #12;Introduction Making decisions concerning complex systems (e.g., the management units; or the control of nuclear power plants) often strains our cognitive capabilities. Even though used as a synonym for DSS is knowledge-based systems, which refers to their attempt to formalize domain

  17. Fusion project decision delayed ITER -NUCLEAR FUSION PROJECT

    E-Print Network [OSTI]

    before a commercial reactor is built A decision on where to site the world's first big nuclear fusion-free energy - but the reactor will take 10 years to build. Pros and cons Member countries of the International research facility and a more moderate climate. Iter consortium European Union United States Russia China

  18. Delayed Nondeterminism in Continuous-Time Markov Decision Processes

    E-Print Network [OSTI]

    Ábrahám, Erika

    have to come home by 6 pm. · On your way, you stop at a red traffic light. · When it turns green, you you have to come home by 6 pm. · On your way, you stop at a red traffic light. · When it turns green Motivation Continuous-Time Markov Decision Processes: An Example Imagine you have to come home by 6 pm

  19. Compressive Video Classification for Decision Systems with Limited Resources

    E-Print Network [OSTI]

    Tsakalides, Panagiotis

    by the introduction of efficient computational models is video classification. With the advent of digital TVCompressive Video Classification for Decision Systems with Limited Resources George Tzagkarakis}@ics.forth.gr Abstract--In this paper, we address the problem of video classification from a set of compressed features

  20. Linear Discriminant Functions Linear Discriminant Functions and Decisions Surfaces

    E-Print Network [OSTI]

    Linear Discriminant Functions · Linear Discriminant Functions and Decisions Surfaces · Generalized Linear Discriminant Functions #12;Srihari: CSE 555 Introduction · Parametric Methods · Underlying pdfs are known · Training samples used to estimate pdf parameters · Linear Discriminant Functions · Forms

  1. Decision making performance in a combined heat and noise environment 

    E-Print Network [OSTI]

    Pope, Mattison Scott

    1993-01-01

    This thesis was performed in order to determine the ability to make correct decisions when presented with two stressors under four conditions: controlled (70'F and 65 dBA); heat (105'F and 65 dBA); noise (70'F and 83 dBA); ...

  2. Automatic Dependability Analysis for Supporting Design Decisions in UML

    E-Print Network [OSTI]

    Firenze, Università degli Studi di

    Automatic Dependability Analysis for Supporting Design Decisions in UML Andrea Bondavalli1, Istvan and analysis tools for the automatic validation of the system under design. We apply an automatic trans though a thorough system specification im- proves the quality of the design , it is not sufficient

  3. US-75 INTEGRATED CORRIDOR MANAGEMENT: DECISION SUPPORT SYSTEM

    E-Print Network [OSTI]

    US-75 INTEGRATED CORRIDOR MANAGEMENT: DECISION SUPPORT SYSTEM STAGE 3 The Integrated Corridor Management (ICM) Project fun- damentally changes how transportation agencies in the US-75 corridor reliability for commuters, and less pollution in local communities caused by idling vehicles in congested

  4. school of computing, informatics, and decision systems engineering

    E-Print Network [OSTI]

    with a growing focus on health informatics, urban services and global logistics is also attracting new students combined strengths in computing, modeling and decision making; new levels of energy and activity to an investment from the university, we were able to acquire 9,000 square feet of space in our building

  5. Decision process YES Is request for Directory or

    E-Print Network [OSTI]

    Weimer, Westley

    Decision process YES NO YES Is request for Directory or Restricted data? RESTRICTED Is requestor a University employee in your department or school? YES Do they have a legitimate EDUCATIONAL interest* in the data? YES DIRECTORY Will data be used for academic research by University faculty? Will data be used

  6. Demonstration of Decision Support Tools for Sustainable Development

    SciTech Connect (OSTI)

    Shropshire, David Earl; Jacobson, Jacob Jordan; Berrett, Sharon; Cobb, D. A.; Worhach, P.

    2000-11-01

    The Demonstration of Decision Support Tools for Sustainable Development project integrated the Bechtel/Nexant Industrial Materials Exchange Planner and the Idaho National Engineering and Environmental Laboratory System Dynamic models, demonstrating their capabilities on alternative fuel applications in the Greater Yellowstone-Teton Park system. The combined model, called the Dynamic Industrial Material Exchange, was used on selected test cases in the Greater Yellow Teton Parks region to evaluate economic, environmental, and social implications of alternative fuel applications, and identifying primary and secondary industries. The test cases included looking at compressed natural gas applications in Teton National Park and Jackson, Wyoming, and studying ethanol use in Yellowstone National Park and gateway cities in Montana. With further development, the system could be used to assist decision-makers (local government, planners, vehicle purchasers, and fuel suppliers) in selecting alternative fuels, vehicles, and developing AF infrastructures. The system could become a regional AF market assessment tool that could help decision-makers understand the behavior of the AF market and conditions in which the market would grow. Based on this high level market assessment, investors and decision-makers would become more knowledgeable of the AF market opportunity before developing detailed plans and preparing financial analysis.

  7. Building Decision Trees for the Multi-class Imbalance Problem

    E-Print Network [OSTI]

    Chawla, Nitesh V.

    Building Decision Trees for the Multi-class Imbalance Problem T. Ryan Hoens1 , Qi Qian2 , Nitesh V. In imbalanced datasets, the class of interest is generally a small fraction of the total instances, but misclassification of such instances is often expensive. While there is a significant body of research on the class

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    California at Davis, University of

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    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan scenario. #12;210 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS CHAPTER 9: TRANSITION SCENARIOS FOR THE U://creativecommons.org/licenses/by-nc-nd/3.0/>. For information on commercial licensing, contact copyright@ucdavis.edu. #12;209 SUSTAINABLE

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    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan://creativecommons.org/licenses/by-nc-nd/3.0/>. For information on commercial licensing, contact copyright@ucdavis.edu. #12;133 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS PART 1: INDIVIDUAL FUEL/VEHICLE PATHWAYS PART 2 Chapter 6: Comparing Greenhouse