National Library of Energy BETA

Sample records for human factors decision

  1. A decision support system prototype including human factors based on the TOGA meta-theory approach

    SciTech Connect (OSTI)

    Cappelli, M.; Memmi, F.; Gadomski, A. M.; Sepielli, M.

    2012-07-01

    The human contribution to the risk of operation of complex technological systems is often not negligible and sometimes tends to become significant, as shown by many reports on incidents and accidents occurred in the past inside Nuclear Power Plants (NPPs). An error of a human operator of a NPP can derive by both omission and commission. For instance, complex commission errors can also lead to significant catastrophic technological accidents, as for the case of the Three Mile Island accident. Typically, the problem is analyzed by focusing on the single event chain that has provoked the incident or accident. What is needed is a general framework able to include as many parameters as possible, i.e. both technological and human factors. Such a general model could allow to envisage an omission or commission error before it can happen or, alternatively, suggest preferred actions to do in order to take countermeasures to neutralize the effect of the error before it becomes critical. In this paper, a preliminary Decision Support System (DSS) based on the so-called (-) TOGA meta-theory approach is presented. The application of such a theory to the management of nuclear power plants has been presented in the previous ICAPP 2011. Here, a human factor simulator prototype is proposed in order to include the effect of human errors in the decision path. The DSS has been developed using a TRIGA research reactor as reference plant, and implemented using the LabVIEW programming environment and the Finite State Machine (FSM) model The proposed DSS shows how to apply the Universal Reasoning Paradigm (URP) and the Universal Management Paradigm (UMP) to a real plant context. The DSS receives inputs from instrumentation data and gives as output a suggested decision. It is obtained as the result of an internal elaborating process based on a performance function. The latter, describes the degree of satisfaction and efficiency, which are dependent on the level of responsibility related to

  2. Simulation of human decision making

    DOE Patents [OSTI]

    Forsythe, J. Chris; Speed, Ann E.; Jordan, Sabina E.; Xavier, Patrick G.

    2008-05-06

    A method for computer emulation of human decision making defines a plurality of concepts related to a domain and a plurality of situations related to the domain, where each situation is a combination of at least two of the concepts. Each concept and situation is represented in the computer as an oscillator output, and each situation and concept oscillator output is distinguishable from all other oscillator outputs. Information is input to the computer representative of detected concepts, and the computer compares the detected concepts with the stored situations to determine if a situation has occurred.

  3. Human Factors Engineering Analysis Tool

    Energy Science and Technology Software Center (OSTI)

    2002-03-04

    HFE-AT is a human factors engineering (HFE) software analysis tool (AT) for human-system interface design of process control systems, and is based primarily on NUREG-0700 guidance.

  4. Human factors in software development

    SciTech Connect (OSTI)

    Curtis, B.

    1986-01-01

    This book presents an overview of ergonomics/human factors in software development, recent research, and classic papers. Articles are drawn from the following areas of psychological research on programming: cognitive ergonomics, cognitive psychology, and psycholinguistics. Topics examined include: theoretical models of how programmers solve technical problems, the characteristics of programming languages, specification formats in behavioral research and psychological aspects of fault diagnosis.

  5. Accommodating complexity and human behaviors in decision analysis.

    SciTech Connect (OSTI)

    Backus, George A.; Siirola, John Daniel; Schoenwald, David Alan; Strip, David R.; Hirsch, Gary B.; Bastian, Mark S.; Braithwaite, Karl R.; Homer, Jack

    2007-11-01

    This is the final report for a LDRD effort to address human behavior in decision support systems. One sister LDRD effort reports the extension of this work to include actual human choices and additional simulation analyses. Another provides the background for this effort and the programmatic directions for future work. This specific effort considered the feasibility of five aspects of model development required for analysis viability. To avoid the use of classified information, healthcare decisions and the system embedding them became the illustrative example for assessment.

  6. Human factors in waste management

    SciTech Connect (OSTI)

    Moray, N.

    1994-10-01

    This article examines the role of human factors in radioactive waste management. Although few problems and ergonomics are special to radioactive waste management, some problems are unique especially with long term storage. The entire sociotechnical system must be looked at in order to see where improvement can take place because operator errors, as seen in Chernobyl and Bhopal, are ultimately the result of management errors.

  7. Post-event human decision errors: operator action tree/time reliability correlation

    SciTech Connect (OSTI)

    Hall, R E; Fragola, J; Wreathall, J

    1982-11-01

    This report documents an interim framework for the quantification of the probability of errors of decision on the part of nuclear power plant operators after the initiation of an accident. The framework can easily be incorporated into an event tree/fault tree analysis. The method presented consists of a structure called the operator action tree and a time reliability correlation which assumes the time available for making a decision to be the dominating factor in situations requiring cognitive human response. This limited approach decreases the magnitude and complexity of the decision modeling task. Specifically, in the past, some human performance models have attempted prediction by trying to emulate sequences of human actions, or by identifying and modeling the information processing approach applicable to the task. The model developed here is directed at describing the statistical performance of a representative group of hypothetical individuals responding to generalized situations.

  8. Human factors: a necessary tool for industry

    SciTech Connect (OSTI)

    Starcher, K.O.

    1984-03-09

    The need for human factors (ergonomics) input in the layout of a ferroelectric ceramics laboratory is presented as an example of the overall need for human factors professionals in industry. However, even in the absence of one trained in human factors, knowledge of a few principles in ergonomics will provide many possibilities for improving performance in the industrial environment.

  9. Human factors challenges for advanced process control

    SciTech Connect (OSTI)

    Stubler, W.F.; O`Hara, J..M.

    1996-08-01

    New human-system interface technologies provide opportunities for improving operator and plant performance. However, if these technologies are not properly implemented, they may introduce new challenges to performance and safety. This paper reports the results from a survey of human factors considerations that arise in the implementation of advanced human-system interface technologies in process control and other complex systems. General trends were identified for several areas based on a review of technical literature and a combination of interviews and site visits with process control organizations. Human factors considerations are discussed for two of these areas, automation and controls.

  10. Human factors in nuclear technology - a history

    SciTech Connect (OSTI)

    Jones, D.B. )

    1992-01-01

    Human factors, human factors engineering (HFE), or ergonomics did not receive much formal attention in nuclear technology prior to the Three Mile Island Unit 2 (TMI-2) incident. Three principal reasons exist for this lack of concern. First, emerging technologies show little concern with how people will use a new system. Making the new technology work is considered more important than the people who will use it. Second, the culture of the users of nuclear power did not recognize a need for human factors. Traditional utilities had well established and effective engineering designs for control of electric power generation, while medicine considered the use of nuclear isotopes another useful tool, not requiring special ergonomics. Finally, the nuclear industry owed much to Admiral Rickover. He was definitely opposed.

  11. HUMAN FACTORS GUIDANCE FOR CONTROL ROOM EVALUATION

    SciTech Connect (OSTI)

    OHARA,J.; BROWN,W.; STUBLER,W.; HIGGINS,J.; WACHTEL,J.; PERSENSKY,J.J.

    2000-07-30

    The Human-System Interface Design Review Guideline (NUREG-0700, Revision 1) was developed by the US Nuclear Regulatory Commission (NRC) to provide human factors guidance as a basis for the review of advanced human-system interface technologies. The guidance consists of three components: design review procedures, human factors engineering guidelines, and a software application to provide design review support called the ``Design Review Guideline.'' Since it was published in June 1996, Rev. 1 to NUREG-0700 has been used successfully by NRC staff, contractors and nuclear industry organizations, as well as by interested organizations outside the nuclear industry. The NRC has committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool in the face of emerging and rapidly changing technology. This paper addresses the current research to update of NUREG-0700 based on the substantial work that has taken place since the publication of Revision 1.

  12. Annotated bibliography of human factors applications literature

    SciTech Connect (OSTI)

    McCafferty, D.B.

    1984-09-30

    This bibliography was prepared as part of the Human Factors Technology Project, FY 1984, sponsored by the Office of Nuclear Safety, US Department of Energy. The project was conducted by Lawrence Livermore National Laboratory, with Essex Corporation as a subcontractor. The material presented here is a revision and expansion of the bibliographic material developed in FY 1982 as part of a previous Human Factors Technology Project. The previous bibliography was published September 30, 1982, as Attachment 1 to the FY 1982 Project Status Report.

  13. Human Factors Engineering Analysis Tool - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Factors Engineering Analysis Tool Software tool that enables easy and quick selection of applicable regulatory guidelines as starting point for human factors engineering ...

  14. A naturalistic decision making model for simulated human combatants

    SciTech Connect (OSTI)

    HUNTER,KEITH O.; HART,WILLIAM E.; FORSYTHE,JAMES C.

    2000-05-01

    The authors describe a naturalistic behavioral model for the simulation of small unit combat. This model, Klein's recognition-primed decision making (RPD) model, is driven by situational awareness rather than a rational process of selecting from a set of action options. They argue that simulated combatants modeled with RPD will have more flexible and realistic responses to a broad range of small-scale combat scenarios. Furthermore, they note that the predictability of a simulation using an RPD framework can be easily controlled to provide multiple evaluations of a given combat scenario. Finally, they discuss computational issues for building an RPD-based behavior engine for fully automated combatants in small conflict scenarios, which are being investigated within Sandia's Next Generation Site Security project.

  15. Human Factors and Data Fusion as Part of Control Systems Resilience

    SciTech Connect (OSTI)

    David I. Gertman

    2009-05-01

    Human performance and human decision making is counted upon as a crucial aspect of overall system resilience. Advanced control systems have the potential to provide operators and asset owners a wide range of data, deployed at different levels that can be used to support operator situation awareness. However, the sheer amount of data available can make it challenging for operators to assimilate information and respond appropriately. This paper reviews some of the challenges and issues associated with providing operators with actionable state awareness and argues for the over arching importance of integrating human factors as part of intelligent control systems design and implementation. It is argued that system resilience is improved by implementing human factors in operations and maintenance. This paper also introduces issues associated with resilience and data fusion and highlights areas in which human factors including field studies hold promise.

  16. Human Factors for Situation Assessment in Grid Operations

    SciTech Connect (OSTI)

    Guttromson, Ross T.; Schur, Anne; Greitzer, Frank L.; Paget, Mia L.

    2007-08-08

    Executive Summary Despite advances in technology, power system operators must assimilate overwhelming amounts of data to keep the grid operating. Analyses of recent blackouts have clearly demonstrated the need to enhance the operator’s situation awareness (SA). The long-term objective of this research is to integrate valuable technologies into the grid operator environment that support decision making under normal and abnormal operating conditions and remove non-technical barriers to enable the optimum use of these technologies by individuals working alone and as a team. More specifically, the research aims to identify methods and principles to increase SA of grid operators in the context of system conditions that are representative or common across many operating entities and develop operationally relevant experimental methods for studying technologies and operational practices which contribute to SA. With increasing complexity and interconnectivity of the grid, the scope and complexity of situation awareness have grown. New paradigms are needed to guide research and tool development aimed to enhance and improve operations. In reviewing related research, operating practices, systems, and tools, the present study established a taxonomy that provides a perspective on research and development surrounding power grid situation awareness and clarifies the field of human factors/SA for grid operations. Information sources that we used to identify critical factors underlying SA included interviews with experienced operational personnel, available historical summaries and transcripts of abnormal conditions and outages (e.g., the August 14, 2003 blackout), scientific literature, and operational policies/procedures and other documentation. Our analysis of August 2003 blackout transcripts and interviews adopted a different perspective than previous analyses of this material, and we complemented this analysis with additional interviews. Based on our analysis and a broad

  17. Human Factors Aspects of Operating Small Reactors

    SciTech Connect (OSTI)

    OHara, J.M.; Higgins, J.; Deem, R.; Xing, J.; DAgostino, A.

    2010-11-07

    The nuclear-power community has reached the stage of proposing advanced reactor designs to support power generation for decades to come. They are considering small modular reactors (SMRs) as one approach to meet these energy needs. While the power output of individual reactor modules is relatively small, they can be grouped to produce reactor sites with different outputs. Also, they can be designed to generate hydrogen, or to process heat. Many characteristics of SMRs are quite different from those of current plants, and so may require a concept of operations (ConOps) that also is different. The U.S. Nuclear Regulatory Commission (NRC) has begun examining the human factors engineering- (HFE) and ConOps- aspects of SMRs; if needed, they will formulate guidance to support SMR licensing reviews. We developed a ConOps model, consisting of the following dimensions: Plant mission; roles and responsibilities of all agents; staffing, qualifications, and training; management of normal operations; management of off-normal conditions and emergencies; and, management of maintenance and modifications. We are reviewing information on SMR design to obtain data about each of these dimensions, and have identified several preliminary issues. In addition, we are obtaining operations-related information from other types of multi-module systems, such as refineries, to identify lessons learned from their experience. Here, we describe the project's methodology and our preliminary findings.

  18. Human Reliability Analysis for Design: Using Reliability Methods for Human Factors Issues

    SciTech Connect (OSTI)

    Ronald Laurids Boring

    2010-11-01

    This paper reviews the application of human reliability analysis methods to human factors design issues. An application framework is sketched in which aspects of modeling typically found in human reliability analysis are used in a complementary fashion to the existing human factors phases of design and testing. The paper provides best achievable practices for design, testing, and modeling. Such best achievable practices may be used to evaluate and human system interface in the context of design safety certifications.

  19. Establishing a value chain for human factors in nuclear power plantcontrol room modernization

    SciTech Connect (OSTI)

    Joe, Jeffrey Clark; Thomas, Kenneth David; Boring, Ronald Laurids

    2015-07-01

    Commercial nuclear power plants in the United States (U.S.) have operated reliably and efficiently for decades. With the life extensions of plants now being planned for operation beyond their original operating licenses, there are opportunities to achieve even greater efficiencies, while maintaining high operational reliabilities, with strategic, risk- and economically-informed, upgrades to plant systems and infrastructure. The U.S. Department of Energy’s Light Water Reactor Sustainability (LWRS) program supports the commercial nuclear industry’s modernization efforts through research and development (R&D) activities across many areas to help establish the technical and economic bases for modernization activities. The Advanced Instrumentation, Information, and Control Systems Technologies pathway is one R&D focus area for the LWRS program, and has researchers at Idaho National Laboratory working with select utility partners to use human factors and instrumentation and controls R&D to help modernize the plant’s main control room. However, some in the nuclear industry have not been as enthusiastic about using human factors R&D to inform life extension decision making. Part of the reason for this may stem from uncertainty decision-makers have regarding how human factors fits into the value chain for nuclear power plant control room modernization. This paper reviews past work that has attempted to demonstrate the value of human factors, and then describes the value chain concept, how it applies to control room modernization, and then makes a case for how and why human factors is an essential link in the modernization value chain.

  20. Human factors issues in qualitative and quantitative safety analyses

    SciTech Connect (OSTI)

    Hahn, H.A.

    1993-10-01

    Humans are a critical and integral part of any operational system, be it a nuclear reactor, a facility for assembly or disassembling hazardous components, or a transportation network. In our concern over the safety of these systems, we often focus our attention on the hardware engineering components of such systems. However, experience has repeatedly demonstrated that it is often the human component that is the primary determinant of overall system safety. Both the nuclear reactor accidents at Chernobyl and Three Mile Island and shipping disasters such as the Exxon Valdez and the Herald of Free Enterprise accidents are attributable to human error. Concern over human contributions to system safety prompts us to include reviews of human factors issues in our safety analyses. In the conduct of Probabilistic Risk Assessments (PRAs), human factors issues are addressed using a quantitative method called Human Reliability Analysis (HRA). HRAs typically begin with the identification of potential sources of human error in accident sequences of interest. Human error analysis often employs plant and/or procedures walk-downs in which the analyst considers the ``goodness`` of procedures, training, and human-machine interfaces concerning their potential contribution to human error. Interviews with expert task performers may also be conducted. In the application of HRA, once candidate sources of human error have been identified, error probabilities are developed.

  1. The integration of Human Factors (HF) in the SAR process training course text

    SciTech Connect (OSTI)

    Ryan, T.G.

    1995-03-01

    This text provides the technical basis for a two-day course on human factors (HF), as applied to the Safety Analysis Report (SAR) process. The overall objective of this text and course is to: provide the participant with a working knowledge of human factors-related requirements, suggestions for doing a human safety analysis applying a graded approach, and an ability to demonstrate using the results of the human safety analysis, that human factors elements as defined by DOE (human factors engineering, procedures, training, oversight, staffing, qualifications), can support wherever necessary, nuclear safety commitments in the SAR. More specifically, the objectives of the text and course are: (1) To provide the SAR preparer with general guidelines for doing HE within the context of a graded approach for the SAR; (2) To sensitize DOE facility managers and staff, safety analysts and SAR preparers, independent reviewers, and DOE reviewers and regulators, to DOE Order 5480.23 requirements for HE in the SAR; (3) To provide managers, analysts, reviewers and regulators with a working knowledge of HE concepts and techniques within the context of a graded approach for the SAR, and (4) To provide SAR managers and DOE reviewers and regulators with general guidelines for monitoring and coordinating the work of preparers of HE inputs throughout the SAR process, and for making decisions regarding the safety relevance of HE inputs to the SAR. As a ready reference for implementing the human factors requirements of DOE Order 5480.22 and DOE Standard 3009-94, this course text and accompanying two-day course are intended for all persons who are involved in the SAR.

  2. UPDATING THE NRC GUIDANCE FOR HUMAN FACTORS ENGINEERING REVIEWS.

    SciTech Connect (OSTI)

    O HARA,J.M.; BROWN,W.S.; HIGGINS,J.C.; PERSENSKY,J.J.; LEWIS,P.M.; BONGARRA,J.

    2002-09-15

    The U.S. Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) aspects of nuclear plants. NUREG-0800 (Standard Review Plan), Chapter 18, ''Human Factors Engineering,'' is the principal NRC staff guidance document. Two main documents provide the review criteria to support the evaluations. The HFE Program Review Model (NUREG-0711) addresses the design process from planning to verification and validation to design implementation. The Human-System Interface Design Review Guidelines (NUREG-0700) provides the guidelines for the review of the HFE aspects of human-system interface technology, such as alarms, information systems, controls, and control room design. Since these documents were published in 1994 and 1996 respectively, they have been used by NRC staff, contractors, nuclear industry organizations, as well as by numerous organizations outside the nuclear industry. Using feedback from users and NRC research conducted in recent years, both documents have been revised and updated. This was done to ensure that they remain state-of-the-art evaluation tools for changing nuclear industry issues and emerging technologies. This paper describes the methodology used to revise and update the documents and summarizes the changes made to each and their current contents. Index Terms for this report are: Control system human factors, Ergonomics, Human factors, Nuclear power generation safety.

  3. Human factors engineering report for the cold vacuum drying facility

    SciTech Connect (OSTI)

    IMKER, F.W.

    1999-06-30

    The purpose of this report is to present the results and findings of the final Human Factors Engineering (HFE) technical analysis and evaluation of the Cold Vacuum Drying Facility (CVDF). Ergonomics issues are also addressed in this report, as appropriate. This report follows up and completes the preliminary work accomplished and reported by the Preliminary HFE Analysis report (SNF-2825, Spent Nuclear Fuel Project Cold Vacuum Drying Facility Human Factors Engineering Analysis: Results and Findings). This analysis avoids redundancy of effort except for ensuring that previously recommended HFE design changes have not affected other parts of the system. Changes in one part of the system may affect other parts of the system where those changes were not applied. The final HFE analysis and evaluation of the CVDF human-machine interactions (HMI) was expanded to include: the physical work environment, human-computer interface (HCI) including workstation and software, operator tasks, tools, maintainability, communications, staffing, training, and the overall ability of humans to accomplish their responsibilities, as appropriate. Key focal areas for this report are the process bay operations, process water conditioning (PWC) skid, tank room, and Central Control Room operations. These key areas contain the system safety-class components and are the foundation for the human factors design basis of the CVDF.

  4. Human factors evaluation of teletherapy: Literature review. Volume 5

    SciTech Connect (OSTI)

    Henriksen, K.; Kaye, R.D.; Jones, R.; Morisseau, D.S.; Serig, D.L.

    1995-07-01

    A series of human factors evaluations were undertaken to better understand the contributing factors to human error in the teletherapy environment. Teletherapy is a multidisciplinary methodology for treating cancerous tissue through selective exposure to an external beam of ionizing radiation. A team of human factors specialists, assisted by a panel of radiation oncologists, medical physicists, and radiation therapists, conducted site visits to radiation oncology departments at community hospitals, university centers, and free-standing clinics. A function and task analysis was performed initially to guide subsequent evaluations in the areas of workplace environment, system-user interfaces, procedures, training, and organizational practices. To further acquire an in-depth and up-to-date understanding of the practice of teletherapy in support of these evaluations, a systematic literature review was conducted. Factors that have a potential impact on the accuracy of treatment delivery were of primary concern. The present volume is the literature review. The volume starts with an overview of the multiphased nature of teletherapy, and then examines the requirement for precision, the increasing role of quality assurance, current conceptualizations of human error, and the role of system factors such as the workplace environment, user-system interfaces, procedures, training, and organizational practices.

  5. Human Factors Evaluation of Advanced Electric Power Grid Visualization Tools

    SciTech Connect (OSTI)

    Greitzer, Frank L.; Dauenhauer, Peter M.; Wierks, Tamara G.; Podmore, Robin

    2009-04-01

    This report describes initial human factors evaluation of four visualization tools (Graphical Contingency Analysis, Force Directed Graphs, Phasor State Estimator and Mode Meter/ Mode Shapes) developed by PNNL, and proposed test plans that may be implemented to evaluate their utility in scenario-based experiments.

  6. Simulation: Moving from Technology Challenge to Human Factors Success

    SciTech Connect (OSTI)

    Gould, Derek A.; Chalmers, Nicholas; Johnson, Sheena J.; Kilkenny, Caroline; White, Mark D.; Bech, Bo; Lonn, Lars; Bello, Fernando

    2012-06-15

    Recognition of the many limitations of traditional apprenticeship training is driving new approaches to learning medical procedural skills. Among simulation technologies and methods available today, computer-based systems are topical and bring the benefits of automated, repeatable, and reliable performance assessments. Human factors research is central to simulator model development that is relevant to real-world imaging-guided interventional tasks and to the credentialing programs in which it would be used.

  7. Human Factors Considerations in New Nuclear Power Plants: Detailed Analysis.

    SciTech Connect (OSTI)

    OHara,J.; Higgins, J.; Brown, W.; Fink, R.

    2008-02-14

    This Nuclear Regulatory Commission (NRC) sponsored study has identified human-performance issues in new and advanced nuclear power plants. To identify the issues, current industry developments and trends were evaluated in the areas of reactor technology, instrumentation and control technology, human-system integration technology, and human factors engineering (HFE) methods and tools. The issues were organized into seven high-level HFE topic areas: Role of Personnel and Automation, Staffing and Training, Normal Operations Management, Disturbance and Emergency Management, Maintenance and Change Management, Plant Design and Construction, and HFE Methods and Tools. The issues where then prioritized into four categories using a 'Phenomena Identification and Ranking Table' methodology based on evaluations provided by 14 independent subject matter experts. The subject matter experts were knowledgeable in a variety of disciplines. Vendors, utilities, research organizations and regulators all participated. Twenty issues were categorized into the top priority category. This Brookhaven National Laboratory (BNL) technical report provides the detailed methodology, issue analysis, and results. A summary of the results of this study can be found in NUREG/CR-6947. The research performed for this project has identified a large number of human-performance issues for new control stations and new nuclear power plant designs. The information gathered in this project can serve as input to the development of a long-term strategy and plan for addressing human performance in these areas through regulatory research. Addressing human-performance issues will provide the technical basis from which regulatory review guidance can be developed to meet these challenges. The availability of this review guidance will help set clear expectations for how the NRC staff will evaluate new designs, reduce regulatory uncertainty, and provide a well-defined path to new nuclear power plant licensing.

  8. The human factors of quality and QA in R D environments

    SciTech Connect (OSTI)

    Hill, S.G.

    1990-01-01

    Achieving quality is a human activity. It is therefore important to consider the human in the design, development and evaluation of work processes and environments in an effort to enhance human performance and minimize error. It is also important to allow for individual differences when considering human factors issues. Human Factors is the field of study which can provide information on integrating the human into the system. Human factors and quality are related for the customer of R D work, R D personnel who perform the work, and the quality professional who overviews the process of quality in the work. 18 refs., 1 fig.

  9. Applying Human Factors during the SIS Life Cycle

    SciTech Connect (OSTI)

    Avery, K.

    2010-05-05

    Safety Instrumented Systems (SIS) are widely used in U.S. Department of Energy's (DOE) nonreactor nuclear facilities for safety-critical applications. Although use of the SIS technology and computer-based digital controls, can improve performance and safety, it potentially introduces additional complexities, such as failure modes that are not readily detectable. Either automated actions or manual (operator) actions may be required to complete the safety instrumented function to place the process in a safe state or mitigate a hazard in response to an alarm or indication. DOE will issue a new standard, Application of Safety Instrumented Systems Used at DOE Nonreactor Nuclear Facilities, to provide guidance for the design, procurement, installation, testing, maintenance, operation, and quality assurance of SIS used in safety significant functions at DOE nonreactor nuclear facilities. The DOE standard focuses on utilizing the process industry consensus standard, American National Standards Institute/ International Society of Automation (ANSI/ISA) 84.00.01, Functional Safety: Safety Instrumented Systems for the Process Industry Sector, to support reliable SIS design throughout the DOE complex. SIS design must take into account human-machine interfaces and their limitations and follow good human factors engineering (HFE) practices. HFE encompasses many diverse areas (e.g., information display, user-system interaction, alarm management, operator response, control room design, and system maintainability), which affect all aspects of system development and modification. This paper presents how the HFE processes and principles apply throughout the SIS life cycle to support the design and use of SIS at DOE nonreactor nuclear facilities.

  10. A Human Factors Perspective on Alarm System Research and Development 2000 to 2010

    SciTech Connect (OSTI)

    Curt Braun; John Grimes; Eric Shaver; Ronald Boring

    2011-09-01

    By definition, alarms serve to notify human operators of out-of-parameter conditions that could threaten equipment, the environment, product quality and, of course, human life. Given the complexities of industrial systems, human machine interfaces, and the human operator, the understanding of how alarms and humans can best work together to prevent disaster is continually developing. This review examines advances in alarm research and development from 2000 to 2010 and includes the writings of trade professionals, engineering and human factors researchers, and standards organizations with the goal of documenting advances in alarms system design, research, and implementation.

  11. Analysis of human factors effects on the safety of transporting radioactive waste materials: Technical report

    SciTech Connect (OSTI)

    Abkowitz, M.D.; Abkowitz, S.B.; Lepofsky, M.

    1989-04-01

    This report examines the extent of human factors effects on the safety of transporting radioactive waste materials. It is seen principally as a scoping effort, to establish whether there is a need for DOE to undertake a more formal approach to studying human factors in radioactive waste transport, and if so, logical directions for that program to follow. Human factors effects are evaluated on driving and loading/transfer operations only. Particular emphasis is placed on the driving function, examining the relationship between human error and safety as it relates to the impairment of driver performance. Although multi-modal in focus, the widespread availability of data and previous literature on truck operations resulted in a primary study focus on the trucking mode from the standpoint of policy development. In addition to the analysis of human factors accident statistics, the report provides relevant background material on several policies that have been instituted or are under consideration, directed at improving human reliability in the transport sector. On the basis of reported findings, preliminary policy areas are identified. 71 refs., 26 figs., 5 tabs.

  12. HUMAN ERROR QUANTIFICATION USING PERFORMANCE SHAPING FACTORS IN THE SPAR-H METHOD

    SciTech Connect (OSTI)

    Harold S. Blackman; David I. Gertman; Ronald L. Boring

    2008-09-01

    This paper describes a cognitively based human reliability analysis (HRA) quantification technique for estimating the human error probabilities (HEPs) associated with operator and crew actions at nuclear power plants. The method described here, Standardized Plant Analysis Risk-Human Reliability Analysis (SPAR-H) method, was developed to aid in characterizing and quantifying human performance at nuclear power plants. The intent was to develop a defensible method that would consider all factors that may influence performance. In the SPAR-H approach, calculation of HEP rates is especially straightforward, starting with pre-defined nominal error rates for cognitive vs. action-oriented tasks, and incorporating performance shaping factor multipliers upon those nominal error rates.

  13. The Measure of Human Error: Direct and Indirect Performance Shaping Factors

    SciTech Connect (OSTI)

    Ronald L. Boring; Candice D. Griffith; Jeffrey C. Joe

    2007-08-01

    The goal of performance shaping factors (PSFs) is to provide measures to account for human performance. PSFs fall into two categories—direct and indirect measures of human performance. While some PSFs such as “time to complete a task” are directly measurable, other PSFs, such as “fitness for duty,” can only be measured indirectly through other measures and PSFs, such as through fatigue measures. This paper explores the role of direct and indirect measures in human reliability analysis (HRA) and the implications that measurement theory has on analyses and applications using PSFs. The paper concludes with suggestions for maximizing the reliability and validity of PSFs.

  14. Human Factors Engineering and Ergonomics Analysis for the Canister Storage Building (CSB) Results and Findings

    SciTech Connect (OSTI)

    GARVIN, L.J.

    1999-09-20

    The purpose for this supplemental report is to follow-up and update the information in SNF-3907, Human Factors Engineering (HFE) Analysis: Results and Findings. This supplemental report responds to applicable U.S. Department of Energy Safety Analysis Report review team comments and questions. This Human Factors Engineering and Ergonomics (HFE/Erg) analysis was conducted from April 1999 to July 1999; SNF-3907 was based on analyses accomplished in October 1998. The HFE/Erg findings presented in this report and SNF-3907, along with the results of HNF-3553, Spent Nuclear Fuel Project, Final Safety Analysis Report, Annex A, ''Canister Storage Building Final Safety Analysis Report,'' Chapter A3.0, ''Hazards and Accidents Analyses,'' provide the technical basis for preparing or updating HNF-3553. Annex A, Chaptex A13.0, ''Human Factors Engineering.'' The findings presented in this report allow the HNF-3553 Chapter 13.0, ''Human Factors,'' to respond fully to the HFE requirements established in DOE Order 5480.23, Nuclear Safety Analysis Reports.

  15. Human Factors Principles in Design of Computer-Mediated Visualization for Robot Missions

    SciTech Connect (OSTI)

    David I Gertman; David J Bruemmer

    2008-12-01

    With increased use of robots as a resource in missions supporting countermine, improvised explosive devices (IEDs), and chemical, biological, radiological nuclear and conventional explosives (CBRNE), fully understanding the best means by which to complement the human operator’s underlying perceptual and cognitive processes could not be more important. Consistent with control and display integration practices in many other high technology computer-supported applications, current robotic design practices rely highly upon static guidelines and design heuristics that reflect the expertise and experience of the individual designer. In order to use what we know about human factors (HF) to drive human robot interaction (HRI) design, this paper reviews underlying human perception and cognition principles and shows how they were applied to a threat detection domain.

  16. Applications of human factors engineering to LNG release prevention and control

    SciTech Connect (OSTI)

    Shikiar, R.; Rankin, W.L.; Rideout, T.B.

    1982-06-01

    The results of an investigation of human factors engineering and human reliability applications to LNG release prevention and control are reported. The report includes a discussion of possible human error contributions to previous LNG accidents and incidents, and a discussion of generic HF considerations for peakshaving plants. More specific recommendations for improving HF practices at peakshaving plants are offered based on visits to six facilities. The HF aspects of the recently promulgated DOT regulations are reviewed, and recommendations are made concerning how these regulations can be implemented utilizing standard HF practices. Finally, the integration of HF considerations into overall system safety is illustrated by a presentation of human error probabilities applicable to LNG operations and by an expanded fault tree analysis which explicitly recognizes man-machine interfaces.

  17. Human factors evaluation of remote afterloading brachytherapy. Volume 2, Function and task analysis

    SciTech Connect (OSTI)

    Callan, J.R.; Gwynne, J.W. III; Kelly, T.T.; Muckler, F.A.; Saunders, W.M.; Lepage, R.P.; Chin, E.; Schoenfeld, I.; Serig, D.I.

    1995-05-01

    A human factors project on the use of nuclear by-product material to treat cancer using remotely operated afterloaders was undertaken by the Nuclear Regulatory Commission. The purpose of the project was to identify factors that contribute to human error in the system for remote afterloading brachytherapy (RAB). This report documents the findings from the first phase of the project, which involved an extensive function and task analysis of RAB. This analysis identified the functions and tasks in RAB, made preliminary estimates of the likelihood of human error in each task, and determined the skills needed to perform each RAB task. The findings of the function and task analysis served as the foundation for the remainder of the project, which evaluated four major aspects of the RAB system linked to human error: human-system interfaces; procedures and practices; training and qualifications of RAB staff; and organizational practices and policies. At its completion, the project identified and prioritized areas for recommended NRC and industry attention based on all of the evaluations and analyses.

  18. Human factors design guidelines for maintainability of Department of Energy nuclear facilities

    SciTech Connect (OSTI)

    Bongarra, J.P. Jr.; VanCott, H.P.; Pain, R.F.; Peterson, L.R.; Wallace, R.I.

    1985-06-18

    Intent of these guidelines is to provide design and design review teams of DOE nuclear facilities with human factors principles to enhance the design and aid in the inspection of DOE nuclear facilities, systems, and equipment. These guidelines are concerned with design features of DOE nuclear facilities which can potentially affect preventive and corrective maintenance of systems within DOE nuclear facilities. Maintenance includes inspecting, checking, troubleshooting, adjusting, replacing, repairing, and servicing activities. Other factors which influence maintainability such as repair and maintenance suport facilities, maintenance information, and various aspects of the environment are also addressed.

  19. A Framework for Geometric Reasoning About Human Figures and Factors in Assembly Processes

    SciTech Connect (OSTI)

    Calton, Terri L.

    1999-07-20

    Automatic assembly sequencing and visualization tools are valuable in determining the best assembly sequences, but without Human Factors and Figure Models (HFFMs) it is difficult to evaluate or visualize human interaction. In industry, accelerating technological advances and shorter market windows have forced companies to turn to an agile manufacturing paradigm. This trend has promoted computerized automation of product design and manufacturing processes, such as automated assembly planning. However, all automated assembly planning software tools assume that the individual components fly into their assembled configuration and generate what appear to be perfectly valid operations, but in reality some operations cannot physically be carried out by a human. For example, the use of a ratchet may be reasoned feasible for an assembly operation; however, when a hand is placed on the tool the operation is no longer feasible, perhaps because of inaccessibility, insufficient strength or human interference with assembly components. Similarly, human figure modeling algorithms may indicate that assembly operations are not feasible and consequently force design modifications, however, if they had the capability to quickly generate alternative assembly sequences, they might have identified a feasible solution. To solve this problem, HFFMs must be integrated with automated assembly planning which allows engineers to quickly verify that assembly operations are possible and to see ways to make the designs even better. This paper presents a framework for integrating geometry-based assembly planning algorithms with commercially available human figure modeling software packages. Experimental results to selected applications along with lessons learned are presented.

  20. Human Factors/Ergonomics Handbook for the Design for Ease of Maintenance

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    7 2.0 DESIGN FOR MAINTAINABILITY This section contains human factors guidance for designing systems, subsystems, equipment and facilities so that maintenance is easy and cost effective. 2.1 Unitization, modularization, and standardization Unitization refers to separating equipment into physically and functionally distinct units to allow for easy removal and replacement. This type of equipment separation will permit division of maintenance responsibility, especially troubleshooting, among

  1. Spent nuclear fuel project, Cold Vacuum Drying Facility human factors engineering (HFE) analysis: Results and findings

    SciTech Connect (OSTI)

    Garvin, L.J.

    1998-07-17

    This report presents the background, methodology, and findings of a human factors engineering (HFE) analysis performed in May, 1998, of the Spent Nuclear Fuels (SNF) Project Cold Vacuum Drying Facility (CVDF), to support its Preliminary Safety Analysis Report (PSAR), in responding to the requirements of Department of Energy (DOE) Order 5480.23 (DOE 1992a) and drafted to DOE-STD-3009-94 format. This HFE analysis focused on general environment, physical and computer workstations, and handling devices involved in or directly supporting the technical operations of the facility. This report makes no attempt to interpret or evaluate the safety significance of the HFE analysis findings. The HFE findings presented in this report, along with the results of the CVDF PSAR Chapter 3, Hazards and Accident Analyses, provide the technical basis for preparing the CVDF PSAR Chapter 13, Human Factors Engineering, including interpretation and disposition of findings. The findings presented in this report allow the PSAR Chapter 13 to fully respond to HFE requirements established in DOE Order 5480.23. DOE 5480.23, Nuclear Safety Analysis Reports, Section 8b(3)(n) and Attachment 1, Section-M, require that HFE be analyzed in the PSAR for the adequacy of the current design and planned construction for internal and external communications, operational aids, instrumentation and controls, environmental factors such as heat, light, and noise and that an assessment of human performance under abnormal and emergency conditions be performed (DOE 1992a).

  2. Decision insight into stakeholder conflict for ERN.

    SciTech Connect (OSTI)

    Siirola, John; Tidwell, Vincent Carroll; Benz, Zachary O.; Stansbury, Melanie; Richards, Elizabeth H.; Turnley, Jessica Glicken; Warrender, Christina E.; Morrow, James Dan

    2012-02-01

    Participatory modeling has become an important tool in facilitating resource decision making and dispute resolution. Approaches to modeling that are commonly used in this context often do not adequately account for important human factors. Current techniques provide insights into how certain human activities and variables affect resource outcomes; however, they do not directly simulate the complex variables that shape how, why, and under what conditions different human agents behave in ways that affect resources and human interactions related to them. Current approaches also do not adequately reveal how the effects of individual decisions scale up to have systemic level effects in complex resource systems. This lack of integration prevents the development of more robust models to support decision making and dispute resolution processes. Development of integrated tools is further hampered by the fact that collection of primary data for decision-making modeling is costly and time consuming. This project seeks to develop a new approach to resource modeling that incorporates both technical and behavioral modeling techniques into a single decision-making architecture. The modeling platform is enhanced by use of traditional and advanced processes and tools for expedited data capture. Specific objectives of the project are: (1) Develop a proof of concept for a new technical approach to resource modeling that combines the computational techniques of system dynamics and agent based modeling, (2) Develop an iterative, participatory modeling process supported with traditional and advance data capture techniques that may be utilized to facilitate decision making, dispute resolution, and collaborative learning processes, and (3) Examine potential applications of this technology and process. The development of this decision support architecture included both the engineering of the technology and the development of a participatory method to build and apply the technology

  3. Comfort and human factors in office and residential settings. (Latest citations from the NTIS data base). Published Search

    SciTech Connect (OSTI)

    Not Available

    1992-04-01

    The bibliography contains citations concerning human factors engineering, anthropometry, and ergonomics as they relate to human comfort in the office and home. Human requirements, including ventilation, temperature control, and lighting, are considered. Research regarding environmental architecture, and engineering, safety, and convenience aspects are discussed. (Contains a minimum of 142 citations and includes a subject term index and title list.)

  4. Identification and Evaluation of Human Factors Issues Associated with Emerging Nuclear Plant Technology

    SciTech Connect (OSTI)

    O'Hara,J.M.; Higgins,J.; Brown, William S.

    2009-04-01

    This study has identified human performance research issues associated with the implementation of new technology in nuclear power plants (NPPs). To identify the research issues, current industry developments and trends were evaluated in the areas of reactor technology, instrumentation and control technology, human-system integration technology, and human factors engineering (HFE) methods and tools. The issues were prioritized into four categories based on evaluations provided by 14 independent subject matter experts representing vendors, utilities, research organizations and regulators. Twenty issues were categorized into the top priority category. The study also identifies the priority of each issue and the rationale for those in the top priority category. The top priority issues were then organized into research program areas of: New Concepts of Operation using Multi-agent Teams, Human-system Interface Design, Complexity Issues in Advanced Systems, Operating Experience of New and Modernized Plants, and HFE Methods and Tools. The results can serve as input to the development of a long-term strategy and plan for addressing human performance in these areas to support the safe operation of new NPPs.

  5. Psychophysiological and other factors affecting human performance in accident prevention and investigation. [Comparison of aviation with other industries

    SciTech Connect (OSTI)

    Klinestiver, L.R.

    1980-01-01

    Psychophysiological factors are not uncommon terms in the aviation incident/accident investigation sequence where human error is involved. It is highly suspect that the same psychophysiological factors may also exist in the industrial arena where operator personnel function; but, there is little evidence in literature indicating how management and subordinates cope with these factors to prevent or reduce accidents. It is apparent that human factors psychophysological training is quite evident in the aviation industry. However, while the industrial arena appears to analyze psychophysiological factors in accident investigations, there is little evidence that established training programs exist for supervisors and operator personnel.

  6. Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors

    SciTech Connect (OSTI)

    Erez, Neta; Glanz, Sarah; Raz, Yael; Avivi, Camilla; Barshack, Iris

    2013-08-02

    Highlights: •CAFs in human breast and ovarian tumors express pro-inflammatory factors. •Expression of pro-inflammatory factors correlates with tumor invasiveness. •Expression of pro-inflammatory factors is associated with NF-κb activation in CAFs. -- Abstract: Inflammation has been established in recent years as a hallmark of cancer. Cancer Associated Fibroblasts (CAFs) support tumorigenesis by stimulating angiogenesis, cancer cell proliferation and invasion. We previously demonstrated that CAFs also mediate tumor-enhancing inflammation in a mouse model of skin carcinoma. Breast and ovarian carcinomas are amongst the leading causes of cancer-related mortality in women and cancer-related inflammation is linked with both these tumor types. However, the role of CAFs in mediating inflammation in these malignancies remains obscure. Here we show that CAFs in human breast and ovarian tumors express high levels of the pro-inflammatory factors IL-6, COX-2 and CXCL1, previously identified to be part of a CAF pro-inflammatory gene signature. Moreover, we show that both pro-inflammatory signaling by CAFs and leukocyte infiltration of tumors are enhanced in invasive ductal carcinoma as compared with ductal carcinoma in situ. The pro-inflammatory genes expressed by CAFs are known NF-κB targets and we show that NF-κB is up-regulated in breast and ovarian CAFs. Our data imply that CAFs mediate tumor-promoting inflammation in human breast and ovarian tumors and thus may be an attractive target for stromal-directed therapeutics.

  7. Human factors evaluation of remote afterloading brachytherapy: Human error and critical tasks in remote afterloading brachytherapy and approaches for improved system performance. Volume 1

    SciTech Connect (OSTI)

    Callan, J.R.; Kelly, R.T.; Quinn, M.L.

    1995-05-01

    Remote Afterloading Brachytherapy (RAB) is a medical process used in the treatment of cancer. RAB uses a computer-controlled device to remotely insert and remove radioactive sources close to a target (or tumor) in the body. Some RAB problems affecting the radiation dose to the patient have been reported and attributed to human error. To determine the root cause of human error in the RAB system, a human factors team visited 23 RAB treatment sites in the US The team observed RAB treatment planning and delivery, interviewed RAB personnel, and performed walk-throughs, during which staff demonstrated the procedures and practices used in performing RAB tasks. Factors leading to human error in the RAB system were identified. The impact of those factors on the performance of RAB was then evaluated and prioritized in terms of safety significance. Finally, the project identified and evaluated alternative approaches for resolving the safety significant problems related to human error.

  8. NRC Reviewer Aid for Evaluating the Human Factors Engineering Aspects of Small Modular Reactors

    SciTech Connect (OSTI)

    OHara J. M.; Higgins, J.C.

    2012-01-13

    Small modular reactors (SMRs) are a promising approach to meeting future energy needs. Although the electrical output of an individual SMR is relatively small compared to that of typical commercial nuclear plants, they can be grouped to produce as much energy as a utility demands. Furthermore, SMRs can be used for other purposes, such as producing hydrogen and generating process heat. The design characteristics of many SMRs differ from those of current conventional plants and may require a distinct concept of operations (ConOps). The U.S. Nuclear Regulatory Commission (NRC) conducted research to examine the human factors engineering (HFE) and the operational aspects of SMRs. The research identified thirty potential human-performance issues that should be considered in the NRC's reviews of SMR designs and in future research activities. The purpose of this report is to support NRC HFE reviewers of SMR applications by identifying some of the questions that can be asked of applicants whose designs have characteristics identified in the issues. The questions for each issue were identified and organized based on the review elements and guidance contained in Chapter 18 of the Standard Review Plan (NUREG-0800), and the Human Factors Engineering Program Review Model (NUREG-0711).

  9. How Many Performance Shaping Factors are Necessary for Human Reliability Analysis?

    SciTech Connect (OSTI)

    Ronald L. Boring

    2010-06-01

    It has been argued that human reliability analysis (HRA) has expended considerable energy on creating detailed representations of human performance through an increasingly long list of performance shaping factors (PSFs). It is not clear, however, to what extent this refinement and expansion of PSFs has enhanced the quality of HRA. Indeed, there is considerable range in the number of PSFs provided by individual HRA methods, ranging from single factor models such as time-reliability curves, up to 50 or more PSFs in some current HRA models. The US Nuclear Regulatory Commission advocates 15 PSFs in its HRA Good Practices (NUREG-1792), while its SPAR-H method (NUREG/CR-6883) espouses the use of eight PSFs and its ATHEANA method (NUREG-1624) features an open-ended number of PSFs. The apparent differences in the optimal number of PSFs can be explained in terms of the diverse functions of PSFs in HRA. The purpose of this paper is to explore the role of PSFs across different stages of HRA, including identification of potential human errors, modeling of these errors into an overall probabilistic risk assessment, quantifying errors, and preventing errors.

  10. Human Factors Engineering (HFE) insights for advanced reactors based upon operating experience

    SciTech Connect (OSTI)

    Higgins, J.; Nasta, K.

    1997-01-01

    The NRC Human Factors Engineering Program Review Model (HFE PRM, NUREG-0711) was developed to support a design process review for advanced reactor design certification under 10CFR52. The HFE PRM defines ten fundamental elements of a human factors engineering program. An Operating Experience Review (OER) is one of these elements. The main purpose of an OER is to identify potential safety issues from operating plant experience and ensure that they are addressed in a new design. Broad-based experience reviews have typically been performed in the past by reactor designers. For the HFE PRM the intent is to have a more focussed OER that concentrates on HFE issues or experience that would be relevant to the human-system interface (HSI) design process for new advanced reactors. This document provides a detailed list of HFE-relevant operating experience pertinent to the HSI design process for advanced nuclear power plants. This document is intended to be used by NRC reviewers as part of the HFE PRM review process in determining the completeness of an OER performed by an applicant for advanced reactor design certification. 49 refs.

  11. Decision Analysis for EGS

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Decision Analysis for EGS Herbert H. Einstein Massachusetts Institute of Technology April 22, 2013 This presentation does not contain any proprietary confidential, or otherwise restricted information. Insert photo of your choice MIT 2 | US DOE Geothermal Office eere.energy.gov DECISION ANALYSIS FOR EGS Relevance/Impact of Research OBJECTIVES CHALLENGE - How to develop EGS projects that are affected by many unknown and variable factors. Uncertainties, particularly those related to the subsurface,

  12. Standardized Procedure Content And Data Structure Based On Human Factors Requirements For Computer-Based Procedures

    SciTech Connect (OSTI)

    Bly, Aaron; Oxstrand, Johanna; Le Blanc, Katya L

    2015-02-01

    Most activities that involve human interaction with systems in a nuclear power plant are guided by procedures. Traditionally, the use of procedures has been a paper-based process that supports safe operation of the nuclear power industry. However, the nuclear industry is constantly trying to find ways to decrease the human error rate, especially the human errors associated with procedure use. Advances in digital technology make computer-based procedures (CBPs) a valid option that provides further enhancement of safety by improving human performance related to procedure use. The transition from paper-based procedures (PBPs) to CBPs creates a need for a computer-based procedure system (CBPS). A CBPS needs to have the ability to perform logical operations in order to adjust to the inputs received from either users or real time data from plant status databases. Without the ability for logical operations the procedure is just an electronic copy of the paper-based procedure. In order to provide the CBPS with the information it needs to display the procedure steps to the user, special care is needed in the format used to deliver all data and instructions to create the steps. The procedure should be broken down into basic elements and formatted in a standard method for the CBPS. One way to build the underlying data architecture is to use an Extensible Markup Language (XML) schema, which utilizes basic elements to build each step in the smart procedure. The attributes of each step will determine the type of functionality that the system will generate for that step. The CBPS will provide the context for the step to deliver referential information, request a decision, or accept input from the user. The XML schema needs to provide all data necessary for the system to accurately perform each step without the need for the procedure writer to reprogram the CBPS. The research team at the Idaho National Laboratory has developed a prototype CBPS for field workers as well as the

  13. DEVELOPMENT OF HUMAN FACTORS ENGINEERING GUIDANCE FOR SAFETY EVALUATIONS OF ADVANCED REACTORS.

    SciTech Connect (OSTI)

    O'HARA, J.; PERSENSKY, J.; SZABO, A.

    2006-10-01

    Advanced reactors are expected to be based on a concept of operations that is different from what is currently used in today's reactors. Therefore, regulatory staff may need new tools, developed from the best available technical bases, to support licensing evaluations. The areas in which new review guidance may be needed and the efforts underway to address the needs will be discussed. Our preliminary results focus on some of the technical issues to be addressed in three areas for which new guidance may be developed: automation and control, operations under degraded conditions, and new human factors engineering methods and tools.

  14. Applying Human Factors Evaluation and Design Guidance to a Nuclear Power Plant Digital Control System

    SciTech Connect (OSTI)

    Thomas Ulrich; Ronald Boring; William Phoenix; Emily Dehority; Tim Whiting; Jonathan Morrell; Rhett Backstrom

    2012-08-01

    The United States (U.S.) nuclear industry, like similar process control industries, has moved toward upgrading its control rooms. The upgraded control rooms typically feature digital control system (DCS) displays embedded in the panels. These displays gather information from the system and represent that information on a single display surface. In this manner, the DCS combines many previously separate analog indicators and controls into a single digital display, whereby the operators can toggle between multiple windows to monitor and control different aspects of the plant. The design of the DCS depends on the function of the system it monitors, but revolves around presenting the information most germane to an operator at any point in time. DCSs require a carefully designed human system interface. This report centers on redesigning existing DCS displays for an example chemical volume control system (CVCS) at a U.S. nuclear power plant. The crucial nature of the CVCS, which controls coolant levels and boration in the primary system, requires a thorough human factors evaluation of its supporting DCS. The initial digital controls being developed for the DCSs tend to directly mimic the former analog controls. There are, however, unique operator interactions with a digital vs. analog interface, and the differences have not always been carefully factored in the translation of an analog interface to a replacement DCS. To ensure safety, efficiency, and usability of the emerging DCSs, a human factors usability evaluation was conducted on a CVCS DCS currently being used and refined at an existing U.S. nuclear power plant. Subject matter experts from process control engineering, software development, and human factors evaluated the DCS displays to document potential usability issues and propose design recommendations. The evaluation yielded 167 potential usability issues with the DCS. These issues should not be considered operator performance problems but rather opportunities

  15. Human factors in telemanipulation: Perspectives from the Oak Ridge National Laboratory experience

    SciTech Connect (OSTI)

    Draper, J.V.

    1994-01-01

    Personnel at the Robotics and Process Systems Division (RPSD) of the Oak Ridge National Laboratory (ORNL) have extensive experience designing, building, and operating teleoperators for a variety of settings, including space, battlefields, nuclear fuel reprocessing plants, and hazardous waste retrieval. In the course of the last decade and a half, the RPSD designed, built, and operated 4 telemanipulators (M-2, ASM, LTM, CESAR arm) and operated another half dozen (M-8, Model 50, TOS SM-229, RM-10, PaR 5000, BilArm 83A). During this period, human factors professionals have been closely integrated with RPSD design teams, investigating telemanipulator feedback and feed forward, designing cockpits and control rooms, training users and designers, and helping to develop performance specifications for telemanipulators. This paper presents a brief review of this and other work, with an aim towards providing perspectives on some of the human factors aspects of telemanipulation. The first section of the paper examines user tasks during supervisory control and discusses how telemanipulator responsiveness determines the appropriate control metaphor for continuous manual control. The second section provides an ecological perspective on telemanipulator feedback and feed-forward. The third section briefly describes the RPSD control room design approach and how design projects often serve as systems integrators.

  16. Human Factors Engineering Program Review Model (NUREG-0711)Revision 3: Update Methodology and Key Revisions

    SciTech Connect (OSTI)

    OHara J. M.; Higgins, J.; Fleger, S.

    2012-07-22

    The U.S. Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) programs of applicants for nuclear power plant construction permits, operating licenses, standard design certifications, and combined operating licenses. The purpose of these safety reviews is to help ensure that personnel performance and reliability are appropriately supported. Detailed design review procedures and guidance for the evaluations is provided in three key documents: the Standard Review Plan (NUREG-0800), the HFE Program Review Model (NUREG-0711), and the Human-System Interface Design Review Guidelines (NUREG-0700). These documents were last revised in 2007, 2004 and 2002, respectively. The NRC is committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool. To this end, the NRC is updating its guidance to stay current with recent research on human performance, advances in HFE methods and tools, and new technology being employed in plant and control room design. NUREG-0711 is the first document to be addressed. We present the methodology used to update NUREG-0711 and summarize the main changes made. Finally, we discuss the current status of the update program and the future plans.

  17. Updating Human Factors Engineering Guidelines for Conducting Safety Reviews of Nuclear Power Plants

    SciTech Connect (OSTI)

    O, J.M.; Higgins, J.; Stephen Fleger - NRC

    2011-09-19

    The U.S. Nuclear Regulatory Commission (NRC) reviews the human factors engineering (HFE) programs of applicants for nuclear power plant construction permits, operating licenses, standard design certifications, and combined operating licenses. The purpose of these safety reviews is to help ensure that personnel performance and reliability are appropriately supported. Detailed design review procedures and guidance for the evaluations is provided in three key documents: the Standard Review Plan (NUREG-0800), the HFE Program Review Model (NUREG-0711), and the Human-System Interface Design Review Guidelines (NUREG-0700). These documents were last revised in 2007, 2004 and 2002, respectively. The NRC is committed to the periodic update and improvement of the guidance to ensure that it remains a state-of-the-art design evaluation tool. To this end, the NRC is updating its guidance to stay current with recent research on human performance, advances in HFE methods and tools, and new technology being employed in plant and control room design. This paper describes the role of HFE guidelines in the safety review process and the content of the key HFE guidelines used. Then we will present the methodology used to develop HFE guidance and update these documents, and describe the current status of the update program.

  18. Human factors aspects of the major upgrade to the control systems at the LANL plutonium facility

    SciTech Connect (OSTI)

    Higgins, J.C.; Pope, N.

    1997-04-01

    The Plutonium Facility (TA-55) at Los Alamos National Laboratory (LANL) has been in operation for almost 20 years. The Operations Center of TA-55 is the nerve center of the facility where operators are on duty around the clock and monitor several thousand data points using the Facility Control System (FCS). The FCS monitors, displays, alarms, and provides some limited control of several systems, including: HVAC, fire detection and suppression, radiation detection, and electrical. The FCS was failing and needed to be replaced expeditiously. This paper will discuss the human factors aspects of the design, installation, and testing of the new FCS within the above noted constraints. Particular items to be discussed include the functional requirements definition, operating experience review, screen designs, test program, operator training, and phased activation of the new circuits in an operational facility.

  19. Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors

    SciTech Connect (OSTI)

    Yakubov, Eduard; Rechavi, Gidi; Rozenblatt, Shmuel; Givol, David

    2010-03-26

    Reprogramming of differentiated cells into induced pluripotent cells (iPS) was accomplished in 2006 by expressing four, or less, embryonic stem cell (ESC)-specific transcription factors. Due to the possible danger of DNA damage and the potential tumorigenicity associated with such DNA damage, attempts were made to minimize DNA integration by the vectors involved in this process without complete success. Here we present a method of using RNA transfection as a tool for reprogramming human fibroblasts to iPS. We used RNA synthesized in vitro from cDNA of the same reprogramming four transcription factors. After transfection of the RNA, we show intracellular expression and nuclear localization of the respective proteins in at least 70% of the cells. We used five consecutive transfections to support continuous protein expression resulting in the formation of iPS colonies that express alkaline phosphatase and several ESC markers and that can be expanded. This method completely avoids DNA integration and may be developed to replace the use of DNA vectors in the formation of iPS.

  20. Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution

    SciTech Connect (OSTI)

    Chen, Liqing Wang, Yujun; Wells, David; Toh, Diana; Harold, Hunt; Zhou, Jing; DiGiammarino, Enrico; Meehan, Edward J.

    2006-09-01

    The crystal structure of the SH3 domain of human osteoclast-stimulating factor has been determined and refined to the ultrahigh resolution of 1.07 Ĺ. The structure at atomic resolution provides an accurate framework for structure-based design of its inhibitors. Osteoclast-stimulating factor (OSF) is an intracellular signaling protein, produced by osteoclasts themselves, that enhances osteoclast formation and bone resorption. It is thought to act via an Src-related signaling pathway and contains SH3 and ankyrin-repeat domains which are involved in protein–protein interactions. As part of a structure-based anti-bone-loss drug-design program, the atomic resolution X-ray structure of the recombinant human OSF SH3 domain (hOSF-SH3) has been determined. The domain, residues 12–72, yielded crystals that diffracted to the ultrahigh resolution of 1.07 Ĺ. The overall structure shows a characteristic SH3 fold consisting of two perpendicular ?-sheets that form a ?-barrel. Structure-based sequence alignment reveals that the putative proline-rich peptide-binding site of hOSF-SH3 consists of (i) residues that are highly conserved in the SH3-domain family, including residues Tyr21, Phe23, Trp49, Pro62, Asn64 and Tyr65, and (ii) residues that are less conserved and/or even specific to hOSF, including Thr22, Arg26, Thr27, Glu30, Asp46, Thr47, Asn48 and Leu60, which might be key to designing specific inhibitors for hOSF to fight osteoporosis and related bone-loss diseases. There are a total of 13 well defined water molecules forming hydrogen bonds with the above residues in and around the peptide-binding pocket. Some of those water molecules might be important for drug-design approaches. The hOSF-SH3 structure at atomic resolution provides an accurate framework for structure-based design of its inhibitors.

  1. Human-factors-based implementation of the remote characterization system high-level control station

    SciTech Connect (OSTI)

    Noakes, M.W.; Richardson, B.S.; Rowe, J.C.; Draper, J.V. ); Sandness, G.R. )

    1993-01-01

    The detection and characterization of buried objects and materials is an important first step in the restoration of the numerous US Department of Energy (DOE) and US Department of Defense waste disposal sites. DOE, through its Environmental Restoration and Waste Management Robotics and Technology Development Program, has developed the Remote Characterization System (RCS) to address the needs of remote subsurfacecharacterization. The RCS consists of a low-metal-content (low-metallic-signature) remotely piloted vehicle, a high-level control station (HLCS) where operators can remotely control the vehicle and analyze real-time data from sensors, and an array of sensors that can be chosen to meet the survey task at hand. Communication between the vehicle and the base station is handled by a radio link. Site mapping is made possible through the use of geopositioning satellite data. The primary mode of vehicle operation is teleoperation, but provision has been made for semiautonomous or supervisory control that allows for automated sitesurvey on simple sites. Data analysis and display is supported for both real-time observation and postprocessing of data. The particular emphasis of this paper documents the human-factors-based design influences on the HLCS and describes the design in detail.

  2. Human performance modeling for system of systems analytics: combat performance-shaping factors.

    SciTech Connect (OSTI)

    Lawton, Craig R.; Miller, Dwight Peter

    2006-01-01

    The US military has identified Human Performance Modeling (HPM) as a significant requirement and challenge of future systems modeling and analysis initiatives. To support this goal, Sandia National Laboratories (SNL) has undertaken a program of HPM as an integral augmentation to its system-of-system (SoS) analytics capabilities. The previous effort, reported in SAND2005-6569, evaluated the effects of soldier cognitive fatigue on SoS performance. The current effort began with a very broad survey of any performance-shaping factors (PSFs) that also might affect soldiers performance in combat situations. The work included consideration of three different approaches to cognition modeling and how appropriate they would be for application to SoS analytics. This bulk of this report categorizes 47 PSFs into three groups (internal, external, and task-related) and provides brief descriptions of how each affects combat performance, according to the literature. The PSFs were then assembled into a matrix with 22 representative military tasks and assigned one of four levels of estimated negative impact on task performance, based on the literature. Blank versions of the matrix were then sent to two ex-military subject-matter experts to be filled out based on their personal experiences. Data analysis was performed to identify the consensus most influential PSFs. Results indicate that combat-related injury, cognitive fatigue, inadequate training, physical fatigue, thirst, stress, poor perceptual processing, and presence of chemical agents are among the PSFs with the most negative impact on combat performance.

  3. Human Factors/Ergonomics Handbook for the Design for the Ease...

    Broader source: Energy.gov (indexed) [DOE]

    ... based on ergonomic optimization for the human hand and strength envelopes, and the task ... evaluated in terms of safety and human strength. 4.9.1.2 Stair, ladder and ramp layout. ...

  4. Waste-to-energy: Decision making and the decisions made

    SciTech Connect (OSTI)

    Schexnayder, S.M. ); Wolfe, A.K. )

    1993-01-01

    During the early 1980s, it was projected that waste-to-energy (WTE) facilities would manage as much as half of all municipal solid waste by the turn of the century. However, during the latter part of the 1980s, the cancellation rate for WTE facilities grew to the point that the portion of the waste stream WTE will handle in the long-term future is less certain. This study, conducted as part of a larger study, identifies factors that influence municipalities, decisions regarding WTE. This study takes a broad perspective about decision-making within communities, emphasizing the context within which decisions were made and the decision-making process. It does not seek to judge the correctness of the decisions.

  5. Waste-to-energy: Decision making and the decisions made

    SciTech Connect (OSTI)

    Schexnayder, S.M.; Wolfe, A.K.

    1993-05-01

    During the early 1980s, it was projected that waste-to-energy (WTE) facilities would manage as much as half of all municipal solid waste by the turn of the century. However, during the latter part of the 1980s, the cancellation rate for WTE facilities grew to the point that the portion of the waste stream WTE will handle in the long-term future is less certain. This study, conducted as part of a larger study, identifies factors that influence municipalities, decisions regarding WTE. This study takes a broad perspective about decision-making within communities, emphasizing the context within which decisions were made and the decision-making process. It does not seek to judge the correctness of the decisions.

  6. Human perceptual deficits as factors in computer interface test and evaluation

    SciTech Connect (OSTI)

    Bowser, S.E.

    1992-06-01

    Issues related to testing and evaluating human computer interfaces are usually based on the machine rather than on the human portion of the computer interface. Perceptual characteristics of the expected user are rarely investigated, and interface designers ignore known population perceptual limitations. For these reasons, environmental impacts on the equipment will more likely be defined than will user perceptual characteristics. The investigation of user population characteristics is most often directed toward intellectual abilities and anthropometry. This problem is compounded by the fact that some deficits capabilities tend to be found in higher-than-overall population distribution in some user groups. The test and evaluation community can address the issue from two primary aspects. First, assessing user characteristics should be extended to include tests of perceptual capability. Secondly, interface designs should use multimode information coding.

  7. Automated work packages architecture: An initial set of human factors and instrumentation and controls requirements

    SciTech Connect (OSTI)

    Agarwal, Vivek; Oxstrand, Johanna H.; Le Blanc, Katya L.

    2014-09-01

    The work management process in current fleets of national nuclear power plants is so highly dependent on large technical staffs and quality of work instruction, i.e., paper-based, that this puts nuclear energy at somewhat of a long-term economic disadvantage and increase the possibility of human errors. Technologies like mobile portable devices and computer-based procedures can play a key role in improving the plant work management process, thereby increasing productivity and decreasing cost. Automated work packages are a fundamentally an enabling technology for improving worker productivity and human performance in nuclear power plants work activities because virtually every plant work activity is accomplished using some form of a work package. As part of this year’s research effort, automated work packages architecture is identified and an initial set of requirements identified, that are essential and necessary for implementation of automated work packages in nuclear power plants.

  8. Human factors design, verification, and validation for two types of control room upgrades at a nuclear power plant

    SciTech Connect (OSTI)

    Boring, Laurids Ronald

    2014-10-01

    This paper describes the NUREG-0711 based human factors engineering (HFE) phases and associated elements required to support design, verification and validation (V&V), and implementation of a new plant process computer (PPC) and turbine control system (TCS) at a representative nuclear power plant. This paper reviews ways to take a human-system interface (HSI) specification and use it when migrating legacy PPC displays or designing displays with new functionality. These displays undergo iterative usability testing during the design phase and then undergo an integrated system validation (ISV) in a full scope control room training simulator. Following the successful demonstration of operator performance with the systems during the ISV, the new system is implemented at the plant, first in the training simulator and then in the main control room.

  9. Human factors in E&P facility design, a participatory approach

    SciTech Connect (OSTI)

    Dekker, G.F.; Bergen, E.A. van den

    1996-11-01

    To ensure that ergonomics are taken into account in the conceptual design phases of engineering projects, NAM has introduced the {open_quote}Ergonomics in design{close_quote} workshop. This paper describes the general format, timing and techniques used in these workshops. An example of a case study is presented together with a cost benefit analysis. Finally, a concluding summary of the workshop success factors is given together with the areas for further improvement.

  10. Human Factors and Technical Considerations for a Computerized Operator Support System Prototype

    SciTech Connect (OSTI)

    Ulrich, Thomas Anthony; Lew, Roger Thomas; Medema, Heather Dawne; Boring, Ronald Laurids; Thomas, Kenneth David

    2015-09-01

    A prototype computerized operator support system (COSS) has been developed in order to demonstrate the concept and provide a test bed for further research. The prototype is based on four underlying elements consisting of a digital alarm system, computer-based procedures, PI&D system representations, and a recommender module for mitigation actions. At this point, the prototype simulates an interface to a sensor validation module and a fault diagnosis module. These two modules will be fully integrated in the next version of the prototype. The initial version of the prototype is now operational at the Idaho National Laboratory using the U.S. Department of Energy’s Light Water Reactor Sustainability (LWRS) Human Systems Simulation Laboratory (HSSL). The HSSL is a full-scope, full-scale glass top simulator capable of simulating existing and future nuclear power plant main control rooms. The COSS is interfaced to the Generic Pressurized Water Reactor (gPWR) simulator with industry-typical control board layouts. The glass top panels display realistic images of the control boards that can be operated by touch gestures. A section of the simulated control board was dedicated to the COSS human-system interface (HSI), which resulted in a seamless integration of the COSS into the normal control room environment. A COSS demonstration scenario has been developed for the prototype involving the Chemical & Volume Control System (CVCS) of the PWR simulator. It involves a primary coolant leak outside of containment that would require tripping the reactor if not mitigated in a very short timeframe. The COSS prototype presents a series of operator screens that provide the needed information and soft controls to successfully mitigate the event.

  11. Human mitochondrial transcription factor A functions in both nuclei and mitochondria and regulates cancer cell growth

    SciTech Connect (OSTI)

    Han, Bin; Izumi, Hiroto; Yasuniwa, Yoshihiro; Akiyama, Masaki; Yamaguchi, Takahiro; Fujimoto, Naohiro; Matsumoto, Tetsuro; Wu, Bin; Tanimoto, Akihide; Sasaguri, Yasuyuki; Kohno, Kimitoshi

    2011-04-29

    Highlights: {yields} Mitochondrial transcription factor A (mtTFA) localizes in nuclei and binds tightly to the nuclear chromatin. {yields} mtTFA contains two putative nuclear localization signals (NLS) in the HMG-boxes. {yields} Overexpression of mtTFA enhances the growth of cancer cells, whereas downregulation of mtTFA inhibits their growth by regulating mtTFA target genes, such as baculoviral IAP repeat-containing 5 (BIRC5; also known as survivin). {yields} Knockdown of mtTFA expression induces p21-dependent G1 cell cycle arrest. -- Abstract: Mitochondrial transcription factor A (mtTFA) is one of the high mobility group protein family and is required for both transcription from and maintenance of mitochondrial genomes. However, the roles of mtTFA have not been extensively studied in cancer cells. Here, we firstly reported the nuclear localization of mtTFA. The proportion of nuclear-localized mtTFA varied among different cancer cells. Some mtTFA binds tightly to the nuclear chromatin. DNA microarray and chromatin immunoprecipitation assays showed that mtTFA can regulate the expression of nuclear genes. Overexpression of mtTFA enhanced the growth of cancer cell lines, whereas downregulation of mtTFA inhibited their growth by regulating mtTFA target genes, such as baculoviral IAP repeat-containing 5 (BIRC5; also known as survivin). Knockdown of mtTFA expression induced p21-dependent G1 cell cycle arrest. These results imply that mtTFA functions in both nuclei and mitochondria to promote cell growth.

  12. Well Placement Decision Process

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Well Placement Decision Process Well Placement Decision Process Determining where to place a well is a multi-step process. August 1, 2013 Investigation process for determining where to place a sentinel well Investigation process for determining where

  13. Effects of Adenovirus-Mediated Delivery of the Human Hepatocyte Growth Factor Gene in Experimental Radiation-Induced Heart Disease

    SciTech Connect (OSTI)

    Hu Shunying; Chen Yundai; Li Libing; Chen Jinlong; Wu Bin; Zhou, Xiao; Zhi Guang; Li Qingfang; Wang Rongliang; Duan Haifeng; Guo Zikuan; Yang Yuefeng; Xiao Fengjun; Wang Hua; Wang Lisheng

    2009-12-01

    Purpose: Irradiation to the heart may lead to late cardiovascular complications. The purpose of this study was to investigate whether adenovirus-mediated delivery of the human hepatocyte growth factor gene could reduce post-irradiation damage of the rat heart and improve heart function. Methods and Materials: Twenty rats received single-dose irradiation of 20 Gy gamma ray locally to the heart and were randomized into two groups. Two weeks after irradiation, these two groups of rats received Ad-HGF or mock adenovirus vector intramyocardial injection, respectively. Another 10 rats served as sham-irradiated controls. At post-irradiation Day 120, myocardial perfusion was tested by myocardial contrast echocardiography with contrast agent injected intravenously. At post-irradiation Day 180, cardiac function was assessed using the Langendorff technique with an isolated working heart model, after which heart samples were collected for histological evaluation. Results: Myocardial blood flow was significantly improved in HGF-treated animals as measured by myocardial contrast echocardiography at post-irradiation Day 120 . At post-irradiation Day 180, cardiac function was significantly improved in the HGF group compared with mock vector group, as measured by left ventricular peak systolic pressure (58.80 +- 9.01 vs. 41.94 +- 6.65 mm Hg, p < 0.05), the maximum dP/dt (5634 +- 1303 vs. 1667 +- 304 mm Hg/s, p < 0.01), and the minimum dP/dt (3477 +- 1084 vs. 1566 +- 499 mm Hg/s, p < 0.05). Picrosirius red staining analysis also revealed a significant reduction of fibrosis in the HGF group. Conclusion: Based on the study findings, hepatocyte growth factor gene transfer can attenuate radiation-induced cardiac injury and can preserve cardiac function.

  14. MicroRNA-26a modulates transforming growth factor beta-1-induced proliferation in human fetal lung fibroblasts

    SciTech Connect (OSTI)

    Li, Xiaoou; Liu, Lian; Shen, Yongchun; Wang, Tao; Chen, Lei; Xu, Dan; Wen, Fuqiang

    2014-11-28

    Highlights: • Endogenous miR-26a inhibits TGF-beta 1 induced proliferation of lung fibroblasts. • miR-26a induces G1 arrest through directly targeting 3′-UTR of CCND2. • TGF indispensable receptor, TGF-beta R I, is regulated by miR-26a. • miR-26a acts through inhibiting TGF-beta 2 feedback loop to reduce TGF-beta 1. • Collagen type I and connective tissue growth factor are suppressed by miR-26a. - Abstract: MicroRNA-26a is a newly discovered microRNA that has a strong anti-tumorigenic capacity and is capable of suppressing cell proliferation and activating tumor-specific apoptosis. However, whether miR-26a can inhibit the over-growth of lung fibroblasts remains unclear. The relationship between miR-26a and lung fibrosis was explored in the current study. We first investigated the effect of miR-26a on the proliferative activity of human lung fibroblasts with or without TGF-beta1 treatment. We found that the inhibition of endogenous miR-26a promoted proliferation and restoration of mature miR-26a inhibited the proliferation of human lung fibroblasts. We also examined that miR-26a can block the G1/S phase transition via directly targeting 3′-UTR of CCND2, degrading mRNA and decreasing protein expression of Cyclin D2. Furthermore, we showed that miR-26a mediated a TGF-beta 2-TGF-beta 1 feedback loop and inhibited TGF-beta R I activation. In addition, the overexpression of miR-26a also significantly suppressed the TGF-beta 1-interacting-CTGF–collagen fibrotic pathway. In summary, our studies indicated an essential role of miR-26a in the anti-fibrotic mechanism in TGF-beta1-induced proliferation in human lung fibroblasts, by directly targeting Cyclin D2, regulating TGF-beta R I as well as TGF-beta 2, and suggested the therapeutic potential of miR-26a in ameliorating lung fibrosis.

  15. Development of Improved Graphical Displays for an Advanced Outage Control Center, Employing Human Factors Principles for Outage Schedule Management

    SciTech Connect (OSTI)

    St Germain, Shawn Walter; Farris, Ronald Keith; Thomas, Kenneth David

    2015-09-01

    The long-term viability of existing nuclear power plants in the United States (U.S.) is dependent upon a number of factors, including maintaining high capacity factors, maintaining nuclear safety, and reducing operating costs, particularly those associated with refueling outages. Refueling outages typically take 20-30 days, and for existing light water NPPs in the U.S., the reactor cannot be in operation during the outage. Furthermore, given that many NPPs generate between $1-1.5 million/day in revenue when in operation, there is considerable interest in shortening the length of refueling outages. Yet refueling outages are highly complex operations, involving multiple concurrent and dependent activities that are somewhat challenging to coordinate; therefore, finding ways to improve refueling outage performance, while maintaining nuclear safety has proven to be difficult. The Advanced Outage Control Center (AOCC) project is a research and development (R&D) demonstration activity under the LWRS Program. LWRS is an R&D program that works closely with industry R&D programs to establish technical foundations for the licensing and managing of long-term, safe, and economical operation of current fleet of NPPs. As such, the LWRS Advanced Outage Control Center project has the goal of improving the management of commercial NPP refueling outages. To accomplish this goal, INL is developing an advanced outage control center (OCC) that is specifically designed to maximize the usefulness of communication and collaboration technologies for outage coordination and problem resolution activities. The overall focus is on developing an AOCC with the following capabilities that enables plant and OCC staff to; Collaborate in real-time to address emergent issues; Effectively communicate outage status to all workers involved in the outage; Effectively communicate discovered conditions in the field to the OCC; Provide real-time work status; Provide automatic pending support notifications

  16. Feasibility of developing a portable driver performance data acquisition system for human factors research: Design specifications. Volume 3

    SciTech Connect (OSTI)

    Carter, R.J.; Barickman, F.S.

    1998-01-01

    A two-phase, multi-year research program entitled ``development of a portable driver performance data acquisition system for human factors research was recently completed. The primary objective of the project was to develop a portable data acquisition system for crash avoidance research (DASCAR) that will allow driver performance data to be collected using a large variety of vehicle types and that would be capable of being installed on a given vehicle type within a relatively short-time frame. During Phase 1 a feasibility study for designing and fabricating DASCAR was conducted. In phase 2 of the research DASCAR was actually developed and validated. This technical memorandum documents the results from the feasibility study. It is subdivided into three volumes. Volume one addresses the last five items in the phase 1 research and the first issue in the second phase of the project. Volume 2 presents the related appendices. Volume three (this report) displays the design specifications developed for DASCAR during the ``develop design requirements and specifications for a portable driver performance data acquisition system`` task. Design specifications were assembled for each DASCAR element. The specifications were prepared in sufficient detail to allow a third party to use them to design, develop, procure, and subsequently construct the data acquisition system. This report also covers the background to the program.

  17. Decision Summaries | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Information Center » Decision Summaries Decision Summaries July 29, 2016 Summary of Decisions - July 25, 2016 - July 29, 2016 Decisions were issued on: - Personnel Security (10 CFR Part 710) - Freedom of Information Act Appeal July 22, 2016 Summary of Decisions - July 18, 2016 - July 22, 2016 Decisions were issued on: - Personnel Security (10 CFR Part 710) - Freedom of Information Act Appeal July 15, 2016 Summary of Decisions - July 11, 2016 - July 15, 2016 Decisions were issued on: - Personnel

  18. First Evaluation of the Biologic Effectiveness Factors of Boron Neutron Capture Therapy (BNCT) in a Human Colon Carcinoma Cell Line

    SciTech Connect (OSTI)

    Dagrosa, Maria Alejandra; Crivello, Martin; Perona, Marina; Thorp, Silvia; Santa Cruz, Gustavo Alberto; Pozzi, Emiliano; Casal, Mariana; Thomasz, Lisa; Cabrini, Romulo; Kahl, Steven; Juvenal, Guillermo Juan; Pisarev, Mario Alberto

    2011-01-01

    Purpose: DNA lesions produced by boron neutron capture therapy (BNCT) and those produced by gamma radiation in a colon carcinoma cell line were analyzed. We have also derived the relative biologic effectiveness factor (RBE) of the neutron beam of the RA-3- Argentine nuclear reactor, and the compound biologic effectiveness (CBE) values for p-boronophenylalanine ({sup 10}BPA) and for 2,4-bis ({alpha},{beta}-dihydroxyethyl)-deutero-porphyrin IX ({sup 10}BOPP). Methods and Materials: Exponentially growing human colon carcinoma cells (ARO81-1) were distributed into the following groups: (1) BPA (10 ppm {sup 10}B) + neutrons, (2) BOPP (10 ppm {sup 10}B) + neutrons, (3) neutrons alone, and (4) gamma rays ({sup 60}Co source at 1 Gy/min dose-rate). Different irradiation times were used to obtain total absorbed doses between 0.3 and 5 Gy ({+-}10%) (thermal neutrons flux = 7.5 10{sup 9} n/cm{sup 2} sec). Results: The frequency of micronucleated binucleated cells and the number of micronuclei per micronucleated binucleated cells showed a dose-dependent increase until approximately 2 Gy. The response to gamma rays was significantly lower than the response to the other treatments (p < 0.05). The irradiations with neutrons alone and neutrons + BOPP showed curves that did not differ significantly from, and showed less DNA damage than, irradiation with neutrons + BPA. A decrease in the surviving fraction measured by 3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolium bromide (MTT) assay as a function of the absorbed dose was observed for all the treatments. The RBE and CBE factors calculated from cytokinesis block micronucleus (CBMN) and MTT assays were, respectively, the following: beam RBE: 4.4 {+-} 1.1 and 2.4 {+-} 0.6; CBE for BOPP: 8.0 {+-} 2.2 and 2.0 {+-} 1; CBE for BPA: 19.6 {+-} 3.7 and 3.5 {+-} 1.3. Conclusions: BNCT and gamma irradiations showed different genotoxic patterns. To our knowledge, these values represent the first experimental ones obtained for the RA-3 in a

  19. Feasibility of developing a portable driver performance data acquisition system for human factors research: Technical tasks. Volume 1

    SciTech Connect (OSTI)

    Carter, R.J.; Barickman, F.S.; Spelt, P.F.; Schmoyer, R.L.; Kirkpatrick, J.R.

    1998-01-01

    A two-phase, multi-year research program entitled ``development of a portable driver performance data acquisition system for human factors research`` was recently completed. The primary objective of the project was to develop a portable data acquisition system for crash avoidance research (DASCAR) that will allow drive performance data to be collected using a large variety of vehicle types and that would be capable of being installed on a given vehicle type within a relatively short-time frame. During phase 1 a feasibility study for designing and fabricating DASCAR was conducted. In phase 2 of the research DASCAR was actually developed and validated. This technical memorandum documents the results from the feasibility study. It is subdivided into three volumes. Volume one (this report) addresses the last five items in the phase 1 research and the first issue in the second phase of the project. Volumes two and three present the related appendices, and the design specifications developed for DASCAR respectively. The six tasks were oriented toward: identifying parameters and measures; identifying analysis tools and methods; identifying measurement techniques and state-of-the-art hardware and software; developing design requirements and specifications; determining the cost of one or more copies of the proposed data acquisition system; and designing a development plan and constructing DASCAR. This report also covers: the background to the program; the requirements for the project; micro camera testing; heat load calculations for the DASCAR instrumentation package in automobile trunks; phase 2 of the research; the DASCAR hardware and software delivered to the National Highway Traffic Safety Administration; and crash avoidance problems that can be addressed by DASCAR.

  20. A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice

    SciTech Connect (OSTI)

    Pierce, Anson; Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229; The Department of Veteran's Affairs, South Texas Veterans Health Care System, San Antonio, Texas, 78284 ; Wei, Rochelle; Halade, Dipti; Yoo, Si-Eun; Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229 ; Ran, Qitao; Richardson, Arlan; Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229; The Department of Veteran's Affairs, South Texas Veterans Health Care System, San Antonio, Texas, 78284

    2010-11-05

    Research highlights: {yields} Development of mouse overexpressing native human HSF1 in all tissues including CNS. {yields} HSF1 overexpression enhances heat shock response at whole-animal and cellular level. {yields} HSF1 overexpression protects from polyglutamine toxicity and favors aggresomes. {yields} HSF1 overexpression enhances proteostasis at the whole-animal and cellular level. -- Abstract: The heat shock response (HSR) is controlled by the master transcriptional regulator heat shock factor 1 (HSF1). HSF1 maintains proteostasis and resistance to stress through production of heat shock proteins (HSPs). No transgenic model exists that overexpresses HSF1 in tissues of the central nervous system (CNS). We generated a transgenic mouse overexpressing full-length non-mutant HSF1 and observed a 2-4-fold increase in HSF1 mRNA and protein expression in all tissues studied of HSF1 transgenic (HSF1{sup +/0}) mice compared to wild type (WT) littermates, including several regions of the CNS. Basal expression of HSP70 and 90 showed only mild tissue-specific changes; however, in response to forced exercise, the skeletal muscle HSR was more elevated in HSF1{sup +/0} mice compared to WT littermates and in fibroblasts following heat shock, as indicated by levels of inducible HSP70 mRNA and protein. HSF1{sup +/0} cells elicited a significantly more robust HSR in response to expression of the 82 repeat polyglutamine-YFP fusion construct (Q82YFP) and maintained proteasome-dependent processing of Q82YFP compared to WT fibroblasts. Overexpression of HSF1 was associated with fewer, but larger Q82YFP aggregates resembling aggresomes in HSF1{sup +/0} cells, and increased viability. Therefore, our data demonstrate that tissues and cells from mice overexpressing full-length non-mutant HSF1 exhibit enhanced proteostasis.

  1. Record of Decision Available

    Broader source: Energy.gov [DOE]

    DOE has recently published its Record of Decision announcing and explaining DOE’s chosen project alternative and describing any commitments for mitigating potential environmental impacts. The NEPA...

  2. Human Factors Guidance for Control Room and Digital Human-System Interface Design and Modification, Guidelines for Planning, Specification, Design, Licensing, Implementation, Training, Operation and Maintenance

    SciTech Connect (OSTI)

    R. Fink, D. Hill, J. O'Hara

    2004-11-30

    Nuclear plant operators face a significant challenge designing and modifying control rooms. This report provides guidance on planning, designing, implementing and operating modernized control rooms and digital human-system interfaces.

  3. Function allocation for humans and automation in the context of team dynamics

    SciTech Connect (OSTI)

    Jeffrey C. Joe; John O'Hara; Jacques Hugo; Johanna Oxstrand

    2015-07-01

    Within Human Factors Engineering, a decision-making process called function allocation (FA) is used during the design life cycle of complex systems to distribute the system functions, often identified through a functional requirements analysis, to all human and automated machine agents (or teammates) involved in controlling the system. Most FA methods make allocation decisions primarily by comparing the capabilities of humans and automation, but then also by considering secondary factors such as cost, regulations, and the health and safety of workers. The primary analysis of the strengths and weaknesses of humans and machines, however, is almost always considered in terms of individual human or machine capabilities. Yet, FA is fundamentally about teamwork in that the goal of the FA decision-making process is to determine what are the optimal allocations of functions among agents. Given this framing of FA, and the increasing use of and sophistication of automation, there are two related social psychological issues that current FA methods need to address more thoroughly. First, many principles for effective human teamwork are not considered as central decision points or in the iterative hypothesis and testing phase in most FA methods, when it is clear that social factors have numerous positive and negative effects on individual and team capabilities. Second, social psychological factors affecting team performance and can be difficult to translate to automated agents, and most FA methods currently do not account for this effect. The implications for these issues are discussed.

  4. Air Sparging Decision Tool

    Energy Science and Technology Software Center (OSTI)

    1996-06-10

    The Air Sparging Decision Tool is a computer decision aid to help environmental managers and field practitioners in evaluating the applicability of air sparging to a wide range of sites and for refining the operation of air sparging systems. The program provides tools for the practitioner to develop the conceptual design for an air sparging system suitable for the identified site. The Tool provides a model of the decision making process, not a detailed designmore » of air sparging systems. The Tool will quickly and cost effectively assist the practitioner in screening for applicability of the technology at a proposed site.« less

  5. Douglas Factors

    Broader source: Energy.gov [DOE]

    The Merit Systems Protection Board in its landmark decision, Douglas vs. Veterans Administration, 5 MSPR 280, established criteria that supervisors must consider in determining an appropriate penalty to impose for an act of employee misconduct. These twelve factors are commonly referred to as “Douglas Factors” and have been incorporated into the Federal Aviation Administration (FAA) Personnel Management System and various FAA Labor Agreements.

  6. Decision Summaries | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    January 16, 2014 Summary of Decisions - December 30, 2013 - January 3, 2014 Decisions were issued on: - Privacy Act Appeal January 10, 2014 Summary of Decisions - MM DD YYYY - MM...

  7. Distribution of polychlorinated biphenyls and organochlorine pesticides in human breast milk from various locations in Tunisia: Levels of contamination, influencing factors, and infant risk assessment

    SciTech Connect (OSTI)

    Ennaceur, S. Gandoura, N.; Driss, M.R.

    2008-09-15

    The concentrations of dichlorodiphenytrichloroethane and its metabolites (DDTs), hexachlorobenzene (HCB), hexachlorocyclohexane isomers (HCHs), dieldrin, and 20 polychlorinated biphenyls (PCBs) were determined in 237 human breast milk samples collected from 12 locations in Tunisia. Gas chromatography with electron capture detector (GC-ECD) was used to identify and quantify residue levels on a lipid basis of organochlorine compounds (OCs). The predominant OCs in human breast milk were PCBs, p,p'-DDE, p,p'-DDT, HCHs, and HCB. Concentrations of DDTs in human breast milk from rural areas were significantly higher than those from urban locations (p<0.05). With regard to PCBs, we observed the predominance of mid-chlorinated congeners due to the presence of PCBs with high K{sub ow} such as PCB 153, 138, and 180. Positive correlations were found between concentrations of OCs in human breast milk and age of mothers and number of parities, suggesting the influence of such factors on OC burdens in lactating mothers. The comparison of daily intakes of PCBs, DDTs, HCHs, and HCB to infants through human breast milk with guidelines proposed by WHO and Health Canada shows that some individuals accumulated OCs in breast milk close to or higher than these guidelines.

  8. Decision Summaries | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    December 21, 2012 Summary of Decisions - December 17, 2012 - December 21, 2012 Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)...

  9. Decision Summaries | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    January 16, 2015 Summary of Decisions - January 12, 2015 - January 16, 2015 Decisions were issued on: - Freedom of Information Act Appeal - Refund Proceeding January 9, 2015...

  10. Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells

    SciTech Connect (OSTI)

    Matsuzaki, Shinichi; Ishizuka, Tamotsu; Yamada, Hidenori; Kamide, Yosuke; Hisada, Takeshi; Ichimonji, Isao; Aoki, Haruka; Yatomi, Masakiyo; Komachi, Mayumi; Tsurumaki, Hiroaki; Ono, Akihiro; Koga, Yasuhiko; Dobashi, Kunio; Mogi, Chihiro; Sato, Koichi; Tomura, Hideaki; Mori, Masatomo; Okajima, Fumikazu

    2011-10-07

    Highlights: {yields} The involvement of extracellular acidification in airway remodeling was investigated. {yields} Extracellular acidification alone induced CTGF production in human ASMCs. {yields} Extracellular acidification enhanced TGF-{beta}-induced CTGF production in human ASMCs. {yields} Proton-sensing receptor OGR1 was involved in acidic pH-stimulated CTGF production. {yields} OGR1 may play an important role in airway remodeling in asthma. -- Abstract: Asthma is characterized by airway inflammation, hyper-responsiveness and remodeling. Extracellular acidification is known to be associated with severe asthma; however, the role of extracellular acidification in airway remodeling remains elusive. In the present study, the effects of acidification on the expression of connective tissue growth factor (CTGF), a critical factor involved in the formation of extracellular matrix proteins and hence airway remodeling, were examined in human airway smooth muscle cells (ASMCs). Acidic pH alone induced a substantial production of CTGF, and enhanced transforming growth factor (TGF)-{beta}-induced CTGF mRNA and protein expression. The extracellular acidic pH-induced effects were inhibited by knockdown of a proton-sensing ovarian cancer G-protein-coupled receptor (OGR1) with its specific small interfering RNA and by addition of the G{sub q/11} protein-specific inhibitor, YM-254890, or the inositol-1,4,5-trisphosphate (IP{sub 3}) receptor antagonist, 2-APB. In conclusion, extracellular acidification induces CTGF production through the OGR1/G{sub q/11} protein and inositol-1,4,5-trisphosphate-induced Ca{sup 2+} mobilization in human ASMCs.

  11. Structure of the human factor VIII C2 domain in complex with the 3E6 inhibitory antibody

    SciTech Connect (OSTI)

    Wuerth, Michelle E.; Cragerud, Rebecca K.; Spiegel, P. Clint

    2015-11-24

    Blood coagulation factor VIII is a glycoprotein cofactor that is essential for the intrinsic pathway of the blood coagulation cascade. Inhibitory antibodies arise either spontaneously or in response to therapeutic infusion of functional factor VIII into hemophilia A patients, many of which are specific to the factor VIII C2 domain. The immune response is largely parsed into “classical” and “non-classical” inhibitory antibodies, which bind to opposing faces cooperatively. In this study, the 2.61 Å resolution structure of the C2 domain in complex with the antigen-binding fragment of the 3E6 classical inhibitory antibody is reported. The binding interface is largely conserved when aligned with the previously determined structure of the C2 domain in complex with two antibodies simultaneously. Further inspection of the B factors for the C2 domain in various X-ray crystal structures indicates that 3E6 antibody binding decreases the thermal motion behavior of surface loops in the C2 domain on the opposing face, thereby suggesting that cooperative antibody binding is a dynamic effect. Furthermore, understanding the structural nature of the immune response to factor VIII following hemophilia A treatment will help lead to the development of better therapeutic reagents.

  12. Structure of the human factor VIII C2 domain in complex with the 3E6 inhibitory antibody

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wuerth, Michelle E.; Cragerud, Rebecca K.; Spiegel, P. Clint

    2015-11-24

    Blood coagulation factor VIII is a glycoprotein cofactor that is essential for the intrinsic pathway of the blood coagulation cascade. Inhibitory antibodies arise either spontaneously or in response to therapeutic infusion of functional factor VIII into hemophilia A patients, many of which are specific to the factor VIII C2 domain. The immune response is largely parsed into “classical” and “non-classical” inhibitory antibodies, which bind to opposing faces cooperatively. In this study, the 2.61 Å resolution structure of the C2 domain in complex with the antigen-binding fragment of the 3E6 classical inhibitory antibody is reported. The binding interface is largely conservedmore » when aligned with the previously determined structure of the C2 domain in complex with two antibodies simultaneously. Further inspection of the B factors for the C2 domain in various X-ray crystal structures indicates that 3E6 antibody binding decreases the thermal motion behavior of surface loops in the C2 domain on the opposing face, thereby suggesting that cooperative antibody binding is a dynamic effect. Furthermore, understanding the structural nature of the immune response to factor VIII following hemophilia A treatment will help lead to the development of better therapeutic reagents.« less

  13. Crystal Structure of the C-terminal Domain of the Subunit of Human Translation Initiation Factor eIF2B

    SciTech Connect (OSTI)

    Wei, J.; Jia, M; Zheng, C; Wang, M; Gao, F; Xu, H; Gong, W

    2010-01-01

    Eukaryotic translation initiation factor eIF2B, the guanine nucleotide exchange factor (GEF) for eIF2, catalyzes conversion of eIF2 {center_dot} GDP to eIF2 {center_dot} GTP. The eIF2B is composed of five subunits, {alpha}, {beta}, {gamma}, {delta} and {var_epsilon}, within which the {var_epsilon} subunit is responsible for catalyzing the guanine exchange reaction. Here we present the crystal structure of the C-terminal domain of human eIF2B{var_epsilon} (eIF2B{var_epsilon}-CTD) at 2.0-{angstrom} resolution. The structure resembles a HEAT motif and three charge-rich areas on its surface can be identified. When compared to yeast eIF2B{var_epsilon}-CTD, one area involves highly conserved AA boxes while the other two are only partially conserved. In addition, the previously reported mutations in human eIF2B{var_epsilon}-CTD, which are related to the loss of the GEF activity and human VWM disease, have been discussed. Based on the structure, most of such mutations tend to destabilize the HEAT motif.

  14. Lazy decision trees

    SciTech Connect (OSTI)

    Friedman, J.H.; Yun, Yeogirl; Kohavi, R.

    1996-12-31

    Lazy learning algorithms, exemplified by nearest-neighbor algorithms, do not induce a concise hypothesis from a given training set; the inductive process is delayed until a test instance is given. Algorithms for constructing decision trees, such as C4.5, ID3, and CART create a single {open_quotes}best{close_quotes} decision tree during the training phase, and this tree is then used to classify test instances. The tests at the nodes of the constructed tree are good on average, but there may be better tests for classifying a specific instance. We propose a lazy decision tree algorithm-LazyDT-that conceptually constructs the {open_quotes}best{close_quote} decision tree for each test instance. In practice, only a path needs to be constructed, and a caching scheme makes the algorithm fast. The algorithm is robust with respect to missing values without resorting to the complicated methods usually seen in induction of decision trees. Experiments on real and artificial problems are presented.

  15. Human-machine interactions

    DOE Patents [OSTI]

    Forsythe, J. Chris; Xavier, Patrick G.; Abbott, Robert G.; Brannon, Nathan G.; Bernard, Michael L.; Speed, Ann E.

    2009-04-28

    Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

  16. EIS-0236: Record of Decision

    Broader source: Energy.gov [DOE]

    Record of Decision Programmatic Environmental Impact Statement for Stockpile Stewardship and Management

  17. Robust Decision Making

    SciTech Connect (OSTI)

    Christopher A. Dieckmann, PE, CSEP-Acq

    2010-07-01

    The Idaho National Laboratory (INL) is funded through the Department of Energy (DOE) Office of Nuclear Energy and other customers who have direct contracts with the Laboratory. The people, equipment, facilities and other infrastructure at the laboratory require continual investment to maintain and improve the laboratory’s capabilities. With ever tightening federal and customer budgets, the ability to direct investments into the people, equipment, facilities and other infrastructure which are most closely aligned with the laboratory’s mission and customers’ goals grows increasingly more important. The ability to justify those investment decisions based on objective criteria that can withstand political, managerial and technical criticism also becomes increasingly more important. The Systems Engineering tools of decision analysis, risk management and roadmapping, when properly applied to such problems, can provide defensible decisions.

  18. Decision Impact Assessment Model

    Energy Science and Technology Software Center (OSTI)

    1991-08-01

    DIAMOND represents the decision-making environment that utility planners and executives face. Users interact with the model after every year or two of simulation, which provides an opportunity to modify past decisions as well as to make new decisions. For example, construction of a power plant can be started one year, and if circumstances change, the plant can be accelerated, mothballed, cancelled, or continued as originally planned. Similarly, the marketing and financial incentives for demand-side managementmore » programs can be changed from year to year. This frequent user interaction with the model, an operational game, should build greater understanding and insights among utility planners about the risks associated with different types of resources.« less

  19. Estrogen induced concentration dependent differential gene expression in human breast cancer (MCF7) cells: Role of transcription factors

    SciTech Connect (OSTI)

    Chandrasekharan, Sabarinath; Kandasamy, Krishna Kumar; Dayalan, Pavithra; Ramamurthy, Viraragavan

    2013-08-02

    Highlights: •Estradiol (E2) at low dose induced cell proliferation in breast cancer cells. •E2 at high concentration induced cell stress in breast cancer cells. •Estrogen receptor physically interacts only with a few transcription factors. •Differential expression of genes with Oct-1 binding sites increased under stress. •Transcription factor binding sites showed distinct spatial distribution on genes. -- Abstract: Background: Breast cancer cells respond to estrogen in a concentration dependent fashion, resulting in proliferation or apoptosis. The mechanism of this concentration dependent differential outcome is not well understood yet. Methodology: Meta-analysis of the expression data of MCF7 cells treated with low (1 nM) or high (100 nM) dose of estradiol (E2) was performed. We identified genes differentially expressed at the low or the high dose, and examined the nature of regulatory elements in the vicinity of these genes. Specifically, we looked for the difference in the presence, abundance and spatial distribution of binding sites for estrogen receptor (ER) and selected transcription factors (TFs) in the genomic region up to 25 kb upstream and downstream from the transcription start site (TSS) of these genes. Results: It was observed that at high dose E2 induced the expression of stress responsive genes, while at low dose, genes involved in cell cycle were induced. We found that the occurrence of transcription factor binding regions (TFBRs) for certain factors such as Sp1 and SREBP1 were higher on regulatory regions of genes expressed at low dose. At high concentration of E2, genes with a higher frequency of Oct-1 binding regions were predominantly involved. In addition, there were differences in the spatial distribution pattern of the TFBRs in the genomic regions among the two sets of genes. Discussion: E2 induced predominantly proliferative/metabolic response at low concentrations; but at high concentration, stress–rescue responses were induced. At high E2

  20. Peircean Decision Aid

    Energy Science and Technology Software Center (OSTI)

    2008-08-14

    The Peircean decision aid (PDA) is a decision support architecture and embedded functionality that supports a decision maker in very complex environments dealing with massive amounts of disparate data, information and knowledge. The solution generated is a hybrid system solution employing a number of technologies that are based on Peircean reasoning, modal logic, and formal concept analysis. The system convolves data/information with knowledge to create a virtual belief state that is passed to a decisionmore » maker for consideration. The system can capture categorized knowledge or it can inductively learn or acquire new knowledge from suites of observations. Captured knowledge is used to abductively generate hypotheses that are potential explanations to observations or collected data. The zero order modal logic architecture is designed to augment knowledge update and belief revision and can be extended to include disjunctive screening of collected data. While intended to be a library for integration into a decision support architecture it possesses a basic stand-alone GUI for use as an analysis support tool.« less

  1. Nuclear Factor I-C promotes proliferation and differentiation of apical papilla-derived human stem cells in vitro

    SciTech Connect (OSTI)

    Zhang, Jing; Wang, Zhihua; Jiang, Yong; Niu, Zhongying; Fu, Lei; Luo, Zhirong; Cooper, Paul R.; Smith, Anthony J.; He, Wenxi

    2015-03-15

    The transcription factor Nuclear Factor I-C (NFIC) has been implicated in the regulation of tooth root development, where it may be anticipated to impact on the behavior of stem cells from the apical papilla (SCAPs) and root odontoblast activity. We hypothesized that NFIC may provide an important target for promoting dentin/root regeneration. In the present study, the effects of NFIC on the proliferation and differentiation of SCAPs were investigated. Over-expression of NFIC increased cell proliferation, mineralization nodule formation and alkaline phosphatase (ALP) activity in SCAPs. Furthermore, NFIC up-regulated the mRNA levels of odontogenic-related markers, ALP, osteocalcin and collagen type I as well as dentin sialoprotein protein levels. In contrast, knockdown of NFIC by si-RNA inhibited the mineralization capacity of SCAPs and down-regulated the expression of odontogenic-related markers. In conclusion, the results indicated that upregulation of NFIC activity in SCAPs may promote osteo/odontoblastic differentiation of SCAPs. - Highlights: • NFIC promotes the proliferation of SCAPs in vitro. • NFIC promotes osteo/odontogenic differentiation of SCAPs in vitro. • Knockdown of NFIC inhibits odontogenic differentiation in SCAPs.

  2. The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: Down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin

    SciTech Connect (OSTI)

    Song Jin; Jie Chunfa; Polk, Paula; Shridhar, Ravi; Clair, Timothy; Zhang, Jun; Yin, Lijia; Keppler, Daniel . E-mail: dkeppl@lsuhsc.edu

    2006-02-03

    We recently coined CST6 as a novel candidate tumor suppressor gene for breast cancer. CST6 indeed is expressed in the normal human breast epithelium, but little or not at all in breast carcinomas and breast cancer cell lines. Moreover, ectopic expression of CST6 in human breast cancer cells suppressed cell proliferation, migration, invasion, and orthotopic tumor growth. To obtain insights into the molecular mechanism by which CST6 exhibits its pleiotropic effects on tumor cells, we compared global gene expression profiles in mock- and CST6-transfected human MDA-MB-435S cells. Out of 12,625 transcript species, 61 showed altered expression. These included genes for extracellular matrix components, cytokines, kinases, and phosphatases, as well as several key transcription factors. TaqMan PCR assays were used to confirm the microarray data for 7 out of 11 genes. One down-regulated gene product, secreted autotaxin/lyso-phospholipase D, was of particular interest because its down-regulation by CST6 could explain most of CST6's effect on the breast cancer cells. This study thus provides First evidence that CST6 plays a role in the modulation of genes, particularly, genes that are highly relevant to breast cancer progression.

  3. Decision Summaries | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    June 21, 2013 Summary of Decisions - June 17, 2013 - June 21, 2013 Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710) June 14,...

  4. Decision Summaries | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    July 10, 2015 Summary of Decisions - July 6, 2015 - July 10, 2015 Decisions were issued on: - Personnel Security (10 CFR Part 710) - Whistleblower Protection (10 CFR Part 708) July...

  5. Decision Summaries | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    July 25, 2014 Summary of Decisions - July 21, 2014 - July 25, 2014 Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710) July 18,...

  6. A human factors approach towards the design of a new glovebox glove for Los Alamos National Laboratory

    SciTech Connect (OSTI)

    Oka, Jude M.

    2012-08-06

    Present day glovebox gloves at Los Alamos National Laboratory (LANL) are underdeveloped and ergonomically inaccurate. This problem results in numerous sprain and strain injuries every year for employees who perform glovebox work. In addition to injuries, using the current glovebox glove design also contributes to breaches and contamination. The current glove used today at LANL has several problems: (1) The length of the fingers is incorrect, (2) the web spacing between the fingers is nonexistent, (3) the angles between each digit on the finger are incorrect, (4) the thumb is placed inaccurately, and (5) the length of the hand is incorrect. These problems present a need to correct the current glove design to decrease the risk of injuries, breaches, and contamination. Anthropometrics were researched to help find the best range of hand measurements to fix the current glove design. Anthropometrics is the measure of the human physical variation. Anthropometrics for this study were gathered from the American National Survey (ANSUR) data that was conducted by the U.S Army in 1988. The current glovebox glove uses anthropometrics from the 95th to 105th percentile range which is too large so the new gloves are going to implement data from a smaller range of percentile groups. The 105th percentile range represents measurements that exceed the human population but are needed to fit certain circumstance such as wearing several under gloves within the glovebox gloves. Anthropometrics used in this study include: 105th percentile measurements for joint circumference which was unchanged because the room for under gloves plus ease of hand insertion and extraction is needed, 80th percentile measurements for crotch length to allow workers to reach the web spacing in the glove, 20th percentile measurements for finger length to allow workers to reach the end of the glove, standard 10.5cm hand breadth to allow more room to accommodate under gloves, 45 degrees abduction angle for the

  7. EIS-0435: Record of Decision

    Broader source: Energy.gov [DOE]

    Record of Decision for the Modification of the Groton Generation Station Interconnection Agreement, Brown County, South Dakota (December 2011)

  8. ADR Lunchtime Program: How Do You Make Decisions? | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    How Do You Make Decisions? ADR Lunchtime Program: How Do You Make Decisions? May 14, 2015 "How Do You Make Decisions?" The study of NeuroEconomics is an emerging, interdisciplinary field that works to explain how humans make decisions. People in conflict may respond by working towards resolution, avoiding conflict, or becoming entrenched in their positions. The Speaker will discuss how the brain decides which way to respond and will offer language and tools to use in conflict

  9. Property:NEPA Decision | Open Energy Information

    Open Energy Info (EERE)

    Decision Jump to: navigation, search Property Name NEPA Decision Property Type Page Description Files documenting decisions on NEPA Docs This is a property of type Page. Pages...

  10. Kruppel-like factor 2 inhibit the angiogenesis of cultured human liver sinusoidal endothelial cells through the ERK1/2 signaling pathway

    SciTech Connect (OSTI)

    Zeng, Xiao-Qing; Li, Na; Pan, Du-Yi; Miao, Qing; Ma, Gui-Fen; Liu, Yi-Mei; Tseng, Yu-Jen; Li, Feng; Xu, Li-Li; Chen, Shi-Yao

    2015-09-04

    Kruppel-like factor 2 (KLF2) is a crucial anti-angiogenic factor. However, its precise role in hepatic angiogenesis induced by liver sinusoidal endothelial cells (LSECs) remain unclear. This study was aimed to evaluate the effect of KLF2 on angiogenesis of LSECs and to explore the corresponding mechanism. Cultured human LSECs were infected with different lentiviruses to overexpress or suppress KLF2 expression. The CCK-8 assay, transwell migration assay and tube formation test, were used to investigate the roles of KLF2 in the proliferation, migration and vessel tube formation of LSECs, respectively. The expression and phosphorylation of ERK1/2 were detected by western blot. We discovered that the up-regulation of KLF2 expression dramatically inhibited proliferation, migration and tube formation in treated LSECs. Correspondingly, down-regulation of KLF2 expression significantly promoted proliferation, migration and tube formation in treated LSECs. Additionally, KLF2 inhibited the phosphorylation of ERK1/2 pathway, followed by the function of KLF2 in the angiogenesis of LSECs disrupted. In conclusion, KLF2 suppressed the angiogenesis of LSECs through inhibition of cell proliferation, migration, and vessel tube formation. These functions of KLF2 may be mediated through the ERK1/2 signaling pathway. - Highlights: • Overexpression of KLF2 inhibits the proliferation and migration of LSECs. • Overexpression of KLF2 inhibits the angiogenesis of LSECs. • ERK1/2 signaling pathway involved in the anti-angiogenic process of KLF2 on LSECs.

  11. Fibroblast growth factor 2 inhibits up-regulation of bone morphogenic proteins and their receptors during osteoblastic differentiation of human mesenchymal stem cells

    SciTech Connect (OSTI)

    Biver, Emmanuel; Soubrier, Anne-Sophie; Thouverey, Cyril; Cortet, Bernard; Broux, Odile; Caverzasio, Joseph; Hardouin, Pierre

    2012-11-02

    Highlights: Black-Right-Pointing-Pointer FGF modulates BMPs pathway in HMSCs by down-regulating BMP/BMPR expression. Black-Right-Pointing-Pointer This effect is mediated by ERK and JNK MAPKs pathways. Black-Right-Pointing-Pointer Crosstalk between FGF and BMPs must be taken into account in skeletal bioengineering. Black-Right-Pointing-Pointer It must also be considered in the use of recombinant BMPs in orthopedic and spine surgeries. -- Abstract: Understanding the interactions between growth factors and bone morphogenic proteins (BMPs) signaling remains a crucial issue to optimize the use of human mesenchymal stem cells (HMSCs) and BMPs in therapeutic perspectives and bone tissue engineering. BMPs are potent inducers of osteoblastic differentiation. They exert their actions via BMP receptors (BMPR), including BMPR1A, BMPR1B and BMPR2. Fibroblast growth factor 2 (FGF2) is expressed by cells of the osteoblastic lineage, increases their proliferation and is secreted during the healing process of fractures or in surgery bone sites. We hypothesized that FGF2 might influence HMSC osteoblastic differentiation by modulating expressions of BMPs and their receptors. BMP2, BMP4, BMPR1A and mainly BMPR1B expressions were up-regulated during this differentiation. FGF2 inhibited HMSCs osteoblastic differentiation and the up-regulation of BMPs and BMPR. This effect was prevented by inhibiting the ERK or JNK mitogen-activated protein kinases which are known to be activated by FGF2. These data provide a mechanism explaining the inhibitory effect of FGF2 on osteoblastic differentiation of HMSCs. These crosstalks between growth and osteogenic factors should be considered in the use of recombinant BMPs in therapeutic purpose of fracture repair or skeletal bioengineering.

  12. Record of Decision for Amchitka Surface Closure, Alaska

    SciTech Connect (OSTI)

    2008-08-01

    This Record of Decision has been prepared to document the remedial actions taken on Amchitka Island to stabilize contaminants associated with drilling mud pits generated as a result of nuclear testing operations conducted on the island. This document has been prepared in accordance with the recommended outline in the Alaska Department of Environmental Conservation guidance on decision documentation under the Site Cleanup Rules (18 AAC 75.325-18 AAC 75.390) (ADEC 1999). It also describes the decision-making process used to establish the remedial action plans and defines the associated human health and ecological risks for the remediation.

  13. Training Adaptive Decision-Making.

    SciTech Connect (OSTI)

    Abbott, Robert G.; Forsythe, James C.

    2014-10-01

    Adaptive Thinking has been defined here as the capacity to recognize when a course of action that may have previously been effective is no longer effective and there is need to adjust strategy. Research was undertaken with human test subjects to identify the factors that contribute to adaptive thinking. It was discovered that those most effective in settings that call for adaptive thinking tend to possess a superior capacity to quickly and effectively generate possible courses of action, as measured using the Category Generation test. Software developed for this research has been applied to develop capabilities enabling analysts to identify crucial factors that are predictive of outcomes in fore-on-force simulation exercises.

  14. Requirements to coordinate agreements, milestones and decision...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    to coordinate agreements, milestones and decision documents (AMDD) Requirements to coordinate agreements, milestones and decision documents (AMDD) Environmental agreements,...

  15. Latent effects decision analysis

    DOE Patents [OSTI]

    Cooper, J. Arlin; Werner, Paul W.

    2004-08-24

    Latent effects on a system are broken down into components ranging from those far removed in time from the system under study (latent) to those which closely effect changes in the system. Each component is provided with weighted inputs either by a user or from outputs of other components. A non-linear mathematical process known as `soft aggregation` is performed on the inputs to each component to provide information relating to the component. This information is combined in decreasing order of latency to the system to provide a quantifiable measure of an attribute of a system (e.g., safety) or to test hypotheses (e.g., for forensic deduction or decisions about various system design options).

  16. Administrator's Final Record of Decision

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with my recent decision during the Integrated Program Review to convert funding for BPA's Energy Efficiency program from capital to expense, eliminating the growth of long-term...

  17. Waste-to-energy: Decision-making and the decisions made

    SciTech Connect (OSTI)

    Schexnayder, S.M. ); Wolfe, A.K. )

    1993-01-01

    During the early 1980's, the number of municipalities considering waste-to-energy (WTE) facilities as a solid waste management option led to projections that WTE would be used to manage as much as half of all municipal solid waste by the turn of the century. However, during the latter part of the 1980's, the cancellation rate for WTE facilities grew to the point that its long-term future is questionable. This research sought to identify and examine the range of factors that influence municipalities' decisions concerning WTE. As part of a larger study, case studies of four communities that recently faced decisions about WTE facilities were undertaken. At two of the sites WTE projects formally were approved, while at the other two sites planned WTE facilities were canceled. The study distinguished between the decision-making process and the decision outcomes while recognizing that all aspects of the process clearly are linked to outcome. Case study findings indicate that like processes need not lead to like outcomes. Further, decisions do not fall neatly into simple acceptance'' or rejection'' categories.

  18. The anti-tumor effect of cross-reacting material 197, an inhibitor of heparin-binding EGF-like growth factor, in human resistant ovarian cancer

    SciTech Connect (OSTI)

    Tang, Xiao-han; Deng, Suo; Li, Meng; Lu, Mei-song

    2012-06-15

    Highlights: Black-Right-Pointing-Pointer HB-EGF over-expression in A2780/Taxol, A2780/CDDP cells and the matched xenografts. Black-Right-Pointing-Pointer CRM197 induces enhanced apoptosis in A2780/Taxol and A2780/CDDP cells. Black-Right-Pointing-Pointer CRM197 arrests A2780/Taxol and A2780/CDDP cells at G0/G1 phase. Black-Right-Pointing-Pointer CRM197 suppressed the A2780/Taxol and A2780/CDDP growth of xenografts. -- Abstract: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for ovarian cancer therapy. Cross-reacting material 197 (CRM197), a specific HB-EGF inhibitor, has been proven to represent possible chemotherapeutic agent for ovarian cancer. However, the effect of CRM197 on the resistant ovarian carcinoma cells has not been sufficiently elucidated. Here, we found that HB-EGF was over-expressed in a paclitaxel-resistant human ovarian carcinoma cell line (A2780/Taxol) and a cisplatin-resistant cell line (A2780/CDDP), as well as the xenograft mouse tissue samples with these cells. To investigate the possible significance of the HB-EGF over-expression in A2780/Taxol and A2780/CDDP cells, we inhibited HB-EGF expression by CRM197 to investigate the effect of CRM197 treatment on these cells. We observed that CRM197 significantly induced anti-proliferative activity in a dose-dependent manner with the cell-cycle arrest at the G0/G1 phase and enhanced apoptosis in A2780/Taxol and A2780/CDDP cells. The sensitive ovarian carcinoma parental cell line (A2780), A2780/Taxol and A2780/CDDP cells formed tumors in nude mice, and enhanced tumorigenicity was observed in drug-resistant tumors. Furthermore, we observed that CRM197 significantly suppressed the growth of drug-resistant ovarian cancer xenografts in vivo (p < 0.001). These results suggest that CRM197 as an HB-EGF-targeted agent has potent anti-tumor activity in paclitaxel- and cisplatin-resistant ovarian cancer which over-express HB-EGF.

  19. Decision Analysis for EGS | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Decision Analysis for EGS Decision Analysis for EGS Decision Analysis for EGS presentation at the April 2013 peer review meeting held in Denver, Colorado. decision_egs_einstein_peer2013.pdf (911.67 KB) More Documents & Publications Decision Analysis for EGS Seismic Technology Adapted to Analyzing and Developing Geothermal Systems Below Surface-Exposed High-Velocity Rocks Alum Innovative Exploration

  20. Decision Support Tool: Integrated REDD+ accounting frameworks...

    Open Energy Info (EERE)

    Decision Support Tool: Integrated REDD+ accounting frameworks: Nested national approaches Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Decision Support Tool:...

  1. Record of Decision (ROD) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Projects October 25, 2005 EIS-0374: Record of Decision Klondike III Biglow Canyon Wind Integration Project September 21, 2005 EIS-0355: Record of Decision Remediation...

  2. Record of Decision (ROD) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    0, 2003 EIS-0349: Record of Decision Electrical Interconnection of the BP Cherry Point Cogeneration Project October 31, 2003 EIS-0312: Record of Decision Fish and Wildlife...

  3. Record of Decision (ROD) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    19, 2012 EIS-0425: Record of Decision and Mitigation Action Plan Bonneville Power Administration Record of Decision and Mitigation Action Plan for the Mid-Columbia Restoration...

  4. Record of Decision (ROD) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    December 15, 1999 EIS-0281: Record of Decision Sandia National LaboratoriesNew Mexico Site-Wide Environmental Impact Statement November 12, 1999 EIS-0222: Record of Decision...

  5. RETScreen International Clean Energy Decision Support Centre...

    Open Energy Info (EERE)

    decision-making tools (i.e. RETScreen Software) that reduce the cost of pre-feasibility studies; disseminating knowledge to help people make better decisions; and by...

  6. Government Performance Result Act (GPRA) / Portfolio Decision...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Government Performance Result Act (GPRA) Portfolio Decision Support (PDS) Government Performance Result Act (GPRA) Portfolio Decision Support (PDS) 2009 DOE Hydrogen Program...

  7. iRESM INITIATIVE UNDERSTANDING DECISION SUPPORT NEEDS FOR CLIMATE CHANGE MITIGATION AND ADAPTATION --US Midwest Region—

    SciTech Connect (OSTI)

    Rice, Jennie S.; Runci, Paul J.; Moss, Richard H.; Anderson, Kate L.

    2010-10-01

    The impacts of climate change are already affecting human and environmental systems worldwide, yet many uncertainties persist in the prediction of future climate changes and impacts due to limitations in scientific understanding of relevant causal factors. In particular, there is mounting urgency to efforts to improve models of human and environmental systems at the regional scale, and to integrate climate, ecosystem and energy-economic models to support policy, investment, and risk management decisions related to climate change mitigation (i.e., reducing greenhouse gas emissions) and adaptation (i.e., responding to climate change impacts). The Pacific Northwest National Laboratory (PNNL) is developing a modeling framework, the integrated Regional Earth System Model (iRESM), to address regional human-environmental system interactions in response to climate change and the uncertainties therein. The framework will consist of a suite of integrated models representing regional climate change, regional climate policy, and the regional economy, with a focus on simulating the mitigation and adaptation decisions made over time in the energy, transportation, agriculture, and natural resource management sectors.

  8. Program Evaluation: Informed Decisions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Why, What, & When to Evaluate » Program Evaluation: Informed Decisions Program Evaluation: Informed Decisions Evaluation activities support decision-making that can contribute to efficient and effective management of programs. Evaluative information should be available to inform decisions made during the critical planning, budgeting, analysis, implementation, and benefits reporting/ communications cycles of the program. Program evaluation can provide essential information to inform

  9. Initial Decision and Risk Analysis

    SciTech Connect (OSTI)

    Engel, David W.

    2012-02-29

    Decision and Risk Analysis capabilities will be developed for industry consideration and possible adoption within Year 1. These tools will provide a methodology for merging qualitative ranking of technology maturity and acknowledged risk contributors with quantitative metrics that drive investment decision processes. Methods and tools will be initially introduced as applications to the A650.1 case study, but modular spreadsheets and analysis routines will be offered to industry collaborators as soon as possible to stimulate user feedback and co-development opportunities.

  10. IDHEAS – A NEW APPROACH FOR HUMAN RELIABILITY ANALYSIS

    SciTech Connect (OSTI)

    G. W. Parry; J.A Forester; V.N. Dang; S. M. L. Hendrickson; M. Presley; E. Lois; J. Xing

    2013-09-01

    This paper describes a method, IDHEAS (Integrated Decision-Tree Human Event Analysis System) that has been developed jointly by the US NRC and EPRI as an improved approach to Human Reliability Analysis (HRA) that is based on an understanding of the cognitive mechanisms and performance influencing factors (PIFs) that affect operator responses. The paper describes the various elements of the method, namely the performance of a detailed cognitive task analysis that is documented in a crew response tree (CRT), and the development of the associated time-line to identify the critical tasks, i.e. those whose failure results in a human failure event (HFE), and an approach to quantification that is based on explanations of why the HFE might occur.

  11. Record of Decision (ROD) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the Shepherds Flat Wind Energy Project June 10, 2008 EIS-0378: Record of Decision Port Angeles-Juan de Fuca Transmssion Proj June 4, 2008 EIS-0183: Record of Decision Electrical...

  12. Record of Decision (ROD) | Department of Energy

    Energy Savers [EERE]

    August 5, 2016 EIS-0491: Record of Decision (Lake Charles LNG Export Company, LLC) Lake ... DOE announced its decision in Lake Charles Exports, LLC (LCE), DOEFE Docket No. 11-59-LNG...

  13. Record of Decision for Mars 2020 Mission

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Record of Decision for Mars 2020 Mission Mars 2020 Rover instrument selection. Mars 2020 Rover instrument selection. NASA issued a record of decision (ROD) to use a nuclear battery ...

  14. Summary of Decisions- July 9- 13, 2012

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710) - Application for Exception

  15. EIS-0218: Revised Record of Decision

    Office of Energy Efficiency and Renewable Energy (EERE)

    Revision of the Record of Decision for a Nuclear Weapons Nonproliferation Policy Concerning Foreign Research Reactor Spent Nuclear Fuel

  16. Risk perception & strategic decision making :general insights, a framework, and specific application to electricity generation using nuclear energy.

    SciTech Connect (OSTI)

    Brewer, Jeffrey D.

    2005-11-01

    The objective of this report is to promote increased understanding of decision making processes and hopefully to enable improved decision making regarding high-consequence, highly sophisticated technological systems. This report brings together insights regarding risk perception and decision making across domains ranging from nuclear power technology safety, cognitive psychology, economics, science education, public policy, and neural science (to name a few). It forms them into a unique, coherent, concise framework, and list of strategies to aid in decision making. It is suggested that all decision makers, whether ordinary citizens, academics, or political leaders, ought to cultivate their abilities to separate the wheat from the chaff in these types of decision making instances. The wheat includes proper data sources and helpful human decision making heuristics; these should be sought. The chaff includes ''unhelpful biases'' that hinder proper interpretation of available data and lead people unwittingly toward inappropriate decision making ''strategies''; obviously, these should be avoided. It is further proposed that successfully accomplishing the wheat vs. chaff separation is very difficult, yet tenable. This report hopes to expose and facilitate navigation away from decision-making traps which often ensnare the unwary. Furthermore, it is emphasized that one's personal decision making biases can be examined, and tools can be provided allowing better means to generate, evaluate, and select among decision options. Many examples in this report are tailored to the energy domain (esp. nuclear power for electricity generation). The decision making framework and approach presented here are applicable to any high-consequence, highly sophisticated technological system.

  17. Record of Decision for Ground Water | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision for Ground Water Record of Decision for Ground Water Record of Decision for Ground Water (April 1997) Record of Decision for Ground Water (625.12 KB) More Documents & Publications EIS-0198: Record of Decision EIS-0170: Record of Decision (April 1997) EIS-0251: Second Record of Decision (May 1997)

  18. EIS-0378: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    : Record of Decision EIS-0378: Record of Decision Port Angeles-Juan de Fuca Transmssion Project The Department of Energy announces its decision to implement its proposed actions...

  19. Summary of Decisions - March 16, 2015 - March 20, 2015 | Department...

    Broader source: Energy.gov (indexed) [DOE]

    No decisions were issued during this week. Addthis Related Articles Summary of Decisions - March 2, 2015 - March 6, 2015 Summary of Decisions - November 2, 2015 - November 6, 2015...

  20. EIS-0323: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Decision EIS-0323: Record of Decision Record of Decision for the Sacramento Area Voltage Support Environmental Impact Statement (DOEEIS-0323) (011204) PDF icon Record of...

  1. EIS-0410: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    0: Record of Decision EIS-0410: Record of Decision Keystone Oil Pipeline Project Record of Decision for the Western Area Power Administration to modify three existing substation...

  2. EIS-0395: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Decision EIS-0395: Record of Decision San Luis Rio Colorado Project PDF icon Record of Decision for the Western Area Power Administration San Luis Rio Colorado Project, DOE...

  3. EIS-0289: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    9: Record of Decision EIS-0289: Record of Decision JEA Circulating Fluidized Bed Combustor Project, Jacksonville, Duval County, FL Record of Decision; JEA Circulating Fluidized Bed...

  4. EIS-0229: Amended Record of Decision (April 2002) | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Decision (April 2002) EIS-0229: Amended Record of Decision (April 2002) Surplus Plutonium Disposition Program Amended Record of Decision: The U.S. Department of Energy's National...

  5. EIS-0247: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0247: Record of Decision Construction and Operation of the Spallation Neutron Source The Department of Energy (DOE) is issuing this Record of Decision (ROD)...

  6. EIS-0383: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0383: Record of Decision Orlando Gasification Project, Orlando, Orange County, FL Record of Decision for the environmental impact statement (EIS) (DOE...

  7. EIS-0474: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0474: Record of Decision Southline Transmission Line Project; Arizona and New Mexico DOE's Western Area Power Administration issued a Record of Decision for ...

  8. cognitive-based-decision-making

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    November 29, 2011 From Cognitive-Based Decision Making To Car-Following Modeling: Beyond an Accident-Free Environment Dr. Samer Hamdar Assistant professor, George Washington University Tuesday, November 29, 2011 - 10am Argonne TRACC Building 222, Room D-233 In the year 2005, the monetary cost of injuries related to traffic accidents reached 625 billion USD (U. S. Dollars) in the U.S.A. only. Based on the National Highway Traffic Safety Agency (NHSTA) studies, 5 accident types of interest can be

  9. North Dome decision expected soon

    SciTech Connect (OSTI)

    Not Available

    1981-08-01

    Decisions soon will be made which will set in motion the development of Qatar's huge North Dome gas field. The government and state company, Qatar General Petroleum Corp. (QGPC) is studying the results of 2 feasibility studies on the economics of LNG export, although initially North Dome exploitation will be aimed at the domestic market. Decisions on the nature and timing of the North Dome development are the most important that have had to be faced in the short 10-yr history of the small Gulf state. The country's oil production is currently running at approximately 500,000 bpd, with 270,000 bpd originating from 3 offshore fields. Output is expected to decline through 1990, and it generally is accepted that there is little likelihood of further major crude discoveries. Therefore, Qatar has to begin an adjustment from an economy based on oil to one based on gas, while adhering to the underlying tenets of long-term conservation and industrial diversification.

  10. The eukaryotic translation elongation factor eEF1A2 induces neoplastic properties and mediates tumorigenic effects of ZNF217 in precursor cells of human ovarian carcinomas

    SciTech Connect (OSTI)

    Sun, Yu; Wong, Nicholas; Guan, Yinghui; Salamanca, Clara M.; Cheng, Jung Chien; Lee, Jonathan M.; Gray, Joe W.; Auersperg, Nelly

    2008-04-25

    Ovarian epithelial carcinomas (OEC) frequently exhibit amplifications at the 20q13 locus which is the site of several oncogenes, including the eukaryotic elongation factor EEF1A2 and the transcription factor ZNF217. We reported previously that overexpressed ZNF217 induces neoplastic characteristics in precursor cells of OEC. Unexpectedly, ZNF217, which is a transcriptional repressor, enhanced expression of eEF1A2. In this study, array comparative genomic hybridization, single nucleotide polymorphism and Affymetrix analysis of ZNF217-overexpressing cell lines confirmed consistently increased expression of eEF1A2 but not of other oncogenes, and revealed early changes in EEF1A2 gene copy numbers and increased expression at crisis during immortalization. We defined the influence of eEF1A2 overexpression on immortalized ovarian surface epithelial cells, and investigated interrelationships between effects of ZNF217 and eEF1A2 on cellular phenotypes. Lentivirally induced eEF1A2 overexpression caused delayed crisis, apoptosis resistance and increases in serum-independence, saturation densities, and anchorage independence. siRNA to eEF1A2 reversed apoptosis resistance and reduced anchorage independence in eEF1A2-overexpressing lines. Remarkably, siRNA to eEF1A2 was equally efficient in inhibiting both anchorage independence and resistance to apoptosis conferred by ZNF217 overexpression. Our data define neoplastic properties that are caused by eEF1A2 in nontumorigenic ovarian cancer precursor cells, and suggest that eEF1A2 plays a role in mediating ZNF217-induced neoplastic progression.

  11. Facts about the Plutonium Record of Decision | National Nuclear Security

    National Nuclear Security Administration (NNSA)

    Administration | (NNSA) Facts about the Plutonium Record of Decision Facts about the Plutonium Record of Decision

  12. Critical Decision Handbook | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Critical Decision Handbook Critical Decision Handbook This Handbook is designed as a practical tool for the Office of Environmental Management (EM) Federal Project Directors (FPDs), Integrated Project Teams (IPTs), Technical Authority Board (TAB), and senior management to ensure that issues and risks that could challenge the success of EM projects are identified early and proactively addressed. Critical Decision Handbook (3.64 MB) More Documents & Publications Standard Review Plan - Overview

  13. Portsmouth Decontamination and Decommissioning Record of Decision |

    Energy Savers [EERE]

    Department of Energy Decontamination and Decommissioning Record of Decision Portsmouth Decontamination and Decommissioning Record of Decision The Ohio Environmental Protection Agency (Ohio EPA) and the U.S. Department of Energy (DOE) have agreed upon a plan to demolish the large process buildings and other facilities undergoing decontamination and decommissioning (D&D) at the Portsmouth Gaseous Diffusion Plant. The Record of Decision (ROD) for the Process Buildings and Complex Facilities

  14. Creating ensembles of decision trees through sampling

    DOE Patents [OSTI]

    Kamath, Chandrika; Cantu-Paz, Erick

    2005-08-30

    A system for decision tree ensembles that includes a module to read the data, a module to sort the data, a module to evaluate a potential split of the data according to some criterion using a random sample of the data, a module to split the data, and a module to combine multiple decision trees in ensembles. The decision tree method is based on statistical sampling techniques and includes the steps of reading the data; sorting the data; evaluating a potential split according to some criterion using a random sample of the data, splitting the data, and combining multiple decision trees in ensembles.

  15. Record of Decision (ROD) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    EIS-0218: Revision to the Record of Decision Proposed Nuclear Weapons Nonproliferation Policy Concerning Foreign Research Reactor Spent Nuclear Fuel July 1, 2000 EIS-0285:...

  16. Tank Farm Area Cleanup Decision-Making

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Area Cleanup Decision-Making Groundwater Vadose Zone Single Shell Tank System Closure (tanks, structures and pipelines) * Washington State Hazardous Waste Management Act (Resource...

  17. Record of Decision (ROD) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Amendment to Record of Decision Spent Nuclear Fuel Management and Idaho National Engineering Laboratory Environmental Restoration and Waste Management Programs March 7,...

  18. Simulation, Modeling & Decision Science | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Laboratory focuses on integration of information technologies and cognition into the engineering process to support decision making for and the realization of...

  19. The energy investment decision in the nonresidential building sector: Research into the areas of influence

    SciTech Connect (OSTI)

    Harkreader, S.A.; Ivey, D.L.

    1987-04-01

    The purpose of this report is to describe and to characterize the decision process in the nonresidential building sector as well as the variables influencing energy investment decisions, both of which impact the development of R and D agendas for the Office of Building and Community Systems (BCS). The report reviews the available information on the factors that influence energy investment decisions and identifies information gaps where additional research is needed. This report focuses on variables and combinations of these variables (descriptive states) that influence the non residential energy investment decision maker. Economic and demographic descriptors, energy investment decision maker characteristics, and variables affecting energy investments are identified. This response examines the physical characteristics of buildings, characteristics of the legal environment surrounding buildings, demographic factors, economic factors, and decision processes, all of which impact the nonresidential energy investment market. The emphasis of the report is on providing possible methodologies for projecting the future of the nonresidential energy investment market, as well as, collecting the data necessary for such projections. The use of alternate scenarios is suggested as a projection tool and suggestions for collecting the appropriate data are made in the recommendations.

  20. Human System Simulation in Support of Human Performance Technical Basis at NPPs

    SciTech Connect (OSTI)

    David Gertman; Katya Le Blanc; alan mecham; william phoenix; Magdy Tawfik; Jeffrey Joe

    2010-06-01

    This paper focuses on strategies and progress toward establishing the Idaho National Laboratory’s (INL’s) Human Systems Simulator Laboratory at the Center for Advanced Energy Studies (CAES), a consortium of Idaho State Universities. The INL is one of the National Laboratories of the US Department of Energy. One of the first planned applications for the Human Systems Simulator Laboratory is implementation of a dynamic nuclear power plant simulation (NPP) where studies of operator workload, situation awareness, performance and preference will be carried out in simulated control rooms including nuclear power plant control rooms. Simulation offers a means by which to review operational concepts, improve design practices and provide a technical basis for licensing decisions. In preparation for the next generation power plant and current government and industry efforts in support of light water reactor sustainability, human operators will be attached to a suite of physiological measurement instruments and, in combination with traditional Human Factors Measurement techniques, carry out control room tasks in simulated advanced digital and hybrid analog/digital control rooms. The current focus of the Human Systems Simulator Laboratory is building core competence in quantitative and qualitative measurements of situation awareness and workload. Of particular interest is whether introduction of digital systems including automated procedures has the potential to reduce workload and enhance safety while improving situation awareness or whether workload is merely shifted and situation awareness is modified in yet to be determined ways. Data analysis is carried out by engineers and scientists and includes measures of the physical and neurological correlates of human performance. The current approach supports a user-centered design philosophy (see ISO 13407 “Human Centered Design Process for Interactive Systems, 1999) wherein the context for task performance along with the

  1. Decision making, procedural compliance, and outcomes definition in U.S. forest service planning processes

    SciTech Connect (OSTI)

    Stern, Marc J.; Predmore, S. Andrew

    2011-04-15

    The National Environmental Policy Act (NEPA) dictates a process of analyzing and disclosing the likely impacts of proposed agency actions on the human environment. This study addresses two key questions related to NEPA implementation in the U.S. Forest Service: 1) how do Interdisciplinary (ID) team leaders and decision makers conceptualize the outcomes of NEPA processes? And 2), how does NEPA relate to agency decision making? We address these questions through two separate online surveys that posed questions about recently completed NEPA processes - the first with the ID team leaders tasked with carrying out the processes, and the second with the line officers responsible for making the processes' final decisions. Outcomes of NEPA processes include impacts on public relations, on employee morale and team functioning, on the achievement of agency goals, and on the achievement of NEPA's procedural requirements (disclosure) and substantive intent (minimizing negative environmental impacts). Although both tended to view public relations outcomes as important, decision makers' perceptions of favorable outcomes were more closely linked to the achievement of agency goals and process efficiency than was the case for ID team leaders. While ID team leaders' responses suggest that they see decision making closely integrated with the NEPA process, decision makers more commonly decoupled decision making from the NEPA process. These findings suggest a philosophical difference between ID team leaders and decision makers that may pose challenges for both the implementation and the evaluation of agency NEPA. We discuss the pros and cons of integrating NEPA with decision making or separating the two. We conclude that detaching NEPA from decision making poses greater risks than integrating them.

  2. Science-based HRA: experimental comparison of operator performance to IDAC (Information-Decision-Action Crew) simulations

    SciTech Connect (OSTI)

    Shirley, Rachel; Smidts, Carol; Boring, Ronald; Li, Yuandan; Mosleh, Ali

    2015-02-01

    Information-Decision-Action Crew (IDAC) operator model simulations of a Steam Generator Tube Rupture are compared to student operator performance in studies conducted in the Ohio State University’s Nuclear Power Plant Simulator Facility. This study is presented as a prototype for conducting simulator studies to validate key aspects of Human Reliability Analysis (HRA) methods. Seven student operator crews are compared to simulation results for crews designed to demonstrate three different decision-making strategies. The IDAC model used in the simulations is modified slightly to capture novice behavior rather that expert operators. Operator actions and scenario pacing are compared. A preliminary review of available performance shaping factors (PSFs) is presented. After the scenario in the NPP Simulator Facility, student operators review a video of the scenario and evaluate six PSFs at pre-determined points in the scenario. This provides a dynamic record of the PSFs experienced by the OSU student operators. In this preliminary analysis, Time Constraint Load (TCL) calculated in the IDAC simulations is compared to TCL reported by student operators. We identify potential modifications to the IDAC model to develop an “IDAC Student Operator Model.” This analysis provides insights into how similar experiments could be conducted using expert operators to improve the fidelity of IDAC simulations.

  3. Adaptive awareness for personal and small group decision making.

    SciTech Connect (OSTI)

    Perano, Kenneth J.; Tucker, Steve; Pancerella, Carmen M.; Doser, Adele Beatrice; Berry, Nina M.; Kyker, Ronald D.

    2003-12-01

    Many situations call for the use of sensors monitoring physiological and environmental data. In order to use the large amounts of sensor data to affect decision making, we are coupling heterogeneous sensors with small, light-weight processors, other powerful computers, wireless communications, and embedded intelligent software. The result is an adaptive awareness and warning tool, which provides both situation awareness and personal awareness to individuals and teams. Central to this tool is a sensor-independent architecture, which combines both software agents and a reusable core software framework that manages the available hardware resources and provides services to the agents. Agents can recognize cues from the data, warn humans about situations, and act as decision-making aids. Within the agents, self-organizing maps (SOMs) are used to process physiological data in order to provide personal awareness. We have employed a novel clustering algorithm to train the SOM to discern individual body states and activities. This awareness tool has broad applicability to emergency teams, military squads, military medics, individual exercise and fitness monitoring, health monitoring for sick and elderly persons, and environmental monitoring in public places. This report discusses our hardware decisions, software framework, and a pilot awareness tool, which has been developed at Sandia National Laboratories.

  4. Eielson Air Force Base operable unit 2 and other areas record of decision

    SciTech Connect (OSTI)

    Lewis, R.E.; Smith, R.M.

    1994-10-01

    This decision document presents the selected remedial actions and no action decisions for Operable Unit 2 (OU2) at Eielson Air Force Base (AFB), Alaska, chosen in accordance with state and federal regulations. This document also presents the decision that no further action is required for 21 other source areas at Eielson AFB. This decision is based on the administrative record file for this site. OU2 addresses sites contaminated by leaks and spills of fuels. Soils contaminated with petroleum products occur at or near the source of contamination. Contaminated subsurface soil and groundwater occur in plumes on the top of a shallow groundwater table that fluctuates seasonally. These sites pose a risk to human health and the environment because of ingestion, inhalation, and dermal contact with contaminated groundwater. The purpose of this response is to prevent current or future exposure to the contaminated groundwater, to reduce further contaminant migration into the groundwater, and to remediate groundwater.

  5. Comparison of AB2588 multipathway risk factors for California fossil-fuel power stations

    SciTech Connect (OSTI)

    Gratt, L.B.; Levin, L.

    1997-12-31

    Substances released from power plants may travel through various exposure pathways resulting in human health and environmental risks. The stack air emission`s primary pathway is inhalation from the ambient air. Multipathway factors (adjustment factors to the inhalation risk) are used to evaluate the importance of non-inhalation pathways (such as ingestion and dermal contact). The multipathway factor for a specific substance is the health risk by all pathways divided by the inhalation health risk for that substance. These factors are compared for fossil fuel power stations that submitted regulatory risk assessments in compliance with California Toxic Hot Spots Act (AB2588). Substances representing the largest contributions to the cancer risk are of primary concern: arsenic, beryllium, cadmium, chromium (+6), formaldehyde, nickel, lead, selenium, and PAHs. Comparisons of the chemical-specific multipathway factors show the impacts of regulatory policy decisions on the estimated health risk for trace substances. As an example, point estimates of the soil mixing depth, varying from 1 cm to 15 cm, relate to the relative importance of the pathway. For the deeper mixing depths, the root-zone uptake by homegrown tomato plants (for assumed consumption rate of 15% for San Diego) may result in high multipathway factors for several trace metals. For shallower mixing depths, soil ingestion may become the dominant non-inhalation pathway. These differences may lead to significantly different risk estimates for similar facilities located at different California locations such as to be under local regulatory authorities. The overall multipathway factor for the total cancer risk is about 2, much smaller than some of the chemical-specific factors. Science-based multipathway analysis should reduce much of the concern that may be due to policy-based decisions on pathway selection and high-value point-estimates of the parameters.

  6. Summary of Decisions - February 8, 2016 - February 12, 2016 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 8, 2016 - February 12, 2016 Summary of Decisions - February 8, 2016 - February 12, 2016 February 12, 2016 - 1:44pm Addthis No reportable decisions were issued during this week Addthis Related Articles Summary of Decisions - December 24, 2012 - December 28, 2012 Summary of Decisions - December 31, 2012 - January 4, 2013 Summary of Decisions - March 2, 2015 - March 6

  7. Summary of Decisions - December 24, 2012 - December 28, 2012 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 24, 2012 - December 28, 2012 Summary of Decisions - December 24, 2012 - December 28, 2012 December 28, 2012 - 1:22pm Addthis No decisions were issued during this week. Addthis Related Articles Summary of Decisions - December 31, 2012 - January 4, 2013 Summary of Decisions - March 2, 2015 - March 6, 2015 Summary of Decisions - March 16, 2015 - March 20

  8. Summary of Decisions - December 31, 2012 - January 4, 2013 | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy 31, 2012 - January 4, 2013 Summary of Decisions - December 31, 2012 - January 4, 2013 January 4, 2013 - 8:38am Addthis No decisions were issued during this week Addthis Related Articles Summary of Decisions - December 24, 2012 - December 28, 2012 Summary of Decisions - January 5, 2015 - January 9, 2015 Summary of Decisions - March 2, 2015 - March 6, 2015

  9. Environmental Impact Assessment Law in China's courts: A study of 107 judicial decisions

    SciTech Connect (OSTI)

    Zining, Jin

    2015-11-15

    The article explores the practices of Environmental Impact Assessment (EIA) Law in China's courts by examining 107 judicial decisions. Each of the 107 judicial decisions has been analyzed to determine the time/location of the decision, what type of EIA document was referred to, what specific claim was made by the plaintiffs, and what the court's ruling was on the case. The results indicate that: unlike in Germany or Japan, all kinds of EIA decisions made by environment protect bureaus (EPBs) in China were widely taken as justiciable, and China's courts generally allowed local residents to have standing and thus challenge the EPBs' decisions made during the EIA process. On the other hand, the research also shows the EPBs overwhelmingly prevailed in those EIA lawsuits. It is also found that China's reviewing judges were highly self-restrained, giving obvious deference to the technocrat with the substantial contents of EIA documents. Also, the concept of “flaw” was created when it came to procedural issues. These two factors, among others, were both helping the EPBs' prevailing successes. - Highlights: • 107 judicial decisions referring to China's EIA law are examined. • The justiciability of EPB's EIA decisions were taken for granted. • The defenders overwhelmingly prevailed in those EIA lawsuits. • The reviewing judges were highly self-restrained, defering to the technocrat with the EIA documents. • A functional concept, “flaw”, was created by reviewing judges when it came to procedural issues.

  10. 5(b)/9(c) Record of Decision

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of the limit. See NRP080005, at 2-3. Evaluation and Decision: BPA acknowledges that a literal reading of the calculation method referenced in Seattle et al.'s comment is...

  11. Decisions that led to Y-12

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Decisions that led to Y-12 Last week we saw the political and organizational changes that led up to the Manhattan Project being created on August 13, 1942. The S-1 Executive ...

  12. Final decisions that led to Y-12

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    decisions that led to Y-12 As we have seen earlier in this series, Ernest O. Lawrence and ... By late 1942, progress on the reactor technology being led by Enrico Fermi at the ...

  13. P:\\DECISION\\0071.tee.wpd

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    number of the decision in the search engine located at http:www.oha.doe.govsearch.htm. ... (firm in bankruptcy); the firm's only employee capable of preparing the report is ill ...

  14. Record of Decision (ROD) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    April 8, 1988 EIS-0113: Record of Decision Disposal of Hanford Defense High-Level, Transuranic, and Tank Wastes, Hanford Site, Richland, Washington May 14, 1981 EIS-0046: Record of...

  15. Record of Decision (ROD) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Revised by State September 25, 2009 EIS-0399: Record of Decision (WAPA) Montana Alberta Tie Ltd. 230-kV Transmission Line Project September 15, 2009 EIS-0312: Record of...

  16. Record of Decision (ROD) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Management December 13, 1996 EIS-0243: Record of Decision (December 1996) Environmental Impact Statement for the Nevada Test Site and Off-Site Locations in the State of Nevada...

  17. Quality Assurance for Critical Decision Reviews RM

    Broader source: Energy.gov [DOE]

    The purpose of this Quality Assurance for Capital Project Critical Decision Review Module (QA RM) is to identify, integrate, and clarify the QA performance objectives, criteria, and guidance needed...

  18. EIS-0217: Supplemental Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Management EIS-0217-ROD-1997.pdf (19.24 KB) More Documents & Publications EIS-0217: Supplemental Record of Decision EIS-0217: Record of Decision EIS-0217: Amended Record of Decision

  19. EIS-0275: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    5: Record of Decision EIS-0275: Record of Decision Disposal of the S1C Prototype Reactor Plant This Record of Decision has been prepared on the proposed disposal of the defueled...

  20. EIS-0377: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0377: Record of Decision Big Stone II Power Plant and Transmission Project Department of Energy announces its record of decision for the Big Stone II Power...

  1. Property:NEPA Decision Url | Open Energy Information

    Open Energy Info (EERE)

    Decision Url Jump to: navigation, search Property Name NEPA Decision Url Property Type URL Description URLs to decisions on NEPA Docs This is a property of type URL. Retrieved from...

  2. EIS-0200: Amendment to the Record of Decision | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Amendment to the Record of Decision EIS-0200: Amendment to the Record of Decision Treatment and Storage of Transuranic Waste Under this amendment to its Record of Decision (ROD),...

  3. Parallel object-oriented decision tree system

    DOE Patents [OSTI]

    Kamath; Chandrika , Cantu-Paz; Erick

    2006-02-28

    A data mining decision tree system that uncovers patterns, associations, anomalies, and other statistically significant structures in data by reading and displaying data files, extracting relevant features for each of the objects, and using a method of recognizing patterns among the objects based upon object features through a decision tree that reads the data, sorts the data if necessary, determines the best manner to split the data into subsets according to some criterion, and splits the data.

  4. Geospatial Decision Making System - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biomass and Biofuels Biomass and Biofuels Find More Like This Return to Search Geospatial Decision Making System Idaho National Laboratory Contact INL About This Technology Technology Marketing Summary The INL has developed a geospatial decision making process to assist agricultural producers in optimizing operating conditions of combine harvesters which detects the presence of grain and distinguishes between that and residual plant material. Upon detecting grain in the process, the system sends

  5. Decision making technical support study for the US Army's Chemical Stockpile Disposal Program

    SciTech Connect (OSTI)

    Feldman, D.L.; Dobson, J.E.

    1990-08-01

    This report examines the adequacy of current command and control systems designed to make timely decisions that would enable sufficient warning and protective response to an accident at the Edgewood area of Aberdeen Proving Ground (APG), Maryland, and at Pine Bluff Arsenal (PBA), Arkansas. Institutional procedures designed to facilitate rapid accident assessment, characterization, warning, notification, and response after the onset of an emergency and computer-assisted decision-making aids designed to provide salient information to on- and-off-post emergency responders are examined. The character of emergency decision making at APG and PBA, as well as potential needs for improvements to decision-making practices, procedures, and automated decision-support systems (ADSSs), are described and recommendations are offered to guide equipment acquisition and improve on- and off-post command and control relationships. We recommend that (1) a continued effort be made to integrate on- and off-post command control, and decision-making procedures to permit rapid decision making; (2) the pathways for alert and notification among on- and off-post officials be improved and that responsibilities and chain of command among off-post agencies be clarified; (3) greater attention be given to organizational and social context factors that affect the adequacy of response and the likelihood that decision-making systems will work as intended; and (4) faster improvements be made to on-post ADSSs being developed at APG and PBA, which hold considerable promise for depicting vast amounts of information. Phased development and procurement of computer-assisted decision-making tools should be undertaken to balance immediate needs against available resources and to ensure flexibility, equity among sites, and compatibility among on- and off-post systems. 112 refs., 6 tabs.

  6. Record of Decision for the Uranium Leasing Program Programmatic...

    Office of Environmental Management (EM)

    Record of Decision for the Uranium Leasing Program Programmatic Environmental Impact Statement Record of Decision for the Uranium Leasing Program Programmatic Environmental Impact ...

  7. Materials Down Select Decisions Made Within DOE's Chemical Hydrogen...

    Office of Environmental Management (EM)

    Down Select Decisions Made Within DOE's Chemical Hydrogen Storage Center of Excellence Materials Down Select Decisions Made Within DOE's Chemical Hydrogen Storage Center of ...

  8. Summary of Decisions - January 5, 2015 - January 9, 2015 | Department...

    Broader source: Energy.gov (indexed) [DOE]

    the noted period. Addthis Related Articles Summary of Decisions - January 13, 2014 - January 17, 2014 Summary of Decisions - May 12, 2014 - May 16, 2014...

  9. DOE Secretarial Memorandum on Improved Decision Making through...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Memorandum on Improved Decision Making through the Integration of Program and Project ... DOE Secretarial Memorandum on Improved Decision Making through the Integration of Program ...

  10. EIS-0374: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0374: Record of Decision Klondike III Biglow Canyon Wind Integration Project The Bonneville Power Administration (BPA) has decided to implement the Proposed...

  11. EIS-0427: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    7: Record of Decision EIS-0427: Record of Decision Interconnection of the Grapevine Canyon Wind Project, Coconino County, Arizona Western Area Power Administration (Western)...

  12. EIS-0345: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0345: Record of Decision Electrical Interconnection of the Plymouth Generating Facility The Bonneville Power Administration (BPA) has decided to implement...

  13. EIS-0413: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    3: Record of Decision EIS-0413: Record of Decision Searchlight Wind Energy Project, Searchlight, NV After considering potential environmental impacts, Western Area Power ...

  14. EIS-0319: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0319: Record of Decision Relocation of Technical Area 18 Capabilities and Materials at the Los Alamos National Laboratory The Department of Energy's (DOE's)...

  15. EIS-0197: Record of Decision (November 1996) | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision (November 1996) EIS-0197: Record of Decision (November 1996) Delivery of the Canadian Entitlement The United States Entity (the Administrator of the Bonneville...

  16. EIS-0372: Record of Decision and Floodplain Statement of Findings...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision and Floodplain Statement of Findings EIS-0372: Record of Decision and Floodplain Statement of Findings Bangor Hydro-Electric Company Northeast Reliability...

  17. EIS-0119: Amended Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    : Amended Record of Decision EIS-0119: Amended Record of Decision Decommissioning of Eight Surplus Production Reactors at the Hanford Site, Richland, Washington DOE has decided to...

  18. EIS-0246: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    : Record of Decision EIS-0246: Record of Decision Wildlife Mitigation Program BPA has decided to adopt the set of prescriptions (goals, strategies, and procedural requirements)...

  19. EIS-0456: Record of Decision and Floodplain Statement of Findings...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision and Floodplain Statement of Findings EIS-0456: Record of Decision and Floodplain Statement of Findings Cushman Hydroelectric Project, Mason County, Washington...

  20. EIS-0230: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    30: Record of Decision EIS-0230: Record of Decision Electrical Interconnection of the Chehalis Generation Facility Bonneville Power Administration (BPA) has decided to offer...

  1. EIS-0343: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0343: Record of Decision Electrical Interconnection of the COB Energy Facility The Bonneville Power Administration (BPA) has decided to offer contract terms...

  2. EIS-0198: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    8: Record of Decision EIS-0198: Record of Decision Uranium Mill Tailings Remedial Action (UMTRA) Ground Water Project (April 1997) The Department of Energy (DOE) is issuing this...

  3. EIS-0330: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0330: Record of Decision Wallula-McNary Transmission Line Project and Wallula Power Project The Bonneville Power Administration (BPA) has decided to...

  4. EIS-0349: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    49: Record of Decision EIS-0349: Record of Decision Electrical Interconnection of the BP Cherry Point Cogeneration Project The Bonneville Power Administration (Bonneville) has...

  5. EIS-0240: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    : Record of Decision EIS-0240: Record of Decision Disposition of Surplus Highly Envirched Uranium The Department of Energy (DOE) has decided to implement a program to make surplus...

  6. EIS-0183: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    in the wholesale power market. PDF icon DOEEIS-0183, Administrator's Record of Decision, Bonneville Power Administration, GNA Cliffs Energy Project, Record of Decision...

  7. EIS-0197: Supplement to Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Supplement to Record of Decision EIS-0197: Supplement to Record of Decision Delivery of the Canadian Entitlement The United States Entity has decided to supplement an earlier...

  8. EIS-0225: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    : Record of Decision EIS-0225: Record of Decision Continued Operation of the Pantex Plant and Associated Storage of Nuclear Weapon Components The Department of Energy is issuing...

  9. EIS-0454: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0454: Record of Decision Tonopah Solar Energy, LLC, Crescent Dunes Solar Energy Project (September 2011) For more information, contact: Ms. Angela Colamaria,...

  10. Decision Support for Operations and Maintenance (DSOM) - Energy...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Decision Support for Operations and Maintenance (DSOM) Pacific Northwest National ... The Decision Support for Operations and Maintenance (DSOM) system is an expert ...

  11. EIS-0082-S2: Record of Decision | Department of Energy

    Energy Savers [EERE]

    Record of Decision EIS-0082-S2: Record of Decision Savannah River Site Salt Processing Alternatives, Aiken, South Carolina The Savannah River Site Salt Processing Alternatives ...

  12. EIS-0440: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    0: Record of Decision EIS-0440: Record of Decision Quartzsite Solar Energy Project, La Paz County, AZ After considering potential environmental impacts, Western Area Power ...

  13. EIS-0161: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Decision Tritium Supply and Recycling The Department of Energy (DOE) is issuing this Record of Decision regarding DOE's proposal for Tritium Supply and Recycling Facilities. ...

  14. EIS-0421: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Decision EIS-0421: Record of Decision Big Eddy-Knight Transmission Project Wasco County, Oregon and Klickitat County, Washington For more information contact: Ms. Stacy Mason,...

  15. EIS-0325: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0325: Record of Decision Schultz-Hanford Area Transmission Line Project Bonneville Power Administration has decided to implement the Agency Preferred...

  16. EIS-0255: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Decision EIS-0255: Record of Decision Execution of Agreements to Install Additional Wind Turbines at the Wyoming Windpower Plant BPA has decided to execute one or more...

  17. EIS-0266: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    6: Record of Decision EIS-0266: Record of Decision Fourmile Hill Geothermal Development Project Power Purchase and Transmission Service Agreements The Bonneville Power...

  18. EIS-0332: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0332: Record of Decision McNary-John Day Transmission Line Project Bonneville Power Administration has decided to implement the proposed action identified in...

  19. Reduction of Transient Particulate Matter Spikes with Decision...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Reduction of Transient Particulate Matter Spikes with Decision Tree Based Control Using a non-parametric decision tree to measure transient PM could correctly identify 94% of high ...

  20. Record of Decision; Defense Waste Processing Facility at the...

    Office of Environmental Management (EM)

    Record of Decision; Defense Waste Processing Facility at the Savannah River Site, Aiken, SC AGENCY: Department of Energy, DOE. ACTION: Record of Decision, Defense Waste Processing ...

  1. EIS-0312: Record of Decision (2012) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Bonneville Power Administration Administrator's Record of Decision: Columbia Basin Fish Accords Memorandum of Agreement (MOA) with the Kalispel Tribe This Record of Decision...

  2. EIS-0397: Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Record of Decision EIS-0397: Record of Decision Lyle Falls Fish Passage Project The Bonneville Power Administration (BPA) has decided to fund modifications to the existing Lyle...

  3. DOE Defends Decision to Revoke Energy Star Designation for Certain...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Decision to Revoke Energy Star Designation for Certain LG Refrigerators DOE Defends Decision to Revoke Energy Star Designation for Certain LG Refrigerators December 23, 2009 -...

  4. Plutonium Record of Decision Statement from NNSA Adminstrator Frank Klotz |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration | (NNSA) Plutonium Record of Decision Statement from NNSA Adminstrator Frank Klotz Plutonium Record of Decision Statement from NNSA Administrator Frank G. Klotz

  5. EIS-0217: Amended Record of Decision | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Amended Record of Decision EIS-0217: Amended Record of Decision Savannah River Site Waste Management, Savannah River Operations Office, Aiken, South Carolina This Record of ...

  6. Plutonium-238 Transuranic Waste Decision Analysis

    SciTech Connect (OSTI)

    Brown, Mike; Lechel, David J.; Leigh, C.D.

    1999-06-29

    Five transuranic (TRU) waste sites in the Department of Energy (DOE) complex, collectively, have more than 2,100 cubic meters of Plutonium-238 (Pu-238) TRU waste that exceed the wattage restrictions of the Transuranic Package Transporter-II (TRUPACT-11). The Waste Isolation Pilot Plant (WIPP) is being developed by the DOE as a repository for TRU waste. With the Waste Isolation Pilot Plant (WIPP) opening in 1999, these sites are faced with a need to develop waste management practices that will enable the transportation of Pu-238 TRU waste to WIPP for disposal. This paper describes a decision analysis that provided a logical framework for addressing the Pu-238 TRU waste issue. The insights that can be gained by performing a formalized decision analysis are multifold. First and foremost, the very process. of formulating a decision tree forces the decision maker into structured, logical thinking where alternatives can be evaluated one against the other using a uniform set of criteria. In the process of developing the decision tree for transportation of Pu-238 TRU waste, several alternatives were eliminated and the logical order for decision making was discovered. Moreover, the key areas of uncertainty for proposed alternatives were identified and quantified. The decision analysis showed that the DOE can employ a combination approach where they will (1) use headspace gas analyses to show that a fraction of the Pu-238 TRU waste drums are no longer generating hydrogen gas and can be shipped to WIPP ''as-is'', (2) use drums and bags with advanced filter systems to repackage Pu-238 TRU waste drums that are still generating hydrogen, and (3) add hydrogen getter materials to the inner containment vessel of the TRUPACT-11to relieve the build-up of hydrogen gas during transportation of the Pu-238 TRU waste drums.

  7. A Multiple Objective Decision Support Tool (MODS)

    Energy Science and Technology Software Center (OSTI)

    2003-12-14

    The Multiple Objective Decision Support (MODS) tool is an automated tool used to assist decision makers and policy analysts with multiple-objective decision problems. The classes of problems that this decision support tool addresses have both multiple objectives and multiple stakeholders. Decision problems, which have multiple objectives that in general cannot be maximized simultaneously, and multiple stakeholders, who have different perspectives about the relative importance of the objectives, require analytic approaches and tools that can providemore » flexible support to decision makers. This tool provides capabilities for the management, analysis, and graphical display for these types of decision problems drawn from diverse problem domains. The MODS tool is a unique integration of analysis algorithms, an information database, and a graphical user interface. This collection of algorithms, the combination of an information database with the analysis into a single tool, and the graphical user interface provides a technically advanced tool to decision makers and policy analysts. There are two main issues when addressing problems of this type: what set of attributes should be used to characterize the tokens in the domain of interest, and how should the values of these attributes and their weights be determined and combined to provide a relative ordering to the tokens. This tool addresses both of these issues. This decision support tool provides a flexible way to derive and use a chosen set of attributes. For example, the tool could be used to first perform a paired comparison of a large set of attributes and from this evaluation select those attributes that have the highest weights. The flexibility of the tool allows experimentation with various attribute sets and this capability, along with domain expertise, addresses the first issue. To address the second issue, several algorithms have been implemented. For example, two algorithms that have been implemented are

  8. Insulin-Like Growth Factor-Type 1 Receptor Inhibitor NVP-AEW541 Enhances Radiosensitivity of PTEN Wild-Type but Not PTEN-Deficient Human Prostate Cancer Cells

    SciTech Connect (OSTI)

    Isebaert, Sofie F.; Swinnen, Johannes V.; McBride, William H.; Haustermans, Karin M.

    2011-09-01

    Purpose: During the past decade, many clinical trials with both monoclonal antibodies and small molecules that target the insulin-like growth factor-type 1 receptor (IGF-1R) have been launched. Despite the important role of IGF-1R signaling in radioresistance, studies of such agents in combination with radiotherapy are lagging behind. Therefore, the aim of this study was to investigate the effect of the small molecule IGF-1R kinase inhibitor NVP-AEW541 on the intrinsic radioresistance of prostate cancer cells. Methods and Materials: The effect of NVP-AEW541 on cell proliferation, cell viability, IGF-1R signaling, radiosensitivity, cell cycle distribution, and double strand break repair was determined in three human prostate cancer cell lines (PC3, DU145, 22Rv1). Moreover, the importance of the PTEN pathway status was explored by means of transfection experiments with constitutively active Akt or inactive kinase-dead Akt. Results: NVP-AEW541 inhibited cell proliferation and decreased cell viability in a time-and dose-dependent manner in all three cell lines. Radiosensitization was observed in the PTEN wild-type cell lines DU145 and 22Rv1 but not in the PTEN-deficient PC3 cell line. NVP-AEW541-induced radiosensitization coincided with downregulation of phospho-Akt levels and high levels of residual double strand breaks. The importance of PTEN status in the radiosensitization effect was confirmed by transfection experiments with constitutively active Akt or inactive kinase-dead Akt. Conclusions: NVP-AEW541 enhances the effect of ionizing radiation in PTEN wild-type, but not in PTEN-deficient, prostate cancer cells. Proper patient selection based on the PTEN status of the tumor will be critical to the achievement of optimal results in clinical trials in which the combination of radiotherapy and this IGF-1R inhibitor is being explored.

  9. Summary of Decisions- August 19, 2013- August 23, 2013

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)

  10. Summary of Decisions- July 30 – August 3, 2012

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)

  11. Summary of Decisions- April 4, 2016 – April 8, 2016

    Office of Energy Efficiency and Renewable Energy (EERE)

    Decisions were issued on: - Personnel Security (10 CFR Part 710) - Freedom of Information Act Appeal

  12. Summary of Decisions- August 5, 2013- August 9, 2013

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Personnel Security (10 CFR Part 710) - Whistleblower Appeal (10 CFR Part 708)

  13. Summary of Decisions- October 6, 2014 – October 10, 2014

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Personnel Security (10 CFR Part 710) - Freedom of Information Act Appeal

  14. Summary of Decisions- March 10, 2014 – March 14, 2014

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)

  15. Summary of Decisions- July 21, 2014 – July 25, 2014

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)

  16. Summary of Decisions- April 1, 2013 – April 5, 2013

    Office of Energy Efficiency and Renewable Energy (EERE)

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)

  17. Summary of Decisions- January 21, 2013 – January 25, 2013

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)

  18. Summary of Decisions- April 7, 2014 – April 11, 2014

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)

  19. Summary of Decisions- October 21, 2013 – October 25, 2013

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)

  20. Summary of Decisions- February 9, 2015 – February 13, 2015

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Personnel Security (10 CFR Part 710) - Freedom of Information Act Appeal

  1. Summary of Decisions- January 20, 2014 – January 24, 2014

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)

  2. Summary of Decisions- July 14, 2014 – July 18, 2014

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)

  3. Summary of Decisions- July 22, 2013- July 26, 2013

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Freedom of Information Act Appeal - Personnel Security (10 CFR Part 710)

  4. Summary of Decisions- April 8, 2013 – April 12, 2013

    Office of Energy Efficiency and Renewable Energy (EERE)

    Decisions were issued on: - Freedom of Information Act Appeal - Whistleblower Appeal (10 CFR Part 708)

  5. Summary of Decisions- June 8, 2015 – June 12, 2015

    Office of Energy Efficiency and Renewable Energy (EERE)

    Decisions were issued on: - Personnel Security (10 CFR Part 710) - Freedom of Information Act Appeal

  6. Summary of Decisions- December 21, 2015 – December 25, 2015

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Personnel Security (10 CFR Part 710) - Freedom of Information Act Appeal

  7. Summary of Decisions- November 16, 2015 – November 20, 2015

    Broader source: Energy.gov [DOE]

    Decisions were issued on: - Personnel Security (10 CFR Part 710) - Freedom of Information Act Appeal

  8. Summary of Decisions- August 17, 2015 – August 21, 2015

    Office of Energy Efficiency and Renewable Energy (EERE)

    Decisions were issued on: - Personnel Security (10 CFR Part 710) - Freedom of Information Act Appeal

  9. Summary of Decisions- November 30, 2015 – December 4, 2015

    Office of Energy Efficiency and Renewable Energy (EERE)

    Decisions were issued on: - Personnel Security (10 CFR Part 710) - Freedom of Information Act Appeal

  10. Summary of Decisions- September 21, 2015 – September 25, 2015

    Office of Energy Efficiency and Renewable Energy (EERE)

    Decisions were issued on: - Personnel Security (10 CFR Part 710) - Freedom of Information Act Appeal