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Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic...

2

Aging and Fracture of Human Cortical Bone and Tooth Dentin  

SciTech Connect (OSTI)

Mineralized tissues, such as bone and tooth dentin, serve as structural materials in the human body and, as such, have evolved to resist fracture. In assessing their quantitative fracture resistance or toughness, it is important to distinguish between intrinsic toughening mechanisms which function ahead of the crack tip, such as plasticity in metals, and extrinsic mechanisms which function primarily behind the tip, such as crack bridging in ceramics. Bone and dentin derive their resistance to fracture principally from extrinsic toughening mechanisms which have their origins in the hierarchical microstructure of these mineralized tissues. Experimentally, quantification of these toughening mechanisms requires a crack-growth resistance approach, which can be achieved by measuring the crack-driving force, e.g., the stress intensity, as a function of crack extension ("R-curve approach"). Here this methodology is used to study of the effect of aging on the fracture properties of human cortical bone and human dentin in order to discern the microstructural origins of toughness in these materials.

Ager, Joel; Koester, Kurt J.; Ager III, Joel W.; Ritchie, Robert O.

2008-05-07T23:59:59.000Z

3

Mixed-mode fracture of human cortical bone Elizabeth A. Zimmermann a,b  

E-Print Network [OSTI]

Mixed-mode fracture of human cortical bone Elizabeth A. Zimmermann a,b , Maximilien E. Launey Available online 1 July 2009 Keywords: Human cortical bone Mixed-mode fracture Fracture toughness Fracture mechanisms a b s t r a c t Although the mode I (tensile opening) fracture toughness has been the focus

Ritchie, Robert

4

Fracture resistance of human cortical bone across multiple length-scales at physiological strain rates  

E-Print Network [OSTI]

Fracture resistance of human cortical bone across multiple length-scales at physiological strain Accepted 22 March 2014 Available online 13 April 2014 Keywords: Bone Strain rate Fracture toughness Plasticity X-ray diffraction a b s t r a c t While most fracture-mechanics investigations on bone have been

Ritchie, Robert

5

Journal of Biomechanics 38 (2005) 15171525 Fracture in human cortical bone: local fracture criteria and  

E-Print Network [OSTI]

Journal of Biomechanics 38 (2005) 1517­1525 Fracture in human cortical bone: local fracture, Livermore, CA 94550 Accepted 19 July 2004 Abstract Micromechanical models for fracture initiation such micromechanical models have been developed for the fracture of bone. In fact, although the fracture event

Ritchie, Robert O.

6

Aging and Fracture of Human Cortical Bone and Tooth Dentin  

E-Print Network [OSTI]

Mechanistic aspects of fracture and R-curve behavior inof failure of solid biomaterials and bone: `fracture' and `pre- fracture' toughness. Materials Science and Engineering:

Ager III, Joel W.

2008-01-01T23:59:59.000Z

7

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfrared LandResponsesIon/Surface ReactionsIrradiation Effects on Human

8

On the effect of x-ray irradiation on the deformation and fracture behavior of human cortical bone  

SciTech Connect (OSTI)

In situ mechanical testing coupled with imaging using high-energy synchrotron x-ray diffraction or tomography imaging is gaining in popularity as a technique to investigate micrometer and even sub-micrometer deformation and fracture mechanisms in mineralized tissues, such as bone and teeth. However, the role of the irradiation in affecting the nature and properties of the tissue is not always taken into account. Accordingly, we examine here the effect of x-ray synchrotron-source irradiation on the mechanistic aspects of deformation and fracture in human cortical bone. Specifically, the strength, ductility and fracture resistance (both work-of-fracture and resistance-curve fracture toughness) of human femoral bone in the transverse (breaking) orientation were evaluated following exposures to 0.05, 70, 210 and 630 kGy irradiation. Our results show that the radiation typically used in tomography imaging can have a major and deleterious impact on the strength, post-yield behavior and fracture toughness of cortical bone, with the severity of the effect progressively increasing with higher doses of radiation. Plasticity was essentially suppressed after as little as 70 kGy of radiation; the fracture toughness was decreased by a factor of five after 210 kGy of radiation. Mechanistically, the irradiation was found to alter the salient toughening mechanisms, manifest by the progressive elimination of the bone's capacity for plastic deformation which restricts the intrinsic toughening from the formation 'plastic zones' around crack-like defects. Deep-ultraviolet Raman spectroscopy indicated that this behavior could be related to degradation in the collagen integrity.

Barth, Holly D.; Launey, Maximilien E.; McDowell, Alastair A.; Ager III, Joel W.; Ritchie, Robert O.

2010-01-10T23:59:59.000Z

9

Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone  

SciTech Connect (OSTI)

Bone comprises a complex structure of primarily collagen, hydroxyapatite and water, where each hierarchical structural level contributes to its strength, ductility and toughness. These properties, however, are degraded by irradiation, arising from medical therapy or bone-allograft sterilization. We provide here a mechanistic framework for how irradiation affects the nature and properties of human cortical bone over a range of characteristic (nano to macro) length-scales, following x-­ray exposures up to 630 kGy. Macroscopically, bone strength, ductility and fracture resistance are seen to be progressively degraded with increasing irradiation levels. At the micron-­scale, fracture properties, evaluated using in-situ scanning electron microscopy and synchrotron x-ray computed micro-tomography, provide mechanistic information on how cracks interact with the bone-matrix structure. At sub-micron scales, strength properties are evaluated with in-situ tensile tests in the synchrotron using small-/wide-angle x-ray scattering/diffraction, where strains are simultaneously measured in the macroscopic tissue, collagen fibrils and mineral. Compared to healthy bone, results show that the fibrillar strain is decreased by ~40% following 70 kGy exposures, consistent with significant stiffening and degradation of the collagen. We attribute the irradiation-­induced deterioration in mechanical properties to mechanisms at multiple length-scales, including changes in crack paths at micron-­scales, loss of plasticity from suppressed fibrillar sliding at sub-­micron scales, and the loss and damage of collagen at the nano-­scales, the latter being assessed using Raman and Fourier-Transform-Infrared spectroscopy and a fluorometric assay.

Barth, Holly; Zimmermann, Elizabeth; Schaible, Eric; Tang, Simon; Alliston, Tamara; Ritchie, Robert

2011-08-19T23:59:59.000Z

10

Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone  

E-Print Network [OSTI]

in   bone   strength.   Osteoporosis  Int    2006;17:319-­??fragility   in   aging,   osteoporosis,   and   diabetes  mellitus.  Osteoporosis  Int    2010;21:195-­??214.  

Barth, Holly

2012-01-01T23:59:59.000Z

11

CORTICAL BONE FRACTURE R. O. RITCHIE  

E-Print Network [OSTI]

with menopause in aging women, can lead to osteoporosis, a condition of low bone mass associated the therapeutic benefits of antiresorptive agents in treating osteoporosis (6,7) has re-emphasized the ne- cessity

Ritchie, Robert

12

autogenous cortical bone: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cortical systems for local and global integration in discourse comprehension Giovanna Egidi a, Biology and Medicine Websites Summary: Cortical systems for local and global...

13

autopod cortical bone: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cortical systems for local and global integration in discourse comprehension Giovanna Egidi a, Biology and Medicine Websites Summary: Cortical systems for local and global...

14

Effect of cryo-induced microcracks on microindentation of hydrated cortical bone tissue  

SciTech Connect (OSTI)

Microcracks accumulate in cortical bone tissue as a consequence of everyday cyclic loading. However, it remains unclear to what extent microdamage accumulation contributes to an increase in fracture risk. A cryo-preparation technique was applied to induce microcracks in cortical bone tissue. Microcracks with lengths up to approximately 20 {mu}m, which were initiated mainly on the boundaries of haversian canals, were observed with cryo-scanning electron microscopy. A microindentation technique was applied to study the mechanical loading effect on the microcracked hydrated bone tissue. The microindentation patterns were section-scanned using confocal laser scanning microscopy to understand the deformation and bone damage mechanisms made by mechanical loading. The results show that there was no significant difference with respect to microhardness between the original and microcracked hydrated cortical bone tissues (ANOVA, p > 0.05). The cryo-induced microcracks in the bone tissue were not propagated further under the mechanical loads applied. The deformation mechanism of the microcracked cortical bone tissue was plastic deformation, not brittle fracture.

Yin Ling, E-mail: ling.yin@jcu.edu.au [School of Engineering, James Cook University, Townsville, QLD 4811 (Australia); Venkatesan, Sudharshan [Department of Engineering, Australian National University, Canberra, ACT 0200 Australia (Australia); Webb, Daryl [Electron Microscopy Unit, Australian National University, Canberra, ACT 0200 (Australia); Kalyanasundaram, Shankar; Qin Qinghua [Department of Engineering, Australian National University, Canberra, ACT 0200 Australia (Australia)

2009-08-15T23:59:59.000Z

15

Children cortical bone characterisation: the ultrasonic J.-P. Berteaua  

E-Print Network [OSTI]

infantile osteo-pathologies. That is why there is a strong interest in the characterisation of the growing specific location (close to cancerous cells) or cadaveric bone. They indicate a lower Young's modulus

Boyer, Edmond

16

The effect of excitation and preparation pulses on nonslice selective 2D UTE bicomponent analysis of bound and free water in cortical bone at 3T  

SciTech Connect (OSTI)

Purpose: The purpose of this study was to investigate the effect of excitation, fat saturation, long T2 saturation, and adiabatic inversion pulses on ultrashort echo time (UTE) imaging with bicomponent analysis of bound and free water in cortical bone for potential applications in osteoporosis. Methods: Six bovine cortical bones and six human tibial midshaft samples were harvested for this study. Each bone sample was imaged with eight sequences using 2D UTE imaging at 3T with half and hard excitation pulses, without and with fat saturation, long T2 saturation, and adiabatic inversion recovery (IR) preparation pulses. Single- and bicomponent signal models were utilized to calculate the T2{sup *}s and/or relative fractions of short and long T2{sup *}s. Results: For all bone samples UTE T2{sup *} signal decay showed bicomponent behavior. A higher short T2{sup *} fraction was observed on UTE images with hard pulse excitation compared with half pulse excitation (75.6% vs 68.8% in bovine bone, 79.9% vs 73.2% in human bone). Fat saturation pulses slightly reduced the short T2{sup *} fraction relative to regular UTE sequences (5.0% and 2.0% reduction, respectively, with half and hard excitation pulses for bovine bone, 6.3% and 8.2% reduction, respectively, with half and hard excitation pulses for human bone). Long T2 saturation pulses significantly reduced the long T2{sup *} fraction relative to regular UTE sequence (18.9% and 17.2% reduction, respectively, with half and hard excitation pulses for bovine bone, 26.4% and 27.7% reduction, respectively, with half and hard excitation pulses for human bone). With IR-UTE preparation the long T2{sup *} components were significantly reduced relative to regular UTE sequence (75.3% and 66.4% reduction, respectively, with half and hard excitation pulses for bovine bone, 87.7% and 90.3% reduction, respectively, with half and hard excitation pulses for human bone). Conclusions: Bound and free water T2{sup *}s and relative fractions can be assessed using UTE bicomponent analysis. Long T2{sup *} components are affected more by long T2 saturation and IR pulses, and short T2{sup *} components are affected more by fat saturation pulses.

Li, Shihong [Department of Radiology, University of California, San Diego, California 92103-8226 (United States) [Department of Radiology, University of California, San Diego, California 92103-8226 (United States); Department of Radiology, Hua Dong Hospital, Fudan University, Shanghai 200040 (China); Yancheng Medical College, Jiangsu (China); The First People's Hospital of Yancheng City, Jiangsu 224005 (China); Chang, Eric Y.; Chung, Christine B. [VA San Diego Healthcare System, San Diego, California 92161 and Department of Radiology, University of California, San Diego, California 92103-8226 (United States)] [VA San Diego Healthcare System, San Diego, California 92161 and Department of Radiology, University of California, San Diego, California 92103-8226 (United States); Bae, Won C.; Du, Jiang, E-mail: jiangdu@ucsd.edu [Department of Radiology, University of California, San Diego, California 92103-8226 (United States)] [Department of Radiology, University of California, San Diego, California 92103-8226 (United States); Hua, Yanqing [Department of Radiology, Hua Dong Hospital, Fudan University, Shanghai 200040 (China)] [Department of Radiology, Hua Dong Hospital, Fudan University, Shanghai 200040 (China); Zhou, Yi [The First People's Hospital of Yancheng City, Jiangsu 224005 (China)] [The First People's Hospital of Yancheng City, Jiangsu 224005 (China)

2014-02-15T23:59:59.000Z

17

A representation of changing heading direction in human cortical areas pVIP and CSv  

E-Print Network [OSTI]

Running title: Changing heading direction in the human brain Keywords: egomotion; f1 A representation of changing heading direction in human cortical in the environment, we continually change direction. Much work has examined how the brain

Royal Holloway, University of London

18

Structural Analysis of Human and Bovine Bone for Development of Synthetic Materials  

E-Print Network [OSTI]

bones, as well as mimicking nature by developing a synthetic material to repair bones. Experimentally, bovine bone, tumor-free human bone, and cancerous human bone were studied via the small scale mechanical loading test. Failure analysis was conducted...

Jang, Eunhwa

2012-10-19T23:59:59.000Z

19

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickrinformation for andFuel-Efficient Engines |Iron is the Key toIron

20

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickrinformation for andFuel-Efficient Engines |Iron is the Key

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfrared LandResponsesIon/Surface ReactionsIrradiation Effects on

22

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfrared LandResponsesIon/Surface ReactionsIrradiation Effects onIrradiation

23

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfrared LandResponsesIon/Surface ReactionsIrradiation Effects

24

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfrared LandResponsesIon/Surface ReactionsIrradiation EffectsIrradiation

25

In Vivo Evaluation of the Presence of Bone Marrow in Cortical Porosity in Postmenopausal Osteopenic Women  

E-Print Network [OSTI]

bone resorption in osteoporosis. Calcif. Tissue Int. Augat,Porosity in Women with Osteoporosis. Vienna, Austria:porosity in women with osteoporosis. J. Bone Miner. Res.

Goldenstein, Janet; Kazakia, Galateia; Majumdar, Sharmila

2010-01-01T23:59:59.000Z

26

ancient human bones: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Reich, David 159 OsteoConduct: Wireless Body-Area Communication based on Bone Conduction Energy Storage, Conversion and Utilization Websites Summary: , Measurement, Human Factors....

27

Accounting for beta-particle energy loss to cortical bone via paired-image radiation transport (PIRT)  

SciTech Connect (OSTI)

Current methods of skeletal dose assessment in both medical physics (radionuclide therapy) and health physics (dose reconstruction and risk assessment) rely heavily on a single set of bone and marrow cavity chord-length distributions in which particle energy deposition is tracked within an infinite extent of trabecular spongiosa, with no allowance for particle escape to cortical bone. In the present study, we introduce a paired-image radiation transport (PIRT) model which provides a more realistic three-dimensional (3D) geometry for particle transport in the skeletal site at both microscopic and macroscopic levels of its histology. Ex vivo CT scans were acquired of the pelvis, cranial cap, and individual ribs excised from a 66-year male cadaver (BMI of 22.7 kg m{sup -2}). For the three skeletal sites, regions of trabecular spongiosa and cortical bone were identified and segmented. Physical sections of interior spongiosa were taken and subjected to microCT imaging. Voxels within the resulting microCT images were then segmented and labeled as regions of bone trabeculae, endosteum, active marrow, and inactive marrow through application of image processing algorithms. The PIRT methodology was then implemented within the EGSNRC radiation transport code whereby electrons of various initial energies are simultaneously tracked within both the ex vivo CT macroimage and the CT microimage of the skeletal site. At initial electron energies greater than 50-200 keV, a divergence in absorbed fractions to active marrow are noted between PIRT model simulations and those estimated under existing techniques of infinite spongiosa transport. Calculations of radionuclide S values under both methodologies imply that current chord-based models may overestimate the absorbed dose to active bone marrow in these skeletal sites by 0% to 27% for low-energy beta emitters ({sup 33}P, {sup 169}Er, and {sup 177}Lu), by {approx}4% to 49% for intermediate-energy beta emitters ({sup 153}Sm, {sup 186}Re, and {sup 89}Sr), and by {approx}14% to 76% for high-energy beta emitters ({sup 32}P, {sup 188}Re, and {sup 90}Y). The PIRT methodology allows for detailed modeling of the 3D macrostructure of individual marrow-containing bones within the skeleton thus permitting improved estimates of absorbed fractions and radionuclide S values for intermediate-to-high energy beta emitters.

Shah, Amish P.; Rajon, Didier A.; Patton, Phillip W.; Jokisch, Derek W.; Bolch, Wesley E. [Department of Biomedical Engineering and Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida 32611 (United States); Deparment of Neurosurgery, University of Florida, Gainesville, Florida 32611 (United States); Department of Health Physics, University of Nevada-Las Vegas, Las Vegas, Nevada (United States); Department of Physics and Astronomy, Francis Marion University, Florence, South Carolina 29501-0547 (United States); Department of Biomedical Engineering and Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida 32611 (United States)

2005-05-01T23:59:59.000Z

28

Methods for testing the strength of cancellous bone and tested method effects on cortical bone in the ovariectomized rat  

E-Print Network [OSTI]

In this study, two mechanical testing procedures were developed to test the strength of cancellous bone from the proximal tibia of the rat, the "punch method" and the "whole slice method". These were used to quantify the effect of ovariectomy on rat...

Ruhmann, Sean Phillip

1998-01-01T23:59:59.000Z

29

r Human Brain Mapping 32:382396 (2011) r CENTS: Cortical Enhanced Neonatal Tissue  

E-Print Network [OSTI]

r Human Brain Mapping 32:382­396 (2011) r CENTS: Cortical Enhanced Neonatal Tissue Segmentation-quality magnetic resonance (MR) images of neonatal brains is largely ham- pered by their characteristically small head size and insufficient tissue contrast. As a result, subsequent image processing and analysis

Utah, University of

2011-01-01T23:59:59.000Z

30

Differential Maintenance of Cortical and Cancellous Bone Strength Following Discontinuation of  

E-Print Network [OSTI]

and with combination of osteoporosis medications are needed to improve our treatment of osteoporosis. ß 2011 American; RALOXIFENE Introduction A number of drugs offer some protection against post- menopausal bone loss and nonvertebral fractures in postmenopausal osteoporosis.(3) While bisphosphonates such as ALN may accumulate

Ritchie, Robert

31

The bending and dynamic mechanical properties of cortical bone: the effects of sodium fluoride and the relationship to physical properties  

E-Print Network [OSTI]

Bone is a complex organic composite material. The graphics. interface between the mineral and organic phases of bone is significant both to medicine and to the biokinetics, a field which seeks to create advanced synthetic materials by copying...

McCurdy-Rahn, Megan Calista

1998-01-01T23:59:59.000Z

32

Stability of muscle synergies for voluntary actions after cortical stroke in humans  

E-Print Network [OSTI]

Production of voluntary movements relies critically on the functional integration of several motor cortical areas, such as the primary motor cortex, and the spinal circuitries. Surprisingly, after almost 40 years of research, ...

Bizzi, Emilio

33

The petrous portion of the human temporal bone: potential for forensic individuation  

E-Print Network [OSTI]

are threefold: (1) To investigate variability in the shape of the petrous portion of the human temporal bone using two-dimensional morphometric analysis; (2) to evaluate the reliability of the resultant method in forensic identification; and (3) to consider...

Wiersema, Jason Matthew

2009-06-02T23:59:59.000Z

34

Neural correlates of auditory perceptual organization measured with direct cortical recordings in humans  

E-Print Network [OSTI]

One of the primary functions of the human auditory system is to separate the complex mixture of sound arriving at the ears into neural representations of individual sound sources. This function is thought to be crucial for ...

Dykstra, Andrew R. (Andrew Richard)

2011-01-01T23:59:59.000Z

35

Nanomechanics and ultrastructural studies of cortical bone : fundamental insights regarding structure-function, mineral-organic force mechanics interactions, and heterogeneity  

E-Print Network [OSTI]

Although the mechanics of bone has been studied extensively at the micro- and macro-scale, the nano-scopic level is perhaps the most illuminating as this is the length scale at which the individual constituents interact. ...

Tai, Kuangshin

2007-01-01T23:59:59.000Z

36

Endocortical bone loss in osteoporosis: the role of bone surface availability  

E-Print Network [OSTI]

Age-related bone loss and postmenopausal osteoporosis are disorders of bone remodelling, in which less bone is reformed than resorbed. Yet, this dysregulation of bone remodelling does not occur equally in all bone regions. Loss of bone is more pronounced near the endocortex, leading to cortical wall thinning and medullary cavity expansion, a process sometimes referred to as "trabecularisation" or "cancellisation". Cortical wall thinning is of primary concern in osteoporosis due to the strong reduction in bone mechanical properties that it is associated with. In this paper, we examine the possibility that the nonuniformity of microscopic bone surface availability could explain the nonuniformity of bone loss in osteoporosis. We use a simple computational model of bone remodelling, in which microscopic bone surface availability influences bone turnover rate, to simulate the evolution of the bone volume fraction profile across the midshaft of a long bone. We find that bone loss is accelerated near the endocortica...

Buenzli, Pascal R; Clement, John G; Pivonka, Peter

2012-01-01T23:59:59.000Z

37

E-Print Network 3.0 - abnormal cortical asymmetry Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

search results for: abnormal cortical asymmetry Page: << < 1 2 3 4 5 > >> 1 Human Brain Mapping 2008 Conference Abstract Number 438 Detection of Local Cortical Asymmetry via...

38

A multiscale mechanobiological model of bone remodelling predicts site-specific bone loss in the femur during osteoporosis and mechanical disuse  

E-Print Network [OSTI]

We propose a multiscale mechanobiological model of bone remodelling to investigate the site-specific evolution of bone volume fraction across the midshaft of a femur. The model includes hormonal regulation and biochemical coupling of bone cell populations, the influence of the microstructure on bone turnover rate, and mechanical adaptation of the tissue. Both microscopic and tissue-scale stress/strain states of the tissue are calculated from macroscopic loads by a combination of beam theory and micromechanical homogenisation. This model is applied to simulate the spatio-temporal evolution of a human midshaft femur scan subjected to two deregulating circumstances: (i) osteoporosis and (ii) mechanical disuse. Both simulated deregulations led to endocortical bone loss, cortical wall thinning and expansion of the medullary cavity, in accordance with experimental findings. Our model suggests that these observations are attributable to a large extent to the influence of the microstructure on bone turnover rate. Mec...

Lerebours, C; Scheiner, S; Pivonka, P

2015-01-01T23:59:59.000Z

39

Human {beta}-globin gene polymorphisms characterized in DNA extracted from ancient bones 12,000 years old  

SciTech Connect (OSTI)

Analyzing the nuclear DNA from ancient human bones is an essential step to the understanding of genetic diversity in current populations, provided that such systematic studies are experimentally feasible. This article reports the successful extraction and amplification of nuclear DNA from the P-globin region from 5 of 10 bone specimens up to 12,000 years old. These have been typed for P-globin frameworks by sequencing through two variable positions and for a polymorphic (AT){sub x}(T){sub y} microsatellite 500 bp upstream of the P-globin gene. These specimens of human remains are somewhat older than those analyzed in previous nuclear gene sequencing reports and considerably older than those used to study high-copy-number human mtDNA. These results show that the systematic study of nuclear DNA polymorphisms of ancient populations is feasible. 34 refs., 3 figs., 2 tabs.

Beraud-Colomb, E. [Genetique Medicale et Developpement, Marseille (France)]|[Laboratoire d`Anthropologie, Marseille (France); Maroc, N. [Genetique Medicale et Developpement, Marseille (France); Roubin, R. [Institut Paoli-Calmettes, Marseille (France)] [and others

1995-12-01T23:59:59.000Z

40

DU145 human prostate cancer cells express functional Receptor Activator of NF-B: New insights in the prostate cancer bone metastasis process.  

E-Print Network [OSTI]

1 DU145 human prostate cancer cells express functional Receptor Activator of NF-B: New insights in the prostate cancer bone metastasis process. Mori K.1, 2, * , Le Goff B. 1, 2 , Charrier C. 1, 2 , Battaglia S;40(4):981-90" DOI : 10.1016/j.bone.2006.11.006 #12;2 Abstract Prostate cancer metastases to bone are observed

Boyer, Edmond

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Journal of Biomechanics 41 (2008) 10621068 Nonlinear ultrasound can detect accumulated damage in human bone  

E-Print Network [OSTI]

due to the fact that osteoporosis and bone fragility are increasingly widespread diseases. Fracture increases exponentially with age, with a significant increase corresponding to the beginning of menopause

2008-01-01T23:59:59.000Z

42

Modeling cortical circuits.  

SciTech Connect (OSTI)

The neocortex is perhaps the highest region of the human brain, where audio and visual perception takes place along with many important cognitive functions. An important research goal is to describe the mechanisms implemented by the neocortex. There is an apparent regularity in the structure of the neocortex [Brodmann 1909, Mountcastle 1957] which may help simplify this task. The work reported here addresses the problem of how to describe the putative repeated units ('cortical circuits') in a manner that is easily understood and manipulated, with the long-term goal of developing a mathematical and algorithmic description of their function. The approach is to reduce each algorithm to an enhanced perceptron-like structure and describe its computation using difference equations. We organize this algorithmic processing into larger structures based on physiological observations, and implement key modeling concepts in software which runs on parallel computing hardware.

Rohrer, Brandon Robinson; Rothganger, Fredrick H.; Verzi, Stephen J.; Xavier, Patrick Gordon

2010-09-01T23:59:59.000Z

43

High-speed photography of compressed human trabecular bone correlates whitening to microscopic damage  

E-Print Network [OSTI]

of trabecular bone is mainly motivated by the huge impact of osteoporosis in post-menopausal women and the aged is mainly motivated by the reduction of bone strength due to osteoporosis, a systemic skeletal disease [10.elsevier.com/locate/engfracmech #12;comes with a concomitant increase of fracture risk. Post-menopausal women and the elderly

Fygenson, Deborah Kuchnir

44

High-Speed Photography of Human Trabecular Bone during Compression Philipp J. Thurner1  

E-Print Network [OSTI]

of this research is motivated by the immense costs of health care and social impacts due to osteoporosis in post-menopausal women and the aged. Osteoporosis results in bone loss and change of trabecular architecture, causing of osteoporosis, a systemic, skeletal disease2 , which comes with a reduction of bone strength and a concomitant

Fygenson, Deborah Kuchnir

45

Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions  

DOE Patents [OSTI]

The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients.

Srivastava, Suresh C. (Setauket, NY); Meinken, George E. (Middle Island, NY); Mausner, Leonard F. (Stony Brook, NY); Atkins, Harold L. (Setauket, NY)

1998-12-29T23:59:59.000Z

46

Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions  

DOE Patents [OSTI]

The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients. 5 figs.

Srivastava, S.C.; Meinken, G.E.; Mausner, L.F.; Atkins, H.L.

1998-12-29T23:59:59.000Z

47

A new anthropometric phantom for calibrating in vivo measurements of stable lead in the human leg using X-ray fluorescence  

SciTech Connect (OSTI)

A new anthropometric phantom has been developed for calibrating in vivo measurements of stable lead deposited in bone using x-ray fluorescence. The phantom reproduces the shape of the mid shaft of the adult human leg and is fabricated using polyurethanes and calcium carbonate to produce materials that exhibit the same density, energy transmission, and calcium content as cortical bone, bone marrow, and muscle. The phantom includes a removable tibia fabricated using simulants for cortical bone and bone marrow to which a precise amount of stable lead has been added to cortical bone. The formulations used in fabricating the new anthropometric phantom are much more uniform in density and composition than the conventional phantom made from Plexiglas cylinders filled with plaster-of-Paris. The energy spectrum from an x-ray fluorescence measurement of the phantom using a {sup 109}Cd source is indistinguishable from an in vivo x-ray fluorescence measurement of the human leg, demonstrating that the materials used in the phantom exhibit the same radiological properties as human tissue. Likewise, results from x-ray fluorescence measurements of the phantom exhibit the same positional dependency as the human leg and vary by approximately 36% when, for example, the phantom containing 54 ppm of stable lead in the tibia was rotated by only 15 degrees. The detection limit for a 30 min {sup 109}Cd K shell x-ray fluorescence in vivo measurement is approximately 20 ppm determined from a background measurement using the new phantom containing no added lead in the muscle, bone, or bone marrow. The new anthropometric phantom significantly improves in vivo x-ray fluorescence calibration measurements by (1) faithfully reproducing the anatomy of the human leg, (2) having components that exhibit radiological properties similar to that of human tissue, and (3) providing a realistic calibration standard that can be used for in vivo x-ray fluorescence intercomparison measurements.

Spitz, H.; Jenkins, M.; Lodwick, J.; Bornschein, R.

2000-02-01T23:59:59.000Z

48

Temperature Measurement During Polymerization of Bone Cement in Percutaneous Vertebroplasty: An In Vivo Study in Humans  

SciTech Connect (OSTI)

Aim of the study was to 'in vivo' measure temperature, during percutaneous vertebroplasty (PV), within a vertebral body injected with different bone cements. According to the declaration of Helsinki, 22 women (60-80 years; mean, 75 years) with painful osteoporotic vertebral collapse underwent bilateral transpedicular PV on 22 lumbar vertebrae. Two 10-G vertebroplasty needles were introduced into the vertebra under digital fluoroscopy; a 16-G radiofrequency thermoablation needle (Starburst XL; RITA Medical System Inc., USA), carrying five thermocouples, was than coaxially inserted. Eleven different bone cements were injected and temperatures were measured every 30 s until temperatures dropped under 45{sup o}C. After the thermocouple needle was withdrawn, bilateral PV was completed with cement injection through the vertebroplasty needle. Unpaired Student's t-tests, Kruskal-Wallis test, and Wilcoxon signed rank test were used to evaluate significant differences (p < 0.05) in peak temperatures, variations between cements, and clinical outcome. All procedures were completed without complications, achieving good clinical outcomes (p < 0.0001). Regarding average peak temperature, cements were divided into three groups: A (over 60{sup o}C), B (from 50{sup o} to 60{sup o}C), and C (below 50{sup o}C). Peak temperature in Group A (86.7 {+-} 10.7{sup o}C) was significantly higher (p = 0.0172) than that in Groups B (60.5 {+-} 3.7{sup o}C) and C (44.8 {+-} 2.6{sup o}C). The average of all thermocouples showed an extremely significant difference (p = 0.0002) between groups. None of the tested cements maintained a temperature {>=}45{sup o}C for more than 30 min. These data suggest that back-pain improvement is obtained not by thermal necrosis but by mechanical consolidation only. The relative necrotic thermal effect in vertebral metastases seems to confirm that analgesia must be considered the main intent of PV.

Anselmetti, Giovanni Carlo, E-mail: giovanni.anselmetti@ircc.it; Manca, Antonio [Institute for Cancer Research and Treatment (IRCC), Interventional Radiology Unit (Italy); Kanika, Khanna; Murphy, Kieran [Johns Hopkins Hospital, Radiology and Radiological Science (United States); Eminefendic, Haris [Institute for Cancer Research and Treatment (IRCC), Radiology Unit (Italy); Masala, Salvatore ['Tor Vergata' University General Hospital, Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy (Italy); Regge, Daniele [Institute for Cancer Research and Treatment (IRCC), Radiology Unit (Italy)

2009-05-15T23:59:59.000Z

49

Biodegradable synthetic bone composites  

DOE Patents [OSTI]

The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component; such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

Liu, Gao; Zhao, Dacheng; Saiz, Eduardo; Tomsia, Antoni P.

2013-01-01T23:59:59.000Z

50

On the Estimation of Bone Status Rasmus Paulsen  

E-Print Network [OSTI]

Osteoporosis Diagnostics. The subject of this thesis is medical image analysis with special attention to X Reinhold Paulsen Keywords Osteoporosis, bone status, radius, contact radiographs, cortical geometry, en algorithm developed by Torsana Osteoporosis Diagnostics. A simulated bone is made by simulated x

51

arm bones: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

TO ENSURE HUMAN SAFETY Lingqi Zeng and Gary M. Bone Engineering Websites Summary: , and robot and human velocities. The impact experiments are performed with an apparatus...

52

Independent measurement of femoral cortical thickness and cortical bone density using clinical CT  

E-Print Network [OSTI]

to measure, there is often an unequivocal need to be able to decompose it into its constituent parts. For example, in studying the effects of osteoporosis treatment with two different drugs, Teriparatide (Poole et al., 2011) and Denosumab (Poole et al., 2012a...

Treece, G. M.; Gee, A. H.

2014-12-05T23:59:59.000Z

53

Research Finds Vitamin D Deficiency Affects Bone Quality  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of vitamin D, the "sunshine vitamin," have been previously linked to the health and fracture risk of human bone on the basis of low calcium intake and reduced bone density. The...

54

Calibration Human Voxel Phantoms for In Vivo Measurement of ''2 sup 4 sup 1 Am in Bone at the Whole Body Counter Facility of CIEMAT  

E-Print Network [OSTI]

The Whole Body Counting facility of CIEMAT is capable of carrying out In-Vivo measurements of radionuclides emitting X-rays and low energy gamma radiation internally deposited in the body. The system to use for this purpose consists of flour Low energy Germanium (LeGe) Camberra detectors working in the energy range from 10 to 1000 keV. Physical phantoms with a known contamination in the organ of interest are normally used for the calibration of the LEGe detection system. In this document we present a calibration method using the Monte Carlo technique (MCNP4C) over a voxel phantom obtained from a computerized tomography of a real human head. The phantom consists of 104017 (43x59x41) cubic voxels, 4 mn on each side, os specific tissues, but for this simulation only two types are taken into account: adipose tissue and hard bone. The skull is supposed to be contaminated with ''241 Am and the trajectories of the photons are simulated till they reach the germanium detectors. The detectors were also simulated in det...

Moraleda, M; Navarro, J F; Navarro, T

2002-01-01T23:59:59.000Z

55

Gyrification from constrained cortical expansion  

E-Print Network [OSTI]

The exterior of the mammalian brain - the cerebral cortex - has a conserved layered structure whose thickness varies little across species. However, selection pressures over evolutionary time scales have led to cortices that have a large surface area to volume ratio in some organisms, with the result that the brain is strongly convoluted into sulci and gyri. Here we show that the gyrification can arise as a nonlinear consequence of a simple mechanical instability driven by tangential expansion of the gray matter constrained by the white matter. A physical mimic of the process using a layered swelling gel captures the essence of the mechanism, and numerical simulations of the brain treated as a soft solid lead to the formation of cusped sulci and smooth gyri similar to those in the brain. The resulting gyrification patterns are a function of relative cortical expansion and relative thickness (compared with brain size), and are consistent with observations of a wide range of brains, ranging from smooth to highly convoluted. Furthermore, this dependence on two simple geometric parameters that characterize the brain also allows us to qualitatively explain how variations in these parameters lead to anatomical anomalies in such situations as polymicrogyria, pachygyria, and lissencephalia.

Tuomas Tallinen; Jun Young Chung; John S. Biggins; L. Mahadevan

2015-03-12T23:59:59.000Z

56

atrofia cortical posterior: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cortical systems for local and global integration in discourse comprehension Giovanna Egidi a, Biology and Medicine Websites Summary: Cortical systems for local and global...

57

abrogated cortical porosity: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cortical systems for local and global integration in discourse comprehension Giovanna Egidi a, Biology and Medicine Websites Summary: Cortical systems for local and global...

58

auditiva aferente cortical: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cortical systems for local and global integration in discourse comprehension Giovanna Egidi a, Biology and Medicine Websites Summary: Cortical systems for local and global...

59

adreno cortical enzyme: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cortical systems for local and global integration in discourse comprehension Giovanna Egidi a, Biology and Medicine Websites Summary: Cortical systems for local and global...

60

adrenal cortical adenoma: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cortical systems for local and global integration in discourse comprehension Giovanna Egidi a, Biology and Medicine Websites Summary: Cortical systems for local and global...

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

accumbens cortical glutamate: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cortical systems for local and global integration in discourse comprehension Giovanna Egidi a, Biology and Medicine Websites Summary: Cortical systems for local and global...

62

adrenal cortical carcinoma: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cortical systems for local and global integration in discourse comprehension Giovanna Egidi a, Biology and Medicine Websites Summary: Cortical systems for local and global...

63

Modeling Cortical Plasticity Based on Adapting Lateral Interaction  

E-Print Network [OSTI]

A neural network model called LISSOM for the cooperative self-organization of afferent and lateral connections in cortical maps is applied to modeling cortical plasticity. After self-organization, the LISSOM maps are in a dynamic equilibrium with the input, and reorganize like the cortex in response to simulated cortical lesions and intracortical microstimulation. The model predicts that adapting lateral interactions are fundamental to cortical reorganization, and suggests techniques to hasten recovery following sensory cortical surgery.

64

FGF-23 in bone biology  

E-Print Network [OSTI]

6 REVIEW FGF-23 in bone biology Katherine Wesseling-Perryin impairments in bone biology. Although the defectiveof the protein on bone biology, a growing compendium of data

Wesseling-Perry, Katherine

2010-01-01T23:59:59.000Z

65

INVEST IN YOUR BONES Bone Basics  

E-Print Network [OSTI]

replace- ment at menopause may prevent bone loss and/or osteoporosis. Also find out if there is a need in your bones? Osteoporosis, a major health problem in America, affects over 10 million persons, with 34 million at a high risk of developing the disease (National Osteoporosis Foundation, 2010). Dubbed

66

E-Print Network 3.0 - apparent trabecular bone Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

trabecular bone density in human... Trabecular ... Source: Gefen, Amit - Department of Biomedical Engineering, Tel Aviv University Collection: Engineering ; Biology and Medicine...

67

Fracture, aging, and disease in bone J.W. Ager III  

E-Print Network [OSTI]

Fracture, aging, and disease in bone J.W. Ager III Materials Sciences Division, Lawrence Berkeley-known increase with age in fracture risk of human bone is essential. This also represents a challenge from materials science and fracture mechanics viewpoints. Bone has a complex, hierarchical structure

Ritchie, Robert

68

Adaptive scapula bone remodeling computational simulation: Relevance to regenerative medicine  

SciTech Connect (OSTI)

Shoulder arthroplasty success has been attributed to many factors including, bone quality, soft tissue balancing, surgeon experience, and implant design. Improved long-term success is primarily limited by glenoid implant loosening. Prosthesis design examines materials and shape and determines whether the design should withstand a lifetime of use. Finite element (FE) analyses have been extensively used to study stresses and strains produced in implants and bone. However, these static analyses only measure a moment in time and not the adaptive response to the altered environment produced by the therapeutic intervention. Computational analyses that integrate remodeling rules predict how bone will respond over time. Recent work has shown that subject-specific two- and three dimensional adaptive bone remodeling models are feasible and valid. Feasibility and validation were achieved computationally, simulating bone remodeling using an intact human scapula, initially resetting the scapular bone material properties to be uniform, numerically simulating sequential loading, and comparing the bone remodeling simulation results to the actual scapula’s material properties. Three-dimensional scapula FE bone model was created using volumetric computed tomography images. Muscle and joint load and boundary conditions were applied based on values reported in the literature. Internal bone remodeling was based on element strain-energy density. Initially, all bone elements were assigned a homogeneous density. All loads were applied for 10 iterations. After every iteration, each bone element’s remodeling stimulus was compared to its corresponding reference stimulus and its material properties modified. The simulation achieved convergence. At the end of the simulation the predicted and actual specimen bone apparent density were plotted and compared. Location of high and low predicted bone density was comparable to the actual specimen. High predicted bone density was greater than actual specimen. Low predicted bone density was lower than actual specimen. Differences were probably due to applied muscle and joint reaction loads, boundary conditions, and values of constants used. Work is underway to study this. Nonetheless, the results demonstrate three dimensional bone remodeling simulation validity and potential. Such adaptive predictions take physiological bone remodeling simulations one step closer to reality. Computational analyses are needed that integrate biological remodeling rules and predict how bone will respond over time. We expect the combination of computational static stress analyses together with adaptive bone remodeling simulations to become effective tools for regenerative medicine research.

Sharma, Gulshan B., E-mail: gbsharma@ucalgary.ca [Emory University, Department of Radiology and Imaging Sciences, Spine and Orthopaedic Center, Atlanta, Georgia 30329 (United States); University of Pittsburgh, Swanson School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213 (United States); University of Calgary, Schulich School of Engineering, Department of Mechanical and Manufacturing Engineering, Calgary, Alberta T2N 1N4 (Canada); Robertson, Douglas D., E-mail: douglas.d.robertson@emory.edu [Emory University, Department of Radiology and Imaging Sciences, Spine and Orthopaedic Center, Atlanta, Georgia 30329 (United States); University of Pittsburgh, Swanson School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213 (United States)

2013-07-01T23:59:59.000Z

69

Development of high strength hydroxyapatite for bone tissue regeneration using nanobioactive glass composites  

SciTech Connect (OSTI)

With an increasing demand of biocompatible bone substitutes for the treatment of bone diseases and bone tissue regeneration, bioactive glass composites are being tested to improvise the osteoconductive as well as osteoinductive properties. Nanobioactive glass (nBG) composites, having composition of SiO{sub 2} 70 mol%, CaO 26 mol % and P{sub 2}O{sub 5} 4 mol% were prepared by Freeze drying method using PEG-PPG-PEG co-polymer. Polymer addition improves the mechanical strength and porosity of the scaffold of nBG. Nano Bioactive glass composites upon implantation undergo specific reactions leading to the formation of crystalline hydroxyapatite (HA). This is tested in vitro using Simulated Body Fluid (SBF). This high strength hydroxyapatite (HA) layer acts as osteoconductive in cellular environment, by acting as mineral base of bones, onto which new bone cells proliferate leading to new bone formation. Strength of the nBG composites as well as HA is in the range of cortical and cancellous bone, thus proving significant for bone tissue regeneration substitutes.

Shrivastava, Pragya; Dalai, Sridhar; Vijayalakshmi, S. [Centre for Research in Nanotechnology and Science, IIT Bombay (India); Sudera, Prerna; Sivam, Santosh Param [Amity Institute of Nanotechnology, Amity University, Noida, Uttar Pradesh-201303 (India); Sharma, Pratibha [Dept of Energy Science and Engineering, IIT Bombay (India)

2013-02-05T23:59:59.000Z

70

RESEARCH ARTICLE Outline of a novel architecture for cortical computation  

E-Print Network [OSTI]

RESEARCH ARTICLE Outline of a novel architecture for cortical computation Kaushik Majumdar Received for cortical computation has been proposed. This architecture is com- posed of computing paths consisting for this type of computation has been the von Neumann architecture where the memory is accessed

Bandyopadhyay, Antar

71

age-related cortical cataract: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cortical systems for local and global integration in discourse comprehension Giovanna Egidi a, Biology and Medicine Websites Summary: Cortical systems for local and global...

72

attention-related cortical functional: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Cortical systems for local and global integration in discourse comprehension Giovanna Egidi a, Biology and Medicine Websites Summary: Cortical systems for local and global...

73

E-Print Network 3.0 - abnormal cortical processing Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

processing Search Powered by Explorit Topic List Advanced Search Sample search results for: abnormal cortical processing Page: << < 1 2 3 4 5 > >> 1 Cortical thinning in cingulate...

74

FRACTAL COMPLEXITY OF THE HUMAN CORTEX IS INCREASED IN WILLIAMS SYNDROME  

E-Print Network [OSTI]

FRACTAL COMPLEXITY OF THE HUMAN CORTEX IS INCREASED IN WILLIAMS SYNDROME 1 Paul M. Thompson, 1 algorithm to measure the fractal dimension, or complexity, of the human cerebral cortex. Cortical complexity, the proposed fractal dimension takes into account the full 3D cortical surface geometry, and is independent

Thompson, Paul

75

Ena/VASP Proteins Regulate Cortical Neuronal Positioning  

E-Print Network [OSTI]

Development of the multilayered cerebral cortex involves extensive regulated migration of neurons arising from the deeper germinative layers of the mammalian brain [1]. The anatomy and formation of the cortical layers has ...

Goh, Keow Lin

76

Topic 7 Organization of Motor System -Cortical Motor Areas  

E-Print Network [OSTI]

Cartoon, 1986 Electrical stimulation produces movement of contralateral body parts. #12;4 Motor Homunculus previous stimulation technique · Insert electrode into cortical layer V and use electrical stimulation" somatotopic map vs "more complex" map #12;

Sergio, Lauren E.

77

DYNAMICS OF NEURONAL ACTIVATION AND INTERACTIONS IN CORTICAL FRONTAL  

E-Print Network [OSTI]

cortices of behaving monkeys, by using micro-electrode arrays. The monkeys performed a sensorimotor task relation between similarity in the single cells' preferred directions (PD) and their pair-wise correlation

78

Cortical Activation During Spatiotemporal Processing in the Infant Brain  

E-Print Network [OSTI]

CORTICAL ACTIVATION DURING SPATIOTEMPORAL PROCESSING IN THE INFANT BRAIN A Thesis by JENNIFER RUTH ARMSTRONG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE December 2008 Major Subject: Psychology CORTICAL ACTIVATION DURING SPATIOTEMPORAL PROCESSING IN THE INFANT BRAIN A Thesis by JENNIFER RUTH ARMSTRONG Submitted to the Office of Graduate Studies...

Armstrong, Jennifer R.

2010-01-14T23:59:59.000Z

79

A Novel Method for the Evaluation of Mechanical Properties of Cancellous Bone in the Rat Distal Femur  

E-Print Network [OSTI]

Walton Lucas, B.S., Lipscomb University Co-Chairs of Advisory Committee: Dr. Harry Hogan Dr. Susan Bloomfield The mechanical properties of the cancellous bone in the laboratory rat animal model... the cortical shell for 50 slices in a region starting ~0.5 mm below the most proximal portion of the growth plate for each animal. Images were binarized (threshold of 100 on a 0-255 scale) and the following parameters were assessed for the three- dimensional...

Lucas, Matthew W.

2010-01-14T23:59:59.000Z

80

Digital electronic bone growth stimulator  

DOE Patents [OSTI]

A device is described for stimulating bone tissue by applying a low level alternating current signal directly to the patient`s skin. A crystal oscillator, a binary divider chain and digital logic gates are used to generate the desired waveforms that reproduce the natural electrical characteristics found in bone tissue needed for stimulating bone growth and treating osteoporosis. The device, powered by a battery, contains a switch allowing selection of the correct waveform for bone growth stimulation or osteoporosis treatment so that, when attached to the skin of the patient using standard skin contact electrodes, the correct signal is communicated to the underlying bone structures. 5 figs.

Kronberg, J.W.

1995-05-09T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Digital electronic bone growth stimulator  

DOE Patents [OSTI]

A device for stimulating bone tissue by applying a low level alternating current signal directly to the patient's skin. A crystal oscillator, a binary divider chain and digital logic gates are used to generate the desired waveforms that reproduce the natural electrical characteristics found in bone tissue needed for stimulating bone growth and treating osteoporosis. The device, powered by a battery, contains a switch allowing selection of the correct waveform for bone growth stimulation or osteoporosis treatment so that, when attached to the skin of the patient using standard skin contact electrodes, the correct signal is communicated to the underlying bone structures.

Kronberg, James W. (Aiken, SC)

1995-01-01T23:59:59.000Z

82

E-Print Network 3.0 - alveolar bone formation Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sutures to Deciduous Dentition in Nonhuman Primates K... .D., E.R. Dumont, Ph.D., T.D. Smith, Ph.D. Objective: The relationship of the human premaxillary bone Source: Dumont,...

83

INVEST IN YOUR BONES Living with Osteoporosis  

E-Print Network [OSTI]

INVEST IN YOUR BONES Living with Osteoporosis Leaflet 5 Living with osteoporosis can be done environment safe to avoid falls. Early detection of bone loss or osteoporosis is now possible with bone to be most effective in reducing bone loss during the five to ten years following menopause, when bone loss

84

E-Print Network 3.0 - age-related cortical brain Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

brain Search Powered by Explorit Topic List Advanced Search Sample search results for: age-related cortical brain Page: << < 1 2 3 4 5 > >> 1 Mapping Cortical Thickness and Gray...

85

Using High Angular Resolution Diffusion Imaging Data to Discriminate Cortical Regions  

E-Print Network [OSTI]

of the signal variation as non­random and reproducible is the critical condition for successful cortical

Sereno, Martin

86

R326 Dispatch Nuclear migration: Cortical anchors for cytoplasmic dynein  

E-Print Network [OSTI]

dynein, and provide a critical link in understanding the basis of nuclear migration in yeast. The nuclearR326 Dispatch Nuclear migration: Cortical anchors for cytoplasmic dynein Kerry Bloom Nuclear body that rolls around at random inside the sack of a eukaryotic cell. Controlled nuclear movements

87

Auditory cortical neuron response dierences under isourane versus pentobarbital anesthesia  

E-Print Network [OSTI]

Auditory cortical neuron response di¡erences under iso£urane versus pentobarbital anesthesia Steven pentobarbital anesthesia in a within subject study control design. Initial microelectrode recordings were made under isoflurane anesthesia. After a several hour washout period, recordings were repeated at spatially

Wang, Xiaoqin

88

Fracture, aging and disease in bone  

E-Print Network [OSTI]

separate during bone fracture. Nature Materials 4, 612 (on nonagenarians with hip fractures? Injury 30, 169 (1999).bone mass as predictors of fracture in a prospective study.

Ager, J.W.; Balooch, G.; Ritchie, R.O.

2006-01-01T23:59:59.000Z

89

Brain Image Registration Using CorticallyBrain Image Registration Using Cortically Constrained Harmonic MappingsConstrained Harmonic Mappings  

E-Print Network [OSTI]

Harmonic MappingsConstrained Harmonic Mappings Anand A Joshi1, David W Shattuck2, Paul M Thompson2 and Richard M Leahy1 Subcortical Structure AIR Harmonic HAMMER Harmonic +Intensity Left Thalamus 0.79 0.68 0. Extrapolation of the surface map to the entire cortical volume by a harmonic map. 3. Refinement of the harmonic

Leahy, Richard M.

90

J Bone Miner Res . Author manuscript Fracture risk prediction using BMD and clinical risk factors in early  

E-Print Network [OSTI]

,651 peri- and early post-menopausal women (mean age (± SD): 54 4 yr) with a mean follow-up period of 13 Density ; Female ; Fractures, Bone ; etiology ; Humans ; Middle Aged ; Osteoporosis, Postmenopausal definition of osteoporosis ( ), i.e. a bone mineral density (BMD) value less than 2.5 standard deviations

Paris-Sud XI, Université de

91

Chronic in vivo imaging of dendritic plasticity and functional remapping after cortical stroke  

E-Print Network [OSTI]

contralateral hemisphere after stroke, has been conducted inaffected areas after stroke. This hypothesis was initiallyremapping after cortical stroke. Cereb Cortex. 2012 Apr 11;

Johnston, David

2012-01-01T23:59:59.000Z

92

E-Print Network 3.0 - abnormal cortical development Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

development Search Powered by Explorit Topic List Advanced Search Sample search results for: abnormal cortical development Page: << < 1 2 3 4 5 > >> 1 Ultrasound Obstet Gynecol....

93

E-Print Network 3.0 - amygdala-orbitofrontal cortical functional...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Complementary... indicates that this cortical region is engaged in multiple aspects of brain function, as reviewed... College of Medicine. His group studies the functional...

94

E-Print Network 3.0 - anti-fya seraclone human Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

presented. Sphere-based geometric models... are used for the human and robot due to the efficiency of the distance computation. The collision avoidance Source: Bone, Gary -...

95

Positive modulator of bone morphogenic protein-2  

DOE Patents [OSTI]

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

Zamora, Paul O. (Gaithersburg, MD); Pena, Louis A. (Poquott, NY); Lin, Xinhua (Plainview, NY); Takahashi, Kazuyuki (Germantown, MD)

2009-01-27T23:59:59.000Z

96

BONE CARE FOR THE POSTMENOPAUSAL WOMAN  

E-Print Network [OSTI]

Osteoporosis is a disease characterized by low bone mass and deterioration in the microarchitecture of bone tissue, leading to an increased risk of fracture. Osteoporosis occurs when the bone mass decreases more fracture). Osteoporosis has no signs or symptoms until a fracture occurs ­ this is why it is often called

Shihadeh, Alan

97

pH dependence and compartmentalization of zinc transported across plasma membrane of rat cortical neurons  

E-Print Network [OSTI]

pH dependence and compartmentalization of zinc transported across plasma membrane of rat corticalH dependence and compartmental- ization of zinc transported across plasma membrane of rat cortical neurons. Am; ion transport; transition elements; primary culture IT IS KNOWN THAT Zn2 can enter neurons by two

98

Reply: Lithium and Increased Cortical Gray Matter--More Tissue or More Water?  

E-Print Network [OSTI]

Reply: Lithium and Increased Cortical Gray Matter--More Tissue or More Water? To the Editor: W e cortices, in lithium-treated patients with bipolar disorder, relative to healthy control subjects (1). Dr patients. Although lithium's effects on body water homeostasis (2) are important to consider, the absence

Thompson, Paul

99

Sulcus detection in planar projections of cortical surfaces Mutawarra Hussain and Ela Claridge  

E-Print Network [OSTI]

projection, the cortical part of the brain volume is transformed into a stack of 2D slices, each representing a pixel-deep hemispherical shell. In this representation, cortex forms a nearly-planar surface, while require substantial computing power. This paper describes a method for finding the cortical position

Claridge, Ela

100

A Rho-signaling pathway mediates cortical granule translocation in the sea urchin oocyte  

E-Print Network [OSTI]

´mica, Universidad de Guanajuato, Col. Noria Alta, Guanajuato, Gto 3600, A.P. 187, Mexico b Department of Molecular-mediated process. We tested the hypothesis that these cortical granule dynamics were regulated by Rho, a GTPase of the cortical granules in the cortex, as well as their fusion at fertilization, are Rho-independent processes

Wessel, Gary M.

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

CORTICAL BRAIN SURFACE MAPPING FOR STUDYING PARTIAL VOLUME EFFECTS IN BRAIN FDG PET IMAGES  

E-Print Network [OSTI]

CORTICAL BRAIN SURFACE MAPPING FOR STUDYING PARTIAL VOLUME EFFECTS IN BRAIN FDG PET IMAGES Hillary PET images is confounded by tissue atrophy and partial volume effects, especially in patients-based cortical brain surface mapping technique to account for partial volume effects on brain FDG PET images

Thompson, Paul

102

On the role of inhibition in cortical plasticity: a computational study \\Lambda Lubica Benuskov'a  

E-Print Network [OSTI]

, experience, cortical plasticity, dynamic synaptic modification threshold, inhibition, non­specificity 1On the role of inhibition in cortical plasticity: a computational study \\Lambda Lubica BeŸnuŸskov'a Department of Computer Science and Engineering Slovak Technical University, 81219 Bratislava, Slovakia

Benuskova, Luba

103

Digital electronic bone growth stimulator  

DOE Patents [OSTI]

The present invention relates to the electrical treatment of biological tissue. In particular, the present invention discloses a device that produces discrete electrical pulse trains for treating osteoporosis and accelerating bone growth. According to its major aspects and broadly stated, the present invention consists of an electrical circuit configuration capable of generating Bassett-type waveforms shown with alternative signals provide for the treatment of either fractured bones or osteoporosis. The signal generator comprises a quartz clock, an oscillator circuit, a binary divider chain, and a plurality of simple, digital logic gates. Signals are delivered efficiently, with little or no distortion, and uniformly distributed throughout the area of injury. Perferably, power is furnished by widely available and inexpensive radio batteries, needing replacement only once in several days. The present invention can be affixed to a medical cast without a great increase in either weight or bulk. Also, the disclosed stimulator can be used to treat osteoporosis or to strengthen a healing bone after the cast has been removed by attaching the device to the patient`s skin or clothing.

Kronberg, J.W.

1993-01-01T23:59:59.000Z

104

The Wnt Co-receptor LRP5 Is Essential for Skeletal Mechanotransduction but Not for the Anabolic Bone  

E-Print Network [OSTI]

- of-function mutations in LRP5 cause the human skeletal disease osteoporosis-pseudoglioma syndrome com- ponent of the skeletal fragility phenotype in individuals affected with osteoporosis in the regulation of bone mass and strength. For example, the autosomal recessive human disease osteoporosis

105

WRITTEN IN BONE: Bone Biographer's Casebook Douglas Owsley and Karin Bruwelheide  

E-Print Network [OSTI]

afflictions that would have made daily life miserable. In addition to dental disease and gout, his bones were

Mathis, Wayne N.

106

Composite bone substitutes prepared by two methods  

E-Print Network [OSTI]

Hydroxyapatite-polyethylene composites: effect of graftingof braded carbon/PEEK composite compression bone plates,”Koch, “Hydroxyapatite/SiO2 Composites via Freeze Casting for

Lee, Hoe Yun; Lee, Hoe Yun

2012-01-01T23:59:59.000Z

107

Ultrasound-Confirmed Frontal Bone Fracture  

E-Print Network [OSTI]

table--frontal sinus fractures. Facial Plast Surg Clin NorthConfirmed Frontal Bone Fracture Jeremy N. Johnson, DO Danielan isolated comminuted fracture of the left frontal sinus

Johnson, Jeremy N; Crandall, Stephen; Kang, Christopher S

2009-01-01T23:59:59.000Z

108

Hydroxyapatite-binding peptides for bone growth and inhibition  

DOE Patents [OSTI]

Hydroxyapatite (HA)-binding peptides are selected using combinatorial phage library display. Pseudo-repetitive consensus amino acid sequences possessing periodic hydroxyl side chains in every two or three amino acid sequences are obtained. These sequences resemble the (Gly-Pro-Hyp).sub.x repeat of human type I collagen, a major component of extracellular matrices of natural bone. A consistent presence of basic amino acid residues is also observed. The peptides are synthesized by the solid-phase synthetic method and then used for template-driven HA-mineralization. Microscopy reveal that the peptides template the growth of polycrystalline HA crystals .about.40 nm in size.

Bertozzi, Carolyn R. (Berkeley, CA); Song, Jie (Shrewsbury, MA); Lee, Seung-Wuk (Walnut Creek, CA)

2011-09-20T23:59:59.000Z

109

Kinetic trajectory decoding using motor cortical ensembles Andrew H. Fagg1  

E-Print Network [OSTI]

0 Kinetic trajectory decoding using motor cortical ensembles Andrew H. Fagg1 , Greg Ojakangas2, Norman, OK 2 Dept. of Physics, Drury University 3 Dept. of Physiology, Northwestern University, Chicago

Fagg, Andrew H.

110

Shell Formation and Bone Strength Laying Hens  

E-Print Network [OSTI]

Shell Formation and Bone Strength in Laying Hens Effects of Age, Daidzein and Exogenous Estrogen Cover aquarelle: E. Spörndly-Nees #12;Shell Formation and Bone Strength in Laying Hens Effects of Age eggshells as shell quality declines with age during the laying period. This is a concern for food safety

111

Curr Pharm Des . Author manuscript Bisphosphonates and bone diseases: past, present and future  

E-Print Network [OSTI]

involving excessive bone resorption which include post-menopausal osteoporosis, Paget s disease of bone

Paris-Sud XI, Université de

112

Tracking cortical entrainment in neural activity: Auditory processes in human temporal cortex  

E-Print Network [OSTI]

MNE (Hämäläinen and Ilmoniemi, 1994), neuro-anatomically constrained by MRI images obtained using a GRAPPA 3D MPRAGE sequence (TR=2250ms; TE = 2.99ms; flip-angle = 9?; acceleration factor = 2) on a 3T Tim Trio (Siemens, Erlangen, Germany) with 1mm...

Thwaites, Andrew; Nimmo-Smith, Ian; Fonteneau, Elisabeth; Patterson, Roy D.; Buttery, Paula; Marslen-Wilson, William D.

2015-02-10T23:59:59.000Z

113

Think of your bones as a "bank" where  

E-Print Network [OSTI]

can get osteoporosis (ah-stee-oh-puh- ROH-sis) when you get older. Osteoporosis is a disease in which the bones become weak and more likely to break (fracture). People with osteoporosis most often break bones in the hip, spine, and wrist. 1 #12;Normal bone Bone with osteoporosis Reprinted from The Surgeon General

Baker, Chris I.

114

Evaluation of Bone Fixation Implants  

E-Print Network [OSTI]

This research investigates the effects of the human body on the mechanical, chemical, and morphological properties of the surface of internal fixation devices. Stainless steel and titanium devices that had failed were provided from the Shandong...

Perkins, Luke 1990-

2012-12-10T23:59:59.000Z

115

Composite gelatin delivery system for bone regeneration  

E-Print Network [OSTI]

In this thesis, the chemical/mechanical properties and biocompatibility of gelatin were investigated to produce a gelatin scaffold for the release of bone morphogenetic proteins (BMPs) from composite particles. This delivery ...

Hager, Elizabeth A. (Elizabeth Ann)

2005-01-01T23:59:59.000Z

116

Microdamage accumulation in bovine trabecular bone  

E-Print Network [OSTI]

When bone is loaded beyond its failure point, it develops damage in the form of microcracks. Normally, microcracks are repaired by the remodeling process, limiting the number of in vivo microcracks. However, if the rate ...

Moore, Tara L. Arthur (Tara Lee Arthur), 1972-

2001-01-01T23:59:59.000Z

117

E-Print Network 3.0 - areal bone mineral Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(DXA)-derived areal bone mineral density (BMD) and reductions in vertebral fracture incidence... than the bone volume fraction (mineralized bone volumebulk volume).12...

118

E-Print Network 3.0 - assessing bone mass Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

on assessment of bone mass... the amount of bone mass and predict the risk for fracture. However, the cur- rently available techniques... - tive assessment of bone ......

119

E-Print Network 3.0 - antibody-facilitated bone marrow Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of off... marrow, manifested as artifactual broadening of bone micro-structures in the image. The resulting images... (B0) at bone and bone marrow ... Source: Southern...

120

E-Print Network 3.0 - adaptive bone remodelling Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

various sites and involves resorption by osteoclast, followed... mineral density and bone micro- architecture. Our paper focuses on bone microstructure and remodeling... in bone...

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Cortical Enhanced Tissue Segmentation of Neonatal Brain MR Images Acquired by a Dedicated Phased Array Coil  

E-Print Network [OSTI]

Cortical Enhanced Tissue Segmentation of Neonatal Brain MR Images Acquired by a Dedicated Phased Carolina at Chapel Hill Abstract The acquisition of high quality MR images of neonatal brains is largely hampered by their characteristically small head size and low tissue contrast. As a result, subsequent image

Utah, University of

122

From the decoding of cortical activities to the control of a JACO robotic arm  

E-Print Network [OSTI]

From the decoding of cortical activities to the control of a JACO robotic arm: a whole processing in the cortex of a monkey and replicates the associated movements on a JACO robotic arm by Kinova. We developed the data, compute the position of the robotic finger and send this position to the robotic arm. More pre

Paris-Sud XI, Université de

123

Efficient Representation of Cortical Convolutions for the Analysis of Brain Surface Topology  

E-Print Network [OSTI]

Efficient Representation of Cortical Convolutions for the Analysis of Brain Surface Topology Peter of the brain in MR and CT clearly con- veying the whole surface topology. For the comparison of the provided with direct volume rendering. Considering brain information exclusively, and ensuring a standardized

Blanz, Volker

124

Detecting Cortical Surface Regions in Structural MR Data Biswajit Bose1,  

E-Print Network [OSTI]

Detecting Cortical Surface Regions in Structural MR Data Biswajit Bose1, , John Fisher1 , Bruce on a challenging ex-vivo structural MR dataset for detection of Brodmann area 17. 1. Introduction Detection-resolution MR volume. Figure 1 shows a slice through structural MR data of the primary vi- sual cortex, where BA

Fisher III, John

125

SELF-ORGANIZATION AND NEURONAL AVALANCHES IN NETWORKS OF DISSOCIATED CORTICAL NEURONS  

E-Print Network [OSTI]

networks developing in vitro and chronically coupled to micro-electrode arrays (MEAs) rep- resentSELF-ORGANIZATION AND NEURONAL AVALANCHES IN NETWORKS OF DISSOCIATED CORTICAL NEURONS V. PASQUALE cultured onto micro-electrode arrays exhibit characteristic patterns of electrophysiological activity

Arleo, Angelo

126

The Cotton Kinesin-Like Calmodulin-Binding Protein Associates with Cortical Microtubles in Cotton Fibers  

SciTech Connect (OSTI)

Microtubules in interphase plant cells form a cortical array, which is critical for plant cell morphogenesis. Genetic studies imply that the minus end-directed microtubule motor kinesin-like calmodulin-binding protein (KCBP) plays a role in trichome morphogenesis in Arabidopsis. However, it was not clear whether this motor interacted with interphase microtubules. In cotton (Gossypium hirsutum) fibers, cortical microtubules undergo dramatic reorganization during fiber development. In this study, cDNA clones of the cotton KCBP homolog GhKCBP were isolated from a cotton fiber-specific cDNA library. During cotton fiber development from 10 to 21 DPA, the GhKCBP protein level gradually decreases. By immunofluorescence, GhKCBP was detected as puncta along cortical microtubules in fiber cells of different developmental stages. Thus the results provide evidence that GhKCBP plays a role in interphase cell growth likely by interacting with cortical microtubules. In contrast to fibers, in dividing cells of cotton, GhKCBP localized to the nucleus, the microtubule preprophase band, mitotic spindle, and the phragmoplast. Therefore KCBP likely exerts multiple roles in cell division and cell growth in flowering plants.

Preuss, Mary L.; Delmar, Deborah P.; Liu, Bo

2003-05-01T23:59:59.000Z

127

Final Report for completed IPP Project:"Development of Plasma Ablation for Soft Tissue and Bone Surgery"  

SciTech Connect (OSTI)

ArthroCare is a medical device company that develops, manufactures, and markets an advanced surgical tool, a plasma electro-surgical system for cutting and removing tissue. The hand-held electrical discharge device produces plasma in a biocompatible conductive fluid and tissue to which it is applied during surgery. Its products allow surgeons to operate with increased precision and accuracy, limiting damage to surrounding tissue thereby reducing pain and speeding recovery for the patient. In the past, the design of ArthfoCare's plasma wands has been an empirical undertaking. One goal of this R&D program was to put the phenomena involved on a sound scientific footing, allowing optimization of existing plasma based electro-surgery system technology, and the design and manufacture of new and improved kinds of scalpels, in particular for the surgical cutting of bone. Another important related goal of the program was to develop, through an experimental approach, new plasma wand approaches to the cutting ('shaving') of hard bone tissue. The goals of the CRADA were accomplished - computer models were used to predict important parameters of the plasma discharge and the bone environment, and several different approaches to bone-shaving were developed and demonstrated. The primary goal of the project was to develop and demonstrate an atmospheric-pressure plasma tool that is suitable for surgical use for shaving bone in humans. This goal was accomplished, in fact with several different alternative plasma approaches. High bone ablation speeds were measured. The use of probes ('plasma wand' - the surgical tool) with moving active electrodes was also explored, and there are advantages to this method. Another important feature is that the newly-exposed bone surface have only a very thin necrosis layer; this feature was demonstrated. This CRADA has greatly advanced our understanding of bone removal by atmospheric pressure plasmas in liquid, and puts ArthroCare in a good position to develop the techniques for commercial (surgical) application.

Brown, Ian

2009-09-01T23:59:59.000Z

128

Photoplethysmography for non-invasive measurement of bone hemodynamic responses to changes in external pressure  

E-Print Network [OSTI]

Adequate blood supply and circulation in bones is required to maintain a healthy skeleton, and inadequate blood perfusion is associated with numerous bone pathologies and a decrease in bone mineral density (BMD). Bone ...

Mateus, Jaime (Pereira de Mateus Silva)

2011-01-01T23:59:59.000Z

129

Original article Analysis of muscle and bone weight variation  

E-Print Network [OSTI]

. The commonalities ranged from 0.76 (drumstick muscle) to 0.92 (neck bone) and the uniqueness (special size factors and drumstick bone factors. The correlation coefficient between the first factor score and carcass muscle was 0

Paris-Sud XI, Université de

130

Cellular and molecular immunotherapeutics derived from the bone marrow stroma  

E-Print Network [OSTI]

The bone marrow contains a multipotent stromal cell, commonly referred to as a mesenchymal stem cell (MSC). There has been recent interest in the clinical use of MSCs for cell-based therapy because: (1) bone marrow aspiration ...

Parekkadan, Biju

2008-01-01T23:59:59.000Z

131

Bisphosphonates and Bone diseases: past, present and future Bisphosphonates are stable analogues of the naturally-occuring inorganic  

E-Print Network [OSTI]

involving excessive bone resorption which include post-menopausal osteoporosis, Paget's disease of bone

Paris-Sud XI, Université de

132

Building Strong Bones: Calcium Information for Health Care Providers  

E-Print Network [OSTI]

intake of calcium.2 You can help children achieve lifelong bone health by talking to parents and young of calcium necessary for optimal bone development. Research suggests many parents don't know that children to three decades of life ·The rate at which bone is lost in the later years Although the consequences

Rau, Don C.

133

Prediction and Informative Risk Factor Selection of Bone Diseases  

E-Print Network [OSTI]

data and use these integrated features to effectively predict osteoporosis and bone fractures. We; disease memory; osteoporosis; bone fracture. ! 1 INTRODUCTION Risk factor (RF) analysis based on patients on the study of osteoporosis and bone fracture prediction. Over the past few decades, osteoporosis has been

Zhang, Aidong

134

The effects of eccentric training on muscle-bone function  

E-Print Network [OSTI]

The purpose of this study was to determine if eccentric exercise training can attenuate or prevent bone loss associated with estrogen-deficiency in the mouse model. A secondary purpose was to determine if any bone changes were due to changes in bone...

Hubal, Monica Jeanne

1999-01-01T23:59:59.000Z

135

INVEST IN YOUR BONES Daily Activities  

E-Print Network [OSTI]

INVEST IN YOUR BONES Daily Activities Leaflet 3 Another osteoporosis prevention step to decrease lifestyle. Let's see how you can do that. If you have osteoporosis, follow carefully the activity program. Remember the following about osteoporosis: is largely preventable and treatable is a serious

136

The cortical organization of audio-visual sentence comprehension: an fMRI study at 4 Tesla  

E-Print Network [OSTI]

The cortical organization of audio-visual sentence comprehension: an fMRI study at 4 Tesla Cheryl M Tesla. Participants viewed the face and upper body of a speaker via a video screen while listening

137

Scaling self-organizing maps to model large cortical networks  

E-Print Network [OSTI]

Self-organizing computational models with specific intracortical connections can explain many functional features of visual cortex, such as topographic orientation and ocular dominance maps. However, due to their computational requirements, it is difficult to use such detailed models to study large-scale phenomena like object segmentation and binding, object recognition, tilt illusions, optic flow, and fovea periphery interaction. This paper introduces two techniques that make large simulations practical. First, a set of general linear scaling equations for the RF-LISSOM self-organizing model is derived and shown to result in quantitatively equivalent maps over a wide range of simulation sizes. This capability makes it possible to debug small simulations and then scale them up to larger simulations only when needed. The scaling equations also facilitate the comparison of biological maps and parameters between individuals and species with different brain region sizes. Second, the equations are combined into a new growing map method called GLISSOM, which dramatically reduces the memory and computational requirements of large self-organizing networks. With GLISSOM it should be possible to simulate all of human V1 at the single-column level using existing supercomputers, making detailed computational study of large-scale phenomena possible.

2004-01-01T23:59:59.000Z

138

Approach- and Withdrawal-Oriented Responses to Social Rejection: The Role of Asymmetrical Frontal Cortical Activity  

E-Print Network [OSTI]

A Thesis by CARLY KATHRYN PETERSON Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved by: Chair of Committee, Eddie Harmon... Cortical Activity. (December 2009) Carly Kathryn Peterson, B.A., University of Wisconsin ? Madison Chair of Advisory Committee: Dr. Eddie Harmon-Jones Ostracism arouses negative affect. However, little is known about variables that influence...

Peterson, Carly Kathryn

2011-02-22T23:59:59.000Z

139

Modeling aspects of human memory for scientific study.  

SciTech Connect (OSTI)

Working with leading experts in the field of cognitive neuroscience and computational intelligence, SNL has developed a computational architecture that represents neurocognitive mechanisms associated with how humans remember experiences in their past. The architecture represents how knowledge is organized and updated through information from individual experiences (episodes) via the cortical-hippocampal declarative memory system. We compared the simulated behavioral characteristics with those of humans measured under well established experimental standards, controlling for unmodeled aspects of human processing, such as perception. We used this knowledge to create robust simulations of & human memory behaviors that should help move the scientific community closer to understanding how humans remember information. These behaviors were experimentally validated against actual human subjects, which was published. An important outcome of the validation process will be the joining of specific experimental testing procedures from the field of neuroscience with computational representations from the field of cognitive modeling and simulation.

Caudell, Thomas P. (University of New Mexico); Watson, Patrick (University of Illinois - Champaign-Urbana Beckman Institute); McDaniel, Mark A. (Washington University); Eichenbaum, Howard B. (Boston University); Cohen, Neal J. (University of Illinois - Champaign-Urbana Beckman Institute); Vineyard, Craig Michael; Taylor, Shawn Ellis; Bernard, Michael Lewis; Morrow, James Dan; Verzi, Stephen J.

2009-10-01T23:59:59.000Z

140

Bone Cancer Rates in Dinosaurs Compared with Modern Vertebrates  

E-Print Network [OSTI]

Data on the prevalence of bone cancer in dinosaurs is available from past radiological examination of preserved bones. We statistically test this data for consistency with rates extrapolated from information on bone cancer in modern vertebrates, and find that there is no evidence of a different rate. Thus, this test provides no support for a possible role of ionizing radiation in the K-T extinction event.

L. C. Natarajan; A. L. Melott; B. M. Rothschild; L. D. Martin

2007-10-16T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

BONE LOSS IN RELATION TO HYPOTHALAMIC ATROPHY IN ALZHEIMER'S DISEASE  

E-Print Network [OSTI]

considerable burden on the health system, patients, and caregivers. 1.2 Alzheimer’s Disease and Bone Loss Bone health is an important issue in aging and AD. Osteoporosis–related fractures are among the major health and socioeconomic concerns in aging... of bone fractures, and a determining factor in clinical diagnosis of osteoporosis (Ammann and Rizzoli 2003). Several studies in women suggest that low BMD is associated with poorer cognitive function and subsequent cognitive decline (Yaffe, Browner et al...

Loskutova, Natalia Y.

2011-05-12T23:59:59.000Z

142

On nano size structures for enhanced bone formation.  

E-Print Network [OSTI]

??Purpose The general aim of the present thesis was to investigate early bone response to titanium implants modified with nano size structures. Therefore, 1. a… (more)

Meirelles, Luiz

2007-01-01T23:59:59.000Z

143

Physiological Stress, Bone Growth and Development in Imperial Rome  

E-Print Network [OSTI]

Skeleton. In Bone Loss and Osteoporosis: An AnthropologicalThe radiological diagnosis of osteoporosis: A new approach.170. Birnbaum, E. 1992. Osteoporosis: A Summary of Recent

Beauchesne, Patrick Denis

2012-01-01T23:59:59.000Z

144

allowing normal bone: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

assays. Correlations of fluoride levels between normal bone near the Nancy Medina; Chester W. Douglass; Gary M. Whitford; Robert N. Hoover; Thomas R. Fears 6 Differential...

145

A STUDY OF ULTRASONIC WAVE PROPAGATION IN BONES  

E-Print Network [OSTI]

Editions Technip, Paris, 1987. Buchanan J., Gilbert R., and Khashanah K. Deter- mination of the parameters of cancellous bone using low frequency acoustic ...

zyserman

146

Quantity and Quality of Trabecular Bone in the Femur Are Enhanced by a Strongly Anabolic, Noninvasive  

E-Print Network [OSTI]

serve as the basis for a biomechanically based intervention for osteoporosis. To evaluate intervention for osteoporosis. (J Bone Miner Res 2002;17:349­357) Key words: osteoporosis, osteogenic, anabolic, bone formation, bone quality, osteogenic INTRODUCTION OSTEOPOROSIS, A disease characterized

147

Protocadherin-7 induces bone metastasis of breast cancer  

SciTech Connect (OSTI)

Highlights: •PCDH7 is overexpression in high bone metastatic MDA-MB-231 cells. •PCDH7 is up-regulation in bone metastatic breast cancer tissues. •Suppression of PCDH7 inhibits cell proliferation, migration, and invasion in vitro. •PCDH7 induces breast cancer bone metastasis in vivo. -- Abstract: Breast cancer had a propensity to metastasize to bone, resulting in serious skeletal complications associated with poor outcome. Previous study showed that Protocadherin-7 (PCDH7) play an important role in brain metastatic breast cancer, however, the role of PCDH7 in bone metastatic breast cancer has never been explored. In the present study, we found that PCDH7 expression was up-regulation in bone metastatic breast cancer tissues by real-time PCR and immunohistochemistry assays. Furthermore, suppression of PCDH7 inhibits breast cancer cell proliferation, migration, and invasion in vitro by MTT, scratch, and transwell assays. Most importantly, overexpression of PCDH7 promotes breast cancer cell proliferation and invasion in vitro, and formation of bone metastasis in vivo. These data provide an important insight into the role of PCDH7 in bone metastasis of breast cancer.

Li, Ai-Min [Department of Orthopedics, The 5th Central Hospital of Tianjin, Tianjin (China)] [Department of Orthopedics, The 5th Central Hospital of Tianjin, Tianjin (China); Tian, Ai-Xian [Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)] [Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Zhang, Rui-Xue [Department of Clinical Laboratory Diagnosis, Tianjin Medical University, Tianjin (China)] [Department of Clinical Laboratory Diagnosis, Tianjin Medical University, Tianjin (China); Ge, Jie [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Sun, Xuan [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)] [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Cao, Xu-Chen, E-mail: caoxuch@126.com [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)

2013-07-05T23:59:59.000Z

148

Therapeutic Agents for the Prevention and Restoration of Bone Mass  

E-Print Network [OSTI]

osteoporosis-related bone loss. According to the National Osteoporosis Foundation, osteoporosis is a major osteoporosis Advantages · Selectively blocks osteoclastic bone resorption by a novel mechanism, providing in post-menopausal women. This ultimately leads to fractures resulting from minimal falls and accidents

Slatton, Clint

149

E-Print Network 3.0 - arthritis bone marrow Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

stem cells (MSCs; also Summary: -derived MSC; AT, adipose tissue; BM, bone marrow; CIA, collagen- induced arthritis; HGF, hepatocyte growth... in the bone marrow (BM) 2 but...

150

E-Print Network 3.0 - adam12-s stimulates bone Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and computer... design (dimensions, profile shape and material properties) on the load sharing with adjacent bone... and consequent bone resorption was tested, using a set of...

151

E-Print Network 3.0 - antibiotic-loaded bone grafts Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

-based implants for bone reconstruction and repair. We have developed HA-coated carbon-fiber polymer composites... that match bone's elastic modulus and show advantageous in vitro...

152

E-Print Network 3.0 - augmenttm bone graft Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

-based implants for bone reconstruction and repair. We have developed HA-coated carbon-fiber polymer composites... that match bone's elastic modulus and show advantageous in vitro...

153

E-Print Network 3.0 - aspirate bone graft Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

-based implants for bone reconstruction and repair. We have developed HA-coated carbon-fiber polymer composites... that match bone's elastic modulus and show advantageous in...

154

Novel Techniques for High-Resolution Functional Imaging of Trabecular Bone  

E-Print Network [OSTI]

associated with osteoporosis (1, 2). Osteoporosis results in bone loss and deterioration in trabecular a primary endpoint in osteoporosis diagnosis and monitoring. Where strong correlations between bone density

Fygenson, Deborah Kuchnir

155

Bone Growth, Maintenance and Loss in the Neolithic Community of Çatalhöyük, Turkey: Preliminary Results  

E-Print Network [OSTI]

Interpreting Bone Loss and Osteoporosis in Past Populations.2005. How many women have osteoporosis? Journal of Bone and1987. Postmenopausal osteoporosis: single screening method

Agarwal, Sabrina; Glencross, Bonnie; Beauchesne, Patrick

2011-01-01T23:59:59.000Z

156

E-Print Network 3.0 - artificial bone substitute Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales Summary: to its biomedical significance, bone has been used...

157

E-Print Network 3.0 - affecting bone mineral Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of remodeling on the mineralization of bone... of therapies that reduce the risk of fracture, increase bone mineral density or change the biochemical markers... mass and...

158

E-Print Network 3.0 - activity bone mineral Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of remodeling on the mineralization of bone... of therapies that reduce the risk of fracture, increase bone mineral density or change the biochemical markers... mass and...

159

E-Print Network 3.0 - adsorbed bone sialoprotein Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mass Philipp J. Thurner a... 2010 Edited by: D. Burr Keywords: Osteopontin Rodent Fracture toughness Bone matrix properties... Mineralization The ability of bone to resist...

160

E-Print Network 3.0 - anorganic bone clinical Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

predictor of bone mass... formation from bone marrow progenitors. Journal of ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

E-Print Network 3.0 - adverse events bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by Explorit Topic List Advanced Search Sample search results for: adverse events bone Page: << < 1 2 3 4 5 > >> 1 Mechanoregulated bone adaptation in osteoarthritis This...

162

WOMEN'S GLOBAL HEALTH INSTITUTE NUTR59000/BMS59800: WOMEN'SHEALTH:BONE  

E-Print Network [OSTI]

/remodeling, mechanics;Tools of assessment Epidemiology of osteoporosis Development of peak bone mass ­ nutrition/exercise Adult Bone: Women's reproductive choices ­ oral contraceptives, pregnancy, lactation Menopause: Biology

163

E-Print Network 3.0 - alveolar bone defects Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Wang's group aims to understand how mechanical forces... influence solute and fluid transport in bone. The knowledge helps our understanding of normal bone... adaptation and...

164

Differences in Bone Quality between High versus Low Turnover Renal Osteodystrophy  

SciTech Connect (OSTI)

Abnormal bone turnover is common in chronic kidney disease (CKD), but its effects on bone quality remain unclear. This study sought to quantify the relationship between abnormal bone turnover and bone quality. Iliac crest bone biopsies were obtained from CKD-5 patients on dialysis with low (n=18) or high (n=17) turnover, and from volunteers (n=12) with normal turnover and normal kidney function. Histomorphometric methods were used to quantify the microstructural parameters; Fourier transform infrared spectroscopy and nanoindentation were used to quantify the material and mechanical properties in bone. Reduced mineral-to-matrix ratio, mineral crystal size, stiffness and hardness were observed in bone with high turnover compared to bone with normal or low turnover. Decreased cancellous bone volume and trabecular thickness were seen in bone with low turnover compared to bone with normal or high turnover. Bone quality, as defined by its microstructural, material, and mechanical properties, is related to bone turnover. These data suggest that turnover related alterations in bone quality may contribute to the known diminished mechanical competence of bone in CKD patients, albeit from different mechanisms for bone with high (material abnormality) vs. low (microstructural alteration) turnover. The present findings suggest that improved treatments for renal osteodystrophy should seek to avoid low or high bone turnover and aim for turnover rates as close to normal as possible.

Porter, Daniel S. [University of Kentucky, Lexington; Pienkowski, David [University of Kentucky, Lexington; Faugere, Marie-Claude [Albert B. Chandler Medical Center; Malluche, Hartmut H. [Albert B. Chandler Medical Center

2012-01-01T23:59:59.000Z

165

Modeling LGN Responses during Free-Viewing: A Possible Role of Microscopic Eye Movements in the Refinement of Cortical  

E-Print Network [OSTI]

in the Refinement of Cortical Orientation Selectivity Michele Rucci,1 Gerald M. Edelman,2 and Jonathan Wray2 1 affect the refinement of orientation tuning in the presence of a Hebbian scheme of synaptic plasticity an important role for the eye movements occurring during fixation in the refinement of orientation selectivity

Rucci, Michele

166

Relation between hydrogen isotopic ratios of bone collagen and rain  

SciTech Connect (OSTI)

The hydrogen isotopic value ([delta]D) of deer bone collagen is related to both [delta]D of rain during the growing season and growing season relative humidity (RH). With correction for the effects of RH, bone [delta]D is related to growing season rain [delta]D in a simple manner with a slope of 1.0. This indicates that, with RH correction, there are no additional sources of bias in the [delta]D of bone due to unaccounted for biologic or climatic effects. Due to a low sensitivity of bone [delta]D to RH effects, both yearly and growing season rain [delta]D can be estimated with considerable accuracy (R = 0.97 and R = 0.96) from bone collagen [delta]D and [delta][sup 15]N. Here, [delta][sup 15]N is used to correct bone [delta]D for the effects of RH. From these estimates of rain [delta]D, it may then be possible to evaluate temperature since the [delta]D of rain primarily reflects local temperature. Therefore, the measurement of bone collagen [delta]D has good potential for evaluating paleoclimates.

Cormie, A.B.; Schwarcz, H.P. (McMaster Univ., Hamilton, Ontario (Canada)); Gray, J. (Univ. of Alberta, Edmonton (Canada))

1994-01-01T23:59:59.000Z

167

The effects of low environmental cadmium exposure on bone density  

SciTech Connect (OSTI)

Recent epidemiological data indicate that low environmental exposure to cadmium, as shown by cadmium body burden (Cd-U), is associated with renal dysfunction as well as an increased risk of cadmium-induced bone disorders. The present study was designed to assess the effects of low environmental cadmium exposure, at the level sufficient to induce kidney damage, on bone metabolism and mineral density (BMD). The project was conducted in the area contaminated with cadmium, nearby a zinc smelter located in the region of Poland where heavy industry prevails. The study population comprised 170 women (mean age=39.7; 18-70 years) and 100 men (mean age=31.9; 18-76 years). Urinary and blood cadmium and the markers of renal tubular dysfunction ({beta}{sub 2}M-U RBP, NAG), glomerular dysfunction (Alb-U and {beta}{sub 2}M-S) and bone metabolism markers (BAP-S, CTX-S) as well as forearm BMD, were measured. The results of this study based on simple dose-effect analysis showed the relationship between increasing cadmium concentrations and an increased excretion of renal dysfunction markers and decreasing bone density. However, the results of the multivariate analysis did not indicate the association between exposure to cadmium and decrease in bone density. They showed that the most important factors that have impact on bone density are body weight and age in the female subjects and body weight and calcium excretion in males. Our investigation revealed that the excretion of low molecular weight proteins occurred at a lower level of cadmium exposure than the possible loss of bone mass. It seems that renal tubular markers are the most sensitive and significant indicators of early health effects of cadmium intoxication in the general population. The correlation of urinary cadmium concentration with markers of kidney dysfunction was observed in the absence of significant correlations with bone effects. Our findings did not indicate any effects of environmental cadmium exposure on bone density.

Trzcinka-Ochocka, M., E-mail: ochocka@imp.lodz.pl [Department of Chemical Hazards, Laboratory of Biomonitoring, Nofer Institute of Occupational Medicine, Lodz (Poland); Jakubowski, M. [Department of Chemical Hazards, Laboratory of Biomonitoring, Nofer Institute of Occupational Medicine, Lodz (Poland)] [Department of Chemical Hazards, Laboratory of Biomonitoring, Nofer Institute of Occupational Medicine, Lodz (Poland); Szymczak, W. [Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz (Poland) [Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz (Poland); Insitute of Psychology, University of Lodz (Poland); Janasik, B.; Brodzka, R. [Department of Chemical Hazards, Laboratory of Biomonitoring, Nofer Institute of Occupational Medicine, Lodz (Poland)] [Department of Chemical Hazards, Laboratory of Biomonitoring, Nofer Institute of Occupational Medicine, Lodz (Poland)

2010-04-15T23:59:59.000Z

168

Bone density and geometry in juvenile racehorses fed differing amounts of minerals  

E-Print Network [OSTI]

designed as low, moderate, moderately high and high. Radiographs of the third metacarpal (MCIII) were taken on day 0, 28, 60, 92 and 124 to evaluate change in bone density and bone geometry. Bone density was expressed as radiographic bone aluminum...

Nolan, Meghan Muire

2002-01-01T23:59:59.000Z

169

Patients with Patellofemoral Pain Exhibit Elevated Bone Metabolic Activity at the Patellofemoral Joint  

E-Print Network [OSTI]

for bone mineral,10 are injected intravenously. The 18 F fluoride ions exchange with hydroxl ions in bone and pain. Technetium-99m hydroxymethylene diphosphonate (Tc-99m MDP) bone scintigraphy previ- ously bone metabolic activity. In this imaging technique, 18 F fluoride ions, which have a high affinity

Delp, Scott

170

Patients with Patellofemoral Pain Exhibit Elevated Bone Metabolic Activity at the Patellofemoral Joint  

E-Print Network [OSTI]

for bone mineral,10 are injected intravenously. The 18 F fluoride ions exchange with hydroxl ions in bone stress and pain. Technetium-99m hydroxymethylene diphosphonate (Tc-99m MDP) bone scintigraphy previ bone metabolic activity. In this imaging technique, 18 F fluoride ions, which have a high affinity

Delp, Scott

171

Evaluation of radionuclide bone-imaging for the early detection of sepsis in a model of equine neonatal osteomyelitis  

E-Print Network [OSTI]

method of detecting bone abnormalities. The two main factors determining the degree of radiopharmaceutical uptake in bones, and thereby assessing the functional integrity of bone, have been identified as bone blood flow and bone turnover rates.... The resultant infection and induced metabolic changes should produce a positive Technetium-99m MDP ( Tc-MDP) 99m bone scan, a positive scan using Indium-111-oxine labeled leukocytes and radiographic changes characterized by decreased bone density . Seven...

Taylor, James Rutledge

1986-01-01T23:59:59.000Z

172

affects bone tissue: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

hepatotoxicity is considered to be the cause of the diffuse liver uptake of 99m Tc-MDP. The mechanism of extraskeletal uptake of bone-seeking radiopharmaceuticals in...

173

acute bone marrow: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

hepatotoxicity is considered to be the cause of the diffuse liver uptake of 99m Tc-MDP. The mechanism of extraskeletal uptake of bone-seeking radiopharmaceuticals in...

174

abnormal bone growth: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

uptake of 99m Tc-MDP. The mechanism of extraskeletal uptake of bone-seeking radiopharmaceuticals in damaged, inflamed, neoplastic or necrotic tissues may be due to dystrophic...

175

acute bone crises: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

uptake of 99m Tc-MDP. The mechanism of extraskeletal uptake of bone-seeking radiopharmaceuticals in damaged, inflamed, neoplastic or necrotic tissues may be due to dystrophic...

176

abnormal bone development: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

uptake of 99m Tc-MDP. The mechanism of extraskeletal uptake of bone-seeking radiopharmaceuticals in damaged, inflamed, neoplastic or necrotic tissues may be due to dystrophic...

177

absorptiometry bone densitometer: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

hepatotoxicity is considered to be the cause of the diffuse liver uptake of 99m Tc-MDP. The mechanism of extraskeletal uptake of bone-seeking radiopharmaceuticals in...

178

alveolar bone cells: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

uptake of 99m Tc-MDP. The mechanism of extraskeletal uptake of bone-seeking radiopharmaceuticals in damaged, inflamed, neoplastic or necrotic tissues may be due to dystrophic...

179

acute bone infarcts: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

uptake of 99m Tc-MDP. The mechanism of extraskeletal uptake of bone-seeking radiopharmaceuticals in damaged, inflamed, neoplastic or necrotic tissues may be due to dystrophic...

180

acellular bone explants: Topics by E-print Network  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

hepatotoxicity is considered to be the cause of the diffuse liver uptake of 99m Tc-MDP. The mechanism of extraskeletal uptake of bone-seeking radiopharmaceuticals in...

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

ORIGINAL ARTICLE Effects of sequential osteoporosis treatments on trabecular bone  

E-Print Network [OSTI]

ORIGINAL ARTICLE Effects of sequential osteoporosis treatments on trabecular bone in adult rats /Accepted: 3 September 2013 /Published online: 11 April 2014 # International Osteoporosis Foundation and National Osteoporosis Foundation 2014 Abstract Summary We used an osteopenic adult ovariectomized (OVX) rat

Ritchie, Robert

182

On the Mechanistic Origins of Toughness in Bone  

E-Print Network [OSTI]

One of the most intriguing protein materials found in nature is bone, a material composed of assemblies of tropocollagen molecules and tiny hydroxyapatite mineral crystals that form an extremely tough, yet lightweight, ...

Launey, Maximilien E.

183

Compact biomedical pulsed signal generator for bone tissue stimulation  

DOE Patents [OSTI]

An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

Kronberg, J.W.

1993-06-08T23:59:59.000Z

184

Compact biomedical pulsed signal generator for bone tissue stimulation  

DOE Patents [OSTI]

An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

Kronberg, James W. (108 Independent Blvd., Aiken, SC 29801)

1993-01-01T23:59:59.000Z

185

Trabecular bone dosimetry using a Monte Carlo code  

E-Print Network [OSTI]

The nuclear medicine community needs radiation ~ dose estimates to patients who are administered radiopharmaceuticals for therapy or diagnosis. These estimates should be as accurate as possible for any organ, and especially for the bone since the bone... of Nuclear Medicine formed a committee to fulfill the needs of the nuclear medicine community to determine the radiation absorbed dose to patients who are athninistered radiopharmaceuticals. The objectives of the Medical Internal Radiation Dose Committee...

Zuzarte de Mendonca, Anne

1993-01-01T23:59:59.000Z

186

X-band EPR imaging as a tool for gradient dose reconstruction in irradiated bones  

SciTech Connect (OSTI)

Purpose: Various tools are currently available for dose reconstruction in individuals after accidental exposure to ionizing radiation. Among the available biological analyses, Monte Carlo simulations, and biophysical methods, such as electron paramagnetic resonance (EPR), the latter has proved its usefulness for retrospective dosimetry. Although EPR spectroscopy is probably the most sensitive technique, it does not provide spatial dosimetric data. This information is, however, highly desirable when steep dose gradient irradiations are involved. The purpose of this work was to explore the possibilities of EPR imaging (EPRI) for spatial dose reconstruction in irradiated biological material. Methods: X-band EPRI was used to reconstruct ex vivo the relative dose distribution in human bone samples and hydroxyapatite phantoms after irradiation with brachytherapy seeds or x rays. Three situations were investigated: Homogeneous, stepwise gradient, and continuous gradient irradiation. Results: EPRI gave a faithful relative spin density distribution in bone samples and in hydroxyapatite phantoms. Measured dose ratios were in close agreement with the actual delivered dose ratios. EPRI was able to distinguish the dose gradients induced by two different sources ({sup 125}I and {sup 192}Ir). However, the measured spatial resolution of the system was 1.9 mm and this appeared to be a limiting factor. The method could be improved by using new signal postprocessing strategies. Conclusions: This study demonstrates that EPRI can be used to assess the regional relative dose distribution in irradiated bone samples. The method is currently applicable to ex vivo measurements of small size samples with low variation in tissue density but is likely to be adapted for in vivo application using L-band EPRI.

Leveque, Philippe; Godechal, Quentin; Bol, Anne; Trompier, Francois; Gallez, Bernard [Biomedical Magnetic Resonance Unit, Universite catholique de Louvain, B-1200 Brussels (Belgium); Molecular Imaging and Experimental Radiotherapy Unit, Universite catholique de Louvain, B-1200 Brussels (Belgium); Institut de Surete Nucleaire et de Radioprotection, F-92262 Fontenay-aux-Roses (France); Biomedical Magnetic Resonance Unit, Universite catholique de Louvain, B-1200 Brussels (Belgium)

2009-09-15T23:59:59.000Z

187

Histologic Comparison of Regenerate Bone Produced from Dentate Versus Edentulous Transport Discs in Bone Transport Distraction Osteogenesis  

E-Print Network [OSTI]

i HISTOLOGIC COMPARISON OF REGENERATE BONE PRODUCED FROM DENTATE VERSUS EDENTULOUS TRANSPORT DISCS IN BONE TRANSPORT DISTRACTION OSTEOGENESIS A Thesis by CARLOS SEVILLA GAITÁN Submitted to The Office of Graduate and Professional Studies... Paul Dechow Head of Department, William W. Nagy December 2013 Major Subject: Oral Biology Copyright 2013 Carlos Sevilla Gaitan ii ABSTRACT Purpose: The purpose of this research was to quantify the number of blood vessels...

Sevilla Gaitan, Carlos

2013-12-10T23:59:59.000Z

188

The effect of iron chloride and glutamate on glutamine synthetase activity in primary cultured rat cortical astrocytes: a model for epileptic induction  

E-Print Network [OSTI]

THE EFFECT OF IRON CHLORIDE AND GLUTAMATE ON GLUTAMINE SYNTHETASE ACTIVITY IN PRIMARY CULTURED RAT CORTICAL ASTROCYTES: A MODEL POR EPILEPTIC INDUCTION A Thesis by JULIE ANN ROBERTS Submitted to the Graduate College of Texas ARM University... in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE December 1986 Major Subject: Veterinary Anatomy THE EFFECT OF IRON CHLORIDE AND GLUTAMATE ON GLUTAMINE SYNTHETASE ACTIVITY IN PRIMARY CULTURED RAT CORTICAL ASTROCYTES: A...

Roberts, Julie Ann

1986-01-01T23:59:59.000Z

189

Opiate activity in the rat prefrontal cortex: modulation of ventral tegmental area dopaminergic influence on cortical efferent neurons  

E-Print Network [OSTI]

OPIATE ACTIVITY IN THE RAT PREFRONTAL CORTEX: MODULATION OF VENTRAL TEGMENTAL AREA DOPAMINERGIC INFLUENCE ON CORTICAL EFFERENT NEURONS A Thesis by JOHN STEVEN ST. MARY Submitted to the Graduate College of Texas A&M University in partial... Thesis by JOHN STEVEN ST. MARY Approved as to style and content by: Steven Peterson (Chairman of Committee) Robert Matthews (- '" j'pj") Ger a ((~Fe g (Mem er) George Chion (Member) December 1986 ABSTRACT Opiate Activity in the Rat...

St. Mary, John Steven

1986-01-01T23:59:59.000Z

190

GLIA 46:18–27 (2004) Potassium Attenuates Zinc-Induced Death of Cultured Cortical Astrocytes  

E-Print Network [OSTI]

zinc toxicity; neurons; astrocytes; intracellular zinc; depolarization; zinc accumulation Transient global ischemia induces CA1 hippocampal neuronal death without astrocyte death, perhaps mediated in part by the toxic translocation of zinc from presynaptic terminals to postsynaptic neurons. We tested the hypothesis that cellular depolarization, which occurs in the ischemic brain due to increased extracellular potassium and energy failure, might contribute to astrocyte resistance to zinc-induced death. We previously reported that neurons in mixed cortical neuronal-astrocyte cultures were more vulnerable to a 5–15-min exposure to Zn 2 ? than astrocytes in the same cultures. In the present report, we show that (1) neurons in isolation or in conjunction with astrocytes were 2–3-fold more sensitive to a 15-min nondepolarizing Zn 2 ? exposure than are glia; (2) KCl-induced depolarization attenuated glial vulnerability to zinc toxicity but potentiated neuronal vulnerability to zinc toxicity; (3) Zn 2 ?-induced glial death was attenuated by T-type Ca 2 ? channel blockade, as well as compounds that increase NAD ?

Christian T. Sheline; Toshihiro Takata; Howard Ying; Lorella M. T. Canzoniero; Aizhen Yang; Shan Ping Yu; Dennis; W. Choi; Key Words

191

Rapid Communication Delayed Application of Aurintricarboxylic Acid Reduces Glutamate-Induced Cortical Neuronal  

E-Print Network [OSTI]

The non-specific endonuclease inhibitor, aurintricarboxylic acid (ATA), attenuated glutamate-induced destruction of cultured cortical neurons. In part, this protective effect likely reflected the ability of ATA to produce a slowly developing block of N-methyl-D-aspartate receptor-mediated inward whole cell current or increase in intracellular free Ca2+. However, ATA also attenuated a high K+-induced increase in intracellular free Ca2+ in the presence of D-aminophosphonovalerate, suggesting that ATA may have a more general effect on Ca2+ homeostasis. In addition, ATA attenuated glutamate neurotoxicity even if added up to 2 hr after completion of glutamate exposure, a time when glutamate antagonists or lipid peroxidation inhibitors are no longer neuroprotective. Involvement of apoptosis in this excitotoxic death is unlikely, as Southern blotting of genomic DNA revealed no evidence of fragmentation, and death was not prevented by inhibitors of RNA or protein synthesis. Most likely, ATA interferes with some key downstream consequences of excitotoxic glutamate receptor overactivation. 0 1994 Wiley-Liss, Inc. Key words: delayed rescue, apoptosis, calcium homeostasis

C. A. Csernansky; L. M. T. Canzoniero; S. L. Sensi; S. P. Yu; D. W. Choi

192

Adolescents with prenatal cocaine exposure show subtle alterations in striatal surface morphology and frontal cortical volumes  

E-Print Network [OSTI]

of prenatal cocaine exposure (PCE) in humans have yieldedin adolescents with PCE compared to control participants.significantly differ between PCE participants and controls.

2012-01-01T23:59:59.000Z

193

Common variants in the region around Osterix are associated with bone mineral density and growth in childhood  

E-Print Network [OSTI]

Peak bone mass achieved in adolescence is a determinant of bone mass in later life. In order to identify genetic variants affecting bone mineral density (BMD), we performed a genome-wide association study of BMD and related ...

Peltonen, Leena

194

Bone breakage in laying hens as affected by dietary supplements  

E-Print Network [OSTI]

BONE BREAKAGE IN LAYING HENS AS AFFECTED BY DIETARY SUPPLEMENTS A Thesis by DAVID JOE MOORE Submitted to the Graduate College of Texas Al!M University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE August 1975... Major Subject: Poultry Science (Physiology) BONE BREAKAGE IN LAYING HENS AS AFFECTED BY DIETARY SUPPLEMENTS A Thesis by DAVID JOE MOORE Approved as to style and content by: Chairman of Comm' ee ad o Department) Member Member '7 I ls&wr g ~, /0...

Moore, David Joe

1975-01-01T23:59:59.000Z

195

Detection of bone disease in dogs by radioisotope scanning  

E-Print Network [OSTI]

DETECTION OZ BONE DISEASE IN DOGS BY RADIOISOTOPE SCANNING A Thesis EARL LOUIS MORRIS Submitted to the Graduate College of Texas A8cM University in partial fulfillment of' the requirement for the degree of MASTER OP SCIENCE May 1971 Major...' Bone Disease in Dogs by Radioisotope Scanning. (May 1971) Earl Louis Morris, B. S. , Texas Ad:I University; B. S. , Texas MM University; D. V. M. , Texas A8cM University; Directed by: Dan Eightower, D. V. M. The use of radioisotope scintiscanning...

Morris, Earl Louis

1971-01-01T23:59:59.000Z

196

Effects of dietary silicon on bone characteristics of poultry  

E-Print Network [OSTI]

EFFECTS OF D ETARY SILICON GN BONE CNARACTERISTICS OF POULTRY A Thesis James Edward Plyler Submitted. to tl. e Graduate College ot Texas ASM University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE August 1977... Major Subject. : Poultry Science L'FFECT OF DI TARY. SILICON QN BONE CEARACTER1STICS OF POULTPY A Thesis James Edward Plyier Approued as to style and content by. (Chairman of omm' tee) (Head of Dep tment) (Mem e ) (Mem. er ) gC~ r? (Membe...

Plyler, James Edward

1977-01-01T23:59:59.000Z

197

E-Print Network 3.0 - alveolar bone quality Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

< 1 2 3 4 5 > >> Page: << < 1 2 3 4 5 > >> 61 The Influence of Bone Volume Fraction and Ash Fraction on Bone Strength and Modulus Summary: assessment of the long-term effects of...

198

Bone Canonical WNT/B-Catenin Signaling in Models of Reduced Microgravity  

E-Print Network [OSTI]

translates into molecular osteogenic signals in bone cells is unknown. Radiation exposure is another potent inducer of bone loss, namely observed on Earth in the clinical setting following radiotherapy procedures. It is expected that long duration space...

Macias, Brandon 1979-

2012-10-25T23:59:59.000Z

199

Impact of Omega-3 Polyunsaturated Fatty Acids on Bone Adaptations to Simulated Resistance Training  

E-Print Network [OSTI]

properties of proximal tibia were measured using in vivo peripheral quantitative CT. Bone formation rate was quantified on the periosteal the surface by standard bone histomorphometry after intraperitoneal injections of calcein. There was a significant main...

Camp, Kaleigh Ann

2013-04-30T23:59:59.000Z

200

E-Print Network 3.0 - autotaxin controls bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

controls bone Search Powered by Explorit Topic List Advanced Search Sample search results for: autotaxin controls bone Page: << < 1 2 3 4 5 > >> 1 MCB 02419-05 Revised Autotaxin, a...

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

E-Print Network 3.0 - air bone particles Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2 3 4 5 > >> 1 Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone Summary: of trabecular bone Georg E. Fantnera,*, Henrik...

202

Apatite-polymer composites for the controlled delivery of bone morphogenetic proteins  

E-Print Network [OSTI]

Current treatment of bone defects due to trauma, cancer, or degenerative spine diseases involves the implantation of a bone graft. Autografts, which are harvested from the patient's own body, are associated with problems ...

Yong, Tseh-Hwan

2005-01-01T23:59:59.000Z

203

E-Print Network 3.0 - attenuates bone cancer Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cancer Search Powered by Explorit Topic List Advanced Search Sample search results for: attenuates bone cancer Page: << < 1 2 3 4 5 > >> 1 Questions and Answers About Bone Cancer...

204

Methods for identifying cancellous bone specimen location and size for the Reduced Platen Compression Test  

E-Print Network [OSTI]

, and stimuli on the skeleton and its ability to perform these everyday functions. The current state of bone testing is focused on understanding the mechanical properties of bone through use of traditional mechanical testing procedures such as three point...

Cowen, Kyle Ray

2013-02-22T23:59:59.000Z

205

Localization of Cortical Phase and Amplitude Dynamics during Visual Working Memory Encoding and Retention  

E-Print Network [OSTI]

Several studies show that the amplitudes of human brain oscillations are modulated during the performance of visual working memory (VWM) tasks in a load-dependent manner. Less is known about the dynamics and identities of ...

Palva, Satu

206

A Graph-based Approach for Computational Model of Bone Microstructure  

E-Print Network [OSTI]

azhang@buffalo.edu ABSTRACT Osteoporosis, a condition in which bones become fragile and more likely bone due to osteoporosis. The diagnosis of osteoporosis is commonly done by tests that measure for the diagnosis of osteoporosis are limited due to the lack of good measurements of bone quality. In this paper

Buffalo, State University of New York

207

A method for calibration of bone driver transducers to measure the mastoid impedance Reggie Weecea  

E-Print Network [OSTI]

bone vibrator transducers for clinical measurements, the transfer of energy from the bone driver by known masses. This absolute calibration is based upon a circuit model of the driver, describing specialized equipment not available in the clinic, and a refined bone driver circuit model is proposed

Allen, Jont

208

Human Ecology Human ecology Research  

E-Print Network [OSTI]

Channel, Latin America. STUDIOS Architecture. #12;HUMAN ECOLOGY · APRIL 2005 1 Lisa Staiano-Coico, Ph Frey spins a green alternative for textiles. Fibers from rapidly renewable materials

Wang, Z. Jane

209

Bone marrow stromal cells increase oligodendrogenesis after stroke  

E-Print Network [OSTI]

Bone marrow stromal cells increase oligodendrogenesis after stroke Jing Zhang1 , Yi Li1 , Zheng cell (BMSC) treatment of stroke in rats. Rats were subjected to the middle cerebral artery occlusion (MCAo). BMSCs have been shown to promote functional recovery post stroke. A therapeutic dose of BMSC (3

Cai, Long

210

Refinement of the $n-?$ and $p-?$ fish-bone potential  

E-Print Network [OSTI]

The fishbone potential of composite particles simulates the Pauli effect by nonlocal terms. We determine the $n-\\alpha$ and $p-\\alpha$ fish-bone potential by simultaneously fitting to the experimental phase shifts. We found that with a double Gaussian parametrization of the local potential can describe the $n-\\alpha$ and $p-\\alpha$ phase shifts for all partial waves.

E. Smith; R. Woodhouse; Z. Papp

2012-09-04T23:59:59.000Z

211

FSH Directly Regulates Bone Mass Yuanzhen Peng,1  

E-Print Network [OSTI]

.01.051 SUMMARY Postmenopausal osteoporosis, a global public health problem, has for decades been attributed and function. We suggest that high circulating FSH causes hypogonadal bone loss. INTRODUCTION Osteoporosis., 1993; Manolagas and Jilka, 1995). After menopause, resorption significantly exceeds formation

Wisconsin at Madison, University of

212

Invest in Your Bones Osteoporosis--The Silent Disease  

E-Print Network [OSTI]

Invest in Your Bones Osteoporosis--The Silent Disease Leaflet 2 Osteoporosis, a painful of State Health Services, 2008). Osteoporosis is preventable and/or treatable. Accordingly, osteoporosis of height, and chronic back pain. Hip fracture, the most serious consequence of osteoporosis, threatens one

213

Design and Control of a Bio-Inspired Human-Friendly Robot  

E-Print Network [OSTI]

with small electrical actuators, human-bone-inspired robotic links, and newly designed distributed compact, manufacturing and entertainment. A major challenge in such applications is safety: How can robots performance have included relocating the actuators to the base and powering the joints with cables[9, 4

Park, Yong-Lae

214

On the fracture of human dentin: Is it stress-or strain-controlled?  

E-Print Network [OSTI]

On the fracture of human dentin: Is it stress- or strain-controlled? R. K. Nalla,1 J. H. Kinney,2 R information in archival literature that can be usefully used to model such fracture. In fact, although the fracture event in dentin, akin to other mineralized tissues like bone, is widely believed to be locally

Ritchie, Robert

215

Nukbone® promotes proliferation and osteoblastic differentiation of mesenchymal stem cells from human amniotic membrane  

SciTech Connect (OSTI)

Highlights: •Nukbone showed to be a good scaffold for adhesion, proliferation and differentiation of stem cells. •Nukbone induced osteoblastic differentiation of human mesenchymal stem cells. •Results showed that Nukbone offer an excellent option for bone tissue regeneration due to properties. -- Abstract: Bovine bone matrix Nukbone® (NKB) is an osseous tissue-engineering biomaterial that retains its mineral and organic phases and its natural bone topography and has been used as a xenoimplant for bone regeneration in clinics. There are not studies regarding its influence of the NKB in the behavior of cells during the repairing processes. The aim of this research is to demonstrate that NKB has an osteoinductive effect in human mesenchymal stem cells from amniotic membrane (AM-hMSCs). Results indicated that NKB favors the AM-hMSCs adhesion and proliferation up to 7 days in culture as shown by the scanning electron microscopy and proliferation measures using an alamarBlue assay. Furthermore, as demonstrated by reverse transcriptase polymerase chain reaction, it was detected that two gene expression markers of osteoblastic differentiation: the core binding factor and osteocalcin were higher for AM-hMSCs co-cultured with NKB in comparison with cultivated cells in absence of the biomaterial. As the results indicate, NKB possess the capability for inducing successfully the osteoblastic differentiation of AM-hMSC, so that, NKB is an excellent xenoimplant option for repairing bone tissue defects.

Rodríguez-Fuentes, Nayeli; Rodríguez-Hernández, Ana G. [Depto. Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510 (Mexico)] [Depto. Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510 (Mexico); Enríquez-Jiménez, Juana [Depto. Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), México City 14000 (Mexico)] [Depto. Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), México City 14000 (Mexico); Alcántara-Quintana, Luz E. [Subd. de Investigación, Centro Nacional de la Transfusión Sanguínea, Secretaria de Salud, Mexico City 07370 (Mexico)] [Subd. de Investigación, Centro Nacional de la Transfusión Sanguínea, Secretaria de Salud, Mexico City 07370 (Mexico); Fuentes-Mera, Lizeth [Depto. Biología Molecular e Histocompatibilidad, Hospital General “Dr. Manuel Gea González”, México City 4800 (Mexico)] [Depto. Biología Molecular e Histocompatibilidad, Hospital General “Dr. Manuel Gea González”, México City 4800 (Mexico); Piña-Barba, María C. [Depto. Materiales Metálicos y Cerámicos, Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México (UNAM), México City 04510 (Mexico)] [Depto. Materiales Metálicos y Cerámicos, Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México (UNAM), México City 04510 (Mexico); Zepeda-Rodríguez, Armando [Depto. Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México City 04510 (Mexico)] [Depto. Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México City 04510 (Mexico); and others

2013-05-10T23:59:59.000Z

216

A Neural Model of Motion Processing and Visual Navigation by Cortical Area MST  

E-Print Network [OSTI]

­95­1­0657). ¶Supported in part by the Air Force Office of Scientific Research (AFOSR F49620­92­J­0334) the Defense fields, spatial pooling of motion­sensitive signals, and subtractive extraretinal eye movement sig­ nals properties and psychophysical data about human navigation. Model cells match MSTd neuron responses to optic

Grossberg, Stephen

217

A Neural Model of Motion Processing and Visual Navigation by Cortical Area MST  

E-Print Network [OSTI]

-95-1-0657). ¶Supported in part by the Air Force Office of Scientific Research (AFOSR F49620-92-J-0334) the Defense fields, spatial pooling of motion-sensitive signals, and subtractive extraretinal eye movement sig- nals properties and psychophysical data about human navigation. Model cells match MSTd neuron responses to optic

Grossberg, Stephen

218

Research report Axon growth and recovery of function supported by human bone marrow  

E-Print Network [OSTI]

may be donor-dependent. Similarly, a battery of behavioral tests showed partial recovery in some would be readily obtainable, easy to expand and bank, and capable of surviving long enough to facilitate

Fischer, Itzhak

219

The effect of continuous infusion of human parathyroid hormone on bone architecture in female mice  

E-Print Network [OSTI]

This research sought to create an animal model of secondary hyperparathyroidism through continuous infusion of parathyroid hormone (PTH) in adult female mice, and to subsequently study the catabolic effects of PTH. Osmotic ...

Eisenberg, Rahel E. (Rahel Esther)

2009-01-01T23:59:59.000Z

220

The Ductility of Human Jaw Bone Attached to a Tooth | Stanford Synchrotron  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched Ferromagnetism in Layered NbS2 and NbSe2Different Impacts of SO2 and SO3

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

Identification of a hypoxic population of bone marrow cells  

SciTech Connect (OSTI)

A technique using collagenase has been devised to release and separate, with reproducibility, hematopoietic cells (HC) from various microenvironments of mouse femurs. HC were assayed by an in vitro gel culture technique used traditionally to score granulocyte-macrophage precursor cells (CFU-C). CFU-C which resided in the medullary cavity and endosteal regions were sensitive to ionizing radiation and resistant to misonidazole (MISO) cytotoxicity. CFU-C which resided within the compact bone were resistant to ionizing radiation and sensitive to the cytotoxic action of MISO. These results suggest that HC which reside in the bone are hypoxic and retain clonogenic potential. When animals were exposed to various treatments with MISO followed by myelotoxic doses of cyclophosphamide (CTX) or total body irradiation (TBI), the LD/sub 50/ of both agents was significantly reduced. This result suggests that a hypoxic component of HC could be important in the regenerative process within the marrow after such myelotoxic trauma.

Allalunis, M.J.; Chapman, J.D.; Turner, A.R.

1983-02-01T23:59:59.000Z

222

Exposure to cadmium and persistent organochlorine pollutants and its association with bone mineral density and markers of bone metabolism on postmenopausal women  

SciTech Connect (OSTI)

Environmental contaminants such as cadmium and persistent organochlorine pollutants have been proposed as risk factors of osteoporosis, and women may be at an increased risk. To assess associations between exposure to cadmium and two different POPs (2,2',4,4',5,5'-hexachlorobiphenyl CB-153, 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene p,p'-DDE), on one hand, and bone effects, on the other, in a population-based study among postmenopausal (60-70 years) Swedish women with biobanked blood samples. The study included 908 women and was designed to have a large contrast of bone mineral densities, measured with a single photon absorptiometry technique in the non-dominant forearm. Biochemical markers related to bone metabolism were analyzed in serum. Exposure assessment was based on cadmium concentrations in erythrocytes and serum concentrations of CB-153 and p,p'-DDE. Cadmium was negatively associated with bone mineral density and parathyroid hormone, positively with the marker of bone resorption. However, this association disappeared after adjustment for smoking. The major DDT metabolite (p,p'-DDE) was positively associated with bone mineral density, an association which remained after adjustment for confounders, but the effect was weak. There was no evidence that the estrogenic congener (CB-153) was associated with any of the bone markers. In conclusion, no convincing associations were observed between cadmium and POPs, on one hand, and bone metabolism markers and BMD, on the other.

Rignell-Hydbom, A., E-mail: anna.rignell-hydbom@med.lu.se [Department of Occupational and Environmental Medicine, Lund University (Sweden); Skerfving, S.; Lundh, T.; Lindh, C.H. [Department of Occupational and Environmental Medicine, Lund University (Sweden)] [Department of Occupational and Environmental Medicine, Lund University (Sweden); Elmstahl, S. [Division of Geriatric Medicine, Department of Health Sciences, Lund University, Malmue University Hospital (Sweden)] [Division of Geriatric Medicine, Department of Health Sciences, Lund University, Malmue University Hospital (Sweden); Bjellerup, P. [Center for Clinical Research, Uppsala University, Department of Clinical Chemistry, Vaesteras (Sweden)] [Center for Clinical Research, Uppsala University, Department of Clinical Chemistry, Vaesteras (Sweden); Juensson, B.A.G.; Struemberg, U. [Department of Occupational and Environmental Medicine, Lund University (Sweden)] [Department of Occupational and Environmental Medicine, Lund University (Sweden); Akesson, A. [Institute of Environmental Medicine, Karolinska Institutet, Stockholm (Sweden)] [Institute of Environmental Medicine, Karolinska Institutet, Stockholm (Sweden)

2009-11-15T23:59:59.000Z

223

Porous coatings from wire mesh for bone implants  

DOE Patents [OSTI]

A method of coating areas of bone implant elements and the resulting implant having a porous coating are described. Preselected surface areas are covered by a preform made from continuous woven lengths of wire. The preform is compressed and heated to assure that diffusion bonding occurs between the wire surfaces and between the surface boundaries of the implant element and the wire surfaces in contact with it. Porosity is achieved by control of the resulting voids between the bonded wire portions.

Sump, Kenneth R. (Richland, WA)

1986-01-01T23:59:59.000Z

224

A comparative histological study of fossil and recent bone tissues  

E-Print Network [OSTI]

? scopic inspection. A wet section, as viewed during trial grinding examinations, will appear more transparent than the dried, finished mount. Any of the standard laboratory abrasives, such as finely powdered carborundum, polishing alumina, or powdered... by hand with the bone section in direct contact with the revolving surface of a power-driven lap wheel. Finely powdered abrasive, such as carborundum or cleansing pov/der, is applied in the form of water paste to the wheel. Periodic inspection under a...

Enlow, Donald H.

1955-01-01T23:59:59.000Z

225

Automatic Feature-based Surface Mapping for Brain Cortices Fabien Vivodtzev1 David F. Wiley2 Lars Linsen3 James Jones2 Nina Amenta2  

E-Print Network [OSTI]

Automatic Feature-based Surface Mapping for Brain Cortices Fabien Vivodtzev1 David F. Wiley2 Lars effort is to develop technology for automatically transferring surface annotations from an atlas brain to a subject brain. While macroscopic regions of brain surfaces often correspond, the detailed surface geometry

Linsen, Lars

226

High resolution cortical thickness measurement from clinical CT data G.M. Treece, A.H. Gee, P.M. Mayhew and K.E.S. Poole  

E-Print Network [OSTI]

) methods of assessing hip structure, most notably with multi-detector computed tomography, MDCT (Bouxsein and technically limited by thresholding errors caused by relatively low resolution data sets. Ideally, we wouldHigh resolution cortical thickness measurement from clinical CT data G.M. Treece, A.H. Gee, P

Drummond, Tom

227

Plasticity in cortical neuron properties: Modeling the effects of an NMDA antagonist and a GABA agonist during visual deprivation  

E-Print Network [OSTI]

Infusion of a GABA agonist (Reiter & Stryker, 1988) and infusion of an NMDA receptor antagonist (Bear et al., 1990), in the primary visual cortex of kittens during monocular deprivation, shifts ocular dominance toward the closed eye, in the cortical region near the infusion site. This reverse ocular dominance shift has been previously modeled by variants of a covariance synaptic plasticity rule (Bear et al., 1990; Clothiaux et al., 1991; Miller et al., 1989; Reiter & Stryker, 1988). Kasamatsu et al. (1997, 1998) showed that infusion of an NMDA receptor antagonist in adult cat primary visual cortex changes ocular dominance distribution, reduces binocularity, and reduces orientation and direction selectivity. This paper presents a novel account of the effects of these pharmacological treatments, based on the EXIN synaptic plasticity rules (Marshall, 1995), which include both an instar afferent excitatory and an outstar lateral inhibitory rule. Functionally, the EXIN plasticity rules enha...

1998-01-01T23:59:59.000Z

228

Enhancement of Growth Performance and Bone Mineralization in Market Broilers through Dietary Enzymes  

E-Print Network [OSTI]

. In Experiment 1, a 35-day grow out trial was conducted to investigate the effect of three commercially available phytase enzymes on growth performance and bone mineralization in phosphorus deficient corn/soy based diets. Increasing the level of available... phosphorus (aP) in the control diets resulted in improved bird performance and bone ash data. The presence of dietary phytase in phosphorus deficient diets resulted in improvements in growth parameters and bone mineralization. Regression analysis...

Coppedge, Jacob Ryan

2012-02-14T23:59:59.000Z

229

Humboldtian Science, Creole Meteorology, and the Discovery of Human-Caused Climate Change in Northern South America  

E-Print Network [OSTI]

they are more fanatical." On the long walk south to Lima, Humboldt passed many signs of abandoned irrigation works, and he was especially struck by a barren field near the mouth of the Santa River covered with human bones, mummi­ fied body parts, and crushed...

Cushman, Gregory T.

2011-01-01T23:59:59.000Z

230

The X-ray attenuation characteristics and density of human calcaneal marrow do not change significantly during adulthood  

E-Print Network [OSTI]

The X-ray attenuation characteristics and density of human calcaneal marrow do not change be a significant source of error in measurements of bone density when using X-ray and ultrasound imaging modalities calcanei (28 males, 6 females, ages 17­65 years). The density and energy-dependent linear X-ray attenuation

Stanford University

231

E-Print Network 3.0 - alveolar bone loss Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

extended period of ossification. Most dermal bones begin ossification before ... Source: Smith, Kathleen K. - Department of Biology, Duke University Collection: Environmental...

232

E-Print Network 3.0 - anabolic bone hormone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in the Absence of Weight Bearing Can Enhance Trabecular Summary: two orders of magnitude smaller than those previously sug- gested, can be anabolic to bone when... ....

233

E-Print Network 3.0 - antler trabecular bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

for: antler trabecular bone Page: << < 1 2 3 4 5 > >> 1 Ndocrine relationships between rank -related behavior and antler growth in deer Ludek Bartos1 Summary: estradiol...

234

E-Print Network 3.0 - acetabular bone defect Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Journal of Arthroplasty Vol. 14 No. 7 1999 Case Report Summary: modular head and polyethylene liner. Bone defects were filled with morcellized allograft. Three months......

235

Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthma  

E-Print Network [OSTI]

risk of vertebral osteoporosis compared to men with noto identify patients with osteoporosis. Keywords Bone loss .associated with COPD, osteoporosis is believed to affect 36%

Dam, T.-T.; Harrison, S.; Fink, H. A.; Ramsdell, J.; Barrett-Connor, E.

2010-01-01T23:59:59.000Z

236

E-Print Network 3.0 - age-related bone loss Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Medicine 2 Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone Summary: . Modeling the mechanical behavior of vertebral...

237

E-Print Network 3.0 - animal bone collagen Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales Summary: of these cracks. 2005 Elsevier Ltd. All rights...

238

E-Print Network 3.0 - abnormally high bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by small intestine & promotes bone deposition... and Their Repairs stress fracture - break caused by abnormal ... Source: Morrell, Thomas E. - Department of Biology,...

239

E-Print Network 3.0 - affects bone parameters Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of bone quality will ultimately affect physical and morpho- logic parameters... fracture rates are most closely associated with ... Source: Rubin, Clinton T.- Department of...

240

E-Print Network 3.0 - absolutely normal bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

females (N 49). The data set consisted of bone biopsies from normal and vertebral fracture subjects... microradiographic studies of normal and oste- oporotic ... Source: Ecole...

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

E-Print Network 3.0 - anorganic bovine bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales Summary: , Hobbs LW, Spector M. The ultrastructure of...

242

E-Print Network 3.0 - abdomen bone growth Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

factor I and bone... . Genetic strategies for elucidat- ing insulin-like ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

243

E-Print Network 3.0 - attenuates bone cancer-induced Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

is incorrectly classified as bone when forming the linear attenuation coefficient image. We then investigate two... of attenuation coefficients of water (represent- ing...

244

E-Print Network 3.0 - agonist attenuates bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

unbalanced bone turnover that has been associated with a decreased number of ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

245

E-Print Network 3.0 - animal bone biomechanics Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: animal bone biomechanics Page: << < 1 2 3 4 5 > >> 1 MECHANICAL AND AEROSPACE ENGINEERING COLLOQUIUM SERIES Summary: fluorescent markers of...

246

A study to optimize the macroscopic structure of bone pylons used in direct skeletal attachment systems  

E-Print Network [OSTI]

studies, the direct chemical bonding of a material to bone has also received attention. Hench, et. al. (1971), introduced a bone-bonding calcia-phosphosilicate glass ceramic and included a theoretical model, based on in-viva studies in rat femurs... bone tissue. In this study, ceramics composed of CaO and A1203 were implanted in young adult rhesus monkeys with favorable results. Greenlee, et. al. (1972), and Greenlee and Beckham (1972) studied bone ingrowth into glass ceramics and reported good...

Trono, Ruben

1975-01-01T23:59:59.000Z

247

E-Print Network 3.0 - adult bone-marrow-derived mesenchymal Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of Washington at Seattle Collection: Biology and Medicine 34 Immobilized sonic hedgehog N-terminal signaling domain enhances differentiation of bone marrow-derived...

248

E-Print Network 3.0 - altered bone material Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

FRAMEWORKS FOR ENGINEERS Session 20.1 m: Musculoskeletal System -Bones Summary: architecture, and equally definite secondary alterations in their external confirmation" VI....

249

E-Print Network 3.0 - adverse bone effects Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Engineering, Bioinformatics, Database, Data Mining, and Multimedia Group Collection: Computer Technologies and Information Sciences 48 Bone marrow fat has brown adipose tissue...

250

E-Print Network 3.0 - asymptomatic local bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collection: Engineering ; Biology and Medicine 42 Science Highlight June 2010 Figure 1: Micro-CT (left) shows trabecular structure inside of bone. Transmission X-ray Summary: ....

251

E-Print Network 3.0 - affects trabecular bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

at different structural... bone, are ... Source: Gefen, Amit - Department of Biomedical Engineering, Tel Aviv University Collection: Engineering ; Biology and Medicine 2...

252

E-Print Network 3.0 - assess 3d bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Technologies and Information Sciences 2 Combining High-resolution Micro computed Tomography with Material Summary: : Quantification of connectivity in cancellous bone, with...

253

Engineering tubular bone using mesenchymal stem cell sheets and coral particles  

SciTech Connect (OSTI)

Highlights: • We developed a novel engineering strategy to solve the limitations of bone grafts. • We fabricated tubular constructs using cell sheets and coral particles. • The composite constructs showed high radiological density and compressive strength. • These characteristics were similar to those of native bone. -- Abstract: The development of bone tissue engineering has provided new solutions for bone defects. However, the cell-scaffold-based approaches currently in use have several limitations, including low cell seeding rates and poor bone formation capacity. In the present study, we developed a novel strategy to engineer bone grafts using mesenchymal stem cell sheets and coral particles. Rabbit bone marrow mesenchymal stem cells were continuously cultured to form a cell sheet with osteogenic potential and coral particles were integrated into the sheet. The composite sheet was then wrapped around a cylindrical mandrel to fabricate a tubular construct. The resultant tubular construct was cultured in a spinner-flask bioreactor and subsequently implanted into a subcutaneous pocket in a nude mouse for assessment of its histological characteristics, radiological density and mechanical property. A similar construct assembled from a cell sheet alone acted as a control. In vitro observations demonstrated that the composite construct maintained its tubular shape, and exhibited higher radiological density, compressive strength and greater extracellular matrix deposition than did the control construct. In vivo experiments further revealed that new bone formed ectopically on the composite constructs, so that the 8-week explants of the composite sheets displayed radiological density similar to that of native bone. These results indicate that the strategy of using a combination of a cell sheet and coral particles has great potential for bone tissue engineering and repairing bone defects.

Geng, Wenxin [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China)] [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China); Ma, Dongyang [Department of Oral and Maxillofacial Surgery, Lanzhou General Hospital, Lanzhou Command of PLA, BinHe 333 South Road, Lanzhou 730052 (China)] [Department of Oral and Maxillofacial Surgery, Lanzhou General Hospital, Lanzhou Command of PLA, BinHe 333 South Road, Lanzhou 730052 (China); Yan, Xingrong; Liu, Liangqi; Cui, Jihong; Xie, Xin; Li, Hongmin [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China)] [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China); Chen, Fulin, E-mail: chenfl@nwu.edu.cn [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China)] [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China)

2013-04-19T23:59:59.000Z

255

Bone status in high levels cyclists J Clin Densitom. 2012 Jan-Mar;15(1):103-7. Evaluation of the Bone Status in High-Level Cyclists  

E-Print Network [OSTI]

health Organization has defined osteoporosis in post-menopausal women as a T-score value less than -2) defines a "low bone density". In post-menopausal women as well as in elderly in general, results are more

Paris-Sud XI, Université de

256

Bone marrow transplantation after the Chernobyl nuclear accident  

SciTech Connect (OSTI)

On April 26, 1986, an accident at the Chernobyl nuclear power station in the Soviet Union exposed about 200 people to large doses of total-body radiation. Thirteen persons exposed to estimated total-body doses of 5.6 to 13.4 Gy received bone marrow transplants. Two transplant recipients, who received estimated doses of radiation of 5.6 and 8.7 Gy, are alive more than three years after the accident. The others died of various causes, including burns (the cause of death in five), interstitial pneumonitis (three), graft-versus-host disease (two), and acute renal failure and adult respiratory distress syndrome (one). There was hematopoietic (granulocytic) recovery in nine transplant recipients who could be evaluated, six of whom had transient partial engraftment before the recovery of their own marrow. Graft-versus-host disease was diagnosed clinically in four persons and suspected in two others. Although the recovery of endogenous hematopoiesis may occur after exposure to radiation doses of 5.6 to 13.4 Gy, we do not know whether it is more likely after the transient engraftment of transplanted stem cells. Because large doses of radiation affect multiple systems, bone marrow recovery does not necessarily ensure survival. Furthermore, the risk of graft-versus-host disease must be considered when the benefits of this treatment are being weighed.

Baranov, A.; Gale, R.P.; Guskova, A.; Piatkin, E.; Selidovkin, G.; Muravyova, L.; Champlin, R.E.; Danilova, N.; Yevseeva, L.; Petrosyan, L. (Institute of Biophysics of the Ministry of Health and Clinical Hospital, Moscow (USSR))

1989-07-27T23:59:59.000Z

257

Bone Surface Reconstruction From CT/MR Images Using Fast Marching and Level Set Methods1)  

E-Print Network [OSTI]

Bone Surface Reconstruction From CT/MR Images Using Fast Marching and Level Set Methods1) Istv surfaces reconstructed from MR volumes are shown. 1 Outline of the project One of our current projects steps of bone surface reconstruction from CT/MR slice images. 2 Main steps of reconstruction 2.1

Chetverikov, Dmitry

258

Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis  

E-Print Network [OSTI]

Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis Beata secondary osteoporosis. Risk factors for development of TZD-induced secondary osteoporosis are gender (women healing in T2DM patients on TZD therapy. Keywords Diabetes . Thiazolidinediones . Bone . Osteoporosis

Toledo, University of

259

A multi-scale bone study to estimate the risk of fracture related to osteoporosis  

E-Print Network [OSTI]

A multi-scale bone study to estimate the risk of fracture related to osteoporosis Abdelwahed' Orléans, 8, Rue Léonard de Vinci 45072 Orléans, France Objective: Osteoporosis is a disease marked. Bone fractures caused by the osteoporosis become increasingly important goal for both clinicians

Paris-Sud XI, Université de

260

Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing rats  

E-Print Network [OSTI]

Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing-Chomponelle, Theix, 63110 Beaumont, France. Summary. (1) Magnesium deficiency was induced in Sprague-Dawley male rats of deprivation. (3) The leg bones were fragmented as shown in figure 1. Their magnesium content had decreased

Paris-Sud XI, Université de

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival  

E-Print Network [OSTI]

for post-menopausal osteoporosis (Sambrook and Cooper, 2006). Estrogen and ERs are important for bone and Musculoskeletal Biology, Wyeth Research, Collegeville, PA, USA Estrogen deficiency in menopause is a major cause of osteoporosis in women. Estrogen acts to maintain the appropriate ratio between bone-forming osteoblasts

Brown, Myles

262

Research Paper A method for calibration of bone driver transducers to measure the mastoid  

E-Print Network [OSTI]

vibrator transducers for clinical measurements, the transfer of energy from the bone driver depends. This absolute calibration is based upon a circuit model of the driver, describing it with three frequency in the clinic, and a refined bone driver circuit model is proposed to better capture the observed behaviors. Ã?

Allen, Jont

263

The effect of alcohol on the bone growth spurt of rats at a time equivalent to adolescent females  

E-Print Network [OSTI]

. The trabecular bone that remained was widely separated and reduced in thickness. These changes are similar to those observed in osteoporosis. The cause and mechanism of the reduced bone volume after alcohol abuse remains unclear. Alcohol consumption at an early...

Chaffin, Catherine Lee

1997-01-01T23:59:59.000Z

264

Single x-ray transmission system for bone mineral density determination  

SciTech Connect (OSTI)

Bones are the support of the body. They are composed of many inorganic compounds and other organic materials that all together can be used to determine the mineral density of the bones. The bone mineral density is a measure index that is widely used as an indicator of the health of the bone. A typical manner to evaluate the quality of the bone is a densitometry study; a dual x-ray absorptiometry system based study that has been widely used to assess the mineral density of some animals' bones. However, despite the success stories of utilizing these systems in many different applications, it is a very expensive method that requires frequent calibration processes to work properly. Moreover, its usage in small species applications (e.g., rodents) has not been quite demonstrated yet. Following this argument, it is suggested that there is a need for an instrument that would perform such a task in a more reliable and economical manner. Therefore, in this paper we explore the possibility to develop a new, affordable, and reliable single x-ray absorptiometry system. The method consists of utilizing a single x-ray source, an x-ray image sensor, and a computer platform that all together, as a whole, will allow us to calculate the mineral density of the bone. Utilizing an x-ray transmission theory modified through a version of the Lambert-Beer law equation, a law that expresses the relationship among the energy absorbed, the thickness, and the absorption coefficient of the sample at the x-rays wavelength to calculate the mineral density of the bone can be advantageous. Having determined the parameter equation that defines the ratio of the pixels in radiographies and the bone mineral density [measured in mass per unit of area (g/cm{sup 2})], we demonstrated the utility of our novel methodology by calculating the mineral density of Wistar rats' femur bones.

Jimenez-Mendoza, Daniel; Vargas-Vazquez, Damian [Division de Investigacion y Posgrado, Facultad de Ingenieria, Universidad Autonoma de Queretaro, Cerro de las Campanas s/n., C.P. 76010, Queretaro, Qro. (Mexico); Espinosa-Arbelaez, Diego G. [Posgrado en Ciencia e Ingenieria en Materiales, Instituto de Investigaciones en Materiales, Universidad Nacional Autonoma de Mexico, Av. Universidad 3000, C.P. 04510, Coyoacan, Mexico D.F. (Mexico); Departamento de Nanotecnologia, Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Boulevard Juriquilla 3001, C.P. 76230, A.P. 1-1010, Juriquilla, Qro. (Mexico); Giraldo-Betancur, Astrid L. [Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Libramiento Norponiente 2000, C.P. 76230, Fracc. Real de Juriquilla, Qro. (Mexico); Hernandez-Urbiola, Margarita I. [Posgrado en Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Boulevard Juriquilla 3001, C.P. 76230, A.P. 1-1010, Juriquilla, Qro. (Mexico); Departamento de Nanotecnologia, Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Boulevard Juriquilla 3001, C.P. 76230, A.P. 1-1010, Juriquilla, Qro. (Mexico); Rodriguez-Garcia, Mario E. [Departamento de Nanotecnologia, Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Boulevard Juriquilla 3001, C.P. 76230, A.P. 1-1010, Juriquilla, Qro. (Mexico)

2011-12-15T23:59:59.000Z

265

Human-machine interactions  

SciTech Connect (OSTI)

Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

Forsythe, J. Chris (Sandia Park, NM); Xavier, Patrick G. (Albuquerque, NM); Abbott, Robert G. (Albuquerque, NM); Brannon, Nathan G. (Albuquerque, NM); Bernard, Michael L. (Tijeras, NM); Speed, Ann E. (Albuquerque, NM)

2009-04-28T23:59:59.000Z

266

EARLY PREVENTIVE EFFECTS OF RISEDRONATE IN A RAT MODEL WITH MASSIVE BONE LOSS DUE TO ORCHIDECTOMY AND  

E-Print Network [OSTI]

and disuse induced osteoporosis. ORX and BTX models were combined to see if their effects were cumulative on trabecular bone mass and bone architecture. KEY WORDS: Osteoporosis Orchidectomy Disuse Risedronate Bone-remodeling rate is observed in women after menopause or surgica

Paris-Sud XI, Université de

267

Increased copy number for methylated maternal 15q duplications leads to changes in gene and protein expression in human cortical samples  

E-Print Network [OSTI]

15q. Am J Med Genet 6. Battaglia A: The inv dup (15) orAm J Hum Genet 1997, 8. Battaglia A: The inv dup(15) or

Scoles, Haley A; Urraca, Nora; Chadwick, Samuel W; Reiter, Lawrence T; LaSalle, Janine M

2011-01-01T23:59:59.000Z

268

Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells  

SciTech Connect (OSTI)

Mesenchymal stem cells (MSC) from mouse bone marrow were shown to adopt a pancreatic endocrine phenotype in vitro and to reverse diabetes in an animal model. MSC from human bone marrow and adipose tissue represent very similar cell populations with comparable phenotypes. Adipose tissue is abundant and easily accessible and could thus also harbor cells with the potential to differentiate in insulin producing cells. We isolated human adipose tissue-derived MSC from four healthy donors. During the proliferation period, the cells expressed the stem cell markers nestin, ABCG2, SCF, Thy-1 as well as the pancreatic endocrine transcription factor Isl-1. The cells were induced to differentiate into a pancreatic endocrine phenotype by defined culture conditions within 3 days. Using quantitative PCR a down-regulation of ABCG2 and up-regulation of pancreatic developmental transcription factors Isl-1, Ipf-1, and Ngn3 were observed together with induction of the islet hormones insulin, glucagon, and somatostatin.

Timper, Katharina [Department of Research, University Hospital, Basel (Switzerland); Seboek, Dalma [Department of Research, University Hospital, Basel (Switzerland); Eberhardt, Michael [Department of Research, University Hospital, Basel (Switzerland); Linscheid, Philippe [Department of Research, University Hospital, Basel (Switzerland); Christ-Crain, Mirjam [Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland); Keller, Ulrich [Department of Research, University Hospital, Basel (Switzerland); Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland); Mueller, Beat [Department of Research, University Hospital, Basel (Switzerland); Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland); Zulewski, Henryk [Department of Research, University Hospital, Basel (Switzerland) and Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland)]. E-mail: henryk.zulewski@unibas.ch

2006-03-24T23:59:59.000Z

269

Cognitive Science (Humanities)  

E-Print Network [OSTI]

Cognitive Science (Humanities) The University of Edinburgh College of Humanities and Social Science: Cognitive Science (Humanities) BSc Honours in: Cognitive Science Please see separate information sheets the disciplines that contribute to the study of human cognition. The Cognitive Science programme at Edinburgh

Schnaufer, Achim

270

Inorganic-Organic Shape Memory Polymers and Foams for Bone Defect Repairs  

E-Print Network [OSTI]

increased its bioactivity, giving rise to the formation of “bone-bonding” hydroxyapatite (HAp) when exposed to simulated body fluid (SBF). It was also shown that the coating largely enhanced the scaffold’s capacities to support osteoblasts adhesion...

Zhang, Dawei

2013-04-16T23:59:59.000Z

271

Effects of High Dietary Iron and Gamma Radiation on Oxidative Stress and Bone  

E-Print Network [OSTI]

(induced by feeding a high iron diet) and gamma radiation exposure would independently increase markers of oxidative stress and markers of oxidative damage and result in loss of bone mass, with the combined treatment having additive or synergistic effects...

Yuen, Evelyn P

2013-04-19T23:59:59.000Z

272

Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells  

E-Print Network [OSTI]

Our objective was to test the hypothesis that self-assembling peptide hydrogel scaffolds provide cues that enhance the chondrogenic differentiation of bone marrow stromal cells (BMSCs). BMSCs were encapsulated within two ...

Kopesky, Paul Wayne

273

Immobilized sonic hedgehog N-terminal signaling domain enhances differentiation of bone marrow-derived  

E-Print Network [OSTI]

, and immobilized onto interpenetrating polymer network (IPN) surfaces also grafted with a bone sialoprotein presented to cells using an intrinsically nonfouling interpenetrating polymer network (IPN).12,13 In spite

Schaffer, David V.

274

E-Print Network 3.0 - arthritic bone loss Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Knee Arthroplasty in a Series of 48 Patients Summary: with the loss of thickness of polyethylene tibial bearings after knee arthroplasty. J Bone Joint Surg Am. 2007... -4 Optimal...

275

Pretreatment levels of bone turnover and the antifracture efficacy of alendronate: The fracture intervention trial  

E-Print Network [OSTI]

in postmenopausal osteoporosis. Cal- cif Tissue Int 65:359–in postmeno- pausal osteoporosis. J Bone Miner Res 12:624–among women without osteoporosis at baseline. Although they

2006-01-01T23:59:59.000Z

276

Race/ethnic differences in bone mineral densities in older men  

E-Print Network [OSTI]

the Baltimore men’s osteoporosis study. J Bone Miner Res 13.center genetic study of osteoporosis. Osteoporos Int 17:125–Leung Jockey Club Centre for Osteoporosis Care and Control,

2010-01-01T23:59:59.000Z

277

E-Print Network 3.0 - adult bone marrow-derived Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

32:69-77. 5. Garman R, Gaudette G, Donahue L, et al. 2007. Low... from bone marrow of young adult rats. Cell Tissue ... Source: You, Lidan - Department of Mechanical and...

278

Discovery of novel anti-inflammatory proteins inspired by bone marrow mesenchymal stem cell secretions  

E-Print Network [OSTI]

Bone marrow mesenchymal stem cells (MSCs) may soon become the first FDA-approved stem cell therapy for autoimmune and inflammatory disease. Our lab originally hypothesized that much of the therapeutic activity of MSCs may ...

Milwid, Jack Miles

2011-01-01T23:59:59.000Z

279

Investigation of bone response to implant materials by electron microscopy and computer simulation  

E-Print Network [OSTI]

(cont.) implementation of this scintigraphic method for quantitative studies of osteoblast-mediated mineralization in vitro. A 2-D truss finite element model is used to study the remodeling of trabecular bone. Using strain ...

Wang, Hao, 1974-

2004-01-01T23:59:59.000Z

280

Non-invasive shock wave stimulated periosteum for bone tissue engineering  

E-Print Network [OSTI]

The cambium cells of the periosteum, which are known osteoprogenitor cells, have limited suitability for clinical applications of bone tissue engineering due to their low cell number (2-5 cells thick). Extracorporeal shock ...

Kearney, Cathal (Cathal John)

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Growth and bone development in weanling quarter horses fed diets supplemented with sodium zeolite-A  

E-Print Network [OSTI]

GROWTH AND BONE DEVELOPMENT IN WEANLING QUARTER HORSES FED DIETS SUPPLEMENTED WITH SODIUM ZEOLITE-A A Thesis by KIMBERLY SUZANNE FREY Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE December 1991 Major Subject: Nutrition GROWTH AND BONE DEVELOPMENT IN WEANLING QUARTER HORSES FED DIETS SUPPLER WITH SODIUM ZEOLITE-A A Thesis by KIMBERLY SUZPZPK FREY Approved as to style and content by...

Frey, Kimberly Suzanne

1991-01-01T23:59:59.000Z

282

Analysis of a Fossil Bone from the Archaeological Settlement Malu Rosu, Romania by Accelerator Mass Spectrometry  

E-Print Network [OSTI]

A fossil bone from the archaeological site Malu Rosu Giurgiu, in Romania has been analyzed by accelerator mass spectrometry to estimate its age by determining its $^{14}$C content. The radiocarbon age of the bone is in agreement with the date obtained by the method for age determination, based on fluorine content. This is the first radiocarbon dating for the final Neolithic period, for this archaeological settlement in the Romanian region.

Agata Olariu; Ion V. Popescu; Ragnar Hellborg; Kristina Stenström; Mikko Faarinen; Per Persson; Bengt Erlandsson; Göran Skog; Emilian Alexandrescu

2001-03-13T23:59:59.000Z

283

The Effects of Multiple Unloading Exposures on Bone Properties in the Femur of Adult Male Rats  

E-Print Network [OSTI]

to the National Osteoporosis Foundation, approximately 10 million people have the condition, with another 34 million currently at risk. It is estimated that half of all women over 50 and a quarter of all men will break a bone due to osteoporosis (10). Fractures....? During long term missions, such as to Mars, the astronauts may encounter situations where they could experience high impact forces relative to those experienced in transit. This, coupled with a potential reduction in bone strength due to microgravity...

Morgan, Derrick Scott

2012-07-16T23:59:59.000Z

284

The distribution of electrical potential in long bone under mechanical stress  

E-Print Network [OSTI]

Nember N I December 19'75 ~a39326 ABSTRACT The Distribution of Electrical Potential in Long Bone Under Mechanical Stress. (December 1975) Chao-Jan Cheng, B. S. , Texas AkM University Chairman of Advi. sory Committee & Dr. Richard J, Jendrucko.... It was not until the early 1960's that Bassett, et al. (1964) presented the first convincing evidence for electr1cally induced bone formation, Subsequently, Minkin, et al. (1968) passed electrical currents through rabbit femur and observed varying degrees...

Cheng, Chao-Jan

2012-06-07T23:59:59.000Z

285

Human Resources Assistant  

Broader source: Energy.gov [DOE]

This position is located in the Headquarters (HQ) Operations Division of the Office of the Chief Human Capital Officer in Washington, DC. The Division provides a full range of human capital...

286

Human Functional Brain Imaging  

E-Print Network [OSTI]

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review #12;2 | Portfolio Review: Human Functional Brain ImagingThe Wellcome Trust is a charity registered in England and Wales, no's role in supporting human functional brain imaging and have informed `our' speculations for the future

Rambaut, Andrew

287

Human Research ProgramHuman Research Program Human System Risk in Exploration and  

E-Print Network [OSTI]

Human System Risks in Exploration Missions 21SEP10 2HRP Risk Process ­ D.Grounds Presentation contentsHuman Research ProgramHuman Research Program Human System Risk in Exploration and the Human Research Program 21SEP10 1HRP Risk Process ­ D Grounds #12;Human Research ProgramHuman Research Program

Waliser, Duane E.

288

Effect of 710 nm visible light irradiation on neurite outgrowth in primary rat cortical neurons following ischemic insult  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer 710 nm wavelength light (LED) has a protective effect in the stroke animal model. Black-Right-Pointing-Pointer We determined the effects of LED irradiation in vitro stroke model. Black-Right-Pointing-Pointer LED treatment promotes the neurite outgrowth through MAPK activation. Black-Right-Pointing-Pointer The level of synaptic markers significantly increased with LED treatment. Black-Right-Pointing-Pointer LED treatment protects cell death in the in vitro stroke model. -- Abstract: Objective: We previously reported that 710 nm Light-emitting Diode (LED) has a protective effect through cellular immunity activation in the stroke animal model. However, whether LED directly protects neurons suffering from neurodegeneration was entirely unknown. Therefore, we sought to determine the effects of 710 nm visible light irradiation on neuronal protection and neuronal outgrowth in an in vitro stroke model. Materials and methods: Primary cultured rat cortical neurons were exposed to oxygen-glucose deprivation (OGD) and reoxygenation and normal conditions. An LED array with a peak wavelength of 710 nm was placed beneath the covered culture dishes with the room light turned off and were irradiated accordingly. LED treatments (4 min at 4 J/cm{sup 2} and 50 mW/cm{sup 2}) were given once to four times within 8 h at 2 h intervals for 7 days. Mean neurite density, mean neurite diameter, and total fiber length were also measured after microtubule associated protein 2 (MAP2) immunostaining using the Axio Vision program. Synaptic marker expression and MAPK activation were confirmed by Western blotting. Results: Images captured after MAP2 immunocytochemistry showed significant (p < 0.05) enhancement of post-ischemic neurite outgrowth with LED treatment once and twice a day. MAPK activation was enhanced by LED treatment in both OGD-exposed and normal cells. The levels of synaptic markers such as PSD 95, GAP 43, and synaptophysin significantly increased with LED treatment in both OGD-exposed and normal cells (p < 0.05). Conclusion: Our data suggest that LED treatment may promote synaptogenesis through MAPK activation and subsequently protect cell death in the in vitro stroke model.

Choi, Dong-Hee [Center for Neuroscience Research, SMART Institute of Advanced Biomedical Science, Konkuk University, Seoul (Korea, Republic of) [Center for Neuroscience Research, SMART Institute of Advanced Biomedical Science, Konkuk University, Seoul (Korea, Republic of); Department of Medical Science, Konkuk University School of Medicine, Seoul (Korea, Republic of); Lee, Kyoung-Hee; Kim, Ji-Hye; Kim, Moon Young [Center for Neuroscience Research, SMART Institute of Advanced Biomedical Science, Konkuk University, Seoul (Korea, Republic of)] [Center for Neuroscience Research, SMART Institute of Advanced Biomedical Science, Konkuk University, Seoul (Korea, Republic of); Lim, Jeong Hoon [Department of Rehabilitation Medicine, Konkuk University School of Medicine, Seoul (Korea, Republic of) [Department of Rehabilitation Medicine, Konkuk University School of Medicine, Seoul (Korea, Republic of); Rehabilitation Medicine, Division of Neurology, Department of Medicine, National University Hospital, National University Health System (Singapore); Lee, Jongmin, E-mail: leej@kuh.ac.kr [Center for Neuroscience Research, SMART Institute of Advanced Biomedical Science, Konkuk University, Seoul (Korea, Republic of) [Center for Neuroscience Research, SMART Institute of Advanced Biomedical Science, Konkuk University, Seoul (Korea, Republic of); Department of Rehabilitation Medicine, Konkuk University School of Medicine, Seoul (Korea, Republic of)

2012-06-01T23:59:59.000Z

289

"Bone Softening," a Practical Way to Utilize Small Fish  

E-Print Network [OSTI]

. Even in Japan, where per-capita fish consumption is about 5 times that of the United States, small tons in 1986) is used primarily for fish meal rather than for direct human consumption. Looking for ways to increase direct consumption of sar dines and other small fishes, Japanese researchers

290

Effect of dietary calcium and phosphorus levels on performance and bone development of large-framed developing boars  

E-Print Network [OSTI]

quantitative carcass measurement among boars fed the six treatment diets. Bone breaking load (BKL) of the femurs increased quadratically (P&. 01) as mineral levels increased with a predicted maximum response at 1. 21X calcium and 1. 01X phosphorus. Breaking..., feed intake and feed efficiency for developing boars. However, higher dietary phosphorus levels were needed for maximum bone develop- ment. Maximum response was obtained from the following phosphorus levels: bone breaking load ranged from 1. 01X...

Robinson, Robert Glen

1975-01-01T23:59:59.000Z

291

Electron Microscopy and Analytical X-ray Characterization of Compositional and Nanoscale Structural Changes in Fossil Bone  

E-Print Network [OSTI]

on the identification of surviving collagen in bulk bonebulk regions of bone. This fact might prove exceptionally true if the identification

Boatman, Elizabeth

2012-01-01T23:59:59.000Z

292

Automated simulation of areal bone mineral density assessment in the distal radius from high-resolution peripheral quantitative computed tomography  

E-Print Network [OSTI]

Bone mineral density . DXA . HR-pQCT . Osteoporosis .Simulation Introduction Osteoporosis is a conditionclinical assessment of osteoporosis status were identified

Burghardt, A. J.; Kazakia, G. J.; Link, T. M.; Majumdar, S.

2009-01-01T23:59:59.000Z

293

Automated 3D trabecular bone structure analysis of the proximal femur—prediction of biomechanical strength by CT and DXA  

E-Print Network [OSTI]

z ORIGINAL ARTICLE Automated 3D trabecular bone structureIntroduction An automated 3D segmentation algorithm wasstudy was to use an automated 3D segmentation algorithm to

2010-01-01T23:59:59.000Z

294

Evaluation of dual energy quantitative CT for determining the spatial distributions of red marrow and bone for dosimetry in internal emitter radiation therapy  

SciTech Connect (OSTI)

Purpose: To evaluate a three-equation three-unknown dual-energy quantitative CT (DEQCT) technique for determining region specific variations in bone spongiosa composition for improved red marrow dose estimation in radionuclide therapy. Methods: The DEQCT method was applied to 80/140 kVp images of patient-simulating lumbar sectional body phantoms of three sizes (small, medium, and large). External calibration rods of bone, red marrow, and fat-simulating materials were placed beneath the body phantoms. Similar internal calibration inserts were placed at vertebral locations within the body phantoms. Six test inserts of known volume fractions of bone, fat, and red marrow were also scanned. External-to-internal calibration correction factors were derived. The effects of body phantom size, radiation dose, spongiosa region segmentation granularity [single (?17 × 17 mm) region of interest (ROI), 2 × 2, and 3 × 3 segmentation of that single ROI], and calibration method on the accuracy of the calculated volume fractions of red marrow (cellularity) and trabecular bone were evaluated. Results: For standard low dose DEQCT x-ray technique factors and the internal calibration method, the RMS errors of the estimated volume fractions of red marrow of the test inserts were 1.2–1.3 times greater in the medium body than in the small body phantom and 1.3–1.5 times greater in the large body than in the small body phantom. RMS errors of the calculated volume fractions of red marrow within 2 × 2 segmented subregions of the ROIs were 1.6–1.9 times greater than for no segmentation, and RMS errors for 3 × 3 segmented subregions were 2.3–2.7 times greater than those for no segmentation. Increasing the dose by a factor of 2 reduced the RMS errors of all constituent volume fractions by an average factor of 1.40 ± 0.29 for all segmentation schemes and body phantom sizes; increasing the dose by a factor of 4 reduced those RMS errors by an average factor of 1.71 ± 0.25. Results for external calibrations exhibited much larger RMS errors than size matched internal calibration. Use of an average body size external-to-internal calibration correction factor reduced the errors to closer to those for internal calibration. RMS errors of less than 30% or about 0.01 for the bone and 0.1 for the red marrow volume fractions would likely be satisfactory for human studies. Such accuracies were achieved for 3 × 3 segmentation of 5 mm slice images for: (a) internal calibration with 4 times dose for all size body phantoms, (b) internal calibration with 2 times dose for the small and medium size body phantoms, and (c) corrected external calibration with 4 times dose and all size body phantoms. Conclusions: Phantom studies are promising and demonstrate the potential to use dual energy quantitative CT to estimate the spatial distributions of red marrow and bone within the vertebral spongiosa.

Goodsitt, Mitchell M., E-mail: goodsitt@umich.edu; Shenoy, Apeksha; Howard, David; Christodoulou, Emmanuel; Dewaraja, Yuni K. [Department of Radiology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States)] [Department of Radiology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States); Shen, Jincheng [Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, Michigan 48109 (United States)] [Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, Michigan 48109 (United States); Schipper, Matthew J. [Department of Radiation Oncology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States)] [Department of Radiation Oncology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States); Wilderman, Scott [Department of Nuclear Engineering, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States)] [Department of Nuclear Engineering, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States); Chun, Se Young [Ulsan National Institute of Science and Technology (UNIST), School of Electrical and Computer Engineering, Ulsan 689-798 (Korea, Republic of)] [Ulsan National Institute of Science and Technology (UNIST), School of Electrical and Computer Engineering, Ulsan 689-798 (Korea, Republic of)

2014-05-15T23:59:59.000Z

295

Clinical Assessment of Percutaneous Radiofrequency Ablation for Painful Metastatic Bone Tumors  

SciTech Connect (OSTI)

Purpose. To investigate the pain-alleviating effects of radiofrequency ablation (RFA) on metastatic bone tumors in relation to tumor size, combined therapy, and percent tumor necrosis rate following RFA. Methods. Subjects comprised 24 patients with 28 painful metastatic bone tumors. A 17G internally cooled electrode was inserted into the tumor for CT guidance and ablation was performed. Bone cement was injected following RFA for 4 tumors involving a weight-bearing bone, while 5 tumors were treated using combined RFA and external irradiation. Percent necrosis rate of the tumor was measured using contrast-enhanced computed tomography 1 week after RFA. Results. Improvement in the visual analog scale (VAS) score was 4.6 {+-} 2.2 for large tumors (>5 cm, n = 12), 3.7 {+-} 1.8 for medium-sized tumors (3.1-5.0 cm, n = 11), and 3.5 {+-} 1.7 for small tumors ({<=}3 cm, n = 4), with no significant differences noted among tumor sizes. Improvement in the VAS score was 3.5 {+-} 1.3 for the 4 tumors in the RFA + bone cement group, 3.2 {+-} 1.9 for the 5 tumors in the RFA + radiation therapy group, and 4.8 {+-} 2.2 for the 18 tumors in the RFA group. No significant differences were identified between groups. The improvement in the VAS score was 3.8 {+-} 2.3, 4.0 {+-} 1.9, and 4.7 {+-} 2.6 in patients with tumor necrosis rates of 0-49%, 50-74%, and 75-100%, respectively. No significant association was observed among these three groups. Conclusion. Percutaneous RFA therapy was effective in relieving pain due to metastatic bone tumors. No relationships appear to exist between initial response and tumor size, combined therapy, and percent tumor necrosis.

Kojima, Hiroyuki, E-mail: kojimah@takii.kmu.ac.jp; Tanigawa, Noboru; Kariya, Shuji; Komemushi, Atsushi; Shomura, Yuzo; Sawada, Satoshi [Kansai Medical University Takii Hospital, Department of Radiology (Japan)

2006-12-15T23:59:59.000Z

296

Feeding Bone Meal to Range Cattle on the Coastal Plains of Texas : Preliminary Report.  

E-Print Network [OSTI]

Troup, Smith County: M. S~.E~~~~~, M. S., ~nimil Husband- fV. k. HOTCHKISS, Superintendent man Charge of Farm No 3 Angleton Brazoria County: L, J. McCALL. Farm Superintendent I?. 1-IAFNER: B. S., Superintendent No 11 Nacogdoches Nacogdoches County... and salt mixtures and finely ground rock phosphate mixed with bone meal and salt to cattle in the Gulf Coast region of Texas. It was found that the bone-chewing habit exhibited by about seventy-five per cent of the range cattle in that region can...

Schmidt, H.

1926-01-01T23:59:59.000Z

297

Mechanical interaction between cells and fluid for bone tissue engineering scaffold: Modulation of the interfacial shear stress  

E-Print Network [OSTI]

Mechanical interaction between cells and fluid for bone tissue engineering scaffold: Modulation Analytical solution Bone tissue engineering a b s t r a c t An analytical model of the fluid/cell mechanical n f o Article history: Accepted 1 November 2009 Keywords: Cell fluid interaction Shear stress

Guerraoui, Rachid

298

Development of a three-dimensional in vitro model to study the effect of vitamin D on bone metastatic breast cancer  

E-Print Network [OSTI]

Breast cancer has a high prevalence among women and most patients suffer from metastasis to bone. The mechanisms involved in breast cancer bone metastasis are poorly understood. Three-dimensional (3D) tissue culture systems are becoming a focus...

Li, Danda

2011-08-31T23:59:59.000Z

299

Cancellous Bone Properties and Matrix Content of TGF-?2 and IGF-I in Human Tibia: A Pilot Study  

E-Print Network [OSTI]

in osteoblasts results in an osteoporosis-like phenotype. Jconsiderable, permanent osteoporosis in the affected knee. Jgeneric susceptibility to osteoporosis in postmenopausal

Yeni, Yener N.; Dong, X. Neil; Zhang, Bingbing; Gibson, Gary J.; Fyhrie, David P.

2009-01-01T23:59:59.000Z

300

DESIGN OF FOAM COVERING FOR ROBOTIC ARMS TO ENSURE HUMAN SAFETY Lingqi Zeng and Gary M. Bone  

E-Print Network [OSTI]

and experimental peak impact force results is 8%. 1. INTRODUCTION Whether in industrial applications such as teach programming, or service applications such as rescue robots, robotic manipulators are operating closer and maintain, which limits their applicability. Using foam to cover the robot arm surface is a simple

Bone, Gary

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

To establish DOE procedures and responsibilities for implementing the policy and requirements set forth in 10 CFR Part 745, Protection of Human Subjects, ad in DOE P 443.1, Policy on the Protection of Human Subjects. Cancels DOE O 1300.3. Canceled by DOE O 443.1A.

2000-05-15T23:59:59.000Z

302

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects; and in DOE P 443.1A, Protection of Human Subjects, dated 12-20-07. Cancels DOE O 443.1. Canceled by DOE O 443.1B.

2007-12-20T23:59:59.000Z

303

STUDENT EMPLOYMENT HUMAN RESOURCES  

E-Print Network [OSTI]

STUDENT EMPLOYMENT HUMAN RESOURCES GUIDELINE Human Resources | One Washington Square | San José, CA 95192-0046 | 408-924-2250 408-924-2284 (fax) SUBJECT: STUDENT EMPLOYMENT DATE: March 2007 I. PURPOSE / DESCRIPTION Student employees are defined as matriculated students that work part-time in any

Gleixner, Stacy

304

Human Functional Brain Imaging  

E-Print Network [OSTI]

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review Summary Brain Imaging #12 Dale ­ one of our first Trustees. Understanding the brain remains one of our key strategic aims today three-fold: · to identify the key landmarks and influences on the human functional brain imaging

Rambaut, Andrew

305

Beliefs about Human Extinction  

SciTech Connect (OSTI)

This paper presents the results of a web-based survey about futures issues. Among many questions, respondents were asked whether they believe humans will become extinct. Forty-five percent of the almost 600 respondents believe that humans will become extinct. Many of those holding this believe felt that humans could become extinct within 500-1000 years. Others estimated extinction 5000 or more years into the future. A logistic regression model was estimated to explore the bases for this belief. It was found that people who describe themselves a secular are more likely to hold this belief than people who describe themselves as being Protestant. Older respondents and those who believe that humans have little control over their future also hold this belief. In addition, people who are more apt to think about the future and are better able to imagine potential futures tend to also believe that humans will become extinct.

Tonn, Bruce Edward [ORNL

2009-11-01T23:59:59.000Z

306

Dynamic T{sub 2}-mapping during magnetic resonance guided high intensity focused ultrasound ablation of bone marrow  

SciTech Connect (OSTI)

Focal bone tumor treatments include amputation, limb-sparing surgical excision with bone reconstruction, and high-dose external-beam radiation therapy. Magnetic resonance guided high intensity focused ultrasound (MR-HIFU) is an effective non-invasive thermotherapy for palliative management of bone metastases pain. MR thermometry (MRT) measures the proton resonance frequency shift (PRFS) of water molecules and produces accurate (<1 Degree-Sign C) and dynamic (<5s) thermal maps in soft tissues. PRFS-MRT is ineffective in fatty tissues such as yellow bone marrow and, since accurate temperature measurements are required in the bone to ensure adequate thermal dose, MR-HIFU is not indicated for primary bone tumor treatments. Magnetic relaxation times are sensitive to lipid temperature and we hypothesize that bone marrow temperature can be determined accurately by measuring changes in T{sub 2}, since T{sub 2} increases linearly in fat during heating. T{sub 2}-mapping using dual echo times during a dynamic turbo spin-echo pulse sequence enabled rapid measurement of T{sub 2}. Calibration of T{sub 2}-based thermal maps involved heating the marrow in a bovine femur and simultaneously measuring T{sub 2} and temperature with a thermocouple. A positive T{sub 2} temperature dependence in bone marrow of 20 ms/ Degree-Sign C was observed. Dynamic T{sub 2}-mapping should enable accurate temperature monitoring during MR-HIFU treatment of bone marrow and shows promise for improving the safety and reducing the invasiveness of pediatric bone tumor treatments.

Waspe, Adam C.; Looi, Thomas; Mougenot, Charles; Amaral, Joao; Temple, Michael; Sivaloganathan, Siv; Drake, James M. [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, ON, M5G 1X8 (Canada); Philips Healthcare Canada, Markham, ON, L6C 2S3 (Canada); Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, ON, M5G 1X8 (Canada); Department of Applied Mathematics, University of Waterloo, Waterloo, ON, N2L 3G1 (Canada); Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, ON, M5G 1X8 (Canada)

2012-11-28T23:59:59.000Z

307

IBMS BoneKEy. 2009 April;6(4):132-149 http://www.bonekey-ibms.org/cgi/content/full/ibmske;6/4/132  

E-Print Network [OSTI]

and osteoporosis, yet uniquely ­ without targeting the resident fat or bone cell. IBMS BoneKEy. 2009 April;6(4):132-149. ©2009 International Bone & Mineral Society Introduction Osteoporosis and obesity, two of the most billion dollars in annual health service costs. (1) Osteoporosis, a disease characterized by diminished

308

Microfluidic purification and analysis of hematopoietic stem cells from bone Romana Schirhagl,a  

E-Print Network [OSTI]

Microfluidic purification and analysis of hematopoietic stem cells from bone marrow Romana to separate them from a whole-marrow sample. A microfluidic device was fabricated using an integrated membrane are restricted by the limited availability of stem cell sources.2,3 We believe that microfluidics can be used

Zare, Richard N.

309

USE OF CdTe DETECTORS IN BONE MINERAL MEASUREMENTS J. VOGEL, J. ULLMAN  

E-Print Network [OSTI]

375 USE OF CdTe DETECTORS IN BONE MINERAL MEASUREMENTS J. VOGEL, J. ULLMAN Nuclear Medicine. Cet ensemble emploie des détecteurs CdTe mesurant la transmission d'un faisceau collimaté de rayons X periods of prolonged bedrest or weightlessness. The unit employs CdTe detectors to mea- sure

Paris-Sud XI, Université de

310

1174 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 53, NO. 6, JUNE 2006 Microwave Drilling of Bones  

E-Print Network [OSTI]

1174 IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 53, NO. 6, JUNE 2006 Microwave Drilling*, Member, IEEE Abstract--This paper presents a feasibility study of drilling in fresh wet bone tissue in vitro using the microwave drill method [Jerby et al., 2002], toward testing its applicability

Gefen, Amit

311

From a Dry Bone to a Genetic Portrait: A Case Study of Sickle Cell Anemia  

E-Print Network [OSTI]

From a Dry Bone to a Genetic Portrait: A Case Study of Sickle Cell Anemia MARINA FAERMAN,1* ALMUT identification; Y chromosome polymorphic markers; sickle cell anemia ABSTRACT The potential and reliability sample, which represented a documented case of sickle cell anemia. -globin gene sequences obtained from

312

BONE DENSITOMETRY IN PEDIATRIC POPULATIONS: DISCREPANCIES IN THE DIAGNOSIS OF OSTEOPOROSIS BY DXA AND CT  

E-Print Network [OSTI]

BONE DENSITOMETRY IN PEDIATRIC POPULATIONS: DISCREPANCIES IN THE DIAGNOSIS OF OSTEOPOROSIS BY DXA, osteoporosis is frequently overdiagnosed in children when using dual-energy x-ray absorptiometry (DXA osteoporosis in pediatric populations. (J Pediatr 2005;146:776-9) D ual-energy x-ray absorptiometry (DXA

Valero-Cuevas, Francisco

313

School of Architecture, Design and the Built Environment Project Title: Artificial bone for prosthetic hip joints  

E-Print Network [OSTI]

formation by the Additive Manufacturing (AM) direct printing process. The artificial bone must and the development of new additive manufacturing techniques for medical devices. The group has active links and structural gradients into the prosthesis. It is envisioned this could involve the use of additively

Evans, Paul

314

Mechanical regulation of signaling pathways in bone, William R. Thompson a,  

E-Print Network [OSTI]

Review Mechanical regulation of signaling pathways in bone, William R. Thompson a, , Clinton T A wide range of cell types depend on mechanically induced signals to enable appropriate physiological re- sponses. The skeleton is particularly dependent on mechanical information to guide the resident cell

315

Estimated number of women likely to benefit from bone mineral density measurement in France  

E-Print Network [OSTI]

; Menopause Introduction The prevalence of osteoporosis is rising, most notably in postmenopausal women years of age with risk factors for osteoporosis likely to lead to bone mineral density measurement, an investigation reimbursed by the French national health insurance system in patients at risk for osteoporosis

Paris-Sud XI, Université de

316

A method for calibration of bone driver transducers to measure the mastoid Reggie Weece a  

E-Print Network [OSTI]

2010 Available online xxxx a b s t r a c t When using bone vibrator transducers for clinical a circuit model of the driver, describing it with three frequency-dependent parameters. Once these three circuit model is proposed to better capture the observed behaviors. Ã? 2010 Published by Elsevier B.V. 1

Allen, Jont

317

Stability and Three-Dimensional Analysis of Bone Formation in Longitudinally Fluted Miniscrew Implants  

E-Print Network [OSTI]

The purpose of the present study is to evaluate the effects of longitudinal flutes on mini-screw implant (MSI) bone healing and stability. Using 11 skeletally mature New Zealand White rabbits, 33 longitudinally fluted and 33 non-fluted MSIs were...

Truong, An Van

2014-04-22T23:59:59.000Z

318

UNIVERSITY OF CALIFORNIA, SANTA CRUZ Humanities Academic Human Resources  

E-Print Network [OSTI]

UNIVERSITY OF CALIFORNIA, SANTA CRUZ Humanities Academic Human Resources VOLUNTARY WORKLOAD/or Spring ____ Quarter(s) Funding Source: ________________________________________ (Salary adjustments

California at Santa Cruz, University of

319

Human Pathogen Importation Importing "Human" Pathogens from Outside Canada  

E-Print Network [OSTI]

Human Pathogen Importation Importing "Human" Pathogens from Outside Canada 1) Permits be obtained from the Public Health Agency Canada (PHAC) to facilitate customs clearance. 2) If a permit

320

Division of Human Resources Human Resources / Attendance and Leave Philosophy  

E-Print Network [OSTI]

Division of Human Resources PHILOSOPHY Human Resources / Attendance and Leave Philosophy Form Leave Act (FMLA). USF augments these provisions with local processes and philosophies and, in some cases

Meyers, Steven D.

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Associate Vice President Human Resources  

E-Print Network [OSTI]

Associate Vice President Human Resources Enjoy Athens! Great schools Affordable housing Eclectic Vice President for Human Resources. This position reports directly to the Vice President for Finance and Administration and provides leadership for the University's human resources programs and services

Arnold, Jonathan

322

Human Resources Simon Fraser University  

E-Print Network [OSTI]

Human Resources Simon Fraser University Administrative and Professional Staff Job Description A. Identification Position Number: 31482 Position Title: Administrative Assistant (Human Resources Liaison) Name guidance, direction, coordination and effective management and implementation of SFU's Human Resources

Kavanagh, Karen L.

323

Special Issue on Human Computing  

E-Print Network [OSTI]

The seven articles in this special issue focus on human computing. Most focus on two challenging issues in human computing, namely, machine analysis of human behavior in group interactions and context-sensitive modeling.

Nijholt, Anton

324

The human genome project  

SciTech Connect (OSTI)

The Human Genome Project will obtain high-resolution genetic and physical maps of each human chromosome and, somewhat later, of the complete nucleotide sequence of the deoxyribonucleic acid (DNA) in a human cell. The talk will begin with an extended introduction to explain the Project to nonbiologists and to show that map construction and sequence determination require extensive computation in order to determine the correct order of the mapped entities and to provide estimates of uncertainty. Computational analysis of the sequence data will become an increasingly important part of the project, and some computational challenges are described. 5 refs.

Bell, G.I.

1991-06-01T23:59:59.000Z

325

Parahippocampal and retrosplenial contributions to human spatial  

E-Print Network [OSTI]

navigational tasks and also during passive viewing of navigationally relevant stimuli such as environmental parahippocampal and retro- splenial cortices [4­10], regions that also respond strongly during passive viewing' or `house' area [13,14,22], its response to buildings is smaller than the response to scenes [11

Epstein, Russell A.

326

Lung cancer-derived Dickkopf1 is associated with bone metastasis and the mechanism involves the inhibition of osteoblast differentiation  

SciTech Connect (OSTI)

Highlights: •DKK1 level was associated with NSCLC bone metastases. •Lung tumor cells derived DKK1 inhibited osteoblast differentiation. •Lung tumor cells derived DKK1 modulates ?-catenin and RUNX2. -- Abstract: Wnt/?-catenin signaling and Dickkopf1 (DKK1) play important roles in the progression of lung cancer, which preferably metastasizes to skeleton. But the role of them in bone dissemination is poorly understood. This study aims to define the role of DKK1 in lung cancer bone metastases and investigate the underlying mechanism. Our results demonstrated that DKK1 over-expression was a frequent event in non-small-cell lung cancer (NSCLC) blood samples, and serous DKK1 level was much higher in bone metastatic NSCLC compared to non-bone metastatic NSCLC. We also found that conditioned medium from DKK1 over-expressing lung cancer cells inhibited the differentiation of osteoblast, determined by alkaline phosphatase activity and osteocalcin secretion, whereas the conditioned medium from DKK1 silencing lung cancer cells exhibited the opposite effects. Mechanistically, DKK1 reduced the level of ?-catenin and RUNX2, as well as inhibiting the nuclear translocation of ?-catenin. Taken together, these results suggested that lung cancer-produced DKK1 may be an important mechanistic link between NSCLC and bone metastases, and targeting DKK1 may be an effective method to treat bone metastase of NSCLC.

Chu, Tianqing; Teng, Jiajun; Jiang, Liyan; Zhong, Hua; Han, Baohui, E-mail: baohuihan1@163.com

2014-01-17T23:59:59.000Z

327

Human Reliability | ornl.gov  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Human Reliability SHARE Human Reliability The Structured Trusted Employee Program (STEP) Evaluation is an example of a method for identifying, assessing, and retaining reliable and...

328

Human Reliability Program Overview  

SciTech Connect (OSTI)

This presentation covers the high points of the Human Reliability Program, including certification/decertification, critical positions, due process, organizational structure, program components, personnel security, an overview of the US DOE reliability program, retirees and academia, and security program integration.

Bodin, Michael

2012-09-25T23:59:59.000Z

329

KRFTWRK – Global Human Electricity  

E-Print Network [OSTI]

Power Network 2.1.1 Virtual Power Plants The Global Powernetwork, based on "Virtual Power Plants", called "VPP". A "participant runs a virtual human power plant. Per every "

Prohaska, Rainer

2009-01-01T23:59:59.000Z

330

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The Policy is to establish DOE-specific principles for the protection of human subjects involved in DOE research. Cancels DOE P 443.1. Canceled by DOE O 443.1B

2007-12-20T23:59:59.000Z

331

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The purpose of this Policy is to establish DOE-specific policy for the protection of human subjects involved in DOE research. Canceled by DOE P 443.1A.

2000-05-15T23:59:59.000Z

332

Human Resource Management Delegation  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The notice is to clarifies and updates existing Human Resource Management Delegation Authorities and the levels to which they are delegated. Expired 6-28-97. Does not cancel any directives.

1996-06-28T23:59:59.000Z

333

TEMPORARY SUPPORT HUMAN RESOURCES  

E-Print Network [OSTI]

TEMPORARY SUPPORT HUMAN RESOURCES GUIDELINE Workforce Planning | One Washington Square | San José of the Request for Temporary Support, Workforce Planning will make a determination of the type of temporary

Su, Xiao

334

Developing Human Performance Measures  

SciTech Connect (OSTI)

Through the reactor oversight process (ROP), the U.S. Nuclear Regulatory Commission (NRC) monitors the performance of utilities licensed to operate nuclear power plants. The process is designed to assure public health and safety by providing reasonable assurance that licensees are meeting the cornerstones of safety and designated crosscutting elements. The reactor inspection program, together with performance indicators (PIs), and enforcement activities form the basis for the NRC’s risk-informed, performance based regulatory framework. While human performance is a key component in the safe operation of nuclear power plants and is a designated cross-cutting element of the ROP, there is currently no direct inspection or performance indicator for assessing human performance. Rather, when human performance is identified as a substantive cross cutting element in any 1 of 3 categories (resources, organizational or personnel), it is then evaluated for common themes to determine if follow-up actions are warranted. However, variability in human performance occurs from day to day, across activities that vary in complexity, and workgroups, contributing to the uncertainty in the outcomes of performance. While some variability in human performance may be random, much of the variability may be attributed to factors that are not currently assessed. There is a need to identify and assess aspects of human performance that relate to plant safety and to develop measures that can be used to successfully assure licensee performance and indicate when additional investigation may be required. This paper presents research that establishes a technical basis for developing human performance measures. In particular, we discuss: 1) how historical data already gives some indication of connection between human performance and overall plant performance, 2) how industry led efforts to measure and model human performance and organizational factors could serve as a data source and basis for a framework, 3) how our use of modeling and simulation techniques could be used to develop and validate measures of human performance, and 4) what the possible outcomes are from this research as the modeling and simulation efforts generate results.

Jeffrey Joe; Bruce Hallbert; Larry Blackwood; Donald Dudehoeffer; Kent Hansen

2006-05-01T23:59:59.000Z

335

Time, Humans and Societal Challenges  

E-Print Network [OSTI]

,000 (human development) Since 1850 (industrial revolution Since 1950 (population explosion) Sustainable

336

Human hybrid hybridoma  

SciTech Connect (OSTI)

Hybrid hybridomas are obtained by fusion of two cells, each producing its own antibody. Several authors have reported the construction of murine hybrid hybridomas with the aim to obtain bispecific monoclonal antibodies. The authors have investigated, in a model system, the feasibility of constructing a human hybrid hybridoma. They fused two monoclonal cell lines: an ouabain-sensitive and azaserine/hypoxanthine-resistant Epstein-Barr virus-transformed human cell line that produces an IgG1kappa antibody directed against tetanus toxiod and an azaserine/hypoxanthine-sensitive and ouabain-resistant human-mouse xenohybrid cell line that produces a human IgG1lambda antibody directed against hepatitis-B surface antigen. Hybrid hybridoma cells were selected in culture medium containing azaserine/hypoxanthine and ouabain. The hybrid nature of the secreted antibodies was analyzed by means of two antigen-specific immunoassay. The results show that it is possible, with the combined use of transformation and xenohybridization techniques, to construct human hybrid hybridomas that produce bispecific antibodies. Bispecific antibodies activity was measured by means of two radioimmunoassays.

Tiebout, R.F.; van Boxtel-Oosterhof, F.; Stricker, E.A.M.; Zeijlemaker, W.P.

1987-11-15T23:59:59.000Z

337

Evaluation of the Effects of Green Tea Extracts on Bone Homeostasis in the Ts65Dn Down Syndrome Mouse Model  

E-Print Network [OSTI]

Evaluation of the Effects of Green Tea Extracts on Bone Homeostasis in the Ts65Dn Down Syndrome- gallate (EGCG), an aromatic polyphenol found in high concentrations in green tea, is a known inhibitor

Zhou, Yaoqi

338

Gary M. Bone, Andrew Lambert and Mark Edwards Abstract This paper describes the development of a novel  

E-Print Network [OSTI]

Gary M. Bone, Andrew Lambert and Mark Edwards Abstract ­ This paper describes the development from the top of a pile was described by Taylor, Blake and Cox [3]. They used a wrist-mounted camera

Bone, Gary

339

Potential commercial application of a bi-layer bone-ligament regeneration scaffold to anterior cruciate ligament replacement  

E-Print Network [OSTI]

A business model was created in order to explore the commercial application of a bi-layer bone-ligament scaffold to the treatment of torn anterior cruciate ligaments (ACL) requiring replacement. The two main keys in producing ...

Li, Jessica C. (Jessica Ching-Yi)

2006-01-01T23:59:59.000Z

340

CANDU human performance analysis  

SciTech Connect (OSTI)

An evaluation of human performance is presented in this paper in the context of the operational safety management system. To focus on problems, an experience review program has been developed to establish trends, demonstrate the degree of compliance with standards, and determine the causes of poor performance. The primary method by which the experience review takes place is significant event reporting (SER). A significant event is an incident that causes an undesirable effect on safety, product quality, environmental protection, or product cost. In spite of advanced technology and the degree of automation of the Canada deuterium uranium (CANDU) design, mistakes and malfunctions to occur. Considerable effort has been made to prevent or reduce the incidence of error. The Institute of Nuclear Power Operations developed a system to analyze human error, called the Human Performance Evaluation System (HPES). To encourage an open exchange of information, the system is anonymous and nonpunitive. All data gathered during HPES evaluations are kept confidential.

Walker, I.

1987-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Effect of irradiation on bone remodelling and the structural integrity of the vertebral column. Doctoral thesis  

SciTech Connect (OSTI)

The effects of therapeutic levels of radiation on the axial properties of the primate vertebral column were studied. Seven male rhesus monkeys (Macaca mulatta) were irradiated with a single does of 1300 cGy to the specific lumbar vertebrae of L2, L3, and L4. Three additional animals served as controls. Radiographs were taken before the radiation treatment and just prior to sacrifice to determine density changes in the bone. The animal subjects were sacrificed 105 days following the radiation exposure. Biomechanical testing was completed on lumbar levels 2 and 3 to identify changes in strength characteristics following radiation treatment. Histomorphometric analysis of lumbar vertebrae level 4 was completed to identify volume and surface density changes as well as cellular changes. Tetracycline, dicarbomethylaminomethyl fluorescein (DCAF), and xylenol orange were used as bone labeling agents to aid in the histomorphometry and to obtain dynamic parameter changes.

Swenson, K.N.

1990-01-01T23:59:59.000Z

342

Characterization of host lymphoid cells in antibody-facilitated bone marrow chimeras  

SciTech Connect (OSTI)

The authors have produced stable murine antibody-facilitated (AF) chimeras by the simultaneous injection of P1 bone marrow cells and anti-P2 monoclonal antibody into normal (unirradiated) adult (P1 X P2)F1 recipients. These AF chimeras are healthy, long-lived, and exhibit no overt signs of graft-versus-host disease. They are immunocompetent and tolerant of host, P2-encoded alloantigens. Donor cell engraftment and takeover, monitored by glucosephosphate isomerase isozyme patterns, is usually complete (greater than 95%) in the peripheral blood, bone marrow, and hemopoietic stem cell compartments of long-term (greater than 3 months posttransplantation) AF chimeras. The authors report here, however, that splenic, lymph node, and thymic leukocytes of AF chimeras represent donor/host chimeric populations. Spleen cell populations of AF chimeras exhibit substantial chimera-to-chimera variation in the preponderant residual host cell type(s) present. Interpretations of the implications of these findings are discussed.

McCarthy, S.A.; Griffith, I.J.; Gambel, P.; Francescutti, L.H.; Wegmann, T.G.

1985-07-01T23:59:59.000Z

343

Intra-arterial Autologous Bone Marrow Cell Transplantation in a Patient with Upper-extremity Critical Limb Ischemia  

SciTech Connect (OSTI)

Induction of therapeutic angiogenesis by autologous bone marrow mononuclear cell transplantation has been identified as a potential new option in patients with advanced lower-limb ischemia. There is little evidence of the benefit of intra-arterial cell application in upper-limb critical ischemia. We describe a patient with upper-extremity critical limb ischemia with digital gangrene resulting from hypothenar hammer syndrome successfully treated by intra-arterial autologous bone marrow mononuclear cell transplantation.

Madaric, Juraj, E-mail: jurmad@hotmail.com [National Institute of Cardiovascular Diseases (NUSCH) and Slovak Medical University, Department of Cardiology and Angiology (Slovakia)] [National Institute of Cardiovascular Diseases (NUSCH) and Slovak Medical University, Department of Cardiology and Angiology (Slovakia); Klepanec, Andrej [National Institute of Cardiovascular Diseases, Department of Diagnostic and Interventional Radiology (Slovakia)] [National Institute of Cardiovascular Diseases, Department of Diagnostic and Interventional Radiology (Slovakia); Mistrik, Martin [Clinic of Hematology and Transfusiology, Faculty Hospital (Slovakia)] [Clinic of Hematology and Transfusiology, Faculty Hospital (Slovakia); Altaner, Cestmir [Slovak Academy of Science, Institute of Experimental Oncology (Slovakia)] [Slovak Academy of Science, Institute of Experimental Oncology (Slovakia); Vulev, Ivan [National Institute of Cardiovascular Diseases, Department of Diagnostic and Interventional Radiology (Slovakia)] [National Institute of Cardiovascular Diseases, Department of Diagnostic and Interventional Radiology (Slovakia)

2013-04-15T23:59:59.000Z

344

Human MSH2 protein  

DOE Patents [OSTI]

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

de la Chapelle, Albert (Helsingfors, FI); Vogelstein, Bert (Baltimore, MD); Kinzler, Kenneth W. (Baltimore, MD)

1997-01-01T23:59:59.000Z

345

Human MSH2 protein  

DOE Patents [OSTI]

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.

Chapelle, A. de la; Vogelstein, B.; Kinzler, K.W.

1997-01-07T23:59:59.000Z

346

Automatic detection of bone fragments in poultry using multi-energy x-rays  

DOE Patents [OSTI]

At least two linear arrays of x-ray detectors are placed below a conveyor belt in a poultry processing plant. Multiple-energy x-ray sources illuminate the poultry and are detected by the detectors. Laser profilometry is used to measure the poultry thickness as the x-ray data is acquired. The detector readout is processed in real time to detect the presence of small highly attenuating fragments in the poultry, i.e., bone, metal, and cartilage.

Gleason, Shaun S. (Knoxville, TN); Paulus, Michael J. (Knoxville, TN); Mullens, James A. (Knoxville, TN)

2002-04-09T23:59:59.000Z

347

Treatment of Extraspinal Painful Bone Metastases with Percutaneous Cementoplasty: A Prospective Study of 50 Patients  

SciTech Connect (OSTI)

The aim of this study was to assess the efficacy of percutaneous cementoplasty (PC) with polymethylmethacrylate (PMMA) in painful extravertebral lytic bone metastases not responding to conventional therapy. Fifty patients (25 females), mean age 64.7 {+-} 11.2 years, underwent PC after giving informed consent. Procedures were performed under fluoroscopy (1/50) or combined fluoroscopy-CT (49/50) guidance in local anesthesia or under deep sedation in 7 patients with large metastases who underwent radiofrequency thermoablation (RFA) in the same session. Seventy lesions were treated (1-6 per patient; average, 1.4 {+-} 0.9), arranging in size from 1 to 10 cm (average, 3.6 {+-} 2.1 cm). Mean volume of PMMA per lesion was 5.9 {+-} 3.2 ml (range, 1.5-15.0 ml). Pain was prospectively evaluated on an 11-point visual analog scale (VAS) before and after the procedure (follow-up, 15 to 36 months). Mean VAS score dropped from 9.1 {+-} 1.2 (range: 6-10) to 2.1 {+-} 2.5 (range: 0-9). Mean VAS difference was 7.0 {+-} 2.3 (range, 1-10; p < 0.0001, Wilcoxon signed rank test). Forty-seven of the 50 patients (94%) suspended narcotic drugs, in 22 (44%) pain was controlled with a nonsteroidal anti-inflammatory drug, in 25 (50%) analgesic therapy was suspended, and 13 of 50 (26%) had complete pain regression. In 3 of the 50 patients (6%) pain was not improved. No statistical difference between osteoplasty and osteoplasty plus RFA was found (p = 0.8338, Mann-Whitney test). No complications arose during the procedure. Two patients with metastases in the femoral diaphysis reported a fracture 1 month after treatment. PC is effective to obtain pain regression in painful bone metastases not responding to conventional analgesic therapy; bone consolidation cannot be obtained in the diaphysis of long weight-bearing bones.

Anselmetti, Giovanni Carlo, E-mail: giovanni.anselmetti@ircc.it; Manca, Antonio [Institute for Cancer Research and Treatment, Interventional Radiology Unit (Italy); Ortega, Cinzia; Grignani, Giovanni [Institute for Cancer Research and Treatment, Oncology Unit (Italy); DeBernardi, Felicino [Institute for Cancer Research and Treatment, Anesthesiology Unit (Italy); Regge, Daniele [Institute for Cancer Research and Treatment, Radiology Unit (Italy)

2008-11-15T23:59:59.000Z

348

Bone Implant Interface Investigation by Synchrotron Radiation X-Ray Microfluorescence  

SciTech Connect (OSTI)

Zinc is known to play a relevant role in growth and development; it has stimulatory effects on in vitro and in vivo bone formation and an inhibitory effect on in vitro osteoclastic bone resorption. The inorganic component of the bone tissue is nonstoichiometric apatite; changes in the composition of hidroxyapatite are subject of studies in order to improve the tissue response after implantation. The objective of this study was to investigate the effect of 0.5% zinc-containing hydroxyapatite in comparison to hydroxyapatite on osseous repair of rabbit's tibia. Cylinders (2x6 mm) of both materials were produced according to the specification of the International Organization for Standardization. Ethics Commission on Teaching and Research in Animals approved this project (HUAP-195/06). Fifteen White New Zealand rabbits were submitted to general anesthesia and two perforations (2 mm) were made in each tibia for implantation of zinc-containing hydroxyapatite cylinders (left tibia) and hydroxyapatite cylinders (right tibia). After 1, 2 and 4 weeks, the animals were killed and one fragment of each tibia with the cylinder was collected and embedded in a methacrylate-based resin and cut into slices (approx200 {mu}m thickness), parallel to the implant's long axis with a precision diamond saw for Synchrotron Radiation X-ray Microfluorescence investigation. The accomplishment of the standard procedures helped the planning, execution and the comparative analysis of the results. The chemical and physical properties of the biomaterials were modified after its implantation and the incorporation of zinc. Both materials are biocompatible and promote osteoconduction and favored bone repair.

Calasans-Maia, M. [Odondology Department, Fluminense Federal Univeristy, Niteroi 24030-900, RJ (Brazil); Sales, E.; Lopes, R. T. [Nuclear Instrumentation Laboratory-PEN/COPPE, Federal Univeristy of Rio de Janeiro, Rio de Janeiro 21941-914, RJ (Brazil); Granjeiro, J. M. [Department of Cell and Molecular Biology, Fluminense Federal University, Niteroi 24030-900, RJ (Brazil); Lima, I. [Odondology Department, Fluminense Federal Univeristy, Niteroi 24030-900, RJ (Brazil); Department of Mechanical Engineering and Energy, Rio de Janeiro State University, Regional Campus-Polytechnic Institute-Alberto Rangel, s/n, Vila Nova, room 308, 28630-050, Nova Friburgo, RJ (Brazil)

2010-04-06T23:59:59.000Z

349

Revised estimates of electron absorbed fractions and radionuclide S-values in trabecular bone  

E-Print Network [OSTI]

OF CONTENTS LIST OF TABLES LIST OF FIGURES CHAPTER vnt tX INTRODUCTION . Need for Trabecular Bone Dosimetry Trabecular Bon- Stntcture Cells at Risk . 1 3 5 II THE MIRD SCHEMA Absorbed Dose . Equation Parameters and Full Equations . . 9 11 III... most at risk, while for lower energy P- particles the osteogenic tissue and epithelial layer will be more at risk (ICRP 1968). CHAPTER H THE MIRD SCHEMA Absorbed Dose Radiopharmaceuticals in medicine are being used in imaging, therapy...

Parry, Robert Alan

1995-01-01T23:59:59.000Z

350

Functional Interference Clusters in Cancer Patients With Bone Metastases: A Secondary Analysis of RTOG 9714  

SciTech Connect (OSTI)

Purpose: To explore the relationships (clusters) among the functional interference items in the Brief Pain Inventory (BPI) in patients with bone metastases. Methods: Patients enrolled in the Radiation Therapy Oncology Group (RTOG) 9714 bone metastases study were eligible. Patients were assessed at baseline and 4, 8, and 12 weeks after randomization for the palliative radiotherapy with the BPI, which consists of seven functional items: general activity, mood, walking ability, normal work, relations with others, sleep, and enjoyment of life. Principal component analysis with varimax rotation was used to determine the clusters between the functional items at baseline and the follow-up. Cronbach's alpha was used to determine the consistency and reliability of each cluster at baseline and follow-up. Results: There were 448 male and 461 female patients, with a median age of 67 years. There were two functional interference clusters at baseline, which accounted for 71% of the total variance. The first cluster (physical interference) included normal work and walking ability, which accounted for 58% of the total variance. The second cluster (psychosocial interference) included relations with others and sleep, which accounted for 13% of the total variance. The Cronbach's alpha statistics were 0.83 and 0.80, respectively. The functional clusters changed at week 12 in responders but persisted through week 12 in nonresponders. Conclusion: Palliative radiotherapy is effective in reducing bone pain. Functional interference component clusters exist in patients treated for bone metastases. These clusters changed over time in this study, possibly attributable to treatment. Further research is needed to examine these effects.

Chow, Edward, E-mail: Edward.Chow@sunnybrook.c [Odette Cancer Centre, Toronto, ON (Canada); James, Jennifer [RTOG Statistical Center, Philadelphia, PA (United States); Barsevick, Andrea [Fox Chase Cancer Center, Cheltenham, PA (United States); Hartsell, William [Good Samaritan Cancer Center, Downers Grove, IL (United States); Ratcliffe, Sarah [University of Pennsylvania School of Medicine, Philadelphia, PA (United States); Scarantino, Charles [Rex Healthcare Cancer Center, Raleigh, NC (United States); Ivker, Robert [Newark Beth Israel Medical Center, Newark, NJ (Israel); Roach, Mack [UCSF Comprehensive Cancer Center, San Francisco, CA (United States); Suh, John [Cleveland Clinic Foundation, Cleveland, OH (United States); Petersen, Ivy [Mayo Clinic, Rochester, MN (United States); Konski, Andre [Fox Chase Cancer Center, Cheltenham, PA (United States); Demas, William [Akron City Hospital Cancer Care Center, Inc., Akron, OH (United States); Bruner, Deborah [Abramson Cancer Center, Philadelphia, PA (United States)

2010-04-15T23:59:59.000Z

351

Immunization with FSH? fusion protein antigen prevents bone loss in a rat ovariectomy-induced osteoporosis model  

SciTech Connect (OSTI)

Highlights: •A GST-FSH fusion protein was successfully expressed in E. coli. •Immunization with GST-FSH antigen can raise high-titer anti-FSH polyclonal sera. •Anti-FSH polyclonal sera can neutralize osteoclastogenic effect of FSH in vitro. •FSH immunization can prevent bone loss in a rat osteoporosis model. -- Abstract: Osteoporosis, a metabolic bone disease, threatens postmenopausal women globally. Hormone replacement therapy (HTR), especially estrogen replacement therapy (ERT), is used widely in the clinic because it has been generally accepted that postmenopausal osteoporosis is caused by estrogen deficiency. However, hypogonadal ? and ? estrogen receptor null mice were only mildly osteopenic, and mice with either receptor deleted had normal bone mass, indicating that estrogen may not be the only mediator that induces osteoporosis. Recently, follicle-stimulating hormone (FSH), the serum concentration of which increases from the very beginning of menopause, has been found to play a key role in postmenopausal osteoporosis by promoting osteoclastogenesis. In this article, we confirmed that exogenous FSH can enhance osteoclast differentiation in vitro and that this effect can be neutralized by either an anti-FSH monoclonal antibody or anti-FSH polyclonal sera raised by immunizing animals with a recombinant GST-FSH? fusion protein antigen. Moreover, immunizing ovariectomized rats with the GST-FSH? antigen does significantly prevent trabecular bone loss and thereby enhance the bone strength, indicating that a FSH-based vaccine may be a promising therapeutic strategy to slow down bone loss in postmenopausal women.

Geng, Wenxin; Yan, Xingrong; Du, Huicong; Cui, Jihong; Li, Liwen, E-mail: liven@nwu.edu.cn; Chen, Fulin, E-mail: chenfl@nwu.edu.cn

2013-05-03T23:59:59.000Z

352

Human Processing (Position Paper)  

E-Print Network [OSTI]

and describe remaining challenges in the area (Section 6). 2. MOTIVATING EXAMPLE "Priam," the editor below, we explain how Priam might go about accomplishing this task. Figure 1: Basic Buyer human. The programmer (Priam) writes a normal program. 2. That program can, in the course of execution, create HTML

Chang, Edward Y.

353

transforming human health  

E-Print Network [OSTI]

transforming human health AnnUAl REpoRt 2011­2012 #12;#12;how we're changing medical research 1 are transforming health. He proposed an entirely new theory for developing drugs to treat diseases that have malaria and solid tumors such as lung and breast cancers are in development. #12;A TrAnsformATive educ

Kenny, Paraic

354

Human sciences The human sciences database contains approximately 254 academic  

E-Print Network [OSTI]

Human sciences The human sciences database contains approximately 254 academic journals and statistical reports on the following subjects: (comparative literature, theology, history and geography, education, psychology, arts, languages and Library Science) Social sciences The social sciences database

355

Human-elephant conflicts; Human-elephant conflicts.  

E-Print Network [OSTI]

?? It is widely recognized that human-wildlife conflicts can reduce farmers’ support for long-term species conservation. The subject of human-elephant conflicts is highly relevant in… (more)

Olsson, Linnea

2014-01-01T23:59:59.000Z

356

Policy on Human Subjects Research Policy on Human Subjects  

E-Print Network [OSTI]

Policy on Human Subjects Research 10/15/2014 Policy on Human Subjects Research I. Purpose and Scope requirements that the rights and welfare of human subjects receive adequate protection. This policy applies, except that research conducted or assigned as part of their coursework is governed by the Policy

Sridhar, Srinivas

357

Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standard  

E-Print Network [OSTI]

slice MDCT . HR-pQCT . Osteoporosis . Structure analysis .bone Introduction Osteoporosis is defined as a systemicmethod in current osteoporosis diagnosis is the assessment

2010-01-01T23:59:59.000Z

358

Human Capital Management Accountability Program  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The Order establishes requirements, roles and responsibilities for the Human Capital Management Accountability Program (HCMAP) for human resources programs and personnel and ensures that human capital activities are regulatory and procedurally compliant with Federal statutes and Departmental policies. Does not cancel other directives.

2008-08-01T23:59:59.000Z

359

Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice  

E-Print Network [OSTI]

Adoptive transfer of human hematopoietic stem cells (HSCs) into mice lacking T, B and natural killer (NK) cells leads to development of human-blood lineage cells in the recipient mice (humanized mice). Although human B ...

Chen, Qingfeng

360

E-Print Network 3.0 - assessing biomechanical exposures Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

. Biomechanics of cortical and trabecular bone: implications for assessment of fracture risk 3. Modeling... BME 473 Applied Biomechanics Every Spring Semester 2004-2005...

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Expression of T cell antigen receptor genes in the thymus of irradiated mice after bone marrow transplantation  

SciTech Connect (OSTI)

Sequential appearance of the expression of T cell antigen receptor genes was investigated in the thymus of irradiated mice at the early stage after transplantation of Thy-1 congeneic H-2 compatible allogeneic bone marrow cells. The first cells to repopulate the thymus on day 7 after bone marrow transplantation were intrathymic radioresistant T cell precursors, which expanded mainly to CD4+CD8+ host-type thymocytes by day 14. A high level of gamma gene expression but a much reduced level of alpha and beta gene expression were detected in the host-type thymocytes on day 7. During regeneration of these cells, gamma-chain messages fell to low level and alpha and beta mRNA levels increased. The thymus of the recipients began to be repopulated by donor-derived T cells about 2 wk after bone marrow transplantation and was almost completely replaced by the third week. An ordered expression of gamma then beta and alpha-chain gene transcript was also observed in the donor-type thymocytes at the early stage after bone marrow transplantation. The use of thymocytes at early stage in whole-body irradiated bone marrow chimera provides a pertinent source for investigating the molecular mechanism of T cell differentiation in adult thymus.

Matsuzaki, G.; Yoshikai, Y.; Kishihara, K.; Nomoto, K.

1988-01-15T23:59:59.000Z

362

The reproducibility of [sup 109]Cd-based X-ray fluorescence measurements of bone lead  

SciTech Connect (OSTI)

We assessed the reproducibility of X-ray fluorescence-based lead measurements from multiple measurements made on a low-concentration plaster of paris phantom and in five subjects measured five times on two occasions. Over a 6-month period, 220 measurements of the same phantom were obtained and showed a standard deviation of 1.29 [mu]g Pb (g plaster of paris)[sup [minus]1]. The two sets of in vivo measurements were made 10 months apart and revealed a mean standard deviation of 3.4 [mu]Pb (g bone mineral)[sup [minus]1] and 5.1 [mu]g Pb (g bone mineral)[sup [minus]1] for males and females, respectively. Our measured standard deviation exceeded by 20-30% the calculated standard deviation associated with a single measurement both in the phantom and in subjects. This indicates that some variance is introduced during the measurement process. Operator learning and consistency significantly minimized this increased variability. Measured lead concentrations of the left and right tibia in 14 subjects showed no significant differences between legs. As a result, either tibia can be sampled and compared over time. The levels of reproducibility we report here mean that X-ray fluorescence-based determinations of bone lead concentrations are reliable both over the short and long term. Thus, reasonably sized confidence intervals can be placed on detected changes in concentration and should permit acquisition of longitudinal data within a reasonable length of time. 19 refs., 1 fig., 6 tabs.

Gordon, C.L. (Chedoke-McMaster Hospitals, Hamilton, Ontario (Canada)); Webber, C.E.; Chettle, D.R. (McMaster Univ., Hamilton, Ontario (Canada))

1994-08-01T23:59:59.000Z

363

A parametric analysis of bone fixation plates on fractured equine third metacarpal  

E-Print Network [OSTI]

of metallic materials, were also being investigated and tried clinically. The earliesr types of metal plates to be used were made of nickel-steel, iron, or silver (1). These early plates were generally attached to the fractured Numbers in parentheses...A P~TRIC ANALYSIS OI' BONE FIXATION PLATES ON FRACTURED EQUINE THIRD lKTACARPAL A Thesis by Donald Reagan Ray Submitted to tnk Graduate College of Texas A&N University in partial fulfillment of the requirement for the degree of MASTER...

Ray, Donald Reagan

1970-01-01T23:59:59.000Z

364

Calcium balance and bone density in immature horses fed a high protein diet  

E-Print Network [OSTI]

injuries were also found to occur most often in animals aged 2-4 years (Johnson et al., 1994). Even in cases where complete bone failure does not occur, skeletal injuries are more common in young animals. Norwood (1978) reported as many as 70% of two...; however, protein- restricted diets may result in lower blood pH post-exercise (Graham-Theirs et al., 2001). No diet or diet*day effect was seen on blood pH at a significance of p < 0.05. While this does not seem to support an acidogenic effect...

Spooner, Holly Sue

2006-10-30T23:59:59.000Z

365

Long bone growth of Mimbres subadults from the NAN Ranch (LA15049), New Mexico  

E-Print Network [OSTI]

of 559 skeletons from three time periods (Late Woodland, Mississippian Acculturated Late Woodland, and Table 2. 2. Indian Knoll maximum long bone length (cm) without epiphysis*. 10 13 14 15 16 17 18 2. 5 ? 3. 5 yr. 3. 5 ? 4. 5 yr. 4. 5 ? 5. 5... yr. 5. 5 ? 6. 5 yr. 6. 5 ? 8 yr. 8 ? 10. 5 yr. 10. 5 ? 11 yr. 11 ? 12 yr. 12 yl ~ 15 yr. + 6 mo. 15 yr. 16 yz' ~ 16. 5 ? 17 yr. 21 yr ~ Age Group Age 1 Birth ? 6 mo. 6 ? 15 mo. 15 ? 24 mo. 4 2 ? 2. 5 yr. Humerus N Mean SD Range 5...

Marek, Marianne

2012-06-07T23:59:59.000Z

366

Lead effects on development and function of bone marrow-derived dendritic cells promote Th2 immune responses  

SciTech Connect (OSTI)

Although lead (Pb) has significant effects on the development and function of macrophages, B cells, and T cells and has been suggested to promote allergic asthma in mice and humans, Pb modulation of bone marrow (BM)-derived dendritic cells (DCs) and the resultant DC effects on Th1 and Th2 development have not been examined. Accordingly, we cultured BM cells with murine granulocyte macrophage-colony stimulating factor (mGM-CSF) {+-} PbCl{sub 2}. At day 10, culture supernatant (SN) and non-adherent cells were harvested for analysis. Additionally, day 10 non-adherent BM-DCs were harvested and recultured with mGM-CSF + LPS {+-} Pb for 2 days. The day 10 Pb exposure significantly inhibited BM-DC generation, based on CD11c expression. Although fewer DCs were generated with Pb, the existing Pb-exposed DCs had significantly greater MHC-II expression than did the non-Pb-exposed DCs. However, these differences diminished upon LPS stimulation. After LPS stimulation, CD80, CD86, CD40, CD54, and MHC-II were all up-regulated on both Pb-DCs and DCs, but Pb-DCs expressed significantly less CD80 than did DCs. The CD86:CD80 ratio suggests a Pb-DC potential for Th2 cell development. After LPS stimulation, IL-6, IL-10, IL-12 (p70), and TNF-{alpha} levels significantly increased with both Pb-DCs and DCs, but Pb-DCs produced significantly less cytokines than did DCs, except for IL-10, which further supports Pb-DC preferential skewing toward type-2 immunity. In vitro studies confirm that Pb-DCs have the ability to polarize antigen-specific T cells to Th2 cells. Pb-DCs also enhanced allogeneic and autologous T cell proliferation in vitro, and in vivo studies suggested that Pb-DCs inhibited Th1 effects on humoral and cell-mediated immunity. The Pb effect was mainly on DCs, rather than on T cells, and Pb's modification of DC function appears to be the main cause of Pb's promotion of type-2-related immunity, which may relate to Pb's enhanced activation of the Erk/MAP kinase pathway.

Gao Donghong [Biggs Laboratory, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201-0509 (United States); Mondal, Tapan K. [Biggs Laboratory, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201-0509 (United States); Lawrence, David A. [Biggs Laboratory, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201-0509 (United States)]. E-mail: lawrencd@wadsworth.org

2007-07-01T23:59:59.000Z

367

Human Resources Organizational Development and Training 1  

E-Print Network [OSTI]

Human Resources Organizational Development and Training 1 Development Guide for Tufts Leadership Competencies Human Resources Training, Learning and Development Copyright © 2013 Tufts University Developed with Copperbeech Group Inc. #12;Human Resources Training, Learning and Development 2 #12;Human Resources Training

Dennett, Daniel

368

Essential requirement of I-A region-identical host bone marrow or bone marrow-derived cells for tumor neutralization by primed L3T4+ T cells  

SciTech Connect (OSTI)

The antitumor activity of Meth A-hyperimmunized BALB/c mouse spleen cells (Meth A-Im-SPL) was assayed by the Winn test in H-2 incompatible bone marrow chimeras in closed colony CD-1 (nu/nu), inbred DDD/1(nu/nu) (H-2s), or inbred BALB/c(nu/nu) (H-2d) mice as recipients. We found that Meth A-Im-SPL suppressed Meth A growth in the chimera nude mice which were reconstituted with bone marrow cells of the H-2d haplotype (i.e., BALB/c, DBA/2 and B10.D2), but not in the chimeras which were reconstituted with bone marrow cells of the H-2a, H-2b, or H-2k haplotype (i.e., B10.A, B10, and B10.BR). These results suggested that H-2 restriction occurred between Meth A-Im-SPL and bone marrow or bone marrow-derived cells in tumor neutralization. Furthermore, Meth A-Im-SPL did not suppress Meth 1 tumors (antigenically distinct from Meth A tumors) in the presence or absence of mitomycin C-treated Meth A in a Winn assay. These results suggested that there is tumor specificity in the effector phase as well as in the induction phase. The phenotype of the effectors in the Meth A-Im-SPL was Thy-1.2+ and L3T4+, because Meth A-Im-SPL lost their antitumor activity with pretreatment with anti-Thy-1.2 monoclonal antibody (mAb) and complement or anti-L3T4 mAb and complement, but not with anti-Lyt-2.2 mAb and complement or complement alone. Positively purified L3T4+ T cells from Meth A-Im-SPL (Meth A-Im-L3T4), obtained by the panning method, suppressed the tumor growth in the chimera nude mice which were reconstituted with bone marrow cells of B10.KEA2 mice (that were I-A region-identical with Meth A-Im-L3T4 cells but not others in H-2) as well as B10.D2 cells (that were fully identical with Meth A-Im-L3T4 cells in H-2). We conclude that Meth A-Im-SPL (L3T4+) neutralized the tumors in collaboration with I-A region-identical host bone marrow or bone marrow-derived cells, and the neutralization was not accompanied by the bystander effect.

Ozawa, H.; Iwaguchi, T.; Kataoka, T.

1987-12-01T23:59:59.000Z

369

Mentoring Human Performance - 12480  

SciTech Connect (OSTI)

Although the positive effects of implementing a human performance approach to operations can be hard to quantify, many organizations and industry areas are finding tangible benefits to such a program. Recently, a unique mentoring program was established and implemented focusing on improving the performance of managers, supervisors, and work crews, using the principles of Human Performance Improvement (HPI). The goal of this mentoring was to affect behaviors and habits that reliably implement the principles of HPI to ensure continuous improvement in implementation of an Integrated Safety Management System (ISMS) within a Conduct of Operations framework. Mentors engaged with personnel in a one-on-one, or one-on-many dialogue, which focused on what behaviors were observed, what factors underlie the behaviors, and what changes in behavior could prevent errors or events, and improve performance. A senior management sponsor was essential to gain broad management support. A clear charter and management plan describing the goals, objectives, methodology, and expected outcomes was established. Mentors were carefully selected with senior management endorsement. Mentors were assigned to projects and work teams based on the following three criteria: 1) knowledge of the work scope; 2) experience in similar project areas; and 3) perceived level of trust they would have with project management, supervision, and work teams. This program was restructured significantly when the American Reinvestment and Recovery Act (ARRA) and the associated funding came to an end. The program was restructured based on an understanding of the observations, attributed successes and identified shortfalls, and the consolidation of those lessons. Mentoring the application of proven methods for improving human performance was shown effective at increasing success in day-to-day activities and increasing confidence and level of skill of supervisors. While mentoring program effectiveness is difficult to measure, and return on investment is difficult to quantify, especially in complex and large organizations where the ability to directly correlate causal factors can be challenging, the evidence presented by Sydney Dekker, James Reason, and others who study the field of human factors does assert managing and reducing error is possible. Employment of key behaviors-HPI techniques and skills-can be shown to have a significant impact on error rates. Our mentoring program demonstrated reduced error rates and corresponding improvements in safety and production. Improved behaviors are the result, of providing a culture with consistent, clear expectations from leadership, and processes and methods applied consistently to error prevention. Mentoring, as envisioned and executed in this program, was effective in helping shift organizational culture and effectively improving safety and production. (authors)

Geis, John A.; Haugen, Christian N. [CALIBRE Systems, Inc., Alexandria, Virginia (United States)

2012-07-01T23:59:59.000Z

370

Human Genome Program  

SciTech Connect (OSTI)

The DOE Human Genome program has grown tremendously, as shown by the marked increase in the number of genome-funded projects since the last workshop held in 1991. The abstracts in this book describe the genome research of DOE-funded grantees and contractors and invited guests, and all projects are represented at the workshop by posters. The 3-day meeting includes plenary sessions on ethical, legal, and social issues pertaining to the availability of genetic data; sequencing techniques, informatics support; and chromosome and cDNA mapping and sequencing.

Not Available

1993-01-01T23:59:59.000Z

371

Human Resources | Jefferson Lab  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickr FlickrGuidedCH2MLLC HistoryVeteransto getEmployee Relations Human

372

Human Genome: DOE Origins  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinement plasmas inPortalAllBPA addressesHowHughHumanDecoding

373

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesB PrivacyAugust 1,Human Resources

374

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesB PrivacyAugust 1,Human

375

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesB PrivacyAugust 1,HumanAppraisal

376

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesBQuestions aboutHuman Resources

377

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesBQuestions aboutHuman Resources

378

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesBQuestions aboutHuman ResourcesCode

379

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesBQuestions aboutHuman ResourcesCode

380

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesBQuestions aboutHuman

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Jefferson Lab Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFunInfraredJefferson Lab Click on theJamesBQuestions aboutHumanAppraisal

382

PIA - Human Resources - Personal Information Change Request ...  

Office of Environmental Management (EM)

PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory PIA - Human Resources - Personal Information Change Request - Idaho National...

383

Human subjects research handbook: Protecting human research subjects. Second edition  

SciTech Connect (OSTI)

This handbook serves as a guide to understanding and implementing the Federal regulations and US DOE Orders established to protect human research subjects. Material in this handbook is directed towards new and continuing institutional review board (IRB) members, researchers, institutional administrators, DOE officials, and others who may be involved or interested in human subjects research. It offers comprehensive overview of the various requirements, procedures, and issues relating to human subject research today.

NONE

1996-01-30T23:59:59.000Z

384

C&EN: Latest News -Biopolymer Gives Strength To Bones http://pubs.acs.org/cen/news/83/i30/8330notw6.html 1 of 2 7/31/2005 2:51 PM  

E-Print Network [OSTI]

HALFORD STRETCHED When under stress, bone's biopolymeric glue stretches by breaking sacrificial bonds (red to healthy, fracture-resistant bones may lie within tiny bits of a shock- absorbing biopolymeric "glue

Hansma, Paul

385

Effect of the {delta}-aminolevulinate dehydratase polymorphism on the accumulation of lead in bone and blood in lead smelter workers  

SciTech Connect (OSTI)

Lead inhibition of the zinc metalloenzyme {delta}-aminolevulinate dehydratase (ALAD) is one of the most sensitive indicators of blood lead levels. Whole blood lead, serum lead, and ALAD genotype were determined for 381 lead smelter workers, including 70 workers expressing the ALAD allele, whose blood lead elevations were observed for more than 20 years of employment. The same employees demonstrated higher serum lead levels. Using a cumulative blood lead index (CBLI) for each worker, based on individual blood lead histories, and in vivo X-ray fluorescence measurements of bone lead to estimate total lead body burden, the slopes of linear relations of bone lead to CBLI were greater for workers homoallelic for ALAD, indicating more efficient uptake of lead from blood into bone. This effect was most significant in calcaneus bone and for workers hired since 1977. Decreased transfer of blood lead into bone in individuals expressing the ALAD allele contrasted with increased blood lead.

Fleming, D.E.B.; Chettle, D.R. [McMaster Univ., Hamilton, Ontario (Canada). Dept. of Physics and Astronomy] [McMaster Univ., Hamilton, Ontario (Canada). Dept. of Physics and Astronomy; Wetmur, J.G.; Desnick, R.J. [Mount Sinai School of Medicine, New York, NY (United States)] [Mount Sinai School of Medicine, New York, NY (United States); Robin, J.P. [Noranda Inc., Montreal, Quebec (Canada)] [Noranda Inc., Montreal, Quebec (Canada); Boulay, D.; Richard, N.S. [Brunswick Mining and Smelting Corp. Ltd., Belledune, New Brunswick (Canada). Occupational Health Services] [Brunswick Mining and Smelting Corp. Ltd., Belledune, New Brunswick (Canada). Occupational Health Services; Gordon, C.L.; Webber, C.E. [Hamilton Health Sciences Corp., Hamilton, Ontario (Canada). Dept. of Nuclear Medicine] [Hamilton Health Sciences Corp., Hamilton, Ontario (Canada). Dept. of Nuclear Medicine

1998-04-01T23:59:59.000Z

386

Human-computer interface  

DOE Patents [OSTI]

The present invention provides a method of human-computer interfacing. Force feedback allows intuitive navigation and control near a boundary between regions in a computer-represented space. For example, the method allows a user to interact with a virtual craft, then push through the windshield of the craft to interact with the virtual world surrounding the craft. As another example, the method allows a user to feel transitions between different control domains of a computer representation of a space. The method can provide for force feedback that increases as a user's locus of interaction moves near a boundary, then perceptibly changes (e.g., abruptly drops or changes direction) when the boundary is traversed.

Anderson, Thomas G.

2004-12-21T23:59:59.000Z

387

Human Reliability Program Workshop  

SciTech Connect (OSTI)

A Human Reliability Program (HRP) is designed to protect national security as well as worker and public safety by continuously evaluating the reliability of those who have access to sensitive materials, facilities, and programs. Some elements of a site HRP include systematic (1) supervisory reviews, (2) medical and psychological assessments, (3) management evaluations, (4) personnel security reviews, and (4) training of HRP staff and critical positions. Over the years of implementing an HRP, the Department of Energy (DOE) has faced various challenges and overcome obstacles. During this 4-day activity, participants will examine programs that mitigate threats to nuclear security and the insider threat to include HRP, Nuclear Security Culture (NSC) Enhancement, and Employee Assistance Programs. The focus will be to develop an understanding of the need for a systematic HRP and to discuss challenges and best practices associated with mitigating the insider threat.

Landers, John; Rogers, Erin; Gerke, Gretchen

2014-05-18T23:59:59.000Z

388

Simulating human behavior for national security human interactions.  

SciTech Connect (OSTI)

This 3-year research and development effort focused on what we believe is a significant technical gap in existing modeling and simulation capabilities: the representation of plausible human cognition and behaviors within a dynamic, simulated environment. Specifically, the intent of the ''Simulating Human Behavior for National Security Human Interactions'' project was to demonstrate initial simulated human modeling capability that realistically represents intra- and inter-group interaction behaviors between simulated humans and human-controlled avatars as they respond to their environment. Significant process was made towards simulating human behaviors through the development of a framework that produces realistic characteristics and movement. The simulated humans were created from models designed to be psychologically plausible by being based on robust psychological research and theory. Progress was also made towards enhancing Sandia National Laboratories existing cognitive models to support culturally plausible behaviors that are important in representing group interactions. These models were implemented in the modular, interoperable, and commercially supported Umbra{reg_sign} simulation framework.

Bernard, Michael Lewis; Hart, Dereck H.; Verzi, Stephen J.; Glickman, Matthew R.; Wolfenbarger, Paul R.; Xavier, Patrick Gordon

2007-01-01T23:59:59.000Z

389

237Poverty and Human Capability Studies Poverty and Human  

E-Print Network [OSTI]

237Poverty and Human Capability Studies Poverty and Human CaPability StudieS (Pov) Core FaCulty: PROFESSORS beCKley*, GOLDSMITH, MARGAND The Shepherd Program for the interdisciplinary Study of Poverty and graduate studies can prepare them as futureprofessionalsandcitizenstoaddresstheproblems of poverty and how

Dresden, Gregory

390

227Poverty and Human Capability Studies Poverty AND HUMAN  

E-Print Network [OSTI]

227Poverty and Human Capability Studies Poverty AND HUMAN CAPABILIty StUDIeS (Pov) Core FACULty: PROFESSORS BeCKLey*, GOLDSMITH, MARGAND The Shepherd Program for the Interdisciplinary Study of Poverty studies can prepare them as future professionals and citizens to address the problems of poverty

Dresden, Gregory

391

Reconstructing Cortical Dynamics with Magnetoencephalography  

E-Print Network [OSTI]

ciently on modern high performance computing clusters. Thiswell-suited to run on high performance computing clusters. Savailability of high performance computing clusters (e.g. ,

Dalal, Sarang S.

2007-01-01T23:59:59.000Z

392

Cortical Microstimulation for Neural Prostheses  

E-Print Network [OSTI]

decreased firing rate (mediated by inhibitory circuits [84])circuit must be able to replace specific contact signals from the trigeminal ganglia with neuronal firing

Venkatraman, Subramaniam

2010-01-01T23:59:59.000Z

393

T cells stimulate catabolic gene expression by the stromal cells from giant cell tumor of bone  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer Two T cell lines stimulate PTHrP, RANKL, MMP13 gene expression in GCT cell cultures. Black-Right-Pointing-Pointer CD40 expressed by stromal cells; CD40L detected in whole tumor but not cultures. Black-Right-Pointing-Pointer Effect of CD40L treatment on GCT cells increased PTHrP and MMP13 gene expression. Black-Right-Pointing-Pointer PTHrP treatment increased MMP13 expression, while inhibition decreased expression. Black-Right-Pointing-Pointer T cells may stimulate GCT stromal cells and promote the osteolysis of the tumor. -- Abstract: The factors that promote the localized bone resorption by giant cell tumor of bone (GCT) are not fully understood. We investigated whether T cells could contribute to bone resorption by stimulating expression of genes for parathyroid hormone-related protein (PTHrP), matrix metalloproteinase (MMP)-13, and the receptor activator of nuclear-factor {kappa}B ligand (RANKL). Two cell lines, Jurkat clone E6-1 and D1.1, were co-cultured with isolated GCT stromal cells. Real-time PCR analyses demonstrated a significant increase of all three genes following 48 h incubation, and PTHrP and MMP-13 gene expression was also increased at 24 h. Further, we examined the expression of CD40 ligand (CD40L), a protein expressed by activated T cells, and its receptor, CD40, in GCT. Immunohistochemistry results revealed expression of the CD40 receptor in both the stromal cells and giant cells of the tumor. RNA collected from whole GCT tissues showed expression of CD40LG, which was absent in cultured stromal cells, and suggests that CD40L is expressed within GCT. Stimulation of GCT stromal cells with CD40L significantly increased expression of the PTHrP and MMP-13 genes. Moreover, we show that inhibition of PTHrP with neutralizing antibodies significantly decreased MMP13 expression by the stromal cells compared to IgG-matched controls, whereas stimulation with PTHrP (1-34) increased MMP-13 gene expression. These results suggest that T cells may potentiate the catabolic effect of GCT.

Cowan, Robert W. [Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada) [Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada); Juravinski Cancer Centre, 699 Concession St., Hamilton, ON, Canada L8V 5C2 (Canada); Ghert, Michelle [Juravinski Cancer Centre, 699 Concession St., Hamilton, ON, Canada L8V 5C2 (Canada) [Juravinski Cancer Centre, 699 Concession St., Hamilton, ON, Canada L8V 5C2 (Canada); Department of Surgery, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada); Singh, Gurmit, E-mail: gurmit.singh@jcc.hhsc.ca [Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada) [Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada); Juravinski Cancer Centre, 699 Concession St., Hamilton, ON, Canada L8V 5C2 (Canada)

2012-03-23T23:59:59.000Z

394

Interspecic scaling of the hindlimb skeleton in lizards, crocodilians, felids and canids: does limb bone shape correlate  

E-Print Network [OSTI]

limb bone shape correlate with limb posture? Richard W. Blob* Committee on Evolutionary Biology-phylogenetic statistical methods and phylogenetically independent contrasts. Comparisons with theoretical models indicate to such an extent that for the femur and tibia safety factors in shear are approximately half as great as safety

Blob, Richard W.

395

Injectable Bone Substitute using a hydrophilic polymer Pierre Weiss, Olivier Gauthier, Jean-Michel Bouler, Gal Grimandi and Guy Daculsi  

E-Print Network [OSTI]

polymer as matrix and bioactive calcium phosphate (CaP) ceramics as fillers. This material is composed effects on this composite in a tube. The stability of the polymer and the mixture is essential between CaP ceramic granules and facilitate the role of the biological agents of bone substitution

Boyer, Edmond

396

Physico-chemical characterization and in vitro biological evaluation of pure SiHA for bone tissue engineering application  

E-Print Network [OSTI]

Supérieure des Mines de Saint-Etienne, CIS-EMSE, CNRS: FRE3312, F-42023 158 Cours Fauriel, SaintHA surface. Introduction Large bone defects resulting from trauma, cancer or malformations remain significant the real effects of Si substitution on the biological activity of HA in biological environment [6-8]. hal

Paris-Sud XI, Université de

397

Fracture Mechanisms of Bone: A Comparative Study between Antler and Bovine Femur , F.A. Sheppard2  

E-Print Network [OSTI]

Fracture Mechanisms of Bone: A Comparative Study between Antler and Bovine Femur P.Y. Chen1 , F, University of California, San Diego, La Jolla, CA 92093-0411, U.S.A. ABSTRACT In this study, fracture conditions to study the effects of fiber orientation and hydration. Fracture toughness results

McKittrick, Joanna

398

Bone Acquisition in Healthy Children and Adolescents: Comparisons of Dual-Energy X-Ray Absorptiometry and  

E-Print Network [OSTI]

and Radiology and Division of Endocrinology and Metabolism, Childrens Hospital Los Angeles, Los Angeles pediatric bone measurements using DXA. Height, weight, body mass index, skeletal age, and Tanner stageBMD in healthy children (2­13). Although DXA studies in pediatrics have provided much information re- garding

Valero-Cuevas, Francisco

399

Effects of bone marrow-derived cells on monocrotaline-and hypoxia-induced pulmonary hypertension in mice  

E-Print Network [OSTI]

hypertension in mice William Raoul,1 Orianne Wagner-Ballon,6 Guitanouch Saber,1 Anne Hulin,5 Elisabeth Marcos the difference in their effects depends on the mechanism of pulmonary hypertension (PH) remains unknown of monocrotaline (MCT)- induced pulmonary hypertension, Zhao et al. [9] showed that bone marrow-derived endothelial

Paris-Sud XI, Université de

400

Prevention of Postmenopausal Bone Loss by a Low-Magnitude, High-Frequency Mechanical Stimuli: A Clinical Trial Assessing Compliance,  

E-Print Network [OSTI]

, skeleton, aging, menopause, bone, antiresorptive INTRODUCTION OSTEOPOROSIS, A DISEASE CHARACTERIZED, double-blind, and placebo-controlled clinical trial in 70 women, 3­8 years past the menopause, examined the potential for a noninvasive, mechanically mediated intervention for osteoporosis. This non

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Bone quality measurements Osteoporos Int. 2011 Aug;22(8):2225-40. New laboratory tools in the assessment  

E-Print Network [OSTI]

,version1-1Jul2013 Author manuscript, published in "Osteoporosis International 22, 8 (2011) 2225-2240" DOI Force Microscopy FEA Finite Element Analysis Introduction Fragility fractures due to osteoporosis and affect ~30 % of women after the menopause and ~10 % of men. Dual Energy bone densitometry (DXA) has

Paris-Sud XI, Université de

402

The human activity of visualization  

E-Print Network [OSTI]

Griffin et al 2006 #12;Human-Computer Interaction: Software of the Mind each user has a setThe human activity of visualization cultural and psychological factors in representation; Gibbon 1998; Marcus 2000) conventions and metaphors of Westerners may not hold worldwide colors

Wright, Dawn Jeannine

403

RECRUITMENT SEARCH FIRMS HUMAN RESOURCES  

E-Print Network [OSTI]

RECRUITMENT SEARCH FIRMS HUMAN RESOURCES GUIDELINES Workforce Planning | Washington Square, San by the Workforce Planning Unit in Human Resources at SJSU. Process Consistent, defensible processes for evaluating of the recruitment. - At this meeting, the Workforce Planning analyst can provide contact information for search

Su, Xiao

404

Suppressor cells in transplantation tolerance. II. maturation of suppressor cells in the bone marrow chimera  

SciTech Connect (OSTI)

Histoincompatible bone marrow allografts were established in lethally irradiated rats. At various times after transplantation, the spleen cells were harvested, subjected to mixed lymphocyte cultures, and assayed for suppressor cells in vitro and in vivo by adoptive transfer studies. Alloantigen-nonspecific suppressor cells appeared in the chimera at 40 days after grafting, coinciding with the resolution of graft-versus-host disease (GVHD). At 250 days the nonspecific suppressor cells were replaced by suppressor cells specifically suppressing donor-versus-host alloantigen responses. At 720 days suppressor cells could no longer be identified by in vitro methods but were identified by in vivo adoptive transfer of transplantation tolerance. After injection of host-type antigen into chimeras, the suppressor cells could be again demonstrated by in vitro methods.

Tutschka, P.J.; Ki, P.F.; Beschorner, W.E.; Hess, A.D.; Santos, G.W.

1981-10-01T23:59:59.000Z

405

Suppressor cells in transplantation tolerance II. Maturation of suppressor cells in the bone marrow chimera  

SciTech Connect (OSTI)

Histoincompatible bone marrow allografts were established in lethally irradiated rats. At various times after transplantation, the spleen cells were harvested, subjected to mixed lymphocyte cultures, and assayed for suppressor cells in vitro and in vivo by adoptive transfer studies. Alloantigen-nonspecific suppressor cells appeared in the chimera at 40 days after grafting, coinciding with the resolution of graft-versus-host disease (GVHD). At 250 days the nonspecific suppressor cells were replaced by suppressor cells specifically suppressing donor-versus-host alloantigen responses. At 720 days suppressor cells could no longer be identified by in vitro methods but were identified by in vivo adoptive transfer of transplantation tolerance. After injection of host-type antigen into chimeras, the suppressor cells could be again demonstrated by in vitro methods.

Tutschka, P.J.; Ki, P.F.; Beschorner, W.E.; Hess, A.D.; Santos, G.W.

1981-10-01T23:59:59.000Z

406

Anti-bacterial immunity to Listeria monocytogenes in allogeneic bone marrow chimera in mice  

SciTech Connect (OSTI)

Protection and delayed-type hypersensitivity (DTH) to the facultative intracellular bacterium Listeria monocytogenes (L.m.) were studied in allogeneic and syngeneic bone marrow chimeras. Lethally irradiated AKR (H-2k) mice were successfully reconstituted with marrow cells from C57BL/10 (B10) (H-2b), B10 H-2-recombinant strains or syngeneic mice. Irradiated AKR mice reconstituted with marrow cells from H-2-compatible B10.BR mice, (BR----AKR), as well as syngeneic marrow cells, (AKR----AKR), showed a normal level of responsiveness to the challenge stimulation with the listeria antigens when DTH was evaluated by footpad reactions. These mice also showed vigorous activities in acquired resistance to the L.m. By contrast, chimeric mice that had total or partial histoincompatibility at the H-2 determinants between donor and recipient, (B10----AKR), (B10.AQR----AKR), (B10.A(4R)----AKR), or (B10.A(5R)----AKR), were almost completely unresponsive in DTH and antibacterial immunity. However, when (B10----AKR) H-2-incompatible chimeras had been immunized with killed L.m. before challenge with live L.m., these mice manifested considerable DTH and resistance to L.m. These observations suggest that compatibility at the entire MHC between donor and recipient is required for bone marrow chimeras to be able to manifest DTH and protection against L.m. after a short-term immunization schedule. However, this requirement is overcome by a preceding or more prolonged period of immunization with L.m. antigens. These antigens, together with marrow-derived antigen-presenting cells, can then stimulate and expand cell populations that are restricted to the MHC (H-2) products of the donor type.

Onoe, K.; Good, R.A.; Yamamoto, K.

1986-06-01T23:59:59.000Z

407

Adaptive differentiation of H-2- and Igh-restricted B lymphocyte in tetraparental bone marrow chimera  

SciTech Connect (OSTI)

Immunization of BALB/c mice with MOPC-104E myeloma protein induced idiotype-specific enhancing B cells that acted on anti-dextran antibody producing B cells. The enhancing cells have the surface phenotype of B cells. With the use of several H-2 or Igh congenic mice, it was found that the cooperation among B cells was controlled by both the major histocompatibility complex (MHC) and Igh. The capability to generate enhancing B cell activity was analyzed by using tetraparental bone marrow chimeras. (C57BL/6 X BALB/c)F1 mice, for example, were lethally irradiated and were reconstituted with C57BL/6 and BALB/c bone marrow cells. Nine to 12 wk after the reconstitution, the chimeras were immunized with the myeloma protein and were tested for their enhancing B cell activity. After the removal of C57BL/6 origin cells by treatment with anti-H-2b + complement, residual cells exhibited enhancing B cell activity on BALB.B, as well as BALB/c antidextran antibody response. This indicates that the generation of H-2-restricted, idiotype-specific enhancing B cell activity differentiated adaptively so as to recognize foreign MHC as self under chimeric conditions. On the other hand, splenic B cells treated with anti-H-2d + complement did not enhance the responses of BALB/c or BALB.B. Even in a chimeric environment, the B cells of C57BL/6 origin could not obtain the ability to generate enhancing B cell activity upon immunization of the idiotype. The results described here, taken in conjunction with our previous studies, suggest that the Ig heavy chain gene(s) predominantly control the Igh restriction properties of enhancing B cells, and the capability of MHC recognition by B cells is selected under chimeric conditions.

Yamamoto, H.; Bitoh, S.; Fujimoto, S.

1987-01-15T23:59:59.000Z

408

Human Reliability Analysis for Digital Human-Machine Interfaces  

SciTech Connect (OSTI)

This paper addresses the fact that existing human reliability analysis (HRA) methods do not provide guidance on digital human-machine interfaces (HMIs). Digital HMIs are becoming ubiquitous in nuclear power operations, whether through control room modernization or new-build control rooms. Legacy analog technologies like instrumentation and control (I&C) systems are costly to support, and vendors no longer develop or support analog technology, which is considered technologically obsolete. Yet, despite the inevitability of digital HMI, no current HRA method provides guidance on how to treat human reliability considerations for digital technologies.

Ronald L. Boring

2014-06-01T23:59:59.000Z

409

06241 Abstracts Collection Human Motion -Understanding, Modeling,  

E-Print Network [OSTI]

06241 Abstracts Collection Human Motion - Understanding, Modeling, Capture and Animation. 13th Summary Human Motion - Understanding, Modeling, Capture and Animation. 13th Workshop Reinhard Klette 06241 Human Motion - Understanding, Modeling, Capture and Animation. 13th Workshop "Theoretical

410

Guest editorial: Special issue on human computing  

E-Print Network [OSTI]

The seven articles in this special issue focus on human computing. Most focus on two challenging issues in human computing, namely, machine analysis of human behavior in group interactions and context-sensitive modeling.

Pantic, Maja

411

Human genome. 1993 Program report  

SciTech Connect (OSTI)

The purpose of this report is to update the Human Genome 1991-92 Program Report and provide new information on the DOE genome program to researchers, program managers, other government agencies, and the interested public. This FY 1993 supplement includes abstracts of 60 new or renewed projects and listings of 112 continuing and 28 completed projects. These two reports, taken together, present the most complete published view of the DOE Human Genome Program through FY 1993. Research is progressing rapidly toward 15-year goals of mapping and sequencing the DNA of each of the 24 different human chromosomes.

Not Available

1994-03-01T23:59:59.000Z

412

Flesh yours, bones mine : the making of the biomedical subject in Turkey  

E-Print Network [OSTI]

With the emergence of biomedical technologies, human body parts from living or dead donors have become commodities in the international networks of trade. This dissertation tries to understand religious, political and ...

Sanal, Aslihan

2005-01-01T23:59:59.000Z

413

Application of in vitro erythropoiesis from bone marrow derived progenitors to detect and study genotoxicity  

E-Print Network [OSTI]

Assays that predict toxicity are an essential part of drug development and there is a demand for efficient models to better predict human responses. The in vivo micronucleus (MN) assay is a robust toxicity test that assesses ...

Shuga, Joseph F. (Joseph Francis)

2007-01-01T23:59:59.000Z

414

Mutations in Bone Marrow-Derived Stromal Stem Cells Unmask Latent Malignancy  

E-Print Network [OSTI]

Neoplastic epithelia may remain dormant and clinically unapparent in human patients for decades. Multiple risk factors including mutations in tumor cells or the stromal cells may affect the switch from dormancy to malignancy. ...

Houghton, JeanMarie

415

Corporate Human Resources Information Services (CHIRS) PIA, Office...  

Broader source: Energy.gov (indexed) [DOE]

Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol...

416

The Politics of Human Rights in Argentina  

E-Print Network [OSTI]

Valente,  Marcela.  “Argentina’s  Biggest  Human  Rights  Motor  is  Linked  to  Argentina’s  ‘Dirty  War’”.   New  fortune  of  my  heart.   Argentina's  1985  human  rights  

Brysk, Alison

2013-01-01T23:59:59.000Z

417

Scientists Help Define the Healthy Human Microbiome  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Scientists Help Define the Healthy Human Microbiome Scientists Help Define the Healthy Human Microbiome Computing, bioinformatics, and microbial ecology resources play key role in...

418

HUMAN RESOURCES SIMON FRASER UNIVERSITY  

E-Print Network [OSTI]

) by coordinating budget submissions, estimating and preparing cost projections, liaising with PurchasingHUMAN RESOURCES SIMON FRASER UNIVERSITY ADMINISTRATIVE & PROFESSIONAL JOB DESCRIPTION Position of the position in one or two sentences. Manages the Department's operating, capital, temporary instruction

419

HUMAN RESOURCES SIMON FRASER UNIVERSITY  

E-Print Network [OSTI]

funding priorities, budget consideration, application requirements, University policies and proceduresHUMAN RESOURCES SIMON FRASER UNIVERSITY ADMINISTRATIVE & PROFESSIONAL JOB DESCRIPTION Position to Canadian and international funding agencies. The incumbent will assist with the writing and reviewing

420

HUMAN RESOURCES SIMON FRASER UNIVERSITY  

E-Print Network [OSTI]

. The position is responsible for developing test scenarios, responding to system problems by investigating regarding the design of testing scenarios and scripts and how to evaluate outcomes. Makes decisions1 HUMAN RESOURCES SIMON FRASER UNIVERSITY TEMPORARY ADMINISTRATIVE & PROFESSIONAL STAFF POSITION

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

ORISE: Human Subjects Research Database  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Human Subjects Research Database Section 10, Part 745 of the Code of Federal Regulations and U.S. Department of Energy (DOE) Orders 443.1 and 481.1 require the maintenance of...

422

Robot manipulation in human environments  

E-Print Network [OSTI]

Human environments present special challenges for robot manipulation. They are often dynamic, difficult to predict, and beyond the control of a robot engineer. Fortunately, many characteristics of these settings can be ...

Edsinger, Aaron Ladd, 1972-

2007-01-01T23:59:59.000Z

423

Robot Manipulation in Human Environments  

E-Print Network [OSTI]

Human environments present special challenges for robot manipulation. They are often dynamic, difficult to predict, and beyond the control of a robot engineer. Fortunately, many characteristics of these settings can be ...

Edsinger, Aaron

2007-01-16T23:59:59.000Z

424

Contractor Human Resource Management Programs  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09

1996-09-30T23:59:59.000Z

425

Contractor Human Resource Management Programs  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09.

1996-09-30T23:59:59.000Z

426

Coördinating human-robot communication  

E-Print Network [OSTI]

As robots begin to emerge from the cloisters of industrial and military applications and enter the realms of coöperative partners for people, one of the most important facets of human-robot interaction (HRI) will be ...

Brööks, Andrëw G. (Brööks Zoz)

2007-01-01T23:59:59.000Z

427

Director Human Resources Assoc Director  

E-Print Network [OSTI]

Director ­ Human Resources Assoc Director Workforce Planning & Organisational Change Director) - Organisational change - Workforce planning - Grievance & performance mgt support - Performance management line and not a formal Branch ** Includes Classifications ANU Search Workforce Planning* Remunerations

Botea, Adi

428

Unravelling daily human mobility motifs  

E-Print Network [OSTI]

Human mobility is differentiated by time scales. While the mechanism for long time scales has been studied, the underlying mechanism on the daily scale is still unrevealed. Here, we uncover the mechanism responsible for ...

Schneider, Christian M.

429

Reservations to human rights treaties   

E-Print Network [OSTI]

This thesis examines the default application of the 1969 Vienna Convention on the Law of Treaties reservation rules to reservations to human rights treaties. The contemporary practice of formulating reservations allows ...

McCall-Smith, Kasey Lowe

2012-06-26T23:59:59.000Z

430

Human Factors of Reporting Systems  

E-Print Network [OSTI]

Johnson,C.W. P. Carayon (ed.), A Handbook of Human Factors and Ergonomics in Healthcare and Patient Safety, Lawrence Erlbaum, London, UK. pp 715-750 Lawrence Erlbaum Associates

Johnson, C.W.

431

Human Genome Education Program  

SciTech Connect (OSTI)

The funds from the DOE Human Genome Program, for the project period 2/1/96 through 1/31/98, have provided major support for the curriculum development and field testing efforts for two high school level instructional units: Unit 1, ''Exploring Genetic Conditions: Genes, Culture and Choices''; and Unit 2, ''DNA Snapshots: Peaking at Your DNA''. In the original proposal, they requested DOE support for the partial salary and benefits of a Field Test Coordinator position to: (1) complete the field testing and revision of two high school curriculum units, and (2) initiate the education of teachers using these units. During the project period of this two-year DOE grant, a part-time Field-Test Coordinator was hired (Ms. Geraldine Horsma) and significant progress has been made in both of the original proposal objectives. Field testing for Unit 1 has occurred in over 12 schools (local and non-local sites with diverse student populations). Field testing for Unit 2 has occurred in over 15 schools (local and non-local sites) and will continue in 12-15 schools during the 96-97 school year. For both curricula, field-test sites and site teachers were selected for their interest in genetics education and in hands-on science education. Many of the site teachers had no previous experience with HGEP or the unit under development. Both of these first-year biology curriculum units, which contain genetics, biotechnology, societal, ethical and cultural issues related to HGP, are being implemented in many local and non-local schools (SF Bay Area, Southern California, Nebraska, Hawaii, and Texas) and in programs for teachers. These units will reach over 10,000 students in the SF Bay Area and continues to receive support from local corporate and private philanthropic organizations. Although HGEP unit development is nearing completion for both units, data is still being gathered and analyzed on unit effectiveness and student learning. The final field testing result from this analysis will contribute to the final revisions of each unit during the second-year of this grant.

Richard Myers; Lane Conn

2000-05-01T23:59:59.000Z

432

Protection of Human Research Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in Title 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects, 45 CFR Part 46, and the Secretarial Policy Memorandum on Military or Intelligence-Related Human Subject Research, December 9, 2009. Cancels DOE O 443.1A and DOE P 443.1A.

2009-12-09T23:59:59.000Z

433

Trabecular Microarchitecture, Endplate Failure, and the Biomechanics of Human Vertebral Fractures  

E-Print Network [OSTI]

The Worldwide Problem of Osteoporosis - Insights Afforded byN. The diagnosis of osteoporosis. J Bone Miner Res 1994;9:of fracture in women with osteoporosis? Bone 2000;27: 1-3.

Fields, Aaron Joseph

2010-01-01T23:59:59.000Z

434

Please send suggestions for improvement to John Webster, webster@engr.wisc.edu, 608-263-1574 9.12 BONES AND JOINTS  

E-Print Network [OSTI]

, like a chunk of rubber, and can even be bent into a loop. When collagen is removed from the bone by calcium varies rapidly with energy in this range of energies; the relatively large beam contains much

Lakes, Roderic

435

Dissociable Neural Systems Supporting Knowledge about Human Character Appearance in Ourselves and Others  

E-Print Network [OSTI]

Functional neuroimaging has identified a neural system comprised of posterior cingulate (pCC) and medial prefrontal (mPFC) cortices that appears to mediate self-referential thought. It is unclear whether the two components ...

Gabrieli, John D. E.

436

INSECT TRACE FOSSILS ON DINOSAUR BONES FROM THE UPPER JURASSIC MORRISON FORMATION, NORTHEASTERN WYOMING, AND THEIR USE IN VERTEBRATE TAPHONOMY  

E-Print Network [OSTI]

carcasses by their inability to excavate tunnels in sediment. In this thesis I apply the principles of forensic entomology to study the taphonomic history of sauropod skeletons at the KU-WY-121 quarry in the Upper Jurassic Morrison Formation... and Martin, 2002; West and Hasiotis, 2007). Fossil bone modification by arthropods has been reported from the Late Jurassic, Cretaceous, Paleogene, and Neogene (Table 2). Traces include circular to oval pits, scratches, tunnels, notches, and channels...

Bader, Kenneth Stephen

2008-08-21T23:59:59.000Z

437

A Signal-Inducing Bone Cement for Magnetic Resonance Imaging-Guided Spinal Surgery Based on Hydroxyapatite and Polymethylmethacrylate  

SciTech Connect (OSTI)

The aim of this study was to develop a signal-inducing bone cement for magnetic resonance imaging (MRI)-guided cementoplasty of the spine. This MRI cement would allow precise and controlled injection of cement into pathologic lesions of the bone. We mixed conventional polymethylmethacrylate bone cement (PMMA; 5 ml methylmethacrylate and 12 g polymethylmethacrylate) with hydroxyapatite (HA) bone substitute (2-4 ml) and a gadolinium-based contrast agent (CA; 0-60 {mu}l). The contrast-to-noise ratio (CNR) of different CA doses was measured in an open 1.0-Tesla scanner for fast T1W Turbo-Spin-Echo (TSE) and T1W TSE pulse sequences to determine the highest signal. We simulated MRI-guided cementoplasty in cadaveric spines. Compressive strength of the cements was tested. The highest CNR was (1) 87.3 (SD 2.9) in fast T1W TSE for cements with 4 {mu}l CA/ml HA (4 ml) and (2) 60.8 (SD 2.4) in T1W TSE for cements with 1 {mu}l CA/ml HA (4 ml). MRI-guided cementoplasty in cadaveric spine was feasible. Compressive strength decreased with increasing amounts of HA from 46.7 MPa (2 ml HA) to 28.0 MPa (4 ml HA). An MRI-compatible cement based on PMMA, HA, and CA is feasible and clearly visible on MRI images. MRI-guided spinal cementoplasty using this cement would permit direct visualization of the cement, the pathologic process, and the anatomical surroundings.

Wichlas, Florian, E-mail: florian.wichlas@charite.de; Seebauer, Christian J.; Schilling, Rene [University Charite, Center for Musculoskeletal Surgery (Germany); Rump, Jens [University Charite, Department of Radiology (Germany); Chopra, Sascha S. [University Charite, Center for Musculoskeletal Surgery (Germany); Walter, Thula; Teichgraeber, Ulf K. M. [University Charite, Department of Radiology (Germany); Bail, Hermann J. [University Charite, Center for Musculoskeletal Surgery (Germany)

2012-06-15T23:59:59.000Z

438

Booster irradiation to the spleen following total body irradiation. A new immunosuppressive approach for allogeneic bone marrow transplantation  

SciTech Connect (OSTI)

Graft rejection presents a major obstacle for transplantation of T cell-depleted bone marrow in HLA-mismatched patients. In a primate model, after conditioning exactly as for leukemia patients, it was shown that over 99% of the residual host clonable T cells are concentrated in the spleen on day 5 after completion of cytoreduction. We have now corroborated these findings in a mouse model. After 9-Gy total body irradiation (TBI), the total number of Thy-1.2+ cells in the spleen reaches a peak between days 3 and 4 after TBI. The T cell population is composed of both L3T4 (helper) and Lyt-2 (suppressor) T cells, the former being the major subpopulation. Specific booster irradiation to the spleen (5 Gy twice) on days 2 and 4 after TBI greatly enhances production of donor-type chimera after transplantation of T cell-depleted allogeneic bone marrow. Similar enhancement can be achieved by splenectomy on day 3 or 4 after TBI but not if splenectomy is performed 1 day before TBI or 1 day after TBI, strengthening the hypothesis that, after lethal TBI in mice, the remaining host T cells migrate from the periphery to the spleen. These results suggest that a delayed booster irradiation to the spleen may be beneficial as an additional immunosuppressive agent in the conditioning of leukemia patients, in order to reduce the incidence of bone marrow allograft rejection.

Lapidot, T.; Singer, T.S.; Salomon, O.; Terenzi, A.; Schwartz, E.; Reisner, Y.

1988-10-15T23:59:59.000Z

439

Low-Income Weatherization: The Human Dimension  

Broader source: Energy.gov [DOE]

This presentation focuses on how the human dimension saves energy within low-income weatherization programs.

440

Haptic Human Interfaces for Robotic Telemanipulation  

E-Print Network [OSTI]

While discussing human perception mechanisms , Sekuler and Balke [1] eloquently stated that ... whether of regard. Human haptic perception is the result of a complex investigatory dexterous manipulation act-level perception and task planning abilities of a human operator equipped with adequate human interfaces [6

Payeur, Pierre

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to obtain the most current and comprehensive results.


441

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

62 College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES of Architecture, Arts and Humanities offers one-of-a- kind opportunities for interdisciplinary exploration, but the enduring questions. The College of Architecture, Arts and Humanities is organized into three schools

Stuart, Steven J.

442

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

63 College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES of Architecture, Arts and Humanities offers one-of-a- kind opportunities for interdisciplinary exploration, but the enduring questions. The College of Architecture, Arts and Humanities is organized into three schools

Stuart, Steven J.

443

The SACADA database for human reliability and human performance  

SciTech Connect (OSTI)

Lack of appropriate and sufficient human performance data has been identified as a key factor affecting human reliability analysis (HRA) quality especially in the estimation of human error probability (HEP). The Scenario Authoring, Characterization, and Debriefing Application (SACADA) database was developed by the U.S. Nuclear Regulatory Commission (NRC) to address this data need. An agreement between NRC and the South Texas Project Nuclear Operating Company (STPNOC) was established to support the SACADA development with aims to make the SACADA tool suitable for implementation in the nuclear power plants' operator training program to collect operator performance information. The collected data would support the STPNOC's operator training program and be shared with the NRC for improving HRA quality. This paper discusses the SACADA data taxonomy, the theoretical foundation, the prospective data to be generated from the SACADA raw data to inform human reliability and human performance, and the considerations on the use of simulator data for HRA. Each SACADA data point consists of two information segments: context and performance results. Context is a characterization of the performance challenges to task success. The performance results are the results of performing the task. The data taxonomy uses a macrocognitive functions model for the framework. At a high level, information is classified according to the macrocognitive functions of detecting the plant abnormality, understanding the abnormality, deciding the response plan, executing the response plan, and team related aspects (i.e., communication, teamwork, and supervision). The data are expected to be useful for analyzing the relations between context, error modes and error causes in human performance.

Y. James Chang; Dennis Bley; Lawrence Criscione; Barry Kirwan; Ali Mosleh; Todd Madary; Rodney Nowell; Robert Richards; Emilie M. Roth; Scott Sieben; Antonios Zoulis

2014-05-01T23:59:59.000Z

444

ATHENA, the Desktop Human "Body"  

SciTech Connect (OSTI)

Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

Iyer, Rashi; Harris, Jennifer

2014-09-29T23:59:59.000Z

445

ATHENA, the Desktop Human "Body"  

ScienceCinema (OSTI)

Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

Iyer, Rashi; Harris, Jennifer

2015-01-05T23:59:59.000Z

446

Bone marrow-derived mesenchymal stem cells enhance angiogenesis via their ?6?1 integrin receptor  

SciTech Connect (OSTI)

Bone marrow-derived mesenchymal stem cells (BMSCs) facilitate the angiogenic response of endothelial cells (ECs) within three-dimensional (3D) matrices in vivo and in engineered tissues in vitro in part through paracrine mediators and by acting as stabilizing pericytes. However, the molecular interactions between BMSCs and nascent tubules during the process of angiogenesis are not fully understood. In this study, we have used a tractable 3D co-culture model to explore the functional role of the ?6?1 integrin adhesion receptor on BMSCs in sprouting angiogenesis. We report that knockdown of the ?6 integrin subunit in BMSCs significantly reduces capillary sprouting, and causes their failure to associate with the nascent vessels. Furthermore, we demonstrate that the BMSCs with attenuated ?6 integrin proliferate at a significantly lower rate relative to either control cells expressing non-targeting shRNA or wild type BMSCs; however, despite adding more cells to compensate for this deficit in proliferation, deficient sprouting persists. Collectively, our findings demonstrate that the ?6 integrin subunit in BMSCs is important for their ability to stimulate vessel morphogenesis. This conclusion may have important implications in the optimization of cell-based strategies to promote angiogenesis. Highlights: • BMSCs stimulate angiogenesis, but the mechanisms remain unclear. • We silenced the expression of the ?6 integrin subunit in BMSCs. • Silencing this receptor subunit significantly inhibited angiogenic sprouting. • Knocking down ?6 integrin affected laminin and ?SMA expression. • Silencing ?6 integrin expression also reduced BMSC proliferation.

Carrion, Bita; Kong, Yen P. [Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 (United States); Kaigler, Darnell [Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 (United States); Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI 48109 (United States); Putnam, Andrew J., E-mail: putnam@umich.edu [Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 (United States)

2013-11-15T23:59:59.000Z

447

Pyrolysis and gasification of meat-and-bone-meal: Energy balance and GHG accounting  

SciTech Connect (OSTI)

Highlights: • GHG savings are in the order of 600–1000 kg CO{sub 2}-eq. per Mg of MBM treated. • Energy recovery differed in terms of energy products and efficiencies. • The results were largely determined by use of the products for energy purposes. - Abstract: Meat-and-bone-meal (MBM) produced from animal waste has become an increasingly important residual fraction needing management. As biodegradable waste is routed away from landfills, thermo-chemical treatments of MBM are considered promising solution for the future. Pyrolysis and gasification of MBM were assessed based on data from three experimental lab and pilot-scale plants. Energy balances were established for the three technologies, providing different outcomes for energy recovery: bio-oil was the main product for the pyrolysis system, while syngas and a solid fraction of biochar were the main products in the gasification system. These products can be used – eventually after upgrading – for energy production, thereby offsetting energy production elsewhere in the system. Greenhouse gases (GHG) accounting of the technologies showed that all three options provided overall GHG savings in the order of 600–1000 kg CO{sub 2}-eq. per Mg of MBM treated, mainly as a consequence of avoided fossil fuel consumption in the energy sector. Local conditions influencing the environmental performance of the three systems were identified, together with critical factors to be considered during decision-making regarding MBM management.

Cascarosa, Esther [Thermochemical Processes Group, Aragón Institute for Engineering Research (I3A), Universidad de Zaragoza (Spain); Boldrin, Alessio, E-mail: aleb@env.dtu.dk [Department of Environmental Engineering. Technical University of Denmark, Kongens Lyngby (Denmark); Astrup, Thomas [Department of Environmental Engineering. Technical University of Denmark, Kongens Lyngby (Denmark)

2013-11-15T23:59:59.000Z

448

Innovative Composites Through Reinforcement Morphology Design - a Bone-Shaped-Short-Fiber Composite  

SciTech Connect (OSTI)

This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objective of this project is to improve the strength and toughness of conventional short-fiber composites by using innovative bone-shaped-short (BSS) fibers as reinforcement. We fabricated a model polyethylene BSS fiber-reinforced polyester-matrix composite to prove that fiber morphology, instead of interfacial strength, solves the problem. Experimental tensile and fracture toughness test results show that BSS fibers can bridge matrix cracks more effectively, and consume many times more energy when pulled out, than conventional-straight-short (CSS) fibers. This leads to both higher strength and fracture toughness for the BSS-fiber composites. A computational model was developed to simulate crack propagation in both BSS- and CSS-fiber composites, accounting for stress concentrations, interface debonding, and fiber pullout. Model predictions were validated by experimental results and will be useful in optimizing BSS-fiber morphology and other material system parameters.

Zhu, Y.T.; Valdez, J.A.; Beyerlain, I.J.; Stout, M.G.; Zhou, S.; Shi, N.; Lowe, T.C.

1999-06-29T23:59:59.000Z

449

Quantum Physics and Human Language  

E-Print Network [OSTI]

Human languages employ constructions that tacitly assume specific properties of the limited range of phenomena they evolved to describe. These assumed properties are true features of that limited context, but may not be general or precise properties of all the physical situations allowed by fundamental physics. In brief, human languages contain `excess baggage' that must be qualified, discarded, or otherwise reformed to give a clear account in the context of fundamental physics of even the everyday phenomena that the languages evolved to describe. The surest route to clarity is to express the constructions of human languages in the language of fundamental physical theory, not the other way around. These ideas are illustrated by an analysis of the verb `to happen' and the word `reality' in special relativity and the modern quantum mechanics of closed systems.

James B. Hartle

2006-12-19T23:59:59.000Z

450

WILD PIG ATTACKS ON HUMANS  

SciTech Connect (OSTI)

Attacks on humans by wild pigs (Sus scrofa) have been documented since ancient times. However, studies characterizing these incidents are lacking. In an effort to better understand this phenomenon, information was collected from 412 wild pig attacks on humans. Similar to studies of large predator attacks on humans, data came from a variety of sources. The various attacks compiled occurred in seven zoogeographic realms. Most attacks occurred within the species native range, and specifically in rural areas. The occurrence was highest during the winter months and daylight hours. Most happened under non-hunting circumstances and appeared to be unprovoked. Wounded animals were the chief cause of these attacks in hunting situations. The animals involved were typically solitary, male and large in size. The fate of the wild pigs involved in these attacks varied depending upon the circumstances, however, most escaped uninjured. Most human victims were adult males traveling on foot and alone. The most frequent outcome for these victims was physical contact/mauling. The severity of resulting injuries ranged from minor to fatal. Most of the mauled victims had injuries to only one part of their bodies, with legs/feet being the most frequent body part injured. Injuries were primarily in the form of lacerations and punctures. Fatalities were typically due to blood loss. In some cases, serious infections or toxemia resulted from the injuries. Other species (i.e., pets and livestock) were also accompanying some of the humans during these attacks. The fates of these animals varied from escaping uninjured to being killed. Frequency data on both non-hunting and hunting incidents of wild pig attacks on humans at the Savannah River Site, South Carolina, showed quantitatively that such incidents are rare.

Mayer, J.

2013-04-12T23:59:59.000Z

451

Mesenchymal Stem Cell Transplantation to Promote Bone Healing Chan Gao,1,2  

E-Print Network [OSTI]

in humans. The objective of the current study was to deter- mine if transplantation of mesenchymal stromal performed on reasonably young, active recipients in the past two decades have used implants with porous individuals as a result of treatment for cancer or graft versus host disease.5 The majority of joint

Buschmann, Michael

452

Cognitive Engineering Automation and Human  

E-Print Network [OSTI]

· Home automation · Robotics · Unmanned vehicles (UAVs and UGVs) · Drug design/Molecular geneticsCognitive Engineering PSYC 530 Automation and Human Performance Raja Parasuraman #12;Overview Automation-Related Accidents Levels and Stages of Automation Information Acquisition and Analysis Decision

Parasuraman, Raja

453

NCSU Human Resources Training & Organizational  

E-Print Network [OSTI]

2011 NCSU Human Resources Training & Organizational Development Spring & Summer 2011 Learning to Training & Organizational Development's new eLearning Training Catalog. This catalog serves as a central information regarding: Participating Units and Who To Contact Certificate Programs Courses and Sessions eLearning

454

Human retroviruses and AIDS 1994  

SciTech Connect (OSTI)

This compendium, including accompanying floppy diskettes, is the result of an effort to compile and rapidly publish all relevant molecular data concerning the human immunodeficiency viruses (HIV) and related retroviruses. The scope of the compendium and database is best summarized by the five parts it comprises: (I) Nucleic Acid Alignments and Sequences; (II) Amino Acid Alignments; (III) Analysis; (IV) Related Sequences; (V) Database communications.

Myers, G.; Korber, B. [Los Alamos National Lab., NM (United States); Wain-Hobson, S.; Jeang, Kuan-Teh; Henderson, L.E.; Pavlakis, G.N. [eds.

1995-01-01T23:59:59.000Z

455

Biodiversity in Human-Impacted  

E-Print Network [OSTI]

1 #12;1 Biodiversity in Human-Impacted Landscapes Biodiversidad en Paisajes Intervenidos Volumen-1 complex and dynamic. Traditionally, efforts to protect biodiversity and address environmental problems abilities of policy makers and on-the-ground practitioners is essential to biodiversity conservation

Haller, Gary L.

456

EMERGENCY HIRE GUIDELINES HUMAN RESOURCES  

E-Print Network [OSTI]

EMERGENCY HIRE GUIDELINES HUMAN RESOURCES Workforce Planning · One Washington Square · San José, Ca: Workforce Planning; Sr. Workforce Planning Analyst DATE: May 2, 2008 I. PURPOSE / DESCRIPTION The Emergency. B. The Workforce Planning Analyst will work with the hiring manager/HR contact to identify and hire

Su, Xiao

457

COLLEGE OF ENGINEERING Human Health  

E-Print Network [OSTI]

the exciting stories about how our faculty, students, and alumni are engineering solutions to health careCOLLEGE OF ENGINEERING Human Health #12;Welcome to our Health issue ­ Please take the time to read to tackle large worldwide health problems. A few years ago, the College of Engineering made a strategic

458

Mechanosensitivity of human osteosarcoma cells and phospholipase C {beta}2 expression  

SciTech Connect (OSTI)

Bone adapts to mechanical load by osteosynthesis, suggesting that osteoblasts might respond to mechanical stimuli. We therefore investigated cell proliferation and phospholipase C (PLC) expression in osteoblasts. One Hertz uniaxial stretching at 4000 {mu}strains significantly increased the proliferation rates of human osteoblast-like osteosarcoma cell line MG-63 and primary human osteoblasts. However, U-2/OS, SaOS-2, OST, and MNNG/HOS cells showed no significant changes in proliferation rate. We investigated the expression pattern of different isoforms of PLC in these cell lines. We were able to detect PLC {beta}1, {beta}3, {gamma}1, {gamma}2, and {delta}1 in all cells, but PLC {beta}2 was only detectable in the mechanosensitive cells. We therefore investigated the possible role of PLC {beta}2 in mechanotransduction. Inducible antisense expression for 24 h inhibited the translation of PLC {beta}1 in U-2/OS cells by 35% and PLC {beta}2 in MG-63 by 29%. Fluid shear flow experiments with MG-63 lacking PLC {beta}2 revealed a significantly higher level of cells losing attachment to coverslips and a significantly lower number of cells increasing intracellular free calcium.

Hoberg, M. [Department of Orthopaedics, University of Tuebingen (Germany)]. E-mail: Maik.Hoberg@med.uni-tuebingen.de; Gratz, H.-H. [Experimental Orthopaedics and Biomechanics, Phillips-University of Marburg (Germany); Noll, M. [Experimental Orthopaedics and Biomechanics, Phillips-University of Marburg (Germany); Jones, D.B. [Experimental Orthopaedics and Biomechanics, Phillips-University of Marburg (Germany)

2005-07-22T23:59:59.000Z

459

Efficient natural defense mechanisms against Listeria monocytogenes in T and B cell-deficient allogeneic bone marrow radiation chimeras. Preactivated macrophages are the main effector cells in an early phase after bone marrow transfer  

SciTech Connect (OSTI)

Radiation chimeras in the early phase after bone marrow transplantation are a good model to study the efficiency of the body's nonspecific defense system represented by macrophages (M phi), polymorphonuclear cells (PMN), and NK cells. These cell types are present in large numbers in spleen and liver at that time, whereas the specific immune system represented by T and B cells is functionally deficient. We previously reported enhanced activities in vitro of M phi (and PMN) from recipient animals in an early phase after allogeneic bone marrow transfer. We here demonstrate that these activities result in enhanced spontaneous resistance against Listeria monocytogenes in vivo: CFU of L. monocytogenes in spleen and liver 48 h after infection were about 1 or 2 to 4 log steps less than in untreated control mice of donor or host haplotype. This enhanced resistance decreased over the 4-mo period after marrow transfer. Preactivated M phi were identified as the most important effector cells. Isolated from spleen and peritoneal cavity, they performed enhanced killing of phagocytosed Listeria. Such preactivated M phi occurred in recipient animals after transfer of allogeneic but not of syngeneic bone marrow. The precise mechanism of M phi activation in the allogeneic radiation chimera in the complete absence of any detectable T cell function is not clear at present. However, these preactivated M phi display an important protective effect against L. monocytogenes: chimeras could eliminate Listeria without acquisition of positive delayed-type sensitivity when infected with 10(3) bacteria. An inoculum of 5 . 10(3) L. monocytogenes resulted either in prolonged survival compared with normal mice of the recipient haplotype or in definitive survival accompanied by a positive delayed-type sensitivity.

Roesler, J.; Groettrup, E.B.; Baccarini, M.; Lohmann-Mattes, M.L. (Fraunhofer-Institut ITA, Hannover (Germany, F.R.))

1989-09-01T23:59:59.000Z

460

Cyclophilin A (CypA) is associated with the inflammatory infiltration and alveolar bone destruction in an experimental periodontitis  

SciTech Connect (OSTI)

Background and objective: CypA is able to regulate inflammatory responses and MMPs production via interaction with its cell surface receptor, EMMPRIN. This study aimed to address the possible association of CypA with pathological inflammation and destruction of periodontal tissues, and whether CypA-EMMPRIN interaction exists in periodontitis. Materials and methods: Experimental periodontitis was induced by ligation according to our previous method. Histological and radiographic examinations were performed. Western blot was used to detect CypA and EMMPRIN expressions in gingival tissues. Immunohistochemistry was applied for CypA, EMMPRIN, MMP-1, MMP-2, MMP-9, as well as cell markers of macrophage, lymphocyte and neutrophil. CypA expression, alveolar bone loss, and inflammatory infiltrations were quantified followed by correlation analyses. Results: Western blot revealed that CypA and EMMRPIN expressions were dramatically elevated in inflamed gingival tissues (ligature group) as compared to healthy gingival tissues (control group). The enhanced CypA and EMMPRIN expressions were highly consistent in cell localization on seriate sections. They were permanently co-localized in infiltrating macrophages and lymphocytes, as well as osteoclasts and osteoblasts in interradicular bone, but rarely expressed by infiltrating neutrophils. MMP-1, MMP-2, and MMP-9 expressions were also sharply increased in inflamed gingiva. MMP-2 and MMP-9 were mainly over-expressed by macrophages, while MMP-1 was over-produced by fibroblasts and infiltrating cells. The number of CypA-positive cells was strongly correlated with the ACJ-AC distance (r = 0.839, p = 0.000), the number of macrophages (r = 0.972, p = 0.000), and the number of lymphocytes (r = 0.951, p = 0.000). Conclusion: CypA is associated with the inflammatory infiltration and alveolar bone destruction of periodontitis. CypA-EMMPRIN interaction may exist in these pathological processes.

Liu, Lihua [Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Hongshan District, Wuhan 430079 (China)] [Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Hongshan District, Wuhan 430079 (China); Li, Chengzhang, E-mail: l56cz@hotmail.com [Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Hongshan District, Wuhan 430079 (China) [Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Hongshan District, Wuhan 430079 (China); Department of Periodontology, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Hongshan District, Wuhan 430079 (China); Cai, Cia [Department of Periodontology, School and Hospital of Stomatology, Zhejiang University, 395 Yan An Road, Hangzhou 310006 (China)] [Department of Periodontology, School and Hospital of Stomatology, Zhejiang University, 395 Yan An Road, Hangzhou 310006 (China); Xiang, Junbo [Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Hongshan District, Wuhan 430079 (China)] [Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Hongshan District, Wuhan 430079 (China); Cao, Zhengguo, E-mail: jery7677@hotmail.com [Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Hongshan District, Wuhan 430079 (China) [Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Hongshan District, Wuhan 430079 (China); Department of Periodontology, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Hongshan District, Wuhan 430079 (China)

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Propeller based human powered swimming device  

E-Print Network [OSTI]

Currently the only human powered swimming device widely sold on the market are swim flippers. However, flippers are not efficient for the human body, and there is a potential to increase the speed while swimming with a ...

Bunker, Kristine (Kristine Alina)

2014-01-01T23:59:59.000Z

462

GT Human Resources PERSONAL DATA FORM  

E-Print Network [OSTI]

GT Human Resources PERSONAL DATA FORM Page 1 Updated: 0//201 Student Employee? Yes No Print clearly.: _________________________________ Job Title: Email: _________________________________ #12;GT Human Resources PERSONAL DATA FORM Page 2 using black or blue ink. Personal Information Name

Garmestani, Hamid

463

GT Human Resources PERSONAL DATA FORM  

E-Print Network [OSTI]

GT Human Resources PERSONAL DATA FORM Page 1 Updated: 05/01/2014 Student Employee? Yes No Print.: _________________________________ Job Title: _________________________________ #12;GT Human Resources PERSONAL DATA FORM Page 2 Updated clearly using black or blue ink. Personal Information Name

Jacobs, Laurence J.

464

Human Biology Program Brown Bag Series  

E-Print Network [OSTI]

Human Biology Program Brown Bag Series Fall 2012 12:001:00 pm Morrison Hall 103 SeptemberVisser Department of Biology & Human Biology Prog. "Good Behavior, Bad Behavior: Insights From the Microbial

Indiana University

465

Cost estimation of human systems integration  

E-Print Network [OSTI]

Human Systems Integration (HSI) is the interdisciplinary technical and management processes for integrating human considerations within and across all system elements. The goal of this research is to develop a better ...

Liu, Kevin K. (Kevin Kaitan), 1986-

2010-01-01T23:59:59.000Z

466

Video looping of human cyclic motion  

E-Print Network [OSTI]

In this thesis, a system called Video Looping is developed to analyze human cyclic motions. Video Looping allows users to extract human cyclic motion from a given video sequence. This system analyzes similarities from a large amount of live footage...

Choi, Hye Mee

2004-09-30T23:59:59.000Z

467

Human Resources Organizational Development and Training  

E-Print Network [OSTI]

Human Resources Organizational Development and Training November 2009 Development Guide for Tufts Organizational Competencies Copyright © 2009 Tufts University #12;Human Resources Organizational Development Resources Organizational Development and Training 3 INTRODUCTION TO THE GUIDE November 2009 Dear Tufts

Dennett, Daniel

468

In Vitro Perfused Human Capillary Networks  

E-Print Network [OSTI]

during vessel network formation, micro- spheres traversedof a living network of dynamic human capillaries in a micro-

Moya, Monica L.; Hsu, Yu-Hsiang; Lee, Abraham P.; Hughes, Christopher C.W.; George, Steven C.

2013-01-01T23:59:59.000Z

469

Guessing human-chosen secrets  

E-Print Network [OSTI]

number of third parties seeking to authenticate users [121, 244]. Reliable data on damages caused by weak human-chosen secrets is hard to come by [141], but a recent study of corporate data breaches commissioned by Verizon [12] suggested that nearly a... on Financial Cryptography and Data Security. Springer-Verlag, 2012 Some data on personal knowledge questions analysed in §7 was published in collaboration with Mike Just and Greg Matthews, who assisted in gathering government census records from around...

Bonneau, Joseph

2012-06-12T23:59:59.000Z

470

Contractor Human Resource Management Programs  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This directive establishes DOE responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. DOE O 350.1 Chg 5, dated 9-30-2014, cancels Chapters I-III of DOE O 350.1 Chg 4

1996-09-29T23:59:59.000Z

471

Contractor Human Resource Management Programs  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. This order cancels DOE O 3220.1A, DOE O 3220.4A, DOE O 3220.6A, and DOE O 3309.1A.

1996-09-30T23:59:59.000Z

472

The Human Eye June 4, 2009  

E-Print Network [OSTI]

The Human Eye T. Albers June 4, 2009 1 #12;1 Abstract The eyes provide a profound part of the human in my research. The eye is a biological system and, as such, does not lend itself to simplification Introduction Upon researching the human eye I have found it to be an exquisitely engineered piece of equipment

La Rosa, Andres H.

473

Policy Title: Human Subject Responsible Office: UFS  

E-Print Network [OSTI]

Policy Title: Human Subject Payments Responsible Office: UFS HARVARD UNIVERSITY FINANCIAL POLICY Effective Date: 1/1/11 Revision Date: N/A HUMAN SUBJECT PAYMENTS Policy Number TAX102 HARVARD UNIVERSITY FINANCIAL POLICY POLICY STATEMENT Individuals conducting Harvard research studies that compensate human

Chen, Yiling

474

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES The College of Architecture, Arts and Humanities offers graduate programs in three schools: the School in Architecture; City and Regional Planning; Construction Science and Management; Digital Pro- duction Arts

Stuart, Steven J.

475

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

25 College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES The College of Architecture, Arts and Humanities offers graduate programs in three schools: the School in Architecture; City and Regional Planning; Construction Science and Management; Digital Pro- duction Arts

Stuart, Steven J.

476

College of Architecture, Arts, and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

56 College of Architecture, Arts, and Humanities 56 COLLEGE OF ARCHITECTURE, ARTS, AND HUMANITIES The collaboration of Architecture (Landscape Ar- chitecture, Construction Science and Management, City and Regional Planning, and Architecture) with Arts (Visual Arts and Performing Arts) and the Humanities (Communication

Stuart, Steven J.

477

College of Architecture, Arts, and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

57 College of Architecture, Arts, and Humanities COLLEGE OF ARCHITECTURE, ARTS, AND HUMANITIES The collaboration of Architecture (Landscape Ar- chitecture, Construction Science and Management, City and Regional Planning, and Architecture) with Arts (Visual Arts and Performing Arts) and the Humanities (Communication

Stuart, Steven J.

478

Human Resources Recruiting Contracts 2013 2014  

E-Print Network [OSTI]

Human Resources Recruiting Contracts 2013 ­ 2014 Department of Human Resources | Prepared by David Ferraro | July 1, 2013 #12;The Department of Human Resources provides the attached advertising contracts resources provide a national and international presence while others are focused more regionally

Crawford, T. Daniel

479

HUMAN RESOURCES MANUAL SECTION 1: GENERAL PROVISIONS  

E-Print Network [OSTI]

HUMAN RESOURCES MANUAL SECTION 1: GENERAL PROVISIONS 1 | P a g e S e c t i o n 1 Purpose The purpose of this Human Resources Manual is to: 1. Provide the personnel and payroll policies and procedures, regulations and benefits. 3. Establish requirements and instructions for submission of Human Resources System

480

DEPARTMENT OF HUMAN DIMENSIONS OF NATURAL RESOURCES  

E-Print Network [OSTI]

CODE DEPARTMENT OF HUMAN DIMENSIONS OF NATURAL RESOURCES College of Natural Resources Colorado;3 DEPARTMENT OF NATURAL HUMAN DIMENSIONS OF NATURAL RESOURCES CODE ARTICLE I. GOAL AND OBJECTIVES A. DEPARTMENT MISSION The mission of the Department of Human Dimensions of Natural Resources is to contribute

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Reflections on the human prospect  

SciTech Connect (OSTI)

World population and the global economy are expanding in a manner that is propelling civilization along a path that is unsustainable, inequitable, and unstable. A concerted, global effort to discover, integrate, disseminate, and apply knowledge about the natural world and human behavior would change this trajectory to a path of sustainable human development. This path would point toward the vision of a society in which the basic human needs and an equitable share of life`s amenities could be met by successive generations while maintaining in perpetuity a health, physically attractive, and biologically productive environment. The scholarly community is urged to provide impetus for the pursuit of this vision. An unprecedented degree of collaboration among the disciplines will be necessary. New modes of communication and cooperation among the major sectors of society will have to be fashioned. Knowledge will become an organizing principle for society in the twenty-first century. Climate change has resulted from continuing economic and demographic growth. To stabilize world climate, the emission of greenhouse gases must be controlled. 57 refs.

Malone, T.F. [Sigma Xi Center, Research Triangle Park, NC (United States); [North Carolina State Univ., Raleigh, NC (United States)

1995-11-01T23:59:59.000Z

482

Integrating Human Performance and Technology  

SciTech Connect (OSTI)

Human error is a significant factor in the cause and/or complication of events that occur in the commercial nuclear industry. In recent years, great gains have been made using Human Performance (HU) tools focused on targeting individual behaviors. However, the cost of improving HU is growing and resistance to add yet another HU tool certainly exists, particularly for those tools that increase the paperwork for operations. Improvements in HU that are the result of leveraging existing technology, such as hand-held mobile technologies, have the potential to reduce human error in controlling system configurations, safety tag-outs, and other verifications. Operator rounds, valve line-up verifications, containment closure verifications, safety & equipment protection, and system tagging can be supported by field-deployable wireless technologies. These devices can also support the availability of critical component data in the main control room and other locations. This research pilot project reviewing wireless hand-held technology is part of the Light Water Reactor Sustainability Program (LWRSP), a research and development (R&D) program sponsored by the U. S. Department of Energy (DOE). The project is being performed in close collaboration with industry R&D programs to provide the technical foundations for licensing, and managing the long-term, safe, and economical operation of current nuclear power plants. The LWRSP vision is to develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current nuclear reactor fleet.

Ronald K. Farris; Heather Medema

2012-05-01T23:59:59.000Z

483

HUMANITIES  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun with Big Sky9, 2010 The meeting wasEngineering andHQHSI Bestscientists

484

Limited Chemotherapy and Shrinking Field Radiotherapy for Osteolymphoma (Primary Bone Lymphoma): Results From the Trans-Tasman Radiation Oncology Group 99.04 and Australasian Leukaemia and Lymphoma Group LY02 Prospective Trial;Bone; Lymphoma; Radiotherapy; Chemotherapy; Clinical trial  

SciTech Connect (OSTI)

Purpose: To establish benchmark outcomes for combined modality treatment to be used in future prospective studies of osteolymphoma (primary bone lymphoma). Methods and Materials: In 1999, the Trans-Tasman Radiation Oncology Group (TROG) invited the Australasian Leukemia and Lymphoma Group (ALLG) to collaborate on a prospective study of limited chemotherapy and radiotherapy for osteolymphoma. The treatment was designed to maintain efficacy but limit the risk of subsequent pathological fractures. Patient assessment included both functional imaging and isotope bone scanning. Treatment included three cycles of CHOP chemotherapy and radiation to a dose of 45 Gy in 25 fractions using a shrinking field technique. Results: The trial closed because of slow accrual after 33 patients had been entered. Accrual was noted to slow down after Rituximab became readily available in Australia. After a median follow-up of 4.3 years, the five-year overall survival and local control rates are estimated at 90% and 72% respectively. Three patients had fractures at presentation that persisted after treatment, one with recurrent lymphoma. Conclusions: Relatively high rates of survival were achieved but the number of local failures suggests that the dose of radiotherapy should remain higher than it is for other types of lymphoma. Disability after treatment due to pathological fracture was not seen.

Christie, David, E-mail: david.christie@premion.com.au [Premion and Bond University, Gold Coast, Queensland (Australia); Dear, Keith [Department of Epidemiology and Population Studies, Australian National University, Canberra, New South Wales (Australia); Le, Thai [BHB, Premion, Brisbane, Queensland (Australia); Barton, Michael [Collaboration for Cancer Outcomes and Research (CCORE) and University of NSW, Sydney, New South Wales (Australia); Wirth, Andrew [Peter MacCallum Cancer Institute, Melbourne, Victoria (Australia); Porter, David [Auckland Hospital, Auckland (New Zealand); Roos, Daniel [Royal Adelaide Hospital, Adelaide, South Australia (Australia); Pratt, Gary [Royal Brisbane Hospital, Brisbane, Queensland (Australia)

2011-07-15T23:59:59.000Z

485

The LIRIS Human activities dataset and the ICPR 2012 human activities recognition and localization competition  

E-Print Network [OSTI]

The LIRIS Human activities dataset and the ICPR 2012 human activities recognition and localization-69621, France March 28, 2012 Abstract We describe the LIRIS human activities dataset, the dataset used competitions and existing datasets, the tasks focus on complex human behavior involving several people

Wolf, Christian

486

Fourth National Report on Human Exposure to Environmental Chemicals Fourth National Report on Human Exposure to  

E-Print Network [OSTI]

for Disease Control and Prevention #12;Fourth National Report on Human Exposure to Environmental Chemicals i2009 Fourth National Report on Human Exposure to Environmental Chemicals #12;Fourth National Report on Human Exposure to Environmental Chemicals 2009 Department of Health and Human Services Centers

487

Interactive Manipulation Between a Human and a Humanoid: When Robots Control Human Arm Motion  

E-Print Network [OSTI]

, humanoids and anthropo- morphic designs can facilitate the human/robot interaction, because peopleInteractive Manipulation Between a Human and a Humanoid: When Robots Control Human Arm Motion Bruno a novel approach in human/robot collaboration, where the robot controls not only its arm but also

Boyer, Edmond

488

HUMAN RESOURCES WORKING GROUP: ACTION PLAN VISION PRIORITY: MAXIMIZING OUR HUMAN RESOURCES  

E-Print Network [OSTI]

HUMAN RESOURCES WORKING GROUP: ACTION PLAN VISION PRIORITY: MAXIMIZING OUR HUMAN RESOURCES, and student body." From David Ward, "A Vision for the Future," p. 9. This document lists the human-resource goals and plans of the Office of Human Resources, the Equity and Diversity Resource Center

Sheridan, Jennifer

489

Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium  

E-Print Network [OSTI]

†, [8,9] Carrie Nielson, [10] Priya Srikanth, [10] Sylvie Giroux, [11] Scott G Wilson, [2,12,13] Hou-Feng Zheng, [14] Albert V Smith, [15,16] Stephen R Pye, [17] Paul J Leo, [18] Alexander Teumer, [19] Joo-Yeon Hwang, [20] Claes Ohlsson, [21] Fiona Mc... Email: stephen@srl.cam.ac.uk Tel : +44 1223 748668 Fax: +44 1223 748658 5   ABSTRACT Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by x...

Moayyeri, Alireza; Hsu, Yi-Hsiang; Karasik, David; Estrada, Karol; Xiao, Su-Mei; Nielson, Carrie; Srikanth, Priya; Giroux, Sylvie; Wilson, Scott G.; Zheng, Hou-Feng; Smith, Albert V.; Pye, Stephen R.; Leo, Paul J.; Teumer, Alexander; Hwang, Joo-Yeon; Ohlsson, Claes; McGuigan, Fiona; Minster, Ryan L.; Hayward, Caroline; Olmos, José M.; Lyytikäinen, Leo-Pekka; Lewis, Joshua R.; Swart, Karin M. A.; Masi, Laura; Oldmeadow, Chris; Holliday, Elizabeth G.; Cheng, Sulin; van Schoor, Natasja M.; Harvey, Nicholas C.; Kruk, Marcin; Del Greco M, Fabiola; Igl, Wilmar; Trummer, Olivia; Grigoriou, Efi; Luben, Robert; Liu, Ching-Ti; Zhou, Yanhua; Oei, Ling; Medina-Gomez, Carolina; Zmuda, Joseph; Tranah, Greg; Brown, Suzanne J.; Williams, Frances M.; Soranzo, Nicole; Jakobsdottir, Johanna; Siggeirsdottir, Kristin; Holliday, Kate L.; Hannemann, Anke; Go, Min Jin; Garcia, Melissa; Polasek, Ozren; Laaksonen, Marika; Zhu, Kun; Enneman, Anke W.; McEvoy, Mark; Peel, Roseanne; Sham, Pak Chung; Jaworski, Maciej; Johansson, Åsa; Hicks, Andrew A.; Pludowski, Pawel; Scott, Rodney; Dhonukshe-Rutten, Rosalie A. M.; van der Velde, Nathalie; Kähönen, Mika; Viikari, Jorma S.; Sievänen, Harri; Raitakari, Olli T.; González-Macías, Jesús; Hernández, Jose L.; Mellström, Dan; Ljunggren, Östen; Cho, Yoon Shin; Völker, Uwe; Nauck, Matthias; Homuth, Georg; Völzke, Henry; Haring, Robin; Brown, Matthew A.; McCloskey, Eugene; Nicholson, Geoffrey C.; Eastell, Richard; Eisman, John A.; Jones, Graeme; Reid, Ian R.; Dennison, Elaine M.; Wark, John; Boonen, Steven; Vanderschueren, Dirk; Wu, Frederick C. W.; Aspelund, Thor; Richards, J. Brent; Bauer, Doug; Hofman, Albert; Khaw, Kay-Tee; Dedoussis, George; Obermayer-Pietsch, Barbara; Gyllensten, Ulf; Pramstaller, Peter P.; Lorenc, Roman S.; Cooper, Cyrus; Kung, Annie Wai Chee; Lips, Paul; Alen, Markku; Attia, John; Brandi, Maria Luisa; de Groot, Lisette C. P. G. M.; Lehtimäki, Terho; Riancho, José A.; Campbell, Harry; Liu, Yongmei; Harris, Tamara B.; Akesson, Kristina; Karlsson, Magnus; Lee, Jong-Young; Wallaschofski, Henri; Duncan, Emma L.; O'Neill, Terence W.; Gudnason, Vilmundur; Spector, Timothy D.; Rousseau, François; Orwoll, Eric; Cummings, Steve; Wareham, Nick J.; Rivadeneira, Fernando; Uitterlinden, Andre G.; Prince, Richard L.; Kiel, Douglas P.; Reeve, Jonathan; Kaptoge, Stephen K.

2014-01-14T23:59:59.000Z

490

Pin loosening in external skeletal fixation: a biomechanical and microstructural comparison of the near and far cortex pin-bone interfaces  

E-Print Network [OSTI]

ANO FAR CORTEX PIN-BONE INTERFACES A Thesis by DARRYL EUGENE MCDONALD, JR. Approved as to style and content by: Donald . Hu se (Chair of Committee) Ross H. Palmer (Member) Wi)1 A. Hyman ember) Margaret R. Slater (Member) John R. ust (Head... of Department) August 1993 ABSTRACT Pin Loosening in External Skeletal Fixation: A Biomechanical and Microstructural Comparison of the Near and Far Cortex Pin-Bone Interfaces. (August 1993) Darryl Eugene McDonald, Jr. , B. S. ; B. S. ; D. V. M. , Texas...

McDonald, Darryl Eugene

1993-01-01T23:59:59.000Z

491

Substitution of meat and bone meal and cottonseed meal for soybean meal on a digestible amino acid basis in growing pig diets  

E-Print Network [OSTI]

SUBSTITUTION OF MEAT AND BONE MEAL AND COTTONSEED AREAL FOR SOyBEAN MEAL ON A DIGESTIBLE AMINO ACID BASIS IN GROWING PIG DIETS A Thesis by CARL HEINZ DOBLER-MEHNER Submitted to the Graduate College of Texas A&M University in partial... fulfillment of the requirements for the degree of MASTER OF SCIENCE May 1982 Major Subject: Animal Science SUBSTITUTION OF MEAT AND BONE MEAL AND COTTONSEED MEAL FOR SOYBEAN MEAL ON A DIGESTIBLE AMINO ACID BASIS IN GROWING PIG DIETS A Thesis by CARL...

Dobler-Mehner, Carl Heinz

1982-01-01T23:59:59.000Z

492

Strategic Use of Human Capital | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Human Capital Strategic Use of Human Capital A report on how the DOE uses and plans to reform their use of human capital. Strategic Use of Human Capital More Documents &...

493

NUMBER: HR 1.85 SECTION: Human Resources  

E-Print Network [OSTI]

NUMBER: HR 1.85 SECTION: Human Resources SUBJECT: Research Grant or Time-limited Positions DATE: Chris Byrd Issued by: Division of Human Resources OF HUMAN RESOURCES HAS THE AUTHORITY TO INTERPRET THE UNIVERSITY'S HUMAN RESOURCES POLICIES

Almor, Amit

494

Contractor Human Resource Management Programs  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This directive establishes DOE responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. DOE O 350.1 Chg 5, dated 9-30-2014, cancels DOE O 350.1 Chg 4. The Order is revised to reflect the cancellation of Chapters 1-3 due to the incorporation of these chapters into DOE Order 350.3; reflect organizational changes; delete reference to the DOE Retrospective Rating Insurance Plan, which is no longer available; remove the CRD from Chapter VII.

1996-09-30T23:59:59.000Z

495

Simulation of human decision making  

DOE Patents [OSTI]

A method for computer emulation of human decision making defines a plurality of concepts related to a domain and a plurality of situations related to the domain, where each situation is a combination of at least two of the concepts. Each concept and situation is represented in the computer as an oscillator output, and each situation and concept oscillator output is distinguishable from all other oscillator outputs. Information is input to the computer representative of detected concepts, and the computer compares the detected concepts with the stored situations to determine if a situation has occurred.

Forsythe, J. Chris (Sandia Park, NM); Speed, Ann E. (Albuquerque, NM); Jordan, Sabina E. (Albuquerque, NM); Xavier, Patrick G. (Albuquerque, NM)

2008-05-06T23:59:59.000Z

496

Human Resources | The Ames Laboratory  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickr FlickrGuidedCH2MLLC HistoryVeteransto getEmployee RelationsHuman

497

ORISE: Protecting Human Subjects Website  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas Conchas recoveryLaboratory |CHEMPACK MappingHistory TheManagementProcess andProtecting Human

498

Human Genome Research: Decoding DNA  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinement plasmas inPortalAllBPA addressesHowHughHumanDecoding DNA

499

China and the Humanities: At the Crossroads of the Human and the Humane  

E-Print Network [OSTI]

to legitimatize their own rule. However unlike the Manchu rulers, his analysis reveals only a dark portent for the future of Chinese civilization. Part Three Humanities’ Mark on People |???????? The five chapters of part three of this volume revolve around... or Virginia Woolf Academic Web] (http://globe.eworkway.com) that provides an im- portant on-line venue for Chinese academics and readers who are devoted to the life and works of Virginia Woolf. Judy LATTAS Judy Lattas is the Director of the Interdisciplinary...

Tchou, W. Kang

2013-01-01T23:59:59.000Z

500

Low-Level Accelerations Applied in the Absence of Weight Bearing Can Enhance Trabecular  

E-Print Network [OSTI]

of skeletal regions that are prone to osteoporosis even in patients that are suffering from confinement; cortical bone; trabecular bone; morphology; osteoporosis; mouse INTRODUCTION The skeleton may respond bone's mechanosensitivty to strengthen the skeleton and to retard diseases such as osteoporosis have