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Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic...

2

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Irradiation Effects on Human Cortical Bone Fracture Behavior Irradiation Effects on Human Cortical Bone Fracture Behavior Print Wednesday, 28 July 2010 00:00 Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

3

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

4

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

5

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

6

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

7

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

above a micron, toughening mechanisms can be markedly changed. Cortical bones' resistance to fracture in the transverse (breaking) orientation can be associated with...

8

Aging and Fracture of Human Cortical Bone and Tooth Dentin  

SciTech Connect

Mineralized tissues, such as bone and tooth dentin, serve as structural materials in the human body and, as such, have evolved to resist fracture. In assessing their quantitative fracture resistance or toughness, it is important to distinguish between intrinsic toughening mechanisms which function ahead of the crack tip, such as plasticity in metals, and extrinsic mechanisms which function primarily behind the tip, such as crack bridging in ceramics. Bone and dentin derive their resistance to fracture principally from extrinsic toughening mechanisms which have their origins in the hierarchical microstructure of these mineralized tissues. Experimentally, quantification of these toughening mechanisms requires a crack-growth resistance approach, which can be achieved by measuring the crack-driving force, e.g., the stress intensity, as a function of crack extension ("R-curve approach"). Here this methodology is used to study of the effect of aging on the fracture properties of human cortical bone and human dentin in order to discern the microstructural origins of toughness in these materials.

Ager, Joel; Koester, Kurt J.; Ager III, Joel W.; Ritchie, Robert O.

2008-05-07T23:59:59.000Z

9

Effect of aging on the toughness of human cortical bone: evaluation by R-curves  

E-Print Network (OSTI)

Effect of aging on the toughness of human cortical bone: evaluation by R-curves R.K. Nallaa,b , J online 27 October 2004 Abstract Age-related deterioration of the fracture properties of bone, coupled, and hence, an understanding of how its fracture properties degrade with age is essential. The present study

Ritchie, Robert

10

How Tough is Human Cortical Bone? In-Situ Measurements on Realistically Short Cracks  

SciTech Connect

Bone is more difficult to break than to split. Although this is well known, and many studies exist on the behavior of long cracks in bone, there is a need for data on the orientation-dependent crack-growth resistance behavior of human cortical bone which accurately assesses its toughness at appropriate size-scales. Here we use in-situ mechanical testing in the scanning electron microscope and x-ray computed tomography to examine how physiologically-pertinent short (<600 mu m) cracks propagate in both the transverse and longitudinal orientations in cortical bone, using both crack-deflection/twist mechanics and nonlinear-elastic fracture mechanics to determine crack-resistance curves. We find that after only 500 mu m of cracking, the driving force for crack propagation was more than five times higher in the transverse (breaking) direction than in the longitudinal (splitting) direction due to major crack deflections/twists principally at cement sheathes. Indeed, our results show that the true transverse toughness of cortical bone is far higher than previously reported. However, the toughness in the longitudinal orientation, where cracks tend to follow the cement lines, is quite low at these small crack sizes; it is only when cracks become several millimeters in length that bridging mechanisms can develop leading to the (larger-crack) toughnesses generally quoted for bone.

Ritchie, Robert O; Koester, K. J.; Ager III, J. W.; Ritchie, R.O.

2008-05-10T23:59:59.000Z

11

How Tough is Human Cortical Bone? In-Situ Measurements on Realistically Short Cracks  

Science Conference Proceedings (OSTI)

Bone is more difficult to break than to split. Although this is well known, and many studies exist on the behavior of long cracks in bone, there is a need for data on the orientation-dependent crack-growth resistance behavior of human cortical bone which accurately assesses its toughness at appropriate size-scales. Here we use in-situ mechanical testing in the scanning electron microscope and x-ray computed tomography to examine how physiologically-pertinent short (propagate in both the transverse and longitudinal orientations in cortical bone, using both crack-deflection/twist mechanics and nonlinear-elastic fracture mechanics to determine crack-resistance curves. We find that after only 500 mu m of cracking, the driving force for crack propagation was more than five times higher in the transverse (breaking) direction than in the longitudinal (splitting) direction due to major crack deflections/twists principally at cement sheathes. Indeed, our results show that the true transverse toughness of cortical bone is far higher than previously reported. However, the toughness in the longitudinal orientation, where cracks tend to follow the cement lines, is quite low at these small crack sizes; it is only when cracks become several millimeters in length that bridging mechanisms can develop leading to the (larger-crack) toughnesses generally quoted for bone.

Ritchie, Robert O; Koester, K. J.; Ager III, J. W.; Ritchie, R.O.

2008-05-10T23:59:59.000Z

12

Aging and Fracture of Human Cortical Bone and Tooth Dentin  

E-Print Network (OSTI)

et al. , The effect of aging on crack-growth resistance andR.K. Reprogel, Effects of aging on the mechanical behaviorNalla et al. , Effect of aging on the toughness of human

Ager III, Joel W.

2008-01-01T23:59:59.000Z

13

Age-related changes in the plasticity and toughness of human cortical bone at multiple length-scales  

SciTech Connect

The structure of human cortical bone evolves over multiple length-scales from its basic constituents of collagen and hydroxyapatite at the nanoscale to osteonal structures at nearmillimeter dimensions, which all provide the basis for its mechanical properties. To resist fracture, bone’s toughness is derived intrinsically through plasticity (e.g., fibrillar sliding) at structural-scales typically below a micron and extrinsically (i.e., during crack growth) through mechanisms (e.g., crack deflection/bridging) generated at larger structural-scales. Biological factors such as aging lead to a markedly increased fracture risk, which is often associated with an age-related loss in bone mass (bone quantity). However, we find that age-related structural changes can significantly degrade the fracture resistance (bone quality) over multiple lengthscales. Using in situ small-/wide-angle x-ray scattering/diffraction to characterize sub-micron structural changes and synchrotron x-ray computed tomography and in situ fracture-toughness measurements in the scanning electron microscope to characterize effects at micron-scales, we show how these age-related structural changes at differing size-scales degrade both the intrinsic and extrinsic toughness of bone. Specifically, we attribute the loss in toughness to increased non-enzymatic collagen cross-linking which suppresses plasticity at nanoscale dimensions and to an increased osteonal density which limits the potency of crack-bridging mechanisms at micron-scales. The link between these processes is that the increased stiffness of the cross-linked collagen requires energy to be absorbed by “plastic” deformation at higher structural levels, which occurs by the process of microcracking.

Zimmermann, Elizabeth A.; Schaible, Eric; Bale, Hrishikesh; Barth, Holly D.; Tang, Simon Y.; Reichert, Peter; Busse, Bjoern; Alliston, Tamara; Ager III, Joel W.; Ritchie, Robert O.

2011-08-10T23:59:59.000Z

14

The Effects of Obesity on Murine Cortical Bone  

E-Print Network (OSTI)

34, 376 (2004). S. S. Ionova-Martin, et al. , Bone 46, 217 (Cortical Bone by Sophi Martin A dissertation submitted inMurine Cortical Bone by Sophi Martin ABSTRACT The Effects of

Martin, Sophi

2010-01-01T23:59:59.000Z

15

E13: An Experimentally-based Flow Stress Model for Cortical Bone  

Science Conference Proceedings (OSTI)

Developed here is a micro-scale-based flow stress model of cortical bone. In order to ... Catalysts by Using the Metal Ion-reducing Bacterium Shewanella Algae.

16

Irradiation Effects on Human Cortical Bone Fracture Behavior  

NLE Websites -- All DOE Office Websites (Extended Search)

crack bridging by collagen fibrils. At the largest length-scales (10's to 100's m), the primary sources of toughening are extrinsic and result from extensive crack deflection and...

17

On the multiscale origins of fracture resistance in human bone and its biological degradation  

SciTech Connect

Akin to other mineralized tissues, human cortical bone can resist deformation and fracture due to the nature of its hierarchical structure, which spans the molecular to macroscopic length-scales. Deformation at the smallest scales, mainly through the composite action of the mineral and collagen, contributes to bone?s strength or intrinsic fracture resistance, while crack-tip shielding mechanisms active on the microstructural scale contribute to the extrinsic fracture resistance once cracking begins. The efficiency with which these structural features can resist fracture at both small and large length-scales becomes severely degraded with such factors as aging, irradiation and disease. Indeed aging and irradiation can cause changes to the cross-link profile at fibrillar length-scales as well as changes at the three orders of magnitude larger scale of the osteonal structures, both of which combine to inhibit the bone's overall resistance to the initiation and growth of cracks.

Zimmermann, Elizabeth A.; Barth, Holly D.; Ritchie, Robert O.

2012-03-09T23:59:59.000Z

18

Fracture, aging and disease in bone  

E-Print Network (OSTI)

and R. O. Ritchie: Effect of aging on the toughness of humanof microstructure in the aging-related deterioration of thestudy of the effect of aging on human cortical bone J.

Ager, J.W.; Balooch, G.; Ritchie, R.O.

2006-01-01T23:59:59.000Z

19

Neural correlates of auditory perceptual organization measured with direct cortical recordings in humans  

E-Print Network (OSTI)

One of the primary functions of the human auditory system is to separate the complex mixture of sound arriving at the ears into neural representations of individual sound sources. This function is thought to be crucial for ...

Dykstra, Andrew R. (Andrew Richard)

2011-01-01T23:59:59.000Z

20

Nanomechanics and ultrastructural studies of cortical bone : fundamental insights regarding structure-function, mineral-organic force mechanics interactions, and heterogeneity  

E-Print Network (OSTI)

Although the mechanics of bone has been studied extensively at the micro- and macro-scale, the nano-scopic level is perhaps the most illuminating as this is the length scale at which the individual constituents interact. ...

Tai, Kuangshin

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Flaxseed in Human Nutrition, 2nd EditionChapter 17 Effect of Flaxseed on Bone Metabolism and Menopauseolism and Menopause  

Science Conference Proceedings (OSTI)

Flaxseed in Human Nutrition, 2nd Edition Chapter 17 Effect of Flaxseed on Bone Metabolism and Menopause olism and Menopause Food Science Health Nutrition Biochemistry eChapters Food Science & Technology Health - Nutrition - Biochemistry

22

On the effect of x-ray irradiation on the deformation and fracture behavior of human cortical bone  

E-Print Network (OSTI)

split  polypeptide  chains;  in  wet  specimens,  irradiation  causes  release  of  free  radicals  via  radiolysis  of  water molecules 

Barth, Holly D.

2010-01-01T23:59:59.000Z

23

Cortical Folding Patterns and Predicting Cytoarchitecture  

E-Print Network (OSTI)

The human cerebral cortex is made up of a mosaic of structural areas, frequently referred to as Brodmann areas (BAs). Despite the widespread use of cortical folding patterns to perform ad hoc estimations of the locations ...

Rajendran, Niranjini

24

Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation  

E-Print Network (OSTI)

Adipose tissue-derived stem cells (ASCs) are considered as an attractive stem cell source for tissue engineering and regenerative medicine. We compared human bone marrow-derived mesenchymal stem cells (hMSCs) and hASCs ...

Park, Sang-Hyug

25

Bone Canonical WNT/B-Catenin Signaling in Models of Reduced Microgravity  

E-Print Network (OSTI)

Human exposure to reduced weightbearing results in bone loss. The rate of bone loss during microgravity exposure is similar to that of a post-menopausal women. In fact, the maintenance of bone mass is intimately dependent on exercise. Therefore, exercise associated mechanical loads to bone tissue are an important countermeasure to prevent disuse-induced bone loss. However, the types of exercise modalities required to prevent such bone loss are unclear. Moreover, how mechanical loading to bone translates into molecular osteogenic signals in bone cells is unknown. Radiation exposure is another potent inducer of bone loss, namely observed on Earth in the clinical setting following radiotherapy procedures. It is expected that long duration space missions outside the protection of Earth’s magnetosphere will result in significant galactic cosmic radiation exposure. However, the magnitude of bone loss resulting from this galactic cosmic radiation exposure is unclear. Moreover, it is unknown if radiation exposure will exacerbate disuse-induced bone loss. Therefore, a series of experiments were designed to determine: 1) Will simulated galactic cosmic radiation exacerbate reduced weightbearing-induced bone loss? 2) Will pharmacological activation of the putative mechanosensing Wnt pathway enhance exercise-induced bone mass gain? To address these questions the experimental study series employed two animal models of reduced weightbearing, hindlimb unloading and partial weightbearing. These model test-beds enabled the evaluation of two novel countermeasures (simulated resistance exercise and glycogen synthase kinase-3 (GSK-3) therapeutic) and simulated exposure to space radiation environments. To test the impact of simulated space radiation (28Si) one study of the series was conducted at Brookhaven National Laboratory. To quantify the impact of the abovementioned countermeasures and space radiation on bone, mechanical testing, peripheral quantitative computed tomography, micro-computed tomography, histomorphometry, and immunohistochemistry served as primary outcome measures. The primary findings are: 1) Low-dose high-LET radiation negativity impacts maintenance of bone mass by lowering bone formation and increasing bone resorption. This impaired bone formation response is in part due to sclerostin induced suppression of Wnt signaling. 2) Combining GSK-3 inhibition with high intensity exercise mitigates cancellous bone loss and restores cortical periosteal growth during disuse.

Macias, Brandon 1979-

2012-12-01T23:59:59.000Z

26

Biodegradable synthetic bone composites  

DOE Patents (OSTI)

The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component; such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

Liu, Gao; Zhao, Dacheng; Saiz, Eduardo; Tomsia, Antoni P.

2013-01-01T23:59:59.000Z

27

Bioactive Glass Scaffolds for Bone Regeneration  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

28

Bioactive Glass Scaffolds for Bone Regeneration  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

29

Bioactive Glass Scaffolds for Bone Regeneration  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioactive Glass Scaffolds for Bioactive Glass Scaffolds for Bone Regeneration Bioactive Glass Scaffolds for Bone Regeneration Print Wednesday, 28 September 2011 00:00 Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

30

Bioactive Glass Scaffolds for Bone Regeneration  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

31

Bioactive Glass Scaffolds for Bone Regeneration  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

32

ORIGINAL INVESTIGATION Increased cortical inhibition deficits in first-episode  

E-Print Network (OSTI)

# The Author(s) 2009. This article is published with open access at Springerlink.com Rationale/objectives There is a high prevalence of substance use disorder (SUD) in first-episode schizophrenia (SZ), but its contribution to the underlying SZ pathophysiology remains unclear. Several studies using transcranial magnetic stimulation (TMS) have observed abnormalities in human motor cortex (M1) excitability in SZ. Studies on cortical excitability comparing SZ patients with and without comorbid substance abuse are lacking. Methods A total of 29 first-episode SZ patients participated in this study; 12 had a history of comorbid cannabis abuse (SZ-SUD) and 17 did not (SZ-NSUD). We applied TMS to right and left M1 areas to assess the resting motor threshold (RMT), short-interval cortical inhibition (SICI), intracortical facilitation (ICF), and the contralateral cortical silent period (CSP). Results In SICI and ICF conditions, right M1 stimulation led to significantly higher motor evoked potential ratios in SZ-SUD compared to SZ-NSUD. This suggests lower cortical inhibition and increased ICF in first-episode SZ T. Wobrock and A. Hasan contributed equally.

N. Lang; U. K. H. Ecker

2009-01-01T23:59:59.000Z

33

Effects of High Dietary Iron and Gamma Radiation on Oxidative Stress and Bone  

E-Print Network (OSTI)

Astronauts in space flight missions are exposed to increased iron (Fe) stores and galactic cosmic radiation, both of which independently induce oxidative stress. Oxidative stress can result in protein, lipid, and DNA oxidation. Recent evidence has linked oxidative stress to bone loss with aging and estrogen deficiency. Whether the increased iron stores and radiation that astronauts face are exacerbating their extreme bone loss while in space is unclear. We hypothesized that elevated iron levels (induced by feeding a high iron diet) and gamma radiation exposure would independently increase markers of oxidative stress and markers of oxidative damage and result in loss of bone mass, with the combined treatment having additive or synergistic effects. Male Sprague-Dawley rats (15-weeks old, n=32) were randomized to receive an adequate (45 mg Fe/kg diet) or high (650 mg Fe/kg diet) Fe diet for 4 weeks and either 3 Gy (8 fractions, 0.375 Gy each) of 137Cs radiation (?RAD) or sham exposure every other day over 16 days starting on day 14. Serum Fe and catalase and liver Fe and glutathione peroxidase (GPX) were assessed by standard techniques. Immunostaining for 8-hydroxy-2-deoxyguanosine (8-OHdG, marker of DNA adducts) quantified the number of cells with oxidative damage in cortical bone. Bone histomorphometry assessed bone cell activity and cancellous bone microarchitecture in the metaphyseal region. Ex vivo pQCT quantified volumetric bone mineral density (vBMD); bone mechanical strength was assessed by 3-pt bending at the midshaft tibia and compression of the femoral neck. High Fe diet increased liver Fe and decreased volume per total volume (BV/TV). ?RAD decreased osteoid surface per bone surface (OS/BS) and osteocyte density. The combined treatment increased serum catalase, liver GPX, and serum iron and decreased cancellous vBMD and trabecular number (Tb.N). High Fe diet and ?RAD independently increased number of osteocytes stained positive for 8-OHdG, with the combined treatment exhibiting twice as many osteocytes positively stained compared to the control. Higher serum Fe levels were associated with higher oxidative damage (r =0.38) and lower proximal tibial cancellous vBMD (r =–0.38). Higher serum catalase levels were associated with higher oxidative damage (r =0.48), lower BV/TV (r =–0.40) and lower cancellous vBMD (r =–0.39). High dietary iron and fractionated 137Cs ?RAD leads to a moderate elevation in iron stores and results in oxidative damage in bone and are associated with decreased cancellous bone density. Moderate elevations in iron stores are not only found in astronauts, but also naturally occur in healthy human populations. This healthy population with elevated iron stores may also have increased levels of oxidative stress in the body. Elevated levels of oxidative stress not only increase one’s risk for accelerated bone loss, but also the risk of developing other chronic diseases such as insulin resistance, hypertension, dyslipidemia, and metabolic syndrome.

Yuen, Evelyn P

2013-05-01T23:59:59.000Z

34

Anatomy-based modeling of the human musculature  

Science Conference Proceedings (OSTI)

Keywords: articulated models, bones, deformations, human figure animation, muscles, procedural modeling, tendons

Ferdi Scheepers; Richard E. Parent; Wayne E. Carlson; Stephen F. May

1997-08-01T23:59:59.000Z

35

FGF-23 in bone biology  

E-Print Network (OSTI)

6 REVIEW FGF-23 in bone biology Katherine Wesseling-Perryin impairments in bone biology. Although the defectiveof the protein on bone biology, a growing compendium of data

Wesseling-Perry, Katherine

2010-01-01T23:59:59.000Z

36

ALSNews Vol. 311  

NLE Websites -- All DOE Office Websites (Extended Search)

1 Print Irradiation Effects on Human Cortical Bone Fracture Behavior The role irradiation plays in high-exposure bone fracturing experiments, and how it affects the properties of...

37

A9: Multiscale Modelling to Assess Elastic Properties of Cortical Bone  

Science Conference Proceedings (OSTI)

A8: Microstructural Investigation of Nano-Calcium Phosphates Doped with Fluoride Ions .... D7: Surfactant Structure–property Relationship: Effect of Polypropylene ... E4: The Effect of Monobutyl Ether Ethylene Glycol on the Conductivity and ...

38

Osteoporotic-like effects of cadmium on bone mineral density and content in aged ovariectomized beagles  

SciTech Connect

Our purpose was to evaluate the effects of ovariectomy in conjunction with cadmium (Cd) exposure on bone. Aged female beagles with {sup 45}Ca-labeled skeletons ovariectomized and exposed to Cd. Successive vertebral scans by dual photon absorptiometry monitored changes in bone mineral density (BMD) in each dog with time. Results showed that ovariectomy or Cd exposure alone caused significant decreases in BMD; ovariectomy with Cd exposure caused the greatest decrease. Ovariectomy alone did not decrease BMD in the distal end or mid-shaft of the tibia while BMD of the distal tibia decreased significantly due to Cd exposure alone. Combination treatment resulted in significant decreases in BMD of both tibial regions. At necropsy, tibiae, humeri, lumbar vertebrae and ribs were obtained for biochemical analysis. No group-to-group differences in bone weights (wet, dry, ash), in ash/dry ratios, or in long bone and vertebral Ca/dry or Ca/ash ratios were observed. Significantly higher total {sup 45}Ca content and {sup 45}Ca/dry and {sup 45}Ca/ash ratios were observed in long bones and vertebrae of OV- and OV+ groups. In contrast, intact ribs showed significantly decreased Ca/dry and Ca/ash ratios compared to the SO-group. Quartered ribs demonstrated regional responses to specific treatment; decreases in total Ca content were greatest in the mid-rib region ({minus}36 to {minus}46%). Results suggest that in the aged female beagle, bone mineral loss associated with estrogen depletion is not only related to bone type (trabecular versus cortical) but also to bone Ca pools. Our results also suggest that a regional heterogeneity of bone plays a role in responsiveness to ovariectomy and Cd exposure. These aspects suggest that Cd is an exogenous factor affecting bone mineral loss independently of estrogen depletion. However, estrogen depletion primes bone for responsiveness to Cd-induced bone mineral loss.

Sacco-Gibson, N.; Abrams, J.; Chaudhry, S.; Hurst, D.; Peterson, D.; Bhattacharyya, M.

1992-12-31T23:59:59.000Z

39

Modelling and simulation of acrylic bone cement injection and curing within the framework of vertebroplasty  

E-Print Network (OSTI)

The minimal invasive procedure of vertebroplasty is a surgical technique to treat compression fractures of vertebral bodies. During the treatment liquid bone cement gets injected into the affected vertebral body and therein cures to a solid. In order to investigate the treatment and the impact of injected bone cement on the vertebra, an integrated modelling and simulation framework has been developed. The framework includes (i) the generation of computer models based on microCT images of human cancellous bone, (ii) CFD simulations of bone cement injection into the trabecular structure of a vertebral body as well as (iii) non-linear FEM simulations of the bone cement curing. Thereby, microstructural models of trabecular bone structures are employed. Furthermore, a detailed description of the material behaviour of acrylic bone cements is provided. More precisely, a non-linear fluid flow model is chosen for the representation of the bone cement behaviour during injection and a non-linear viscoelastic material mo...

Landgraf, Ralf; Kolmeder, Sebastian; Lion, Alexander; Lebsack, Helena; Kober, Cornelia

2013-01-01T23:59:59.000Z

40

Methamphetamine induces heme oxygenase-1 expression in cortical neurons and glia to prevent its toxicity  

Science Conference Proceedings (OSTI)

The impairment of cognitive and motor functions in humans and animals caused by methamphetamine (METH) administration underscores the importance of METH toxicity in cortical neurons. The heme oxygenase-1 (HO-1) exerts a cytoprotective effect against various neuronal injures; however, it remains unclear whether HO-1 is involved in METH-induced toxicity. We used primary cortical neuron/glia cocultures to explore the role of HO-1 in METH-induced toxicity. Exposure of cultured cells to various concentrations of METH (0.1, 0.5, 1, 3, 5, and 10 mM) led to cytotoxicity in a concentration-dependent manner. A METH concentration of 5 mM, which caused 50% of neuronal death and glial activation, was chosen for subsequent experiments. RT-PCR and Western blot analysis revealed that METH significantly induced HO-1 mRNA and protein expression, both preceded cell death. Double and triple immunofluorescence staining further identified HO-1-positive cells as activated astrocytes, microglia, and viable neurons, but not dying neurons. Inhibition of the p38 mitogen-activated protein kinase pathway significantly blocked HO-1 induction by METH and aggravated METH neurotoxicity. Inhibition of HO activity using tin protoporphyrine IX significantly reduced HO activity and exacerbated METH neurotoxicity. However, prior induction of HO-1 using cobalt protoporphyrine IX partially protected neurons from METH toxicity. Taken together, our results suggest that induction of HO-1 by METH via the p38 signaling pathway may be protective, albeit insufficient to completely protect cortical neurons from METH toxicity.

Huang, Y.-N. [Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan 114 (China); Wu, C.-H. [Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan 114 (China); Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan 114 (China); Lin, T.-C. [Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan 114 (China); Wang, J.-Y., E-mail: jywang@ndmctsgh.edu.t [Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan 114 (China); Department of Physiology, National Defense Medical Center, Taipei, Taiwan 114 (China)

2009-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Cortical Surface-Based Analysis I. Segmentation and Surface Reconstruction  

E-Print Network (OSTI)

and flattening the cortical surface are described in a companion paper. These procedures allow for the routine and reprint requests should be ad- dressed. Fax: (617) 726-7422. E-mail: dale@nmr.mgh.harvard.edu. Neuro to preserve edges (Whitaker and Gerig, 1994), gray/white matter segmen- tation (Gerig and Kikinis, 1990; Gerig

Sereno, Martin

42

Digital electronic bone growth stimulator  

DOE Patents (OSTI)

A device is described for stimulating bone tissue by applying a low level alternating current signal directly to the patient`s skin. A crystal oscillator, a binary divider chain and digital logic gates are used to generate the desired waveforms that reproduce the natural electrical characteristics found in bone tissue needed for stimulating bone growth and treating osteoporosis. The device, powered by a battery, contains a switch allowing selection of the correct waveform for bone growth stimulation or osteoporosis treatment so that, when attached to the skin of the patient using standard skin contact electrodes, the correct signal is communicated to the underlying bone structures. 5 figs.

Kronberg, J.W.

1995-05-09T23:59:59.000Z

43

Digital electronic bone growth stimulator  

DOE Patents (OSTI)

A device for stimulating bone tissue by applying a low level alternating current signal directly to the patient's skin. A crystal oscillator, a binary divider chain and digital logic gates are used to generate the desired waveforms that reproduce the natural electrical characteristics found in bone tissue needed for stimulating bone growth and treating osteoporosis. The device, powered by a battery, contains a switch allowing selection of the correct waveform for bone growth stimulation or osteoporosis treatment so that, when attached to the skin of the patient using standard skin contact electrodes, the correct signal is communicated to the underlying bone structures.

Kronberg, James W. (Aiken, SC)

1995-01-01T23:59:59.000Z

44

Fracture, aging, and disease in bone J.W. Ager III  

E-Print Network (OSTI)

Fracture, aging, and disease in bone J.W. Ager III Materials Sciences Division, Lawrence Berkeley-known increase with age in fracture risk of human bone is essential. This also represents a challenge from accompanying the process of aging using appropriate multiscale experimental methods and relating them

Ritchie, Robert

45

About this Abstract  

Science Conference Proceedings (OSTI)

Mechanical Behavior in Human Cortical Bone Across Multiple Length Scales: ... Hydrogen-Accelerated Fatigue Crack Growth in a Low-Strength Pipeline Steel.

46

Leave-in-Place Laser Scanning for Fatigue Damage Monitoring and ...  

Science Conference Proceedings (OSTI)

Mechanical Behavior in Human Cortical Bone Across Multiple Length Scales: ... Hydrogen-Accelerated Fatigue Crack Growth in a Low-Strength Pipeline Steel.

47

The Effect of Trace Oxygen on Gaseous Hydrogen-Accelerated ...  

Science Conference Proceedings (OSTI)

Mechanical Behavior in Human Cortical Bone Across Multiple Length Scales: ... Hydrogen-Accelerated Fatigue Crack Growth in a Low-Strength Pipeline Steel.

48

In Situ Ultrahigh Temperature X-Ray Microtomography Facility for ...  

Science Conference Proceedings (OSTI)

Mechanical Behavior in Human Cortical Bone Across Multiple Length Scales: ... Hydrogen-Accelerated Fatigue Crack Growth in a Low-Strength Pipeline Steel.

49

Reply: Lithium and Increased Cortical Gray Matter--More Tissue or More Water?  

E-Print Network (OSTI)

Reply: Lithium and Increased Cortical Gray Matter--More Tissue or More Water? To the Editor: W e cortices, in lithium-treated patients with bipolar disorder, relative to healthy control subjects (1). Dr patients. Although lithium's effects on body water homeostasis (2) are important to consider, the absence

Thompson, Paul

50

Improved grating and bar cell models in cortical area V1 and texture coding  

Science Conference Proceedings (OSTI)

This paper presents improved models of cortical neurons in V1 that act like grating and bar detectors. Both models use the same frontend, which consists of a contrast normalisation in combination with isotropic DOG filtering, followed by anisotropic ... Keywords: Computational models, Cortical cells, Diatoms, Groupings, Symmetry order, Texture analysis

J. M. H. du Buf

2007-06-01T23:59:59.000Z

51

Elastic demons: characterizing cortical development in neonates using an implicit surface registration  

Science Conference Proceedings (OSTI)

We present an approach for nonrigid registration of consecutive neonatal cortical surfaces from MR images acquired at 30 and 40 week corrected gestational ages. Surfaces are registered implicitly using a method based on the Demons algorithm. Our key ...

Paul C. Pearlman; Ivana Išgum; Karina J. Kersbergen; Manon J. N. L. Benders; Max A. Viergever; Josien P. W. Pluim

2012-10-01T23:59:59.000Z

52

Going awol in the brain: Mind wandering reduces cortical analysis of external events  

Science Conference Proceedings (OSTI)

Converging evidence from neuroscience suggests that our attention to the outside world waxes and wanes over time. We examined whether these periods of mind wandering are associated with reduced cortical analysis of the external environment. Participants ...

Jonathan Smallwood; Emily Beach; Jonathan W. Schooler; Todd C. Handy

2008-03-01T23:59:59.000Z

53

Calcium balance and bone density in immature horses fed a high protein diet  

E-Print Network (OSTI)

Studies in other species indicate high protein diets increase urinary calcium (Ca) excretion and may lead to negative calcium balance and reduced bone density. As overfeeding of protein is commonplace in the horse industry, this study was undertaken to determine the effects of excess dietary protein on growth, physiologic response, mineral balance, bone density, and bone geometry in immature horses. Sixteen 10-month-old American Quarter Horses were blocked by age and sex into two dietary treatments. The control diet was formulated to provide the NRC (1989) recommended concentration of crude protein, while the high protein diet provided 130% of NRC (1989) recommendations. All other nutrients were formulated at or slightly above NRC (1989) recommendations. Blood samples, feces, and urine were collected during the 116-day study to determine any diet effect on pH and mineral balance. Radiographs were made of the left third metacarpal (MCIII) to determine bone density via radiographic bone aluminum equivalence (RBAE), and bone geometry was determined metrically from the radiographs. Urine pH decreased over time (p < 0.001), but there were no diet effects on blood pH or urine pH. Conversely, when normalized to day 0 values, fecal pH was reduced by feeding the high protein treatment (p < 0.02). Density of dorsal and palmar cortices increased over time (p < 0.001), but no differences were observed between diets. But, normalized total medial-lateral (ML) width of the MCIII was higher in the control diet (p < 0.05). Fecal Ca loss was greater in horses fed the high protein diet (p < 0.005), while Ca absorption and retention were lower for horses on the high protein treatment (p < 0.02). Phosphorus (P) balance was not different between diets, although feeding the high protein diet resulted in higher P intake overall (p < 0.001). While excess dietary protein may decrease fecal pH, increase fecal Ca excretion, and decrease Ca absorption and retention, there was no consistent effect of the high protein diet on bone density over the course of this study. Further research is necessary to determine if feeding high-protein diets is detrimental to bone quality in the growing horse.

Spooner, Holly Sue

2005-08-01T23:59:59.000Z

54

Positive modulator of bone morphogenic protein-2  

DOE Patents (OSTI)

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

Zamora, Paul O. (Gaithersburg, MD); Pena, Louis A. (Poquott, NY); Lin, Xinhua (Plainview, NY); Takahashi, Kazuyuki (Germantown, MD)

2009-01-27T23:59:59.000Z

55

6Bone Backbone Routing Guidelines  

Science Conference Proceedings (OSTI)

The 6Bone is an Ipv6 testbed to assist in the evolution and deployment of IPv6. Because of this, it is important that the core backbone of the IPv6 network maintain stability, and that all operators have a common set of rules and guidelines by which ...

R. Rockell; R. Fink

2000-02-01T23:59:59.000Z

56

Insight in the Organic-Mineral Interface Structure of Intact Human ...  

Science Conference Proceedings (OSTI)

Here, we will present our recent results on a solid state NMR investigation of the structure of the organic-mineral interface in intact human bone samples.

57

Consistent 4D cortical thickness measurement for longitudinal neuroimaging study  

Science Conference Proceedings (OSTI)

Accurate and reliable method for measuring the thickness of human cerebral cortex provides powerful tool for diagnosing and studying of a variety of neuro-degenerative and psychiatric disorders. In these studies, capturing the subtle longitudinal changes ...

Yang Li; Yaping Wang; Zhong Xue; Feng Shi; Weili Lin; Dinggang Shen

2010-09-01T23:59:59.000Z

58

Generic-model based human-body modeling  

Science Conference Proceedings (OSTI)

This paper presents a generic-model based human-body modeling method which take the anatomical structure of the human body into account. The generic model contains anatomical structure of bones and muscles of the human body. For a given target skin mesh, ... Keywords: anatomically-based modeling, generic model, human body modeling

Xiaomao Wu; Lizhuang Ma; Ke-Sen Huang; Yan Gao; Zhihua Chen

2005-09-01T23:59:59.000Z

59

Digital electronic bone growth stimulator  

DOE Patents (OSTI)

The present invention relates to the electrical treatment of biological tissue. In particular, the present invention discloses a device that produces discrete electrical pulse trains for treating osteoporosis and accelerating bone growth. According to its major aspects and broadly stated, the present invention consists of an electrical circuit configuration capable of generating Bassett-type waveforms shown with alternative signals provide for the treatment of either fractured bones or osteoporosis. The signal generator comprises a quartz clock, an oscillator circuit, a binary divider chain, and a plurality of simple, digital logic gates. Signals are delivered efficiently, with little or no distortion, and uniformly distributed throughout the area of injury. Perferably, power is furnished by widely available and inexpensive radio batteries, needing replacement only once in several days. The present invention can be affixed to a medical cast without a great increase in either weight or bulk. Also, the disclosed stimulator can be used to treat osteoporosis or to strengthen a healing bone after the cast has been removed by attaching the device to the patient`s skin or clothing.

Kronberg, J.W.

1993-01-01T23:59:59.000Z

60

Cerebral Cortex doi:10.1093/cercor/bhi116 Temporary Occlusion of Associative Motor Cortical Plasticity by Prior Dynamic Motor Training  

E-Print Network (OSTI)

A novel Hebbian stimulation paradigm was employed to examine physiological correlates of motor memory formation in humans. Repetitive pairing of median nerve stimulation with transcranial magnetic stimulation over the contralateral motor cortex (paired associative stimulation, PAS) may decrease human motor cortical excitability at interstimulus intervals of 10 ms (PAS10) or increase excitability at 25 ms (PAS25). The properties of this plasticity have previously been shown to resemble associative timing-dependent long-term depression (LTD) and long-term potentiation (LTP) as established in vitro. Immediately after training a novel dynamic motor task, the capacity of the motor cortex to undergo plasticity in response to PAS25 was abolished. PAS10-induced plasticity remained unchanged. When retested after 6 h, PAS25-induced plasticity recovered to baseline levels. After training, normal PAS25induced plasticity was observed in the contralateral training-naive

Katja Stefan; Matthias Wycislo; Reinhard Gentner; Axel Schramm; Markus Naumann; Karlheinz Reiners; Joseph Classen

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Profiling Heterogeneous Multi-GPU Systems to Accelerate Cortically Inspired Learning Algorithms  

E-Print Network (OSTI)

Profiling Heterogeneous Multi-GPU Systems to Accelerate Cortically Inspired Learning Algorithms Andrew Nere, Atif Hashmi, and Mikko Lipasti Department of Electrical and Computer Engineering University a plausible, attractive, fault-tolerant, and energy- efficient possibility. Such attributes have once again

Lipasti, Mikko H.

62

Genomic deletion of a long-range bone enhancer misregulatessclerostin in Van Buchem disease  

Science Conference Proceedings (OSTI)

Mutations in distant regulatory elements can negatively impact human development and health, yet due to the difficulty of detecting these critical sequences we predominantly focus on coding sequences for diagnostic purposes. We have undertaken a comparative sequence-based approach to characterize a large noncoding region deleted in patients affected by Van Buchem disease (VB), a severe sclerosing bone dysplasia. Using BAC recombination and transgenesis we characterized the expression of human sclerostin (sost) from normal (hSOSTwt) or Van Buchem(hSOSTvb D) alleles. Only the hSOSTwt allele faithfully expressed high levels of human sost in the adult bone and impacted bone metabolism, consistent with the model that the VB noncoding deletion removes a sost specific regulatory element. By exploiting cross-species sequence comparisons with in vitro and in vivo enhancer assays we were able to identify a candidate enhancer element that drives human sost expression in osteoblast-like cell lines in vitro and in the skeletal anlage of the E14.5 mouse embryo, and discovered a novel function for sclerostin during limb development. Our approach represents a framework for characterizing distant regulatory elements associated with abnormal human phenotypes.

Loots, Gabriela G.; Kneissel, Michaela; Keller, Hansjoerg; Baptist, Myma; Chang, Jessie; Collette, Nicole M.; Ovcharenko, Dmitriy; Plajzer-Frick, Ingrid; Rubin, Edward M.

2005-04-15T23:59:59.000Z

63

Molecular and ultrastructural changes in human bone with ...  

Science Conference Proceedings (OSTI)

Microbial synthesis and fabrication of palladium nanoparticle catalysts by using the metal ion-reducing bacterium Shewanella algae · Micromechanical ...

64

The cortical organization of audio-visual sentence comprehension: an fMRI study at 4 Tesla  

E-Print Network (OSTI)

The cortical organization of audio-visual sentence comprehension: an fMRI study at 4 Tesla Cheryl M Tesla. Participants viewed the face and upper body of a speaker via a video screen while listening

65

Effects of glucocorticoid treatment on bone strength  

Science Conference Proceedings (OSTI)

gene results in the autosomal dominant high-bone-mass trait. Am. J Hum Genet 70:11–19. 33. Dubrow SA, Hruby PM, Akhter MP (2007) Gender specific LRP5.

66

Microdamage accumulation in bovine trabecular bone  

E-Print Network (OSTI)

When bone is loaded beyond its failure point, it develops damage in the form of microcracks. Normally, microcracks are repaired by the remodeling process, limiting the number of in vivo microcracks. However, if the rate ...

Moore, Tara L. Arthur (Tara Lee Arthur), 1972-

2001-01-01T23:59:59.000Z

67

Effects of deuterium oxide and galvanic vestibular stimulation on visual cortical cell function  

SciTech Connect

The spontaneous and evoked unit activities of complex visual cortical cells were recorded from Brodmann's area 18 in immobilized, unanesthetized cats before, during, and after stimulation of the vestibular system. The vestibular system was stimulated by intravenous injection of deuterium oxide (D2O)--a noted nystagmogenic agent--or by direct galvanic stimulation of the labyrinth. Measures of the receptive-field areas, poststimulus time histograms, directional preferences, and the optimal speed of the light bar stimulating the cell were obtained before and after the application of D2O. Directional preferences were determined in a novel manner, using a method derived from a hierarchical clustering technique. Data were collected and analyzed from a) visual cortical cells in cats with intact labyrinths, b) visual cortical cells in cats following bilateral labrinthectomies, and c) nonvisual cortical cells in cats with intact labyrinths. The other cellular characteristics were also altered by the D2O. Galvanic stimulation of the labyrinth resembles, in its effects, the injection of D2O. In labyrinth-intact cats, the time course of area 18 spontaneous activity dramatically increased 30 min or more after D2O was administered. It peaked 2-3 h later and still had not returned to preinjection levels even 7 h after the D2O administration. In bilaterally labyrinthectomized cats, the spontaneous activity of the visual cells did not change following D2O administration. In nonvisual cells from labyrinth-intact cats, the spontaneous activity demonstrated a slight but significant decrease over time after D2O injection. In pilot studies, the cats were injected with D2O. Within 8-10 min afterward, signs of positional nystagmus commenced; and within 30 min, problems in maintaining balance were noted. This continued for 7-8 h before disappearing. In the labyrinthectomized animals, such effects were not observed.

Reinis, S.; Landolt, J.P.; Weiss, D.S.; Money, K.E.

1984-03-01T23:59:59.000Z

68

Predicting stimulus-locked single unit spiking from cortical local field potentials  

Science Conference Proceedings (OSTI)

The rapidly increasing use of the local field potential (LFP) has motivated research to better understand its relation to the gold standard of neural activity, single unit (SU) spiking. We addressed this in an in vivo, awake, restrained mouse ... Keywords: A1, Auditory cortex, Bayesian algorithm, Beta band, Despiking, EEG, Electroencephalography, Evoked potentials, Gamma band, Hilbert transform, LFP, Oscillation, Phase, Single cortical cells, Spike prediction, Theta band

Edgar E. Galindo-Leon; Robert C. Liu

2010-12-01T23:59:59.000Z

69

A minimal model of plasma membrane heterogeneity requires coupling cortical actin to criticality  

E-Print Network (OSTI)

We present a minimal model of plasma membrane heterogeneity that combines criticality with connectivity to cortical cytoskeleton. Our model is motivated by recent observations of micron-sized critical fluctuations in plasma membrane vesicles that are detached from their cortical cytoskeleton. We incorporate criticality using a conserved order parameter Ising model coupled to a simple actin cytoskeleton interacting through point-like pinning sites. Using this minimal model, we recapitulate several experimental observations of plasma membrane raft heterogeneity. Small (r~20nm) and dynamic fluctuations at physiological temperatures arise from criticality. Including connectivity to cortical cytoskeleton disrupts large fluctuations, prevents macroscopic phase separation at low temperatures (T<=22{\\deg}C), and provides a template for long lived fluctuations at physiological temperature (T=37{\\deg}C). Cytoskeleton-stabilized fluctuations produce significant barriers to the diffusion of some membrane components in a manner that is weakly dependent on the number of pinning sites and strongly dependent on criticality. More generally, we demonstrate that critical fluctuations provide a physical mechanism to organize and spatially segregate membrane components by providing channels for interaction over large distances.

Benjamin B. Machta; Stefanos Papanikolaou; James P. Sethna; Sarah L. Veatch

2010-09-10T23:59:59.000Z

70

Cellular and molecular immunotherapeutics derived from the bone marrow stroma  

E-Print Network (OSTI)

The bone marrow contains a multipotent stromal cell, commonly referred to as a mesenchymal stem cell (MSC). There has been recent interest in the clinical use of MSCs for cell-based therapy because: (1) bone marrow aspiration ...

Parekkadan, Biju

2008-01-01T23:59:59.000Z

71

Orthopaedic tissue engineering and bone regeneration  

Science Conference Proceedings (OSTI)

Orthopaedic tissue engineering combines the application of scaffold materials, cells and the release of growth factors. It has been described as the science of persuading the body to reconstitute or repair tissues that have failed to regenerate or heal ... Keywords: Bone, biodegradable polymers, biomaterials, cell therapy, fracture repair, orthopaedics, tissue engineering

Glenn Dickson; Fraser Buchanan; David Marsh; Eileen Harkin-Jones; Uel Little; Mervyn McCaigue

2007-01-01T23:59:59.000Z

72

A model for the orientational ordering of the plant microtubule cortical array  

E-Print Network (OSTI)

The plant microtubule cortical array is a striking feature of all growing plant cells. It consists of a more or less homogeneously distributed array of highly aligned microtubules connected to the inner side of the plasma membrane and oriented transversely to the cell growth axis. Here we formulate a continuum model to describe the origin of orientational order in such confined arrays of dynamical microtubules. The model is based on recent experimental observations that show that a growing cortical microtubule can interact through angle dependent collisions with pre-existing microtubules that can lead either to co-alignment of the growth, retraction through catastrophe induction or crossing over the encountered microtubule. We identify a single control parameter, which is fully determined by the nucleation rate and intrinsic dynamics of individual microtubules. We solve the model analytically in the stationary isotropic phase, discuss the limits of stability of this isotropic phase, and explicitly solve for the ordered stationary states in a simplified version of the model.

Rhoda J. Hawkins; Simon H. Tindemans; Bela M. Mulder

2009-05-20T23:59:59.000Z

73

Modeling aspects of human memory for scientific study.  

Science Conference Proceedings (OSTI)

Working with leading experts in the field of cognitive neuroscience and computational intelligence, SNL has developed a computational architecture that represents neurocognitive mechanisms associated with how humans remember experiences in their past. The architecture represents how knowledge is organized and updated through information from individual experiences (episodes) via the cortical-hippocampal declarative memory system. We compared the simulated behavioral characteristics with those of humans measured under well established experimental standards, controlling for unmodeled aspects of human processing, such as perception. We used this knowledge to create robust simulations of & human memory behaviors that should help move the scientific community closer to understanding how humans remember information. These behaviors were experimentally validated against actual human subjects, which was published. An important outcome of the validation process will be the joining of specific experimental testing procedures from the field of neuroscience with computational representations from the field of cognitive modeling and simulation.

Caudell, Thomas P. (University of New Mexico); Watson, Patrick (University of Illinois - Champaign-Urbana Beckman Institute); McDaniel, Mark A. (Washington University); Eichenbaum, Howard B. (Boston University); Cohen, Neal J. (University of Illinois - Champaign-Urbana Beckman Institute); Vineyard, Craig Michael; Taylor, Shawn Ellis; Bernard, Michael Lewis; Morrow, James Dan; Verzi, Stephen J.

2009-10-01T23:59:59.000Z

74

Celebrating Black History Month with DOE's Sheri Bone | Department of  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

with DOE's Sheri Bone with DOE's Sheri Bone Celebrating Black History Month with DOE's Sheri Bone February 9, 2011 - 2:04pm Addthis Sheri Bone. | File photo. Sheri Bone. | File photo. Ebony Meeks Former Assistant Press Secretary, Office of Public Affairs Throughout the month of February, we're introducing some remarkable African Americans who are working to advance the President's clean energy agenda and help the Department of Energy achieve its mission. This week we're profiling Sheri Bone who is Senior Project Director, Office of Nuclear Materials Integration, National Nuclear Security Administration. Sheri Bone Question: What is your key responsibility? SB: I'm responsible for developing the Department of Energy's strategic plan for nuclear materials. This means directing and leading a team of

75

Receptive field self-organization in a model of the fine structure in v1 cortical columns  

Science Conference Proceedings (OSTI)

We study a dynamical model of processing and learning in the visual cortex, which reflects the anatomy of V1 cortical columns and properties of their neuronal receptive fields. Based on recent results on the fine-scale structure of columns in V1, we ...

Jörg Lücke

2009-10-01T23:59:59.000Z

76

Sensory information in local field potentials and spikes from visual and auditory cortices: time scales and frequency bands  

Science Conference Proceedings (OSTI)

Studies analyzing sensory cortical processing or trying to decode brain activity often rely on a combination of different electrophysiological signals, such as local field potentials (LFPs) and spiking activity. Understanding the relation between these ... Keywords: Audition, Firing rates, Information theory, Oscillations, Population coding, Vision

Andrei Belitski; Stefano Panzeri; Cesare Magri; Nikos K. Logothetis; Christoph Kayser

2010-12-01T23:59:59.000Z

77

On nano size structures for enhanced bone formation.  

E-Print Network (OSTI)

??Purpose The general aim of the present thesis was to investigate early bone response to titanium implants modified with nano size structures. Therefore, 1. a… (more)

Meirelles, Luiz

2007-01-01T23:59:59.000Z

78

Bone scanning in the detection of occult fractures  

SciTech Connect

The potential role of bone scanning in the early detection of occult fractures following acute trauma was investigated. Technetium 99m pyrophosphate bone scans were obtained in patients with major clinical findings and negative or equivocal roentgenograms following trauma. Bone scanning facilitated the prompt diagnosis of occult fractures in the hip, knee, wrist, ribs and costochondral junctions, sternum, vertebrae, sacrum, and coccyx. Several illustrative cases are presented. Roentgenographic confirmation occurred following a delay of days to weeks and, in some instances, the roentgenographic findings were subtle and could be easily overlooked. This study demonstrates bone scanning to be invaluable and definitive in the prompt detection of occult fractures.

Batillas, J.; Vasilas, A.; Pizzi, W.F.; Gokcebay, T.

1981-07-01T23:59:59.000Z

79

Directed Bone Regeneration to Prevent Fatigue Failure of  

Science Conference Proceedings (OSTI)

... given for OC-Implants used as artifical bone grafts. Results include macro radiographs, CAT scans, and microscpic and SEM evaluation of recovered sections.

80

Adapting the polycarbonate dosimeter and electrochemical etching to the microdosimetry of /sup 239/Pu in bone  

SciTech Connect

The problem of setting the maximum permissible body burden, MPBB, for /sup 239/Pu is a complex one. Recent papers have been published which favor lowering the MPBB by varying factors depending on the assumptions used. /sup 239/Pu has been shown quite clearly, on detailed autoradiograph, to concentrate on the trabecular surfaces of the endosteal face of osseous tissue. This realization led the ICRP to propose the alteration of the MPBB for /sup 239/Pu in a manner based upon microdosimetry of /sup 239/Pu in bone, i.e., determine the dose out to 10..mu..m from the bone surfaces. Unfortunately, microdosimetry fulfilling this requirement has not been available. We are working toward this objective utilizing the Lexan polycarbonate detector and our optimized electrochemical etching procedure to amplify plutonium alpha tracks. As a prerequisite to this work, we are studying three problems inherently present in the Lexan detector. They involve achieving a very low background of tracks on the foils and a high degree of reproducibility between etching batches at this background level. Thirdly, we are determining the factor by which to multiply the number of induced tracks/cm/sup 2/ (..cap alpha.. and recoil) to obtain dose equivalent (rem). In this calibration we are using a standard /sup 239/Pu source and a surface barrier detection system. The plutonium bearing bones used in the microdosimetry phase of this research are rat, dog, and human.

Stillwagon, G.B.; Su, S.J.; Morgan, K.Z.

1977-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

On-off intermittency of thalamo-cortical oscillations in the electroencephalogram of rats with genetic predisposition to absence epilepsy  

E-Print Network (OSTI)

Spike-wave discharges (SWD) are electroencephalographic hallmarks of absence epilepsy. SWD are known to originate from thalamo-cortical neuronal network that normally produce sleep spindle oscillations. Although both sleep spindles and SWD are considered as thalamo-cortical oscillations, functional relationship between them is still uncertain. The present study describes temporal dynamics of SWD and sleep spindles as determined in long-term EEG recordings in WAG/Rij rat model of absence epilepsy. It was found that non-linear dynamics of SWD fits well to the law of 'on-off intermittency'. Typical sleep spindles that occur during slow-wave sleep (SWS) also demonstrated 'on-off intermittency' behavior, in contrast to high-voltage spindles during intermediate sleep stage, whose dynamics was uncertain. This implies that both SWS sleep spindles and SWD are controlled by a system-level mechanism that is responsible for regulating circadian activity and/or sleep-wake transitions.

Evgenia Sitnikova; Alexander E. Hramov; Alexey A. Ovchinnikov; Alexey A. Koronovskii

2013-02-17T23:59:59.000Z

82

Hazards Associated with the Use of Bone Ash in Contact with Molten ...  

Science Conference Proceedings (OSTI)

Bone ash itself is non-toxic and environmentally benign. However recent evidence indicates that bone ash can be reduced upon contact with aluminum alloys to ...

83

Differences in Bone Quality between High versus Low Turnover Renal Osteodystrophy  

SciTech Connect

Abnormal bone turnover is common in chronic kidney disease (CKD), but its effects on bone quality remain unclear. This study sought to quantify the relationship between abnormal bone turnover and bone quality. Iliac crest bone biopsies were obtained from CKD-5 patients on dialysis with low (n=18) or high (n=17) turnover, and from volunteers (n=12) with normal turnover and normal kidney function. Histomorphometric methods were used to quantify the microstructural parameters; Fourier transform infrared spectroscopy and nanoindentation were used to quantify the material and mechanical properties in bone. Reduced mineral-to-matrix ratio, mineral crystal size, stiffness and hardness were observed in bone with high turnover compared to bone with normal or low turnover. Decreased cancellous bone volume and trabecular thickness were seen in bone with low turnover compared to bone with normal or high turnover. Bone quality, as defined by its microstructural, material, and mechanical properties, is related to bone turnover. These data suggest that turnover related alterations in bone quality may contribute to the known diminished mechanical competence of bone in CKD patients, albeit from different mechanisms for bone with high (material abnormality) vs. low (microstructural alteration) turnover. The present findings suggest that improved treatments for renal osteodystrophy should seek to avoid low or high bone turnover and aim for turnover rates as close to normal as possible.

Porter, Daniel S. [University of Kentucky, Lexington; Pienkowski, David [University of Kentucky, Lexington; Faugere, Marie-Claude [Albert B. Chandler Medical Center; Malluche, Hartmut H. [Albert B. Chandler Medical Center

2012-01-01T23:59:59.000Z

84

Relation between hydrogen isotopic ratios of bone collagen and rain  

Science Conference Proceedings (OSTI)

The hydrogen isotopic value ([delta]D) of deer bone collagen is related to both [delta]D of rain during the growing season and growing season relative humidity (RH). With correction for the effects of RH, bone [delta]D is related to growing season rain [delta]D in a simple manner with a slope of 1.0. This indicates that, with RH correction, there are no additional sources of bias in the [delta]D of bone due to unaccounted for biologic or climatic effects. Due to a low sensitivity of bone [delta]D to RH effects, both yearly and growing season rain [delta]D can be estimated with considerable accuracy (R = 0.97 and R = 0.96) from bone collagen [delta]D and [delta][sup 15]N. Here, [delta][sup 15]N is used to correct bone [delta]D for the effects of RH. From these estimates of rain [delta]D, it may then be possible to evaluate temperature since the [delta]D of rain primarily reflects local temperature. Therefore, the measurement of bone collagen [delta]D has good potential for evaluating paleoclimates.

Cormie, A.B.; Schwarcz, H.P. (McMaster Univ., Hamilton, Ontario (Canada)); Gray, J. (Univ. of Alberta, Edmonton (Canada))

1994-01-01T23:59:59.000Z

85

Human Health  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Health Print E-mail Climate change can have a number of direct and indirect effects on human health. For example, rising temperatures can contribute to the number of deaths...

86

Remembering the past : multimodal imaging of cortical contributions to episodic retrieval  

E-Print Network (OSTI)

What is the nature of the neural processes that allow humans to remember past events? The theoretical framework adopted in this thesis builds upon cognitive models that suggest that episodic retrieval can be decomposed ...

Kahn, Itamar

2005-01-01T23:59:59.000Z

87

On the mechanistic origins of toughness in bone  

Science Conference Proceedings (OSTI)

One of the most intriguing protein materials found in Nature is bone, a material composed out of assemblies of tropocollagen molecules and tiny hydroxyapatite mineral crystals, forming an extremely tough, yet lightweight, adaptive and multi-functional material. Bone has evolved to provide structural support to organisms, and therefore, its mechanical properties are of great physiological relevance. In this article, we review the structure and properties of bone, focusing on mechanical deformation and fracture behavior from the perspective of the multi-dimensional hierarchical nature of its structure. In fact, bone derives its resistance to fracture with a multitude of deformation and toughening mechanisms at many of these size-scales, ranging from the nanoscale structure of its protein molecules to its macroscopic physiological scale.

Launey, Maximilien E.; Buehler, Markus J.; Ritchie, Robert O.

2009-10-07T23:59:59.000Z

88

Resection followed by vascularized bone autograft in patients with possible recurrence of malignant bone tumors after conservative treatment  

SciTech Connect

In conservative treatment of malignant bone tumors, assessment of the local condition is difficult. The radiological changes seen in the irradiated tumor and the frequent occurrence of pathological fractures at this site may give rise to the fear that the tumor has relapsed. Resection of the whole of the involved bone is the best way to assure adequate local control but the extent of the bone defect and the bad local conditions secondary to irradiation make reconstruction hazardous. In two patients (one with Ewing's sarcoma of the femur and one with osteogenic sarcoma of the humerus) the authors used a free, vascularized fibular graft for the reconstruction having obtained consolidation of the limb after resection of the irradiated tumor, with preservation of its function. The encouraging results obtained have suggested a conservative attitude as primary treatment of specific malignant bone tumors.

Metaizeau, J.P.; Olive, D.; Bey, P.; Bordigoni, P.; Plenat, F.; Prevot, J.

1984-04-01T23:59:59.000Z

89

X-band EPR imaging as a tool for gradient dose reconstruction in irradiated bones  

SciTech Connect

Purpose: Various tools are currently available for dose reconstruction in individuals after accidental exposure to ionizing radiation. Among the available biological analyses, Monte Carlo simulations, and biophysical methods, such as electron paramagnetic resonance (EPR), the latter has proved its usefulness for retrospective dosimetry. Although EPR spectroscopy is probably the most sensitive technique, it does not provide spatial dosimetric data. This information is, however, highly desirable when steep dose gradient irradiations are involved. The purpose of this work was to explore the possibilities of EPR imaging (EPRI) for spatial dose reconstruction in irradiated biological material. Methods: X-band EPRI was used to reconstruct ex vivo the relative dose distribution in human bone samples and hydroxyapatite phantoms after irradiation with brachytherapy seeds or x rays. Three situations were investigated: Homogeneous, stepwise gradient, and continuous gradient irradiation. Results: EPRI gave a faithful relative spin density distribution in bone samples and in hydroxyapatite phantoms. Measured dose ratios were in close agreement with the actual delivered dose ratios. EPRI was able to distinguish the dose gradients induced by two different sources ({sup 125}I and {sup 192}Ir). However, the measured spatial resolution of the system was 1.9 mm and this appeared to be a limiting factor. The method could be improved by using new signal postprocessing strategies. Conclusions: This study demonstrates that EPRI can be used to assess the regional relative dose distribution in irradiated bone samples. The method is currently applicable to ex vivo measurements of small size samples with low variation in tissue density but is likely to be adapted for in vivo application using L-band EPRI.

Leveque, Philippe; Godechal, Quentin; Bol, Anne; Trompier, Francois; Gallez, Bernard [Biomedical Magnetic Resonance Unit, Universite catholique de Louvain, B-1200 Brussels (Belgium); Molecular Imaging and Experimental Radiotherapy Unit, Universite catholique de Louvain, B-1200 Brussels (Belgium); Institut de Surete Nucleaire et de Radioprotection, F-92262 Fontenay-aux-Roses (France); Biomedical Magnetic Resonance Unit, Universite catholique de Louvain, B-1200 Brussels (Belgium)

2009-09-15T23:59:59.000Z

90

The Arabidopsis TRM1TON1 Interaction Reveals a Recruitment Network Common to Plant Cortical  

E-Print Network (OSTI)

microtubules via its C-terminal TON1 interaction motif. Interestingly, three motifs of TRMs are found in CAP350, a human centrosomal protein interacting with FOP, and the C-terminal M2 motif of CAP350 is responsible., 2006). CAP350 has also been proposed to specifically stabilize Golgi-associated microtubules

Paris-Sud XI, Université de

91

Interacting cortical and basal ganglia networks underlying finding and tapping to the musical beat  

Science Conference Proceedings (OSTI)

Humans are able to find and tap to the beat of musical rhythms varying in complexity from children's songs to modern jazz. Musical beat has no one-to-one relationship with auditory features-it is an abstract perceptual representation that emerges from ...

Shu-Jen Kung; Joyce L. Chen; Robert J. Zatorre; Virginia B. Penhune

2013-03-01T23:59:59.000Z

92

Level of osteopenia and bone recovery in alcohol-fed adolescent rats  

E-Print Network (OSTI)

Adolescence is a period in human growth and development that is a time of rapid and drastic change. It is also known to be an age of widespread alcohol abuse. Studies addressing the reversibility of the deleterious effects of chronic alcohol consumption on young, actively growing adolescent bones have not been done. The objective of this study was to determine the level of bone recovery, if any, once an adolescent ceases alcohol consumption. Fifty, 4-week old, female, Sprague-Dawley rats were individually housed and maintained in an American Association for the Accreditation of Laboratory Animal Care-accredited facility at Texas A&M. The rats (n = 6 or 7 per group) were fed either alcohol (35% ethanol-derived calories), isocaloric liquid diet, or chow for 2 or 4 weeks, depending on the experimental group. The weekly blood alcohol concentrations averaged 309 [] 9 mg/dl. The rats were sacrificed 2 and 4 weeks after the experimental feeding began. The BioQuant Morphometric System was used to perform the histomorphometric analyses of the proximal tibia. Tibia bone volume per trabecular volume (BV/TV) in both age groups of alcohol and pair-fed animals was significantly less when compared to the chow 4 week animals. BV/TV was increased in the alcohol recovery group when compared to the alcohol 2 and 4 week groups, but the level of growth never reached the chow-fed 4 week group. Femur length, diameter and volume measurements increased in the alcohol recovery group when compared to both the alcohol 2 and 4 week groups. However, the length and volume parameters did not fully recover to equal those of the control chow 4 week animals, or even the some-age pair-fed animals. Femur diameter of the alcohol recovery animals was comparable to the alcohol 4 week animals, but less than the chow-fed. Alcohol also suppressed IGF-I levels. Full bone recovery did not occur within two weeks after removal of alcohol from the diet, suggesting the detrimental effects due to alcohol were not completely reversible during this time frame.

Spears, Heather Lynae

1999-01-01T23:59:59.000Z

93

Triple-phase bone image abnormalities in Lyme arthritis  

Science Conference Proceedings (OSTI)

Arthritis is a frequent manifestation of Lyme disease. Limited triple-phase Tc-99m MDP bone imaging of the wrists and hands with delayed whole-body images was performed in a patient with Lyme arthritis. This demonstrated abnormal joint uptake in the wrists and hands in all three phases, with increased activity seen in other affected joints on delayed whole-body images. These findings are nonspecific and have been previously described in a variety of rheumatologic conditions, but not in Lyme disease. Lyme disease should be considered in the differential diagnosis of articular and periarticular bone scan abnormalities.

Brown, S.J.; Dadparvar, S.; Slizofski, W.J.; Glab, L.B.; Burger, M. (Hahnemann Univ. Hospital, Philadelphia, PA (USA))

1989-10-01T23:59:59.000Z

94

Apatite-polymer composites for the controlled delivery of bone morphogenetic proteins  

E-Print Network (OSTI)

Current treatment of bone defects due to trauma, cancer, or degenerative spine diseases involves the implantation of a bone graft. Autografts, which are harvested from the patient's own body, are associated with problems ...

Yong, Tseh-Hwan

2005-01-01T23:59:59.000Z

95

Spatial scaling in human peripheral vision.  

E-Print Network (OSTI)

??The observation that performance in many visual tasks can be made independent of eccentricity by increasing the size of peripheral stimuli according to the cortical… (more)

Makela, Pia K.

1994-01-01T23:59:59.000Z

96

Alpha-tricalcium phosphate-calcium sulfate hybrid bone cement ...  

Science Conference Proceedings (OSTI)

Presentation Title, Alpha-tricalcium phosphate-calcium sulfate hybrid bone ... electron scanning microscopy on the characterization of polymer coating ... Improving the Resistance to Contact and Flexural Damage of Ceramics Using Elastic Gradients ... using phosphoric acid activation by ultrasound and microwave radiation ...

97

BoneMaster™ HA Coating – An In Vivo Assessment  

Science Conference Proceedings (OSTI)

... group (668 N) demonstrated significantly higher pull out strength than control PPS group (348 N). After 32 weeks, the pull out strength for BoneMaster HA and PPS groups ... Facilitates Neural Stem Cell Adhesion, Proliferation and Differentiation ... Sol-Gel Synthesis of Bio-Active Nanoporous Sodium Zirconate Coated on ...

98

The human thalamus is crucially involved in executive control operations  

Science Conference Proceedings (OSTI)

The processing of executive control is thought to involve cortical as well as thalamic brain areas. However, the questions of how thalamic structures contribute to the control of behavior and how cortical versus thalamic processing is coordinated remain ...

Frank Marzinzik; Michael Wahl; Gerd-Helge Schneider; Andreas Kupsch; Gabriel Curio; Fabian Klostermann

2008-10-01T23:59:59.000Z

99

Porous coatings from wire mesh for bone implants  

DOE Patents (OSTI)

A method of coating areas of bone implant elements and the resulting implant having a porous coating are described. Preselected surface areas are covered by a preform made from continuous woven lengths of wire. The preform is compressed and heated to assure that diffusion bonding occurs between the wire surfaces and between the surface boundaries of the implant element and the wire surfaces in contact with it. Porosity is achieved by control of the resulting voids between the bonded wire portions.

Sump, Kenneth R. (Richland, WA)

1986-01-01T23:59:59.000Z

100

Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Synchrotron  

NLE Websites -- All DOE Office Websites (Extended Search)

Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Synchrotron Imaging Archaeopteryx specimens are important but extremely rare fossils. Due to their possession of both reptilian (jaws with teeth, long bony tail) and avian (feathered wings) characters, Archaeopteryx has been crucial in the development of Darwinian evolution. Despite their importance, no Archaeopteryx specimen has ever been chemically analyzed. This in large part may be explained by the analytical obstacles which preclude applying standard methods to such valuable specimens; destructive sampling is not an option and most non-destructive methods cannot handle large specimens. Furthermore, mapping using conventional methods is far too slow to enable chemical zonation to be reasonably determined. Mapping of trace element chemistry is of tremendous interest, however, because it opens a window into understanding several critical questions about Archaeopteryx in particular, and about fossil specimens in general. Preserved trace chemistry in bones and soft tissue may be remnants of the living organism, and therefore may give insight into life processes of extinct organisms. When mapping includes the embedding rock matrix, mass transfer between the fossil and the matrix can be constrained, hence giving information about mode of preservation. Chemical analysis can also resolve artefacts of the curation process. Finally, accurate chemical maps can also be useful for directing future work by highlighting regions that may be promising for other types of analysis including structural methods (CT, diffraction) or techniques that use other parts of the electromagnetic spectrum (infra-red).

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone at the  

NLE Websites -- All DOE Office Websites (Extended Search)

3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone 3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone at the Nanoscale Scientists studying osteoporosis and other skeletal diseases are interested in the 3D structure of bone and its responses to conditions such as weightlessness, radiation (of particular interest to astronauts) and vitamin D deficiency. The current gold standard, micro-computed tomography (micro-CT), provides 3D images of trabeculae, the small interior struts of bone tissue, and electron microscopy can provide nanometer resolution of thin tissue slices. Hard X-ray transmission microscopy has provided the first 3D view of bone structure within individual trabeculae on the nanoscale. figure 1 Figure 1 Micro-CT (left) shows trabecular structure inside of bone. Transmission X-ray microscopy (TXM; center and right) can reveal localized details of osteocyte lacunae and their processes.

102

MICROSCOPIC METABOLISM OF CALCIUM IN BONE. III. MICRORADIOGRAPHIC MEASUREMENTS OF MINERAL DENSITY  

SciTech Connect

The range of microscopic calcium densities in man and in dog does not change wiih the age of the individual. The ranges, however. are not the same in the two species. New bone mineral in the dog is formed at higher density than similar mineral in man, and highly mineralized bone in the dog is more dense than the most dense bone in man. Thus species differcnces in calcium metabolism of bone do exist and should not be overlooked in the intercomparison of the uptake and retention of the alkaline earths in mammalian skeletons. (auth)

Rowland, R.E.; Jowsey, J.; Marshall, J.H.

1959-02-01T23:59:59.000Z

103

Bioactivation of myelotoxic xenobiotics by human neutrophil myeloperoxidase  

Science Conference Proceedings (OSTI)

Many environmental pollutants and drugs are toxic to the bone marrow. Some of these xenobiotics may initiate toxicity after undergoing bioactivation to free radicals and/or other reactive electrophiles. Peroxidases are a group of enzymes that catalyze the one-electron oxidative bioactivation of a variety of xenobiotics in vitro. Myeloperoxidase (MPO) is a peroxidative enzyme found in very high concentration in the neutrophils of human bone marrow. In this study, human MPO was evaluated to determine its ability to catalyze the in vitro bioactivation of known bone marrow toxicants that contain the aromatic hydroxyl (Ar-OH), aromatic amine (Ar-N-R{sub 2}), or heterocyclic tertiary amine ({double bond}N-R) moieties. The formation of free radical metabolites during the MPO-catalyzed bioactivation of hydroquinone and catechol (benzene metabolites), mitoxantrone and ametantrone (antitumor drugs), and chlorpromazine and promazine (antipsychotic drugs) was demonstrated by EPR spectroscopy. The reactivity of the products formed during the MPO catalyzed bioactivation of ({sup 14}C)hydroquinone and ({sup 14}C)catechol was shown by their covalent binding to protein and DNA in vitro. The covalently binding metabolite in each case is postulated to be the quinone form of the xenobiotic. In addition, both GSH and NADH were oxidized by the reactive intermediate(s) formed during the MPO-catalyzed bioactivation of many of the bone marrow toxicants tested. It was also shown that p,p-biphenol stimulated the MPO catalyzed bioactivation of both hydroquinone and catechol, while p-cresol stimulated the MPO-catalyzed bioactivation of catechol.

Roy, R.R.

1989-01-01T23:59:59.000Z

104

Cortical networks representing object categories and high-level attributes of familiar real-world action sounds  

Science Conference Proceedings (OSTI)

In contrast to visual object processing, relatively little is known about how the human brain processes everyday real-world sounds, transforming highly complex acoustic signals into representations of meaningful events or auditory objects. We recently ...

James W. Lewis; William J. Talkington; Aina Puce; Lauren R. Engel; Chris Frum

2011-08-01T23:59:59.000Z

105

Proton Range Uncertainty Due to Bone Cement Injected Into the Vertebra in Radiation Therapy Planning  

Science Conference Proceedings (OSTI)

We wanted to evaluate the influence of bone cement on the proton range and to derive a conversion factor predicting the range shift by correcting distorted computed tomography (CT) data as a reference to determine whether the correction is needed. Two CT datasets were obtained with and without a bone cement disk placed in a water phantom. Treatment planning was performed on a set of uncorrected CT images with the bone cement disk, and the verification plan was applied to the same set of CT images with an effective CT number for the bone cement disk. The effective CT number was determined by measuring the actual proton range with the bone cement disk. The effects of CT number, thicknesses, and position of bone cement on the proton range were evaluated in the treatment planning system (TPS) to draw a conversion factor predicting the range shift by correcting the CT number of bone cement. The effective CT number of bone cement was 260 Hounsfield units (HU). The calculated proton range for native CT data was significantly shorter than the measured proton range. However, the calculated range for the corrected CT data with the effective CT number coincided exactly with the measured range. The conversion factor was 209.6 [HU . cm/mm] for bone cement and predicted the range shift by approximately correcting the CT number. We found that the heterogeneity of bone cement could cause incorrect proton ranges in treatment plans using CT images. With an effective CT number of bone cement derived from the proton range and relative stopping power, a more actual proton range could be calculated in the TPS. The conversion factor could predict the necessity for CT data correction with sufficient accuracy.

Lim, Young Kyung [Department of Radiation Oncology, Institute of Health Sciences, Gyeongsang National University, Jinju (Korea, Republic of); Hwang, Ui-Jung [Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Shin, Dongho, E-mail: dongho@ncc.re.kr [Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Kim, Dong Wook [Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Kwak, Jungwon [Department of Radiation Oncology, Asan Medical Center, Seoul (Korea, Republic of); Yoon, Myonggeun; Lee, Doo Hyun; Lee, Se Byeong; Lee, Sang-Yeob [Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Park, Sung Yong [Department of Radiation Oncology, Samsung Medical Center, Seoul (Korea, Republic of); Pyo, Hong Ryeol [Department of Radiation Oncology, Institute of Health Sciences, Gyeongsang National University, Jinju (Korea, Republic of); Proton Therapy Center, National Cancer Center, Goyang, Gyeonggi (Korea, Republic of); Department of Radiation Oncology, Asan Medical Center, Seoul (Korea, Republic of); Department of Radiation Oncology, Samsung Medical Center, Seoul (Korea, Republic of)

2011-10-01T23:59:59.000Z

106

Fracture, bone mineral density, and the effects of calcitonin receptor ...  

Science Conference Proceedings (OSTI)

minus CTR isoform is expressed in essentially all human tissues known to .... duplicate error, and (3) Hardy–Weinberg equilibrium test p>0.001. Statistics.

107

6BONE pTLA and pNLA Formats (pTLA)  

Science Conference Proceedings (OSTI)

This memo defines how the 6bone uses the 3FFE::/16 IPv6 address prefix, allocated in RFC 2471, "IPv6 Testing Address Allocation", [6BONE-TLA], to create pseudo Top-Level Aggregation Identifiers (pTLA's) and pseudo Next-Level Aggregation Identifiers ...

B. Fink

2000-09-01T23:59:59.000Z

108

Multiple verification in complex biological systems: the bone remodelling case study  

Science Conference Proceedings (OSTI)

We present a set of formal techniques and a methodology for a composite formal analysis at the tissue and organ level, focusing on the verification of quantitative properties in the process of bone remodelling. Starting from a differential equation model, ... Keywords: bone remodelling, formal analysis, model checking, piecewise multi-affine abstraction, sensitivity

Ezio Bartocci; Pietro Liň; Emanuela Merelli; Nicola Paoletti

2012-01-01T23:59:59.000Z

109

Permian Bone Spring formation: Sandstone play in the Delaware basin. Part I - slope  

SciTech Connect

New exploration in the Permian (Leonardian) Bone Spring formation has indicated regional potential in several sandstone sections across portions of the northern Delaware basin. Significant production has been established in the first, second, and third Bone Spring sandstones, as well as in a new reservoir interval, the Avalon sandstone, above the first Bone Spring sandstone. These sandstones were deposited as submarine-fan systems within the northern Delaware basin during periods of lowered sea level. The Bone Spring as a whole consists of alternating carbonate and siliciclastic intervals representing the downdip equivalents to thick Abo-Yeso/Wichita-Clear Fork carbonate buildups along the Leonardian shelf margin. Hydrocarbon exploration in the Bone Spring has traditionally focused on debris-flow carbonate deposits restricted to the paleoslope. Submarine-fan systems, in contrast, extend a considerable distance basinward of these deposits and have been recently proven productive as much as 40-48 km south of the carbonate trend.

Montgomery, S.L. [Petroleum Consultant, Seattle, WA (United States)

1997-08-01T23:59:59.000Z

110

Human-machine interactions  

DOE Patents (OSTI)

Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

Forsythe, J. Chris (Sandia Park, NM); Xavier, Patrick G. (Albuquerque, NM); Abbott, Robert G. (Albuquerque, NM); Brannon, Nathan G. (Albuquerque, NM); Bernard, Michael L. (Tijeras, NM); Speed, Ann E. (Albuquerque, NM)

2009-04-28T23:59:59.000Z

111

ORISE: Protecting Human Subjects  

NLE Websites -- All DOE Office Websites (Extended Search)

Subjects Protecting Human Subjects The U.S. Department of Energy (DOE) Human Subjects Research Program exists to ensure that all research conducted at DOE institutions, whether...

112

Human Measure and Architecting  

E-Print Network (OSTI)

This book bundles the human measure and architecting articles. The articles address the relationship between product creation and humans and the role of the system architect.

Gerrit Muller

2002-01-01T23:59:59.000Z

113

Articular human joint modelling  

Science Conference Proceedings (OSTI)

The work reported in this paper encapsulates the theories and algorithms developed to drive the core analysis modules of the software which has been developed to model a musculoskeletal structure of anatomic joints. Due to local bone surface and contact ... Keywords: 6DOF, Joint Modelling, Software, Tissue wrapping, bilateral, constraints, forced contact based articulation, unilateral

Ibrahim i. Esat; Neviman Ozada

2010-03-01T23:59:59.000Z

114

Cortical dynamics of navigation and steering in natural scenes: Motion-based object segmentation, heading, and obstacle avoidance  

Science Conference Proceedings (OSTI)

Visually guided navigation through a cluttered natural scene is a challenging problem that animals and humans accomplish with ease. The ViSTARS neural model proposes how primates use motion information to segment objects and determine heading for purposes ... Keywords: MST, MT, Motion segmentation, Navigation, Object tracking, Optic flow, Steering

N. Andrew Browning; Stephen Grossberg; Ennio Mingolla

2009-12-01T23:59:59.000Z

115

Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells  

Science Conference Proceedings (OSTI)

Mesenchymal stem cells (MSC) from mouse bone marrow were shown to adopt a pancreatic endocrine phenotype in vitro and to reverse diabetes in an animal model. MSC from human bone marrow and adipose tissue represent very similar cell populations with comparable phenotypes. Adipose tissue is abundant and easily accessible and could thus also harbor cells with the potential to differentiate in insulin producing cells. We isolated human adipose tissue-derived MSC from four healthy donors. During the proliferation period, the cells expressed the stem cell markers nestin, ABCG2, SCF, Thy-1 as well as the pancreatic endocrine transcription factor Isl-1. The cells were induced to differentiate into a pancreatic endocrine phenotype by defined culture conditions within 3 days. Using quantitative PCR a down-regulation of ABCG2 and up-regulation of pancreatic developmental transcription factors Isl-1, Ipf-1, and Ngn3 were observed together with induction of the islet hormones insulin, glucagon, and somatostatin.

Timper, Katharina [Department of Research, University Hospital, Basel (Switzerland); Seboek, Dalma [Department of Research, University Hospital, Basel (Switzerland); Eberhardt, Michael [Department of Research, University Hospital, Basel (Switzerland); Linscheid, Philippe [Department of Research, University Hospital, Basel (Switzerland); Christ-Crain, Mirjam [Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland); Keller, Ulrich [Department of Research, University Hospital, Basel (Switzerland); Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland); Mueller, Beat [Department of Research, University Hospital, Basel (Switzerland); Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland); Zulewski, Henryk [Department of Research, University Hospital, Basel (Switzerland) and Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel (Switzerland)]. E-mail: henryk.zulewski@unibas.ch

2006-03-24T23:59:59.000Z

116

Human Performance - Fossil Operations  

Science Conference Proceedings (OSTI)

All humans make errors. Industrial human errors can result in a loss of life and can significantly impact the productivity and cost effectiveness of any facility or company. Several industries in which human error has had a significant impact (for example, airline, medical, military, nuclear power, aviation, and chemical) have implemented human performance programs with excellent results. Human errors by fossil plant operators can easily challenge plant safety and production. In the fossil operations are...

2007-02-28T23:59:59.000Z

117

Bone dielectric property variation as a function of mineralization at microwave frequencies  

Science Conference Proceedings (OSTI)

A critical need exists for new imaging tools to more accurately characterize bone quality beyond the conventional modalities of dual energy X-ray absorptiometry (DXA), ultrasound speed of sound, and broadband attenuation measurements. In this paper we ...

Paul M. Meaney; Tian Zhou; Douglas Goodwin; Amir Golnabi; Elia A. Attardo; Keith D. Paulsen

2012-01-01T23:59:59.000Z

118

Non-invasive shock wave stimulated periosteum for bone tissue engineering  

E-Print Network (OSTI)

The cambium cells of the periosteum, which are known osteoprogenitor cells, have limited suitability for clinical applications of bone tissue engineering due to their low cell number (2-5 cells thick). Extracorporeal shock ...

Kearney, Cathal (Cathal John)

2011-01-01T23:59:59.000Z

119

Geek-Up[6.10.2011]: Thermoelectrics' Great Power, Key Ingredient in Bone's  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

10.2011]: Thermoelectrics' Great Power, Key Ingredient in 10.2011]: Thermoelectrics' Great Power, Key Ingredient in Bone's Nanostructure Geek-Up[6.10.2011]: Thermoelectrics' Great Power, Key Ingredient in Bone's Nanostructure June 10, 2011 - 5:07pm Addthis Data image on lead telluride thermal conductivity | Photo Courtesy of Oak Ridge National Laboratory Data image on lead telluride thermal conductivity | Photo Courtesy of Oak Ridge National Laboratory Niketa Kumar Niketa Kumar Public Affairs Specialist, Office of Public Affairs What does this mean for me? Identifying a key ingredient in bone's nanostructure may help treat and prevent bone diseases such as osteoporosis and develop new light-weight, high-strength materials for innovative technologies. Advanced thermoelectric materials could be used to develop vehicle

120

Investigation of bone response to implant materials by electron microscopy and computer simulation  

E-Print Network (OSTI)

(cont.) implementation of this scintigraphic method for quantitative studies of osteoblast-mediated mineralization in vitro. A 2-D truss finite element model is used to study the remodeling of trabecular bone. Using strain ...

Wang, Hao, 1974-

2004-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Advances in Conjugated Linoleic Acid Research, Vol 2Chapter 13 CLA and Bone Modeling in Rats  

Science Conference Proceedings (OSTI)

Advances in Conjugated Linoleic Acid Research, Vol 2 Chapter 13 CLA and Bone Modeling in Rats Health Nutrition Biochemistry eChapters Health - Nutrition - Biochemistry AOCS Press Downloadable pdf of Chapter 13 C

122

Revised estimates of electron absorbed fractions and radionuclide S-values in trabecular bone  

E-Print Network (OSTI)

The field of nuclear medicine has reached advanced stages in the use of radiopharmaceuticals for the treatment and diagnosis of innumerable maladies. However, along with the use of nuclear medicine come responsibilities inherently associated with the use of radioactive material. It is necessary to be able to calculate doses in the trabecular bone region accurately and consistently. The accurate assessment of patient dose will allow physicians to better predict the amounts of radioactivity needed for specific diagnostic and therapeutic applications. Additionally, improved calculational techniques for bone dosimetry will decrease the likelihood of overadministrations and will allow for reliable predictions of side-effects to patients. The dosimetry of this region is therefore a very important, and unfortunately complicated, area associated with the field of nuclear medicine. A new dosimetric trabecular bone model has been developed and incorporated into a Monte Carlo radiation transport code to determine electron absorbed fractions in red bone marrow and the endosteal tissue which is contained in trabecular bone. The model is based on measured omnidirectional chord length distributions through trabeculae and marrow cavities in nine skeletal locations. Absorbed fractions were calculated for the two target regions, and then estimated from these results for all other skeletal regions thought to contain red marrow. These absorbed fractions were then used to calculate S-values for a variety of beta-emitting radionuclides at each of 15 skeletal locations thought to contain red bone marrow. Absorbed fractions and S-values were calculated for sources in the marrow, on the bone surface, and in the bone volume. Comparisons were made between the new absorbed fractions and those published in ICRP Publication 30, as well as between the new S-values and those determined from the MIRDOSE2 software.

Parry, Robert Alan

1995-01-01T23:59:59.000Z

123

Human Rights and Security  

E-Print Network (OSTI)

Migration, Human Rights and Security in Europe MRU Student Conference Proceedings 2012 Edited by Siril Berglund, Helen McCarthy and Agata Patyna #12;2 "Migration, Human Rights and Security...............................................................................................58 #12;3 "Migration, Human Rights and Security in Europe", MRU Student Conference Proceedings

Saunders, Mark

124

ORISE: Human Subjects Protection  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Subjects Protection Human Subjects Protection The Oak Ridge Institute for Science and Education (ORISE) performs technical assessments to assist U.S. Department of Energy (DOE) laboratories involved in human subjects research projects. Under DOE Order and Policy 443.1A, Protection of Human Subjects, and 10 CFR 745, DOE employees and contractors are expected to protect the rights and welfare of human research subjects. In support of the DOE Office of Science and the Human Subjects Protection Program (HSPP), ORISE has most recently assisted with the development and distribution of tools to address classified research and to track potential human social cultural behavior systems (HSCB) research conducted by DOE laboratories. Examples of products that ORISE has developed in support of the HSPP

125

The Deep-Sea Natural Products, Biogenic Polyphosphate (Bio-PolyP) and Biogenic Silica (Bio-Silica), as Biomimetic Scaffolds for Bone Tissue Engineering: Fabrication of a Morphogenetically-Active Polymer  

E-Print Network (OSTI)

Abstract: Bone defects in human, caused by fractures/nonunions or trauma, gain increasing impact and have become a medical challenge in the present-day aging population. Frequently, those fractures require surgical intervention which ideally relies on autografts or suboptimally on allografts. Therefore, it is pressing and likewise challenging to develop bone substitution materials to heal bone defects. During the differentiation of osteoblasts from their mesenchymal progenitor/stem cells and of osteoclasts from their hemopoietic precursor cells, a lineage-specific release of growth factors and a trans-lineage homeostatic cross-talk via signaling molecules take place. Hence, the major hurdle is to fabricate a template that is functioning in a way mimicking the morphogenetic, inductive role(s) of the native extracellular matrix. In the last few years, two naturally occurring polymers that are produced by deep-sea sponges, the biogenic polyphosphate (bio-polyP) and biogenic silica (bio-silica) have also been identified as promoting morphogenetic on both osteoblasts andMar. Drugs 2013, 11 719

Xiaohong Wang; Heinz C. Schröder; Qingling Feng; Florian Draenert; Werner E. G. Müller

2013-01-01T23:59:59.000Z

126

Contact List, Human Resources  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Resources & Occupational Medicine Division Human Resources & Occupational Medicine Division Contact List Human Resources Guest, User, Visitor (GUV) Center Occupational Medicine Training and Qualifications Office Note: All listed phone extensions are in the format of (631) 344-xxxx. Human Resources Robert Lincoln, Chief Human Resources Officer x7435 rlincoln@bnl.gov Margaret Hughes x2108 hughes@bnl.gov Elizabeth Gilbert x2315 gilbert@bnl.gov Human Resources Generalists Christel Colon, HR Manager - BES, GARS & ELS x8469 ccolon@bnl.gov Joann Williams, HR Manager - Support Operations x8356 williamsj@bnl.gov Joanna Hall, HR Manager - Photon Sciences x4410 jhall@bnl.gov Donna Dowling, HR Manager - Nuclear & Particle Physics x2754 dowling@bnl.gov Terrence Buck x8715 tbuck@bnl.gov

127

Human Error Reduction  

Science Conference Proceedings (OSTI)

Reducing human error is recognized in the power-generation industry as a key factor in reducing safety-related events as well as improving asset availability. Achieving a sustainable culture change that leads to human error reduction in plant operations and maintenance remains a significant challenge to the industry. This report presents a behavior-based approach to human performance improvement and error reduction. The report explains fundamental elements of culture change and describes proven practices...

2010-12-23T23:59:59.000Z

128

Human and Gorilla Genes  

NLE Websites -- All DOE Office Websites (Extended Search)

Human and Gorilla Genes Name: Eileen B Status: NA Age: NA Location: NA Country: NA Date: NA Question: What are the differences between the genetic mechanisms which affect...

129

Human Reliability Program (HRP)  

Energy.gov (U.S. Department of Energy (DOE))

Office of SecurityHRP Training Certification- HTML- Flash10 CFR 712, Human Reliability ProgramHRP HandbookTools for Clinicians- Medication List- Medical Records Checklist

130

HQ - Human Resources Operations  

Energy.gov (U.S. Department of Energy (DOE))

HQs Human Recources Operations delivers services, including position management, recruitment, staffing and classification, and reduction in force at Headquarters.  Click the "Contacts" Link to find...

131

Human Radiation Experiments: Multimedia  

NLE Websites -- All DOE Office Websites (Extended Search)

the oral histories of researchers and others possessing firsthand knowledge of human radiation experimentation during World War II and the Cold War. Film Clips: Document...

132

Publications & Resources, Human Resources  

NLE Websites -- All DOE Office Websites (Extended Search)

or approved by Brookhaven National Laboratory or the Human Resources Division. Manuals Scientific Staff Manual Supervisors Personnel Manual SBMS Subject Areas Compensation...

133

HH Domain of Alzheimer’s Disease Ab Provides Structural Basis for Neuronal Binding in PC12 and Mouse Cortical/Hippocampal Neurons  

E-Print Network (OSTI)

A key question in understanding AD is whether extracellular Ab deposition of parenchymal amyloid plaques or intraneuronal Ab accumulation initiates the AD process. Amyloid precursor protein (APP) is endocytosed from the cell surface into endosomes where it is cleaved to produce soluble Ab which is then released into the brain interstitial fluid. Intraneuronal Ab accumulation is hypothesized to predominate from the neuronal uptake of this soluble extracellular Ab rather than from ER/Golgi processing of APP. We demonstrate that substitution of the two adjacent histidine residues of Ab40 results in a significant decrease in its binding with PC12 cells and mouse cortical/hippocampal neurons. These substitutions also result in a dramatic enhancement of both thioflavin-T positive fibril formation and binding to preformed Ab fibrils while maintaining its plaque-binding ability in AD transgenic mice. Hence, alteration of the histidine domain of Ab prevented neuronal binding and drove Ab to enhanced fibril formation and subsequent amyloid plaque deposition- a potential mechanism for removing toxic species of Ab. Substitution or even masking of these Ab histidine residues might provide a new therapeutic direction for minimizing neuronal uptake and subsequent neuronal degeneration and

Joseph F. Poduslo; Emily J. Gilles; Muthu Ramakrishnan; Kyle G. Howell; Thomas M. Wengenack; Geoffry L. Curran; Karunya K. K

2010-01-01T23:59:59.000Z

134

Aortoesophageal Fistula and Aortic Pseudoaneurysm Induced by Swallowed Fish Bone: A Report of Two Cases  

Science Conference Proceedings (OSTI)

Esophageal perforation caused by accidental swallowing of fish bones can lead to rare complications, such as aortoesophageal fistula accompanied by aortic pseudoaneurysm, which can be fatal if not properly handled. We report two rare cases of aortoesophageal fistula and aortic pseudoaneurysm caused by esophagus perforation after accidental swallow of fish bone; the patients also had purulent mediastinitis and esophagitis. The treatment of aortic pseudoaneurysm was successful in both cases, with one patient undergoing surgical resection and aortic neoplasty and the other patient undergoing endovascular stent graft placement. Long-term antibiotic treatment was administered to both patients after surgery. There were no postsurgical complications, and the patients recovered without incident.

Chen Aiping, E-mail: chenaiping-123@163.com; Yu Hong, E-mail: yuhongphd@163.com [Second Military Medical University, Department of Radiology, Changzheng Hospital (China); Li Huimin [Shanghai Jiaotong University School of Medicine, Department of Radiology, Xinhua Hospital (China); Xiao Xiangsheng, E-mail: cjr.xxsh@vip163.com; Liu Shiyuan [Second Military Medical University, Department of Radiology, Changzheng Hospital (China)

2011-02-15T23:59:59.000Z

135

Interacting with human physiology  

Science Conference Proceedings (OSTI)

We propose a novel system that incorporates physiological monitoring as part of the human-computer interface. The sensing element is a thermal camera that is employed as a computer peripheral. Through bioheat modeling of facial imagery almost the full ... Keywords: Blood flow, Breath rate, Cardiac pulse, Facial tracking, Human-computer interaction, Sleep apnea, Stress, Thermal imaging

I. Pavlidis; J. Dowdall; N. Sun; C. Puri; J. Fei; M. Garbey

2007-10-01T23:59:59.000Z

136

Humans and Gills  

NLE Websites -- All DOE Office Websites (Extended Search)

Humans and Gills Humans and Gills Name: Shelley Location: N/A Country: N/A Date: N/A Question: Is it true that some babies are born with some sort of gills? How and when do humans adapt from breathing inside to breathing outside of the womb? Replies: Whoa! You have received a great deal of false information. First, babies are not born with gills! Get that out of your thinking! Babies do not "breath" for oxygen in the womb. They do "practice breathing" using the amniotic fluid of the womb, but it is not doing them any good otherwise. All of the embryo and fetal needs are received through the placenta. The mother provides everything that is needed. As for the gills, there is a stage in the early human embryo development whereby humans do show gill slits, but not functional gills. Slits are not gills!! As a matter of fact, all vertebrates show these same gill slits.

137

Dynamic T{sub 2}-mapping during magnetic resonance guided high intensity focused ultrasound ablation of bone marrow  

Science Conference Proceedings (OSTI)

Focal bone tumor treatments include amputation, limb-sparing surgical excision with bone reconstruction, and high-dose external-beam radiation therapy. Magnetic resonance guided high intensity focused ultrasound (MR-HIFU) is an effective non-invasive thermotherapy for palliative management of bone metastases pain. MR thermometry (MRT) measures the proton resonance frequency shift (PRFS) of water molecules and produces accurate (<1 Degree-Sign C) and dynamic (<5s) thermal maps in soft tissues. PRFS-MRT is ineffective in fatty tissues such as yellow bone marrow and, since accurate temperature measurements are required in the bone to ensure adequate thermal dose, MR-HIFU is not indicated for primary bone tumor treatments. Magnetic relaxation times are sensitive to lipid temperature and we hypothesize that bone marrow temperature can be determined accurately by measuring changes in T{sub 2}, since T{sub 2} increases linearly in fat during heating. T{sub 2}-mapping using dual echo times during a dynamic turbo spin-echo pulse sequence enabled rapid measurement of T{sub 2}. Calibration of T{sub 2}-based thermal maps involved heating the marrow in a bovine femur and simultaneously measuring T{sub 2} and temperature with a thermocouple. A positive T{sub 2} temperature dependence in bone marrow of 20 ms/ Degree-Sign C was observed. Dynamic T{sub 2}-mapping should enable accurate temperature monitoring during MR-HIFU treatment of bone marrow and shows promise for improving the safety and reducing the invasiveness of pediatric bone tumor treatments.

Waspe, Adam C.; Looi, Thomas; Mougenot, Charles; Amaral, Joao; Temple, Michael; Sivaloganathan, Siv; Drake, James M. [Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, ON, M5G 1X8 (Canada); Philips Healthcare Canada, Markham, ON, L6C 2S3 (Canada); Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, ON, M5G 1X8 (Canada); Department of Applied Mathematics, University of Waterloo, Waterloo, ON, N2L 3G1 (Canada); Centre for Image Guided Innovation and Therapeutic Intervention, The Hospital for Sick Children, Toronto, ON, M5G 1X8 (Canada)

2012-11-28T23:59:59.000Z

138

Functional atrial natriuretic peptide receptor in human adrenal tumor  

SciTech Connect

The effects of synthetic human atrial natriuretic peptide (ANP) on the release of catecholamines, aldosterone, or cortisol were observed in human adrenal tumors obtained surgically from patients with pheochromocytoma, primary aldosteronism, or Cushing's syndrome, respectively. Each tumor tissue or adjacent normal cortical tissue was sectioned into slices, which were incubated in medium-199 in the presence or absence of adrenocorticotrophin (ACTH) and ANP. The amounts of epinephrine, norepinephrine, aldosterone, or cortisol released into the medium were measured. Existence of ANP receptors on the adrenal tissues was examined by binding assays, affinity labeling, and immunohistochemistry. Release of catecholamines from pheochromocytoma tissues was inhibited by ANP, and the presence of the ANP receptor on pheochromocytoma was further demonstrated by both binding assays and affinity labeling; Scatchard analysis revealed a single class of binding sites for ANP with a Kd of 1.0 nM and a Bmax of 0.4 pmol/mg of protein and the molecular size was estimated as 140 and a 70 kDa under nonreducing and reducing conditions, respectively. The presence of ANP receptors in pheochromocytoma was demonstrated by immunohistochemistry. ANP inhibited both basal and ACTH-stimulated aldosterone secretion in the slices of normal cortex, and localization of ANP receptors in zona glomerulosa cells was also demonstrated. However, ANP did not inhibit basal and ACTH-stimulated aldosterone and cortisol secretion in both tissue slices from aldosteronoma and Cushing's adenoma. Consistent with these observations, the absence of ANP receptors in adenoma tissues was determined by binding assays, affinity labeling, and immunohistochemistry.

Shionoiri, H.; Hirawa, N.; Takasaki, I.; Ishikawa, Y.; Oda, H.; Minamisawa, K.; Sugimoto, K.; Matsukawa, T.; Ueda, S.; Miyajima, E.

1989-01-01T23:59:59.000Z

139

Disposition Schedule: Human Radiation Experiments | Department...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Schedule: Human Radiation Experiments Disposition Schedule: Human Radiation Experiments This database contains information on records collections related to human radiation...

140

Refinement of the $n-\\alpha$ and $p-\\alpha$ fish-bone potential  

E-Print Network (OSTI)

The fishbone potential of composite particles simulates the Pauli effect by nonlocal terms. We determine the $n-\\alpha$ and $p-\\alpha$ fish-bone potential by simultaneously fitting to the experimental phase shifts. We found that with a double Gaussian parametrization of the local potential can describe the $n-\\alpha$ and $p-\\alpha$ phase shifts for all partial waves.

Smith, E; Papp, Z

2012-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Instrument for bone mineral measurement using a microprocessor as the control and arithmetic element  

SciTech Connect

A self-contained instrument for the determination of bone mineral content by photon absorptometry is described. A high-resolution detection system allows measurements to be made at up to 16 photon energies. Control and arithmetic functions are performed by a microprocessor. Analysis capability and limitations are discussed. (auth)

Alberi, J.L.; Hardy, W.H. II

1975-11-01T23:59:59.000Z

142

Effects of Vibrator Types and Their Placement on Bone?Conduction Threshold Measurements  

Science Conference Proceedings (OSTI)

Monaural bone?conduction threshold measurements in the quiet were obtained for 10 normally hearing young adults at both forehead and mastoid positions using two hearing?aid?type vibrators of different manufacture. Physical calibration data for the vibrators were obtained by other laboratories

Peter B. Weston; Roy W. Gengel; Ira J. Hirsh

1966-01-01T23:59:59.000Z

143

Ocean Health and Human Health  

E-Print Network (OSTI)

et al. 2002. Indicators of ocean health and human health:Nature 423:280–283. Oceans and Human Health Act. 2003. S.Editorial Guest Editorial Ocean Health and Human Health

2004-01-01T23:59:59.000Z

144

ALSNews Vol. 311  

NLE Websites -- All DOE Office Websites (Extended Search)

1 Print 1 Print Irradiation Effects on Human Cortical Bone Fracture Behavior The role irradiation plays in high-exposure bone fracturing experiments, and how it affects the properties of bone tissue, are not fully understood. To better predict fracturing in bone, researchers must understand the role of sustained irradiation damage at different size scales within bone. Using synchrotron radiation microtomography at ALS Beamline 8.3.2, researchers investigated changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that this can lead to drastic losses in strength, ductility, and toughness. Read more... Contact: Robert O. Ritchie Investigating Extreme Ultraviolet Lithography Mask Defects Printing computer chips using extreme ultraviolet (EUV) lithography will enable the production of smaller, faster, and cheaper semiconductors. EUV lithography relies on specialized, curved-mirror lenses to print patterns with high resolution. One special flat mirror called a mask is particularly sensitive to even the smallest imperfections. To better detect and characterize mask defects, Berkeley Lab scientists worked with an international semiconductor industry consortium to create a unique Fresnel zoneplate microscope on ALS Beamline 11.3.2: The SEMATECH Berkeley Actinic Inspection Tool (AIT). Read more...

145

ALSNews Vol. 311  

NLE Websites -- All DOE Office Websites (Extended Search)

1 Print 1 Print Irradiation Effects on Human Cortical Bone Fracture Behavior The role irradiation plays in high-exposure bone fracturing experiments, and how it affects the properties of bone tissue, are not fully understood. To better predict fracturing in bone, researchers must understand the role of sustained irradiation damage at different size scales within bone. Using synchrotron radiation microtomography at ALS Beamline 8.3.2, researchers investigated changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that this can lead to drastic losses in strength, ductility, and toughness. Read more... Contact: Robert O. Ritchie Investigating Extreme Ultraviolet Lithography Mask Defects Printing computer chips using extreme ultraviolet (EUV) lithography will enable the production of smaller, faster, and cheaper semiconductors. EUV lithography relies on specialized, curved-mirror lenses to print patterns with high resolution. One special flat mirror called a mask is particularly sensitive to even the smallest imperfections. To better detect and characterize mask defects, Berkeley Lab scientists worked with an international semiconductor industry consortium to create a unique Fresnel zoneplate microscope on ALS Beamline 11.3.2: The SEMATECH Berkeley Actinic Inspection Tool (AIT). Read more...

146

Global Environmental Change and Human Security  

E-Print Network (OSTI)

with human rights, human security or environmental change ifEnvironmental Change and Human Security By Matthew, RichardChange and Human Security. Cambridge, Massachusetts &

Kunnas, Jan

2011-01-01T23:59:59.000Z

147

Effectiveness of Reirradiation for Painful Bone Metastases: A Systematic Review and Meta-Analysis  

Science Conference Proceedings (OSTI)

Purpose: Reirradiation of painful bone metastases in nonresponders or patients with recurrent pain after initial response is performed in up to 42% of patients initially treated with radiotherapy. Literature on the effect of reirradiation for pain control in those patients is scarce. In this systematic review and meta-analysis, we quantify the effectiveness of reirradiation for achieving pain control in patients with painful bone metastases. Methods and Materials: A free text search was performed to identify eligible studies using the MEDLINE, EMBASE, and the Cochrane Collaboration library electronic databases. After study selection and quality assessment, a pooled estimate was calculated for overall pain response for reirradiation of metastatic bone pain. Results: Our literature search identified 707 titles, of which 10 articles were selected for systematic review and seven entered the meta-analysis. Overall study quality was mediocre. Of the 2,694 patients initially treated for metastatic bone pain, 527 (20%) patients underwent reirradiation. Overall, a pain response after reirradiation was achieved in 58% of patients (pooled overall response rate 0.58, 95% confidence interval = 0.49-0.67). There was a substantial between-study heterogeneity (I{sup 2} = 63.3%, p = 0.01) because of clinical and methodological differences between studies. Conclusions: Reirradiation of painful bone metastases is effective in terms of pain relief for a small majority of patients; approximately 40% of patients do not benefit from reirradiation. Although the validity of results is limited, this meta-analysis provides a comprehensive overview and the most quantitative estimate of reirradiation effectiveness to date.

Huisman, Merel, E-mail: m.huisman-7@umcutrecht.nl [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands)] [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands); Bosch, Maurice A.A.J. van den; Wijlemans, Joost W. [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands)] [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands); Vulpen, Marco van [Department of Radiotherapy, University Medical Center Utrecht, Utrecht (Netherlands)] [Department of Radiotherapy, University Medical Center Utrecht, Utrecht (Netherlands); Linden, Yvette M. van der [Department of Clinical Oncology, Leiden University Medical Center, Leiden (Netherlands)] [Department of Clinical Oncology, Leiden University Medical Center, Leiden (Netherlands); Verkooijen, Helena M. [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands)] [Department of Radiology, University Medical Center Utrecht, Utrecht (Netherlands)

2012-09-01T23:59:59.000Z

148

Butyl benzyl phthalate suppresses the ATP-induced cell proliferation in human osteosarcoma HOS cells  

Science Conference Proceedings (OSTI)

Butyl benzyl phthalate (BBP), an endocrine disruptor present in the environment, exerts its genomic effects via intracellular steroid receptors and elicits non-genomic effects by interfering with membrane ion-channel receptors. We previously found that BBP blocks the calcium signaling coupled with P2X receptors in PC12 cells (Liu and Chen, 2006). Osteoblast P2X receptors were recently reported to play a role in cell proliferation and bone remodeling. In this present study, the effects of BBP on ATP-induced responses were investigated in human osteosarcoma HOS cells. These receptors mRNA had been detected, named P2X4, P2X7, P2Y2, P2Y4, P2Y5, P2Y9, and P2Y11, in human osteosarcoma HOS cells by RT-PCR. The enhancement of cell proliferation and the decrease of cytoviability had both been shown to be coupled to stimulation via different concentrations of ATP. BBP suppressed the ATP-induced calcium influx (mainly coupled with P2X) and cell proliferation but not the ATP-induced intracellular calcium release (mainly coupled with P2Y) and cytotoxicity in human osteosarcoma HOS cells. Suramin, a common P2 receptor's antagonist, blocked the ATP-induced calcium signaling, cell proliferation, and cytotoxicity. We suggest that P2X is mainly responsible for cell proliferation, and P2Y might be partially responsible for the observed cytotoxicity. BBP suppressed the calcium signaling coupled with P2X, suppressing cell proliferation. Since the importance of P2X receptors during bone metastasis has recently become apparent, the possible toxic risk of environmental BBP during bone remodeling is a public problem of concern.

Liu, P.-S., E-mail: pslediting@mail.scu.edu.t [Department of Microbiology, Soochow University, Shihlin, Taipei, Taiwan (China); Chen, C.-Y. [Department of Microbiology, Soochow University, Shihlin, Taipei, Taiwan (China)

2010-05-01T23:59:59.000Z

149

Human Radiation Experiments: What's New  

NLE Websites -- All DOE Office Websites (Extended Search)

of Defense Report Finding Aids Department of Defense Report on Search for Human Radiation Experiments Records 1944-1994 Exit Human Radiation Experiments Site This...

150

Spontaneous Human Combustion  

NLE Websites -- All DOE Office Websites (Extended Search)

Spontaneous Human Combustion Spontaneous Human Combustion Name: S. Phillips. Age: N/A Location: N/A Country: N/A Date: N/A Question: One of our 8th grade students has tried to find information in our library about spontaneous human combustion, but to no avail. Could you tell us where we might locate a simple reference, or provide some in information about this subject for him. Replies: Sorry, but this is definitely "fringe science"...try asking in bookstores. I seem to recall one of those "believe it or not" type of TV shows did an episode on spontaneous human combustion a few years ago in which they reported on some British scientists who investigated this purported phenomenon. Remember that people (back in the Dark Ages, and before) used to believe in "spontaneous generation" of certain plants and animals because they were not aware of the reproduction methods used by those plants and animals.

151

Macintosh human interface guidelines  

Science Conference Proceedings (OSTI)

Macintosh Human Interface Guidelines describes the way to create products that optimize the interaction between people and Macintosh computers. It explains the whys and hows of the Macintosh interface in general terms and specific details. Macintosh ...

Apple Computer, Inc.

1992-01-01T23:59:59.000Z

152

KRFTWRK – Global Human Electricity  

E-Print Network (OSTI)

Power Network 2.1.1 Virtual Power Plants The Global Powernetwork, based on "Virtual Power Plants", called "VPP". A "participant runs a virtual human power plant. Per every "

Prohaska, Rainer

2009-01-01T23:59:59.000Z

153

Medical Humanities Introduction  

E-Print Network (OSTI)

in the making: Memoirs and medical education. Iowa City, IA:shoes: empathy and othering in medical students' education.through the thread of medical humanities 1 . The essay by

Shapiro, Johanna

2009-01-01T23:59:59.000Z

154

Dogs and Human Diseases  

NLE Websites -- All DOE Office Websites (Extended Search)

Diseases Name: Doris Status: Other Grade: 9-12 Location: OK Date: NA Question: Can a dog contact the shingles or chicken pox virus from a human? Replies: Hi Doris, Great...

155

Human Factors Review Plan  

SciTech Connect

''Human Factors'' is concerned with the incorporation of human user considerations into a system in order to maximize human reliability and reduce errors. This Review Plan is intended to assist in the assessment of human factors conditions in existing DOE facilities. In addition to specifying assessment methodologies, the plan describes techniques for improving conditions which are found to not adequately support reliable human performance. The following topics are addressed: (1) selection of areas for review describes techniques for needs assessment to assist in selecting and prioritizing areas for review; (2) human factors engineering review is concerned with optimizing the interfaces between people and equipment and people and their work environment; (3) procedures review evaluates completeness and accuracy of procedures, as well as their usability and management; (4) organizational interface review is concerned with communication and coordination between all levels of an organization; and (5) training review evaluates training program criteria such as those involving: trainee selection, qualification of training staff, content and conduct of training, requalification training, and program management.

Paramore, B.; Peterson, L.R. (eds.)

1985-12-01T23:59:59.000Z

156

Developing Human Performance Measures  

Science Conference Proceedings (OSTI)

Through the reactor oversight process (ROP), the U.S. Nuclear Regulatory Commission (NRC) monitors the performance of utilities licensed to operate nuclear power plants. The process is designed to assure public health and safety by providing reasonable assurance that licensees are meeting the cornerstones of safety and designated crosscutting elements. The reactor inspection program, together with performance indicators (PIs), and enforcement activities form the basis for the NRC’s risk-informed, performance based regulatory framework. While human performance is a key component in the safe operation of nuclear power plants and is a designated cross-cutting element of the ROP, there is currently no direct inspection or performance indicator for assessing human performance. Rather, when human performance is identified as a substantive cross cutting element in any 1 of 3 categories (resources, organizational or personnel), it is then evaluated for common themes to determine if follow-up actions are warranted. However, variability in human performance occurs from day to day, across activities that vary in complexity, and workgroups, contributing to the uncertainty in the outcomes of performance. While some variability in human performance may be random, much of the variability may be attributed to factors that are not currently assessed. There is a need to identify and assess aspects of human performance that relate to plant safety and to develop measures that can be used to successfully assure licensee performance and indicate when additional investigation may be required. This paper presents research that establishes a technical basis for developing human performance measures. In particular, we discuss: 1) how historical data already gives some indication of connection between human performance and overall plant performance, 2) how industry led efforts to measure and model human performance and organizational factors could serve as a data source and basis for a framework, 3) how our use of modeling and simulation techniques could be used to develop and validate measures of human performance, and 4) what the possible outcomes are from this research as the modeling and simulation efforts generate results.

Jeffrey Joe; Bruce Hallbert; Larry Blackwood; Donald Dudehoeffer; Kent Hansen

2006-05-01T23:59:59.000Z

157

A Primer to Human Threading  

Science Conference Proceedings (OSTI)

Human Threading(TM) is new approach in developing innovative computing technologies. It uses novel physiologic combinations to measure the human brain and body in an effort to create greater efficiency among human and machine. A divergent group of measurement ... Keywords: BCI, EEG, HCI, Human ThreadingTM, Information systems

Christopher Liapis

2011-01-01T23:59:59.000Z

158

Human radiation studies: Remembering the early years. Oral history of hematologist Karl F. Hubner, M.D., December 30, 1994  

SciTech Connect

This report is a transcript of an interview of Dr. Karl F. Hubner by representatives of the US DOE Human Radiation Experiments. Dr. Hubner was selected for this interview because of his participation in the Oak Ridge Institute of Nuclear Studies(ORINS)/Oak Ridge Associated Universities(ORAU) Medical Division cancer therapy research program involving total body irradiation. After a short biographical sketch Dr. Hubner discusses his research in Bone Marrow Transplants, his participation in the development of Nuclear Medicine in Oak Ridge, use of the total body irradiation machine at the University of Tennessee School of Agriculture Animal Research Laboratory (later the Comparative Animal Research Laboratory or CARL) to deliver a high enough dose rate to destroy a patients immune system, the operation of a sterile environment for recovery of patients following bone- marrow transplantation, and the closing of the ORAU Medical Division`s Clinical Program following a negative review. Finally, Dr. Hubner describes his later research using PET.

1995-09-01T23:59:59.000Z

159

Turkey vs. human digestion  

NLE Websites -- All DOE Office Websites (Extended Search)

Turkey vs. human digestion Turkey vs. human digestion Name: wallyb Location: N/A Country: N/A Date: N/A Question: How is the digestive system of turkeys different from that of humans? Replies: Hmmm.. been a while since I had sophomore biology, so I can't completely answer this one, but I can say a few things. One, since turkeys are birds, and birds as a general rule have not had teeth for several million years at least, the turkey needs a way to mash up its food -- thus, the crop, which is essentially like another stomach: the turkey (and many other birds, for that matter) swallows small stones which serve in lieu of teeth, mashing up food via muscular action in the crop, from whence the "chewed" food moves on into the rest of the digestive tract. As for any other differences, I'll have to leave that to someone else with more ornithological experience...

160

Relocation Guide, Human Resources  

NLE Websites -- All DOE Office Websites (Extended Search)

Relocation Information Guide Relocation Information Guide The Human Resources Division is providing this Information Guide to you to help ease the transition of relocating to Long Island. Relocating to a new place can be an exciting as well as stressful time. We have compiled information that can be very helpful with the many issues you may face. You may also seek assistance from the recruiter you work with in Human Resources. Service Disclaimer - This web page contains links to other Internet sites. These links are not endorsements of any products or services and no information in such site has been endorsed or approved by Brookhaven National Laboratory or the Human Resources Division. Here are some of the issues: Cost of living Buying or renting a home Schools in the area

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

THE HUMAN FACTOR* By  

E-Print Network (OSTI)

*I gratefully acknowledge the advice, encouragement, and inspiration of Nuria Chinchilla from IESE who encouraged me to think about the issue of human sustainability in both societies and companies. The helpful comments of the editor and the reviewers substantially clarified the arguments. ACADEMY OF MANAGEMENT PERSPECTIVES, (in press) Although most of the research and public pressure concerning sustainability has been focused on the effects of business and organizational activity on the physical environment, companies and their management practices profoundly affect the human and social environment as well. This article briefly reviews the literature on the direct and indirect effects of organizations and their decisions about people on human health and mortality. It then considers some possible explanations for why social sustainability has received relatively short shrift in management writing, and outlines a research agenda for investigating the links between social sustainability and organizational effectiveness as well as the role

Jeffrey Pfeffer; R Esearch; P Aper; S Eries; Building Sustainable Organizations; Jeffrey Pfeffer

2010-01-01T23:59:59.000Z

162

Aluminum silicate nanotube coating of siloxane-poly(lactic acid)-vaterite composite fibermats for bone regeneration  

Science Conference Proceedings (OSTI)

In our earlier work, a flexible fibermat consisting of a biodegradable composite with soluble silicate species, which has been reported to enhance bone formation, was prepared successfully using poly(L-lactic acid) and siloxane-containing calcium carbonate ...

Shuji Yamazaki, Hirotaka Maeda, Akiko Obata, Keiichi Inukai, Katsuya Kato, Toshihiro Kasuga

2012-01-01T23:59:59.000Z

163

Potential commercial application of a bi-layer bone-ligament regeneration scaffold to anterior cruciate ligament replacement  

E-Print Network (OSTI)

A business model was created in order to explore the commercial application of a bi-layer bone-ligament scaffold to the treatment of torn anterior cruciate ligaments (ACL) requiring replacement. The two main keys in producing ...

Li, Jessica C. (Jessica Ching-Yi)

2006-01-01T23:59:59.000Z

164

Three dimensional modeling and analysis of Haversian systems in compact bone tissue  

E-Print Network (OSTI)

This study provides a qualitative as well as quantitative characterization of the geometry and architecture of the Haversian systems at a microscopic level. A procedure was developed and employed to generate a three dimensional computer model from serial sections of equine bone. From the reconstruction, quantitative calculations were made. including porosity. surface areas. cross sectional areas, anci cross sectional shapes. Also the porosity due to Volkmann canals was estimated. Other more qualitative calculations included the nature of branching. termination. taper'n-and-general osteon movement. Any chance in the specimen size or shape during, the entire processing-was carefully documented and corrected for where possible. One of the goals of the research was to assess and evaluate the procedures developed and identify ways to further improve accuracy. With a computerized three dimensional imag-e of the bone microstructure. detailed calculations can be made and insig-ht cained more accurately than with two dimensional models or past three dimensional models.

Deisseroth, Kate

1995-01-01T23:59:59.000Z

165

Cortical Control of Affective Networks  

E-Print Network (OSTI)

Transcranial magnetic stimulation and deep brain stimulation have emerged as therapeutic modalities for treatment refractory depression; however, little remains known regarding the circuitry that mediates the therapeutic ...

Kumar, S.

166

Human MSH2 protein  

DOE Patents (OSTI)

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.

Chapelle, A. de la; Vogelstein, B.; Kinzler, K.W.

1997-01-07T23:59:59.000Z

167

Human MSH2 protein  

DOE Patents (OSTI)

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

de la Chapelle, Albert (Helsingfors, FI); Vogelstein, Bert (Baltimore, MD); Kinzler, Kenneth W. (Baltimore, MD)

1997-01-01T23:59:59.000Z

168

Imaging the Material Properties of Bone Specimens Using Reflection-Based Infrared Microspectroscopy  

Science Conference Proceedings (OSTI)

Fourier transform infrared microspectroscopy (FTIRM) is a widely used method for mapping the material properties of bone and other mineralized tissues, including mineralization, crystallinity, carbonate substitution, and collagen cross-linking. This technique is traditionally performed in a transmission-based geometry, which requires the preparation of plastic-embedded thin sections, limiting its functionality. Here, we theoretically and empirically demonstrate the development of reflection-based FTIRM as an alternative to the widely adopted transmission-based FTIRM, which reduces specimen preparation time and broadens the range of specimens that can be imaged. In this study, mature mouse femurs were plastic-embedded and longitudinal sections were cut at a thickness of 4 {micro}m for transmission-based FTIRM measurements. The remaining bone blocks were polished for specular reflectance-based FTIRM measurements on regions immediately adjacent to the transmission sections. Kramers-Kronig analysis of the reflectance data yielded the dielectric response from which the absorption coefficients were directly determined. The reflectance-derived absorbance was validated empirically using the transmission spectra from the thin sections. The spectral assignments for mineralization, carbonate substitution, and collagen cross-linking were indistinguishable in transmission and reflection geometries, while the stoichiometric/nonstoichiometric apatite crystallinity parameter shifted from 1032/1021 cm{sup -1} in transmission-based to 1035/1025 cm{sup -1} in reflection-based data. This theoretical demonstration and empirical validation of reflection-based FTIRM eliminates the need for thin sections of bone and more readily facilitates direct correlations with other methods such as nanoindentation and quantitative backscatter electron imaging (qBSE) from the same specimen. It provides a unique framework for correlating bone's material and mechanical properties.

Acerbo A. S.; Carr, G.L.; Judex, S.; Miller, L.M.

2012-03-13T23:59:59.000Z

169

Unconventional human computer interfaces  

Science Conference Proceedings (OSTI)

This course focuses on how we can use the potential of the human body in experimental or unconventional interface techniques. It explores the biological or physiological characteristics of the separate parts of the body, from head to toe, and from skin ...

Steffi Beckhaus; Ernst Kruijff

2004-08-01T23:59:59.000Z

170

Human computing and machine understanding of human behavior: a survey  

Science Conference Proceedings (OSTI)

A widely accepted prediction is that computing will move to the background, weaving itself into the fabric of our everyday living spaces and projecting the human user into the foreground. If this prediction is to come true, then next generation computing ... Keywords: affective computing, analysis, human behavior understanding, human sensing, multimodal data, socially-aware computing

Maja Pantic; Alex Pentland; Anton Nijholt; Thomas S. Huang

2007-01-01T23:59:59.000Z

171

Human Capital Plan | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Plan Human Capital Plan More Documents & Publications Strategic Use of Human Capital DOE Strategic Human Capital Plan (FY 2011 - 2015) Energy.gov Careers & Internships For Staff &...

172

Modelling postures of human movements  

Science Conference Proceedings (OSTI)

The goal of this paper is to present a novel modelling of postures of human activities such us walk, run... Effectively, human action is, in general, characterized by a sequence of specific body postures. So, from an incoming sequence video, we determine ... Keywords: human activities, modelling, shape matching, skeleton, thinning

Djamila Medjahed Gamaz; Houssem Eddine Gueziri; Nazim Haouchine

2010-11-01T23:59:59.000Z

173

Radiation effects on humans  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation effects on humans Radiation effects on humans Name: Joe Kemna Location: N/A Country: N/A Date: N/A Question: I am trying to find information on radiation. I need the effects on humans, the damage it causes to the environment, and any extra information you might have on the subject. Thank you for your time. Replies: Your library should be a good place to start, but first you need to narrow your question a bit. "Radiation" means radio waves, heat, light (including the ultraviolet light that causes suntan and sunburn), and what's called "ionizing radiation." By far the major source of the first three is the Sun, while the last I believe comes principally from cosmic rays and various naturally radioactive elements like uranium and radon. The most significant manmade sources of exposure would --- I think --- be household wiring and appliances (radio), engines and heating devices (heat), lamps (light), and X-ray machines, flying at high altitude in airplanes, and living in well-insulated homes built over radon sources (ionizing radiation). Heat, light and ionizing radiation play vital roles in the ecology of the Earth. Radio, light (in particular "tanning" ultraviolet), and ionizing radiation have all been widely assumed at different times to be particularly good or particularly bad for human health. Some recent issues of public concern have been the effect of radio waves from electric transmission lines, the effect on skin cancer incidence from tanning and sunburns, the depletion of the ultraviolet-light-produced ozone in the upper atmosphere by chlorofluorocarbons (CFCs), "global warming" from the increased absorption of heat radiation from the surface by atmospheric carbon dioxide and methane, and the effect of a long exposure to low levels of ionizing radiation as for example the people of Eastern Europe are experiencing from the Chernobyl nuclear power plant accident.

174

Poster Session - Programmaster.org  

Science Conference Proceedings (OSTI)

The metal ion-reducing bacterium, Shewanella algae, was able to reduced metal ... Developed here is a micro-scale-based flow stress model of cortical bone.

175

Applications of Polymer Nanofibers in Bio-materials, Biotechnology ...  

Science Conference Proceedings (OSTI)

An Alternate Approach for Characterizing the Fracture Resistance of Cycloid Fish Scales · An Experimentally-based Flow Stress Model for Cortical Bone.

176

Eye Color in Humans  

NLE Websites -- All DOE Office Websites (Extended Search)

Eye Color in Humans Eye Color in Humans Name: Kristi Location: N/A Country: N/A Date: N/A Question: The dominant characteristic is the one most likely to appear in the offspring. In human beings, brown is the dominant color for eyes. The children who inherit at least on dominant gene will have either brown, green, or hazel eyes. Only childten who inherit two recessive genes will have pure blue eyes. If there are eight children in the family, what color eyes will most of them have? Replies: http://www.newton.dep.anl.gov/archive.htm Search under eye color Steve Sample You answer is of course dependent on the genes of the parents. If both parents do not have the recessive gene, then no children will have light colored eyes. If one has a recessive gene and the other not, then still no children will have light color eyes and on the average 25% of the eight children could have the recessive gene. If both parents have the recessive gene, then 25% of the eight children could have light color eyes.

177

Dog vs. human language  

NLE Websites -- All DOE Office Websites (Extended Search)

Dog vs. human language Dog vs. human language Name: Michelle Conte Location: N/A Country: N/A Date: N/A Question: Why can't dogs talk like humans? Replies: In very simple terms, they aren't made for it. In order to produce any kind of vocal sound, we not only need a set of vocal chords (or vibratory organs of some sort), we also need an air pipe and cranium shaped to deliver the vibrations in the right way -- you actually use your own head as a sort of sounding plate for several primary sounds (non-percussive) Dogs don't have the right shaped heads for the job, as well as the inability to vocalize many of the percussive sounds which make up a good percentage of our languages due to a differently shaped mouth. However, all things considered, we'd be ill-equipped to call meetings over long distances by simply howling, like dogs and their kin are wont to do in the wild.

178

Human factoring administrative procedures  

Science Conference Proceedings (OSTI)

In nonnuclear business, administrative procedures bring to mind such mundane topics as filing correspondence and scheduling vacation time. In the nuclear industry, on the other hand, administrative procedures play a vital role in assuring the safe operation of a facility. For some time now, industry focus has been on improving technical procedures. Significant efforts are under way to produce technical procedure requires that a validated technical, regulatory, and administrative basis be developed and that the technical process be established for each procedure. Producing usable technical procedures requires that procedure presentation be engineered to the same human factors principles used in control room design. The vital safety role of administrative procedures requires that they be just as sound, just a rigorously formulated, and documented as technical procedures. Procedure programs at the Tennessee Valley Authority and at Boston Edison's Pilgrim Station demonstrate that human factors engineering techniques can be applied effectively to technical procedures. With a few modifications, those same techniques can be used to produce more effective administrative procedures. Efforts are under way at the US Department of Energy Nuclear Weapons Complex and at some utilities (Boston Edison, for instance) to apply human factors engineering to administrative procedures: The techniques being adapted include the following.

Grider, D.A.; Sturdivant, M.H.

1991-11-01T23:59:59.000Z

179

Virtual Human Problem Solving Environments  

SciTech Connect

Abstract. Interest in complex integrated digital or virtual human modeling has seen a significant increase over the last decade. Coincident with that increased interest, Oak Ridge National Laboratory (ORNL) initiated the development of a human simulation tool, the Virtual Human. The Virtual Human includes a problem-solving environment (PSE) for implementing the integration of physiological models in different programming languages and connecting physiological function to anatomy. The Virtual Human PSE (VHPSE) provides the computational framework with which to develop the concept of a "Virtual Human." Supporting the framework is a data definition for modeling parameters, PhysioML, a Virtual Human Database (VHDB), and a Web-based graphical user interface (GUI) developed using Java. Following description of the VHPSE, we discuss four example implementations of models within the framework. Further expansion of a human modeling environment was carried out in the Defense Advanced Research Projects Agency Virtual Soldier Project. SCIRun served as the Virtual Soldier problem solving environment (VSPSE). We review and compare specific developments in these projects that have significant potential for the future of Virtual Human modeling and simulation. We conclude with an evaluation of areas of future work that will provide important extensions to the VHPSE and VSPSE and make possible a fully-integrated environment for human anatomical and physiological modeling: the Virtual Human.

Ward, Richard C [ORNL; Pouchard, Line Catherine [ORNL; Munro, Nancy B [ORNL; Fischer, Sarah Kathleen [ORNL

2008-01-01T23:59:59.000Z

180

Ethos and answerability in the novelized epic: passional readings of Elizabeth Barrett Browning's Aurora Leigh, David Jones's In Parenthesis, and Chenjerai Hove's Bones  

E-Print Network (OSTI)

This study proposes an approach to a solution for the problem of the perceived ‚separatedness? of language from reality which employs the rhetorical concept of ethos, the doctrinal concept of the Chalcedonian definition of the nature of the incarnated Christ, and Mikhail Bakhtin’s notion of ‚answerability.? As an alternative to theories of reading and interpretation based on the arbitrariness of linguistic meaning, radical skepticism, and the death of the author, the approach defined in this study emphasizes affirmation of the centrality of the human person and the necessity of close, loving attention as the grounds of both aesthetic vision and ethical action. Developing three exemplary readings of novelized epics including Elizabeth Barrett Browning’s Aurora Leigh, David Jones’s In Parenthesis, and Chenjerai Hove’s Bones, the study demonstrates how loving, careful attention to ethos—the definition of which is expanded to include relationships between language and character in literary works, genres, characters, authors, and teachers—is the prerequisite for answerability in literary relationships. Whether one is primarily interested in authors, characters, genres, canon, readers, or critical reception, attention to ethos illuminates the ways in which responses to literary works are conditioned by and analogous to responses to persons. The complex and irreducible relationships between the ‚word? and the ‚person? require an individual answerability for which there is no alibi. Ultimately, the ‚word? and the ‚world? are united in the answerable person, whether that person is an author, a character, a reader, a critic or a teacher.

Sibley, Pamela Jean

2008-12-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Human activity recognition based on surrounding things  

Science Conference Proceedings (OSTI)

This paper proposes human activity recognition based on the actual semantics of the human’s current location. Since predefining the semantics of location is inadequate to identify human activities, we process information about things to automatically ...

Naoharu Yamada; Kenji Sakamoto; Goro Kunito; Kenichi Yamazaki; Satoshi Tanaka

2005-12-01T23:59:59.000Z

182

Lead effects on development and function of bone marrow-derived dendritic cells promote Th2 immune responses  

SciTech Connect

Although lead (Pb) has significant effects on the development and function of macrophages, B cells, and T cells and has been suggested to promote allergic asthma in mice and humans, Pb modulation of bone marrow (BM)-derived dendritic cells (DCs) and the resultant DC effects on Th1 and Th2 development have not been examined. Accordingly, we cultured BM cells with murine granulocyte macrophage-colony stimulating factor (mGM-CSF) {+-} PbCl{sub 2}. At day 10, culture supernatant (SN) and non-adherent cells were harvested for analysis. Additionally, day 10 non-adherent BM-DCs were harvested and recultured with mGM-CSF + LPS {+-} Pb for 2 days. The day 10 Pb exposure significantly inhibited BM-DC generation, based on CD11c expression. Although fewer DCs were generated with Pb, the existing Pb-exposed DCs had significantly greater MHC-II expression than did the non-Pb-exposed DCs. However, these differences diminished upon LPS stimulation. After LPS stimulation, CD80, CD86, CD40, CD54, and MHC-II were all up-regulated on both Pb-DCs and DCs, but Pb-DCs expressed significantly less CD80 than did DCs. The CD86:CD80 ratio suggests a Pb-DC potential for Th2 cell development. After LPS stimulation, IL-6, IL-10, IL-12 (p70), and TNF-{alpha} levels significantly increased with both Pb-DCs and DCs, but Pb-DCs produced significantly less cytokines than did DCs, except for IL-10, which further supports Pb-DC preferential skewing toward type-2 immunity. In vitro studies confirm that Pb-DCs have the ability to polarize antigen-specific T cells to Th2 cells. Pb-DCs also enhanced allogeneic and autologous T cell proliferation in vitro, and in vivo studies suggested that Pb-DCs inhibited Th1 effects on humoral and cell-mediated immunity. The Pb effect was mainly on DCs, rather than on T cells, and Pb's modification of DC function appears to be the main cause of Pb's promotion of type-2-related immunity, which may relate to Pb's enhanced activation of the Erk/MAP kinase pathway.

Gao Donghong [Biggs Laboratory, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201-0509 (United States); Mondal, Tapan K. [Biggs Laboratory, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201-0509 (United States); Lawrence, David A. [Biggs Laboratory, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201-0509 (United States)]. E-mail: lawrencd@wadsworth.org

2007-07-01T23:59:59.000Z

183

Biomaterials 24 (2003) 12131221 Extracellular matrix production by human osteoblasts cultured on  

E-Print Network (OSTI)

] Duneas N, Crooks J, Ripamount U. Transforming growth factor- b1: induction of bone morphogenetic protein

Lu, Helen H.

184

PIA - Human Resources - Personal Information Change Request ...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Laboratory PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory More Documents & Publications PIA - Human Resources Information...

185

Human portable preconcentrator system  

DOE Patents (OSTI)

A preconcentrator system and apparatus suited to human portable use wherein sample potentially containing a target chemical substance is drawn into a chamber and through a pervious screen. The screen is adapted to capture target chemicals and then, upon heating, to release those chemicals into the chamber. Chemicals captured and then released in this fashion are then carried to a portable chemical detection device such as a portable ion mobility spectrometer. In the preferred embodiment, the means for drawing sample into the chamber comprises a reversible fan which, when operated in reverse direction, creates a backpressure that facilitates evolution of captured target chemicals into the chamber when the screen is heated.

Linker, Kevin L. (Albuquerque, NM); Bouchier, Francis A. (Albuquerque, NM); Hannum, David W. (Albuquerque, NM); Rhykerd, Jr., Charles L. (Albuquerque, NM)

2003-01-01T23:59:59.000Z

186

Human subjects research handbook: Protecting human research subjects. Second edition  

SciTech Connect

This handbook serves as a guide to understanding and implementing the Federal regulations and US DOE Orders established to protect human research subjects. Material in this handbook is directed towards new and continuing institutional review board (IRB) members, researchers, institutional administrators, DOE officials, and others who may be involved or interested in human subjects research. It offers comprehensive overview of the various requirements, procedures, and issues relating to human subject research today.

NONE

1996-01-30T23:59:59.000Z

187

Regional geologic characterization of the Second Bone Spring Sandstone, Delaware basin, Lea and Eddy Counties, New Mexico  

E-Print Network (OSTI)

The Bone Spring Formation is a series of interbedded siliciclastics and carbonates that were deposited in the Delaware basin during the Leonardian (Early Permian). It consists of the First, Second and Third Carbonate and the First, Second and Third Sandstone, as well as the informally named Avalon Sandstone. The Second Bone Spring Sandstone, the focus of the study, can be subdivided into 4 distinct sand bodies separated by pelagic zones. These sands are designated the A-D Sands. The depositional patterns of the Bone Spring Formation are reflective of the underlying structure that resulted from compression during the Mississippian and Pennsylvanian. The Second Bone Spring Sandstone (specifically the C Sand) is essentially a dolomitic, coarse siltstone that is composed of facies reflective of deposition by turbidity currents in a slope fan environment. The midfan, levee/overbank and hemipelagic environments of deposition identified in the Second Bone Spring Sandstone are consistent with those of the typical slope fan of Walker (1978). The slope fans of the C Sand were confined by north-to-south trending reverse faults, which inhibited lateral migration of both the fans and the channels within them. The A-D Sands are correlatable throughout the study area but thicken in the underlying structural lows. These thicker sands are lobate in plan view and are located adjacent to, rather than directly on top of, underlying thick sands. This is likely a result of differential compaction of underlying sediment which served to further confine the fans. The sediment comprising the Second Bone Spring Sandstone was likely transported through basinward migration of sand dunes in an arid environment during relative sea level lowstands. Periodically, brief rises in sea level choked off sediment supply allowing hemipelagic material to be draped over underlying sands. With sea level fall, sands were again deposited in the tectonic sub-basins.

Downing, Amanda Beth

2001-01-01T23:59:59.000Z

188

Report: EM Human Capital Initiatives  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

HUMAN CAPITAL HUMAN CAPITAL September 25, 2008 Submitted by the EMAB Human Capital Subcommittee Background: The enhancement of the Office of Environmental Management's (EM) human capital has been a central tenet of the Assistant Secretary's tenure, reflecting the critical nature of this resource to the achievement of EM's mission. Beginning in Fiscal Year (FY) 2006, the Environmental Management Advisory Board (EMAB or Board) has reviewed the program's human capital issues and the plans EM has developed to address them. This review produced a number of recommendations that were presented in the Board's FY 2006 report to the Assistant Secretary and were later approved and implemented to varying degrees. * Recommendation 2006-01: Develop accountability for the Human Capital Plan

189

Quantum physics and human values  

Science Conference Proceedings (OSTI)

This report discusses the following concepts: the quantum conception of nature; the quantum conception of man; and the impact upon human values. (LSP).

Stapp, H.P.

1989-09-01T23:59:59.000Z

190

Bone lead content assessed by L-line x-ray fluorescence in lead-exposed and non-lead-exposed suburban populations in the United States  

SciTech Connect

Measurements of lead (Pb) in bone reflect cumulative Pb exposure, whereas blood Pb levels are indices of absorption during the previous 21-30 days. This study was undertaken to estimate bone Pb concentrations by L-line x-ray fluorescence (LXRF) in a United States suburban population which was exposed to unusually high levels of Pb in emissions from an adjacent factory during 1963-1981, compared with concentrations similarly estimated in a matched suburban community without unusual Pb exposure. The mean bone Pb value in 269 residents of the highly exposed suburb (15 ppm) was 3-fold greater than that of the reference suburb (5 ppm). LXRF estimates of bone Pb identified those individuals at risk for adverse effects of Pb, whereas blood Pb levels were uninformative. Average LXRF-estimated bone Pb concentrations in residents of the unusually exposed suburb approximated estimated values in workers at Pb-processing factories. 44 refs., 1 fig., 1 tab.

Rosen, J.F.; Balbi, K.; Balbi, J.; Bailey, C.; Clemente, I.; Redkey, N.; Grainger, S. (Albert Einstein College of Medicine, Bronx, NY (United States)); Crocetti, A.F. (New York Medical College, Valhalla (United States))

1993-04-01T23:59:59.000Z

191

Simulating human behavior for national security human interactions.  

SciTech Connect

This 3-year research and development effort focused on what we believe is a significant technical gap in existing modeling and simulation capabilities: the representation of plausible human cognition and behaviors within a dynamic, simulated environment. Specifically, the intent of the ''Simulating Human Behavior for National Security Human Interactions'' project was to demonstrate initial simulated human modeling capability that realistically represents intra- and inter-group interaction behaviors between simulated humans and human-controlled avatars as they respond to their environment. Significant process was made towards simulating human behaviors through the development of a framework that produces realistic characteristics and movement. The simulated humans were created from models designed to be psychologically plausible by being based on robust psychological research and theory. Progress was also made towards enhancing Sandia National Laboratories existing cognitive models to support culturally plausible behaviors that are important in representing group interactions. These models were implemented in the modular, interoperable, and commercially supported Umbra{reg_sign} simulation framework.

Bernard, Michael Lewis; Hart, Dereck H.; Verzi, Stephen J.; Glickman, Matthew R.; Wolfenbarger, Paul R.; Xavier, Patrick Gordon

2007-01-01T23:59:59.000Z

192

Human Error in Airway Facilities  

E-Print Network (OSTI)

This report examines human errors in Airway Facilities (AF) with the intent of preventing these errors from being passed on to the new Operations Control Centers. To effectively manage errors, they first have to be identified. Human factors engineers researched human error literature, analyzed human errors recorded in AF databases, and conducted structured interviews with AF representatives. This study enabled them to categorize the types of human errors, identify potential causal factors, and recommend strategies for their mitigation. The results provide preventative measures that designers, developers, and users can take to reduce human error. 17. Key Words Human Error Error Mitigation Operations Control Centers Error Mitigation Strategies 18. Distribution Statement This document is available to the public through the National Technical Information Service, Springfield, Virginia, 22161. 19. Security Classif. (of this report) 20. Security Classif. (of this page) 21. No. of Pages 23 22. Price Form DOT F 1700.7 (8-72) Reproduction of completed page authorized iii ACKNOWLEDGMENTS This research was accomplished under the sponsorship of the Office of Chief Scientist for Human Factors, AAR-100. The research team greatly appreciates the support supplied by Beverly Clark of AOP-30 and our subject matter expert, Kermit Grayson of Grayson Consulting. We also wish to extend our thanks to the people interviewed at the facilities who gave their valuable time in helping us to achieve the goals of our project. iv v Table of Contents Page Acknowledgments..........................................................................................................................iii Executive Summary......................................................................................

Vicki Ahlstrom; Vicki Ahlstrom Act; Donald G. Hartman

2001-01-01T23:59:59.000Z

193

Validation of mutual information-based registration of CT and bone SPECT images in dual-isotope studies  

Science Conference Proceedings (OSTI)

The registration of computed tomography (CT) and nuclear medicine (NM) images can substantially enhance patient diagnosis as it allows for the fusion of anatomical and functional information, as well as the attenuation correction of NM images. However, ... Keywords: Accuracy, Bone SPECT, Dual-isotope studies, Multi-modality registration, Multi-resolution, Mutual information, Precision, Qualitative evaluation, Quantitative validation, Reproducibility, Robustness, Sensitivity

Lisa Tang; Ghassan Hamarneh; Anna Celler

2008-11-01T23:59:59.000Z

194

Human Genome Research: Decoding DNA  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Genome Research: Decoding DNA Human Genome Research: Decoding DNA Resources with Additional Information Charles DeLisi As head of DOE's Office of Health and Environmental Research, Charles DeLisi played a pivotal role in proposing and initiating the Human Genome Program in 1986. The U.S. Department of Energy (DOE) has historically been active in supporting human genome research. On September 10, 2003, Secretary of Energy Spencer Abraham presented the Secretary's Gold Award to Aristides Patrinos and Francis Collins for their leadership of the government's Human Genome Project. At DOE's Office of Science, Dr. Patrinos is the Associate Director for Biological and Environmental Research. He has been a researcher at the department's Oak Ridge National Laboratory and Brookhaven National Laboratory.

195

Alkali-free bioactive glasses for bone tissue engineering: A preliminary investigation  

SciTech Connect

An alkali-free series of bioactive glasses has been designed and developed in the glass system CaO-MgO-SiO2-P2O5-CaF2 along diopside (CaMgSi2O6) – fluorapatite [Ca5(PO4)3F] – tricalcium phosphate (3CaO•P2O5) join. The silicate network in all the investigated glasses is predominantly coordinated in Q2 (Si) units while phosphorus tends to remain in orthophosphate (Q0) environment. The in vitro bioactivity analysis of glasses has been made by immersion of glass powders in simulated body fluid (SBF) while chemical degradation has been studied in Tris-HCl in accordance with ISO-10993-14. Some of the investigated glasses exhibit hydroxyapatite (HA) formation on their surface with in 1-12 h of their immersion in SBF solution. The sintering and crystallization kinetics of glasses has been investigated by differential thermal analysis (DTA) and hot-stage microscopy (HSM), respectively while the crystalline phase evolution in resultant glass-ceramics (GCs) has been studied in the temperature range of 800-900 oC using powder X-ray diffraction (XRD) and scanning electron microscope (SEM). The cell growth and osteogenic differentiation for glasses has been studied in vitro on sintered glass powder compacts using rat bone marrow mesenchymal stem cells. The as designed glasses are ideal candidates for their potential applications in bone tissue engineering in the form of bioactive glasses as well as glass/GC scaffolds.

Goel, Ashutosh; Kapoor, Saurabh; Rajagopal, Raghu R.; Pascual, Maria J.; Kim, Hae-Won; Ferreira, Jose M.

2011-08-25T23:59:59.000Z

196

Dosimetric verification of the anisotropic analytical algorithm in lung equivalent heterogeneities with and without bone equivalent heterogeneities  

SciTech Connect

Purpose: In this study, the authors evaluated the accuracy of dose calculations performed by the convolution/superposition based anisotropic analytical algorithm (AAA) in lung equivalent heterogeneities with and without bone equivalent heterogeneities. Methods: Calculations of PDDs using the AAA and Monte Carlo simulations (MCNP4C) were compared to ionization chamber measurements with a heterogeneous phantom consisting of lung equivalent and bone equivalent materials. Both 6 and 10 MV photon beams of 4x4 and 10x10 cm{sup 2} field sizes were used for the simulations. Furthermore, changes of energy spectrum with depth for the heterogeneous phantom using MCNP were calculated. Results: The ionization chamber measurements and MCNP calculations in a lung equivalent phantom were in good agreement, having an average deviation of only 0.64{+-}0.45%. For both 6 and 10 MV beams, the average deviation was less than 2% for the 4x4 and 10x10 cm{sup 2} fields in the water-lung equivalent phantom and the 4x4 cm{sup 2} field in the water-lung-bone equivalent phantom. Maximum deviations for the 10x10 cm{sup 2} field in the lung equivalent phantom before and after the bone slab were 5.0% and 4.1%, respectively. The Monte Carlo simulation demonstrated an increase of the low-energy photon component in these regions, more for the 10x10 cm{sup 2} field compared to the 4x4 cm{sup 2} field. Conclusions: The low-energy photon by Monte Carlo simulation component increases sharply in larger fields when there is a significant presence of bone equivalent heterogeneities. This leads to great changes in the build-up and build-down at the interfaces of different density materials. The AAA calculation modeling of the effect is not deemed to be sufficiently accurate.

Ono, Kaoru; Endo, Satoru; Tanaka, Kenichi; Hoshi, Masaharu; Hirokawa, Yutaka [Department of Radiation Physics, Hiroshima Heiwa Clinic, 1-31 Kawaramachi, Naka-ku, Hiroshima 730-0856 (Japan); Quantum Energy Applications, Graduate School of Engineering, Hiroshima University, 4-1 Kagamiyama, Higashi-Hiroshima 730-8527 (Japan); Center of Medical Education, Sapporo Medical University, 17 Minami 1 Jo, Chuo-ku, Sapporo 060-8556 (Japan); Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553 (Japan); Department of Radiation Oncology, Hiroshima Heiwa Clinic, 1-31 Kawaramachi, Naka-ku, Hiroshima 730-0856 (Japan)

2010-08-15T23:59:59.000Z

197

Percutaneous Vertebroplasty and Bone Cement Leakage: Clinical Experience with a New High-Viscosity Bone Cement and Delivery System for Vertebral Augmentation in Benign and Malignant Compression Fractures  

Science Conference Proceedings (OSTI)

The aim of this study was to assess the feasibility of and venous leakage reduction in percutaneous vertebroplasty (PV) using a new high-viscosity bone cement (PMMA). PV has been used effectively for pain relief in osteoporotic and malignant vertebral fractures. Cement extrusion is a common problem and can lead to complications. Sixty patients (52 female; mean age, 72.2 {+-} 7.2) suffering from osteoporosis (46), malignancy (12), and angiomas (2), divided into two groups (A and B), underwent PV on 190 vertebrae (86 dorsal, 104 lumbar). In Group A, PV with high-viscosity PMMA (Confidence, Disc-O-Tech, Israel) was used. This PMMA was injected by a proprietary delivery system, a hydraulic saline-filled screw injector. In Group B, a standard low-viscosity PMMA was used. Postprocedural CT was carried out to detect PMMA leakages and complications. Fisher's exact test and Wilcoxon rank test were used to assess significant differences (p PV was feasible, achieving good clinical outcome (p < 0.0001) without major complications. In Group A, postprocedural CT showed an asymptomatic leak in the venous structures of 8 of 98 (8.2%) treated vertebrae; a discoidal leak occurred in 6 of 98 (6.1%). In Group B, a venous leak was seen in 38 of 92 (41.3%) and a discoidal leak in 12 of 92 (13.0%). Reduction of venous leak obtained by high-viscosity PMMA was highly significant (p < 0.0001), whereas this result was not significant (p = 0.14) related to the disc. The high-viscosity PMMA system is safe and effective for clinical use, allowing a significant reduction of extravasation rate and, thus, leakage-related complications.

Anselmetti, Giovanni Carlo, E-mail: giovanni.anselmetti@ircc.i [Institute for Cancer Research and Treatment (IRCC), Interventional Radiology Unit (Italy); Zoarski, Gregg [University of Maryland, Radiology and Radiological Science (United States); Manca, Antonio [Institute for Cancer Research and Treatment (IRCC), Radiology Unit (Italy); Masala, Salvatore [University 'Tor Vergata', Radiology Unit and Interventional Radiology Unit (Italy); Eminefendic, Haris; Russo, Filippo; Regge, Daniele [Institute for Cancer Research and Treatment (IRCC), Radiology Unit (Italy)

2008-09-15T23:59:59.000Z

198

Examining Wari influence in the Las Trancas Valley, Peru using oxygen isotopes from bone carbonate  

E-Print Network (OSTI)

Results. Chemical Geology (Isotope Geosciences Section),isotopes in fossil teeth from Pakistan. Chemical Geology,Isotope Composition of Human Tooth Enamel from Medieval Greenland: Linking Climate with Society: Comment. Geology,

Henry, Erin-Marie Lelik

2008-01-01T23:59:59.000Z

199

Flesh yours, bones mine : the making of the biomedical subject in Turkey  

E-Print Network (OSTI)

With the emergence of biomedical technologies, human body parts from living or dead donors have become commodities in the international networks of trade. This dissertation tries to understand religious, political and ...

Sanal, Aslihan

2005-01-01T23:59:59.000Z

200

Humanized mice with ectopic artificial liver tissues  

E-Print Network (OSTI)

Humanized” mice offer a window into aspects of human physiology that are otherwise inaccessible. The best available methods for liver humanization rely on cell transplantation into immunodeficient mice with liver injury ...

Thomas, David K.

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

A framework for human microbiome research  

E-Print Network (OSTI)

A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project ...

Friedman, Jonathan

202

Human genome. 1993 Program report  

SciTech Connect

The purpose of this report is to update the Human Genome 1991-92 Program Report and provide new information on the DOE genome program to researchers, program managers, other government agencies, and the interested public. This FY 1993 supplement includes abstracts of 60 new or renewed projects and listings of 112 continuing and 28 completed projects. These two reports, taken together, present the most complete published view of the DOE Human Genome Program through FY 1993. Research is progressing rapidly toward 15-year goals of mapping and sequencing the DNA of each of the 24 different human chromosomes.

Not Available

1994-03-01T23:59:59.000Z

203

Strategic Use of Human Capital | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

use of human capital. Strategic Use of Human Capital More Documents & Publications DOE Strategic Human Capital Plan (FY 2011 - 2015) Inspection Report: DOEIG-0888 Human Capital...

204

HVAC Sensors, Controls, and Human Feedback Interfaces  

NLE Websites -- All DOE Office Websites (Extended Search)

HVAC Sensors, HVAC Sensors, Controls, and Human Controls, and Human Feedback Interfaces Feedback Interfaces April 26, 2010 Dr. Amr Gado Emerson Climate Technologies Heating And...

205

Homeland Security/Forensics/Human Identity News  

Science Conference Proceedings (OSTI)

... Humans spend greater than 90 percent of their time indoors, but we ... Experts Recommend Measures to Reduce Human Error in Fingerprint Analysis ...

2010-12-01T23:59:59.000Z

206

ORISE: Human Subjects Research Database  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Subjects Research Database Section 10, Part 745 of the Code of Federal Regulations and U.S. Department of Energy (DOE) Orders 443.1 and 481.1 require the maintenance of...

207

Human Errors in Information Security  

E-Print Network (OSTI)

The purpose of the paper is to target audience and stakeholder individuals whom are in charge of securing the assets of their organisations and institutions. This paper starts by providing a brief overview of information security, outlining the main goals and techniques of the discipline. The paper also discusses the role of human factors and how the information security research community has recognised the increasingly crucial role of human behaviour in many security failures. This is followed by a literature review of human errors in information security. Finally, this paper discusses Reason's Generic Error Modelling System (GEMS) as a potential model for explaining human errors in information security [18]. The terms computer security, network security and information security are used interchangeably in this paper.

Munir Ahmed; Lukman Sharif; Muhammad Kabir; Maha Al-maimani

2012-01-01T23:59:59.000Z

208

Coördinating human-robot communication  

E-Print Network (OSTI)

As robots begin to emerge from the cloisters of industrial and military applications and enter the realms of coöperative partners for people, one of the most important facets of human-robot interaction (HRI) will be ...

Brööks, Andrëw G. (Brööks Zoz)

2007-01-01T23:59:59.000Z

209

Human Factors Engineering Analysis Tool  

A new software tool enables the easy and quick selection of applicable regulatory guidelines as a starting point for human factors engineering (HFE) analyses.  Once selected, each guideline can be viewed on screen.  The software tracks and reports the ...

210

Human Genome Education Program  

Science Conference Proceedings (OSTI)

The funds from the DOE Human Genome Program, for the project period 2/1/96 through 1/31/98, have provided major support for the curriculum development and field testing efforts for two high school level instructional units: Unit 1, ''Exploring Genetic Conditions: Genes, Culture and Choices''; and Unit 2, ''DNA Snapshots: Peaking at Your DNA''. In the original proposal, they requested DOE support for the partial salary and benefits of a Field Test Coordinator position to: (1) complete the field testing and revision of two high school curriculum units, and (2) initiate the education of teachers using these units. During the project period of this two-year DOE grant, a part-time Field-Test Coordinator was hired (Ms. Geraldine Horsma) and significant progress has been made in both of the original proposal objectives. Field testing for Unit 1 has occurred in over 12 schools (local and non-local sites with diverse student populations). Field testing for Unit 2 has occurred in over 15 schools (local and non-local sites) and will continue in 12-15 schools during the 96-97 school year. For both curricula, field-test sites and site teachers were selected for their interest in genetics education and in hands-on science education. Many of the site teachers had no previous experience with HGEP or the unit under development. Both of these first-year biology curriculum units, which contain genetics, biotechnology, societal, ethical and cultural issues related to HGP, are being implemented in many local and non-local schools (SF Bay Area, Southern California, Nebraska, Hawaii, and Texas) and in programs for teachers. These units will reach over 10,000 students in the SF Bay Area and continues to receive support from local corporate and private philanthropic organizations. Although HGEP unit development is nearing completion for both units, data is still being gathered and analyzed on unit effectiveness and student learning. The final field testing result from this analysis will contribute to the final revisions of each unit during the second-year of this grant.

Richard Myers; Lane Conn

2000-05-01T23:59:59.000Z

211

Celebrating Excellence in Humanities 2012 Celebrating Excellence in Humanities 2012 Celebrating Excellence in Humanities 2012  

E-Print Network (OSTI)

-1950" Brian Catlos History University of Texas at Arlington 47th Annual Walter Prescott Webb Essay Competition. Guerrero Literature/Creative Writing Humanities Undergraduate Research Award "I Once Was Lost: The (Found

California at Santa Cruz, University of

212

A Signal-Inducing Bone Cement for Magnetic Resonance Imaging-Guided Spinal Surgery Based on Hydroxyapatite and Polymethylmethacrylate  

Science Conference Proceedings (OSTI)

The aim of this study was to develop a signal-inducing bone cement for magnetic resonance imaging (MRI)-guided cementoplasty of the spine. This MRI cement would allow precise and controlled injection of cement into pathologic lesions of the bone. We mixed conventional polymethylmethacrylate bone cement (PMMA; 5 ml methylmethacrylate and 12 g polymethylmethacrylate) with hydroxyapatite (HA) bone substitute (2-4 ml) and a gadolinium-based contrast agent (CA; 0-60 {mu}l). The contrast-to-noise ratio (CNR) of different CA doses was measured in an open 1.0-Tesla scanner for fast T1W Turbo-Spin-Echo (TSE) and T1W TSE pulse sequences to determine the highest signal. We simulated MRI-guided cementoplasty in cadaveric spines. Compressive strength of the cements was tested. The highest CNR was (1) 87.3 (SD 2.9) in fast T1W TSE for cements with 4 {mu}l CA/ml HA (4 ml) and (2) 60.8 (SD 2.4) in T1W TSE for cements with 1 {mu}l CA/ml HA (4 ml). MRI-guided cementoplasty in cadaveric spine was feasible. Compressive strength decreased with increasing amounts of HA from 46.7 MPa (2 ml HA) to 28.0 MPa (4 ml HA). An MRI-compatible cement based on PMMA, HA, and CA is feasible and clearly visible on MRI images. MRI-guided spinal cementoplasty using this cement would permit direct visualization of the cement, the pathologic process, and the anatomical surroundings.

Wichlas, Florian, E-mail: florian.wichlas@charite.de; Seebauer, Christian J.; Schilling, Rene [University Charite, Center for Musculoskeletal Surgery (Germany); Rump, Jens [University Charite, Department of Radiology (Germany); Chopra, Sascha S. [University Charite, Center for Musculoskeletal Surgery (Germany); Walter, Thula; Teichgraeber, Ulf K. M. [University Charite, Department of Radiology (Germany); Bail, Hermann J. [University Charite, Center for Musculoskeletal Surgery (Germany)

2012-06-15T23:59:59.000Z

213

FTCP Human Factors Engineering Supplemental Competencies  

Energy.gov (U.S. Department of Energy (DOE))

Human Factors Engineering Functional Area Qualification Competencies Examples for DOE Defense Nuclear Facilities Technical Personnel

214

Five design challenges for human computation  

Science Conference Proceedings (OSTI)

Human computation systems, which draw upon human competencies in order to solve hard computational problems, represent a growing interest within HCI. Despite the numerous technical demonstrations of human computation systems, however, there are few design ... Keywords: citizen science, crowdsourcing, design framework, games with a purpose, human computation

Stuart Reeves; Scott Sherwood

2010-10-01T23:59:59.000Z

215

Innovative Composites Through Reinforcement Morphology Design - a Bone-Shaped-Short-Fiber Composite  

Science Conference Proceedings (OSTI)

This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at Los Alamos National Laboratory (LANL). The objective of this project is to improve the strength and toughness of conventional short-fiber composites by using innovative bone-shaped-short (BSS) fibers as reinforcement. We fabricated a model polyethylene BSS fiber-reinforced polyester-matrix composite to prove that fiber morphology, instead of interfacial strength, solves the problem. Experimental tensile and fracture toughness test results show that BSS fibers can bridge matrix cracks more effectively, and consume many times more energy when pulled out, than conventional-straight-short (CSS) fibers. This leads to both higher strength and fracture toughness for the BSS-fiber composites. A computational model was developed to simulate crack propagation in both BSS- and CSS-fiber composites, accounting for stress concentrations, interface debonding, and fiber pullout. Model predictions were validated by experimental results and will be useful in optimizing BSS-fiber morphology and other material system parameters.

Zhu, Y.T.; Valdez, J.A.; Beyerlain, I.J.; Stout, M.G.; Zhou, S.; Shi, N.; Lowe, T.C.

1999-06-29T23:59:59.000Z

216

Human Capital Management | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Human Capital Management Human Capital Management Human Capital Management The strategic management of human capital requires comprehensive planning and analysis in order to develop, implement, and evaluate programs that support every facet of employee work life. DOE human capital initiatives are designed to support continuous improvement and accountability in accordance with the DOE Human Capital Management Accountability Program (HCMAP), which is an internal DOE audit process of servicing human resources offices and addresses those documents that require coordination with the Office of the Chief Human Capital Officer before being implemented; Human Resource Directors; the Department's 5-year Strategic Human Capital Management Plan; Departmental element workforce plans; the Department's personnel accountability program that is used

217

Characterization of the Bone Loss and Recovery Response at the Distal Femur Metaphysis of the Adult Male Hindlimb Unloaded Rat  

E-Print Network (OSTI)

Extended periods of mechanical unloading are known to be detrimental to bone health. Astronauts who spend months in microgravity aboard the International Space Station (ISS) are at particular risk. It is anticipated that NASA will not drastically increase the size of the astronaut corps, and this will mean increased likelihood of repeat missions for more astronauts. Thus, it is important to better understand the effects that prolonged, multiple bouts of unloading have on bone. This study utilized the hindlimb unloaded (HU) rat model to examine bone loss and recovery for single and double unloading bouts. Adult male Sprague-Dawley rats (6 months old) were randomized into the following groups: baseline (sacrificed at 6 months), 1HU7 (unloaded for 1 month, weight-bearing recovery for 3 months), 2HU10 (unloaded for 1 month, recovered for 2 months, unloaded for another month, and then recovered 2 months), 1HU10 (normal cage activity until 1 month HU ending at month 10, 2 month recovery followed), and aging controls (remained ambulatory throughout experiment). Every month (28 days), animals were terminated and the left femurs were excised, resulting in n=15 per group for each time point. Mineral and geometric properties were measured using peripheral quantitative computed tomography (pQCT) at the distal femur metaphysis, and quasi-static reduced platen compression (RPC) was used to estimate the mechanical properties of cancellous bone. Strength indices based on pQCT parameters were calculated as predictors of mechanical properties. Bone mass properties decreased due to HU and recovered within 2-3 months post-HU. A combination of increased periosteal apposition and endocortical resorption also occurred during HU. The initial HU bout suppressed normal age-related increases in mechanical properties and recovered within 1-2 months. Cancellous compressive strength index (CSI) most closely matched changes in mechanical properties. A second HU bout after two months recovery had a less detrimental effect on pQCT parameters but a greater negative impact on mechanical properties, when compared to pre-HU values. The opposite is true for mechanical properties if loss is characterized relative to aging controls. Recovery after the second HU period did not appear to be significantly affected by a previous bout of HU.

Davis, Joshua Morgan

2011-12-01T23:59:59.000Z

218

Human gene sequencing makes advances  

SciTech Connect

The Human Genome Project is a federal project that is on the scale of the Manhattan Project of the 1940s. The focus of this project is to map and sequence the 100,000 plus genes and 3 billion base pairs that comprise the human genome. This effort has made two recent advances. First, two of the major companies involved in this project formed a strategic alliance that will pump up to 125 million dollars into this project. Second, researchers at Argonne National Lab. have tested a new sequencing technique that could identify 100 million base pairs a day when fully implemented.

Alper, J.

1993-09-01T23:59:59.000Z

219

Evolutionarily conserved sequences on human chromosome 21  

SciTech Connect

Comparison of human sequences with the DNA of other mammals is an excellent means of identifying functional elements in the human genome. Here we describe the utility of high-density oligonucleotide arrays as a rapid approach for comparing human sequences with the DNA of multiple species whose sequences are not presently available. High-density arrays representing approximately 22.5 Mb of nonrepetitive human chromosome 21 sequence were synthesized and then hybridized with mouse and dog DNA to identify sequences conserved between humans and mice (human-mouse elements) and between humans and dogs (human-dog elements). Our data show that sequence comparison of multiple species provides a powerful empiric method for identifying actively conserved elements in the human genome. A large fraction of these evolutionarily conserved elements are present in regions on chromosome 21 that do not encode known genes.

Frazer, Kelly A.; Sheehan, John B.; Stokowski, Renee P.; Chen, Xiyin; Hosseini, Roya; Cheng, Jan-Fang; Fodor, Stephen P.A.; Cox, David R.; Patil, Nila

2001-09-01T23:59:59.000Z

220

Human and unhuman commonsense reasoning  

Science Conference Proceedings (OSTI)

Ford has introduced a non-monotonic logic, System LS, inspired by an empirical study of human non-monotonic reasoning. We define here a defeasible logic FDL based on Fordh's logic, and in doing so identify some similarities and differences between Ford's ...

Michael J. Maher

2010-10-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

A Literary Human Exinction Scenario  

Science Conference Proceedings (OSTI)

Mary Wollstonecraft Shelly's (MWS) novel, The Last Man, published in 1826, is an epic narrative about the destruction of the human race. This paper provides a synopsis of this book and assesses its relationships to contemporary future studies. The paper also delves into the history of apocalyptic writing and thinking, using this book an entry point to past literature.

Tonn, Bruce Edward [ORNL

2009-11-01T23:59:59.000Z

222

The human agent virtual environment  

Science Conference Proceedings (OSTI)

In this paper we describe a multi-agent simulation called the Human Agent Virtual Environment (or HAVE). HAVE is a test bed to explore agent-environment interaction in multi-agent simulation for defence applications. The primary research driver in the ... Keywords: agents and cognitive models, defence, multi-agent simulation and modeling

Michael Papasimeon; Adrian R. Pearce; Simon Goss

2007-05-01T23:59:59.000Z

223

Human retroviruses and AIDS 1994  

SciTech Connect

This compendium, including accompanying floppy diskettes, is the result of an effort to compile and rapidly publish all relevant molecular data concerning the human immunodeficiency viruses (HIV) and related retroviruses. The scope of the compendium and database is best summarized by the five parts it comprises: (I) Nucleic Acid Alignments and Sequences; (II) Amino Acid Alignments; (III) Analysis; (IV) Related Sequences; (V) Database communications.

Myers, G.; Korber, B. [Los Alamos National Lab., NM (United States); Wain-Hobson, S.; Jeang, Kuan-Teh; Henderson, L.E.; Pavlakis, G.N. [eds.

1995-01-01T23:59:59.000Z

224

Human-Machine Function Allocation  

Science Conference Proceedings (OSTI)

Table 1   Human-machine function comparison...ability Comparatively slow and poor computers. Excellent and very rapid computers. Memory storage Poor short-term storage. Excellent long-term storage. Excellent short-term storage. Long-term storage very

225

Patterns of Practice in Palliative Radiotherapy for Painful Bone Metastases: A Survey in Japan  

Science Conference Proceedings (OSTI)

Purpose: To determine the current patterns of practice in Japan and to investigate factors that may make clinicians reluctant to use single-fraction radiotherapy (SF-RT). Methods and Materials: Members of the Japanese Radiation Oncology Study Group (JROSG) completed an Internet-based survey and described the radiotherapy dose fractionation they would recommend for four hypothetical cases describing patients with painful bone metastasis (BM). Case 1 described a patient with an uncomplicated painful BM in a non-weight-bearing site from non-small-cell lung cancer. Case 2 investigated whether management for a case of uncomplicated spinal BM would be different from that in Case 1. Case 3 was identical with Case 2 except for the presence of neuropathic pain. Case 4 investigated the prescription for an uncomplicated painful BM secondary to oligometastatic breast cancer. Radiation oncologists who recommended multifraction radiotherapy (MF-RT) for Case 2 were asked to explain why they considered MF-RT superior to SF-RT. Results: A total of 52 radiation oncologists from 50 institutions (36% of JROSG institutions) responded. In all four cases, the most commonly prescribed regimen was 30 Gy in 10 fractions. SF-RT was recommended by 13% of respondents for Case 1, 6% for Case 2, 0% for Case 3, and 2% for Case 4. For Case 4, 29% of respondents prescribed a high-dose MF-RT regimen (e.g., 50 Gy in 25 fractions). The following factors were most often cited as reasons for preferring MF-RT: 'time until first increase in pain' (85%), 'incidence of spinal cord compression' (50%), and 'incidence of pathologic fractures' (29%). Conclusions: Japanese radiation oncologists prefer a schedule of 30 Gy in 10 fractions and are less likely to recommend SF-RT. Most Japanese radiation oncologists regard MF-RT as superior to SF-RT, based primarily on the time until first increase in pain.

Nakamura, Naoki, E-mail: naokinak@luke.or.jp [Department of Radiation Oncology, St. Luke's International Hospital, Tokyo (Japan); Shikama, Naoto [Department of Radiation Oncology, Saitama Medical University International Medical Center, Hidaka (Japan); Wada, Hitoshi [Department of Radiation Oncology, Miyagi Cancer Center, Natori (Japan); Harada, Hideyuki [Division of Radiation Oncology, Shizuoka Cancer Center, Mishima (Japan); Nozaki, Miwako [Department of Radiology, Dokkyo Medical University Koshigaya Hospital, Koshigaya (Japan); Nagakura, Hisayasu [Department of Radiology, KKR Sapporo Medical Center, Sapporo (Japan); Tago, Masao [Department of Radiology, Teikyo University Mizonokuchi Hospital, Kawasaki (Japan); Oguchi, Masahiko [Department of Radiation Oncology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo (Japan); Uchida, Nobue [Department of Radiation Oncology, Shimane University Hospital, Izumo (Japan)

2012-05-01T23:59:59.000Z

226

A tribological and biomimetic study of potential bone joint repair materials  

E-Print Network (OSTI)

This research investigates materials for bone-joint failure repair using tribological and biomimicking approaches. The materials investigated represent three different repairing strategies. Refractory metals with and without treatment are candidates for total joint replacements due to their mechanical strength, high corrosion resistance and biocompatibility. A composite of biodegradable polytrimethylene carbonate, hydroxyl apatite, and nanotubes was investigated for application as a tissue engineering scaffold. Non-biodegradable polymer polyimide combined with various concentrations of nanotubes was investigated as a cartilage replacement material. A series of experimental approaches were used in this research. These include analysis of material surfaces and debris using high-resolution techniques and tribological experiments, as well as evaluation of nanomechanical properties. Specifically, the surface structure and wear mechanisms were investigated using a scanning electron microscope and an atomic force microscope. Debris morphology and structure was investigated using a transmission electron microscope. The debris composition was analyzed using an X-ray diffractometer. Nanoindentation was incorporated to investigate the surface nanomechanical properties. Polytrimythelene carbonate combined with hydroxyapatite and nanotubes exhibited a friction coefficient lower than UHMWPE. The nanoindentation response mimicked cartilage more closely than UHMWPE. A composite formed with PI and nanotubes showed a varying friction coefficient and varying nanoindentation response with variation in nanotube concentration. Low friction coefficients corresponded with low modulus values. A theory was proposed to explain this behavior based on surface interactions between nanotubes and between nanotubes and PI. A model was developed to simulate the modulus as a function of nanotube concentration. The boronized refractory metals exhibited brittleness and cracking. Higher friction coefficients were associated with the formation of amorphous debris. The friction coefficient for boronized Cr (~0.06) under simulated body fluid conditions was in the range found in natural joints.

Ribeiro, Rahul

2006-12-01T23:59:59.000Z

227

Contractor Human Resources | National Nuclear Security Administration  

NLE Websites -- All DOE Office Websites (Extended Search)

Contractor Human Resources | National Nuclear Security Administration Contractor Human Resources | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Contractor Human Resources Home > About Us > Our Operations > Acquisition and Project Management > Contractor Human Resources Contractor Human Resources Welcome The Contractor Human Resources mission is to provide expert advice and

228

Mathematical model for predicting the probability of acute mortality in a human population exposed to accidentally released airborne radionuclides. Final report for Phase I  

SciTech Connect

A mathematical model was constructed for the purpose of predicting the fraction of human population which would die within 1 year of an accidental exposure to airborne radionuclides. The model is based on data from laboratory experiments with rats, dogs and baboons, and from human epidemiological data. Doses from external, whole-body irradiation and from inhaled, alpha- and beta-emitting radionuclides are calculated for several organs. The probabilities of death from radiation pneumonitis and from bone marrow irradiation are predicted from doses accumulated within 30 days of exposure to the radioactive aerosol. The model is compared with existing similar models under hypothetical exposure conditions. Suggestions for further experiments with inhaled radionuclides are included. 25 refs., 16 figs., 13 tabs.

Filipy, R.E.; Borst, F.J.; Cross, F.T.; Park, J.F.; Moss, O.R.; Roswell, R.L.; Stevens, D.L.

1980-05-01T23:59:59.000Z

229

Human radiation studies: Remembering the early years: Oral history of radiation biologist Marvin Goldman, Ph.D., conducted December 22, 1994  

SciTech Connect

This report provides a transcript of an interview of Dr. Marvin Goldman by representatives of DOE`s Office of Human Radiation Experiments. Dr. Goldman was chosen for this interview because of his work on bone-seeking radionuclides. After a brief biographical sketch Dr. Goldman related his experiences concerning his training and work at Rochester University, his work at Brookhaven National Laboratory, his participation in the Beagle Studies at University of California at Davis, his work with the Chernobyl Nuclear Plant Accident, his consultation work with Russian authorities on the health and ecological effects in their history, and finally his opinions and recommendations on human radiation research and the environmental cleanup of DOE sites.

1995-09-01T23:59:59.000Z

230

Cloning humans, increasing intelligence, and AIDS money  

NLE Websites -- All DOE Office Websites (Extended Search)

Cloning humans, increasing intelligence, and AIDS money Name: Eric T Jenes Status: NA Age: NA Location: NA Country: NA Date: NA Question: How close are we to cloning humans?...

231

Bioscience & Health Homeland Security/Forensics/Human ...  

Science Conference Proceedings (OSTI)

... vehicle Experts Recommend Measures to Reduce Human Error in Fingerprint Analysis. 13DO003_oles_fingerprintmap_CS ...

2013-05-02T23:59:59.000Z

232

Human Errors: Disadvantages and Advantages  

E-Print Network (OSTI)

The traditional paradigm for learning and training of operators in complex systems is discussed and criticised to react on the strong influence (the doctrine of 'mental logic') coming from research carried out in artificial intelligence (AI). The most well known arguments against the AI-approach are presented and discussed in relation to expertise, intuition and implicit knowledge. The importance of faults and errors are discussed in the context of a new metaphor for cognitive structures to describe expertise, and how knowledge about unsuccessful behavior influences the actual decision making process of experts. Keywords: human error, meta learning, mental model, experience, expertise 1. INTRODUCTION Why is this type of statements "I learned more from my defeats than from my victories" (Napoleon, ca. 1819) sometimes (or always) true? To answer this question we need a new understanding of human errors, inefficient behavior, and expertise. In this paper we will discuss the importance of...

Matthias Rauterberg; Daniel Felix

1996-01-01T23:59:59.000Z

233

Computer (and Human) Perfection at Checkers  

Science Conference Proceedings (OSTI)

In 1989 the Chinook project began with the goal of winning the human World Checkers Championship. There was an imposing obstacle to success ?the human champion, Marion Tinsley. Tinsley was as close to perfection at the game as was humanly possible. To ...

Jonathan Schaeffer

2009-05-01T23:59:59.000Z

234

From here to human-level AI  

Science Conference Proceedings (OSTI)

Human-level AI will be achieved, but new ideas are almost certainly needed, so a date cannot be reliably predicted-maybe five years, maybe five hundred years. I'd be inclined to bet on this 21st century. It is not surprising that human-level AI has proved ... Keywords: Elaboration tolerance, Human-level AI

John McCarthy

2007-12-01T23:59:59.000Z

235

Human activities recognition using depth images  

Science Conference Proceedings (OSTI)

We present a new method to classify human activities by leveraging on the cues available from depth images alone. Towards this end, we propose a descriptor which couples depth and spatial information of the segmented body to describe a human pose. Unique ... Keywords: depth image segmentation, human activity detection

Raj Gupta; Alex Yong-Sang Chia; Deepu Rajan

2013-10-01T23:59:59.000Z

236

Human radiation studies: Remembering the early years. Oral history of Oncologist Helen Vodopick, M.D., December 28, 1994  

SciTech Connect

This report is a transcript of an interview with Dr. Helen Vodopick by representatives of the US DOE Office of Human Radiation Experiments. Dr. Vodopick was chosen for this interview because of her involvement with the Oak Ridge Institute of Nuclear Studies (ORINS) and Oak Ridge Associated Universities (ORAU) experimental cancer-therapy program involving total-body irradiation. After a short biographical sketch Dr. Vodopick relates her remembrances of the Medium-Exposure-Rate Total Body Irradiator (METBI), ORINS radioisotope tracer studies, treatment of cancer patients with the METBI, radiation treatment for leukemia patients, bone marrow treatment of leukemia, the Low-Exposure-Rate Total Body Irradiation (LETBI), treatment of radiation accident victims at ORAU, research with radioactive phosphorus and sulfur, and public opinion issues.

1995-08-01T23:59:59.000Z

237

Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment  

Science Conference Proceedings (OSTI)

The aim of this study was to determine whether intravenously administered multipotent stromal cells from human bone marrow (hMSCs) can improve cardiac function after myocardial infarction (MI) without long-term engraftment and therefore whether transitory paracrine effects or secreted factors are responsible for the benefit conferred. hMSCs were injected systemically into immunodeficient mice with acute MI. Cardiac function and fibrosis after MI in the hMSC-treated group were significantly improved compared with controls. However, despite the cardiac improvement, there was no evident hMSC engraftment in the heart 3 weeks after MI. Microarray assays and ELISAs demonstrated that multiple protective factors were expressed and secreted from the hMSCs in culture. Factors secreted by hMSCs prevented cell death of cultured cardiomyocytes and endothelial cells under conditions that mimicked tissue ischemia. The favorable effects of hMSCs appear to reflect the impact of secreted factors rather than engraftment, differentiation, or cell fusion.

Iso, Yoshitaka [Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States); Cardiovascular Research Institute, Department of Medicine, University of Vermont, 208 South Park Drive, Colchester, VT 05446 (United States); Spees, Jeffrey L. [Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States); Cardiovascular Research Institute, Department of Medicine, University of Vermont, 208 South Park Drive, Colchester, VT 05446 (United States); E-mail: Jeffrey.Spees@uvm.edu; Serrano, Claudia [Section of Cardiology, Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States); Bakondi, Benjamin [Cardiovascular Research Institute, Department of Medicine, University of Vermont, 208 South Park Drive, Colchester, VT 05446 (United States); Pochampally, Radhika [Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States); Song, Yao-Hua [Section of Cardiology, Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States); Sobel, Burton E. [Cardiovascular Research Institute, Department of Medicine, University of Vermont, 208 South Park Drive, Colchester, VT 05446 (United States); Delafontaine, Patrick [Section of Cardiology, Department of Medicine, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States); Prockop, Darwin J. [Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112 (United States)]. E-mail: dprocko@tulane.edu

2007-03-16T23:59:59.000Z

238

Integrating Human Performance and Technology  

Science Conference Proceedings (OSTI)

Human error is a significant factor in the cause and/or complication of events that occur in the commercial nuclear industry. In recent years, great gains have been made using Human Performance (HU) tools focused on targeting individual behaviors. However, the cost of improving HU is growing and resistance to add yet another HU tool certainly exists, particularly for those tools that increase the paperwork for operations. Improvements in HU that are the result of leveraging existing technology, such as hand-held mobile technologies, have the potential to reduce human error in controlling system configurations, safety tag-outs, and other verifications. Operator rounds, valve line-up verifications, containment closure verifications, safety & equipment protection, and system tagging can be supported by field-deployable wireless technologies. These devices can also support the availability of critical component data in the main control room and other locations. This research pilot project reviewing wireless hand-held technology is part of the Light Water Reactor Sustainability Program (LWRSP), a research and development (R&D) program sponsored by the U. S. Department of Energy (DOE). The project is being performed in close collaboration with industry R&D programs to provide the technical foundations for licensing, and managing the long-term, safe, and economical operation of current nuclear power plants. The LWRSP vision is to develop technologies and other solutions that can improve the reliability, sustain the safety, and extend the life of the current nuclear reactor fleet.

Ronald K. Farris; Heather Medema

2012-05-01T23:59:59.000Z

239

Limited Chemotherapy and Shrinking Field Radiotherapy for Osteolymphoma (Primary Bone Lymphoma): Results From the Trans-Tasman Radiation Oncology Group 99.04 and Australasian Leukaemia and Lymphoma Group LY02 Prospective Trial;Bone; Lymphoma; Radiotherapy; Chemotherapy; Clinical trial  

SciTech Connect

Purpose: To establish benchmark outcomes for combined modality treatment to be used in future prospective studies of osteolymphoma (primary bone lymphoma). Methods and Materials: In 1999, the Trans-Tasman Radiation Oncology Group (TROG) invited the Australasian Leukemia and Lymphoma Group (ALLG) to collaborate on a prospective study of limited chemotherapy and radiotherapy for osteolymphoma. The treatment was designed to maintain efficacy but limit the risk of subsequent pathological fractures. Patient assessment included both functional imaging and isotope bone scanning. Treatment included three cycles of CHOP chemotherapy and radiation to a dose of 45 Gy in 25 fractions using a shrinking field technique. Results: The trial closed because of slow accrual after 33 patients had been entered. Accrual was noted to slow down after Rituximab became readily available in Australia. After a median follow-up of 4.3 years, the five-year overall survival and local control rates are estimated at 90% and 72% respectively. Three patients had fractures at presentation that persisted after treatment, one with recurrent lymphoma. Conclusions: Relatively high rates of survival were achieved but the number of local failures suggests that the dose of radiotherapy should remain higher than it is for other types of lymphoma. Disability after treatment due to pathological fracture was not seen.

Christie, David, E-mail: david.christie@premion.com.au [Premion and Bond University, Gold Coast, Queensland (Australia); Dear, Keith [Department of Epidemiology and Population Studies, Australian National University, Canberra, New South Wales (Australia); Le, Thai [BHB, Premion, Brisbane, Queensland (Australia); Barton, Michael [Collaboration for Cancer Outcomes and Research (CCORE) and University of NSW, Sydney, New South Wales (Australia); Wirth, Andrew [Peter MacCallum Cancer Institute, Melbourne, Victoria (Australia); Porter, David [Auckland Hospital, Auckland (New Zealand); Roos, Daniel [Royal Adelaide Hospital, Adelaide, South Australia (Australia); Pratt, Gary [Royal Brisbane Hospital, Brisbane, Queensland (Australia)

2011-07-15T23:59:59.000Z

240

Human Reliability Analysis for Design: Using Reliability Methods for Human Factors Issues  

SciTech Connect

This paper reviews the application of human reliability analysis methods to human factors design issues. An application framework is sketched in which aspects of modeling typically found in human reliability analysis are used in a complementary fashion to the existing human factors phases of design and testing. The paper provides best achievable practices for design, testing, and modeling. Such best achievable practices may be used to evaluate and human system interface in the context of design safety certifications.

Ronald Laurids Boring

2010-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
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241

Climate Human Capital | Open Energy Information  

Open Energy Info (EERE)

Climate Human Capital Climate Human Capital Jump to: navigation, search Name Climate Human Capital Place London, United Kingdom Zip W1K 6NG Sector Carbon, Renewable Energy, Services Product Green executive search company, listed in London's PLUS marketplace since 30 MArch 2010, focusing on the following target sectors: Carbon Markets, Environmental Sciences, Research and Advisory, Financial Services, Renewable Energy Generation and Policy. References Climate Human Capital[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Climate Human Capital is a company located in London, United Kingdom . References ↑ "Climate Human Capital" Retrieved from "http://en.openei.org/w/index.php?title=Climate_Human_Capital&oldid=343709

242

Scale-Free Cortical Planar Networks  

E-Print Network (OSTI)

D [2004] The modeling of scale-free networks. Physica A 333:Synchronization in scale-free dynamical networks: Robustnessnetworks: small-world, scale-free and beyond. IEEE Trans

Freeman, Walter J III; Kozma, Robert; Bollobás, Béla; Riordan, Oliver

2009-01-01T23:59:59.000Z

243

Comparison of the Distributions of Bromine, Lead and Zinc in Tooth and Bone from an Ancient Peruvian Burial site by X-ray Fluorescence  

SciTech Connect

Synchrotron micro X-ray fluorescence was used to study the distribution of selected trace elements (Zn, Pb, and Br) in tooth and bone samples obtained from an individual from a pre-Columbian archaeological site (Cabur) located on the north coast of Peru. The results show that Zn, Pb, and Br are present in both the teeth and bone samples and that the Zn and Pb seem to be confined to similar regions (cementum and periostium), while Br shows a novel distribution with enrichment close to the Haversian canals and (or) in regions that appear to be Ca deficient.

Martin,R.; Naftel, S.; Nelson, A.; Sapp, W.

2007-01-01T23:59:59.000Z

244

DOE O 328.1, Human Capital Management Accountability Program  

Directives, Delegations, and Requirements

The Order establishes requirements, roles and responsibilities for the Human Capital Management Accountability Program (HCMAP) for human resources programs and ...

2008-08-01T23:59:59.000Z

245

Human Resources & Occupational Medicine  

NLE Websites -- All DOE Office Websites (Extended Search)

Job Opportunities Benefits Office • Work-Life Balance Programs • International Services • Occupational Medicine • Salaries & Awards • Training & Qualifications The Human Resources and Occupational Medicine Division handles scientific and non-scientific employment, benefits, employee and labor relations, staff development, salaries and awards, employee records, and occupational medicine. For more information, click on the one of the services listed above. Brookhaven National Laboratory has a long-standing commitment to a policy of equal opportunity and diversity. Our goal is equality of opportunity in all aspects of employment, including placement, development programs, job assignments, transfers and promotions, without regard to race, color,

246

Simulation of human decision making  

DOE Patents (OSTI)

A method for computer emulation of human decision making defines a plurality of concepts related to a domain and a plurality of situations related to the domain, where each situation is a combination of at least two of the concepts. Each concept and situation is represented in the computer as an oscillator output, and each situation and concept oscillator output is distinguishable from all other oscillator outputs. Information is input to the computer representative of detected concepts, and the computer compares the detected concepts with the stored situations to determine if a situation has occurred.

Forsythe, J. Chris (Sandia Park, NM); Speed, Ann E. (Albuquerque, NM); Jordan, Sabina E. (Albuquerque, NM); Xavier, Patrick G. (Albuquerque, NM)

2008-05-06T23:59:59.000Z

247

Guessing human-chosen secrets  

E-Print Network (OSTI)

Guessing human-chosen secrets Joseph Bonneau University of Cambridge Churchill College May 2012 This dissertation is submitted for the degree of Doctor of Philosophy Declaration This dissertation is the result of my own work and includes nothing... , including tables and footnotes. To Fletcher, for teaching me the value of hard work. I’m glad you’re back. —Joseph Bonneau, May 2012 Acknowledgements I am grateful to my supervisor Ross Anderson for help every step of the way, from answering my emails when I...

Bonneau, Joseph

2012-06-12T23:59:59.000Z

248

Human exposure through food chains:  

Science Conference Proceedings (OSTI)

Using information collected under the community right to know'' provision of the Superfund reauthorization act, the US Environmental Protection Agency has revealed that some two to three billion pounds of toxic chemicals are released annually to the atmosphere from industries in the US. Human populations can contact these environmental pollutants through food, water, and air in varying amounts each day throughout a lifetime. A realistic strategy for managing the potential health risks of industrial emissions requires a comprehensive approach with adequate attention to uncertainties. Using contaminant transfers from air to milk and as a case study, I consider here two important issues in exposure assessment --- (1) estimation of and (2) reduction of uncertainty in exposure estimates. This case study provides a distinction between variability, ignorance and uncertainty. For the air/milk pathways, I explore the use of exposure models that combine information on environmental partitioning with data on human diet, behavior patterns, and physiology into a numerical expression that links ambient air concentrations with chronic daily intake. I examine how uncertainty limits current exposure modeling efforts and suggest research to reduce these uncertainty. 17 refs., 12 figs., 1 tab.

McKone, T.E.

1990-02-01T23:59:59.000Z

249

Human Resources | National Nuclear Security Administration  

National Nuclear Security Administration (NNSA)

Human Resources | National Nuclear Security Administration Human Resources | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Human Resources Home > About Us > Our Operations > Management and Budget > Human Resources Human Resources The Human Resources function in NNSA is a vital partnership between all levels of NNSA management. It requires effective collaboration with the

250

Human Resources | National Nuclear Security Administration  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Resources | National Nuclear Security Administration Human Resources | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Human Resources Home > About Us > Our Operations > Management and Budget > Human Resources Human Resources The Human Resources function in NNSA is a vital partnership between all levels of NNSA management. It requires effective collaboration with the

251

PROLONGED STUDIES OF CHANGES OF THE COMPOSITION OF THE PERIPHERAL BLOOD AND BONE MARROW IN ANIMALS FOLLOWING WHOLE-BODY SINGLE X IRRADIATION  

SciTech Connect

The changes in the composition of the peripheral blood and the bone marrow in cats following a single whole-body dose of 300 r x radiation were studied over a period of 715 days. The data are tabulated. (J.S.R.)

Tkacheva, T.V.

1959-03-01T23:59:59.000Z

252

Health Information Technology (IT), Human Factor Guidelines  

Science Conference Proceedings (OSTI)

... on a research program aimed at developing human factors guidelines for ... technical guidelines will help support safe, effective, error-free EHR use ...

2013-08-05T23:59:59.000Z

253

Automatic Recognition of Human Team Behaviors  

E-Print Network (OSTI)

This paper describes a methodology for recording, representing, and recognizing team behaviors performed by human players in an Unreal Tournament MOUT (Military Operations in Urban Terrain) scenario.

Gita Sukthankar; Katia Sycara

2005-01-01T23:59:59.000Z

254

Improving human forensics through advances in genetics ...  

Science Conference Proceedings (OSTI)

... 98. Liu, B. et al. Expression of membrane-associated mucins MUC1 and MUC4 in major human salivary glands. J. Histochem. Cytochem. ...

2012-10-09T23:59:59.000Z

255

Apparatus and methods for a human extender  

SciTech Connect

A human extender controller for interface between a human operator and a physical object through a physical plant. The human extender controller uses an inner-feedback loop to increase the equivalent damping of the operating system to stabilize the system when it contacts with the environment and reduces the impact of the environment variation by utilizing a high feedback gain, determined by a root locus sketch. Because the stability of the human extender controller of the present invention is greatly enhanced over that of the prior art, the present invention is able to achieve a force reflection ratio 500 to 1 and capable of handling loads above the two (2) ton range.

Jansen, John F. (Knoxville, TN)

2001-01-01T23:59:59.000Z

256

New human resources division leader selected  

NLE Websites -- All DOE Office Websites (Extended Search)

Oak Ridge, Tennessee, and most recently, as the Human Resources Division Manager at the Pantex Plant in Amarillo, Texas. Hampton has been successful in implementing policies and...

257

The complete sequence of human chromosome 5  

E-Print Network (OSTI)

International Human Genome Sequencing Consortium. Initialof problem solving in genome sequencing. Genome Res. 8, 562-8 (2001). 23. Mouse Genome Sequencing Consortium. Initial

2004-01-01T23:59:59.000Z

258

Office of Human Resource Services (HC-30)  

Energy.gov (U.S. Department of Energy (DOE))

This organization provides a full range of human capital management (HCM) operational functions, employee work life programs, workforce service delivery, and day-to-day operational support for...

259

Human Capital Management Accountability Program (HCMAP)  

Energy.gov (U.S. Department of Energy (DOE))

Human Capital Management Accountability Program (HCMAP) is an online program which serves as the vehicle for identifying and measuring these three factors, effectiveness, efficiency, and timeliness...

260

Employee and Guest Records, Human Resources  

NLE Websites -- All DOE Office Websites (Extended Search)

& Guest Records Verification of Employment (see below) Guest Information System (GIS) Request for Access to Human Resources Systems (pdf) Staff Information Verification of...

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Human Resources & EEO/Diversity Symposium  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Resources & EEODiversity Symposium Table of Contents Disclaimer Presentations Track I - The HR Environment Track II - The HR Response Track III - Training & Career Track IV...

262

Quality of Life After Palliative Radiation Therapy for Patients With Painful Bone Metastases: Results of an International Study Validating the EORTC QLQ-BM22  

SciTech Connect

Purpose: Radiation therapy (RT) is an effective method of palliating painful bone metastases and can improve function and reduce analgesic requirements. In advanced cancer patients, quality of life (QOL) is the primary outcome of interest over traditional endpoints such as survival. The purpose of our study was to compare bone metastasis-specific QOL scores among patients who responded differently to palliative RT. Methods and Materials: Patients receiving RT for bone metastases across 6 countries were prospectively enrolled from March 2010-January 2011 in a trial validating the QLQ-BM22 and completed the QLQ-BM22 and the core measure (QLQ-C30) at baseline and after 1 month. Pain scores and analgesic intake were recorded, and response to RT was determined according to the latest published guidelines. The Kruskal-Wallis nonparametric and Wilcoxon rank sum tests compared changes in QOL among response groups. A Bonferroni-adjusted P<.003 indicated statistical significance. Results: Of 79 patients who received palliative RT, 59 were assessable. Partial response, pain progression, and indeterminate response were observed in 22, 8, and 29 patients, respectively; there were no patients with a complete response. Patients across all groups had similar baseline QOL scores apart from physical functioning (patients who progressed had better initial functioning). One month after RT, patients who responded had significant improvements in 3 of 4 QLQ-BM22 domains (painful site, P<.0001; painful characteristic, P<.0001; and functional interference, P<.0001) and 3 QLQ-C30 domains (physical functioning, P=.0006; role functioning, P=.0026; and pain, P<.0001). Patients with progression in pain had significantly worse functional interference (P=.0007) and pain (P=.0019). Conclusions: Patients who report pain relief after palliative RT also have better QOL with respect to bone metastasis-specific issues. The QLQ-BM22 and QLQ-C30 are able to discriminate among patients with varying responses and are recommended for use in future bone metastasis clinical trials.

Zeng Liang [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada)] [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada); Chow, Edward, E-mail: edward.chow@sunnybrook.ca [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada)] [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada); Bedard, Gillian; Zhang, Liying [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada)] [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, Ontario (Canada); Fairchild, Alysa [Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada)] [Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alberta (Canada); Vassiliou, Vassilios [Department of Radiation Oncology, Bank of Cyprus Oncology Centre, Nicosia (Cyprus)] [Department of Radiation Oncology, Bank of Cyprus Oncology Centre, Nicosia (Cyprus); Alm El-Din, Mohamed A. [Department of Clinical Oncology, Tanta University Hospital, Tanta Faculty of Medicine, Tanta (Egypt)] [Department of Clinical Oncology, Tanta University Hospital, Tanta Faculty of Medicine, Tanta (Egypt); Jesus-Garcia, Reynaldo [Department of Orthopedic Oncology, Federal University of Sao Paulo, Sao Paulo (Brazil)] [Department of Orthopedic Oncology, Federal University of Sao Paulo, Sao Paulo (Brazil); Kumar, Aswin [Division of Gynaecology and Genitourinary Oncology, Department of Radiation Oncology, Regional Cancer Center, Trivandrum (India)] [Division of Gynaecology and Genitourinary Oncology, Department of Radiation Oncology, Regional Cancer Center, Trivandrum (India); Forges, Fabien [Inserm CIE3, Saint Etienne University Hospital, Saint-Etienne (France) [Inserm CIE3, Saint Etienne University Hospital, Saint-Etienne (France); Unit of Clinical Research, Innovation, and Pharmacology, Saint Etienne University Hospital, Saint-Etienne (France); Tseng, Ling-Ming [Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan (China)] [Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan (China); Hou, Ming-Feng [Department of Gastroenterologic Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan (China)] [Department of Gastroenterologic Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan (China); Chie, Wei-Chu [Department of Public Health and Institute of Epidemiology and Preventative Medicine, National Taiwan University, Taipei, Taiwan (China)] [Department of Public Health and Institute of Epidemiology and Preventative Medicine, National Taiwan University, Taipei, Taiwan (China); Bottomley, Andrew [European Organisation for Research and Treatment of Cancer, EORTC Headquarters, Brussels (Belgium)] [European Organisation for Research and Treatment of Cancer, EORTC Headquarters, Brussels (Belgium)

2012-11-01T23:59:59.000Z

263

Emotion induction during human-robot interaction  

Science Conference Proceedings (OSTI)

The aim of the presented study was to measure physiological correlates of emotions that are of particular interest in the field of human-robot interaction (HRI). Therefore, we did not focus on self-induced basic emotions but rather evoked states that ... Keywords: emotion recognition, human-robot interaction, joint construction, stress induction

Cornelia Wendt; Michael Popp; Berthold Faerber

2009-03-01T23:59:59.000Z

264

Culture Representation in Human Reliability Analysis  

Science Conference Proceedings (OSTI)

Understanding human-system response is critical to being able to plan and predict mission success in the modern battlespace. Commonly, human reliability analysis has been used to predict failures of human performance in complex, critical systems. However, most human reliability methods fail to take culture into account. This paper takes an easily understood state of the art human reliability analysis method and extends that method to account for the influence of culture, including acceptance of new technology, upon performance. The cultural parameters used to modify the human reliability analysis were determined from two standard industry approaches to cultural assessment: Hofstede’s (1991) cultural factors and Davis’ (1989) technology acceptance model (TAM). The result is called the Culture Adjustment Method (CAM). An example is presented that (1) reviews human reliability assessment with and without cultural attributes for a Supervisory Control and Data Acquisition (SCADA) system attack, (2) demonstrates how country specific information can be used to increase the realism of HRA modeling, and (3) discusses the differences in human error probability estimates arising from cultural differences.

David Gertman; Julie Marble; Steven Novack

2006-12-01T23:59:59.000Z

265

Human-aware computer system design  

Science Conference Proceedings (OSTI)

In this paper, we argue that human-factors studies are critical in building a wide range of dependable systems. In particular, only with a deep understanding of the causes, types, and likelihoods of human mistakes can we build systems that prevent, hide, ...

Ricardo Bianchini; Richard P. Martin; Kiran Nagaraja; Thu D. Nguyen; Fábio Oliveira

2005-06-01T23:59:59.000Z

266

Hierarchical pose estimation for human gait analysis  

Science Conference Proceedings (OSTI)

Articulated structures like the human body have many degrees of freedom. This makes an evaluation of the configuration's likelihood very challenging. In this work we propose new linked hierarchical graphical models which are able to efficiently evaluate ... Keywords: Gait analysis, Hierarchical graphical model, Human pose estimation, Markov random fields

Jens Spehr; Simon Winkelbach; Friedrich M. Wahl

2012-05-01T23:59:59.000Z

267

Real-time individualized virtual humans  

Science Conference Proceedings (OSTI)

This tutorial will present the latest techniques to model fast individualized animatable virtual humans for Real-Time applications. As a human is composed of a head and a body, we will analyze how these two parts can be modeled and globally animated ...

Nadia Magnenat-Thalmann; Daniel Thalmann

2008-12-01T23:59:59.000Z

268

Human Resource Management on Social Capital  

Science Conference Proceedings (OSTI)

Over the past years, several researchers have analysed the relational dynamics that takes place inside and between organizations concept, mediating and moderating variables, effects, etc. considering it as a resource capable of contributing to the orientation ... Keywords: Human Resource Policy, Human Resources Management, Information Technology, Proposed a Model, Social Capital

Macarena López-Fernández; Fernando Martín-Alcázar; Pedro Miguel Romero-Fernández

2010-04-01T23:59:59.000Z

269

Human mobility modeling at metropolitan scales  

Science Conference Proceedings (OSTI)

Models of human mobility have broad applicability in fields such as mobile computing, urban planning, and ecology. This paper proposes and evaluates WHERE, a novel approach to modeling how large populations move within different metropolitan areas. ... Keywords: call detail records, human mobility patterns

Sibren Isaacman; Richard Becker; Ramón Cáceres; Margaret Martonosi; James Rowland; Alexander Varshavsky; Walter Willinger

2012-06-01T23:59:59.000Z

270

Diversity at Fermilab - Human Rights Policy  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Rights Policy Human Rights Policy Fermilab attracts scientists, not only from this country, but from many other nations all over the world. Foreign visitors, laypersons, as well as scientists, come to the laboratory to participate in its work. They represent a wide variety of races, nationalities, cultures and beliefs. It is essential that we provide an environment and maintain an atmosphere in which both staff and visitors can live and work with pride and dignity without regard to such differences as race, religion, sex, or national origin. In any conflict between technical expediency and human rights we will stand on the side of human rights. This is because of our dedication to science. The support of human rights in our laboratory and its environs is inextricably intertwined with our goal of making the Laboratory a center of technical and scientific excellence. The latter is not likely to be achieved without success of the former.

271

ORISE: Human Subjects Protection Resource Protection Book  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Subjects Protection Resource Book Human Subjects Protection Resource Book The Human Subjects Protection Resource Book synthesizes information currently available on the protection of human subjects in research, the continuing application of such information to new areas of endeavor, and ever-changing rules, regulations, and guidance. This resource, to which the Oak Ridge Institute for Science and Education (ORISE) contributed, is for investigators, institutional review boards, research organizations, research subjects and others. The book contains chapters that provide background information on the history and development of federal regulations; chapters that discuss procedural and substantive issues regarding the review and conduct of human subjects research; and chapters that are specific to one type of research

272

History of the DOE Human Genome Program  

Office of Scientific and Technical Information (OSTI)

History of the DOE Human Genome Program History of the DOE Human Genome Program The following history is taken from the U.S. Department of Energy 1991-91 Human Genome Program Report (June 1992). This is an archived item. A brief history of the U.S. Department of Energy (DOE) Human Genome Program will be useful in a discussion of the objectives of the DOE program as well as those of the collaborative U.S. Human Genome Project. The Office of Health and Environmental Research (OHER) of DOE and its predecessor agencies--the Atomic Energy Commission and the Energy Research and Development Administration--have long sponsored research into genetics, both in microbial systems and in mammals, including basic studies on genome structure, replication, damage, and repair and the consequences of genetic

273

Habitat for Humanity | Open Energy Information  

Open Energy Info (EERE)

Habitat for Humanity Habitat for Humanity Jump to: navigation, search Name Habitat for Humanity Place Americus, GA Website http://www.habitat.org/ References NREL Technical Report: Zero Energy Home[1] Fact Sheet: Zero Energy Demonstration Home[2] Information About Partnership with NREL Partnership with NREL Yes Partnership Type Test & Evaluation Partner Partnering Center within NREL Electricity Resources & Building Systems Integration Partnership Year 2005 LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! Habitat for Humanity is a company located in Americus, GA. References ↑ "NREL Technical Report: Zero Energy Home" ↑ "Fact Sheet: Zero Energy Demonstration Home" Retrieved from "http://en.openei.org/w/index.php?title=Habitat_for_Humanity&oldid=38172

274

A mathematical model for predicting the probability of acute mortality in a human population exposed to accidentally released airborne radionuclides. Final report for Phase I of the project: early effects of inhaled radionuclides  

Science Conference Proceedings (OSTI)

The report presents a mathematical model for the purpose of predicting the fraction of human population which would die within 1 year of an accidental exposure to airborne radionuclides. The model is based on data from laboratory experiments with rats, dogs and baboons, and from human epidemiological data. Doses from external, whole-body irradiation and from inhaled, alpha- and beta-emitting radionuclides are calculated for several organs. The probabilities of death from radiation pneumonitis and from bone marrow irradiation are predicted from doses accumulated within 30 days of exposure to the radioactive aerosol. The model is compared with existing similar models under hypothetical exposure conditions. Suggestions for further experiments with inhaled radionuclides are included.

Filipy, R.E.; Borst, F.J.; Cross, F.T.; Park, J.F.; Moss, O.R.

1980-06-01T23:59:59.000Z

275

The potential human health effect(s) of the metal uranium in the environment. Report on the known human health effects associated with the exposure to the metal uranium  

SciTech Connect

Concern over the levels of the metal uranium in the environment as a result of industrial activities has been expressed by several Federal and State agencies. This concern is associated with potential human health effects of this metal on kidney function and bone formation. Although limits for the Metal uranium in the environment remain to be set, the Environmental Protection Agency (EPA) is currently in the process of establishing guidance limits for this metal in water and soil. These limits will be established for both the metal and the associated radioactivity. The suggested limits currently being considered for water and soil are, 20 pCi/liter and 10 pCi/gram wet weight, respectively. For naturally occurring uranium EPA assumes that 1 ug of uranium metal equals 0.67 pCi at equilibrium (i.e. at equilibrium the mass ratio of {sup 234}uranium to {sup 238}uranium is small but their activities are equal). Thus the limits for water and soil on weight basis for the uranium metal would be 30 ug/liter and 15 ug/gram wet weight, respectively. These limits are being established based on the potential increase in cancer death in populations that exceed this limit. Since there does not appear to be a significant correlation between cancer deaths and.uranium metal exposure (see discussion below), these limits will probably be established based on the known association between radionuclides exposure and cancer deaths. The exposure limits for other health effects such as kidney damage and retardation in bone formation apparently are not being considered by EPA.

1990-12-31T23:59:59.000Z

276

Atomic magnetometer for human magnetoencephalograpy.  

SciTech Connect

We have developed a high sensitivity (<5 fTesla/{radical}Hz), fiber-optically coupled magnetometer to detect magnetic fields produced by the human brain. This is the first demonstration of a noncryogenic sensor that could replace cryogenic superconducting quantum interference device (SQUID) magnetometers in magnetoencephalography (MEG) and is an important advance in realizing cost-effective MEG. Within the sensor, a rubidium vapor is optically pumped with 795 laser light while field-induced optical rotations are measured with 780 nm laser light. Both beams share a single optical axis to maximize simplicity and compactness. In collaboration with neuroscientists at The Mind Research Network in Albuquerque, NM, the evoked responses resulting from median nerve and auditory stimulation were recorded with the atomic magnetometer and a commercial SQUID-based MEG system with signals comparing favorably. Multi-sensor operation has been demonstrated with two AMs placed on opposite sides of the head. Straightforward miniaturization would enable high-density sensor arrays for whole-head magnetoencephalography.

Schwindt, Peter; Johnson, Cort N.

2010-12-01T23:59:59.000Z

277

Deformable human body model development  

SciTech Connect

This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). A Deformable Human Body Model (DHBM) capable of simulating a wide variety of deformation interactions between man and his environment has been developed. The model was intended to have applications in automobile safety analysis, soldier survivability studies and assistive technology development for the disabled. To date, we have demonstrated the utility of the DHBM in automobile safety analysis and are currently engaged in discussions with the U.S. military involving two additional applications. More specifically, the DHBM has been incorporated into a Virtual Safety Lab (VSL) for automobile design under contract to General Motors Corporation. Furthermore, we have won $1.8M in funding from the U.S. Army Medical Research and Material Command for development of a noninvasive intracranial pressure measurement system. The proposed research makes use of the detailed head model that is a component of the DHBM; the project duration is three years. In addition, we have been contacted by the Air Force Armstrong Aerospace Medical Research Laboratory concerning possible use of the DHBM in analyzing the loads and injury potential to pilots upon ejection from military aircraft. Current discussions with Armstrong involve possible LANL participation in a comparison between DHBM and the Air Force Articulated Total Body (ATB) model that is the current military standard.

Wray, W.O.; Aida, T.

1998-11-01T23:59:59.000Z

278

(Multiplex mapping of human cDNAs)  

SciTech Connect

We have tested and implemented several protocols to increase productivity for mapping expressed sequence tags EST sequences to human chromosomes. These protocols include adopting PRIMER which permits utilization of batch files, as the standard software for PCR primer design; adding a human 21-only cell line to the NIGMS panel No. 1 to improve discrimination in discordancy analyses involving chromosome 21, adding a monochromosomal hybrid panel to facilitate chromosome assignment of sequences that are amplified from more than 1 chromosome; combining the products of multiple PCR reactions for electrophoretic analysis (pseudoplexing); routinely multiplexing PCR reactions; and automating data entry and analysis as much as possible. We have applied these protocols to assign an overall total of 132 human brain CDNA sequences to individual human chromosomes. PCR primers were designed from ESTS and tested for specific amplification from human genomic DNA. DNA was then amplified using DNA from somatic cell hybrid mapping panels as templates. The amplification products were identified using an automated fluorescence detection system. Chromosomal assignments were made by discordancy analysis. The localized cDNAs include 2 for known human genes, 2 that map to 2 different human chromosomes, and 25 for cDNAs matching existing database records.

Nierman, W.C.

1992-01-01T23:59:59.000Z

279

Human Reliability Considerations for Small Modular Reactors  

DOE Green Energy (OSTI)

Small modular reactors (SMRs) are a promising approach to meeting future energy needs. Although the electrical output of an individual SMR is relatively small compared to that of typical commercial nuclear plants, they can be grouped to produce as much energy as a utility demands. Furthermore, SMRs can be used for other purposes, such as producing hydrogen and generating process heat. The design characteristics of many SMRs differ from those of current conventional plants and may require a distinct concept of operations. The U.S. Nuclear Regulatory Commission (NRC) conducted research to examine the human factors engineering and the operational aspects of SMRs. The research identified thirty potential human-performance issues that should be considered in the NRC's reviews of SMR designs and in future research activities. The purpose of this report is to illustrate how the issues can support SMR probabilistic risk analyses and their review by identifying potential human failure events for a subset of the issues. As part of addressing the human contribution to plant risk, human reliability analysis practitioners identify and quantify the human failure events that can negatively impact normal or emergency plant operations. The results illustrated here can be generalized to identify additional human failure events for the issues discussed and can be applied to those issues not discussed in this report.

OHara J. M.; Higgins, H.; DAgostino, A.; Erasmia, L.

2012-01-27T23:59:59.000Z

280

Including the Human Factor in Dependability Benchmarks  

E-Print Network (OSTI)

We describe the construction of a dependability benchmark that captures the impact of the human system operator on the tested system. Our benchmark follows the usual model of injecting faults and perturbations into the tested system; however, our perturbations are generated by the unscripted actions of actual human operators participating in the benchmark procedure in addition to more traditional fault injection. We introduce the issues that arise as we attempt to incorporate human behavior into a dependability benchmark and describe the possible solutions that we have arrived at through preliminary experimentation. Finally, we describe the implementation of our techniques in a dependability benchmark that we are currently developing

Aaron B. Brown; Leonard C. Chung; David A. Patterson

2002-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Human retroviruses and AIDS 1997  

Science Conference Proceedings (OSTI)

This compendium is the result of an effort to compile, organize, and rapidly publish as much relevant molecular data concerning the human immunodeficiency viruses (HIV) and related retroviruses as possible. The scope of the compendium and database is best summarized by the four parts that it comprises: (1) Nucleic Acid Alignments, (2) Amino Acid Alignments, (3) Reviews and Analyses, and (4) Related Sequences. Information within all the parts is updated throughout the year on the Web site, http://hiv-web.lanl.gov. This year we are not including floppy diskettes as the entire compendium is available both at our Web site and at our ftp site. If you need floppy diskettes please contact either Bette Korber (btk@t10.lanl.gov) or Kersti Rock (karm@t10.lanl.gov) by email or fax ((505) 665-4453). While this publication could take the form of a review or sequence monograph, it is not so conceived. Instead, the literature from which the database is derived has simply been summarized and some elementary computational analyses have been performed upon the data. Interpretation and commentary have been avoided insofar as possible so that the reader can form his or her own judgments concerning the complex information. The exception to this are reviews submitted by experts in areas deemed of particular and basic importance to research involving AIDS viral sequence information. These are included in Part III, and are contributed by scientists with particular expertise in the area of interest. In addition to the general descriptions below of the parts of the compendium, the user should read the individual introductions for each part.

Korber, B.; Foley, B.; Leitner, T. [eds.] [and others] [eds.; and others

1997-12-01T23:59:59.000Z

282

The relationship between the bone mineral density and urinary cadmium concentration of residents in an industrial complex  

SciTech Connect

Background: An association between cadmium exposure and bone mineral density (BMD) has been demonstrated in elderly women, but has not been well studied in youths and men. Some studies report either no or a weak association between cadmium exposure and bone damage. Objectives: This study was designed to investigate the relationship between the urinary cadmium (U-Cd) levels and BMD of females and males of all ages. Methods: A total of 804 residents near an industrial complex were surveyed in 2007. U-Cd and BMD on the heel (non-dominant calcaneus) were analyzed with AAS-GTA and Dual-Energy X-ray absorptiometry, respectively. Demographic characteristics were collected by structured questionnaires. Osteoporosis and osteopenia were defined by BMD cut-off values and T-scores set by the WHO; T score>-1, normal; -2.5=}1.0 {mu}g/g creatinine) in females (OR=2.92; 95% CI, 1.51-5.64) and in males (OR=3.37; 95% CI, 1.09-10.38). With the multiple linear regression model, the BMD of the adult group was negatively associated with U-Cd (<0.05), gender (female, p<0.001) and age (p<0.001). The BMD of participants who were {<=}19 years of age was negatively associated with gender (female, p<0.01), whereas it was positively associated with age and BMI (p<0.001). BMD was not associated with exercise, smoking habits, alcohol consumption, job or parental education. Conclusion: Results suggested that U-Cd might be associated with osteopenia as well as osteoporosis in both male and female adults. Age and female gender were negatively associated with BMD in the adult group, whereas age was positively associated with BMD in the youth group. Cadmium exposure may be a potential risk factor for lower-BMD and osteopenia symptoms as well as for osteoporosis symptoms. - Research Highlights: {yields} The relationship between the urinary cadmium levels and BMD was investigated. {yields} U-Cd was associated with osteopenia and osteoporosis in adults. {yields} Cadmium exposure may be a potential risk factor for lower-BMD and osteopenia.

Shin, Minah; Paek, Domyung [Institute of Health and Environment, Department of Environmental Health, School of Public Health, Seoul National University, Gwanak-599, Gwanak-gu, Seoul 151-742 (Korea, Republic of)] [Institute of Health and Environment, Department of Environmental Health, School of Public Health, Seoul National University, Gwanak-599, Gwanak-gu, Seoul 151-742 (Korea, Republic of); Yoon, Chungsik, E-mail: csyoon@snu.ac.kr [Institute of Health and Environment, Department of Environmental Health, School of Public Health, Seoul National University, Gwanak-599, Gwanak-gu, Seoul 151-742 (Korea, Republic of)] [Institute of Health and Environment, Department of Environmental Health, School of Public Health, Seoul National University, Gwanak-599, Gwanak-gu, Seoul 151-742 (Korea, Republic of)

2011-01-15T23:59:59.000Z

283

Improving The Representation Of Human Error In The Use Of The Flight Crew Human Factors Integration Tool  

E-Print Network (OSTI)

1-15. Norman, D.A. (1983). Position paper on human error.Research Workshop on Human Error . Bellagio, Italy. O'Hare,M. (1996). Breakdown of human error models , Prepared for

Gosling, Geoffrey; Roberts, Karlene H.; Jayaswal, Arpana

1998-01-01T23:59:59.000Z

284

Human-robot cross-training: Computational formulation, modeling and evaluation of a human team training strategy  

E-Print Network (OSTI)

We design and evaluate human-robot cross-training, a strategy widely used and validated for effective human team training. Cross-training is an interactive planning method in which a human and a robot iteratively switch ...

Nikolaidis, Stefanos

285

Automated-Manual Transitions: Human Capabilities and Adaptive Cruise Control  

E-Print Network (OSTI)

TRANSIT AND HIGHWAYS Automated-Manual Transitions: HumanOF CALIFORNIA, BERKELEY Automated-Manual Transitions: HumanSuch systems will supplant manual controls during certain

Barton, Joseph E.; Cohn, Theodore E.; Nguyen, Khoi M.; Nguyen, Tieuvi; Toyofuku, Natsuko

2004-01-01T23:59:59.000Z

286

Training Program EHS 740 ~ Human Subjects Research Training Program  

NLE Websites -- All DOE Office Websites (Extended Search)

740 Human Subjects Research Training Program Course Syllabus Subject Category: Human Subjects Research Course Prerequisite: None Course Length: 1 hour Medical Approval: None...

287

Lawrence Livermore study finds human activity affects vertical...  

NLE Websites -- All DOE Office Websites (Extended Search)

human activity affects vertical structure of atmospheric temperature Anne M Stark, LLNL, (925) 422-9799, stark8@llnl.gov Human influences have directly impacted the latitude...

288

Human Engineering Design Guidelines for Maintainability  

Science Conference Proceedings (OSTI)

Utility managers, designers, and engineers can now systematically incorporate appropriate human factors engineering principles and criteria for maintainability into new plant designs or existing plant modifications. Using these guidelines can also result in increased productivity, safety, and plant availability.

1985-12-01T23:59:59.000Z

289

HST.071 Human Reproductive Biology, Fall 2002  

E-Print Network (OSTI)

Lectures and clinical case discussions designed to provide the student with a clear understanding of the physiology, endocrinology, and pathology of human reproduction. Emphasis is on the role of technology in reproductive ...

Klapholz, Henry

290

Human Subjects Research, Office of Research Administration  

NLE Websites -- All DOE Office Websites (Extended Search)

search BNL Go Site Details Homepage Human Subjects Research Animal Research Contact Us Other Information BNL Visitor Information Directions to BNL BNL Site Index Can't View PDFs?...

291

Scientists Help Define the Healthy Human Microbiome  

NLE Websites -- All DOE Office Websites (Extended Search)

years of research. Berkeley Lab's role in mapping the human microbiome revolves around big data, both analyzing it and making it available for scientists to use worldwide. 3.5...

292

Video looping of human cyclic motion  

E-Print Network (OSTI)

In this thesis, a system called Video Looping is developed to analyze human cyclic motions. Video Looping allows users to extract human cyclic motion from a given video sequence. This system analyzes similarities from a large amount of live footage to find the point of smooth transition. The final cyclic loop is created using only a few output images. Video Looping is useful not only to learn and understand human movements, but also to apply the cyclic loop to various artistic applications. To provide practical animation references, the output images are presented as photo plate sequences to visualize human cyclic motion similar to Eadweard Muybridge's image sequences. The final output images can be used to create experimental projects such as composited multiple video loops or small size of web animations. Furthermore, they can be imported into animation packages, and animators can create keyframe animations by tracing them in 3D software.

Choi, Hye Mee

2006-05-01T23:59:59.000Z

293

Determination of plutonium in human urine  

SciTech Connect

Report is made of chemical procedures for determination of plutonium in human urine. The procedures are provided in outline form and statistical methods are provided for interpretation of the results.

Langham, W.H.

1947-08-14T23:59:59.000Z

294

2011-2015 Human Capital Management Plan  

Energy.gov (U.S. Department of Energy (DOE))

The Office of Legacy Management (LM) needs skilled and engaged staff to accomplish our mission and carry out our responsibilities to the American people. This Human Capital Management Plan (HCMP or...

295

Proxy genotypes and phenotypes for human genetics  

E-Print Network (OSTI)

Genetic mapping by association is an unbiased approach to discover genes and pathways influencing disease traits and response to drugs and environmental exposures. There are two key obstacles to mapping in humans: (1) The ...

Yelensky, Roman

2008-01-01T23:59:59.000Z

296

Multimodal human computer interaction: a survey  

Science Conference Proceedings (OSTI)

In this paper we review the major approaches to multimodal human computer interaction from a computer vision perspective. In particular, we focus on body, gesture, gaze, and affective interaction (facial expression recognition, and emotion in audio). ...

Alejandro Jaimes; Nicu Sebe

2005-10-01T23:59:59.000Z

297

Embodied cognition in robots and human evolution  

E-Print Network (OSTI)

This thesis investigates the notion of embodied cognition in humans using the research of former University of Washington researcher William Calvin and robots using the research of former MIT professor Rodney Brooks. The ...

Myhrvold, Conor L. (Conor Lachlan)

2012-01-01T23:59:59.000Z

298

Meeting Human Reliability Requirements through Human Factors Design, Testing, and Modeling  

SciTech Connect

In the design of novel systems, it is important for the human factors engineer to work in parallel with the human reliability analyst to arrive at the safest achievable design that meets design team safety goals and certification or regulatory requirements. This paper introduces the System Development Safety Triptych, a checklist of considerations for the interplay of human factors and human reliability through design, testing, and modeling in product development. This paper also explores three phases of safe system development, corresponding to the conception, design, and implementation of a system.

R. L. Boring

2007-06-01T23:59:59.000Z

299

Human support improvements by natural man-machine collaboration  

Science Conference Proceedings (OSTI)

In this paper, we propose a novel framework that improves the recognition performance of human support systems, and then discuss why our framework is Human-Centered. A Human-Centered system should have a high recognition ability with minimum burden on ... Keywords: human-centered computing, interactive system

Motoyuki Ozeki; Yasushi Miyata; Hideki Aoyama; Yuichi Nakamura

2007-09-01T23:59:59.000Z

300

National Aeronautics and Space Administration Human Research Program (HRP)  

E-Print Network (OSTI)

: Organization HQ Human Exploration and Operations Mission Directorate (AA) Directorate Program Management

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

A New Method to Evaluate Human-Robot System Performance  

Science Conference Proceedings (OSTI)

One of the key issues in space exploration is that of deciding what space tasks are best done with humans, with robots, or a suitable combination of each. In general, human and robot skills are complementary. Humans provide as yet unmatched capabilities ... Keywords: analysis, human-robot systems, performance, robotics

G. Rodriguez; C. R. Weisbin

2003-03-01T23:59:59.000Z

302

Human Rights and Rule of Law: What's The Relationship  

E-Print Network (OSTI)

ways that are considered arbitrary detention or torture under international human rights standards (

Peerenboom, Randall P

2005-01-01T23:59:59.000Z

303

Contaminants, Water and Human Health: New Lessons from ...  

Science Conference Proceedings (OSTI)

Contaminants, Water and Human Health: New Lessons from Alligators. Purpose: Many chemicals introduced into the environment ...

2012-06-01T23:59:59.000Z

304

Perception modeling for human-like artificial sensor systems  

Science Conference Proceedings (OSTI)

In this article we present an approach to the design of human-like artificial systems. It uses a perception model to describe how sensory information is processed for a particular task and to correlate human and artificial perception. Since human-like ... Keywords: Active perception, Artificial hand, Artificial perceptual systems, Dexterous manipulation, Electronic tongue, Human-based sensors, Passive perception

Linn Robertsson; Boyko Iliev; Rainer Palm; Peter Wide

2007-05-01T23:59:59.000Z

305

Control architecture for human friendly robots based on interacting with human  

Science Conference Proceedings (OSTI)

This paper discusses a control architecture for human friendly robot. Recently, robot middleware is developed for intelligent robot software platform. The robot system can be constructed by making the program of each functional module and connecting ... Keywords: 3D-range camera, human friendly robot, software architecture

Hiroyuki Masuta; Eriko Hiwada; Naoyuki Kubota

2011-12-01T23:59:59.000Z

306

Carbon stored in human settlements: the conterminous  

E-Print Network (OSTI)

Urban areas are home to more than half of the world’s people, responsible for 470 % of anthropogenic release of carbon dioxide and 76 % of wood used for industrial purposes. By 2050 the proportion of the urban population is expected to increase to 70 % worldwide. Despite fast rates of change and potential value for mitigation of carbon dioxide emissions, the organic carbon storage in human settlements has not been well quantified. Here, we show that human settlements can store as much carbon per unit area (23–42 kg C m 2 urban areas and 7–16 kg C m 2 exurban areas) as tropical forests, which have the highest carbon density of natural ecosystems (4–25 kg C m 2). By the year 2000 carbon storage attributed to human settlements of the conterminous United States was 18 Pg of carbon or 10 % of its total land carbon storage. Sixty-four percent of this carbon was attributed to soil, 20 % to vegetation, 11 % to landfills, and 5 % to buildings. To offset rising urban emissions of carbon, regional and national governments should consider how to protect or even to increase carbon storage of human-dominated landscapes. Rigorous studies addressing carbon budgets of human settlements and vulnerability of their carbon storage are needed.

unknown authors

2009-01-01T23:59:59.000Z

307

PRIVACY IMPACT ASSESSMENT: Human Resources Personal Information  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Human Human Resources - Personal Information Change Request PIA Template Version 3 - May, 2009 Department of Energy Privacy Impact Assessment (PIA) Guidance is provided in the template. See DOE Order 206.1, Department of Energy Privacy Program, Appendix A, Privacy Impact Assessments, for requirements and additional guidance for conducting a PIA: http://www.directives.doe.gov/pdfs/doe/doetext/neword/206/o2061.pdf Please complete electronically: no hand-written submissions will be accepted. This template may not be modified. MODULE 1- PRIVACY NEEDS ASSESSMENT Date Departmental Element & Site Idaho National Engineering Laboratory Engineering Research Office Building (EROB) Name of Information Human Resources - Personal Information Change Request System or IT Project Business Enclave Exhibit Project UID 106800 NewPIA ~ Update D N T 'tl I Contact Information arne,

308

Dishwasher: 1; Human: 0 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Dishwasher: 1; Human: 0 Dishwasher: 1; Human: 0 Dishwasher: 1; Human: 0 December 21, 2009 - 10:58am Addthis Amy Foster Parish My dishwasher and I have been locked in mortal combat for almost a month now, ever since it decided to quit working at nearly the same moment I decided to start washing the Thanksgiving dinner dishes. Over the past week it has started to look as if the dishwasher may have won the battle. And so, while I've been contemplating washing all those Christmas dishes by hand this year, I've also been shopping for a new energy-efficient dishwasher to replace my old one. As someone who's planning on buying a new appliance in the near future, I've been really excited about the possibility of taking advantage of new state rebates for the purchase of ENERGY STAR® qualified appliances.

309

Human Resources Reports | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Human Resources Reports Human Resources Reports Human Resources Reports August 21, 2013 Inspection Report: INS-L-13-06 Allegations of Irregular Hiring Practices and Preferential Treatment in the Loan Programs Office July 16, 2013 MANAGEMENT ALERT: DOE/IG-0891 Allegations Regarding Prohibited Personnel Practices at the Bonneville Power Administration June 6, 2013 Inspection Report: DOE/IG-0888 Alleged Nepotism and Wasteful Spending in the Office of Energy Efficiency and Renewable Energy March 22, 2013 Inspection Report: DOE-IG-0882 Approval of Contractor Executive Salaries by Department of Energy Personnel June 22, 2012 Inspection Report: INS-L-12-04 Alleged Procurement and Hiring Practice Irregularities within the Office of Policy and International Affairs June 18, 2012 Audit Report: IG-0867

310

Link Climate Change and Human Health  

NLE Websites -- All DOE Office Websites (Extended Search)

Make Our Science Accessible Make Our Science Accessible Link Climate Change & Health Provide Data and Tools Coordinate Internationally Link Climate Change and Human Health Print E-mail Health News Check out the latest climate change and human health news and announcements in our Health News Feed. Climate change poses unique challenges to human health. Unlike health threats caused by a particular toxin or disease pathogen, there are many ways that climate change can lead to potentially harmful health effects. Direct health impacts may include increased illnesses and deaths from extreme heat events, injuries and deaths from extreme weather events, and respiratory illnesses due to changes in air quality Indirect health impacts include illnesses and deaths that may arise from

311

Report: Human Capital Discussion and Observations  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Human Capital Discussion, Human Capital Discussion, Observations, and Recommendations August 24, 2006 Submitted by: Mr. A. James Barnes and Mr. Dennis Ferrigno Background: During the March 23-24, 2006 EMAB Public Meeting, Assistant Secretary for Environmental Management (EM-1), James Rispoli, asked the EMAB members to pursue a review of EM Human Capital issues. Although the National Academy of Public Administration (NAPA) is also conducting a review of this topic - the results of which will be available in October 2007 - Mr. Rispoli instructed EMAB to identify areas that need improvement and make recommendations to begin bettering the program now. EMAB focused specifically on the areas of: Morale/Workplace Census Planning/Accountability Training/Certification

312

Rocky Mountain Humane Investing | Open Energy Information  

Open Energy Info (EERE)

Humane Investing Humane Investing Jump to: navigation, search Name Rocky Mountain Humane Investing Place Allenspark, Colorado Zip 80510 Product Allenspark-based investment management firm prioritising Socially Responsible Investing (SRI). Coordinates 40.19472°, -105.525719° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":40.19472,"lon":-105.525719,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

313

Nuclear Power - Control, Reliability and Human Factors  

E-Print Network (OSTI)

Advances in reactor designs, materials and human-machine interfaces guarantee safety and reliability of emerging reactor technologies, eliminating possibilities for high-consequence human errors as those which have occurred in the past. New instrumentation and control technologies based in digital systems, novel sensors and measurement approaches facilitate safety, reliability and economic competitiveness of nuclear power options. Autonomous operation scenarios are becoming increasingly popular to consider for small modular systems. This book belongs to a series of books on nuclear power published by InTech. It consists of four major sections and contains twenty-one chapters on topics from key subject areas pertinent to instrumentation and control, operation reliability, system aging and human-machine interfaces. The book targets a broad potential readership group - students, researchers and specialists in the field - who are interested in learning about nuclear power.

Tsvetkov, Pavel

2011-09-01T23:59:59.000Z

314

Ontology-enriched Visualization of Human Anatomy  

SciTech Connect

The project focuses on the problem of presenting a human anatomical 3D model associated with other types of human systemic information ranging from physiological to anatomical information while navigating the 3D model. We propose a solution that integrates a visual 3D interface and navigation features with the display of structured information contained in an ontology of anatomy where the structures of the human body are formally and semantically linked. The displayed and annotated anatomy serves as a visual entry point into a patient's anatomy, medical indicators and other information. The ontology of medical information provides labeling to the highlighted anatomical parts in the 3D display. Because of the logical organization and links between anatomical objects found in the ontology and associated 3D model, the analysis of a structure by a physician is greatly enhanced. Navigation within the 3D visualization and between this visualization and objects representing anatomical concepts within the model is also featured.

Pouchard, LC

2005-12-20T23:59:59.000Z

315

Planet-scale Human Mobility Measurement  

E-Print Network (OSTI)

Research into, and design and construction of mobile systems and algorithms requires access to large-scale mobility data. Unfortunately, the wireless and mobile research community lacks such data. For instance, the largest available human contact traces contain only 100 nodes with very sparse connectivity, limited by experimental logistics. In this paper we pose a challenge to the community: how can we collect mobility data from billions of human participants? We re-assert the importance of large-scale datasets in communication network design, and claim that this could impact fundamental studies in other academic disciplines. In effect, we argue that planet-scale mobility measurements can help to save the world. For example, through understanding large-scale human mobility, we can track and model and contain the spread of epidemics of various kinds.

Pan Hui; Richard Mortier; Tristan Henderson; Jon Crowcroft

2009-09-18T23:59:59.000Z

316

Human exposure to dioxin from combustion sources  

SciTech Connect

Because of their extreme toxicity, much concern and debate has arisen about the nature and extent of human exposure to dioxin. Since municipal solid waste (MSW) incinerators are known to emit polychorinated dibenzo-p-dioxins (PCDDs) and polycholorinated dibenzofurnas (PCDFs) many people who live near MSW incinerators fear that they will be exposed to high levels of dioxin and subsequently develop cancer. What is often overlooked in this debate, however, is the fact that the general population is continuously being exposed to trace amounts of dioxin as exemplified by the fact that virtually all human adipose tissue samples contain dioxin at levels of 3 parts per trillion (ppt) or greater. This paper provides a perspective on MSW incineration as a source of human exposure to dioxin by comparing this exposure source with exposure to background environmental contamination and evaluates some of the potential key sources of PCDD/PCDF input into the enviroment. 32 refs., 3 tabs.

Hattemer-Frey, H.A.; Travis, C.C.

1988-01-01T23:59:59.000Z

317

Annotated bibliography of human factors applications literature  

Science Conference Proceedings (OSTI)

This bibliography was prepared as part of the Human Factors Technology Project, FY 1984, sponsored by the Office of Nuclear Safety, US Department of Energy. The project was conducted by Lawrence Livermore National Laboratory, with Essex Corporation as a subcontractor. The material presented here is a revision and expansion of the bibliographic material developed in FY 1982 as part of a previous Human Factors Technology Project. The previous bibliography was published September 30, 1982, as Attachment 1 to the FY 1982 Project Status Report.

McCafferty, D.B.

1984-09-30T23:59:59.000Z

318

Human Capital, the Structure of Production, and Growth  

E-Print Network (OSTI)

Do high levels of human capital foster economic growth by facilitating technology adoption? If so, countries with more human capital should have adopted more rapidly the skilled-labor augmenting technologies becoming available since the 1970’s. High human capital levels should therefore have translated into fast growth in more compared to less human-capital-intensive industries in the 1980’s. Theories of international specialization point to human capital accumulation as another important determinant of growth in human-capital-intensive industries. Using data for a large sample of countries, we find significant positive effects of human capital levels and human capital accumulation on output and employment growth in human-capital-intensive industries.

Antonio Ciccone; Elias Papaioannou; Luc Laeven; Pablo Fleiss

2009-01-01T23:59:59.000Z

319

Human effects on the global atmosphere  

SciTech Connect

This review considers whether human activities can significantly change important functions of the global atmosphere by altering the amount or distribution of certain trace species. It deals with three specific topics: stratopheric ozone, the role of species other than carbon dioxide on the greenhouse effect, and certain recently recognized atmospheric consequences of a large scale nuclear war. 64 references, 10 figures, 2 tables.

Johnston, H.S.

1984-01-01T23:59:59.000Z

320

Medical Examination Office of Human Resources  

E-Print Network (OSTI)

Medical Examination 4.40 Office of Human Resources Applies to: Faculty, staff, graduate associates-292-2800 ohrc@hr.osu.edu hr.osu.edu/elr Policy clarification for medical center employees Medical Center Employee Relations 614-293-4988 Medical exam arrangements Employee Health Services 614-293-8146 #12;

Howat, Ian M.

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
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they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
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321

Medical Examination Office of Human Resources  

E-Print Network (OSTI)

Medical Examination 4.40 Office of Human Resources Applies to: Faculty, staff, graduate associates or graduate associate or prospective employee or graduate associate to undergo medical examination or utensils, or food-contact surfaces. Policy Details I. Current Employees A job-related medical examination

Howat, Ian M.

322

The Appearance of Human Skin: A Survey  

Science Conference Proceedings (OSTI)

Skin is the outer-most tissue of the human body. As a result, people are very aware of, and very sensitive to, the appearance of their skin. Consequently, skin appearance has been a subject of great interest in various fields of science and technology. ...

Takanori Igarashi; Ko Nishino; Shree K. Nayar

2007-01-01T23:59:59.000Z

323

Wireless sensor networks and human comfort index  

Science Conference Proceedings (OSTI)

Conventional wireless home automation networks (WHANs) incorporate embedded wireless sensors and actuators that monitors and control home living environment. WHAN's primary goal is to maintain user comfort and efficient home management. Conventional ... Keywords: Ambient intelligence, Fuzzy logic, Human comfort, Wireless sensor network

Mohd Izani Rawi, Adnan Al-Anbuky

2013-06-01T23:59:59.000Z

324

A phenomenology of human-electricity relations  

Science Conference Proceedings (OSTI)

This paper investigates the philosophical question of how we can experience energy with the aim of informing the design of future ways of experiencing energy by means of technology. Four human-technology relations formulated by philosopher of technology ... Keywords: design theory, energy, phenomenology, sustainability

James Pierce; Eric Paulos

2011-05-01T23:59:59.000Z

325

Human-computer interaction for hybrid carving  

Science Conference Proceedings (OSTI)

In this paper we explore human-computer interaction for carving, building upon our previous work with the FreeD digital sculpting device. We contribute a new tool design (FreeD V2), with a novel set of interaction techniques for the fabrication of static ... Keywords: carving, computer-aided design (cad), craft, digital fabrication, milling.

Amit Zoran, Roy Shilkrot, Joseph Paradiso

2013-10-01T23:59:59.000Z

326

Exploring human judgement of digital imagery  

Science Conference Proceedings (OSTI)

Statistical learning methods are commonly applied in content-based video and image retrieval. Such methods require a large number of examples which are usually obtained through a manual annotation process, that is human raters review images and assign ... Keywords: image annotation, inter-rater agreement, latent class analysis, semantic annotation

Timo Volkmer; James A. Thom; S. M. M. Tahaghoghi

2007-01-01T23:59:59.000Z

327

Imputing human descriptions in semantic biometrics  

Science Conference Proceedings (OSTI)

Human identification at a distance has received significant interest due to the ever increasing surveillance infrastructure. Biometrics such as face and gait offer a suitable physical attribute to uniquely identify people from a distance. When linking ... Keywords: SVD, biometrics, imputation, latent semantic analysis, semantic biometrics, surveillance

Daniel A. Reid; Mark S. Nixon

2010-10-01T23:59:59.000Z

328

Conservation of angular momentum during human locomotion  

E-Print Network (OSTI)

The Problem: Our goal is to describe stable human locomotion, including walking and running, using the concept of conservation of angular momentum about the center of mass (CM) of the body. Motivation: The mechanics of walking and running are extremely complicated, exemplified by the fact that no robots can perform robust human walking. By focusing on angular momentum, a fundamental physical concept, we hope to develop a relatively simple model of stable motion. The angular momentum of a system is conserved if no external torques act on the system. During the aerial phase of locomotion, angular momentum is obviously conserved, but the interaction of the feet with the ground introduces external torques on the body. Therefore, there is no a priori reason for angular momentum in the CM frame to be conserved. However, recent observations in our research indicate that angular momentum is conserved to a large extent. Previous Work: Surprisingly, very little research has been done with regard to angular momentum during human locomotion. In 1986 Raibert mentioned the idea that “a control system that keeps the angular momentum constant during stance could achieve higher efficiency and better performance [2], ” but this approach has not been explored thoroughly. Approach: Our approach was to analyze real human locomotion data gathered in the Gait Laboratory of Spaulding Rehabilitation Hospital. The Gait Laboratory has facilities to obtain position data from markers placed at various

Marko Popovic; Wendy Gu; Hugh Herr

2002-01-01T23:59:59.000Z

329

Guidelines for Trial Use of Leading Indicators of Human Performance: The Human Performance Assistance Package  

Science Conference Proceedings (OSTI)

This report documents ongoing research and the results of two projects, Leading Indicators of Human Performance and Corrective Action Selection System. These projects have created the following products available to EPRI-member utilities: this report and two software programs with user manuals, Proactive Assessment of Organizational and Workplace Factors (PAOWF) and Corrective Action Research and Evaluation (CARE). Together, these elements constitute the Human Performance Assistance Package (HPAP).

2000-09-26T23:59:59.000Z

330

Lighting and Human Performance II: Beyond Visibility Models Toward a Unified Human Factors Approach to Performance  

Science Conference Proceedings (OSTI)

To understand the relationship between lighting conditions and human performance, it is first necessary to identify the routes by which lighting conditions can affect human performance. There are three such routes: the visual system, the circadian photobiological system, and the perceptual system. This report updates and replaces an earlier work and explores the relationship between lighting conditions and the ability to carry out tasks in interiors.

2001-10-29T23:59:59.000Z

331

Human error modeling predictions: increasing occupational safety using human performance modeling tools  

E-Print Network (OSTI)

Abstract: The use of computer-aided job analysis tools has been increasing in the recent past as a result of decreases in computational costs, augmentations in the reality of the computer-aided job analysis tools, and usefulness of the output generated from these tools. One tool set known as integrated Human Performance Modeling (HPM) is a humanout-of-the-loop (HOOTL) computational methodology used to generate predictions of complex human-automation integration and system flow patterns. These tools provide computational representations of humans incorporating physical, cognitive, perceptual, and environmental characteristics. Increasingly complex automation leads to a new class of errors and error vulnerabilities. Hollnagel’s (1993) Contextual Control Model (CoCoM) will be used as the human error theory behind a HOOTL simulation using Air Man-machine Integration Design and Analysis System (Air MIDAS) to evaluate complex humanautomation integration considerations currently underway at NASA Ames Research Center. This paper will highlight the importance of the physical and cognitive link of a specific task and will outline attempts being made to understand the factors underlying human error, a critical consideration of human-complex system performance.

Edited B. Das; Brian F. Gore; Kevin M. Corker

2001-01-01T23:59:59.000Z

332

Office of Human Resources and Administration - Mission and Functions  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Resources and Administration Human Resources and Administration Home Sub Offices › Business Operations › Human Resources and Administration › Information Management Mission & Functions › Information Management › Human Resources and Adminstration › Business Operations HSS Logo Office of Human Resources and Administration Reports to the Office of Resource Management Mission and Functions Mission The Office of Human Resources and Administration provides a broad range of human resource and administrative management activities in support of the Office of Health, Safety and Security (HSS). Functions Integrates, synchronizes, and concentrates human resource management activities in support of HSS, Departmental leadership, and other customers. Assists HSS managers in recruiting and hiring qualified, talented and capable candidates. Advises and informs HSS managers on hiring requirements, capabilities, and limitations. Assists managers, candidates, and new employees through the employment process. Manages special hiring programs such as interns, disadvantaged and minorities.

333

Using Analogy to Acquire Commonsense Knowledge from Human Contributors  

E-Print Network (OSTI)

The goal of the work reported here is to capture the commonsense knowledge of non-expert human contributors. Achieving this goal will enable more intelligent human-computer interfaces and pave the way for computers to ...

Chklovski, Timothy

2003-02-12T23:59:59.000Z

334

Human walking model predicts joint mechanics, electromyography and mechanical economy  

E-Print Network (OSTI)

In this paper, we present an under-actuated model of human walking, comprising only a soleus muscle and flexion/extension monoarticular hip muscles. The remaining muscle groups of the human leg are modeled using quasi-passive, ...

Endo, Ken

335

Fact SHEET FOR ŤHuman and natural influences on the Changing...  

NLE Websites -- All DOE Office Websites (Extended Search)

12, 2013 FACT SHEET FOR "HUMAN AND NATURAL INFLUENCES ON THE CHANGING THERMAL STRUCTURE OF THE ATMOSPHERE" 1 Fact sheet for "Human and natural influences on the changing thermal...

336

Assessing the performance of human-automation collaborative planning systems  

E-Print Network (OSTI)

Planning and Resource Allocation (P/RA) Human Supervisory Control (HSC) systems utilize the capabilities of both human operators and automated planning algorithms to schedule tasks for complex systems. In these systems, ...

Ryan, Jason C. (Jason Christopher)

2011-01-01T23:59:59.000Z

337

Essays on human capital and financial economics by Jialan Wang.  

E-Print Network (OSTI)

This thesis consists of three essays examining issues related to human capital, careers, and financial economics. In the first chapter, I examine how the process of corporate bankruptcy varies by human capital intensity ...

Wang, Jialan, Ph.D. Massachusetts Institute of Technology

2010-01-01T23:59:59.000Z

338

Human error contribution to nuclear materials-handling events  

E-Print Network (OSTI)

This thesis analyzes a sample of 15 fuel-handling events from the past ten years at commercial nuclear reactors with significant human error contributions in order to detail the contribution of human error to fuel-handling ...

Sutton, Bradley (Bradley Jordan)

2007-01-01T23:59:59.000Z

339

Human-automation interaction for lunar landing aimpoint redesignation  

E-Print Network (OSTI)

Human-automation interactions are a critical area of research in systems with modem automation. The decision-making portion of tasks presents a special challenge for human-automation interactions because of the many factors ...

Needham, Jennifer M

2008-01-01T23:59:59.000Z

340

Trust-based design of human-guided algorithms  

E-Print Network (OSTI)

By combining the strengths of human and computers, Human Machine Collaborative Decision Making has been shown to generate higher quality solutions in less time than conventional computerized methods. In many cases, it is ...

Thomer, Joseph L. (Joseph Louis)

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Digitisation and 3D Reconstruction of 30 Year Old Microscopic Sections of Human Embryo, Foetus  

E-Print Network (OSTI)

of our approach, we show a multi-planar reconstruction and a 3-D direct volume rendering, or thin partitions, found within the orbital fat. De Haan studied the development of the bones

342

Quantitative correlations among human mesenchymal stem cell mechanical properties and biological function  

E-Print Network (OSTI)

Mesenchymal stem cells (MSCs) are derived from bone marrow, and are capable of proliferating and differentiating along multiple pathways such as osteoblasts, chondrocytes and adipocytes. MSCs offer the means for regenerative ...

Jolibois-Quinot, Remi

2013-01-01T23:59:59.000Z

343

Human Fetal Liver Cell Culturing in Porous Hydroxyapatite  

Science Conference Proceedings (OSTI)

About this Abstract. Meeting, Materials Science & Technology 2011. Symposium, Next Generation Biomaterials. Presentation Title, Human Fetal Liver Cell ...

344

PIA - Human Resources System/Payroll System | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

System PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory PIA - INL SECURITY INFORMATION MANAGEMENT SYSTEM BUSINESS ENCLAVE...

345

DOE Jobs Online (Hiring Manager), Office of Human Capitol Management...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

of Human Capitol Management Innovation and Solutions More Documents & Publications MOX Services Unclassified Information System PIA, National Nuclear Services Administration...

346

The Quality of Law: Judicial Incentives, Legal Human Capital and the Evolution of Law  

E-Print Network (OSTI)

into systemic error-reducing legal human capital. In thenition, legal human capital reduces legal error: @K 2 human capital and judicial error. Even if

Hadfield, Gillian

2007-01-01T23:59:59.000Z

347

Evidence for Cardiomyocyte Renewal in Humans  

SciTech Connect

It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of {sup 14}C, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 20 to 0.3% at the age of 75. Less than 50% of cardiomyocytes are exchanged during a normal lifespan. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work towards the development of therapeutic strategies aiming to stimulate this process in cardiac pathologies.

Bergmann, O; Bhardwaj, R D; Bernard, S; Zdunek, S; Barnabe-Heider, F; Walsh, S; Zupicich, J; Alkass, K; Buchholz, B A; Druid, H; Jovinge, S; Frisen, J

2008-10-14T23:59:59.000Z

348

Architect and Human Measure; the integration role  

E-Print Network (OSTI)

The architect plays an essential role in making solutions, which fit with the human measure. During the long product creation chain the human measure is easily lost. The role of the architect is to integrate understanding of the customer world with know-how of the solution (technology) world. The architect quickly iterates many stakeholder viewpoints to achieve a satisfying solutions from many, seemingly conflicting, viewpoints. Distribution This article or presentation is written as part of the Gaud project. The Gaud project philosophy is to improve by obtaining frequent feedback. Frequent feedback is pursued by an open creation process. This document is published as intermediate or nearly mature version to get feedback. Further distribution is allowed as long as the document remains complete and unchanged. All Gaud documents are available at: http://www.extra.research.philips.com/natlab/sysarch/ version: 0.2 status: planned 1st April 2004 1

Gerrit Muller

2001-01-01T23:59:59.000Z

349

Bridging Resilience Engineering and Human Reliability Analysis  

SciTech Connect

There has been strong interest in the new and emerging field called resilience engineering. This field has been quick to align itself with many existing safety disciplines, but it has also distanced itself from the field of human reliability analysis. To date, the discussion has been somewhat one-sided, with much discussion about the new insights afforded by resilience engineering. This paper presents an attempt to address resilience engineering from the perspective of human reliability analysis (HRA). It is argued that HRA shares much in common with resilience engineering and that, in fact, it can help strengthen nascent ideas in resilience engineering. This paper seeks to clarify and ultimately refute the arguments that have served to divide HRA and resilience engineering.

Ronald L. Boring

2010-06-01T23:59:59.000Z

350

Justice and the Human Genome Project  

Science Conference Proceedings (OSTI)

Most of the essays gathered in this volume were first presented at a conference, Justice and the Human Genome, in Chicago in early November, 1991. The goal of the, conference was to consider questions of justice as they are and will be raised by the Human Genome Project. To achieve its goal of identifying and elucidating the challenges of justice inherent in genomic research and its social applications the conference drew together in one forum members from academia, medicine, and industry with interests divergent as rate-setting for insurance, the care of newborns, and the history of ethics. The essays in this volume address a number of theoretical and practical concerns relative to the meaning of genomic research.

Murphy, T.F.; Lappe, M. (eds.)

1992-01-01T23:59:59.000Z

351

SCHOOL OF ENGINEERING 2009-2011 RESEARCH REPORT  

E-Print Network (OSTI)

that Release Therapeutic Agents to modulate Inflammation Following Spinal Cord Injury," National Institutes Crosslinking Effects on Bone Fragility," National Institutes of health (NIh) / The National Institute of Dental in Cortical Bone: Effect of mineral Content," J mechanical Behavior of Biomedical materials, 3(5), 405

Salama, Khaled

352

Some aspects regarding human error assessment in resilient sociotechnical systems  

Science Conference Proceedings (OSTI)

The paper focuses on a human reliability analysis (HRA) that provides estimates of relative frequencies for human errors in particular critical tasks, highlighting the exposed areas of the system in which the improvements will be beneficial. The dynamic ... Keywords: human factor qualitative, quantitative analysis, risk, sociotechnical system

Gabriela Tont; Luige Vladareanu; Radu Adrian Munteanu; Dan George Tont

2009-11-01T23:59:59.000Z

353

Similarity based retrieval from a 3D human database  

Science Conference Proceedings (OSTI)

In this paper, we describe a framework for similarity based retrieval from a 3D human database. Our technique is based on both body and head shape representation and retrieval based on similarity of both of them. The 3D human database used in our study ... Keywords: body and head shape, human database, retrieval, similarity

Afzal Godil; Sandy Ressler

2005-07-01T23:59:59.000Z

354

College of Health, Education, and Human Development DEVELOPMENT  

E-Print Network (OSTI)

; and the Outdoor Laboratory. Collaboration within the col- lege between academics and community outreach services98 College of Health, Education, and Human Development 98 COLLEGE OF HEALTH, EDUCATION, AND HUMAN DEVELOPMENT The College of Health, Education, and Human Development provides students the means by which

Stuart, Steven J.

355

Nepal: Dealing with a Human Rights Crisis  

E-Print Network (OSTI)

; (b) accepting appointment of a Special Rapporteur and issuing a standing invitation to the thematic mechanisms of the UN Commission on Human Rights to visit Nepal; (c) allowing the International Committee of the Red Cross (ICRC) to fulfil its... rank and ability to collate, evaluate and act on the information gathered by monitors; (b) appointing a Special Rapporteur; and (c) encouraging the royal government to issue a standing invitation to the thematic mechanisms of the Commission...

International Crisis Group

2005-03-24T23:59:59.000Z

356

Human Reliability Analysis for Small Modular Reactors  

Science Conference Proceedings (OSTI)

Because no human reliability analysis (HRA) method was specifically developed for small modular reactors (SMRs), the application of any current HRA method to SMRs represents tradeoffs. A first- generation HRA method like THERP provides clearly defined activity types, but these activity types do not map to the human-system interface or concept of operations confronting SMR operators. A second- generation HRA method like ATHEANA is flexible enough to be used for SMR applications, but there is currently insufficient guidance for the analyst, requiring considerably more first-of-a-kind analyses and extensive SMR expertise in order to complete a quality HRA. Although no current HRA method is optimized to SMRs, it is possible to use existing HRA methods to identify errors, incorporate them as human failure events in the probabilistic risk assessment (PRA), and quantify them. In this paper, we provided preliminary guidance to assist the human reliability analyst and reviewer in understanding how to apply current HRA methods to the domain of SMRs. While it is possible to perform a satisfactory HRA using existing HRA methods, ultimately it is desirable to formally incorporate SMR considerations into the methods. This may require the development of new HRA methods. More practicably, existing methods need to be adapted to incorporate SMRs. Such adaptations may take the form of guidance on the complex mapping between conventional light water reactors and small modular reactors. While many behaviors and activities are shared between current plants and SMRs, the methods must adapt if they are to perform a valid and accurate analysis of plant personnel performance in SMRs.

Ronald L. Boring; David I. Gertman

2012-06-01T23:59:59.000Z

357

Broadband Dielectric Spectroscopy on Human Blood  

E-Print Network (OSTI)

Dielectric spectra of human blood reveal a rich variety of dynamic processes. Achieving a better characterization and understanding of these processes not only is of academic interest but also of high relevance for medical applications as, e.g., the determination of absorption rates of electromagnetic radiation by the human body. The dielectric properties of human blood are studied using broadband dielectric spectroscopy, systematically investigating the dependence on temperature and hematocrit value. By covering a frequency range from 1 Hz to 40 GHz, information on all the typical dispersion regions of biological matter is obtained. We find no evidence for a low-frequency relaxation (alpha-relaxation) caused, e.g., by counterion diffusion effects as reported for some types of biological matter. The analysis of a strong Maxwell-Wagner relaxation arising from the polarization of the cell membranes in the 1-100 MHz region (beta-relaxation) allows for the test of model predictions and the determination of various intrinsic cell properties. In the microwave region beyond 1 GHz, the reorientational motion of water molecules in the blood plasma leads to another relaxation feature (gamma-relaxation). Between beta- and gamma-relaxation, significant dispersion is observed, which, however, can be explained by a superposition of these relaxation processes and is not due to an additional delta-relaxation often found in biological matter. Our measurements provide dielectric data on human blood of so far unsurpassed precision for a broad parameter range. All data are provided in electronic form to serve as basis for the calculation of the absorption rate of electromagnetic radiation and other medical purposes. Moreover, by investigating an exceptionally broad frequency range, valuable new information on the dynamic processes in blood is obtained.

M. Wolf; R. Gulich; P. Lunkenheimer; A. Loidl

2011-05-25T23:59:59.000Z

358

Humidity, human factors, and the energy shortage  

SciTech Connect

Little is known about humidity and its effects on human performance. An increased emphasis is being placed on the role of humidification and dehumidification of our working and living environments on performance. This paper was presented at a Symposium on Humidity Control and Energy Conservation, held during ASHRAE's 1975 Semiannual Meeting in Atlantic City, New Jersey. Other papers were: Residential Humidification vs. Energy Conservation, by J. A. Selvaag and Humidity Control and Energy Conservation, by Dr. G. Shavit.

Rohles, F.H. Jr.

1975-04-01T23:59:59.000Z

359

Are some human ecosystems self-defeating?  

Science Conference Proceedings (OSTI)

Complex patterns of human behaviour are difficult to capture in agent-based simulations of socio-ecological systems. Even knowing each individual agent's strategy at one point in time may not help when trying to predict the collective behaviour of certain ... Keywords: Agent-based models, Bar problem, Cartesians and Stochasts, Evolutionarily stable strategies, Minority game, Self-defeating systems, Socio-ecological systems

David Batten

2007-05-01T23:59:59.000Z

360

HUMAN RESOURCES MANUAL SECTION 5: STUDENT EMPLOYEES  

E-Print Network (OSTI)

. University Work-Study Program 1. An undergraduate work-study student employee must be enrolled for at least EMPLOYEES 2 | P a g e S e c t i o n 4 University Work-Study Program (continued) 4. Hiring departments shouldHUMAN RESOURCES MANUAL SECTION 5: STUDENT EMPLOYEES 1 | P a g e S e c t i o n 4 Program

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

high impact Designing a human-powered  

E-Print Network (OSTI)

to the local mill and pay to have it ground into flour, or grind it themselves by hand with a mortar and pestleLow tech, high impact Designing a human-powered grain mill for Africa Ten-year-old Solomoni Mafuta) to a diesel-pow- ered mill to be ground. The time-consuming task has pulled him away from his studies

Endres. William J.

362

Human-system Interfaces for Automatic Systems  

SciTech Connect

Automation is ubiquitous in modern complex systems, and commercial nuclear- power plants are no exception. Automation is applied to a wide range of functions including monitoring and detection, situation assessment, response planning, and response implementation. Automation has become a 'team player' supporting personnel in nearly all aspects of system operation. In light of its increasing use and importance in new- and future-plants, guidance is needed to conduct safety reviews of the operator's interface with automation. The objective of this research was to develop such guidance. We first characterized the important HFE aspects of automation, including six dimensions: levels, functions, processes, modes, flexibility, and reliability. Next, we reviewed literature on the effects of all of these aspects of automation on human performance, and on the design of human-system interfaces (HSIs). Then, we used this technical basis established from the literature to identify general principles for human-automation interaction and to develop review guidelines. The guidelines consist of the following seven topics: automation displays, interaction and control, automation modes, automation levels, adaptive automation, error tolerance and failure management, and HSI integration. In addition, our study identified several topics for additional research.

OHara, J.M.; Higgins,J. (BNL); Fleger, S.; Barnes V. (NRC)

2010-11-07T23:59:59.000Z

363

Human factors engineering program review model  

SciTech Connect

The staff of the Nuclear Regulatory Commission is performing nuclear power plant design certification reviews based on a design process plan that describes the human factors engineering (HFE) program elements that are necessary and sufficient to develop an acceptable detailed design specification and an acceptable implemented design. There are two principal reasons for this approach. First, the initial design certification applications submitted for staff review did not include detailed design information. Second, since human performance literature and industry experiences have shown that many significant human factors issues arise early in the design process, review of the design process activities and results is important to the evaluation of an overall design. However, current regulations and guidance documents do not address the criteria for design process review. Therefore, the HFE Program Review Model (HFE PRM) was developed as a basis for performing design certification reviews that include design process evaluations as well as review of the final design. A central tenet of the HFE PRM is that the HFE aspects of the plant should be developed, designed, and evaluated on the basis of a structured top-down system analysis using accepted HFE principles. The HFE PRM consists of ten component elements. Each element in divided into four sections: Background, Objective, Applicant Submittals, and Review Criteria. This report describes the development of the HFE PRM and gives a detailed description of each HFE review element.

Not Available

1994-07-01T23:59:59.000Z

364

Desenvolvimento e avaliaçăo in vitro de um cimento de fosfato de calcio.  

E-Print Network (OSTI)

??Calcium phosphate bone cements are ceramics materials that present biocompatibility because of their chemical composition similar to the human bone, and bioactivity, promoting osteocunduction. Due… (more)

Claudenete Vieira Leal

2006-01-01T23:59:59.000Z

365

Dynamic Human Reliability Analysis: Benefits and Challenges of Simulating Human Performance  

Science Conference Proceedings (OSTI)

To date, there has been considerable work on dynamic event trees and other areas related to dynamic probabilistic safety assessment (PSA). The counterpart to these efforts in human reliability analysis (HRA) has centered on the development of specific methods to account for the dynamic nature of human performance. In this paper, the author posits that the key to dynamic HRA is not in the development of specific methods but in the utilization of cognitive modeling and simulation to produce a framework of data that may be used in quantifying the likelihood of human error. This paper provides an overview of simulation approaches to HRA; reviews differences between first, second, and dynamic generation HRA; and outlines potential benefits and challenges of this approach.

R. L. Boring

2007-06-01T23:59:59.000Z

366

Stanford Synchrotron Radiation Lightsource  

NLE Websites -- All DOE Office Websites (Extended Search)

Nanoscale Examination of Microdamage in Sheep Cortical Bone Nanoscale Examination of Microdamage in Sheep Cortical Bone April 2013 SSRL Science Summary by Lori Ann White, SLAC Office of Communications Figure Lead-uranyl acetate staining of damage morphologies in notched bone samples. (A, B) Staining of lacunae and canaliculi in the compressive region seen in 20 of the 23 samples; (C, D) Cross hatching damage around notch tip in the tensile region observed in 10 of 23 samples; (E, F) Crack propagating from notch tip in the tensile region in a single sample. Staining appears white due to high attenuation of lead-uranyl acetate, with bone tissue appearing grey and voids black. Scale bar: A,C,E = 50 ÎĽm; B,D,F = 5 ÎĽm. Sample created in the longitudinal plane of the bone.] An important factor contributing to bone fractures is the accumulation of

367

No evidence for in vivo induction of genomic instability in bone marrow cells collected from mice exposed to low-dose 137Cs Îł rays:  

NLE Websites -- All DOE Office Websites (Extended Search)

Rithidech et al, 2006 1 Rithidech et al, 2006 1 No evidence for in vivo induction of genomic instability in bone marrow cells collected from mice exposed to low-dose 137 Cs Îł rays: Kanokporn Noy Rithidech 1 , Chatchanok Loetchutinat 1 , Louise Honikel 1 , and Elbert B. Whorton 2 1 Pathology Department, Stony Brook University, Stony Brook, NY 11794-8691 2 Molecular Epidemiology Research Program, University of Texas Medical Branch at Galveston, TX 77555-1153 Assessment of potential health risks associated with exposure to low-dose radiation (at doses below or equal to 0.1 Gy) is still a challenging public health issue. It is therefore important to improve our understanding of potential induction of genomic instability in vivo by this low-dose range because it has been widely suggested that elevation of genomic instability also elevates cancer

368

Modified total body irradiation as a planned second high-dose therapy with stem cell infusion for patients with bone-based malignancies  

SciTech Connect

Purpose: To estimate the maximum tolerated dose of hyperfractionated total marrow irradiation (TMI) as a second consolidation after high-dose chemotherapy with autologous or syngeneic blood stem cell transfusion for patients with bone/bone marrow-based malignant disease. Patients and Methods: Fifty-seven patients aged 3-65 years (median, 45 years), including 21 with multiple myeloma, 24 with breast cancer, 10 with sarcoma, and 2 with lymphoma, were treated with 1.5 Gy administered twice daily to a total dose of 12 Gy (n = 27), 13.5 Gy (n = 12), and 15 Gy (n = 18). Median time between the 2 transplants was 105 days (range, 63-162 days). Results: All patients engrafted neutrophils (median, Day 11; range, Day 9-23) and became platelet independent (median, Day 9; range, Day 7-36). There were 5 cases of Grade 3-4 regimen-related pulmonary toxicity, 1 at 12 Gy, and 4 at 15 Gy. Complete responses, partial responses, and stabilizations were achieved in 33%, 26%, and 41% of patients, respectively. Kaplan-Meier estimates of 5-year progression-free survival and overall survival for 56 evaluable patients are 24% and 36%, respectively. Median time of follow-up among survivors was 96 months (range, 77-136 months). Conclusion: Total marrow irradiation as a second myeloablative therapy is feasible. The estimated maximum tolerated dose for TMI in a tandem transplant setting was 13.5 Gy. Because 20% of patients are surviving at 8 years free of disease, further studies of TMI are warranted.

Zaucha, Renata E. [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Buckner, Dean C. [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Barnett, Todd [The Swedish Hospital Medical Center, Cancer Institute, Seattle, WA (United States); Holmberg, Leona A. [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Gooley, Ted [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Hooper, Heather A. P.A.-C. [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Maloney, David G. [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Appelbaum, Frederick [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States); Bensinger, William I. [Fred Hutchinson Cancer Research Center, University of Washington, Clinical Research Division, Seattle, WA (United States)]. E-mail: wbensing@fhcrc.org

2006-01-01T23:59:59.000Z

369

Human health implications of geothermal energy  

DOE Green Energy (OSTI)

Environmental problems consist of the release of noncondensable gases and vapors, disposal of saline fluids, possible land subsidence and enhanced seismicity, noise, accidents such as well blowouts, and socioeconomic impacts. The most important issue related to human health is believed to be the emission of noncondensable gases, including hydrogen sulfide, mercury, and radon. Based upon data at The Geysers, California, Power Plant, emissions of mercury and radon are not large enough to result in concerns for human health. Hydrogen sulfide emissions, however, have resulted in complaints of odor annoyance and health impairment. These complaints have been caused by exposure to levels of up to approximately 0.1 ppmv in ambient air. This is above the California standard of 0.03 ppmv. Achievement of this standard may not eliminate annoyance complaints, as the odor detection threshold is lognormally distributed and about 20% of the population can detect hydrogen sulfide at levels of 0.002 ppmv. Abatement systems for hydrogen sulfide have been utilized at The Geysers since 1975. This has resulted in an increase of occupational illness caused by exposure to the abatement chemicals and wastes. More effective, and hopefully safer, abatement systems are now being tested. Occupational hazards are evaluated; the more significant ones are exposure to toxic chemicals and hazardous materials and noise. Available occupational illness data are summarized; there clearly indicate that the most significant cause of illness has been exposure to the chemicals and wastes associated with hydrogen sulfide abatement.

Anspaugh, L.R.; Hahn, J.L.

1979-08-21T23:59:59.000Z

370

QuarkNet Workshop: Beyond Human Error  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Error Human Error QuarkNet Workshop for High School Science Teachers 8:30 am to 4:00 pm, August 1 -3, 2012 at Fermi National Accelerator Laboratory This was a three-day workshop for high school science teachers. Measurement and error are key ingredients for all science applications. Both align with the Next Generation Science Standards, but many high school students struggle to understand the importance of error analysis and prevention. Over the three days we examined multiple experiments going on at Fermilab and discussed the ways that scientists take measurements and reduce error on these projects. Participants met and worked with scientists from Fermilab and University of Chicago to look at how error analysis takes place at Fermilab and bridged those ideas into high school classes. Teachers discussed lesson plans available at Fermilab and their own methods of teaching error analysis. Additionally, participants heard from high school students who participated in summer research as they presented their findings and linked students' learning back to the teachers' understanding of error recognition and analysis.

371

EPRI-CRIEPI Joint Human Factors Program Summary Report: Joint EPRI-CRIEPI Human Factors Studies  

Science Conference Proceedings (OSTI)

The EPRI-CRIEPI Joint Human Factors Program developed an array of intervention products that provide logical solutions to performance problems confronting nuclear power plant maintenance workers. These products, designed to reduce the incidence of errors and increase productivity, range from job performance cards to a software-based authoring system for training material.

1995-01-24T23:59:59.000Z

372

Science-Based Simulation Model of Human Performance for Human Reliability Analysis  

Science Conference Proceedings (OSTI)

Human reliability analysis (HRA), a component of an integrated probabilistic risk assessment (PRA), is the means by which the human contribution to risk is assessed, both qualitatively and quantitatively. However, among the literally dozens of HRA methods that have been developed, most cannot fully model and quantify the types of errors that occurred at Three Mile Island. Furthermore, all of the methods lack a solid empirical basis, relying heavily on expert judgment or empirical results derived in non-reactor domains. Finally, all of the methods are essentially static, and are thus unable to capture the dynamics of an accident in progress. The objective of this work is to begin exploring a dynamic simulation approach to HRA, one whose models have a basis in psychological theories of human performance, and whose quantitative estimates have an empirical basis. This paper highlights a plan to formalize collaboration among the Idaho National Laboratory (INL), the University of Maryland, and The Ohio State University (OSU) to continue development of a simulation model initially formulated at the University of Maryland. Initial work will focus on enhancing the underlying human performance models with the most recent psychological research, and on planning follow-on studies to establish an empirical basis for the model, based on simulator experiments to be carried out at the INL and at the OSU.

Dana L. Kelly; Ronald L. Boring; Ali Mosleh; Carol Smidts

2011-10-01T23:59:59.000Z

373

Human Factors Guidance for Control Room and Digital Human-System Interface Design and Modification  

Science Conference Proceedings (OSTI)

Operators of nuclear power plants face a significant challenge designing and modifying control rooms that will be produced at various stages of instrumentation and control (I&C) modernization. This report provides guidance on planning, specifying, designing, implementing, operating, maintaining, and training for modernized control rooms and digital human-system interfaces.

2005-12-08T23:59:59.000Z

374

UNDP-Human Development Reports | Open Energy Information  

Open Energy Info (EERE)

UNDP-Human Development Reports UNDP-Human Development Reports Jump to: navigation, search Tool Summary LAUNCH TOOL Name: UNDP-Human Development Reports Agency/Company /Organization: United Nations Development Programme Topics: Co-benefits assessment Resource Type: Dataset, Publications Website: hdr.undp.org/en/ UNDP-Human Development Reports Screenshot References: UNDP-Human Development Reports[1] Summary "Available online on November 4th, the 2010 Report continues the tradition of pushing the frontiers of development thinking. For the first time since 1990, the Report looks back rigorously at the past several decades and identifies often surprising trends and patterns with important lessons for the future. These varied pathways to human development show that there is no single formula for sustainable progress-and that impressive long-term

375

Human Resources | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Human Resources Human Resources Integrated Support Center (ISC) ISC Home About Services Freedom of Information Act (FOIA) Privacy Act Categorical Exclusion Determinations Contact Information Integrated Support Center Roxanne Purucker U.S. Department of Energy 9800 S. Cass Avenue Argonne, IL 60439 P: (630) 252-2110 Larry Kelly U.S. Department of Energy 200 Administration Road Oak Ridge, TN 37830 P: (865) 576-0885 Services Human Resources Print Text Size: A A A RSS Feeds FeedbackShare Page Related Links Forms External link Office of Chief Human Capital Officer USA Jobs External link The ISC Human Resources Services develops and implements a comprehensive human capital program to facilitate the acquisition, development and retention of a technically competent, diverse workforce that meets the

376

Human Resources | U.S. DOE Office of Science (SC)  

Office of Science (SC) Website

Human Human Resources Human Resources and Administration (HRA) HRA Home Leadership Organization Chart .pdf file (27KB) Human Resources Administration SC Correspondence Control Center (SC CCC) Contact Information Human Resources and Administration U.S. Department of Energy SC-48/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-1133 F: (301) 903-1299 Human Resources Print Text Size: A A A RSS Feeds FeedbackShare Page Workforce Planning, Organizational Analysis and Classification: OHRA works with organizations to assess the current workforce, predict the future workforce, identify gaps, and develop new strategies to address those gaps. It provides vital data for management to use when preparing their staffing plans. The staff reviews positions for appropriate

377

Population Physiologically-Based Pharmacokinetic Modeling for the Human  

NLE Websites -- All DOE Office Websites (Extended Search)

Population Physiologically-Based Pharmacokinetic Modeling for the Human Population Physiologically-Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB 153 with Consideration of Worldwide Human Biomonitoring Results Title Population Physiologically-Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB 153 with Consideration of Worldwide Human Biomonitoring Results Publication Type Journal Article Year of Publication 2008 Authors Redding, Laurel E., Michael D. Sohn, Thomas E. McKone, Shu-Li Wang, Dennis P. H. Hsieh, and Raymond S. H. Yang Journal Environmental Health Perspectives Volume 116 Issue 12 Pagination 1629-1634 Keywords bayesian inference, body burden, environmental chemistry, exposure & risk group, human milk biomonitoring, indoor environment department, lactational transfer, pcb 153, physiologically-based pharmacokinetic modeling, pollutant fate and transport modeling, poly-chlorinated biphenyls, reverse dosimetry

378

Human factors aspects of advanced instrumentation in the nuclear industry  

SciTech Connect

An important consideration in regards to the use of advanced instrumentation in the nuclear industry is the interface between the instrumentation system and the human. A survey, oriented towards identifying the human factors aspects of digital instrumentation, was conducted at a number of United States (US) and Canadian nuclear vendors and utilities. Human factors issues, subsumed under the categories of computer-generated displays, controls, organizational support, training, and related topics were identified. 20 refs., 2 tabs.

Carter, R.J.

1989-01-01T23:59:59.000Z

379

Human Radiation Experiments: Roadmap to the Project: ACHRE Report  

NLE Websites -- All DOE Office Websites (Extended Search)

Members and Staff Acknowledgments Documentary Note Preface Introduction - The Atomic Century Part I - Ethics of Human Subjects Research: A Historical Perspective Overview...

380

Human Radiation Experiments: Roadmap to the Project: ACHRE Report  

NLE Websites -- All DOE Office Websites (Extended Search)

research involving healthy subjects: human experimentation conducted in conjunction with atomic bomb tests. More than 200,000 service personnel--now known as atomic...

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Human Computation Tasks with Global Constraints Haoqi Zhang1  

E-Print Network (OSTI)

4Microsoft Research Cambridge, MA Pittsburgh, PA Cambridge, MA Redmond, WA {hq, kgajos, parkes.3 [Information Interfaces and Presentation]: Group and Organization Interfaces General Terms Design, Human

Parkes, David C.

382

Nonproliferation Human Capital Development in Malaysia | National Nuclear  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Capital Development in Malaysia | National Nuclear Human Capital Development in Malaysia | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > Nonproliferation Human Capital Development in Malaysia Nonproliferation Human Capital Development in Malaysia Posted By NNSA Public Affairs NNSA Blog Photo Credit: National University of Malaysia

383

POLICY BULLETIN: POL-5- Declassification Instruction "25X1-human"  

Energy.gov (U.S. Department of Energy (DOE))

Provides instructions on the appropriate action to take when classification guide topics or source documents cite "25X1-human" declassification instructions.

384

Experts Recommend Measures to Reduce Human Error in ...  

Science Conference Proceedings (OSTI)

... 34 recommendations addressing the problems resulting from ... is understood that some human error is inevitable ... that openness about errors leads to ...

2012-02-21T23:59:59.000Z

385

Human Exposure to Ultrafine Particles-Sources, Concentrations...  

NLE Websites -- All DOE Office Websites (Extended Search)

Human Exposure to Ultrafine Particles-Sources, Concentrations, Indoor-Outdoor Relationships, and Mitigation Techniques Speaker(s): Lance Wallace Date: July 22, 2013 - 12:00pm -...

386

Human Health Risk & Environmental Analysis | Clean Energy | ORNL  

NLE Websites -- All DOE Office Websites (Extended Search)

to examine the interplay between human health and environmental risks associated with energy production, hazardous waste, national security and natural disasters. Research...

387

Functional Organization of Human Visual Cortex in Occipital Polymicrogyria  

E-Print Network (OSTI)

retinotopic representations in human visual cortex revealed by fMRI. Acta Psychol 107:229­247. Ono M, Kubic S

Dumoulin, Serge O.

388

Groundwater Resources Assessment under the Pressures of Humanity...  

Open Energy Info (EERE)

Groundwater Resources Assessment under the Pressures of Humanity and Climate Change (GRAPHIC) Jump to: navigation, search Tool Summary Name: Groundwater Resources Assessment under...

389

Oakland University Human Health Science Building Geothermal Heat...  

Open Energy Info (EERE)

Last modified on July 22, 2011. Project Title Oakland University Human Health Science Building Geothermal Heat Pump Systems Project Type Topic 1 Recovery Act - Geothermal...

390

The sorcerer and the apprentice. Human-computer interaction today  

Science Conference Proceedings (OSTI)

Keywords: discontinuous control, fault dectection, human-computer interface, linguistic support, logical control, magic manipulation, man-machine interface, password, robot control

W. Oberschelp

1998-03-01T23:59:59.000Z

391

DOE human genome program contractor-grantee workshop VI  

SciTech Connect

Research is presented from the workshop on the Human Genome Project. Topics include sequencing, genetic mapping, informatics, ethical and legal issues, and infrastructure.

NONE

1997-10-01T23:59:59.000Z

392

DOE Openess: Human Radiation Experiments - Roadmap to the Project  

NLE Websites -- All DOE Office Websites (Extended Search)

Radiation Experiments: Roadmap to the Project DOE Shield DOE Openness: Human Radiation Experiment Roadmap to the Project Roadmap to the Project Home Roadmap What's New Search HREX...

393

"OUT OF AFRICA: GENETICS AND HUMAN MIGRATIONS", Prof. Gyan Bhanot...  

NLE Websites -- All DOE Office Websites (Extended Search)

Calendar Events January 7, 2012, 9:30am Science On Saturday MBG Auditorium "OUT OF AFRICA: GENETICS AND HUMAN MIGRATIONS", Prof. Gyan Bhanot, Department of Molecular Biology,...

394

United States Patent Office 2013 Patents for Humanity Honorable...  

NLE Websites -- All DOE Office Websites (Extended Search)

United States Patent Office 2013 Patents for Humanity Honorable Mention April 11, 2013 UV Waterworks development team The Unites States Post Office cited Lawrence Berkeley National...

395

The Oak Ridge Institute for Science and Education Human Subjects...  

NLE Websites -- All DOE Office Websites (Extended Search)

Overview Forms Membership List Operating Procedures (pdf) "How to" for PIs (pdf) The Oak Ridge Institute for Science and Education (ORISE) Human Subjects Research Program Oak...

396

Quantifying Greenhouse Gas Emissions from Human Activities: Toward...  

NLE Websites -- All DOE Office Websites (Extended Search)

Quantifying Greenhouse Gas Emissions from Human Activities: Toward Verification of Emissions Control Compliance Speaker(s): Marc Fischer Date: April 29, 2010 - 12:00pm Location:...

397

DOE Strategic Human Capital Plan (FY 2006 - 2011)  

NLE Websites -- All DOE Office Websites (Extended Search)

accomplishing the Energy's core mission. They are without doubt, DOE' most important asset Jeff Pon Chief Human Capital Officer iv Executive Summary The Department of Energy...

398

HUMAN SECURITY AND DEVELOPMENT: THE CASE OF CAMBODIA .  

E-Print Network (OSTI)

??Human security was promoted in 1994 by the UNDP as a concept embracing not only freedom from war and violence (or personal security), but also… (more)

Quinn, Peter Thomas

2010-01-01T23:59:59.000Z

399

Meeting the Human Capital Management Challenge  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

A A A M M A A N N A A G G E E R R ' ' S S D D E E S S K K R R E E F F E E R R E E N N C C E E O O N N H H U U M M A A N N C C A A P P I I T T A A L L M M A A N N A A G G E E M M E E N N T T F F L L E E X X I I B B I I L L I I T T I I E E S S © Microsoft Office Online ClipArt October 2010 Office of the Chief Human Capital Officer 2 Table of Contents INTRODUCTION --------------------------------------------------------------------------------------- 3 RECRUITMENT INCENTIVE ------------------------------------------------------------------------- 5 RECRUITMENT INCENTIVE FAQs ----------------------------------------------------------------- 6 RELOCATION INCENTIVE --------------------------------------------------------------------------- 8 RELOCATION INCENTIVE FAQs-------------------------------------------------------------------- 9

400

Human Resource Directors (HRD) | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Resource Resource Directors (HRD) Human Resource Directors (HRD) Name Organization Phone Number E-Mail Brian Carter Bonneville Power Administration (BPA) (503) 230-4527 becarter@bpa.gov Linda Brunner (Acting) Consolidated Business Center (EM) (513) 246-0518 linda.brunner@emcbc.doe.gov Connie Nottingham (Acting) Richland Operations Office (EM) (509) 373-6288 connie.nottingham@rl.doe.gov Helene Taylor Savannah River Operations (EM) (803) 952-8123 helene.taylor@srs.gov Bruce Wynn National Energy Technology Laboratory (NETL/FE) (412) 386-5259 bruce.wynn@netl.doe.gov Shandon Davis Strategic Petroleum Reserve Proj. Office (SPRO/FE) (504) 734-4382 shandon.davis@spr.doe.gov Edith Ramos Office of Inspector General (OIG) (202) 586-2470 edith.ramos@hq.doe.gov

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Dynamics of Hippocampal Neurogenesis in Adult Humans  

NLE Websites -- All DOE Office Websites (Extended Search)

Hippocampal Hippocampal Neurogenesis in Adult Humans Kirsty L. Spalding, 1,8 Olaf Bergmann, 1,8 Kanar Alkass, 1,2 Samuel Bernard, 3 Mehran Salehpour, 4 Hagen B. Huttner, 1,5 Emil Bostro ¨ m, 1 Isabelle Westerlund, 1 Ce ´ line Vial, 3 Bruce A. Buchholz, 6 Go ¨ ran Possnert, 4 Deborah C. Mash, 7 Henrik Druid, 2 and Jonas Frise ´ n 1, * 1 Department of Cell and Molecular Biology 2 Department of Oncology-Pathology Karolinska Institutet, 171 77 Stockholm, Sweden 3 Institut Camille Jordan, CNRS UMR 5208, University of Lyon, 69622 Villeurbanne, France 4 Department of Physics and Astronomy, Ion Physics, Uppsala University, 751 20 Sweden 5 Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany 6 Center for Accelerator Mass Spectrometry, Lawrence Livermore National Laboratory, 7000 East Avenue L-397, Livermore, CA 94550, USA 7 Department of Neurology,

402

2011-2015 Human Capital Management Plan  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

The Office of Legacy Management (LM) needs skilled and engaged staff to accomplish our mission and The Office of Legacy Management (LM) needs skilled and engaged staff to accomplish our mission and carry out our responsibilities to the American people. This (HCMP or Plan) shows how we intend to recruit, hire, train, develop, and retain such employees. Our differs from previous versions not only in enhanced visual appeal (including photos of LM staff and sites) but also in showing direct links between our objectives, strategies, and activities and the human capital issues most important to President Obama's Administration, the Department, and our own management and staff. We thank the LM Management Team and other staff who contributed to and commented on this plan. We all know that for the LM HCMP to succeed we must continually evaluate our progress and adjust our plan

403

HUMAN RELIABILITY ANALYSIS FOR COMPUTERIZED PROCEDURES  

SciTech Connect

This paper provides a characterization of human reliability analysis (HRA) issues for computerized procedures in nuclear power plant control rooms. It is beyond the scope of this paper to propose a new HRA approach or to recommend specific methods or refinements to those methods. Rather, this paper provides a review of HRA as applied to traditional paper-based procedures, followed by a discussion of what specific factors should additionally be considered in HRAs for computerized procedures. Performance shaping factors and failure modes unique to computerized procedures are highlighted. Since there is no definitive guide to HRA for paper-based procedures, this paper also serves to clarify the existing guidance on paper-based procedures before delving into the unique aspects of computerized procedures.

Ronald L. Boring; David I. Gertman; Katya Le Blanc

2011-09-01T23:59:59.000Z

404

Human Factors Aspects of Advanced Process Control  

E-Print Network (OSTI)

Energy conservation practices, such as heat recovery and integration, require that many chemical and related processes use advanced control systems. Many of the more advanced process control strategies and algorithms can cause operator confusion, leading to incorrect operator actions and negating the advantages of the advanced control. If the operator makes a mistake and upsets the process, or fails to respond correctly to a process upset, the loss can exceed the possible savings of the advanced control. Further, the experience can result in the operator not using the control capability in the future. Display and man/machine interface techniques, based on an understanding of human factors and of an operator's typical analysis of a process, can be used to present information to the operator in a manner which will prevent confusion. This paper discusses techniques for selecting and displaying process and control information to the operator.

Shaw, J. A.

1986-06-01T23:59:59.000Z

405

Automatic Interpretation of Human Head Movements  

E-Print Network (OSTI)

This paper describes a complete face tracking system that interprets human head movements in real time. The system combines motion analysis with reliable and efficient object recognition strategies. It classifies head movements as "yes" (nodding head), "no" (shaking head) or "nothing" (still head). The system's skill allows contactless man-machine interaction, thus giving access to a number of new applications. 1 Introduction As industrialization proceeds, the importance of interactions between man and machine increases rapidly. Information flow from machine to man has become comfortable and direct in recent years due to tremendous progresses in computer graphics. Information flow from man to machine, on the other hand, is still on a low level. It is restricted to moving mice, pressing buttons, and typing character sequences on a keyboard. Automatic interpretation of gestures and facial expressions could reduce this imbalance and is therefore of central interrest for current and futu...

Bichsel Pentland; M. Bichsel; A. P. Pentland

1993-01-01T23:59:59.000Z

406

Insights from Human/Mouse genome comparisons  

SciTech Connect

Large-scale public genomic sequencing efforts have provided a wealth of vertebrate sequence data poised to provide insights into mammalian biology. These include deep genomic sequence coverage of human, mouse, rat, zebrafish, and two pufferfish (Fugu rubripes and Tetraodon nigroviridis) (Aparicio et al. 2002; Lander et al. 2001; Venter et al. 2001; Waterston et al. 2002). In addition, a high-priority has been placed on determining the genomic sequence of chimpanzee, dog, cow, frog, and chicken (Boguski 2002). While only recently available, whole genome sequence data have provided the unique opportunity to globally compare complete genome contents. Furthermore, the shared evolutionary ancestry of vertebrate species has allowed the development of comparative genomic approaches to identify ancient conserved sequences with functionality. Accordingly, this review focuses on the initial comparison of available mammalian genomes and describes various insights derived from such analysis.

Pennacchio, Len A.

2003-03-30T23:59:59.000Z

407

A Comparison of hospitality human resources practices in Greece and the United States: An analysis of human resources practices and the potential effects on service quality.  

E-Print Network (OSTI)

??Proper approaches to managing an organization’s human resources are becoming more and more scientific. Most human resource managers would agree that the selection, training, and… (more)

Philippakos, John

2009-01-01T23:59:59.000Z

408

The History of Human Bondage and An Instructional Strategy Resource Guide for Teaching History through the Humanities.  

E-Print Network (OSTI)

?? This thesis focuses on the history of human bondage through historiography and original research and provides an instructional strategy resource guide for teaching history… (more)

Insalaco, David L.

409

Fifty Years of THERP and Human Reliability Analysis  

SciTech Connect

In 1962 at a Human Factors Society symposium, Alan Swain presented a paper introducing a Technique for Human Error Rate Prediction (THERP). This was followed in 1963 by a Sandia Laboratories monograph outlining basic human error quantification using THERP and, in 1964, by a special journal edition of Human Factors on quantification of human performance. Throughout the 1960s, Swain and his colleagues focused on collecting human performance data for the Sandia Human Error Rate Bank (SHERB), primarily in connection with supporting the reliability of nuclear weapons assembly in the US. In 1969, Swain met with Jens Rasmussen of Risř National Laboratory and discussed the applicability of THERP to nuclear power applications. By 1975, in WASH-1400, Swain had articulated the use of THERP for nuclear power applications, and the approach was finalized in the watershed publication of the NUREG/CR-1278 in 1983. THERP is now 50 years old, and remains the most well known and most widely used HRA method. In this paper, the author discusses the history of THERP, based on published reports and personal communication and interviews with Swain. The author also outlines the significance of THERP. The foundations of human reliability analysis are found in THERP: human failure events, task analysis, performance shaping factors, human error probabilities, dependence, event trees, recovery, and pre- and post-initiating events were all introduced in THERP. While THERP is not without its detractors, and it is showing signs of its age in the face of newer technological applications, the longevity of THERP is a testament of its tremendous significance. THERP started the field of human reliability analysis. This paper concludes with a discussion of THERP in the context of newer methods, which can be seen as extensions of or departures from Swain’s pioneering work.

Ronald L. Boring

2012-06-01T23:59:59.000Z

410

Toward humanoid manipulation in human-centred environments  

Science Conference Proceedings (OSTI)

In order for humanoid robots to enter human-centred environments, it is indispensable to equip them with manipulative, perceptive and communicative skills necessary for real-time interaction with the environment and humans. The goal of our work is to ... Keywords: Control architecture, Grasp planning, Mechatronics, Motion planning, Object recognition and localization

T. Asfour; P. Azad; N. Vahrenkamp; K. Regenstein; A. Bierbaum; K. Welke; J. Schröder; R. Dillmann

2008-01-01T23:59:59.000Z

411

Mobile human-robot teaming with environmental tolerance  

Science Conference Proceedings (OSTI)

We demonstrate that structured light-based depth sensing with standard perception algorithms can enable mobile peer-to-peer interaction between humans and robots. We posit that the use of recent emerging devices for depth-based imaging can enable robot ... Keywords: gesture recognition, human-robot interaction, person following

Matthew M. Loper; Nathan P. Koenig; Sonia H. Chernova; Chris V. Jones; Odest C. Jenkins

2009-03-01T23:59:59.000Z

412

Human gait analyzed by complex and interconnected system  

Science Conference Proceedings (OSTI)

This paper presents the activities of our team in order to establish a configuration for biomechanical studies and to evaluate the human gait, for different persons and different environmental conditions. We also presented a methodology for recording ... Keywords: force plate, human gait, motion

Mihaela Baritz; Diana Cotoros

2007-11-01T23:59:59.000Z

413

Characterizing pairwise contact patterns in human contact networks  

Science Conference Proceedings (OSTI)

We use a counting process representation of the pairwise contact process to analyze pairwise contact patterns. Studying two real-world traces, we find that the pairwise contact patterns have three characteristics. First, human contact patterns are influenced ... Keywords: Human contact networks, Markov modulated Poisson process, Pairwise contact process

Lintao Yang; Hao Jiang; Sai Wang; Lin Wang; Yuan Fang

2012-05-01T23:59:59.000Z

414

CHI '11 Extended Abstracts on Human Factors in Computing Systems  

Science Conference Proceedings (OSTI)

Over the last year or so, we have been blessed with the challenge, the opportunity, and the distinct pleasure of organizing the CHI 2011 Conference on Human Factors in Computing Systems, the premier international conference for the field of human-computer ...

Desney Tan; Bo Begole; Wendy A. Kellogg

2011-05-01T23:59:59.000Z

415

Life Cycle Human Capital Formation, Search Intensity, and Wage Dynamics  

E-Print Network (OSTI)

This paper presents and estimates a unified model where both human capital investment and job search are endogenized. This unification not only enables me to quantify the relative contributions of each mechanism to life cycle wage dynamics, but also to investigate potential interactions between human capital investment and job search. Within the unified framework, the expectation of rising rental rates of human capital through searching in the future gives workers more incentive to invest in human capital. In the meantime, unemployed workers reduce their reservation rates to leave unemployment quickly to take advantage of human capital accumulation on the job. The results show that these interactions are well supported by data. Allowing for these interactions as well as heterogeneity in search technology, the unified model predicts that both human capital accumulation and job search contribute significantly to the wage growth over the life cycle with human capital accumulation accounting for 40 % of total wage growth and job search accounting for 50%. The remaining 10 % is due to the interactions of the two forces. Furthermore, job search dominates wage growth earlier in the life cycle while human capital accumulation dominates later in the life cycle. ?This paper is one of the chapters in my Ph.D. thesis. I thank my committee members, Audra Bowlus, Hiroyuki Kasahara, and Lance Lochner for their continuous guidance and support. I would also like to thank Chris Robinson, Fabien Postel-Vinay, Todd Stinebrickner, Ben Lester as well as

Huju Liu

2009-01-01T23:59:59.000Z

416

Experiences with collaborative, distributed predictive human performance modeling  

Science Conference Proceedings (OSTI)

Although predictive human performance modeling has been researched for 30 years in HCI, to our knowledge modeling has been conducted as a solitary task of one modeler or, occasionally, two modelers working in tight face-to-face collaboration. In contrast, ... Keywords: cogtool, efficiency, klm, predictive human performance modeling, usability evaluation

Bonnie John; Sonal Starr; Brian Utesch

2012-05-01T23:59:59.000Z

417

Radiation Analysis for the Human Lunar Return Mission  

Science Conference Proceedings (OSTI)

An analysis of the radiation hazards that are anticipated on an early Human Lunar Return (HLR) mission in support of NASA deep space exploration activities is presented. The HLR mission study emphasized a low cost lunar return to expand human capabilities ...

Wilson J. W.; Simonsen L. C.; Shinn J. L.; Dubey R. R.; Jordan W.; Kim M.

1997-09-01T23:59:59.000Z

418

Fish, Omega 3 and Human Health, 2nd Edition  

Science Conference Proceedings (OSTI)

The second edition of Fish, Omega-3 and Human Health reaffirms that the essential fatty acids in the foods we eat form hormones that have powerful effects on human life. While many find it hard to believe that a simple change of diet can affect so many asp

419

Henry S. Dennison, Elton Mayo, and Human Relations historiography  

Science Conference Proceedings (OSTI)

The conventional wisdom in management thought is that Human Relations was the intellectual progeny of Elton Mayo and his associates, arising out of the fabled Hawthorne 'experiments' and marked a distinct intellectual break from Scientific Management.This ... Keywords: Elton Mayo, Henry S. Dennison, Human Relations, Scientific Management, historiography

Kyle Bruce

2006-05-01T23:59:59.000Z

420

Establishing and maintaining long-term human-computer relationships  

Science Conference Proceedings (OSTI)

This research investigates the meaning of “human-computer relationship” and presents techniques for constructing, maintaining, and evaluating such relationships, based on research in social psychology, sociolinguistics, communication and ... Keywords: Human-computer interaction, embodied conversational agent, relational agent, social interface

Timothy W. Bickmore; Rosalind W. Picard

2005-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

A Mathematical Model for a Vibrating Human Head  

Science Conference Proceedings (OSTI)

In this paper, a mathematical model has been formulated to study the vibration of the human head. In the mathematical analysis of the model, the skull is considered as an anisotropic spherical shell and brain matter is represented as an inviscid compressible ... Keywords: Anisotropic, Human Head, Laplace Transformation, Skull Vibration, Stress Distribution

J. C. Misra; S. Dandapat; S. Adhikary

2010-04-01T23:59:59.000Z

422

BURNING BURIED SUNSHINE: HUMAN CONSUMPTION OF ANCIENT SOLAR ENERGY  

E-Print Network (OSTI)

BURNING BURIED SUNSHINE: HUMAN CONSUMPTION OF ANCIENT SOLAR ENERGY JEFFREY S. DUKES Department of as a vast store of solar energy from which society meets >80% of its current energy needs. Here, using of ancient solar energy decline, humans are likely to use an increasing share of modern solar resources. I

Dukes, Jeffrey

423

Experiences from measuring human mobility using Bluetooth inquiring devices  

Science Conference Proceedings (OSTI)

We present an analysis of human mobility measurements using Bluetooth devices. A number of data traces from such measurements have been made publicly available for the benefit of the research community. However, the limitations of the measurement approaches ... Keywords: Bluetooth, data traces, experimentation, human mobility, opportunistic networking

Erik Nordström; Christophe Diot; Richard Gass; Per Gunningberg

2007-06-01T23:59:59.000Z

424

Energy and Development: Is Energy a Basic Human Right?  

E-Print Network (OSTI)

Energy and Development: Is Energy a Basic Human Right? Skype/Video presentation for senior pupils national Laboratory/DTU Denmark #12;Is energy a basic human right? · What is energy? ­ the ability to make something happen · Different kinds of energy ­ or energy carriers - fuels · What do we use energy for

425

A photon accurate model of the human eye  

Science Conference Proceedings (OSTI)

A photon accurate model of individual cones in the human eye perceiving images on digital display devices is presented. Playback of streams of pixel video data is modeled as individual photon emission events from within the physical substructure of each ... Keywords: display devices, eye models, human eye cone models, schematic eyes, synthesized retina

Michael F. Deering

2005-07-01T23:59:59.000Z

426

Human computation: a survey and taxonomy of a growing field  

Science Conference Proceedings (OSTI)

The rapid growth of human computation within research and industry has produced many novel ideas aimed at organizing web users to do great things. However, the growth is not adequately supported by a framework with which to understand each new system ... Keywords: crowdsourcing, data mining, human computation, literature review, social computing, survey, taxonomy

Alexander J. Quinn; Benjamin B. Bederson

2011-05-01T23:59:59.000Z

427

Scientific Bibliography on Human Powered Submarines, through 1997  

E-Print Network (OSTI)

powered marine vehicles Poole, PK Human power: the technicalpower generation in an underwater environment Merry, SL et al IN: Oceans '88: A Partnership of Marinemarine conditions and the capacity for superior performance. H-P submarines: design parameters Poole, PK Human Power:

Brueggeman, Peter

1997-01-01T23:59:59.000Z

428

Importance of physical interaction between human and robot for therapy  

Science Conference Proceedings (OSTI)

Mental health care of the elderly people is a common problem in advanced countries. Recently, high technology has developed robots for use not only in factories but also for our living environment. In particular, human interactive robots for psychological ... Keywords: elderly care, human-robot interaction, mental commitment robot, robot therapy

Takanori Shibata

2011-07-01T23:59:59.000Z

429

Local control stations: Human engineering issues and insights  

SciTech Connect

The objective of this research project was to evaluate current human engineering at local control stations (LCSs) in nuclear power plants, and to identify good human engineering practices relevant to the design of these operator interfaces. General literature and reports of operating experience were reviewed to determine the extent and type of human engineering deficiencies at LCSs in nuclear power plants. In-plant assessments were made of human engineering at single-function as well as multifunction LCSs. Besides confirming the existence of human engineering deficiencies at LCSs, the in-plant assessments provided information about the human engineering upgrades that have been made at nuclear power plants. Upgrades were typically the result of any of three influences regulatory activity, broad industry initiatives such as INPO, and specific in-plant programs (e.g. activities related to training). It is concluded that the quality of LCSs is quite variable and might be improved if there were greater awareness of good practices and existing human engineering guidance relevant to these operator interfaces, which is available from a variety of sources. To make such human engineering guidance more readily accessible, guidelines were compiled from such sources and included in the report as an appendix.

Brown, W.S.; Higgins, J.C.; O`Hara, J.M. [Brookhaven National Lab., Upton, NY (United States)

1994-09-01T23:59:59.000Z

430

Metric selection for evaluating human supervisory control of unmanned vehicles  

Science Conference Proceedings (OSTI)

Broad metric classes were proposed in the literature in order to facilitate metric selection for evaluating human-autonomous vehicle interaction. However, there still lacks a systematic method for selecting an efficient set of metrics from the many metrics ... Keywords: AHP, analytic hierarchy process, experiments, human supervisory control, metric quality, metrics

Birsen Donmez; M. L. Cummings

2010-09-01T23:59:59.000Z

431

Robust continuous prediction of human emotions using multiscale dynamic cues  

Science Conference Proceedings (OSTI)

Designing systems able to interact with humans in a natural manner is a complex and far from solved problem. A key aspect of natural interaction is the ability to understand and appropriately respond to human emotions. This paper details our response ... Keywords: affective computing, dynamic features, facial expressions, feature selection, multimodal fusion

Jérémie Nicolle; Vincent Rapp; Kévin Bailly; Lionel Prevost; Mohamed Chetouani

2012-10-01T23:59:59.000Z

432

IMAGES IN EMBRYOLOGY............................................................................ Development of the human heart: days 1521  

E-Print Network (OSTI)

............................................................................ Development of the human heart: days 15­21 I n this series, three dimensional computer graphics are used to present the anatomical structures involved in the different stages of normal human heart development visit: www.virtual-heart- development.univ-rennes1.fr During the third week of gestation (days 15

Paris-Sud XI, Université de

433

Experiment Hazard Class 7.5 - Human Tissue/Materials  

NLE Websites -- All DOE Office Websites (Extended Search)

5 - Human Tissue/Materials 5 - Human Tissue/Materials Applicability This hazard classification applies to all experiments involving biohazards requiring the use of human tissue/materials. Other hazard classifications and their associated hazard controls may also apply to experiments in this hazard class. Human tissue/materials must also be evaluated for their biosafety level and as such will have to go through the process for that particular Biosafety Level. IMPORTANT NOTE: For non-Argonne employees, all experiment protocols involving human tissue are required to be either reviewed or declared exempt from review by their home institution's Institutional Review Board (IRB). Documentation of the review should be filed in the ESAF system and with the APS BioSafety Officer (BSO) (Nena Moonier 2-8504,

434

T-547: Microsoft Windows Human Interface Device (HID) Vulnerability |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

547: Microsoft Windows Human Interface Device (HID) Vulnerability 547: Microsoft Windows Human Interface Device (HID) Vulnerability T-547: Microsoft Windows Human Interface Device (HID) Vulnerability February 1, 2011 - 3:20am Addthis PROBLEM Microsoft Windows Human Interface Device (HID) Vulnerability. PLATFORM: Microsoft 2003 SP2, Vista SP2, 2008 SP2, XP SP3, 7; and prior service packs ABSTRACT: Microsoft Windows does not properly warn the user before enabling additional Human Interface Device (HID) functionality over USB, which allows user-assisted attackers to execute arbitrary programs via crafted USB data, as demonstrated by keyboard and mouse data sent by malware on a Smartphone that the user connected to the computer. reference LINKS: Security Lab: Reference CVE-2011-0638 CVE Details: Reference CVE-2011-0638 Mitre Reference: CVE-2011-0638

435

Evaluating the applicability of current models of workload to peer-based human-robot teams  

Science Conference Proceedings (OSTI)

Human-Robot peer-based teams are evolving from a far-off possibility into a reality. Human Performance Moderator Functions (HPMFs) can be used to predict human behavior by incorporating the effects of internal and external influences such as fatigue ... Keywords: human performance modeling, human-robot peer-based teams

Caroline E. Harriott; Tao Zhang; Julie A. Adams

2011-03-01T23:59:59.000Z

436

Let's keep in touch online: a Facebook aware virtual human interface  

Science Conference Proceedings (OSTI)

A virtual human is an effective interface for interacting with users and plays an important role in carrying out certain tasks. As social networking sites are getting more and more popular, we propose a Facebook aware virtual human. The social networking ... Keywords: Dialogue, Human-virtual human interaction, Social networking sites, Virtual humans

Gengdai Liu; Shantanu Choudhary; Juzheng Zhang; Nadia Magenenat-Thalmann

2013-09-01T23:59:59.000Z

437

Science and the Human Good, Schmitt Lecture, Notre Dame, April 21, 2009 Science and the Human Good  

E-Print Network (OSTI)

Science and the Human Good, Schmitt Lecture, Notre Dame, April 21, 2009 Science and the Human Good: How to Think Philosophically about the Place of Values in Science Don Howard Department of Philosophy and Program in History and Philosophy of Science Arthur J. Schmitt Lecture Center for Ethics and Culture

Howard, Don

438

A view-based real-time human action recognition system as an interface for human computer interaction  

Science Conference Proceedings (OSTI)

This paper describes a real-time human action recognition system that can track multiple persons and recognize distinct human actions through image sequences acquired from a single fixed camera. In particular, when given an image, the system segments ... Keywords: HCI, adaptive background subtraction, motion history image, view-based action recognition

Jin Choi; Yong-Il Cho; Taewoo Han; Hyun S. Yang

2007-09-01T23:59:59.000Z

439

Human Performance Optimization: Emerging Management Issues and Artificial Intelligence Methods: Volume 2: Forecasting Human Behavior in a Constrained Environment  

Science Conference Proceedings (OSTI)

Human performance optimization is critical to all aspects of the energy enterprise. This four-volume report presents findings from a review of the human performance challenges and opportunities created by the changing nature of the energy industry, its workforce, and its work environments.

2001-10-03T23:59:59.000Z

440

Cortical-Hippocampal Auditory Processing Identified by Magnetoencephalography  

Science Conference Proceedings (OSTI)

We recorded magnetic and electrical responses simultaneously in an auditory detection task to elucidate the brain areas involved in auditory processing.Target stimuli evoked magnetic fields peaking at approximately the same latency of around about 400 ...

Nobuyuki Nishitani; Takashi Nagamine; Naohito Fujiwara; Shogo Yazawa; Hiroshi Shibasaki

1998-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Dynamics of Adipocyte Turnover in Humans  

Science Conference Proceedings (OSTI)

Obesity is increasing in an epidemic fashion in most countries and constitutes a public health problem by enhancing the risk for cardiovascular disease and metabolic disorders such as type 2 diabetes. Owing to the increase in obesity, life expectancy may start to decrease in developed countries for the first time in recent history. The factors determining fat mass in adult humans are not fully understood, but increased lipid storage in already developed fat cells is thought to be most important. We show that adipocyte number is a major determinant for the fat mass in adults. However, the number of fat cells stays constant in adulthood in lean and obese and even under extreme conditions, indicating that the number of adipocytes is set during childhood and adolescence. To establish the dynamics within the stable population of adipocytes in adults, we have measured adipocyte turnover by analyzing the integration of {sup 14}C derived from nuclear bomb tests in genomic DNA. Approximately 10% of fat cells are renewed annually at all adult ages and levels of body mass index. Neither adipocyte death nor generation rate is altered in obesity, suggesting a tight regulation of fat cell number that is independent of metabolic profile in adulthood. The high turnover of adipocytes establishes a new therapeutic target for pharmacological intervention in obesity.

Spalding, K; Arner, E; Westermark, P; Bernard, S; Buchholz, B; Bergmann, O; Blomqvist, L; Hoffstedt, J; Naslund, E; Britton, T; Concha, H; Hassan, M; Ryden, M; Frisen, J; Arner, P

2007-07-16T23:59:59.000Z

442

Human Factors Aspects of Operating Small Reactors  

DOE Green Energy (OSTI)

The nuclear-power community has reached the stage of proposing advanced reactor designs to support power generation for decades to come. They are considering small modular reactors (SMRs) as one approach to meet these energy needs. While the power output of individual reactor modules is relatively small, they can be grouped to produce reactor sites with different outputs. Also, they can be designed to generate hydrogen, or to process heat. Many characteristics of SMRs are quite different from those of current plants, and so may require a concept of operations (ConOps) that also is different. The U.S. Nuclear Regulatory Commission (NRC) has begun examining the human factors engineering- (HFE) and ConOps- aspects of SMRs; if needed, they will formulate guidance to support SMR licensing reviews. We developed a ConOps model, consisting of the following dimensions: Plant mission; roles and responsibilities of all agents; staffing, qualifications, and training; management of normal operations; management of off-normal conditions and emergencies; and, management of maintenance and modifications. We are reviewing information on SMR design to obtain data about each of these dimensions, and have identified several preliminary issues. In addition, we are obtaining operations-related information from other types of multi-module systems, such as refineries, to identify lessons learned from their experience. Here, we describe the project's methodology and our preliminary findings.

OHara, J.M.; Higgins, J.; Deem, R. (BNL); Xing, J.; DAgostino, A. (NRC)

2010-11-07T23:59:59.000Z

443

Air humidity requirements for human comfort  

SciTech Connect

Upper humidity limits for the comfort zone determined from two recently presented models for predicting discomfort due to skin humidity and insufficient respiratory cooling are proposed. The proposed limits are compared with the maximum permissible humidity level prescribed in existing standards for the thermal indoor environment. The skin humidity model predicts discomfort as a function of the relative humidity of the skin, which is determined by existing models for human heat and moisture transfer based on environmental parameters, clothing characteristics, and activity level. The respiratory model predicts discomfort as a function of the driving forces for heat loss from the respiratory tract, namely, the temperature and humidity of the surrounding air. An upper humidity limit based on a relative skin humidity of 0.54, corresponding to 20% dissatisfied, results in a maximum permissible humidity level near 100% RH. The requirements for respiratory comfort are much more stringent and result in lower permissible indoor air humidities. Compared with the upper humidity limit specified in existing thermal comfort standards, e.g., ASHRAE Addendum 55a, the humidity limit based on skin humidity was less restrictive and the humidity limit based on respiratory comfort was far more restrictive.

Toftum, J.; Fanger, P.O.

1999-07-01T23:59:59.000Z

444

Diopside (CaO-MgO-2SiO2)-fluorapatite (9CaO-3P2O5-CaF2) glass-ceramics: Potential materials for bone tissue engineering  

SciTech Connect

Glass-ceramics in the diopside (CaMgSi2O6) - fluorapatite [Ca5(PO4)3F] system are potential candidates for restorative dental and bone implant materials. In the present study, a series of glasses along diopside - fluorapatite binary system have been prepared with varying diopside/fluorapatite ratios for their potential applications in bone tissue engineering. The glasses were obtained from compositions with fluorapatite contents varying between 0-40 wt.%. The sintering ability and crystallization kinetics of as obtained amorphous glasses have been studied through hot-stage microscopy (HSM) and differential thermal analysis (DTA), respectively while crystalline phase evolution in sintered GCs has been followed by X-ray diffraction (XRD) adjoined with Rietveld-R.I.R. technique and scanning electron microscopy (SEM). Further, biodegradation and apatite forming ability of glass-ceramics were investigated by immersion of glass-ceramic discs in simulated body fluid (SBF) solution while chemical degradation and weight loss of glass-ceramics were studied by immersion in Tris-HCl in accordance with standard ISO 10993-14. The addition of fluorapatite (10-25 wt.%) in diopside glass system significantly enhanced the sintering ability of glass-ceramics and improved their apatite forming ability along with their biodegradation behaviour. Moreover, the in vitro cellular responses to glass-ceramics showed good cell viability and significant stimulation of osteoblastic differentiation, suggesting the possible use of the glass-ceramics for bone regeneration.

Kansal, Ishu; Goel, Ashutosh; Tulyaganov, Dilshat U.; Pascual, Maria J.; Lee, Hye-Young; Kim, Hae-Won; Ferreira, Jose M.

2011-08-18T23:59:59.000Z

445

[Multiplex mapping of human cDNAs]. Technical progress report  

SciTech Connect

We have tested and implemented several protocols to increase productivity for mapping expressed sequence tags EST sequences to human chromosomes. These protocols include adopting PRIMER which permits utilization of batch files, as the standard software for PCR primer design; adding a human 21-only cell line to the NIGMS panel No. 1 to improve discrimination in discordancy analyses involving chromosome 21, adding a monochromosomal hybrid panel to facilitate chromosome assignment of sequences that are amplified from more than 1 chromosome; combining the products of multiple PCR reactions for electrophoretic analysis (pseudoplexing); routinely multiplexing PCR reactions; and automating data entry and analysis as much as possible. We have applied these protocols to assign an overall total of 132 human brain CDNA sequences to individual human chromosomes. PCR primers were designed from ESTS and tested for specific amplification from human genomic DNA. DNA was then amplified using DNA from somatic cell hybrid mapping panels as templates. The amplification products were identified using an automated fluorescence detection system. Chromosomal assignments were made by discordancy analysis. The localized cDNAs include 2 for known human genes, 2 that map to 2 different human chromosomes, and 25 for cDNAs matching existing database records.

Nierman, W.C.

1992-11-01T23:59:59.000Z

446

Enhancement of mechanical strength of TiO{sub 2}/high-density polyethylene composites for bone repair with silane-coupling treatment  

SciTech Connect

Mechanical properties of composites made up of high-density polyethylene (HDPE) and silanated TiO{sub 2} particles for use as a bone-repairing material were investigated in comparison with those of the composites of HDPE with unsilanized TiO{sub 2} particles. The interfacial morphology and interaction between silanated TiO{sub 2} and HDPE were analyzed by means of Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). The absorption in spectral bands related to the carboxyl bond in the silane-coupling agent, the vinyl group in the HDPE, and the formation of the ether bond was studied in order to assess the influence of the silane-coupling agent. The SEM micrograph showed that the 'bridging effect' between HDPE and TiO{sub 2} was brought about by the silane-coupling agent. The use of the silane-coupling agent and the increase of the hot-pressing pressure for shaping the composites facilitated the penetration of polymer into cavities between individual TiO{sub 2} particles, which increased the density of the composite. Therefore, mechanical properties such as bending yield strength and Young's modulus increased from 49 MPa and 7.5 GPa to 65 MPa and 10 GPa, respectively, after the silane-coupling treatment and increase in the hot-pressing pressure.

Hashimoto, Masami [Japan Fine Ceramics Center, 2-4-1 Mutsuno, Atsuta-ku, Nagoya 456-8587 (Japan)]. E-mail: masami@jfcc.or.jp; Takadama, Hiroaki [Japan Fine Ceramics Center, 2-4-1 Mutsuno, Atsuta-ku, Nagoya 456-8587 (Japan)]. E-mail: takadama@jfcc.or.jp; Mizuno, Mineo [Japan Fine Ceramics Center, 2-4-1 Mutsuno, Atsuta-ku, Nagoya 456-8587 (Japan)]. E-mail: mizuno@jfcc.or.jp; Kokubo, Tadashi [Research Institute for Science and Technology, Chubu University, 1200 Matsumoto-cho, Kasugai 487-8501 (Japan)]. E-mail: kokubo@isc.chubu.ac.jp

2006-03-09T23:59:59.000Z

447

Detection of occult infection following total joint arthroplasty using sequential technetium-99m HDP bone scintigraphy and indium-111 WBC imaging  

SciTech Connect

Preoperative exclusion or confirmation of periprosthetic infection is essential for correct surgical management of patients with suspected infected joint prostheses. The sensitivity and specificity of (/sup 111/In)WBC imaging in the diagnosis of infected total joint prostheses was examined in 28 patients and compared with sequential (/sup 99m/Tc)HDP/(/sup 111/In)WBC scintigraphy and aspiration arthrography. The sensitivity of preoperative aspiration cultures was 12%, with a specificity of 81% and an accuracy of 58%. The sensitivity of (/sup 111/In)WBC imaging alone was 100%, with a specificity of 50% and an accuracy of 65%. When correlated with the bone scintigraphy and read as sequential (/sup 99m/Tc)HDP/(/sup 111/In)WBC imaging, the sensitivity was 88%, specificity 95%, and accuracy 93%. This study demonstrates that (/sup 111/In)WBC imaging is an extremely sensitive imaging modality for the detection of occult infection of joint prostheses. It also demonstrates the necessity of correlating (/sup 111/In)WBC images with (/sup 99m/Tc)HDP skeletal scintigraphy in the detection of occult periprosthetic infection.

Johnson, J.A.; Christie, M.J.; Sandler, M.P.; Parks, P.F. Jr.; Homra, L.; Kaye, J.J.

1988-08-01T23:59:59.000Z

448

The Development of A Human Systems Simulation Laboratory: Strategic Direction  

SciTech Connect

The Human System Simulation Laboratory (HSSL) at the Idaho National Laboratory is one of few facilities of its kind that allows human factors researchers to evaluate various aspects of human performance and human system interaction for proposed reactor designs and upgrades. A basic system architecture, physical configuration and simulation capability were established to enable human factors researchers to support multiple, simultaneous simulations and also different power plant technologies. Although still evolving in terms of its technical and functional architecture, the HSSL is already proving its worth in supporting current and future nuclear industry needs for light water reactor sustainability and small modular reactors. The evolution of the HSSL is focused on continual physical and functional refinement to make it a fully equipped, reconfigurable facility where advanced research, testing and validation studies can be conducted on a wider range of reactor technologies. This requires the implementation of additional plant models to produce empirical research data on human performance with emerging human-system interaction technologies. Additional beneficiaries of this information include system designers and HRA practitioners. To ensure that results of control room crew studies will be generalizable to the existing and evolving fleet of US reactors, future expansion of the HSSL may also include other SMR plant models, plant-specific simulators and a generic plant model aligned to the current generation of pressurized water reactors (PWRs) and future advanced reactor designs. Collaboration with industry partners is also proving to be a vital component of the facility as this helps to establish a formal basis for current and future human performance experiments to support nuclear industry objectives. A long-range Program Plan has been developed for the HSSL to ensure that the facility will support not only the Department of Energy’s Light Water Reactor Sustainability Program, but also to provide human factors guidance for all future developments of the nuclear industry.

Jacques Hugo; Katya le Blanc; David Gertman

2012-07-01T23:59:59.000Z

449

Exploratory studies of human sensorimotor learning with system identification and stochastic optimal control  

E-Print Network (OSTI)

b) Shows the average human error over one particular trialb) Shows the average human error over one particular trialIs a histogram of average human tracking error over several

Simpkins, Charles Alexander

2009-01-01T23:59:59.000Z

450

Learning and inferring human intentions : explorations of driver attention and interactivity  

E-Print Network (OSTI)

the vehicle around a turn. Human error, as opposed to anyof this accident. Indeed, human error had even been cited inNearly two centuries later, human errors are still at the

Doshi, Anup

2010-01-01T23:59:59.000Z

451

Physically-proximal human-robot collaboration for air and space applications  

Science Conference Proceedings (OSTI)

In Aerospace applications, human safety is of paramount importance given harsh environmental conditions that require persistent electromechanical life support. The resulting inherent proximity between humans and "robotic support" requires effective communication ... Keywords: airspace management, human-robot interaction, space robotics

Ella M. Atkins

2007-08-01T23:59:59.000Z

452

Understanding the global architecture of gene regulation in human cells through analysis of chromatin signatures  

E-Print Network (OSTI)

annotation of functional chromatin signatures in the humanA. Thomson, and Bing Ren. Chromatin States in Human ES CellsApproach to Finding Common Chromatin Signatures in the Human

Hon, Gary Chung

2009-01-01T23:59:59.000Z

453

Human equivalent antenna model for HF exposures: analytical versus numerical approach  

Science Conference Proceedings (OSTI)

In this paper, the human exposure to HF radiation is analyzed using the simplified human equivalent antenna model featuring analytical and numerical approach, respectively. Namely, the human body is represented by an equivalent receiving straight thin ...

Dragan Poljak; Silvestar Sesnic; Ivana Zulim

2009-09-01T23:59:59.000Z

454

Analysis comparing robotic to human TRUPACT unloading at WIPP  

SciTech Connect

This economic analysis compares human and robotic TRUPACT unloading at the Waste Isolation Pilot Plant. Robots speed up the unloading process, reduce human labor requirements, and reduce human exposure to radiation. The analysis shows that benefit/cost ratios are greater than one for most cases using government economic parameters. This suggests that robots are an attractive option for the TRUPACT application, from a government perspective. Rates of return on capital investment are below 15% for most cases using private economic parameters. Thus, robots are not an attractive option for this application, from a private enterprise perspective.

Edenburn, M.W.

1992-01-01T23:59:59.000Z

455

Generic Error Model of Human-Robot Interaction  

E-Print Network (OSTI)

Wrong human-robot interactions are at the origin of severe damages. Safety requirements ask the analysis of these interactions. At first, erroneous interactions have to be identified. In this paper, we propose to use UML (Unified Modeling Language) to specify human robot interaction. Then, generic error models, associated with the message feature provided by UML, are presented. These error models allow interaction errors to be automatically deduced from the modeling of the human-robot interactions. The use of these generic error models is illustrated on a medical robot for teleechography.

J. Guiochet; et al.

2004-01-01T23:59:59.000Z

456

Buried waste integrated demonstration human engineered control station. Final report  

SciTech Connect

This document describes the Human Engineered Control Station (HECS) project activities including the conceptual designs. The purpose of the HECS is to enhance the effectiveness and efficiency of remote retrieval by providing an integrated remote control station. The HECS integrates human capabilities, limitations, and expectations into the design to reduce the potential for human error, provides an easy system to learn and operate, provides an increased productivity, and reduces the ultimate investment in training. The overall HECS consists of the technology interface stations, supporting engineering aids, platform (trailer), communications network (broadband system), and collision avoidance system.

Not Available

1994-09-01T23:59:59.000Z

457

International Associations at the Nexus of Globalization, Religion, and Human Rights.  

E-Print Network (OSTI)

??Abstract International Associations at the Nexus of Globalization, Religion, and Human Rights By David V. Brewington Religion and human rights are often analyzed in the… (more)

Brewington, David V

2011-01-01T23:59:59.000Z

458

Groundwater Resources Assessment under the Pressures of Humanity and  

Open Energy Info (EERE)

Groundwater Resources Assessment under the Pressures of Humanity and Groundwater Resources Assessment under the Pressures of Humanity and Climate Change (GRAPHIC) Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Groundwater Resources Assessment under the Pressures of Humanity and Climate Change (GRAPHIC) Agency/Company /Organization: United Nations Educational Scientific and Cultural Organization Sector: Climate, Water Topics: Co-benefits assessment, Resource assessment Resource Type: Publications Website: unesdoc.unesco.org/images/0015/001507/150730e.pdf References: Groundwater Resources Assessment under the Pressures of Humanity and Climate Change (GRAPHIC)[1] "The GRAPHIC project seeks to improve our understanding of how groundwater contributes to the global water cycle and thus how it supports ecosystems

459

Evaluating human fecal contamination sources in Kranji Reservoir Catchment, Singapore  

E-Print Network (OSTI)

Singapore government through its Public Utilities Board is interested in opening Kranji Reservoir to recreational use. However, water courses within the Kranji Reservoir catchment contain human fecal indicator bacteria ...

Nshimyimana, Jean Pierre

2010-01-01T23:59:59.000Z

460

The sequence and analysis of duplication rich human chromosome 16  

Science Conference Proceedings (OSTI)

We report here the 78,884,754 base pairs of finished human chromosome 16 sequence, representing over 99.9 percent of its euchromatin. Manual annotation revealed 880 protein coding genes confirmed by 1,637 aligned transcripts, 19 tRNA genes, 341 pseudogenes and 3 RNA pseudogenes. These genes include metallothionein, cadherin and iroquois gene families, as well as the disease genes for polycystic kidney disease and acute myelomonocytic leukemia. Several large-scale structural polymorphisms spanning hundreds of kilobasepairs were identified and result in gene content differences across humans. One of the unique features of chromosome 16 is its high level of segmental duplication, ranked among the highest of the human autosomes. While the segmental duplications are enriched in the relatively gene poor pericentromere of the p-arm, some are involved in recent gene duplication and conversion events which are likely to have had an impact on the evolution of primates and human disease susceptibility.

Martin, Joel; Han, Cliff; Gordon, Laurie A.; Terry, Astrid; Prabhakar, Shyam; She, Xinwei; Xie, Gary; Hellsten, Uffe; Man Chan, Yee; Altherr, Michael; Couronne, Olivier; Aerts, Andrea; Bajorek, Eva; Black, Stacey; Blumer, Heather; Branscomb, Elbert; Brown, Nancy C.; Bruno, William J.; Buckingham, Judith M.; Callen, David F.; Campbell, Connie S.; Campbell, Mary L.; Campbell, Evelyn W.; Caoile, Chenier; Challacombe, Jean F.; Chasteen, Leslie A.; Chertkov, Olga; Chi, Han C.; Christensen, Mari; Clark, Lynn M.; Cohn, Judith D.; Denys, Mirian; Detter, John C.; Dickson, Mark; Dimitrijevic-Bussod, Mira; Escobar, Julio; Fawcett, Joseph J.; Flowers, Dave; Fotopulos, Dea; Glavina, Tijana; Gomez, Maria; Gonzales, Eidelyn; Goodstein, David; Goodwin, Lynne A.; Grady, Deborah L.; Grigoriev, Igor; Groza, Matthew; Hammon, Nancy; Hawkins, Trevor; Haydu, Lauren; Hildebrand, Carl E.; Huang, Wayne; Israni, Sanjay; Jett, Jamie; Jewett, Phillip E.; Kadner, Kristen; Kimball, Heather; Kobayashi, Arthur; Krawczyk, Marie-Claude; Leyba, Tina; Longmire, Jonathan L.; Lopez, Frederick; Lou, Yunian; Lowry, Steve; Ludeman, Thom; Mark, Graham A.; Mcmurray, Kimberly L.; Meincke, Linda J.; Morgan, Jenna; Moyzis, Robert K.; Mundt, Mark O.; Munk, A. Christine; Nandkeshwar, Richard D.; Pitluck, Sam; Pollard, Martin; Predki, Paul; Parson-Quintana, Beverly; Ramirez, Lucia; Rash, Sam; Retterer, James; Ricke, Darryl O.; Robinson, Donna L.; Rodriguez, Alex; Salamov, Asaf; Saunders, Elizabeth H.; Scott, Duncan; Shough, Timothy; Stallings, Raymond L.; Stalvey, Malinda; Sutherland, Robert D.; Tapia, Roxanne; Tesmer, Judith G.; Thayer, Nina; Thompson, Linda S.; Tice, Hope; Torney, David C.; Tran-Gyamfi, Mary; Tsai, Ming; Ulanovsky, Levy E.; Ustaszewska, Anna; Vo, Nu; White, P. Scott; Williams, Albert L.; Wills, Patricia L.; Wu, Jung-Rung; Wu, Kevin; Yang, Joan; DeJong, Pieter; Bruce, David; Doggett, Norman; Deaven, Larry; Schmutz, Jeremy; Grimwood, Jane; Richardson, Paul; et al.

2004-08-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Manager's Desk Reference on Human Capital Management Flexibilities |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Manager's Desk Reference on Human Capital Management Flexibilities Manager's Desk Reference on Human Capital Management Flexibilities Manager's Desk Reference on Human Capital Management Flexibilities The purpose of this document is to provide DOE managers and supervisors with information on available flexibilities that can be used in day-to-day human capital management activities, especially those bearing on the recruitment and retention of high-quality staff. Each section of the document includes a basic description of a particular tool as well as Frequently Asked Questions related to how to best use it in a given set of circumstances or in combination with other flexibilities, unless they are available elsewhere, in which the web link is listed under References for that section. At the end of each section are references with web links that

462

Human Capital Policy Division (HC-11) | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

About Us » Organization » Policy, Accountability, and Technology About Us » Organization » Policy, Accountability, and Technology (HC-10) » Human Capital Policy Division (HC-11) Human Capital Policy Division (HC-11) Mission Statement This division serves as the HCM policy arm for the Department. It supports program objectives and missions of all DOE components by developing HCM-related policies and strategies and supplies advice and guidance across the Department. Functions Provide a full range of staff support to the Chief Human Capital Officer including support required for internal and external responsibilities. Develop and revise the agency human capital management strategy in support of the overall departmental strategic plan. Seek out, influence and translate legislative and regulatory direction into Departmental strategies, policies and programs to address

463

CANCELLED: Mechanism of Human Responses to Ventilation Rates and Air  

NLE Websites -- All DOE Office Websites (Extended Search)

CANCELLED: Mechanism of Human Responses to Ventilation Rates and Air CANCELLED: Mechanism of Human Responses to Ventilation Rates and Air Temperature Speaker(s): Henry Willem Date: July 2, 2010 - 12:00pm Location: 90-3122 Seminar Host/Point of Contact: Max Sherman (THIS SEMINAR TO BE RESCHEDULED.) Sustainability of the built-environment must be achieved in parallel with the sustenance of occupants' health and comfort. Actions to conserve energy and resources require much forethought and careful consideration due to possible consequences on the human aspects. Thus, many extensive works in the recent decades have focused on identifying the associations between indoor environment and human responses. Results have shown moderate to strong implications of thermal and indoor air quality factors on the prevalence and intensity of sick

464

Pantexans volunteer to help Habitat for Humanity | National Nuclear  

National Nuclear Security Administration (NNSA)

Pantexans volunteer to help Habitat for Humanity | National Nuclear Pantexans volunteer to help Habitat for Humanity | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > Pantexans volunteer to help Habitat for Humanity Pantexans volunteer to help Habitat for Humanity Posted By Office of Public Affairs Guy painter Girl painter A number of Pantexans volunteered Friday, March 30, to help renovate two

465

Making the Case for Investments in Human Effectiveness  

Science Conference Proceedings (OSTI)

Investments to enhance human effectiveness in complex systems are rife with several types of uncertainties, intangible benefits, multiple stakeholders, and inherent unpredictability.ďľ ďľ These characteristics make cost/benefit analyses for such systems ...

William B. Rouse; Kenneth R. Boff

1999-12-01T23:59:59.000Z

466

Fundamental patterns of bilateral muscle activity in human locomotion  

Science Conference Proceedings (OSTI)

human locomotion, not much is known about the way in which the central ..... combination of just five factors with a mean square error of only 1.9%. EMG signals ...

467

Making the Climate a Part of the Human World  

Science Conference Proceedings (OSTI)

Doubts about the scientific evidence for anthropogenic climate change persist among the general public, particularly in North America, despite overwhelming consensus in the scientific community about the human influence on the climate system. The public ...

Simon D. Donner

2011-10-01T23:59:59.000Z

468

Hand-Held Analyzer Quickly Detects Buried Human Remains  

A lightweight hand-held analyzer invented by ORNL researchers uses visual andauditory cues to quickly alert investigators to the presence of buried human remains.The Lightweight Analyzer for Buried Remains And Decomposition Odor Recognition(LABRADOR) ...

469

A Hybrid Fuzzy Approach for Human Eye Gaze Pattern Recognition  

Science Conference Proceedings (OSTI)

Face perception and text reading are two of the most developed visual perceptual skills in humans. Understanding which features in the respective visual patterns make them differ from each other is very important for us to investigate the correlation ...

Dingyun Zhu; B. Sumudu Mendis; Tom Gedeon; Akshay Asthana; Roland Goecke

2009-07-01T23:59:59.000Z

470

A metabolic profiling approach to human disorders of energy metabolism  

E-Print Network (OSTI)

The integrated network of biochemical reactions known collectively as metabolism is essential for life, and dysfunction in parts of this network causes human disease - both rare, inherited disorders and common diseases ...

Shaham, Oded

2009-01-01T23:59:59.000Z

471

Double dissociation of dopamine genes and timing in humans  

Science Conference Proceedings (OSTI)

A number of lines of evidence implicate dopamine in timing [Rammsayer, T. H. Neuropharmacological approaches to human timing. In S. Grondin (Ed.), Psychology of time (pp. 295-320). Bingley, UK: Emerald, 2008; Meck, W. H. Neuropharmacology of timing ...

Martin Wiener; Falk W. Lohoff; H. Branch Coslett

2011-10-01T23:59:59.000Z

472

[HUGE]: universal architecture for statistically based HUman GEsturing  

Science Conference Proceedings (OSTI)

We introduce a universal architecture for statistically based HUman GEsturing (HUGE) system, for producing and using statistical models for facial gestures based on any kind of inducement. As inducement we consider any kind of signal that occurs in parallel ...

Karlo Smid; Goranka Zoric; Igor S. Pandzic

2006-08-01T23:59:59.000Z

473

Error weighted classifier combination for multi-modal human identification  

E-Print Network (OSTI)

In this paper we describe a technique of classifier combination used in a human identification system. The system integrates all available features from multi-modal sources within a Bayesian framework. The framework allows ...

Ivanov, Yuri

2005-12-14T23:59:59.000Z

474

Evaluation of human error probabilities for post-initiating events  

E-Print Network (OSTI)

The United States Nuclear Regulatory Commission is responsible for the safe operation of the United States nuclear power plant fleet, and human reliability analysis forms an important portion of the probabilistic risk ...

Dawson, Phillip Eng

2007-01-01T23:59:59.000Z

475

Apparatus and methods for a human de-amplifier system  

SciTech Connect

A human de-amplifier system for interfacing a human operator and a physical object through a physical plant, wherein the physical object has dimensions in the range of 1 micrometer to 1 mm. The human de-amplifier system uses an inner-feedback loop to increases the equivalent damping of the operating system to stabilize the system when it contacts with the environment and reduces the impact of the environment variation by utilizing a high feedback gain, determined by a root locus sketch. Because the stability of the human de-amplifier system of the present invention is greatly enhanced over that of the prior art, the de-amplifier system is able to manipulate the physical object has dimensions in the range of 1 micrometer to 1 mm with high stability and accuracy. The system also has a monitoring device to monitor the motion of the physical object under manipulation.

Kress, Reid L. (Oak Ridge, TN); Jansen, John F. (Knoxville, TN)

2000-01-01T23:59:59.000Z

476

A 2D human body model dressed in eigen clothing  

Science Conference Proceedings (OSTI)

Detection, tracking, segmentation and pose estimation of people in monocular images are widely studied. Two-dimensional models of the human body are extensively used, however, they are typically fairly crude, representing the body either as a rough outline ...

Peng Guan; Oren Freifeld; Michael J. Black

2010-09-01T23:59:59.000Z

477

A human rights approach to the mobile internet  

E-Print Network (OSTI)

2. What is a human rights approach to communication?..............................................4 3. The empowering potential of the mobile internet....................................................6 a. Citizen journalism and peer to peer information sharing.....................................................6 b. Crowdsourcing.............................................................................................................7

Lisa Horner

2011-01-01T23:59:59.000Z

478

Does HR add value? : diverse perspectives on human capital management  

E-Print Network (OSTI)

The human resources (HR) function has evolved significantly over the past several decades. It has grown in maturity and influence while simultaneously enduring great criticism from employees and managers. Meanwhile, ...

Eckman, Jeffrey M

2006-01-01T23:59:59.000Z

479

Structural studies of the human polymeric immunoglobulin receptor  

E-Print Network (OSTI)

The human polymeric immunoglobulin receptor, pIgR, is a glycosylated type I transmembrane protein expressed on the basolateral surface of secretory epithelial cells. pIgR plays a key role in mucosal immunity and, together ...

Hamburger, Agnes Eva, 1976-

2005-01-01T23:59:59.000Z

480

Essays on matching, marriage and human capital accumulation  

E-Print Network (OSTI)

This thesis explores the link between human capital accumulation and the functioning of marriage markets. The first chapter studies the effect of marriage market conditions on pre-marital investment. After showing how a ...

Lafortune, Jeanne

2008-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

An empirical framework to control human attention by robot  

Science Conference Proceedings (OSTI)

Human attention control simply means that the shifting of one's attention from one direction to another. To shift someone's attention, gaining attention and meeting gaze are two most important pre-requisites. If a person would like to communicate with ...

Mohammed Moshiul Hoque; Tomami Onuki; Emi Tsuburaya; Yoshinori Kobayashi; Yoshinori Kuno; Takayuki Sato; Sachiko Kodama

2010-11-01T23:59:59.000Z

482

Human capital, institutions, and incentives : micro and macro perspectives  

E-Print Network (OSTI)

This dissertation consists of four essays on human capital, institutions, and incentives. In the first essay, I investigate the effects of voucher-school competition on educational outcomes in Chile. I present a theoretical ...

Gallego, Francisco A

2006-01-01T23:59:59.000Z

483

Essays on Human Capital Mobility and Asset Pricing  

E-Print Network (OSTI)

associated to capital intensity. This finding suggests that? B . B (2.12b) The intensity of physical capital K i in the? i ). The intensity of general human capital input is given

Donangelo, Andres Francisco

2011-01-01T23:59:59.000Z

484

CAPITAL STRUCTURE, LIQUIDITY AND TRANSFERABLE HUMAN CAPITAL IN COMPETITIVE EQUILIBRIUM  

E-Print Network (OSTI)

This paper analyzes how human capital and economic uncertainty affect capital structure and managerial compensation. We model a competitive industry where wealth constrained managers provide human capital that can be transferred across firms, and where equityholders give managers access to the physical assets of the firm. Equityholders and managers bargain for the firm’s stochastic free cash flows. We show that the level of net debt acts as a tool to attract and retain human capital. Negative net debt occurs in volatile and human capital intensive industries. Cash holdings (or unused lines of credit) in booms serve as a costly hedge against liquidity shocks in recession. The cost of holding cash is internalized by managers, unlike the cost associated with raising cash in recession through a dilutive equity issue. We obtain simple expressions for the equilibrium payout rate and the managerial compensation rate and we show how, in recessions, they are influenced by each party’s outside option.

Bart M. Lambrecht; Grzegorz Pawlina

2009-01-01T23:59:59.000Z

485

The future of game Al : learning to use human tactics  

E-Print Network (OSTI)

Many video games require artificial players that can act as replacements for human players. With today's constant increases in the complexity of games and the prevalence of user-created content, creating an Al that is ...

Dowgun, Neil M

2009-01-01T23:59:59.000Z

486

Ensemble : fluency and embodiment for robots acting with humans  

E-Print Network (OSTI)

This thesis is concerned with the notion of fluency in human-robot interaction (HRI), exploring cognitive mechanisms for robotic agents that would enable them to overcome the stop-and-go rigidity present in much of HRI to ...

Hoffman, Guy, Ph. D. Massachusetts Institute of Technology

2007-01-01T23:59:59.000Z

487

Pantexans volunteer to help Habitat for Humanity | National Nuclear...  

NLE Websites -- All DOE Office Websites (Extended Search)

March 30, to help renovate two Habitat for Humanity homes in Amarillo, Texas. B&W Pantex provided breakfast and lunch for the volunteers, who were encouraged to bring family...