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Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


1

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic...

2

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Irradiation Effects on Human Cortical Bone Fracture Behavior Irradiation Effects on Human Cortical Bone Fracture Behavior Print Wednesday, 28 July 2010 00:00 Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

3

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

4

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

5

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

6

Irradiation Effects on Human Cortical Bone Fracture Behavior  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Irradiation Effects on Human Cortical Bone Fracture Behavior Print Irradiation Effects on Human Cortical Bone Fracture Behavior Print Human bone is strong but still fallible. To better predict fracturing in bone, researchers need a mechanistic framework to understand the changes taking place on different size scales within bone, as well as the role of sustained irradiation damage. Combining in situ mechanical testing with synchrotron x-ray diffraction imaging and/or tomography, is a popular method of investigating micrometer deformation and fracture behavior in bone. However, the role that irradiation plays in these high-exposure experiments, and how it affects the properties of bone tissue, are not yet fully understood. A team of researchers led by Robert O. Ritchie at the Lawrence Berkeley National Laboratory and the University of California, Berkeley used synchrotron radiation micro-tomography at Advanced Light Source Beamline 8.3.2 to investigate changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that exposure to high levels of irradiation can lead to drastic losses in strength, ductility, and toughness.

7

Mixed-mode fracture of human cortical bone Elizabeth A. Zimmermann a,b  

E-Print Network [OSTI]

Mixed-mode fracture of human cortical bone Elizabeth A. Zimmermann a,b , Maximilien E. Launey Available online 1 July 2009 Keywords: Human cortical bone Mixed-mode fracture Fracture toughness Fracture mechanisms a b s t r a c t Although the mode I (tensile opening) fracture toughness has been the focus

Ritchie, Robert

8

Fracture resistance of human cortical bone across multiple length-scales at physiological strain rates  

E-Print Network [OSTI]

Fracture resistance of human cortical bone across multiple length-scales at physiological strain Accepted 22 March 2014 Available online 13 April 2014 Keywords: Bone Strain rate Fracture toughness Plasticity X-ray diffraction a b s t r a c t While most fracture-mechanics investigations on bone have been

Ritchie, Robert

9

Journal of Biomechanics 38 (2005) 15171525 Fracture in human cortical bone: local fracture criteria and  

E-Print Network [OSTI]

Journal of Biomechanics 38 (2005) 1517­1525 Fracture in human cortical bone: local fracture, Livermore, CA 94550 Accepted 19 July 2004 Abstract Micromechanical models for fracture initiation such micromechanical models have been developed for the fracture of bone. In fact, although the fracture event

Ritchie, Robert O.

10

Aging and Fracture of Human Cortical Bone and Tooth Dentin  

E-Print Network [OSTI]

Mechanistic aspects of fracture and R-curve behavior inof failure of solid biomaterials and bone: `fracture' and `pre- fracture' toughness. Materials Science and Engineering:

Ager III, Joel W.

2008-01-01T23:59:59.000Z

11

How Tough is Human Cortical Bone? In-Situ Measurements on Realistically Short Cracks  

E-Print Network [OSTI]

growth resistance of microcrakcing brittle materials. J. Am.materials (including bone), invariably results in resistance-

Koester, K. J.

2008-01-01T23:59:59.000Z

12

Human cortical sensorimotor network underlying feedback control of vocal pitch  

E-Print Network [OSTI]

Human cortical sensorimotor network underlying feedback control of vocal pitch Edward F. Changa,1 control of pitch using direct cortical recordings. Subjects phonated while a real-time signal processor briefly perturbed their output pitch (speak condition). Subjects later heard the same recordings

Knight, Robert T.

13

Improved explanation of human intelligence using cortical features with second order moments and regression  

Science Journals Connector (OSTI)

Background: Cortical features derived from magnetic resonance imaging (MRI) provide important information to account for human intelligence. Cortical thickness, surface area, sulcal depth, and mean curvature were considered to explain human intelligence. ... Keywords: Cortical features, Cortical thickness, Curvature, Human intelligence, Partial least squares regression, Second order moments, Sulcal depth, Surface area

Hyunjin Park, Jin-Ju Yang, Jongbum Seo, Yu-Yong Choi, Kun-Ho Lee, Jong-Min Lee

2014-04-01T23:59:59.000Z

14

The effect of excitation and preparation pulses on nonslice selective 2D UTE bicomponent analysis of bound and free water in cortical bone at 3T  

SciTech Connect (OSTI)

Purpose: The purpose of this study was to investigate the effect of excitation, fat saturation, long T2 saturation, and adiabatic inversion pulses on ultrashort echo time (UTE) imaging with bicomponent analysis of bound and free water in cortical bone for potential applications in osteoporosis. Methods: Six bovine cortical bones and six human tibial midshaft samples were harvested for this study. Each bone sample was imaged with eight sequences using 2D UTE imaging at 3T with half and hard excitation pulses, without and with fat saturation, long T2 saturation, and adiabatic inversion recovery (IR) preparation pulses. Single- and bicomponent signal models were utilized to calculate the T2{sup *}s and/or relative fractions of short and long T2{sup *}s. Results: For all bone samples UTE T2{sup *} signal decay showed bicomponent behavior. A higher short T2{sup *} fraction was observed on UTE images with hard pulse excitation compared with half pulse excitation (75.6% vs 68.8% in bovine bone, 79.9% vs 73.2% in human bone). Fat saturation pulses slightly reduced the short T2{sup *} fraction relative to regular UTE sequences (5.0% and 2.0% reduction, respectively, with half and hard excitation pulses for bovine bone, 6.3% and 8.2% reduction, respectively, with half and hard excitation pulses for human bone). Long T2 saturation pulses significantly reduced the long T2{sup *} fraction relative to regular UTE sequence (18.9% and 17.2% reduction, respectively, with half and hard excitation pulses for bovine bone, 26.4% and 27.7% reduction, respectively, with half and hard excitation pulses for human bone). With IR-UTE preparation the long T2{sup *} components were significantly reduced relative to regular UTE sequence (75.3% and 66.4% reduction, respectively, with half and hard excitation pulses for bovine bone, 87.7% and 90.3% reduction, respectively, with half and hard excitation pulses for human bone). Conclusions: Bound and free water T2{sup *}s and relative fractions can be assessed using UTE bicomponent analysis. Long T2{sup *} components are affected more by long T2 saturation and IR pulses, and short T2{sup *} components are affected more by fat saturation pulses.

Li, Shihong [Department of Radiology, University of California, San Diego, California 92103-8226 (United States) [Department of Radiology, University of California, San Diego, California 92103-8226 (United States); Department of Radiology, Hua Dong Hospital, Fudan University, Shanghai 200040 (China); Yancheng Medical College, Jiangsu (China); The First People's Hospital of Yancheng City, Jiangsu 224005 (China); Chang, Eric Y.; Chung, Christine B. [VA San Diego Healthcare System, San Diego, California 92161 and Department of Radiology, University of California, San Diego, California 92103-8226 (United States)] [VA San Diego Healthcare System, San Diego, California 92161 and Department of Radiology, University of California, San Diego, California 92103-8226 (United States); Bae, Won C.; Du, Jiang, E-mail: jiangdu@ucsd.edu [Department of Radiology, University of California, San Diego, California 92103-8226 (United States)] [Department of Radiology, University of California, San Diego, California 92103-8226 (United States); Hua, Yanqing [Department of Radiology, Hua Dong Hospital, Fudan University, Shanghai 200040 (China)] [Department of Radiology, Hua Dong Hospital, Fudan University, Shanghai 200040 (China); Zhou, Yi [The First People's Hospital of Yancheng City, Jiangsu 224005 (China)] [The First People's Hospital of Yancheng City, Jiangsu 224005 (China)

2014-02-15T23:59:59.000Z

15

Overexpression of DMP1 accelerates mineralization and alters cortical bone biomechanical properties in vivo  

SciTech Connect (OSTI)

Dentin matrix protein-1 (DMP1) is a key regulator of biomineralization. Here, we examine changes in structural, geometric, and material properties of cortical bone in a transgenic mouse model overexpressing DMP1. Micro-computed tomography and three-point bending were performed on 90 femora of wild type and transgenic mice at 1, 2, 4, and 6 months. Fourier transform infrared imaging was performed at 2 months. We found that the transgenic femurs were longer (p < 0.01), more robust in cross-section (p < 0.05), stronger (p < 0.05), but had less post-yield strain and displacement (p < 0.01), and higher tissue mineral density (p < 0.01) than the wild type femurs at 1 and 2 months. At 2 months, the transgenic femurs also had a higher mineral-to-matrix ratio (p < 0.05) and lower carbonate substitution (p < 0.05) compared to wild type femurs. These findings indicate that increased mineralization caused by overexpressing DMP1 led to increased structural cortical bone properties associated with decreased ductility during the early post-natal period.

Bhatia A.; Miller L.; Albazza, M.; Espinoza Orias, A.A.; Inoue, N.; Acerbo, A.; George, A.; Sumner, D.R.

2011-09-29T23:59:59.000Z

16

Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells  

Science Journals Connector (OSTI)

Summary Human pluripotent stem cells are a powerful tool for modeling brain development and disease. The human cortex is composed of two major neuronal populations: projection neurons and local interneurons. Cortical interneurons comprise a diverse class of cell types expressing the neurotransmitter GABA. Dysfunction of cortical interneurons has been implicated in neuropsychiatric diseases, including schizophrenia, autism, and epilepsy. Here, we demonstrate the highly efficient derivation of human cortical interneurons in an NKX2.1::GFP human embryonic stem cell reporter line. Manipulating the timing of SHH activation yields three distinct GFP+ populations with specific transcriptional profiles, neurotransmitter phenotypes, and migratory behaviors. Further differentiation in a murine cortical environment yields parvalbumin- and somatostatin-expressing neurons that exhibit synaptic inputs and electrophysiological properties of cortical interneurons. Our study defines the signals sufficient for modeling human ventral forebrain development in vitro and lays the foundation for studying cortical interneuron involvement in human disease pathology.

Asif M. Maroof; Sotirios Keros; Jennifer A. Tyson; Shui-Wang Ying; Yosif M. Ganat; Florian T. Merkle; Becky Liu; Adam Goulburn; Edouard G. Stanley; Andrew G. Elefanty; Hans Ruedi Widmer; Kevin Eggan; Peter A. Goldstein; Stewart A. Anderson; Lorenz Studer

2013-01-01T23:59:59.000Z

17

Systems/Circuits Cortical Pitch Regions in Humans Respond Primarily to  

E-Print Network [OSTI]

Systems/Circuits Cortical Pitch Regions in Humans Respond Primarily to Resolved Harmonics and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Pitch of pitch perception havedifferentiatedbetweentemporalandspectralcues

Kanwisher, Nancy

18

A representation of changing heading direction in human cortical areas pVIP and CSv  

E-Print Network [OSTI]

Running title: Changing heading direction in the human brain Keywords: egomotion; f1 A representation of changing heading direction in human cortical in the environment, we continually change direction. Much work has examined how the brain

Royal Holloway, University of London

19

Cortical representations of pitch in monkeys and humans Daniel Bendor and Xiaoqin Wang  

E-Print Network [OSTI]

Cortical representations of pitch in monkeys and humans Daniel Bendor and Xiaoqin Wang Pitch acoustic environment. How pitch is represented in the cerebral cortex has for a long time remained-primary region of auditory cortex in primates that contains a cortical representation of pitch. Addresses

Wang, Xiaoqin

20

Structural Analysis of Human and Bovine Bone for Development of Synthetic Materials  

E-Print Network [OSTI]

bones, as well as mimicking nature by developing a synthetic material to repair bones. Experimentally, bovine bone, tumor-free human bone, and cancerous human bone were studied via the small scale mechanical loading test. Failure analysis was conducted...

Jang, Eunhwa

2012-10-19T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Aging and Fracture of Human Cortical Bone and Tooth Dentin  

E-Print Network [OSTI]

in both biological materials, resistance to fracture arisesof fracture resistance in these biological materials, asresistance path along these interfaces through the material.

Ager III, Joel W.

2008-01-01T23:59:59.000Z

22

Accounting for beta-particle energy loss to cortical bone via paired-image radiation transport (PIRT)  

SciTech Connect (OSTI)

Current methods of skeletal dose assessment in both medical physics (radionuclide therapy) and health physics (dose reconstruction and risk assessment) rely heavily on a single set of bone and marrow cavity chord-length distributions in which particle energy deposition is tracked within an infinite extent of trabecular spongiosa, with no allowance for particle escape to cortical bone. In the present study, we introduce a paired-image radiation transport (PIRT) model which provides a more realistic three-dimensional (3D) geometry for particle transport in the skeletal site at both microscopic and macroscopic levels of its histology. Ex vivo CT scans were acquired of the pelvis, cranial cap, and individual ribs excised from a 66-year male cadaver (BMI of 22.7 kg m{sup -2}). For the three skeletal sites, regions of trabecular spongiosa and cortical bone were identified and segmented. Physical sections of interior spongiosa were taken and subjected to microCT imaging. Voxels within the resulting microCT images were then segmented and labeled as regions of bone trabeculae, endosteum, active marrow, and inactive marrow through application of image processing algorithms. The PIRT methodology was then implemented within the EGSNRC radiation transport code whereby electrons of various initial energies are simultaneously tracked within both the ex vivo CT macroimage and the CT microimage of the skeletal site. At initial electron energies greater than 50-200 keV, a divergence in absorbed fractions to active marrow are noted between PIRT model simulations and those estimated under existing techniques of infinite spongiosa transport. Calculations of radionuclide S values under both methodologies imply that current chord-based models may overestimate the absorbed dose to active bone marrow in these skeletal sites by 0% to 27% for low-energy beta emitters ({sup 33}P, {sup 169}Er, and {sup 177}Lu), by {approx}4% to 49% for intermediate-energy beta emitters ({sup 153}Sm, {sup 186}Re, and {sup 89}Sr), and by {approx}14% to 76% for high-energy beta emitters ({sup 32}P, {sup 188}Re, and {sup 90}Y). The PIRT methodology allows for detailed modeling of the 3D macrostructure of individual marrow-containing bones within the skeleton thus permitting improved estimates of absorbed fractions and radionuclide S values for intermediate-to-high energy beta emitters.

Shah, Amish P.; Rajon, Didier A.; Patton, Phillip W.; Jokisch, Derek W.; Bolch, Wesley E. [Department of Biomedical Engineering and Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida 32611 (United States); Deparment of Neurosurgery, University of Florida, Gainesville, Florida 32611 (United States); Department of Health Physics, University of Nevada-Las Vegas, Las Vegas, Nevada (United States); Department of Physics and Astronomy, Francis Marion University, Florence, South Carolina 29501-0547 (United States); Department of Biomedical Engineering and Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida 32611 (United States)

2005-05-01T23:59:59.000Z

23

Application of synchrotron radiation computed microtomography for quantification of bone microstructure in human and rat bones  

SciTech Connect (OSTI)

This work aims to evaluate histomorphometric quantification by synchrotron radiation computed microto-mography in bones of human and rat specimens. Bones specimens are classified as normal and pathological (for human samples) and irradiated and non-irradiated samples (for rat ones). Human bones are specimens which were affected by some injury, or not. Rat bones are specimens which were irradiated, simulating radiotherapy procedures, or not. Images were obtained on SYRMEP beamline at the Elettra Synchrotron Laboratory in Trieste, Italy. The system generated 14 {mu}m tomographic images. The quantification of bone structures were performed directly by the 3D rendered images using a home-made software. Resolution yielded was excellent what facilitate quantification of bone microstructures.

Parreiras Nogueira, Liebert; Barroso, Regina Cely; Pereira de Almeida, Andre; Braz, Delson; Almeida, Carlos Eduardo de; Borba de Andrade, Cherley; Tromba, Giuliana [Nuclear Instrumentation Laboratory / COPPE / UFRJ, P.O. Box 68509, 21945-970, Rio de Janeiro (Brazil); Physics Institute / State University of Rio de Janeiro, 20550-900, Rio de Janeiro (Brazil); Nuclear Instrumentation Laboratory / COPPE / UFRJ, P.O. Box 68509, 21945-970, Rio de Janeiro (Brazil); Laboratory of Radiological Sciences / State University of Rio de Janeiro, Rio de Janeiro (Brazil); Sincrotrone Trieste SCpA, Strada Statale S.S. 14 km 163.5, 34012 Basovizza, Trieste (Italy)

2012-05-17T23:59:59.000Z

24

r Human Brain Mapping 32:382396 (2011) r CENTS: Cortical Enhanced Neonatal Tissue  

E-Print Network [OSTI]

r Human Brain Mapping 32:382­396 (2011) r CENTS: Cortical Enhanced Neonatal Tissue Segmentation-quality magnetic resonance (MR) images of neonatal brains is largely ham- pered by their characteristically small head size and insufficient tissue contrast. As a result, subsequent image processing and analysis

Utah, University of

25

The bending and dynamic mechanical properties of cortical bone: the effects of sodium fluoride and the relationship to physical properties  

E-Print Network [OSTI]

Bone is a complex organic composite material. The graphics. interface between the mineral and organic phases of bone is significant both to medicine and to the biokinetics, a field which seeks to create advanced synthetic materials by copying...

McCurdy-Rahn, Megan Calista

1998-01-01T23:59:59.000Z

26

Stability of muscle synergies for voluntary actions after cortical stroke in humans  

E-Print Network [OSTI]

Production of voluntary movements relies critically on the functional integration of several motor cortical areas, such as the primary motor cortex, and the spinal circuitries. Surprisingly, after almost 40 years of research, ...

Bizzi, Emilio

27

Dissociation of human thalamic and cortical SEP gating as revealed by intrathalamic recordings under muscle relaxation  

Science Journals Connector (OSTI)

‘Gating’ refers to a reduction of cortical somatosensory evoked potentials (SEP) under multiple simultaneous afferent inputs. This study used the opportunity for intrathalamic recordings in patients with movement disorders to clarify to what extent cortical SEP gating is preceded by thalamic gating. Recordings were performed in 10 patients, narcotised by intravenous propofol when receiving implantation of a therapeutic deep brain stimulator system. SEP were elicited by an 8.1-Hz median nerve stimulation at twice motor threshold and were recorded simultaneously from both intrathalamic and scalp electrodes before and after the application of the depolarising muscle blocker succinylcholine which eliminated both the background muscular tone and the repetitive muscle twitches caused by the median nerve stimulation. Peripheral compound action potentials recorded at the upper arm remained unchanged after complete muscle relaxation, proving a continuously effective nerve stimulation. In contrast, the primary cortical SEP component (N20) was significantly increased under succinylcholine (+17%). This cortical release from gating was not paralleled, however, by an increased thalamic response; rather, the primary thalamic response (P16) showed a slight (?9%) but highly significant amplitude reduction. As the recordings were performed in narcotised patients, any potentially variable attentional bias on part of the subjects can be excluded as confounding factor when comparing the two experimental conditions with vs. without reafferent somatosensory inflow. Thus, given the high signal-to-noise ratio of intrathalamically recorded SEP, the present study shows a distinct thalamo–cortical dissociation with the primary somatosensory cortex representing the predominant level exhibiting SEP gating.

Fabian Klostermann; René Gobbele; Helmut Buchner; Gabriel Curio

2002-01-01T23:59:59.000Z

28

PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans  

Science Journals Connector (OSTI)

... The ability to maintain adequate nutrient intake is critical for survival. Complex interrelated neuronal circuits have developed in the mammalian brain to regulate many aspects of feeding behaviour ... largely determined by non-homeostatic factors including cognition, emotion and reward, which are primarily processed in corticolimbic and higher cortical brain regions. Although the pleasure of eating is modulated ...

Rachel L. Batterham; Dominic H. ffytche; J. Miranda Rosenthal; Fernando O. Zelaya; Gareth J. Barker; Dominic J. Withers; Steven C. R. Williams

2007-10-14T23:59:59.000Z

29

The petrous portion of the human temporal bone: potential for forensic individuation  

E-Print Network [OSTI]

are threefold: (1) To investigate variability in the shape of the petrous portion of the human temporal bone using two-dimensional morphometric analysis; (2) to evaluate the reliability of the resultant method in forensic identification; and (3) to consider...

Wiersema, Jason Matthew

2009-06-02T23:59:59.000Z

30

Identification of Ror? targets in cultured osteoblasts and in human bone  

SciTech Connect (OSTI)

Highlights: •We examine the gene expression patterns controlled by Ror? in osteoblasts. •Genes involved in extracellular matrix regulation and proliferation are affected. •Ror? mRNA levels increase in aged, human bone biopsies. •Ror? may affect osteoblast activity by modulation of these pathways. -- Abstract: Control of osteoblastic bone formation involves the cumulative action of numerous transcription factors, including both activating and repressive functions that are important during specific stages of differentiation. The nuclear receptor retinoic acid receptor-related orphan receptor ? (Ror?) has been recently shown to suppress the osteogenic phenotype in cultured osteoblasts, and is highly upregulated in bone marrow-derived osteogenic precursors isolated from aged osteoporotic mice, suggesting Ror? is an important regulator of osteoblast function. However the specific gene expression patterns elicited by Ror? are unknown. Using microarray analysis, we identified 281 genes regulated by Ror? in an MC3T3-E1 mouse osteoblast cell model (MC3T3-Ror?-GFP). Pathway analysis revealed alterations in genes involved in MAPK signaling, genes involved in extracellular matrix (ECM) regulation, and cytokine-receptor interactions. Whereas the identified Ror?-regulated ECM genes normally decline during osteoblastic differentiation, they were highly upregulated in this non-mineralizing MC3T3-Ror?-GFP model system, suggesting that Ror? may exert its anti-osteogenic effects through ECM disruption. Consistent with these in vitro findings, the expression of both ROR? and a subset of ROR?-regulated genes were increased in bone biopsies from postmenopausal women (73 ± 7 years old) compared to premenopausal women (30 ± 5 years old), suggesting a role for ROR? in human age-related bone loss. Collectively, these data demonstrate that Ror? regulates known osteogenic pathways, and may represent a novel therapeutic target for age-associated bone loss.

Roforth, Matthew M., E-mail: roforth.matthew@mayo.edu; Khosla, Sundeep, E-mail: khosla.sundeep@mayo.edu; Monroe, David G., E-mail: monroe.david@mayo.edu

2013-11-01T23:59:59.000Z

31

E-Print Network 3.0 - abnormal cortical asymmetry Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

search results for: abnormal cortical asymmetry Page: << < 1 2 3 4 5 > >> 1 Human Brain Mapping 2008 Conference Abstract Number 438 Detection of Local Cortical Asymmetry via...

32

E-Print Network 3.0 - alveolar bone defects Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

de mathmatiques Collection: Mathematics 30 Evaluation of trabecular bone patterns on dental radiographic images: influence of cortical bone. Summary: , G.J., "An investigation...

33

On the effect of x-ray irradiation on the deformation and fracture behavior of human cortical bone  

E-Print Network [OSTI]

the  presence  of  subcritical crack growth.   It involves displayed  subcritical  (stable)  crack  growth  over  the 

Barth, Holly D.

2010-01-01T23:59:59.000Z

34

The significance of crack-resistance curves to the mixed-mode fracture toughness of human cortical bone  

E-Print Network [OSTI]

in the presence of subcritical crack growth. It involvesgrowth (not crack initiation). As a result, stable (subcritical)

Zimmermann, Elizabeth A.

2010-01-01T23:59:59.000Z

35

DESIGN OF FOAM COVERING FOR ROBOTIC ARMS TO ENSURE HUMAN SAFETY Lingqi Zeng and Gary M. Bone  

E-Print Network [OSTI]

DESIGN OF FOAM COVERING FOR ROBOTIC ARMS TO ENSURE HUMAN SAFETY Lingqi Zeng and Gary M. Bone neglected coupling of the human head to the torso and the coupling of the robot arm to its base. The impact and maintain, which limits their applicability. Using foam to cover the robot arm surface is a simple

Bone, Gary

36

DU145 human prostate cancer cells express functional Receptor Activator of NF-B: New insights in the prostate cancer bone metastasis process.  

E-Print Network [OSTI]

1 DU145 human prostate cancer cells express functional Receptor Activator of NF-B: New insights in the prostate cancer bone metastasis process. Mori K.1, 2, * , Le Goff B. 1, 2 , Charrier C. 1, 2 , Battaglia S;40(4):981-90" DOI : 10.1016/j.bone.2006.11.006 #12;2 Abstract Prostate cancer metastases to bone are observed

Boyer, Edmond

37

Modeling cortical circuits.  

SciTech Connect (OSTI)

The neocortex is perhaps the highest region of the human brain, where audio and visual perception takes place along with many important cognitive functions. An important research goal is to describe the mechanisms implemented by the neocortex. There is an apparent regularity in the structure of the neocortex [Brodmann 1909, Mountcastle 1957] which may help simplify this task. The work reported here addresses the problem of how to describe the putative repeated units ('cortical circuits') in a manner that is easily understood and manipulated, with the long-term goal of developing a mathematical and algorithmic description of their function. The approach is to reduce each algorithm to an enhanced perceptron-like structure and describe its computation using difference equations. We organize this algorithmic processing into larger structures based on physiological observations, and implement key modeling concepts in software which runs on parallel computing hardware.

Rohrer, Brandon Robinson; Rothganger, Fredrick H.; Verzi, Stephen J.; Xavier, Patrick Gordon

2010-09-01T23:59:59.000Z

38

E-Print Network 3.0 - ancient human bones Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

, 2971-2977 first published online 3 June 20092762009Proc. R. Soc. B Summary: Shapiro, Reimer C. Dobberstein, ancient DNA in bone? Is amino acid racemization a useful...

39

Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions  

DOE Patents [OSTI]

The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients.

Srivastava, Suresh C. (Setauket, NY); Meinken, George E. (Middle Island, NY); Mausner, Leonard F. (Stony Brook, NY); Atkins, Harold L. (Setauket, NY)

1998-12-29T23:59:59.000Z

40

Method for palliation of pain in human bone cancer using therapeutic tin-117m compositions  

DOE Patents [OSTI]

The invention provides a method for the palliation of bone pain due to cancer by the administration of a unique dosage of a tin-117m (Sn-117m) stannic chelate complex in a pharmaceutically acceptable composition. In addition, the invention provides a method for simultaneous palliation of bone pain and radiotherapy in cancer patients using compositions containing Sn-117m chelates. The invention also provides a method for palliating bone pain in cancer patients using Sn-117m-containing compositions and monitoring patient status by imaging the distribution of the Sn-117m in the patients. Also provided are pharmaceutically acceptable compositions containing Sn-117m chelate complexes for the palliation of bone pain in cancer patients. 5 figs.

Srivastava, S.C.; Meinken, G.E.; Mausner, L.F.; Atkins, H.L.

1998-12-29T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Proliferation and osteoblastic differentiation of human bone marrow-derived stromal cells on akermanite-bioactive ceramics  

Science Journals Connector (OSTI)

In the present study, the effects of a calcium magnesium silicate bioactive ceramic (akermanite) on proliferation and osteoblastic differentiation of human bone marrow stromal cells (hBMSC) have been investigated and compared with the classical ceramic (?-tricalcium phosphate, ?-TCP). Akermanite and ?-TCP disks were seeded with hBMSC and kept in growth medium or osteogenic medium for 10 days. Proliferation and osteoblastic differentiation were evaluated on day 1, 4, 7 and 10. The data from the Alamar Blue assay and lactic acid production assay showed that hBMSC proliferated more significantly on akermanite than on ?-TCP. The analysis of osteoblast-related genes, including alkaline phosphatase (ALP), osteopontin (OPN), bone sialoprotein (BSP) and osteocalcin (OC), indicated that akermanite ceramics enhanced the expression of osteoblast-related genes, but type I collagen (COL I) showed no noticeable difference among akermanite and ?-TCP ceramics. Furthermore, this stimulatory effect was observed not only in osteogenic medium, but also in normal growth medium without osteogenic reagents such as l-ascorbic acid, glycerophosphate and dexamethasone. This result suggests that akermanite can promote osteoblastic differentiation of hBMSC in vitro even without osteogenic reagents, and may be used as a bioactive material for bone regeneration and tissue engineering applications.

Hongli Sun; Chengtie Wu; Kerong Dai; Jiang Chang; Tingting Tang

2006-01-01T23:59:59.000Z

42

Energy-dispersive X-ray microanalysis of the bone mineral content in human trabecular bone: A comparison with ICPES and neutron activation analysis  

Science Journals Connector (OSTI)

To evaluate the accuracy of bone mineral composition determination by electron microprobe analysis (EDX) the measurements have been compared to instrumental neutron activation analysis (INAA) and chemical anal...

K. Åkesson; M. D. Grynpas; R. G. V. Hancock; R. Odselius…

1994-09-01T23:59:59.000Z

43

A new anthropometric phantom for calibrating in vivo measurements of stable lead in the human leg using X-ray fluorescence  

SciTech Connect (OSTI)

A new anthropometric phantom has been developed for calibrating in vivo measurements of stable lead deposited in bone using x-ray fluorescence. The phantom reproduces the shape of the mid shaft of the adult human leg and is fabricated using polyurethanes and calcium carbonate to produce materials that exhibit the same density, energy transmission, and calcium content as cortical bone, bone marrow, and muscle. The phantom includes a removable tibia fabricated using simulants for cortical bone and bone marrow to which a precise amount of stable lead has been added to cortical bone. The formulations used in fabricating the new anthropometric phantom are much more uniform in density and composition than the conventional phantom made from Plexiglas cylinders filled with plaster-of-Paris. The energy spectrum from an x-ray fluorescence measurement of the phantom using a {sup 109}Cd source is indistinguishable from an in vivo x-ray fluorescence measurement of the human leg, demonstrating that the materials used in the phantom exhibit the same radiological properties as human tissue. Likewise, results from x-ray fluorescence measurements of the phantom exhibit the same positional dependency as the human leg and vary by approximately 36% when, for example, the phantom containing 54 ppm of stable lead in the tibia was rotated by only 15 degrees. The detection limit for a 30 min {sup 109}Cd K shell x-ray fluorescence in vivo measurement is approximately 20 ppm determined from a background measurement using the new phantom containing no added lead in the muscle, bone, or bone marrow. The new anthropometric phantom significantly improves in vivo x-ray fluorescence calibration measurements by (1) faithfully reproducing the anatomy of the human leg, (2) having components that exhibit radiological properties similar to that of human tissue, and (3) providing a realistic calibration standard that can be used for in vivo x-ray fluorescence intercomparison measurements.

Spitz, H.; Jenkins, M.; Lodwick, J.; Bornschein, R.

2000-02-01T23:59:59.000Z

44

Phenotypic Characteristics of Cell Lines Derived from Disseminated Cancer Cells in Bone Marrow of Patients with Solid Epithelial Tumors: Establishment of Working Models for Human Micrometastases  

Science Journals Connector (OSTI)

...serum deprivation. Exp. Cell Res., 224: 208-213, 1996. 59 Van der Velde-Zimmermann D., Verdaasdonk M. A., Rademakers L. H., De Weger R. A., Van den Tweel J. G., Jogling P. Fibronectin distribution in human bone marrow stroma: matrix...

Elmar Putz; Klaus Witter; Sonja Offner; Peter Stosiek; Alfred Zippelius; Judith Johnson; Robert Zahn; Gert Riethmüller; Klaus Pantel

1999-01-01T23:59:59.000Z

45

Biodegradable synthetic bone composites  

DOE Patents [OSTI]

The invention provides for a biodegradable synthetic bone composition comprising a biodegradable hydrogel polymer scaffold comprising a plurality of hydrolytically unstable linkages, and an inorganic component; such as a biodegradable poly(hydroxyethylmethacrylate)/hydroxyapatite (pHEMA/HA) hydrogel composite possessing mineral content approximately that of human bone.

Liu, Gao; Zhao, Dacheng; Saiz, Eduardo; Tomsia, Antoni P.

2013-01-01T23:59:59.000Z

46

Nonintrusive 3D reconstruction of human bone models to simulate their bio-mechanical response  

Science Journals Connector (OSTI)

3D finite element models representing functional parts of the human skeletal system, have been repeatedly introduced over the last years, to simulate biomechanical response of anatomical characteristics or investigate surgical treatment. The reconstruction ... Keywords: 3D imaging, Bio-mechanical response, Computed tomography, FEM modeling

Tsouknidas Alexander; Lontos Antonis; Savvakis Savvas; Michailidis Nikolaos

2012-06-01T23:59:59.000Z

47

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bioactive Glass Scaffolds for Bone Regeneration Bioactive Glass Scaffolds for Bone Regeneration Print Wednesday, 28 September 2011 00:00 Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

48

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

49

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

50

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

51

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure. For example, bone, cork, and wood are porous biological materials with high specific stiffness (stiffness per unit weight) and specific strength. The outstanding mechanical properties of these materials are attributed to their anisotropic structures, which have optimized strength-to-density and stiffness-to-density ratios. Working at ALS Beamline 8.3.2, researchers from Berkeley Lab and the Imperial College London have created bioactive glass scaffolds that mirror nature's efficient materials. The three-dimensional glass scaffold is as porous as trabecular bone, has a compressive strength comparable to that of cortical bone, and a strength-to-porosity ratio higher than any previously reported scaffolds.

52

The Effects of Obesity on Murine Cortical Bone  

E-Print Network [OSTI]

maximum load. Since subcritical crack growth does occur inextent of the subcritical crack growth, the area fraction (toughening during subcritical crack growth in the single-

Martin, Sophi

2010-01-01T23:59:59.000Z

53

Research Finds Vitamin D Deficiency Affects Bone Quality  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of vitamin D, the "sunshine vitamin," have been previously linked to the health and fracture risk of human bone on the basis of low calcium intake and reduced bone density. The...

54

A Novel Method for the Evaluation of Mechanical Properties of Cancellous Bone in the Rat Distal Femur  

E-Print Network [OSTI]

of the bone remaining intact; these studies will be reviewed in the following sections. 2.3.1 Femoral Neck Testing One testing method that interrogates a region of bone containing both cortical and cancellous bone is the femoral neck test. This method... limitation of this method is that while it is closer to simulating uni-axial compression than the indentation method, there remains tri-axial stress caused by the intact cortical shell. Figure 6: RPC Specimen Selection and Testing Method(14) 10...

Lucas, Matthew W.

2010-01-14T23:59:59.000Z

55

E-Print Network 3.0 - aligning cortical hemispheric Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cortical hemispheric Search Powered by Explorit Topic List Advanced Search Sample search results for: aligning cortical hemispheric Page: << < 1 2 3 4 5 > >> 1 Cortical averaging...

56

Acceleration of bone development and regeneration through the Wnt/?-catenin signaling pathway in mice heterozygously deficient for GSK-3?  

SciTech Connect (OSTI)

Highlights: •The Wnt/?-catenin signaling pathway was activated in GSK-3?{sup +/?} mice. •The cortical and trabecular bone volumes were increased in GSK-3?{sup +/?} mice. •Regeneration of a partial bone defect was accelerated in GSK-3?{sup +/?} mice. -- Abstract: Glycogen synthase kinase (GSK)-3? plays an important role in osteoblastogenesis by regulating the Wnt/?-catenin signaling pathway. Therefore, we investigated whether GSK-3? deficiency affects bone development and regeneration using mice heterozygously deficient for GSK-3? (GSK-3?{sup +/?}). The amounts of ?-catenin, c-Myc, cyclin D1, and runt-related transcription factor-2 (Runx2) in the bone marrow cells of GSK-3?{sup +/?} mice were significantly increased compared with those of wild-type mice, indicating that Wnt/?-catenin signals were enhanced in GSK-3?{sup +/?} mice. Microcomputed tomography of the distal femoral metaphyses demonstrated that the volumes of both the cortical and trabecular bones were increased in GSK-3?{sup +/?} mice compared with those in wild-type mice. Subsequently, to investigate the effect of GSK-3? deficiency on bone regeneration, we established a partial bone defect in the femur and observed new bone at 14 days after surgery. The volume and mineral density of the new bone were significantly higher in GSK-3?{sup +/?} mice than those in wild-type mice. These results suggest that bone formation and regeneration in vivo are accelerated by inhibition of GSK-3?, probably through activation of the Wnt/?-catenin signaling pathway.

Arioka, Masaki [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan) [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan); Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka (Japan); Takahashi-Yanaga, Fumi, E-mail: yanaga@clipharm.med.kyushu-u.ac.jp [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan) [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan); Global Medical Science Education Unit, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan); Sasaki, Masanori [Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka (Japan)] [Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka (Japan); Yoshihara, Tatsuya; Morimoto, Sachio [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan); Takashima, Akihiko [Department of Aging Neurobiology, National Center for Geriatrics and Gerontology, Oobu (Japan)] [Department of Aging Neurobiology, National Center for Geriatrics and Gerontology, Oobu (Japan); Mori, Yoshihide [Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka (Japan)] [Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka (Japan); Sasaguri, Toshiyuki [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan)] [Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka (Japan)

2013-11-01T23:59:59.000Z

57

Mechanical bone strength in the proximal tibia  

E-Print Network [OSTI]

. Hvid I, Jansen J: Mechanical strength of the tibial resection surface in total knee replacement. Eng Med 12:173-176, 1983 9. Hvid I, Jansen J: Cancellous bone strength at the proximal human tibia. Eng Med 13:21-25, 1984 28 10. Hvid I, Jansen J.... Hvid I, Jansen J: Mechanical strength of the tibial resection surface in total knee replacement. Eng Med 12:173-176, 1983 9. Hvid I, Jansen J: Cancellous bone strength at the proximal human tibia. Eng Med 13:21-25, 1984 28 10. Hvid I, Jansen J...

Prommin, Danu

2012-06-07T23:59:59.000Z

58

Cortical specialization for music in preverbal infants  

E-Print Network [OSTI]

-linguistic form (musical tones). Research suggests that infants are able to discriminate music using the very same cues they use in language, namely, tempo (Baruch & Drake, 1997; Drake & Bertrand, 2001; Trehub & Thorpe, 1989), meter (T.R. Bergeson, 2002; Halit... deficits following right hemisphere infarction. Brain, 120(May), 785-794. Halit, H., de Haan, M., & Johnson, M., H. (2003). Cortical specialisation for face processing: face-sensitive event-related potential components in 3- and 12- month...

Fava, Eswen Elizabeth

2009-05-15T23:59:59.000Z

59

E-Print Network 3.0 - apparent trabecular bone Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

trabecular bone density in human... Trabecular ... Source: Gefen, Amit - Department of Biomedical Engineering, Tel Aviv University Collection: Engineering ; Biology and Medicine...

60

E-Print Network 3.0 - alveolar bone cells Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

; Biology and Medicine 4 The safety and efficacy of an injectable bone substitute in dental sockets demonstrated in a human clinical trial Summary: tooth sockets by preventing...

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

Fracture, aging, and disease in bone J.W. Ager III  

E-Print Network [OSTI]

Fracture, aging, and disease in bone J.W. Ager III Materials Sciences Division, Lawrence Berkeley-known increase with age in fracture risk of human bone is essential. This also represents a challenge from materials science and fracture mechanics viewpoints. Bone has a complex, hierarchical structure

Ritchie, Robert

62

Adaptive scapula bone remodeling computational simulation: Relevance to regenerative medicine  

SciTech Connect (OSTI)

Shoulder arthroplasty success has been attributed to many factors including, bone quality, soft tissue balancing, surgeon experience, and implant design. Improved long-term success is primarily limited by glenoid implant loosening. Prosthesis design examines materials and shape and determines whether the design should withstand a lifetime of use. Finite element (FE) analyses have been extensively used to study stresses and strains produced in implants and bone. However, these static analyses only measure a moment in time and not the adaptive response to the altered environment produced by the therapeutic intervention. Computational analyses that integrate remodeling rules predict how bone will respond over time. Recent work has shown that subject-specific two- and three dimensional adaptive bone remodeling models are feasible and valid. Feasibility and validation were achieved computationally, simulating bone remodeling using an intact human scapula, initially resetting the scapular bone material properties to be uniform, numerically simulating sequential loading, and comparing the bone remodeling simulation results to the actual scapula’s material properties. Three-dimensional scapula FE bone model was created using volumetric computed tomography images. Muscle and joint load and boundary conditions were applied based on values reported in the literature. Internal bone remodeling was based on element strain-energy density. Initially, all bone elements were assigned a homogeneous density. All loads were applied for 10 iterations. After every iteration, each bone element’s remodeling stimulus was compared to its corresponding reference stimulus and its material properties modified. The simulation achieved convergence. At the end of the simulation the predicted and actual specimen bone apparent density were plotted and compared. Location of high and low predicted bone density was comparable to the actual specimen. High predicted bone density was greater than actual specimen. Low predicted bone density was lower than actual specimen. Differences were probably due to applied muscle and joint reaction loads, boundary conditions, and values of constants used. Work is underway to study this. Nonetheless, the results demonstrate three dimensional bone remodeling simulation validity and potential. Such adaptive predictions take physiological bone remodeling simulations one step closer to reality. Computational analyses are needed that integrate biological remodeling rules and predict how bone will respond over time. We expect the combination of computational static stress analyses together with adaptive bone remodeling simulations to become effective tools for regenerative medicine research.

Sharma, Gulshan B., E-mail: gbsharma@ucalgary.ca [Emory University, Department of Radiology and Imaging Sciences, Spine and Orthopaedic Center, Atlanta, Georgia 30329 (United States); University of Pittsburgh, Swanson School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213 (United States); University of Calgary, Schulich School of Engineering, Department of Mechanical and Manufacturing Engineering, Calgary, Alberta T2N 1N4 (Canada); Robertson, Douglas D., E-mail: douglas.d.robertson@emory.edu [Emory University, Department of Radiology and Imaging Sciences, Spine and Orthopaedic Center, Atlanta, Georgia 30329 (United States); University of Pittsburgh, Swanson School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213 (United States)

2013-07-01T23:59:59.000Z

63

Bone Canonical WNT/B-Catenin Signaling in Models of Reduced Microgravity  

E-Print Network [OSTI]

BONE CANONICAL WNT/?-CATENIN SIGNALING IN MODELS OF REDUCED MICROGRAVITY A Dissertation by BRANDON RICHARD MACIAS Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... Copyright 2012 Brandon Richard Macias ii ABSTRACT Human exposure to reduced weightbearing results in bone loss. The rate of bone loss during microgravity exposure is similar to that of a post-menopausal women. In fact, the maintenance of bone mass...

Macias, Brandon 1979-

2012-10-25T23:59:59.000Z

64

Human cortical sensorimotor network underlying feedback control of vocal pitch  

Science Journals Connector (OSTI)

...self-produced speech are suppressed (listening > speaking). Self-vocalization...pitch feedback (speaking > listening) (23), a phenomenon called...digital signal-processing device (DSP) to induce real-time pitch...differed between speaking and listening. (High-{gamma...

Edward F. Chang; Caroline A. Niziolek; Robert T. Knight; Srikantan S. Nagarajan; John F. Houde

2013-01-01T23:59:59.000Z

65

RESEARCH ARTICLE Outline of a novel architecture for cortical computation  

E-Print Network [OSTI]

RESEARCH ARTICLE Outline of a novel architecture for cortical computation Kaushik Majumdar Received for cortical computation has been proposed. This architecture is com- posed of computing paths consisting for this type of computation has been the von Neumann architecture where the memory is accessed

Bandyopadhyay, Antar

66

Methods for testing the strength of cancellous bone and tested method effects on cortical bone in the ovariectomized rat  

E-Print Network [OSTI]

(EMF), Energy to the Max Force; (EFF), Energy to Fracture Force, (EMF to EFF), Energy from the maximum force to the fracture force for the OVX and Sham groups. . . 84 Figure 57 "Punch method" compression testing on slices removed from the proximal.../mm) for the OVX and Sham operated groups. 91 Figure 5 15. "Whole slice method" compression testing on slices removed from the proximal portion of the tibia (EMF), Energy to the Max Force; (EFF), Energy to Fracture Force, (EMF to EFF), Energy from the maximum...

Ruhmann, Sean Phillip

2012-06-07T23:59:59.000Z

67

Transatlantic Bone Marrow Transplantation  

Science Journals Connector (OSTI)

The Ontario Cancer Institute/ Princess Margaret Hospital, Bone Marrow Transplant and Leukemia Service, Toronto, Canada, Dr. J. H. Lipton, asked our new HLA-DNA typing laboratory at University Hospital in Olomo...

M. Bencová; J. Benca

1997-01-01T23:59:59.000Z

68

Penetration of piperacillin-tazobactam into cancellous and cortical bone tissues.  

Science Journals Connector (OSTI)

...Scand. J. Infect. Dis. (Suppl.)74:23-33. 4. Fortner, C. L, R. S. Finley, and S. C. Schimpff. 1982. Piperacillin...489-494. 7. Kinzig, M., P. Muth, P. Kujath, J. Ebert, G. Mahr, and F. Sorgel, et al. 1991. Pharmacokinetics...

S J Incavo; P J Ronchetti; J H Choi; H Wu; M Kinzig; F Sörgel

1994-04-01T23:59:59.000Z

69

The harmful effects of late-onset alcohol consumption on cortical bone in aged rats  

E-Print Network [OSTI]

This study looked at the effects of late-onset alcohol consumption for 8 weeks on the aged rat model (15 months old). Thirty 15 month old female Fisher 344 rats were divided into three diet groups: Alcohol (n=9), pair-fed (n=9), and pellet (n=6...

Bowlin, Julie Lee

2012-06-07T23:59:59.000Z

70

Topic 7 Organization of Motor System -Cortical Motor Areas  

E-Print Network [OSTI]

Cartoon, 1986 Electrical stimulation produces movement of contralateral body parts. #12;4 Motor Homunculus previous stimulation technique · Insert electrode into cortical layer V and use electrical stimulation" somatotopic map vs "more complex" map #12;

Sergio, Lauren E.

71

Cortical Activation During Spatiotemporal Processing in the Infant Brain  

E-Print Network [OSTI]

CORTICAL ACTIVATION DURING SPATIOTEMPORAL PROCESSING IN THE INFANT BRAIN A Thesis by JENNIFER RUTH ARMSTRONG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE December 2008 Major Subject: Psychology CORTICAL ACTIVATION DURING SPATIOTEMPORAL PROCESSING IN THE INFANT BRAIN A Thesis by JENNIFER RUTH ARMSTRONG Submitted to the Office of Graduate Studies...

Armstrong, Jennifer R.

2010-01-14T23:59:59.000Z

72

Evaluation of ultrasound transmission velocity and 3-dimensional radiology in different bone types for dental implantology: a comparative ex vivo study  

Science Journals Connector (OSTI)

Objective To evaluate ultrasound transmission velocity (UTV) for assessment of mechanical bone quality, an ex vivo comparison of different bone types measured with UTV, 2-dimensional (2D) histomorphometry and with 3-dimensional (3D) radiology (cone-beam computerized tomography [CBCT], computerized microtomography [?CT]) was conducted. Study Design Clinical cortical, cancellous, and mixed bone (each n = 6) was measured via UTV (m/s), CBCT (white pixel/black pixel ratio [WP/BP]), ?CT (bone volume/total volume [?BV/TV]), and histomorphometry (bone volume/total volume [hBV/TV]). UTV values were correlated with 2D-histomorphometry and 3D-radiologic results. Results For the cortical, cancellous, and mixed bone samples, respectively, UTV values were 1,945.17, 1,266.9,and 1472.2 m/s, WP/BP quotients were 0.96, 0.15, and 0.33, ?BV/TV quotients were 0.94, 0.2, and 0.47, and hBV/TV quotients were 0.96, 0.24 and 0.39. Significant correlations between UTV and the other methods were seen (P < .0001). Conclusions Similar to the other methods, UTV is able to discriminate between different bone types ex vivo.

Peer W. Kämmerer; Vinay V. Kumar; Dan Brüllmann; Hermann Götz; Peter H. Kann; Bilal Al-Nawas; Marcus O. Klein

2013-01-01T23:59:59.000Z

73

Epidural cortical stimulation enhances motor function after sensorimotor cortical infarcts in rats  

Science Journals Connector (OSTI)

This study examined whether epidurally delivered cortical electrical stimulation (CS) improves the efficacy of motor rehabilitative training and alters neuronal density and/or cell proliferation in perilesion cortex following ischemic sensorimotor cortex (SMC) lesions. Adult rats were pre-trained on a skilled reaching task and then received partial unilateral SMC lesions and implantation of electrodes over the remaining SMC. Ten to fourteen days later, rats received daily reach training concurrent with anodal or cathodal 100 Hz CS or no stimulation (NoCS) for 18 days. To label newly generated cells, bromodeoxyuridine (BrdU; 50 mg/kg) was administered every third day of training. Both anodal and cathodal CS robustly enhanced reaching performance compared to NoCS controls. Neuronal density in the perilesion cortex was significantly increased in the cathodal CS group compared to the NoCS group. There were no significant group differences in BrdU-labeled cell density in ipsilesional cortex. Staining with Fluoro-Jade-B indicated that neurons continue to degenerate near the infarct at the time when cortical stimulation and rehabilitation were initiated. These data indicate that epidurally delivered CS greatly improves the efficacy of rehabilitative reach training following SMC damage and raise the possibility that cathodal CS may influence neuronal survival in perilesion cortex.

DeAnna L. Adkins; Peter Campos; David Quach; Mark Borromeo; Kellan Schallert; Theresa A. Jones

2006-01-01T23:59:59.000Z

74

Bone marrow endothelium-targeted therapeutics for metastatic breast cancer  

Science Journals Connector (OSTI)

Abstract Effective treatment of cancer metastasis to the bone relies on bone marrow drug accumulation. The surface proteins in the bone marrow vascular endothelium provide docking sites for targeted drug delivery. We have developed a thioaptamer that specifically binds to E-selectin that is overexpressed in the vasculature of tumor and inflammatory tissues. In this study, we tested targeted delivery of therapeutic siRNA loaded in the E-selectin thioaptamer-conjugated multistage vector (ESTA-MSV) drug carrier to bone marrow for the treatment of breast cancer bone metastasis. We evaluated tumor type- and tumor growth stage-dependent targeting in mice bearing metastatic breast cancer in the bone, and carried out studies to identify factors that determine targeting efficiency. In a subsequent study, we delivered siRNA to knock down expression of the human STAT3 gene in murine xenograft models of human MDA-MB-231 breast tumor, and assessed therapeutic efficacy. Our studies revealed that the CD31+E-selectin+ population accounted for 20.8%, 26.4% and 29.9% of total endothelial cells respectively inside the femur of mice bearing early, middle and late stage metastatic MDA-MB-231 tumors. In comparison, the double positive cells remained at a basal level in mice with early stage MCF-7 tumors, and jumped to 23.9% and 28.2% when tumor growth progressed to middle and late stages. Accumulation of ESTA-MSV inside the bone marrow correlated with the E-selectin expression pattern. There was up to 5-fold enrichment of the targeted MSV in the bone marrow of mice bearing early or late stage MDA-MB-231 tumors and of mice with late stage, but not early stage, MCF-7 tumors. Targeted delivery of STAT3 siRNA in ESTA-MSV resulted in knockdown of STAT3 expression in 48.7% of cancer cells inside the bone marrow. Weekly systemic administration of ESTA-MSV/STAT3 siRNA significantly extended survival of mice with MDA-MB-231 bone metastasis. In conclusion, targeting the overexpressed E-selectin provides an effective approach for tissue-specific drug delivery to the bone marrow. Tumor growth in the bone can be effectively inhibited by blockage of the STAT3 signaling.

Junhua Mai; Yi Huang; Chaofeng Mu; Guodong Zhang; Rong Xu; Xiaojing Guo; Xiaojun Xia; David E. Volk; Ganesh L. Lokesh; Varatharasa Thiviyanathan; David G. Gorenstein; Xuewu Liu; Mauro Ferrari; Haifa Shen

2014-01-01T23:59:59.000Z

75

E-Print Network 3.0 - affecting human performance Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Computer Technologies and Information Sciences 5 Multisensor System for Safer Human-Robot Interaction Yucong Lu, Lingqi Zeng and Gary M. Bone* Summary: to perform human...

76

E-Print Network 3.0 - age-related cortical brain Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

brain Search Powered by Explorit Topic List Advanced Search Sample search results for: age-related cortical brain Page: << < 1 2 3 4 5 > >> 1 Mapping Cortical Thickness and Gray...

77

Rescue from apoptosis in early (CD34-selected) versus late (non-CD34-selected) human hematopoietic cells by very late antigen 4- and vascular cell adhesion molecule (VCAM) 1-dependent adhesion to bone marrow stromal cells  

Science Journals Connector (OSTI)

...transplanted hematopoietic cells by bone marrow. Proc. NatI. Aced. Sci. USA, 85: 3180-3183, 1988. 18. Joling, P., Rademakers, L H. P. M., Verdaasdonk, M. A. M., Zimmermann, D., Spienngs, D. C. J., Werner, N., Werner, R. A...

MW Wang; U Consoli; CM Lane; A Durett; MJ Lauppe; R Champlin; M Andreeff; AB Deisseroth

1998-02-01T23:59:59.000Z

78

Using High Angular Resolution Diffusion Imaging Data to Discriminate Cortical Regions  

E-Print Network [OSTI]

of the signal variation as non­random and reproducible is the critical condition for successful cortical

Sereno, Martin

79

Case 33-2014 — A 60-Year-Old Man with Bone Pain  

Science Journals Connector (OSTI)

...-microglobulin, results of liver-function tests and serum protein electrophoresis, and the 24-hour urinary histamine level. Testing for antibodies to human immunodeficiency virus types 1 and 2 was reportedly negative, as was FISH analysis for the BCR-ABL rearrangement and testing of peripheral-blood leukocytes... A 60-year-old man was seen in the outpatient cancer center because of bone pain that had lasted for 2 months and the presence of lytic bone lesions on imaging studies. Biopsy specimens of bone marrow and bone lesions showed increased mast cells. A diagnostic procedure was performed.

Choy E.Attar E.C.Oh K.S.Huang A.J.Kerr D.A.

2014-10-23T23:59:59.000Z

80

Simulating sensorimotor systems with cortical topology  

E-Print Network [OSTI]

Configuration Space . . . Figure 12. Degeneracy. . Figure 13. Neurobot I. Figure 14. Forward Kinematic Equations for a Two Degree-of-Freedom Robot Arm. . 27 . . . . , 28 . . . . . . . 29 . . . . . 30 Figure 15. Neural Net Mapping of the Four Dimensional... common human capability which occurs immediately, without relying upon neural adaption. 2. 1. 1. 2. Selective Attention Selective attention is another aspect of a type III network. Grossberg and Fukushima have both developed recurrent layered neural...

Saxon, James Bennett

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

E-Print Network 3.0 - alveolar bone formation Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sutures to Deciduous Dentition in Nonhuman Primates K... .D., E.R. Dumont, Ph.D., T.D. Smith, Ph.D. Objective: The relationship of the human premaxillary bone Source: Dumont,...

82

Fracture, aging and disease in bone  

E-Print Network [OSTI]

separate during bone fracture. Nature Materials 4, 612 (on nonagenarians with hip fractures? Injury 30, 169 (1999).bone mass as predictors of fracture in a prospective study.

Ager, J.W.; Balooch, G.; Ritchie, R.O.

2006-01-01T23:59:59.000Z

83

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Bioactive Glass Scaffolds for Bone Regeneration Print Wednesday, 28 September 2011 00:00 Natural materials are renowned for their...

84

Chronic in vivo imaging of dendritic plasticity and functional remapping after cortical stroke  

E-Print Network [OSTI]

contralateral hemisphere after stroke, has been conducted inaffected areas after stroke. This hypothesis was initiallyremapping after cortical stroke. Cereb Cortex. 2012 Apr 11;

Johnston, David

2012-01-01T23:59:59.000Z

85

E-Print Network 3.0 - amygdala-orbitofrontal cortical functional...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Complementary... indicates that this cortical region is engaged in multiple aspects of brain function, as reviewed... College of Medicine. His group studies the functional...

86

E-Print Network 3.0 - abnormal cortical processing Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Northwestern University Collection: Biology and Medicine 29 DevelopmentPlasticityRepair Thick Visual Cortex in the Early Blind Summary: measure for detecting cortical...

87

Bone Surface and Whole Bone as Biomarkers for Acute Fluoride Exposure  

Science Journals Connector (OSTI)

......whole bone Fas a function oftime after the F doseswere tested for statistically significant differences by the Kruskal-Wallis test and Dunn's multiple comparison test. The correlation between bone surface and whole bone F concentrations......

Marília Afonso Rabelo Buzalaf; Elide Escolástico Caroselli; Juliane Guimarães de Carvalho; Rodrigo Cardoso de Oliveira; Vanessa Eid da Silva Cardoso; Gary Milton Whitford

2005-01-01T23:59:59.000Z

88

Reconstructing human evolution: Achievements, challenges, and opportunities  

Science Journals Connector (OSTI)

...occipital bone. Mandibular and dental features include a retromolar...incidences of some nonmetrical dental traits, and thinner...F ( 2000 ) Using diagnostic radiology in human evolutionary studies...Nondestructive imaging of hominoid dental microstructure using phase contrast...

Bernard Wood

2010-01-01T23:59:59.000Z

89

On the role of inhibition in cortical plasticity: a computational study \\Lambda Lubica Benuskov'a  

E-Print Network [OSTI]

, experience, cortical plasticity, dynamic synaptic modification threshold, inhibition, non­specificity 1On the role of inhibition in cortical plasticity: a computational study \\Lambda Lubica BeŸnuŸskov'a Department of Computer Science and Engineering Slovak Technical University, 81219 Bratislava, Slovakia

Benuskova, Luba

90

Reply: Lithium and Increased Cortical Gray Matter--More Tissue or More Water?  

E-Print Network [OSTI]

Reply: Lithium and Increased Cortical Gray Matter--More Tissue or More Water? To the Editor: W e cortices, in lithium-treated patients with bipolar disorder, relative to healthy control subjects (1). Dr patients. Although lithium's effects on body water homeostasis (2) are important to consider, the absence

Thompson, Paul

91

pH dependence and compartmentalization of zinc transported across plasma membrane of rat cortical neurons  

E-Print Network [OSTI]

pH dependence and compartmentalization of zinc transported across plasma membrane of rat corticalH dependence and compartmental- ization of zinc transported across plasma membrane of rat cortical neurons. Am; ion transport; transition elements; primary culture IT IS KNOWN THAT Zn2 can enter neurons by two

92

Sulcus detection in planar projections of cortical surfaces Mutawarra Hussain and Ela Claridge  

E-Print Network [OSTI]

projection, the cortical part of the brain volume is transformed into a stack of 2D slices, each representing a pixel-deep hemispherical shell. In this representation, cortex forms a nearly-planar surface, while require substantial computing power. This paper describes a method for finding the cortical position

Claridge, Ela

93

Supplementary Figure 1 Tract trajectory estimates and cortical projection zones for different tractography algorithms.  

E-Print Network [OSTI]

(SLF; purple) and right Arcuate Fasciculus (gold) in a candidate connectome generated using showing the cortical projection zones of the SLF. The color overlay depicts the density of fiber connectome was generated using probabilistic tractography. Right panel, SLF cortical projection zones. Nature

Cai, Long

94

A Rho-signaling pathway mediates cortical granule translocation in the sea urchin oocyte  

E-Print Network [OSTI]

´mica, Universidad de Guanajuato, Col. Noria Alta, Guanajuato, Gto 3600, A.P. 187, Mexico b Department of Molecular-mediated process. We tested the hypothesis that these cortical granule dynamics were regulated by Rho, a GTPase of the cortical granules in the cortex, as well as their fusion at fertilization, are Rho-independent processes

Wessel, Gary M.

95

E-Print Network 3.0 - anti-fya seraclone human Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

presented. Sphere-based geometric models... are used for the human and robot due to the efficiency of the distance computation. The collision avoidance Source: Bone, Gary -...

96

E-Print Network 3.0 - ancient human dna Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

validating ampli- fication of human DNA. Here, we take advantage of two large ancient... Shapiro, Reimer C. Dobberstein, ancient DNA in bone? Is amino acid racemization a useful...

97

Positive modulator of bone morphogenic protein-2  

DOE Patents [OSTI]

Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.

Zamora, Paul O. (Gaithersburg, MD); Pena, Louis A. (Poquott, NY); Lin, Xinhua (Plainview, NY); Takahashi, Kazuyuki (Germantown, MD)

2009-01-27T23:59:59.000Z

98

Treatment for Myeloma Bone Disease  

Science Journals Connector (OSTI)

...in the use of bone-seeking radiopharmaceuticals make these attractive therapeutic...26 Abildgaard N, Bentzen SM, Nielsen JL, Heickendorff...patients, correlation with TC-99M-sestaMIBI scintigraphy...Palermo S. Samarium-153 Sm-EDTMP and zoledronic acid...

Howard S. Yeh and James R. Berenson

2006-10-15T23:59:59.000Z

99

Examining Associations between Emotional Facial Expressions, Relative Left Frontal Cortical Activity, and Task Persistence  

E-Print Network [OSTI]

in degrees of approach motivation would influence relative left frontal cortical activity measured with electroencephalography (EEG) alpha power and task persistence measured with time working on insolvable geometric puzzles. Furthermore, relative left...

Price, Thomas

2012-10-19T23:59:59.000Z

100

Digital electronic bone growth stimulator  

DOE Patents [OSTI]

The present invention relates to the electrical treatment of biological tissue. In particular, the present invention discloses a device that produces discrete electrical pulse trains for treating osteoporosis and accelerating bone growth. According to its major aspects and broadly stated, the present invention consists of an electrical circuit configuration capable of generating Bassett-type waveforms shown with alternative signals provide for the treatment of either fractured bones or osteoporosis. The signal generator comprises a quartz clock, an oscillator circuit, a binary divider chain, and a plurality of simple, digital logic gates. Signals are delivered efficiently, with little or no distortion, and uniformly distributed throughout the area of injury. Perferably, power is furnished by widely available and inexpensive radio batteries, needing replacement only once in several days. The present invention can be affixed to a medical cast without a great increase in either weight or bulk. Also, the disclosed stimulator can be used to treat osteoporosis or to strengthen a healing bone after the cast has been removed by attaching the device to the patient`s skin or clothing.

Kronberg, J.W.

1993-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

A reaction-diffusion model of the human brain development  

Science Journals Connector (OSTI)

The anatomical variability of the human brain folds remains an unclear and challenging issue. Several hypotheses coexist for explaining the rapid development of cortical sulci and it is clear that understanding their variability would improve the comparison ... Keywords: brain development, folding, reaction-diffusion equations

Julien Lefèvre; Jean-François Mangin

2010-04-01T23:59:59.000Z

102

On Smoothing Surfaces in Voxel Based Finite Element Analysis of Trabecular Bone  

E-Print Network [OSTI]

-)finite element analysis based on three-dimen- sional computed tomography (CT) data of human bone takes place finite element (FE) analysis. The approach based on the FE analysis leads to linear systems of equations analysis the computational domain is composed of a multitude of tiny cubes, so-called voxels

Frey, Pascal

103

Bone Mineral Density in Women with Depression  

Science Journals Connector (OSTI)

...illness and the normal women were individually matched for age, body-mass index, and menstrual status; women with many of the risk factors associated with decreased bone mineral density were excluded; dual-energy x-ray absorptiometry was used to measure bone density at the spine, hip, and radius; and bone... Major depression is a complex disorder reflecting genetic, developmental, and environmental factors. Although its pathophysiology is not clearly understood, depression is associated with hypothalamic dysfunction — specifically, hypercortisolism, the ...

Michelson D.; Stratakis C.; Hill L.

1996-10-17T23:59:59.000Z

104

WRITTEN IN BONE: Bone Biographer's Casebook Douglas Owsley and Karin Bruwelheide  

E-Print Network [OSTI]

afflictions that would have made daily life miserable. In addition to dental disease and gout, his bones were

Mathis, Wayne N.

105

Composite bone substitutes prepared by two methods  

E-Print Network [OSTI]

Hydroxyapatite-polyethylene composites: effect of graftingof braded carbon/PEEK composite compression bone plates,”Koch, “Hydroxyapatite/SiO2 Composites via Freeze Casting for

Lee, Hoe Yun; Lee, Hoe Yun

2012-01-01T23:59:59.000Z

106

Ultrasound-Confirmed Frontal Bone Fracture  

E-Print Network [OSTI]

table--frontal sinus fractures. Facial Plast Surg Clin NorthConfirmed Frontal Bone Fracture Jeremy N. Johnson, DO Danielan isolated comminuted fracture of the left frontal sinus

Johnson, Jeremy N; Crandall, Stephen; Kang, Christopher S

2009-01-01T23:59:59.000Z

107

Bioactive Glass Scaffolds for Bone Regeneration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Bioactive Glass Scaffolds for Bone Regeneration Print Natural materials are renowned for their unique combination of outstanding mechanical properties and exquisite microstructure....

108

Hydroxyapatite-binding peptides for bone growth and inhibition  

DOE Patents [OSTI]

Hydroxyapatite (HA)-binding peptides are selected using combinatorial phage library display. Pseudo-repetitive consensus amino acid sequences possessing periodic hydroxyl side chains in every two or three amino acid sequences are obtained. These sequences resemble the (Gly-Pro-Hyp).sub.x repeat of human type I collagen, a major component of extracellular matrices of natural bone. A consistent presence of basic amino acid residues is also observed. The peptides are synthesized by the solid-phase synthetic method and then used for template-driven HA-mineralization. Microscopy reveal that the peptides template the growth of polycrystalline HA crystals .about.40 nm in size.

Bertozzi, Carolyn R. (Berkeley, CA); Song, Jie (Shrewsbury, MA); Lee, Seung-Wuk (Walnut Creek, CA)

2011-09-20T23:59:59.000Z

109

Integrator or coincidence detector? The role of the cortical neuron revisited  

Science Journals Connector (OSTI)

Neurons can operate in two distinct ways, depending on the duration of the interval over which they effectively summate incoming synaptic potentials. If this interval is of the order of the mean interspike interval or longer, neurons act effectively as temporal integrators and transmit temporal patterns with only low reliability. If, by contrast, the integration interval is short compared to the interspike interval, neurons act essentially as coincidence detectors, relay preferentially synchronized input, and the temporal structure of their output is a direct function of the input pattern. Recently, interest in this distinction has been revived because experimental and theoretical results suggest that synchronous firing of neurons might play an important role for information processing in the cortex. Here, we argue that coincidence detection, rather than temporal integration, might be a prevalent operation mode of cortical neurons. We base our arguments on established biophysical properties of cortical neurons and on particular features of cortical dynamics.

Peter König; Andreas K. Engel; Wolf Singer

1996-01-01T23:59:59.000Z

110

Extraction and analysis of neuron firing signals from deep cortical video microscopy  

SciTech Connect (OSTI)

We introduce a method for extracting and analyzing neuronal activity time signals from video of the cortex of a live animal. The signals correspond to the firing activity of individual cortical neurons. Activity signals are based on the changing fluorescence of calcium indicators in the cells over time. We propose a cell segmentation method that relies on a user-specified center point, from which the signal extraction method proceeds. A stabilization approach is used to reduce tissue motion in the video. The extracted signal is then processed to flatten the baseline and detect action potentials. We show results from applying the method to a cortical video of a live mouse.

Kerekes, Ryan A [ORNL; Blundon, Jay [St. Jude Children's Research Hospital

2014-01-01T23:59:59.000Z

111

Ultrastructure of the cortical epithelium of the rat thymus after in vivo exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)  

Science Journals Connector (OSTI)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is known for inducing cortical atrophy in the rat thymus. The present study was conducted to provide ultrastructural evidence for the cortical epithelium to be a target ...

Eric J. De Waal; Louk H. P. M. Rademakers; Henk-Jan Schuurman…

1993-01-01T23:59:59.000Z

112

Fracture, aging and disease in bone  

E-Print Network [OSTI]

by enhancing the materials resistance to microstructuralgrowth resistance of microcracking brittle materials. J. Am.resistance to fracture of the Page 4 Fracture, Aging and Disease in Bone underlying material.

Ager, J.W.; Balooch, G.; Ritchie, R.O.

2006-01-01T23:59:59.000Z

113

SELF-ORGANIZATION AND NEURONAL AVALANCHES IN NETWORKS OF DISSOCIATED CORTICAL NEURONS  

E-Print Network [OSTI]

networks developing in vitro and chronically coupled to micro-electrode arrays (MEAs) rep- resentSELF-ORGANIZATION AND NEURONAL AVALANCHES IN NETWORKS OF DISSOCIATED CORTICAL NEURONS V. PASQUALE cultured onto micro-electrode arrays exhibit characteristic patterns of electrophysiological activity

Arleo, Angelo

114

Computational subunits of visual cortical neurons revealed by artificial neural networks  

E-Print Network [OSTI]

Computational subunits of visual cortical neurons revealed by artificial neural networks Brian Lau neurons of the cat to spatiotemporal random-bar stimuli and trained artificial neural networks to predict with a simple functional model for complex cells and demonstrate the usefulness of the neural network method

Lau, Brian

115

The Cotton Kinesin-Like Calmodulin-Binding Protein Associates with Cortical Microtubles in Cotton Fibers  

SciTech Connect (OSTI)

Microtubules in interphase plant cells form a cortical array, which is critical for plant cell morphogenesis. Genetic studies imply that the minus end-directed microtubule motor kinesin-like calmodulin-binding protein (KCBP) plays a role in trichome morphogenesis in Arabidopsis. However, it was not clear whether this motor interacted with interphase microtubules. In cotton (Gossypium hirsutum) fibers, cortical microtubules undergo dramatic reorganization during fiber development. In this study, cDNA clones of the cotton KCBP homolog GhKCBP were isolated from a cotton fiber-specific cDNA library. During cotton fiber development from 10 to 21 DPA, the GhKCBP protein level gradually decreases. By immunofluorescence, GhKCBP was detected as puncta along cortical microtubules in fiber cells of different developmental stages. Thus the results provide evidence that GhKCBP plays a role in interphase cell growth likely by interacting with cortical microtubules. In contrast to fibers, in dividing cells of cotton, GhKCBP localized to the nucleus, the microtubule preprophase band, mitotic spindle, and the phragmoplast. Therefore KCBP likely exerts multiple roles in cell division and cell growth in flowering plants.

Preuss, Mary L.; Delmar, Deborah P.; Liu, Bo

2003-05-01T23:59:59.000Z

116

Approach- and Withdrawal-Oriented Responses to Social Rejection: The Role of Asymmetrical Frontal Cortical Activity  

E-Print Network [OSTI]

frontal cortical activity being associated with increased anger. iv NOMENCLATURE EEG Electroencephalography EMG Electromyography v TABLE OF CONTENTS Page ABSTRACT.... Condition assignment was determined randomly. EEG was recorded during the task. When the game was over (approximately four minutes later), participants completed a questionnaire assessing their perceived level of anger 1 , enjoyment, and the four...

Peterson, Carly Kathryn

2011-02-22T23:59:59.000Z

117

Detecting Cortical Surface Regions in Structural MR Data Biswajit Bose1,  

E-Print Network [OSTI]

Detecting Cortical Surface Regions in Structural MR Data Biswajit Bose1, , John Fisher1 , Bruce on a challenging ex-vivo structural MR dataset for detection of Brodmann area 17. 1. Introduction Detection-resolution MR volume. Figure 1 shows a slice through structural MR data of the primary vi- sual cortex, where BA

Fisher III, John

118

From the decoding of cortical activities to the control of a JACO robotic arm  

E-Print Network [OSTI]

From the decoding of cortical activities to the control of a JACO robotic arm: a whole processing in the cortex of a monkey and replicates the associated movements on a JACO robotic arm by Kinova. We developed the data, compute the position of the robotic finger and send this position to the robotic arm. More pre

Paris-Sud XI, Université de

119

Efficient Representation of Cortical Convolutions for the Analysis of Brain Surface Topology  

E-Print Network [OSTI]

Efficient Representation of Cortical Convolutions for the Analysis of Brain Surface Topology Peter of the brain in MR and CT clearly con- veying the whole surface topology. For the comparison of the provided with direct volume rendering. Considering brain information exclusively, and ensuring a standardized

Blanz, Volker

120

Cortical Enhanced Tissue Segmentation of Neonatal Brain MR Images Acquired by a Dedicated Phased Array Coil  

E-Print Network [OSTI]

Cortical Enhanced Tissue Segmentation of Neonatal Brain MR Images Acquired by a Dedicated Phased Carolina at Chapel Hill Abstract The acquisition of high quality MR images of neonatal brains is largely hampered by their characteristically small head size and low tissue contrast. As a result, subsequent image

Utah, University of

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

E-Print Network 3.0 - adaptive bone remodelling Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

various sites and involves resorption by osteoclast, followed... mineral density and bone micro- architecture. Our paper focuses on bone microstructure and remodeling... in bone...

122

E-Print Network 3.0 - areal bone mineral Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

(DXA)-derived areal bone mineral density (BMD) and reductions in vertebral fracture incidence... than the bone volume fraction (mineralized bone volumebulk volume).12...

123

E-Print Network 3.0 - assessing bone mass Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

on assessment of bone mass... the amount of bone mass and predict the risk for fracture. However, the cur- rently available techniques... - tive assessment of bone ......

124

E-Print Network 3.0 - antibody-facilitated bone marrow Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of off... marrow, manifested as artifactual broadening of bone micro-structures in the image. The resulting images... (B0) at bone and bone marrow ... Source: Southern...

125

Final Report for completed IPP Project:"Development of Plasma Ablation for Soft Tissue and Bone Surgery"  

SciTech Connect (OSTI)

ArthroCare is a medical device company that develops, manufactures, and markets an advanced surgical tool, a plasma electro-surgical system for cutting and removing tissue. The hand-held electrical discharge device produces plasma in a biocompatible conductive fluid and tissue to which it is applied during surgery. Its products allow surgeons to operate with increased precision and accuracy, limiting damage to surrounding tissue thereby reducing pain and speeding recovery for the patient. In the past, the design of ArthfoCare's plasma wands has been an empirical undertaking. One goal of this R&D program was to put the phenomena involved on a sound scientific footing, allowing optimization of existing plasma based electro-surgery system technology, and the design and manufacture of new and improved kinds of scalpels, in particular for the surgical cutting of bone. Another important related goal of the program was to develop, through an experimental approach, new plasma wand approaches to the cutting ('shaving') of hard bone tissue. The goals of the CRADA were accomplished - computer models were used to predict important parameters of the plasma discharge and the bone environment, and several different approaches to bone-shaving were developed and demonstrated. The primary goal of the project was to develop and demonstrate an atmospheric-pressure plasma tool that is suitable for surgical use for shaving bone in humans. This goal was accomplished, in fact with several different alternative plasma approaches. High bone ablation speeds were measured. The use of probes ('plasma wand' - the surgical tool) with moving active electrodes was also explored, and there are advantages to this method. Another important feature is that the newly-exposed bone surface have only a very thin necrosis layer; this feature was demonstrated. This CRADA has greatly advanced our understanding of bone removal by atmospheric pressure plasmas in liquid, and puts ArthroCare in a good position to develop the techniques for commercial (surgical) application.

Brown, Ian

2009-09-01T23:59:59.000Z

126

CARBONATE STABLE ISOTOPES | Terrestrial Teeth and Bones  

Science Journals Connector (OSTI)

Teeth and bones of fossil vertebrates can preserve a record of Quaternary terrestrial environments in the form of isotopic compositions of carbon (13C/12C), nitrogen (15N/14N), and oxygen (18O/16O). These isotopic signatures in teeth and bones have yielded valuable information on the extent of savanna environments under tropical climates, on the ancient levels of aridity, on the spread of dense forests at the beginning of the Holocene, and on the paleodiet of hominids and their associated fauna.

H. Bocherens; D.G. Drucker

2007-01-01T23:59:59.000Z

127

CARBONATE STABLE ISOTOPES | Terrestrial Teeth and Bones  

Science Journals Connector (OSTI)

Abstract Teeth and bones of fossil vertebrates can preserve a record of Quaternary terrestrial environments in the form of the isotopic compositions of carbon (13C/12C), nitrogen (15N/14N), and oxygen (18O/16O). These isotopic signatures in teeth and bones have yielded valuable information on the extent of savanna environments under tropical climates, on the ancient levels of aridity, on the spread of dense forests at the beginning of the Holocene, and on the paleodiet of Hominids and their associated fauna.

H. Bocherens; D.G. Drucker

2013-01-01T23:59:59.000Z

128

Fixed endothelial cells exhibit physiologically relevant nanomechanics of the cortical actin web  

Science Journals Connector (OSTI)

It has been unknown whether cells retain their mechanical properties after fixation. Therefore, this study was designed to compare the stiffness properties of the cell cortex (the 50–100 nm thick zone below the plasma membrane) before and after fixation. Atomic force microscopy was used to acquire force indentation curves from which the nanomechanical cell properties were derived. Cells were pretreated with different concentrations of actin destabilizing agent cytochalasin D, which results in a gradual softening of the cell cortex. Then cells were studied 'alive' or 'fixed'. We show that the cortical stiffness of fixed endothelial cells still reports functional properties of the actin web qualitatively comparable to those of living cells. Myosin motor protein activity, tested by blebbistatin inhibition, can only be detected, in terms of cortical mechanics, in living but not in fixed cells. We conclude that fixation interferes with motor proteins while maintaining a functional cortical actin web. Thus, fixation of cells opens up the prospect of differentially studying the actions of cellular myosin and actin.

Kai Bodo Grimm; Hans Oberleithner; Johannes Fels

2014-01-01T23:59:59.000Z

129

Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering  

Science Journals Connector (OSTI)

Low oxygen pressure (hypoxia) plays an important role in stimulating angiogenesis; there are, however, few studies to prepare hypoxia-mimicking tissue engineering scaffolds. Mesoporous bioactive glass (MBG) has been developed as scaffolds with excellent osteogenic properties for bone regeneration. Ionic cobalt (Co) is established as a chemical inducer of hypoxia-inducible factor (HIF)-1?, which induces hypoxia-like response. The aim of this study was to develop hypoxia-mimicking MBG scaffolds by incorporating ionic Co2+ into MBG scaffolds and investigate if the addition of Co2+ ions would induce a cellular hypoxic response in such a tissue engineering scaffold system. The composition, microstructure and mesopore properties (specific surface area, nano-pore volume and nano-pore distribution) of Co-containing MBG (Co-MBG) scaffolds were characterized and the cellular effects of Co on the proliferation, differentiation, vascular endothelial growth factor (VEGF) secretion, HIF-1? expression and bone-related gene expression of human bone marrow stromal cells (BMSCs) in MBG scaffolds were systematically investigated. The results showed that low amounts of Co (ions into MBG scaffolds is a viable option for preparing hypoxia-mimicking tissue engineering scaffolds and significantly enhanced hypoxia function. The hypoxia-mimicking MBG scaffolds have great potential for bone tissue engineering applications by combining enhanced angiogenesis with already existing osteogenic properties.

Chengtie Wu; Yinghong Zhou; Wei Fan; Pingping Han; Jiang Chang; Jones Yuen; Meili Zhang; Yin Xiao

2012-01-01T23:59:59.000Z

130

In vitro and in vivo evaluation of akermanite bioceramics for bone regeneration  

Science Journals Connector (OSTI)

This study investigated the effects of a calcium magnesium silicate bioceramic (akermanite) for bone regeneration in vitro and in vivo, with ?-tricalcium phosphate (?-TCP) as a control. In vitro, the human bone marrow-derived mesenchymal stromal cells (hBMSCs) were cultured in an osteogenic medium supplemented with a certain concentration of two bioceramics' extracts for 20 days. An MTT assay showed that akermanite extract promoted proliferation of hBMSC significantly more than did ?-TCP extract. The results of alkaline phosphatase (ALP) activity test and the expression of osteogenic marker genes such as ALP, osteopontin (OPN), osteocalcin (OCN) and bone sialoprotein (BSP) demonstrated that the osteogenic differentiation of hBMSC was enhanced more by akermanite extract than by ?-TCP extract. In vivo, a histomorphology analysis and histomorphometry of the two porous bioceramics implants in rabbit femur defect models indicated that both in early- and late-stage implantations, akermanite promoted more osteogenesis and biodegradation than did ?-TCP; and in late-stage implantations, the rate of new bone formation was faster in akermanite than in ?-TCP. These results suggest that akermanite might be a potential and attractive bioceramic for tissue engineering.

Yan Huang; Xiaogang Jin; Xiaoling Zhang; Hongli Sun; Jinwen Tu; Tingting Tang; Jiang Chang; Kerong Dai

2009-01-01T23:59:59.000Z

131

Building Strong Bones: Calcium Information for Health Care Providers  

E-Print Network [OSTI]

intake of calcium.2 You can help children achieve lifelong bone health by talking to parents and young of calcium necessary for optimal bone development. Research suggests many parents don't know that children to three decades of life ·The rate at which bone is lost in the later years Although the consequences

Rau, Don C.

132

Modeling aspects of human memory for scientific study.  

SciTech Connect (OSTI)

Working with leading experts in the field of cognitive neuroscience and computational intelligence, SNL has developed a computational architecture that represents neurocognitive mechanisms associated with how humans remember experiences in their past. The architecture represents how knowledge is organized and updated through information from individual experiences (episodes) via the cortical-hippocampal declarative memory system. We compared the simulated behavioral characteristics with those of humans measured under well established experimental standards, controlling for unmodeled aspects of human processing, such as perception. We used this knowledge to create robust simulations of & human memory behaviors that should help move the scientific community closer to understanding how humans remember information. These behaviors were experimentally validated against actual human subjects, which was published. An important outcome of the validation process will be the joining of specific experimental testing procedures from the field of neuroscience with computational representations from the field of cognitive modeling and simulation.

Caudell, Thomas P. (University of New Mexico); Watson, Patrick (University of Illinois - Champaign-Urbana Beckman Institute); McDaniel, Mark A. (Washington University); Eichenbaum, Howard B. (Boston University); Cohen, Neal J. (University of Illinois - Champaign-Urbana Beckman Institute); Vineyard, Craig Michael; Taylor, Shawn Ellis; Bernard, Michael Lewis; Morrow, James Dan; Verzi, Stephen J.

2009-10-01T23:59:59.000Z

133

Bones as biofuel: a review of whale bone composition with implications for deep-sea biology and palaeoanthropology  

Science Journals Connector (OSTI)

...Review articles 1001 60 144 69 Bones as biofuel: a review of whale bone composition with...first attempts to quantify the enormous biofuel reserves of these giant creatures. The...smaller fatty acids. 3. Whale bones as biofuel These data have been unnoticed for half...

2011-01-01T23:59:59.000Z

134

Celebrating Black History Month with DOE's Sheri Bone | Department of  

Broader source: Energy.gov (indexed) [DOE]

with DOE's Sheri Bone with DOE's Sheri Bone Celebrating Black History Month with DOE's Sheri Bone February 9, 2011 - 2:04pm Addthis Sheri Bone. | File photo. Sheri Bone. | File photo. Ebony Meeks Former Assistant Press Secretary, Office of Public Affairs Throughout the month of February, we're introducing some remarkable African Americans who are working to advance the President's clean energy agenda and help the Department of Energy achieve its mission. This week we're profiling Sheri Bone who is Senior Project Director, Office of Nuclear Materials Integration, National Nuclear Security Administration. Sheri Bone Question: What is your key responsibility? SB: I'm responsible for developing the Department of Energy's strategic plan for nuclear materials. This means directing and leading a team of

135

L-line x-ray fluorescence of cortical bone lead compared with the CaNa2EDTA test in lead-toxic children: public health implications  

Science Journals Connector (OSTI)

...detector (EG & G Ortec, Oak Ridge, TN), a polarizer of...for tibial Pb in adult workers in lead industries are -30...In Pb-poisoned adult workers, correlation coefficients...normal adults and in lead workers (36, 37). BPb values...

J F Rosen; M E Markowitz; P E Bijur; S T Jenks; L Wielopolski; J A Kalef-Ezra; D N Slatkin

1989-01-01T23:59:59.000Z

136

Cortical pitch response components index stimulus onset/offset and dynamic features of pitch contours  

Science Journals Connector (OSTI)

Abstract Voice pitch is an important information-bearing component of language that is subject to experience dependent plasticity at both early cortical and subcortical stages of processing. We have already demonstrated that pitch onset component (Na) of the cortical pitch response (CPR) is sensitive to flat pitch and its salience. In regards to dynamic pitch, we do not yet know whether the multiple pitch-related transient components of the CPR reflect specific temporal attributes of such stimuli. Here we examine the sensitivity of the multiple transient components of CPR to changes in pitch acceleration associated with the Mandarin high rising lexical tone. CPR responses from Chinese listeners were elicited by three citation forms varying in pitch acceleration and duration. Results showed that the pitch onset component (Na) was invariant to changes in acceleration. In contrast, Na–Pb and Pb–Nb showed a systematic increase in the interpeak latency and decrease in amplitude with increase in pitch acceleration that followed the time course of pitch change across the three stimuli. A strong correlation with pitch acceleration was observed for these two components only – a putative index of pitch-relevant neural activity associated with the more rapidly-changing portions of the pitch contour. Pc–Nc marks unambiguously the stimulus offset. We therefore propose that in the early stages of cortical sensory processing, a series of neural markers flag different temporal attributes of a dynamic pitch contour: onset of temporal regularity (Na); changes in temporal regularity between onset and offset (Na–Pb, Pb–Nb); and offset of temporal regularity (Pc–Nc). At the temporal electrode sites, the stimulus with the most gradual change in pitch acceleration evoked a rightward asymmetry. Yet within the left hemisphere, stimuli with more gradual change were indistinguishable. These findings highlight the emergence of early hemispheric preferences and their functional roles as related to sensory and cognitive properties of the stimulus.

Ananthanarayan Krishnan; Jackson T. Gandour; Saradha Ananthakrishnan; Venkatakrishnan Vijayaraghavan

2014-01-01T23:59:59.000Z

137

A Multidomain Model for Ionic Electrodiffusion and Osmosis with an Application to Cortical Spreading Depression  

E-Print Network [OSTI]

Ionic electrodiffusion and osmotic water flow are central processes in many physiological systems. We formulate a system of partial differential equations that governs ion movement and water flow in biological tissue. A salient feature of this model is that it satisfies a free energy identity, ensuring the thermodynamic consistency of the model. A numerical scheme is developed for the model in one spatial dimension and is applied to a model of cortical spreading depression, a propagating breakdown of ionic and cell volume homeostasis in the brain.

Yoichiro Mori

2014-10-30T23:59:59.000Z

138

Local drug delivery for enhancing fracture healing in osteoporotic bone  

Science Journals Connector (OSTI)

Abstract Fragility fractures can cause significant morbidity and mortality in patients with osteoporosis and inflict a considerable medical and socioeconomic burden. Moreover, treatment of an osteoporotic fracture is challenging due to the decreased strength of the surrounding bone and suboptimal healing capacity, predisposing both to fixation failure and non-union. Whereas a systemic osteoporosis treatment acts slowly, local release of osteogenic agents in osteoporotic fracture would act rapidly to increase bone strength and quality, as well as to reduce the bone healing period and prevent development of a problematic non-union. The identification of agents with potential to stimulate bone formation and improve implant fixation strength in osteoporotic bone has raised hope for the fast augmentation of osteoporotic fractures. Stimulation of bone formation by local delivery of growth factors is an approach already in clinical use for the treatment of non-unions, and could be utilized for osteoporotic fractures as well. Small molecules have also gained ground as stable and inexpensive compounds to enhance bone formation and tackle osteoporosis. The aim of this paper is to present the state of the art on local drug delivery in osteoporotic fractures. Advantages, disadvantages and underlying molecular mechanisms of different active species for local bone healing in osteoporotic bone are discussed. This review also identifies promising new candidate molecules and innovative approaches for the local drug delivery in osteoporotic bone.

Laura Kyllönen; Matteo D’Este; Mauro Alini; David Eglin

2014-01-01T23:59:59.000Z

139

Is pelvic bone mineral content assessed through dual energy X-ray absorptionmetry an appropriate anatomical area for bone mass estimation in women?  

Science Journals Connector (OSTI)

Bibliographic references seem very controversill regarding the most appropriate anatomical area for bone mass estimation. Since some overlapping in the different bone mass measurements among normal and osteopo...

Prof. Dr. H. Rico; M. Revilla; E. R. Hernández; L. F. Villa…

1992-12-01T23:59:59.000Z

140

Human Ecology Human ecology Research  

E-Print Network [OSTI]

Human Ecology Impact of Human ecology Research Bonus Issue FROM SCHOLARSHIP TO POLICY MAKING OF HUMAN ECOLOGY APRIL 2005/VOLUME 33, NUMBER 1 #12;Human Ecology Volume 33, Number 1 April 2005 The New York State College of Human Ecology at Cornell University Lisa Staiano-Coico, Ph.D. Rebecca Q

Wang, Z. Jane

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Bone Cancer Rates in Dinosaurs Compared with Modern Vertebrates  

E-Print Network [OSTI]

Data on the prevalence of bone cancer in dinosaurs is available from past radiological examination of preserved bones. We statistically test this data for consistency with rates extrapolated from information on bone cancer in modern vertebrates, and find that there is no evidence of a different rate. Thus, this test provides no support for a possible role of ionizing radiation in the K-T extinction event.

L. C. Natarajan; A. L. Melott; B. M. Rothschild; L. D. Martin

2007-10-16T23:59:59.000Z

142

On nano size structures for enhanced bone formation.  

E-Print Network [OSTI]

??Purpose The general aim of the present thesis was to investigate early bone response to titanium implants modified with nano size structures. Therefore, 1. a… (more)

Meirelles, Luiz

2007-01-01T23:59:59.000Z

143

E-Print Network 3.0 - acute bone crises Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mography. Bone... Subchondral Bone Analyses by Micro-Computed Tomography Catherine Marchand, Ph.D.,1 Hongmei Chen, Ph.D.,1... to analyze subchondral bone features below treated...

144

Protocadherin-7 induces bone metastasis of breast cancer  

SciTech Connect (OSTI)

Highlights: •PCDH7 is overexpression in high bone metastatic MDA-MB-231 cells. •PCDH7 is up-regulation in bone metastatic breast cancer tissues. •Suppression of PCDH7 inhibits cell proliferation, migration, and invasion in vitro. •PCDH7 induces breast cancer bone metastasis in vivo. -- Abstract: Breast cancer had a propensity to metastasize to bone, resulting in serious skeletal complications associated with poor outcome. Previous study showed that Protocadherin-7 (PCDH7) play an important role in brain metastatic breast cancer, however, the role of PCDH7 in bone metastatic breast cancer has never been explored. In the present study, we found that PCDH7 expression was up-regulation in bone metastatic breast cancer tissues by real-time PCR and immunohistochemistry assays. Furthermore, suppression of PCDH7 inhibits breast cancer cell proliferation, migration, and invasion in vitro by MTT, scratch, and transwell assays. Most importantly, overexpression of PCDH7 promotes breast cancer cell proliferation and invasion in vitro, and formation of bone metastasis in vivo. These data provide an important insight into the role of PCDH7 in bone metastasis of breast cancer.

Li, Ai-Min [Department of Orthopedics, The 5th Central Hospital of Tianjin, Tianjin (China)] [Department of Orthopedics, The 5th Central Hospital of Tianjin, Tianjin (China); Tian, Ai-Xian [Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)] [Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Zhang, Rui-Xue [Department of Clinical Laboratory Diagnosis, Tianjin Medical University, Tianjin (China)] [Department of Clinical Laboratory Diagnosis, Tianjin Medical University, Tianjin (China); Ge, Jie [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Sun, Xuan [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)] [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Cao, Xu-Chen, E-mail: caoxuch@126.com [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)

2013-07-05T23:59:59.000Z

145

E-Print Network 3.0 - adam12-s stimulates bone Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and computer... design (dimensions, profile shape and material properties) on the load sharing with adjacent bone... and consequent bone resorption was tested, using a set of...

146

Supercritical carbon dioxide-processed resorbable polymer nanocomposites for bone graft substitute applications.  

E-Print Network [OSTI]

?? Numerous clinical situations necessitate the use of bone graft materials to enhance bone formation. While autologous and allogenic materials are considered the gold standards… (more)

Baker, Kevin

2011-01-01T23:59:59.000Z

147

E-Print Network 3.0 - aspirate bone graft Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

-based implants for bone reconstruction and repair. We have developed HA-coated carbon-fiber polymer composites... that match bone's elastic modulus and show advantageous in...

148

E-Print Network 3.0 - artificial bone substitute Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales Summary: to its biomedical significance, bone has been used...

149

E-Print Network 3.0 - affecting bone mineral Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of remodeling on the mineralization of bone... of therapies that reduce the risk of fracture, increase bone mineral density or change the biochemical markers... mass and...

150

E-Print Network 3.0 - activity bone mineral Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of remodeling on the mineralization of bone... of therapies that reduce the risk of fracture, increase bone mineral density or change the biochemical markers... mass and...

151

E-Print Network 3.0 - adsorbed bone sialoprotein Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

mass Philipp J. Thurner a... 2010 Edited by: D. Burr Keywords: Osteopontin Rodent Fracture toughness Bone matrix properties... Mineralization The ability of bone to resist...

152

E-Print Network 3.0 - anorganic bone clinical Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

predictor of bone mass... formation from bone marrow progenitors. Journal of ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

153

E-Print Network 3.0 - adverse events bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by Explorit Topic List Advanced Search Sample search results for: adverse events bone Page: << < 1 2 3 4 5 > >> 1 Mechanoregulated bone adaptation in osteoarthritis This...

154

Patients with Patellofemoral Pain Exhibit Elevated Bone Metabolic Activity at the Patellofemoral Joint  

E-Print Network [OSTI]

for bone mineral,10 are injected intravenously. The 18 F fluoride ions exchange with hydroxl ions in bone and pain. Technetium-99m hydroxymethylene diphosphonate (Tc-99m MDP) bone scintigraphy previ- ously bone metabolic activity. In this imaging technique, 18 F fluoride ions, which have a high affinity

Delp, Scott

155

Patients with Patellofemoral Pain Exhibit Elevated Bone Metabolic Activity at the Patellofemoral Joint  

E-Print Network [OSTI]

for bone mineral,10 are injected intravenously. The 18 F fluoride ions exchange with hydroxl ions in bone stress and pain. Technetium-99m hydroxymethylene diphosphonate (Tc-99m MDP) bone scintigraphy previ bone metabolic activity. In this imaging technique, 18 F fluoride ions, which have a high affinity

Delp, Scott

156

The effect of iron chloride and glutamate on glutamine synthetase activity in primary cultured rat cortical astrocytes: a model for epileptic induction  

E-Print Network [OSTI]

THE EFFECT OF IRON CHLORIDE AND GLUTAMATE ON GLUTAMINE SYNTHETASE ACTIVITY IN PRIMARY CULTURED RAT CORTICAL ASTROCYTES: A MODEL POR EPILEPTIC INDUCTION A Thesis by JULIE ANN ROBERTS Submitted to the Graduate College of Texas ARM University... in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE December 1986 Major Subject: Veterinary Anatomy THE EFFECT OF IRON CHLORIDE AND GLUTAMATE ON GLUTAMINE SYNTHETASE ACTIVITY IN PRIMARY CULTURED RAT CORTICAL ASTROCYTES: A...

Roberts, Julie Ann

1986-01-01T23:59:59.000Z

157

Osseous penetration rate into implants pretreated with bone cement  

Science Journals Connector (OSTI)

The titanium bone growth chamber consists of two titanium disks held together by two screws. At the level of the intersection between the disks, a 1 mm wide canal penetrates the implant. After implantation, in e....

T. Albrektsson

1984-01-01T23:59:59.000Z

158

Compact biomedical pulsed signal generator for bone tissue stimulation  

DOE Patents [OSTI]

An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

Kronberg, J.W.

1993-06-08T23:59:59.000Z

159

Compact biomedical pulsed signal generator for bone tissue stimulation  

DOE Patents [OSTI]

An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

Kronberg, James W. (108 Independent Blvd., Aiken, SC 29801)

1993-01-01T23:59:59.000Z

160

Autoradiographic evidence of nuclear binding of spironolactone in rabbit cortical collecting tubule  

SciTech Connect (OSTI)

Previous biochemical studies indicated that the spirolactone-mineralocorticoid receptor complexes are unable to translocate into the nucleus. The present study was designed to reinvestigate the intracellular distribution of spirolactone-binding sites, using autoradiography. For this purpose, rabbit kidney pyramids were incubated at 30 C with tritiated SC9420 or aldosterone. Thereafter, aldosterone-sensitive cortical collecting tubules were microdissected and processed for dry film autoradiography. The concentration was 2 nM for both steroids. Non-specific labeling was determined by incubations with tritiated steroids plus a 100-fold excess of unlabeled steroids. Results show the presence of specific nuclear labeling for both ({sup 3}H) aldosterone and ({sup 3}H)SC9420. Specific cytoplasmic labeling was very low for both ({sup 3}H)aldosterone and ({sup 3}H)SC9420. The nuclear labeling by ({sup 3}H)SC9420 was equally and almost completely displaced by a 100-fold excess of unlabeled aldosterone or SC9420 (91% and 87%, respectively). We conclude that spironolactone-receptor complexes migrate into the nucleus. The difference between these results and those of previous studies with biochemical techniques, which failed to detect specific nuclear binding of spirolactone, may be due to methodological reasons.

Bonvalet, J.P.; Blot-Chabaud, M.; Farman, N. (CEN Saclay, Gif-Yvette (France))

1991-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Cortical pitch response components show differential sensitivity to native and nonnative pitch contours  

Science Journals Connector (OSTI)

Abstract The aim of this study is to evaluate how nonspeech pitch contours of varying shape influence latency and amplitude of cortical pitch-specific response (CPR) components differentially as a function of language experience. Stimuli included time-varying, high rising Mandarin Tone 2 (T2) and linear rising ramp (Linear), and steady-state (Flat). Both the latency and magnitude of CPR components were differentially modulated by (i) the overall trajectory of pitch contours (time-varying vs. steady-state), (ii) their pitch acceleration rates (changing vs. constant), and (iii) their linguistic status (lexical vs. non-lexical). T2 elicited larger amplitude than Linear in both language groups, but size of the effect was larger in Chinese than English. The magnitude of CPR components elicited by T2 were larger for Chinese than English at the right temporal electrode site. Using the CPR, we provide evidence in support of experience-dependent modulation of dynamic pitch contours at an early stage of sensory processing.

Ananthanarayan Krishnan; Jackson T. Gandour; Chandan H. Suresh

2014-01-01T23:59:59.000Z

162

Evaluation of radionuclide bone-imaging for the early detection of sepsis in a model of equine neonatal osteomyelitis  

E-Print Network [OSTI]

method of detecting bone abnormalities. The two main factors determining the degree of radiopharmaceutical uptake in bones, and thereby assessing the functional integrity of bone, have been identified as bone blood flow and bone turnover rates.... The resultant infection and induced metabolic changes should produce a positive Technetium-99m MDP ( Tc-MDP) 99m bone scan, a positive scan using Indium-111-oxine labeled leukocytes and radiographic changes characterized by decreased bone density . Seven...

Taylor, James Rutledge

1986-01-01T23:59:59.000Z

163

Adolescents with prenatal cocaine exposure show subtle alterations in striatal surface morphology and frontal cortical volumes  

E-Print Network [OSTI]

of prenatal cocaine exposure (PCE) in humans have yieldedin adolescents with PCE compared to control participants.significantly differ between PCE participants and controls.

2012-01-01T23:59:59.000Z

164

Trabecular bone dosimetry using a Monte Carlo code  

E-Print Network [OSTI]

The nuclear medicine community needs radiation ~ dose estimates to patients who are administered radiopharmaceuticals for therapy or diagnosis. These estimates should be as accurate as possible for any organ, and especially for the bone since the bone... of Nuclear Medicine formed a committee to fulfill the needs of the nuclear medicine community to determine the radiation absorbed dose to patients who are athninistered radiopharmaceuticals. The objectives of the Medical Internal Radiation Dose Committee...

Zuzarte de Mendonca, Anne

1993-01-01T23:59:59.000Z

165

Ibuprofen Administered Pre- or Post- Simulated Resistance Exercise Training Does Not Diminsh Gains in Bone Formation or Bone Mass  

E-Print Network [OSTI]

Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to suppress bone formation when administered before, but not if administered after, an acute bout of mechanical load in rats. The NSAID ibuprofen inhibits cyclooxygenase-2 enzyme...

Cunningham, David

2012-02-14T23:59:59.000Z

166

Histologic Comparison of Regenerate Bone Produced from Dentate Versus Edentulous Transport Discs in Bone Transport Distraction Osteogenesis  

E-Print Network [OSTI]

i HISTOLOGIC COMPARISON OF REGENERATE BONE PRODUCED FROM DENTATE VERSUS EDENTULOUS TRANSPORT DISCS IN BONE TRANSPORT DISTRACTION OSTEOGENESIS A Thesis by CARLOS SEVILLA GAITÁN Submitted to The Office of Graduate and Professional Studies... Paul Dechow Head of Department, William W. Nagy December 2013 Major Subject: Oral Biology Copyright 2013 Carlos Sevilla Gaitan ii ABSTRACT Purpose: The purpose of this research was to quantify the number of blood vessels...

Sevilla Gaitan, Carlos

2013-12-10T23:59:59.000Z

167

Na sup + -K sup + -ATPase-dependent sodium flux in cortical collecting tubule  

SciTech Connect (OSTI)

The instantaneous rate of efflux of intracellular Na was studied in rabbit isolated cortical collecting tubules (CCT) as a function of temperature and intracellular Na concentration ((Na){sub i}). (Na){sub i} of microdissected CCT was increased by cold and K-free exposure in the presence of {sup 22}Na and the extracellular tracer ({sup 3}H)sorbitol. (Na){sub i} rose rapidly to 40 mM at 30 min, after which it rose more slowly, reaching 120-140 mM at 6 h. Kinetics of Na efflux were studied after rapid rewarming, using a special device allowing measurements at 20-s intervals. Under control conditions, the total Na load was extruded in <8 min, whereas, in the presence of 10{sup {minus}4} M ouabain, only 50% of the load was extruded during this period of time. Ouabain-sensitive Na efflux was first evident at 13{degree}C and gradually increased between 13 and 35{degree}C. At 37{degree}C, Na{sup +}-K{sup +}-ATPase-dependent Na efflux was dependent on (Na){sub i}. This efflux gradually increased, from 0.05 to 0.5 peq{center dot}nl tubular volume{sup {minus}1}{center dot}s{sup {minus}1} as a function of (Na){sub i} and reached a plateau at 70 mM (Na){sub i}. It is concluded that (Na){sub i} is a major modulator of the pump activity in CCT; at normal levels of (Na){sub i}, the pump is operating at only a small fraction of its total capacity.

Blot-Chabaud, M.; Jaisser, F.; Gingold, M.; Bonvalet, J.P.; Farman, N. (CEntre d'Etudes Nucleaires de Saclay, Gif sur Yvette (France))

1988-10-01T23:59:59.000Z

168

Localization of Cortical Phase and Amplitude Dynamics during Visual Working Memory Encoding and Retention  

E-Print Network [OSTI]

Several studies show that the amplitudes of human brain oscillations are modulated during the performance of visual working memory (VWM) tasks in a load-dependent manner. Less is known about the dynamics and identities of ...

Palva, Satu

169

Evaluation of HIV-1 Tat induced neurotoxicity in rat cortical cell culture  

Science Journals Connector (OSTI)

In a substantial number of cases, Human Immunodeficiency Virus type 1 (HIV-1) infection causes neuronal cell loss and ... loss. Here we studied the effect of HIV-1 Tat in primary rat neuronal cells as a ... cell ...

Aleida Pérez; Albert W. Probert; Kevin K. W. Wang…

2001-01-01T23:59:59.000Z

170

Human Nature  

Science Journals Connector (OSTI)

In the human enhancement debate, both parties advocate a partial truth. On the one hand, the bioconservatives argue that, if transhumanism is unleashed without some kind of bioethical...have (A+) is itself a prod...

Prof.; Dr. Hub Zwart

2014-08-01T23:59:59.000Z

171

Human Enhancement  

Science Journals Connector (OSTI)

Abstract Categorizing different human enhancements into personal, social, or species enhancements, as well as considering whether a particular enhancement technique generates asymmetric or network benefits, brings clarity to discussions about the ethical issues pertaining to any individual technique. The four aspects of principlism can help to assess the ethical implications of different human enhancements, revealing complexities in their aspirational claims for personally directed self-development. At a practical level, this article examines important questions about real expectations, scientific hubris, and hype.

P. Moore

2012-01-01T23:59:59.000Z

172

Common variants in the region around Osterix are associated with bone mineral density and growth in childhood  

E-Print Network [OSTI]

Peak bone mass achieved in adolescence is a determinant of bone mass in later life. In order to identify genetic variants affecting bone mineral density (BMD), we performed a genome-wide association study of BMD and related ...

Peltonen, Leena

173

Bone breakage in laying hens as affected by dietary supplements  

E-Print Network [OSTI]

BONE BREAKAGE IN LAYING HENS AS AFFECTED BY DIETARY SUPPLEMENTS A Thesis by DAVID JOE MOORE Submitted to the Graduate College of Texas Al!M University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE August 1975... Major Subject: Poultry Science (Physiology) BONE BREAKAGE IN LAYING HENS AS AFFECTED BY DIETARY SUPPLEMENTS A Thesis by DAVID JOE MOORE Approved as to style and content by: Chairman of Comm' ee ad o Department) Member Member '7 I ls&wr g ~, /0...

Moore, David Joe

1975-01-01T23:59:59.000Z

174

E-Print Network 3.0 - attenuates bone cancer Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

cancer Search Powered by Explorit Topic List Advanced Search Sample search results for: attenuates bone cancer Page: << < 1 2 3 4 5 > >> 1 Questions and Answers About Bone Cancer...

175

Processing of bone samples for the determination of ultra low-levels of uranium and plutonium  

Science Journals Connector (OSTI)

We have developed cleanroom compatible techniques for processing bone samples for ... dried and ashed in quartz crucibles placed inside cleanroom compatible thermal ashing furnaces. The bone ash...238U and 8 femt...

D. W. Efurd; R. E. Steiner; S. P. LaMont…

2006-09-01T23:59:59.000Z

176

Quantitative assessment of bone mineral content in dental radiography —Methodology and clinical usefulness  

Science Journals Connector (OSTI)

Various techniques have been developed for measuring bone mineral content in medical examination and treatment these days1–6). In the dento-maxilo-facial region, mandibular bone mineral content has been investiga...

Takenori Noikura

1996-12-01T23:59:59.000Z

177

E-Print Network 3.0 - air bone particles Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

2 3 4 5 > >> 1 Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone Summary: of trabecular bone Georg E. Fantnera,*, Henrik...

178

Structure and functionalization of mesoporous bioceramics for bone tissue regeneration and local drug delivery  

Science Journals Connector (OSTI)

...promote the bone regeneration process. mesoporous bioceramics...accelerating the healing process. Thus, the design, development and commercialization of bioactive and biodegradable...elements play key roles in the processes that promote bone formation...

2012-01-01T23:59:59.000Z

179

Triple-Energy X-Ray Absorptiometry for Determination of the Bone Mineral Content in Vivo  

Science Journals Connector (OSTI)

Dual-energy X-ray absorptiometry (DXA) is a ... method for the determination of the bone mineral content in vivo. It has a high precision ... bone. The present work describes a triple-energy X-ray absorptiometry ...

Janos Szücs; Ragnar Jonson; Tommy Hansson

1993-01-01T23:59:59.000Z

180

Apatite-polymer composites for the controlled delivery of bone morphogenetic proteins  

E-Print Network [OSTI]

Current treatment of bone defects due to trauma, cancer, or degenerative spine diseases involves the implantation of a bone graft. Autografts, which are harvested from the patient's own body, are associated with problems ...

Yong, Tseh-Hwan

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

Visualizing biointerfaces in three dimensions: electron tomography of the bone–hydroxyapatite interface  

Science Journals Connector (OSTI)

...to three-dimensional analysis is becoming standard practice...routine three-dimensional analysis...biomaterial-bone interfaces by other...bone-scaffold interface and using...a three-dimensional reconstruction...tilt series measuring 320 260 70...

2010-01-01T23:59:59.000Z

182

E-Print Network 3.0 - acid reduces bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

properties in dog rib. J Bone... the Quality of Bone Tissue Stefan Judex, PhD*, Steve Boyd, PhD, Yi-Xian Qin, PhD, Lisa Miller, PhD, Ralph... is to withstand the loads and...

183

The consequence of late-onset alcohol abuse in aged bone: a histomorhometric analysis  

E-Print Network [OSTI]

of decreased intake and absorption, bone quality is negatively affected because of the decrease in nutrients that determine bone health (calcium, phosphorus, magnesium and vitamin D). Certain age-related physiological changes also promote osteoporosis... of ethanol treatment. Upon analysis of the bone content, they found that alcohol did not have an afFect on the bone mineral content such as calcium, magnesium, and phosphorus. Peng et. al. suggested that alcohol may induce an alteration...

Barker, Lisa Setchfield

2012-06-07T23:59:59.000Z

184

On the fracture of human dentin: Is it stress-or strain-controlled?  

E-Print Network [OSTI]

On the fracture of human dentin: Is it stress- or strain-controlled? R. K. Nalla,1 J. H. Kinney,2 R information in archival literature that can be usefully used to model such fracture. In fact, although the fracture event in dentin, akin to other mineralized tissues like bone, is widely believed to be locally

Ritchie, Robert

185

Bone marrow stromal cells increase oligodendrogenesis after stroke  

E-Print Network [OSTI]

Bone marrow stromal cells increase oligodendrogenesis after stroke Jing Zhang1 , Yi Li1 , Zheng cell (BMSC) treatment of stroke in rats. Rats were subjected to the middle cerebral artery occlusion (MCAo). BMSCs have been shown to promote functional recovery post stroke. A therapeutic dose of BMSC (3

Cai, Long

186

Trabecular bone scales allometrically in mammals and birds  

Science Journals Connector (OSTI)

...1086/284325 ) 24 Silva, M. 1995 CRC Handbook of mammalian body masses. Boca Raton...Press. 25 Dunning, J. B. 2008 CRC handbook of avian body masses. 2nd edn. Boca...kg. We found that bone volume fraction does not scale substantially with animal size...

2011-01-01T23:59:59.000Z

187

Nukbone® promotes proliferation and osteoblastic differentiation of mesenchymal stem cells from human amniotic membrane  

SciTech Connect (OSTI)

Highlights: •Nukbone showed to be a good scaffold for adhesion, proliferation and differentiation of stem cells. •Nukbone induced osteoblastic differentiation of human mesenchymal stem cells. •Results showed that Nukbone offer an excellent option for bone tissue regeneration due to properties. -- Abstract: Bovine bone matrix Nukbone® (NKB) is an osseous tissue-engineering biomaterial that retains its mineral and organic phases and its natural bone topography and has been used as a xenoimplant for bone regeneration in clinics. There are not studies regarding its influence of the NKB in the behavior of cells during the repairing processes. The aim of this research is to demonstrate that NKB has an osteoinductive effect in human mesenchymal stem cells from amniotic membrane (AM-hMSCs). Results indicated that NKB favors the AM-hMSCs adhesion and proliferation up to 7 days in culture as shown by the scanning electron microscopy and proliferation measures using an alamarBlue assay. Furthermore, as demonstrated by reverse transcriptase polymerase chain reaction, it was detected that two gene expression markers of osteoblastic differentiation: the core binding factor and osteocalcin were higher for AM-hMSCs co-cultured with NKB in comparison with cultivated cells in absence of the biomaterial. As the results indicate, NKB possess the capability for inducing successfully the osteoblastic differentiation of AM-hMSC, so that, NKB is an excellent xenoimplant option for repairing bone tissue defects.

Rodríguez-Fuentes, Nayeli; Rodríguez-Hernández, Ana G. [Depto. Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510 (Mexico)] [Depto. Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Mexico City 04510 (Mexico); Enríquez-Jiménez, Juana [Depto. Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), México City 14000 (Mexico)] [Depto. Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INCMNSZ), México City 14000 (Mexico); Alcántara-Quintana, Luz E. [Subd. de Investigación, Centro Nacional de la Transfusión Sanguínea, Secretaria de Salud, Mexico City 07370 (Mexico)] [Subd. de Investigación, Centro Nacional de la Transfusión Sanguínea, Secretaria de Salud, Mexico City 07370 (Mexico); Fuentes-Mera, Lizeth [Depto. Biología Molecular e Histocompatibilidad, Hospital General “Dr. Manuel Gea González”, México City 4800 (Mexico)] [Depto. Biología Molecular e Histocompatibilidad, Hospital General “Dr. Manuel Gea González”, México City 4800 (Mexico); Piña-Barba, María C. [Depto. Materiales Metálicos y Cerámicos, Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México (UNAM), México City 04510 (Mexico)] [Depto. Materiales Metálicos y Cerámicos, Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México (UNAM), México City 04510 (Mexico); Zepeda-Rodríguez, Armando [Depto. Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México City 04510 (Mexico)] [Depto. Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), México City 04510 (Mexico); and others

2013-05-10T23:59:59.000Z

188

Evaluation of bone response to synthetic bone grafting material treated with argon-based atmospheric pressure plasma  

Science Journals Connector (OSTI)

Abstract Bone graft materials are utilized to stimulate healing of bone defects or enhance osseointegration of implants. In order to augment these capabilities, various surface modification techniques, including atmospheric pressure plasma (APP) surface treatment, have been developed. This in vivo study sought to assess the effect of APP surface treatment on degradation and osseointegration of Synthograft™, a beta-tricalcium phosphate (?-TCP) synthetic bone graft. The experimental (APP-treated) grafts were subjected to APP treatment with argon for a period of 60 s. Physicochemical characterization was performed by environmental scanning electron microscopy, surface energy (SE), and x-ray photoelectron spectroscopy analyses both before and after APP treatment. Two APP-treated and two untreated grafts were surgically implanted into four critical-size calvarial defects in each of ten New Zealand white rabbits. The defect samples were explanted after four weeks, underwent histological analysis, and the percentages of bone, soft tissue, and remaining graft material were quantified by image thresholding. Material characterization showed no differences in particle surface morphology and that the APP-treated group presented significantly higher SE along with higher amounts of the base material chemical elements on it surface. Review of defect composition showed that APP treatment did not increase bone formation or reduce the amount of soft tissue filling the defect when compared to untreated material. Histologic cross-sections demonstrated osteoblastic cell lines, osteoid deposition, and neovascularization in both groups. Ultimately, argon-based APP treatment did not enhance the osseointegration or degradation of the ?-TCP graft. Future investigations should evaluate the utility of gases other than argon to enhance osseointegration through APP treatment.

Bryan G. Beutel; Natalie R. Danna; Riddhi Gangolli; Rodrigo Granato; Lakshmiprada Manne; Nick Tovar; Paulo G. Coelho

2014-01-01T23:59:59.000Z

189

Automatic Feature-based Surface Mapping for Brain Cortices Fabien Vivodtzev1 David F. Wiley2 Lars Linsen3 James Jones2 Nina Amenta2  

E-Print Network [OSTI]

Automatic Feature-based Surface Mapping for Brain Cortices Fabien Vivodtzev1 David F. Wiley2 Lars effort is to develop technology for automatically transferring surface annotations from an atlas brain to a subject brain. While macroscopic regions of brain surfaces often correspond, the detailed surface geometry

Linsen, Lars

190

Current Biology 16, 20232029, October 24, 2006 2006 Elsevier Ltd All rights reserved DOI 10.1016/j.cub.2006.08.084 Cortical Responses to Invisible  

E-Print Network [OSTI]

.1016/j.cub.2006.08.084 Report Cortical Responses to Invisible Faces: Dissociating Subsystems for Facial neutral, fearful, and scrambled faces, either visible or rendered invisible through interocular responded strongly to visible faces. However, when face images became invisible, activity in FFA to both

He, Sheng

191

High resolution cortical thickness measurement from clinical CT data G.M. Treece, A.H. Gee, P.M. Mayhew and K.E.S. Poole  

E-Print Network [OSTI]

) methods of assessing hip structure, most notably with multi-detector computed tomography, MDCT (Bouxsein and technically limited by thresholding errors caused by relatively low resolution data sets. Ideally, we wouldHigh resolution cortical thickness measurement from clinical CT data G.M. Treece, A.H. Gee, P

Drummond, Tom

192

On the multiscale origins of fracture resistance in human bone and its biological degradation  

E-Print Network [OSTI]

the   inherent   resistance   of   the   material   to  i.e. ,  the  material’s  resistance  to  crack  extension.  

Zimmermann, Elizabeth A.

2012-01-01T23:59:59.000Z

193

Vitamin D Deficiency Promotes Human Breast Cancer Growth in a Murine Model of Bone Metastasis  

Science Journals Connector (OSTI)

...Sigma-Aldrich) at concentrations of 107, 108, and 109 mol/L or vehicle (ethanol) was added on day 1 with replacement every 24 h...Public Health 2006;96:252-61. 2 Grant WB Mohr SB. Ecological studies of ultraviolet B, vitamin D and cancer since 2000...

Li Laine Ooi; Hong Zhou; Robert Kalak; Yu Zheng; Arthur D. Conigrave; Markus J. Seibel; and Colin R. Dunstan

2010-03-01T23:59:59.000Z

194

Detection of bone disease in dogs by radioisotope scanning  

E-Print Network [OSTI]

, delayed union, and nonunion), osteomyelitis, degenerative arthritis, surgical osteotomy, i'ibrous dysplasia, osteochondromatosie, and growing epiphyses. Radioisotopic scanning has been reported 12 for studying the metabolism of Fluorine-18 in dogs 9..., ( 1962): 95-104. 2. Bauer, G. C. H. , and Smith, E. M. r Sr 85 Sointimetry in Osteoarthritis of the Knee. J . Nucl. Med. , 10, (Mar. , 1969): 109-116. Blau, M. , Nagler, W. , and Bender, M. A. : Fluorine ? 18. A New Isotope for Bone Scanning. J. Nucl...

Morris, Earl Louis

2012-06-07T23:59:59.000Z

195

Correction for Higgs et al., Bones as biofuel: a review of whale bone composition with implications for deep-sea biology and palaeoanthropology  

Science Journals Connector (OSTI)

...Journal is 2010 The Royal Society 22 March 2011 correction Corrections 1001 144 60 69 Correction for Higgs et al., Bones as biofuel: a review of whale bone composition with implications for deep-sea biology and palaeoanthropology Nicholas D. Higgs Crispin...

2011-01-01T23:59:59.000Z

196

Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Synchrotron  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Archaeopteryx Feathers and Bone Chemistry Fully Revealed via Synchrotron Imaging Archaeopteryx specimens are important but extremely rare fossils. Due to their possession of both reptilian (jaws with teeth, long bony tail) and avian (feathered wings) characters, Archaeopteryx has been crucial in the development of Darwinian evolution. Despite their importance, no Archaeopteryx specimen has ever been chemically analyzed. This in large part may be explained by the analytical obstacles which preclude applying standard methods to such valuable specimens; destructive sampling is not an option and most non-destructive methods cannot handle large specimens. Furthermore, mapping using conventional methods is far too slow to enable chemical zonation to be reasonably determined. Mapping of trace element chemistry is of tremendous interest, however, because it opens a window into understanding several critical questions about Archaeopteryx in particular, and about fossil specimens in general. Preserved trace chemistry in bones and soft tissue may be remnants of the living organism, and therefore may give insight into life processes of extinct organisms. When mapping includes the embedding rock matrix, mass transfer between the fossil and the matrix can be constrained, hence giving information about mode of preservation. Chemical analysis can also resolve artefacts of the curation process. Finally, accurate chemical maps can also be useful for directing future work by highlighting regions that may be promising for other types of analysis including structural methods (CT, diffraction) or techniques that use other parts of the electromagnetic spectrum (infra-red).

197

3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone at the  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone 3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone at the Nanoscale Scientists studying osteoporosis and other skeletal diseases are interested in the 3D structure of bone and its responses to conditions such as weightlessness, radiation (of particular interest to astronauts) and vitamin D deficiency. The current gold standard, micro-computed tomography (micro-CT), provides 3D images of trabeculae, the small interior struts of bone tissue, and electron microscopy can provide nanometer resolution of thin tissue slices. Hard X-ray transmission microscopy has provided the first 3D view of bone structure within individual trabeculae on the nanoscale. figure 1 Figure 1 Micro-CT (left) shows trabecular structure inside of bone. Transmission X-ray microscopy (TXM; center and right) can reveal localized details of osteocyte lacunae and their processes.

198

The X-ray attenuation characteristics and density of human calcaneal marrow do not change significantly during adulthood  

E-Print Network [OSTI]

The X-ray attenuation characteristics and density of human calcaneal marrow do not change be a significant source of error in measurements of bone density when using X-ray and ultrasound imaging modalities calcanei (28 males, 6 females, ages 17­65 years). The density and energy-dependent linear X-ray attenuation

Stanford University

199

Enhancement of Growth Performance and Bone Mineralization in Market Broilers through Dietary Enzymes  

E-Print Network [OSTI]

. In Experiment 1, a 35-day grow out trial was conducted to investigate the effect of three commercially available phytase enzymes on growth performance and bone mineralization in phosphorus deficient corn/soy based diets. Increasing the level of available... phosphorus (aP) in the control diets resulted in improved bird performance and bone ash data. The presence of dietary phytase in phosphorus deficient diets resulted in improvements in growth parameters and bone mineralization. Regression analysis...

Coppedge, Jacob Ryan

2012-02-14T23:59:59.000Z

200

E-Print Network 3.0 - asymptomatic local bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Collection: Engineering ; Biology and Medicine 42 Science Highlight June 2010 Figure 1: Micro-CT (left) shows trabecular structure inside of bone. Transmission X-ray Summary: ....

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

E-Print Network 3.0 - acetabular bone defect Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Journal of Arthroplasty Vol. 14 No. 7 1999 Case Report Summary: modular head and polyethylene liner. Bone defects were filled with morcellized allograft. Three months......

202

E-Print Network 3.0 - alveolar bone loss Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

extended period of ossification. Most dermal bones begin ossification before ... Source: Smith, Kathleen K. - Department of Biology, Duke University Collection: Environmental...

203

E-Print Network 3.0 - anabolic bone hormone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

in the Absence of Weight Bearing Can Enhance Trabecular Summary: two orders of magnitude smaller than those previously sug- gested, can be anabolic to bone when... ....

204

E-Print Network 3.0 - age-related bone loss Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Medicine 2 Influence of the degradation of the organic matrix on the microscopic fracture behavior of trabecular bone Summary: . Modeling the mechanical behavior of vertebral...

205

E-Print Network 3.0 - animal bone collagen Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales Summary: of these cracks. 2005 Elsevier Ltd. All rights...

206

E-Print Network 3.0 - abnormally high bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by small intestine & promotes bone deposition... and Their Repairs stress fracture - break caused by abnormal ... Source: Morrell, Thomas E. - Department of Biology,...

207

E-Print Network 3.0 - affects bone parameters Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of bone quality will ultimately affect physical and morpho- logic parameters... fracture rates are most closely associated with ... Source: Rubin, Clinton T.- Department of...

208

E-Print Network 3.0 - absolutely normal bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

females (N 49). The data set consisted of bone biopsies from normal and vertebral fracture subjects... microradiographic studies of normal and oste- oporotic ... Source: Ecole...

209

E-Print Network 3.0 - anorganic bovine bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

interconnections in the nano-composite material bone: Fibrillar cross-links resist fracture on several length scales Summary: , Hobbs LW, Spector M. The ultrastructure of...

210

E-Print Network 3.0 - abdomen bone growth Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

factor I and bone... . Genetic strategies for elucidat- ing insulin-like ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

211

E-Print Network 3.0 - attenuates bone cancer-induced Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

is incorrectly classified as bone when forming the linear attenuation coefficient image. We then investigate two... of attenuation coefficients of water (represent- ing...

212

E-Print Network 3.0 - agonist attenuates bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

unbalanced bone turnover that has been associated with a decreased number of ... Source: Brand, Paul H. - Department of Physiology and Pharmacology, University of Toledo...

213

E-Print Network 3.0 - abnormal bone growth Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

@DIIT.UNICT.IT 1. INTRODUCTION Bone age assessment is a procedure frequently performed in pediatric radiology... . Based on a radiological examination of skeletal development of...

214

A study to optimize the macroscopic structure of bone pylons used in direct skeletal attachment systems  

E-Print Network [OSTI]

studies, the direct chemical bonding of a material to bone has also received attention. Hench, et. al. (1971), introduced a bone-bonding calcia-phosphosilicate glass ceramic and included a theoretical model, based on in-viva studies in rat femurs... bone tissue. In this study, ceramics composed of CaO and A1203 were implanted in young adult rhesus monkeys with favorable results. Greenlee, et. al. (1972), and Greenlee and Beckham (1972) studied bone ingrowth into glass ceramics and reported good...

Trono, Ruben

1975-01-01T23:59:59.000Z

215

E-Print Network 3.0 - animal bone biomechanics Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Sample search results for: animal bone biomechanics Page: << < 1 2 3 4 5 > >> 1 MECHANICAL AND AEROSPACE ENGINEERING COLLOQUIUM SERIES Summary: fluorescent markers of...

216

E-Print Network 3.0 - adult bone-marrow-derived mesenchymal Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

University of Washington at Seattle Collection: Biology and Medicine 34 Immobilized sonic hedgehog N-terminal signaling domain enhances differentiation of bone marrow-derived...

217

E-Print Network 3.0 - altered bone material Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

FRAMEWORKS FOR ENGINEERS Session 20.1 m: Musculoskeletal System -Bones Summary: architecture, and equally definite secondary alterations in their external confirmation" VI....

218

E-Print Network 3.0 - allowing normal bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Simulation Environment for Craniofacial Surgical Procedures Dan Morris1 Summary: the completion of the first loop. An additional bone modification tool allows the introduction...

219

E-Print Network 3.0 - affects trabecular bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

at different structural... bone, are ... Source: Gefen, Amit - Department of Biomedical Engineering, Tel Aviv University Collection: Engineering ; Biology and Medicine 2...

220

E-Print Network 3.0 - assess 3d bone Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Technologies and Information Sciences 2 Combining High-resolution Micro computed Tomography with Material Summary: : Quantification of connectivity in cancellous bone, with...

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

The effects of bisphenol A (BPA) exposure on fat mass and serum leptin concentrations have no impact on bone mineral densities in non-obese premenopausal women  

Science Journals Connector (OSTI)

Objectives Bisphenol A (BPA) exposure may promote obesity, but its effect on bone mineral density (BMD) has not been reported in humans. We aimed to examine the relationships between BPA exposure, body composition, serum estradiol, leptin, osteocalcin levels and \\{BMDs\\} in healthy premenopausal women. Design and methods In this cross-sectional study, a total of 246 healthy premenopausal women aged 20 years and older with regular menstrual cycles were investigated. Body mass index (BMI), fat mass, fat-free mass and \\{BMDs\\} were measured by DXA. Serum estradiol, leptin, osteocalcin, urinary BPA and \\{NTx\\} levels were also tested. Results Urinary BPA levels were positively associated with fat mass (r = 0.193, p = 0.006) and leptin (r = 0.236, p = 0.001) but not with fat-free mass after adjusting for age and BMI. BPA was not associated with serum estradiol levels, BMDs, or bone resorption marker \\{NTx\\} and bone formation parameter osteocalcin, either. A multivariate stepwise regression analysis confirmed that serum leptin levels were positively influenced by fat mass (? = 0.746, p BPA (? = 0.127, p = 0.01) but negatively correlated with fat-free mass (? = ? 0.196, p BPA exposure. Conclusions Although BPA exposure is related with increased amount of fat mass and elevated serum leptin levels, it has neutral effect on \\{BMDs\\} in premenopausal women, possibly due to the exclusive role of fat-free mass, which is unrelated to BPA in determining BMDs.

Hong-yan Zhao; Yu-fang Bi; Lin-ying Ma; Lin Zhao; Tian-ge Wang; Lian-zhen Zhang; Bei Tao; Li-hao Sun; Yong-ju Zhao; Wei-qing Wang; Xiao-yin Li; Man-yin Xu; Jia-lun Chen; Guang Ning; Jian-min Liu

2012-01-01T23:59:59.000Z

222

Long-Term Treatment with Eldecalcitol (1?, 25-Dihydroxy-2?- (3-hydroxypropyloxy) Vitamin D3) Suppresses Bone Turnover and Leads to Prevention of Bone Loss and Bone Fragility in Ovariectomized Rats  

Science Journals Connector (OSTI)

The purpose of this study is to estimate the efficacy of eldecalcitol (1?, 25-Dihydroxy-2?- (3-hydroxypropyloxy) vitamin D3; ELD) on bone metabolism after long-term administration. Six-month-old Wistar–Imamichi r...

Satoshi Takeda; Susan Y. Smith; Tatsuya Tamura…

2014-12-01T23:59:59.000Z

223

Effects of dietary silicon on bone characteristics of poultry  

E-Print Network [OSTI]

of the metal which they contain. Evidence indicates that silicon in the form of sodium meta-silicate (Na Si0 . 9H20) may be tied in with early bone calcification of weanling rats (Carlisle, 1970). The present study was designed to determine if additional..., demonstrated that many of the early workers on the distribution of silicon in the animal body reported values much too high. The amount of silicon reported in biological materials varies greatly; rats have approximately two percent silica in whole blood...

Plyler, James Edward

2012-06-07T23:59:59.000Z

224

AUTOMATION IN THE MEAT INDUSTRY | Cutting and Boning  

Science Journals Connector (OSTI)

Abstract The strongest incentives for the industry to adopt automation technology for cutting and boning relate to the drive for improved productivity through reduced labor. Also work environment, increased yield and adaptability to a wide range of customer specifications are important drivers. Automation in the pig meat industry has mainly been adopted in regions with high labor costs such as Northern Europe. In New Zealand the ovine meat industry has been progressive in developing and using automation technology. Automation in the beef industry is limited because of the complexity associated with handling of the size and biological variation of the material.

R. Clarke; J.U. Nielsen; N.T. Madsen

2014-01-01T23:59:59.000Z

225

Engineering tubular bone using mesenchymal stem cell sheets and coral particles  

SciTech Connect (OSTI)

Highlights: • We developed a novel engineering strategy to solve the limitations of bone grafts. • We fabricated tubular constructs using cell sheets and coral particles. • The composite constructs showed high radiological density and compressive strength. • These characteristics were similar to those of native bone. -- Abstract: The development of bone tissue engineering has provided new solutions for bone defects. However, the cell-scaffold-based approaches currently in use have several limitations, including low cell seeding rates and poor bone formation capacity. In the present study, we developed a novel strategy to engineer bone grafts using mesenchymal stem cell sheets and coral particles. Rabbit bone marrow mesenchymal stem cells were continuously cultured to form a cell sheet with osteogenic potential and coral particles were integrated into the sheet. The composite sheet was then wrapped around a cylindrical mandrel to fabricate a tubular construct. The resultant tubular construct was cultured in a spinner-flask bioreactor and subsequently implanted into a subcutaneous pocket in a nude mouse for assessment of its histological characteristics, radiological density and mechanical property. A similar construct assembled from a cell sheet alone acted as a control. In vitro observations demonstrated that the composite construct maintained its tubular shape, and exhibited higher radiological density, compressive strength and greater extracellular matrix deposition than did the control construct. In vivo experiments further revealed that new bone formed ectopically on the composite constructs, so that the 8-week explants of the composite sheets displayed radiological density similar to that of native bone. These results indicate that the strategy of using a combination of a cell sheet and coral particles has great potential for bone tissue engineering and repairing bone defects.

Geng, Wenxin [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China)] [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China); Ma, Dongyang [Department of Oral and Maxillofacial Surgery, Lanzhou General Hospital, Lanzhou Command of PLA, BinHe 333 South Road, Lanzhou 730052 (China)] [Department of Oral and Maxillofacial Surgery, Lanzhou General Hospital, Lanzhou Command of PLA, BinHe 333 South Road, Lanzhou 730052 (China); Yan, Xingrong; Liu, Liangqi; Cui, Jihong; Xie, Xin; Li, Hongmin [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China)] [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China); Chen, Fulin, E-mail: chenfl@nwu.edu.cn [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China)] [Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, No.229 North Taibai Road, Xi’an 710069 (China)

2013-04-19T23:59:59.000Z

226

Cortical Pitch Regions in Humans Respond Primarily to Resolved Harmonics and Are Located in Specific Tonotopic Regions of Anterior Auditory Cortex  

E-Print Network [OSTI]

Pitch is a defining perceptual property of many real-world sounds, including music and speech. Classically, theories of pitch perception have differentiated between temporal and spectral cues. These cues are rendered ...

Norman-Haignere, Samuel Victo

227

Human-machine interactions  

SciTech Connect (OSTI)

Digital technology utilizing a cognitive model based on human naturalistic decision-making processes, including pattern recognition and episodic memory, can reduce the dependency of human-machine interactions on the abilities of a human user and can enable a machine to more closely emulate human-like responses. Such a cognitive model can enable digital technology to use cognitive capacities fundamental to human-like communication and cooperation to interact with humans.

Forsythe, J. Chris (Sandia Park, NM); Xavier, Patrick G. (Albuquerque, NM); Abbott, Robert G. (Albuquerque, NM); Brannon, Nathan G. (Albuquerque, NM); Bernard, Michael L. (Tijeras, NM); Speed, Ann E. (Albuquerque, NM)

2009-04-28T23:59:59.000Z

228

Saccular hearing; turtle model for a human prosthesis  

Science Journals Connector (OSTI)

The saccule is a hearingorgan is some vertebrates thought to be responsive to substrate vibration (bone conduction) or low?frequency aerial sound. There was likely some overlap in these functions in the course of evolution after the sensory area to become the cochlea migrated from the saccule. That overlap is preserved in extant turtles by columella (stapes) saccular coupling via fibroelastic strands; thus both organs can respond to air conduction and bone conduction stimulation. Evoked potential data however reflect differential AC/BC drive to the inner ear. The columellas inertia provides the force to displace the saccular wall with the tympanum providing damping. Intense AC stimulation likely stimulates the human saccule. A proprietary stapedial saccular strut is described that serves as a surgically implanted coupling device for humans allowing more efficient use of AC saccular hearing in clinical deafness. The human saccular resonance is about 350 Hz which should allow for sufficient speech coding for intelligibility assuming connectivity to the auditory neuraxis. BC stimulation through audible ultrasound also likely activates the saccule in individuals with profound deafness. A stand?alone stapedio?saccular strut or one used in combination with an ultrasonichearing aid offers the potential of communication through saccular hearing.

2006-01-01T23:59:59.000Z

229

Impact of Omega-3 Polyunsaturated Fatty Acids on Bone Adaptations to Simulated Resistance Training  

E-Print Network [OSTI]

with arachidonic acid, an n-6 PUFA, for the cyclooxygenase enzyme, modulating prostaglandin E2, a mediator of bone mechanotransduction. Whether this diet affects bone gains during exercise is not well defined. We hypothesized rats consuming a high n-3 PUFA diet...

Camp, Kaleigh Ann

2013-04-30T23:59:59.000Z

230

Bone Surface Reconstruction From CT/MR Images Using Fast Marching and Level Set Methods1)  

E-Print Network [OSTI]

Bone Surface Reconstruction From CT/MR Images Using Fast Marching and Level Set Methods1) Istv surfaces reconstructed from MR volumes are shown. 1 Outline of the project One of our current projects steps of bone surface reconstruction from CT/MR slice images. 2 Main steps of reconstruction 2.1

Chetverikov, Dmitry

231

Dermal bone in early tetrapods: a palaeophysiological hypothesis of adaptation for terrestrial acidosis  

Science Journals Connector (OSTI)

...deposits in their endolymphatic lime sacs [39,40], and they...exchange of ions between the bone mineral matrix and the extracellular...no detectable effects on bone mineral content [46]. Thus, it remains...J. Irwin, and D. M. Green 2005 Thermal physiology and...

2012-01-01T23:59:59.000Z

232

Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing rats  

E-Print Network [OSTI]

Mineral bone composition and some elements of calcium metabolism in magnesium-deficient growing-Chomponelle, Theix, 63110 Beaumont, France. Summary. (1) Magnesium deficiency was induced in Sprague-Dawley male rats of deprivation. (3) The leg bones were fragmented as shown in figure 1. Their magnesium content had decreased

Paris-Sud XI, Université de

233

Biomimetic hydroxyapatite-containing composite nanofibrous substrates for bone tissue engineering  

Science Journals Connector (OSTI)

...concentration of calcium ions required to stimulate...osteoblasts for bone tissue engineering (figure-1 b). These...which favoured Ca2+ ion chelation. The alternative...concentrations of Ca and P ions up to a ratio of 1...proliferation for bone tissue engineering. 5. Conclusions This...

2010-01-01T23:59:59.000Z

234

Level of osteopenia and bone recovery in alcohol-fed adolescent rats  

E-Print Network [OSTI]

consumption on young, actively growing adolescent bones have not been done. The objective of this study was to determine the level of bone recovery, if any, once an adolescent ceases alcohol consumption. Fifty, 4-week old, female, Sprague-Dawley rats were...

Spears, Heather Lynae

2012-06-07T23:59:59.000Z

235

Long-lived Inflammatory Signaling in Irradiated Bone Marrow Is Genome Dependent  

Science Journals Connector (OSTI)

...reduction in colony-forming efficiency (CFE)]. In addition, the bone marrow of irradiated...humidified atmosphere of 5% CO2 in air (17). CFE was determined by the number of colonies...irradiated producer bone marrow cells and the CFE of CFU-A determined. The protocol is...

Sally A. Lorimore; Debayan Mukherjee; Joanne I. Robinson; Jennifer A. Chrystal; Eric G. Wright

2011-10-15T23:59:59.000Z

236

Quantitative analysis of radiological changes in alveolar bone around connected osseo-integrated dental implants and natural abutment teeth  

Science Journals Connector (OSTI)

To evaluate quantitatively the long-term changes in alveolar bone around toothimplant connections using a digital subtraction technique.

Akihiro Takashima DDS; Dr. Kazunori Yoshiura DDS; PhD; Kenji Tokumori…

2003-06-01T23:59:59.000Z

237

Single x-ray transmission system for bone mineral density determination  

SciTech Connect (OSTI)

Bones are the support of the body. They are composed of many inorganic compounds and other organic materials that all together can be used to determine the mineral density of the bones. The bone mineral density is a measure index that is widely used as an indicator of the health of the bone. A typical manner to evaluate the quality of the bone is a densitometry study; a dual x-ray absorptiometry system based study that has been widely used to assess the mineral density of some animals' bones. However, despite the success stories of utilizing these systems in many different applications, it is a very expensive method that requires frequent calibration processes to work properly. Moreover, its usage in small species applications (e.g., rodents) has not been quite demonstrated yet. Following this argument, it is suggested that there is a need for an instrument that would perform such a task in a more reliable and economical manner. Therefore, in this paper we explore the possibility to develop a new, affordable, and reliable single x-ray absorptiometry system. The method consists of utilizing a single x-ray source, an x-ray image sensor, and a computer platform that all together, as a whole, will allow us to calculate the mineral density of the bone. Utilizing an x-ray transmission theory modified through a version of the Lambert-Beer law equation, a law that expresses the relationship among the energy absorbed, the thickness, and the absorption coefficient of the sample at the x-rays wavelength to calculate the mineral density of the bone can be advantageous. Having determined the parameter equation that defines the ratio of the pixels in radiographies and the bone mineral density [measured in mass per unit of area (g/cm{sup 2})], we demonstrated the utility of our novel methodology by calculating the mineral density of Wistar rats' femur bones.

Jimenez-Mendoza, Daniel; Vargas-Vazquez, Damian [Division de Investigacion y Posgrado, Facultad de Ingenieria, Universidad Autonoma de Queretaro, Cerro de las Campanas s/n., C.P. 76010, Queretaro, Qro. (Mexico); Espinosa-Arbelaez, Diego G. [Posgrado en Ciencia e Ingenieria en Materiales, Instituto de Investigaciones en Materiales, Universidad Nacional Autonoma de Mexico, Av. Universidad 3000, C.P. 04510, Coyoacan, Mexico D.F. (Mexico); Departamento de Nanotecnologia, Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Boulevard Juriquilla 3001, C.P. 76230, A.P. 1-1010, Juriquilla, Qro. (Mexico); Giraldo-Betancur, Astrid L. [Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Libramiento Norponiente 2000, C.P. 76230, Fracc. Real de Juriquilla, Qro. (Mexico); Hernandez-Urbiola, Margarita I. [Posgrado en Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Boulevard Juriquilla 3001, C.P. 76230, A.P. 1-1010, Juriquilla, Qro. (Mexico); Departamento de Nanotecnologia, Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Boulevard Juriquilla 3001, C.P. 76230, A.P. 1-1010, Juriquilla, Qro. (Mexico); Rodriguez-Garcia, Mario E. [Departamento de Nanotecnologia, Centro de Fisica Aplicada y Tecnologia Avanzada, Universidad Nacional Autonoma de Mexico, Campus Juriquilla, Boulevard Juriquilla 3001, C.P. 76230, A.P. 1-1010, Juriquilla, Qro. (Mexico)

2011-12-15T23:59:59.000Z

238

Hierarchical interconnections in the nano-composite material Bone: Fibrillar Cross-Links resist fracture on several length scales  

E-Print Network [OSTI]

Hierarchical interconnections in the nano-composite material Bone: Fibrillar Cross-Links resist bone samples, possibly resisting the propagation of these cracks. Bone is one of the most important collagen and hydroxyapatite. Such materials are based on the crystal-polymer interactions on the molecular

Fygenson, Deborah Kuchnir

239

CCR5 Receptor Antagonists Block Metastasis to Bone of v-Src Oncogene–Transformed Metastatic Prostate Cancer Cell Lines  

Science Journals Connector (OSTI)

...capability of prostate cancer cells to bone and brain, with immediate clinical implications...cell lines metastasized in FVB mice to brain and bone. Gene expression profiling of...cultures. The whole body, bone, and brain metastatic prostate cancer burden was reduced...

Daniela Sicoli; Xuanmao Jiao; Xiaoming Ju; Marco Velasco-Velazquez; Adam Ertel; Sankar Addya; Zhiping Li; Sebastiano Andò; Alessandro Fatatis; Bishnuhari Paudyal; Massimo Cristofanilli; Mathew L. Thakur; Michael P. Lisanti; Richard G. Pestell

2014-12-01T23:59:59.000Z

240

Cognitive Science (Humanities)  

E-Print Network [OSTI]

Cognitive Science (Humanities) The University of Edinburgh College of Humanities and Social Science: Cognitive Science (Humanities) BSc Honours in: Cognitive Science Please see separate information sheets the disciplines that contribute to the study of human cognition. The Cognitive Science programme at Edinburgh

Schnaufer, Achim

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

Additively manufactured 3D porous Ti-6Al-4V constructs mimic trabecular bone structure and regulate osteoblast proliferation, differentiation and local factor production in a porosity and surface roughness dependent manner  

Science Journals Connector (OSTI)

Additive manufacturing by laser sintering is able to produce high resolution metal constructs for orthopedic and dental implants. In this study, we used a human trabecular bone template to design and manufacture Ti-6Al-4V constructs with varying porosity via laser sintering. Characterization of constructs revealed interconnected porosities ranging from 15–70% with compressive moduli of 2579–3693 MPa. These constructs with macro porosity were further surface-treated to create a desirable multi-scale micro-/nano-roughness, which has been shown to enhance the osseointegration process. Osteoblasts (MG63 cells) exhibited high viability when grown on the constructs. Proliferation (DNA) and alkaline phosphatase specific activity, an early differentiation marker, decreased as porosity increased, while osteocalcin, a late differentiation marker, as well as osteoprotegerin, vascular endothelial growth factor and bone morphogenetic proteins 2 and 4 increased with increasing porosity. Three-dimensional (3D) constructs with the highest porosity and surface modification supported the greatest osteoblast differentiation and local factor production. These results indicate that additively manufactured 3D porous constructs mimicking human trabecular bone and produced with additional surface treatment can be customized for increased osteoblast response. Increased factors for osteoblast maturation and differentiation on high porosity constructs suggest the enhanced performance of these surfaces for increasing osseointegration in vivo.

Alice Cheng; Aiza Humayun; David J Cohen; Barbara D Boyan; Zvi Schwartz

2014-01-01T23:59:59.000Z

242

An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma  

Science Journals Connector (OSTI)

...primers, PCR conditions, and exact positions of these markers have been described (Stanford Human Genome Center, http://shgc-www.stanford.edu.; Whitehead Institute for Biomedical Research/Massachusetts Institute of Technology Center for Genome...

Raul C. Ribeiro; Fabiano Sandrini; Bonald Figueiredo; Gerard P. Zambetti; Edson Michalkiewicz; Antony R. Lafferty; Luiz DeLacerda; Mark Rabin; Craig Cadwell; Gilberto Sampaio; Israil Cat; Constantine A. Stratakis; Romolo Sandrini

2001-01-01T23:59:59.000Z

243

Humanity’s unsustainable environmental footprint  

Science Journals Connector (OSTI)

...biodiversity loss or effects on human health or...billion m 3 /year (average for 1996 to 2005...billion m 3 /year (average for 1996 to...emissions from fossil fuels—part of humanity...products in their price—for example, by...The EF of the average global citizen...so-called rebound effect (44). Profound...

Arjen Y. Hoekstra; Thomas O. Wiedmann

2014-06-06T23:59:59.000Z

244

Geek-Up[6.10.2011]: Thermoelectrics' Great Power, Key Ingredient in Bone's  

Broader source: Energy.gov (indexed) [DOE]

10.2011]: Thermoelectrics' Great Power, Key Ingredient in 10.2011]: Thermoelectrics' Great Power, Key Ingredient in Bone's Nanostructure Geek-Up[6.10.2011]: Thermoelectrics' Great Power, Key Ingredient in Bone's Nanostructure June 10, 2011 - 5:07pm Addthis Data image on lead telluride thermal conductivity | Photo Courtesy of Oak Ridge National Laboratory Data image on lead telluride thermal conductivity | Photo Courtesy of Oak Ridge National Laboratory Niketa Kumar Niketa Kumar Public Affairs Specialist, Office of Public Affairs What does this mean for me? Identifying a key ingredient in bone's nanostructure may help treat and prevent bone diseases such as osteoporosis and develop new light-weight, high-strength materials for innovative technologies. Advanced thermoelectric materials could be used to develop vehicle

245

Bone Penetration of Amoxicillin and Clavulanic Acid Evaluated by Population Pharmacokinetics and Monte Carlo Simulation  

Science Journals Connector (OSTI)

...infusion. Simulations with our...equilibration by modeling and to derive...Monte Carlo simulations. Drusano...bone was rapid for both...using a fully automated extraction...pharmacokinetic modeling and Monte Carlo simulation. Antimicrob...

Cornelia B. Landersdorfer; Martina Kinzig; Jürgen B. Bulitta; Friedrich F. Hennig; Ulrike Holzgrabe; Fritz Sörgel; Johannes Gusinde

2009-03-23T23:59:59.000Z

246

E-Print Network 3.0 - arthritic bone loss Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Knee Arthroplasty in a Series of 48 Patients Summary: with the loss of thickness of polyethylene tibial bearings after knee arthroplasty. J Bone Joint Surg Am. 2007... -4 Optimal...

247

Circulating Rat Platelets in Lethally X-radiated Mice Given Rat Bone Marrow  

Science Journals Connector (OSTI)

...MAKINODAN,ANDC. C. CONGDON (Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennestee) By the use of immunohematological...given injections of rat bone marrow. These same workers also identified a distinctive chromo some in dividing...

L. H. Smith; T. Makinodan; and C. C. Congdon

1957-06-01T23:59:59.000Z

248

Clinical diagnostic indicators of renal and bone damage in rats intramuscularly injected with depleted uranium  

Science Journals Connector (OSTI)

......intramuscularly injected with depleted uranium S. Fukuda 1 M. Ikeda 1 M...related to kidney and bone in depleted uranium (DU)-injected rats were...injected is low. INTRODUCTION Depleted uranium (DU) accumulates like natural......

S. Fukuda; M. Ikeda; M. Chiba; K. Kaneko

2006-06-01T23:59:59.000Z

249

E-Print Network 3.0 - adult bone marrow-derived Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

32:69-77. 5. Garman R, Gaudette G, Donahue L, et al. 2007. Low... from bone marrow of young adult rats. Cell Tissue ... Source: You, Lidan - Department of Mechanical and...

250

8 - Bioactive glass and glass–ceramic foam scaffolds for bone tissue restoration  

Science Journals Connector (OSTI)

Abstract: One of the major goals of bone tissue engineering is the development of appropriate porous biomaterials (scaffolds) that can stimulate the body’s own regenerative mechanism, to induce tissue healing and self-repair. Bioactive glasses are excellent candidates for producing 3-D scaffolds, as their properties can be finely tailored depending on the glass composition, and they can bond to bone, inducing osteogenesis at the defect site. This chapter is focused on glass/glass–ceramic scaffolds characterized by foam-like architecture closely mimicking that of natural cancellous bone. After giving an overview of the features and limitations of the biomedical glass foams investigated in the literature, future directions of research will be described, emphasizing the challenge to develop multifunctional foams able to combine bone regeneration with special therapeutic functionalities.

F. Baino; C. Vitale-Brovarone

2014-01-01T23:59:59.000Z

251

Programming with human computation  

E-Print Network [OSTI]

Amazon's Mechanical Turk provides a programmatically accessible micro-task market, allowing a program to hire human workers. This has opened the door to a rich field of research in human computation where programs orchestrate ...

Little, Greg (Danny Greg)

2011-01-01T23:59:59.000Z

252

The Effects of Multiple Unloading Exposures on Bone Properties in the Femur of Adult Male Rats  

E-Print Network [OSTI]

to the National Osteoporosis Foundation, approximately 10 million people have the condition, with another 34 million currently at risk. It is estimated that half of all women over 50 and a quarter of all men will break a bone due to osteoporosis (10). Fractures....? During long term missions, such as to Mars, the astronauts may encounter situations where they could experience high impact forces relative to those experienced in transit. This, coupled with a potential reduction in bone strength due to microgravity...

Morgan, Derrick Scott

2012-07-16T23:59:59.000Z

253

Is humanity sustainable?  

Science Journals Connector (OSTI)

...size, CO2 production, energy use, biomass consumption...Humans| Is humanity sustainable? | The principles and...CO(2) production, energy use, biomass consumption...Resources Ecosystem Energy-Generating Resources...November 2003 Is humanity sustainable? Charles W. Fowler1...

2003-01-01T23:59:59.000Z

254

Human Functional Brain Imaging  

E-Print Network [OSTI]

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review #12;2 | Portfolio Review: Human Functional Brain ImagingThe Wellcome Trust is a charity registered in England and Wales, no's role in supporting human functional brain imaging and have informed `our' speculations for the future

Rambaut, Andrew

255

Biomedical Ethics & Medical Humanities  

E-Print Network [OSTI]

List Sample Elective Courses Arts & Humanities Medical Scholars: Student Projects #12;2 What is BEMHBEMH Biomedical Ethics & Medical Humanities Scholarly Concentration Stanford University School? The Biomedical Ethics and Medical Humanities Scholarly Concentration is part of the new initiative at Stanford

Ford, James

256

Human Genetics Portfolio Review  

E-Print Network [OSTI]

in providing the assessments of the Wellcome Trust's role in supporting human genetics and have informed `our to maximise the health benefits of research into the human genome remains a core component of the WellcomeHuman Genetics 1990­2009 June 2010 Portfolio Review #12;The Wellcome Trust is a charity registered

Rambaut, Andrew

257

Human Research ProgramHuman Research Program Human System Risk in Exploration and  

E-Print Network [OSTI]

Human System Risks in Exploration Missions 21SEP10 2HRP Risk Process ­ D.Grounds Presentation contentsHuman Research ProgramHuman Research Program Human System Risk in Exploration and the Human Research Program 21SEP10 1HRP Risk Process ­ D Grounds #12;Human Research ProgramHuman Research Program

Waliser, Duane E.

258

Dutch Human Geography  

Science Journals Connector (OSTI)

Human geography in the Dutch academia distinguishes itself from human geography in other continental European countries. It has developed a strong applied focus and an orientation which forms a bridge between continental European approaches in human Geography and the Anglo-Saxon human geography. The motor of this development has been the rivalry between the Amsterdam School of Sociography and the more French oriented Utrecht School of human geography. In recent times Dutch academic geography has found her way back from the more applied modes of thought to more theoretically informed debates, to which she contributes substantially.

H. Ernste; L. Smith

2009-01-01T23:59:59.000Z

259

ORISE: Human Subjects Protection  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Human Subjects Protection Human Subjects Protection The Oak Ridge Institute for Science and Education (ORISE) performs technical assessments to assist U.S. Department of Energy (DOE) laboratories involved in human subjects research projects. Under DOE Order and Policy 443.1A, Protection of Human Subjects, and 10 CFR 745, DOE employees and contractors are expected to protect the rights and welfare of human research subjects. In support of the DOE Office of Science and the Human Subjects Protection Program (HSPP), ORISE has most recently assisted with the development and distribution of tools to address classified research and to track potential human social cultural behavior systems (HSCB) research conducted by DOE laboratories. Examples of products that ORISE has developed in support of the HSPP

260

Effect of dietary calcium and phosphorus levels on performance and bone development of large-framed developing boars  

E-Print Network [OSTI]

quantitative carcass measurement among boars fed the six treatment diets. Bone breaking load (BKL) of the femurs increased quadratically (P&. 01) as mineral levels increased with a predicted maximum response at 1. 21X calcium and 1. 01X phosphorus. Breaking..., feed intake and feed efficiency for developing boars. However, higher dietary phosphorus levels were needed for maximum bone develop- ment. Maximum response was obtained from the following phosphorus levels: bone breaking load ranged from 1. 01X...

Robinson, Robert Glen

1975-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Biochemical Markers of Bone Turnover in Percutaneous Vertebroplasty for Osteoporotic Compression Fracture  

SciTech Connect (OSTI)

Purpose. To evaluate relationships between biochemical markers of bone turnover, bone mineral density, and new compression fractures following vertebroplasty. Methods. Initially, we enrolled 30 consecutive patients with vertebral compression fractures caused by osteoporosis. Twenty-three of the 30 patients visited our hospital for follow-up examinations for more than 4 weeks after vertebroplasty. The patients were divided into two groups: patients with new fractures (group F) and patients with no new fractures (group N). We analyzed differences in the following parameters between these two groups: serum bone alkaline phosphatase, urinary crosslinked N-telopeptide of type I collagen, urinary deoxypyridinoline, and bone mineral density. Next, the patients were divided into another two groups: patients with higher risk (group H: urinary crosslinked N-telopeptide of type I collagen >54.3 nmol BCE/mmol Cr or urinary deoxypyridinoline >7.6 nmol/mmol Cr, and serum bone alkaline phosphatase <29.0 U/l) and patients with lower risk (group L). We analyzed the difference in the rate of new fractures between these two groups. Results. We identified 9 new fractures in 7 patients. There were no significant differences between groups F and N. We identified 5 new fractures in 3 of the 4 patients in group H, and 4 new fractures in 4 of the 19 patients in group L. There was a significant difference in the rate of new fractures between groups H and L. Conclusions. A combination of high levels of bone resorption markers and normal levels of bone formation markers may be associated with increased risk of new recurrent fractures after percutaneous vertebroplasty.

Komemushi, Atsushi, E-mail: kome64@yo.rim.or.jp; Tanigawa, Noboru; Kariya, Shuji; Kojima, Hiroyuki; Shomura, Yuzo; Tokuda, Takanori; Nomura, Motoo; Terada, Jiro; Kamata, Minoru; Sawada, Satoshi [Kansai Medical University, Department of Radiology (Japan)

2008-03-15T23:59:59.000Z

262

Electron Microscopy and Analytical X-ray Characterization of Compositional and Nanoscale Structural Changes in Fossil Bone  

E-Print Network [OSTI]

on the identification of surviving collagen in bulk bonebulk regions of bone. This fact might prove exceptionally true if the identification

Boatman, Elizabeth

2012-01-01T23:59:59.000Z

263

Automated 3D trabecular bone structure analysis of the proximal femur—prediction of biomechanical strength by CT and DXA  

E-Print Network [OSTI]

z ORIGINAL ARTICLE Automated 3D trabecular bone structureIntroduction An automated 3D segmentation algorithm wasstudy was to use an automated 3D segmentation algorithm to

2010-01-01T23:59:59.000Z

264

Contact List, Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Human Resources & Occupational Medicine Division Human Resources & Occupational Medicine Division Contact List Human Resources Guest, User, Visitor (GUV) Center Occupational Medicine Training and Qualifications Office Note: All listed phone extensions are in the format of (631) 344-xxxx. Human Resources Robert Lincoln, Chief Human Resources Officer x7435 rlincoln@bnl.gov Margaret Hughes x2108 hughes@bnl.gov Elizabeth Gilbert x2315 gilbert@bnl.gov Human Resources Generalists Christel Colon, HR Manager - BES, GARS & ELS x8469 ccolon@bnl.gov Joann Williams, HR Manager - Support Operations x8356 williamsj@bnl.gov Joanna Hall, HR Manager - Photon Sciences x4410 jhall@bnl.gov Donna Dowling, HR Manager - Nuclear & Particle Physics x2754 dowling@bnl.gov Terrence Buck x8715 tbuck@bnl.gov

265

ORISE: Protecting Human Subjects  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

or performed by DOE employees, addresses the protection of human subjects. The Oak Ridge Institute for Science and Education (ORISE) supports DOE in its efforts to protect...

266

EMSL - human health  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

human-health en Physical Properties of Ambient and Laboratory-Generated Secondary Organic Aerosol. http:www.emsl.pnl.govemslwebpublicationsphysical-properties-ambient-and-labo...

267

Evaluation of dual energy quantitative CT for determining the spatial distributions of red marrow and bone for dosimetry in internal emitter radiation therapy  

SciTech Connect (OSTI)

Purpose: To evaluate a three-equation three-unknown dual-energy quantitative CT (DEQCT) technique for determining region specific variations in bone spongiosa composition for improved red marrow dose estimation in radionuclide therapy. Methods: The DEQCT method was applied to 80/140 kVp images of patient-simulating lumbar sectional body phantoms of three sizes (small, medium, and large). External calibration rods of bone, red marrow, and fat-simulating materials were placed beneath the body phantoms. Similar internal calibration inserts were placed at vertebral locations within the body phantoms. Six test inserts of known volume fractions of bone, fat, and red marrow were also scanned. External-to-internal calibration correction factors were derived. The effects of body phantom size, radiation dose, spongiosa region segmentation granularity [single (?17 × 17 mm) region of interest (ROI), 2 × 2, and 3 × 3 segmentation of that single ROI], and calibration method on the accuracy of the calculated volume fractions of red marrow (cellularity) and trabecular bone were evaluated. Results: For standard low dose DEQCT x-ray technique factors and the internal calibration method, the RMS errors of the estimated volume fractions of red marrow of the test inserts were 1.2–1.3 times greater in the medium body than in the small body phantom and 1.3–1.5 times greater in the large body than in the small body phantom. RMS errors of the calculated volume fractions of red marrow within 2 × 2 segmented subregions of the ROIs were 1.6–1.9 times greater than for no segmentation, and RMS errors for 3 × 3 segmented subregions were 2.3–2.7 times greater than those for no segmentation. Increasing the dose by a factor of 2 reduced the RMS errors of all constituent volume fractions by an average factor of 1.40 ± 0.29 for all segmentation schemes and body phantom sizes; increasing the dose by a factor of 4 reduced those RMS errors by an average factor of 1.71 ± 0.25. Results for external calibrations exhibited much larger RMS errors than size matched internal calibration. Use of an average body size external-to-internal calibration correction factor reduced the errors to closer to those for internal calibration. RMS errors of less than 30% or about 0.01 for the bone and 0.1 for the red marrow volume fractions would likely be satisfactory for human studies. Such accuracies were achieved for 3 × 3 segmentation of 5 mm slice images for: (a) internal calibration with 4 times dose for all size body phantoms, (b) internal calibration with 2 times dose for the small and medium size body phantoms, and (c) corrected external calibration with 4 times dose and all size body phantoms. Conclusions: Phantom studies are promising and demonstrate the potential to use dual energy quantitative CT to estimate the spatial distributions of red marrow and bone within the vertebral spongiosa.

Goodsitt, Mitchell M., E-mail: goodsitt@umich.edu; Shenoy, Apeksha; Howard, David; Christodoulou, Emmanuel; Dewaraja, Yuni K. [Department of Radiology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States)] [Department of Radiology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States); Shen, Jincheng [Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, Michigan 48109 (United States)] [Department of Biostatistics, University of Michigan, 1415 Washington Heights, Ann Arbor, Michigan 48109 (United States); Schipper, Matthew J. [Department of Radiation Oncology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States)] [Department of Radiation Oncology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States); Wilderman, Scott [Department of Nuclear Engineering, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States)] [Department of Nuclear Engineering, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 (United States); Chun, Se Young [Ulsan National Institute of Science and Technology (UNIST), School of Electrical and Computer Engineering, Ulsan 689-798 (Korea, Republic of)] [Ulsan National Institute of Science and Technology (UNIST), School of Electrical and Computer Engineering, Ulsan 689-798 (Korea, Republic of)

2014-05-15T23:59:59.000Z

268

Transient temperature rise due to ultrasound absorption at a bone/soft-tissue interface  

Science Journals Connector (OSTI)

Thermal effects due to high ultrasound absorption in bone pose an ongoing safety issue. Of considerable concern is the heating of the soft tissue adjacent to the bone surface. Mathematical models can be useful in predicting the transient temperature near the interface during insonation. This paper develops a model that provides the temperature field in terms of simple expressions that convey the functional dependence of the material properties and are easily incorporated into standards and ultrasound machine software yet are able to incorporate the material properties of both bone and soft tissue. The model contains an asymptotic theory based upon a “high-attenuation” assumption: the distance diffused by heat over the time of interest is large compared to the ultrasound attenuation length. Model predictions of temperature rise and location of maximum temperature were in close agreement with finite-element calculations using parameters appropriate for radiation-force imaging and focused-ultrasound surgery.

Matthew R. Myers

2004-01-01T23:59:59.000Z

269

Science and Human Values  

Science Journals Connector (OSTI)

... THE three essays on "Science and Human A Values" which Dr. J. Bronowski has contributed to recent issues ... Dr. Bronowski discusses the sense of human dignity and challenges widely held views of what science is and does. These views are highly relevant to the current task of developing- ...

1957-02-02T23:59:59.000Z

270

integration division Human Systems  

E-Print Network [OSTI]

Vibration Test Facility incorporates state-of-the-art vibration generation and measurement hardwareintegration division Human Systems ISIS Vibration Test Facility Objective Approach Impact 1. Assess impact of flight-like whole-body vibration on human operational capabilities and ability to maintain

271

STUDENT EMPLOYMENT HUMAN RESOURCES  

E-Print Network [OSTI]

STUDENT EMPLOYMENT HUMAN RESOURCES GUIDELINE Human Resources | One Washington Square | San José, CA 95192-0046 | 408-924-2250 408-924-2284 (fax) SUBJECT: STUDENT EMPLOYMENT DATE: March 2007 I. PURPOSE / DESCRIPTION Student employees are defined as matriculated students that work part-time in any

Gleixner, Stacy

272

Human Functional Brain Imaging  

E-Print Network [OSTI]

Human Functional Brain Imaging 1990­2009 September 2011 Portfolio Review Summary Brain Imaging #12 Dale ­ one of our first Trustees. Understanding the brain remains one of our key strategic aims today three-fold: · to identify the key landmarks and influences on the human functional brain imaging

Rambaut, Andrew

273

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects; and in DOE P 443.1A, Protection of Human Subjects, dated 12-20-07. Cancels DOE O 443.1. Canceled by DOE O 443.1B.

2007-12-20T23:59:59.000Z

274

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

To establish DOE procedures and responsibilities for implementing the policy and requirements set forth in 10 CFR Part 745, Protection of Human Subjects, ad in DOE P 443.1, Policy on the Protection of Human Subjects. Cancels DOE O 1300.3. Canceled by DOE O 443.1A.

2000-05-15T23:59:59.000Z

275

Thermodynamics and Humanism  

Science Journals Connector (OSTI)

... chapter, his intention appears to have been to write on the wider human aspects of thermodynamics, to contribute to scientific humanism, which he defines as the unification of the specialized ... body of the book is, however, a fairly straightforward explanation of the laws of thermodynamics, partly classical and partly statistical, which will undoubtedly be helpful to students of the ...

J. A. V. BUTLER

1947-07-19T23:59:59.000Z

276

Genomics of human longevity  

Science Journals Connector (OSTI)

...the original work is properly cited. Genomics of human longevity P. E. Slagboom 1...progress. human longevity|longevity genomics|epigenetics and ageing| 1. Introduction...Innovation Oriented Research Programme on Genomics (SenterNovem; IGE01014 and IGE5007...

2011-01-01T23:59:59.000Z

277

Humans and Gills  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Humans and Gills Humans and Gills Name: Shelley Location: N/A Country: N/A Date: N/A Question: Is it true that some babies are born with some sort of gills? How and when do humans adapt from breathing inside to breathing outside of the womb? Replies: Whoa! You have received a great deal of false information. First, babies are not born with gills! Get that out of your thinking! Babies do not "breath" for oxygen in the womb. They do "practice breathing" using the amniotic fluid of the womb, but it is not doing them any good otherwise. All of the embryo and fetal needs are received through the placenta. The mother provides everything that is needed. As for the gills, there is a stage in the early human embryo development whereby humans do show gill slits, but not functional gills. Slits are not gills!! As a matter of fact, all vertebrates show these same gill slits.

278

Effects of Monoclonal Antibody and Complement Treatment of Human Marrow on Hematopoiesis in Continuous Bone Marrow Culture  

Science Journals Connector (OSTI)

...conjugate of three monoclonalantibodies. Science(Wash. DC),222: 512-515, 1983. 51. Vand de Wijngaert, F. P., and Rademakers, L. H. P. M., Schuurman, H-J., deWeger, R. A., and Kater, L. Identification and in situ localization of the...

Joel S. Greenberger; Lisa Rothstein; Paolo DeFabritiis; Marco Bregni; Robert Bast, Jr.; Jerome Ritz; Lee M. Nadler; Jeffrey M. Lipton; Mary Ann Sakakeeny

1985-02-01T23:59:59.000Z

279

The inverse agonist effect of rimonabant on G protein activation is not mediated by the cannabinoid CB1 receptor: Evidence from postmortem human brain  

Science Journals Connector (OSTI)

Rimonabant (SR141716) was the first potent and selective cannabinoid CB1 receptor antagonist synthesized. Several data support that rimonabant behaves as an inverse agonist. Moreover, there is evidence suggesting that this inverse agonism may be CB1 receptor-independent. The aim of the present study was to elucidate whether the effect of rimonabant over G protein activation in postmortem human brain is CB1 dependent or independent. [35S]GTP?S binding assays and antibody-capture [35S]GTP?S scintillation proximity assays (SPA) were performed in human and mice brain. [3H]SR141716 binding characteristics were also studied. Rimonabant concentration-dependently decreased basal [35S]GTP?S binding to human cortical membranes. This effect did not change in the presence of either the CB1 receptor agonist WIN 55,212-2, the CB1 receptor neutral antagonist O-2050, or the CB1 allosteric modulator Org 27569. [35S]GTP?S binding assays performed in CB1 knockout mice brains revealed that rimonabant inhibited the [35S]GTP?S binding in the same manner as it did in wild-type mice. The SPA combined with the use of specific antibody-capture of G? specific subunits showed that rimonabant produces its inverse agonist effect through Gi3, Go and Gz subtypes. This effect was not inhibited by the CB1 receptor antagonist O-2050. Finally, [3H]SR141716 binding assays in human cortical membranes demonstrated that rimonabant recognizes an additional binding site other than the CB1 receptor orthosteric binding site recognized by O-2050. This study provides new data demonstrating that at least the inverse agonist effect observed with >1 ?M concentrations of rimonabant in [35S]GTP?S binding assays is not mediated by the CB1 receptor in human brain.

A.M. Erdozain; R. Diez-Alarcia; J.J. Meana; L.F. Callado

2012-01-01T23:59:59.000Z

280

A parametric analysis of bone fixation plates on fractured equine third metacarpal  

E-Print Network [OSTI]

A P~TRIC ANALYSIS OI' BONE FIXATION PLATES ON FRACTURED EQUINE THIRD lKTACARPAL A Thesis by Donald Reagan Ray Submitted to tnk Graduate College of Texas A&N University in partial fulfillment of the requirement for the degree of MASTER... OF SCIENCE Hay 1970 Major Subject: Civil Engineering A PARAMETRIC ANALYSIS OF BONE FIXATION PLATES ON FRACTURED EQUINE THIRD METACARPAL A Thesis Donald Reagan Ray Approved as to style and content by: (Cha of Committee) / I (Head of D artment...

Ray, Donald Reagan

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

Higher doses of bisphosphonates further improve bone mass, architecture, and strength but not the tissue material properties in aged rats  

E-Print Network [OSTI]

but not the tissue material properties in aged rats Mohammad Shahnazari a , Wei Yao a , WeiWei Dai a , Bob Wang in aged osteopenic rats to explain how bone material and bone mass may be affected by the dose of bisphosphonates (BP) and contribute to their anti- fracture efficacy. Eighteen-month old female rats underwent

Ritchie, Robert

282

Mechanical interaction between cells and fluid for bone tissue engineering scaffold: Modulation of the interfacial shear stress  

E-Print Network [OSTI]

Mechanical interaction between cells and fluid for bone tissue engineering scaffold: Modulation Analytical solution Bone tissue engineering a b s t r a c t An analytical model of the fluid/cell mechanical n f o Article history: Accepted 1 November 2009 Keywords: Cell fluid interaction Shear stress

Guerraoui, Rachid

283

The effects of vibration loading on adipose stem cell number, viability and differentiation towards bone-forming cells  

Science Journals Connector (OSTI)

...used in clinical bone tissue engineering [33,34]. Vibration stimuli...of ASC-based bone tissue engineering constructs. As recent findings...and built at the Biomedical Engineering Department, Tampere University...amplified by a T.AMP E800 audio amplifier (Musikhaus Thomann...

2011-01-01T23:59:59.000Z

284

Division of Human Resources Human Resources / Attendance and Leave Philosophy  

E-Print Network [OSTI]

Division of Human Resources PHILOSOPHY Human Resources / Attendance and Leave Philosophy Form Leave Act (FMLA). USF augments these provisions with local processes and philosophies and, in some cases

Meyers, Steven D.

285

Special Issue on Human Computing  

E-Print Network [OSTI]

The seven articles in this special issue focus on human computing. Most focus on two challenging issues in human computing, namely, machine analysis of human behavior in group interactions and context-sensitive modeling.

Nijholt, Anton

286

The human genome project  

SciTech Connect (OSTI)

The Human Genome Project will obtain high-resolution genetic and physical maps of each human chromosome and, somewhat later, of the complete nucleotide sequence of the deoxyribonucleic acid (DNA) in a human cell. The talk will begin with an extended introduction to explain the Project to nonbiologists and to show that map construction and sequence determination require extensive computation in order to determine the correct order of the mapped entities and to provide estimates of uncertainty. Computational analysis of the sequence data will become an increasingly important part of the project, and some computational challenges are described. 5 refs.

Bell, G.I.

1991-06-01T23:59:59.000Z

287

Parahippocampal and retrosplenial contributions to human spatial  

E-Print Network [OSTI]

navigational tasks and also during passive viewing of navigationally relevant stimuli such as environmental parahippocampal and retro- splenial cortices [4­10], regions that also respond strongly during passive viewing' or `house' area [13,14,22], its response to buildings is smaller than the response to scenes [11

Epstein, Russell A.

288

ALSNews Vol. 311  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1 Print 1 Print Irradiation Effects on Human Cortical Bone Fracture Behavior The role irradiation plays in high-exposure bone fracturing experiments, and how it affects the properties of bone tissue, are not fully understood. To better predict fracturing in bone, researchers must understand the role of sustained irradiation damage at different size scales within bone. Using synchrotron radiation microtomography at ALS Beamline 8.3.2, researchers investigated changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that this can lead to drastic losses in strength, ductility, and toughness. Read more... Contact: Robert O. Ritchie Investigating Extreme Ultraviolet Lithography Mask Defects Printing computer chips using extreme ultraviolet (EUV) lithography will enable the production of smaller, faster, and cheaper semiconductors. EUV lithography relies on specialized, curved-mirror lenses to print patterns with high resolution. One special flat mirror called a mask is particularly sensitive to even the smallest imperfections. To better detect and characterize mask defects, Berkeley Lab scientists worked with an international semiconductor industry consortium to create a unique Fresnel zoneplate microscope on ALS Beamline 11.3.2: The SEMATECH Berkeley Actinic Inspection Tool (AIT). Read more...

289

ALSNews Vol. 311  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1 Print 1 Print Irradiation Effects on Human Cortical Bone Fracture Behavior The role irradiation plays in high-exposure bone fracturing experiments, and how it affects the properties of bone tissue, are not fully understood. To better predict fracturing in bone, researchers must understand the role of sustained irradiation damage at different size scales within bone. Using synchrotron radiation microtomography at ALS Beamline 8.3.2, researchers investigated changes in crack path and toughening mechanisms in human cortical bone with increased exposure to radiation, finding that this can lead to drastic losses in strength, ductility, and toughness. Read more... Contact: Robert O. Ritchie Investigating Extreme Ultraviolet Lithography Mask Defects Printing computer chips using extreme ultraviolet (EUV) lithography will enable the production of smaller, faster, and cheaper semiconductors. EUV lithography relies on specialized, curved-mirror lenses to print patterns with high resolution. One special flat mirror called a mask is particularly sensitive to even the smallest imperfections. To better detect and characterize mask defects, Berkeley Lab scientists worked with an international semiconductor industry consortium to create a unique Fresnel zoneplate microscope on ALS Beamline 11.3.2: The SEMATECH Berkeley Actinic Inspection Tool (AIT). Read more...

290

Spontaneous Human Combustion  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Spontaneous Human Combustion Spontaneous Human Combustion Name: S. Phillips. Age: N/A Location: N/A Country: N/A Date: N/A Question: One of our 8th grade students has tried to find information in our library about spontaneous human combustion, but to no avail. Could you tell us where we might locate a simple reference, or provide some in information about this subject for him. Replies: Sorry, but this is definitely "fringe science"...try asking in bookstores. I seem to recall one of those "believe it or not" type of TV shows did an episode on spontaneous human combustion a few years ago in which they reported on some British scientists who investigated this purported phenomenon. Remember that people (back in the Dark Ages, and before) used to believe in "spontaneous generation" of certain plants and animals because they were not aware of the reproduction methods used by those plants and animals.

291

TEMPORARY SUPPORT HUMAN RESOURCES  

E-Print Network [OSTI]

TEMPORARY SUPPORT HUMAN RESOURCES GUIDELINE Workforce Planning | One Washington Square | San José of the Request for Temporary Support, Workforce Planning will make a determination of the type of temporary

Su, Xiao

292

Human intelligible positioning  

E-Print Network [OSTI]

We use street addresses to refer to locations in a city. Street addresses are easy to remember and communicate because they follow a symbolic addressing scheme, containing human intelligible symbols. However, street addresses ...

Venugopalan, Vishwanath, 1981-

2004-01-01T23:59:59.000Z

293

KRFTWRK – Global Human Electricity  

E-Print Network [OSTI]

Power Network 2.1.1 Virtual Power Plants The Global Powernetwork, based on "Virtual Power Plants", called "VPP". A "participant runs a virtual human power plant. Per every "

Prohaska, Rainer

2009-01-01T23:59:59.000Z

294

Human Reliability Program Overview  

SciTech Connect (OSTI)

This presentation covers the high points of the Human Reliability Program, including certification/decertification, critical positions, due process, organizational structure, program components, personnel security, an overview of the US DOE reliability program, retirees and academia, and security program integration.

Bodin, Michael

2012-09-25T23:59:59.000Z

295

Humans Need Biodiversity  

Science Journals Connector (OSTI)

...economic, and environmental policies—the three pillars of sustainability practice—to manage natural resource...bright light on the tight connections between sustainability practices and human survival could make conservation...

David P. Mindell

2009-03-20T23:59:59.000Z

296

Human Resource Management Delegation  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The notice is to clarifies and updates existing Human Resource Management Delegation Authorities and the levels to which they are delegated. Expired 6-28-97. Does not cancel any directives.

1996-06-28T23:59:59.000Z

297

Human Resources & Rebecca Leinen  

E-Print Network [OSTI]

Human Resources & Training Rebecca Leinen SafetyInformation Systems Chris Smeds Work Management Mark Webb Energy & Utilities Cheryl Gomez Operations & Maintenance Cheryl Gomez, interim Systems Services Delta Force Recycling Sustainability Outreach Office for Sustainability Utility Systems Power

Acton, Scott

298

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The purpose of this Policy is to establish DOE-specific policy for the protection of human subjects involved in DOE research. Canceled by DOE P 443.1A.

2000-05-15T23:59:59.000Z

299

Protection of Human Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The Policy is to establish DOE-specific principles for the protection of human subjects involved in DOE research. Cancels DOE P 443.1. Canceled by DOE O 443.1B

2007-12-20T23:59:59.000Z

300

School of Architecture, Design and the Built Environment Project Title: Artificial bone for prosthetic hip joints  

E-Print Network [OSTI]

formation by the Additive Manufacturing (AM) direct printing process. The artificial bone must and the development of new additive manufacturing techniques for medical devices. The group has active links and structural gradients into the prosthesis. It is envisioned this could involve the use of additively

Evans, Paul

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Methods for identifying cancellous bone specimen location and size for the Reduced Platen Compression Test  

E-Print Network [OSTI]

method for defining the specimen thickness is to average the largest and smallest overall bone lengths in the test group and use a reference thickness of 2 millimeters as a percentage of this average length. This percentage of the overall average length...

Cowen, Kyle Ray

2013-02-22T23:59:59.000Z

302

USE OF CdTe DETECTORS IN BONE MINERAL MEASUREMENTS J. VOGEL, J. ULLMAN  

E-Print Network [OSTI]

375 USE OF CdTe DETECTORS IN BONE MINERAL MEASUREMENTS J. VOGEL, J. ULLMAN Nuclear Medicine. Cet ensemble emploie des détecteurs CdTe mesurant la transmission d'un faisceau collimaté de rayons X periods of prolonged bedrest or weightlessness. The unit employs CdTe detectors to mea- sure

Paris-Sud XI, Université de

303

Characterization of Bone Metastases from Rapid Autopsies of Prostate Cancer Patients  

Science Journals Connector (OSTI)

...as tumor tissues are lodged in the calcified, dense bone infrastructure. Investigation of metastatic prostate cancer at the phenotypic...FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts.Blood 1998;92:3025-34. 19. Pampalakis...

Rohit Mehra; Chandan Kumar-Sinha; Sunita Shankar; Robert J. Lonigro; Xiaojun Jing; Neena E. Philips; Javed Siddiqui; Bo Han; Xuhong Cao; David C. Smith; Rajal B. Shah; Arul M. Chinnaiyan; and Kenneth J. Pienta

2011-06-15T23:59:59.000Z

304

From a Dry Bone to a Genetic Portrait: A Case Study of Sickle Cell Anemia  

E-Print Network [OSTI]

From a Dry Bone to a Genetic Portrait: A Case Study of Sickle Cell Anemia MARINA FAERMAN,1* ALMUT identification; Y chromosome polymorphic markers; sickle cell anemia ABSTRACT The potential and reliability sample, which represented a documented case of sickle cell anemia. -globin gene sequences obtained from

305

Radiocarbon Dating of Petroleum-Impregnated Bone from Tar Pits at Rancho La Brea, California  

Science Journals Connector (OSTI)

...Angeles County Museum for Natural History. These bones are...deviation (9). Analysis by gas chromatography of hexane...miles (48 km) south of Corpus Christi, Texas. The core from...yields a sample suitable for gas-chro-matographic analysis...

T. Y. Ho; Leslie F. Marcus; Rainer Berger

1969-05-30T23:59:59.000Z

306

Mechanical regulation of signaling pathways in bone, William R. Thompson a,  

E-Print Network [OSTI]

Review Mechanical regulation of signaling pathways in bone, William R. Thompson a, , Clinton T A wide range of cell types depend on mechanically induced signals to enable appropriate physiological re- sponses. The skeleton is particularly dependent on mechanical information to guide the resident cell

307

Nano-mechanical properties of individual mineralized collagen fibrils from bone tissue  

Science Journals Connector (OSTI)

...research-article Research articles 1004 25 27 131 Nano-mechanical properties of individual mineralized...phenomenological model is used to describe the fibril nano-mechanical behaviour. biomechanics...materials. Bone is structurally a composite as nano-fibres of CFs act as a template for the...

2011-01-01T23:59:59.000Z

308

Stability and Three-Dimensional Analysis of Bone Formation in Longitudinally Fluted Miniscrew Implants  

E-Print Network [OSTI]

The purpose of the present study is to evaluate the effects of longitudinal flutes on mini-screw implant (MSI) bone healing and stability. Using 11 skeletally mature New Zealand White rabbits, 33 longitudinally fluted and 33 non-fluted MSIs were...

Truong, An Van

2014-04-22T23:59:59.000Z

309

Hear-Through and Mic-Through Augmented Reality: Using Bone Conduction to Display Spatialized Audio  

E-Print Network [OSTI]

Hear-Through and Mic-Through Augmented Reality: Using Bone Conduction to Display Spatialized Audio-generated audio for augmented reality (AR) applications. Analogous to optical-see-through and video-see-through techniques in the visual domain, we present Hear-Through and Mic-Through audio AR. Hear-Through AR uses

Lindeman, Robert W.

310

Human Factors Review Plan  

SciTech Connect (OSTI)

''Human Factors'' is concerned with the incorporation of human user considerations into a system in order to maximize human reliability and reduce errors. This Review Plan is intended to assist in the assessment of human factors conditions in existing DOE facilities. In addition to specifying assessment methodologies, the plan describes techniques for improving conditions which are found to not adequately support reliable human performance. The following topics are addressed: (1) selection of areas for review describes techniques for needs assessment to assist in selecting and prioritizing areas for review; (2) human factors engineering review is concerned with optimizing the interfaces between people and equipment and people and their work environment; (3) procedures review evaluates completeness and accuracy of procedures, as well as their usability and management; (4) organizational interface review is concerned with communication and coordination between all levels of an organization; and (5) training review evaluates training program criteria such as those involving: trainee selection, qualification of training staff, content and conduct of training, requalification training, and program management.

Paramore, B.; Peterson, L.R. (eds.)

1985-12-01T23:59:59.000Z

311

Fisetin antagonizes cell fusion, cytoskeletal organization and bone resorption in RANKL-differentiated murine macrophages  

Science Journals Connector (OSTI)

Abstract Osteoclastogenesis is comprised of several stage s including progenitor survival, differentiation to mononuclear preosteoclasts, cell fusion to multinuclear mature osteoclasts, and activation to osteoclasts with bone resorbing activity. Botanical antioxidants are now being increasingly investigated for their health-promoting effects on bone. This study investigated that fisetin, a flavonol found naturally in many fruits and vegetables, suppressed osteoclastogenesis by disturbing receptor activator of nuclear factor (NF)-?B ligand (RANKL)-mediated signaling pathway and demoting osteoclastogenic protein induction. Nontoxic fisetin at ?10?M inhibited the induction of RANK, tumor necrosis factor receptor associated factor 6 (TRAF6) and the activation of NF-?B in RANKL-stimulated RAW 264.7 macrophages. In RANKL-differentiated osteoclasts cell fusion protein of E-cadherin was induced, which was dampened by fisetin. The formation of tartrate-resistance acid phosphatase-positive multinucleated osteoclasts was suppressed by adding fisetin to RANKL-exposed macrophages. It was also found that fisetin reduced actin ring formation and gelsolin induction of osteclasts enhanced by RANKL through disturbing c-Src-proline-rich tyrosine kinase 2 signaling. Fisetin deterred preosteoclasts from the cell-cell fusion and the organization of the cytoskeleton to seal the resorbing area and to secret protons for bone resorption. Consistently, the 5 day-treatment of fisetin diminished RANKL-induced cellular expression of carbonic anhydrase II and integrin ?3 concurrently with a reduction of osteoclast bone-resorbing activity. Therefore, fisetin was a natural therapeutic agent retarding osteoclast fusion and cytoskeletal organization such as actin rings and ruffled boarder, which is a property of mature osteoclasts and is required for osteoclasts to resorb bone.

Yun-Ho Kim; Jung-Lye Kim; Eun-Jung Lee; Sin-Hye Park; Seon-Young Han; Soon Ah Kang; Young-Hee Kang

2014-01-01T23:59:59.000Z

312

The Human Genome From human genome to other  

E-Print Network [OSTI]

genome to health Structural Genomics initiative #12;What is the Human Genome Project? · U.S. govtThe Human Genome Project From human genome to other genomes and to gene function June 2000 From that arise from genome research #12;The Human Genome Project Project began in 1990 as a $3 billion, 15-year

Linial, Michal

313

Time, Humans and Societal Challenges  

E-Print Network [OSTI]

,000 (human development) Since 1850 (industrial revolution Since 1950 (population explosion) Sustainable

314

The estimation of radiation doses in human organs due to natural and artificial radioactivity in surface waters of the Ebro river basin (Northeast Spain)  

Science Journals Connector (OSTI)

This paper reports the estimation of the radiation doses in the human body in the Ebro river basin (Northeast Spain), following drinking water ingestion by measuring 40K, 226Ra, 90Sr and 3H. The equivalent dose in ten different organs was estimated. Dose calculations were performed by means of the GENII computer program. The lowest equivalent dose calculated through ingesting drinking water was in the small intestine whereas the highest was in the bone surface.

Feda Oner; Nazmi T. Okumusoglu

2006-01-01T23:59:59.000Z

315

Human hybrid hybridoma  

SciTech Connect (OSTI)

Hybrid hybridomas are obtained by fusion of two cells, each producing its own antibody. Several authors have reported the construction of murine hybrid hybridomas with the aim to obtain bispecific monoclonal antibodies. The authors have investigated, in a model system, the feasibility of constructing a human hybrid hybridoma. They fused two monoclonal cell lines: an ouabain-sensitive and azaserine/hypoxanthine-resistant Epstein-Barr virus-transformed human cell line that produces an IgG1kappa antibody directed against tetanus toxiod and an azaserine/hypoxanthine-sensitive and ouabain-resistant human-mouse xenohybrid cell line that produces a human IgG1lambda antibody directed against hepatitis-B surface antigen. Hybrid hybridoma cells were selected in culture medium containing azaserine/hypoxanthine and ouabain. The hybrid nature of the secreted antibodies was analyzed by means of two antigen-specific immunoassay. The results show that it is possible, with the combined use of transformation and xenohybridization techniques, to construct human hybrid hybridomas that produce bispecific antibodies. Bispecific antibodies activity was measured by means of two radioimmunoassays.

Tiebout, R.F.; van Boxtel-Oosterhof, F.; Stricker, E.A.M.; Zeijlemaker, W.P.

1987-11-15T23:59:59.000Z

316

Relocation Guide, Human Resources  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Relocation Information Guide Relocation Information Guide The Human Resources Division is providing this Information Guide to you to help ease the transition of relocating to Long Island. Relocating to a new place can be an exciting as well as stressful time. We have compiled information that can be very helpful with the many issues you may face. You may also seek assistance from the recruiter you work with in Human Resources. Service Disclaimer - This web page contains links to other Internet sites. These links are not endorsements of any products or services and no information in such site has been endorsed or approved by Brookhaven National Laboratory or the Human Resources Division. Here are some of the issues: Cost of living Buying or renting a home Schools in the area

317

Turkey vs. human digestion  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Turkey vs. human digestion Turkey vs. human digestion Name: wallyb Location: N/A Country: N/A Date: N/A Question: How is the digestive system of turkeys different from that of humans? Replies: Hmmm.. been a while since I had sophomore biology, so I can't completely answer this one, but I can say a few things. One, since turkeys are birds, and birds as a general rule have not had teeth for several million years at least, the turkey needs a way to mash up its food -- thus, the crop, which is essentially like another stomach: the turkey (and many other birds, for that matter) swallows small stones which serve in lieu of teeth, mashing up food via muscular action in the crop, from whence the "chewed" food moves on into the rest of the digestive tract. As for any other differences, I'll have to leave that to someone else with more ornithological experience...

318

Human MSH2 protein  

DOE Patents [OSTI]

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

de la Chapelle, Albert (Helsingfors, FI); Vogelstein, Bert (Baltimore, MD); Kinzler, Kenneth W. (Baltimore, MD)

1997-01-01T23:59:59.000Z

319

Human MSH2 protein  

DOE Patents [OSTI]

The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error{sup +} (RER{sup +}) tumor cells. 19 figs.

Chapelle, A. de la; Vogelstein, B.; Kinzler, K.W.

1997-01-07T23:59:59.000Z

320

Potential commercial application of a bi-layer bone-ligament regeneration scaffold to anterior cruciate ligament replacement  

E-Print Network [OSTI]

A business model was created in order to explore the commercial application of a bi-layer bone-ligament scaffold to the treatment of torn anterior cruciate ligaments (ACL) requiring replacement. The two main keys in producing ...

Li, Jessica C. (Jessica Ching-Yi)

2006-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

Evaluation of the Effects of Green Tea Extracts on Bone Homeostasis in the Ts65Dn Down Syndrome Mouse Model  

E-Print Network [OSTI]

Evaluation of the Effects of Green Tea Extracts on Bone Homeostasis in the Ts65Dn Down Syndrome- gallate (EGCG), an aromatic polyphenol found in high concentrations in green tea, is a known inhibitor

Zhou, Yaoqi

322

Regional geologic characterization of the Second Bone Spring Sandstone, Delaware basin, Lea and Eddy Counties, New Mexico  

E-Print Network [OSTI]

The Bone Spring Formation is a series of interbedded siliciclastics and carbonates that were deposited in the Delaware basin during the Leonardian (Early Permian). It consists of the First, Second and Third Carbonate and the First, Second and Third...

Downing, Amanda Beth

2012-06-07T23:59:59.000Z

323

Accuracy and precision of lumbar bone mineral content by dual-energy X-ray absorptiometry in live female monkeys  

Science Journals Connector (OSTI)

Dual-energy X-ray absorptiometry (DXA) was used...in vivo bone mineral content (BMC) of lumbar vertebrae in 20...Macaca fascicularis). The ash weight of the third lumbar vertebra (L3) was compared to the measured...

M. J. Jayo; S. E. Rankin; D. S. Weaver; C. S. Carlson…

1991-01-01T23:59:59.000Z

324

3D printing as an efficient way for comparative study of biomimetic structures — trabecular bone and honeycomb  

Science Journals Connector (OSTI)

The mechanical properties of engineered trabecular bone and honeycomb structures are investigated by the combined use of the 3D printing technology and the compression test. The engineered ... those by the previo...

Yong-Jin Yoon; Seung Ki Moon; Jihong Hwang

2014-11-01T23:59:59.000Z

325

Human Rights and Duties  

Science Journals Connector (OSTI)

... European convention. A draft European convention for the collective protection of individual rights and democratic liberties by member States of the Council of Europe, and for the establishment of a ... accompanied by a recommendation that the whole question of the maintenance of human rights and liberties should be placed upon the agenda of the first session of the European Consultative Assembly ...

1950-01-21T23:59:59.000Z

326

Ubiquitous human computing  

Science Journals Connector (OSTI)

...tomorrow's human one. The Internet faced down proprietary networks...organically the way that the Internet's byways are not owned in...that is in the way the current Internet and its protocols are unowned...significantly different vectors of abuse and control than the one run...

2008-01-01T23:59:59.000Z

327

Ethics, humanity, and science  

Science Journals Connector (OSTI)

Ethics, humanity, and science ... In this issue of the magazine C&EN senior editor Wil Lepkowski, in effect, picks up on this theme with an examination of a debate that may be about to erupt over the methods and ethics of science and scientists, particularly as they apply to the central role of science and technology in the nuclear arms race. ...

MICHEAL HEYLIN

1981-10-05T23:59:59.000Z

328

THE SCIENCE OF HUMANITY  

Science Journals Connector (OSTI)

...one as silver and the other as gold, and have done doughty battle in defense of their one-sided vision; the biol-ogist...peoples, or of human curiosities and monstrosities exhibited in midway plaisances, if nlot in circuses and dime mu-seums. Even...

W J MCGEE

1897-09-17T23:59:59.000Z

329

Cellular response of the primate (M. mulatta) spleen to bone marrow transplantation in gamma irradiated recipients  

E-Print Network [OSTI]

. They further stated that this disease was due to the combined effects of late radiation damage, immunologic reaction of the graft against the host and impaired immunologic defense against micro- organisms. Foreign bone marrow treatment was effective only... physicists who had been experimenting with a source that emitted neutron and gamma rays. Five of these physicists were exposed to lethal doses of ioniz- ing radiation. Hemograms taken on October 30, 1958, showed total aplasia. Supportive therapy had...

Fraunfelter, Frank Clare

1966-01-01T23:59:59.000Z

330

Automatic detection of bone fragments in poultry using multi-energy x-rays  

DOE Patents [OSTI]

At least two linear arrays of x-ray detectors are placed below a conveyor belt in a poultry processing plant. Multiple-energy x-ray sources illuminate the poultry and are detected by the detectors. Laser profilometry is used to measure the poultry thickness as the x-ray data is acquired. The detector readout is processed in real time to detect the presence of small highly attenuating fragments in the poultry, i.e., bone, metal, and cartilage.

Gleason, Shaun S. (Knoxville, TN); Paulus, Michael J. (Knoxville, TN); Mullens, James A. (Knoxville, TN)

2002-04-09T23:59:59.000Z

331

Proposed BackBone API Preliminary Draft v1.0  

E-Print Network [OSTI]

Smart Trek Proposed BackBone API Preliminary Draft v1.0 Table of Contents 1.0) API diagram / Introduction 2.0) Requirements 3.0) Class skeletons 4.0) Isp Examples 4.1) Domain Inbound API example 4.2) SDD Inbound API example 4.3) SDD Outbound API example 4.4) ItsFrame Inbound API example 4.5) ItsFrame Outbound

332

miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2  

Science Journals Connector (OSTI)

... a miR-34a precursor (pre-miR-34a) but enhanced by an antisense miR-34a inhibitor (anti-miR-34a), indicating that miR-34a regulation of bone resorption in mice ... -34a mimic can attenuate postmenopausal osteoporosis using an ovariectomy (OVX) mouse model and a chitosan (CH) nanoparticle vehicle. Reduction of uterine weight in all ovariectomized mice indicated effective ...

Jing Y. Krzeszinski; Wei Wei; HoangDinh Huynh; Zixue Jin; Xunde Wang; Tsung-Cheng Chang; Xian-Jin Xie; Lin He; Lingegowda S. Mangala; Gabriel Lopez-Berestein; Anil K. Sood; Joshua T. Mendell; Yihong Wan

2014-06-25T23:59:59.000Z

333

Growth and bone development in weanling quarter horses fed diets supplemented with sodium zeolite-A  

E-Print Network [OSTI]

GROWTH AND BONE DEVELOPMENT IN WEANLING QUARTER HORSES FED DIETS SUPPLEMENTED WITH SODIUM ZEOLITE-A A Thesis by KIMBERLY SUZANNE FREY Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... in Weanling Quarter Horses Fed Diets Supplemented with Sodium Zeolite-A. (December 1991) Kimberly Suzanne Frey, B. S. , Texas A&M University Chair of Advisory Committee: Dr. Gary D. Potter Sixty Quarter Horse weanlings were used in a study to determine...

Frey, Kimberly Suzanne

2012-06-07T23:59:59.000Z

334

Human sciences The human sciences database contains approximately 254 academic  

E-Print Network [OSTI]

Human sciences The human sciences database contains approximately 254 academic journals and statistical reports on the following subjects: (comparative literature, theology, history and geography, education, psychology, arts, languages and Library Science) Social sciences The social sciences database

335

Human-elephant conflicts; Human-elephant conflicts.  

E-Print Network [OSTI]

?? It is widely recognized that human-wildlife conflicts can reduce farmers’ support for long-term species conservation. The subject of human-elephant conflicts is highly relevant in… (more)

Olsson, Linnea

2014-01-01T23:59:59.000Z

336

Research Using Human Subjects/Materials  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Research Using Human SubjectsMaterials (taken in part from "Research on Human Specimens", National Institutes of Health) A 'human subject' is a living individual about whom an...

337

PIA - Human Resources Information System (HRIS) | Department...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Information System (HRIS) PIA - Human Resources Information System (HRIS) PIA - Human Resources Information System (HRIS) PIA - Human Resources Information System (HRIS) More...

338

PIA - Human Resources Management Information System (HRMIS) ...  

Energy Savers [EERE]

Information System (HRMIS) PIA - Human Resources Management Information System (HRMIS) PIA - Human Resources Management Information System (HRMIS) PIA - Human Resources Management...

339

Radiation effects on humans  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Radiation effects on humans Radiation effects on humans Name: Joe Kemna Location: N/A Country: N/A Date: N/A Question: I am trying to find information on radiation. I need the effects on humans, the damage it causes to the environment, and any extra information you might have on the subject. Thank you for your time. Replies: Your library should be a good place to start, but first you need to narrow your question a bit. "Radiation" means radio waves, heat, light (including the ultraviolet light that causes suntan and sunburn), and what's called "ionizing radiation." By far the major source of the first three is the Sun, while the last I believe comes principally from cosmic rays and various naturally radioactive elements like uranium and radon. The most significant manmade sources of exposure would --- I think --- be household wiring and appliances (radio), engines and heating devices (heat), lamps (light), and X-ray machines, flying at high altitude in airplanes, and living in well-insulated homes built over radon sources (ionizing radiation). Heat, light and ionizing radiation play vital roles in the ecology of the Earth. Radio, light (in particular "tanning" ultraviolet), and ionizing radiation have all been widely assumed at different times to be particularly good or particularly bad for human health. Some recent issues of public concern have been the effect of radio waves from electric transmission lines, the effect on skin cancer incidence from tanning and sunburns, the depletion of the ultraviolet-light-produced ozone in the upper atmosphere by chlorofluorocarbons (CFCs), "global warming" from the increased absorption of heat radiation from the surface by atmospheric carbon dioxide and methane, and the effect of a long exposure to low levels of ionizing radiation as for example the people of Eastern Europe are experiencing from the Chernobyl nuclear power plant accident.

340

Human Genetics Portfolio Review Summary  

E-Print Network [OSTI]

the past 20 years, from our contribution to the Human Genome Project at the Sanger Institute to our role during this time. The drive to maximise the health benefits of human genome research remains a core to build research capacity and infrastructure to support human genetics and genomics · providing generous

Rambaut, Andrew

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Human Capital Management Accountability Program  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The Order establishes requirements, roles and responsibilities for the Human Capital Management Accountability Program (HCMAP) for human resources programs and personnel and ensures that human capital activities are regulatory and procedurally compliant with Federal statutes and Departmental policies. Does not cancel other directives.

2008-08-01T23:59:59.000Z

342

Eye Color in Humans  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Eye Color in Humans Eye Color in Humans Name: Kristi Location: N/A Country: N/A Date: N/A Question: The dominant characteristic is the one most likely to appear in the offspring. In human beings, brown is the dominant color for eyes. The children who inherit at least on dominant gene will have either brown, green, or hazel eyes. Only childten who inherit two recessive genes will have pure blue eyes. If there are eight children in the family, what color eyes will most of them have? Replies: http://www.newton.dep.anl.gov/archive.htm Search under eye color Steve Sample You answer is of course dependent on the genes of the parents. If both parents do not have the recessive gene, then no children will have light colored eyes. If one has a recessive gene and the other not, then still no children will have light color eyes and on the average 25% of the eight children could have the recessive gene. If both parents have the recessive gene, then 25% of the eight children could have light color eyes.

343

Dog vs. human language  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Dog vs. human language Dog vs. human language Name: Michelle Conte Location: N/A Country: N/A Date: N/A Question: Why can't dogs talk like humans? Replies: In very simple terms, they aren't made for it. In order to produce any kind of vocal sound, we not only need a set of vocal chords (or vibratory organs of some sort), we also need an air pipe and cranium shaped to deliver the vibrations in the right way -- you actually use your own head as a sort of sounding plate for several primary sounds (non-percussive) Dogs don't have the right shaped heads for the job, as well as the inability to vocalize many of the percussive sounds which make up a good percentage of our languages due to a differently shaped mouth. However, all things considered, we'd be ill-equipped to call meetings over long distances by simply howling, like dogs and their kin are wont to do in the wild.

344

E-Print Network 3.0 - assessing biomechanical exposures Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

. Biomechanics of cortical and trabecular bone: implications for assessment of fracture risk 3. Modeling... BME 473 Applied Biomechanics Every Spring Semester 2004-2005...

345

On the bone response to oxidized titanium implants. The role of microporous structure and chemical composition of the surface oxide in enhanced osseointegration.  

E-Print Network [OSTI]

??Background: Titanium implants have been widely used clinically for various types of bone-anchored reconstructions. A thin native oxide film, naturally formed on titanium implants contacts… (more)

Sul, Young-Taeg 1960-

2002-01-01T23:59:59.000Z

346

A Gene Map of the Human Genome  

Science Journals Connector (OSTI)

...sanger.ac.uk/ Stanford Human Genome Center http://www-shgc.stanford.edu/ Wellcome Trust Centre for Human...sanger.ac.ukl Stanford Human Genome Center http://www-shgc.stanford.edu/ Wellcome Trust Centre for Human Genetics http...

G. D. Schuler; M. S. Boguski; E. A. Stewart; L. D. Stein; G. Gyapay; K. Rice; R. E. White; P. Rodriguez-Tomé; A. Aggarwal; E. Bajorek; S. Bentolila; B. B. Birren; A. Butler; A. B. Castle; N. Chiannilkulchai; A. Chu; C. Clee; S. Cowles; P. J. R. Day; T. Dibling; N. Drouot; I. Dunham; S. Duprat; C. East; C. Edwards; J.-B. Fan; N. Fang; C. Fizames; C. Garrett; L. Green; D. Hadley; M. Harris; P. Harrison; S. Brady; A. Hicks; E. Holloway; L. Hui; S. Hussain; C. Louis-Dit-Sully; J. Ma; A. MacGilvery; C. Mader; A. Maratukulam; T. C. Matise; K. B. McKusick; J. Morissette; A. Mungall; D. Muselet; H. C. Nusbaum; D. C. Page; A. Peck; S. Perkins; M. Piercy; F. Qin; J. Quackenbush; S. Ranby; T. Reif; S. Rozen; C. Sanders; X. She; J. Silva; D. K. Slonim; C. Soderlund; W.-L. Sun; P. Tabar; T. Thangarajah; N. Vega-Czarny; D. Vollrath; S. Voyticky; T. Wilmer; X. Wu; M. D. Adams; C. Auffray; N. A. R. Walter; R. Brandon; A. Dehejia; P. N. Goodfellow; R. Houlgatte; J. R. Hudson Jr.; S. E. Ide; K. R. Iorio; W. Y. Lee; N. Seki; T. Nagase; K. Ishikawa; N. Nomura; C. Phillips; M. H. Polymeropoulos; M. Sandusky; K. Schmitt; R. Berry; K. Swanson; R. Torres; J. C. Venter; J. M. Sikela; J. S. Beckmann; J. Weissenbach; R. M. Myers; D. R. Cox; M. R. James; D. Bentley; P. Deloukas; E. S. Lander; T. J. Hudson

1996-10-25T23:59:59.000Z

347

Mentoring Human Performance - 12480  

SciTech Connect (OSTI)

Although the positive effects of implementing a human performance approach to operations can be hard to quantify, many organizations and industry areas are finding tangible benefits to such a program. Recently, a unique mentoring program was established and implemented focusing on improving the performance of managers, supervisors, and work crews, using the principles of Human Performance Improvement (HPI). The goal of this mentoring was to affect behaviors and habits that reliably implement the principles of HPI to ensure continuous improvement in implementation of an Integrated Safety Management System (ISMS) within a Conduct of Operations framework. Mentors engaged with personnel in a one-on-one, or one-on-many dialogue, which focused on what behaviors were observed, what factors underlie the behaviors, and what changes in behavior could prevent errors or events, and improve performance. A senior management sponsor was essential to gain broad management support. A clear charter and management plan describing the goals, objectives, methodology, and expected outcomes was established. Mentors were carefully selected with senior management endorsement. Mentors were assigned to projects and work teams based on the following three criteria: 1) knowledge of the work scope; 2) experience in similar project areas; and 3) perceived level of trust they would have with project management, supervision, and work teams. This program was restructured significantly when the American Reinvestment and Recovery Act (ARRA) and the associated funding came to an end. The program was restructured based on an understanding of the observations, attributed successes and identified shortfalls, and the consolidation of those lessons. Mentoring the application of proven methods for improving human performance was shown effective at increasing success in day-to-day activities and increasing confidence and level of skill of supervisors. While mentoring program effectiveness is difficult to measure, and return on investment is difficult to quantify, especially in complex and large organizations where the ability to directly correlate causal factors can be challenging, the evidence presented by Sydney Dekker, James Reason, and others who study the field of human factors does assert managing and reducing error is possible. Employment of key behaviors-HPI techniques and skills-can be shown to have a significant impact on error rates. Our mentoring program demonstrated reduced error rates and corresponding improvements in safety and production. Improved behaviors are the result, of providing a culture with consistent, clear expectations from leadership, and processes and methods applied consistently to error prevention. Mentoring, as envisioned and executed in this program, was effective in helping shift organizational culture and effectively improving safety and production. (authors)

Geis, John A.; Haugen, Christian N. [CALIBRE Systems, Inc., Alexandria, Virginia (United States)

2012-07-01T23:59:59.000Z

348

Human Genome Program  

SciTech Connect (OSTI)

The DOE Human Genome program has grown tremendously, as shown by the marked increase in the number of genome-funded projects since the last workshop held in 1991. The abstracts in this book describe the genome research of DOE-funded grantees and contractors and invited guests, and all projects are represented at the workshop by posters. The 3-day meeting includes plenary sessions on ethical, legal, and social issues pertaining to the availability of genetic data; sequencing techniques, informatics support; and chromosome and cDNA mapping and sequencing.

Not Available

1993-01-01T23:59:59.000Z

349

Modified fish-bone model: A simplified MDOF model for simulation of seismic responses of moment resisting frames  

Science Journals Connector (OSTI)

Abstract This paper presents a simplified Multi-Degree-Of-Freedom (MDOF) model through modification of fish-bone model (or generic frame). Modified Fish-Bone (MFB) model is developed through three enhancements: (i) the moment of inertia for half-beams is reduced slightly to modify the assumption of equal rotation at each story joints, (ii) a number of truss elements are inserted to the fish-bone model to simulate flexural deformation of moment frames due to axial elongation and contraction of columns, and (iii) moment–rotation relationship of representative rotational springs is supposed to be bilinear instead of trilinear in order to consider simultaneous yielding at both ends of the beam in moment frames. The proposed model is evaluated with respect to nonlinear dynamic analysis results of three classic moment resisting frames subjected to 94 records of FEMA-440 ground motion data set. Moreover, the adequacy of this model is compared with the fish-bone model and two predictors of nonlinear seismic demand. The statistical study of predicted interstory drift demonstrates the superiority of the proposed model over the fish-bone model and both seismic demand predictors.

A.R. Khaloo; H. Khosravi

2013-01-01T23:59:59.000Z

350

The reproducibility of [sup 109]Cd-based X-ray fluorescence measurements of bone lead  

SciTech Connect (OSTI)

We assessed the reproducibility of X-ray fluorescence-based lead measurements from multiple measurements made on a low-concentration plaster of paris phantom and in five subjects measured five times on two occasions. Over a 6-month period, 220 measurements of the same phantom were obtained and showed a standard deviation of 1.29 [mu]g Pb (g plaster of paris)[sup [minus]1]. The two sets of in vivo measurements were made 10 months apart and revealed a mean standard deviation of 3.4 [mu]Pb (g bone mineral)[sup [minus]1] and 5.1 [mu]g Pb (g bone mineral)[sup [minus]1] for males and females, respectively. Our measured standard deviation exceeded by 20-30% the calculated standard deviation associated with a single measurement both in the phantom and in subjects. This indicates that some variance is introduced during the measurement process. Operator learning and consistency significantly minimized this increased variability. Measured lead concentrations of the left and right tibia in 14 subjects showed no significant differences between legs. As a result, either tibia can be sampled and compared over time. The levels of reproducibility we report here mean that X-ray fluorescence-based determinations of bone lead concentrations are reliable both over the short and long term. Thus, reasonably sized confidence intervals can be placed on detected changes in concentration and should permit acquisition of longitudinal data within a reasonable length of time. 19 refs., 1 fig., 6 tabs.

Gordon, C.L. (Chedoke-McMaster Hospitals, Hamilton, Ontario (Canada)); Webber, C.E.; Chettle, D.R. (McMaster Univ., Hamilton, Ontario (Canada))

1994-08-01T23:59:59.000Z

351

Long bone growth of Mimbres subadults from the NAN Ranch (LA15049), New Mexico  

E-Print Network [OSTI]

of 559 skeletons from three time periods (Late Woodland, Mississippian Acculturated Late Woodland, and Table 2. 2. Indian Knoll maximum long bone length (cm) without epiphysis*. 10 13 14 15 16 17 18 2. 5 ? 3. 5 yr. 3. 5 ? 4. 5 yr. 4. 5 ? 5. 5... yr. 5. 5 ? 6. 5 yr. 6. 5 ? 8 yr. 8 ? 10. 5 yr. 10. 5 ? 11 yr. 11 ? 12 yr. 12 yl ~ 15 yr. + 6 mo. 15 yr. 16 yz' ~ 16. 5 ? 17 yr. 21 yr ~ Age Group Age 1 Birth ? 6 mo. 6 ? 15 mo. 15 ? 24 mo. 4 2 ? 2. 5 yr. Humerus N Mean SD Range 5...

Marek, Marianne

2012-06-07T23:59:59.000Z

352

Reconstructing Cortical Dynamics with Magnetoencephalography  

E-Print Network [OSTI]

ciently on modern high performance computing clusters. Thiswell-suited to run on high performance computing clusters. Savailability of high performance computing clusters (e.g. ,

Dalal, Sarang S.

2007-01-01T23:59:59.000Z

353

Cortical Microstimulation for Neural Prostheses  

E-Print Network [OSTI]

decreased firing rate (mediated by inhibitory circuits [84])circuit must be able to replace specific contact signals from the trigeminal ganglia with neuronal firing

Venkatraman, Subramaniam

2010-01-01T23:59:59.000Z

354

Reconstructing Cortical Dynamics with Magnetoencephalography  

E-Print Network [OSTI]

magnetic ?elds pro- duced by alpha-rhythm currents. Science,Science, movement beta rebound is generated in motor cortex: Evidence from neuro- magnetic

Dalal, Sarang S.

2007-01-01T23:59:59.000Z

355

Cortical Microstimulation for Neural Prostheses  

E-Print Network [OSTI]

Electrolysis of water . . . . . . . . . . . . . . . . . . .case can lead to electrolysis of water as shown in Figuremetal Figure 2.5: Electrolysis of water using microelectrode

Venkatraman, Subramaniam

2010-01-01T23:59:59.000Z

356

Report: EM Human Capital Initiatives  

Broader source: Energy.gov (indexed) [DOE]

HUMAN CAPITAL HUMAN CAPITAL September 25, 2008 Submitted by the EMAB Human Capital Subcommittee Background: The enhancement of the Office of Environmental Management's (EM) human capital has been a central tenet of the Assistant Secretary's tenure, reflecting the critical nature of this resource to the achievement of EM's mission. Beginning in Fiscal Year (FY) 2006, the Environmental Management Advisory Board (EMAB or Board) has reviewed the program's human capital issues and the plans EM has developed to address them. This review produced a number of recommendations that were presented in the Board's FY 2006 report to the Assistant Secretary and were later approved and implemented to varying degrees. * Recommendation 2006-01: Develop accountability for the Human Capital Plan

357

Origin of the pattern of trabecular bone: An experiment and a model  

Science Journals Connector (OSTI)

As a result of an experiment in which the development of a mineral phase in the rabbit embryo was observed, a model is proposed to explain the mechanism that controls the place of precipitation of crystals in mineralizing tissue. The reaction-diffusion equations for the specified compounds are formulated and solved. Among a variety of compounds the concentrations of carbon dioxide, oxygen, HCO3- ions, H+ ions, calcium, and inorganic phosphorus are evaluated.? CO2, HCO3- ions, and H+ ions, are distinguished due to their key role in the maintenance of the pH value. The local concentration of oxygen is the pivot factor that controls the metabolic rate, i.e., production of CO2. Next the supersaturation was estimated on the basis of the calculated values of pH and the concentrations of calcium and inorganic phosphorus. It is assumed that the synthesis of the organic matrix breaks the metastable equilibrium with respect to spontaneous precipitation and leads to the deposition of minerals. It was found that the geometry of the vasculature determines the shape of primitive trabecular bone (woven bone) while the value of the diffusion coefficient may be the key factor indicating the possibility of mineralization under the control of a living organism.

Zbis?aw Tabor; Eugeniusz Rokita; Tadeusz Cichocki

2002-11-13T23:59:59.000Z

358

Human Reliability Program Workshop  

SciTech Connect (OSTI)

A Human Reliability Program (HRP) is designed to protect national security as well as worker and public safety by continuously evaluating the reliability of those who have access to sensitive materials, facilities, and programs. Some elements of a site HRP include systematic (1) supervisory reviews, (2) medical and psychological assessments, (3) management evaluations, (4) personnel security reviews, and (4) training of HRP staff and critical positions. Over the years of implementing an HRP, the Department of Energy (DOE) has faced various challenges and overcome obstacles. During this 4-day activity, participants will examine programs that mitigate threats to nuclear security and the insider threat to include HRP, Nuclear Security Culture (NSC) Enhancement, and Employee Assistance Programs. The focus will be to develop an understanding of the need for a systematic HRP and to discuss challenges and best practices associated with mitigating the insider threat.

Landers, John; Rogers, Erin; Gerke, Gretchen

2014-05-18T23:59:59.000Z

359

Annotating individual human genomes  

Science Journals Connector (OSTI)

Advances in DNA sequencing technologies have made it possible to rapidly, accurately and affordably sequence entire individual human genomes. As impressive as this ability seems, however, it will not likely amount to much if one cannot extract meaningful information from individual sequence data. Annotating variations within individual genomes and providing information about their biological or phenotypic impact will thus be crucially important in moving individual sequencing projects forward, especially in the context of the clinical use of sequence information. In this paper we consider the various ways in which one might annotate individual sequence variations and point out limitations in the available methods for doing so. It is arguable that, in the foreseeable future, DNA sequencing of individual genomes will become routine for clinical, research, forensic, and personal purposes. We therefore also consider directions and areas for further research in annotating genomic variants.

Ali Torkamani; Ashley A. Scott-Van Zeeland; Eric J. Topol; Nicholas J. Schork

2011-01-01T23:59:59.000Z

360

Simulating human behavior for national security human interactions.  

SciTech Connect (OSTI)

This 3-year research and development effort focused on what we believe is a significant technical gap in existing modeling and simulation capabilities: the representation of plausible human cognition and behaviors within a dynamic, simulated environment. Specifically, the intent of the ''Simulating Human Behavior for National Security Human Interactions'' project was to demonstrate initial simulated human modeling capability that realistically represents intra- and inter-group interaction behaviors between simulated humans and human-controlled avatars as they respond to their environment. Significant process was made towards simulating human behaviors through the development of a framework that produces realistic characteristics and movement. The simulated humans were created from models designed to be psychologically plausible by being based on robust psychological research and theory. Progress was also made towards enhancing Sandia National Laboratories existing cognitive models to support culturally plausible behaviors that are important in representing group interactions. These models were implemented in the modular, interoperable, and commercially supported Umbra{reg_sign} simulation framework.

Bernard, Michael Lewis; Hart, Dereck H.; Verzi, Stephen J.; Glickman, Matthew R.; Wolfenbarger, Paul R.; Xavier, Patrick Gordon

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

RECRUITMENT SEARCH FIRMS HUMAN RESOURCES  

E-Print Network [OSTI]

RECRUITMENT SEARCH FIRMS HUMAN RESOURCES GUIDELINES Workforce Planning | Washington Square, San by the Workforce Planning Unit in Human Resources at SJSU. Process Consistent, defensible processes for evaluating of the recruitment. - At this meeting, the Workforce Planning analyst can provide contact information for search

Su, Xiao

362

Human viruses: discovery and emergence  

Science Journals Connector (OSTI)

...whether or not it poses a risk to humans, would be...will pose a serious risk to public health but...situation will require both political will and considerable investment in infrastructure...Woolhouse, M. E. J. 2001 Risk factors for human disease...

2012-01-01T23:59:59.000Z

363

The human activity of visualization  

E-Print Network [OSTI]

Griffin et al 2006 #12;Human-Computer Interaction: Software of the Mind each user has a setThe human activity of visualization cultural and psychological factors in representation; Gibbon 1998; Marcus 2000) conventions and metaphors of Westerners may not hold worldwide colors

Wright, Dawn Jeannine

364

Human Genome Research: Decoding DNA  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Human Genome Research: Decoding DNA Human Genome Research: Decoding DNA Resources with Additional Information Charles DeLisi As head of DOE's Office of Health and Environmental Research, Charles DeLisi played a pivotal role in proposing and initiating the Human Genome Program in 1986. The U.S. Department of Energy (DOE) has historically been active in supporting human genome research. On September 10, 2003, Secretary of Energy Spencer Abraham presented the Secretary's Gold Award to Aristides Patrinos and Francis Collins for their leadership of the government's Human Genome Project. At DOE's Office of Science, Dr. Patrinos is the Associate Director for Biological and Environmental Research. He has been a researcher at the department's Oak Ridge National Laboratory and Brookhaven National Laboratory.

365

T cells stimulate catabolic gene expression by the stromal cells from giant cell tumor of bone  

SciTech Connect (OSTI)

Highlights: Black-Right-Pointing-Pointer Two T cell lines stimulate PTHrP, RANKL, MMP13 gene expression in GCT cell cultures. Black-Right-Pointing-Pointer CD40 expressed by stromal cells; CD40L detected in whole tumor but not cultures. Black-Right-Pointing-Pointer Effect of CD40L treatment on GCT cells increased PTHrP and MMP13 gene expression. Black-Right-Pointing-Pointer PTHrP treatment increased MMP13 expression, while inhibition decreased expression. Black-Right-Pointing-Pointer T cells may stimulate GCT stromal cells and promote the osteolysis of the tumor. -- Abstract: The factors that promote the localized bone resorption by giant cell tumor of bone (GCT) are not fully understood. We investigated whether T cells could contribute to bone resorption by stimulating expression of genes for parathyroid hormone-related protein (PTHrP), matrix metalloproteinase (MMP)-13, and the receptor activator of nuclear-factor {kappa}B ligand (RANKL). Two cell lines, Jurkat clone E6-1 and D1.1, were co-cultured with isolated GCT stromal cells. Real-time PCR analyses demonstrated a significant increase of all three genes following 48 h incubation, and PTHrP and MMP-13 gene expression was also increased at 24 h. Further, we examined the expression of CD40 ligand (CD40L), a protein expressed by activated T cells, and its receptor, CD40, in GCT. Immunohistochemistry results revealed expression of the CD40 receptor in both the stromal cells and giant cells of the tumor. RNA collected from whole GCT tissues showed expression of CD40LG, which was absent in cultured stromal cells, and suggests that CD40L is expressed within GCT. Stimulation of GCT stromal cells with CD40L significantly increased expression of the PTHrP and MMP-13 genes. Moreover, we show that inhibition of PTHrP with neutralizing antibodies significantly decreased MMP13 expression by the stromal cells compared to IgG-matched controls, whereas stimulation with PTHrP (1-34) increased MMP-13 gene expression. These results suggest that T cells may potentiate the catabolic effect of GCT.

Cowan, Robert W. [Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada) [Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada); Juravinski Cancer Centre, 699 Concession St., Hamilton, ON, Canada L8V 5C2 (Canada); Ghert, Michelle [Juravinski Cancer Centre, 699 Concession St., Hamilton, ON, Canada L8V 5C2 (Canada) [Juravinski Cancer Centre, 699 Concession St., Hamilton, ON, Canada L8V 5C2 (Canada); Department of Surgery, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada); Singh, Gurmit, E-mail: gurmit.singh@jcc.hhsc.ca [Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada) [Department of Pathology and Molecular Medicine, McMaster University, 1280 Main St. W., Hamilton, ON, Canada L8S 4L8 (Canada); Juravinski Cancer Centre, 699 Concession St., Hamilton, ON, Canada L8V 5C2 (Canada)

2012-03-23T23:59:59.000Z

366

Abstract P1-13-08: A Cross-Sectional Study Evaluating Bone Quantity and Quality in Women with Bone Metastases from Breast Cancer  

Science Journals Connector (OSTI)

...investigate low linear energy transfer (LET) radiation-induced...target size and radiation quality and are likely to have...involved high linear energy transfer (LET) alpha-particles...target size and radiation quality and are likely to have...Humans Hybrid Cells Linear Energy Transfer Magnetics Mutagenesis...

OC Freedman; E Amir; AM Cheung; H Hu; E Lee; G Dranitsaris; and MJ. Clemons

2010-12-15T23:59:59.000Z

367

Human Reliability Analysis for Digital Human-Machine Interfaces  

SciTech Connect (OSTI)

This paper addresses the fact that existing human reliability analysis (HRA) methods do not provide guidance on digital human-machine interfaces (HMIs). Digital HMIs are becoming ubiquitous in nuclear power operations, whether through control room modernization or new-build control rooms. Legacy analog technologies like instrumentation and control (I&C) systems are costly to support, and vendors no longer develop or support analog technology, which is considered technologically obsolete. Yet, despite the inevitability of digital HMI, no current HRA method provides guidance on how to treat human reliability considerations for digital technologies.

Ronald L. Boring

2014-06-01T23:59:59.000Z

368

Interspecic scaling of the hindlimb skeleton in lizards, crocodilians, felids and canids: does limb bone shape correlate  

E-Print Network [OSTI]

limb bone shape correlate with limb posture? Richard W. Blob* Committee on Evolutionary Biology-phylogenetic statistical methods and phylogenetically independent contrasts. Comparisons with theoretical models indicate to such an extent that for the femur and tibia safety factors in shear are approximately half as great as safety

Blob, Richard W.

369

Numerical investigation into blood clotting at the bone-dental implant interface in the presence of an electrical stimulus  

Science Journals Connector (OSTI)

The insertion of a dental implant activates a sequence of wound healing events ending with bone formation and implant osseointegration. This sequence starts with the blood coagulation process and the formation of a fibrin network that detains spilt blood. ... Keywords: Blood clotting, Dental implant, Electrical stimulation, Mathematical model

J. C. Vanegas-Acosta; D. A. Garzón-Alvarado; V. Lancellotti

2013-12-01T23:59:59.000Z

370

Physico-chemical characterization and in vitro biological evaluation of pure SiHA for bone tissue engineering application  

E-Print Network [OSTI]

Supérieure des Mines de Saint-Etienne, CIS-EMSE, CNRS: FRE3312, F-42023 158 Cours Fauriel, SaintHA surface. Introduction Large bone defects resulting from trauma, cancer or malformations remain significant the real effects of Si substitution on the biological activity of HA in biological environment [6-8]. hal

Paris-Sud XI, Université de

371

Fracture Mechanisms of Bone: A Comparative Study between Antler and Bovine Femur , F.A. Sheppard2  

E-Print Network [OSTI]

Fracture Mechanisms of Bone: A Comparative Study between Antler and Bovine Femur P.Y. Chen1 , F, University of California, San Diego, La Jolla, CA 92093-0411, U.S.A. ABSTRACT In this study, fracture conditions to study the effects of fiber orientation and hydration. Fracture toughness results

McKittrick, Joanna

372

Bone Acquisition in Healthy Children and Adolescents: Comparisons of Dual-Energy X-Ray Absorptiometry and  

E-Print Network [OSTI]

and Radiology and Division of Endocrinology and Metabolism, Childrens Hospital Los Angeles, Los Angeles pediatric bone measurements using DXA. Height, weight, body mass index, skeletal age, and Tanner stageBMD in healthy children (2­13). Although DXA studies in pediatrics have provided much information re- garding

Valero-Cuevas, Francisco

373

The degree of bone mineralization is maintained with single intravenous bisphosphonates in aged estrogen-deficient rats and  

E-Print Network [OSTI]

estrogen-deficient rats and is a strong predictor of bone strength Wei Yao a , Zhiqiang Cheng a , Kurt J rats were ovariectomized and treated with a single dose of risedronate (intravenous, iv, 500 g was not changed with OVX or with anti-resorptive treatments. In conclusion, in the aged estrogen-deficient rat

Ritchie, Robert

374

Lead and cadmium in human hair: A comparison among four countries  

SciTech Connect (OSTI)

Concern over the health hazards caused by lead and cadmium in the environment has been emphasized by several investigators. Unlike other biological specimens (e.g. the blood and urine) which indicate recent exposure, trace metal content of hair correlates with body stores, especially of bones, and reflects for each individual, specific factors of genetical and environmental origins. In this paper the authors present results of a survey of lead and cadmium in human hair among four suburban university communities from four countries, two European (England West Germany), one Asian (Saudi Arabia) and one African (Sudan). Hair samples were analyzed for lead and cadmium in order to compare levels and distribution between populations of different ethnic background and geographical location. An attempt was made to study correlations, if any, between levels of lead or cadmium and smoking habits or sex.

Ahmed, A.F.M.; Elmubarak, A.H. (King Fahd Univ. of Petroleum and Minerals, Dhahran (Saudi Arabia))

1990-07-01T23:59:59.000Z

375

A framework for human microbiome research  

E-Print Network [OSTI]

A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome Project ...

Friedman, Jonathan

376

Guest editorial: Special issue on human computing  

E-Print Network [OSTI]

The seven articles in this special issue focus on human computing. Most focus on two challenging issues in human computing, namely, machine analysis of human behavior in group interactions and context-sensitive modeling.

Pantic, Maja

377

Human genome. 1993 Program report  

SciTech Connect (OSTI)

The purpose of this report is to update the Human Genome 1991-92 Program Report and provide new information on the DOE genome program to researchers, program managers, other government agencies, and the interested public. This FY 1993 supplement includes abstracts of 60 new or renewed projects and listings of 112 continuing and 28 completed projects. These two reports, taken together, present the most complete published view of the DOE Human Genome Program through FY 1993. Research is progressing rapidly toward 15-year goals of mapping and sequencing the DNA of each of the 24 different human chromosomes.

Not Available

1994-03-01T23:59:59.000Z

378

Corporate Human Resources Information Services (CHIRS) PIA, Office...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol Management Corporate Human Resources Information Services (CHIRS) PIA, Office of Human Capitol...

379

Scientists Help Define the Healthy Human Microbiome  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Scientists Help Define the Healthy Human Microbiome Scientists Help Define the Healthy Human Microbiome Computing, bioinformatics, and microbial ecology resources play key role in...

380

Perception for Human Motion Understanding  

Science Journals Connector (OSTI)

The fact that people are embodied places powerful constraints on their motion. By leveraging these constraints, we can build systems to perceive human motion that are fast and robust. More importantly, by unde...

Christopher R. Wren

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

The water footprint of humanity  

Science Journals Connector (OSTI)

...America (the United States, Canada, Brazil, and Argentina...Ehrlich PR ( 1996 ) Human appropriation of renewable fresh water . Science 271 : 785 – 788 . 6...domestic water supply sector. Water use in energy production is included in the figures...

Arjen Y. Hoekstra; Mesfin M. Mekonnen

2012-01-01T23:59:59.000Z

382

Director Human Resources Assoc Director  

E-Print Network [OSTI]

Director ­ Human Resources Assoc Director Workforce Planning & Organisational Change Director) - Organisational change - Workforce planning - Grievance & performance mgt support - Performance management line and not a formal Branch ** Includes Classifications ANU Search Workforce Planning* Remunerations

Botea, Adi

383

Unravelling daily human mobility motifs  

E-Print Network [OSTI]

Human mobility is differentiated by time scales. While the mechanism for long time scales has been studied, the underlying mechanism on the daily scale is still unrevealed. Here, we uncover the mechanism responsible for ...

Schneider, Christian M.

384

Molecular evolution of human paramyxoviruses  

Science Journals Connector (OSTI)

The nucleotide sequences of the NP and M genes of human parainfluenza type 1 virus (HPIV-1) were determined. The NP gene was 1677 nucleotides long excluding polyadenylic acid. The NP gene contained a single la...

K. Miyahara; S. Kitada; M. Yoshimoto; H. Matsumura; M. Kawano…

1992-01-01T23:59:59.000Z

385

HUMAN RESOURCES SIMON FRASER UNIVERSITY  

E-Print Network [OSTI]

. The position is responsible for developing test scenarios, responding to system problems by investigating regarding the design of testing scenarios and scripts and how to evaluate outcomes. Makes decisions1 HUMAN RESOURCES SIMON FRASER UNIVERSITY TEMPORARY ADMINISTRATIVE & PROFESSIONAL STAFF POSITION

386

Posthumanity, Transhumanism and Human Nature  

Science Journals Connector (OSTI)

...“Posthumanity” has established itself as a label for a form of human existence radically transformed by the most advanced medical techniques and by the use of neuro, bio and nano and other technologies for hum...

Dieter Birnbacher

2009-01-01T23:59:59.000Z

387

Technological Transformation of Human Experience  

Science Journals Connector (OSTI)

This article was inspired by Don Ihde's work on the experience of technology in human-machine relations. (See Don Ihde. "The Experience of Technology," Cultural Hermeneutics, Vol. 2, 1974, pp. 267-279.)

Arun Kumar Tripathi

2008-07-01T23:59:59.000Z

388

The water footprint of humanity  

Science Journals Connector (OSTI)

...the United Arab Emirates (571), Egypt (527...Ehrlich PR ( 1996 ) Human appropriation of renewable fresh water . Science 271 : 785 – 788 . 6...domestic water supply sector. Water use in energy production is included in the figures...

Arjen Y. Hoekstra; Mesfin M. Mekonnen

2012-01-01T23:59:59.000Z

389

Coördinating human-robot communication  

E-Print Network [OSTI]

As robots begin to emerge from the cloisters of industrial and military applications and enter the realms of coöperative partners for people, one of the most important facets of human-robot interaction (HRI) will be ...

Brööks, Andrëw G. (Brööks Zoz)

2007-01-01T23:59:59.000Z

390

The water footprint of humanity  

Science Journals Connector (OSTI)

...the United Arab Emirates (571), Egypt (527...world ( UNESCO , London ). 5 Postel SL Daily GC Ehrlich PR ( 1996 ) Human appropriation of...2008 ) The global component of freshwater demand and supply: An assessment of virtual water...

Arjen Y. Hoekstra; Mesfin M. Mekonnen

2012-01-01T23:59:59.000Z

391

Robot Manipulation in Human Environments  

E-Print Network [OSTI]

Human environments present special challenges for robot manipulation. They are often dynamic, difficult to predict, and beyond the control of a robot engineer. Fortunately, many characteristics of these settings can be ...

Edsinger, Aaron

2007-01-16T23:59:59.000Z

392

Robot manipulation in human environments  

E-Print Network [OSTI]

Human environments present special challenges for robot manipulation. They are often dynamic, difficult to predict, and beyond the control of a robot engineer. Fortunately, many characteristics of these settings can be ...

Edsinger, Aaron Ladd, 1972-

2007-01-01T23:59:59.000Z

393

Contractor Human Resource Management Programs  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09

1996-09-30T23:59:59.000Z

394

Contractor Human Resource Management Programs  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09.

1996-09-30T23:59:59.000Z

395

Mutations in Bone Marrow-Derived Stromal Stem Cells Unmask Latent Malignancy  

E-Print Network [OSTI]

Neoplastic epithelia may remain dormant and clinically unapparent in human patients for decades. Multiple risk factors including mutations in tumor cells or the stromal cells may affect the switch from dormancy to malignancy. ...

Houghton, JeanMarie

396

Multinuclear solid-state three-dimensional MRI of bone and synthetic calcium phosphates  

Science Journals Connector (OSTI)

...NMR Center, Room 2301, Department of Radiology, Massachusetts General Hospital, 149...Solid State Comm 50 : 291 – 295 . Human dental extractions were kindly provided by Dr. Andrew...NMR Center, Room 2301, Department of Radiology, Massachusetts General Hospital, 149...

Yaotang Wu; David A. Chesler; Melvin J. Glimcher; Leoncio Garrido; Jinxi Wang; Hong J. Jiang; Jerome L. Ackerman

1999-01-01T23:59:59.000Z

397

Protection of Human Research Subjects  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The order establishes Department of Energy (DOE) procedures and responsibilities for implementing the policy and requirements set forth in Title 10 Code of Federal Regulations (CFR) Part 745, Protection of Human Subjects, 45 CFR Part 46, and the Secretarial Policy Memorandum on Military or Intelligence-Related Human Subject Research, December 9, 2009. Cancels DOE O 443.1A and DOE P 443.1A.

2009-12-09T23:59:59.000Z

398

Human Genome Education Program  

SciTech Connect (OSTI)

The funds from the DOE Human Genome Program, for the project period 2/1/96 through 1/31/98, have provided major support for the curriculum development and field testing efforts for two high school level instructional units: Unit 1, ''Exploring Genetic Conditions: Genes, Culture and Choices''; and Unit 2, ''DNA Snapshots: Peaking at Your DNA''. In the original proposal, they requested DOE support for the partial salary and benefits of a Field Test Coordinator position to: (1) complete the field testing and revision of two high school curriculum units, and (2) initiate the education of teachers using these units. During the project period of this two-year DOE grant, a part-time Field-Test Coordinator was hired (Ms. Geraldine Horsma) and significant progress has been made in both of the original proposal objectives. Field testing for Unit 1 has occurred in over 12 schools (local and non-local sites with diverse student populations). Field testing for Unit 2 has occurred in over 15 schools (local and non-local sites) and will continue in 12-15 schools during the 96-97 school year. For both curricula, field-test sites and site teachers were selected for their interest in genetics education and in hands-on science education. Many of the site teachers had no previous experience with HGEP or the unit under development. Both of these first-year biology curriculum units, which contain genetics, biotechnology, societal, ethical and cultural issues related to HGP, are being implemented in many local and non-local schools (SF Bay Area, Southern California, Nebraska, Hawaii, and Texas) and in programs for teachers. These units will reach over 10,000 students in the SF Bay Area and continues to receive support from local corporate and private philanthropic organizations. Although HGEP unit development is nearing completion for both units, data is still being gathered and analyzed on unit effectiveness and student learning. The final field testing result from this analysis will contribute to the final revisions of each unit during the second-year of this grant.

Richard Myers; Lane Conn

2000-05-01T23:59:59.000Z

399

Beyond the tripartite cognition-emotion-interoception model of the human insular cortex  

Science Journals Connector (OSTI)

Functional MRI studies report insular activations across a wide range of tasks involving affective, sensory, and motor processing, but also during tasks of high-level perception, attention, and control. Although insular cortical activations are often ...

Lucina Q. Uddin; Joshua Kinnison; Luiz Pessoa; Michael L. Anderson

2014-01-01T23:59:59.000Z

400

Shotgun coverage of human genome computing  

E-Print Network [OSTI]

take about 1.5 million pages. The Human Genome Project would not be possible if our revolution were-author collection of chapters on the various uses of computing in the Human Genome Project. Peculiarly absent fromShotgun coverage of human genome computing Human Genome Computing, Second Edition edited by Martin

Eddy, Sean

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

The transcriptional activity of human Chromosome 22  

E-Print Network [OSTI]

information of the human genome is to obtain a detailed knowledge of human transcriptional coding sequences greatly increased our understanding of the biological information encoded on a human chromosome://array.mbb.yale.edu/chr22. [Keywords: Microarray; Chromosome 22; human genome; transcriptome; placental RNA; mouse homology

Gerstein, Mark

402

Course Information IB 364: Human Genome and  

E-Print Network [OSTI]

Course Information IB 364: Human Genome and Bioinformatics On this page: � Course Description � Technical Support Course Description Highlights advances in understanding the human genome, utilizing the human genome, applying bioinformatics to the genome, and realizing its potential to understand human

Kent, Angela

403

SCIENCE, POLITICS. AND THE HUMAN GENOM  

E-Print Network [OSTI]

/ Robert Cook-Deegan. p. cm. Includes bibliographical references. 1. Human Genome Project. 2. Human geneSCIENCE, POLITICS. AND THE HUMAN GENOM A scrupulous . . . narrative of the genesis and opening- DEEGAN #12;#12;#12;#12;The GENE WARS Science, Politics, and theHuman Genome ROBERT COOK-DEEGAN W - W

Richardson, David

404

Low-Income Weatherization: The Human Dimension  

Broader source: Energy.gov [DOE]

This presentation focuses on how the human dimension saves energy within low-income weatherization programs.

405

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

62 College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES of Architecture, Arts and Humanities offers one-of-a- kind opportunities for interdisciplinary exploration, but the enduring questions. The College of Architecture, Arts and Humanities is organized into three schools

Stuart, Steven J.

406

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

63 College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES of Architecture, Arts and Humanities offers one-of-a- kind opportunities for interdisciplinary exploration, but the enduring questions. The College of Architecture, Arts and Humanities is organized into three schools

Stuart, Steven J.

407

Virtual humans: back to the future  

Science Journals Connector (OSTI)

This paper essentially tries to examine all the roles that Virtual Humans can play in empowering human expression, and the research challenges we have to face to make this possible. It starts with a short history of Virtual Humans and how we contribute ... Keywords: computer animation, virtual humans, virtual reality

Nadia Magnenat Thalmann; Daniel Thalmann

2012-05-01T23:59:59.000Z

408

The SACADA database for human reliability and human performance  

SciTech Connect (OSTI)

Lack of appropriate and sufficient human performance data has been identified as a key factor affecting human reliability analysis (HRA) quality especially in the estimation of human error probability (HEP). The Scenario Authoring, Characterization, and Debriefing Application (SACADA) database was developed by the U.S. Nuclear Regulatory Commission (NRC) to address this data need. An agreement between NRC and the South Texas Project Nuclear Operating Company (STPNOC) was established to support the SACADA development with aims to make the SACADA tool suitable for implementation in the nuclear power plants' operator training program to collect operator performance information. The collected data would support the STPNOC's operator training program and be shared with the NRC for improving HRA quality. This paper discusses the SACADA data taxonomy, the theoretical foundation, the prospective data to be generated from the SACADA raw data to inform human reliability and human performance, and the considerations on the use of simulator data for HRA. Each SACADA data point consists of two information segments: context and performance results. Context is a characterization of the performance challenges to task success. The performance results are the results of performing the task. The data taxonomy uses a macrocognitive functions model for the framework. At a high level, information is classified according to the macrocognitive functions of detecting the plant abnormality, understanding the abnormality, deciding the response plan, executing the response plan, and team related aspects (i.e., communication, teamwork, and supervision). The data are expected to be useful for analyzing the relations between context, error modes and error causes in human performance.

Y. James Chang; Dennis Bley; Lawrence Criscione; Barry Kirwan; Ali Mosleh; Todd Madary; Rodney Nowell; Robert Richards; Emilie M. Roth; Scott Sieben; Antonios Zoulis

2014-05-01T23:59:59.000Z

409

Please send suggestions for improvement to John Webster, webster@engr.wisc.edu, 608-263-1574 9.12 BONES AND JOINTS  

E-Print Network [OSTI]

, like a chunk of rubber, and can even be bent into a loop. When collagen is removed from the bone by calcium varies rapidly with energy in this range of energies; the relatively large beam contains much

Lakes, Roderic

410

Combined effects of mechanical strain and hydroxyapatite/collagen composite on osteogenic differentiation of rat bone marrow derived mesenchymal stem cells  

Science Journals Connector (OSTI)

Mesenchymal stem cells (MSCs) represent a promising source for bone repair and regeneration. Recent lines of evidence have shown that appropriate strain could regulate the osteogenic differentiation of MSCs. Our previous study demonstrated that hydroxyapatite/collagen ...

Yan Huang; Xufeng Niu; Wei Song; Changdong Guan; Qingling Feng; Yubo Fan

2013-01-01T23:59:59.000Z

411

ATHENA, the Desktop Human "Body"  

ScienceCinema (OSTI)

Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

Iyer, Rashi; Harris, Jennifer

2015-01-05T23:59:59.000Z

412

ATHENA, the Desktop Human "Body"  

SciTech Connect (OSTI)

Creating surrogate human organs, coupled with insights from highly sensitive mass spectrometry technologies, a new project is on the brink of revolutionizing the way we screen new drugs and toxic agents. ATHENA, the Advanced Tissue-engineered Human Ectypal Network Analyzer project team, is developing four human organ constructs - liver, heart, lung and kidney - that are based on a significantly miniaturized platform. Each organ component will be about the size of a smartphone screen, and the whole ATHENA "body" of interconnected organs would fit neatly on a desk. "By developing this 'homo minutus,' we are stepping beyond the need for animal or Petri dish testing: There are huge benefits in developing drug and toxicity analysis systems that can mimic the response of actual human organs," said Rashi Iyer, a senior scientist at Los Alamos National Laboratory, the lead laboratory on the five-year, $19 million multi-institutional effort. The project is supported by the Defense Threat Reduction Agency (DTRA). Some 40 percent of pharmaceuticals fail their clinical trials, Iyer noted, and there are thousands of chemicals whose effects on humans are simply unknown. Providing a realistic, cost-effective and rapid screening system such as ATHENA with high-throughput capabilities could provide major benefits to the medical field, screening more accurately and offering a greater chance of clinical trial success.

Iyer, Rashi; Harris, Jennifer

2014-09-29T23:59:59.000Z

413

Human Capital Management | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Human Capital Management Human Capital Management Human Capital Management The strategic management of human capital requires comprehensive planning and analysis in order to develop, implement, and evaluate programs that support every facet of employee work life. DOE human capital initiatives are designed to support continuous improvement and accountability in accordance with the DOE Human Capital Management Accountability Program (HCMAP), which is an internal DOE audit process of servicing human resources offices and addresses those documents that require coordination with the Office of the Chief Human Capital Officer before being implemented; Human Resource Directors; the Department's 5-year Strategic Human Capital Management Plan; Departmental element workforce plans; the Department's personnel accountability program that is used

414

Quantifying murine bone marrow and blood radiation dose response following 18F-FDG PET with DNA damage biomarkers  

Science Journals Connector (OSTI)

Abstract The purpose of this study was to quantify the poorly understood radiation doses to murine bone marrow and blood from whole-body fluorine 18 (18F)-fluorodeoxyglucose (FDG) positron emission tomography (PET), by using specific biomarkers and comparing with whole body external low dose exposures. Groups of 3–5 mice were randomly assigned to 10 groups, each receiving either a different activity of 18F-FDG: 0–37 MBq or whole body irradiated with corresponding doses of 0–300 mGy X-rays. Blood samples were collected at 24 h and at 43 h for reticulocyte micronucleus assays and QPCR analysis of gene expression in peripheral blood leukocytes. Blood and bone marrow dose estimates were calculated from injected activities of 18F-FDG and were based on a recommended ICRP model. Doses to the bone marrow corresponding to 33.43 mGy and above for internal 18F-FDG exposure and to 25 mGy and above for external X-ray exposure, showed significant increases in radiation-induced MN-RET formation relative to controls (P dose–responses at 24 h for Bbc3 and Cdkn1 were similar for 18F-FDG and X-ray exposures, with significant modifications occurring for doses over 300 mGy for Bbc3 and at the lower dose of 150 mGy for Cdkn1a. Both leucocyte gene expression and quantification of MN-RET are highly sensitive biomarkers for reliable estimation of the low doses delivered in vivo to, respectively, blood and bone marrow, following 18F-FDG PET.

Grainne Manning; Kristina Taylor; Paul Finnon; Jennifer A. Lemon; Douglas R. Boreham; Christophe Badie

2014-01-01T23:59:59.000Z

415

THE HUMAN GENOME & GENETIC DISEASES MED263: Bioinformatic Applications to Human Disease  

E-Print Network [OSTI]

you will learn. History of the human genome project Structure and content of the human genome HapTHE HUMAN GENOME & GENETIC DISEASES MED263: Bioinformatic Applications to Human Disease #12;WhatMap project Categories of Human Disease: Monogenic (Single gene disorders) Multigenic (Complex disorders

Gleeson, Joseph G.

416

Purification and Partial Characterization of a Mr 52,000 Glycoprotein from Human Cancer Ascites Fluid Which Stimulates Bone Resorption in Vitro  

Science Journals Connector (OSTI)

...paper describes the purification and partial characterization...was purchased from Waters Associates, Milford...Precipitation. All purification procedures were carried...during the course of the purification were dialyzed twice...once against distilled water, lyophilized, and...

Mark S. Lamkin; Craig Colclasure; Weldon S. Lloyd; Jane M. Doherty; Wayne Gonnerman; Karl Schmid; and Richard B. Nimberg

1986-09-01T23:59:59.000Z

417

Elimination of B-Lymphoma Cells from Human Bone Marrow: Model Experiments Using Monodisperse Magnetic Particles Coated with Primary Monoclonal Antibodies  

Science Journals Connector (OSTI)

...particles have a diameter of 4.5 ion and a surface area of 3 to 5 m2 per g, and they contain 20% iron in the form of 7-Fe2O3. The preparation contains 1.4 x 10' particles per g. The surface of the particle is partly hydrophobic, allowing antibodies...

Gunnar Kvalheim; Øystein Fodstad; Alexander Pihl; Kjell Nustad; Anne Pharo; John Ugelstad; Steinar Funderud

1987-02-01T23:59:59.000Z

418

WILD PIG ATTACKS ON HUMANS  

SciTech Connect (OSTI)

Attacks on humans by wild pigs (Sus scrofa) have been documented since ancient times. However, studies characterizing these incidents are lacking. In an effort to better understand this phenomenon, information was collected from 412 wild pig attacks on humans. Similar to studies of large predator attacks on humans, data came from a variety of sources. The various attacks compiled occurred in seven zoogeographic realms. Most attacks occurred within the species native range, and specifically in rural areas. The occurrence was highest during the winter months and daylight hours. Most happened under non-hunting circumstances and appeared to be unprovoked. Wounded animals were the chief cause of these attacks in hunting situations. The animals involved were typically solitary, male and large in size. The fate of the wild pigs involved in these attacks varied depending upon the circumstances, however, most escaped uninjured. Most human victims were adult males traveling on foot and alone. The most frequent outcome for these victims was physical contact/mauling. The severity of resulting injuries ranged from minor to fatal. Most of the mauled victims had injuries to only one part of their bodies, with legs/feet being the most frequent body part injured. Injuries were primarily in the form of lacerations and punctures. Fatalities were typically due to blood loss. In some cases, serious infections or toxemia resulted from the injuries. Other species (i.e., pets and livestock) were also accompanying some of the humans during these attacks. The fates of these animals varied from escaping uninjured to being killed. Frequency data on both non-hunting and hunting incidents of wild pig attacks on humans at the Savannah River Site, South Carolina, showed quantitatively that such incidents are rare.

Mayer, J.

2013-04-12T23:59:59.000Z

419

Acoustics as a Human Science  

Science Journals Connector (OSTI)

There was a time when acoustics was only a human science but this changed as philosophers learned to use mathematical and other measurement tools for ordering and validating their thought processes. This century has seen many changes in the description of the field as a whole and the human aspects continue to be among the most perplexing. The highlights of accomplishments to date some observations on our current status of knowledge and some projections into the future are presented for your entertainment—if not for your information.

S. S. Stevens

1972-01-01T23:59:59.000Z

420

Iris Recognition for Human Identification  

Science Journals Connector (OSTI)

Iris recognition system is the biometric identification system. Iris has an intricate structure uniqueness stability and natural protection. Due to these features of the iris it can be used for biometric identification. This system gives better performance than other biometric identification systems. A novel eyelash removal method for preprocessing of human iris images in a human iris recognition system is presented.. Discrete cosine transform (DCT) method is used for feature extraction. For matching of two?iris code Hamming distance calculation is used. EER value must be less for the optimum performance of the system.

Lajari Alandkar; Sachin Gengaje

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

The Psychology of Human Behavior  

Science Journals Connector (OSTI)

... THE author of “The Psychology of Human Behavior” is to be congratulated on the production of an extremely readable ... congratulated on the production of an extremely readable and well-constructed elementary text-book of psychology. The addition of questions for discussion at the end of each chapter is a ...

1936-11-14T23:59:59.000Z

422

Biodiversity in Human-Impacted  

E-Print Network [OSTI]

1 #12;1 Biodiversity in Human-Impacted Landscapes Biodiversidad en Paisajes Intervenidos Volumen-1 complex and dynamic. Traditionally, efforts to protect biodiversity and address environmental problems abilities of policy makers and on-the-ground practitioners is essential to biodiversity conservation

Haller, Gary L.

423

EMERGENCY HIRE GUIDELINES HUMAN RESOURCES  

E-Print Network [OSTI]

EMERGENCY HIRE GUIDELINES HUMAN RESOURCES Workforce Planning · One Washington Square · San José, Ca: Workforce Planning; Sr. Workforce Planning Analyst DATE: May 2, 2008 I. PURPOSE / DESCRIPTION The Emergency. B. The Workforce Planning Analyst will work with the hiring manager/HR contact to identify and hire

Su, Xiao

424

Reverse engineering the human brain  

Science Journals Connector (OSTI)

...Thompson Reverse engineering the human brain Vincent Walsh Department of Experimental...can be used to temporarily prevent the brain from carrying out some of its normal functions...outline some of the advances in understanding brain function made by using TMS, and, in particular...

2000-01-01T23:59:59.000Z

425

Cognitive Engineering Automation and Human  

E-Print Network [OSTI]

· Home automation · Robotics · Unmanned vehicles (UAVs and UGVs) · Drug design/Molecular geneticsCognitive Engineering PSYC 530 Automation and Human Performance Raja Parasuraman #12;Overview Automation-Related Accidents Levels and Stages of Automation Information Acquisition and Analysis Decision

Parasuraman, Raja

426

NCSU Human Resources Training & Organizational  

E-Print Network [OSTI]

2011 NCSU Human Resources Training & Organizational Development Spring & Summer 2011 Learning to Training & Organizational Development's new eLearning Training Catalog. This catalog serves as a central information regarding: Participating Units and Who To Contact Certificate Programs Courses and Sessions eLearning

427

A human body analysis system  

Science Journals Connector (OSTI)

This paper describes a system for human body analysis (segmentation, tracking, face/hands localisation, posture recognition) from a single view that is fast and completely automatic. The system first extracts low-level data and uses part of the data ...

Vincent Girondel; Laurent Bonnaud; Alice Caplier

2006-01-01T23:59:59.000Z

428

Human Cognitive Neuropsychology PROGRAMME HANDBOOK  

E-Print Network [OSTI]

, but the handbook does not form part of any contract between University and student. 1. Arrival and OrientationMSc/Dip in Human Cognitive Neuropsychology PROGRAMME HANDBOOK 2011/2012 Psychology School) the University Regulations, (b) the Code of Practice, and (c) the Taught Masters Handbook for the School

Edinburgh, University of

429

Mesenchymal Stem Cell Transplantation to Promote Bone Healing Chan Gao,1,2  

E-Print Network [OSTI]

in humans. The objective of the current study was to deter- mine if transplantation of mesenchymal stromal performed on reasonably young, active recipients in the past two decades have used implants with porous individuals as a result of treatment for cancer or graft versus host disease.5 The majority of joint

Buschmann, Michael

430

Contractor Human Resources | National Nuclear Security Administration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Contractor Human Resources | National Nuclear Security Administration Contractor Human Resources | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Contractor Human Resources Home > About Us > Our Operations > Acquisition and Project Management > Contractor Human Resources Contractor Human Resources Welcome The Contractor Human Resources mission is to provide expert advice and

431

Mechanosensitivity of human osteosarcoma cells and phospholipase C {beta}2 expression  

SciTech Connect (OSTI)

Bone adapts to mechanical load by osteosynthesis, suggesting that osteoblasts might respond to mechanical stimuli. We therefore investigated cell proliferation and phospholipase C (PLC) expression in osteoblasts. One Hertz uniaxial stretching at 4000 {mu}strains significantly increased the proliferation rates of human osteoblast-like osteosarcoma cell line MG-63 and primary human osteoblasts. However, U-2/OS, SaOS-2, OST, and MNNG/HOS cells showed no significant changes in proliferation rate. We investigated the expression pattern of different isoforms of PLC in these cell lines. We were able to detect PLC {beta}1, {beta}3, {gamma}1, {gamma}2, and {delta}1 in all cells, but PLC {beta}2 was only detectable in the mechanosensitive cells. We therefore investigated the possible role of PLC {beta}2 in mechanotransduction. Inducible antisense expression for 24 h inhibited the translation of PLC {beta}1 in U-2/OS cells by 35% and PLC {beta}2 in MG-63 by 29%. Fluid shear flow experiments with MG-63 lacking PLC {beta}2 revealed a significantly higher level of cells losing attachment to coverslips and a significantly lower number of cells increasing intracellular free calcium.

Hoberg, M. [Department of Orthopaedics, University of Tuebingen (Germany)]. E-mail: Maik.Hoberg@med.uni-tuebingen.de; Gratz, H.-H. [Experimental Orthopaedics and Biomechanics, Phillips-University of Marburg (Germany); Noll, M. [Experimental Orthopaedics and Biomechanics, Phillips-University of Marburg (Germany); Jones, D.B. [Experimental Orthopaedics and Biomechanics, Phillips-University of Marburg (Germany)

2005-07-22T23:59:59.000Z

432

Associations between ambient air pollution and bone turnover markers in 10-year old children: Results from the \\{GINIplus\\} and \\{LISAplus\\} studies  

Science Journals Connector (OSTI)

Abstract Negative associations between bone turnover markers and bone mineral density have been reported. In order to study the association between ambient air pollution and bone turnover markers, as indicators of bone loss, we investigated associations between land-use regression modeled air pollution (NO2, PM2.5 mass, PM2.5 – 10 [coarse particles], PM10 mass and PM2.5 absorbance) and bone turnover markers in 2264 children aged 10 years. Serum osteocalcin and C-terminal telopeptide of type I collagen (CTx), measured by Modular-System (Roche), were the two bone turnover markers considered in this analysis. In total population, NO2, PM2.5 – 10 and PM10 mass exposure were positively and significantly associated with both osteocalcin and CTx. A 2.5 (95% CI: 0.6, 4.4) ng/ml increase in osteocalcin and a 24.0 (95% CI: 6.7, 41.3) ng/L increase in \\{CTx\\} were observed per IQR (6.7 ?g/m3) increase in NO2, independent of socioeconomic status, sex, age, pubertal status, fasting status and total physical activity. The estimated coefficients were 3.0 (95% CI: 0.1, 5.8) for osteocalcin and 32.3 (95% CI: 6.1, 58.5) for \\{CTx\\} with PM2.5 – 10; 3.2 (95% CI: 0.0, 6.4) for osteocalcin and 30.7 (95% CI: 1.7, 59.7) for \\{CTx\\} with PM10. Children living close to a major road (? 350 m) had higher levels of both osteocalcin (1.4 [?1.2, 4.0] ng/ml) and \\{CTx\\} (16.2 [?7.4, 39.8] ng/L). The adverse impact of ambient air pollution on bone turnover rates observed in one of the study areas showed stimulation of more such studies.

Chuang Liu; Elaine Fuertes; Claudia Flexeder; Lorenz C. Hofbauer; Dietrich Berdel; Barbara Hoffmann; Jürgen Kratzsch; Andrea von Berg; Joachim Heinrich

2015-01-01T23:59:59.000Z

433

Patterns of Practice in Palliative Radiotherapy for Painful Bone Metastases: A Survey in Japan  

SciTech Connect (OSTI)

Purpose: To determine the current patterns of practice in Japan and to investigate factors that may make clinicians reluctant to use single-fraction radiotherapy (SF-RT). Methods and Materials: Members of the Japanese Radiation Oncology Study Group (JROSG) completed an Internet-based survey and described the radiotherapy dose fractionation they would recommend for four hypothetical cases describing patients with painful bone metastasis (BM). Case 1 described a patient with an uncomplicated painful BM in a non-weight-bearing site from non-small-cell lung cancer. Case 2 investigated whether management for a case of uncomplicated spinal BM would be different from that in Case 1. Case 3 was identical with Case 2 except for the presence of neuropathic pain. Case 4 investigated the prescription for an uncomplicated painful BM secondary to oligometastatic breast cancer. Radiation oncologists who recommended multifraction radiotherapy (MF-RT) for Case 2 were asked to explain why they considered MF-RT superior to SF-RT. Results: A total of 52 radiation oncologists from 50 institutions (36% of JROSG institutions) responded. In all four cases, the most commonly prescribed regimen was 30 Gy in 10 fractions. SF-RT was recommended by 13% of respondents for Case 1, 6% for Case 2, 0% for Case 3, and 2% for Case 4. For Case 4, 29% of respondents prescribed a high-dose MF-RT regimen (e.g., 50 Gy in 25 fractions). The following factors were most often cited as reasons for preferring MF-RT: 'time until first increase in pain' (85%), 'incidence of spinal cord compression' (50%), and 'incidence of pathologic fractures' (29%). Conclusions: Japanese radiation oncologists prefer a schedule of 30 Gy in 10 fractions and are less likely to recommend SF-RT. Most Japanese radiation oncologists regard MF-RT as superior to SF-RT, based primarily on the time until first increase in pain.

Nakamura, Naoki, E-mail: naokinak@luke.or.jp [Department of Radiation Oncology, St. Luke's International Hospital, Tokyo (Japan); Shikama, Naoto [Department of Radiation Oncology, Saitama Medical University International Medical Center, Hidaka (Japan); Wada, Hitoshi [Department of Radiation Oncology, Miyagi Cancer Center, Natori (Japan); Harada, Hideyuki [Division of Radiation Oncology, Shizuoka Cancer Center, Mishima (Japan); Nozaki, Miwako [Department of Radiology, Dokkyo Medical University Koshigaya Hospital, Koshigaya (Japan); Nagakura, Hisayasu [Department of Radiology, KKR Sapporo Medical Center, Sapporo (Japan); Tago, Masao [Department of Radiology, Teikyo University Mizonokuchi Hospital, Kawasaki (Japan); Oguchi, Masahiko [Department of Radiation Oncology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo (Japan); Uchida, Nobue [Department of Radiation Oncology, Shimane University Hospital, Izumo (Japan)

2012-05-01T23:59:59.000Z

434

Synthesizing Human Motion from Intuitive Constraints  

Science Journals Connector (OSTI)

Many compelling applications would become feasible if novice users had the ability to synthesize high quality human motion based only on a simple sketch and ... proven to be a powerful tool for synthesizing human motion

Alla Safonova; Jessica K. Hodgins

2008-01-01T23:59:59.000Z

435

Human adaptation of avian influenza viruses  

E-Print Network [OSTI]

Human adaptation of avian influenza viruses pose an enormous public health challenge as the human population is predominantly naive to avian influenza antigens. As such, constant surveillance is needed to monitor the ...

Srinivasan, Karunya

2012-01-01T23:59:59.000Z

436

What Does It Mean to Be Human?  

Science Journals Connector (OSTI)

Humans are the highest form of intelligent life on Earth. But what is it that makes us distinctly human? From a purely scientific perspective, what, if anything, sets us apart from other forms of life? Are the...

Barry B. Luokkala

2014-01-01T23:59:59.000Z

437

Propeller based human powered swimming device  

E-Print Network [OSTI]

Currently the only human powered swimming device widely sold on the market are swim flippers. However, flippers are not efficient for the human body, and there is a potential to increase the speed while swimming with a ...

Bunker, Kristine (Kristine Alina)

2014-01-01T23:59:59.000Z

438

Video looping of human cyclic motion  

E-Print Network [OSTI]

In this thesis, a system called Video Looping is developed to analyze human cyclic motions. Video Looping allows users to extract human cyclic motion from a given video sequence. This system analyzes similarities from a large amount of live footage...

Choi, Hye Mee

2004-09-30T23:59:59.000Z

439

Human Brain vs. Computer | GE Global Research  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Computer Processors Beat the Human Mind in the Future? Can Computer Processors Beat the Human Mind in the Future? 2013.01.29 Chief Scientist Jim Bray takes on this question that...

440

6.20 Mapping Human Brain Function  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

0 612011 6.20 Mapping Human Brain Function Many mysteries of the human brain have been unraveled by positron emission tomography (PET), an imaging tool used worldwide to diagnose...

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Workshop Reports Understanding Paleoclimate and Human Evolution  

E-Print Network [OSTI]

, involving research in anthropology, archaeology, human genetics and genomics, and the earth sciences resolved paleoenvironmental information. This concept is not new. Almost thirty years ago, the U.SWorkshop Reports Understanding Paleoclimate and Human Evolution Through the Hominin Sites

Reiners, Peter W.

442

In Vitro Perfused Human Capillary Networks  

E-Print Network [OSTI]

during vessel network formation, micro- spheres traversedof a living network of dynamic human capillaries in a micro-

Moya, Monica L.; Hsu, Yu-Hsiang; Lee, Abraham P.; Hughes, Christopher C.W.; George, Steven C.

2013-01-01T23:59:59.000Z

443

Careers/ Human Resources | Princeton Plasma Physics Lab  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Employment Opportunities Environment, Safety & Health Procurement Division Technology Transfer Furth Plasma Physics Library Contact Us Lab Leadership Directory Careers Human...

444

GDB - Human Genome Database final report  

SciTech Connect (OSTI)

This is the DOE final report for the GDB, Human Genome Database, project at the Johns Hopkins University.

Talbot, C. Conover, Jr.

2002-01-08T23:59:59.000Z

445

2014 DOE Human Reliability Program (HRP) Workshop | Department...  

Office of Environmental Management (EM)

DOE Human Reliability Program (HRP) Workshop 2014 DOE Human Reliability Program (HRP) Workshop August 18, 2014 - 7:51am Addthis 2014 DOE Human Reliability Program (HRP) Workshop...

446

PIA - Human Resources Management System | Department of Energy  

Office of Environmental Management (EM)

System PIA - Human Resources Management System More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - Human Resources - Personal Information Change...

447

Contractor Human Resource Management Programs  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This directive establishes DOE responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. DOE O 350.1 Chg 5, dated 9-30-2014, cancels Chapters I-III of DOE O 350.1 Chg 4

1996-09-29T23:59:59.000Z

448

Contractor Human Resource Management Programs  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

The purpose of this directive is to establish Department of Energy (DOE) responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. This order cancels DOE O 3220.1A, DOE O 3220.4A, DOE O 3220.6A, and DOE O 3309.1A.

1996-09-30T23:59:59.000Z

449

Learning Human Motion Models Bulent Tastan  

E-Print Network [OSTI]

Learning Human Motion Models Bulent Tastan Department of EECS University of Central Florida Orlando In this summary, I provide an overview of my disserta- tion work on learning human motion models from trajectory) pursuing opponents. Human Tracking One of the most powerful constraints governing many ac- tivity

Sukthankar, Gita Reese

450

Policy Title: Human Subject Responsible Office: UFS  

E-Print Network [OSTI]

Policy Title: Human Subject Payments Responsible Office: UFS HARVARD UNIVERSITY FINANCIAL POLICY Effective Date: 1/1/11 Revision Date: N/A HUMAN SUBJECT PAYMENTS Policy Number TAX102 HARVARD UNIVERSITY FINANCIAL POLICY POLICY STATEMENT Individuals conducting Harvard research studies that compensate human

Chen, Yiling

451

Casein Production by Human Breast Cancer  

Science Journals Connector (OSTI)

...human breast cancers. Casein production by human breast cancer...Thus it appears that casein production is not a common characteristic...magnesium, by scraping with a rubber policeman and collected by...sulfate. MARCH 1977 749 Casein Production by Human Breast Cancer Marie...

Marie E. Monaco; Diane A. Bronzert; Douglass C. Tormey; Phillip Waalkes; and Marc E. Lippman

1977-03-01T23:59:59.000Z

452

INVESTIGATION Inferring Admixture Histories of Human Populations  

E-Print Network [OSTI]

and apply to test for admixture among all populations from the Human Genome Diversity Project (HGDPINVESTIGATION Inferring Admixture Histories of Human Populations Using Linkage Disequilibrium Po-range migrations and the resulting admixtures between populations have been important forces shaping human genetic

Reich, David

453

Genomic Comparisons of Humans and Chimpanzees  

E-Print Network [OSTI]

Genomic Comparisons of Humans and Chimpanzees Ajit Varki1 and David L. Nelson2 1 Glycobiology to human evolution, development, and disease. Sequence differences from the human genome were confirmed in the sidebar Online Sources of Information Regarding the Chimpanzee Genome. At the outset, we also emphasize

454

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES The College of Architecture, Arts and Humanities offers graduate programs in three schools: the School in Architecture; City and Regional Planning; Construction Science and Management; Digital Pro- duction Arts

Stuart, Steven J.

455

College of Architecture, Arts and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

25 College of Architecture, Arts and Humanities COLLEGE OF ARCHITECTURE, ARTS AND HUMANITIES The College of Architecture, Arts and Humanities offers graduate programs in three schools: the School in Architecture; City and Regional Planning; Construction Science and Management; Digital Pro- duction Arts

Stuart, Steven J.

456

College of Architecture, Arts, and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

56 College of Architecture, Arts, and Humanities 56 COLLEGE OF ARCHITECTURE, ARTS, AND HUMANITIES The collaboration of Architecture (Landscape Ar- chitecture, Construction Science and Management, City and Regional Planning, and Architecture) with Arts (Visual Arts and Performing Arts) and the Humanities (Communication

Stuart, Steven J.

457

College of Architecture, Arts, and Humanities ARCHITECTURE,  

E-Print Network [OSTI]

57 College of Architecture, Arts, and Humanities COLLEGE OF ARCHITECTURE, ARTS, AND HUMANITIES The collaboration of Architecture (Landscape Ar- chitecture, Construction Science and Management, City and Regional Planning, and Architecture) with Arts (Visual Arts and Performing Arts) and the Humanities (Communication

Stuart, Steven J.

458

The need for a human gene index  

Science Journals Connector (OSTI)

......need for a human gene index. | Editorial | Abstracting...NEED FOR A HUMAN GENE INDEX Much noise has been made...the year 2000 about the completion of a "draft" of the...changes in assembly and completion of the draft genome...need for a human gene index Towards a true gene index......

C. Victor Jongeneel

2000-12-01T23:59:59.000Z

459

Reflections on the human prospect  

SciTech Connect (OSTI)

World population and the global economy are expanding in a manner that is propelling civilization along a path that is unsustainable, inequitable, and unstable. A concerted, global effort to discover, integrate, disseminate, and apply knowledge about the natural world and human behavior would change this trajectory to a path of sustainable human development. This path would point toward the vision of a society in which the basic human needs and an equitable share of life`s amenities could be met by successive generations while maintaining in perpetuity a health, physically attractive, and biologically productive environment. The scholarly community is urged to provide impetus for the pursuit of this vision. An unprecedented degree of collaboration among the disciplines will be necessary. New modes of communication and cooperation among the major sectors of society will have to be fashioned. Knowledge will become an organizing principle for society in the twenty-first century. Climate change has resulted from continuing economic and demographic growth. To stabilize world climate, the emission of greenhouse gases must be controlled. 57 refs.

Malone, T.F. [Sigma Xi Center, Research Triangle Park, NC (United States); [North Carolina State Univ., Raleigh, NC (United States)

1995-11-01T23:59:59.000Z

460

Research on digital human model used in human factor simulation and evaluation of load carriage equipment  

Science Journals Connector (OSTI)

Data structure of the digital human model has been constructed for particularity demand of human factor evaluation of the load carriage system equipments. Anthropometry data of different percentage was obtained through regression calculation; Range of ... Keywords: digital human model, human factors, load carriage equipment, simulation

Dayong Dong; Lijing Wang; Xiugan Yuan; Shan Fu

2011-07-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

Interactive Manipulation Between a Human and a Humanoid: When Robots Control Human Arm Motion  

E-Print Network [OSTI]

Interactive Manipulation Between a Human and a Humanoid: When Robots Control Human Arm Motion Bruno a novel approach in human/robot collaboration, where the robot controls not only its arm but also our previous framework [5] to the case where the robot controls both its arm and the human's in order

Boyer, Edmond

462

The Humanity of the Human Body: Is Homo Cybersapien a New Species?  

Science Journals Connector (OSTI)

The importance of the human body within traditional bioethical debates is amplified within the field of technoethics as scholars attempt to grapple with conflicting views of what it means to be human and what attributes are core to human beings within ... Keywords: Freedom, Human Body, Modernity, Postmodernity, Science, Technoethics

Rocci Luppicini; José M. Galván

2012-04-01T23:59:59.000Z

463

The LIRIS Human activities dataset and the ICPR 2012 human activities recognition and localization competition  

E-Print Network [OSTI]

The LIRIS Human activities dataset and the ICPR 2012 human activities recognition and localization-69621, France March 28, 2012 Abstract We describe the LIRIS human activities dataset, the dataset used competitions and existing datasets, the tasks focus on complex human behavior involving several people

Wolf, Christian

464

Climate Human Capital | Open Energy Information  

Open Energy Info (EERE)

Climate Human Capital Climate Human Capital Jump to: navigation, search Name Climate Human Capital Place London, United Kingdom Zip W1K 6NG Sector Carbon, Renewable Energy, Services Product Green executive search company, listed in London's PLUS marketplace since 30 MArch 2010, focusing on the following target sectors: Carbon Markets, Environmental Sciences, Research and Advisory, Financial Services, Renewable Energy Generation and Policy. References Climate Human Capital[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Climate Human Capital is a company located in London, United Kingdom . References ↑ "Climate Human Capital" Retrieved from "http://en.openei.org/w/index.php?title=Climate_Human_Capital&oldid=343709

465

Oxidized low density lipoprotein increases RANKL level in human vascular cells. Involvement of oxidative stress  

SciTech Connect (OSTI)

Highlights: •Oxidized LDL enhances RANKL level in human smooth muscle cells. •The effect of OxLDL is mediated by the transcription factor NFAT. •UVA, H{sub 2}O{sub 2} and buthionine sulfoximine also increase RANKL level. •All these effects are observed in human fibroblasts and endothelial cells. -- Abstract: Receptor Activator of NF?B Ligand (RANKL) and its decoy receptor osteoprotegerin (OPG) have been shown to play a role not only in bone remodeling but also in inflammation, arterial calcification and atherosclerotic plaque rupture. In human smooth muscle cells, Cu{sup 2+}-oxidized LDL (CuLDL) 10–50 ?g/ml increased reactive oxygen species (ROS) and RANKL level in a dose-dependent manner, whereas OPG level was not affected. The lipid extract of CuLDL reproduced the effects of the whole particle. Vivit, an inhibitor of the transcription factor NFAT, reduced the CuLDL-induced increase in RANKL, whereas PKA and NF?B inhibitors were ineffective. LDL oxidized by myeloperoxidase (MPO-LDL), or other pro-oxidant conditions such as ultraviolet A (UVA) irradiation, incubation with H{sub 2}O{sub 2} or with buthionine sulfoximine (BSO), an inhibitor of glutathione synthesis{sub ,} also induced an oxidative stress and enhanced RANKL level. The increase in RANKL in pro-oxidant conditions was also observed in fibroblasts and endothelial cells. Since RANKL is involved in myocardial inflammation, vascular calcification and plaque rupture, this study highlights a new mechanism whereby OxLDL might, by generation of an oxidative stress, exert a deleterious effect on different cell types of the arterial wall.

Mazière, Cécile, E-mail: maziere.cecile@chu-amiens.fr [Biochemistry Laboratory, South Hospital University, René Laennec Avenue, Amiens 80000 (France)] [Biochemistry Laboratory, South Hospital University, René Laennec Avenue, Amiens 80000 (France); Salle, Valéry [Internal Medicine, North Hospital University, Place Victor Pauchet, Amiens 80000 (France) [Internal Medicine, North Hospital University, Place Victor Pauchet, Amiens 80000 (France); INSERM U1088 (EA 4292), SFR CAP-Santé (FED 4231), University of Picardie – Jules Verne (France); Gomila, Cathy; Mazière, Jean-Claude [Biochemistry Laboratory, South Hospital University, René Laennec Avenue, Amiens 80000 (France)] [Biochemistry Laboratory, South Hospital University, René Laennec Avenue, Amiens 80000 (France)

2013-10-18T23:59:59.000Z

466

PIA - INL PeopleSoft - Human Resource System | Department of...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

PIA - INL PeopleSoft - Human Resource System PIA - INL PeopleSoft - Human Resource System PIA - INL PeopleSoft - Human Resource System PIA - INL PeopleSoft - Human Resource System...

467

Human Resources & Occupational Medicine  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Job Opportunities Benefits Office • Work-Life Balance Programs • International Services • Occupational Medicine • Salaries & Awards • Training & Qualifications The Human Resources and Occupational Medicine Division handles scientific and non-scientific employment, benefits, employee and labor relations, staff development, salaries and awards, employee records, and occupational medicine. For more information, click on the one of the services listed above. Brookhaven National Laboratory has a long-standing commitment to a policy of equal opportunity and diversity. Our goal is equality of opportunity in all aspects of employment, including placement, development programs, job assignments, transfers and promotions, without regard to race, color,

468

Simulation of human decision making  

DOE Patents [OSTI]

A method for computer emulation of human decision making defines a plurality of concepts related to a domain and a plurality of situations related to the domain, where each situation is a combination of at least two of the concepts. Each concept and situation is represented in the computer as an oscillator output, and each situation and concept oscillator output is distinguishable from all other oscillator outputs. Information is input to the computer representative of detected concepts, and the computer compares the detected concepts with the stored situations to determine if a situation has occurred.

Forsythe, J. Chris (Sandia Park, NM); Speed, Ann E. (Albuquerque, NM); Jordan, Sabina E. (Albuquerque, NM); Xavier, Patrick G. (Albuquerque, NM)

2008-05-06T23:59:59.000Z

469

Contractor Human Resource Management Programs  

Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

This directive establishes DOE responsibilities and requirements for the management and oversight of contractor Human Resource Management (HR) programs. Chg 1, 5-8-98; Chg 2, 11-22-09; Chg 3, 2-23-10; Chg 4, 4-29-13. DOE O 350.1 Chg 5, dated 9-30-2014, cancels DOE O 350.1 Chg 4. The Order is revised to reflect the cancellation of Chapters 1-3 due to the incorporation of these chapters into DOE Order 350.3; reflect organizational changes; delete reference to the DOE Retrospective Rating Insurance Plan, which is no longer available; remove the CRD from Chapter VII.

1996-09-30T23:59:59.000Z

470

ToF-SIMS evaluation of calcium-containing silica/?-PGA hybrid systems for bone regeneration  

Science Journals Connector (OSTI)

Abstract Inorganic/organic hybrids have great potential for the production of bioactive scaffolds which have tailored mechanical properties and degradation rates suitable for tissue engineering. For bone regeneration, calcium incorporation into hybrids at low temperatures is important due to its ability to stimulate new bone formation. As a consequence, understanding the homogeneity of the critical inorganic and organic components will be the key to the development of such hybrids. The aim of this interdisciplinary study was to use time-of-flight secondary ion mass spectrometry (ToF-SIMS) to determine the homogeneity of these critical components. We evaluated various sol–gel silica/?-polyglutamic acid (?-PGA) hybrid systems produced using different routes to introduce the calcium, thereby tailoring and optimizing hybrid syntheses and processing routes. Dimethyl carbonate (DMC) was used to improve the inorganic/organic coupling and its influence on the homogeneity of the hybrid structures was also examined. The results revealed that the calcium salt form of ?-PGA was promising for calcium incorporation since homogeneous products could be obtained. The ToF-SIMS data also indicated that the reaction time of hybrid synthesis and the timing of the addition of DMC can affect the homogeneity of hybrids.

Daming Wang; Jin Nakamura; Gowsihan Poologasundarampillai; Toshihiro Kasuga; Julian R. Jones; David S. McPhail

2014-01-01T23:59:59.000Z

471

Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium  

E-Print Network [OSTI]

†, [8,9] Carrie Nielson, [10] Priya Srikanth, [10] Sylvie Giroux, [11] Scott G Wilson, [2,12,13] Hou-Feng Zheng, [14] Albert V Smith, [15,16] Stephen R Pye, [17] Paul J Leo, [18] Alexander Teumer, [19] Joo-Yeon Hwang, [20] Claes Ohlsson, [21] Fiona Mc... Email: stephen@srl.cam.ac.uk Tel : +44 1223 748668 Fax: +44 1223 748658 5   ABSTRACT Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by x...

Moayyeri, Alireza; Hsu, Yi-Hsiang; Karasik, David; Estrada, Karol; Xiao, Su-Mei; Nielson, Carrie; Srikanth, Priya; Giroux, Sylvie; Wilson, Scott G.; Zheng, Hou-Feng; Smith, Albert V.; Pye, Stephen R.; Leo, Paul J.; Teumer, Alexander; Hwang, Joo-Yeon; Ohlsson, Claes; McGuigan, Fiona; Minster, Ryan L.; Hayward, Caroline; Olmos, José M.; Lyytikäinen, Leo-Pekka; Lewis, Joshua R.; Swart, Karin M. A.; Masi, Laura; Oldmeadow, Chris; Holliday, Elizabeth G.; Cheng, Sulin; van Schoor, Natasja M.; Harvey, Nicholas C.; Kruk, Marcin; Del Greco M, Fabiola; Igl, Wilmar; Trummer, Olivia; Grigoriou, Efi; Luben, Robert; Liu, Ching-Ti; Zhou, Yanhua; Oei, Ling; Medina-Gomez, Carolina; Zmuda, Joseph; Tranah, Greg; Brown, Suzanne J.; Williams, Frances M.; Soranzo, Nicole; Jakobsdottir, Johanna; Siggeirsdottir, Kristin; Holliday, Kate L.; Hannemann, Anke; Go, Min Jin; Garcia, Melissa; Polasek, Ozren; Laaksonen, Marika; Zhu, Kun; Enneman, Anke W.; McEvoy, Mark; Peel, Roseanne; Sham, Pak Chung; Jaworski, Maciej; Johansson, Åsa; Hicks, Andrew A.; Pludowski, Pawel; Scott, Rodney; Dhonukshe-Rutten, Rosalie A. M.; van der Velde, Nathalie; Kähönen, Mika; Viikari, Jorma S.; Sievänen, Harri; Raitakari, Olli T.; González-Macías, Jesús; Hernández, Jose L.; Mellström, Dan; Ljunggren, Östen; Cho, Yoon Shin; Völker, Uwe; Nauck, Matthias; Homuth, Georg; Völzke, Henry; Haring, Robin; Brown, Matthew A.; McCloskey, Eugene; Nicholson, Geoffrey C.; Eastell, Richard; Eisman, John A.; Jones, Graeme; Reid, Ian R.; Dennison, Elaine M.; Wark, John; Boonen, Steven; Vanderschueren, Dirk; Wu, Frederick C. W.; Aspelund, Thor; Richards, J. Brent; Bauer, Doug; Hofman, Albert; Khaw, Kay-Tee; Dedoussis, George; Obermayer-Pietsch, Barbara; Gyllensten, Ulf; Pramstaller, Peter P.; Lorenc, Roman S.; Cooper, Cyrus; Kung, Annie Wai Chee; Lips, Paul; Alen, Markku; Attia, John; Brandi, Maria Luisa; de Groot, Lisette C. P. G. M.; Lehtimäki, Terho; Riancho, José A.; Campbell, Harry; Liu, Yongmei; Harris, Tamara B.; Akesson, Kristina; Karlsson, Magnus; Lee, Jong-Young; Wallaschofski, Henri; Duncan, Emma L.; O'Neill, Terence W.; Gudnason, Vilmundur; Spector, Timothy D.; Rousseau, François; Orwoll, Eric; Cummings, Steve; Wareham, Nick J.; Rivadeneira, Fernando; Uitterlinden, Andre G.; Prince, Richard L.; Kiel, Douglas P.; Reeve, Jonathan; Kaptoge, Stephen K.

2014-01-14T23:59:59.000Z

472

Solar radiation and human health  

Science Journals Connector (OSTI)

The Sun has played a major role in the development of life on Earth. In Western culture, people are warned against Sun exposure because of its adverse effects: erythema, photoimmunosuppression, photoageing, photocarcinogenesis, cataracts and photokeratitis. However, Sun exposure is also beneficial, since moderate doses give beneficial physiological effects: vitamin D synthesis, reduction of blood pressure and mental health. Shortage of Sun exposure may be even more dangerous to human health than excessive exposure. Avoiding Sun exposure leads to vitamin D deficiency which is associated not only with rickets and osteomalacia, but also with increased risk of cardiovascular disease, multiple sclerosis, rheumatoid arthritis, diabetes, influenza, many types of cancer and adverse pregnancy outcomes. Solar radiation induces nitric oxide release in tissue and immediate pigment darkening which certainly play important roles, although these are still unknown. Action spectra relevant for health are described. We will also review what is known about spectral and intensity variations of terrestrial solar radiation as well as its penetration through the atmosphere and into human skin and tissue.

Asta Juzeniene; Pål Brekke; Arne Dahlback; Stefan Andersson-Engels; Jörg Reichrath; Kristin Moan; Michael F Holick; William B Grant; Johan Moan

2011-01-01T23:59:59.000Z

473

China and the Humanities: At the Crossroads of the Human and the Humane  

E-Print Network [OSTI]

to legitimatize their own rule. However unlike the Manchu rulers, his analysis reveals only a dark portent for the future of Chinese civilization. Part Three Humanities’ Mark on People |???????? The five chapters of part three of this volume revolve around... or Virginia Woolf Academic Web] (http://globe.eworkway.com) that provides an im- portant on-line venue for Chinese academics and readers who are devoted to the life and works of Virginia Woolf. Judy LATTAS Judy Lattas is the Director of the Interdisciplinary...

Tchou, W. Kang

2013-01-01T23:59:59.000Z

474

Human Resources | National Nuclear Security Administration  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Human Resources | National Nuclear Security Administration Human Resources | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Human Resources Home > About Us > Our Operations > Management and Budget > Human Resources Human Resources The Human Resources function in NNSA is a vital partnership between all levels of NNSA management. It requires effective collaboration with the

475

Human Resources | National Nuclear Security Administration  

National Nuclear Security Administration (NNSA)

Human Resources | National Nuclear Security Administration Human Resources | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Human Resources Home > About Us > Our Operations > Management and Budget > Human Resources Human Resources The Human Resources function in NNSA is a vital partnership between all levels of NNSA management. It requires effective collaboration with the

476

Can Robots and Humans Get Along?  

SciTech Connect (OSTI)

Now that robots have moved into the mainstream—as vacuum cleaners, lawn mowers, autonomous vehicles, tour guides, and even pets—it is important to consider how everyday people will interact with them. A robot is really just a computer, but many researchers are beginning to understand that human-robot interactions are much different than human-computer interactions. So while the metrics used to evaluate the human-computer interaction (usability of the software interface in terms of time, accuracy, and user satisfaction) may also be appropriate for human-robot interactions, we need to determine whether there are additional metrics that should be considered.

Scholtz, Jean

2007-06-01T23:59:59.000Z

477

PIA - Human Resources - Personal Information Change Request ...  

Office of Environmental Management (EM)

Request - Idaho National Engineering Laboratory More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - INL SECURITY INFORMATION MANAGEMENT SYSTEM...

478

Human Health Science Building Geothermal Heat Pumps  

Broader source: Energy.gov (indexed) [DOE]

HUMAN HEALTH SCIENCE BLDG GEO HEAT PUMP SYSTEMS Principal Investigator Source Heat Pumps Demo Projects May 20, 2010 This presentation does not contain any proprietary confidential,...

479

Human Capital Management Accountability Program (HCMAP)  

Broader source: Energy.gov [DOE]

Human Capital Management Accountability Program (HCMAP) is an online program which serves as the vehicle for identifying and measuring these three factors, effectiveness, efficiency, and timeliness...

480

Apparatus and methods for a human extender  

DOE Patents [OSTI]

A human extender controller for interface between a human operator and a physical object through a physical plant. The human extender controller uses an inner-feedback loop to increase the equivalent damping of the operating system to stabilize the system when it contacts with the environment and reduces the impact of the environment variation by utilizing a high feedback gain, determined by a root locus sketch. Because the stability of the human extender controller of the present invention is greatly enhanced over that of the prior art, the present invention is able to achieve a force reflection ratio 500 to 1 and capable of handling loads above the two (2) ton range.

Jansen, John F. (Knoxville, TN)

2001-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "human cortical bone" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Essays on Human Development and Public Policy  

E-Print Network [OSTI]

52, January 2003. [54] Amartya Sen. Editorial: Human capitalapproach is advocated by Amartya Sen (1997) greater control1961, December 1997. [55] Amartya K Sen. Poverty: An ordinal

Raykar, Neha

2011-01-01T23:59:59.000Z

482

Mimicking human-drawn pencil lines.  

E-Print Network [OSTI]

??In applications such as architecture, early design sketches containing accurate line drawings often mislead the target audience [Schumann et al. 1996]. Approximate human-drawn sketches are… (more)

Al-Meraj, Zainab Faisal

2008-01-01T23:59:59.000Z

483

Description and Drawings of the Human Leg  

E-Print Network [OSTI]

. Os Cuneiform Externa. 85. Os Scaphoid. 86. A. D o r s a l i s P e d i s . 87. A. P l a n t a r i s m e d i a l i s . 88. A. L a t e r a l i s . 89. Aponeurosis p l a n t a r i s . 90. 1st metatarsal bone. 91. 5th M e t a t a r s a l bone. 92.... M. F l e x o r d i g i t o r u m b r e v i s . 90. M. Adductor H a l l u c i s . 95. F l e x o r H a l l u c i s b r e v i s . 96. M. Extensor H a l l u c i s b r e v i s . 97. M. Extensor digitorum b r e v i s . 98. Abductor d i g i t i q u i n...

Bigger, John Dinsmore

1909-01-01T23:59:59.000Z

484

Power Generation and Human Health  

Science Journals Connector (OSTI)

Emissions from power generation are associated with adverse health and ecological effects. Fossil fuel-based power plants (such as coal, oil, and to a lesser extent, natural gas) are associated with emissions of particulate matter (PM), nitrogen oxides (NOx), sulfur dioxide (SO2), and a variety of organic contaminants such as mercury and volatile organic compounds (VOCs). Exposure to emissions from power plants has been associated with a variety of respiratory symptoms, typically based on short-term (e.g., from 5–10 min to 24 h) increases in ambient concentrations. In addition, exposure to constituents from emissions generated by fossil fuels has been associated with increases in premature mortality, particularly in the elderly, and a variety of respiratory and cardiovascular illnesses. Fossil fuels, particularly coal-fired power plants, are responsible for generating the majority of emissions to which humans are exposed.

K. von Stackelberg

2011-01-01T23:59:59.000Z

485

Biofabrication of customized bone grafts by combination of additive manufacturing and bioreactor knowhow  

Science Journals Connector (OSTI)

This study reports on an original concept of additive manufacturing for the fabrication of tissue engineered constructs (TEC), offering the possibility of concomitantly manufacturing a customized scaffold and a bioreactor chamber to any size and shape. As a proof of concept towards the development of anatomically relevant TECs, this concept was utilized for the design and fabrication of a highly porous sheep tibia scaffold around which a bioreactor chamber of similar shape was simultaneously built. The morphology of the bioreactor/scaffold device was investigated by micro-computed tomography and scanning electron microscopy confirming the porous architecture of the sheep tibiae as opposed to the non-porous nature of the bioreactor chamber. Additionally, this study demonstrates that both the shape, as well as the inner architecture of the device can significantly impact the perfusion of fluid within the scaffold architecture. Indeed, fluid flow modelling revealed that this was of significant importance for controlling the nutrition flow pattern within the scaffold and the bioreactor chamber, avoiding the formation of stagnant flow regions detrimental for in vitro tissue development. The bioreactor/scaffold device was dynamically seeded with human primary osteoblasts and cultured under bi-directional perfusion for two and six weeks. Primary human osteoblasts were observed homogenously distributed throughout the scaffold, and were viable for the six week culture period. This work demonstrates a novel application for additive manufacturing in the development of scaffolds and bioreactors. Given the intrinsic flexibility of the additive manufacturing technology platform developed, more complex culture systems can be fabricated which would contribute to the advances in customized and patient-specific tissue engineering strategies for a wide range of applications.

Pedro F Costa; C?dryck Vaquette; Jeremy Baldwin; Mohit Chhaya; Manuela E Gomes; Rui L Reis; Christina Theodoropoulos; Dietmar W Hutmacher

2014-01-01T23:59:59.000Z

486

Reservoir Character of the Avalon Shale (Bone Spring Formation) of the Delaware Basin, West Texas and Southeast New Mexico: Effect of Carbonate-rich Sediment Gravity Flows  

E-Print Network [OSTI]

play is not considered to extend to the top of the first Bone Spring carbonate because hydraulic fracturing in the upper parts may penetrate overlying water-bearing units within the Delaware Mountains Group. The Avalon has been reported to range from...

Stolz, Dustin

2014-05-31T23:59:59.000Z

487

Changes in Bone Mineral, Lean Body Mass and Fat Content as Measured by Dual Energy X-ray Absorptiometry: A Longitudinal Study  

Science Journals Connector (OSTI)

Bone mineral density (BMD) and soft tissue composition were measured by dual energy X-ray absorptiometry (DXA) 3–4 years apart in 273 men and women aged 23–90. We found different rates of BMD loss in differen...

M. K. Karlsson; K. J. Obrant; B. E. Nilsson; O. Johnell

2000-02-01T23:59:59.000Z

488

Efficacy of rhBMP-2 loaded PCL/PLGA/?-TCP guided bone regeneration membrane fabricated by 3D printing technology for reconstruction of calvaria defects in rabbit  

Science Journals Connector (OSTI)

We successfully fabricated a three-dimensional (3D) printing-based PCL/PLGA/?-TCP guided bone regeneration (GBR) membrane that slowly released rhBMP-2. To impregnate the GBR membrane with intact rhBMP-2, collagen solution encapsulating rhBMP-2 (5?µg?ml?1) was infused into pores of a PCL/PLGA/?-TCP membrane constructed using a 3D printing system with four dispensing heads. In a release profile test, sustained release of rhBMP-2 was observed for up to 28?d. To investigate the efficacy of the GBR membrane on bone regeneration, PCL/PLGA/?-TCP membranes with or without rhBMP-2 were implanted in an 8?mm calvaria defect of rabbits. Bone formation was evaluated at weeks 4 and 8 histologically and histomorphometrically. A space making ability of the GBR membrane was successfully maintained in both groups, and significantly more new bone was formed at post-implantation weeks 4 and 8 by rhBMP-2 loaded GBR membranes. Interestingly, implantation with rhBMP-2 loaded GBR membranes led to almost entire healing of calvaria defects within 8?weeks.

Jin-Hyung Shim; Min-Chul Yoon; Chang-Mo Jeong; Jinah Jang; Sung-In Jeong; Dong-Woo Cho; Jung-Bo Huh

2014-01-01T23:59:59.000Z

489

HETHR -Harvard Ethics Training in Human Research Harvard Ethics Training in Human Research  

E-Print Network [OSTI]

HETHR - Harvard Ethics Training in Human Research Harvard Ethics Training in Human Research of the Harvard Ethics Training in Human Research (HETHR) curriculum. This certification is effective on 01 and the following required topics: · History · Definitions · Ethical Principles · Informed Consent · Regulations

Church, George M.

490

Decision-Making Authority, Team Efficiency and Human Worker Satisfaction in Mixed Human-Robot Teams  

E-Print Network [OSTI]

Decision-Making Authority, Team Efficiency and Human Worker Satisfaction in Mixed Human-Robot Teams@csail.mit.edu Abstract-- In manufacturing, advanced robotic technology has opened up the possibility of integrating highly autonomous mobile robots into human teams. However, with this capability comes the issue of how

Reif, Rafael

491

College of Health and Human Sciences College of Health and Human  

E-Print Network [OSTI]

Sciences Office in L.L. Gibbons Building, Room 217 (970) 491-6331 www.chhs.colostate.edu Professor Jeff McCollege of Health and Human Sciences _______________ 2.8 Page 1 College of Health and Human Management Family and Consumer Sciences Fermentation Science and Technology Health and Exercise Science Human

492

The human genome project has revealed the DNA sequence that governs all biological processes in humans  

E-Print Network [OSTI]

The human genome project has revealed the DNA sequence that governs all biological processes step in the process of characterizing the human genome is the identification of genes. This prob- lem IN THE HUMAN GENOME We have been mapping transcribed regions using genomic tiling arrays. Tiling arrays enable

Gerstein, Mark

493

The Human Microbiome Project: A Community Resource for the Healthy Human Microbiome  

E-Print Network [OSTI]

The Human Microbiome Project (HMP) [1],[2] is a concept that was long in the making. After the Human Genome Project, interest grew in sequencing the “other genome" of microbes carried in and on the human body [3],[4]. ...

Gevers, Dirk

494

Computational Approaches Towards Human Genome Annotation  

E-Print Network [OSTI]

Computational Approaches Towards Human Genome Annotation Mark Gerstein Molecular Biophysics of the human genome. My talk will be concerned with topics within this area, in particular annotating pseudogenes (protein fossils) in the genome. I will discuss a comprehensive pseudogene identification pipeline

Singh, Jaswinder Pal

495

Substrate Balances across Colonic Carcinomas in Humans  

Science Journals Connector (OSTI)

...in humans, the balances of energy-yielding substrates and amino...observed. It is concluded that the energy metabolism of human colonic...1926. 6. Warburg, O., Wind, F., and Negelein, E. oeberden...glutamine, not sugar, is the major energy source for cultured HeLa cells...

Eggert Holm; Egbert Hagmüller; Ulrich Staedt; Gerwin Schlickeiser; Hans-Joachim Günther; Hans Leweling; Mehmet Tokus; and Hermann B. Kollmar

1995-03-15T23:59:59.000Z

496

Human Resource Management: Employee Compensation Guide  

E-Print Network [OSTI]

Human Resource Management: Employee Compensation Guide Risk Management *Extension Agricultural Economist, Kansas State University Agricultural Experiment Station and Cooperative Extension Service; and Extension Program Specialist III.... ?Employee Compensation and Job Satisfaction on Dairy Farms in the Northeast.? April 1999. Cornell University, RB99-02. Kansas Department of Human Resources. Kansas Wage Survey, 1996 Edition. Rosenberg, Howard. ?Labor Management Decisions.? University...

Fogleman, Sarah L.; McCorkle, Dean

2009-04-08T23:59:59.000Z

497

West Virginia University Division of Human Resources  

E-Print Network [OSTI]

on the WVU Division of Human Resources Web page hr.wvu.edu. In the event of a conflict between the current posted version and this printed copy, the posted version on the Web page is controlling. Page 1 of 2 of this administrative procedure has been posted on the WVU Division of Human Resources Web page hr.wvu.edu. In the event

Mohaghegh, Shahab

498

West Virginia University Division of Human Resources  

E-Print Network [OSTI]

Division of Human Resources Web page hr.wvu.edu. In the event of a conflict between the current posted version and this printed copy, the posted version on the Web page is controlling. Page 1 of 2 Access been posted on the WVU Division of Human Resources Web page hr.wvu.edu. In the event of a conflict

Mohaghegh, Shahab

499

West Virginia University Division of Human Resources  

E-Print Network [OSTI]

Division of Human Resources Web page hr.wvu.edu. In the event of a conflict between the current posted version and this printed copy, the posted version on the Web page is controlling. Page 1 of 2 Employment been posted on the WVU Division of Human Resources Web page hr.wvu.edu. In the event of a conflict

Mohaghegh, Shahab

500

West Virginia University Division of Human Resources  

E-Print Network [OSTI]

on the WVU Division of Human Resources Web page hr.wvu.edu. In the event of a conflict between the current posted version and this printed copy, the posted version on the Web page is controlling. Page 1 of 2 been posted on the WVU Division of Human Resources Web page hr.wvu.edu. In the event of a conflict

Mohaghegh, Shahab