Sample records for hospital chronic disease

  1. Interim Chronic Beryllium Disease

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-12-08T23:59:59.000Z

    Establishes Departmental expectations for addressing chronic beryllium disease throughout the Department until a Departmental rule on beryllium is promulgated. This Notice was replaced by final rule 10 CFR Part 850, Chronic Beryllium Disease Prevention Program, published December 8, 1999.

  2. Chronic Conditions and Disease Prevention

    E-Print Network [OSTI]

    , diabetes, heart disease and osteoarthritis. One-on-One Nutrition Counseling Help with weight management and supportive program for those who have chronic diseases such as diabetes, heart disease, stroke, arthritis

  3. Transgenic Mouse Model of Chronic Beryllium Disease

    SciTech Connect (OSTI)

    Gordon, Terry

    2009-05-26T23:59:59.000Z

    Animal models provide powerful tools for dissecting dose-response relationships and pathogenic mechanisms and for testing new treatment paradigms. Mechanistic research on beryllium exposure-disease relationships is severely limited by a general inability to develop a sufficient chronic beryllium disease animal model. Discovery of the Human Leukocyte Antigen (HLA) - DPB1Glu69 genetic susceptibility component of chronic beryllium disease permitted the addition of this human beryllium antigen presentation molecule to an animal genome which may permit development of a better animal model for chronic beryllium disease. Using FVB/N inbred mice, Drs. Rubin and Zhu, successfully produced three strains of HLA-DPB1 Glu 69 transgenic mice. Each mouse strain contains a haplotype of the HLA-DPB1 Glu 69 gene that confers a different magnitude of odds ratio (OR) of risk for chronic beryllium disease: HLA-DPB1*0401 (OR = 0.2), HLA-DPB1*0201 (OR = 15), HLA-DPB1*1701 (OR = 240). In addition, Drs. Rubin and Zhu developed transgenic mice with the human CD4 gene to permit better transmission of signals between T cells and antigen presenting cells. This project has maintained the colonies of these transgenic mice and tested the functionality of the human transgenes.

  4. Chronic beryllium disease: Diagnosis and management

    SciTech Connect (OSTI)

    Rossman, M.D. [Hospital of the Univ. of Pennsylvania, Philadelphia, PA (United States)

    1996-10-01T23:59:59.000Z

    Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis. While traditionally the pathologic changes included granulomas and cellular interstitial changes, the hallmark of the disease today is the well-formed granuloma. Immunologic studies have demonstrated a cell-mediated response to beryllium that is due to an accumulation of CD4{sup +} T cells at the site of disease activity. Diagnosis depends on the demonstration of pathologic changes (i.e., granuloma) and evidence that the granuloma was caused by a hypersensitivity to beryllium (i.e., positive lung proliferative response to beryllium). Using these criteria, the diagnosis of chronic beryllium disease can now be made before the onset of clinical symptoms. Whether, with early diagnosis, the natural course of this condition will be the same as when it was traditionally diagnosed is not known. Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease. 21 refs.

  5. Chronic Beryllium Disease Prevention Program Report

    SciTech Connect (OSTI)

    Lee, S

    2012-03-29T23:59:59.000Z

    This document describes how Lawrence Livermore National Laboratory (LLNL) meets the requirements and management practices of federal regulation 10 CFR 850, 'Chronic Beryllium Disease Prevention Program (CBDPP).' This revision of the LLNL CBDPP incorporates clarification and editorial changes based on lessons learned from employee discussions, observations and reviews of Department of Energy (DOE) Complex and commercial industry beryllium (Be) safety programs. The information is used to strengthen beryllium safety practices at LLNL, particularly in the areas of: (1) Management of small parts and components; and (2) Communication of program status to employees. Future changes to LLNL beryllium activities and on-going operating experience will be incorporated into the program as described in Section S, 'Performance Feedback.'

  6. Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives

    SciTech Connect (OSTI)

    Mostafalou, Sara; Abdollahi, Mohammad, E-mail: Mohammad.Abdollahi@UToronto.Ca

    2013-04-15T23:59:59.000Z

    Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders. There is also circumstantial evidence on the association of exposure to pesticides with some other chronic diseases like respiratory problems, particularly asthma and chronic obstructive pulmonary disease (COPD), cardiovascular disease such as atherosclerosis and coronary artery disease, chronic nephropathies, autoimmune diseases like systemic lupus erythematous and rheumatoid arthritis, chronic fatigue syndrome, and aging. The common feature of chronic disorders is a disturbance in cellular homeostasis, which can be induced via pesticides' primary action like perturbation of ion channels, enzymes, receptors, etc., or can as well be mediated via pathways other than the main mechanism. In this review, we present the highlighted evidence on the association of pesticide's exposure with the incidence of chronic diseases and introduce genetic damages, epigenetic modifications, endocrine disruption, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress and unfolded protein response (UPR), impairment of ubiquitin proteasome system, and defective autophagy as the effective mechanisms of action. - Highlights: ? There is a link between exposure to pesticides and incidence of chronic diseases. ? Genotoxicity and proteotoxicity are two main involved mechanisms. ? Epigenetic knowledge may help diagnose the relationships. ? Efficient policies on safe use of pesticides should be set up.

  7. Chronic Beryllium Disease Prevention Program (10 CFR 850) | Department of

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011AT&T, Inc.'sEnergyTexas1. Feedstock &Energy Chronic Beryllium Disease

  8. Feasibility and Acute Care Utilization Outcomes of a Post-Acute Transitional Telemonitoring Program for Underserved Chronic Disease Patients

    E-Print Network [OSTI]

    Bender, M; Davis, C; Smith, T; Broad, J

    2015-01-01T23:59:59.000Z

    A. A meta-analysis of remote monitoring of heart failureanalysis of remote patient monitoring for chronic heart failureanalysis showed telemonitoring reduces death and hospitalizations for heart failure (

  9. The Factors of Chronic Kidney Disease: Diabetes, Hypertension, Smoking, Drinking, Betelnut Chewing

    E-Print Network [OSTI]

    Chen, Chaur-Chin

    The Factors of Chronic Kidney Disease: Diabetes, Hypertension, Smoking, Drinking, Betelnut Chewing CKD 75 CKD Abstract The risk factors of Chronic Kidney Disease (CKD), including diabetes risk factors in a population-based cohort. Compared with single risk factors, diabetes (odds ratio 1

  10. Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk

    E-Print Network [OSTI]

    Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA 2 Case Western Reserve Accepted 1 August 2006 Chronic wasting disease (CWD) of elk (Cervus elaphus nelsoni) and mule deer

  11. Development of Biomarkers for Chronic Beryllium Disease in Mice

    SciTech Connect (OSTI)

    Gordon, Terry

    2013-01-25T23:59:59.000Z

    Beryllium is a strategic metal, indispensable for national defense programs in aerospace, telecommunications, electronics, and weaponry. Exposure to beryllium is an extensively documented occupational hazard that causes irreversible, debilitating granulomatous lung disease in as much as 3 - 5% of exposed workers. Mechanistic research on beryllium exposure-disease relationships has been severely limited by a general lack of a sufficient CBD animal model. We have now developed and tested an animal model which can be used for dissecting dose-response relationships and pathogenic mechanisms and for testing new diagnostic and treatment paradigms. We have created 3 strains of transgenic mice in which the human antigen-presenting moiety, HLA-DP, was inserted into the mouse genome. Each mouse strain contains HLA-DPB1 alleles that confer different magnitude of risk for chronic beryllium disease (CBD): HLA-DPB1*0401 (odds ratio = 0.2), HLA-DPB1*0201 (odds ratio = 15), HLA-DPB1*1701 (odds ratio = 240). Our preliminary work has demonstrated that the *1701 allele, as predicted by human studies, results in the greatest degree of sensitization in a mouse ear swelling test. We have also completed dose-response experiments examining beryllium-induced lung granulomas and identified susceptible and resistant inbred strains of mice (without the human transgenes) as well as quantitative trait loci that may contain gene(s) that modify the immune response to beryllium. In this grant application, we propose to use the transgenic and Â?normal inbred strains of mice to identify biomarkers for the progression of beryllium sensitization and CBD. To achieve this goal, we propose to compare the sensitivity and accuracy of the lymphocyte proliferation test (blood and bronchoalveolar lavage fluid) with the ELISPOT test in the three HLA-DP transgenic mice strains throughout a 6 month treatment with beryllium particles. Because of the availability of high-throughput proteomics, we will also identify changes in potential protein biomarkers in beryllium-treated mice. We will correlate these findings with the ability of the transgenic mice to develop a beryllium-specific adaptive immune response in blood and bronchoalveolar lavage (BAL) fluid. We will also determine whether beryllium-responsive CD4+ T cells in blood and BAL correlate with the onset of granuloma formation. Thus, we will provide the scientific community with biomarkers of sensitization and disease progression for CBD. These biomarkers will serve as critical tools for development of improved industrial hygiene and therapeutic interventions.

  12. Effect of chronic inhalation of inorganic arsenic on the risk of stillbirth in a community surrounding an agriculture chemical production facility: a hospital-based study 

    E-Print Network [OSTI]

    Ihrig, Melanie M

    1997-01-01T23:59:59.000Z

    EFFECT OF CHRONIC INHALATION OF INORGANIC ARSENIC ON THE RISK OF STILLBIRTH IN A COMMUNITY SURROUNDING AN AGRICULTURE CHEMICAL PRODUCTION FACILITY: A HOSPITAL-BASED STUDY A Thesis by MELANIE M. IHRIG Submitted to the Office of Graduate...

  13. Naam: mw. prof. dr. ir. Y.T. van der Schouw Leeropdracht Chronic Disease Epidemiology

    E-Print Network [OSTI]

    Utrecht, Universiteit

    differ between men and women, and how menopause and estrogens might be involved in this risk difference against chronic diseases of aging, such as cardiovascular disease, breast cancer, osteoporosis diabetics have been submitted. The third and most important area is the role of menopause and estrogens

  14. Asthma is a chronic inflammatory disease of the lungs that is increasingly observed in developed countries

    E-Print Network [OSTI]

    Cai, Long

    Asthma is a chronic inflammatory disease of the lungs that is increasingly observed in developed in the lungs. However, characteristic to both forms of the disease is the airway- wall accumulation of T helper are expressed either by skin8 or lung epithelial cells and can influence the way in which epithelial cells

  15. Costs of chronic disease and an alternative to reduce these costs: case study of End Stage Renal Disease (ESRD)

    E-Print Network [OSTI]

    Jang, Won-Ik

    2005-02-17T23:59:59.000Z

    COSTS OF CHRONIC DISEASE AND AN ALTERNATIVE TO REDUCE THESE COSTS: CASE STUDY OF END STAGE RENAL DISEASE (ESRD) A Dissertation by WON-IK JANG Submitted to the Office of Graduate Studies of Texas A&M University in partial...) A Dissertation by WON-IK JANG Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Approved as to style and content by...

  16. Relation of aortic valve calcium to chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  17. Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  18. Chronic Kidney Disease and Hypertension: The Paradox of Treating Patients with Spironolactone

    E-Print Network [OSTI]

    Pillow, Jonathan

    Chronic Kidney Disease and Hypertension: The Paradox of Treating Patients with Spironolactone Amber the correlation between CKD and hypertension 2. Describe the role of aldosterone in the renin-angiotensin-aldosterone system (RAAS) and in resistant hypertension 3. Explain the mechanism of aldosterone antagonists 4

  19. CS233917-AF National Center for Chronic Disease Prevention and Health Promotion

    E-Print Network [OSTI]

    CS233917-AF National Center for Chronic Disease Prevention and Health Promotion Division, Physical Activity, and Obesity Profile Obesity has important consequences on our nation's health by unhealthy options when it comes to diet and physical activity.We need public health approaches that make

  20. Cancer Reporting Rule R384-100 R384. Health, Community Health Services, Chronic Disease.

    E-Print Network [OSTI]

    Tipple, Brett

    Cancer Reporting Rule R384-100 R384. Health, Community Health Services, Chronic Disease. R384-100. Cancer Reporting Rule R384-100-1. Purpose Statement (1) The Cancer Reporting Rule is adopted under authority of sections 26-1-30 and 26-5-3. (2) Cancers Constitute a leading cause of morbidity and mortality

  1. Modeling Red Blood Cell and Iron Dynamics in Patients with Chronic Kidney Disease

    E-Print Network [OSTI]

    Modeling Red Blood Cell and Iron Dynamics in Patients with Chronic Kidney Disease H. T. Banks1, that stimulates red blood cell (RBC) production. Without intervention, patients suffer from anemia. Patients treatment. Keywords: mathematical model, mathematical biology, erythropoiesis, erythrocyte, red blood cell

  2. Implementation Guide for use with 10 CFR Part 850, Chronic Beryllium Disease Prevention Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2001-01-04T23:59:59.000Z

    The Department of Energy (DOE) has established regulatory requirements for the Chronic Beryllium Disease Prevention Program (CBDPP) in Title 10 of the Code of Federal Regulations (CFR), Part 850 (10 CFR 850) [64 Federal Register (FR) 68854]. Cancels DOE G 440.1-7. Certified 9-23-10.

  3. Comparing Online Community Structure of Patients of Chronic Diseases

    E-Print Network [OSTI]

    Maddali, Hanuma Teja; Margolis, Peter

    2015-01-01T23:59:59.000Z

    In this paper we compare the social network structure of people talking about Crohn's disease, Cystic Fibrosis, and Type 1 diabetes on Facebook and Twitter. We find that the Crohn's community's contributors are most emotional on Facebook and Twitter and most negative on Twitter, while the T1D community's communication network structure is most cohesive.

  4. Prevalence of chronic obstructive pulmonary disease in rural women of

    E-Print Network [OSTI]

    Silver, Whendee

    for refining disease burden assessments attributable to household biomass combustion Priscilla Johnson1 January and May 2007. COPD assessments were done using a combination of clinical examination spend !2 hours/day in the kitchen involved in cooking. Use of solid fuel was associated with higher risk

  5. Low Prevalence of Chronic Beryllium Disease among Workers at a Nuclear Weapons Research and Development Facility

    SciTech Connect (OSTI)

    Arjomandi, M; Seward, J P; Gotway, M B; Nishimura, S; Fulton, G P; Thundiyil, J; King, T E; Harber, P; Balmes, J R

    2010-01-11T23:59:59.000Z

    To study the prevalence of beryllium sensitization (BeS) and chronic beryllium disease (CBD) in a cohort of workers from a nuclear weapons research and development facility. We evaluated 50 workers with BeS with medical and occupational histories, physical examination, chest imaging with HRCT (N=49), and pulmonary function testing. Forty of these workers also underwent bronchoscopy for bronchoalveolar lavage (BAL) and transbronchial biopsies. The mean duration of employment at the facility was 18 yrs and the mean latency (from first possible exposure) to time of evaluation was 32 yrs. Five of the workers had CBD at the time of evaluation (based on histology or HRCT); three others had evidence of probable CBD. These workers with BeS, characterized by a long duration of potential Be exposure and a long latency, had a low prevalence of CBD.

  6. Memorandum, Clarification of Title 10 of the Code of Federal Regulations, Part 850 (10 CPR 850), Chronic Beryllium Disease Prevention Program, Paragraph 850.34(g)

    Broader source: Energy.gov [DOE]

    The purpose of this memorandum is to clarification regarding the reporting of beryllium sensitization (BeS) and chronic beryllium disease (CBD) as required by paragraph 850.34(g) of the Chronic Beryllium Disease Prevention Program rule (10 CFR 850).

  7. Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease

    E-Print Network [OSTI]

    Chang, Ruey-Kang R.; Chen, Alex Y.

    2010-01-01T23:59:59.000Z

    in infants with congenital heart disease. Pediatrics 114:children with congenital heart disease. The Cardiac StudySigni?cant Congenital Heart Disease Ruey-Kang R. Chang •

  8. Chronic graft-versus-host disease in the rat radiation chimera. III. Immunology and immunopathology in rapidly induced models

    SciTech Connect (OSTI)

    Beschorner, W.E.; Tutschka, P.J.; Santos, G.W.

    1983-03-01T23:59:59.000Z

    Although chronic graft-versus-host disease (GVHD) frequently develops in the long-term rat radiation chimera, we present three additional models in which a histologically similar disease is rapidly induced. These include adoptive transfer of spleen and bone marrow from rats with spontaneous chronic GVHD into lethally irradiated rats of the primary host strain; sublethal irradiation of stable chimeras followed by a booster transplant; and transfer of spleen cells of chimeras recovering from acute GVHD into second-party (primary recipient strain) or third-party hosts. Some immunopathologic and immune abnormalities associated with spontaneous chronic GVHD were not observed in one or more of the induced models. Thus, IgM deposition in the skin, antinuclear antibodies, and vasculitis appear to be paraphenomena. On the other hand, lymphoid hypocellularity of the thymic medulla, immaturity of splenic follicles, and nonspecific suppressor cells were consistently present in the long term chimeras, and in all models. These abnormalities therefore may be pathogenetically important, or closely related to the development of chronic GVHD.

  9. Efficacy of DVD Technology in Chronic Obstructive Pulmonary Disease Self- Management Education of Rural Patients

    E-Print Network [OSTI]

    Stellefson, Michael L.

    2010-01-14T23:59:59.000Z

    (chronic bronchitis) and parenchyma destruction (emphysema), the relative contributions of which differ from person to person (Buist et al., 2007). This causes an obstruction of air leaving the lungs, and consequently, prolonged episodes of coughing..., 2001). Exacerbations are defined as events in COPD characterized by change in patients? baseline dyspnea, cough, chest tightness and/or sputum that is beyond normal day-to-day variations and acute in onset (Burge & Wedzicha, 2003). Lung infections...

  10. A Perspective on the Maillard Reaction and the Analysis of Protein Glycation by Mass Spectrometry: Probing the Pathogenesis of Chronic Disease

    SciTech Connect (OSTI)

    Zhang, Qibin; Ames, Jennifer M.; Smith, Richard D.; Baynes, John; Metz, Thomas O.

    2008-12-18T23:59:59.000Z

    The Maillard reaction, starting from the glycation of protein and progressing to the formation of advanced glycation end-products (AGEs), is implicated in the development of complications of diabetes mellitus, as well as in the pathogenesis of cardiovascular, renal, and neurodegenerative diseases. In this perspective review, we provide on overview on the relevance of the Maillard reaction in the pathogenesis of chronic disease and discuss traditional approaches and recent developments in the analysis of glycated proteins by mass spectrometry. We propose that proteomics approaches, particularly bottom-up proteomics, will play a significant role in analyses of clinical samples leading to the identification of new markers of disease development and progression.

  11. Effect of chronic inhalation of inorganic arsenic on the risk of stillbirth in a community surrounding an agriculture chemical production facility: a hospital-based study

    E-Print Network [OSTI]

    Ihrig, Melanie M

    1997-01-01T23:59:59.000Z

    was exposed to levels of airborne arsenic not typically found in the environment in the United States, and in excess of Texas state Effect Screening Level (ESL). A hospital-based, case-control study of stillbirths was conducted at a major delivery hospital...

  12. Chronic graft-versus-host disease in the rat radiation chimera: I. clinical features, hematology, histology, and immunopathology in long-term chimeras

    SciTech Connect (OSTI)

    Beschorner, W.E.; Tutschka, P.J.; Santos, G.W.

    1982-04-01T23:59:59.000Z

    The clinical features, pathology, and immunopathology of chronic graft-versus-host disease (GVHD) developing in the long-term rat radiation chimera are described. At 6 to 12 months post-transplant, the previously stable ACI/LEW chimeras developed patchy to diffuse severe hair loss and thickened skin folds, and had microscopic features resembling scleroderma, Sjogren's syndrome, and chronic hepatitis. Skin histology showed dermal inflammation and acanthosis with atrophy of the appendages, with progression to dermal sclerosis. The liver revealed chronic hepatitis with bile duct injury and proliferation and periportal piecemeal necrosis. The tongue had considerable submucosal inflammation, muscular necrosis, and atrophy and arteritis. The serous salivary glands, lacrimal glands, and bronchi had lymphocytic inflammation and injury to duct, acinar, and mucosal columnar epithelium. The thymus had lymphocyte depletion of the medulla with prominent epithelium. The spleen and lymph nodes had poorly developed germinal centers but increased numbers of plasma cells. IgM was observed along the basement membrane and around the basal cells of the skin and tongue and along the basement membrane of the bile ducts. IgM was present also in the arteries of the tongue. Immunoglobulins eluted from the skin, cross-reacted with the bile duct epithelium and usually with both ACI and Lewis skin. Increased titers of speckled antinuclear antibodies were present in the serum of rats with chronic (GVHD). Chronic GVHD in the long-term rat radiation chimera is very similar to human chronic GVHD and is a potentially excellent model for autoimmune disorders including scleroderma, Sjorgren's syndrome, and chronic hepatitis.

  13. Examining Public Health System Responses to the Chronic Diseases of HIV/AIDS and Diabetes: Experiences from Mexico and Brazil

    E-Print Network [OSTI]

    Gidi, Virginia Eve

    2010-01-01T23:59:59.000Z

    www.improvingchroniccare.org/index.php? p=CCM_Gallery&s=149.and health system frameworks Chronic Care Models CCM ICCCFExpanded CCM Health System Models Roemer WHO Health Health

  14. Hospitality Management Hospitality Management

    E-Print Network [OSTI]

    McConnell, Terry

    of the Department of Hospitality Management and to the recorder in the College of Human Ecology. Required HPM 114 Food Safety and Quality Assurance 2 AND HPM 115 Food Science I 3 AND HPM 216 Restaurant and Food Service Operations 4 OR NSD 225 Nutrition in Health 3 12 credits needed: HPM 300 Selected Topics: Advanced

  15. The effects of maintenance schedules following pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomised controlled trial

    E-Print Network [OSTI]

    Wilson, Andrew M.; Browne, Paula; Olive, Sandra; Clark, Allan; Galey, Penny; Dix, Emma; Woodhouse, Helene; Robinson, Sue; Wilson, Edward C. F.; Staunton, Lindi

    2015-03-11T23:59:59.000Z

    as cough, anti- biotic use or purulent sputum within 4 weeks prior to randomisation), severe or uncontrolled comorbid disease, or abnormalities in cognitive functioning that would limit the patient’s ability to undertake the inter- vention. To enter...

  16. age chronic non-communicable: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease. Early symptoms of COPD include excessive sputum production and chronic cough. The primary (more) Toljamo, Tuula 2012-01-01 9 Parkinson disease (PD) is a chronic,...

  17. Hospital Renovations

    Broader source: Energy.gov [DOE]

    Hospitals have a range of energy needs that vary from a typical building, and a number of renewable energy options may make more sense for a hospital, including process and biomass heating, photovoltaics (PV), and sustainability.

  18. Sex-specific differences in hyperoxic lung injury in mice: Implications for acute and chronic lung disease in humans

    SciTech Connect (OSTI)

    Lingappan, Krithika, E-mail: lingappa@bcm.edu [Department of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine, 1102 Bates Avenue, MC: FC530.01, Houston, TX 77030 (United States); Jiang, Weiwu; Wang, Lihua; Couroucli, Xanthi I. [Department of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine, 1102 Bates Avenue, MC: FC530.01, Houston, TX 77030 (United States); Barrios, Roberto [Department of Pathology and Genomic Medicine, The Methodist Hospital Physician Organization, 6565 Fannin Street, Suite M227, Houston, TX 77030 (United States); Moorthy, Bhagavatula [Department of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine, 1102 Bates Avenue, MC: FC530.01, Houston, TX 77030 (United States)

    2013-10-15T23:59:59.000Z

    Sex-specific differences in pulmonary morbidity in humans are well documented. Hyperoxia contributes to lung injury in experimental animals and humans. The mechanisms responsible for sex differences in the susceptibility towards hyperoxic lung injury remain largely unknown. In this investigation, we tested the hypothesis that mice will display sex-specific differences in hyperoxic lung injury. Eight week-old male and female mice (C57BL/6J) were exposed to 72 h of hyperoxia (FiO{sub 2} > 0.95). After exposure to hyperoxia, lung injury, levels of 8-iso-prostaglandin F{sub 2} alpha (8-iso-PGF 2?) (LC–MS/MS), apoptosis (TUNEL) and inflammatory markers (suspension bead array) were determined. Cytochrome P450 (CYP)1A expression in the lung was assessed using immunohistochemistry and western blotting. After exposure to hyperoxia, males showed greater lung injury, neutrophil infiltration and apoptosis, compared to air-breathing controls than females. Pulmonary 8-iso-PGF 2? levels were higher in males than females after hyperoxia exposure. Sexually dimorphic increases in levels of IL-6 (F > M) and VEGF (M > F) in the lungs were also observed. CYP1A1 expression in the lung was higher in female mice compared to males under hyperoxic conditions. Overall, our results support the hypothesis that male mice are more susceptible than females to hyperoxic lung injury and that differences in inflammatory and oxidative stress markers contribute to these sex-specific dimorphic effects. In conclusion, this paper describes the establishment of an animal model that shows sex differences in hyperoxic lung injury in a temporal manner and thus has important implications for lung diseases mediated by hyperoxia in humans. - Highlights: • Male mice were more susceptible to hyperoxic lung injury than females. • Sex differences in inflammatory markers were observed. • CYP1A expression was higher in females after hyperoxia exposure.

  19. Enterprise Assessments Follow-up Review of the Hanford Site Chronic...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Assessments Follow-up Review of the Hanford Site Chronic Beryllium Disease Prevention Program - June 2015 Enterprise Assessments Follow-up Review of the Hanford Site Chronic...

  20. Reconfiguring Care for Chronic Disease with Home Monitoring: A Pilot Study Report on Telemetry-Supported Care for COPD Patients in the Lothian Region 

    E-Print Network [OSTI]

    Ure, Jenny; Kydd, Gillian; Tarling, Alex; McKinstry, Brian; Hanley, Janet; Pagliari, Claudia; Pinnock, Hilary; Sheikh, Aziz; MacNee, William; McCall Smith, Emily; Corscadden, Paddy

    2009-01-01T23:59:59.000Z

    A qualitative report of users' experiences of home telemonitoring in COPD (Chronic Obstructive Lung Disorder) in Lothian Region. This research, with patients, carers, nurses, physiotherapists and GPs provided an early ...

  1. Kidney Disease of Diabetes

    E-Print Network [OSTI]

    Baker, Chris I.

    Kidney Disease of Diabetes National Kidney and Urologic Diseases Information Clearinghouse is the final stage of chronic kidney disease (CKD). Diabetes is the most common cause of kidney failure, accounting for nearly 44 percent of new cases.1 Even when diabetes is controlled, the disease can lead to CKD

  2. Sex-dependent effects of chronic restraint stress during early Theiler's virus infection on the subsequent demyelinating disease in CBA mice

    E-Print Network [OSTI]

    Meagher, Mary

    ,b , Ralph Storts c , Thomas H. Welsh b,d , C. Jane R. Welsh b,c , Mary W. Meagher a,* a Department 350,000 people in the United States alone (Anderson et al., 1992). Though the etiology of MS remains of the disease (Ackerman et al., 2003; Anderson et al., 1992; Mohr and Cox, 2001; Mohr et al., 2004; Noseworthy

  3. MAPUniversity Hospital Directions from University Hospital to

    E-Print Network [OSTI]

    Pharmacy Lobby Visitor Elevators Escalator Patient Elevators University Hospital Information Elevator G MRI/Nuclear Medicine H Thrombosis Center I Interventional Radiology J Rehab Specialty Clinics K

  4. Characterization of Lung's Emphysema Distribution: Numerical Assessment of Disease Development

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Characterization of Lung's Emphysema Distribution: Numerical Assessment of Disease Development M, Egypt. Abstract--Chronic Obstructive Pulmonary Disease (COPD) refers to a group of lung diseases bronchitis. Pulmonary emphysema is defined as a lung disease characterized by "abnormal enlargement

  5. IAQ in Hospitals - Better Health through Indoor Air Quality Awareness

    E-Print Network [OSTI]

    Al-Rajhi, S.; Ramaswamy, M.; Al-Jahwari, F.

    2010-01-01T23:59:59.000Z

    .S, 2004). Nordstrom and his team from Sweden investigated IAQ in hospitals in relation to building dampness and type of construction. They analyzed four hospital buildings of different age and design and concluded that building dampness in the floor...? Department of Occupational and Environmental Medicine, Uppsala University hospital, Sweden.1998 Proc CIB World Building Congress ,Gaevle,Sweden. ? O'Neal C. Infection control; Keeping diseases at bay a full-time effort for healthcare professionals...

  6. Accidental Hospital Deaths

    E-Print Network [OSTI]

    Bhat, Prashant

    2011-01-01T23:59:59.000Z

    Staphylococcus Aureus (MRSA) Bloodstream Infections. Scienceof Antibiotic-Resistant MRSA Bacteria. Consumersunion.org.Staphylococcus Aureus (MRSA), the leading cause of hospital

  7. Cadmium, diabetes and chronic kidney disease

    SciTech Connect (OSTI)

    Edwards, Joshua R. [Department of Pharmacology, Midwestern University, Downers Grove, IL 60515 (United States)], E-mail: jedwar@midwestern.edu; Prozialeck, Walter C. [Department of Pharmacology, Midwestern University, Downers Grove, IL 60515 (United States)

    2009-08-01T23:59:59.000Z

    Recent epidemiological studies suggest a positive association between exposure to the environmental pollutant cadmium (Cd) and the incidence and severity of diabetes. In this review, we examine the literature suggesting a relationship between Cd exposure, elevated blood glucose levels, and the development of diabetes. In addition we review human and animal studies indicating that Cd potentiates or exacerbates diabetic nephropathy. We also review the various possible cellular mechanisms by which Cd may alter blood glucose levels. In addition, we present some novel findings from our own laboratories showing that Cd elevates fasting blood glucose levels in an animal model of subchronic Cd exposure before overt signs of renal dysfunction are evident. These studies also show that Cd reduces insulin levels and has direct cytotoxic effects on the pancreas. Together, these findings indicate that Cd may be a factor in the development of some types of diabetes and they raise the possibility that Cd and diabetes-related hyperglycemia may act synergistically to damage the kidney.

  8. Chronic Beryllium Disease Prevention Program What's New

    Broader source: Energy.gov [DOE]

    For additional information Contact: David Weitzman, Office of Worker Safety and Health Policy at (301) 903-5401 or: David.Weitzman@hq.doe.gov.

  9. Drug Overdose Deaths, Hospitalizations,

    E-Print Network [OSTI]

    MacAdam, Keith

    Drug Overdose Deaths, Hospitalizations, and Emergency Department Visits in Kentucky, 2000 - 2012 #12; Kentucky Injury Preven on and Research Center Drug Overdose Deaths, Hospitaliza ons . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Drug overdose deaths, 20002012

  10. Rhodes Hall Ross Heart Hospital

    E-Print Network [OSTI]

    Howat, Ian M.

    Emergency 315 315 26 Rhodes Hall Ross Heart Hospital James Cancer Hospital Martha Morehouse.m. James Cancer Hospital 7:10 a.m. Rhodes Hall 7:13 a.m. Ross Heart Hospital 7:15 a.m. Martha Morehouse

  11. adult kawasakis disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    association. Renee D. Goodwin; Daniel S. Pine 24 MRI-based Three dimensional shape analysis of thigh muscles: people with Chronic Obstructive Pulmonary Disease versus healthy...

  12. HumanoidHospital Sustainable

    E-Print Network [OSTI]

    Beex, A. A. "Louis"

    HHO HumanoidHospital Nanoscale Science Nano-Bio Interface Sustainable Energy Renewable Materials Areas Vision IcHHo will address the problem of accidental medical errors by developing an intelligent real-life medical scenarios. Mission IcHHO will develop interactive Humanoid Patients (male, female

  13. HOSPITAL COVER INTERMEDIATE

    E-Print Network [OSTI]

    a lower premium. Plus, our unique Excess Bonus feature applies to Level 2. You can choose an excess option of: Level 1 No excess Level 2 $250 - plus our Excess Bonus feature applies Level 3 $500 Excess options Excess Bonus feature ­ available on Corporate Hospital Intermediate Level 2. It means you won

  14. Beryllium disease

    SciTech Connect (OSTI)

    Not Available

    1991-12-20T23:59:59.000Z

    After two workers at the nuclear weapons plant at Oak Ridge National Laboratory in Tennessee were diagnosed earlier this year with chronic beryllium disease (CBD), a rare and sometimes fatal scarring of the lungs, the Department of Energy ordered up a 4-year probe. Now, part of that probe has begun - tests conducted by the Oak Ridge Associated Universities' Center for Epidemiological Research measuring beryllium sensitivity in 3,000 people who've been exposed to the metal's dust since Manhattan Project managers opened the Y-12 plant at Oak Ridge in 1943. Currently, 119 Y-12 employees process beryllium, which has a number of industrial uses, including rocket heat shields and nuclear weapon and electrical components. The disease often takes 20 to 25 years to develop, and the stricken employees haven't worked with beryllium for years. There is no cure for CBD, estimated to strike 2% of people exposed to the metal. Anti-inflammatory steroids alleviate such symptoms as a dry cough, weight loss, and fatigue. Like other lung-fibrosis diseases that are linked to lung cancer, some people suspect CBD might cause some lung cancer. While difficult to diagnose, about 900 cases of CBD have been reported since a Beryllium Case Registry was established in 1952. The Department of Energy (DOE) estimates that about 10,000 DOE employees and 800,000 people in private industry have worked with beryllium.

  15. HOSPITAL ENERGY AUDITS: A BIBLIOGRAPHY

    E-Print Network [OSTI]

    Pollack, R. I.

    2011-01-01T23:59:59.000Z

    J.W. "Professional Energy Audit Points Way to $100,000Hosp-79-3 NIA HOSPITAL ENERGY AUDITS: A BIBLIOGRAPHY R. I.information. HOSPITAL ENERGY AUDIT REPORTS Anco Engineers

  16. Cough REVIEW Chronic cough hypersensitivity syndrome

    E-Print Network [OSTI]

    Alyn H Morice

    Chronic cough has been suggested to be due to three conditions, asthma, post nasal drip, and reflux disease. A different paradigm has evolved in which cough is viewed as the primary condition characterised by afferent neuronal hypersensitivity and different aspects of this syndrome are manifest in the different phenotypes of cough. There are several advantages to viewing cough hypersensitivity as the unifying diagnosis; Communication with patients is aided, aetiology is not restricted and therapeutic avenues opened. Cough Hypersensitivity Syndrome is a more applicable label to embrace the clinical manifestations of this disabling disease.

  17. auxiliares del hospital: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Geosciences Websites Summary: of University Hospital, University Hospital East, James Cancer Hospital and Solove Research Institute, Ross Heart Hospital, OSU Harding Hospital,...

  18. Understanding Hospital Admissions Close to the End of Life (ACE) Study

    E-Print Network [OSTI]

    Morris, Zoë S; Fyfe, Miranda; Momen, Natalie; Hoare, Sarah; Barclay, Stephen

    2013-03-11T23:59:59.000Z

    - istrative areas, with different demographic profiles rele- vant to place of death, including access to services. The first area is largely rural, with a university city and larger towns and areas of significant social deprivation and af- fluence. The second... Pulmonary Disease, or cancer who die within 72 hours of admission to of the two hospitals. Patients will be identified retrospectively with help from the hospitals’ Bereavement Services. These Ser- vices receive the hospital notes and organise the death cer...

  19. Non-invasive markers of inflammation in cystic fibrosis lung disease 

    E-Print Network [OSTI]

    MacGregor, Gordon

    2010-01-01T23:59:59.000Z

    Cystic fibrosis (CF) lung disease is characterised by early airways infection and inflammation, chronic suppuration, frequent infective exacerbations and an increased influx of acute, and chronic inflammatory cells. The ...

  20. Radiation Protection Guidance Hospital Staff

    E-Print Network [OSTI]

    Kay, Mark A.

    Page 1 Radiation Protection Guidance For Hospital Staff Prepared for Stanford ..................................................................................................................... 17 The Basic Principles of Radiation Protection........................................................... 17 Protection against Radiation Exposure

  1. Hospitals & Climate Change: Opportunity for Transformational Leadership?

    E-Print Network [OSTI]

    Howat, Ian M.

    Efficiency and Hospitals OHA Energy & Sustainability Program OSU Byrd Polar Research Institute May 15, 2014 2 Hospital Association Energy & Sustainability Program Since 2000, OHA has intervened on behalf of hospitals · "Gaps" shared among peers 12 DP&L Hospitals Served by OHA Energy & Sustainability Program 55 hospitals

  2. Good Samaritan Hospital`s energy efficiency improvements

    SciTech Connect (OSTI)

    Sterrett, R.; Dobberpuhl, W.; Gernet, B.; O`Brien, T.

    1995-06-01T23:59:59.000Z

    Arizona Public Service (APS) encourages its customers to use energy wisely by providing incentives to install energy efficient systems. APS provided an incentive to the Good Samaritan Hospital, located in Phoenix, Arizona, to install a Waste Heat Recovery Unit and an Economizer Cooling System to improve the performance of the hospital`s central plant. Waste heat recovered from the boilers stacks is used to preheat combustion air and boiler feed water. The Economizer Cooling System uses a plate and frame heat exchanger to cool the hospital with cold water produced by the cooling tower rather than an electrical chiller. To determine the effectiveness of these two systems APS initiated a project to monitor their performance. Alternative Energy Systems Consulting, Inc. (AESC) has installed instrumentation to monitor the performance of the above systems and will document their energy savings and effectiveness at reducing energy costs.

  3. Design of a numerical model for simulation of blood microcirculation and study of sickle cell disease

    E-Print Network [OSTI]

    Le Floch-Yin, François T. (François Thomas)

    2010-01-01T23:59:59.000Z

    Sickle cell disease is nowadays one of the most challenging blood diseases, where patients suffer from both chronic and acute episodes of painful medical conditions. In particular, unpredictable crises due to blood vessel ...

  4. arterial disease severity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with chronic Roche, Benjamin 62 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  5. artery disease severity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with chronic Roche, Benjamin 62 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...

  6. Hospital A Hospital B Hospital C Practice Variation in Emergency Department Management of Children

    E-Print Network [OSTI]

    or in the ED was included for analysis. · Patients taking antibiotics within 24 hours of the visit (pretreated Institute Training Grant T35 HL072483 (Harder). · Kris Gutierrez and Rob Thielke: Data retrieval from the Children's Hospital of Wisconsin clinical data warehouse. · Haydee Zimmerman: Access Database design

  7. Usability of Outdoor Spaces in Children's Hospitals 

    E-Print Network [OSTI]

    Pasha, Samira

    2012-07-16T23:59:59.000Z

    Researchers have studied the positive effect of healing outdoor environments on hospitalized children, their family members and staff's health and mood. Consequently many modern hospitals dedicate portions of their space ...

  8. Elec 331 -Hospital Safety Power Distribution

    E-Print Network [OSTI]

    Pulfrey, David L.

    - Hospital Safety 7 Ground Fault Interrupter Test Reset Gnd Ref Hot Ref Hot Test / Reset Relay Relay : 5 to 30 mA, Protection #12;Elec 331 - Hospital Safety 8

  9. Chronic Beryllium Disease Prevention Environment, Safety, Health, and Quality Division

    E-Print Network [OSTI]

    Wechsler, Risa H.

    , machining, and using beryllium and their supervisors; the Industrial Hygiene Group, Field Services Beryllium is an element with various industrial uses that is classified as a suspected human lung carcinogen of copper, which makes beryllium a useful material for aerospace and defense. It has various industrial uses

  10. Patient education for phosphorus management in chronic kidney disease

    E-Print Network [OSTI]

    Kalantar-Zadeh, Kamyar

    2013-01-01T23:59:59.000Z

    comparative trial versus calcium carbonate. Nephron Clinin predialysis patients on calcium carbonate or sevelamer.of sevelamer and calcium carbonate effects on cardiovascular

  11. Skeletal muscle mitochondrial depletion and dysfunction in chronic kidney disease

    E-Print Network [OSTI]

    Yazdi, Puya G; Moradi, Hamid; Yang, Jia-Ying; Wang, Ping H; Vaziri, Nasratola D

    2013-01-01T23:59:59.000Z

    primary source for energy production and generation of re-mass, depressed energy production and increased ROSIII- impaired energy production (mitochondrial dysfunction/

  12. EAT SMART -Chronic Disease Program MONTH TOPIC PROGRAM DETAILS

    E-Print Network [OSTI]

    SMART for Bone Health Discuss the risk factors associated with osteoporosis and the steps necessary on the risk factors for osteoporosis, and how to promote bone health by consuming foods rich in calcium

  13. ATTACHMENT 1: HANFORD SITE CHRONIC BERYLLIUM DISEASE PREVENTION...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for communication to the workforce Provide Program status to the Senior Management Team (SMT) and DOE management when requested 4.0 Roles and Responsibilities 4.1. Chair Roles and...

  14. Dynamic Adaptive Remote Health Monitoring for Patients with Chronic Disease

    E-Print Network [OSTI]

    Suh, Myung-kyung

    2012-01-01T23:59:59.000Z

    Jain. “Prediction models for a smart home based health carepressure data in the smart home-based health care system [

  15. Title 10 CFR Part 850, Chronic Beryllium Disease Prevention Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron Spin Transition in2, 2003 (NextTime-Resolved Study91 to6-000Name Office

  16. Original article Lentivirus-induced interstitial lung disease

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Lentivirus-induced interstitial lung disease: pulmonary pathology in sheep a chronic disease in sheep affecting, among other organs, the lungs. Interstitial pneumonitis is similar the pathological features of lungs of sheep naturally infected with visna-maedi virus with the results obtained

  17. Information Regarding MENINGOCOCCAL DISEASE

    E-Print Network [OSTI]

    . Meningococcal disease is a serious disease, caused by bacteria. Meningococcal disease is a contagious

  18. Percutaneous Endovascular Treatment of Chronic Iliac Artery Occlusion

    SciTech Connect (OSTI)

    Carnevale, F. C. [Institute of Radiology, University of Sao Paulo, Department of Interventional Radiology (Brazil)], E-mail: fcarnevale@uol.com.br; De Blas, Mariano; Merino, Santiago; Egana, Jose M. [Hospital De Guipuzcoa, Department of Radiology (Spain); Caldas, Jose G.M.P. [Institute of Radiology, University of Sao Paulo, Department of Interventional Radiology (Brazil)

    2004-09-15T23:59:59.000Z

    Purpose: To evaluate the clinical and radiological long-term results of recanalization of chronic occluded iliac arteries with balloon angioplasty and stent placement.Methods: Sixty-nine occluded iliac arteries (mean length 8.1 cm; range 4-16 cm) in 67 patients were treated by percutaneous transluminal angioplasty and stent placement. Evaluations included clinical assesment according to Fontaine stages, Doppler examinations with ankle-brachial index (ABI) and bilateral lower extremity arteriograms. Wallstent and Cragg vascular stents were inserted for iliac artery recanalization under local anesthesia. Follow-up lasted 1-83 months (mean 29.5 months).Results: Technical success rate was 97.1% (67 of 69). The mean ABI increased from 0.46 to 0.85 within 30 days after treatment and was 0.83 at the most recent follow-up. Mean hospitalization time was 2 days and major complications included arterial thrombosis (3%), arterial rupture (3%) and distal embolization (1%). During follow-up 6% stenosis and 9% thrombosis of the stents were observed. Clinical improvement occurred in 92% of patients. Primary and secondary patency rates were 75% and 95%, respectively.Conclusion: The long-term patency rates and clinical benefits suggest that percutaneous endovascular revascularization with metallic stents is a safe and effective treatment for patients with chronic iliac artery occlusion.

  19. Questions and Answers About LeukemiaCENTERS FOR DISEASE CONTROL AND PREVENTION

    E-Print Network [OSTI]

    the disease develops (acute vs. chronic leukemia) and by the type of blood cell involved (lymphocytic and myeloid leukemia being the most common). In acute leukemia, bone marrow cells are immature and are unable slowly. The most common types of leukemia are acute lymphocytic leukemia, acute myeloid leukemia, chronic

  20. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01T23:59:59.000Z

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's penumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  1. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01T23:59:59.000Z

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's pneumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  2. Modesto Memorial Hospital Space Heating Low Temperature Geothermal...

    Open Energy Info (EERE)

    Memorial Hospital Space Heating Low Temperature Geothermal Facility Jump to: navigation, search Name Modesto Memorial Hospital Space Heating Low Temperature Geothermal Facility...

  3. Fort Boise Veteran's Hospital District Heating Low Temperature...

    Open Energy Info (EERE)

    Veteran's Hospital District Heating Low Temperature Geothermal Facility Jump to: navigation, search Name Fort Boise Veteran's Hospital District Heating Low Temperature Geothermal...

  4. Warm Springs State Hospital Space Heating Low Temperature Geothermal...

    Open Energy Info (EERE)

    State Hospital Space Heating Low Temperature Geothermal Facility Jump to: navigation, search Name Warm Springs State Hospital Space Heating Low Temperature Geothermal Facility...

  5. Combined Heat and Power (CHP) Resource Guide for Hospital Applications...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Resource Guide for Hospital Applications, 2007 Combined Heat and Power (CHP) Resource Guide for Hospital Applications, 2007 The objective of this 2007 guidebook is to provide a...

  6. anos em hospital: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Postle Dental Clinics Davis Heart and Lung Research Institute Davis Medical Clinic James Cancer Hospital P ? ? ? ? ? ? Ross Heart Hospital Cramblett Medical Clinic Goobta MRI OSU...

  7. Alzheimer caregiving stress and atherosclerotic disease : psychosocial and physiological pathways linking chronic stress to disease

    E-Print Network [OSTI]

    Buehler, Susan Kyung; Buehler, Susan Kyung

    2012-01-01T23:59:59.000Z

    Medicine, 52(3-4), 208-212. O'Leary, D. H. , Polak, J. F. ,A. , Sidney, S. , & O'Leary, D. H. (2010). Segment-specificand myocardial infarction (O'Leary et al. , 1999). Moreover,

  8. Pulmonary arterial hypertension and cor pulmonale associated with chronic domestic woodsmoke inhalation

    SciTech Connect (OSTI)

    Sandoval, J.; Salas, J.; Martinez-Guerra, M.L.; Gomez, A.; Martinez, C.; Portales, A.; Palomar, A.; Villegas, M.; Barrios, R. (Instituto Nacional de Cardiologia, Ignacio Chavez, Mexico City (Mexico))

    1993-01-01T23:59:59.000Z

    We describe the clinical, radiologic, functional, and pulmonary hemodynamic characteristics of a group of 30 nonsmoking patients with a lung disease that may be related to intense, long-standing indoor wood-smoke exposure. The endoscopic and some of the pathologic findings are also presented. Intense and prolonged wood-smoke inhalation may produce a chronic pulmonary disease that is similar in many aspects to other forms of inorganic dust-exposure interstitial lung disease. It affects mostly country women in their 60s, and severe dyspnea and cough are the outstanding complaints. The chest roentgenograms show a diffuse, bilateral, reticulonodular pattern, combined with normalized or hyperinflated lungs, as well as indirect signs of pulmonary arterial hypertension (PAH). On the pulmonary function test the patients show a mixed restrictive-obstructive pattern with severe hypoxemia and variable degrees of hypercapnia. Endoscopic findings are those of acute and chronic bronchitis and intense anthracotic staining of the airways appears to be quite characteristic. Fibrous and inflammatory focal thickening of the alveolar septa as well as diffuse parenchymal anthracotic deposits are the most prominent pathologic findings, although inflammatory changes of the bronchial epithelium are also present. The patients had severe PAH in which, as in other chronic lung diseases, chronic alveolar hypoxia may play the main pathogenetic role. However, PAH in wood-smoke inhalation-associated lung disease (WSIALD) appears to be more severe than in other forms of interstitial lung disease and tobacco-related COPD. The patients we studied are a selected group and they may represent one end of the spectrum of the WSIALD.

  9. Jackson Park Hospital Green Building Medical Center

    SciTech Connect (OSTI)

    William Dorsey; Nelson Vasquez

    2010-03-01T23:59:59.000Z

    Jackson Park Hospital completed the construction of a new Medical Office Building on its campus this spring. The new building construction has adopted the City of Chicago�s recent focus on protecting the environment, and conserving energy and resources, with the introduction of green building codes. Located in a poor, inner city neighborhood on the South side of Chicago, Jackson Park Hospital has chosen green building strategies to help make the area a better place to live and work.

  10. Challenges and Opportunities in Academic Hospital Medicine: Report from the Academic Hospital Medicine Summit

    E-Print Network [OSTI]

    Flanders, Scott A.; Centor, Bob; Weber, Valerie; McGinn, Thomas; DeSalvo, Karen; Auerbach, Andrew

    2009-01-01T23:59:59.000Z

    Association of Professors of Medicine Brad Sharpe, M.D. ,Staff, Society of Hospital Medicine Amy Woodward, Supportof General Internal Medicine. Disclosures: Dr. Auerbach is a

  11. active chronic hepatitis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: ??abstractChronic hepatitis C virus infection (HCV) affects 180 million people worldwide. Chronic HCV can cause hepatic decompensation, hepatocellular carcinoma...

  12. advanced chronic hepatitis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: ??abstractChronic hepatitis C virus infection (HCV) affects 180 million people worldwide. Chronic HCV can cause hepatic decompensation, hepatocellular carcinoma...

  13. Occupational exposures and chronic respiratory symptoms. A population-based study

    SciTech Connect (OSTI)

    Korn, R.J.; Dockery, D.W.; Speizer, F.E.; Ware, J.H.; Ferris, B.G. Jr.

    1987-08-01T23:59:59.000Z

    Data from a random sample of 8515 white adults residing in 6 cities in the eastern and midwestern United States were used to examine the relationships between occupational exposures to dust or to gases and fumes and chronic respiratory symptoms; 31% of the population had a history of occupational dust exposure and 30% reported exposure to gas or fumes. After adjusting for smoking habits, age, gender, and city of residence, subjects with either occupational exposure had significantly elevated prevalences of chronic cough, chronic phlegm, persistent wheeze, and breathlessness. The adjusted relative odds of chronic respiratory symptoms for subjects exposed to dust ranged from 1.32 to 1.60. Subjects with gas or fume exposure had relative odds of symptoms between 1.27 and 1.43 when compared with unexposed subjects. Occupational dust exposure was associated with a higher prevalence of chronic obstructive pulmonary disease as defined by an FEV1/FVC ratio of less than 0.6, when comparing exposed and unexposed participants (OR = 1.53, 95% Cl = 1.17-2.08). Gas or fume exposure was associated with a small, but not significant, increase in COPD prevalence. Significant trends were noted for wheeze and phlegm with increasing duration of dust exposure. Although 36% of exposed subjects reported exposure to both dust and fumes, there was no evidence of a multiplicative interaction between the effects of the individual exposures. Smoking was a significant independent predictor of symptoms, but did not appear to modify the effect of dust or fumes on symptom reporting. These data, obtained in random samples of general populations, demonstrate that chronic respiratory symptoms and disease can be independently associated with occupational exposures.

  14. Occupational exposures and chronic respiratory symptoms: a population-based study

    SciTech Connect (OSTI)

    Korn, R.J.; Dockery, D.W.; Speizer, F.E.; Ware, J.H.; Ferris, B.G.

    1987-01-01T23:59:59.000Z

    Data from a random sample of 8515 white adults residing in six cities in the eastern and midwestern United States were used to examine the relationships between occupational exposures to dust or to gases and fumes and chronic respiratory symptoms. 31% of the population had a history of occupational dust exposure and 30% reported exposure to gas or to fumes. After adjusting for smoking habits, age, gender, and city of residence, subjects with either occupational exposure had significantly elevated prevalence of chronic cough, chronic phlegm, persistent wheeze, and breathlessness. The adjusted relative odds of chronic respiratory symptoms for subjects exposed to dust ranged from 1.32 to 1.60. Subjects with gas or fume exposure had relative odds of symptoms between 1.27 and 1.43 when compared to unexposed subjects. Occupational dust exposure was associated with a higher prevalence of chronic obstructive pulmonary disease (COPD) as defined by an FEV1/FVC ratio of less than 0.6, when comparing exposed and unexposed participants (OR=1.53, 95% CI=1.17-2.08). Gas or fume exposure was associated with a small, but not significant, increase in COPD prevalence. Significant trends were noted for wheeze and phlegm with increasing duration of dust exposure. Although 36% of exposed subjects reported exposure to both dust and fumes, there was no evidence of a multiplicative interaction between the effects of the individual exposures. Smoking was a significant independent predictor of symptoms, but did not appear to modify the effect of dust or fumes on symptom reporting. These data, obtained in random samples of general populations, demonstrate that chronic respiratory disease can be independently associated with occupational exposures.

  15. Disease-Specific Symptoms and Health-Related Quality of Life in Children and Adolescents with Inflammatory Bowel Disease

    E-Print Network [OSTI]

    Vaughan-Dark, Chelsea Ann

    2013-07-17T23:59:59.000Z

    , & Tennen, 2006). Therefore, HRQOL provides valuable information about patient outcomes in terms of successful adaptation to chronic illness (Livneh, 2001; Varni, Burwinkle, & Lane, 2005). Although HRQOL is a broad concept that may encompass a number...; Cortina, McGraw, deAlarcon, Rothenberg, & Drotar, 2010; Varni et al., 2006; Varni et al., 2007). Within the category of gastrointestinal disorders, Crohn?s disease and ulcerative colitis, two conditions subsumed under the overarching disease category...

  16. Invest in Your Bones Osteoporosis--The Silent Disease

    E-Print Network [OSTI]

    Invest in Your Bones Osteoporosis--The Silent Disease Leaflet 2 Osteoporosis, a painful of State Health Services, 2008). Osteoporosis is preventable and/or treatable. Accordingly, osteoporosis of height, and chronic back pain. Hip fracture, the most serious consequence of osteoporosis, threatens one

  17. Chronic respiratory effects of indoor formaldehyde exposure

    SciTech Connect (OSTI)

    Krzyzanowski, M.; Quackenboss, J.J.; Lebowitz, M.D.

    1990-01-01T23:59:59.000Z

    The relation of chronic respiratory symptoms and pulmonary function to formaldehyde (HCHO) in homes was studied in a sample of 298 children (6-15 years of age) and 613 adults. HCHO measurements were made with passive samplers two one-week periods. Data on chronic cough and phlegm, wheeze, attacks of breathlessness, and doctor diagnoses of chronic bronchitis and asthma were collected with self-completed questionnaires. Peak expiratory flow rates (PEFR) were obtained during the evenings and mornings for up to 14 consecutive days for each individual. Significantly greater prevalence rates of asthma and chronic bronchitis were found in children from houses with HCHO levels 60-120 ppb than in those less exposed, especially in children also exposed to environmental tobacco smoke. In children, levels of PEFR linearly decreased with HCHO exposure, with estimated decrease due to 60 ppb of HCHO equivalent to 22% of PEFR level in nonexposed children.

  18. Patterns of health and disease have undergone dramatic transitions during human history, reflecting social and

    E-Print Network [OSTI]

    Vermont, University of

    of infectious disease and infant mortality decreased, lengthening life expectancy.At the same time,noninfectious chronic disease rose, accounting for a greater share of over- all mortality. Greater water and air dispersed into new habitats by phoresy (i.e.,one organism transporting another), flight, or wind, but human

  19. Bullous Lung Disease

    E-Print Network [OSTI]

    Goldberg, Corey; Carey, Kathleen E

    2013-01-01T23:59:59.000Z

    thorascopic surgery. Bullous Lung Disease REFERENCES 1.S, Kaiser LR. Giant bullous lung disease: evaluation,for bullous disease of the lung. Eur J Cardiothorac Surg.

  20. FOOD SUSTAINABILITY REPORT QUEEN'S HOSPITALITY SERVICES

    E-Print Network [OSTI]

    Ellis, Randy

    FOOD SUSTAINABILITY REPORT QUEEN'S HOSPITALITY SERVICES May 2008 #12;In recent years, a sustainability movement has taken root at Queen's. The impacts of the movement can be seen across campus sustainability position within the their student government ­The AMS, The Engineer Society open the Tea Room

  1. VETERINARY TEACHING HOSPITAL 1602 Campus Delivery

    E-Print Network [OSTI]

    with 7 or more years' of experience or Associate of Applied Science degree with 7 years' of experience Sciences Position Summary: The Veterinary Teaching Hospital (VTH) at Colorado State University (CSU) seeks of integrity. Superior interpersonal communication and presentation skills as well as proven organizat

  2. FEATURE ARTICLE 2 Kunde Hospital: Nepal

    E-Print Network [OSTI]

    Rambaut, Andrew

    FEATURE ARTICLE 2 Kunde Hospital: Nepal WORK IN PROGRESS 4 Public Health in Ceylon Medical research of the Mt Everest area in Nepal who have played such an important role in Himalayan mountaineering century the region became incorporated into the Gorkha kingdom that now forms the modern nation of Nepal

  3. Chronic Copper Poisoning in Sheep.

    E-Print Network [OSTI]

    Boughton, I. B. (Ivan Bertrand); Hardy, W. T. (William Tyree)

    1934-01-01T23:59:59.000Z

    urine, loss of ap- petite, and weakness. Once the symptoms appear, the discase runs a rapid course and terminates fatally in the great majority of cases. Probably many sheep suffer from a subclinical type of the disease which is manifested... the urine a few days after feedin of the copper salt was discontinued but small amounts of copper oxid continued to be excreted daily with the feces for weeks or months. They *All cooper analyses reported in this paper were made in the laboratory...

  4. assiut university hospitals: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ENERGY COMMISSION SPECIAL DISTRICTS HOSPITALS & PUBLIC CARE COLLEGES & UNIVERSITIES Energy Storage, Conversion and Utilization Websites Summary: CALIFORNIA ENERGY COMMISSION...

  5. Coordinating Pediatric Medical Care during an Influenza Pandemic - Hospital Workbook

    SciTech Connect (OSTI)

    HCTT CHE

    2010-01-01T23:59:59.000Z

    This workbook is intended to assist hospitals with coordinating medical care for pediatric influenza-like illness across their community.

  6. E-Print Network 3.0 - admitting department hospital Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Abstract (298 words) Hospital reform... private companies providing health care services: hospital design, medical equipment, ... Source: Ecole Polytechnique,...

  7. Hospital ventilation standards and energy conservation: chemical contamination of hospital air. Final report

    SciTech Connect (OSTI)

    Rainer, D.; Michaelsen, G.S.

    1980-03-01T23:59:59.000Z

    In an era of increasing energy conservation consciousness, a critical reassessment of the validity of hospital ventilation and thermal standards is made. If current standards are found to be excessively conservative, major energy conservation measures could be undertaken by rebalancing and/or modification of current HVAC systems. To establish whether or not reducing ventilation rates would increase airborne chemical contamination to unacceptable levels, a field survey was conducted to develop an inventory and dosage estimates of hospital generated airborne chemical contaminants to which patients, staff, and visitors are exposed. The results of the study are presented. Emphasis is on patient exposure, but an examination of occupational exposure was also made. An in-depth assessment of the laboratory air environment is documented. Housekeeping products used in survey hospitals, hazardous properties of housekeeping chemicals and probable product composition are discussed in the appendices.

  8. Computed tomographic studies of the head in a teaching hospital and a community hospital: a comparison

    SciTech Connect (OSTI)

    McNeil, B.J.; Kirkwood, J.R.; Hanley, J.A.; Polak, J.; Wilkinson, R.; Funkenstein, H.H.

    1982-11-01T23:59:59.000Z

    This investigation compared the use of computed tomography (CT) of the head at a large primary medical-school-affiliated hospital and at a large community hospital. There were two aims: first, to study the intrinsic characteristics of the patients in an attempt to determine the protential for developing accurate discrimination algorithms; and second, to study the patterns of neurodiagnostic tests used at these facilities. The results indicated that separability of patients into normal and abnormal categories at both institutions was extremely small. In addition, there was no significant difference in the numbers or types of ancillary tests used at both institutions. Overall, these data once more confirm the difficulty of altering CT usage patterns in primary or secondary hospitals without significantly affecting the number of abnormal patients identified.

  9. Systemic lupus erythematosus with generalized chronic cutaneous (discoid) lupus erythematosus

    E-Print Network [OSTI]

    Dadlani, Chicky; Pulitzer, Melissa; Prystowsky, Stephen D

    2008-01-01T23:59:59.000Z

    lupus erythematosus (DLE): a clinical and laboratoryLE. Chronic cutaneous DLE affects twice as many women as it2 ]. Chronic cutaneous DLE begins as red-purple macules,

  10. Chronic respiratory effects of indoor formaldehyde exposure

    SciTech Connect (OSTI)

    Krzyzanowski, M.; Quackenboss, J.J.; Lebowitz, M.D. (Univ. of Arizona Health Sciences Center, Tucson (USA))

    1990-08-01T23:59:59.000Z

    The relation of chronic respiratory symptoms and pulmonary function to formaldehyde (HCHO) in homes was studied in a sample of 298 children (6-15 years of age) and 613 adults. HCHO measurements were made with passive samplers during two 1-week periods. Data on chronic cough and phlegm, wheeze, attacks of breathlessness, and doctor diagnoses of chronic bronchitis and asthma were collected with self-completed questionnaires. Peak expiratory flow rates (PEFR) were obtained during the evenings and mornings for up to 14 consecutive days for each individual. Significantly greater prevalence rates of asthma and chronic bronchitis were found in children from houses with HCHO levels 60-120 ppb than in those less exposed, especially in children also exposed to environmental tobacco smoke. In children, levels of PEFR decreased linearly with HCHO exposure, with the estimated decrease due to 60 ppb of HCHO equivalent to 22% of PEFR level in nonexposed children. The effects in asthmatic children exposed to HCHO below 50 ppb were greater than in healthy ones. The effects in adults were less evident: decrements in PEFR due to HCHO over 40 ppb were seen only in the morning, and mainly in smokers.

  11. Inside Alzheimer's Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    reveal conditions that lead to the disease's signature tangles and plaques in the brain March 12, 2015 Inside Alzheimer's Disease Neuron membrane disruption may underlie...

  12. Digit frequency in the hospital! Designing for the task: What numbers are really used in hospitals?!

    E-Print Network [OSTI]

    Subramanian, Sriram

    .wiseman@cs.ucl.ac.uk The task and the problem! Medical workers program infusion pumps to administer drug treatments to patients. This involves entering the volume and rate of medication to be infused. ! ! Occasionally errors are made during into infusion pumps on the ward? Logs from pumps were collected from four different wards in one hospital

  13. Jackson Park Hospital Green Building Medical Center

    SciTech Connect (OSTI)

    William Dorsey; Nelson Vasquez

    2010-03-31T23:59:59.000Z

    Jackson Park Hospital completed the construction of a new Medical Office Building on its campus this spring. The new building construction has adopted the City of Chicago's recent focus on protecting the environment, and conserving energy and resources, with the introduction of green building codes. Located in a poor, inner city neighborhood on the South side of Chicago, Jackson Park Hospital has chosen green building strategies to help make the area a better place to live and work. The new green building houses the hospital's Family Medicine Residency Program and Specialty Medical Offices. The residency program has been vital in attracting new, young physicians to this medically underserved area. The new outpatient center will also help to allure needed medical providers to the community. The facility also has areas designated to women's health and community education. The Community Education Conference Room will provide learning opportunities to area residents. Emphasis will be placed on conserving resources and protecting our environment, as well as providing information on healthcare access and preventive medicine. The new Medical Office Building was constructed with numerous energy saving features. The exterior cladding of the building is an innovative, locally-manufactured precast concrete panel system with integral insulation that achieves an R-value in excess of building code requirements. The roof is a 'green roof' covered by native plantings, lessening the impact solar heat gain on the building, and reducing air conditioning requirements. The windows are low-E, tinted, and insulated to reduce cooling requirements in summer and heating requirements in winter. The main entrance has an air lock to prevent unconditioned air from entering the building and impacting interior air temperatures. Since much of the traffic in and out of the office building comes from the adjacent Jackson Park Hospital, a pedestrian bridge connects the two buildings, further decreasing the amount of unconditioned air that enters the office building. The HVAC system has an Energy Efficiency Rating 29% greater than required. No CFC based refrigerants were used in the HVAC system, thus reducing the emission of compounds that contribute to ozone depletion and global warming. In addition, interior light fixtures employ the latest energy-efficient lamp and ballast technology. Interior lighting throughout the building is operated by sensors that will automatically turn off lights inside a room when the room is unoccupied. The electrical traction elevators use less energy than typical elevators, and they are made of 95% recycled material. Further, locally manufactured products were used throughout, minimizing the amount of energy required to construct this building. The primary objective was to construct a 30,000 square foot medical office building on the Jackson Park Hospital campus that would comply with newly adopted City of Chicago green building codes focusing on protecting the environment and conserving energy and resources. The energy saving systems demonstrate a state of the-art whole-building approach to energy efficient design and construction. The energy efficiency and green aspects of the building contribute to the community by emphasizing the environmental and economic benefits of conserving resources. The building highlights the integration of Chicago's new green building codes into a poor, inner city neighborhood project and it is designed to attract medical providers and physicians to a medically underserved area.

  14. Atmospheric fluidized-bed combustion (AFBC) co-firing of coal and hospital waste. Environmental Assessment

    SciTech Connect (OSTI)

    Not Available

    1993-02-01T23:59:59.000Z

    The proposed project involves co-firing of coal and medical waste (including infectious medical waste) in an atmospheric fluidized-bed combustor (AFBC) to safely dispose of medical waste and produce steam for hospital needs. Combustion at the design temperature and residence time (duration) in the AFBC has been proven to render infectious medical waste free of disease producing organisms. The project would be located at the Veterans Affairs (VA) Medical Center in Lebanon, Pennsylvania. The estimated cost of the proposed AFBC facility is nearly $4 million. It would be jointly funded by DOE, Veterans Affairs, and Donlee Technologies, Inc., of York, Pennsylvania, under a cooperative agreement between DOE and Donlee. Under the terms of this agreement, $3.708 million in cost-shared financial assistance would be jointly provided by DOE and the Veterans Affairs (50/50), with $278,000 provided by Donlee. The purposes of the proposed project are to: (1) provide the VA Medical Center and the Good Samaritan Hospital (GSH), also of Lebanon, Pennsylvania, with a solution for disposal of their medical waste; and (2) demonstrate that a new coal-burning technology can safely incinerate infectious medical waste, produce steam to meet hospital needs, and comply with environmental regulations.

  15. asistieron al hospital: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: Nosocomial transmission of pertussis in hospitals among patients, health care workers (HCWs), or both, poses a high risk of transmission to children without immunity...

  16. al hospital regional: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    U866, pulmonary embolism, procedures related to postpartum8 hemorrhages, and intensive care - in administrative hospital discharge data and medical9 records and compared their...

  17. adosado al hospital: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    medical errors Hos04. Lin00 asserts that "the problem is not bad people in health a smart hospital by optimizing business processes, reducing errors and improving patient...

  18. Department of Energy Announces the Launch of the Hospital Energy...

    Energy Savers [EERE]

    of advanced energy efficiency and renewable technologies in hospital design, construction, retrofit, operations, and maintenance. DOE's Richard F. Moorer joined American...

  19. Hospital Energy Benchmarking Guidance - Version 1.0

    E-Print Network [OSTI]

    Singer, Brett C.

    2010-01-01T23:59:59.000Z

    important for the cooling system (supply and return flows)hospital building - Cooling water supply/return from centralhospital building - Cooling water supply/return from central

  20. Building Green in Greensburg: Kiowa County Memorial Hospital

    Office of Energy Efficiency and Renewable Energy (EERE)

    This poster highlights energy efficiency, renewable energy, and sustainable features of the high-performing Kiowa County Memorial Hospital building in Greensburg, Kansas.

  1. Rebuilding it Better: Greensburg, Kansas, Kiowa County Memorial Hospital (Brochure)

    SciTech Connect (OSTI)

    Not Available

    2010-03-01T23:59:59.000Z

    This brochure details the sustainable and green aspects of the LEED Platinum-designed Kiowa County Memorial Hospital in Greensburg, Kansas.

  2. al hospital rural: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    health Hartman, Chris 2 Critical access hospitals (CAHs) are essential to rural health care and play an important role in its Engineering Websites Summary: - 1 -...

  3. acutely hospitalized elderly: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Samaritan Hospital, an acute-care medical facility to a nationally recognized leader in health care. By leveraging its core competency of building loyal, features the highest...

  4. acute hospital care: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Samaritan Hospital, an acute-care medical facility to a nationally recognized leader in health care. By leveraging its core competency of building loyal, features the highest...

  5. acute public hospitals: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Samaritan Hospital, an acute-care medical facility to a nationally recognized leader in health care. By leveraging its core competency of building loyal, features the highest...

  6. acute care hospital: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Samaritan Hospital, an acute-care medical facility to a nationally recognized leader in health care. By leveraging its core competency of building loyal, features the highest...

  7. acute care hospitals: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Samaritan Hospital, an acute-care medical facility to a nationally recognized leader in health care. By leveraging its core competency of building loyal, features the highest...

  8. acute hospital services: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Samaritan Hospital, an acute-care medical facility to a nationally recognized leader in health care. By leveraging its core competency of building loyal, features the highest...

  9. Title: Chronic hepatitis C virus infection: does it really impact health-related quality of life? A study in rural Egypt.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    of life? A study in rural Egypt. Michaël Schwarzinger1 , Sahar Dewedar2 , Claire Rekacewicz3 , Khaled, Faculty of Medicine, Ain Shams University, Cairo, Egypt, 3 Emerging Disease Epidemiology Unit, Institut chronically infected with HCV in rural Egypt and a higher morbidity amongst uninfected controls as compared

  10. Molecular Bioinformatics for Diseases

    E-Print Network [OSTI]

    Radivojac, Predrag

    . Curr Opin Pediatr, 13: 22 (2001). Leads to sickle cell anemia Manifestation of disease vastly different

  11. Polish-American Children's Hospital in Krakow, Poland

    SciTech Connect (OSTI)

    Secrest, T.J.; Szydlowski, R.F. (Pacific Northwest Lab., Richland, WA (United States)); Wade, D. (RDA Engineering, Inc., Marietta, GA (United States))

    1993-03-01T23:59:59.000Z

    In late 1990 staff from the US Department of Energy's Office of Technical and Financial Assistance identified the Polish-American Children's Hospital as a potential site for application of DOE expertise to reduce the Hospital's energy requirements. Visits to the hospital in the fall and winter of 1991--1992 provided initial scoping of the energy related activities that would be supported by DOE. In addition to reducing energy requirements, the Hospital staff expressed a need for assistance in the areas of power quality and medical waste incineration. Subsequently, a power quality study supported by the Electric Power and Research Institute has been initiated and medical waste incineration will be provided by a Polish organization. The resulting scope of work for this effort is to survey the Hospital's thermal energy supply and demand systems to identify no-cost and low-cost measures that will reduce the Hospital's energy requirements. Applicable measures would then be demonstrated in the Hospital through a partnership with US and Polish organizations and a sister hospital in the United States.

  12. Dimensioning hospital wards using the Erlang loss model Corresponding author

    E-Print Network [OSTI]

    -2006. Finally, we demonstrate the efficiency of merging departments. Keywords: hospital resource allocationDimensioning hospital wards using the Erlang loss model Corresponding author: A.M. de Bruin (MSc of Sciences Department of Mathematics Assistant professor Optimization of Business Processes L. van Zanten

  13. Forecasting Hospital Bed Availability Using Simulation and Neural Networks

    E-Print Network [OSTI]

    Kuhl, Michael E.

    Forecasting Hospital Bed Availability Using Simulation and Neural Networks Matthew J. Daniels, NY 14623 Elisabeth Hager Hager Consulting Pittsford, NY 14534 Abstract The availability of beds is a critical factor for decision-making in hospitals. Bed availability (or alternatively the bed occupancy

  14. Improving Hand Hygiene in the Johns Hopkins Hospital

    E-Print Network [OSTI]

    von der Heydt, Rüdiger

    Improving Hand Hygiene in the Johns Hopkins Hospital Adult Emergency Department Compliance with hand hygiene before and after every patient interaction in the hospital is an integral component to indicate that hand hygiene reduces healthcare-associated infections.The CDC and the World Health

  15. Paper Number 20 Organizational model of a hospital system

    E-Print Network [OSTI]

    Bruneau, Michel

    Paper Number 20 Organizational model of a hospital system G.P. Cimellaro Department of Civil of a hospital network has been estimated using an organizational metamodel that is able to incorporate the influence of facility damage of structural and no-structural components on the organizational system

  16. Evaluation of Miscellaneous and Electronic Device Energy Use in Hospitals

    E-Print Network [OSTI]

    1 Evaluation of Miscellaneous and Electronic Device Energy Use in Hospitals Douglas R and Electronic Device Energy Use in Hospitals Douglas R. Black*, Steven M. Lanzisera, Judy Lai, Richard E. Brown@lbl.gov, REBrown@lbl.gov, and BCSinger@lbl.gov *Corresponding Author Abstract: Miscellaneous and electronic loads

  17. Blood Drive Coordinator Packet Massachusetts General Hospital pg.2

    E-Print Network [OSTI]

    Mootha, Vamsi K.

    1 Blood Drive Coordinator Packet Massachusetts General Hospital pg.2 The MGH Bloodmobile pg.3 Facts about Blood Donation pg.4 Spreading the Word pg.5 Frequently Asked Questions and Tips pg.7 Schedule a Blood Drive pg.10 Eligibility Guidelines pg.11 #12;2 Massachusetts General Hospital

  18. Trinity Health Ireland AMNCH TCD St James's Hospital

    E-Print Network [OSTI]

    O'Mahony, Donal E.

    Page1 Trinity Health Ireland AMNCH TCD St James's Hospital THE UNIVERSITY OF DUBLIN Trinity College / Trinity College 3 3. The Faculty of Health Sciences and School of Medicine 4 4. Adelaide and Meath. Trinity College, Dublin ­ Discipline of Clinical Medicine 10 at St. James's Hospital 7. Position

  19. Automated Detection of Infectious Disease Outbreaks in Hospitals: A Retrospective Cohort Study

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    Kleinman K, Lazarus R, Platt R (2004) A generalized linearJulie Dunn 5 , Richard Platt 2,5 1 Division of InfectiousMIDAS, 1U01 GM076672, Platt; (http://www.nigms.nih.gov/

  20. Automated Detection of Infectious Disease Outbreaks in Hospitals: A Retrospective Cohort Study

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    MRSA) Antibiotic profile N S. aureus (MRSA) Ward N S.aureus (MRSA) Ward Y S.aureus (MRSA) d Ward N S. aureus (MRSA) d Service N S.

  1. Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease

    E-Print Network [OSTI]

    Chang, Ruey-Kang R.; Chen, Alex Y.

    2010-01-01T23:59:59.000Z

    Furthermore, there might be off-label use of Synagis in HS-to assess the extent of off-label use before 2003. Despite

  2. A case report of motor neuron disease in a patient showing significant level of DDTs, HCHs and organophosphate metabolites in hair as well as levels of hexane and toluene in blood

    SciTech Connect (OSTI)

    Kanavouras, Konstantinos [Department of Neurology, Medical School, University of Crete, Heraklion, Crete (Greece)] [Department of Neurology, Medical School, University of Crete, Heraklion, Crete (Greece); Tzatzarakis, Manolis N. [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece)] [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece); Mastorodemos, Vasileios; Plaitakis, Andreas [Department of Neurology, Medical School, University of Crete, Heraklion, Crete (Greece)] [Department of Neurology, Medical School, University of Crete, Heraklion, Crete (Greece); Tsatsakis, Aristidis M., E-mail: aris@med.uoc.gr [Center of Toxicology Science and Research, University of Crete, Heraklion, Crete (Greece)

    2011-11-15T23:59:59.000Z

    Motor neuron disease is a devastating neurodegenerative condition, with the majority of sporadic, non-familial cases being of unknown etiology. Several epidemiological studies have suggested that occupational exposure to chemicals may be associated with disease pathogenesis. We report the case of a patient developing progressive motor neuron disease, who was chronically exposed to pesticides and organic solvents. The patient presented with leg spasticity and developed gradually clinical signs suggestive of amyotrophic lateral sclerosis, which was supported by the neurophysiologic and radiological findings. Our report is an evidence based case of combined exposure to organochlorine (DDTs), organophosphate pesticides (OPs) and organic solvents as confirmed by laboratory analysis in samples of blood and hair confirming systematic exposure. The concentration of non-specific dialkylphosphates metabolites (DAPs) of OPs in hair (dimethyphopshate (DMP) 1289.4 pg/mg and diethylphosphate (DEP) 709.4 pg/mg) and of DDTs (opDDE 484.0 pg/mg, ppDDE 526.6 pg/mg, opDDD 448.4 pg/mg, ppDDD + opDDT 259.9 pg/mg and ppDDT 573.7 pg/mg) were considerably significant. Toluene and n-hexane were also detected in blood on admission at hospital and quantified (1.23 and 0.87 {mu}g/l, respectively), while 3 months after hospitalization blood testing was found negative for toluene and n-hexane and hair analysis was provided decrease levels of HCHs, DDTs and DAPs. -- Highlights: Black-Right-Pointing-Pointer Exposure to pesticides and organic solvents might be a risk factor for sporadic MND. Black-Right-Pointing-Pointer We report a patient who developed progressive upper and lower motor neuron disease. Black-Right-Pointing-Pointer The patient had a history of occupational exposure to pesticides and solvents. Black-Right-Pointing-Pointer High DDTs' levels and increased levels of DMP and DEP were measured in his hair. Black-Right-Pointing-Pointer The patients' exposure to chemicals might have played a role in MND development.

  3. ameliorates chronic epicutaneous: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    obstructive uropathy.Autonomic neuropathy is well associated with chronic renal failure patients. Knowledge of autonomic dysfunction canencourage patients and physicians to...

  4. ameliorates chronic hyperprolactinemia: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    obstructive uropathy.Autonomic neuropathy is well associated with chronic renal failure patients. Knowledge of autonomic dysfunction canencourage patients and physicians to...

  5. adolescent illness chronic: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    patients with a chronic illness, they eventually undergo the transition from paediatric health care to adult health care. This transition typically occurs simultaneously with...

  6. Chronic renal failure with gout: a marker of chronic lead poisoning

    SciTech Connect (OSTI)

    Craswell, P.W.; Price, J.; Boyle, P.D.; Heazlewood, V.J.; Baddeley, H.; Lloyd, H.M.; Thomas, B.J.; Thomas, B.W.

    1984-09-01T23:59:59.000Z

    EDTA (calcium disodium edetate) lead mobilization and x-ray fluorescence (XRF) finger bone lead tests were done in 42 patients with chronic renal failure and without persisting lead intoxication. Nineteen of 23 patients with gout and 8 of 19 without gout had positive EDTA lead mobilization tests. Those patients with gout excreted significantly more excess lead chelate than those without gout. In the gout group 17 patients denied any childhood or industrial exposure to lead. They had a greater number of positive tests and excreted significantly more excess lead chelate than 14 patients with neither gout nor lead exposure. These results confirm that gout in the presence of chronic renal failure is a useful marker of chronic lead poisoning. Of 27 patients with positive lead mobilization tests, only 13 had elevated XRF finger bone lead concentrations (sensitivity 48%). Three of 15 patients with negative lead mobilization tests had elevated XRF finger bone lead concentrations (specificity 80%). Although the XRF finger bone lead test is a convenient noninvasive addition to the diagnostic evaluation of patients with chronic renal failure and gout, its application is limited due to the lack of sensitivity of the method.

  7. Incidence of Negative Appendectomy: Experience From a Company Hospital in Nigeria

    E-Print Network [OSTI]

    Osime, O C; Ajayi, P A

    2005-01-01T23:59:59.000Z

    From a Company Hospital in Nigeria OC Osime, FMCS, FICSHospital Benin City, Nigeria ABSTRACT Objective: The aim ofin a company hospital in Nigeria. Background: Appendicitis

  8. Cardiovascular Disease (CVD) Coronary heart disease

    E-Print Network [OSTI]

    Dever, Jennifer A.

    have a greater prevalence in women · Osteoporosis · Autoimmune disease A. Osteoporosis · Osteoporosis ­ disorder of low bone mass, microarchitectural denegra7on% of all women >65 years old have osteoporosis (15% of all Caucasian women

  9. Asymptomatic Chronic Dislocation of a Cemented Total Hip Prosthesis

    E-Print Network [OSTI]

    Salvi, Andrea Emilio; Florschutz, Anthony Vatroslav; Grappiolo, Guido

    2014-01-01T23:59:59.000Z

    Dislocation of Hip Prosthesis dislocation after total hipa Cemented Total Hip Prosthesis * Mellino Mellini HospitalDislocation of a total hip prosthesis is a painful and

  10. Evaluation of the serum catalase and myeloperoxidase activities in chronic arsenic-exposed individuals and concomitant cytogenetic damage

    SciTech Connect (OSTI)

    Banerjee, Mayukh; Banerjee, Nilanjana; Ghosh, Pritha [Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Kolkata (India); Das, Jayanta K. [Department of Dermatology, West Bank Hospital, Howrah (India); Basu, Santanu [Department of General Medicine, Sri Aurobindo Seva Kendra, Kolkata (India); Sarkar, Ajoy K. [Peerless Hospital and B.K Roy Research Centre, Kolkata (India); States, J. Christopher, E-mail: jcstates@louisville.ed [Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY (United States); Center for Environmental Genomics and Integrative Biology, University of Louisville, Louisville, KY (United States); Giri, Ashok K., E-mail: akgiri15@yahoo.co [Molecular and Human Genetics Division, Indian Institute of Chemical Biology, Kolkata (India)

    2010-11-15T23:59:59.000Z

    Chronic arsenic exposure through contaminated drinking water is a major environmental health issue. Chronic arsenic exposure is known to exert its toxic effects by a variety of mechanisms, of which generation of reactive oxygen species (ROS) is one of the most important. A high level of ROS, in turn, leads to DNA damage that might ultimately culminate in cancer. In order to keep the level of ROS in balance, an array of enzymes is present, of which catalase (CAT) and myeloperoxidase (MPO) are important members. Hence, in this study, we determined the activities of these two enzymes in the sera and chromosomal aberrations (CA) in peripheral blood lymphocytes in individuals exposed and unexposed to arsenic in drinking water. Arsenic in drinking water and in urine was used as a measure of exposure. Our results show that individuals chronically exposed to arsenic have significantly higher CAT and MPO activities and higher incidence of CA. We found moderate positive correlations between CAT and MPO activities, induction of CA and arsenic in urine and water. These results indicate that chronic arsenic exposure causes higher CAT and MPO activities in serum that correlates with induction of genetic damage. We conclude that the serum levels of these enzymes might be used as biomarkers of early arsenic exposure induced disease much before the classical dermatological symptoms of arsenicosis begin to appear.

  11. Dynamical changes in neurological diseases and anesthesia Michelle M McCarthy1

    E-Print Network [OSTI]

    Kopell, Nancy

    Dynamical changes in neurological diseases and anesthesia Michelle M McCarthy1 , ShiNung Ching1 within the networks known to be relevant to each disorder. We also discuss anesthesia, since Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit St., GRJ

  12. THE UNIVERSITY OF CONNECTICUT HEALTH CENTER JOHN DEMPSEY HOSPITAL

    E-Print Network [OSTI]

    Oliver, Douglas L.

    Mandibular condyle prosthesis Operating Room Temporomandibular joint (TMJ) prosthesis Operating Room. PROCEDURE: A. DELEGATION OF RESPONSIBILITY & OFFICIAL CONTACT PERSON The Chief Operating Officer for John: Chief Operating Officer for John Dempsey Hospital UCHC Safety Officer Director of Clinical Engineering

  13. Improving product availability in hospitals : the role of inventory inaccuracies

    E-Print Network [OSTI]

    Opolon, David C. (David Cyrille)

    2010-01-01T23:59:59.000Z

    All players in the healthcare industry face increasing public and political pressure to improve quality of care and control costs. Hospitals, on the frontline of this challenge, face nursing shortages and financial ...

  14. Continuous Commissioning® Opportunities in Hospital and Laboratory Facilities

    E-Print Network [OSTI]

    Jones, A.; Claridge, D. E.; Turner, W. D.; Deng, S.; Wei, G.; Zeig, G.

    This paper compiles the Continuous Commissioning® (CC®) costs, savings, and opportunities implemented in 20 hospital and laboratory commissioning projects involving 48 buildings. The potential savings and costs from 25 CC assessments of 36 buildings...

  15. Application of Thermal Storage, Peak Shaving and Cogeneration for Hospitals

    E-Print Network [OSTI]

    McClure, J. D.; Estes, J. M.; Estes, M. C.

    1987-01-01T23:59:59.000Z

    Energy costs of hospitals can be managed by employing various strategies to control peak electrical demand (KW) while at the same time providing additional security of operation in the event that an equipment failure or a disruption of power from...

  16. Energy Use and Costs in Texas Schools and Hospitals

    E-Print Network [OSTI]

    Dunn, J. R.

    1998-01-01T23:59:59.000Z

    Procedures are presented for documenting and graphically presenting the monthly and annual energy use and costs for schools and hospitals. Collected data include monthly electrical energy consumed, monthly total electrical cost, monthly electrical...

  17. Evaluation of Acute and Chronic Lesions in Percutaneous Coronary Intervention

    E-Print Network [OSTI]

    Roberts, Aaron

    2012-10-19T23:59:59.000Z

    EVALUATION OF ACUTE AND CHRONIC LESIONS IN PERCUTANEOUS CORONARY INTERVENTION A Thesis by AARON WHEELER ROBERTS Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE August 2012 Major Subject: Biomedical Sciences Evaluation of Acute and Chronic Lesions in Percutaneous Coronary Intervention Copyright 2012 Aaron Wheeler Roberts...

  18. I am extremely pleased to extend my greetings on the publication of Kyoto University Hospital's Guidance 2013. Kyoto University Hospital

    E-Print Network [OSTI]

    Takada, Shoji

    robot Da Vinci has been operating smoothly, and is producing solid results. The Rheumatism Center. Meanwhile, the Division for iPS Cell Application Development, which was set up inside the hospital in 2011

  19. Visual Exploration of Time-oriented Patient Data for Chronic Diseases

    E-Print Network [OSTI]

    promises in turning data deluge into improved quality of medical care. Yet, patient data management systems. In an effort to turn data deluge into improved quality of medical care, we present a design study

  20. Chronic Fatigue Syndrome As An Agent of Infectious Disease: A Review of Etiological Agents

    E-Print Network [OSTI]

    Hassenberg, Amy

    2011-01-01T23:59:59.000Z

    Syndrome. ” Science Patarca-Montero, Roberto. Medicalto this syndrome (Patarca-Montero 2004). It is not just a

  1. Use of a Soluble Epoxide Hydrolase Inhibitor in Smoke-Induced Chronic Obstructive Pulmonary Disease

    E-Print Network [OSTI]

    Hammock, Bruce D.

    of the lungs character- ized by progressive and largely irreversible airflow limitation attribu- table) to reduce lung injury and inflammation after subacute exposure to tobacco smoke over a period of 4 weeks lavage. sEHI t-TUCB suppressed IFN-g, while improving lung function by reducing tobacco smoke

  2. Intravenous Allogeneic Adipose-derived Mesenchymal Stem Cell Treatment of Stage IV Chronic Kidney Disease Cats

    E-Print Network [OSTI]

    Collett Jr., Jeffrey L.

    in the body (particularly in the lungs). This is why the cells are diluted in a solution and the injection

  3. Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthma

    E-Print Network [OSTI]

    Dam, T.-T.; Harrison, S.; Fink, H. A.; Ramsdell, J.; Barrett-Connor, E.

    2010-01-01T23:59:59.000Z

    x ORIGINAL ARTICLE Bone mineral density and fractures inwas associated with lower bone mineral density (BMD) at theKeywords Bone loss . Bone mineral density . Elderly .

  4. Highly Efficient Amplification of Chronic Wasting Disease Agent by Protein Misfolding Cyclic Amplification with

    E-Print Network [OSTI]

    Amplification with Beads (PMCAb) Chad J. Johnson1 , Judd M. Aiken2 , Debbie McKenzie2 , Michael D. Samuel3. Citation: Johnson CJ, Aiken JM, McKenzie D, Samuel MD, Pedersen JA (2012) Highly Efficient Amplification

  5. Quality Adjustment for Health Care Spending on Chronic Disease: Evidence from Diabetes Treatment, 1999–2009

    E-Print Network [OSTI]

    Eggleston, Karen N

    Although US health care expenditures reached 17.6 percent of GDP in 2009, quality measurement in this important service sector remains limited. Studying quality changes associated with 11 years of health care for patients ...

  6. New Functional Imaging Technology to Differentiate between Chronic Obstructive Pulmonary Disease and Heart Failure

    E-Print Network [OSTI]

    Pollack, Charles V.; Slattery, David E

    2011-01-01T23:59:59.000Z

    improvement of congestive heart failure: a pilot study. BMCtesting and the accuracy of heart failure diagnosis in theemergency department. Circ Heart Fail. 2010 Jan;3(1):104-10.

  7. Consequences and therapy of the metabolic acidosis of chronic kidney disease

    E-Print Network [OSTI]

    Kraut, Jeffrey A.; Madias, Nicolaos E.

    2011-01-01T23:59:59.000Z

    diuretics or the use of calcium carbonate or calcium citratehand, if the individual is receiving calcium carbonate,calcium citrate, or sevelamer carbonate, base administration

  8. Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthma

    E-Print Network [OSTI]

    Dam, T.-T.; Harrison, S.; Fink, H. A.; Ramsdell, J.; Barrett-Connor, E.

    2010-01-01T23:59:59.000Z

    risk of vertebral osteoporosis compared to men with noto identify patients with osteoporosis. Keywords Bone loss .associated with COPD, osteoporosis is believed to affect 36%

  9. Curriculum for M.S. Public Health: Chronic Disease Epidemiology Track

    E-Print Network [OSTI]

    Lee, Daeyeol

    Topics in Multicenter Clinical Trials 1 BIS 643b, Theory of Survival Analysis and its Applications 1 BIS Survival Analysis 1 CDE 508a, Principles of Epidemiology I 1 CDE 516b, Principles of Epidemiology II 1 CDE

  10. Prediction of Chronic Obstructive Pulmonary Disease (COPD) in Asthma Patients Using Electronic Medical Records

    E-Print Network [OSTI]

    Dai, Yi

    Objective: Identify clinical factors that modulate the risk of progression to COPD among asthma patients using data extracted from electronic medical records.

  11. Survival after bilateral lung transplantation versus single lung transplantation for patients with chronic obstructive pulmonary disease.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Survival after bilateral lung transplantation versus single lung transplantation for patients, Pennsylvania, USA. 8 International Heart and Lung Transplant Registry, Addison, Texas. Word count: 3204 Background: Both single and bilateral lung transplantation (LT) are recognized options for patients with end

  12. Update on the Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron SpinPrinceton PlasmaAfternoon TalksDigitalRevision toNetwork

  13. Update on the Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron SpinPrinceton PlasmaAfternoon TalksDigitalRevision toNetworkMay 9, 2013

  14. Update on the Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron SpinPrinceton PlasmaAfternoon TalksDigitalRevision toNetworkMay 9, 2013

  15. Independent Oversight Inspection of the Hanford Site Chronic Beryllium Disease Prevention Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh SchoolIn Other News Community Connections:HAZARD| Department

  16. Does aluminum smelting cause lung disease

    SciTech Connect (OSTI)

    Abramson, M.J.; Wlodarczyk, J.H.; Saunders, N.A.; Hensley, M.J.

    1989-04-01T23:59:59.000Z

    The evidence concerning a relationship between work in the aluminum industry and lung disease has been reviewed using epidemiologic criteria. Adequate data on environmental exposure are rarely presented. Case series on aluminum potroom workers over the past 50 years have identified an asthmalike syndrome that appears to be due to an irritant rather than an allergic mechanism. These studies have been supported by evidence of within shift variability of measures of lung function. However, to date, there is inadequate evidence to resolve the question of whether potroom exposure initiates asthma or merely precipitates asthmalike symptoms in a predisposed individual. Cross-sectional studies have demonstrated evidence of reduced lung function, consistent with chronic airflow limitation. In exposed aluminum smelter workers compared to unexposed control subjects. Cigarette smoking, the major potential confounding variable, has been measured and accounted for in multivariate analyses. To date, evidence is lacking from longitudinal studies about the development of disabling chronic obstructive lung disease. Exposure to coal tar pitch volatiles in the production and consumption of anodes has biologic plausibility for an association of lung cancer with work in an aluminum smelter. Although retrospective mortality studies have failed to account for the probable high prevalence of smoking in blue collar workers, the relative risk of lung cancer is very low if present at all. Pulmonary fibrosis has not been shown to be a significant problem in aluminum smelter workers. Future research in the aluminum industry needs to concentrate on longitudinal studies, preferably with an inception cohort for the investigation of potroom asthma. 92 references.

  17. Computed tomography of the spleen and liver in sickle cell disease

    SciTech Connect (OSTI)

    Magid, D.; Fishman, E.K.; Siegelman, S.S.

    1984-08-01T23:59:59.000Z

    The spleen was assessed in 10 patients with sickle cell disease studied with computed tomography (CT) for abdominal pain and/or unexplained fever. Patients with homozygous sickle cell anemia were found to have small, densely calcified spleens with occasional low-density infarcts. Five of six had hepatomegaly, and there was one case each of hepatic abscess, infarcts, and hemochromatosis. All patients with heterozygous sickle cell disease were found to have splenomegaly, with a variety of findings including acute hemorrhage, acute and chronic infarcts, rupture, and possible sequestration. It was concluded that CT is useful for evaluating the status of the spleen and liver in symptomatic patients with sickle cell disease.

  18. antigen-positive chronic hepatitis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary: ??abstractChronic hepatitis C virus infection (HCV) affects 180 million people worldwide. Chronic HCV can cause hepatic decompensation, hepatocellular carcinoma...

  19. From the Constitution to the Hospital: Universal Health Care in Thailand 

    E-Print Network [OSTI]

    Mattison, Shawn

    2007-01-01T23:59:59.000Z

    in Implementing Quality Management Systems in Thailand: Asystem requires accredited hospitals to apply Total Quality Management (

  20. Hospital design and face-to-face interaction among clinicians: a theoretical model

    E-Print Network [OSTI]

    Rashid, Mahbub

    2009-07-01T23:59:59.000Z

    fulfill its purposes in hospitals by controlling the interfaces among different communities of clinicians....

  1. Management of Low-Level Radioactive Waste from Research, Hospitals and Nuclear Medical Centers in Egypt - 13469

    SciTech Connect (OSTI)

    Hasan, M.A.; Selim, Y.T.; Lasheen, Y.F. [Hot Labs and Waste Management Center, Atomic Energy Authority, 3 Ahmed El-Zomor St., El-Zohour District, Naser City, 11787, Cairo (Egypt)] [Hot Labs and Waste Management Center, Atomic Energy Authority, 3 Ahmed El-Zomor St., El-Zohour District, Naser City, 11787, Cairo (Egypt)

    2013-07-01T23:59:59.000Z

    The application of radioisotopes and radiation sources in medical diagnosis and therapy is an important issue. Physicians can use radioisotopes to diagnose and treat diseases. Methods of treatment, conditioning and management of low level radioactive wastes from the use of radiation sources and radioisotopes in hospitals and nuclear medicine application, are described. Solid Radioactive waste with low-level activity after accumulation, minimization, segregation and measurement, are burned or compressed in a compactor according to the international standards. Conditioned drums are transported to the interim storage site at the Egyptian Atomic Energy Authority (EAEA) represented in Hot Labs and Waste Management Center (HLWMC) for storage and monitoring. (authors)

  2. Domestic violence is a health care problem of epidemic proportions. In addition to the immediate trauma caused by abuse, domestic violence contributes to a number of chronic health problems,

    E-Print Network [OSTI]

    Derisi, Joseph

    Domestic violence is a health care problem of epidemic proportions. In addition to the immediate trauma caused by abuse, domestic violence contributes to a number of chronic health problems, including depression, alcohol and substance abuse, sexually transmitted diseases such as HIV/AIDS, and often limits

  3. Evaluation of Miscellaneous and Electronic Device Energy Use in Hospitals

    SciTech Connect (OSTI)

    Black, Douglas R.; Lanzisera, Steven M.; Lai, Judy; Brown, Richard E.; Singer, Brett C.

    2012-09-01T23:59:59.000Z

    Miscellaneous and electronic loads (MELs) consume about one-thirdof the primary energy used in US buildings, and their energy use is increasing faster than other end-uses. In healthcare facilities, 30percent of the annual electricity was used by MELs in 2008. This paper presents methods and challenges for estimating medical MELs energy consumption along with estimates of energy use in a hospital by combining device-level metered data with inventories and usage information. An important finding is that common, small devices consume large amounts of energy in aggregate and should not be ignored when trying to address hospital energy use.

  4. Hospital Energy Benchmarking Guidance - Version 1.0

    SciTech Connect (OSTI)

    Singer, Brett C.

    2009-09-08T23:59:59.000Z

    This document describes an energy benchmarking framework for hospitals. The document is organized as follows. The introduction provides a brief primer on benchmarking and its application to hospitals. The next two sections discuss special considerations including the identification of normalizing factors. The presentation of metrics is preceded by a description of the overall framework and the rationale for the grouping of metrics. Following the presentation of metrics, a high-level protocol is provided. The next section presents draft benchmarks for some metrics; benchmarks are not available for many metrics owing to a lack of data. This document ends with a list of research needs for further development.

  5. Adventures in Infectious Diseases

    ScienceCinema (OSTI)

    Fisher-Hoch, Susan [University of Texas School of Public Health

    2014-06-25T23:59:59.000Z

    Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

  6. Impact of Hemodialysis on Lipid Profile among Chronic Renal Failure Patients- A Case Control Study

    E-Print Network [OSTI]

    unknown authors

    Abstract- Chronic Renal Failure (CRF) patients are at risk of cardiovascular diseases due to the elevation of various forms of lipids. Many a time CRF patients live on hemodialysis on regular basis. Present study was done to know whether hemodialysis has any impact on the lipid profile of the CRF patients. Study were divided into 3 groups, Group-I: healthy controls (30), Group-II: CRF patients who never undergone hemodialysis (30) and Group-III: CRF patients on hemodialysis for more than 6 months (30). We obtained serum samples from patients in the morning after an overnight fast and were analyzed for total cholesterol (TC), triglycerides (TGs), HDL, LDL and VLDL. Among the various parameters tested triglyceride and VLDL levels were significantly higher in group-II and III as compared to controls (p?0.01). HDL levels were significantly lower in group-II and III as compared to control (p?0.05). HDL level was found reduced in group-III as compared to Group-II (p?0.01). There was no significant change (p>0.05) observed in total cholesterol and LDL levels in between healthy controls and CRF patients with & without hemodialysis. There was no significant difference (p>0.05) observed between lipid profile in male and female patients in control group and in CRF patients with and without hemodialysis. It is concluded that both male and female patients of CRF with and without hemodialysis have characteristic dyslipidemias without any discrimination of sex and it is not attenuated by the hemodialysis process. Index Terms- Chronic renal failure, hemodialysis, lipid profile, cardiovascular diseases D

  7. Large scale disease prediction

    E-Print Network [OSTI]

    Schmid, Patrick R. (Patrick Raphael)

    2008-01-01T23:59:59.000Z

    The objective of this thesis is to present the foundation of an automated large-scale disease prediction system. Unlike previous work that has typically focused on a small self-contained dataset, we explore the possibility ...

  8. Health & Medicine Heart Disease

    E-Print Network [OSTI]

    Rogers, John A.

    See Also: Health & Medicine Heart Disease· Medical Imaging· Vioxx· Matter & Energy Electronics· Technology· Medical Technology· Reference Artificial heart· Biosensor· Circuit design· Machine· Science and stretchable electronics can map waves of electrical activity in the heart with better resolution and speed

  9. Evaluation of exposures of hospital employees to anesthetic gases

    SciTech Connect (OSTI)

    Lambeth, J.D.

    1988-01-01T23:59:59.000Z

    Hospital employees who work in hospital operating and recovery rooms are often exposed to a number of anesthetic gases. There is evidence to support the belief that such exposures have led to higher rates of miscarriages and spontaneous abortions of pregnancies among women directly exposed to these gases than among women not exposed. Most of the studies assessing exposure levels were conducted prior to the widespread use of scavenging systems. Air sampling was conducted in hospital operatories and recovery rooms of three large hospitals to assess the current exposure levels in these areas and determine the effectiveness of these systems in reducing exposures to fluoride-containing anesthetic gases. It was determined that recovery-room personnel are exposed to levels of anesthesia gases that often approach and exceed the recommended Threshold Limit Value-Time Weighted Average (TLV-TWA) of 2.0 ppm. Recovery-room personnel do not have the protection from exposure provided by scavenging systems in operating rooms. Operating-room personnel were exposed to anesthesia gas levels above the TLV-TWA only when patients were masked, or connected and disconnected from the scavenging systems. Recovery-room personnel also need to be protected from exposure to anesthesia gases by a scavenging system.

  10. THE UNIVERSITY OF CONNECTICUT HEALTH CENTER JOHN DEMPSEY HOSPITAL

    E-Print Network [OSTI]

    Oliver, Douglas L.

    are designed with integrated regulator, contents gauge, flowmeter valve, and carrying handle. These special must be brought into the Hospital through the Receiving Dock or to a designated storage location for identification, proper labeling must also be present. Type of gas Color of Cylinder Air Yellow Carbon Dioxide

  11. CALIFORNIA ENERGY COMMISSION SPECIAL DISTRICTS HOSPITALS & PUBLIC CARE COLLEGES & UNIVERSITIES

    E-Print Network [OSTI]

    Whether you are building a new facility, renovating an existing one, or want to reduce your energy billsCALIFORNIA ENERGY COMMISSION SPECIAL DISTRICTS HOSPITALS & PUBLIC CARE COLLEGES & UNIVERSITIES F O 2004 www.energy.ca.gov/efficiency/partnership Call (916) 654-4147 #12;The Energy Partnership Program

  12. Coming to a hospital near you: mass spectrometry imaging

    ScienceCinema (OSTI)

    Bowen, Ben

    2014-06-24T23:59:59.000Z

    Berkeley Lab's Ben Bowen discusses "Coming to a hospital near you: mass spectrometry imaging" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas. Go here to watch the entire event with all 8 speakers.

  13. Ownership and Hospital Productivity Brigitte Dormont* et Carine Milcent**

    E-Print Network [OSTI]

    Ownership and Hospital Productivity Brigitte Dormont* et Carine Milcent** 1 July, 12, 2012 Abstract quality. This paper proposes an analysis of the differences in productivity and efficiency between French between these two sectors. The purpose of this paper is to compare the productivity of public and private

  14. One of John Dempsey Hospital's new quality improvement tools

    E-Print Network [OSTI]

    Oliver, Douglas L.

    One of John Dempsey Hospital's new quality improvement tools borrows lessons learned from the nuclear power industry, manufac turing and aviation. "Safety is a science. Reliability is a science, is a former Navy pilot. "We're learning specific tools based on high reliability tech niques to improve

  15. Coming to a hospital near you: mass spectrometry imaging

    SciTech Connect (OSTI)

    Bowen, Ben

    2013-10-31T23:59:59.000Z

    Berkeley Lab's Ben Bowen discusses "Coming to a hospital near you: mass spectrometry imaging" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas. Go here to watch the entire event with all 8 speakers.

  16. A survey of access to trial of labor in California hospitals in 2012

    E-Print Network [OSTI]

    Barger, Mary K; Dunn, Jennifer Templeton; Bearman, Sage; DeLain, Megan; Gates, Elena

    2013-01-01T23:59:59.000Z

    of TOLAC hospitals had 24/7 anesthesia coverage and requiredavailable” and that anesthesia be available [5]. Then, in24-hour in-hospital anesthesia should also be available [6].

  17. Skin cancer in albinos at the University of Calabar Teaching Hospital, Calabar, Nigeria

    E-Print Network [OSTI]

    Asuquo, M E; Otei, O O; Omotoso, J; Bassey, E E

    2010-01-01T23:59:59.000Z

    Okoro AN. Albinism in Nigeria. A clinical and social study.Teaching Hospital, Calabar, Nigeria M E Asuquo 1 , O O OteiHospital, Calabar, Nigeria. mauefas@yahoo.com Abstract We

  18. Championed by Residential and Dining Enterprises Stanford Dining and Stanford Hospitality & Auxiliaries

    E-Print Network [OSTI]

    Straight, Aaron

    Championed by Residential and Dining Enterprises Stanford Dining and Stanford Hospitality Administration 3 Stanford Dining and Stanford Hospitality & Auxiliaries 4 From Residential & Dining Enterprises 5 Sustainability Report 3 #12;From Residential & Dining Enterprises "Residential & Dining Enterprises supports

  19. Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms

    E-Print Network [OSTI]

    Prick, Janine; de Haan, Gerald; Green, Anthony R.; Kent, David G.

    2014-09-06T23:59:59.000Z

    tumor initiating cell). Evidence for this latter theory is strongest in acute leukemias, where a rare subpopulation of CSCs is present at the apex of the clonal hierarchy (reviewed in [25]). Since stem cells persist for a long period of time there is a... as three distinct diseases with distinct clinical phenotypes (reviewed in [38]). Still they all share some clinical features, including a chronic course, the risk of major thrombotic events and the risk of transformation to acute leukemia. In particular...

  20. Periodontal Disease and Heart Health

    E-Print Network [OSTI]

    Goldman, Steven A.

    Periodontal Disease and Heart Health Deaf HealthTalks Presenter: Christopher Lehfeldt, DDS Elmwood #12;X-ray showing bone loss rickwilsondmd.typepad.com Thursday, March 15, 12 #12;5. What is heart disease? · The medical name for heart disease is cardiovascular disease (CVD) · An American dies from CVD

  1. Development of design strategies to support evacuation process of hospital buildings in united states

    E-Print Network [OSTI]

    Kader, Sharmin

    2009-05-15T23:59:59.000Z

    for Hospital Evacuation Design Evacuation of any building is a part of Building Fire Protection System. The AIA Guidelines for Design and Construction of Hospitals and Health Care Facilities and JCAHO referred the hospital fire safety to NFPA-101standards... within existing facilities, shall comply with NFPA 101, with the following stipulation. The Fire-Safety Evaluation System (FSES) is permitted in new construction and renovation projects (AIA-2006). b) Hospital Building Evacuation Design Standards...

  2. Blue Shield ensures uninterrupted access to quality medical care after Palm Drive Hospital ceases operations

    E-Print Network [OSTI]

    Ravikumar, B.

    Blue Shield ensures uninterrupted access to quality medical care after Palm Drive Hospital ceases and inpatient services due to the hospital's bankruptcy filing. This closure affects Blue Shield HMO plan members who have been utilizing Palm Drive Hospital services. Please be advised that Blue Shield

  3. Polish-American Children`s Hospital in Krakow, Poland. Project status report

    SciTech Connect (OSTI)

    Secrest, T.J.; Szydlowski, R.F. [Pacific Northwest Lab., Richland, WA (United States); Wade, D. [RDA Engineering, Inc., Marietta, GA (United States)

    1993-03-01T23:59:59.000Z

    In late 1990 staff from the US Department of Energy`s Office of Technical and Financial Assistance identified the Polish-American Children`s Hospital as a potential site for application of DOE expertise to reduce the Hospital`s energy requirements. Visits to the hospital in the fall and winter of 1991--1992 provided initial scoping of the energy related activities that would be supported by DOE. In addition to reducing energy requirements, the Hospital staff expressed a need for assistance in the areas of power quality and medical waste incineration. Subsequently, a power quality study supported by the Electric Power and Research Institute has been initiated and medical waste incineration will be provided by a Polish organization. The resulting scope of work for this effort is to survey the Hospital`s thermal energy supply and demand systems to identify no-cost and low-cost measures that will reduce the Hospital`s energy requirements. Applicable measures would then be demonstrated in the Hospital through a partnership with US and Polish organizations and a sister hospital in the United States.

  4. adefovir-treated lamivudine-resistant chronic: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    pain of the lower back and neck. The focus of this work is on the multimodal input 37 Cough REVIEW Chronic cough hypersensitivity syndrome CiteSeer Summary: Chronic cough has...

  5. ANALYZING MUSCULAR PAIN AND THE EFFECTS OF EXERCISE ON CHRONIC PAIN

    E-Print Network [OSTI]

    Sharma, Neena

    2008-08-22T23:59:59.000Z

    Most people suffering from various chronic pain syndromes report deep tissue pain. However, our knowledge about chronic musculoskeletal pain is primarily based on rodent models of cutaneous pain. Little is known about ...

  6. Changes in Large Pulmonary Arterial Viscoelasticity in Chronic Pulmonary Hypertension

    E-Print Network [OSTI]

    Lakes, Roderic

    Changes in Large Pulmonary Arterial Viscoelasticity in Chronic Pulmonary Hypertension Zhijie Wang1 of pulmonary arterial hypertension (PAH) and is an excellent predictor of mortality due to right ventricular at a physiologically relevant frequency (10 Hz) in hypertensive PAs. The dynamic elastic modulus (E), a material

  7. Prevalence of Chronic Atrial Fibrillation in Dialysis Patients

    E-Print Network [OSTI]

    Wetmore, James B.

    2011-05-31T23:59:59.000Z

    .7) per 1000 patient-years. Age 60 years, male sex, Caucasian race, body mass index 30 kg/m2, and inability to ambulate were associated with chronic AF; hypertension as a comorbidity was inversely associated with AF. Occurrence of AF was roughly 10 times...

  8. ORIGINAL ARTICLE Acupuncture for Upper-Extremity Rehabilitation in Chronic

    E-Print Network [OSTI]

    Schaechter, Judith D.

    , and improvement trends in UE motor function (P .09) and digit ROM (P .06). Conclusions: Based on ITT analyses, we Sham-Controlled Study Peter M. Wayne, PhD, David E. Krebs, PhD, Eric A. Macklin, PhD, Rosa Schnyer, Lic. Acupuncture for upper- extremity rehabilitation in chronic stroke: a randomized sham- controlled study. Arch

  9. Activated ClpP kills persisters and eradicates a chronic biofilm infection.

    SciTech Connect (OSTI)

    Conlon, Brian P.; Nakayasu, Ernesto S.; Fleck, Laura E.; LaFleur, Michael D.; Isabella, Vincent M.; Coleman, K.; Leonard, Steve N.; Smith, Richard D.; Adkins, Joshua N.; Lewis, Kim

    2013-11-21T23:59:59.000Z

    The current antibiotic crisis stems from two distinct phenomena-drug resistance, and drug tolerance. Resistance mechanisms such as drug efflux or modification prevent antibiotics from binding to their targets 1, allowing pathogens to grow. Antibiotic tolerance is the property of persister cells, phenotypic variants of regular bacteria 2. Antibiotics kill by corrupting targets, but these are inactive in dormant persisters, leading to tolerance. Persisters were first identified by Joseph Bigger in 1944, when he discovered a surviving sub-population of Staphylococcus following treatment with penicillin3. Persisters are largely responsible for recalcitrance of chronic diseases such as tuberculosis, and various infections associated with biofilms - endocarditis, osteomyelitis, infections of catheters and indwelling devices, and deep-seated infections of soft tissues 4. There are a number of redundant pathways involved in persister formation5,6 precluding development of drugs inhibiting their formation. The acyldepsipeptide antibiotic (ADEP 4) has been shown to activate the ClpP protease resulting in death of growing cells 7. Here we show that ADEP4 activated ClpP becomes a fairly non-specific protease and kills persister cells by degradation of over 400 intracellular targets. clpP mutants are resistant to ADEP4 7, but we find that they display increased susceptibility to killing by a range of conventional antibiotics. Combining ADEP4 with rifampicin leads to eradication of persisters, stationary and biofilm populations of Staphylococcus aureus in vitro and in a deep-seated murine infection. Target corruption/activation provides an approach to killing persisters and eradicating chronic infections.

  10. Asbestos-related pulmonary disease in boilermakers

    SciTech Connect (OSTI)

    Demers, R.Y.; Neale, A.V.; Robins, T.; Herman, S.C. (Wayne State Univ., Detroit, MI (USA))

    1990-01-01T23:59:59.000Z

    Boilermakers are skilled building tradesmen who construct, repair, and dismantle boilers. The present study reports on the evaluation of members of a Michigan boilermaker's union for the presence of signs and symptoms of chronic pulmonary disease. Study variables included standardized evaluations of chest x-ray findings, pulmonary function testing, physical examination, and respiratory symptoms. An overall participation rate of 69% was achieved. A non-participant survey identified no significant differences between participants and non-participants in dyspnea, cough, age, or smoking history. Among participants with greater than 20 years experience in the trade, the mean FVC was 91% of predicted; the FEV1 was 86% of predicted; 25% showed at least a 1/0 profusion of interstitial markings on chest x-ray; 30% had bilateral pleural abnormalities; and 52% had audible inspiratory rales on physical examination. Forced vital capacity and forced expiratory volume at one second both decreased with years in the trade. Chest x-ray findings of interstitial fibrosis and pleural plaques were related to ten or more years in the trade, as were respiratory symptoms of pulmonary rales, wheeze, and dyspnea.

  11. arch jacob disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Chronicity: Major Findings Disparities, Health Disparities Loan Repayment Program. Project: "Chronic Homelessness, labor market Loudon, Catherine 10 Jacob Zilber Originally...

  12. Reproductive Diseases in Cattle

    E-Print Network [OSTI]

    Sprott, L. R.; Field, Bob

    1998-12-03T23:59:59.000Z

    susceptible. Droplets of urine from infected cows can infect normal cows after contact with the eye or mucous membranes of the nose or mouth. The disease infects more cattle each day, preventing cows from settling and lengthening their calving intervals... abortus) fetal membranes from aborting heifers at 4-12 not vaccinate bulls. cow; fetus; months. placenta Leptospirosis Bacterial (At least Urine of infected Any stage, Sample 10 Every 6 months Laboratory should deter- 5 serotypes) animals...

  13. Inherited risk for common disease

    E-Print Network [OSTI]

    Banava, Helen

    2007-01-01T23:59:59.000Z

    Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...

  14. Chobert MN et al LIVER PRECURSOR CELLS INCREASE HEPATIC FIBROSIS INDUCED BY CHRONIC

    E-Print Network [OSTI]

    Boyer, Edmond

    by chronic carbon tetrachloride (CCl4) administration for 6 weeks, in combination with chronic; CCl4, carbon tetrachloride; CK19, cytokeratin 19; CCR2, chemokine C-C motif receptor 2; EMTChobert MN et al LIVER PRECURSOR CELLS INCREASE HEPATIC FIBROSIS INDUCED BY CHRONIC CARBON

  15. HOSPITAL VENTILATION STANDARDS AND ENERGY CONSERVATION: A SUMMARY OF THE LITERATURE WITH CONCLUSIONS AND RECOMMENDATIONS, FY 78 FINAL REPORT

    E-Print Network [OSTI]

    DeRoos, R.L.

    2011-01-01T23:59:59.000Z

    on the premise that current hospital ventilation standardsand ,ventilation rates based on the premise of reducing

  16. The Economy of Internet-Based Hospitality Exchange

    E-Print Network [OSTI]

    Tagiew, Rustam

    2015-01-01T23:59:59.000Z

    In this paper, we analyze and compare general development and individual behavior on two non-profit internet-based hospitality exchange services -- bewelcome.org and warmshowers.org. We measure the effort needed to achieve a real-life interaction, whereby the advantages of mutual altruism arise. The effort needed is the communication quantified in units of time. Since the amount of effort is not obvious to individual users, the development of the effort investing strategy is investigated. The impact of individual behavior on general development is discussed.

  17. Designing for Energy Conservation - The Cypress Fairbanks Medical Center Hospital

    E-Print Network [OSTI]

    Wiernik, L. B.; Ranzau, P. A.

    1984-01-01T23:59:59.000Z

    ,000 'quare foot is heat gain. The longest dbeneions of the Cypress cmprised Of three 40-bed medical'sur&ical In-patient Medical Center are oriented northwest and southeast. care nureing floors, and the first floor which houses All of the external windows... are 1/4" solar bronze administrative, business, dienostic, treatment and and internally ehded by 3" wide vertical blinds. ancillary services. The hospital is adjoined by a First floor windows are ehaded by a -$-foot overhang. 40,000 square foot med...

  18. The association between depressive symptoms in the community, non-psychiatric hospital admission and hospital outcomes: a systematic review.

    E-Print Network [OSTI]

    Prina, A. Matthew; Cosco, Theodore D.; Dening, Tom; Beekman, Aartjan; Brayne, Carol; Huisman, Martijn

    2014-11-08T23:59:59.000Z

    E, Pagano F, Pozzi G, Bernabei R, Zuccala G. Depressive symptoms are associated with hospitalization, but not with mortality in the elderly: a population-based study. Aging Ment Health 2010;14:955–61. [24] Rowan PJ, Davidson K, Campbell JA, Dobrez DG... - sequent use of health and social services. Arch Gerontol Geriatr 2006;42: 125–39. [29] Brown JS, Boardman J, Whittinger N, Ashworth M. Can a self-referral system help improve access to psychological treatments? Br J Gen Pract 2010;60:365–71. [30] Wong SY...

  19. Large Hospital 50% Energy Savings: Technical Support Document

    SciTech Connect (OSTI)

    Bonnema, E.; Studer, D.; Parker, A.; Pless, S.; Torcellini, P.

    2010-09-01T23:59:59.000Z

    This Technical Support Document documents the technical analysis and design guidance for large hospitals to achieve whole-building energy savings of at least 50% over ANSI/ASHRAE/IESNA Standard 90.1-2004 and represents a step toward determining how to provide design guidance for aggressive energy savings targets. This report documents the modeling methods used to demonstrate that the design recommendations meet or exceed the 50% goal. EnergyPlus was used to model the predicted energy performance of the baseline and low-energy buildings to verify that 50% energy savings are achievable. Percent energy savings are based on a nominal minimally code-compliant building and whole-building, net site energy use intensity. The report defines architectural-program characteristics for typical large hospitals, thereby defining a prototype model; creates baseline energy models for each climate zone that are elaborations of the prototype models and are minimally compliant with Standard 90.1-2004; creates a list of energy design measures that can be applied to the prototype model to create low-energy models; uses industry feedback to strengthen inputs for baseline energy models and energy design measures; and simulates low-energy models for each climate zone to show that when the energy design measures are applied to the prototype model, 50% energy savings (or more) are achieved.

  20. Spread of pathogens in the patient transfer network of US hospitals

    E-Print Network [OSTI]

    Gracia, Juan Fernández; Barnett, Michael L; Eguíluz, Víctor M; Christakis, Nicholas A

    2015-01-01T23:59:59.000Z

    Emergent antibiotic-resistant bacterial infections are an increasingly significant source of morbidity and mortality. Antibiotic-resistant organisms have a natural reservoir in hospitals, and recent estimates suggest that almost 2 million people develop hospital-acquired infections each year in the US alone. We investigate a network induced by the transfer of Medicare patients across US hospitals over a 2-year period to learn about the possible role of hospital-to-hospital transfers of patients in the spread of infections. We analyze temporal, geographical, and topological properties of the transfer network and demonstrate, using C. Diff. as a case study, that this network may serve as a substrate for the spread of infections. Finally, we study different strategies for the early detection of incipient epidemics, finding that using approximately 2% of hospitals as sensors, chosen based on their network in-degree, results in optimal performance for this early warning system, enabling the early detection of 80% ...

  1. New therapeutic aspect for carvedilol: Antifibrotic effects of carvedilol in chronic carbon tetrachloride-induced liver damage

    SciTech Connect (OSTI)

    Hamdy, Nadia [Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)] [Department of Biochemistry, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt); El-Demerdash, Ebtehal, E-mail: ebtehal_dm@yahoo.com [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)] [Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo (Egypt)

    2012-06-15T23:59:59.000Z

    Portal hypertension is a common complication of chronic liver diseases associated with liver fibrosis and cirrhosis. At present, beta-blockers such as carvedilol remain the medical treatment of choice for protection against variceal bleeding and other complications. Since carvedilol has powerful antioxidant properties we assessed the potential antifibrotic effects of carvedilol and the underlying mechanisms that may add further benefits for its clinical usefulness using a chronic model of carbon tetrachloride (CCl4)-induced hepatotoxicity. Two weeks after CCl4 induction of chronic hepatotoxicity, rats were co-treated with carvedilol (10 mg/kg, orally) daily for 6 weeks. It was found that treatment of animals with carvedilol significantly counteracted the changes in liver function and histopathological lesions induced by CCl4. Also, carvedilol significantly counteracted lipid peroxidation, GSH depletion, and reduction in antioxidant enzyme activities; glutathione-S-transferase and catalase that was induced by CCl4. In addition, carvedilol ameliorated the inflammation induced by CCl4 as indicated by reducing the serum level of acute phase protein marker; alpha-2-macroglobulin and the liver expression of nuclear factor-kappa B (NF-?B). Finally, carvedilol significantly reduced liver fibrosis markers including hydroxyproline, collagen accumulation, and the expression of the hepatic stellate cell (HSC) activation marker; alpha smooth muscle actin. In conclusion, the present study provides evidences for the promising antifibrotic effects of carvedilol that can be explained by amelioration of oxidative stress through mainly, replenishment of GSH, restoration of antioxidant enzyme activities and reduction of lipid peroxides as well as amelioration of inflammation and fibrosis by decreasing collagen accumulation, acute phase protein level, NF-?B expression and finally HSC activation. -- Highlights: ? Carvedilol is a beta blocker with antioxidant and antifibrotic properties. ? It restores GSH and antioxidant enzyme activities and reduces lipid peroxidation. ? It ameliorates inflammation and nuclear factor kappa-B expression. ? It ameliorates fibrosis by decreasing collagen accumulation and HSC activation.

  2. active chronic lymphocytic: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cause diseases with long incubation periods, insidious onsets, and slowly progressive courses (1). The members of the virus group include visna virus of sheep, caprine...

  3. Demonstration of Advanced Technologies for Multi-Load Washers in Hospitality and Healthcare – Wastewater Recycling Technology

    SciTech Connect (OSTI)

    Boyd, Brian K.; Parker, Graham B.; Petersen, Joseph M.; Sullivan, Greg; Goetzler, W.; Foley, K. J.; Sutherland, T. A.

    2014-08-14T23:59:59.000Z

    The objective of this demonstration project was to evaluate market-ready retrofit technologies for reducing the energy and water use of multi-load washers in healthcare and hospitality facilities. Specifically, this project evaluated laundry wastewater recycling technology in the hospitality sector and ozone laundry technology in both the healthcare and hospitality sectors. This report documents the demonstration of a wastewater recycling system installed in the Grand Hyatt Seattle.

  4. Development of Graves' disease following radiation therapy in Hodgkin's disease

    SciTech Connect (OSTI)

    Loeffler, J.S.; Tarbell, N.J.; Garber, J.R.; Mauch, P.

    1988-01-01T23:59:59.000Z

    Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population.

  5. Sulfur dioxide-induced chronic bronchitis in beagle dogs

    SciTech Connect (OSTI)

    Greene, S.A.; Wolff, R.K.; Hahn, F.F.; Henderson, R.F.; Mauderly, J.L.; Lundgren, D.L.

    1984-01-01T23:59:59.000Z

    This study was done to produce a model of chronic bronchitis. Twelve beagle dogs were exposed to 500 ppm sulfur dioxide (SO/sub 2/) for 2 h/d, 5d/wk for 21 wk and 4 dogs were sham-exposed to filtered ambient air for the same period. Exposure effects were evaluated by periodically examining the dogs using chest radiographs, pulmonary function, tracheal mucous clearance, and the cellular and soluble components of bronchopulmonary lavage fluids. Dogs were serially sacrificed after 13 and 21 wk of exposure and after 6 and 14 wk of recovery. Clinical signs produced in the SO/sub 2/-exposed dogs included mucoid nasal discharge, productive cough, moist rales on auscultation, tonsilitis, and conjunctivitis. Chest radiographs revealed mild peribronchiolar thickening. Histopathology, tracheal mucous clearance measurements, and lavage cytology were consistent with a diagnosis of chronic bronchitis. It is concluded that repeated exposure to 500 ppm SO/sub 2/ for 21 wk produced chronic bronchitis in the beagle dog. Complete recovery occurred within 5 wk following cessation of SO/sub 2/ exposure. 43 references, 2 figures, 2 tables.

  6. ORISE: WeB-MEDIS System Allows Hospitals to Gather and Track...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    WeB-MEDIS ORISE-developed system helps emergency responders and hospitals gather and track patient data during emergencies The Oak Ridge Institute for Science and Education...

  7. Rebuilding it Better: Greensburg, Kansas, Kiowa County Memorial Hospital (Brochure) (Revised)

    Office of Energy Efficiency and Renewable Energy (EERE)

    This brochure details the sustainable and green aspects of the LEED Platinum-designed Kiowa County Memorial Hospital in Greensburg, Kansas.

  8. E-Print Network 3.0 - adolescent hospitalized Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    FELLOW POSITION Department of Psychiatry Summary: at the Child and Adolescent Mental Health Care Program at Children's Hospital and will have desk space... POSTDOCTORAL FELLOW...

  9. E-Print Network 3.0 - academic hospital perspective Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Vietnamese hospitals operate and put spotlight on input savings. Since the demand for health care is large Source: Feigon, Brooke - School of Mathematics, University of East...

  10. E-Print Network 3.0 - analysis reduces hospital Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    29 ECPR General Conference, Potsdam, 10-12 September 2009 Panel: Rescaling Health Care Policy Summary: of influence in the hospital reform of post-soviet countries through...

  11. E-Print Network 3.0 - abdulaziz university hospital Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    hospitals operate and put spotlight on input savings. Since the demand for health care is large Source: Feigon, Brooke - School of Mathematics, University of East...

  12. E-Print Network 3.0 - aphm university hospital Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    hospitals operate and put spotlight on input savings. Since the demand for health care is large Source: Feigon, Brooke - School of Mathematics, University of East...

  13. E-Print Network 3.0 - ajou university hospital Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    hospitals operate and put spotlight on input savings. Since the demand for health care is large Source: Feigon, Brooke - School of Mathematics, University of East...

  14. Overview of the Consortium of Hospitals Advancing Research on Tobacco (CHART)

    E-Print Network [OSTI]

    Riley, William T; Stevens, Victor J; Zhu, Shu-Hong; Morgan, Glen; Grossman, Debra

    2012-01-01T23:59:59.000Z

    Zhu protocol uses a factorial design to test the effects ofJolla hospital (five) 2 x 2 factorial design comparing post-

  15. A Manual of Poultry Diseases.

    E-Print Network [OSTI]

    Bell, R. R.; Flowers, A. I.; Grumbles, L. C.; Meinecke, C. F.; Patterson, C. M.; Wormell, B. C.; Hall, C. F.

    1965-01-01T23:59:59.000Z

    " of ocular leucosis is specific. Hatchery and Breeder Flock Health Management Sanitation is a much used, but poorly defined word. The usual implication is that sanitation is a universally understood practice that may be applied to prevent all diseases... must be based on the nature of specific diseases. The ;kmbiguity surrounding the term "sanitation" can be avoided by using a term "management and sanitation for disease prevention." This phrase then would be defined as all practices, specific...

  16. Using Wikipedia to forecast diseases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    said. "In the same way we check the weather each morning, individuals and public health officials can monitor disease incidence and plan for the future based on today's...

  17. Contrast Set Mining for Distinguishing between Similar Diseases

    E-Print Network [OSTI]

    Novak, Petra Kralj

    , 10000 Zagreb, Croatia 4 University Hospital of Traumatology, Draskovi´ceva 19, 10000 Zagreb, Croatia

  18. Students in Health Sciences at the UA simulate real hospital practice with the latest technological devices

    E-Print Network [OSTI]

    Escolano, Francisco

    , as well as maternal and child care. It is equipped with hospital beds, incubators, medical simulationStudents in Health Sciences at the UA simulate real hospital practice with the latest technological that will allow students to complete their practical training with the latest technological devices. The opening

  19. INDIAN INSTITUTE OF TECHNOLOGY KANPUR FORM FOR REIMBURSEMENT OF HOSPITALIZATION CHARGES

    E-Print Network [OSTI]

    Srivastava, Kumar Vaibhav

    . Place at which the patient availed hospitalization facility 8. Details of the amount claimed I. Medical Attendance (i) Charges for Pathological, Bacteriological, Radiological or other similar tests undertaken, Bacteriological, Radiological or other similar tests indicating: (a) The name of the hospital or laboratory

  20. CLINICAL VOLUNTEER PROGRAMS Children's Hospital of Orange County/ commitment = 100 hours

    E-Print Network [OSTI]

    Barrett, Jeffrey A.

    CLINICAL VOLUNTEER PROGRAMS Children's Hospital of Orange County/ commitment = 100 hours 455 S Hospital Clinical Care Extender Program/ACCEPTING APPLICATIONS NOW INTERVIEWING THROUGH MARCH 26TH 1 Hoag-4 departments Telephone 949 764-5740 Applications every three months http://www.hoag.org/volunteering/clinical

  1. DOES HOSPITAL COMPETITION SAVE LIVES? EVIDENCE FROM THE ENGLISH NHS PATIENT CHOICE REFORMS*

    E-Print Network [OSTI]

    Mateo, Jill M.

    DOES HOSPITAL COMPETITION SAVE LIVES? EVIDENCE FROM THE ENGLISH NHS PATIENT CHOICE REFORMS* Zack Cooper, Stephen Gibbons, Simon Jones and Alistair McGuire Recent substantive reforms to the English with fixed prices. This study investigates whether these reforms led to improvements in hospital quality. We

  2. Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease

    SciTech Connect (OSTI)

    Wu, Weibin [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China) [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China); Institutes of Biomedical Science, Fudan University, Shanghai 200032 (China); Zhu, Bo; Peng, Xiaomin [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China)] [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China); Zhou, Meiling, E-mail: meilingzhou2012@gmail.com [Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032 (China)] [Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032 (China); Jia, Dongwei, E-mail: jiadongwei@fudan.edu.cn [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China)] [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China); Gu, Jianxin [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China) [Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032 (China); Institutes of Biomedical Science, Fudan University, Shanghai 200032 (China)

    2014-01-03T23:59:59.000Z

    Highlights: •FXR activity was impaired by chronic ethanol ingestion in a murine model of ALD. •Activation of FXR attenuated alcohol-induced liver injury and steatosis. •Activation of FXR attenuated cholestasis and oxidative stress in mouse liver. -- Abstract: Alcoholic liver disease (ALD) is a common cause of advanced liver disease, and considered as a major risk factor of morbidity and mortality worldwide. Hepatic cholestasis is a pathophysiological feature observed in all stages of ALD. The farnesoid X receptor (FXR) is a member of the nuclear hormone receptor superfamily, and plays an essential role in the regulation of bile acid, lipid and glucose homeostasis. However, the role of FXR in the pathogenesis and progression of ALD remains largely unknown. Mice were fed Lieber-DeCarli ethanol diet or an isocaloric control diet. We used a specific agonist of FXR WAY-362450 to study the effect of pharmacological activation of FXR in alcoholic liver disease. In this study, we demonstrated that FXR activity was impaired by chronic ethanol ingestion in a murine model of ALD. Activation of FXR by specific agonist WAY-362450 protected mice from the development of ALD. We also found that WAY-362450 treatment rescued FXR activity, suppressed ethanol-induced Cyp2e1 up-regulation and attenuated oxidative stress in liver. Our results highlight a key role of FXR in the modulation of ALD development, and propose specific FXR agonists for the treatment of ALD patients.

  3. Technical Support Document: Development of the Advanced Energy Design Guide for Large Hospitals - 50% Energy Savings

    SciTech Connect (OSTI)

    Bonnema, E.; Leach, M.; Pless, S.

    2013-06-01T23:59:59.000Z

    This Technical Support Document describes the process and methodology for the development of the Advanced Energy Design Guide for Large Hospitals: Achieving 50% Energy Savings Toward a Net Zero Energy Building (AEDG-LH) ASHRAE et al. (2011b). The AEDG-LH is intended to provide recommendations for achieving 50% whole-building energy savings in large hospitals over levels achieved by following Standard 90.1-2004. The AEDG-LH was created for a 'standard' mid- to large-size hospital, typically at least 100,000 ft2, but the strategies apply to all sizes and classifications of new construction hospital buildings. Its primary focus is new construction, but recommendations may be applicable to facilities undergoing total renovation, and in part to many other hospital renovation, addition, remodeling, and modernization projects (including changes to one or more systems in existing buildings).

  4. MFR PAPER 1300 Shellfish Diseases

    E-Print Network [OSTI]

    promise for the efficient recycling of organic waste materials, such as agricultural wastes, and metazoan parasitic and infectious agents. In addition, predators, toxic agents, and fouling organisms studied. DISEASES OF SHELLFISH A list of organisms that cause com- mon diseases in oysters is shown

  5. aav-mediated chronic over-expression: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    obstructive uropathy.Autonomic neuropathy is well associated with chronic renal failure patients. Knowledge of autonomic dysfunction canencourage patients and physicians to...

  6. australian chronically-ill adults: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with a chronic illness, they eventually undergo the transition from paediatric health care to adult health care. This transition typically occurs simultaneously with other...

  7. Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    between fibrinogen and air pollution in these data. In ourbetween particulate air pollution and cardiovascular diseasebetween ambient air pollution and markers of inflammation

  8. Examining Public Health System Responses to the Chronic Diseases of HIV/AIDS and Diabetes: Experiences from Mexico and Brazil

    E-Print Network [OSTI]

    Gidi, Virginia Eve

    2010-01-01T23:59:59.000Z

    A. Cohn, Health reform in Brazil: lessons to consider. Am JPetersen, M.L. , et al. , Brazil, in The HIV Pandemic: localof the AIDS epidemic in Brazil: principal epidemiological

  9. Examining Public Health System Responses to the Chronic Diseases of HIV/AIDS and Diabetes: Experiences from Mexico and Brazil

    E-Print Network [OSTI]

    Gidi, Virginia Eve

    2010-01-01T23:59:59.000Z

    da Saude: Brasilia. Ministerio da Saúde do Brasil,Saude Brasil 2008: 20 anos de sistemaunico de saude (SUS) no Brasil, Secretaria de Vigiliancia en

  10. Effect of matrix stiffness on the behaviour of liver resident cell populations in chronic liver disease and hepatocarcinogenesis 

    E-Print Network [OSTI]

    Gordon-Walker, Timothy Thomas; Walker, Timothy Thomas Gordon

    2014-07-05T23:59:59.000Z

    Introduction: The development of liver fibrosis is characterised by dramatic changes in the biomechanical composition and mechanical properties of the extracellular matrix (ECM). Increases in matrix stiffness associated ...

  11. Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    Short-term effects of air pollution: a panel study of bloodindicates that ambient air pollution is associated withto daily changes in air pollution in Erfurt, Germany. 12

  12. Office of Enterprise Assessments Follow-up Review of the Hanford Site Chronic Beryllium Disease Prevention Program - June 2015

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2:Introduction toManagementOPAM PolicyOf Environmental ManagementRollout -Summary

  13. Examining Public Health System Responses to the Chronic Diseases of HIV/AIDS and Diabetes: Experiences from Mexico and Brazil

    E-Print Network [OSTI]

    Gidi, Virginia Eve

    2010-01-01T23:59:59.000Z

    generations of reform in Mexico. Lancet, 2003. 362(9396): p.Carillo, and J.J. García, Mexico, in World Health Systems:Secretaria de Salud de Mexico and et al, Numeralia 2008:

  14. Clinical Presentation of Patients Diagnosed Post-Operatively with Appendicitis at Private Hospitals in Southern Puerto Rico

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    Hospitals in Southern Puerto Rico Carlos Garcia-Gubern, MD;Luke’s Episcopal Hospital, Ponce, Puerto Rico; Ponce Schoolof Medicine, Ponce, Puerto Rico Objective: The goal of our

  15. Supply chain automation and the effects on clinician satisfaction and patient care quality in the hospital setting

    E-Print Network [OSTI]

    Xie, Yue, M. Eng. Massachusetts Institute of Technology

    2006-01-01T23:59:59.000Z

    The healthcare industry, more specifically hospitals, has in recent times been experiencing a steady rise in nursing shortages and cost pressures. To offset these problems hospitals have increasingly relied upon supply ...

  16. Early detection of contagious diseases

    DOE Patents [OSTI]

    Colston, Jr., Billy W. (San Ramon, CA); Milanovich, Fred P. (Lafayette, CA); Estacio, Pedro (Mission San Jose, CA); Chang, John (Walnut Creek, CA)

    2011-08-09T23:59:59.000Z

    This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

  17. Lessons from a rare disease

    E-Print Network [OSTI]

    Dutchen, Stephanie Lynn

    2009-01-01T23:59:59.000Z

    Progeria is a genetic aging disease of childhood affecting an estimated one in four to eight million births. Children with progeria experience a range of developmental disorders and aging-like symptoms, including wrinkled ...

  18. Causal Inference and Prediction in Health Studies: Environmental Exposures and Schistosomiasis, HIV-1 Genotypic Susceptibility Scores and Virologic Suppression, and Risk of Hospital Readmission for Heart Failure Patients

    E-Print Network [OSTI]

    Sudat, Sylvia

    2012-01-01T23:59:59.000Z

    hospitalization for congestive heart failure among Medicarepredictors of readmission for heart failure: a systematicof hospital readmission for heart failure: development of a

  19. A Manual of Poultry Diseases.

    E-Print Network [OSTI]

    Hall, C. F.; Bell, R. R.; Clifford, R. L., Jr.; Glass, S. E.; Grimes, J. E.; Grumbles, L. C.; Keahey, E. E.; Wormell, B. C.

    1971-01-01T23:59:59.000Z

    surrounding the term "sanitation" can be avoided by using the expression "management and sanitation for disease preven- , tion." This phrase then would be defined as all practices, specific and nonspecific, that the poultry- man applies to ptevent.... Change litter and thoroughly clean and disinfect the house and equipment between each group of birds. While litter selection and management is a large subject, applying this recommendation as a general practice will prevent many disease and parasite...

  20. Intoxication aigu et chronique au cadmium Acute and chronic cadmium poisoning

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Intoxication aiguë et chronique au cadmium Acute and chronic cadmium poisoning Pascal ANDUJAR1 poisoning Summary (176 words): Key words : cadmium - poisoning - pneumonia - nephropathy - osteomalacia or chemical pneumonitis. Cadmium chronic poisoning causes mainly renal tubulopathy and could be the cause

  1. Age, gender, and breed as risk factors for acute and chronic equine laminitis

    E-Print Network [OSTI]

    Alford, Patricia Lee

    1999-01-01T23:59:59.000Z

    , and time of diagnosis. The 90% of case-control pairs (78 acute, 155 chronic) having complete data for age, gender, and breed were used in separate conditional logistic recession models for acute and chronic laminitis. The odds ratio was calculated...

  2. Lab Invest . Author manuscript Liver precursor cells increase hepatic fibrosis induced by chronic carbon

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    by chronic carbon tetrachloride intoxication in rats Marie-No le Chobertë 1 # , Dominique Couchie 1 # , Agn, Myelomonocytic ; analysis ; Carbon Tetrachloride ; toxicity ; Epithelial-Mesenchymal Transition ; Keratin-19 of LPC, using a new experimental model in which rat liver fibrosis was induced by chronic carbon

  3. Eur Heart J . Author manuscript Chronic heart rate reduction with ivabradine improves systolic function of

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Eur Heart J . Author manuscript Page /1 11 Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct mechanical effect the adaptations of left ventricular function and calcium handling to chronic heart rate reduction with ivabradine

  4. A Century of Progress: Milestones in Sickle Cell Disease

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Disease? Sickle cell disease, also known as sickle cell anemia, is inherited. People who have the disease

  5. Imaging Lung Disease in Systemic Sclerosis

    E-Print Network [OSTI]

    Strollo, Diane; Goldin, Jonathan

    2010-01-01T23:59:59.000Z

    W, et al. : Interstitial lung disease in progressiveGL, Myers JL: Diffuse lung disease: diagnostic accuracy ofsurgical biopsy of the lung. Radiology 1997, 205:229–234.

  6. Repetitive Pediatric Anesthesia in a Non-Hospital Setting

    SciTech Connect (OSTI)

    Buchsbaum, Jeffrey C., E-mail: jbuchsba@iupui.edu [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana (United States); Indiana University Health Proton Therapy Center, Bloomington, Indiana (United States); McMullen, Kevin P.; Douglas, James G. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana (United States) [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana (United States); Indiana University Health Proton Therapy Center, Bloomington, Indiana (United States); Jackson, Jeffrey L.; Simoneaux, R. Victor; Hines, Matthew; Bratton, Jennifer; Kerstiens, John [Indiana University Health Proton Therapy Center, Bloomington, Indiana (United States)] [Indiana University Health Proton Therapy Center, Bloomington, Indiana (United States); Johnstone, Peter A.S. [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana (United States) [Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana (United States); Indiana University Health Proton Therapy Center, Bloomington, Indiana (United States)

    2013-04-01T23:59:59.000Z

    Purpose: Repetitive sedation/anesthesia (S/A) for children receiving fractionated radiation therapy requires induction and recovery daily for several weeks. In the vast majority of cases, this is accomplished in an academic center with direct access to pediatric faculty and facilities in case of an emergency. Proton radiation therapy centers are more frequently free-standing facilities at some distance from specialized pediatric care. This poses a potential dilemma in the case of children requiring anesthesia. Methods and Materials: The records of the Indiana University Health Proton Therapy Center were reviewed for patients requiring anesthesia during proton beam therapy (PBT) between June 1, 2008, and April 12, 2012. Results: A total of 138 children received daily anesthesia during this period. A median of 30 fractions (range, 1-49) was delivered over a median of 43 days (range, 1-74) for a total of 4045 sedation/anesthesia procedures. Three events (0.0074%) occurred, 1 fall from a gurney during anesthesia recovery and 2 aspiration events requiring emergency department evaluation. All 3 children did well. One aspiration patient needed admission to the hospital and mechanical ventilation support. The other patient returned the next day for treatment without issue. The patient who fell was not injured. No patient required cessation of therapy. Conclusions: This is the largest reported series of repetitive pediatric anesthesia in radiation therapy, and the only available data from the proton environment. Strict adherence to rigorous protocols and a well-trained team can safely deliver daily sedation/anesthesia in free-standing proton centers.

  7. A Novel Flexible Sinusoidal Probe for Chronic Extracellular Brain Recording

    E-Print Network [OSTI]

    Sohal, Harbaljit S; Jackson, Andrew; Baker, Stuart N; O'Neill, Anthony

    2015-01-01T23:59:59.000Z

    Current microelectrodes designed to record chronic neural activity suffer from recording instabilities due to the modulus mismatch between the electrode materials and the brain. We sought to address this by microfabricating a novel flexible neural probe. Our probe was fabricated from parylene-C with a WTi metal, using contact photolithography and reactive ion etching, with three design features to address this modulus mismatch: a sinusoidal shaft, a rounded tip and a polyimide anchoring ball. The anchor restricts movement of the electrode recording sites and the shaft accommodates the brain motion. We successfully patterned thick metal and parylene-C layers, with a reliable device release process leading to high functional yield and were able to sample stable neural activity for over 2 years with this probe. We have successfully optimized the fabrication process to produce a reliable probe with high functional yield. This novel reliably microfabricated probe can record stable neural activity for up to two yea...

  8. Managing variability to improve quality, capacity and cost in the perioperative process at Massachusetts General Hospital

    E-Print Network [OSTI]

    Price, Devon J. (Devon Jameson)

    2011-01-01T23:59:59.000Z

    The widely held assumption is that to improve access and quality of health care, we need to spend more. In fact, that is not necessarily true. The results of this project, performed at Massachusetts General Hospital (MGH), ...

  9. Ecological theory suggests that antimicrobial cycling will not reduce antimicrobial resistance in hospitals

    E-Print Network [OSTI]

    Bergstrom, Carl T.

    in hospitals Carl T. Bergstrom* , Monique Lo , and Marc Lipsitch *Department of Biology, University success reported thus far from clinical trials of antimicrobial cycling. Nosocomial infection is a major

  10. THE IMPACT OF WORK UNIT AND ORGANIZATION SUPPORT ON HOSPITAL PATIENT SAFETY

    E-Print Network [OSTI]

    Kemper, Carol Ann

    2009-01-27T23:59:59.000Z

    Based on the construct of a culture of safety, the study purpose was to discern the relationships between Organization Support (OS) and Work Unit Support (WS) on Hospital Patient Safety. OS and WS were operationalized ...

  11. NREL Technical Reports Guide the Way to 50% Energy Savings in Hospitals, Office Buildings (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2011-02-01T23:59:59.000Z

    Researchers at the National Renewable Energy Laboratory (NREL) have developed two technical reports that provide recommendations to help designers and operators of large office buildings and hospitals achieve at least a 50% energy savings using existing technology.

  12. Continuous Commissioning of the Reynolds Army Community Hospital, Fort Sill, Oklahoma

    E-Print Network [OSTI]

    Turner, W. D.; Baltazar-Cervantes, J. C.; Martinez, J. T.

    2007-01-01T23:59:59.000Z

    Continuous Commissioning® (CC®) of the Reynolds Army Community Hospital facility was a two phase project. The first phase consisted of a point-to-point verification of a newly upgraded Energy Management Control System (EMCS) and calibration of key...

  13. Enthalpy Wheels Come of Age: Applying Energy Recovery Ventilation to Hospitality Venues in Hot, Humid Climate

    E-Print Network [OSTI]

    Wellford, B. W.

    2000-01-01T23:59:59.000Z

    ventilation to hospitality venues in hot, humid climates need not be complex. This paper proposes guidelines that can facilitate application of the technology by specifiers or other construction professionals. These guidelines address evaluation of typical...

  14. Atendimento O cenrio o Setor de Radiologia do Hospital Universitrio da UFSC. Uma das salas

    E-Print Network [OSTI]

    Floeter, Sergio Ricardo

    Atendimento humanizado #12;O cenário é o Setor de Radiologia do Hospital Universitário da UFSC. Uma à mostra. O alvará sanitário do Serviço de Radiologia, revela o documento fixado na parede, teve

  15. In sickness and in wealth : hospitals, community benefits, and the Affordable Care Act

    E-Print Network [OSTI]

    Mella, Katherine M. (Katherine Manuela)

    2014-01-01T23:59:59.000Z

    The new community benefit guidelines for non-profit hospitals enacted by the 2010 Patient Protection and Affordable Care Act (ACA) present major opportunities for the public health and planning fields alike. Given that ...

  16. Energy Conservation Recommendations, Implementation Costs, and Projected Paybacks for Georgia's Targeted Schools and Hospitals Conservation Program

    E-Print Network [OSTI]

    Brown, M. L.; Moore, D. M.

    1988-01-01T23:59:59.000Z

    During the past year the Georgia Tech Research Institute performed technical assistance studies on over 100 school and hospital buildings under a program funded by the Governor's Office of Energy Resources. This program is known as the Targeted...

  17. A plan for Metropolitan State Hospital : imagery as a therapy for an institution

    E-Print Network [OSTI]

    McMurrin, Sterling James

    1988-01-01T23:59:59.000Z

    This thesis is both text and illustration to describe the process of transforming a state mental institution from an outdated, outmoded, conventional hospital into a living community. The goal of the project is to develop ...

  18. Nonprofit Hospitals’ Approach to Community Health Needs Assessment: A Mixed Methods Study

    E-Print Network [OSTI]

    Pennel, Cara LeAnne

    2014-07-15T23:59:59.000Z

    Nonprofit hospitals are tax exempt but must demonstrate community benefit to the Internal Revenue Service (IRS) to maintain this status. In attempts to improve accountability, the Patient Protection and Affordable Care Act of 2010 includes a...

  19. A CENSUS OF LONG STAY PATIENTS IN GOVERNMENT MENTAL HOSPITALS IN INDIA

    E-Print Network [OSTI]

    M. Venkataswamy Reddy

    A single day census found that long-stay patients (LSP) numbering 7,307 accounted for about 48 % of the total inpatient strength of 15,345 in government mental hospitals in India. A load of 2695 (37%) LSP were in two to five years duration of stay, 2782 (38%) were in five to fifteen years duration of stay, and the remaining 1830 (25%) were staying for more than fifteen years. About 11 % of LSP were aged sixty years and above, majority (53%) were males, non-voluntary cases constituted 80%. and more than two-thirds (69%) were schizophrenics. The characteristics distributions associated with high rates of LSP at individual hospitals were identified. The load of LSP was decreased by 9 % during the period from 1993 to 1999. Key words: Census, long-stay patients, government mental hospitals, national indicators Sufficient data on long-stay patients (LSP) in government mental hospitals were lacking in India, though certain informations about some individual hospitals or a small group of hospitals have been reported (Sathyavathi and

  20. Heart Disease and Early Heart Attack Care

    E-Print Network [OSTI]

    Ohta, Shigemi

    Heart Disease and Early Heart Attack Care Pamela Kostic, RN, CCCC, Chest Pain Coordinator, Stony Risk Factors · EHAC & Prevention #12;Heart disease includes a number of problems affecting the heart and the blood vessels in the heart. #12;Types of heart disease include: · Coronary artery disease (CAD) · Angina

  1. Radiologic atlas of rheumatic diseases

    SciTech Connect (OSTI)

    Dihlmann, W.

    1986-01-01T23:59:59.000Z

    This book is an ''atlas of rheumatic joint disease'' selected from 20 years of personal experience by the author. The author sets a goal of demonstrating the value of soft-tissue imaging in the diagnosis of early joint disease. This goal is achieved with high quality reproductions, many of which are presented in duplicate to illustrate bone and soft-tissue changes. The contents include an introductory overview of the ''Mosaic of Arthritis'' followed by sections on adult rheumatoid arthritis, seronegative spondyloarthropathies, classic collagen disease, enthesiopathies, and lastly a section on gout and psuedogout. The subject index is specific and indexes figures with boldface type. Each section is introduced by a brief outline or overview of the radiographic spectrum of the joint disorder to be illustrated.

  2. Mechanical Recanalization of Subacute Vessel Occlusion in Peripheral Arterial Disease with a Directional Atherectomy Catheter

    SciTech Connect (OSTI)

    Massmann, Alexander, E-mail: Alexander.Massmann@uks.eu; Katoh, Marcus [Saarland University Hospital, Department of Diagnostic and Interventional Radiology (Germany); Shayesteh-Kheslat, Roushanak [Saarland University Hospital, Department of General Surgery, Visceral, Vascular, and Pediatric Surgery (Germany); Buecker, Arno [Saarland University Hospital, Department of Diagnostic and Interventional Radiology (Germany)

    2012-10-15T23:59:59.000Z

    Purpose: To retrospectively examine the technical feasibility and safety of directional atherectomy for treatment of subacute infrainguinal arterial vessel occlusions. Methods: Five patients (one woman, four men, age range 51-81 years) with peripheral arterial disease who experienced sudden worsening of their peripheral arterial disease-related symptoms during the last 2-6 weeks underwent digital subtraction angiography, which revealed vessel occlusion in native popliteal artery (n = 4) and in-stent occlusion of the superficial femoral artery (n = 1). Subsequently, all patients were treated by atherectomy with the SilverHawk (ev3 Endovascular, USA) device. Results: The mean diameter of treated vessels was 5.1 {+-} 1.0 mm. The length of the occlusion ranged 2-14 cm. The primary technical success rate was 100%. One patient experienced a reocclusion during hospitalization due to heparin-induced thrombocytopenia. There were no further periprocedural complications, in particular no peripheral embolizations, until hospital discharge or during the follow-up period of 1 year. Conclusion: The recanalization of infrainguinal arterial vessel occlusions by atherectomy with the SilverHawk device is technically feasible and safe. In our limited retrospective study, it was associated with a high technical success rate and a low procedure-related complication rate.

  3. Easy Gardening.....Disease Control 

    E-Print Network [OSTI]

    Johnson, Jerral; Johnson, Jerral

    2009-05-29T23:59:59.000Z

    on plant roots and cause stunted plants. The most damaging nematode in the home garden is root knot. It causes galls or knots on susceptible plants such as toma- A good home gardener recognizes the symptoms of plant diseases quickly and takes steps...

  4. Environmental Contributions to Allergic Disease

    E-Print Network [OSTI]

    Levetin, Estelle

    with increased exposure to air pollution and indoor contaminants such as house dust mites, cockroaches linked to the severity of allergic disease. The contribution of house dust mites, cockroaches, animal some of the strongest evidence sug- gests a compelling link between exposure to passive smoking

  5. Tactics of diabetes control: Turkish immigrant experiences with chronic illness in Berlin, Germany. 

    E-Print Network [OSTI]

    Guell, Cornelia

    2009-01-01T23:59:59.000Z

    This thesis explores Turkish migrants’ practices of diabetes care in Germany. Health statistics frequently identify minority groups as vulnerable to chronic illness and Turkish-origin Germans are said to be more likely ...

  6. The influence of contagion information and behavior on older adolescents' perceptions of peers with chronic illness 

    E-Print Network [OSTI]

    Grizzle, Jonhenry Cordell

    2005-11-01T23:59:59.000Z

    To explore attributions about chronically ill peers, 545 older adolescents ages 17-26 read a short vignette describing a brief social encounter with a hypothetical peer suffering from a medical condition, and then responded ...

  7. Chlamydia pneumoniae Infection in Mice Induces Chronic Lung Inflammation, iBALT Formation, and Fibrosis

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    lymphoid aggregates in the lungs To determine the kineticslocal host defence in the lung. The Journal of pathologyterm chronic changes in the lungs. We infected C57BL/6 mice

  8. Transcranial LED therapy for cognitive dysfunction in chronic, mild traumatic brain injury: Two case reports

    E-Print Network [OSTI]

    Hamblin, Michael R.

    Two chronic, traumatic brain injury (TBI) cases are presented, where cognitive function improved following treatment with transcranial light emitting diodes (LEDs). At age 59, P1 had closed-head injury from a motor vehicle ...

  9. Viral delivery of recombinant growth hormone to rescue effects of chronic stress on hippocampal learning

    E-Print Network [OSTI]

    Saenz, Christopher M

    2012-01-01T23:59:59.000Z

    Chronic stress has been linked to variation in gene regulation in the hippocampus (HIP) among other areas. These lead to cytoskeletal and volumetric rearrangements in various nuclei of the central nervous system and are ...

  10. Maternal adrenocorticotropin, cortisol and thyroid hormone responses to chronic binge alcohol exposure throughout gestation: ovine model

    E-Print Network [OSTI]

    Tress, Ursula

    2009-05-15T23:59:59.000Z

    This study investigated the effect of chronic alcohol exposure on the responses of the maternal hypothalamus-pituitary adrenal axis (HPA-axis) and thyroid hormones throughout gestation using an ovine model. Maternal plasma concentrations of ACTH...

  11. The influence of contagion information and behavior on older adolescents' perceptions of peers with chronic illness

    E-Print Network [OSTI]

    Grizzle, Jonhenry Cordell

    2005-11-01T23:59:59.000Z

    To explore attributions about chronically ill peers, 545 older adolescents ages 17-26 read a short vignette describing a brief social encounter with a hypothetical peer suffering from a medical condition, and then responded to a series...

  12. Classification of intended phoneme production from chronic intracortical microelectrode recordings in speech-motor cortex

    E-Print Network [OSTI]

    Brumberg, Jonathan S.; Wright, E. Joe; Andreasen, Dinal S.; Guenther, Frank H.; Kennedy, Philip R.

    2011-05-12T23:59:59.000Z

    We conducted a neurophysiological study of attempted speech production in a paralyzed human volunteer using chronic microelectrode recordings. The volunteer suffers from locked-in syndrome leaving him in a state of near-total ...

  13. Why Do We Get Alzheimer's Disease?

    SciTech Connect (OSTI)

    Wyss-Coray, Tony (Stanford University) [Stanford University

    2006-01-02T23:59:59.000Z

    Neurodegenerative diseases and Alzheimer's disease (AD) in particular, are among the major health concerns of the elderly in industrialized societies. The cause of AD is unknown and no disease-modifying treatments are available. The disease is characterized clinically by a progressive dementia and pathologically by the accumulation of protein aggregates in the brain and a profound loss of nerve cells. It has also become clear recently that local immune responses are activated in the AD brain and may have a role in the disease. Our laboratory uses genetic mouse models to understand the disease process and to identify potential therapeutic targets.

  14. Comparison of LEED to Non-LEED Certified Hospitals with Regards to Patient Perspective and Financial Indicators

    E-Print Network [OSTI]

    Ulusoy, Eren

    2012-10-19T23:59:59.000Z

    ............................................................................................ 52 Table 4.12 T-test Results for the Means of Two Sample Group for Hospital Overall Rating Question .............................................................................. 53 Table 4.13 T-test Results for the Means... for Rating and Recommendation Question in the HCAHPS Survey and Inpatient Revenues per Bed ........... 83 xiii Page Table 4.32 9 LEED-Certified Hospitals Which Have Lower Rating or Recommendation Score than the Non-LEED Hospitals...

  15. Demonstration of Advanced Technologies for Multi-Load Washers in Hospitality and Healthcare – Ozone Based Laundry Systems

    SciTech Connect (OSTI)

    Boyd, Brian K.; Parker, Graham B.; Petersen, Joseph M.; Sullivan, Greg; Goetzler, W.; Sutherland, T. A.; Foley, K. J.

    2014-08-14T23:59:59.000Z

    The objective of this demonstration project was to evaluate market-ready retrofit technologies for reducing the energy and water use of multi-load washers in healthcare and hospitality facilities. Specifically, this project evaluated laundry wastewater recycling technology in the hospitality sector and ozone laundry technology in both the healthcare and hospitality sectors. This report documents the demonstration of ozone laundry system installations at the Charleston Place Hotel in Charleston, Sout Carolina, and the Rogerson House assisted living facility in Boston, Massachusetts.

  16. Acute and chronic toxicity of municipal landfill leachate as determined with bioassays and chemical analysis

    E-Print Network [OSTI]

    Schrab, Gregory Ernst

    1990-01-01T23:59:59.000Z

    municipal landfill leachates were determined to have mean estimated cumulative cancer risks on the same order of magnitude (10 4) as leachates from co-disposal and hazardous waste landfills. The use of a battery of acute and chronic toxicity bioassays..., chemical analysis, and an estimated cancer risk calculation resulted in data providing evidence that municipal solid waste landfill leachates are as acutely and chronically toxic as co-disposal and hazardous waste landfill leachates. ACKNOWLEDGEMENTS...

  17. Acute and chronic toxicity of municipal landfill leachate as determined with bioassays and chemical analysis 

    E-Print Network [OSTI]

    Schrab, Gregory Ernst

    1990-01-01T23:59:59.000Z

    ACUTE AND CHRONIC TOXICITY OF MUNICIPAL LANDFILL LEACHATE AS DETERMINED WITH BIOASSAYS AND CHEMICAL ANALYSIS A Thesis by GREGORY ERNST SCHRAB Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... of the requirements for the degree of MASTER OF SCIENCE May 1990 Major Subject: Soil Science ACUTF AND CHRONIC TOXICITY OF MUNICIPAL LANDFILL LEACHATE AS DETERMINED WITH BIOASSAYS AND CHEMICAL ANALYSIS A Thesis by GREGORY ERNST SCHRAB Approved as to style...

  18. Technical Support Document: Development of the Advanced Energy Design Guide for Small Hospitals and Healthcare Facilities--30% Guide

    SciTech Connect (OSTI)

    Bonnema, E.; Doebber, I.; Pless, S.; Torcellini, P.

    2010-03-01T23:59:59.000Z

    This Technical Support Document describes the process and methodology for the development of the Advanced Energy Design Guide for Small Hospitals and Healthcare Facilities.

  19. Factors Associated with the Decision to Hospitalize Emergency Department Patients with a Skin and Soft Tissue Infection

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    Staphylococcus aureus (MRSA). 2 Hospitalizations for SSTICo-morbidity - n (%) Any Prior MRSA infection Diabetesmagnetic resonance imaging; MRSA, methicillin-resistant S.

  20. HOSPITAL VENTILATION STANDARDS AND ENERGY CONSERVATION: A SUMMARY OF THE LITERATURE WITH CONCLUSIONS AND RECOMMENDATIONS, FY 78 FINAL REPORT

    E-Print Network [OSTI]

    DeRoos, R.L.

    2011-01-01T23:59:59.000Z

    the largest problem facing the ventilation engineer; sourcesthe heating and ventilation was already a problem. 6 In thethe hospital odor problem with regards to ventilation rates.

  1. Physiochemical disparity of mismatched HLA class I alloantigens and risk of acute graft-versus-host disease

    E-Print Network [OSTI]

    Kosmoliaptsis, V.; Jöris, M. M.; Mallon, D. H.; Lankester, A. C.; von dem Borne, P. A.; Kuball, J.; Bierings, M.; Cornelissen, J. J.; Groenendijk–Sijnke, M. E.; van der Holt, B.; Bradley, J. A.; Oudshoorn, M.; van Rood, Jon J.; Taylor, C. J.; Claas, F. H. J.

    2015-01-26T23:59:59.000Z

    ) 13 (24) 9 (16) 0.488 36 (21) 20 (12) 0.023 Diagnosis, n (%) 0.642 0.997 Acute leukemia 27 (45) 24 (44) 23 (40) 74 (43) 75 (45) Chronic leukemia 6 (10) 11 (20) 8 (14) 25 (15) 24 (14) Plasma cell disorder 5 (8) 2 (4) 3 (5) 10... 1 Physiochemical disparity of mismatched HLA class I alloantigens and risk of acute graft-versus-1 host disease following HSCT 2 Running title: Physiochemical HLA disparity and acute GvHD 3 V. Kosmoliaptsis1,2*, M. M. Jöris3,4, D. H. Mallon1, A...

  2. Age, gender, and breed as risk factors for acute and chronic equine laminitis 

    E-Print Network [OSTI]

    Alford, Patricia Lee

    1999-01-01T23:59:59.000Z

    A prospective case-control study of risk factors for laminitis analyzed data of the 258 incident cases seen at six collaborating veterinary teaching hospitals over a 32-month period. Case-control pairs were matched on institution, clinician...

  3. Neurological Complications Following Endoluminal Repair of Thoracic Aortic Disease

    SciTech Connect (OSTI)

    Morales, J. P.; Taylor, P. R.; Bell, R. E.; Chan, Y. C. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Sabharwal, T. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom); Carrell, T. W. G. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Vascular Surgery (United Kingdom); Reidy, J. F. [Guy's and St. Thomas' Foundation Hospital NHS Trust, Department of Interventional Radiology (United Kingdom)], E-mail: John.Reidy@gstt.nhs.uk

    2007-09-15T23:59:59.000Z

    Open surgery for thoracic aortic disease is associated with significant morbidity and the reported rates for paraplegia and stroke are 3%-19% and 6%-11%, respectively. Spinal cord ischemia and stroke have also been reported following endoluminal repair. This study reviews the incidence of paraplegia and stroke in a series of 186 patients treated with thoracic stent grafts. From July 1997 to September 2006, 186 patients (125 men) underwent endoluminal repair of thoracic aortic pathology. Mean age was 71 years (range, 17-90 years). One hundred twenty-eight patients were treated electively and 58 patients had urgent procedures. Anesthesia was epidural in 131, general in 50, and local in 5 patients. Seven patients developed paraplegia (3.8%; two urgent and five elective). All occurred in-hospital apart from one associated with severe hypotension after a myocardial infarction at 3 weeks. Four of these recovered with cerebrospinal fluid (CSF) drainage. One patient with paraplegia died and two had permanent neurological deficit. The rate of permanent paraplegia and death was 1.6%. There were seven strokes (3.8%; four urgent and three elective). Three patients made a complete recovery, one had permanent expressive dysphasia, and three died. The rate of permanent stroke and death was 2.1%. Endoluminal treatment of thoracic aortic disease is an attractive alternative to open surgery; however, there is still a risk of paraplegia and stroke. Permanent neurological deficits and death occurred in 3.7% of the patients in this series. We conclude that prompt recognition of paraplegia and immediate insertion of a CSF drain can be an effective way of recovering spinal cord function and improving the prognosis.

  4. Exploratory Use of Microaerosol Decontamination Technology (PAEROSOL) in Enclosed, Unoccupied Hospital Setting

    SciTech Connect (OSTI)

    Rainina, Evguenia I.; McCune, D. E.; Luna, Maria L.; Cook, J. E.; Soltis, Michele A.; Demons, Samandra T.; Godoy-Kain, Patricia; Weston, J. H.

    2012-05-31T23:59:59.000Z

    The goal of this study was to validate the previously observed high biological kill performance of PAEROSOL, a semi-dry, micro-aerosol decontamination technology, against common HAI in a non-human subject trial within a hospital setting of Madigan Army Medical Center (MAMC) on Joint Base Lewis-McChord in Tacoma, Washington. In addition to validating the disinfecting efficacy of PAEROSOL, the objectives of the trial included a demonstration of PAEROSOL environmental safety, (i.e., impact to hospital interior materials and electronic equipment exposed during testing) and PAEROSOL parameters optimization for future deployment.

  5. Implemented Continuous Commissioning Measures for Schools, Hospitals, and Office Buildings in the U.S.

    E-Print Network [OSTI]

    Oh,S.; Claridge,D.

    2014-01-01T23:59:59.000Z

    ,464 41,500 0.15 GA Fort Benning 3A (Warm & Humid) Hospital 1 398,000 69,552 0.17 MN Minneapolis 6A (Cold & Humid) Hospital 1 510,000 174,000 0.34 PA State College 5A (Cool & Humid) School 1 37,449 86,000 2.30 UT Salt Lake City 5B (Cool... of the 14th International Conference for Enhanced Building Operations, Beijing, China, September 14-17, 2014 9/15/2014 4 State City ASHRAE Climate Zone Building Type # of Buildings Conditioned Square Feet Savings $/ Year Savings $/ Year,Sqft TX Austin 2A...

  6. New Clues in Predicting Alzheimer's Disease

    ScienceCinema (OSTI)

    Jagust, William

    2013-05-29T23:59:59.000Z

    Theres a new clue in the search to identify the harbingers of Alzheimers disease. More info: http://newscenter.lbl.gov/feature-stories/2008/12/16/predict-alzheimers-disease/

  7. MENINGOCOCCAL DISEASE WHAT YOU NEED TO KNOW

    E-Print Network [OSTI]

    Missouri-Rolla, University of

    , coughing and having close social contact (living in the same household) are examples of how this disease

  8. Are You at Risk for Heart Disease?

    E-Print Network [OSTI]

    Bandettini, Peter A.

    Are You at Risk for Heart Disease? Healthy Heart, Healthy Family Nangangamba Ka Bang Magkaroon ng Are You at Risk for Heart Disease? Healthy Heart, Healthy Family Nangangamba Ka Bang Magkaroon ng Sakit sa Puso? Malusog na Puso, Malusog na Pamilya #12;Did you know that heart disease is a serious problem

  9. Coronary Heart Disease, Hypertension, Stroke, and

    E-Print Network [OSTI]

    Meagher, Mary

    Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart · Disease process: coronary and arms Myocardial infarction - heart attack, ischemia - local blood supply decreased resulting in cell

  10. Acute poisoning is a common reason for visits to emergency departments and for hospitalization

    E-Print Network [OSTI]

    Bushman, Frederic

    ACUTE POISONING jUNE 2012, Issue 6 Acute poisoning is a common reason for visits to emergency departments and for hospitalization worldwide. The prevalence of acute poisoning in Southern Africa varies between 1 and 17%1 and available evidence from Botswana suggests that acute poisoning ranks third among

  11. Evaluation of AFBC co-firing of coal and hospital wastes

    SciTech Connect (OSTI)

    Not Available

    1991-02-01T23:59:59.000Z

    The purpose of this program is to expand the use of coal by utilizing CFB (circulating fluidized bed) technology to provide an environmentally safe method for disposing of waste materials. Hospitals are currently experiencing a waste management crisis. In many instances, they are no longer permitted to burn pathological and infectious wastes in incinerators. Older hospital incinerators are not capable of maintaining the stable temperatures and residence times necessary in order to completely destroy toxic substances before release into the atmosphere. In addition, the number of available landfills which can safely handle these substances is decreasing each year. The purpose of this project is to conduct necessary research investigating whether the combustion of the hospital wastes in a coal-fired circulating fluidized bed boiler will effectively destroy dioxins and other hazardous substances before release into the atmosphere. If this is proven feasible, in light of the quantity of hospital wastes generated each year, it would create a new market for coal -- possibly 50 million tons/year.

  12. Toward a Two-Tier Clinical Warning System for Hospitalized Patients Gregory Hackmann1

    E-Print Network [OSTI]

    Lu, Chenyang

    at general hospital units. In this paper, we envision a two-tiered early warning system designed to identify significant limitations. Early warning systems based on existing medical records suffer from the sparseness two-tier system for clinical early warning and intervention. Our proposed system combines the two

  13. The internship in Corporate Communications at Beaumont Hospital, Royal Oak is affiliated with one of the

    E-Print Network [OSTI]

    Cinabro, David

    The internship in Corporate Communications at Beaumont Hospital, Royal Oak is affiliated with one atmosphere and Beaumont is a great place to work! Beaumont Internship 3601 W. 13 Mile Road Royal Oak, MI 48073 Rebecca Calappi internship coordinator rcalappi@beaumont.edu Intern with Beaumont Health System

  14. Adult Routine Physical This health plan covers routine physical exams furnished by a General Hospital, Community

    E-Print Network [OSTI]

    Oppo, Delia W.

    covered related services). 1 #12;Pediatric Routine Physical This health plan covers routine pediatric careAdult Routine Physical This health plan covers routine physical exams furnished by a General Hospital, Community Health Center, Physician, Nurse Practitioner, Nurse Midwife or Independent Lab

  15. University of Connecticut Health Center Page 1 of 2 John Dempsey Hospital

    E-Print Network [OSTI]

    Oliver, Douglas L.

    of infectivity. Other body substances are also considered hazardous. 3. Items or surfaces contaminated with blood/body fluids will be disinfected as specified in this protocol. 4. Departments in the hospital, which process or is to be ruled out for CJD, the electrodes used during the procedure are to be discarded into "Red-Bag" waste. 4

  16. Quality site seasonal report: Cherokee Indian Hospital, SFBP 4058, December 1984 through April 1985

    SciTech Connect (OSTI)

    Raymond, M.G.

    1987-10-15T23:59:59.000Z

    The active solar Domestic Hot Water (DHW) and space heating system at the Cherokee Indian Hospital was designed and constructed as part of the Solar in Federal Buildings Program (SFBP). This retrofitted system is one of eight of the systems in the SFBP selected for quality monitoring. The purpose of this monitoring effort is to document the performance of quality state-of-the-art solar systems in large federal building applications. The hospital serves the Qualla Reservation of the Cherokee Indian Tribe in Cherokee, North Carolina, near the eastern entrance to the Great Smoky Mountain National Park. Solar energy is used to preheat domestic hot water (the cafeteria is the principal load) and for space heating. The hospital is expected to have a normal year-round occupancy of 200 people (patients, medical and maintenance personnel) with some 2775 expected visitors per year. The drainback solar system has 320 Owens-Illinois evacuated-tube collectors with a gross area of 5517 square feet. Solar energy is stored in a 6335-gallon storage tank. Solar energy from storage is supplied to a 700-gallon DHW preheat tank through a heat exchanger in the storage tank, and directly to heat exchangers in the heating ducts. Auxiliary energy is supplied by two large oil-fired boilers. Performance of the system at the Cherokee Indian Hospital during the period December 1984 through April 1985 are reported.

  17. Letter to the Editor : Rapidly-deployed small tent hospitals: lessons from the earthquake in Haiti.

    SciTech Connect (OSTI)

    Rosen, Y.; Gurman , P.; Verna, E.; Elman , N.; Labor, E. (Materials Science Division); (Superior NanoBioSystems LLC); (Fast Israeli Rescue & Search Team); (Clinique Adonai); (Mass. Inst. Tech.); (Univ. Haifa)

    2012-06-01T23:59:59.000Z

    The damage to medical facilities resulting form the January 2010 earthquake in haiti necessitated the establishment of field tent hospitals. Much of the local medical infrastructure was destroyed or limited operationally when the Fast Israel Rescue and Search Team (FIRST) arrived in Haiti shortly after the January 2010 earthquake. The FIRST deployed small tent hospitals in Port-au-Prince and in 11 remote areas outside of the city. Each tent was set up in less than a half hour. The tents were staffed with an orthopedic surgeon, gynecologists, primary care and emergency care physicians, a physician with previous experience in tropical medicine, nurses, paramedics, medics, and psychologists. The rapidly deployable and temporary nature of the effort allowed the team to treat and educate, as well as provide supplies for, thousands of refugees throughout Haiti. In addition, a local Haitian physician and his team created a small tent hospital to serve the Petion Refugee Camp and its environs. FIRST personnel also took shifts at this hospital.

  18. University of Stirling PhD studentship in Diabetes and Pre-hospital Emergency Care

    E-Print Network [OSTI]

    Little, Tony

    University of Stirling PhD studentship in Diabetes and Pre-hospital Emergency Care Background Making. The Decision Making Programme is based within the University of Stirling and includes research of collaboration with academic partners, within the University of Stirling and beyond. NMAHP Research Unit

  19. Interactive Visualization of Hospital Contact Network Data on Multi-touch Displays

    E-Print Network [OSTI]

    Wyman, Chris

    in the United States every year. Understanding how infections spread in hospitals is critical to reducing of more than 100,000 people a year in the United States [2]. Epidemiologists are beginning to explore's research suggests the local water pump to be the origin of the epidemic [17]. Snow later plots the deaths

  20. HospitalityWeek April 1-5th, 2013 I N S I D E T H I S

    E-Print Network [OSTI]

    -CC): Andrew Schmidt, Greenville-Pitt County CVB, Adjunct faculty, School of Hospitality Leadership. The City bags to the Military personnel on campus. Also a Faculty Mingle at the Carolina Ale House @6pm Greenville Hospitality Community to host Meeting Profession- als International-Carolinas Chapter (MPI

  1. Controlling Diseases on Ornamental Plants.

    E-Print Network [OSTI]

    Horne, C. Wendell; Johnson, Jerral D.; Walla, Walter J.

    1979-01-01T23:59:59.000Z

    powder is used as a spray to control powdery mildew and foliage diseases. It is available as Daconil 2787?, Bravo? and Ferti-Iome Broad Spectrum Liquid Fungicide?. Formaldehyde: This is a 37 percent solution in water and methanol which is used... and move it over the loosened soil. Drain tile or iron pipe buried in the soil helps to distribute the ste~m. Heat the soil until a medium-sized potato buried several inches deep is cooked thoroughly. Use formaldehyde as manufacturer directs. Water...

  2. Diseases of Peaches and Plums.

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01T23:59:59.000Z

    Uetial ' . " ~. -~c _ '1-" ,," 'J .~. ," .. " Each year diseases destroy a large portion of the potential fruit crop in Texas. This loss begins in the orchard and continues until the fruit is con sumed. Complete lack of production on improperly sprayed trees... enough pressure to break through the bark and flow down the outside of a tree limb. Cankers will have a sour smell similar to that fol lowing a freeze. Although leaf spotting has been reported, it does not always occur. In Texas, leaf spotting has...

  3. adults cardiovascular disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    clinical issue worldwide. Acute ischaemic injury and chronic cardiomyopathies lead to permanent loss of cardiac tissue and ultimately heart failure. Current therapies...

  4. TNF-alpha protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    cerebrospinal fluid was infused into the fourth ventricle ofcognitive function in LPS-infused animals and normalized theday delivery) and chronically infused for 28 days through a

  5. Factors Associated With Newly Graduated Nurses' Intent to Leave Current Position in U.S. Acute Care Hospitals: A Descriptive Research Study Using Secondary Data Analysis

    E-Print Network [OSTI]

    Meyer, Mary N.

    2014-08-31T23:59:59.000Z

    This study aimed to identify the individual, unit-based, and hospital-based characteristics correlated with new nurse intent to leave their current positions (ITLcp) in U.S. acute care hospitals. For more than forty years, ...

  6. aquatic animal diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    William R. Pritchard Veterinary Medical Teaching Hospital University serving as a fish health specialist at the University of Arkansas; Animal Health Manager at the New...

  7. The effects of chronic and acute radiation upon the survival of C?H mice

    E-Print Network [OSTI]

    Jones, Ernest Joseph

    1967-01-01T23:59:59.000Z

    THE EFFECTS OF CHRONIC AND ACUTE RADIATION UPON THE SURVIVAL OF C H MICE A Thesis By Ernest Joseph Jones Submitted to the Graduate College of the Texas A&M University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE August 1967 Major Subject: Zoology (Physiology) THE EFFECTS OF CHRONIC AND ACUTE RADIATION UPON THE SURVIVAL OF C H MICE A Thesis By Ernest Joseph Jones Approved as to style and content by: hai of Committee) ( ber) (Head of Department...

  8. The effects of chronic and acute radiation upon the survival of C?H mice 

    E-Print Network [OSTI]

    Jones, Ernest Joseph

    1967-01-01T23:59:59.000Z

    THE EFFECTS OF CHRONIC AND ACUTE RADIATION UPON THE SURVIVAL OF C H MICE A Thesis By Ernest Joseph Jones Submitted to the Graduate College of the Texas A&M University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE August 1967 Major Subject: Zoology (Physiology) THE EFFECTS OF CHRONIC AND ACUTE RADIATION UPON THE SURVIVAL OF C H MICE A Thesis By Ernest Joseph Jones Approved as to style and content by: hai of Committee) ( ber) (Head of Department...

  9. Chronic cellular responses of rat skin to 13 Mev proton irradiation

    E-Print Network [OSTI]

    Hinkle, Donald King

    1966-01-01T23:59:59.000Z

    CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas AErM University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE August 1966 Major Subject: Laboratory Animal Medicine CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas ARM University in partial...

  10. The effect of dietary supplements on chronic bitterweed (Hymenoxys odorata) poisoning in sheep 

    E-Print Network [OSTI]

    Post, Lynn Omer

    1982-01-01T23:59:59.000Z

    Bailey Two experiments were des1gned to extablish a chron1c bitterweed dose 1n sheep and to prevent chronic bitterweed poisoning w1th dietary supplements of h1gh prote1n (20/ crude protein) and sodium sulfate. The toxicity trial consisted of five...-sodium sulfate diets did not significantly reduce the chronic bitterweed toxicity, but the soy- bean meal-sod 1um sulfate comb1nation had 1ts greatest effect on reduc- tion of bitterweed toxic1ty. However, urea appeared to potentiate the toxic effects...

  11. Imaging Lung Disease in Systemic Sclerosis

    E-Print Network [OSTI]

    Strollo, Diane; Goldin, Jonathan

    2010-01-01T23:59:59.000Z

    undergoing surgical biopsy of the lung. Radiology 1997, 205:disease. In Pathology of the Lung. Edited by Thurlbeck WM,organs, most frequently the lungs and gastrointes- tinal

  12. Enzyme replacement therapy for Pompe disease

    E-Print Network [OSTI]

    Burris, Ryan Jonathan William

    2010-01-01T23:59:59.000Z

    CALIFORNIA, SAN DIEGO Enzyme Replacement Therapy for Pompe3 1.3 Enzyme Replacement Therapy for Pompe Disease…………………… 5Receptor ERT – Enzyme Replacement Therapy LSD – Lysosomal

  13. Mathematical Model Applications to Disease and Homeland ...

    E-Print Network [OSTI]

    Mathematical Model Applications to Disease and Homeland Security The events of ... but have no data or reliable information that would help in the planning or ...

  14. Fracture, aging and disease in bone

    E-Print Network [OSTI]

    Ager, J.W.; Balooch, G.; Ritchie, R.O.

    2006-01-01T23:59:59.000Z

    on glucocorticoid-induced osteoporosis. Rheumatic DiseaseGlucocorticoid-induced osteoporosis. Endocrinol Metab. Clin.of cortico-steroid osteoporosis. A meta-analysis. Osteoporos

  15. Prognostic Significance and Normal Values of 2D Strain to Assess Right Ventricular Systolic Function in Chronic Heart Failure

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Function in Chronic Heart Failure Short Title: RV dysfunction and prognosis in CHF Soulef Guendouz, MD1 Journal 2012;76(1):127-36" #12;2 ABSTRACT Aims: Chronic heart failure (CHF) has a poor prognosis. Our aims or emergent transplantation or emergent ventricular assist-device implantation or acute heart failure. RV-2D

  16. Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart through a dual mechanism involving a direct

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Chronic heart rate reduction with ivabradine improves systolic function of the reperfused heart.berdeaux@inserm.fr inserm-00500900,version1-12Jul2010 Author manuscript, published in "European heart journal 2010 function and calcium handling to chronic heart rate reduction with ivabradine in the reperfused heart

  17. Incidence and Treatment Patterns in Hospitalizations for Malignant Spinal Cord Compression in the United States, 1998-2006

    SciTech Connect (OSTI)

    Mak, Kimberley S. [Harvard Medical School, Boston, MA (United States); Lee, Leslie K. [Division of Interventional Neuroradiology, Columbia University Medical Center, New York, NY (United States); Mak, Raymond H. [Harvard Radiation Oncology Program, Boston, MA (United States); Wang, Shuang [Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY (United States); Pile-Spellman, John [Division of Interventional Neuroradiology, Columbia University Medical Center, New York, NY (United States); Abrahm, Janet L. [Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute and Harvard Medical School Center for Palliative Care, Boston, MA (United States); Prigerson, Holly G. [Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute and Harvard Medical School Center for Palliative Care, Boston, MA (United States); Center for Psycho-oncology and Palliative Care Research, Dana-Farber Cancer Institute, Boston, MA (United States); Balboni, Tracy A., E-mail: tbalboni@lroc.harvard.edu [Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute and Harvard Medical School Center for Palliative Care, Boston, MA (United States); Center for Psycho-oncology and Palliative Care Research, Dana-Farber Cancer Institute, Boston, MA (United States); Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA (United States)

    2011-07-01T23:59:59.000Z

    Purpose: To characterize patterns in incidence, management, and costs of malignant spinal cord compression (MSCC) hospitalizations in the United States, using population-based data. Methods and Materials: Using the Nationwide Inpatient Sample, an all-payer healthcare database representative of all U.S. hospitalizations, MSCC-related hospitalizations were identified for the period 1998-2006. Cases were combined with age-adjusted Surveillance, Epidemiology and End Results cancer death data to estimate annual incidence. Linear regression characterized trends in patient, treatment, and hospital characteristics, costs, and outcomes. Logistic regression was used to examine inpatient treatment (radiotherapy [RT], surgery, or neither) by hospital characteristics and year, adjusting for confounding. Results: We identified 15,367 MSCC-related cases, representing 75,876 hospitalizations. Lung cancer (24.9%), prostate cancer (16.2%), and multiple myeloma (11.1%) were the most prevalent underlying cancer diagnoses. The annual incidence of MSCC hospitalization among patients dying of cancer was 3.4%; multiple myeloma (15.0%), Hodgkin and non-Hodgkin lymphomas (13.9%), and prostate cancer (5.5%) exhibited the highest cancer-specific incidence. Over the study period, inpatient RT for MSCC decreased (odds ratio [OR] 0.68, 95% confidence interval [CI] 0.61-0.81), whereas surgery increased (OR 1.48, 95% CI 1.17-1.84). Hospitalization costs for MSCC increased (5.3% per year, p < 0.001). Odds of inpatient RT were greater at teaching hospitals (OR 1.41, 95% CI 1.19-1.67), whereas odds of surgery were greater at urban institutions (OR 1.82, 95% CI 1.29-2.58). Conclusions: In the United States, patients dying of cancer have an estimated 3.4% annual incidence of MSCC requiring hospitalization. Inpatient management of MSCC varied over time and by hospital characteristics, with hospitalization costs increasing. Future studies are required to determine the impact of treatment patterns on MSCC outcomes and strategies for reducing MSCC-related costs.

  18. LED Surgical Task Lighting Scoping Study: A Hospital Energy Alliance Project

    SciTech Connect (OSTI)

    Tuenge, Jason R.

    2011-01-17T23:59:59.000Z

    Tungsten-halogen (halogen) lamps have traditionally been used to light surgical tasks in hospitals, even though they are in many respects ill-suited to the application due to the large percentage of radiant energy outside the visible spectrum and issues with color rendering/quality. Light-emitting diode (LED) technology offers potential for adjustable color and improved color rendition/quality, while simultaneously reducing side-effects from non-visible radiant energy. It also has the potential for significant energy savings, although this is a fairly narrow application in the larger commercial building energy use sector. Based on analysis of available products and Hospital Energy Alliance member interest, it is recommended that a product specification and field measurement procedure be developed for implementation in demonstration projects.

  19. Scoping Report: Advanced Technologies for Multi-Load Washers in Hospitality and Healthcare

    SciTech Connect (OSTI)

    Parker, Graham B.; Boyd, Brian K.; Petersen, Joseph M.; Goetzler, W.; Foley, K. J.; Sutherland, T. A.

    2013-03-27T23:59:59.000Z

    The purpose of this demonstration project is to quantify the energy savings and water efficiency potential of commercial laundry wastewater recycling systems and low-temperature detergent supply systems to help promote the adoption of these technologies in the commercial sector. This project will create a set of technical specifications for efficient multi-load laundry systems (both new and retrofit) tailored for specific applications and/or sectors (e.g., hospitality, health care). The specifications will be vetted with the appropriate Better Buildings Alliance (BBA) members (e.g., Commercial Real Estate Energy Alliance, Hospital Energy Alliance), finalized, published, and disseminated to enable widespread technology transfer in the industry and specifically among BBA partners.

  20. AFBC co-firing of coal and hospital waste. Quarterly report, February - April, 1996

    SciTech Connect (OSTI)

    Stuart, J.M.

    1996-12-31T23:59:59.000Z

    The project objective is to design, construct, install provide operator training and start-up a circulating fluidized bed combustion system at the Lebanon Pennsylvania Veteran`s Affairs Medical Center. This unit will co-fire coal and hospital waste providing lower cost steam for heating and possibly cooling (absorption chiller) and operation of a steam turbine-generator for limited power generation while providing efficient destruction of both general and infectious hospital waste. The steam generated is as follows: steam = 20,000 lb/hr; temperature = 353 F (saturated); pressure = 125 psig; and steam quality = {approximately}98.5%. During this reporting period: structural corrections have been made to make the facility meet the required building costs; and refractory bakeout was successfully completed during April 23-25, 1996 over a 54 -hour period. Operating permits will be obtained after construction has been completed.

  1. Undifferentiated Connective Tissue Disease-Associated Interstitial Lung Disease: Changes in Lung Function

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    Lung (2010) 188:143–149 DOI 10.1007/s00408-009-Tissue Disease-Associated Interstitial Lung Disease:Changes in Lung Function Brent W. Kinder • Cyrus Shariat •

  2. Network Influences on Chronic Illness Care in Large Physician Organizations: A study of the California managed care network in 2001 and 2006

    E-Print Network [OSTI]

    McCurdy, Rodney Keith

    2011-01-01T23:59:59.000Z

    The Chronic Care Model (CCM) is a comprehensive re-design ofbased methods of implementing CCM in physician practices butThe Chronic Care Model (CCM) was developed from this review

  3. CHRONIC HEAT STRESS AND PRENATAL DEVELOPMENT IN SHEEP: II. PLACENTAL CELLULARITY AND METABOLISM'J

    E-Print Network [OSTI]

    Vatnick, Itzick

    CHRONIC HEAT STRESS AND PRENATAL DEVELOPMENT IN SHEEP: II. PLACENTAL CELLULARITY AND METABOLISM'J R (Mode, 1954, Shelton, 1964; Alexander and Williams,1971). The mechanism by which heat stress affects tissue metabolism and development during heat stress. Therefore, it was the intention of the present

  4. Life Exposures to Traumatic Events and Chronic Strains Among Older Mexican-Origin Individuals

    E-Print Network [OSTI]

    Garcia, Marc

    2012-10-19T23:59:59.000Z

    affects the physical health outcomes of Latinos. This thesis examines the extent to which traumatic life events and chronic strains affect the physical health outcomes of foreign-born and native-born Mexican-origin individuals (age 45 an older) residing...

  5. Chronic Citalopram Treatment Ameliorates Depressive Behavior Associated With Light at Night

    E-Print Network [OSTI]

    Nelson, Randy J.

    . Bedrosian, Zachary M. Weil, and Randy J. Nelson The Ohio State University Columbus Chronic exposure to light was administered for 2 weeks while hamsters remained in experimental lighting conditions. Depressive-like behavior) is a relatively new phenome- non in human history, having arisen only since the widespread adoption

  6. Water balance in rats exposed to chronic centrifugation RUDY M. ORTIZ AND CHARLES E. WADE

    E-Print Network [OSTI]

    Ortiz, Rudy M.

    was observed, the lack of a change in %TBW among the three measurement periods or in water flux over the 12Water balance in rats exposed to chronic centrifugation RUDY M. ORTIZ AND CHARLES E. WADE Life; accepted in final form 22 February 2000 Ortiz, Rudy M., and Charles E. Wade. Water balance in rats exposed

  7. The extent of chronic marine oil pollution in southeastern Newfoundland waters assessed through beached

    E-Print Network [OSTI]

    Jones, Ian L.

    on their feathers is heavy fuel oil mixed with lubricants, the mixture found in bilges of large vessels. BeachedThe extent of chronic marine oil pollution in southeastern Newfoundland waters assessed through America. Oiled seabirds have washed up on beaches in Newfoundland for many decades. Most oil

  8. COMMON DISEASES OF FUR BEARING ANIMALS II. DISEASES OF CHINCHILLAS, NUTRIA, AND RABBITS*

    E-Print Network [OSTI]

    COMMON DISEASES OF FUR BEARING ANIMALS II. DISEASES OF CHINCHILLAS, NUTRIA, AND RABBITS* T. J. Pridhamt, Joan Buddt, and L. H. A. Karstadt DISEASES OF THE CHINCHILLA BACTERIAL INFECTIONS and errors in management are the most common causes of death in the chinchillas submitted to this laboratory. LISTERIOSIS

  9. Coronary Heart Disease, Hypertension, Stroke, and

    E-Print Network [OSTI]

    Meagher, Mary

    Coronary Heart Disease, Hypertension, Stroke, and Diabetes #12;Coronary Heart Disease: Overview to illnesses caused by atherosclerosis ­ Narrowing of coronary arteries, the vessels that supply the heart that radiates across the chest and arms Ø Myocardial infarction - heart attack, ischemia - local blood supply

  10. X-ray atlas of rheumatic diseases

    SciTech Connect (OSTI)

    Dihlmann, W.

    1986-01-01T23:59:59.000Z

    This atlas comprises instructive X-rays of the various inflammatory rheumatic joint diseases in all stages at the extremities and the spinal column. In addition, the complex pattern of the wide range of arthroses, also known as degenerative rheumatic disease is included. Besides the instructive pointers to X-ray diagnosis, the book is also a guide to differential diagnosis. Hence, this book is actually an X-ray atlas of joint diseases in general. Selected Contents: Introduction: What Does ''Rheumatism'' Actually Mean./Radiographic Methodology in Rheumatic Diseases of the Locomotor System/The Mosaic of Arthritis/Adult Rheumatoid Arthritis/Seronegative Spondylarthritis/Classic Collagen Diseases/Enthesiopathies/Gout-Pseudogout

  11. HOSPITAL VENTILATION STANDARDS AND ENERGY CONSERVATION: A SUMMARY OF THE LITERATURE WITH CONCLUSIONS AND RECOMMENDATIONS, FY 78 FINAL REPORT

    E-Print Network [OSTI]

    DeRoos, R.L.

    2011-01-01T23:59:59.000Z

    ALLANDER, C. and E. ABEL. Ventilation in the hospital. Sj~kh1955. BLOWERS, R. et a1. Ventilation of operating theatres.Letter: Operating theatre ventilation. 1(655): 1053-l05 L f,

  12. Clinical Trials Support -Research Associate II Animal Cancer Center Oncology Clinical Trials Program -Colorado State University Veterinary Teaching Hospital

    E-Print Network [OSTI]

    Stephens, Graeme L.

    Clinical Trials Support - Research Associate II Animal Cancer Center Oncology Clinical Trials Program - Colorado State University Veterinary Teaching Hospital Oncology Clinical Trials Program the daily schedule for the clinical trials rotation o Patient care including, obtaining owner history

  13. Journal of Wildlife Diseases, 41(1), 2005, pp. 4857 Wildlife Disease Association 2005

    E-Print Network [OSTI]

    Mladenoff, David

    REGION Michael D. Samuel,1,2,4 Daniel J. Shadduck,1 Diana R. Goldberg,1 and William P. Johnson3 1 US of methods developed in laboratory challenge trials (Samuel et al., 2003a) and a serotype- specific caerulescens) breeding colo- nies (Samuel et al., 1999a). In addition, chronic transmission and infection might

  14. Cardiac Procedures among American Indians and Alaska Natives compared to Non-Hispanic Whites Hospitalized with Ischemic Heart Disease in California

    E-Print Network [OSTI]

    Jolly, Stacey; Kao, Chi; Bindman, Andrew B.; Korenbrot, Carol

    2010-01-01T23:59:59.000Z

    catheterization, percutaneous coronary intervention, and88.57); percutaneous coronary intervention (37.22, 37.23,catheterization or percutaneous coronary intervention in the

  15. A Semiautomated Framework for Integrating Expert Knowledge into Disease Marker Identification

    SciTech Connect (OSTI)

    Wang, Jing; Webb-Robertson, Bobbie-Jo M.; Matzke, Melissa M.; Varnum, Susan M.; Brown, Joseph N.; Riensche, Roderick M.; Adkins, Joshua N.; Jacobs, Jon M.; Hoidal, John R.; Scholand, Mary Beth; Pounds, Joel G.; Blackburn, Michael R.; Rodland, Karin D.; McDermott, Jason E.

    2013-10-01T23:59:59.000Z

    Background. The availability of large complex data sets generated by high throughput technologies has enabled the recent proliferation of disease biomarker studies. However, a recurring problem in deriving biological information from large data sets is how to best incorporate expert knowledge into the biomarker selection process. Objective. To develop a generalizable framework that can incorporate expert knowledge into data-driven processes in a semiautomated way while providing a metric for optimization in a biomarker selection scheme. Methods. The framework was implemented as a pipeline consisting of five components for the identification of signatures from integrated clustering (ISIC). Expert knowledge was integrated into the biomarker identification process using the combination of two distinct approaches; a distance-based clustering approach and an expert knowledge-driven functional selection. Results. The utility of the developed framework ISIC was demonstrated on proteomics data from a study of chronic obstructive pulmonary disease (COPD). Biomarker candidates were identified in a mouse model using ISIC and validated in a study of a human cohort. Conclusions. Expert knowledge can be introduced into a biomarker discovery process in different ways to enhance the robustness of selected marker candidates. Developing strategies for extracting orthogonal and robust features from large data sets increases the chances of success in biomarker identification.

  16. Investigating organizational quality improvement systems, patient empowerment, organizational culture, professional involvement and the quality of care in European hospitals: the 'Deepening our Understanding of Quality Improvement in Europe (DUQuE)' project

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    of hospital quality management systems in the Netherlands.accreditation systems, orga- nisational quality management

  17. Study of collagen structure in canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Hadian, Mojtaba

    2009-01-01T23:59:59.000Z

    Myxomatous mitral valve disease (MMVD) is the single most common acquired cardiac disease of dogs, and is a disease of significant veterinary importance. It also bears close similarities to mitral valve prolapse in humans ...

  18. Behavioral impulsivity and hallucinations : insights from Parkinson's disease

    E-Print Network [OSTI]

    Ashourian, Paymon

    2011-01-01T23:59:59.000Z

    Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, ...

  19. Geothermal heating project at St. Mary's Hospital, Pierre, South Dakota. Final report

    SciTech Connect (OSTI)

    Not Available

    1984-12-01T23:59:59.000Z

    St. Mary's Hospital, Pierre, South Dakota, with the assistance of the US Department of Energy, drilled a 2176 ft well into the Madison Aquifer ot secure 108/sup 0/F artesian flow water at 385 gpm (475 psig shut-in pressure). The objective was to provide heat for domestic hot water and to space heat 163,768 sq. ft. Cost savings for the first three years were significant and, with the exception of a shutdown to replace some corroded pipe, the system has operated reliably and continuously for the last four years.

  20. Hospital Triage in the First 24 Hours after a Nuclear or Radiological Disaster

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School football Highdefault Sign InData inmaxHorizontal PlateHospital

  1. Chemicals for Plant Disease Control at Home

    E-Print Network [OSTI]

    Ong, Kevin

    2007-10-30T23:59:59.000Z

    common chemical names and the corresponding chemical name for each active ingredient. Kevin Ong* ?Assistant Professor and Extension Plant Pathologist, The Texas A&M University System Table 1. Plant disease control chemicals. Common name Chemical name 1...

  2. HLB in Argentina: a New Disease Outbreak

    E-Print Network [OSTI]

    2014-01-01T23:59:59.000Z

    Vol. 1 (2014) HLB in Argentina: a New Disease Outbreak Outi,E. 6 SENASA, Bs. As. Argentina MAGyP Bs. As INTA Montecarlo,Paraná, 300 km away from Argentina’s Northeastern border. In

  3. Radiation Therapy After Breast-Conserving Surgery: Does Hospital Surgical Volume Matter? A Population-Based Study in Taiwan

    SciTech Connect (OSTI)

    Chien, Chun-Ru [Section of Health Services Research, Department of Biostatistics, Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Department of Radiation Oncology, China Medical University Hospital, and School of Medicine, China Medical University, Taichung, Taiwan (China); Pan, I-Wen [Section of Health Services Research, Department of Biostatistics, Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Tsai, Yi-Wen [Center of Health Policy Research and Development, National Health Research Institutes, Miaoli County, Taiwan (China); Institute of Health and Welfare Policy, National Yang-Ming University Hospital, Taipei, Taiwan (China); Tsai, Teressa [Center of Health Policy Research and Development, National Health Research Institutes, Miaoli County, Taiwan (China); Liang, Ji-An [Department of Radiation Oncology, China Medical University Hospital, and School of Medicine, China Medical University, Taichung, Taiwan (China); Buchholz, Thomas A. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX (United States); Shih, Ya-Chen Tina, E-mail: yashih@mdanderson.org [Section of Health Services Research, Department of Biostatistics, Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, TX (United States)

    2012-01-01T23:59:59.000Z

    Purpose: To examine the association between hospital surgical volume and the use of radiation therapy (RT) after breast-conserving surgery (BCS) in Taiwan. Methods and Materials: We used claims data from the National Health Insurance program in Taiwan (1997-2005) in this retrospective population-based study. We identified patients with breast cancer, receipt of BCS, use of radiation, and the factors that could potentially associated with the use of RT from enrollment records, and the ICD-9 and billing codes in claims. We conducted logistic regression to examine factors associated with RT use after BCS, and performed subgroup analyses to examine whether the association differs by medical center status or hospital volumes. Results: Among 5,094 patients with newly diagnosed invasive breast cancer who underwent BCS, the rate of RT was significantly lower in low-volume hospitals (74% vs. 82%, p < 0.01). Patients treated in low-volume hospitals were less likely to receive RT after BCS (odds ratio = 0.72, 95% confidence interval = 0.62-0.83). In addition, patients treated after the implementation of the voluntary pay-for-performance policy in 2001 were more likely to receive RT (odds ratio = 1.23; 95% confidence interval = 1.05-1.45). Subgroup analyses indicated that the high-volume effect was limited to hospitals accredited as non-medical centers, and that the effect of the pay-for-performance policy was most pronounced among low-volume hospitals. Conclusions: Using population-based data from Taiwan, our study concluded that hospital surgical volume and pay-for-performance policy are positively associated with RT use after BCS.

  4. Hemodynamic characterization of chronic bile duct-ligated rats: effect of pentobarbital sodium

    SciTech Connect (OSTI)

    Lee, S.S.; Girod, C.; Braillon, A.; Hadengue, A.; Lebrec, D.

    1986-08-01T23:59:59.000Z

    Systemic and splanchnic hemodynamics of the chronic bile duct-ligated rat were characterized by radioactive microspheres. Conscious and pentobarbital sodium-anesthetized, bile duct-ligated and sham-operated rats had cardiac output and regional organ blood flows determined. The conscious bile duct-ligated rat compared with the sham-operated showed a hyperdynamic circulation with an increased cardiac output and portal tributary blood flow. Pentobarbital sodium anesthesia induced marked hemodynamic changes in both sham-operated and bile duct-ligated rats. The latter group was especially sensitive to its effects; thus, comparison of cardiac output and portal tributary blood flow between anesthetized bile duct-ligated and sham-operated rats showed no significant differences. The authors conclude that the rat with cirrhosis due to chronic bile duct ligation is an excellent model for hemodynamic investigations but should be studied in the conscious state, since pentobarbital sodium anesthesia eliminated the hyperdynamic circulation.

  5. Restoration of Endangered White Abalone, Haliotis sorenseni: Resource Assessment, Genetics, Disease and Culture of Captive Abalone

    E-Print Network [OSTI]

    Burton, Ronald S.; McCormick, Thomas B.; Moore, James D.; Friedman, Carolyn S.

    2008-01-01T23:59:59.000Z

    Haliotis sorenseni: Resource Assessment, Genetics, Disease,Haliotis sorenseni: Resource Assessment, Genetics, Disease,Haliotis sorenseni: Resource Assessment, Genetics, Disease,

  6. adult celiac disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: with a dietitian or physician who specializes in celiac disease. People with celiac disease should always read food for Celiac Awareness; Cynthia Kupper,...

  7. arthritis disease activity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    systemic, inflammatory disease causing disability. Identifying factors that influence the impact of the disease is important for planning adequate (more) Kuhlow, Heide 2007-01-01...

  8. ASSISTANT/ASSOCIATE/FULL PROFESSOR Diabetes, Obesity, Metabolic Disease

    E-Print Network [OSTI]

    Cinabro, David

    ASSISTANT/ASSOCIATE/FULL PROFESSOR Diabetes, Obesity, Metabolic Disease Department strengths in diabetes, obesity and metabolic disease. Outstanding candidates with expertise

  9. Integrated Molecular Signature of Disease: Analysis of Influenza...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Disease: Analysis of Influenza Virus-Infected Macaques through Functional Genomics and Integrated Molecular Signature of Disease: Analysis of Influenza Virus-Infected...

  10. Structural genomics of infectious disease drug targets: the SSGCID...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of infectious disease drug targets: the SSGCID. Structural genomics of infectious disease drug targets: the SSGCID. Abstract: The NIAID-funded SSGCID is a consortium established to...

  11. The Seattle Structure Genomics Center for Infectious Disease...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Seattle Structure Genomics Center for Infectious Disease (SSGCID). The Seattle Structure Genomics Center for Infectious Disease (SSGCID). Abstract: The NIAID-funded Seattle...

  12. alzheimers disease amyloid: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alzheimer???s Disease Medications. Open Access Theses and Dissertations Summary: ??The brain of Alzheimer???s disease (AD) is characterized by accumulations of ??-amyloid peptide...

  13. alzheimer disease current: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diagnosis of Alzheimers disease: CiteSeer Summary: update on combining genetic and brain-imaging measures Gary W. Small, MD Diagnosis of Alzheimers disease is often missed...

  14. alzheimer disease amyloid: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Alzheimer???s Disease Medications. Open Access Theses and Dissertations Summary: ??The brain of Alzheimer???s disease (AD) is characterized by accumulations of ??-amyloid peptide...

  15. anthracnose disease control: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease of papaya Babak Madani a,*, Mahmud Tengku Muda Mohamed a,**, Alan R. Biggs c , Jugah Kadir October 2013 Keywords: Papaya Anthracnose Calcium Disease incidence...

  16. anthracnose disease caused: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease of papaya Babak Madani a,*, Mahmud Tengku Muda Mohamed a,**, Alan R. Biggs c , Jugah Kadir October 2013 Keywords: Papaya Anthracnose Calcium Disease incidence...

  17. A Systems Biology Approach to Infectious Disease Research: Innovating...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems Biology Approach to Infectious Disease Research: Innovating the Pathogen-Host Research Paradigm. A Systems Biology Approach to Infectious Disease Research: Innovating the...

  18. Molecular pathogenesis of Helicobacter hepaticus induced liver disease

    E-Print Network [OSTI]

    Boutin, Samuel R., 1952-

    2005-01-01T23:59:59.000Z

    Helicobacter hepaticus infection of A/JCr mice is a model of liver cancer resulting from chronic active inflammation. We monitored hepatic global gene expression profiles and correlated them to histological liver lesions ...

  19. Infarct size and regional perfusion following coronary occlusion in the chronically sympathectomized canine ventricle

    E-Print Network [OSTI]

    Beck, Linda Yvonne

    1978-01-01T23:59:59.000Z

    OF THE LITERATURE Present State of the Problem Effects of the Autonomic Nervous System on the Normal Heart The Importance of the Autonomic Nervous, System Autonomic Influences During Coronary Insuffiency 1. 0 11 12 METHODS 18 Infarct Size Study Regional... of the thoracic vagus nerves and stellate gangli. a before (upper tracings) and after (lower tracings) cardiac denervation by the method used in the chronic denervation experiments 25 Diagram of canine heart and autonomic nerve supply to the left side...

  20. Chronic stress and age-related increases in the proinflammatory cytokine interleukin-6

    E-Print Network [OSTI]

    Kiecolt-Glaser, J. K.; Preacher, K. J.; MacCallum, R. C.; Atkinson, Cathie; Malarkey, W. B.; Glaser, R.

    2003-01-01T23:59:59.000Z

    Chronic stress and age-related increases in the proinflammatory cytokine IL-6 Janice K. Kiecolt-Glaser* ?? , Kristopher J. Preacher ? , Robert C. MacCallum ? , Cathie Atkinson*, William B. Malarkey ?H20648 , and Ronald Glaser ?? ** ?? Departments... of *Psychiatry, H20648 Internal Medicine, and **Molecular Virology, Immunology, and Medical Genetics, Ohio State University College of Medicine, Columbus, OH 43210; ? Department of Psychology, ? Institute for Behavioral Medicine Research, and ? Comprehensive...

  1. Creative coping: a description of experiences of families coping with chronic illness in a child

    E-Print Network [OSTI]

    McGough, Marnique

    2006-08-16T23:59:59.000Z

    CREATIVE COPING: A DESCRIPTION OF EXPERIENCES OF FAMILIES COPING WITH CHRONIC ILLNESS IN A CHILD A Dissertation by MARNIQUE MCGOUGH Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... by MARNIQUE MCGOUGH Submitted to Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Approved as to style and content by: ______________________________ ______________________ William R. Nash...

  2. Interstitial fluid pressure within the coronary dermis of the horse with chronic laminitis

    E-Print Network [OSTI]

    Olivier, Ann

    1987-01-01T23:59:59.000Z

    (IFP) in the coronary band at the toe and heel positions of the catheter in the forefeet of normal horses (Group 1, N 10) and horses with chronic laminitis (Group 2, N~10) 28 LIST OF FIGURES Figure Page I. Wick-in-needle catheter 17 2. Mean... manifestations including pain, various endocrine and electrolyte imbalances , hypertension, renal dysfunction& anorexia and depression 2, 3, 11-17 are also encountered The affected foot may undergo mechanical collapse as the relationship of the structures...

  3. Effects of chronic cadmium exposure on the conditioned reinforcing properties of morphine and fentanyl in rats

    E-Print Network [OSTI]

    Miller, Dennis K

    1997-01-01T23:59:59.000Z

    &M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to style and content by: ck R. Nation (C ir of Committee) Gerald D. Frye (Member) Paul J. Wellman (Member) Paul J. Wellman (Head of Department... the metal (Nation, Livermore, Bratton, & Schenk, 1996). A similar attenuation was shown with repeated cocaine exposure--the development of locomotor sensitization. Rats that received chronic cadmium exposure required more cocaine administration sessions...

  4. Improved Cognitive Function After Transcranial, Light-Emitting Diode Treatments in Chronic, Traumatic Brain Injury: Two Case Reports

    E-Print Network [OSTI]

    Naeser, Margaret A.

    Objective: Two chronic, traumatic brain injury (TBI) cases, where cognition improved following treatment with red and near-infrared light-emitting diodes (LEDs), applied transcranially to forehead and scalp areas, are ...

  5. Microvascular function after treatment with an angiogenic factor, TP508, in a porcine model of chronic ischemia

    E-Print Network [OSTI]

    Makarski, Lori Ann

    2003-01-01T23:59:59.000Z

    function of microvessels in ischemic myocardium treated with TP508, (treated, TR) when compared to untreated ischemic myocardium (non-treated, NT) and non-ischemic myocardium from control pigs (CON). Adult Yucatan miniature swine were subjected to chronic...

  6. Images of pain: Exploration of the characteristics and functions of pain-related mental imagery in chronic pain 

    E-Print Network [OSTI]

    Gosden, Thomas

    2008-01-01T23:59:59.000Z

    Introduction A recent study by Potter et al. (in submission) reported that many chronic pain sufferers experience a spontaneous mental image of their pain, and that these individuals also report higher levels of anxiety ...

  7. AFBC co-firing of coal and hospital waste. Quarterly report, August--October 1995

    SciTech Connect (OSTI)

    Stuart, J.M.

    1996-03-01T23:59:59.000Z

    The project objective is to design, construct, install provide operator training and start-up a circulating fluidized bed combustion system at the Lebanon Pennsylvania Veteran`s Affairs Medical Center. This unit will co-fire coal and hospital waste providing lower cost steam for heating and possibly cooling (absorption chiller) and operation of a steam turbine-generator for limited power generation. This would permit full capacity operation of the FBC year round in spite of the VA laundry that was shut down as well as efficient destruction of both general and infectious hospital waste and steam generation. The State permitting process required for construction will be completed in early November to allow installation and construction to be completed. Operating permits will be obtained after construction has been completed. A request for proposal for stack sampling and biospore tests was released to four (4) vendors in mid-October. The proposals shall be reviewed during November and the stack sampler will be selected. Funding was approved as of August 1, 1995. Construction and installation resumed on August 21, 1995 at the LVAMC. Construction and installation continues and will be completed by late December 1995.

  8. AFBC co-firing of coal and hospital waste. Quarterly report, November 1995--January 1996

    SciTech Connect (OSTI)

    Stuart, J.M.

    1996-03-01T23:59:59.000Z

    The project objective is to design, construct, install provide operator training and start-up a circulating fluidized bed combustion system at the Lebanon Pennsylvania Veteran`s Affairs Medical Center. This unit will co-fire coal and hospital waste providing lower cost steam for heating and possibly cooling (absorption chiller) and operation of a steam turbine-generator for limited power generation while providing efficient destruction of both general and infectious hospital waste. Operating permits will be obtained after construction has been completed. The stack sampler has been selected. This vendor is currently developing the testing protocol. Severe weather in December and January caused work delays to the project, especially to outside work The fabrication and installation of the stack are complete. Only the insulation of the stack remains to be done. Budget problems began to occur in late January. Correction of this situation should occur shortly in February or March. A current schedule for the project is included with this report.

  9. An investigation of the potentiating effects of ethanol on a chronic exposure of rats to 1,1,1-trichloroethane

    E-Print Network [OSTI]

    Walker, DeWayne Harold

    1973-01-01T23:59:59.000Z

    AN INVESTIGATION OF THE POTENTIATING EFFECTS OF ETHANOL ON A CHRONIC EXPOSURE OF RATS TO 1, 1&I-TRICHLOROETHANE A Thesis by DEWAYNE HAROLD WALKER Submitted to the Graduate College of Texas AFM University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE August 1973 Major Subject: Laboratory Animal Medicine AN INVESTIGATION OF THE POTENTIATING EFFECTS OF ETHANOL ON A CHRONIC EXPOSURE OF RATS TQ 1&1, 1-TRICHLOROETHANE A Thesis by DENAYNE HAROLD WALKER...

  10. Bridging the Gap between Food Safety and Quality: Context and Potential Effects of Chronic Disease on Foodborne Illness and Health Outcomes

    E-Print Network [OSTI]

    Cummings, Patricia

    2014-01-01T23:59:59.000Z

    in LA County Food Services Contracts March 22, 2011. Motiona condi- tion for food service contract execution. 9,12 In

  11. 8th International Symposium on Growth and Nutrition in Children with Chronic Renal Disease: 28–30 May 2009, Oviedo, Asturias, Spain

    E-Print Network [OSTI]

    Santos, Fernando; Kaskel, Frederick J.; Mak, Robert H.; Caldas, Alberto

    2010-01-01T23:59:59.000Z

    2009, Oviedo, Asturias, Spain Fernando Santos & Frederick J.of Oviedo, Oviedo, Asturias, Spain F. J. Kaskel Montefiores/n, 33006 Oviedo, Asturias, Spain e-mail: fsantos@uniovi.es

  12. Potential role of differential medication use in explaining excess risk of cardiovascular events and death associated with chronic kidney disease: a cohort study

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    N = 446 percutaneous coronary intervention, N = 260 cor-8.87 to 10.34) Percutaneous coronary intervention 4.25 (3.17outcomes among percutaneous coronary intervention patients

  13. Asthma is a widespread public health problem that has continued to increase in Texas and nationwide. In Texas, asthma affects more children than any other chronic disease and

    E-Print Network [OSTI]

    . This pilot project is being funded by Region 6, Environmental Protection Agency (EPA). Your part risk in homes, and strategies on how families can reduce or even remove these triggers or risks from assessment of their home's indoor environment to identify potential triggers and lead risks. These same

  14. Major prime contractors have developed a plan to address Hanford Beryllium exposure and are continuing to improve the Chronic Beryllium Disease Prevention Plan (CBDPP)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh SchoolIn12electron 9November 6,Bradbury

  15. Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells

    SciTech Connect (OSTI)

    Person, Rachel J.; Tokar, Erik J.; Xu, Yuanyuan; Orihuela, Ruben; Ngalame, Ntube N. Olive; Waalkes, Michael P., E-mail: waalkes@niehs.nih.gov

    2013-12-01T23:59:59.000Z

    Cadmium is a known human lung carcinogen. Here, we attempt to develop an in vitro model of cadmium-induced human lung carcinogenesis by chronically exposing the peripheral lung epithelia cell line, HPL-1D, to a low level of cadmium. Cells were chronically exposed to 5 ?M cadmium, a noncytotoxic level, and monitored for acquired cancer characteristics. By 20 weeks of continuous cadmium exposure, these chronic cadmium treated lung (CCT-LC) cells showed marked increases in secreted MMP-2 activity (3.5-fold), invasion (3.4-fold), and colony formation in soft agar (2-fold). CCT-LC cells were hyperproliferative, grew well in serum-free media, and overexpressed cyclin D1. The CCT-LC cells also showed decreased expression of the tumor suppressor genes p16 and SLC38A3 at the protein levels. Also consistent with an acquired cancer cell phenotype, CCT-LC cells showed increased expression of the oncoproteins K-RAS and N-RAS as well as the epithelial-to-mesenchymal transition marker protein Vimentin. Metallothionein (MT) expression is increased by cadmium, and is typically overexpressed in human lung cancers. The major MT isoforms, MT-1A and MT-2A were elevated in CCT-LC cells. Oxidant adaptive response genes HO-1 and HIF-1A were also activated in CCT-LC cells. Expression of the metal transport genes ZNT-1, ZNT-5, and ZIP-8 increased in CCT-LC cells culminating in reduced cadmium accumulation, suggesting adaptation to the metal. Overall, these data suggest that exposure of human lung epithelial cells to cadmium causes acquisition of cancer cell characteristics. Furthermore, transformation occurs despite the cell's ability to adapt to chronic cadmium exposure. - Highlights: • Chronic cadmium exposure induces cancer cell characteristics in human lung cells. • This provides an in vitro model of cadmium-induced human lung cell transformation. • This occurred with general and lung specific changes typical for cancer cells. • These findings add insight to the relationship between cadmium and lung cancer.

  16. Everyday Healthy Living Do you or someone in your family live with a chronic

    E-Print Network [OSTI]

    Hardy, Christopher R.

    diseases--such as heart disease, stroke, cancer, diabetes, asthma, and arthritis--are among the most common your risk of diabetes, heart attack, stroke, or cancer by 80% if you would just do 4 things: Engage have because your father had a heart attack at age 48 and your grandmother's history of diabetes. You

  17. A Method to Estimate the Chronic Health Impact of Air Pollutants in

    E-Print Network [OSTI]

    information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by its trade name standards ­ that affect indoor air quality (IAQ). Methods: Available disease incidence and disease impact

  18. CPL -COMISSO PERMANENTE DE LICITAO Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    /604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail hubcpl@bol.com.br. Pregão Nº. 378/2013 HOSPITAL

  19. CPL -COMISSO PERMANENTE DE LICITAO Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    /604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail hubcpl@bol.com.br. Pregão Nº. 331/2014 HOSPITAL

  20. CPL -COMISSO PERMANENTE DE LICITAO Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    /604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail hubcpl@bol.com.br. HOSPITAL UNIVERSITÁRIO DE

  1. CPL -COMISSO PERMANENTE DE LICITAO Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    /604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail hubcpl@bol.com.br. Pregão Nº. 305/2014 HOSPITAL

  2. ULIC-UNIDADE DE LICITAES Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    ULIC- UNIDADE DE LICITA��ES Hospital universitário de Brasília - SGAN Quadras 604/604, Asa Norte

  3. CPL -COMISSO PERMANENTE DE LICITAO Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    /604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail hubcpl@bol.com.br. Pregão Nº. 371/2013 HOSPITAL

  4. CPL -COMISSO PERMANENTE DE LICITAO Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    /604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail hubcpl@bol.com.br. Pregão Nº. 333/2013 HOSPITAL

  5. CPL -COMISSO PERMANENTE DE LICITAO Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    /604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail hubcpl@bol.com.br. Pregão Nº. 359/2013 HOSPITAL

  6. CPL -COMISSO PERMANENTE DE LICITAO Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    /604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail hubcpl@bol.com.br. Pregão Nº.368/2013 HOSPITAL

  7. CPL -COMISSO PERMANENTE DE LICITAO Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    /604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail hubcpl@bol.com.br. Pregão Nº. 341/2013 HOSPITAL

  8. ULIC UNIDADE DE LICITAES Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    ULIC ­ UNIDADE DE LICITA��ES Hospital universitário de Brasília - SGAN Quadras 604/604, Asa Norte

  9. CPL -COMISSO PERMANENTE DE LICITAO Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    /604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail hubcpl@bol.com.br. Pregão Nº. 392/2013 HOSPITAL

  10. CPL -COMISSO PERMANENTE DE LICITAO Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    /604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail hubcpl@bol.com.br. Pregão Nº. 348/2013 HOSPITAL

  11. CPL -COMISSO PERMANENTE DE LICITAO Hospital universitrio de Braslia -SGAN Quadras 604/604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail

    E-Print Network [OSTI]

    Maier, Rudolf Richard

    /604, Asa Norte, CEP: 70840901 telefone (61)34485344, e-mail hubcpl@bol.com.br. Pregão Nº. 372/2013 HOSPITAL

  12. Thomas E. Hinds Although many diseases attack aspen, relatively few

    E-Print Network [OSTI]

    DISEASES Thomas E. Hinds Although many diseases attack aspen, relatively few kill or seriously of aspen, whereas there are subtle differ- ences in distribution between the important decay fungi. Foliage Diseases Fungus Diseases Many fungi are capable of attacking aspen leaves, from juvenile growth

  13. AFBC co-firing of coal and hospital waste: Quarterly report, 1 May 1996-31 July, 1996

    SciTech Connect (OSTI)

    Stuart, J.M.

    1996-12-31T23:59:59.000Z

    The project objective is to design, construct, install, provide operator training and start-up a circulating fluidized bed combustion system at the Lebanon Pennsylvania Veteran`s Affairs Medical Center. This unit will co-fire coal and hospital waste providing lower cost steam for heating and possibly cooling (absorption chiller) and operation of a steam turbine-generator for limited power generation while providing efficient destruction of both general and infectious hospital waste. This quarterly report describes activities completed in the design, procure, install and start-up phase.

  14. AFBC co-firing of coal and hospital waste. Quarterly progress report, August 1--October 31, 1996

    SciTech Connect (OSTI)

    NONE

    1997-06-01T23:59:59.000Z

    The project objective is to design, construct, install, provide operator training and start-up a circulating fluidized bed combustion system at the Lebanon Pennsylvania Veteran`s Affairs Medical Center. This unit will co-fire coal and hospital waste providing lower cost steam for heating and possibly cooling (absorption chiller) and operation of a steam turbine-generator for limited power generation while providing efficient destruction of both general and infectious hospital waste. The steam generated as follows: (1) Steam = 20,000 lb/hr, (2) Temperature = 353 F (saturated), (3) Pressure = 125 psig, and (4) Steam quality = {approximately}98.5%.

  15. Like that circuit maze, Newman's career path--set in motion by her

    E-Print Network [OSTI]

    fruitful." One particular environment that currently holds Newman's attention is the human lung. She fibrosis (CF), a chronic lung disease. It also is an im- portant hospital-acquired bacterium for people who are explor- ing how these bacteria manage to thrive in the lungs of CF patients. "So far, it seems that one

  16. Physical Activity and Insulin Sensitivity. The RISC Study

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, CH-1211 Geneva, Switzerland (Dr Golay-3Jul2008 Author manuscript, published in "Diabetes 57 (2008) 2613-2618" DOI : 10.2337/db07-1605 #12;Abstract OBJECTIVE--Physical activity is a modifiable risk factor for type 2 diabetes, partly through its

  17. Effect of chronic gamma irradiation on leukocyte chromosomes of the Spanish goat

    E-Print Network [OSTI]

    Wortman, Donna Chesser

    1967-01-01T23:59:59.000Z

    ~ Damage to human chromosomes ha s a iso been reported a f t er. radiation therapy, both in acute and fractionated doses, for a variety o f ailments ( 7, 8, 9, ] 0 ) . Chromos oma 1 a berrat ions have resulted from human exposures to such. i nternal... to be elucidate&1. lt has also been recorded in at leasL five cases that the Ph1 chromosome has presaged the clinical appearance of chronic myelogenous leukemia (23). Another possibly significant ef feet of somatic chromosomal aberrations is that they may...

  18. Corticosterone mediates the effects of chronic stress on Theiler's virus in mice

    E-Print Network [OSTI]

    Satterlee, Danielle Marie

    2013-02-22T23:59:59.000Z

    have shown chronic stress increases susceptibility to herpes simplex and influenza viruses in mice and that this effect is mediated by the stress hormone corticosterone (DeLano, 8 Mallery, 1998; Sheridan, Dobbs, Jung, Chu, Konstantinos, Padgett... Scores: Experiment 1 I o O V) rii O C O lA L I/R I/O N/R Condition N/C Fig. 3. The mean worst clinical scores are compared for each group: infected-restrained (I/R), infected-control (I/C), noninfected-restrained (N/R), and noninfected...

  19. Effect of chronic exposure to low levels of ethylene on cotton during germination and early development

    E-Print Network [OSTI]

    Cowan, Elaine Nan

    1979-01-01T23:59:59.000Z

    for the degree of NASTER OF SCIENCE Auoust 1979 . "iajor Subject: Plant Physiology THE EFFECT OF CHRONIC EXPOSURE TO LON LEVELS OF ETHYLENE ON COTTON DURING GERMINATION AND EARLY DEVELOPMENT A Thesis by ELAINF NAN CONAN Approved as to sty1e and content... and Ryan indicated that endopeptidase reached a peak in activity 10 days after planting. Fumigation with 0. 5 ul/1 ethylene for 5 days prior to harvest inhibited this in- crease in activity. The present study was undertaken to deter- mine...

  20. Huntington's disease: underlying molecular mechanisms and emerging

    E-Print Network [OSTI]

    Morimoto, Richard

    transcriptional mechanism also dictates the expression of polygluta- mine proteins. Here, we summarize the key with no disease modifying treatments available [1]. At the molecular level, HD is caused by a CAG trinu- cleotide is composed of proteins involved in transcription, DNA maintenance, cell cycle regulation, cellular orga

  1. News you can use Disease management

    E-Print Network [OSTI]

    Isaacs, Rufus

    DISEASE MANAGEMENT PAGE 9 CALENDAR A u g u s t 2 5 , 2 0 1 0 V O L 1 , I S S U E 1 5 A Michigan State. Elm Valley Road in Suttons Bay. Speaker: Rufus Isaacs will discuss late-season insect management. More

  2. Major Oak Diseases and Their Control.

    E-Print Network [OSTI]

    Johnson, Jerral D.; Appel, David N.

    1984-01-01T23:59:59.000Z

    Station, Texas (Blaok Page bl-?OriglulBidletial? / . , ,;..,' ,- ; ~ ~ " trees of Texas and are also... important components of forests and rangelands. They are normally long-lived, possess the ability to withstand adverse weather and have been considered disease resistant. During the drought in the mid 1950s large expanses of oak trees began dying...

  3. DISEASE-SPECIFIC PROBABILISTIC BRAIN ATLASES

    E-Print Network [OSTI]

    Thompson, Paul

    algorithms for knowledge-based image analysis, automated image labeling, tissue classification, data mining School of Medicine, Los Angeles, CA 2 Alzheimer's Disease Center, UCLA School of Medicine, Los Angeles Westwood Plaza, Los Angeles, CA 90095-1769 Phone: (310) 206-2101 Fax: (310) 206-5518 E-mail: thompson

  4. Osteoporosis Osteoporosis is a disease character-

    E-Print Network [OSTI]

    SS-167-R05 Osteoporosis Osteoporosis is a disease character- ized by structural deterioration of bone tissue, leading to fragile bones and low bone mass. Osteoporosis can weaken bones and cause them" because bone loss occurs with- out symptoms. Many people may not know that they have osteoporosis until

  5. INFLAMMATORY BOWEL DISEASE: THE INSIDE DISH

    E-Print Network [OSTI]

    Stanford, Kyle

    to be aware of advances that can improve quality of life. UC Irvine Healthcare's H.H. Chao Comprehensive Center at UC Irvine Medical Center. Patients with Crohn's disease or ulcerative colitis benefit from 101 Jocelyne Miller, MD Medication Fix ­ Overview of Medical Treatments Nimisha K. Parekh, MD, MPH

  6. DISEASES OF AQUATIC ORGANISMS Dis Aquat Org

    E-Print Network [OSTI]

    Nizet, Victor

    ), and hybrid striped bass (Evans et al. 2000). Clinical symptoms of S. iniae infection in fish include loss from the freshwater dolphin Inia geoffrensis (Pier & Madin 1976), S. iniae infects a wide range of fish infection in humans who have handled diseased fish (Weinstein et al. 1997). Despite the need for novel

  7. Motor Control Abnormalities in Parkinson's Disease

    E-Print Network [OSTI]

    Motor Control Abnormalities in Parkinson's Disease Pietro Mazzoni, Britne Shabbott, and Juan Camilo Corte´s Motor Performance Laboratory, The Neurological Institute, Columbia University, New York, New. Motor symptoms can also be described in terms of motor control, a level of description that explains how

  8. Evaluation of AFBC co-firing of coal and hospital wastes. Technical report, January 1989--August 1990

    SciTech Connect (OSTI)

    Not Available

    1991-02-01T23:59:59.000Z

    The purpose of this program is to expand the use of coal by utilizing CFB (circulating fluidized bed) technology to provide an environmentally safe method for disposing of waste materials. Hospitals are currently experiencing a waste management crisis. In many instances, they are no longer permitted to burn pathological and infectious wastes in incinerators. Older hospital incinerators are not capable of maintaining the stable temperatures and residence times necessary in order to completely destroy toxic substances before release into the atmosphere. In addition, the number of available landfills which can safely handle these substances is decreasing each year. The purpose of this project is to conduct necessary research investigating whether the combustion of the hospital wastes in a coal-fired circulating fluidized bed boiler will effectively destroy dioxins and other hazardous substances before release into the atmosphere. If this is proven feasible, in light of the quantity of hospital wastes generated each year, it would create a new market for coal -- possibly 50 million tons/year.

  9. Disease Prediction Models and Operational Readiness

    SciTech Connect (OSTI)

    Corley, Courtney D.; Pullum, Laura L.; Hartley, David M.; Benedum, Corey M.; Noonan, Christine F.; Rabinowitz, Peter M.; Lancaster, Mary J.

    2014-03-19T23:59:59.000Z

    INTRODUCTION: The objective of this manuscript is to present a systematic review of biosurveillance models that operate on select agents and can forecast the occurrence of a disease event. One of the primary goals of this research was to characterize the viability of biosurveillance models to provide operationally relevant information for decision makers to identify areas for future research. Two critical characteristics differentiate this work from other infectious disease modeling reviews. First, we reviewed models that attempted to predict the disease event, not merely its transmission dynamics. Second, we considered models involving pathogens of concern as determined by the US National Select Agent Registry (as of June 2011). Methods: We searched dozens of commercial and government databases and harvested Google search results for eligible models utilizing terms and phrases provided by public health analysts relating to biosurveillance, remote sensing, risk assessments, spatial epidemiology, and ecological niche-modeling, The publication date of search results returned are bound by the dates of coverage of each database and the date in which the search was performed, however all searching was completed by December 31, 2010. This returned 13,767 webpages and 12,152 citations. After de-duplication and removal of extraneous material, a core collection of 6,503 items was established and these publications along with their abstracts are presented in a semantic wiki at http://BioCat.pnnl.gov. Next, PNNL’s IN-SPIRE visual analytics software was used to cross-correlate these publications with the definition for a biosurveillance model resulting in the selection of 54 documents that matched the criteria resulting Ten of these documents, However, dealt purely with disease spread models, inactivation of bacteria, or the modeling of human immune system responses to pathogens rather than predicting disease events. As a result, we systematically reviewed 44 papers and the results are presented in this analysis.

  10. Elevated expression of ERK 2 in human tumor cells chronically treated with PD98059

    SciTech Connect (OSTI)

    Kanda, Shigeru [Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, Nagasaki (Japan)]. E-mail: skanda-jua@umin.net; Kanetake, Hiroshi [Department of Urology, Nagasaki University Graduate School of Biomedical Science, Nagasaki (Japan); Miyata, Yasuyoshi [Department of Urology, Nagasaki University Graduate School of Biomedical Science, Nagasaki (Japan)

    2006-07-14T23:59:59.000Z

    We examined the effect of chronic exposure of tumor cells to a mitogen-activated protein kinase/extracellular signal-regulated kinases (ERK) kinase inhibitor, PD98059, on cell proliferation was investigated. Human renal carcinoma cells (ACHN) and prostatic carcinoma cells (DU145) were cultured in the presence of PD98059 for more than 4 weeks (denoted ACHN (PD) cells and DU145 (PD) cells, respectively) and proliferation and signal transduction pathways were examined. PD98059 significantly inhibited the proliferation of parental cells. However, PD98059 failed to inhibit proliferation of ACHN (PD) and DU145 (PD) cells significantly. Expression of ERK 1 and 2 was elevated in these cells. These phenotypes were reversible. Downregulation of ERK 2, but not ERK 1, by small interfering RNA significantly inhibited the proliferation of ACHN (PD) and DU145 (PD) cells. Taken together, chronic exposure of tumor cells to PD98059 induced elevated expression of ERK 2, which was associated with decreased sensitivity of cellular proliferation to PD98059.

  11. Effect of chronic oil pollution on salt-marsh nitrogen fixation (acetylene redution). [Spartina alterniflora

    SciTech Connect (OSTI)

    Thomson, A.D.; Webb, K.L.

    1984-03-01T23:59:59.000Z

    Annual acetylene reduction rates associated with intertidal communities in a chronically oil polluted Virgina salt marsh were compared to rates measured in an undisturbed marsh. Chronic oil treatment resulted in visible damage to the higher plants of the Spartina alterniflora zones; however, vegetation-associated acetylene reduction was not different from the untreated control. Sediment rates generally were affected little by oil application, except during the summer when rates in the median tidal elevation zones were considerably higher than those of the control. Acetylene reduction occurred in all transects, each of which extended from upper mudflat to the Spartina patens zone. Intertidal sediment acetylene reduction was patchy, both spatially and seasonally. Estimated rates were greatest near the surface; free-living bacterial N/sub 2/ fixation activity averaged 2.23 mg N per m/sup 2/ per d (range = undetectable to 365 mg N per m/sup 2/ per d) in the untreated and 3.17 mg N per m/sup 2/ per d (range = undetectable to 564 mg N per m/sup 2/ per d) in the oil-treated marsh during the year. Vegetation-associated N/sub 2/ fixation activity yielded highest overall mean rates (156 mg N per M/sub 2/ per d). The seasonal pattern of sediment and vegetation-associated fixation may be controlled by temperature and availability of oxidizable substrates. 39 references, 2 figures, 5 tables.

  12. Activation of retinal tyrosine hydroxylase: tolerance induced by chronic treatment with haloperidol does not modify response to light

    SciTech Connect (OSTI)

    Cohen, J.; Neff, N.H.

    1982-05-01T23:59:59.000Z

    A single dose of haloperidol administered to rats in the dark increases the activity of retinal tyrosine hydroxylase. The ability of haloperidol to activate the enzyme is diminished 24 hr after terminating 22 to 30 days of treatment with haloperidol. The retinal enzyme is also tolerant to activation by treatment with chlorpromazine. In contrast, exposure of the animals to light activates the enzyme to the same extent in chronic haloperidol-treated and control animals. Thus, chronic haloperidol treatment does not modify the ability of the retinal enzyme system to respond to the physiological stimulus, light. Apparently, activation of retinol tyrosine hydroxylase by haloperidol and light occurs by independent mechanisms.

  13. What You Should Know About Plant Diseases.

    E-Print Network [OSTI]

    Horne, C. Wendell; Smith, Harlan E.

    1962-01-01T23:59:59.000Z

    . From 1845 to 1860, plant disease caused a disaster in Irelantl. Late blight struck the potato- yrowing region and turned the fields into a black- ened, rotting mass. A million people diet1 because I the potato crop failed; numerous families.... OTHER CONDITIONS WHICH MAY CAUSE PLANT IN JURY 1. Drying winds 2. Excessive light 3. Excessive lime in the soil 4. Over-use of commercial fertilizer 5. Gas injury PARASITIC OR SAPROPHYTIC PLANTS MISTLETOE-Mistletoe is a parasitic flowering plant...

  14. Soil Fumigation for Plant Disease Control.

    E-Print Network [OSTI]

    Young, P. A. (Paul Allen); Godfrey, G. H. (George Harold)

    1943-01-01T23:59:59.000Z

    satisfactory results were secured wikh xylene, ethylene dichloride, sodium cyanide and formaldehyde. Paper impregnated wit11 hoof-and-horn glue, casein glue, or vegetttble paste, and adequately sealed at the edges, was most satisfactory for con- fining... of the fumigants were effec- tive when the funligants were tightly confined in the soil. Soil fumigation boxes, made gas-tight by glueing the boards together and sealing the cover, were very effective for confining fumeants to kill plant-disease fungi and other...

  15. Biomonitoring of organochlorines in women with benign and malignant breast disease

    SciTech Connect (OSTI)

    Siddiqui, M.K.J. [Analytical Toxicology, Industrial Toxicology Research Centre, P.O. Box No. 80, M.G. Marg, Lucknow 226 001 (India)]. E-mail: mkjs@rediffmail.com; Anand, M. [Analytical Toxicology, Industrial Toxicology Research Centre, P.O. Box No. 80, M.G. Marg, Lucknow 226 001 (India); Mehrotra, P.K. [Sir Ganga Ram Hospital, New Delhi (India); Sarangi, R. [Sir Ganga Ram Hospital, New Delhi (India); Mathur, N. [Analytical Toxicology, Industrial Toxicology Research Centre, P.O. Box No. 80, M.G. Marg, Lucknow 226 001 (India)

    2005-06-01T23:59:59.000Z

    Established risk factors for breast cancer explain breast cancer risk only partially. Organochlorines are considered to be a possible cause for hormone-dependent cancers. A hospital-based case-control study, the first from India, was conducted among 50 women undergoing surgery for breast disease to examine the association between organochlorine exposure and breast cancer risk. Blood, tumor, and surrounding adipose tissue of the breast were collected from the subjects with benign (control) and malignant breast (study) lesions and analyzed to determine organochlorine insecticides using a gas-liquid chromatograph equipped with an electron capture detector. The {alpha}, {beta}, {gamma}, and {delta} isomers of hexachlorocyclohexane (HCH), p,p'-dichlorodiphenyltrichloroethane (DDT), o,p'-DDT, p,p-dichlorodiphenyldichloroethylene, and p,p'-dichlorodiphenyldichloroethane were frequently detected in three specimens. Total HCH and total DDT levels were higher in the blood of the study group (25 cases) than in those of the controls (25 cases) with only {gamma}-HCH being significantly different (P0.05). However, both total HCH and total DDT were higher in the tumor tissues of the controls than in those of the study group; {gamma}-HCH was significantly different (P0.05). The level of total HCH ({alpha}-HCH was significantly different, P0.05) was higher in the breast adipose tissue of the study group, whereas total DDT was higher in the breast adipose tissue of the control group. The distribution of known confounders of breast cancer including age, body mass index, age at menarche and menopause, duration of breast feeding, and family history related to breast disease did not differ significantly between benign and malignant groups. This pilot study with limited statistical power does not support a positive association between exposure to organochlorines and risk of breast cancer but paves the way for a larger Indian study with greater statistical power encompassing different regions of the country to enable statistically sound conclusions.

  16. Characterization of a Drosophila model of Huntington's disease

    E-Print Network [OSTI]

    Lee, Wyan-Ching Mimi

    2006-01-01T23:59:59.000Z

    Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...

  17. Women and Heart Disease: Neglected Directions for Future Research

    E-Print Network [OSTI]

    Barrett-Connor, Elizabeth

    2009-01-01T23:59:59.000Z

    009-9110-0 Women and Heart Disease: Neglected Directions forage 65, women have less heart disease than men. For many1980s showed a lower risk of heart attacks in postmenopausal

  18. Bleb Point: Mimicker of Pneumothorax in Bullous Lung Disease

    E-Print Network [OSTI]

    Gelabert, Christopher; Nelson, Mathew

    2015-01-01T23:59:59.000Z

    G, Biderman P, et al. “The lung point”: an REFERENCESof cystic and bullous lung disease. Chest Surg Clin N Am.S, Kaiser LR. Giant bullous lung disease: chest radiography

  19. alberta kidney disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for nearly 44 percent of new cases.1 Even when diabetes is controlled, the disease can lead to CKD Baker, Chris I. 2 Kidney Dysplasia National Kidney and Urologic Diseases...

  20. asbestos induced diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease in a patient may be a marker for disease in household contacts. Patients with family members heavily exposed to asbestos should be strongly encouraged to quit smoking in...

  1. animal virus diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  2. animal disease models: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Physics Websites Summary: Modelling the spread of foot-and-mouth disease virus F Moutou B Durand CNEVA, Laboratoire Central-and-mouth disease is an economically important viral...

  3. An indoor radon survey of the X-ray rooms of Mexico City hospitals

    SciTech Connect (OSTI)

    Juarez, Faustino [Facultad de Ciencias, Universidad Autonoma del Estado de Mexico, Instituto Literario No. 100. Estado de Mexico, 50000, Mexico. Instituto de Geofisica, Universidad Nacional Autonoma de Mexico, Circuito (Mexico); Reyes, Pedro G. [Facultad de Ciencias, Universidad Autonoma del Estado de Mexico, Instituto Literario No. 100. Estado de Mexico, 50000 (Mexico); Espinosa, Guillermo [Instituto de Fisica, Universidad Nacional Autonoma de Mexico, Circuito Exterior Ciudad Universitaria, Mexico D.F. Cp.04510 (Mexico)

    2013-07-03T23:59:59.000Z

    This paper presents the results of measurements of indoor radon concentrations in the X-ray rooms of a selection of hospitals in the metropolitan area of Mexico City. The metropolitan area of Mexico City is Mexico's largest metropolitan area by population; the number of patients requiring the use of X-rays is also the highest. An understanding of indoor radon concentrations in X-ray rooms is necessary for the estimation of the radiological risk to which patients, radiologists and medical technicians are exposed. The indoor radon concentrations were monitored for a period of six months using nuclear track detectors (NTD) consisting of a closed-end cup system with CR-39 (Lantrack Registered-Sign ) polycarbonate as detector material. The indoor radon concentrations were found to be between 75 and 170 Bq m{sup -3}, below the USEPA-recommended indoor radon action level for working places of 400 Bq m{sup -3}. It is hoped that the results of this study will contribute to the establishment of recommended action levels by the Mexican regulatory authorities responsible for nuclear safety.

  4. Risk of Chronic Oral Anticoagulation Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction - Retrospective Cross-Sectional Study

    E-Print Network [OSTI]

    Vanga, Subba Reddy

    2013-12-31T23:59:59.000Z

    i Risk of Chronic Oral Anticoagulation Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction – Retrospective Cross-Sectional Study BY Copyright 2013 Subba Reddy Vanga... The Thesis Committee for Subba Reddy Vanga certifies that this is the approved version of the following thesis: Risk of Chronic Oral Anticoagulation Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST Elevation...

  5. Should we expect population thresholds for wildlife disease?

    E-Print Network [OSTI]

    Getz, Wayne M.

    of Zoology and Entomology, University of Pretoria, 0002 South Africa 6 Energy and Resources Group, University , Adam B. Smith6 and Andrea Swei4 1 Department of Environmental Science, Policy and Management of infectious disease are core concepts of disease ecology and underlie disease control policies based

  6. Understanding Equine Strangles: Signs of Disease, Management and Prevention1

    E-Print Network [OSTI]

    Watson, Craig A.

    in 1251. The infection is highly contagious in horse populations and can recur on farms with previous outbreaks of the disease. It is one of the most commonly diagnosed contagious diseases of the horse signs of infection. Complications of Disease Fortunately, although strangles is highly contagious

  7. A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN

    E-Print Network [OSTI]

    A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN BY R. R. RUCKER, W. J. WHIPPLE, J. R A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN By R. R. Rucker, W. J. Whipple, J. R. Parvin and C. A #12;A CONTAGIOUS DISEASE OF SALMON, POSSIBLY OF VIRUS ORIGIN By R. R. Rucker,! Fishery Research

  8. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  9. Sals-Wuillemin, E., Morlot, R., Fontaine, A., Pullin, W., Galand, Ch., Talon, D., Minary-Dohen, P. (2011) Evolution of Nurses' Social Representation of hospital Hygiene : from training to practice, Revue Europenne

    E-Print Network [OSTI]

    Boyer, Edmond

    2011-01-01T23:59:59.000Z

    . (2011) Evolution of Nurses' Social Representation of hospital Hygiene : from training to practice, Revue Européenne de Psychologie Appliquée, 61, 51-63 1 Running Head: SOCIAL REPRESENTATIONS OF HOSPITAL HYGIENE EVOLUTION OF NURSES' SOCIAL REPRESENTATIONS OF HOSPITAL HYGIENE: FROM TRAINING TO PRACTICE E. Salès

  10. Neurobiology of Disease Neuroinflammation Alters the Hippocampal Pattern of

    E-Print Network [OSTI]

    Wenk, Gary

    chronically infused with lipopolysaccharide (LPS) (0.25 g/h) into the fourth ventricle for 28 d. On day 29 and CA3 regions of LPS-infused rats, Arc and OX-6 (specific for major histocompatibility complex class II immunoreactivity) and elevated exploration-induced Arc expression compared with control-infused rats. In contrast

  11. New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc

    E-Print Network [OSTI]

    Corona, C; Pensalfini, A; Frazzini, V; Sensi, S L

    2011-01-01T23:59:59.000Z

    39;s disease: brain deregulation of calcium and zinc [39;s disease: brain deregulation of calcium and zinc39;s disease: brain deregulation of calcium and zinc Gotz

  12. Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    2009-01-01T23:59:59.000Z

    predictors of coronary heart disease among women. Americanon the risk for coronary heart disease even stronger thanx Smoking and Ischemic Heart Disease Disparities Between

  13. ANTI-INFLAMMATORY PROPERTY OF THE CANNABINOID AGONIST WIN-55212-2 IN A RODENT MODEL OF CHRONIC BRAIN

    E-Print Network [OSTI]

    Wenk, Gary

    ANTI-INFLAMMATORY PROPERTY OF THE CANNABINOID AGONIST WIN-55212-2 IN A RODENT MODEL OF CHRONIC-methanone mesylate (WIN-55212- 2), on microglial activation and spatial memory performance, using a well/h for 3 weeks) into the fourth ventricle of young rats. WIN-55212-2 (0.5 or 1.0 mg/kg/day, i

  14. Spatial and temporal variations in indoor environmental conditions, human occupancy, and operational characteristics in a new hospital building

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ramos, Tiffanie; Dedesko, Sandra; Siegel, Jeffrey A.; Gilbert, Jack A.; Stephens, Brent

    2015-03-02T23:59:59.000Z

    The dynamics of indoor environmental conditions, human occupancy, and operational characteristics of buildings influence human comfort and indoor environmental quality, including the survival and progression of microbial communities. A suite of continuous, long-term environmental and operational parameters were measured in ten patient rooms and two nurse stations in a new hospital building in Chicago, IL to characterize the indoor environment in which microbial samples were taken for the Hospital Microbiome Project. Measurements included environmental conditions (indoor dry-bulb temperature, relative humidity, humidity ratio, and illuminance) in the patient rooms and nurse stations; differential pressure between the patient rooms and hallways; surrogatemore »measures for human occupancy and activity in the patient rooms using both indoor air CO? concentrations and infrared doorway beam-break counters; and outdoor air fractions in the heating, ventilating, and air-conditioning systems serving the sampled spaces. Measurements were made at 5-minute intervals over consecutive days for nearly one year, providing a total of ~8×10? data points. Indoor temperature, illuminance, and human occupancy/activity were all weakly correlated between rooms, while relative humidity, humidity ratio, and outdoor air fractions showed strong temporal (seasonal) patterns and strong spatial correlations between rooms. Differential pressure measurements confirmed that all patient rooms were operated at neutral pressure. The patient rooms averaged about 100 combined entrances and exits per day, which suggests they were relatively lightly occupied compared to higher traffic environments (e.g., retail buildings) and more similar to lower traffic office environments. There were also clear differences in several environmental parameters before and after the hospital was occupied with patients and staff. Characterizing and understanding factors that influence these building dynamics is vital for hospital environments, where they can impact patient health and the survival and spread of healthcare associated infections.« less

  15. A medium-rise 1970’s maternity hospital in the east of England: resilience and adaptation to climate change

    E-Print Network [OSTI]

    Short, C. Alan; Giridharan, Renganathan; Lomas, Kevin J.

    2014-01-01T23:59:59.000Z

    .Thomas’s tower on the Thames and Oxford’s John Radcliffe Hospital. The essential framed, glazed treatment is consistent. Writing particularly of F.R.S.Yorke, YRM’S founder and an important publicist for modern architecture, Worsley wrote,” it was the rise... a huge barrier to achieving adaptation of the public non-domestic building stock, unfortunate given that the NHS Retained Estate would seem to be a particularly promising place to implement a public sector adaptation scheme...

  16. Magnetic Resonance Imaging-Guided Osseous Biopsy in Children With Chronic Recurrent Multifocal Osteomyelitis

    SciTech Connect (OSTI)

    Fritz, Jan, E-mail: jfritz9@jhmi.edu [Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science (United States); Tzaribachev, Nikolay [University Children's Hospital, Eberhard-Karls-University Tuebingen, Division of Pediatric Rheumatology (Germany); Thomas, Christoph [Eberhard-Karls-University Tuebingen, Department of Diagnostic and Interventional Radiology (Germany); Wehrmann, Manfred [Eberhard-Karls-University Tuebingen, Department of Pathology (Germany); Horger, Marius S. [Eberhard-Karls-University Tuebingen, Department of Diagnostic and Interventional Radiology (Germany); Carrino, John A. [Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science (United States); Koenig, Claudius W.; Pereira, Philippe L. [Eberhard-Karls-University Tuebingen, Department of Diagnostic and Interventional Radiology (Germany)

    2012-02-15T23:59:59.000Z

    Purpose: To report the safety and diagnostic performance of magnetic resonance (MRI)-guided core biopsy of osseous lesions in children with chronic recurrent multifocal osteomyelitis (CRMO) that were visible on MRI but were occult on radiography and computed tomography (CT). Materials and Methods: A retrospective analysis of MRI-guided osseous biopsy performed in seven children (four girls and three boys; mean age 13 years (range 11 to 14) with CRMO was performed. Indication for using MRI guidance was visibility of lesions by MRI only. MRI-guided procedures were performed with 0.2-Tesla (Magnetom Concerto; Siemens, Erlangen, Germany; n = 5) or 1.5-T (Magnetom Espree; Siemens; n = 2) open MRI systems. Core needle biopsy was obtained using an MRI-compatible 4-mm drill system. Conscious sedation or general anesthesia was used. Parameters evaluated were lesion visibility, technical success, procedure time, complications and microbiology, cytology, and histopathology findings. Results: Seven of seven (100%) targeted lesions were successfully visualized and sampled. All obtained specimens were sufficient for histopathological analysis. Length of time of the procedures was 77 min (range 64 to 107). No complications occurred. Histopathology showed no evidence of malignancy, which was confirmed at mean follow-up of 50 months (range 28 to 78). Chronic nonspecific inflammation characteristic for CRMO was present in four of seven (58%) patients, and edema with no inflammatory cells was found in three of seven (42%) patients. There was no evidence of infection in any patient. Conclusion: MRI-guided osseous biopsy is a safe and accurate technique for the diagnosis of pediatric CRMO lesions that are visible on MRI only.

  17. Visualizing Brain Metals in Health and Disease

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron SpinPrincetonUsing Maps1 -Visualizing Brain Metals in Health and Disease

  18. Genetic Contributions to Infectious Disease Risk Infectious disease in cattle production

    E-Print Network [OSTI]

    Life Research, Texas A&M University, West· Texas A&M University, Texas Tech University, and USDA associated with disease resistance. Researchers at Texas AgriLife Research are well positioned to address collaborations including scientists in the College of Veterinary Medicine and Bio- medical Sciences at Texas A

  19. Developing an indicator for the chronic health impact of traffic-related pollutant emissions

    SciTech Connect (OSTI)

    Lepicier, Veronique [IFSTTAR, Laboratoire Transport et Environnement, 25, av. F. Mitterrand, 69675 Bron Cedex (France); Chiron, Mireille [IFSTTAR, UMRESTTE, 25, av. F. Mitterrand, 69675 Bron Cedex (France); Joumard, Robert, E-mail: robert.joumard@laposte.net [IFSTTAR, Laboratoire Transport et Environnement, 25, av. F. Mitterrand, 69675 Bron Cedex (France)

    2013-01-15T23:59:59.000Z

    The goal of this study is to develop an emission based indicator for the health impact of the air pollution caused by traffic. This indicator must make it possible to compare different situations, for example different Urban Travel Plans, or technical innovations. Our work is based on a literature survey of methods for evaluating health impacts and, more particularly, those which relate to the atmospheric pollution caused by transport. We then define a health impact indicator based on the traffic emissions, named IISCEP for Chronic health impact indicator of pollutant emission. Here health is understood in a restricted meaning, excluding well-being. Only primary pollutants can be considered, as the inputs are emission data and an indicator must be simple. The indicator is calculated as the sum of each pollutant emission multiplied by a dispersion and exposition factor and a substance specific toxicity factor taking account of the severity. Last, two examples are shown using the IISCEP: comparison between petrol and diesel vehicles, and Nantes urban district in 2008 vs 2002. Even if it could still be improved, IISCEP is a straightforward indicator which can be used to gauge the chronic effects of inhaling primary pollutants. It can only be used in comparisons, between different scenarios or different technologies. The quality of the emissions data and the choice of the pollutants that are considered are the two essential factors that determine its validity and reliability. - Highlights: Black-Right-Pointing-Pointer The goal of the study is to develop an emission based indicator for the health impact of the air pollution caused by traffic. Black-Right-Pointing-Pointer It is based on a literature survey of methods for evaluating health impacts related to the atmospheric pollution. Black-Right-Pointing-Pointer We define a composite indicator based on the traffic emissions and on local data as dispersion conditions and population. Black-Right-Pointing-Pointer The indicator is a combination of pollutant emission, dispersion, exposition factor, and substance specific toxicity factor. Black-Right-Pointing-Pointer Applications are global (e.g. comparison of vehicle technologies) or local (e.g. comparison of populations or areas).

  20. Automated diagnostic kiosk for diagnosing diseases

    DOE Patents [OSTI]

    Regan, John Frederick; Birch, James Michael

    2014-02-11T23:59:59.000Z

    An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

  1. Optical detection dental disease using polarized light

    DOE Patents [OSTI]

    Everett, Matthew J. (Livermore, CA); Colston, Jr., Billy W. (Livermore, CA); Sathyam, Ujwal S. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Fried, Daniel (San Francisco, CA)

    2003-01-01T23:59:59.000Z

    A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.

  2. Thiacetarsamide therapy of heartworm disease in cats: a pharmacokinetic study

    E-Print Network [OSTI]

    Turner, Janet Lynn

    1988-01-01T23:59:59.000Z

    . Coughing and exerci se intolerance are common clinical signs. Coughing may be related to the severe pulmonary arterial disease or may be due to pneumonitis induced by the heartworm ~nfection. Severe cases of dirofilariasis may have hemoptysis... intermittent coughing and dyspnea, as well as anorexia and vomiting. Necropsies of cats with heartworm disease usually demonstrate a low worm burden. ' Cardiomegaly is less common in cats than in 23, 30-34 dogs with heartworm disease. Pulmonary arterial...

  3. avium complex disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Characterizing SNP-Disease Associations Using Bayesian Networks University of Kansas - KU ScholarWorks Summary: of computational methods in epistatic interaction...

  4. aleutian mink disease virus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cause diseases with long incubation periods, insidious onsets, and slowly progressive courses (1). The members of the virus group include visna virus of sheep, caprine...

  5. aleutian disease virus: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cause diseases with long incubation periods, insidious onsets, and slowly progressive courses (1). The members of the virus group include visna virus of sheep, caprine...

  6. asbestos-related pleuropulmonary diseases: Topics by E-print...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

  7. adnexal diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

  8. anus diseases: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases Ulcer treatment has been revolutionized by recently discovered knowledge about Helicobacter pylori, a bacterium commonly found in the human gastrointestinal tract. These...

  9. assessing disease activity: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    marked geographic clustering, and lack of reliable data on incidence, duration, and impact of the various disease syndromes. Non-health effects such as impoverishment,...

  10. Genomics of emerging infectious disease: A PLoS collection.

    E-Print Network [OSTI]

    Eisen, Jonathan A; MacCallum, Catriona J

    2009-01-01T23:59:59.000Z

    Origins and evolutionary genomics of the 2009 swine-originan Infectious Diseases Genomics Project predict and preventRavel J (2009) The role of genomics in the identification,

  11. Recombinant herpes simplex virus useful for treating neoplastic disease

    DOE Patents [OSTI]

    Whitley, Richard J.; Roizman, Bernard

    2010-06-29T23:59:59.000Z

    Recombinant herpes simplex viruses comprising DNA encoding cytokines and methods for treating neoplastic diseases using the inventive recombinant viruses are disclosed.

  12. Cloning of the human TASK-2 (KCNK5) promoter and its regulation by chronic hypoxia

    SciTech Connect (OSTI)

    Brazier, Stephen P. [School of Biosciences, Museum Avenue, Cardiff University, Cardiff CF10 3US (United Kingdom); Mason, Helen S. [School of Biosciences, Museum Avenue, Cardiff University, Cardiff CF10 3US (United Kingdom); Bateson, Alan N. [School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT (United Kingdom); Kemp, Paul J. [School of Biosciences, Museum Avenue, Cardiff University, Cardiff CF10 3US (United Kingdom)]. E-mail: Kemp@cf.ac.uk

    2005-11-04T23:59:59.000Z

    The tandem P domain potassium channel family includes five members of the acid-sensing subfamily, TASK. TASK channels are active at resting potential and are inhibited by extracellular protons, suggesting they function as acid sensors and control excitability/ion homeostasis. Indeed, TASK-2 (KCNK5) has been shown to control excitability, volume regulation, bicarbonate handling, and apoptosis in a variety of tissues. With such diverse functions being ascribed to TASK-2, it is important to understand long-term as well as short-term regulation of this important channel. Thus, we have cloned the TASK-2 promoter, demonstrated that its transcriptional activity is dependent upon pO{sub 2}, shown that deletion of overlapping consensus binding sites for NF-{kappa}B/Elk-1 ablates this O{sub 2} sensitivity, and proved that Elk-1 binds preferentially to this site. Furthermore, the consequences of chronic hypoxia on natively expressed TASK-2 are decreased steady-state mRNA and cell depolarization showing that TASK-2 contributes to the excitability of this important lung cell type.

  13. Spred2 is involved in imatinib-induced cytotoxicity in chronic myeloid leukemia cells

    SciTech Connect (OSTI)

    Liu, Xiao-Yun; Yang, Yue-Feng; Wu, Chu-Tse; Xiao, Feng-Jun; Zhang, Qun-Wei [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Ma, Xiao-Ni [Lanzhou University of Technology, Lanzhou 730050 (China)] [Lanzhou University of Technology, Lanzhou 730050 (China); Li, Qing-Fang; Yan, Jun [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Wang, Hua, E-mail: wanghualjh@gmail.com [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Wang, Li-Sheng, E-mail: wangls@nic.bmi.ac.cn [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)

    2010-03-19T23:59:59.000Z

    Spreds, a recently established class of negative regulators of the Ras-ERK (extracellular signal-regulated kinase) pathway, are involved in hematogenesises, allergic disorders and tumourigenesis. However, their role in hematologic neoplasms is largely unknown. Possible effects of Spreds on other signal pathways closely related to Ras-ERK have been poorly investigated. In this study, we investigated the in vitro effects of Spred2 on chronic myeloid leukemia (CML) cells. In addition to inhibiting the well-established Ras-ERK cascade, adenovirus-mediated Spred2 over-expression inhibits constitutive and stem cell factor (SCF)-stimulated sphingosine kinase-1 (SPHK1) and Mcl-1 expression, as well as inhibiting proliferation and inducing apoptosis in CML cells. In K562 cells and primary CML cells, imatinib induces endogenous Spred2 expression. Spred2 silencing by stable RNA interference partly protects K562 cells against imatinib-induced apoptosis. Together, these data implicate Spred2 in imatinib-induced cytotoxicity in CML cells, possibly by inhibiting the Ras-ERK cascade and the pro-survival signaling molecules SPHK1 and Mcl-1. These findings reveal potential targets for selective therapy of CML.

  14. INTRACELLULAR COPPER ACCUMULATION ENHANCES THE GROWTH OF KINEOCOCCUS RADIOTOLERANS DURING CHRONIC IRRADIATION

    SciTech Connect (OSTI)

    Bagwell, C; Charles Milliken, C

    2007-07-24T23:59:59.000Z

    The actinobacteria Kineococcus radiotolerans is highly resistant to ionizing radiation, desiccation, and oxidative stress; though the underlying biochemical mechanisms are unknown. The purpose of this study was to explore a possible linkage between the uptake of transition metals and extreme resistance to ionizing radiation and oxidative stress. The effects of 6 different divalent cationic metals on growth were examined in the absence of ionizing radiation. None of the metals tested were stimulatory, though cobalt was inhibitory to growth. In contrast, copper supplementation dramatically increased cell growth during chronic irradiation. K. radiotolerans exhibited specific uptake and intracellular accumulation of copper compared to only a weak response to both iron and manganese supplementation. Copper accumulation sensitized cells to hydrogen peroxide. Acute irradiation induced DNA damage was similar between the copper-loaded culture as the age-synchronized no copper control culture, though low molecular weight DNA was more persistent during post-irradiation recovery in the Cu-loaded culture. Still, the estimated times for genome restoration differed by only 1 hr between treatments. While we cannot discount the possibility that copper fulfills an unexpectedly important biochemical role in a radioactive environment; K. radiotolerans has a high capacity for intracellular copper sequestration, and presumably efficiently coordinated oxidative stress defenses and detoxification systems, which confers cross-protection from the damaging affects ionizing radiation.

  15. {sup 137}Cs elimination by chronically-contaminated largemouth bass (Micropterus salmoides)

    SciTech Connect (OSTI)

    Peters, E.L.; Newman, M.C. [Savannah River Ecology Lab., Aiken, SC (United States)

    1999-03-01T23:59:59.000Z

    The temperature-dependent {sup 137}Cs biological half-times (T{sub b}) of lifetime-exposed largemouth bass (Micropterus salmoides) from a nuclear cooling reservoir at the US Department of Energy`s Savannah River Site were calculated from whole-body measurements of live fish and compared with literature records for acutely and chronically-contaminated fish. The T{sub b}`s of the bass averaged 322 d, 225 d, and 140 d at 15, 20, and 26 C, respectively. These mean T{sub b}`s were 1.7 to 2.5 times longer than would be expected for acutely contaminated fish, and 1.2 to 1.8 times longer than those predicted for fish at steady-state with their environment according to recent models. This slower elimination did not appear to result from slower elimination from skeletal muscle compared with other soft tissues, in that the muscle to whole-body {sup 137}Cs concentration ratios after the elimination period were similar to those of freshly-caught bass. Their results suggested that elimination rates estimated from the terminal elimination components of acutely-dosed fish may not reflect the elimination rates of fish exposed to contaminants throughout their lifetime, even when care is taken to allow sufficient time for absorption of the dose.

  16. Using “warm handoffs” to link hospitalized smokers with tobacco treatment after discharge: study protocol of a randomized controlled trial

    E-Print Network [OSTI]

    Faseru, Babalola; Mussulman, Laura M.; Ellerbeck, Edward F.; Shireman, Theresa I.; Hunt, Jamie J.; Carlini, Beatriz H.; Preacher, Kristopher J.; Ayars, Candace L.; Cook, David J.; Richter, Kimber P.

    2012-08-01T23:59:59.000Z

    post-randomization Handoff Figure 1 Overview and study design of EQUIP – a randomized controlled trial.will collect 1-, 6-, and 12-month follow-up data. Outcome measures and analyses include 30-day point prevalence abstinence at 6 months, biochemically...:10.1186/1745-6215-13-127 Cite this article as: Richter et al.: Using “warm handoffs” to link hospitalized smokers with tobacco treatment after discharge: study protocol of a randomized controlled trial. Trials 2012 13:127. Richter et al. Trials 2012...

  17. Examining the effects of remote monitoring systems on activation, self-care, and quality of life in older patients with chronic heart failure

    E-Print Network [OSTI]

    2015-01-01T23:59:59.000Z

    the primary component of chronic heart failure management inCochrane review. Eur J Heart Fail. 2011;13(9):1028Y1040.MLHFQ, Minnesota Living With Heart Failure Questionnaire;

  18. The flexDrive: an ultra-light implant for optical control and highly parallel chronic recording of neuronal ensembles in freely moving mice

    E-Print Network [OSTI]

    Voigts, Jakob

    Electrophysiological recordings from ensembles of neurons in behaving mice are a central tool in the study of neural circuits. Despite the widespread use of chronic electrophysiology, the precise positioning of recording ...

  19. An Analysis of Message Development, Delivery Strategies, Message Topics, Functional Consequences, and Social Responses of Requesting an Accommodation in the Workplace Due to a Chronic Health Condition

    E-Print Network [OSTI]

    Ellsworth, Erin L.

    2008-08-15T23:59:59.000Z

    By 2020, 157 million Americans will be living with a chronic health condition. Many will continue to work by requesting workplace accommodations such as changes to their work environment or work schedule. In interviews, ...

  20. Environmental effects of dredging: The use of population modeling to interpret chronic sublethal sediment bioassays. Technical notes

    SciTech Connect (OSTI)

    Bridges, T.S.; Dillon, T.M.

    1993-08-01T23:59:59.000Z

    This technical note provides a brief introduction to population modeling and describes the application and utility of such techniques for dredged material bioassays. The use of population modeling as a source of interpretive guidance for chronic sublethal dredged material bioassays is emphasized. Current laws and regulations governing the discharge of dredged material stress the importance of assessing the chronic (long-term) sublethal effects of dredging operations. Regulations implementing section 103 of the Marine Protection, Research and Sanctuaries Act (PL 92-532) state that, `Materials shall be deemed environmentally acceptable for ocean dumping only when . . . no significant undesirable effects will occur due either to chronic toxicity or to bioaccumulation........`. Similar language is used in regulations implementing section 404(b)(1) of the Clean Water Act (FL 92-500) which reads: `The permitting authority shall determine in writing the potential short-term or long-term effects of a proposed discharge of dredged or fill material on the physical, chemical, and biological components of the aquatic environment.........It also stipulates that tests may be required to provide information on the effect of the discharge material on communities or populations of organisms.`

  1. Upregulation of Cannabinoid Type 1 Receptors in Dopamine D2 Receptor Knockout Mice Is Reversed by Chronic Forced Ethanol Consumption

    SciTech Connect (OSTI)

    Thanos, P.K.; Wang, G.; Thanos, P.K.; Gopez, V.; Delis, F.; Michaelides, M.; Grand, D.K.; Wang, G.-J.; Kunos, G.; Volkow, N.D.

    2011-01-01T23:59:59.000Z

    The anatomical proximity of the cannabinoid type 1 (CNR1/CB1R) and the dopamine D2 receptors (DRD2), their ability to form CB1R-DRD2 heteromers, their opposing roles in locomotion, and their involvement in ethanol's reinforcing and addictive properties prompted us to study the levels and distribution of CB1R after chronic ethanol intake, in the presence and absence of DRD2. We monitored the drinking patterns and locomotor activity of Drd2+/+ and Drd2-/- mice consuming either water or a 20% (v/v) ethanol solution (forced ethanol intake) for 6 months and used the selective CB1 receptor antagonist [{sup 3}H]SR141716A to quantify CB1R levels in different brain regions with in vitro receptor autoradiography. We found that the lack of DRD2 leads to a marked upregulation (approximately 2-fold increase) of CB1R in the cerebral cortex, the caudate-putamen, and the nucleus accumbens, which was reversed by chronic ethanol intake. The results suggest that DRD2-mediated dopaminergic neurotransmission and chronic ethanol intake exert an inhibitory effect on cannabinoid receptor expression in cortical and striatal regions implicated in the reinforcing and addictive properties of ethanol.

  2. Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model

    E-Print Network [OSTI]

    Treusch, Sebastian

    2011-01-01T23:59:59.000Z

    Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

  3. Do changes in traditional coronary heart disease risk factors over time explain the association between socio-economic status and coronary heart disease?

    E-Print Network [OSTI]

    Franks, Peter; Winters, Paul C; Tancredi, Daniel J; Fiscella, Kevin A

    2011-01-01T23:59:59.000Z

    case-control study. Heart 2009, Franks P, Tancredi DJ,status in coronary heart disease risk estimation. Ann Famstatus and coronary heart disease risk prediction. JAMA

  4. Relationship of emphysema and airway disease assessed by CT to exercise capacity in COPD

    E-Print Network [OSTI]

    A. Diaz a,f, *, Brian Bartholmai b , Rau´l San Jose´ Este´par c , James Ross c , Shin Matsuoka d , Tsuneo Yamashiro d , Hiroto Hatabu d , John J. Reilly e , Edwin K. Silverman a,g , George R. Washko's Hospital, Boston MA, USA d Department of Radiology, Brigham and Women's Hospital, Boston MA, USA e Division

  5. Diseases of plantation forestry trees in eastern and southern Africa

    E-Print Network [OSTI]

    Diseases of plantation forestry trees in eastern and southern Africa J. Roux a*, G. Meke b , B are being allocated to the training of forestry staff andtreeimprovement.Theseefforts,aimedatstrengtheningthe forestry business, also embrace research on pests and diseases that might significantly reduce the value

  6. Motor signs during the course of Alzheimer disease

    E-Print Network [OSTI]

    to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits

  7. Harnessing plasticity to understand learning and treat disease

    E-Print Network [OSTI]

    Kilgard, Michael P.

    Harnessing plasticity to understand learning and treat disease Michael P. Kilgard The University, USA A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies sug- gest that cortical map plasticity is typically a transient phase that improves

  8. Lung Disease in Pediatrics: is it all in the Genes?

    E-Print Network [OSTI]

    Lung Disease in Pediatrics: is it all in the Genes? Jay K. Kolls, M.D.Jay K. Kolls, M.D. Chair with CF do worse than other? #12;· Outcomes are better at CF centers · There is huge variation in lung with the same mutation do worse than others? · Modifier genes ­ lung disease ­ Tgfb1 ­ Irfd1 ­ neutrophil

  9. AFBC co-firing of coal and hospital waste. Quarterly progress report, February 1, 1995--April 30, 1995

    SciTech Connect (OSTI)

    Stuart, J.M.

    1996-01-01T23:59:59.000Z

    The project objective is to design, construct, install, provide operator training and start-up a circulating fluidized bed combustion system at the Lebanon Pennsylvania Veteran`s Affairs Medical Center. This unit will co-fire coal and hospital waste providing inexpensive and efficient destruction of both general and infectious hospital waste and steam generation. The steam generated is as follows: (1) Steam = 20,000 lb/hr, (2) Temperature = 353 F (saturated), (3) Pressure = 125 psig, and (4) Steam quality ={approximately}98.5%. On February 3, 1995 DONLEE notified Lebanon VA and DOE-METC that additional funding would be required to complete the project. This funding, in the amount of $1,140,127, is needed to complete the facility, start-up and shakedown the facility, perform the test program and write the final report. On March 7, 1995 the vendors were notified that the Lebanon VA Steam Plant Project was shut down and that all work outside DONLEE was stopped pending obtaining additional funding.

  10. AFBC co-firing of coal and hospital waste. Quarterly progress report, May 1--July 31, 1995

    SciTech Connect (OSTI)

    Stuart, J.M.

    1995-12-31T23:59:59.000Z

    The project objective is to design, construct, install, provide operator training and start-up a circulating fluidized bed combustion system at the Lebanon, Pennsylvania Veteran`s Affairs Medical Center. This unit will co-fire coal and hospital waste providing lower cost steam for heating and possibly cooling (absorption chiller) and operation of a steam turbine-generator for limited power generation. This would permit full capacity operation of the FBC year round in spite of the VA laundry that was shut down as well as efficient destruction of both general and infectious hospital waste and steam generation. On February 3, 1995 Donlee notified Lebanon VA and DOE-METC that additional funding would be required to complete the project. This funding, in the amount of $1,140,127, is needed to complete the facility, start-up and shakedown the facility, perform the test program and write the final report. After review DOE-METC approved funding in the amount of $1,246,019 to be available August 1, 1995. This report describes each task of the project and its status.

  11. A Budget Impact Model for Paclitaxel-eluting Stent in Femoropopliteal Disease in France

    SciTech Connect (OSTI)

    De Cock, Erwin, E-mail: erwin.decock@unitedbiosource.com [United BioSource Corporation, Peri- and Post-Approval Services (Spain); Sapoval, Marc, E-mail: Marc.sapoval2@egp.aphp.fr [Hopital Europeen Georges Pompidou, Universite Rene Descartes, Department of Cardiovascular and Interventional Radiology (France)] [Hopital Europeen Georges Pompidou, Universite Rene Descartes, Department of Cardiovascular and Interventional Radiology (France); Julia, Pierre, E-mail: pierre.julia@egp.aphp.fr [Hopital Europeen Georges Pompidou, Universite Rene Descartes, Cardiovascular Surgery Department (France)] [Hopital Europeen Georges Pompidou, Universite Rene Descartes, Cardiovascular Surgery Department (France); Lissovoy, Greg de, E-mail: gdelisso@jhsph.edu [Johns Hopkins Bloomberg School of Public Health, Department of Health Policy and Management (United States); Lopes, Sandra, E-mail: Sandra.Lopes@CookMedical.com [Cook Medical, Health Economics and Reimbursement (Denmark)] [Cook Medical, Health Economics and Reimbursement (Denmark)

    2013-04-15T23:59:59.000Z

    The Zilver PTX drug-eluting stent (Cook Ireland Ltd., Limerick, Ireland) represents an advance in endovascular treatments for atherosclerotic superficial femoral artery (SFA) disease. Clinical data demonstrate improved clinical outcomes compared to bare-metal stents (BMS). This analysis assessed the likely impact on the French public health care budget of introducing reimbursement for the Zilver PTX stent. A model was developed in Microsoft Excel to estimate the impact of a progressive transition from BMS to Zilver PTX over a 5-year horizon. The number of patients undergoing SFA stenting was estimated on the basis of hospital episode data. The analysis from the payer perspective used French reimbursement tariffs. Target lesion revascularization (TLR) after primary stent placement was the primary outcome. TLR rates were based on 2-year data from the Zilver PTX single-arm study (6 and 9 %) and BMS rates reported in the literature (average 16 and 22 %) and extrapolated to 5 years. Net budget impact was expressed as the difference in total costs (primary stenting and reinterventions) for a scenario where BMS is progressively replaced by Zilver PTX compared to a scenario of BMS only. The model estimated a net cumulative 5-year budget reduction of Euro-Sign 6,807,202 for a projected population of 82,316 patients (21,361 receiving Zilver PTX). Base case results were confirmed in sensitivity analyses. Adoption of Zilver PTX could lead to important savings for the French public health care payer. Despite higher initial reimbursement for the Zilver PTX stent, fewer expected SFA reinterventions after the primary stenting procedure result in net savings.

  12. Enterprise Assessments Follow-up Review of the Hanford Site Chronic

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic Plan Departmentof EnergyPublic LawEnergyEnhanced5 U.S.Beryllium Disease

  13. Uncertainty and sensitivity analysis of chronic exposure results with the MACCS reactor accident consequence model

    SciTech Connect (OSTI)

    Helton, J.C. [Arizona State Univ., Tempe, AZ (United States); Johnson, J.D.; Rollstin, J.A. [Gram, Inc., Albuquerque, NM (United States); Shiver, A.W.; Sprung, J.L. [Sandia National Labs., Albuquerque, NM (United States)

    1995-01-01T23:59:59.000Z

    Uncertainty and sensitivity analysis techniques based on Latin hypercube sampling, partial correlation analysis and stepwise regression analysis are used in an investigation with the MACCS model of the chronic exposure pathways associated with a severe accident at a nuclear power station. The primary purpose of this study is to provide guidance on the variables to be considered in future review work to reduce the uncertainty in the important variables used in the calculation of reactor accident consequences. The effects of 75 imprecisely known input variables on the following reactor accident consequences are studied: crop growing season dose, crop long-term dose, water ingestion dose, milk growing season dose, long-term groundshine dose, long-term inhalation dose, total food pathways dose, total ingestion pathways dose, total long-term pathways dose, total latent cancer fatalities, area-dependent cost, crop disposal cost, milk disposal cost, population-dependent cost, total economic cost, condemnation area, condemnation population, crop disposal area and milk disposal area. When the predicted variables are considered collectively, the following input variables were found to be the dominant contributors to uncertainty: dry deposition velocity, transfer of cesium from animal feed to milk, transfer of cesium from animal feed to meat, ground concentration of Cs-134 at which the disposal of milk products will be initiated, transfer of Sr-90 from soil to legumes, maximum allowable ground concentration of Sr-90 for production of crops, fraction of cesium entering surface water that is consumed in drinking water, groundshine shielding factor, scale factor defining resuspension, dose reduction associated with decontamination, and ground concentration of 1-131 at which disposal of crops will be initiated due to accidents that occur during the growing season.

  14. Investigating organizational quality improvement systems, patient empowerment, organizational culture, professional involvement and the quality of care in European hospitals: the 'Deepening our Understanding of Quality Improvement in Europe (DUQuE)' project

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    Boncz I, Gulacsi L: Quality management and patient safety:on quality assessment and quality management in Europeandevelopment of hospital quality management systems in the

  15. Genetic Studies of Complex Human Diseases: Characterizing SNP-Disease Associations Using Bayesian Networks

    E-Print Network [OSTI]

    Han, Bing; Chen, Xue-wen; Talebizadeh, Zohreh; Xu, Hua

    2012-12-17T23:59:59.000Z

    (Suppl 3):S14 http://www.biomedcentral.com/1752-0509/6/S3/S14 © 2012 Han et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2...) heuristic search method can solve the classical XOR (Exclusive or) pro- blem [14]. We apply the EpiBN method to simulated datasets based on four disease models and three real datasets: Age-related Macular Degeneration (AMD) dataset, late-onset Alzheimer...

  16. Analysis of HLA-DP association with beryllium disease susceptibility in pooled exposed populations

    SciTech Connect (OSTI)

    Cesare Saltini, Massimo Amicosante

    2009-12-19T23:59:59.000Z

    Berylliosis or Chronic Beryllium Disease is a chronic granulomatous disorder primarily involving the lung associated with the exposition to low doses of Beryllium (Be) in the workplace. Berylliosis risk has been associated with the presence of a glutamate at position 69 of the HLA-DP beta chain (HLA-DPbetaGlu69) that is expressed in about 97% of disease cases and in 27% of the unaffected Be-exposed controls (p<0.0001) (Richeldi et al. Science 1993; 262: 242-244.12). Since this first observation of an immunogenetic association between berylliosis and HLA-DPbetaGlu69 a number of studies have confirmed the role of this marker as the primary gene of susceptibility of berylliosis (Richeldi et al Am J Ind Med. 1997; 32:337-40; Wang et al J. Immunol. 1999; 163: 1647-53; Saltini et al Eur Respir J. 2001 18:677-84; Rossman et al Am J Respir Crit Care Med. 2002 165:788-94). Moreover, a structure/function interaction between HLA-DP molecules carrying Glu69 and beryllium in driving and developing the immune response against beryllium itself has been observed as: (1) Be-specific T-cells clones obtained from berylliosis patients recognize beryllium as antigen only when presented in the context of the HLA-DP{beta}Glu69 molecules but not in the context of HLA-DP allelic variants carrying Lys69 (Lombardi G et al. J Immunol 2001; 166: 3549-3555), and (2) beryllium presents an affinity for the HLA-DP2, carrying the berylliosis marker of susceptibility HLA-DPGlu69, from 40 to 100 times higher that the HLA-DP molecule carrying Lys69 (Amicosante M. et al Hum. Immunol. 2001; 62: 686-93). However, although the immunogenetic studies performed have been addressed a number of different questions about the genetic association between berylliosis and/or beryllium sensitization, exposure levels to beryllium and HLA markers, a number of questions are still open in the field mainly due to the limitation imposed by the low number of subjects carrying berylliosis or beryllium sensitization enrolled in each immunogenetic study. In this context, the populations of the study already performed in this field by the University of Modena and Rome (by Prof. C. Saltini) and the University of Pennsylvania (by Prof. M. Rossman) have been evaluated by using similar HLA molecular typing methodologies and that both populations have now been followed up for a period of 4 to 7 years. The general objective of this study has to generate a larger data base comprising the two population with which analyze gene disease association with greater statistical power and ascertain the effect of lesser common gener variants which may be missed when analyzing associations on small populations. In particular addressing the role suggested in previous study such as: (1) the role of HLA-DP rare alleles and polymorphisms, and (2) the role of the HLA markers in disease progression from sensitization. The two populations from the already published studies (Saltini et al Eur Respir J. 2001 18:677-84; Rossman et al Am J Respir Crit Care Med. 2002 165:788-94) present similar aspects about: ethnicity, type and length of exposure to Be dust, a broadly similar association between beryllium related abnormalities and HLA. The two population have been pooled and evaluated using common criteria of diagnosis (Sensitized subject: at least 2 positive BeLPT tests each with 2 positive wells; CBD-affected subject: identification of well formed non-caseating granulomas on biopsy), follow up and HLA typing technique (complete HLA-DRB, DQB, DPB high resolution typing using amplification with sequence specific primers or sequence based typing). The two populations included 137 subjects with Beryllium hypersensitized (BH) and 155 Be-exposed controls. Inclusion criteria were met by one hundred and six subjects with Be-hypersensitivity of whom 55 were affected by CBD (age 52 {+-} 11 years; 50 caucasians, 2 African-Americans 2 Hispanics and 1 Asian; 46 males and 9 females; mean duration of Be-exposure 15 {+-} 9 years) and 51 showed Be-sensitization without lung granulomas detected by trans-bronchial biopsy (ag

  17. Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells

    SciTech Connect (OSTI)

    Stueckle, Todd A., E-mail: tstueckle@hsc.wvu.edu [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States); Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Lu, Yongju, E-mail: yongju6@hotmail.com [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States); Davis, Mary E., E-mail: mdavis@wvu.edu [Department of Physiology, West Virginia University, Morgantown, WV 26506 (United States); Wang, Liying, E-mail: lmw6@cdc.gov [Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States)] [Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 (United States); Jiang, Bing-Hua, E-mail: bhjiang@jefferson.edu [Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 (United States)] [Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Holaskova, Ida, E-mail: iholaskova@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Schafer, Rosana, E-mail: rschafer@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Barnett, John B., E-mail: jbarnett@hsc.wvu.edu [Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506 (United States); Rojanasakul, Yon, E-mail: yrojan@hsc.wvu.edu [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)] [Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506 (United States)

    2012-06-01T23:59:59.000Z

    Chronic arsenic exposure remains a human health risk; however a clear mode of action to understand gene signaling-driven arsenic carcinogenesis is currently lacking. This study chronically exposed human lung epithelial BEAS-2B cells to low-dose arsenic trioxide to elucidate cancer promoting gene signaling networks associated with arsenic-transformed (B-As) cells. Following a 6 month exposure, exposed cells were assessed for enhanced cell proliferation, colony formation, invasion ability and in vivo tumor formation compared to control cell lines. Collected mRNA was subjected to whole genome expression microarray profiling followed by in silico Ingenuity Pathway Analysis (IPA) to identify lung carcinogenesis modes of action. B-As cells displayed significant increases in proliferation, colony formation and invasion ability compared to BEAS-2B cells. B-As injections into nude mice resulted in development of primary and secondary metastatic tumors. Arsenic exposure resulted in widespread up-regulation of genes associated with mitochondrial metabolism and increased reactive oxygen species protection suggesting mitochondrial dysfunction. Carcinogenic initiation via reactive oxygen species and epigenetic mechanisms was further supported by altered DNA repair, histone, and ROS-sensitive signaling. NF-?B, MAPK and NCOR1 signaling disrupted PPAR?/?-mediated lipid homeostasis. A ‘pro-cancer’ gene signaling network identified increased survival, proliferation, inflammation, metabolism, anti-apoptosis and mobility signaling. IPA-ranked signaling networks identified altered p21, EF1?, Akt, MAPK, and NF-?B signaling networks promoting genetic disorder, altered cell cycle, cancer and changes in nucleic acid and energy metabolism. In conclusion, transformed B-As cells with their whole genome expression profile provide an in vitro arsenic model for future lung cancer signaling research and data for chronic arsenic exposure risk assessment. Highlights: ? Chronic As{sub 2}O{sub 3} exposure to lung epithelial cells resulted in a cancer-like phenotype. ? Mice injected with arsenic transformed (B-As) cells displayed metastatic tumors. ? Microarray profiling revealed changes in mitochondrial metabolism and ROS response. ? p21, EF1?, Akt, MAPK, PPAR? and NF-?B networks promoted pro-cancer signaling. ? B-As cells represent a lung cancer model to explore As-associated carcinogenesis.

  18. Quantum Leaps in Disease Detection Luis Garcia-Rubio, Ph.D.

    E-Print Network [OSTI]

    Meyers, Steven D.

    Quantum Leaps in Disease Detection Luis Garcia-Rubio, Ph.D. USF researchers are making quantum leaps in disease detection with the develop- ment of portable biosensors that can detect deadly diseases

  19. autoimmune disease triggered: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    disease (PD), to date there is still no definite cause or accepted treatment Hlava, Debbie Joy 2012-01-01 44 One (1) Postdoctoral position available at IMBB-FORTH, Heraklion,...

  20. artery disease results: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    have Chen, Yiling 49 Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study CiteSeer Summary:...