National Library of Energy BETA

Sample records for hospital chronic disease

  1. Interim Chronic Beryllium Disease

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-12-08

    Establishes Departmental expectations for addressing chronic beryllium disease throughout the Department until a Departmental rule on beryllium is promulgated. This Notice was replaced by final rule 10 CFR Part 850, Chronic Beryllium Disease Prevention Program, published December 8, 1999.

  2. Chronic obstructive pulmonary disease, pulmonary function and cardiovascular disease 

    E-Print Network [OSTI]

    McAllister, David Anthony

    2011-07-05

    Cardiovascular disease is common in Chronic Obstructive Pulmonary Disease (COPD), and forced expiratory volume in one second (FEV1) independently predicts cardiovascular morbidity and mortality. Pathological changes in ...

  3. ATTACHMENT 1: HANFORD SITE CHRONIC BERYLLIUM DISEASE PREVENTION...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    : HANFORD SITE CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM (CBDPP) COMMITTEE CHARTER The Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP) Committee is established...

  4. Transgenic Mouse Model of Chronic Beryllium Disease

    SciTech Connect (OSTI)

    Gordon, Terry

    2009-05-26

    Animal models provide powerful tools for dissecting dose-response relationships and pathogenic mechanisms and for testing new treatment paradigms. Mechanistic research on beryllium exposure-disease relationships is severely limited by a general inability to develop a sufficient chronic beryllium disease animal model. Discovery of the Human Leukocyte Antigen (HLA) - DPB1Glu69 genetic susceptibility component of chronic beryllium disease permitted the addition of this human beryllium antigen presentation molecule to an animal genome which may permit development of a better animal model for chronic beryllium disease. Using FVB/N inbred mice, Drs. Rubin and Zhu, successfully produced three strains of HLA-DPB1 Glu 69 transgenic mice. Each mouse strain contains a haplotype of the HLA-DPB1 Glu 69 gene that confers a different magnitude of odds ratio (OR) of risk for chronic beryllium disease: HLA-DPB1*0401 (OR = 0.2), HLA-DPB1*0201 (OR = 15), HLA-DPB1*1701 (OR = 240). In addition, Drs. Rubin and Zhu developed transgenic mice with the human CD4 gene to permit better transmission of signals between T cells and antigen presenting cells. This project has maintained the colonies of these transgenic mice and tested the functionality of the human transgenes.

  5. Chronic beryllium disease: Diagnosis and management

    SciTech Connect (OSTI)

    Rossman, M.D.

    1996-10-01

    Chronic beryllium disease is predominantly a pulmonary granulomatosis that was originally described in 1946. Symptoms usually include dyspnea and cough. Fever, anorexia, and weight loss are common. Skin lesions are the most common extrathoracic manifestation. Granulomatous hepatitis, hypercalcemia, and kidney stones can also occur. Radiographic and physiologic abnormalities are similar to those in sarcoidosis. While traditionally the pathologic changes included granulomas and cellular interstitial changes, the hallmark of the disease today is the well-formed granuloma. Immunologic studies have demonstrated a cell-mediated response to beryllium that is due to an accumulation of CD4{sup +} T cells at the site of disease activity. Diagnosis depends on the demonstration of pathologic changes (i.e., granuloma) and evidence that the granuloma was caused by a hypersensitivity to beryllium (i.e., positive lung proliferative response to beryllium). Using these criteria, the diagnosis of chronic beryllium disease can now be made before the onset of clinical symptoms. Whether, with early diagnosis, the natural course of this condition will be the same as when it was traditionally diagnosed is not known. Currently, corticosteroids are used to treat patients with significant symptoms or evidence of progressive disease. 21 refs.

  6. Chronic Beryllium Disease Prevention Program Report

    SciTech Connect (OSTI)

    Lee, S

    2012-03-29

    This document describes how Lawrence Livermore National Laboratory (LLNL) meets the requirements and management practices of federal regulation 10 CFR 850, 'Chronic Beryllium Disease Prevention Program (CBDPP).' This revision of the LLNL CBDPP incorporates clarification and editorial changes based on lessons learned from employee discussions, observations and reviews of Department of Energy (DOE) Complex and commercial industry beryllium (Be) safety programs. The information is used to strengthen beryllium safety practices at LLNL, particularly in the areas of: (1) Management of small parts and components; and (2) Communication of program status to employees. Future changes to LLNL beryllium activities and on-going operating experience will be incorporated into the program as described in Section S, 'Performance Feedback.'

  7. Chronic Beryllium Disease Prevention Environment, Safety, Health, and Quality Division

    E-Print Network [OSTI]

    Wechsler, Risa H.

    Chronic Beryllium Disease Prevention Program Environment, Safety, Health, and Quality Division SLAC-I-730-0A09M-001-R003 24 September 2013 #12;Publication Data This document was developed by the Beryllium program and published by ESHQ Publishing. Document Title: Chronic Beryllium Disease Prevention Program

  8. Tackling Africa's chronic disease burden: from the local to the global

    E-Print Network [OSTI]

    de-Graft Aikins, Ama; Unwin, Nigel; Agyemang, Charles; Allotey, Pascale; Campbell, Catherine; Arhinful, Daniel

    2010-04-19

    Abstract Africa faces a double burden of infectious and chronic diseases. While infectious diseases still account for at least 69% of deaths on the continent, age specific mortality rates from chronic diseases as a whole are actually higher in sub...

  9. Abstract--We present a formative study that examines what, when, and how participants in a chronic kidney disease (stage 5)

    E-Print Network [OSTI]

    in administration and evaluation of the results. We work with chronic kidney disease (CKD) stage 5 patients who must rigorously monitor their fluid and nutrient consumption. In general, patients must limit themselves to one. Lambert, M.S., R.D., C.D., is with the Nephrology Dietetics Department, Indiana University Hospital

  10. Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk

    E-Print Network [OSTI]

    Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus). Subsequently, the disease was diagnosed in black-tailed deer, Rocky Mountain elk (Williams & Young, 1982, 1992

  11. Development of Biomarkers for Chronic Beryllium Disease in Mice

    SciTech Connect (OSTI)

    Gordon, Terry

    2013-01-25

    Beryllium is a strategic metal, indispensable for national defense programs in aerospace, telecommunications, electronics, and weaponry. Exposure to beryllium is an extensively documented occupational hazard that causes irreversible, debilitating granulomatous lung disease in as much as 3 - 5% of exposed workers. Mechanistic research on beryllium exposure-disease relationships has been severely limited by a general lack of a sufficient CBD animal model. We have now developed and tested an animal model which can be used for dissecting dose-response relationships and pathogenic mechanisms and for testing new diagnostic and treatment paradigms. We have created 3 strains of transgenic mice in which the human antigen-presenting moiety, HLA-DP, was inserted into the mouse genome. Each mouse strain contains HLA-DPB1 alleles that confer different magnitude of risk for chronic beryllium disease (CBD): HLA-DPB1*0401 (odds ratio = 0.2), HLA-DPB1*0201 (odds ratio = 15), HLA-DPB1*1701 (odds ratio = 240). Our preliminary work has demonstrated that the *1701 allele, as predicted by human studies, results in the greatest degree of sensitization in a mouse ear swelling test. We have also completed dose-response experiments examining beryllium-induced lung granulomas and identified susceptible and resistant inbred strains of mice (without the human transgenes) as well as quantitative trait loci that may contain gene(s) that modify the immune response to beryllium. In this grant application, we propose to use the transgenic and Â?normal inbred strains of mice to identify biomarkers for the progression of beryllium sensitization and CBD. To achieve this goal, we propose to compare the sensitivity and accuracy of the lymphocyte proliferation test (blood and bronchoalveolar lavage fluid) with the ELISPOT test in the three HLA-DP transgenic mice strains throughout a 6 month treatment with beryllium particles. Because of the availability of high-throughput proteomics, we will also identify changes in potential protein biomarkers in beryllium-treated mice. We will correlate these findings with the ability of the transgenic mice to develop a beryllium-specific adaptive immune response in blood and bronchoalveolar lavage (BAL) fluid. We will also determine whether beryllium-responsive CD4+ T cells in blood and BAL correlate with the onset of granuloma formation. Thus, we will provide the scientific community with biomarkers of sensitization and disease progression for CBD. These biomarkers will serve as critical tools for development of improved industrial hygiene and therapeutic interventions.

  12. Developing effective chronic disease interventions in Africa: insights from Ghana and Cameroon

    E-Print Network [OSTI]

    de-Graft Aikins, Ama; Boynton, Petra; Atanga, Lem L.

    2010-04-19

    - vant to secondary prevention. Sedentary lifestyles have been strongly implicated in Ghana's chronic disease burden [45]. However there is also an emerging keep-fit culture in urban and rural fit and football clubs are also common across the country...

  13. Efficacy of DVD Technology in Chronic Obstructive Pulmonary Disease Self- Management Education of Rural Patients 

    E-Print Network [OSTI]

    Stellefson, Michael L.

    2010-01-14

    Despite the efficacy of pulmonary rehabilitation programs which assist patients in managing chronic obstructive pulmonary disease (COPD), the high costs and lack of availability of such programs pose considerable barriers ...

  14. Effect of chronic inhalation of inorganic arsenic on the risk of stillbirth in a community surrounding an agriculture chemical production facility: a hospital-based study 

    E-Print Network [OSTI]

    Ihrig, Melanie M

    1997-01-01

    EFFECT OF CHRONIC INHALATION OF INORGANIC ARSENIC ON THE RISK OF STILLBIRTH IN A COMMUNITY SURROUNDING AN AGRICULTURE CHEMICAL PRODUCTION FACILITY: A HOSPITAL-BASED STUDY A Thesis by MELANIE M. IHRIG Submitted to the Office of Graduate...

  15. Asthma is a chronic inflammatory disease of the lungs that is increasingly observed in developed countries

    E-Print Network [OSTI]

    Cai, Long

    Asthma is a chronic inflammatory disease of the lungs that is increasingly observed in developed in the lungs. However, characteristic to both forms of the disease is the airway- wall accumulation of T helper are expressed either by skin8 or lung epithelial cells and can influence the way in which epithelial cells

  16. Relation of aortic valve calcium to chronic kidney disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  17. Relation of Aortic Valve Calcium to Chronic Kidney Disease (from the Chronic Renal Insufficiency Cohort Study)

    E-Print Network [OSTI]

    2015-01-01

    with calcific aortic valve disease. Cardiovascular HealthA, et al. Cardiac valve calcification in haemodialysisCurtis JR. Aortic and mitral valve calcification in patients

  18. Comparing Online Community Structure of Patients of Chronic Diseases

    E-Print Network [OSTI]

    Maddali, Hanuma Teja; Margolis, Peter

    2015-01-01

    In this paper we compare the social network structure of people talking about Crohn's disease, Cystic Fibrosis, and Type 1 diabetes on Facebook and Twitter. We find that the Crohn's community's contributors are most emotional on Facebook and Twitter and most negative on Twitter, while the T1D community's communication network structure is most cohesive.

  19. Implementation Guide for use with 10 CFR Part 850, Chronic Beryllium Disease Prevention Program

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2001-01-04

    The Department of Energy (DOE) has established regulatory requirements for the Chronic Beryllium Disease Prevention Program (CBDPP) in Title 10 of the Code of Federal Regulations (CFR), Part 850 (10 CFR 850) [64 Federal Register (FR) 68854]. Supersedes DOE G 440.1-7. Certified 9-23-10.

  20. Low Prevalence of Chronic Beryllium Disease among Workers at a Nuclear Weapons Research and Development Facility

    SciTech Connect (OSTI)

    Arjomandi, M; Seward, J P; Gotway, M B; Nishimura, S; Fulton, G P; Thundiyil, J; King, T E; Harber, P; Balmes, J R

    2010-01-11

    To study the prevalence of beryllium sensitization (BeS) and chronic beryllium disease (CBD) in a cohort of workers from a nuclear weapons research and development facility. We evaluated 50 workers with BeS with medical and occupational histories, physical examination, chest imaging with HRCT (N=49), and pulmonary function testing. Forty of these workers also underwent bronchoscopy for bronchoalveolar lavage (BAL) and transbronchial biopsies. The mean duration of employment at the facility was 18 yrs and the mean latency (from first possible exposure) to time of evaluation was 32 yrs. Five of the workers had CBD at the time of evaluation (based on histology or HRCT); three others had evidence of probable CBD. These workers with BeS, characterized by a long duration of potential Be exposure and a long latency, had a low prevalence of CBD.

  1. Memorandum, Clarification of Title 10 of the Code of Federal Regulations, Part 850 (10 CPR 850), Chronic Beryllium Disease Prevention Program, Paragraph 850.34(g)

    Broader source: Energy.gov [DOE]

    The purpose of this memorandum is to clarification regarding the reporting of beryllium sensitization (BeS) and chronic beryllium disease (CBD) as required by paragraph 850.34(g) of the Chronic Beryllium Disease Prevention Program rule (10 CFR 850).

  2. Campath, calcineurin inhibitor reduction and chronic allograft nephropathy (3C) study: background, rationale, and study protocol

    E-Print Network [OSTI]

    Haynes, Richard; Baigent, Colin; Harden, Paul; Landray, Martin; Akyol, Murat; Asderakis, Argiris; Baxter, Alex; Bhandari, Sunil; Chowdhury, Paramit; Clancy, Marc; Emberson, Jonathan; Gibbs, Paul; Hammad, Abdul; Herrington, Will; Jayne, Kathy; Jones, Gareth; Krishnan, Nithya; Lay, Michael; Lewis, David; Macdougall, Iain; Nathan, Chidambaram; Neuberger, James; Newstead, Chas; Pararajasingam, Ravi; Puliatti, Carmelo; Rigg, Keith; Rowe, Peter; Sharif, Adnan; Sheerin, Neil; Sinha, Sanjay; Watson, Chris; Friend, Peter; 3C Study Collaborative Group

    2013-05-06

    Pereira, R Flynn, C Griffin Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust: N Sheerin, M Playford, B Boughen City Hospital, Nottingham University Hospitals NHS Trust: K Rigg, C Byrne, A Boswell Haynes et al. Transplantation Research... of Diet in Renal Disease Study Group. Ann Intern Med 1999, 130(6):461–470. 26. Mulay AV, Cockfield S, Stryker R, Fergusson D, Knoll GA: Conversion from calcineurin inhibitors to sirolimus for chronic renal allograft dysfunction: a systematic review...

  3. Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease

    E-Print Network [OSTI]

    Chang, Ruey-Kang R.; Chen, Alex Y.

    2010-01-01

    in infants with congenital heart disease. Pediatrics 114:children with congenital heart disease. The Cardiac StudySigni?cant Congenital Heart Disease Ruey-Kang R. Chang •

  4. Biomarkers of rapid chronic kidney disease progression in type 2 diabetes

    E-Print Network [OSTI]

    Looker, Helen C.; Colombo, Marco; Hess, Sibylle; Brosnan, Mary J.; Farran, Bassam; Dalton, R. Neil; Wong, Max C.; Turner, Charles; Palmer, Colin N. A.; Nogoceke, Everson; Groop, Leif; Salomaa, Veikko; Dunger, David B.; Agakov, Felix; McKeigue, Paul M.; Colhoun, Helen M.

    2015-07-22

    records ascertained prospectively. Covariate data including prescription information, blood pressure and anthropometry 16 results were obtained by extraction from the ongoing primary care and hospital diabetes electronic records. Laboratory data...

  5. Precision medicine in chronic disease management: The multiple sclerosis BioScreen

    E-Print Network [OSTI]

    2014-01-01

    Disease Management: The Multiple Sclerosis BioScreen Pierre-unpredictable disease like multiple sclerosis? Eur J NeurolHL. The challenge of multiple sclerosis: how do we cure a

  6. Percutaneous Transsplenic Access to the Portal Vein for Management of Vascular Complication in Patients with Chronic Liver Disease

    SciTech Connect (OSTI)

    Chu, Hee Ho; Kim, Hyo-Cheol Jae, Hwan Jun; Yi, Nam-Joon; Lee, Kwang-Woong; Suh, Kyung-Suk; Chung, Jin Wook; Park, Jae Hyung

    2012-12-15

    Purpose: To evaluate the safety and feasibility of percutaneous transsplenic access to the portal vein for management of vascular complication in patients with chronic liver diseases. Methods: Between Sept 2009 and April 2011, percutaneous transsplenic access to the portal vein was attempted in nine patients with chronic liver disease. Splenic vein puncture was performed under ultrasonographic guidance with a Chiba needle, followed by introduction of a 4 to 9F sheath. Four patients with hematemesis or hematochezia underwent variceal embolization. Another two patients underwent portosystemic shunt embolization in order to improve portal venous blood flow. Portal vein recanalization was attempted in three patients with a transplanted liver. The percutaneous transsplenic access site was closed using coils and glue. Results: Percutaneous transsplenic splenic vein catheterization was performed successfully in all patients. Gastric or jejunal varix embolization with glue and lipiodol mixture was performed successfully in four patients. In two patients with a massive portosystemic shunt, embolization of the shunting vessel with a vascular plug, microcoils, glue, and lipiodol mixture was achieved successfully. Portal vein recanalization was attempted in three patients with a transplanted liver; however, only one patient was treated successfully. Complete closure of the percutaneous transsplenic tract was achieved using coils and glue without bleeding complication in all patients. Conclusion: Percutaneous transsplenic access to the portal vein can be an alternative route for portography and further endovascular management in patients for whom conventional approaches are difficult or impossible.

  7. Asthma in Washington Asthma is a chronic lung disease that affects an estimated 16.4 million adults (aged 18 years)1

    E-Print Network [OSTI]

    Asthma in Washington Asthma is a chronic lung disease that affects an estimated 16.4 million adults to environmental triggers. The following data provide an overview of the burden of asthma in Washington (WA in Washington had asthma. Adult lifetime asthma prevalence was 14.9% and adult current asthma prevalence was 9

  8. Asthma in Wisconsin Asthma is a chronic lung disease that affects an estimated 16.4 million adults (aged 18 years)1

    E-Print Network [OSTI]

    of age, sex, race, or ethnicity. Although the exact cause of asthma is unknown and it cannot be curedAsthma in Wisconsin Asthma is a chronic lung disease that affects an estimated 16.4 million adults to environmental triggers. The following data provide an overview of the burden of asthma in Wisconsin (WI

  9. Asthma in Hawaii Asthma is a chronic lung disease that affects an estimated 16.4 million adults (aged 18 years)1

    E-Print Network [OSTI]

    of age, sex, race, or ethnicity. Although the exact cause of asthma is unknown and it cannot be curedAsthma in Hawaii Asthma is a chronic lung disease that affects an estimated 16.4 million adults to environmental triggers. The following data provide an overview of the burden of asthma in Hawaii (HI) compared

  10. Asthma in California Asthma is a chronic lung disease that affects an estimated 16.4 million adults (aged 18 years)1

    E-Print Network [OSTI]

    of age, sex, race, or ethnicity. Although the exact cause of asthma is unknown and it cannot be curedAsthma in California Asthma is a chronic lung disease that affects an estimated 16.4 million adults to environmental triggers. The following data provide an overview of the burden of asthma in California (CA

  11. Asthma in New York State Asthma is a chronic lung disease that affects an estimated 16.4 million adults (aged 18 years)1

    E-Print Network [OSTI]

    .S.), regardless of age, sex, race, or ethnicity. Although the exact cause of asthma is unknown and it cannotAsthma in New York State Asthma is a chronic lung disease that affects an estimated 16.4 million exposure to environmental triggers. The following data provide an overview of the burden of asthma in New

  12. Genetically Determined Height and Coronary Artery Disease

    E-Print Network [OSTI]

    Nelson, Christopher P.; Hamby, Stephen E.; Saleheen, Danish; Hopewell, Jenna C.; Zeng, Lingyao; Assimes, Themistocles L.; Kanoni, Stavroula; Willenborg, Christina; Burgess, Stephen; Amouyel, Philippe; Anand, Sonia; Blankenberg, Stefan; Boehm, Bernhard O.; Clarke, Robert J.; Collins, Rory; Dedoussis, George; Farrall, Martin; Franks, Paul W.; Groop, Leif; Hall, Alistair S.; Hamsten, Anders; Hengstenberg, Christian; Hovingh, G. Kees; Ingelsson, Erik; Kathiresan, Sekar; Kee, Frank; König, Inke R.; Kooner, Jaspal; Lehtimäki, Terho; März, Winifred; McPherson, Ruth; Metspalu, Andres; Nieminen, Markku S.; O'Donnell, Christopher J.; Palmer, Colin N.A.; Peters, Annette; Perola, Markus; Reilly, Muredach P.; Ripatti, Samuli; Roberts, Robert; Salomaa, Veikko; Shah, Svati H.; Schreiber, Stefan; Siegbahn, Agneta; Thorsteinsdottir, Unnur; Veronesi, Giovani; Wareham, Nicholas J.; Willer, Cristen J.; Zalloua, Pierre A.; Erdmann, Jeanette; Deloukas, Panos; Watkins, Hugh; Schunkert, Heribert; Danesh, John; Thompson, John R.; Samani, Nilesh J.

    2015-04-23

    of Tampere, Tampere (T.L.), and the Division of Cardiology, Department of Medicine, Helsinki University Central Hospital (M.S.N.), Department of Chronic Disease Prevention, National Institute for Health and Welfare (M.P., V.S.), and Hjelt Institute The New...

  13. he notion that chronic inflammation causes cancer is well documented, but exactly how the disease unfolds is not always clear. New work from HSPH digs into the devilish details that

    E-Print Network [OSTI]

    Reich, David

    T he notion that chronic inflammation causes cancer is well documented, but exactly how the disease unfolds is not always clear. New work from HSPH digs into the devilish details that link ulcerative

  14. The effects of maintenance schedules following pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomised controlled trial

    E-Print Network [OSTI]

    Wilson, Andrew M.; Browne, Paula; Olive, Sandra; Clark, Allan; Galey, Penny; Dix, Emma; Woodhouse, Helene; Robinson, Sue; Wilson, Edward C. F.; Staunton, Lindi

    2015-03-11

    %. Patients were excluded if they had significant cardiac or pulmonary disease other than COPD, a myocardial infarction within the previous 6 months or unstable angina, respiratory infection (defined as cough, anti- biotic use or purulent sputum within 4 weeks...

  15. Hospital Renovations

    Broader source: Energy.gov [DOE]

    Hospitals have a range of energy needs that vary from a typical building, and a number of renewable energy options may make more sense for a hospital, including process and biomass heating, photovoltaics (PV), and sustainability.

  16. Sex-specific differences in hyperoxic lung injury in mice: Implications for acute and chronic lung disease in humans

    SciTech Connect (OSTI)

    Lingappan, Krithika, E-mail: lingappa@bcm.edu [Department of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine, 1102 Bates Avenue, MC: FC530.01, Houston, TX 77030 (United States); Jiang, Weiwu; Wang, Lihua; Couroucli, Xanthi I. [Department of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine, 1102 Bates Avenue, MC: FC530.01, Houston, TX 77030 (United States); Barrios, Roberto [Department of Pathology and Genomic Medicine, The Methodist Hospital Physician Organization, 6565 Fannin Street, Suite M227, Houston, TX 77030 (United States); Moorthy, Bhagavatula [Department of Pediatrics, Section of Neonatology, Texas Children's Hospital, Baylor College of Medicine, 1102 Bates Avenue, MC: FC530.01, Houston, TX 77030 (United States)

    2013-10-15

    Sex-specific differences in pulmonary morbidity in humans are well documented. Hyperoxia contributes to lung injury in experimental animals and humans. The mechanisms responsible for sex differences in the susceptibility towards hyperoxic lung injury remain largely unknown. In this investigation, we tested the hypothesis that mice will display sex-specific differences in hyperoxic lung injury. Eight week-old male and female mice (C57BL/6J) were exposed to 72 h of hyperoxia (FiO{sub 2} > 0.95). After exposure to hyperoxia, lung injury, levels of 8-iso-prostaglandin F{sub 2} alpha (8-iso-PGF 2?) (LC–MS/MS), apoptosis (TUNEL) and inflammatory markers (suspension bead array) were determined. Cytochrome P450 (CYP)1A expression in the lung was assessed using immunohistochemistry and western blotting. After exposure to hyperoxia, males showed greater lung injury, neutrophil infiltration and apoptosis, compared to air-breathing controls than females. Pulmonary 8-iso-PGF 2? levels were higher in males than females after hyperoxia exposure. Sexually dimorphic increases in levels of IL-6 (F > M) and VEGF (M > F) in the lungs were also observed. CYP1A1 expression in the lung was higher in female mice compared to males under hyperoxic conditions. Overall, our results support the hypothesis that male mice are more susceptible than females to hyperoxic lung injury and that differences in inflammatory and oxidative stress markers contribute to these sex-specific dimorphic effects. In conclusion, this paper describes the establishment of an animal model that shows sex differences in hyperoxic lung injury in a temporal manner and thus has important implications for lung diseases mediated by hyperoxia in humans. - Highlights: • Male mice were more susceptible to hyperoxic lung injury than females. • Sex differences in inflammatory markers were observed. • CYP1A expression was higher in females after hyperoxia exposure.

  17. An investigation of the potentiating effects of ethanol on a chronic exposure of rats to 1,1,1-trichloroethane 

    E-Print Network [OSTI]

    Walker, DeWayne Harold

    1973-01-01

    accidents as an epidemic or a pandemic or a great accumulation of endemics, estimates that at any given time patients injured in accidents occupy 65, 000 American hospital beds. According to the National Health Survey, if injuries of a lesser severity... Alcoholism like accidents is considered by several authors to be a disease (4, 7 &12). The dictionary defines chronic alcoholism as a, "pathological condition& affect- ing chiefly the nervous and gastro-enteric systems, caused by the habitual use...

  18. 8th International Symposium on Growth and Nutrition in Children with Chronic Renal Disease: 28–30 May 2009, Oviedo, Asturias, Spain

    E-Print Network [OSTI]

    Santos, Fernando; Kaskel, Frederick J.; Mak, Robert H.; Caldas, Alberto

    2010-01-01

    28–30 May 2009, Oviedo, Asturias, Spain Fernando Santos &Hospital Universitario Central de Asturias, University ofOviedo, Oviedo, Asturias, Spain F. J. Kaskel Montefiore

  19. Cysticercosis in the United States: A Nationwide Hospitalization Study Assessing Burden of Disease, Fatality Risk Factors and Economic Impact of Infection

    E-Print Network [OSTI]

    O'Keefe, Kaitlin Ashley

    2013-01-01

    diagnoses and charge information stratified by in-hospitalcharge-related variables were calculated using hospital and discharge weights provided with the data, with statistical techniques designed for complex, stratified

  20. Reconfiguring Care for Chronic Disease with Home Monitoring: A Pilot Study Report on Telemetry-Supported Care for COPD Patients in the Lothian Region 

    E-Print Network [OSTI]

    Ure, Jenny; Kydd, Gillian; Tarling, Alex; McKinstry, Brian; Hanley, Janet; Pagliari, Claudia; Pinnock, Hilary; Sheikh, Aziz; MacNee, William; McCall Smith, Emily; Corscadden, Paddy

    2009-01-01

    A qualitative report of users' experiences of home telemonitoring in COPD (Chronic Obstructive Lung Disorder) in Lothian Region. This research, with patients, carers, nurses, physiotherapists and GPs provided an early ...

  1. Current trends in patients with chronic total occlusions undergoing coronary CT angiography

    E-Print Network [OSTI]

    2015-01-01

    improves success rates of PCI for chronic total occlusion.occlusion; NS, non-signi?cant; PCI, percutaneous coronarydisease or left main Early PCI One- vessel disease Two-

  2. Bone Mineral Density, Bone Turnover, and Systemic Inflammation in Non-cirrhotics with Chronic Hepatitis C

    E-Print Network [OSTI]

    Lai, JC; Shoback, DM; Zipperstein, J; Lizaola, B; Tseng, S; Terrault, NA

    2015-01-01

    non- cirrhotic chronic hepatitis B or C infection. World Jtransplantation for viral hepatitis in the United States.liver disease caused by hepatitis C and alcoholic liver

  3. The genetics of chronic obstructive pulmonary disease

    E-Print Network [OSTI]

    2001-01-11

    in developing countries such as India, Mexico, Cuba, Egypt, South Africa and China [4]. Severe ?1-antitrypsin deficiency is the only proven genetic risk factor for the development of COPD. Here we review the evidence from human studies that other genetic determi... of the non-smoker in the USA [4]. Exposure to dust in the coal and gold mining industries, and to gas in cadmium mining, has been linked to the development of airflow obstruction [16–18]. Expo- sure to dust and gases by underground tunnel workers has...

  4. Chronic Beryllium Disease Prevention Program What's New

    Broader source: Energy.gov [DOE]

    For additional information Contact: David Weitzman, Office of Worker Safety and Health Policy at (301) 903-5401 or: David.Weitzman@hq.doe.gov.

  5. The Chronic Kidney Disease-Colonic Axis

    E-Print Network [OSTI]

    Pahl, MV; Vaziri, ND

    2015-01-01

    dys- biosis with the use of probiotics have also been ratherCuevas ML: Effect of probiotics on human blood urea levels

  6. Beryllium disease

    SciTech Connect (OSTI)

    Not Available

    1991-12-20

    After two workers at the nuclear weapons plant at Oak Ridge National Laboratory in Tennessee were diagnosed earlier this year with chronic beryllium disease (CBD), a rare and sometimes fatal scarring of the lungs, the Department of Energy ordered up a 4-year probe. Now, part of that probe has begun - tests conducted by the Oak Ridge Associated Universities' Center for Epidemiological Research measuring beryllium sensitivity in 3,000 people who've been exposed to the metal's dust since Manhattan Project managers opened the Y-12 plant at Oak Ridge in 1943. Currently, 119 Y-12 employees process beryllium, which has a number of industrial uses, including rocket heat shields and nuclear weapon and electrical components. The disease often takes 20 to 25 years to develop, and the stricken employees haven't worked with beryllium for years. There is no cure for CBD, estimated to strike 2% of people exposed to the metal. Anti-inflammatory steroids alleviate such symptoms as a dry cough, weight loss, and fatigue. Like other lung-fibrosis diseases that are linked to lung cancer, some people suspect CBD might cause some lung cancer. While difficult to diagnose, about 900 cases of CBD have been reported since a Beryllium Case Registry was established in 1952. The Department of Energy (DOE) estimates that about 10,000 DOE employees and 800,000 people in private industry have worked with beryllium.

  7. Investigation of the phenotypic and genotypic determinants of disease susceptibility and progression in Crohn’s Disease 

    E-Print Network [OSTI]

    Phillips, Anne Mairead

    2011-07-05

    The inflammatory bowel diseases (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the gastrointestinal tract. Their aetiology is not fully understood but is thought ...

  8. Non-invasive markers of inflammation in cystic fibrosis lung disease 

    E-Print Network [OSTI]

    MacGregor, Gordon

    2010-01-01

    Cystic fibrosis (CF) lung disease is characterised by early airways infection and inflammation, chronic suppuration, frequent infective exacerbations and an increased influx of acute, and chronic inflammatory cells. The ...

  9. Understanding Hospital Admissions Close to the End of Life (ACE) Study

    E-Print Network [OSTI]

    Morris, Zoë S; Fyfe, Miranda; Momen, Natalie; Hoare, Sarah; Barclay, Stephen

    2013-03-11

    - istrative areas, with different demographic profiles rele- vant to place of death, including access to services. The first area is largely rural, with a university city and larger towns and areas of significant social deprivation and af- fluence. The second... Pulmonary Disease, or cancer who die within 72 hours of admission to of the two hospitals. Patients will be identified retrospectively with help from the hospitals’ Bereavement Services. These Ser- vices receive the hospital notes and organise the death cer...

  10. Effects of dietary polyunsaturated fatty acid supplementation on urinary eicosanoids in canine chronic renal failure 

    E-Print Network [OSTI]

    Crocker, Raquel Cristina

    1996-01-01

    Changes in renal eicosanoids may be an index of disease progression or response to therapy in chronic renal failure (CRF). This study measured urinary thromboxane B2 (TXB2) and prostaglandin E2 (PGE2) concentrations in ...

  11. Evaluation of Two Mobile Nutrition Tracking Applications for Chronically Ill Populations with Low Literacy Skills

    E-Print Network [OSTI]

    Connelly, Kay

    Evaluation of Two Mobile Nutrition Tracking Applications for Chronically Ill Populations with Low handheld application to assist CKD patients on Hemodialysis monitor and maintain their nutritional intake Hospital, Adult Renal Services Indianapolis, IN 46202 USA desireelambert@hotmail.com 4 Indiana University

  12. HOSPITAL VENTILATION STANDARDS AND ENERGY CONSERVATION: CHEMICAL CONTAMINATION OF HOSPITAL AIR. FINAL REPORT.

    E-Print Network [OSTI]

    Rainer, David

    2012-01-01

    CONSERVATION: CHH1ICAL CONTAMINATION OF HOSPITAL AIR na 1CONSERVATION CHEMICAL CONTAMINATION OF HOSPITAL AIR DavidCONSERVATION: CHEMICAL CONTAMINATION OF HOSPITAL AIR FINAL

  13. An immuno-epidemiological model for Johne's disease in cattle

    E-Print Network [OSTI]

    Martcheva, Maia

    An immuno-epidemiological model for Johne's disease in cattle Maia Martcheva1 Email: maia's disease in dairy cattle, this paper illustrates a novel way to link a within-host model for Mycobacterium reproduction model. Introduction Johne's disease (JD) in dairy cattle is a chronic infectious disease

  14. Good Samaritan Hospital`s energy efficiency improvements

    SciTech Connect (OSTI)

    Sterrett, R.; Dobberpuhl, W.; Gernet, B.; O`Brien, T.

    1995-06-01

    Arizona Public Service (APS) encourages its customers to use energy wisely by providing incentives to install energy efficient systems. APS provided an incentive to the Good Samaritan Hospital, located in Phoenix, Arizona, to install a Waste Heat Recovery Unit and an Economizer Cooling System to improve the performance of the hospital`s central plant. Waste heat recovered from the boilers stacks is used to preheat combustion air and boiler feed water. The Economizer Cooling System uses a plate and frame heat exchanger to cool the hospital with cold water produced by the cooling tower rather than an electrical chiller. To determine the effectiveness of these two systems APS initiated a project to monitor their performance. Alternative Energy Systems Consulting, Inc. (AESC) has installed instrumentation to monitor the performance of the above systems and will document their energy savings and effectiveness at reducing energy costs.

  15. HOSPITAL ENERGY AUDITS: A BIBLIOGRAPHY

    E-Print Network [OSTI]

    Pollack, R. I.

    2011-01-01

    49:43-6. "Hospital Builds Largest Solar Healthcare 1977ti ng build ings and building plans; buying solar; andBuild- ings and Community Systems, Assistant Secretary for Conservation and Solar

  16. Hospital valuation in emerging countries

    E-Print Network [OSTI]

    Segawa, Tsuyoshi, M.B.A. Massachusetts Institute of Technology

    2013-01-01

    Private health players in emerging countries have increased their presence and contributed to global health issues, but have been undervalued in financing. A variety of health players have evolved and hospitals have played ...

  17. Disease marketing and patient coping : a research study

    E-Print Network [OSTI]

    Lau, Hew Mun

    2012-01-01

    BACKGROUND: There is a high prevalence of disease marketing actions in the United States that are targeted towards patients with chronic illness. However, no study has assessed the direct effects of these marketing actions ...

  18. Dynamic Adaptive Remote Health Monitoring for Patients with Chronic Disease

    E-Print Network [OSTI]

    Suh, Myung-kyung

    2012-01-01

    such as Bluetooth, Zigbee, Wifi, etc. to monitor the health-such as Bluetooth, WiFi, Zigbee, etc. could support these

  19. Dynamic Adaptive Remote Health Monitoring for Patients with Chronic Disease

    E-Print Network [OSTI]

    Suh, Myung-kyung

    2012-01-01

    Jain. “Prediction models for a smart home based health carepressure data in the smart home-based health care system [

  20. Dynamic Adaptive Remote Health Monitoring for Patients with Chronic Disease

    E-Print Network [OSTI]

    Suh, Myung-kyung

    2012-01-01

    Table . . . . . . . . . . . . 3.12 SQL Query for Integratingfile system (Figure 3.10) into a SQL server, data should beinsert into the WANDA SQL server system. Data abstraction

  1. Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Maki, Steven 376-0088 372-9103 619-6170 438-2116 HAMTC Employee Health Advocate Domina, Kirk 376-3723 948-9763 VACANT HPMC OMS Holland, Nic 376-1085 (406) 544-4502 Cowley, Dana...

  2. Chronic Beryllium Disease Prevention Program (10 CFR 850) | Department of

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p a lCaribElectricSouthApplying2-2002 JulyBoth ofProject Notice

  3. Title 10 CFR Part 850, Chronic Beryllium Disease Prevention Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With U.S.Week DayDr.Theories81 to 1990 Timeline2 Hewlett-Packard

  4. Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP) Contact List

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (Journalvivo Low-Dose Lowï‚—34OctoberK West

  5. The architecture of safety: hospital design

    E-Print Network [OSTI]

    Joseph, Anjali; Rashid, Mahbub

    2007-12-01

    Purpose of review: This paper reviews recent research literature reporting the effects of hospital design on patient safety. Recent findings: Features of hospital design that are linked to patient safety in the literature include noise, air...

  6. Identification of novel genetic determinants in the high prevalence early-onset inflammatory bowel disease population in Scotland 

    E-Print Network [OSTI]

    Limbergen, Johan Emiel van

    2010-01-01

    Background & aims: The inflammatory bowel diseases (IBD), Crohn?s disease (CD) and ulcerative colitis (UC), are common causes of chronic gastrointestinal morbidity, affecting up to 1 in 250 of the general population in ...

  7. Urine Protein Analysis and Correlation of Urinary Biomarkers with Renal Disease Progression in Dogs with X-Linked Hereditary Nephropathy 

    E-Print Network [OSTI]

    Nabity, Mary B.

    2012-02-14

    Chronic kidney disease (CKD) is a major cause of illness in dogs, and it is commonly caused by glomerular diseases that result in proteinuria and a progressive decline in renal function. Despite the importance of glomerular ...

  8. SECTION 2 -HOSPITAL SALARY (salary paid to the employee by the hospital) SECTION 1 -PERSONAL DETAILS

    E-Print Network [OSTI]

    Tobar, Michael

    SECTION 2 - HOSPITAL SALARY (salary paid to the employee by the hospital) SECTION 1 - PERSONAL Location UWA School SECTION 4 - UWA SALARY (salary paid to the employee by the University) SECTION 3 - HOSPITAL SUPERANNUATION A base hospital salary amount (including a supplementary clinical loading) plus

  9. Infectious Causes of Chronic Illness

    E-Print Network [OSTI]

    Christner, Brent C.

    Features Infectious Causes of Chronic Illness Modeling the Earth Microbiome Cloudy with a Chance of Microbes ASM News MicrobeFebruary 2012 Y The News Magazine of the American Society for Microbiology Y Vol. 7 Y No. 2 #12;Cloudy with a Chance of Microbes Terrestrial microbes swept into clouds can catalyze

  10. Sorghum Diseases

    E-Print Network [OSTI]

    Amador, Jose; Berry, Robert W.; Frederiksen, Richard A.; Horne, C. Wendell; Thames, Walter H.; Toler, Robert W.

    1969-01-01

    Foreign animal disease can cause serious damage to the United States (US) agricultural sector and foot-and-mouth disease (FMD), in particular, poses a serious threat. FMD causes death and reduced fecundity in infected ...

  11. Original article Lentivirus-induced interstitial lung disease

    E-Print Network [OSTI]

    Boyer, Edmond

    Original article Lentivirus-induced interstitial lung disease: pulmonary pathology in sheep a chronic disease in sheep affecting, among other organs, the lungs. Interstitial pneumonitis is similar the pathological features of lungs of sheep naturally infected with visna-maedi virus with the results obtained

  12. Chronic Copper Poisoning in Sheep. 

    E-Print Network [OSTI]

    Boughton, I. B. (Ivan Bertrand); Hardy, W. T. (William Tyree)

    1934-01-01

    . Department of Agriculture. $In cooperation with Texas Extension Service. &In cooperation with State Department of Agriculture. The long-continued ingestion of salt mixtures containing rela- tively small percentages of copper sulphate caused chronic copper... poisoning among flocks of range sheep on several West Texas ranches during the past year. The salt licks were placed before the sheep as a means of preventing or controlling stomach worm infestation despite a! lack of experimental or field evidence...

  13. The Effects of Chronic Restraint Stress on Innate and Adaptive Immune Responses to Acute Theiler?s Murine Encephalomyelitis Virus Infection ? An Animal Model of Human Multiple Sclerosis 

    E-Print Network [OSTI]

    Steelman, Andrew Jonathan

    2009-05-15

    Multiple sclerosis (MS) is an immune-mediated prevalent chronic demyelinating and neurodegenerative disease of the central nervous system that begins with an abrupt onset during early adulthood. MS is idiopathic, but many factors are thought...

  14. Information Regarding MENINGOCOCCAL DISEASE

    E-Print Network [OSTI]

    . Meningococcal disease is a serious disease, caused by bacteria. Meningococcal disease is a contagious

  15. SECTION 2 -HOSPITAL SALARY (salary paid to the employee by the hospital) SECTION 1 -PERSONAL DETAILS

    E-Print Network [OSTI]

    Tobar, Michael

    SECTION 2 - HOSPITAL SALARY (salary paid to the employee by the hospital) SECTION 1 - PERSONAL with this document. Funding % Base Salary UWA % HOSPITAL % $ Private Practice Allowance $ Head of Department Allowance $ Superannuation $ SECTION 3 - UWA SALARY (salary paid to the employee by the University) Funding

  16. Elec 331 -Hospital Safety Power Distribution

    E-Print Network [OSTI]

    Pulfrey, David L.

    - Hospital Safety 7 Ground Fault Interrupter Test Reset Gnd Ref Hot Ref Hot Test / Reset Relay Relay : 5 to 30 mA, Test Plug Z Downstream GFI Protection #12;Elec 331 - Hospital Safety 8 = get-out-of-jail-free card · Test it before you touch it ­ Done to code? ­ Breaker labels accurate

  17. Role of altered intestinal microbiota in systemic inflammation and cardiovascular disease in chronic kidney disease

    E-Print Network [OSTI]

    2014-01-01

    et al. Tolerance of arabinoxylan-oligosaccharides and theirderived arabinoxylans, arabinoxylan-oligosaccharides, and

  18. Role of altered intestinal microbiota in systemic inflammation and cardiovascular disease in chronic kidney disease

    E-Print Network [OSTI]

    2014-01-01

    oligofructose-enriched inulin. Nephrol. Dial. Transplant.such as oligofructose inulin polymers, fructooligosac-

  19. Alzheimer caregiving stress and atherosclerotic disease : psychosocial and physiological pathways linking chronic stress to disease

    E-Print Network [OSTI]

    Buehler, Susan Kyung; Buehler, Susan Kyung

    2012-01-01

    Medicine, 52(3-4), 208-212. O'Leary, D. H. , Polak, J. F. ,A. , Sidney, S. , & O'Leary, D. H. (2010). Segment-specificand myocardial infarction (O'Leary et al. , 1999). Moreover,

  20. Role of altered intestinal microbiota in systemic inflammation and cardiovascular disease in chronic kidney disease

    E-Print Network [OSTI]

    2014-01-01

    91 Kruis W. Specific probiotics or ‘fecal transplantation’.Y, Nadal I, Sanchez E. Probiotics as drugs against humancharacteristics of effective probiotics. JAMA 3, 38–43 (

  1. Pulmonary arterial hypertension and cor pulmonale associated with chronic domestic woodsmoke inhalation

    SciTech Connect (OSTI)

    Sandoval, J.; Salas, J.; Martinez-Guerra, M.L.; Gomez, A.; Martinez, C.; Portales, A.; Palomar, A.; Villegas, M.; Barrios, R. )

    1993-01-01

    We describe the clinical, radiologic, functional, and pulmonary hemodynamic characteristics of a group of 30 nonsmoking patients with a lung disease that may be related to intense, long-standing indoor wood-smoke exposure. The endoscopic and some of the pathologic findings are also presented. Intense and prolonged wood-smoke inhalation may produce a chronic pulmonary disease that is similar in many aspects to other forms of inorganic dust-exposure interstitial lung disease. It affects mostly country women in their 60s, and severe dyspnea and cough are the outstanding complaints. The chest roentgenograms show a diffuse, bilateral, reticulonodular pattern, combined with normalized or hyperinflated lungs, as well as indirect signs of pulmonary arterial hypertension (PAH). On the pulmonary function test the patients show a mixed restrictive-obstructive pattern with severe hypoxemia and variable degrees of hypercapnia. Endoscopic findings are those of acute and chronic bronchitis and intense anthracotic staining of the airways appears to be quite characteristic. Fibrous and inflammatory focal thickening of the alveolar septa as well as diffuse parenchymal anthracotic deposits are the most prominent pathologic findings, although inflammatory changes of the bronchial epithelium are also present. The patients had severe PAH in which, as in other chronic lung diseases, chronic alveolar hypoxia may play the main pathogenetic role. However, PAH in wood-smoke inhalation-associated lung disease (WSIALD) appears to be more severe than in other forms of interstitial lung disease and tobacco-related COPD. The patients we studied are a selected group and they may represent one end of the spectrum of the WSIALD.

  2. Proteomic response to metabolic stress and cellular dysfunction in relation to Alzheimer's disease 

    E-Print Network [OSTI]

    Herrmann, Abigail Grace

    2014-06-28

    Vascular risk factors inducing a state of chronic cerebral hypoperfusion and metabolic stress are thought to influence the onset and progression of Alzheimer’s disease (AD). To investigate the complex molecular ...

  3. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's penumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  4. Respiratory disease in Utah coal miners

    SciTech Connect (OSTI)

    Rom, W.N.; Kanner, R.E.; Renzetti, A.D. Jr.; Shigeoka, J.W.; Barkman, H.W.; Nichols, M.; Turner, W.A.; Coleman, M.; Wright, W.E.

    1981-04-01

    Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's pneumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

  5. Rice Diseases

    E-Print Network [OSTI]

    Jones, Roger K.

    1987-01-01

    Alzheimer's disease (AD) is the most common form of the dementia in the aging population. ?-amyloid peptide (A?) has been indicated as the most important hallmark of AD and also is believed to be the central trigger of ...

  6. Building Green in Greensburg: Kiowa County Memorial Hospital...

    Energy Savers [EERE]

    Kiowa County Memorial Hospital Building Green in Greensburg: Kiowa County Memorial Hospital This poster highlights energy efficiency, renewable energy, and sustainable features of...

  7. Combined Heat and Power (CHP) Resource Guide for Hospital Applications...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Power (CHP) Resource Guide for Hospital Applications, 2007 Combined Heat and Power (CHP) Resource Guide for Hospital Applications, 2007 The objective of this 2007 guidebook is to...

  8. Fort Boise Veteran's Hospital District Heating Low Temperature...

    Open Energy Info (EERE)

    Fort Boise Veteran's Hospital District Heating Low Temperature Geothermal Facility Jump to: navigation, search Name Fort Boise Veteran's Hospital District Heating Low Temperature...

  9. Age-Dependent Sex Bias in Clinical Malarial Disease in Hypoendemic Regions

    E-Print Network [OSTI]

    Sharma, Shobhona

    of Fundamental Research, Mumbai, India, 2 Department of Clinical Pharmacology, Seth GS Medical College, KEM Hospital, Mumbai, India, 3 Kasturba Hospital for Infectious Diseases, Mumbai, India, 4 National Institute datasets (2000­2009) were captured for the hypoendemic Mumbai region in Western India. To validate findings

  10. Jackson Park Hospital Green Building Medical Center

    SciTech Connect (OSTI)

    William Dorsey; Nelson Vasquez

    2010-03-01

    Jackson Park Hospital completed the construction of a new Medical Office Building on its campus this spring. The new building construction has adopted the City of Chicago�s recent focus on protecting the environment, and conserving energy and resources, with the introduction of green building codes. Located in a poor, inner city neighborhood on the South side of Chicago, Jackson Park Hospital has chosen green building strategies to help make the area a better place to live and work.

  11. Occupational exposures and chronic respiratory symptoms. A population-based study

    SciTech Connect (OSTI)

    Korn, R.J.; Dockery, D.W.; Speizer, F.E.; Ware, J.H.; Ferris, B.G. Jr.

    1987-08-01

    Data from a random sample of 8515 white adults residing in 6 cities in the eastern and midwestern United States were used to examine the relationships between occupational exposures to dust or to gases and fumes and chronic respiratory symptoms; 31% of the population had a history of occupational dust exposure and 30% reported exposure to gas or fumes. After adjusting for smoking habits, age, gender, and city of residence, subjects with either occupational exposure had significantly elevated prevalences of chronic cough, chronic phlegm, persistent wheeze, and breathlessness. The adjusted relative odds of chronic respiratory symptoms for subjects exposed to dust ranged from 1.32 to 1.60. Subjects with gas or fume exposure had relative odds of symptoms between 1.27 and 1.43 when compared with unexposed subjects. Occupational dust exposure was associated with a higher prevalence of chronic obstructive pulmonary disease as defined by an FEV1/FVC ratio of less than 0.6, when comparing exposed and unexposed participants (OR = 1.53, 95% Cl = 1.17-2.08). Gas or fume exposure was associated with a small, but not significant, increase in COPD prevalence. Significant trends were noted for wheeze and phlegm with increasing duration of dust exposure. Although 36% of exposed subjects reported exposure to both dust and fumes, there was no evidence of a multiplicative interaction between the effects of the individual exposures. Smoking was a significant independent predictor of symptoms, but did not appear to modify the effect of dust or fumes on symptom reporting. These data, obtained in random samples of general populations, demonstrate that chronic respiratory symptoms and disease can be independently associated with occupational exposures.

  12. Occupational exposures and chronic respiratory symptoms: a population-based study

    SciTech Connect (OSTI)

    Korn, R.J.; Dockery, D.W.; Speizer, F.E.; Ware, J.H.; Ferris, B.G.

    1987-01-01

    Data from a random sample of 8515 white adults residing in six cities in the eastern and midwestern United States were used to examine the relationships between occupational exposures to dust or to gases and fumes and chronic respiratory symptoms. 31% of the population had a history of occupational dust exposure and 30% reported exposure to gas or to fumes. After adjusting for smoking habits, age, gender, and city of residence, subjects with either occupational exposure had significantly elevated prevalence of chronic cough, chronic phlegm, persistent wheeze, and breathlessness. The adjusted relative odds of chronic respiratory symptoms for subjects exposed to dust ranged from 1.32 to 1.60. Subjects with gas or fume exposure had relative odds of symptoms between 1.27 and 1.43 when compared to unexposed subjects. Occupational dust exposure was associated with a higher prevalence of chronic obstructive pulmonary disease (COPD) as defined by an FEV1/FVC ratio of less than 0.6, when comparing exposed and unexposed participants (OR=1.53, 95% CI=1.17-2.08). Gas or fume exposure was associated with a small, but not significant, increase in COPD prevalence. Significant trends were noted for wheeze and phlegm with increasing duration of dust exposure. Although 36% of exposed subjects reported exposure to both dust and fumes, there was no evidence of a multiplicative interaction between the effects of the individual exposures. Smoking was a significant independent predictor of symptoms, but did not appear to modify the effect of dust or fumes on symptom reporting. These data, obtained in random samples of general populations, demonstrate that chronic respiratory disease can be independently associated with occupational exposures.

  13. Challenges and Opportunities in Academic Hospital Medicine: Report from the Academic Hospital Medicine Summit

    E-Print Network [OSTI]

    Flanders, Scott A.; Centor, Bob; Weber, Valerie; McGinn, Thomas; DeSalvo, Karen; Auerbach, Andrew

    2009-01-01

    Association of Professors of Medicine Brad Sharpe, M.D. ,Staff, Society of Hospital Medicine Amy Woodward, Supportof General Internal Medicine. Disclosures: Dr. Auerbach is a

  14. "Lyme": Chronic Fatigue Syndrome By Another Name?

    E-Print Network [OSTI]

    Barbour, AG

    2015-01-01

    chronic fatigue syndrome (CFS) patients in their symptoms,with patients with the diagnosis of CFS. Patrick et al.on historical reference to CFS. Where I think the Patrick et

  15. Chronic respiratory effects of indoor formaldehyde exposure

    SciTech Connect (OSTI)

    Krzyzanowski, M.; Quackenboss, J.J.; Lebowitz, M.D.

    1990-01-01

    The relation of chronic respiratory symptoms and pulmonary function to formaldehyde (HCHO) in homes was studied in a sample of 298 children (6-15 years of age) and 613 adults. HCHO measurements were made with passive samplers two one-week periods. Data on chronic cough and phlegm, wheeze, attacks of breathlessness, and doctor diagnoses of chronic bronchitis and asthma were collected with self-completed questionnaires. Peak expiratory flow rates (PEFR) were obtained during the evenings and mornings for up to 14 consecutive days for each individual. Significantly greater prevalence rates of asthma and chronic bronchitis were found in children from houses with HCHO levels 60-120 ppb than in those less exposed, especially in children also exposed to environmental tobacco smoke. In children, levels of PEFR linearly decreased with HCHO exposure, with estimated decrease due to 60 ppb of HCHO equivalent to 22% of PEFR level in nonexposed children.

  16. BIOGEOCHEMISTRY LETTERS Chronic nitrogen additions suppress decomposition

    E-Print Network [OSTI]

    Templer, Pamela

    BIOGEOCHEMISTRY LETTERS Chronic nitrogen additions suppress decomposition and sequester soil carbon dioxide emis- sions, offsetting a substantial portion of greenhouse gas forcing of the climate system. Although a number of factors are responsible for this terrestrial carbon sink, atmospheric nitrogen

  17. FOOD SUSTAINABILITY REPORT QUEEN'S HOSPITALITY SERVICES

    E-Print Network [OSTI]

    Ellis, Randy

    FOOD SUSTAINABILITY REPORT QUEEN'S HOSPITALITY SERVICES May 2008 #12;In recent years, a sustainability movement has taken root at Queen's. The impacts of the movement can be seen across campus sustainability position within the their student government ­The AMS, The Engineer Society open the Tea Room

  18. BREAST CANCER SUPPORT RESOURCES Smilow Cancer Hospital

    E-Print Network [OSTI]

    O'Hern, Corey S.

    BREAST CANCER SUPPORT RESOURCES Smilow Cancer Hospital · Early Stage Breast Cancer Support Group · Advanced Stage Cancer Support Group · IMPACT ­ Young Cancer Survivors' Group Contact: Angela Khairallah, LCSW at 203-200-2360 Reach to Recovery ­ American Cancer Society 1-800-227-2345 www.cancer.org Sisters

  19. Assessing Patient Case Management Services with Adult Congenital Heart Disease Sensed Data

    E-Print Network [OSTI]

    Roussos, George

    1 Assessing Patient Case Management Services with Adult Congenital Heart Disease Sensed Data · Clinicians: Doctors & Nurses 7 How do Patients use Panaceia-iTV? Follow a treatment plan that includes-iTV Pilot Sites Brompton Hospital, London Adult Congenital Heart Center, Congenital Heart Disease Patients

  20. ORISE Resources: Hospital All-Hazards Self-Assessment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    partners with CDC to develop Hospital All-Hazards Self-Assessment to identify gaps in planning efforts The Hospital All-Hazards Self-Assessment, or HAH, is designed to help...

  1. Differentiating the hospital supply chain for enhanced performance

    E-Print Network [OSTI]

    DeScioli, Derek T

    2005-01-01

    This thesis determines how to design the supply chain policies in a hospital for the wide array of products that exist there. This research was done through interviewing staff and analyzing data of two hospitals implementing ...

  2. Coordinating Pediatric Medical Care during an Influenza Pandemic - Hospital Workbook

    SciTech Connect (OSTI)

    HCTT CHE

    2010-01-01

    This workbook is intended to assist hospitals with coordinating medical care for pediatric influenza-like illness across their community.

  3. Department of Hospitality & Tourism Management School of Business

    E-Print Network [OSTI]

    Kunkle, Tom

    academic year #12;DEPARTMENT OF HOSPITALITY & TOURISM MANAGEMENT Page 2 EXECUTIVE SUMMARY STRATEGIC HIGHLIGHTS: The Strategic Pathway to Excellence for the Hospitality & Tourism Management includes: Dr. Mc;DEPARTMENT OF HOSPITALITY & TOURISM MANAGEMENT Page 3 LOOKING AHEAD Five-Year HTMT Strategic Plan Objective

  4. Chronic respiratory effects of indoor formaldehyde exposure

    SciTech Connect (OSTI)

    Krzyzanowski, M.; Quackenboss, J.J.; Lebowitz, M.D. )

    1990-08-01

    The relation of chronic respiratory symptoms and pulmonary function to formaldehyde (HCHO) in homes was studied in a sample of 298 children (6-15 years of age) and 613 adults. HCHO measurements were made with passive samplers during two 1-week periods. Data on chronic cough and phlegm, wheeze, attacks of breathlessness, and doctor diagnoses of chronic bronchitis and asthma were collected with self-completed questionnaires. Peak expiratory flow rates (PEFR) were obtained during the evenings and mornings for up to 14 consecutive days for each individual. Significantly greater prevalence rates of asthma and chronic bronchitis were found in children from houses with HCHO levels 60-120 ppb than in those less exposed, especially in children also exposed to environmental tobacco smoke. In children, levels of PEFR decreased linearly with HCHO exposure, with the estimated decrease due to 60 ppb of HCHO equivalent to 22% of PEFR level in nonexposed children. The effects in asthmatic children exposed to HCHO below 50 ppb were greater than in healthy ones. The effects in adults were less evident: decrements in PEFR due to HCHO over 40 ppb were seen only in the morning, and mainly in smokers.

  5. ORIGINAL ARTICLE Acupuncture for Upper-Extremity Rehabilitation in Chronic

    E-Print Network [OSTI]

    Schaechter, Judith D.

    ORIGINAL ARTICLE Acupuncture for Upper-Extremity Rehabilitation in Chronic Stroke: A Randomized. Acupuncture for upper- extremity rehabilitation in chronic stroke: a randomized sham- controlled study. Arch acci- dent; Hemiparesis; Muscle spasticity; Range of motion, artic- ular; Rehabilitation. © 2005

  6. Edinburgh Research Explorer Lung Microbiota Changes Associated with Chronic

    E-Print Network [OSTI]

    Millar, Andrew J.

    Edinburgh Research Explorer Lung Microbiota Changes Associated with Chronic Pseudomonas aeruginosa Lung Infection and the Impact of Intravenous Colistimethate Sodium Citation for published version, 'Lung Microbiota Changes Associated with Chronic Pseudomonas aeruginosa Lung Infection and the Impact

  7. Gaucher Disease Inherited disorder

    E-Print Network [OSTI]

    Brutlag, Doug

    , spleen, and bone marrow ¡ Many types ¡ Possible link to Parkinson's Disease ¡ Affects 1 in 100,000 #12/> ¡ "Gaucher Disease." Genetics Home Reference ­ Your Guide to Understanding Genetic Conditions. US National Disease." Gene Review. Web 2 Oct. 2012. Genetics

  8. Digit frequency in the hospital! Designing for the task: What numbers are really used in hospitals?!

    E-Print Network [OSTI]

    Subramanian, Sriram

    .wiseman@cs.ucl.ac.uk The task and the problem! Medical workers program infusion pumps to administer drug treatments to patients. This involves entering the volume and rate of medication to be infused. ! ! Occasionally errors are made during into infusion pumps on the ward? Logs from pumps were collected from four different wards in one hospital

  9. Jackson Park Hospital Green Building Medical Center

    SciTech Connect (OSTI)

    William Dorsey; Nelson Vasquez

    2010-03-31

    Jackson Park Hospital completed the construction of a new Medical Office Building on its campus this spring. The new building construction has adopted the City of Chicago's recent focus on protecting the environment, and conserving energy and resources, with the introduction of green building codes. Located in a poor, inner city neighborhood on the South side of Chicago, Jackson Park Hospital has chosen green building strategies to help make the area a better place to live and work. The new green building houses the hospital's Family Medicine Residency Program and Specialty Medical Offices. The residency program has been vital in attracting new, young physicians to this medically underserved area. The new outpatient center will also help to allure needed medical providers to the community. The facility also has areas designated to women's health and community education. The Community Education Conference Room will provide learning opportunities to area residents. Emphasis will be placed on conserving resources and protecting our environment, as well as providing information on healthcare access and preventive medicine. The new Medical Office Building was constructed with numerous energy saving features. The exterior cladding of the building is an innovative, locally-manufactured precast concrete panel system with integral insulation that achieves an R-value in excess of building code requirements. The roof is a 'green roof' covered by native plantings, lessening the impact solar heat gain on the building, and reducing air conditioning requirements. The windows are low-E, tinted, and insulated to reduce cooling requirements in summer and heating requirements in winter. The main entrance has an air lock to prevent unconditioned air from entering the building and impacting interior air temperatures. Since much of the traffic in and out of the office building comes from the adjacent Jackson Park Hospital, a pedestrian bridge connects the two buildings, further decreasing the amount of unconditioned air that enters the office building. The HVAC system has an Energy Efficiency Rating 29% greater than required. No CFC based refrigerants were used in the HVAC system, thus reducing the emission of compounds that contribute to ozone depletion and global warming. In addition, interior light fixtures employ the latest energy-efficient lamp and ballast technology. Interior lighting throughout the building is operated by sensors that will automatically turn off lights inside a room when the room is unoccupied. The electrical traction elevators use less energy than typical elevators, and they are made of 95% recycled material. Further, locally manufactured products were used throughout, minimizing the amount of energy required to construct this building. The primary objective was to construct a 30,000 square foot medical office building on the Jackson Park Hospital campus that would comply with newly adopted City of Chicago green building codes focusing on protecting the environment and conserving energy and resources. The energy saving systems demonstrate a state of the-art whole-building approach to energy efficient design and construction. The energy efficiency and green aspects of the building contribute to the community by emphasizing the environmental and economic benefits of conserving resources. The building highlights the integration of Chicago's new green building codes into a poor, inner city neighborhood project and it is designed to attract medical providers and physicians to a medically underserved area.

  10. Hospital Energy Benchmarking Guidance - Version 1.0

    E-Print Network [OSTI]

    Singer, Brett C.

    2010-01-01

    tables that follow. Thermal Energy and Ventilation Providedsystems a. Identify thermal energy flows (cooling, spaceestimated from the thermal energy supplied to the hospital

  11. DOE Launches EnergySmart Hospitals to Promote Improved Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    healthy healing and work environments. Tools and resources will include advanced energy design guides for small and large hospitals, technology assessments, and an...

  12. DOE Launches EnergySmart Hospitals to Promote Improved Energy...

    Energy Savers [EERE]

    to not only save millions in potential energy costs, but also reduce carbon dioxide emissions. "Hospitals today find themselves at the nexus of two of our nation's most...

  13. Role of Sleep Disturbance in Chronic Hepatitis C Infection

    E-Print Network [OSTI]

    Carlson, Meghan D.; Hilsabeck, Robin C.; Barakat, Fatma; Perry, William

    2010-01-01

    et al. : Neurocognitive effects of the hepatitis C virus.Curr Hepatitis Rep 2009, 8:158–166.RD, Thomas HC: Chronic hepatitis C virus infection causes a

  14. BACHELOR OF SCIENCE IN HOSPITALITY MANAGMENET (Suggested 4 Year Plan)

    E-Print Network [OSTI]

    Benos, Panayiotis "Takis"

    Hospitality & Tourism Marketing 3 Credits per term 16 Credits per term 16 Credits per academic year 32 FOURTH YEAR, 1ST TERM CREDITS FOURTH YEAR, 2ND TERM CREDITS HMGT Level Elective 3 HMGT 1451 Senior SeminarBACHELOR OF SCIENCE IN HOSPITALITY MANAGMENET (Suggested 4 Year Plan) FIRST YEAR, 1ST TERM CREDITS

  15. The Hospital at Night (H@N) Wireless Communication System

    E-Print Network [OSTI]

    Oakley, Jeremy

    The Hospital at Night (H@N) Wireless Communication System: Evridiki (Evie) Fioratou1 [Evridiki A new wireless communication system implemented at Nottingham has been shown to enhance patient safety@N System Handover under the new H@N System The Hospital @ Night (H@N) Problem Out of hours patient care

  16. Forecasting Hospital Bed Availability Using Simulation and Neural Networks

    E-Print Network [OSTI]

    Kuhl, Michael E.

    Forecasting Hospital Bed Availability Using Simulation and Neural Networks Matthew J. Daniels, NY 14623 Elisabeth Hager Hager Consulting Pittsford, NY 14534 Abstract The availability of beds is a critical factor for decision-making in hospitals. Bed availability (or alternatively the bed occupancy

  17. Costs of chronic disease and an alternative to reduce these costs: case study of End Stage Renal Disease (ESRD) 

    E-Print Network [OSTI]

    Jang, Won-Ik

    2005-02-17

    ......................................................95 Separate Irrigation Dual Distribution Systems........................................100 Proposed Combined System .............................................................................100 Potential Benefits.......................96 Figure 11. Schematic of a dual municipal and irrigation water system ........................101 Figure 12. Schematic of proposed dual water supply system with reuse......................103 1 CHAPTER I INTRODUCTION...

  18. Impact of Palivizumab on RSV Hospitalizations for Children with Hemodynamically Significant Congenital Heart Disease

    E-Print Network [OSTI]

    Chang, Ruey-Kang R.; Chen, Alex Y.

    2010-01-01

    Furthermore, there might be off-label use of Synagis in HS-to assess the extent of off-label use before 2003. Despite

  19. Application of Machine Learning Techniques to Differential Diagnosis of Erythemato-Squamous Diseases

    E-Print Network [OSTI]

    Güvenir, H. Altay

    is an important problem in dermatology. The diseases in this group are psoriasis (C1), seboreic dermatitis (C2 diagnosis. For example the erythema and scaling of chronic dermatitis is less than of psoriasis, the koebner phenomenon is present only in psoriasis, lichen planus and pityriasis rosea. Itching and polygonal papules

  20. Comparison of Microbiological, Histological, and Immunomodulatory Parameters in Response to Treatment with Either Combination Therapy with Prednisone and Metronidazole or Probiotic VSL#3 Strains in Dogs with Idiopathic Inflammatory Bowel Disease 

    E-Print Network [OSTI]

    Rossi, Giacomo; Pengo, Graziano; Caldin, Marco; Piccionello, Angela Palumbo; Steiner, Jorg M.; Cohen, Noah D.; Jergens, Albert E.; Suchodolski, Jan S.

    2014-04-10

    Idiopathic inflammatory bowel disease (IBD) is a common chronic enteropathy in dogs. There are no published studies regarding the use of probiotics in the treatment of canine IBD. The objectives were to compare responses ...

  1. A case report of motor neuron disease in a patient showing significant level of DDTs, HCHs and organophosphate metabolites in hair as well as levels of hexane and toluene in blood

    SciTech Connect (OSTI)

    Kanavouras, Konstantinos; Tzatzarakis, Manolis N.; Mastorodemos, Vasileios; Plaitakis, Andreas; Tsatsakis, Aristidis M.

    2011-11-15

    Motor neuron disease is a devastating neurodegenerative condition, with the majority of sporadic, non-familial cases being of unknown etiology. Several epidemiological studies have suggested that occupational exposure to chemicals may be associated with disease pathogenesis. We report the case of a patient developing progressive motor neuron disease, who was chronically exposed to pesticides and organic solvents. The patient presented with leg spasticity and developed gradually clinical signs suggestive of amyotrophic lateral sclerosis, which was supported by the neurophysiologic and radiological findings. Our report is an evidence based case of combined exposure to organochlorine (DDTs), organophosphate pesticides (OPs) and organic solvents as confirmed by laboratory analysis in samples of blood and hair confirming systematic exposure. The concentration of non-specific dialkylphosphates metabolites (DAPs) of OPs in hair (dimethyphopshate (DMP) 1289.4 pg/mg and diethylphosphate (DEP) 709.4 pg/mg) and of DDTs (opDDE 484.0 pg/mg, ppDDE 526.6 pg/mg, opDDD 448.4 pg/mg, ppDDD + opDDT 259.9 pg/mg and ppDDT 573.7 pg/mg) were considerably significant. Toluene and n-hexane were also detected in blood on admission at hospital and quantified (1.23 and 0.87 {mu}g/l, respectively), while 3 months after hospitalization blood testing was found negative for toluene and n-hexane and hair analysis was provided decrease levels of HCHs, DDTs and DAPs. -- Highlights: Black-Right-Pointing-Pointer Exposure to pesticides and organic solvents might be a risk factor for sporadic MND. Black-Right-Pointing-Pointer We report a patient who developed progressive upper and lower motor neuron disease. Black-Right-Pointing-Pointer The patient had a history of occupational exposure to pesticides and solvents. Black-Right-Pointing-Pointer High DDTs' levels and increased levels of DMP and DEP were measured in his hair. Black-Right-Pointing-Pointer The patients' exposure to chemicals might have played a role in MND development.

  2. Understanding Heart Disease

    E-Print Network [OSTI]

    Shen, Jun

    1 Understanding Heart Disease Vietnamese Aspire For Healthy Hearts What Is Heart Disease? Heart the blood vessels going to the heart become narrow and clogged. Blood vessels are long, hollow tubes arteries. When arteries become clogged, it increases the risk of developing heart disease. When the heart

  3. Patterns of Care, Status Differentiation, and the Reproduction of Inequality in Hospital Nursing

    E-Print Network [OSTI]

    Kaiser, John William

    2015-01-01

    Perspectives on Gendered Inequality in Rules, Rights, andand the Reproduction of Inequality in Hospital Nursing byand the Reproduction of Inequality in Hospital Nursing by

  4. Incidence of Negative Appendectomy: Experience From a Company Hospital in Nigeria

    E-Print Network [OSTI]

    Osime, O C; Ajayi, P A

    2005-01-01

    From a Company Hospital in Nigeria OC Osime, FMCS, FICSHospital Benin City, Nigeria ABSTRACT Objective: The aim ofin a company hospital in Nigeria. Background: Appendicitis

  5. Chronic disease and early exposure to air-borne mixtures. 2. Exposure assessment

    SciTech Connect (OSTI)

    James Argo

    2007-10-15

    This work is part of a larger study of the impact of early exposure to releases from industry on the etiology of cancer. Releases from all kraft and sulfite mills, coke ovens, oil refineries, copper, nickel, and lead/zinc smelters operating in Canada during the exposure period of 1967-1970 have been determined. All plumes have been expressed in g BaP eq/d using the RASH methodology. The releases have been divided into process, boiler fuel, dioxin, and SO{sub 2} emissions. Combustion sources have been defined with FIREv6.23. Dioxin congenors are expected in all source types when the boiler fuel is heavy fuel oil, wood or wood bark, or coal. All about 90 communities examined have an inverted sex ratio. 53 refs., 2 figs., 4 tabs.

  6. @neurIST Chronic Disease Management through Integration of Heterogeneous Data

    E-Print Network [OSTI]

    Frangi, Alejandro

    the context of High Performance Computing. The @neurIST Project and the architecture of the system have been of Sheffield, Sheffield, UK k Information & Communications Technology Department, Universitat Pompeu Fabra by bringing together heterogeneous data, computing and complex processing services. The architecture

  7. The Gut as a Source of Inflammation in Chronic Kidney Disease

    E-Print Network [OSTI]

    Lau, WL; Kalantar-Zadeh, K; Vaziri, ND

    2015-01-01

    reported that oligofructose-inulin supplementation Nephronoligofructose-en- riched inulin. Nephrol Dial Transplant

  8. Asbestosis : an investigation into the chronic pulmonary disease of asbestos workers in this country 

    E-Print Network [OSTI]

    Grieve, Ian Martin Donaldson

    1927-01-01

    The Asbestos Industry, being comparatively young, plays but a modest part in the Nation's activities as a whole. That would appear to be the only excuse for the even more modest position which it holds in the literature ...

  9. Quality Adjustment for Health Care Spending on Chronic Disease: Evidence from Diabetes Treatment, 1999–2009

    E-Print Network [OSTI]

    Eggleston, Karen N

    Although US health care expenditures reached 17.6 percent of GDP in 2009, quality measurement in this important service sector remains limited. Studying quality changes associated with 11 years of health care for patients ...

  10. New Functional Imaging Technology to Differentiate between Chronic Obstructive Pulmonary Disease and Heart Failure

    E-Print Network [OSTI]

    Pollack, Charles V.; Slattery, David E

    2011-01-01

    improvement of congestive heart failure: a pilot study. BMCtesting and the accuracy of heart failure diagnosis in theemergency department. Circ Heart Fail. 2010 Jan;3(1):104-10.

  11. Development and preliminary evaluation of an innovative advanced chronic disease care model

    E-Print Network [OSTI]

    Bender, M; Hoefer, DR; Johnson, SK

    2013-01-01

    registered nurses (RNs), social workers, spiritual careThe Transitions program employs 2 RNs, each with a strongof the pro- gram director, RNs, and social worker. Indirect

  12. Treating Influenza(Flu) Do you have Asthma, Diabetes or Chronic Heart Disease?

    E-Print Network [OSTI]

    Huang, Haiying

    a high risk condition and you get flu symptoms. Symptoms can include fever, cough, sore throat, runny with the use of influenza antiviral drugs,including nausea,vomiting,dizziness, runny or stuffy nose,cough

  13. The Gut as a Source of Inflammation in Chronic Kidney Disease

    E-Print Network [OSTI]

    Lau, WL; Kalantar-Zadeh, K; Vaziri, ND

    2015-01-01

    Avenues: Prebiotics and Probiotics, and Anti-Inflammatorygut bacteria) and probiotics (living organisms ingested viaend points are needed [51] . Probiotics have also shown some

  14. Bone mineral density and fractures in older men with chronic obstructive pulmonary disease or asthma

    E-Print Network [OSTI]

    Dam, T.-T.; Harrison, S.; Fink, H. A.; Ramsdell, J.; Barrett-Connor, E.

    2010-01-01

    x ORIGINAL ARTICLE Bone mineral density and fractures inwas associated with lower bone mineral density (BMD) at theKeywords Bone loss . Bone mineral density . Elderly .

  15. Chronic Fatigue Syndrome As An Agent of Infectious Disease: A Review of Etiological Agents

    E-Print Network [OSTI]

    Hassenberg, Amy

    2011-01-01

    Syndrome. ” Science Patarca-Montero, Roberto. Medicalto this syndrome (Patarca-Montero 2004). It is not just a

  16. Update on the Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With WIPPfinalUnexpectedofWyko NT3300 OpticalUpdate on

  17. Update on the Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With WIPPfinalUnexpectedofWyko NT3300 OpticalUpdate onMay 9, 2013 Be

  18. Update on the Hanford Site Chronic Beryllium Disease Prevention Program (CBDPP)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking With WIPPfinalUnexpectedofWyko NT3300 OpticalUpdate onMay 9, 2013 Be

  19. Independent Oversight Inspection of the Hanford Site Chronic Beryllium Disease Prevention Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACT EVALUATION PLAN FOR THE SITE-218in a V2O5Ionic Liquid- January 2012

  20. Caregiver coordination as an enabler to a hospital to home initiative within the context of healthcare delivery

    E-Print Network [OSTI]

    Mousaid, Hassan

    2013-01-01

    The Hospital to Home architecture aims to provide a successful transition for patients leaving the hospital in order to improve health outcomes and minimize hospital readmission. This thesis analyzes the current hospital ...

  1. Model for a web-based hospital technology management system 

    E-Print Network [OSTI]

    Srinivasan, Niranjana

    2002-01-01

    The objective of this project is to design a hospital technology management system that is web-based. Technology management may be defined as 'an accountable, systematic approach to ensure that cost-effective, efficacious, safe and appropriate...

  2. Institutional expansion, community relations, and the hospital next door

    E-Print Network [OSTI]

    Solheim, Karla Nyreen

    2005-01-01

    Hospitals play many roles in a city: alternately, they may be caretakers of the sick, economic engines, intellectual hubs, major employers, and neighbors. This last role has evolved greatly over the last 45 years. The ...

  3. Improving product availability in hospitals : the role of inventory inaccuracies

    E-Print Network [OSTI]

    Opolon, David C. (David Cyrille)

    2010-01-01

    All players in the healthcare industry face increasing public and political pressure to improve quality of care and control costs. Hospitals, on the frontline of this challenge, face nursing shortages and financial ...

  4. Better than CFL? Dimmable LED Downlights in Hospitality Facilities Webinar

    Broader source: Energy.gov [DOE]

    LEDs represent less than 1% of the installed base of U.S. downlights, which in 2012 numbered about 700 million. In hospitality facilities, past efforts to reduce lighting energy use have mainly...

  5. Application of Thermal Storage, Peak Shaving and Cogeneration for Hospitals 

    E-Print Network [OSTI]

    McClure, J. D.; Estes, J. M.; Estes, M. C.

    1987-01-01

    case study to define and illustrate three energy planning strategies applicable to hospitals. These strategies are peak shaving, thermal storage, cogeneration and/or paralleling with the electric utility....

  6. Hospital Energy Benchmarking Guidance - Version 1.0

    E-Print Network [OSTI]

    Singer, Brett C.

    2010-01-01

    Fuel energy supplied to boilers. kBtu to hospital 1,2 •EUI: • Fuel energy to steam boilers. • Applicable when steamkBtu/sf-yr • Assumes pump & boiler fan energy small relative

  7. A survey of hospital inpatient education in Texas 

    E-Print Network [OSTI]

    Cochran, Susan Carol

    1978-01-01

    indicated that they have a need for inpatient education in their hospital. The most frequently cited programs for adult patient populations were: diabetes, preoperative, nutrition, respi ratory, and postnatal. For pediatric patient populations, the most... Rank Order of Specific Adult Patient Education Programs The Use of Externally-Produced and Self- Produced Teaching Aids Hospital Methods of Acquiring Information About the Impact of Inpatient Education When Patient Education Evaluation Occurs Chi...

  8. Third Report of the California Hospital Outcomes Project (1997): Report on Heart Attack, 1991-1993 Volume 1

    E-Print Network [OSTI]

    Romano, Patrick S; Luft, Harold S; Rainwater, Julie A

    1997-01-01

    Washington Medical Center West Valley Hospital and HealthWashington Medical Center West Valley Hospital and Health

  9. ORIGINAL ARTICLE Locomotor Rehabilitation of Individuals With Chronic Stroke

    E-Print Network [OSTI]

    ORIGINAL ARTICLE Locomotor Rehabilitation of Individuals With Chronic Stroke: Difference Between locomotor rehabilitation in individuals poststroke and how those who respond with clinically meaningful. Setting: Outpatient interdisciplinary rehabilitation research center. Participants: Hemiparetic subjects

  10. Active and passive coping strategies in chronic pain patients 

    E-Print Network [OSTI]

    Snow-Turek, Andrea Lynn

    1994-01-01

    This study assessed the validity of an active/passive conceptualization of coping in a sample of chronic pain patients (N = 84). The validity of active and passive coping dimensions was supported. The Coping Strategies ...

  11. Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia

    E-Print Network [OSTI]

    Landau, Dan A.

    Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by integrating whole-exome sequence and copy number to measure the ...

  12. Management of Low-Level Radioactive Waste from Research, Hospitals and Nuclear Medical Centers in Egypt - 13469

    SciTech Connect (OSTI)

    Hasan, M.A.; Selim, Y.T.; Lasheen, Y.F.

    2013-07-01

    The application of radioisotopes and radiation sources in medical diagnosis and therapy is an important issue. Physicians can use radioisotopes to diagnose and treat diseases. Methods of treatment, conditioning and management of low level radioactive wastes from the use of radiation sources and radioisotopes in hospitals and nuclear medicine application, are described. Solid Radioactive waste with low-level activity after accumulation, minimization, segregation and measurement, are burned or compressed in a compactor according to the international standards. Conditioned drums are transported to the interim storage site at the Egyptian Atomic Energy Authority (EAEA) represented in Hot Labs and Waste Management Center (HLWMC) for storage and monitoring. (authors)

  13. Wheat Diseases Atlas. 

    E-Print Network [OSTI]

    McCoy, Norman L.; Berry, Robert W.

    1982-01-01

    to wheat producers over the state on whose farms demonstrations have been conducted and pic tures for this publication were made. WhEAT DisEASES ATLAs Norman L. McCoy and Robert W Berry* INTRODUCTION Wheat diseases have caused untold human suffer ing...

  14. Adventures in Infectious Diseases

    ScienceCinema (OSTI)

    Fisher-Hoch, Susan [University of Texas School of Public Health

    2014-06-25

    Dr. Susan Fisher-Hoch, Virologist and Epidemiologist, will discuss her research and travels associated with viral hemorrhagic fevers. From the Ebola outbreak in Reston, Virginia to outbreaks of Crimean Congo Hemorrhagic Fever in South Africa, Senegal, and Saudi Arabia, Dr. Fisher-Hoch has studied and tracked the pathophysiology of these viral diseases. These studies have led her from the Center for Disease Control in the United States, to Lyon, France where she was instrumental in designing, constructing, and rendering operational a laboratory capable of containing some of the world's most dangerous diseases.

  15. Hospital Energy Benchmarking Guidance - Version 1.0

    SciTech Connect (OSTI)

    Singer, Brett C.

    2009-09-08

    This document describes an energy benchmarking framework for hospitals. The document is organized as follows. The introduction provides a brief primer on benchmarking and its application to hospitals. The next two sections discuss special considerations including the identification of normalizing factors. The presentation of metrics is preceded by a description of the overall framework and the rationale for the grouping of metrics. Following the presentation of metrics, a high-level protocol is provided. The next section presents draft benchmarks for some metrics; benchmarks are not available for many metrics owing to a lack of data. This document ends with a list of research needs for further development.

  16. Evaluation of Miscellaneous and Electronic Device Energy Use in Hospitals

    SciTech Connect (OSTI)

    Black, Douglas R.; Lanzisera, Steven M.; Lai, Judy; Brown, Richard E.; Singer, Brett C.

    2012-09-01

    Miscellaneous and electronic loads (MELs) consume about one-thirdof the primary energy used in US buildings, and their energy use is increasing faster than other end-uses. In healthcare facilities, 30percent of the annual electricity was used by MELs in 2008. This paper presents methods and challenges for estimating medical MELs energy consumption along with estimates of energy use in a hospital by combining device-level metered data with inventories and usage information. An important finding is that common, small devices consume large amounts of energy in aggregate and should not be ignored when trying to address hospital energy use.

  17. Osteocytes and Bone Diseases 

    E-Print Network [OSTI]

    Ren, Yinshi

    2015-05-06

    For many centuries, the osteoblast is considered to be responsible for bone formation. It is also believed that an imbalance of osteoblasts (weak) and osteoclasts (strong) is the main cause for bone diseases such as ...

  18. Health & Medicine Heart Disease

    E-Print Network [OSTI]

    Rogers, John A.

    See Also: Health & Medicine Heart Disease· Medical Imaging· Vioxx· Matter & Energy Electronics· Technology· Medical Technology· Reference Artificial heart· Biosensor· Circuit design· Machine· Science and stretchable electronics can map waves of electrical activity in the heart with better resolution and speed

  19. Soybean Diseases Atlas. 

    E-Print Network [OSTI]

    Anonymous,

    1979-01-01

    new disease which causes root and stem rot to soybeans and other legumes in several southern states. The earliest sympt om is yellowing of leaves of individual plants or patches of plants across fields. Leaves of damaged plants usually develop... new soybean disease restricts root development and causes an absence of nitrogen-fixing nodules. Plants are stunted in an irregular pattern that may resemble manganese toxicity, or moisture or potash deficiency. High nematode populations often...

  20. Nurse Absenteeism and Staffing Strategies for Hospital Inpatient Units

    E-Print Network [OSTI]

    Gupta, Diwakar

    for subpopulations such as cardiac and vascular, surgical, trauma, and pediatric patients. Nurses whose skillsNurse Absenteeism and Staffing Strategies for Hospital Inpatient Units Wen-Ya Wang1 , Diwakar Gupta Engineering Department, University of Minnesota Inpatient staffing costs are significantly affected by nurse

  1. Coming to a hospital near you: mass spectrometry imaging

    ScienceCinema (OSTI)

    Bowen, Ben

    2014-06-24

    Berkeley Lab's Ben Bowen discusses "Coming to a hospital near you: mass spectrometry imaging" in this Oct. 28, 2013 talk, which is part of a Science at the Theater event entitled Eight Big Ideas. Go here to watch the entire event with all 8 speakers.

  2. CALIFORNIA ENERGY COMMISSION SPECIAL DISTRICTS HOSPITALS & PUBLIC CARE COLLEGES & UNIVERSITIES

    E-Print Network [OSTI]

    Whether you are building a new facility, renovating an existing one, or want to reduce your energy billsCALIFORNIA ENERGY COMMISSION SPECIAL DISTRICTS HOSPITALS & PUBLIC CARE COLLEGES & UNIVERSITIES F O 2004 www.energy.ca.gov/efficiency/partnership Call (916) 654-4147 #12;The Energy Partnership Program

  3. Ubiquitous Computing at Point of Care in Hospitals

    E-Print Network [OSTI]

    Ubiquitous Computing at Point of Care in Hospitals: A User-Centered Approach Thesis for the degree, the dissemination of ubiquitous computing has been slow. Research on this type of technology has in many ways been, there is little design guidance that can help technology developers apply ubiquitous computing designs

  4. THE UNIVERSITY OF CONNECTICUT HEALTH CENTER JOHN DEMPSEY HOSPITAL

    E-Print Network [OSTI]

    Oliver, Douglas L.

    are designed with integrated regulator, contents gauge, flowmeter valve, and carrying handle. These special must be brought into the Hospital through the Receiving Dock or to a designated storage location for identification, proper labeling must also be present. Type of gas Color of Cylinder Air Yellow Carbon Dioxide

  5. Real option analysis of flexibility in a hospital emergency department expansion project : a systems approach

    E-Print Network [OSTI]

    Maseda, Luis J

    2008-01-01

    Hospital Emergency Departments across the United States have been experiencing demand in excess of their capacity to treat patients for the last two decades. This research considers a hypothetical case inspired by a hospital ...

  6. Investigation of PVC Pipe Failure at Terrell State Hospital – Final Report 

    E-Print Network [OSTI]

    Wei, G.; Deng, S.; Claridge, D. E.; Turner, W. D.

    2000-01-01

    At the request of Terrell State Hospital and MHMR, the Energy Systems Laboratory at Texas A&M University investigated the failure of the PVC pipes serving the chilled water loop at Terrell State Hospital. There were two ...

  7. Skin cancer in albinos at the University of Calabar Teaching Hospital, Calabar, Nigeria

    E-Print Network [OSTI]

    Asuquo, M E; Otei, O O; Omotoso, J; Bassey, E E

    2010-01-01

    Okoro AN. Albinism in Nigeria. A clinical and social study.Teaching Hospital, Calabar, Nigeria M E Asuquo 1 , O O OteiHospital, Calabar, Nigeria. mauefas@yahoo.com Abstract We

  8. Losing Jobs, Losing Income, and Worsening the Deficit? The Economic Impact of Connecticut's Hospital Tax

    E-Print Network [OSTI]

    Alpay, S. Pamir

    ? The Economic Impact of Connecticut's Hospital Tax & Reimbursement Policies? The Economic Impact of Connecticut's Hospital Tax & Reimbursement Policies Summary This brief analysis looks at the impact of the State of Connecticut progressively

  9. Third Report of the California Hospital Outcomes Project (1997): Report on Heart Attack, 1991-1993 Volume 3

    E-Print Network [OSTI]

    Romano, Patrick S; Luft, Harold S; Rainwater, Julie A

    1997-01-01

    Hills Medical Center‡ 190860 West Valley Hospital and HealthHills Medical Center‡ 190860 West Valley Hospital and HealthHills Medical Center‡ 190860 West Valley Hospital and Health

  10. Deep brain stimulation for chronic pain investigated with magnetoencephalography

    E-Print Network [OSTI]

    Cornelissen, Piers

    Deep brain stimulation for chronic pain investigated with magnetoencephalography Morten L CharitableTrust. Received11September 2006; accepted14 September 2006 Deep brain stimulation has shown by magne- toencephalography to map changes in neural activity induced by deep brain stimulation

  11. Blue Shield ensures uninterrupted access to quality medical care after Palm Drive Hospital ceases operations

    E-Print Network [OSTI]

    Ravikumar, B.

    Blue Shield ensures uninterrupted access to quality medical care after Palm Drive Hospital ceases and inpatient services due to the hospital's bankruptcy filing. This closure affects Blue Shield HMO plan members who have been utilizing Palm Drive Hospital services. Please be advised that Blue Shield

  12. DESCRIPTION OF HOSPITALS IN THE GREATER HARTFORD AREA Connecticut Children's Medical Center

    E-Print Network [OSTI]

    Page 27 DESCRIPTION OF HOSPITALS IN THE GREATER HARTFORD AREA Connecticut Children's Medical Center Connecticut Children's Medical Center (CCMC) is a nationally recognized, 187-bed not-for- profit children's hospital serving as the primary teaching hospital for the University of Connecticut School of Medicine

  13. `Pure air, pure water and good light' Sanitary reform in the Dublin hospitals, 1858-1898

    E-Print Network [OSTI]

    `Pure air, pure water and good light' Sanitary reform in the Dublin hospitals, 1858-1898 Irish Centre for Nursing & Midwifery History Spring-summer Seminar series Sanitary reform in the Dublin and hospital sanitation `Pure air, pure water and good light' Sanitary reform in the Dublin hospitals, 1858

  14. SPPS 403_Hospital / Health-System 1 rev. 5/26/15

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    SPPS 403_Hospital / Health-System 1 rev. 5/26/15 Hospital / Health-System Advanced Pharmacy Practice Experience SPPS 403 Office of Experiential Education James Colbert, Pharm.D. Farivar Jahansouz) 822-2216 #12;SPPS 403_Hospital / Health-System 2 rev. 5/26/15 I. Course Description: SPPS 403 (7 units

  15. SPPS 403_Hospital / Health-System 1 rev. 3/5/15

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    SPPS 403_Hospital / Health-System 1 rev. 3/5/15 Hospital / Health-System Advanced Pharmacy Practice Experience SPPS 403 Office of Experiential Education James Colbert, Pharm.D. Farivar Jahansouz, Pharm) 822-2216 #12;SPPS 403_Hospital / Health-System 2 rev. 3/5/15 I. Course Description: SPPS 403 (7 units

  16. Activated ClpP kills persisters and eradicates a chronic biofilm infection.

    SciTech Connect (OSTI)

    Conlon, Brian P.; Nakayasu, Ernesto S.; Fleck, Laura E.; LaFleur, Michael D.; Isabella, Vincent M.; Coleman, K.; Leonard, Steve N.; Smith, Richard D.; Adkins, Joshua N.; Lewis, Kim

    2013-11-21

    The current antibiotic crisis stems from two distinct phenomena-drug resistance, and drug tolerance. Resistance mechanisms such as drug efflux or modification prevent antibiotics from binding to their targets 1, allowing pathogens to grow. Antibiotic tolerance is the property of persister cells, phenotypic variants of regular bacteria 2. Antibiotics kill by corrupting targets, but these are inactive in dormant persisters, leading to tolerance. Persisters were first identified by Joseph Bigger in 1944, when he discovered a surviving sub-population of Staphylococcus following treatment with penicillin3. Persisters are largely responsible for recalcitrance of chronic diseases such as tuberculosis, and various infections associated with biofilms - endocarditis, osteomyelitis, infections of catheters and indwelling devices, and deep-seated infections of soft tissues 4. There are a number of redundant pathways involved in persister formation5,6 precluding development of drugs inhibiting their formation. The acyldepsipeptide antibiotic (ADEP 4) has been shown to activate the ClpP protease resulting in death of growing cells 7. Here we show that ADEP4 activated ClpP becomes a fairly non-specific protease and kills persister cells by degradation of over 400 intracellular targets. clpP mutants are resistant to ADEP4 7, but we find that they display increased susceptibility to killing by a range of conventional antibiotics. Combining ADEP4 with rifampicin leads to eradication of persisters, stationary and biofilm populations of Staphylococcus aureus in vitro and in a deep-seated murine infection. Target corruption/activation provides an approach to killing persisters and eradicating chronic infections.

  17. A Systematic Review of Side Effects of Nucleoside and Nucleotide Drugs Used for Treatment of Chronic Hepatitis B

    E-Print Network [OSTI]

    Khungar, Vandana; Han, Steven-Huy

    2010-01-01

    Nucleotides . Chronic hepatitis B virus infection .people have chronic hepatitis B virus infection (CHB). AmongDS: The natural history of hepatitis B virus infection. In

  18. HOSPITAL VENTILATION STANDARDS AND ENERGY CONSERVATION: A REVIEW OF GOVERNMENTAL AND PRIVATE AGENCY ENERGY CONSERVATION INITIATIVES

    SciTech Connect (OSTI)

    Banks, Robert S.; Rainer, David

    1980-03-01

    This report presents the results of a recent research project originally concerned with review of governmental initiatives for changes to hospital design and operation standards at both the federal and state levels. However. it quickly became apparent that concern with energy conservation was not impacting hospital environmental standards, especially at the state level, irrespective of the energy implications. Consequently, the study was redirected to consider all energy conservation initiatives directed toward design and operating practices unique to the hospital environment. The scope was limited to agency programs (i.e., not undertaken at the initiative of individual hospitals), applicable to non-federal public and private hospitals.

  19. Asbestos-related pulmonary disease in boilermakers

    SciTech Connect (OSTI)

    Demers, R.Y.; Neale, A.V.; Robins, T.; Herman, S.C. )

    1990-01-01

    Boilermakers are skilled building tradesmen who construct, repair, and dismantle boilers. The present study reports on the evaluation of members of a Michigan boilermaker's union for the presence of signs and symptoms of chronic pulmonary disease. Study variables included standardized evaluations of chest x-ray findings, pulmonary function testing, physical examination, and respiratory symptoms. An overall participation rate of 69% was achieved. A non-participant survey identified no significant differences between participants and non-participants in dyspnea, cough, age, or smoking history. Among participants with greater than 20 years experience in the trade, the mean FVC was 91% of predicted; the FEV1 was 86% of predicted; 25% showed at least a 1/0 profusion of interstitial markings on chest x-ray; 30% had bilateral pleural abnormalities; and 52% had audible inspiratory rales on physical examination. Forced vital capacity and forced expiratory volume at one second both decreased with years in the trade. Chest x-ray findings of interstitial fibrosis and pleural plaques were related to ten or more years in the trade, as were respiratory symptoms of pulmonary rales, wheeze, and dyspnea.

  20. Common Rose Diseases 

    E-Print Network [OSTI]

    Johnk, Janell

    2000-01-11

    is implied. 1. Plant roses in full sun.2. Use drip irrigation or soaker hoses. 3. Water in early morning.4. Selectively prune to open canopy and increase aircirculation. 5. Manage weeds and insects to prevent the spread of viruses. F i ve S te p..., making it moresusceptible to insect problems andother diseases.Management?Prune damaged orinfected canes . The black spot fungusover winters oncanes. Carefulpruning removesdamaged or infectedcanes and slowsdisease development. B lack Spot Rose varieties...

  1. Peanut Diseases Atlas. 

    E-Print Network [OSTI]

    Horne, Wendell C.

    1974-01-01

    Acknowledgments This publication was made possible by a grant from the Texas Peanut Producers Board to the Texas Agricultural Extension Service. This educational support in the area of peanut disease control is appreciated. The author also expresses... appreciation to producers who contributed through the voluntary check-off program and to those Extension staff members and research plant pathologists and nematologists who gave assistance and counsel during the prepara tion of this publication . Peanut...

  2. Inherited risk for common disease

    E-Print Network [OSTI]

    Banava, Helen

    2007-01-01

    Linkage disequilibrium studies have discovered few gene-disease associations for common diseases. The explanation has been offered that complex modes of inheritance govern risk for cancers, cardiovascular and cerebrovascular ...

  3. Vannida Ket Disease Case Presentation

    E-Print Network [OSTI]

    Brutlag, Doug

    -Sachs disease is classically diagnosed by an eye examination or behavior observation. Ganglion cells in the eye

  4. PLANT DISEASES IN SOUTH CAROLINA

    E-Print Network [OSTI]

    Stuart, Steven J.

    INDEX OF PLANT DISEASES IN SOUTH CAROLINA James H. Blake, Ed.D. Director, Home & Garden Information to compile a list of plant diseases occurring on cultivated and native plants in South Carolina. The data or conclusive list of the diseases of plants in South Carolina. New plants as well as new plant pathogens

  5. A Manual of Poultry Diseases

    E-Print Network [OSTI]

    Bell, R. R.; Flowers, A. I.; Grumbles, L. C.; Meinecke, C. F.; Patterson, C. M.; Wormell, B. C.; Hall, C. F.

    1965-01-01

    ............................................ Botlv Defense Against Disease 6 Manifestations of Disease ...................................................... 7 ........ Hatcherv and Breeder Flock Health Management 7 Hatchcrv Management and Sanitation ......... .... ........... 8 Principles... ......................................................... 10 Vaccination No Substitute for Sanitation .................... .. 11 Diseases for 'lIrhich Vaccines Are Available .................... 11 ....................... .................. Acl~ninistration of Vaccines ......... 11 -4 Suggested...

  6. Sulfur dioxide-induced chronic bronchitis in beagle dogs

    SciTech Connect (OSTI)

    Greene, S.A.; Wolff, R.K.; Hahn, F.F.; Henderson, R.F.; Mauderly, J.L.; Lundgren, D.L.

    1984-01-01

    This study was done to produce a model of chronic bronchitis. Twelve beagle dogs were exposed to 500 ppm sulfur dioxide (SO/sub 2/) for 2 h/d, 5d/wk for 21 wk and 4 dogs were sham-exposed to filtered ambient air for the same period. Exposure effects were evaluated by periodically examining the dogs using chest radiographs, pulmonary function, tracheal mucous clearance, and the cellular and soluble components of bronchopulmonary lavage fluids. Dogs were serially sacrificed after 13 and 21 wk of exposure and after 6 and 14 wk of recovery. Clinical signs produced in the SO/sub 2/-exposed dogs included mucoid nasal discharge, productive cough, moist rales on auscultation, tonsilitis, and conjunctivitis. Chest radiographs revealed mild peribronchiolar thickening. Histopathology, tracheal mucous clearance measurements, and lavage cytology were consistent with a diagnosis of chronic bronchitis. It is concluded that repeated exposure to 500 ppm SO/sub 2/ for 21 wk produced chronic bronchitis in the beagle dog. Complete recovery occurred within 5 wk following cessation of SO/sub 2/ exposure. 43 references, 2 figures, 2 tables.

  7. The Economy of Internet-Based Hospitality Exchange

    E-Print Network [OSTI]

    Tagiew, Rustam

    2015-01-01

    In this paper, we analyze and compare general development and individual behavior on two non-profit internet-based hospitality exchange services -- bewelcome.org and warmshowers.org. We measure the effort needed to achieve a real-life interaction, whereby the advantages of mutual altruism arise. The effort needed is the communication quantified in units of time. Since the amount of effort is not obvious to individual users, the development of the effort investing strategy is investigated. The impact of individual behavior on general development is discussed.

  8. Story County Hospital Wind Farm | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION JEnvironmental Jump to:EA EIS ReportEurope GmbHSoloPageBeforeCreek Wind Farm Jump to:StormHospital

  9. Large Hospital 50% Energy Savings: Technical Support Document

    SciTech Connect (OSTI)

    Bonnema, E.; Studer, D.; Parker, A.; Pless, S.; Torcellini, P.

    2010-09-01

    This Technical Support Document documents the technical analysis and design guidance for large hospitals to achieve whole-building energy savings of at least 50% over ANSI/ASHRAE/IESNA Standard 90.1-2004 and represents a step toward determining how to provide design guidance for aggressive energy savings targets. This report documents the modeling methods used to demonstrate that the design recommendations meet or exceed the 50% goal. EnergyPlus was used to model the predicted energy performance of the baseline and low-energy buildings to verify that 50% energy savings are achievable. Percent energy savings are based on a nominal minimally code-compliant building and whole-building, net site energy use intensity. The report defines architectural-program characteristics for typical large hospitals, thereby defining a prototype model; creates baseline energy models for each climate zone that are elaborations of the prototype models and are minimally compliant with Standard 90.1-2004; creates a list of energy design measures that can be applied to the prototype model to create low-energy models; uses industry feedback to strengthen inputs for baseline energy models and energy design measures; and simulates low-energy models for each climate zone to show that when the energy design measures are applied to the prototype model, 50% energy savings (or more) are achieved.

  10. Development of Graves' disease following radiation therapy in Hodgkin's disease

    SciTech Connect (OSTI)

    Loeffler, J.S.; Tarbell, N.J.; Garber, J.R.; Mauch, P.

    1988-01-01

    Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population.

  11. Demonstration of Advanced Technologies for Multi-Load Washers in Hospitality and Healthcare -- Wastewater Recycling Technology

    SciTech Connect (OSTI)

    Boyd, Brian K.; Parker, Graham B.; Petersen, Joseph M.; Sullivan, Greg; Goetzler, W.; Foley, K. J.; Sutherland, T. A.

    2014-08-14

    The objective of this demonstration project was to evaluate market-ready retrofit technologies for reducing the energy and water use of multi-load washers in healthcare and hospitality facilities. Specifically, this project evaluated laundry wastewater recycling technology in the hospitality sector and ozone laundry technology in both the healthcare and hospitality sectors. This report documents the demonstration of a wastewater recycling system installed in the Grand Hyatt Seattle.

  12. Uncovering opportunities for cost containment and operational improvements via shared practices between device manufacturer and hospital

    E-Print Network [OSTI]

    Machinani, Suman

    2015-01-01

    Background: Medical device manufacturers (suppliers) and hospitals (providers) face financial and operational stressors exacerbated by recent healthcare reform. Providers now face the prospect of decreased reimbursements ...

  13. Rebuilding it Better: Greensburg, Kansas, Kiowa County Memorial Hospital (Brochure) (Revised)

    Office of Energy Efficiency and Renewable Energy (EERE)

    This brochure details the sustainable and green aspects of the LEED Platinum-designed Kiowa County Memorial Hospital in Greensburg, Kansas.

  14. ORISE: WeB-MEDIS System Allows Hospitals to Gather and Track...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    WeB-MEDIS ORISE-developed system helps emergency responders and hospitals gather and track patient data during emergencies The Oak Ridge Institute for Science and Education...

  15. Gamma greenhouse: A chronic facility for crops improvement and agrobiotechnology

    SciTech Connect (OSTI)

    Azhar, M. Ahsanulkhaliqin, A. W.

    2014-02-12

    Gamma irradiation is one of the most common procedures in plant mutagenesis and agrobiotechnology activities. The procedures consist of chronic and acute gamma radiation. Generally, {sup 60}Co and {sup 137}Cs are gamma radiation sources for radiation processing with relatively high energy (half-life 5.27 years for {sup 60}Co and 30.1 years for {sup 137}Cs). The energy associated with gamma radiation is high enough to break the molecular bonds and ionize atoms without affecting structure of the atomic nucleus (avoiding induction of radioactivity). The Gamma Green House (GGH) is the only chronic irradiation facility in Malaysia, located at Malaysian Nuclear Agency (Nuclear Malaysia). GGH is used for induction of mutation in plants and other biological samples at low dose radiation over period of time depending on the nature and sensitivity of the plant species. The GGH consist of circular green house with 30 meters radius, control room and irradiator with interlock system. The irradiator produces low dose gamma radiation derived from Caesium-137 radioactive source. The biological samples can be exposed to low dose radiation in days, weeks, months or years. The current irradiation rate for GGH is 2.67 Gy/hr at 1 meter from the source. Chronic gamma irradiation produces a wider mutation spectrum and useful for minimizing radiation damages towards obtaining new improved traits for research and commercial values. The prospect of the gamma greenhouse is its uses in research, educations and services on induced mutation techniques for the improvement of plant varieties and microbes. In generating awareness and attract users to the facility, Nuclear Malaysia provides wide range of irradiation services for plant species and mutagenesis consultancies to academicians, students scientists, and plant breeders, from local universities, other research institutes, and growers. Charges for irradiation and consultancy services are at nominal rates. The utilization activities of the gamma greenhouse mainly cover Research and Development, Research Collaboration, Exchange of Information, Irradiation Services, Training Programs, Education, Exchange of Scientists and Seminars/ Conferences.

  16. The etiology of loin disease 

    E-Print Network [OSTI]

    Greeley, Ralph Gordon

    1966-01-01

    treatment has been discovered and the etiology of the disease has never been proven. In South Africa a similar disease, larnsiekte, has been recorded for centuries. In the 1920's intensive research in that country un- covered a chain of conditions... the similarity of lamsiekte and loin disease, and of the phosphorus deficiency that soils of South Africa and the Texas coastal plains have in common. In 1924 he began recommending the routine supplemental feeding of phos- phorus to range cattle (8). Where...

  17. Using Wikipedia to forecast diseases

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Molecular Biologist, of the Mathematical and Computational Epidemiology Team at Los Alamos National Laboratory Science Friday Interviews Mining Wikipedia Data to Track Disease...

  18. Reduced complexity of activity patterns in patients with Chronic Fatigue Syndrome: a case control study 

    E-Print Network [OSTI]

    Burton, C.; Knoop, H.; Popovic, N.; Sharpe, M.; Bleijenberg, G.

    ABSTRACT: BACKGROUND: Chronic fatigue syndrome (CFS) is an illness characterised by pervasive physical and mental fatigue without specific identified pathological changes. Many patients with CFS show reduced physical ...

  19. Bone Mineral Density, Bone Turnover, and Systemic Inflammation in Non-cirrhotics with Chronic Hepatitis C

    E-Print Network [OSTI]

    Lai, JC; Shoback, DM; Zipperstein, J; Lizaola, B; Tseng, S; Terrault, NA

    2015-01-01

    KP, Ludwig J. Chronic hepatitis. An update on terminologyet al. The prevalence of hepatitis C virus infection in thetransplantation for viral hepatitis in the United States.

  20. A case of aseptic pleuropericarditis in a patient with chronic plaque psoriasis under methotrexate therapy

    E-Print Network [OSTI]

    2010-01-01

    with chronic plaque psoriasis under methotrexate therapycutaneous and arthropatic psoriasis. Its safety profile issuffered from cutaneous psoriasis since the age of 30, when

  1. Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease

    E-Print Network [OSTI]

    Vaziri, ND; Liu, S; Farzaneh, SH; Nazertehrani, S; Khazaeli, M; Zhao, YY

    2015-01-01

    Peng A, Ye T, Rakheja D et al. The green tea polyphenol (-)-B. Protective effects of green tea polyphenols in the 6-OHDAM, Markovic P et al. Green tea (?)-epigallocatechin-gallate

  2. Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease

    E-Print Network [OSTI]

    2009-01-01

    Short-term effects of air pollution: a panel study of bloodindicates that ambient air pollution is associated withto daily changes in air pollution in Erfurt, Germany. 12

  3. Effect of matrix stiffness on the behaviour of liver resident cell populations in chronic liver disease and hepatocarcinogenesis 

    E-Print Network [OSTI]

    Gordon-Walker, Timothy Thomas; Walker, Timothy Thomas Gordon

    2014-07-05

    Introduction: The development of liver fibrosis is characterised by dramatic changes in the biomechanical composition and mechanical properties of the extracellular matrix (ECM). Increases in matrix stiffness associated ...

  4. Examining Public Health System Responses to the Chronic Diseases of HIV/AIDS and Diabetes: Experiences from Mexico and Brazil

    E-Print Network [OSTI]

    Gidi, Virginia Eve

    2010-01-01

    A. Cohn, Health reform in Brazil: lessons to consider. Am JPetersen, M.L. , et al. , Brazil, in The HIV Pandemic: localof the AIDS epidemic in Brazil: principal epidemiological

  5. Examining Public Health System Responses to the Chronic Diseases of HIV/AIDS and Diabetes: Experiences from Mexico and Brazil

    E-Print Network [OSTI]

    Gidi, Virginia Eve

    2010-01-01

    generations of reform in Mexico. Lancet, 2003. 362(9396): p.Carillo, and J.J. García, Mexico, in World Health Systems:Secretaria de Salud de Mexico and et al, Numeralia 2008:

  6. Dose-dependent deleterious and salutary actions of the Nrf2 inducer dh404 in chronic kidney disease

    E-Print Network [OSTI]

    Vaziri, ND; Liu, S; Farzaneh, SH; Nazertehrani, S; Khazaeli, M; Zhao, YY

    2015-01-01

    Arango M, Abderrahmane S et al. Resveratrol rescues mutantmechanisms of action of resveratrol, curcumin, sulforaphanes

  7. Office of Enterprise Assessments Follow-up Review of the Hanford Site Chronic Beryllium Disease Prevention Program - June 2015

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i nAandSummary Areas of the country that haveSummary by Program for FY

  8. Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease

    SciTech Connect (OSTI)

    Wu, Weibin; Institutes of Biomedical Science, Fudan University, Shanghai 200032 ; Zhu, Bo; Peng, Xiaomin; Zhou, Meiling; Jia, Dongwei; Gu, Jianxin; Institutes of Biomedical Science, Fudan University, Shanghai 200032

    2014-01-03

    Highlights: •FXR activity was impaired by chronic ethanol ingestion in a murine model of ALD. •Activation of FXR attenuated alcohol-induced liver injury and steatosis. •Activation of FXR attenuated cholestasis and oxidative stress in mouse liver. -- Abstract: Alcoholic liver disease (ALD) is a common cause of advanced liver disease, and considered as a major risk factor of morbidity and mortality worldwide. Hepatic cholestasis is a pathophysiological feature observed in all stages of ALD. The farnesoid X receptor (FXR) is a member of the nuclear hormone receptor superfamily, and plays an essential role in the regulation of bile acid, lipid and glucose homeostasis. However, the role of FXR in the pathogenesis and progression of ALD remains largely unknown. Mice were fed Lieber-DeCarli ethanol diet or an isocaloric control diet. We used a specific agonist of FXR WAY-362450 to study the effect of pharmacological activation of FXR in alcoholic liver disease. In this study, we demonstrated that FXR activity was impaired by chronic ethanol ingestion in a murine model of ALD. Activation of FXR by specific agonist WAY-362450 protected mice from the development of ALD. We also found that WAY-362450 treatment rescued FXR activity, suppressed ethanol-induced Cyp2e1 up-regulation and attenuated oxidative stress in liver. Our results highlight a key role of FXR in the modulation of ALD development, and propose specific FXR agonists for the treatment of ALD patients.

  9. Environmental Contributions to Allergic Disease

    E-Print Network [OSTI]

    Levetin, Estelle

    with increased exposure to air pollution and indoor contaminants such as house dust mites, cockroaches disease is more complex than increased exposure to pollution and allergens and that early childhood of outdoor factors to allergic disease. Influence of Exposure to Pollutants on the Manifestation of Allergic

  10. Publications Fish Disease Diagnosis and

    E-Print Network [OSTI]

    Publications Fish Disease Diagnosis and Basic Fishery Computer Programs The second edition of "Disease Diagnosis and Control in North American Marine Aquaculture," edited by Carl J. Sindermann edition should be a big help to aquaculturists and others involved in the detection, prevention

  11. Occupational Disease in Connecticut, 2014

    E-Print Network [OSTI]

    Oliver, Douglas L.

    Occupational Disease in Connecticut, 2014 This report covers data for 2012 and was prepared under contract for the State of Connecticut Workers' Compensation Commission, John A. Mastropietro, Chairman, as part of the Occupational Disease Surveillance Program, operated in cooperation with the Connecticut

  12. INDIAN INSTITUTE OF TECHNOLOGY KANPUR FORM FOR REIMBURSEMENT OF HOSPITALIZATION CHARGES

    E-Print Network [OSTI]

    Srivastava, Kumar Vaibhav

    . Place at which the patient availed hospitalization facility 8. Details of the amount claimed I. Medical Attendance (i) Charges for Pathological, Bacteriological, Radiological or other similar tests undertaken, Bacteriological, Radiological or other similar tests indicating: (a) The name of the hospital or laboratory

  13. AUTOMATED ANALYSIS OF VITAL SIGNS TO IDENTIFY PATIENTS WITH SUBSTANTIAL BLEEDING BEFORE HOSPITAL ARRIVAL

    E-Print Network [OSTI]

    AUTOMATED ANALYSIS OF VITAL SIGNS TO IDENTIFY PATIENTS WITH SUBSTANTIAL BLEEDING BEFORE HOSPITAL at a hospital. Previous analysis suggested that prehospital vital signs contained patterns indicating, a computational platform for real-time analysis of vital signs, for identification of substantial bleeding

  14. Technical Support Document: Development of the Advanced Energy Design Guide for Large Hospitals - 50% Energy Savings

    SciTech Connect (OSTI)

    Bonnema, E.; Leach, M.; Pless, S.

    2013-06-01

    This Technical Support Document describes the process and methodology for the development of the Advanced Energy Design Guide for Large Hospitals: Achieving 50% Energy Savings Toward a Net Zero Energy Building (AEDG-LH) ASHRAE et al. (2011b). The AEDG-LH is intended to provide recommendations for achieving 50% whole-building energy savings in large hospitals over levels achieved by following Standard 90.1-2004. The AEDG-LH was created for a 'standard' mid- to large-size hospital, typically at least 100,000 ft2, but the strategies apply to all sizes and classifications of new construction hospital buildings. Its primary focus is new construction, but recommendations may be applicable to facilities undergoing total renovation, and in part to many other hospital renovation, addition, remodeling, and modernization projects (including changes to one or more systems in existing buildings).

  15. Upper Temperature Tolerance of Loach Minnow under Acute, Chronic, and Fluctuating Thermal Regimes

    E-Print Network [OSTI]

    Bonar, Scott A.

    of loach minnow Rhinichthys cobitis: the lethal thermal method (LTM), chronic lethal method (CLMUpper Temperature Tolerance of Loach Minnow under Acute, Chronic, and Fluctuating Thermal Regimes, Tucson, Arizona 85748, USA Abstract.--We used four methods to estimate the upper lethal temperature

  16. Pride and Prejudice: Learning How Chronically Ill People Think about Food

    E-Print Network [OSTI]

    Pride and Prejudice: Learning How Chronically Ill People Think about Food Katie A. Siek, Kay H chronically ill population thinks about food, mentally organizes food, and interprets consumption-level icons interfaces that they could not accurately interpret. The results indicate that participants organized food

  17. Intoxication aigu et chronique au cadmium Acute and chronic cadmium poisoning

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Intoxication aiguë et chronique au cadmium Acute and chronic cadmium poisoning Pascal ANDUJAR1 poisoning Summary (176 words): Key words : cadmium - poisoning - pneumonia - nephropathy - osteomalacia or chemical pneumonitis. Cadmium chronic poisoning causes mainly renal tubulopathy and could be the cause

  18. High-density percutaneous chronic connector for neural prosthetics

    SciTech Connect (OSTI)

    Shah, Kedar G.; Bennett, William J.; Pannu, Satinderpall S.

    2015-09-22

    A high density percutaneous chronic connector, having first and second connector structures each having an array of magnets surrounding a mounting cavity. A first electrical feedthrough array is seated in the mounting cavity of the first connector structure and a second electrical feedthrough array is seated in the mounting cavity of the second connector structure, with a feedthrough interconnect matrix positioned between a top side of the first electrical feedthrough array and a bottom side of the second electrical feedthrough array to electrically connect the first electrical feedthrough array to the second electrical feedthrough array. The two arrays of magnets are arranged to attract in a first angular position which connects the first and second connector structures together and electrically connects the percutaneously connected device to the external electronics, and to repel in a second angular position to facilitate removal of the second connector structure from the first connector structure.

  19. A Novel Flexible Sinusoidal Probe for Chronic Extracellular Brain Recording

    E-Print Network [OSTI]

    Sohal, Harbaljit S; Jackson, Andrew; Baker, Stuart N; O'Neill, Anthony

    2015-01-01

    Current microelectrodes designed to record chronic neural activity suffer from recording instabilities due to the modulus mismatch between the electrode materials and the brain. We sought to address this by microfabricating a novel flexible neural probe. Our probe was fabricated from parylene-C with a WTi metal, using contact photolithography and reactive ion etching, with three design features to address this modulus mismatch: a sinusoidal shaft, a rounded tip and a polyimide anchoring ball. The anchor restricts movement of the electrode recording sites and the shaft accommodates the brain motion. We successfully patterned thick metal and parylene-C layers, with a reliable device release process leading to high functional yield and were able to sample stable neural activity for over 2 years with this probe. We have successfully optimized the fabrication process to produce a reliable probe with high functional yield. This novel reliably microfabricated probe can record stable neural activity for up to two yea...

  20. HOSPITAL VENTILATION STANDARDS AND ENERGY CONSERVATION: A SUMMARY OF THE LITERATURE WITH CONCLUSIONS AND RECOMMENDATIONS, FY 78 FINAL REPORT

    E-Print Network [OSTI]

    DeRoos, R.L.

    2011-01-01

    67: 49-57, CANZLER, B. Air conditioning in the hospital. 39(CECCATELLI, M. Air conditioning plant for operating suites.1973. CLARK, R. P. Air conditioning in hospital wards and

  1. The Edinburgh Royal Maternity Hospital and The Medicalisation of Childbirth in Edinburgh, 1844- I914: A Casebook-Centred Perspective 

    E-Print Network [OSTI]

    Nuttall, Alison M.

    This thesis examines the development of the Edinburgh Royal Maternity Hospital in the context of medical care in Edinburgh during the period 1844-1914. It is based primarily on casebooks of the hospital and, in particular, ...

  2. A medium-rise 1970’s maternity hospital in the east of England: resilience and adaptation to climate change

    E-Print Network [OSTI]

    Short, C. Alan; Giridharan, Renganathan; Lomas, Kevin J.

    2015-01-30

    study project for the ‘Design and Delivery of Robust Hospitals in a Changing Climate’ (DeDeRHECC) project, pursuing the methodology developed for that research. Environmental data was collected within representative spaces within the hospital, with some...

  3. Treating chronic arsenic toxicity with high selenium lentil diets

    SciTech Connect (OSTI)

    Sah, Shweta [Department of Ecosystem and Public Health, Faculty of Medicine, University of Calgary, Calgary, AB T2N 4Z6 (Canada); Vandenberg, Albert [Department of Plant Sciences, University of Saskatchewan, Saskatoon, SK S7N 5A8 (Canada); Smits, Judit, E-mail: judit.smits@ucalgary.ca [Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB T2N 4Z6 (Canada)

    2013-10-01

    Arsenic (As) toxicity causes serious health problems in humans, especially in the Indo-Gangetic plains and mountainous areas of China. Selenium (Se), an essential micronutrient is a potential mitigator of As toxicity due to its antioxidant and antagonistic properties. Selenium is seriously deficient in soils world-wide but is present at high, yet non-toxic levels in the great plains of North America. We evaluate the potential of dietary Se in counteracting chronic As toxicity in rats through serum biochemistry, blood glutathione levels, immunotoxicity (antibody response), liver peroxidative stress, thyroid response and As levels in tissues and excreta. To achieve this, we compare diets based on high-Se Saskatchewan (SK) lentils versus low-Se lentils from United States. Rats drank control (0 ppm As) or As (40 ppm As) water while consuming SK lentils (0.3 ppm Se) or northwestern USA lentils (< 0.01 ppm Se) diets for 14 weeks. Rats on high Se diets had higher glutathione levels regardless of As exposure, recovered antibody responses in As-exposed group, higher fecal and urinary As excretion and lower renal As residues. Selenium deficiency caused greater hepatic peroxidative damage in the As exposed animals. Thyroid hormones, triiodothyronine (T3) and thyroxine (T4), were not different. After 14 weeks of As exposure, health indicators in rats improved in response to the high Se lentil diets. Our results indicate that high Se lentils have a potential to mitigate As toxicity in laboratory mammals, which we hope will translate into benefits for As exposed humans. - Highlights: • We reduce chronic arsenic toxicity in rats with a whole food solution. • High selenium lentils decrease liver damage and increase blood glutathione levels. • High selenium lentil diets increase urinary and fecal arsenic excretion. • High selenium lentil diets decrease arsenic levels in kidney, the storage organ. • High selenium lentil diets reverse arsenic suppression of the B cell response.

  4. Early detection of contagious diseases

    DOE Patents [OSTI]

    Colston, Jr., Billy W. (San Ramon, CA); Milanovich, Fred P. (Lafayette, CA); Estacio, Pedro (Mission San Jose, CA); Chang, John (Walnut Creek, CA)

    2011-08-09

    This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

  5. Durability of Response in Children Treated with Pegylated Interferon alfa-2a +/- Ribavirin for Chronic Hepatitis C.

    E-Print Network [OSTI]

    2015-01-01

    +/- Ribavirin for Chronic Hepatitis C Kathleen B. Schwarz MDKamal NM. Burden of Pediatric Hepatitis C. World J Gastro 3.Adolescents with Chronic Hepatitis C. Gastro 2011;140:450-8.

  6. Inflammation as a potential mediator for the association between periodontal disease and Alzheimer’s disease

    E-Print Network [OSTI]

    Watts, Amber; Crimmins, Eileen M.; Gatz, Margaret

    2008-09-10

    Periodontal disease (PDD) is associated with increased risk of cardiovascular disease, cerebrovascular disease, and mortality in many studies, while other studies have begun to suggest an association of PDD with Alzheimer’s disease (AD). This paper...

  7. Alzheimer's Disease and Vitamin E

    E-Print Network [OSTI]

    Empey, Matthew

    1998-01-01

    Adelman A. Selegiline and vitamin E in Alzheimer's disease.bomb. Geriatrics Traber MG. Vitamin E in humans: Demand andJ, Cole GM, Schubert D. Vitamin E protects nerve cells from

  8. A Manual of Poultry Diseases

    E-Print Network [OSTI]

    Hall, C. F.; Bell, R. R.; Clifford, R. L., Jr.; Glass, S. E.; Grimes, J. E.; Grumbles, L. C.; Keahey, E. E.; Wormell, B. C.

    1971-01-01

    ........................................................ 7 Flock Health Management 7 Hatchery Management and Sanitation ............................ 8 Principles of Reasonable Drug Administration ................. .... 9 Drug Administration... Vaccines Are ................................................................... 10 Dangers of Vaccination ........................................................... 10 Vaccination-No Substitute for Sanitation ..... .................... 11 Diseases...

  9. Prudent behaviour accelerates disease transmission

    E-Print Network [OSTI]

    Scarpino, Samuel V; Hebert-Dufresne, Laurent

    2015-01-01

    Infectious diseases often spread faster near their peak than would be predicted given early data on transmission. Despite the commonality of this phenomena, there are no known general mechanisms able to cause an exponentially spreading dis- ease to begin spreading faster. Indeed most features of real world social networks, e.g. clustering1,2 and community structure3, and of human behaviour, e.g. social distancing4 and increased hygiene5, will slow disease spread. Here, we consider a model where individuals with essential societal roles-e.g. teachers, first responders, health-care workers, etc.- who fall ill are replaced with healthy individuals. We refer to this process as relational exchange. Relational exchange is also a behavioural process, but one whose effect on disease transmission is less obvious. By incorporating this behaviour into a dynamic network model, we demonstrate that replacing individuals can accelerate disease transmission. Furthermore, we find that the effects of this process are trivial w...

  10. Diarrheal Disease in Show Swine 

    E-Print Network [OSTI]

    Lawhorn, D. Bruce

    2007-02-27

    from the feces of recovered car- rier pigs or from contaminated premises, trailers or scales. Pigs affected with this disease usually become very sick. This organism infects the cells lining the cecum and spiral colon (the same area as whipworms... disease in show pigs. Infection occurs after pigs ingest microscopic whipworm eggs while rooting or eating in a contaminat- ed environment. Whipworm eggs remain viable for as long as 6 years so contaminated premises are an impor- tant source of infection...

  11. Controlling Diseases on Ornamental Plants. 

    E-Print Network [OSTI]

    Horne, C. Wendell; Johnson, Jerral D.; Walla, Walter J.

    1979-01-01

    on elms and other shade trees. Mushroom-type fu ngal growths appear on trunk, limbs or roots near the soil surface. Rots may be present for several years before mushrooms ap pear. Tree becomes sus ceptible to wi nd damage. Plants may die back..., irises, lilies, narcissus and tulips. ROOT DISEASES Disease Cotton root rot (fungi) Crown gall Mushroom root rot Symptoms Small flowering plants die within a few days. Shrubs and trees die more slowly. Large trees may die within several...

  12. Nitric oxide and carbon monoxide in cigarette smoke in the development of cardiorespiratory disease in smokers

    E-Print Network [OSTI]

    Borland, Colin David Ross

    1988-10-18

    in the Department of Respiratory Physiology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ. 2) The practical work was all performed by me excepting as follows. In Chapter 6 Karen Harmes ESc p~rformed the methaemoglobin analyses. In Chapter 5(2) Rachel... as to atmospheric po llution (Reid and Fletcher 1971) . Genetic susceptibility to obstructive lung disease, e.g. a 1 antitrypsin defic iency (Kueppers and Black 1974) is well recognised but it affects only a s mall proportion of s mokers. The relat ionshi p...

  13. Alcohol and HIV Disease Progression: Weighing the Evidence

    E-Print Network [OSTI]

    Hahn, Judith A.; Samet, Jeffrey H.

    2010-01-01

    Glass TR, et al. : Self-reported alcohol consumption and itsself-administering model of chronic alcohol consumption. J

  14. The Prevalence and Incremental Costs of Healthcare Associated Infections for Individuals Admitted for Potentially Preventable Hospitalization 

    E-Print Network [OSTI]

    Lorden, Andrea L

    2014-07-28

    Since there is a limited literature base concerning individuals admitted with a potentially preventable hospitalization (PPH) who acquired a healthcare associated infection (HAI), this research identified the prevalence and costs of individuals...

  15. Atendimento O cenrio o Setor de Radiologia do Hospital Universitrio da UFSC. Uma das salas

    E-Print Network [OSTI]

    Floeter, Sergio Ricardo

    Atendimento humanizado #12;O cenário é o Setor de Radiologia do Hospital Universitário da UFSC. Uma à mostra. O alvará sanitário do Serviço de Radiologia, revela o documento fixado na parede, teve

  16. THE IMPACT OF WORK UNIT AND ORGANIZATION SUPPORT ON HOSPITAL PATIENT SAFETY

    E-Print Network [OSTI]

    Kemper, Carol Ann

    2009-01-27

    Based on the construct of a culture of safety, the study purpose was to discern the relationships between Organization Support (OS) and Work Unit Support (WS) on Hospital Patient Safety. OS and WS were operationalized ...

  17. The effect on hospital air-conditioning system operation of soiled system elements

    SciTech Connect (OSTI)

    Olson, R.W.

    1986-01-01

    Air-Conditioning systems in a hospital are a crucial element in maintaining a safe and healthy environment. A clean, adequate supply of air is generally provided in the initial construction of the facility or during space remodeling. The presence of dirt or lint on the elements of the air-conditioning system reduces the available air volume and reduces the effectiveness of the heat exchanger surfaces. The ability of the air system to absorb moisture is also impaired and results in fogging and other moisture problems. This paper reviews (1) methods of identifying the condition and cleanliness of hospital air-conditioning systems; (2) methods of cleaning the elements of the hospital air-conditioning system; and (3) the effects on performance of dirt and lint in hospital air-conditioning systems.

  18. Nonprofit Hospitals’ Approach to Community Health Needs Assessment: A Mixed Methods Study 

    E-Print Network [OSTI]

    Pennel, Cara LeAnne

    2014-07-15

    are fulfilling this relatively new IRS requirement. The first paper presents findings based on the review, evaluation, and scoring of ninety-five CHNA/implementation strategies reports completed by Texas nonprofit hospitals. Reports were evaluated and scored...

  19. Researchers Use RFID to Fight SIDS This system would be especially useful in hospital

    E-Print Network [OSTI]

    Chiao, Jung-Chih

    NEWS Researchers Use RFID to Fight SIDS This system would be especially useful in hospital Vendors> Page 1 of 2RFID Journal - Researchers Use RFID to Fight SIDS - RFID (Radio Frequency Identifica

  20. Managing variability to improve quality, capacity and cost in the perioperative process at Massachusetts General Hospital

    E-Print Network [OSTI]

    Price, Devon J. (Devon Jameson)

    2011-01-01

    The widely held assumption is that to improve access and quality of health care, we need to spend more. In fact, that is not necessarily true. The results of this project, performed at Massachusetts General Hospital (MGH), ...

  1. CEE 812 Structural Engineering Seminar Series DMC Heart Hospital Pedestrian Bridge

    E-Print Network [OSTI]

    Kamat, Vineet R.

    CEE 812 ­ Structural Engineering Seminar Series DMC Heart Hospital Pedestrian Bridge by Carrie of the pedestrian bridge truss HSS connections for design and fabrication. It will further explore the challenges

  2. Energy Conservation Recommendations, Implementation Costs, and Projected Paybacks for Georgia's Targeted Schools and Hospitals Conservation Program 

    E-Print Network [OSTI]

    Brown, M. L.; Moore, D. M.

    1988-01-01

    During the past year the Georgia Tech Research Institute performed technical assistance studies on over 100 school and hospital buildings under a program funded by the Governor's Office of Energy Resources. This program is known as the Targeted...

  3. In sickness and in wealth : hospitals, community benefits, and the Affordable Care Act

    E-Print Network [OSTI]

    Mella, Katherine M. (Katherine Manuela)

    2014-01-01

    The new community benefit guidelines for non-profit hospitals enacted by the 2010 Patient Protection and Affordable Care Act (ACA) present major opportunities for the public health and planning fields alike. Given that ...

  4. A plan for Metropolitan State Hospital : imagery as a therapy for an institution

    E-Print Network [OSTI]

    McMurrin, Sterling James

    1988-01-01

    This thesis is both text and illustration to describe the process of transforming a state mental institution from an outdated, outmoded, conventional hospital into a living community. The goal of the project is to develop ...

  5. Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction

    SciTech Connect (OSTI)

    Deng Jun [State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072 (China); Graduate School of the Chinese Academy of Sciences, Beijing 100039 (China); Liu Chunsheng; Yu Liqin [State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072 (China); Zhou Bingsheng, E-mail: bszhou@ihb.ac.c [State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072 (China)

    2010-02-15

    Tribromophenol (2,4,6-TBP) is ubiquitously found in aquatic environments and biota. In this study, we exposed zebrafish embryos (F{sub 0}; 2'''' days post-fertilization, dpf) to environmental concentration (0.3 mug/L) and a higher concentration (3.0 mug/L) of TBP and assessed the impact of chronic exposure (120 dpf) on reproduction. TBP exposure did not cause a significant increase in the malformation and reduction in the survival in the F{sub 0}-generation fish. After TBP exposure, the plasma testosterone and estradiol levels significantly increased in males and decreased in females. The transcription of steroidogenic genes (3beta-HSD, 17beta-HSD, CYP17, CYP19A, CYP19B) was significantly upregulated in the brain and testes in males and downregulated in the brain and ovary in females. TBP exposure significantly downregulated and upregulated the expression of VTG in the liver of female and male fish, respectively. Meanwhile, TBP exposure altered the sex ratio toward a male-dominant state. The F{sub 1}-generation larvae exhibited increased malformation, reduced survival, and retarded growth, suggesting that TBP in the aquatic environment has significant adverse effects on fish population.

  6. the heart truth What is heart Disease?

    E-Print Network [OSTI]

    Shen, Jun

    the heart truth® for Women What is heart Disease? Coronary heart disease (CHD) is the most common form of heart disease. Usually referred to simply as "heart disease," it is a disorder of the blood vessels of the heart in which a waxy substance called plaque builds up in the coronary (heart) arteries

  7. 200 Plant Disease / Vol. 87 No. 2200 Disease Notes

    E-Print Network [OSTI]

    Pappu, Hanu R.

    Leaf Curl Begomoviruses from Pakistan. S. L. Shih, W. S. Tsai, and S. K. Green, The Asian Vegetable Disease Research Institute, National Agricultural Research Centre, Islamabad, Pakistan; M. A. Rezaian in Pakistan. One chili sample with leaf curl symptoms was collected in 1998 in Multan (Punjab Province

  8. ANALYZING MUSCULAR PAIN AND THE EFFECTS OF EXERCISE ON CHRONIC PAIN

    E-Print Network [OSTI]

    Sharma, Neena

    2008-08-22

    device and Fos expression of the dorsal horn spinal cells. The effect of aerobic exercise on chronic pain state was tested with behavioral and molecular measures. The results indicated that acid injections induced cutaneous and muscle hyperalgesia...

  9. Viral delivery of recombinant growth hormone to rescue effects of chronic stress on hippocampal learning

    E-Print Network [OSTI]

    Saenz, Christopher M

    2012-01-01

    Chronic stress has been linked to variation in gene regulation in the hippocampus (HIP) among other areas. These lead to cytoskeletal and volumetric rearrangements in various nuclei of the central nervous system and are ...

  10. A comparison of hepatitis B viral markers of patients in different clinical stages of chronic infection

    E-Print Network [OSTI]

    2010-01-01

    myrontong@hmri.org J. -H. Kao Hepatitis Research Center,CA, USA Abbreviations Anti-HBe Hepatitis B e antibody BCPcore promoter CH Chronic hepatitis HBsAg Hepatitis B surface

  11. An IL28B Genotype-Based Clinical Prediction Model for Treatment of Chronic Hepatitis C

    E-Print Network [OSTI]

    2011-01-01

    for Treatment of Chronic Hepatitis C Thomas R. O’Brien 1 *,statement on management of hepatitis C: 2002. NIH ConsensGlobal epidemiology of hepatitis C virus infection. Lancet

  12. Irreversible Pulmonary Hypertension Associated with the use of Interferon Alpha for Chronic Hepatitis C

    E-Print Network [OSTI]

    Dhillon, Sonu; Kaker, Anshul; Dosanjh, Aneil; Japra, Deepa; VanThiel, David H.

    2010-01-01

    of serum antibodies to hepatitis C virus. Am Rev Respir Dis.pulmonary ?brosis and hepatitis C virus infection. Am Revwith asthma and chronic hepatitis C. Mayo Clin Proc. 1999;

  13. A Model for Interprofessional Health Disparities Education: Student-Led Curriculum on Chronic Hepatitis B Infection

    E-Print Network [OSTI]

    Sheu, Leslie C.; Toy, Brian C.; Kwahk, Emanuel; Yu, Albert; Adler, Joshua; Lai, Cindy J.

    2010-01-01

    SK. Attitudes toward hepatitis B and liver cancer prevention11):1899–901. 37. Hu K. Hepatitis B Virus (HBV) infection inof persons with chronic hepatitis B virus infection. CDC

  14. Tactics of diabetes control: Turkish immigrant experiences with chronic illness in Berlin, Germany. 

    E-Print Network [OSTI]

    Guell, Cornelia

    2009-01-01

    This thesis explores Turkish migrants’ practices of diabetes care in Germany. Health statistics frequently identify minority groups as vulnerable to chronic illness and Turkish-origin Germans are said to be more likely ...

  15. The influence of contagion information and behavior on older adolescents' perceptions of peers with chronic illness 

    E-Print Network [OSTI]

    Grizzle, Jonhenry Cordell

    2005-11-01

    To explore attributions about chronically ill peers, 545 older adolescents ages 17-26 read a short vignette describing a brief social encounter with a hypothetical peer suffering from a medical condition, and then responded ...

  16. A Control Flow Prototype for a Dose Recommending Device for Chronic Myeloid Leukemia Patients

    E-Print Network [OSTI]

    De Micheli, Giovanni

    models of insulin infusion pump developed to ease the lifestyle of diabetic patients. The drug dose flow with a feedback of a potential infusion pump for Chronic Myeloid Leukemia patients

  17. Painted turtles (Chrysemys picta) may not flee earlier when chronically stressed

    E-Print Network [OSTI]

    Blouin-Demers, Gabriel

    1 Painted turtles (Chrysemys picta) may not flee earlier when chronically stressed By Sophia Reilly than those without such elevated levels of CORT (i.e. SHAM and control). Painted turtles (Chrysemys

  18. Infarct size and regional perfusion following coronary occlusion in the chronically sympathectomized canine ventricle 

    E-Print Network [OSTI]

    Beck, Linda Yvonne

    1978-01-01

    INFARCT SIZE AND REGIONAL PERFUSION FOLLOWING CORONARY OCCLUSION IN THE CHRONICALLY SYMPATHECTOMIZED CANINE VENTRICLE A Thesis by LINDA YVONNE BECK Submitted to the Graduate College of Texas A&M University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE May 1978 Major Sub)set: Biology INFARCT SIZE AND REGIONAL PERFUSION FOLLOWING CORONARY OCCLUSION IN THE CHRONICALLY SYMPATHECTOMIZED CANINE VENTRICLE A Thesis by LINDA YVONNE BECK Approved as to style...

  19. MAR 384 -DISEASES OF AQUATIC ORGANISMS (3 credits)

    E-Print Network [OSTI]

    Allam, Bassem

    . Disease management 26. Advances in aquatic animal disease Part I (vaccination, probiotics) 27. Advances

  20. Patching genes to fight disease

    SciTech Connect (OSTI)

    Holzman, D.

    1990-09-03

    The National Institutes of Health has approved the first gene therapy experiments, one of which will try to cure cancer by bolstering the immune system. The applications of such therapy are limited, but the potential aid to people with genetic diseases is great.

  1. Disease Management in Organic Plantings

    E-Print Network [OSTI]

    Isaacs, Rufus

    cooling or proper drying · Clean harvesting and processing equipment · Control insects that may createGard (Gliocladium virens) Blight Ban (Pseudomonas fluorescens) PlantShield (Trichoderma harzianum) Agri Antibiotics for control of bacterial diseases #12;Effect of Trichoderma hamatum (T382) in potting mix

  2. Easy Gardening.....Disease Control 

    E-Print Network [OSTI]

    Johnson, Jerral; Johnson, Jerral

    2009-05-29

    on plant roots and cause stunted plants. The most damaging nematode in the home garden is root knot. It causes galls or knots on susceptible plants such as toma- A good home gardener recognizes the symptoms of plant diseases quickly and takes steps...

  3. Social Cognition in Frontotemporal Dementia, Motor Neurone Disease, and Alzheimer's Disease 

    E-Print Network [OSTI]

    Oliver, Lindsay

    2011-11-23

    cognition across a number of neurodegenerative diseases, a test battery and two questionnaires were administered to frontal variant frontotemporal dementia (fvFTD), motor neurone disease (MND), Alzheimer`s disease, and healthy control participant groups...

  4. Why Do We Get Alzheimer's Disease?

    SciTech Connect (OSTI)

    Wyss-Coray, Tony (Stanford University) [Stanford University

    2006-01-02

    Neurodegenerative diseases and Alzheimer's disease (AD) in particular, are among the major health concerns of the elderly in industrialized societies. The cause of AD is unknown and no disease-modifying treatments are available. The disease is characterized clinically by a progressive dementia and pathologically by the accumulation of protein aggregates in the brain and a profound loss of nerve cells. It has also become clear recently that local immune responses are activated in the AD brain and may have a role in the disease. Our laboratory uses genetic mouse models to understand the disease process and to identify potential therapeutic targets.

  5. Development of a Vaccine for Bacterial Kidney Disease in Salmon, 1987 Annual Report.

    SciTech Connect (OSTI)

    Kaattari, Stephen

    1988-06-01

    Bacterial kidney disease (BKD) has been and remains a chronic contributory problem limiting the productivity of salmon in the Columbia River Basin. Control of this disease will not come easily, but it would lead to a tremendous increase in the health and numbers of salmon populations. Vaccination of salmon to Renibacterium salmoninarum (KDB) is a potentially successful method of controlling this disease. To date, however, no successful vaccine has been developed for general use. A possible solution to this problem, and thus the goal of this research, is to isolate the antigenic components of KDB and enhance their ability to activate the host defenses. This will be accomplished by the chemical modification of these antigens with potent immunomodulatory substances. These modified antigens will then be tested for their effectiveness in inducing immunity to BKD and thereby preventing the disease. The goal of the project's fourth year was to test the immunogenicity and prophylactic value in coho salmon (Oncorhynchus kisutch) of various--chemical conjugates of Renibacterium salmoninarum cell and major antigens. This was accomplished by assessing the serum antibody response, the cellular immune response (chemiluminescence), and the kinetics of mortality after lethal injections of the bacteria. The studies completed this year have: (1) identified immunization procedures which enhance the induction of high levels of antibody; (2) identified functionally distinct serum antibodies which may possess different abilities to protect salmon against BKD; (3) begun the isolation and characterization of anti-R. salmoninarum antibodies which may correlate with varying degrees of protection; (4) identified chemiluminescence as a potential method for assessing cellular immunity to bacterial kidney disease; and (5) characterized two monoclonal antibodies to R. salmoninarum which will be of benefit in the diagnosis of this disease.

  6. Demonstration of Advanced Technologies for Multi-Load Washers in Hospitality and Healthcare -- Ozone Based Laundry Systems

    SciTech Connect (OSTI)

    Boyd, Brian K.; Parker, Graham B.; Petersen, Joseph M.; Sullivan, Greg; Goetzler, W.; Sutherland, T. A.; Foley, K. J.

    2014-08-14

    The objective of this demonstration project was to evaluate market-ready retrofit technologies for reducing the energy and water use of multi-load washers in healthcare and hospitality facilities. Specifically, this project evaluated laundry wastewater recycling technology in the hospitality sector and ozone laundry technology in both the healthcare and hospitality sectors. This report documents the demonstration of ozone laundry system installations at the Charleston Place Hotel in Charleston, South Carolina, and the Rogerson House assisted living facility in Boston, Massachusetts.

  7. Development and Analytical Validation of an Enzyme-linked Immunosorbent Assay (ELISA) for the Measurement of Feline Alpha1-proteinase Inhibitor (fa1-PI) in Serum and Feces and the Evaluation of Fecal fa1-PI Concentrations in Cats with Idiopathic Inflammatory Bowel Disease or Gastrointestinal Neoplasia 

    E-Print Network [OSTI]

    Burke, Kathrin

    2012-10-19

    in feces and serum from cats, and, second, to evaluate fecal alpha1-PI concentrations in healthy cats and cats with chronic gastrointestinal disease. The lower detection limits of the ELISA were 0.02 g/L for serum and 0.04 microgram/gram for feces...

  8. Intermediate photovoltaic system application experiment operational performance report. Volume 3. For G. N. Wilcox Memorial Hospital, Kauai, Hawaii

    SciTech Connect (OSTI)

    Not Available

    1982-09-01

    Presented are the project description, list of participants, and system specifications for the intermediate photovoltaic project at G.N. Wilcox Memorial Hospital, Kauai, Hawaii.

  9. Technical Support Document: Development of the Advanced Energy Design Guide for Small Hospitals and Healthcare Facilities--30% Guide

    SciTech Connect (OSTI)

    Bonnema, E.; Doebber, I.; Pless, S.; Torcellini, P.

    2010-03-01

    This Technical Support Document describes the process and methodology for the development of the Advanced Energy Design Guide for Small Hospitals and Healthcare Facilities.

  10. Best Management Practices for Equine Disease Prevention 

    E-Print Network [OSTI]

    Scott, Brett D.

    2008-10-06

    AnimalDiseases,Revised1998] SchoolofVeterinaryMedicine,UniversityofWisconsin- Madison. Zoonotic Diseases Tutorial. www.vetmed.wisc.edu/pbs/zoonoses Hammer,Carolyn,2005, Equine Biological Risk Management.IowaStateUniversity. www.cfsph.iastate.edu Griffin...

  11. Karnal Bunt: A Disease of Wheat 

    E-Print Network [OSTI]

    Schuster, Greta; Krausz, Joseph P.; Rush, Charlie

    2002-11-20

    Karnal bunt is a fungal disease that affects wheat, durum wheat and triticale. This publication explains the life cycle of the disease, how it spreads, and methods of control....

  12. Does Drinking Tea Protect Against Cardiovascular Disease?

    E-Print Network [OSTI]

    Thompson, Natasha

    2003-01-01

    Maclure M, Muller JE et al. Tea consumption and mortalityU, Poole C, Arab L. Does Tea Affect Cardiovascular Disease?al. Regular Ingestion of black tea improves brachial artery

  13. New Clues in Predicting Alzheimer's Disease

    ScienceCinema (OSTI)

    Jagust, William

    2013-05-29

    Theres a new clue in the search to identify the harbingers of Alzheimers disease. More info: http://newscenter.lbl.gov/feature-stories/2008/12/16/predict-alzheimers-disease/

  14. MENINGOCOCCAL DISEASE WHAT YOU NEED TO KNOW

    E-Print Network [OSTI]

    Missouri-Rolla, University of

    , coughing and having close social contact (living in the same household) are examples of how this disease

  15. Exploratory Use of Microaerosol Decontamination Technology (PAEROSOL) in Enclosed, Unoccupied Hospital Setting

    SciTech Connect (OSTI)

    Rainina, Evguenia I.; McCune, D. E.; Luna, Maria L.; Cook, J. E.; Soltis, Michele A.; Demons, Samandra T.; Godoy-Kain, Patricia; Weston, J. H.

    2012-05-31

    The goal of this study was to validate the previously observed high biological kill performance of PAEROSOL, a semi-dry, micro-aerosol decontamination technology, against common HAI in a non-human subject trial within a hospital setting of Madigan Army Medical Center (MAMC) on Joint Base Lewis-McChord in Tacoma, Washington. In addition to validating the disinfecting efficacy of PAEROSOL, the objectives of the trial included a demonstration of PAEROSOL environmental safety, (i.e., impact to hospital interior materials and electronic equipment exposed during testing) and PAEROSOL parameters optimization for future deployment.

  16. Robot-assisted reaching exercise promotes arm movement recovery in chronic hemiparetic stroke: a randomized controlled pilot study

    E-Print Network [OSTI]

    Kahn, Leonard E; Zygman, Michele L; Rymer, W Zev; Reinkensmeyer, David J

    2006-01-01

    of robot assistance for arm movement therapy followingbased quan- tification of arm impairment following brainreaching exercise promotes arm movement recovery in chronic

  17. Biomarker for Lung and Inflammatory Diseases

    E-Print Network [OSTI]

    Heydari, Payam

    Biomarker for Lung and Inflammatory Diseases Tech ID: 23381 / UC Case 2012-660-0 BACKGROUND and clinical research. We describe herein a novel biomarker and method of detecting interstitial lung disease have discovered that patients with interstitial lung and intestinal inflammatory diseases, for example

  18. Linkage Disequilibrium Mapping and Parkinson's Disease

    E-Print Network [OSTI]

    Parkinson's Disease Genetics Study Group, Science 279, 1116 (1998); T. Lynch et al., ibid., 278, 1212 (1997Linkage Disequilibrium Mapping and Parkinson's Disease Several investigators (1) have questioned with Parkinson's disease (PD) in four appar- ently unrelated Italian and Greek families, may be a cause

  19. Akt Isoforms in Vascular Disease

    E-Print Network [OSTI]

    Yu, Haixiang; Littlewood, Trevor; Bennett, Martin

    2015-04-28

    aneurysm; eNOS, endothelial nitric oxide synthase;mTOR,mammalian target of rapamycin. 44 1223 331505. . This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). orms in vascular disease, Vascul. Pharmacol. (2015... p85 subunit and a catalytic p110 subunit that directly phosphorylates the ribosomal protein kinase p70s6k [29], the rho family polypeptide Rac [30], the serum and glucocorticoid-induced kinases SGK [31–33], and the serine/threonine kinase Akt [34...

  20. Diseases of Peaches and Plums. 

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01

    the possibility of root injury during cultivation as much as possible. Mushroom Root Rot Mushroom root rot is a fungal disease commonly known as "post oak root rot," "shoestring root rot" or "mushroom root rot." It attacks peach, pear, plum, apple and many... trees. Do not replant trees in old orchard sites infested with mushroom root rot. Cotton Root Rot Peach and plum trees die suddenly after show ing first symptoms of wilting. When roots are pulled from the soil, the bark is decayed, and covered...

  1. The effects of chronic and acute radiation upon the survival of C?H mice 

    E-Print Network [OSTI]

    Jones, Ernest Joseph

    1967-01-01

    THE EFFECTS OF CHRONIC AND ACUTE RADIATION UPON THE SURVIVAL OF C H MICE A Thesis By Ernest Joseph Jones Submitted to the Graduate College of the Texas A&M University in partial fulfillment of the requirements for the degree of MASTER... OF SCIENCE August 1967 Major Subject: Zoology (Physiology) THE EFFECTS OF CHRONIC AND ACUTE RADIATION UPON THE SURVIVAL OF C H MICE A Thesis By Ernest Joseph Jones Approved as to style and content by: hai of Committee) ( ber) (Head of Department...

  2. http://www.hsj.co.uk/ PCTs consider alternative to homeopathic hospitals

    E-Print Network [OSTI]

    Colquhoun, David

    in the NHS means we are seen as a soft target. #12;'We are funded by lots of small contracts Hospital is also experiencing a severe cut in funding, following the cancellation of contracts by commissioning PCTs. Contract terminated Brent PCT has terminated its contract with the Royal London

  3. Proceedings of the 2009 Industrial Engineering Research Conference Portable Equipment Management in Hospitals

    E-Print Network [OSTI]

    Rossetti, Manuel D.

    . Introduction Asset management is a critical part of a hospital's logistical operations. Large quantities categories: asset management, inventory management, authenticity management, identity management and process management [2]. The scope of this study falls into asset management, which involves tracking and managing

  4. Interactive Visualization of Hospital Contact Network Data on Multi-touch Displays

    E-Print Network [OSTI]

    Wyman, Chris

    in the United States every year. Understanding how infections spread in hospitals is critical to reducing of more than 100,000 people a year in the United States [2]. Epidemiologists are beginning to explore's research suggests the local water pump to be the origin of the epidemic [17]. Snow later plots the deaths

  5. The University of Iowa Hospitals and Clinics 200 Hawkins Drive, Iowa City, Iowa 52242-1009

    E-Print Network [OSTI]

    -mail: Hospital or Office Home 7. Country of Citizenship 8. If you are not a citizen of the United States orientation, gender identity, or associational preference. The University also affirms its commitment may review The University of Iowa Campus Security Policy and annual crime statistics by contacting

  6. Letter to the Editor : Rapidly-deployed small tent hospitals: lessons from the earthquake in Haiti.

    SciTech Connect (OSTI)

    Rosen, Y.; Gurman , P.; Verna, E.; Elman , N.; Labor, E. (Materials Science Division); (Superior NanoBioSystems LLC); (Fast Israeli Rescue & Search Team); (Clinique Adonai); (Mass. Inst. Tech.); (Univ. Haifa)

    2012-06-01

    The damage to medical facilities resulting form the January 2010 earthquake in haiti necessitated the establishment of field tent hospitals. Much of the local medical infrastructure was destroyed or limited operationally when the Fast Israel Rescue and Search Team (FIRST) arrived in Haiti shortly after the January 2010 earthquake. The FIRST deployed small tent hospitals in Port-au-Prince and in 11 remote areas outside of the city. Each tent was set up in less than a half hour. The tents were staffed with an orthopedic surgeon, gynecologists, primary care and emergency care physicians, a physician with previous experience in tropical medicine, nurses, paramedics, medics, and psychologists. The rapidly deployable and temporary nature of the effort allowed the team to treat and educate, as well as provide supplies for, thousands of refugees throughout Haiti. In addition, a local Haitian physician and his team created a small tent hospital to serve the Petion Refugee Camp and its environs. FIRST personnel also took shifts at this hospital.

  7. Acute poisoning is a common reason for visits to emergency departments and for hospitalization

    E-Print Network [OSTI]

    Bushman, Frederic

    ACUTE POISONING jUNE 2012, Issue 6 Acute poisoning is a common reason for visits to emergency departments and for hospitalization worldwide. The prevalence of acute poisoning in Southern Africa varies between 1 and 17%1 and available evidence from Botswana suggests that acute poisoning ranks third among

  8. Evaluation of AFBC co-firing of coal and hospital wastes

    SciTech Connect (OSTI)

    Not Available

    1991-02-01

    The purpose of this program is to expand the use of coal by utilizing CFB (circulating fluidized bed) technology to provide an environmentally safe method for disposing of waste materials. Hospitals are currently experiencing a waste management crisis. In many instances, they are no longer permitted to burn pathological and infectious wastes in incinerators. Older hospital incinerators are not capable of maintaining the stable temperatures and residence times necessary in order to completely destroy toxic substances before release into the atmosphere. In addition, the number of available landfills which can safely handle these substances is decreasing each year. The purpose of this project is to conduct necessary research investigating whether the combustion of the hospital wastes in a coal-fired circulating fluidized bed boiler will effectively destroy dioxins and other hazardous substances before release into the atmosphere. If this is proven feasible, in light of the quantity of hospital wastes generated each year, it would create a new market for coal -- possibly 50 million tons/year.

  9. OSU Veterinary Medicine Hospital The Equine Service of the OSU Veterinary Medical

    E-Print Network [OSTI]

    D student in the Department of Forensic Sciences at OSU-Tulsa. House Officer Seminars Two house officer Hospital. Lydia Gentry, DVM, will present "Using Cardiac Biomarkers in Small Animal Practice." Dr. Gentry is a Small Animal Medicine and Surgery Rotating Intern mentored by Dr. Ryan Baumwart. Allison Wilson, DVM

  10. Relating Weather Types to Asthma-Related Hospital Admissions in New York State

    E-Print Network [OSTI]

    Sheridan, Scott

    Relating Weather Types to Asthma-Related Hospital Admissions in New York State Cameron C. Lee,1 Scott C. Sheridan,1 and Shao Lin2 1 Kent State University, Kent, OH 2 New York State Department) throughout New York State. Results indicate that a cold and dry WT in autumn corresponds to increased asthma

  11. Recent Announcement for UW and Seattle Children's Hospital employees: Housing with no on-site childcare!

    E-Print Network [OSTI]

    Van Volkenburgh, Elizabeth

    before the general public. Background The University and Children's Hospital have a shared interest: Almost 40% of all faculty members who responded to the 2008 LCVI survey reported being impacted by a lack work-family conflict, and more men than women see the environment as supportive. But lest we think

  12. University of Texas Health Science Center at San Antonio Internal Medicine Residency Program, Doctors Hospital at Renaissance, Edinburg, Texas

    E-Print Network [OSTI]

    Nicholson, Bruce J.

    University of Texas Health Science Center at San Antonio Internal Medicine Residency Program, Doctors Hospital at Renaissance, Edinburg, Texas The University of Texas Health Science Center at San in the Internal Medicine Residency Program of the Doctors Hospital at Renaissance, Edinburg, Texas. This residency

  13. The diagnostic importance of photosensitivity dermatoses in chronic alcoholism: Report of two cases

    E-Print Network [OSTI]

    Pipili, Chrisoula; Cholongitas, Evangelos; Ioannidou, Despina

    2008-01-01

    complication of anorexia nervosa: a systematic review of theHartnup disease, anorexia nervosa [ 10 , 11 ], mycotoxins,

  14. : Catechin, green tea component, causes caspase independent necrosis-like cell death in chronic myelogenous leukemia

    E-Print Network [OSTI]

    Huang, Ching-Tsan

    : Catechin, green tea component, causes caspase independent necrosis-like cell death in chronic: 710­5. 2. Ahmad N, Feyes DK, Nieminen AL, Agarwal R, Mukhtar H. Green tea constituent epigallocatechin Inst, 1997. 89: 1881­6. 3. Nakazato T, Ito K, Miyakawa Y et al. Catechin, a green tea component

  15. Optimal Frequencies for Inductive Powering of Fully Implantable Biosensors for Chronic and Elderly

    E-Print Network [OSTI]

    De Micheli, Giovanni

    Optimal Frequencies for Inductive Powering of Fully Implantable Biosensors for Chronic and Elderly wirelessly to implanted biosensors. A system with an external transmitting coil located into a skin patch and a receiving coil embedded into a fully implanted biosensor is simulated. The effects of the geometry

  16. Neuropathic pain (NeP) is pain resulting from nervous tissue damage. It is chronic,

    E-Print Network [OSTI]

    Burn, Charlotte

    Why? Neuropathic pain (NeP) is pain resulting from nervous tissue damage. It is chronic, affects activity and quality of life. NeP is difficult to recognise in animals who can't report how they feel. We use clinical signs for diagnosis of Nep. However, we don't know if they are reliable. Sensory testing

  17. Evidence for metabolic imbalance of vitamin A2 in wild fish chronically exposed to metals

    E-Print Network [OSTI]

    Bernatchez, Louis

    Evidence for metabolic imbalance of vitamin A2 in wild fish chronically exposed to metals Michel A was observed. These results suggest that the enzymes and the binding proteins involved in vitamin A homeostasis are inhibited by the presence of Cd. Alternatively, the increase in tissue vitamin A (antioxidant) levels could

  18. Altered neurochemical levels in the rat brain following chronic nicotine Sara Falasca a

    E-Print Network [OSTI]

    Chronic nicotine Prefrontal cortex Dorsal striatum Hypothalamus A B S T R A C T Converging evidence shows as glutamate and gamma aminobutyric acid in the rat prefrontal cortex, dorsal striatum and hypothalamus. We of carnitine in the hypothalamus (26.59%, p

  19. Intelligent Agents for Rehabilitation and Care of Disabled and Chronic Patients Sarit Kraus

    E-Print Network [OSTI]

    Kraus, Sarit

    Intelligent Agents for Rehabilitation and Care of Disabled and Chronic Patients Sarit Kraus- ities with the rehabilitation and care necessary to al- low them good quality of life creates overwhelming de- mands for health and rehabilitation services. We sug- gest that advancements in intelligent

  20. Characterization of the Fecal Microbiota in Dogs with Chronic Enteropathies and Acute Hemorrhagic Diarrhea 

    E-Print Network [OSTI]

    Markel, Melissa

    2012-10-19

    of quantitative real-time PCR (qPCR) assays for the evaluation of specific bacterial groups in fecal samples of healthy dogs, dogs with chronic enteropathies (CE), and dogs with acute hemorrhagic diarrhea (AHD). Fecal samples from 242 healthy dogs, 118 dogs...

  1. Consistency of The Mortality of Chronically-irradiated Beagles with the Linear

    E-Print Network [OSTI]

    MacKay, David J.C.

    which radiation might be deemed to have negligible harm to most humans. Wade Allison also criticises-rates. These curves have been obtained from the beagle tissue archive1, which preserves the results of experiments in which hundreds of dogs were chronically exposed to gamma radiation for their entire lives Carnes

  2. ORIGINAL ARTICLE Chronic dim light at night provokes reversible depression-like

    E-Print Network [OSTI]

    Nelson, Randy J.

    .96; published online 24 July 2012 Keywords: BDNF; cytokine; hamster; hippocampus; light pollution; Phodopus in the United States and Europe experience nightly light pollution.8 Such unnatural conditions almost certainlyORIGINAL ARTICLE Chronic dim light at night provokes reversible depression-like phenotype: possible

  3. Chronic Citalopram Treatment Ameliorates Depressive Behavior Associated With Light at Night

    E-Print Network [OSTI]

    Nelson, Randy J.

    : light pollution, hippocampus, Phodopus sungorus, SSRI, circadian Exposure to light at night (LAN% of individuals living in the U.S. or Europe experience nightly light pollution (Navara & Nelson, 2007) and aboutChronic Citalopram Treatment Ameliorates Depressive Behavior Associated With Light at Night Tracy A

  4. Corpus Callosum Volume in Railroad Workers With Chronic Exposure to Solvents

    E-Print Network [OSTI]

    Corpus Callosum Volume in Railroad Workers With Chronic Exposure to Solvents Marc W. Haut, Ph reported after long-term exposure to solvents. Solvents are hypothesized to affect brain white matter to solvents. Methods: We manually traced (blind to group membership) the volume of the corpus callosum in 31

  5. Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia

    E-Print Network [OSTI]

    Chesler, Naomi C.

    Collagen-related gene and protein expression changes in the lung in response to chronic hypoxia changes in gene and protein expression in the lungs of mice exposed to hypoxia for 0, 3, 6, 10 and 15 days was increased in whole lungs as early as 6 days of hypoxia and increased monotonically with longer exposures

  6. Chronic rejection of a lung transplant is characterized by a profile of specific autoantibodies

    E-Print Network [OSTI]

    Domany, Eytan

    Chronic rejection of a lung transplant is characterized by a profile of specific autoantibodies Introduction Bronchiolitis obliterans syndrome (BOS) in lung trans- plant recipients is defined by progressive-term survival in lung transplant recipients2,3 and develops in nearly all patients to varying degrees.4

  7. Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice

    E-Print Network [OSTI]

    Sandini, Giulio

    Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine 5 September 2007 Available online 14 September 2007 Abstract We tested the role of sex chromosome complement and gonadal hormones in sex differences in several different paradigms measuring nociception

  8. Nature Methods Chronic in vivo imaging in the mouse spinal cord using an

    E-Print Network [OSTI]

    Schaffer, Chris B.

    the vertebral column and provided long-term optical access to the spinal cord. Supplementary Figure 2 A custom spinal chamber implant was mounted via a custom delivery system onto the vertebral column and provided to the ER90B right-angle adaptors. Shown mounted here is a vertebral clamp for acute imaging where a chronic

  9. A Wireless Neural Interface for Chronic Recording Reid R. Harrison1,2

    E-Print Network [OSTI]

    Shenoy, Krishna V.

    A Wireless Neural Interface for Chronic Recording Reid R. Harrison1,2 , Ryan J. Kier1 , Sohee Kim1 goal of the Integrated Neural Interface Project (INIP) is to develop a wireless, implantable device integrated circuit successfully recorded and wirelessly transmitted digitized electrical activity from

  10. Uncoupling at the GABA(A) receptor with chronic ethanol in the rat medial septum/diagonal band (MS/DB) 

    E-Print Network [OSTI]

    Wallace, Kathleen Allison

    1997-01-01

    allosteric potentiation of GABAAreceptors by a benzodiazepine, a novel anticonvulsant or a neurosteroid is uncoupled by chronic ethanol treatment which may contribute to functional tolerance and physical dependence. Chronic ethanol was not found to induce...

  11. Therapeutic target for protozoal diseases

    DOE Patents [OSTI]

    Rathore, Dharmendar (Blacksburg, VA); Jani, Dewal (Blacksburg, VA); Nagarkatti, Rana (Blacksburg, VA)

    2008-10-21

    A novel Fasciclin Related Adhesive Protein (FRAP) from Plasmodium and related parasites is provided as a target for therapeutic intervention in diseases caused by the parasites. FRAP has been shown to play a critical role in adhesion to, or invasion into, host cells by the parasite. Furthermore, FRAP catalyzes the neutralization of heme by the parasite, by promoting its polymerization into hemozoin. This invention provides methods and compositions for therapies based on the administration of protein, DNA or cell-based vaccines and/or antibodies based on FRAP, or antigenic epitopes of FRAP, either alone or in combination with other parasite antigens. Methods for the development of compounds that inhibit the catalytic activity of FRAP, and diagnostic and laboratory methods utilizing FRAP are also provided.

  12. Major Oak Diseases and Their Control. 

    E-Print Network [OSTI]

    Johnson, Jerral D.; Appel, David N.

    1984-01-01

    in many areas where oaks are the predominant native tree species. Research shows that much of this mortality is due to disease-causing organisms or disease complexes 10- volving environmental stress and pathogens. FOLIAR DISEASES Anthracnose (Fungus... tor nado, hurricane, severe hail or following a period of mechanical activity around oak trees. Heavy equip- ment working around trees can create large wounds. When this occurs, insects are attracted to the site and may be carrying the wilt...

  13. Diseases of Small Grains in Texas. 

    E-Print Network [OSTI]

    Atkins, I. M.; Futrell, M. C.

    1958-01-01

    Diseases - of SMALL GRAINS in cooperation with the UNITED STATES DEPARTMENT OF AGRICULTURE TEXAS AGRICULTURAL EXPERIMENT STATION R. D. LEWIS, DIRECTOR. COLLEGE STATIOKJ. TEXAS DIGEST CONTENTS 1 Diseases of small grains are important factors... and international signif- icance. The fall infection, winter survival and spring increase in South Texas of airborne pathogens, such as the cereal rusts, may endanger the small grain crops throughout Texas and other states. Diseases of wheat, which consistently...

  14. Mathematical Model Applications to Disease and Homeland ...

    E-Print Network [OSTI]

    Mathematical Model Applications to Disease and Homeland Security The events of ... but have no data or reliable information that would help in the planning or ...

  15. HANFORD THYROID DISEASE STUDY FINAL REPORT

    E-Print Network [OSTI]

    HANFORD THYROID DISEASE STUDY FINAL REPORT Study Management Team Scott Davis, Ph.D., Principal Gilman, Jennifer Sporleder, Jan Kikuchi, Bill Mullin, Liza Noonan, Chuck Wiggins, Belen Gallardo

  16. "Artificial" brains, electrical grids, and disease modeling:...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science discoveries unveiled "Artificial" brains, electrical grids, and disease modeling: Los Alamos science discoveries unveiled September 15 The event is an opportunity for...

  17. LED Surgical Task Lighting Scoping Study: A Hospital Energy Alliance Project

    SciTech Connect (OSTI)

    Tuenge, Jason R.

    2011-01-17

    Tungsten-halogen (halogen) lamps have traditionally been used to light surgical tasks in hospitals, even though they are in many respects ill-suited to the application due to the large percentage of radiant energy outside the visible spectrum and issues with color rendering/quality. Light-emitting diode (LED) technology offers potential for adjustable color and improved color rendition/quality, while simultaneously reducing side-effects from non-visible radiant energy. It also has the potential for significant energy savings, although this is a fairly narrow application in the larger commercial building energy use sector. Based on analysis of available products and Hospital Energy Alliance member interest, it is recommended that a product specification and field measurement procedure be developed for implementation in demonstration projects.

  18. Scoping Report: Advanced Technologies for Multi-Load Washers in Hospitality and Healthcare

    SciTech Connect (OSTI)

    Parker, Graham B.; Boyd, Brian K.; Petersen, Joseph M.; Goetzler, W.; Foley, K. J.; Sutherland, T. A.

    2013-03-27

    The purpose of this demonstration project is to quantify the energy savings and water efficiency potential of commercial laundry wastewater recycling systems and low-temperature detergent supply systems to help promote the adoption of these technologies in the commercial sector. This project will create a set of technical specifications for efficient multi-load laundry systems (both new and retrofit) tailored for specific applications and/or sectors (e.g., hospitality, health care). The specifications will be vetted with the appropriate Better Buildings Alliance (BBA) members (e.g., Commercial Real Estate Energy Alliance, Hospital Energy Alliance), finalized, published, and disseminated to enable widespread technology transfer in the industry and specifically among BBA partners.

  19. Development of design strategies to support evacuation process of hospital buildings in united states 

    E-Print Network [OSTI]

    Kader, Sharmin

    2009-05-15

    University of Engineering and Technology Co-Chairs of Advisory Committee: Dr. Ifte Choudhury Dr. Sarel Lavy The complete evacuation of hospital facilities is always a difficult and complex process. It has always been considered a last resort during any..., and ability to function during the evacuation. Among them, the evacuation warning time is the most important factor. For example, hurricanes and floods present threats that may allow some time for evacuation, but tsunamis allowing less time and earthquakes...

  20. SW SWGIBBS ST / SAM JACKSON PARK RD RDSW US VETERANS HOSPITAL RD

    E-Print Network [OSTI]

    Chapman, Michael S.

    BR B SW SWGIBBS ST / SAM JACKSON PARK RD SW SAM JACKSO N PARK RDSW US VETERANS HOSPITAL RD SW GAINES ST SW6THAVE SW CAMPUS DR SW USVETERANSHOSPITALRD SW CAM PUS DR SWTERWILLIGERBLVD 3 1 2 6 4 5 9 7 8.ohsu.edu/map From Lake Oswego/Sellwood Bridge area · Travel north on S.W. Macadam Ave. · Turn left onto S.W

  1. SW SWGIBBS ST / SAM JACKSON PARK RD RDSW US VETERANS HOSPITAL RD

    E-Print Network [OSTI]

    Chapman, Michael S.

    BR B B2 8 EM C SW SWGIBBS ST / SAM JACKSON PARK RD SW SAM JACKSO N PARK RDSW US VETERANS HOSPITAL RD SW GAINES ST SW6THAVE SW CAMPUS DR SW USVETERANSHOSPITALRD SW CAM PUS DR SWTERWILLIGERBLVD 3 1 2 6 HILL OHSU interactive map: www.ohsu.edu/map From Lake Oswego/Sellwood Bridge area · Travel north on S.W

  2. Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease

    SciTech Connect (OSTI)

    Lake, April D. [University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ 85721 (United States); Novak, Petr [Biology Centre ASCR, Institute of Plant Molecular Biology, Ceske Budejovice 37001 (Czech Republic); Shipkova, Petia; Aranibar, Nelly; Robertson, Donald; Reily, Michael D. [Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, NJ 08543 (United States); Lu, Zhenqiang [The Arizona Statistical Consulting Laboratory, University of Arizona, Tucson, AZ 85721 (United States); Lehman-McKeeman, Lois D. [Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, NJ 08543 (United States); Cherrington, Nathan J., E-mail: cherrington@pharmacy.arizona.edu [University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ 85721 (United States)

    2013-04-15

    Bile acids (BAs) have many physiological roles and exhibit both toxic and protective influences within the liver. Alterations in the BA profile may be the result of disease induced liver injury. Nonalcoholic fatty liver disease (NAFLD) is a prevalent form of chronic liver disease characterized by the pathophysiological progression from simple steatosis to nonalcoholic steatohepatitis (NASH). The hypothesis of this study is that the ‘classical’ (neutral) and ‘alternative’ (acidic) BA synthesis pathways are altered together with hepatic BA composition during progression of human NAFLD. This study employed the use of transcriptomic and metabolomic assays to study the hepatic toxicologic BA profile in progressive human NAFLD. Individual human liver samples diagnosed as normal, steatosis, and NASH were utilized in the assays. The transcriptomic analysis of 70 BA genes revealed an enrichment of downregulated BA metabolism and transcription factor/receptor genes in livers diagnosed as NASH. Increased mRNA expression of BAAT and CYP7B1 was observed in contrast to decreased CYP8B1 expression in NASH samples. The BA metabolomic profile of NASH livers exhibited an increase in taurine together with elevated levels of conjugated BA species, taurocholic acid (TCA) and taurodeoxycholic acid (TDCA). Conversely, cholic acid (CA) and glycodeoxycholic acid (GDCA) were decreased in NASH liver. These findings reveal a potential shift toward the alternative pathway of BA synthesis during NASH, mediated by increased mRNA and protein expression of CYP7B1. Overall, the transcriptomic changes of BA synthesis pathway enzymes together with altered hepatic BA composition signify an attempt by the liver to reduce hepatotoxicity during disease progression to NASH. - Highlights: ? Altered hepatic bile acid composition is observed in progressive NAFLD. ? Bile acid synthesis enzymes are transcriptionally altered in NASH livers. ? Increased levels of taurine and conjugated bile acids are observed in NASH. ? Hepatic bile acid synthesis shifts toward the alternative pathway in NASH.

  3. Disease management Applying Stylet Oil, Sulforix or

    E-Print Network [OSTI]

    Isaacs, Rufus

    1 Disease management Applying Stylet Oil, Sulforix or Armicarb now to vines with powdery mildew will reduce disease pressure next year. Do not apply Sulforix to sulfur-sensitive grapes. Bunch rots are best controlled by leaf pulling, but application of Fungastop may help reduce sour rot. Insect management Low

  4. What You Should Know About Plant Diseases

    E-Print Network [OSTI]

    Horne, C. Wendell; Smith, Harlan E.

    1962-01-01

    lodge, the grain is shrivelled and yields are low. The disease movement is shown in figure 6. " Seedling Disease ig. 7. See, caused b - -.-!.. ~. &> dling dise; y a comp' L , ase of cot1 lex of mic 11, *L^ -1. .fore its el tter it emf...

  5. Intermediate photovoltaic system application experiment operational performance report for G. N. Wilcox Memorial Hospital, Kauai, Hawaii, for November 1982

    SciTech Connect (OSTI)

    Not Available

    1982-01-01

    The data accumulated during November 1982 at the intermediate photovoltaic project at G.N. Wilcox Memorial Hospital, Kauai, Hawaii, are presented. Generated energy and environmental (weather) data are presented graphically. Explanations of irregularities not attributable to weather are provided.

  6. Oakwood Main Oakwood Main is a major teaching and research hospital and home to three medical residency

    E-Print Network [OSTI]

    Finley Jr., Russell L.

    Oakwood Main Oakwood Main is a major teaching and research hospital and home to three as one of the main teaching facilities for the Orthopaedic Program with the residents completing

  7. Comparison of LEED to Non-LEED Certified Hospitals with Regards to Patient Perspective and Financial Indicators 

    E-Print Network [OSTI]

    Ulusoy, Eren

    2012-10-19

    As natural resources are decreasing and environmental pollution is increasing, the buildings that play an important role in this problem should be constructed sustainably so their affects are kept to a minimum. Hospitals ...

  8. INCLEMENT WEATHER Residents/fellows are essential to the daily operation of each hospital and are expected to

    E-Print Network [OSTI]

    Page 140 ` INCLEMENT WEATHER Residents/fellows are essential to the daily operation of each hospital and are expected to report to work when scheduled. In the event of a severe weather condition

  9. Composition and production rate of pharmaceutical and chemical waste from Xanthi General Hospital in Greece

    SciTech Connect (OSTI)

    Voudrias, Evangelos; Goudakou, Lambrini; Kermenidou, Marianthi; Softa, Aikaterini

    2012-07-15

    Highlights: Black-Right-Pointing-Pointer We studied pharmaceutical and chemical waste production in a Greek hospital. Black-Right-Pointing-Pointer Pharmaceutical waste comprised 3.9% w/w of total hazardous medical waste. Black-Right-Pointing-Pointer Unit production rate for total pharmaceutical waste was 12.4 {+-} 3.90 g/patient/d. Black-Right-Pointing-Pointer Chemical waste comprised 1.8% w/w of total hazardous medical waste. Black-Right-Pointing-Pointer Unit production rate for total chemical waste was 5.8 {+-} 2.2 g/patient/d. - Abstract: The objective of this work was to determine the composition and production rates of pharmaceutical and chemical waste produced by Xanthi General Hospital in Greece (XGH). This information is important to design and cost management systems for pharmaceutical and chemical waste, for safety and health considerations and for assessing environmental impact. A total of 233 kg pharmaceutical and 110 kg chemical waste was collected, manually separated and weighed over a period of five working weeks. The total production of pharmaceutical waste comprised 3.9% w/w of the total hazardous medical waste produced by the hospital. Total pharmaceutical waste was classified in three categories, vial waste comprising 51.1%, syringe waste with 11.4% and intravenous therapy (IV) waste with 37.5% w/w of the total. Vial pharmaceutical waste only was further classified in six major categories: antibiotics, digestive system drugs, analgesics, hormones, circulatory system drugs and 'other'. Production data below are presented as average (standard deviation in parenthesis). The unit production rates for total pharmaceutical waste for the hospital were 12.4 (3.90) g/patient/d and 24.6 (7.48) g/bed/d. The respective unit production rates were: (1) for vial waste 6.4 (1.6) g/patient/d and 13 (2.6) g/bed/d, (2) for syringe waste 1.4 (0.4) g/patient/d and 2.8 (0.8) g/bed/d and (3) for IV waste 4.6 (3.0) g/patient/d and 9.2 (5.9) g/bed/d. Total chemical waste was classified in four categories, chemical reagents comprising 18.2%, solvents with 52.3%, dyes and tracers with 18.2% and solid waste with 11.4% w/w of the total. The total production of chemical waste comprised 1.8% w/w of the total hazardous medical waste produced by the hospital. Thus, the sum of pharmaceutical and chemical waste was 5.7% w/w of the total hazardous medical waste produced by the hospital. The unit production rates for total chemical waste for the hospital were 5.8 (2.2) g/patient/d and 1.1 (0.4) g/exam/d. The respective unit production rates were: (1) for reagents 1.7 (2.4) g/patient/d and 0.3 (0.4) g/examination/d, (2) for solvents 248 (127) g/patient/d and 192 (101) g/examination/d, (3) for dyes and tracers 4.7 (1.4) g/patient/d and 2.5 (0.9) g/examination/d and (4) for solid waste 54 (28) g/patient/d and 42 (22) g/examination/d.

  10. The effect of dietary supplements on chronic bitterweed (Hymenoxys odorata) poisoning in sheep 

    E-Print Network [OSTI]

    Post, Lynn Omer

    1982-01-01

    THE EFFECT OF DIETARY SUPPLEMENTS ON CHRONIC BITTERWEED (HYMENOXYS ODORATA) POISONING IN SHEEP A Thesis by LYNN OMER POST Submitted to the Graduate College of Texas A8M University in partial fulfillment of the requirement for the degree.... The immeasureable patience and constructive criticism of my committee chairman, Dr. E. M. Bailey, has been nothing but a positive influence in the completion of this investigation. Dr. L. P. Jones of the Texas Veterinary Medical Diagnostic Laboratory did an out...

  11. The implications of human metabolic network topology for disease comorbidity

    E-Print Network [OSTI]

    of different (and often disease-causing) genetic and epigenetic variations are not restricted but may spread, certain diseases, such as diabetes and obesity, or Gaucher disease and Parkinson disease, often cooccurThe implications of human metabolic network topology for disease comorbidity D.-S. Lee* , J. Park

  12. Improved Cognitive Function After Transcranial, Light-Emitting Diode Treatments in Chronic, Traumatic Brain Injury: Two Case Reports

    E-Print Network [OSTI]

    Naeser, Margaret A.

    Objective: Two chronic, traumatic brain injury (TBI) cases, where cognition improved following treatment with red and near-infrared light-emitting diodes (LEDs), applied transcranially to forehead and scalp areas, are ...

  13. Images of pain: Exploration of the characteristics and functions of pain-related mental imagery in chronic pain 

    E-Print Network [OSTI]

    Gosden, Thomas

    2008-01-01

    Introduction A recent study by Potter et al. (in submission) reported that many chronic pain sufferers experience a spontaneous mental image of their pain, and that these individuals also report higher levels of anxiety ...

  14. Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection

    E-Print Network [OSTI]

    Archary, Derseree

    Neutralizing (nAbs) and high affinity binding antibodies may be critical for an efficacious HIV-1 vaccine. We characterized virus-specific nAbs and binding antibody responses over 21 months in eight HIV-1 subtype C chronically ...

  15. A Semiautomated Framework for Integrating Expert Knowledge into Disease Marker Identification

    SciTech Connect (OSTI)

    Wang, Jing; Webb-Robertson, Bobbie-Jo M.; Matzke, Melissa M.; Varnum, Susan M.; Brown, Joseph N.; Riensche, Roderick M.; Adkins, Joshua N.; Jacobs, Jon M.; Hoidal, John R.; Scholand, Mary Beth; Pounds, Joel G.; Blackburn, Michael R.; Rodland, Karin D.; McDermott, Jason E.

    2013-10-01

    Background. The availability of large complex data sets generated by high throughput technologies has enabled the recent proliferation of disease biomarker studies. However, a recurring problem in deriving biological information from large data sets is how to best incorporate expert knowledge into the biomarker selection process. Objective. To develop a generalizable framework that can incorporate expert knowledge into data-driven processes in a semiautomated way while providing a metric for optimization in a biomarker selection scheme. Methods. The framework was implemented as a pipeline consisting of five components for the identification of signatures from integrated clustering (ISIC). Expert knowledge was integrated into the biomarker identification process using the combination of two distinct approaches; a distance-based clustering approach and an expert knowledge-driven functional selection. Results. The utility of the developed framework ISIC was demonstrated on proteomics data from a study of chronic obstructive pulmonary disease (COPD). Biomarker candidates were identified in a mouse model using ISIC and validated in a study of a human cohort. Conclusions. Expert knowledge can be introduced into a biomarker discovery process in different ways to enhance the robustness of selected marker candidates. Developing strategies for extracting orthogonal and robust features from large data sets increases the chances of success in biomarker identification.

  16. A Semiautomated Framework for Integrating Expert Knowledge into Disease Marker Identification

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wang, Jing; Webb-Robertson, Bobbie-Jo M.; Matzke, Melissa M.; Varnum, Susan M.; Brown, Joseph N.; Riensche, Roderick M.; Adkins, Joshua N.; Jacobs, Jon M.; Hoidal, John R.; Scholand, Mary Beth; et al

    2013-01-01

    Background . The availability of large complex data sets generated by high throughput technologies has enabled the recent proliferation of disease biomarker studies. However, a recurring problem in deriving biological information from large data sets is how to best incorporate expert knowledge into the biomarker selection process. Objective . To develop a generalizable framework that can incorporate expert knowledge into data-driven processes in a semiautomated way while providing a metric for optimization in a biomarker selection scheme. Methods . The framework was implemented as a pipeline consisting of five components for the identification of signatures from integrated clustering (ISIC).more »Expert knowledge was integrated into the biomarker identification process using the combination of two distinct approaches; a distance-based clustering approach and an expert knowledge-driven functional selection. Results . The utility of the developed framework ISIC was demonstrated on proteomics data from a study of chronic obstructive pulmonary disease (COPD). Biomarker candidates were identified in a mouse model using ISIC and validated in a study of a human cohort. Conclusions . Expert knowledge can be introduced into a biomarker discovery process in different ways to enhance the robustness of selected marker candidates. Developing strategies for extracting orthogonal and robust features from large data sets increases the chances of success in biomarker identification. « less

  17. Disease Prevention in the Home Garden. 

    E-Print Network [OSTI]

    Johnson, Jerral D.

    1980-01-01

    . 12. Rotation. Avoid soil disease buildup. ?13. Insect control. Prevent virus spread. 14. Proper harvesting. Avoid storage decay. 15. Sanitation. Prevent buildup of diseased plant tissue in garden. 16. Fungicide application. Control diseases should...H to approximately 5.2; 10 Ibs. of sulfur per 1000 sq . ft. d rops the pH .5. Examp le: Ori- ginal pH 7.5; desired pH 5.5; 40 Ibs. of sulfur requ ired to adjust pH 3. Ring rot Bacterium I nfected seed pieces Introduction of Rotation and sanitation Equipment...

  18. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general populationAging is the primary risk factor for the majority of neurodegenerative diseases, including

  19. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general population James Parkinson first described the clinical symptoms of Parkinson's disease (PD) in his 1817 monograph

  20. Aging is the primary risk factor for the majority of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million

    E-Print Network [OSTI]

    Liu, Taosheng

    Alzheimer's disease (AD) and Parkinson's disease (PD). There are almost 40 million people aged 65 and genetics that promote healthy aging will decrease the incidence of these diseases in the general population array of neurobiological disorders, including Parkinson's disease, epilepsy, essential tremor, Tourette

  1. Behavioral impulsivity and hallucinations : insights from Parkinson's disease

    E-Print Network [OSTI]

    Ashourian, Paymon

    2011-01-01

    Parkinson's disease (PD) is an age-related degenerative disease of the brain, characterized by motor, cognitive, and psychiatric symptoms. Neurologists and neuroscientists now understand that several symptoms of the disease, ...

  2. Study of collagen structure in canine myxomatous mitral valve disease 

    E-Print Network [OSTI]

    Hadian, Mojtaba

    2009-01-01

    Myxomatous mitral valve disease (MMVD) is the single most common acquired cardiac disease of dogs, and is a disease of significant veterinary importance. It also bears close similarities to mitral valve prolapse in humans ...

  3. Epidemiology and evolution of Marek’s Disease virus 

    E-Print Network [OSTI]

    Atkins, Katherine E.

    2010-01-01

    Marek’s disease (MD) is an oncogenic disease affecting chickens and is estimated to cost the worldwide poultry industry $1-2 billion annually. The causative agent of MD, Marek’s disease virus (MDV), provides a ...

  4. HLB in Argentina: a New Disease Outbreak

    E-Print Network [OSTI]

    2014-01-01

    Vol. 1 (2014) HLB in Argentina: a New Disease Outbreak Outi,E. 6 SENASA, Bs. As. Argentina MAGyP Bs. As INTA Montecarlo,Paraná, 300 km away from Argentina’s Northeastern border. In

  5. Metabolomics reveals metabolic biomarkers of Crohn's disease

    SciTech Connect (OSTI)

    Jansson, J.K.; Willing, B.; Lucio, M.; Fekete, A.; Dicksved, J.; Halfvarson, J.; Tysk, C.; Schmitt-Kopplin, P.

    2009-06-01

    The causes and etiology of Crohn's disease (CD) are currently unknown although both host genetics and environmental factors play a role. Here we used non-targeted metabolic profiling to determine the contribution of metabolites produced by the gut microbiota towards disease status of the host. Ion Cyclotron Resonance Fourier Transform Mass Spectrometry (ICR-FT/MS) was used to discern the masses of thousands of metabolites in fecal samples collected from 17 identical twin pairs, including healthy individuals and those with CD. Pathways with differentiating metabolites included those involved in the metabolism and or synthesis of amino acids, fatty acids, bile acids and arachidonic acid. Several metabolites were positively or negatively correlated to the disease phenotype and to specific microbes previously characterized in the same samples. Our data reveal novel differentiating metabolites for CD that may provide diagnostic biomarkers and/or monitoring tools as well as insight into potential targets for disease therapy and prevention.

  6. Management of cotton seedling disease complexes 

    E-Print Network [OSTI]

    Fichtner, Scott Michael

    2001-01-01

    The objective of this research was to evaluate combinations of approaches for the management of seedling diseases of cotton caused by soilborne pathogens, including the use of host resistance. Over 200 cotton lines were ...

  7. MFR PAPER 1208 Minchinia nelsoni (MSX) Disease

    E-Print Network [OSTI]

    of the disease in each of these areas has been thoroughly stud- 22 ied and reported (Haskin et aI., 1965; Andrews, 1966, 1968; Rosenfield and Sindermann, 1966; Andrews and Wood, 1967; Couch and Rosenfield, 1968; Ford

  8. Is chytridiomycosis an emerging disease in Asia?

    E-Print Network [OSTI]

    Brown, Rafe M.

    2011-01-01

    Museum of Natural Sciences, Raleigh, North Carolina, United States of America, 26Museo Nacional de Ciencias Naturales, Madrid, Spain Abstract The disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has caused dramatic... Museum of Natural Sciences, Raleigh, North Carolina, United States of America, 26Museo Nacional de Ciencias Naturales, Madrid, Spain Abstract The disease chytridiomycosis, caused by the fungus Batrachochytrium dendrobatidis (Bd), has caused dramatic...

  9. Molecular pathogenesis of Helicobacter hepaticus induced liver disease

    E-Print Network [OSTI]

    Boutin, Samuel R., 1952-

    2005-01-01

    Helicobacter hepaticus infection of A/JCr mice is a model of liver cancer resulting from chronic active inflammation. We monitored hepatic global gene expression profiles and correlated them to histological liver lesions ...

  10. Determinants of the creatinine clearance to glomerular filtration rate ratio in patients with chronic kidney disease: a cross-sectional study

    E-Print Network [OSTI]

    Lin, Yen-chung; Bansal, Nisha; Vittinghoff, Eric; Go, Alan S; Hsu, Chi-yuan

    2013-01-01

    and Bauer measured GFR using inulin clearance rather thancardiac failure (and mean inulin clearance of 47 ml/min/1.73with nephrotic syndrome (and mean inulin clearance of 42 ml/

  11. Characterisation of a mouse model of chronic cerebral hypoperfusion and its application to investigating the impact of hypoperfusion on the development of Alzheimer’s disease 

    E-Print Network [OSTI]

    Coltman, Robin Bruce

    2012-06-22

    The integrity of brain white matter is vital for the interneuronal signalling between distinct brain regions required for normal cognitive function. White matter integrity is compromised with ageing and could contribute ...

  12. Hyperphosphatemia is associated with anemia in adults without chronic kidney disease: results from the National Health and Nutrition Examination Survey (NHANES): 2005¿2009

    E-Print Network [OSTI]

    Wojcicki, Janet M

    2013-01-01

    Dai Q: Renal function, bisphenol A and alkylphenols: resultsphenols (specifically bisphenol A (BPA) and triclosan) wereenvironmental phenols (bisphenol A (BPA), benzo- pheonone-

  13. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

    E-Print Network [OSTI]

    Aminzadeh, MA; Reisman, SA; Vaziri, ND; Khazaeli, M; Yuan, J; Meyer, CJ

    2014-01-01

    Subramanian S. (2011). Resveratrol protects diabetic kidneyepigallocatechin-3-gallate, resveratrol, antro- quinonol and

  14. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease

    E-Print Network [OSTI]

    2013-01-01

    R. de Cabo, A. Csiszar, Resveratrol confers endothelialstress. For example, resveratrol, a phytochemical with weak

  15. Major prime contractors have developed a plan to address Hanford Beryllium exposure and are continuing to improve the Chronic Beryllium Disease Prevention Plan (CBDPP)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverseIMPACTThousandReport)Price (Dollars per ThousandMajor New MexicoCOLUMBIA

  16. An investigation of factors associated with psychiatric hospital admission despite the presence of crisis resolution teams

    E-Print Network [OSTI]

    Cotton, Mary-Anne; Johnson, Sonia; Bindman, Jonathan; Sandor, Andrew; White, Ian R; Thornicroft, Graham; Nolan, Fiona; Pilling, Stephen; Hoult, John; McKenzie, Nigel; Bebbington, Paul

    2007-10-02

    admission rates. Two stud- ies, one naturalistic and one a randomised controlled trial, have investigated outcomes of CRT care in Islington, London [7,8]. Both showed a significant reduction in hos- pital admissions at 8 weeks and 6 weeks respectively... Cri- sis Assessment and Treatment Team. Psychiatric Bulletin 2001, 25:439-441. 4. Stein L, Hoult J, Dean C, Wood S, Muijen M, Marks IM, Connolly J, Falloon IRH, Graham HV: Home treatment. In The closure of men- tal hospitals Edited by: Hall P...

  17. Geothermal heating project at St. Mary's Hospital, Pierre, South Dakota. Final report

    SciTech Connect (OSTI)

    Not Available

    1984-12-01

    St. Mary's Hospital, Pierre, South Dakota, with the assistance of the US Department of Energy, drilled a 2176 ft well into the Madison Aquifer ot secure 108/sup 0/F artesian flow water at 385 gpm (475 psig shut-in pressure). The objective was to provide heat for domestic hot water and to space heat 163,768 sq. ft. Cost savings for the first three years were significant and, with the exception of a shutdown to replace some corroded pipe, the system has operated reliably and continuously for the last four years.

  18. Continuous Commissioning of the Reynolds Army Community Hospital, Fort Sill, Oklahoma 

    E-Print Network [OSTI]

    Turner, W. D.; Baltazar-Cervantes, J. C.; Martinez, J. T.

    2007-01-01

    RA Damper H C C C MAT PHT RAT RAH SAT Return air Supply air OA Damper Relief Damper Preheat Valve Chilled Water Valve * Steam Humidifier Valve * Steam Humidifier is only present on hospital side Figure 1: AHU Schematic There was limited... If the supply temperature is increased above 58°F hot spots will develop throughout the area. These hot spot areas govern the high limit on the supply air temperature reset. Therefore, when the outside air temperature is 40°F the supply air temperature...

  19. Oregon Hospital Heats Up with a Biomass Boiler | Department of Energy

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesseworkSURVEYI/O Streams for Large-scale ScientificOregon Hospital Heats Up

  20. How should environmental stress affect the population dynamics of disease?

    E-Print Network [OSTI]

    Holt, Robert D.

    in pollution (Khan 1990), malnutrition (Beck & Levander 2000) and thermal stress from climate change (Harvell and disease in natural populations. Keywords Disease, dynamics, host, infectious, model, pollution, population

  1. Disease-Specific Symptoms and Health-Related Quality of Life in Children and Adolescents with Inflammatory Bowel Disease 

    E-Print Network [OSTI]

    Vaughan-Dark, Chelsea Ann

    2013-07-17

    This study assesses generic and disease-specific Health-Related Quality of Life (HRQOL) in children and adolescents with Inflammatory Bowel Disease (IBD). More specifically, the purpose of the study is to address the relationship between disease...

  2. Discovery of Disease Co-occurrence Patterns from Electronic Healthcare Reimbursement Claims Data

    SciTech Connect (OSTI)

    Ramanathan, Arvind; Pullum, Laura L; Hobson, Tanner C; Quinn, Shannon; Chennubhotla, Chakra; Valkova, Silvia

    2014-01-01

    Effective public health surveillance is important for national secu- rity. With novel emerging infectious diseases being reported across different parts of the world, there is a need to build effective bio- surveillance systems that can track, monitor and report such events in a timely manner. Additionally, there is a need to identify sus- ceptible geographic regions/populations where these diseases may have a significant impact and design preemptive strategies to tackle them. With the digitization of health related information through electronic health records (EHR) and electronic healthcare claim re- imbursements (eHCR), there is a tremendous opportunity to ex- ploit these datasets for public health surveillance. In this paper, we present our analysis on the use of eHCR data for bio-surveillance by studying the 2009-2010 H1N1 pandemic flu season. We present a novel approach to extract spatial and temporal patterns of flu in- cidence across the United States (US) from eHCRs and find that a small, but distinct set of break-out patterns govern the flu and asthma incidence rates across the entire country. Further, we ob- serve a distinct temporal lag in the onset of flu when compared to asthma across geographic regions in the US. The patterns extracted from the data collectively indicate how these break-out patterns are coupled, even though the flu represents an infectious disease whereas asthma represents a typical chronic condition. Taken to- gether, our approach demonstrates how mining eHCRs can provide novel insights in tackling public health concerns.

  3. Photo-environment affects disease progression in bacterial artificial chromosome (BAC) Huntington s disease mouse model

    E-Print Network [OSTI]

    HUEI-BIN, WANG,

    2015-01-01

    OF CALIFORNIA Los Angeles Photo-environment affects diseaseABSTRACT OF THE THESIS Photo-environment affects diseaseshow that inappropriate photo-environment such as constant

  4. UPLC-based metabonomic applications for discovering biomarkers of diseases in clinical chemistry

    E-Print Network [OSTI]

    Zhao, YY; Cheng, XL; Vaziri, ND; Liu, S; Lin, RC

    2015-01-01

    cancer . . . . . . . .Ovarian cancer . . . . . . . Chronicbiomarker for epithelium ovarian cancer. J Proteome Res [73]tract (prostate cancer, ovarian cancer and chronic kidney

  5. AFBC co-firing of coal and hospital waste. Quarterly report, August--October 1995

    SciTech Connect (OSTI)

    Stuart, J.M.

    1996-03-01

    The project objective is to design, construct, install provide operator training and start-up a circulating fluidized bed combustion system at the Lebanon Pennsylvania Veteran`s Affairs Medical Center. This unit will co-fire coal and hospital waste providing lower cost steam for heating and possibly cooling (absorption chiller) and operation of a steam turbine-generator for limited power generation. This would permit full capacity operation of the FBC year round in spite of the VA laundry that was shut down as well as efficient destruction of both general and infectious hospital waste and steam generation. The State permitting process required for construction will be completed in early November to allow installation and construction to be completed. Operating permits will be obtained after construction has been completed. A request for proposal for stack sampling and biospore tests was released to four (4) vendors in mid-October. The proposals shall be reviewed during November and the stack sampler will be selected. Funding was approved as of August 1, 1995. Construction and installation resumed on August 21, 1995 at the LVAMC. Construction and installation continues and will be completed by late December 1995.

  6. Original Article Detection of Minimal Residual Disease in B

    E-Print Network [OSTI]

    Pe'er, Dana

    contemporary risk-adapted therapeutic protocols (3,4). Two principal methodologies have been used to detect MRDGiuseppe, Department of Pathol- ogy & Laboratory Medicine, Hartford Hospital, 80 Seymour St Hart- ford, CT 06102

  7. Neurobiology of Disease PDZ Protein Interactions Underlying NMDA Receptor-

    E-Print Network [OSTI]

    Rabinowitz, Joshua D.

    ., Toronto, Ontario, Canada M8X 1R5, 4Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada C1A 4P3, 5Programme in Brain and Behaviour, Hospital for Sick

  8. Global disease monitoring and forecasting with Wikipedia

    SciTech Connect (OSTI)

    Generous, Nicholas; Fairchild, Geoffrey; Deshpande, Alina; Del Valle, Sara Y.; Priedhorsky, Reid; Salathé, Marcel

    2014-11-13

    Infectious disease is a leading threat to public health, economic stability, and other key social structures. Efforts to mitigate these impacts depend on accurate and timely monitoring to measure the risk and progress of disease. Traditional, biologically-focused monitoring techniques are accurate but costly and slow; in response, new techniques based on social internet data, such as social media and search queries, are emerging. These efforts are promising, but important challenges in the areas of scientific peer review, breadth of diseases and countries, and forecasting hamper their operational usefulness. We examine a freely available, open data source for this use: access logs from the online encyclopedia Wikipedia. Using linear models, language as a proxy for location, and a systematic yet simple article selection procedure, we tested 14 location-disease combinations and demonstrate that these data feasibly support an approach that overcomes these challenges. Specifically, our proof-of-concept yields models with up to 0.92, forecasting value up to the 28 days tested, and several pairs of models similar enough to suggest that transferring models from one location to another without re-training is feasible. Based on these preliminary results, we close with a research agenda designed to overcome these challenges and produce a disease monitoring and forecasting system that is significantly more effective, robust, and globally comprehensive than the current state of the art.

  9. Global disease monitoring and forecasting with Wikipedia

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Generous, Nicholas; Fairchild, Geoffrey; Deshpande, Alina; Del Valle, Sara Y.; Priedhorsky, Reid; Salathé, Marcel

    2014-11-13

    Infectious disease is a leading threat to public health, economic stability, and other key social structures. Efforts to mitigate these impacts depend on accurate and timely monitoring to measure the risk and progress of disease. Traditional, biologically-focused monitoring techniques are accurate but costly and slow; in response, new techniques based on social internet data, such as social media and search queries, are emerging. These efforts are promising, but important challenges in the areas of scientific peer review, breadth of diseases and countries, and forecasting hamper their operational usefulness. We examine a freely available, open data source for this use: accessmore »logs from the online encyclopedia Wikipedia. Using linear models, language as a proxy for location, and a systematic yet simple article selection procedure, we tested 14 location-disease combinations and demonstrate that these data feasibly support an approach that overcomes these challenges. Specifically, our proof-of-concept yields models with up to 0.92, forecasting value up to the 28 days tested, and several pairs of models similar enough to suggest that transferring models from one location to another without re-training is feasible. Based on these preliminary results, we close with a research agenda designed to overcome these challenges and produce a disease monitoring and forecasting system that is significantly more effective, robust, and globally comprehensive than the current state of the art.« less

  10. Impact of current health care reform proposals on people with chronic illnesses

    E-Print Network [OSTI]

    Hall, Jean P.; Moore, Janice M.; Otto, B.; Salley, S.

    2009-11-07

    For more information, contact Barbara Otto, HDA, 312-265-9090 or go to www.hdadvocates.org 1 Impact of Current Health Care Reform Proposals on People with Chronic Illnesses November 7, 2009 State high-risk insurance pools serve people... who have been denied coverage because of pre- existing conditions or who don’t have access to employer based coverage. There are 35 state high-risk insurance pools across the country serving approximately 200,000 people. The U.S. Congress...

  11. Chronic cellular responses of rat skin to 13 Mev proton irradiation 

    E-Print Network [OSTI]

    Hinkle, Donald King

    1966-01-01

    irradiated in a total of six rad groups as follows: Number in Grou dD 10 6 9 6 7 8 ZOO 400 700 1300 2000 2500 All sections of skin and tumor tissues were submitted to the Anatomic Pathology Section, USAF School of Aerospace Medicine...CHRONIC CELLULAR RESPONSES OF RAT SKIN TO 13 MEV PROTON IRRADIATION A Thesis by DONALD KING HINKLE, D. V. M. Submitted to the Graduate College of the Texas AErM University in partial fulfillment of the requirements for the degree of MASTER...

  12. 788 Plant Disease / Vol. 83 No. 9 Snow mold diseases are caused by fungi

    E-Print Network [OSTI]

    Hsiang, Tom

    788 Plant Disease / Vol. 83 No. 9 Snow mold diseases are caused by fungi that grow and attack limit the activity and number of com- petitors and antagonists of snow mold fungi, and allow these pathogens to mo- nopolize the nutrient-rich but weakened plant tissues (42). Most snow mold fungi that have

  13. ACCORDING TO Welcome to our first

    E-Print Network [OSTI]

    Huang, Wei

    in chronic hospitals. About 5 million patients develop pressure ulcers annually in the United States against heart disease and cancer, the two leading causes of death in the nation. With the Whitaker grant rates of people undergoing angioplasty. "Our goal is to make a difference," Skalak observes. "And

  14. Elevated expression of ERK 2 in human tumor cells chronically treated with PD98059

    SciTech Connect (OSTI)

    Kanda, Shigeru [Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki University Graduate School of Biomedical Science, Nagasaki (Japan)]. E-mail: skanda-jua@umin.net; Kanetake, Hiroshi [Department of Urology, Nagasaki University Graduate School of Biomedical Science, Nagasaki (Japan); Miyata, Yasuyoshi [Department of Urology, Nagasaki University Graduate School of Biomedical Science, Nagasaki (Japan)

    2006-07-14

    We examined the effect of chronic exposure of tumor cells to a mitogen-activated protein kinase/extracellular signal-regulated kinases (ERK) kinase inhibitor, PD98059, on cell proliferation was investigated. Human renal carcinoma cells (ACHN) and prostatic carcinoma cells (DU145) were cultured in the presence of PD98059 for more than 4 weeks (denoted ACHN (PD) cells and DU145 (PD) cells, respectively) and proliferation and signal transduction pathways were examined. PD98059 significantly inhibited the proliferation of parental cells. However, PD98059 failed to inhibit proliferation of ACHN (PD) and DU145 (PD) cells significantly. Expression of ERK 1 and 2 was elevated in these cells. These phenotypes were reversible. Downregulation of ERK 2, but not ERK 1, by small interfering RNA significantly inhibited the proliferation of ACHN (PD) and DU145 (PD) cells. Taken together, chronic exposure of tumor cells to PD98059 induced elevated expression of ERK 2, which was associated with decreased sensitivity of cellular proliferation to PD98059.

  15. Status report on a solar photovoltaic concentrating energy system for a hospital in Hawaii

    SciTech Connect (OSTI)

    Seki, A.; Curtis, G.; Yuen, P.

    1983-06-01

    The largest parabolic concentrating photovoltaic/solar thermal system in the U.S. began producing electricity and hot water for a hospital on the island of Kauai, Hawaii in November 1981. Each of the 80 parabolic collectors is 6 feet by 10 feet and concentrates incident sunlight on photovoltaic cells mounted on two faces of the receiver at the focus. Although the 35 kilowatt system has been designed to produce 22,000 net kilowatt-hours per year of electricity and 620,000 gallons of 180 F water, electrical output (12 to 15 kilowatt-hours per day) is only 20 percent of that expected, primarily because insolation at the site has been only 40 percent of predicted values. A second problem with fungal attack on the receivers has been solved by better sealing. The system has also withstood a hurricane with negligible damage.

  16. Health Information Technology in US Hospitals: Analysis of Current Status and Development of Future Strategies 

    E-Print Network [OSTI]

    Kim, Jungyeon

    2015-06-01

    s t ha t s up po rt EH R a pp lic at io ns ? *4 D oe s t he h os pi ta l C hi ef In fo rm at io n O ff ic er (C IO ) h av e re sp on si bi lit y fo r H ea lth In fo rm at io n M an ag em en t ( H IM )? 16 17 Hospitals’ past experience with IE... R at io o f I S FT Es to to ta l F TE s 97 3 1. 00 4 (1 .0 00 3- 1. 00 70 ) 0. 03 1 62 5 1. 00 6 (1 .0 00 7- 1. 01 16 ) 0. 02 7 FT Es su pp or tin g EH R a pp lic at io ns *1 83 3 1. 51 (1 .0 6- 2. 17 ) 0. 02 4 62 5 1. 46 (0...

  17. interdisciplinary Glyphosate, pathways to modern diseases II

    E-Print Network [OSTI]

    Seneff, Stephanie

    rashes, depression, and nutrient deficiencies. Usually, but not always, a strict gluten-free diet caninterdisciplinary Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North

  18. ISSUE 58 APRIL 2009 Will coeliac disease

    E-Print Network [OSTI]

    Rambaut, Andrew

    ISSUE 58 APRIL 2009 Will coeliac disease always mean gluten-free? Pen-pushers Meet the winning is to deliver a free, Darwin-inspired experiment to every schoolchild in the country. For primary schools, we of the Wellcome Trust Wellcome News Wellcome News is published four times a year and is available free of charge

  19. Centers for Disease Control and Prevention (CDC)

    E-Print Network [OSTI]

    and Terrorism and Director of Global Health Activities for the Division of Environmental Hazards and Health based environmental health assessments #12;Government Agencies Visited · The United States AgencyCenters for Disease Control and Prevention (CDC) National Center for Environmental Health CDC

  20. DISEASE-SPECIFIC PROBABILISTIC BRAIN ATLASES

    E-Print Network [OSTI]

    Thompson, Paul

    algorithms for knowledge-based image analysis, automated image labeling, tissue classification, data mining School of Medicine, Los Angeles, CA 2 Alzheimer's Disease Center, UCLA School of Medicine, Los Angeles Westwood Plaza, Los Angeles, CA 90095-1769 Phone: (310) 206-2101 Fax: (310) 206-5518 E-mail: thompson

  1. Injury vs Disease Lifestyles of pathogens

    E-Print Network [OSTI]

    Nowak, Robert S.

    of plant disease Nematodes alone cost ~$100 billions worldwide In the US, yearly cost ~ $15 billions #12 of temperature 3 Days After #12;#12;Effects of wind Mostly dispersal of pathogens In some cases, wind can prevent the development of new infections because it dries the surface of plants Wind can cause injury

  2. Injury vs Disease Lifestyles of pathogens

    E-Print Network [OSTI]

    Nowak, Robert S.

    In the US, yearly cost ~ $15 billions #12;4/29/2015 15 Impacts of plant disease In a worldwide scale 27 of wind Mostly dispersal of pathogens In some cases, wind can prevent the development of new infections because it dries the surface of plants Wind can cause injury (mechanical abrasion) Effects of temperature

  3. 3301DEVELOPMENT AND DISEASE RESEARCH ARTICLE INTRODUCTION

    E-Print Network [OSTI]

    Gibson, Matt

    smooth muscle cells (SMC) and SM pathology is associated with several diseases, including asthma, lung the urinary bladder, and a failure of this activity causes `functional' flow impairment leading to urinary tract may be an important primary cause of functional obstruction and hydronephrosis. Between mouse

  4. Treatment of Anthrax Disease Frequently Asked Questions

    SciTech Connect (OSTI)

    Judd, Kathleen S.; Young, Joan E.; Lesperance, Ann M.; Malone, John D.

    2010-05-14

    This document provides a summary of Frequently Asked Questions (FAQs) on the treatment of anthrax disease caused by a wide-area release of Bacillus anthracis spores as an act bioterrorism. These FAQs are intended to provide the public health and medical community, as well as others, with guidance and communications to support the response and long-term recovery from an anthrax event.

  5. ISSUE 55 JULY 2008 Genes and disease

    E-Print Network [OSTI]

    Rambaut, Andrew

    ISSUE 55 JULY 2008 FUNDING Genes and disease In this issue... FUNDING AND UPDATES 2­5 Project building, in Kenya, South Africa, Uganda and elsewhere in Africa (see page 5). The largest ever study. The Institute will devote a large part of its high-throughput genotyping pipeline, headed by Dr Panos Deloukas

  6. DISEASES OF AQUATIC ORGANISMS Dis Aquat Org

    E-Print Network [OSTI]

    Harvell, Catherine Drew

    and disease in Mexico J. R. Ward1,*, K. L. Rypien1 , J. F. Bruno2 , C. D. Harvell1 , E. Jordán-Dahlgren3 , K Sciences, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3300, USA 3

  7. Disease Prediction Models and Operational Readiness

    SciTech Connect (OSTI)

    Corley, Courtney D.; Pullum, Laura L.; Hartley, David M.; Benedum, Corey M.; Noonan, Christine F.; Rabinowitz, Peter M.; Lancaster, Mary J.

    2014-03-19

    INTRODUCTION: The objective of this manuscript is to present a systematic review of biosurveillance models that operate on select agents and can forecast the occurrence of a disease event. One of the primary goals of this research was to characterize the viability of biosurveillance models to provide operationally relevant information for decision makers to identify areas for future research. Two critical characteristics differentiate this work from other infectious disease modeling reviews. First, we reviewed models that attempted to predict the disease event, not merely its transmission dynamics. Second, we considered models involving pathogens of concern as determined by the US National Select Agent Registry (as of June 2011). Methods: We searched dozens of commercial and government databases and harvested Google search results for eligible models utilizing terms and phrases provided by public health analysts relating to biosurveillance, remote sensing, risk assessments, spatial epidemiology, and ecological niche-modeling, The publication date of search results returned are bound by the dates of coverage of each database and the date in which the search was performed, however all searching was completed by December 31, 2010. This returned 13,767 webpages and 12,152 citations. After de-duplication and removal of extraneous material, a core collection of 6,503 items was established and these publications along with their abstracts are presented in a semantic wiki at http://BioCat.pnnl.gov. Next, PNNL’s IN-SPIRE visual analytics software was used to cross-correlate these publications with the definition for a biosurveillance model resulting in the selection of 54 documents that matched the criteria resulting Ten of these documents, However, dealt purely with disease spread models, inactivation of bacteria, or the modeling of human immune system responses to pathogens rather than predicting disease events. As a result, we systematically reviewed 44 papers and the results are presented in this analysis.

  8. Intermediate photovoltaic system application experiment operational performance report, for G. N. Wilcox Memorial Hospital, Kauai, Hawaii. Vol. 9

    SciTech Connect (OSTI)

    Not Available

    1983-06-01

    This report presents the data accumulated during January 1983 at the intermediate photovoltaic project at G.N. Wilcox Memorial Hospital, Kauai, Hawaii. Generated energy and environmental (weather) data are presented graphically. Explanations of irregularities not attributable to weather are provided.

  9. Intermediate photovoltaic system application experiment operational performance report. Volume 1. For G. N. Wilcox Memorial Hospital, Kauai, Hawaii

    SciTech Connect (OSTI)

    Not Available

    1982-09-01

    Presented are the data accumulated during January, February, and March 1982 at the intermediate photovoltaic project at G.N. Wilcox Memorial Hospital, Kauai, Hawaii. Generated energy and environmental (weather) data are presented graphically. Explanations of irregularities not attributable to weather are provided.

  10. Intermediate photovoltaic system application experiment operational performance report. Volume 2 for G. N. Wilcox Memorial Hospital, Kauai, HI

    SciTech Connect (OSTI)

    Not Available

    1982-10-01

    Presented are the data accumulated during April and May 1982 at this intermediate photovoltaic project at G.N. Wilcox Memorial Hospital, Kauai, Hawaii. Generated energy and environmental (weather) data are presented graphically. Explanations of irregularities not attributable to weather are provided.

  11. Evaluation of AFBC co-firing of coal and hospital wastes. Technical report, January 1989--August 1990

    SciTech Connect (OSTI)

    Not Available

    1991-02-01

    The purpose of this program is to expand the use of coal by utilizing CFB (circulating fluidized bed) technology to provide an environmentally safe method for disposing of waste materials. Hospitals are currently experiencing a waste management crisis. In many instances, they are no longer permitted to burn pathological and infectious wastes in incinerators. Older hospital incinerators are not capable of maintaining the stable temperatures and residence times necessary in order to completely destroy toxic substances before release into the atmosphere. In addition, the number of available landfills which can safely handle these substances is decreasing each year. The purpose of this project is to conduct necessary research investigating whether the combustion of the hospital wastes in a coal-fired circulating fluidized bed boiler will effectively destroy dioxins and other hazardous substances before release into the atmosphere. If this is proven feasible, in light of the quantity of hospital wastes generated each year, it would create a new market for coal -- possibly 50 million tons/year.

  12. Laterality of Motor Symptom Onset, Disease Progression, and Cognition in Parkinson's Disease

    E-Print Network [OSTI]

    Chau, Phuong My

    2010-08-31

    The current study examined whether laterality of initial motor symptom onset (left-sided onset vs. right-sided onset) in Parkinson's disease (PD) would predict the pattern and/or severity of cognitive deficits measured at ...

  13. Development of a chronic sublethal sediment bioassay using the estuarine amphipod Leptocheirus plumulosus (Shoemaker)

    SciTech Connect (OSTI)

    Emery, V.L. Jr.; Moore, D.W.; Gibson, A.B. [Army Corps of Engineers, Vicksburg, MS (United States). Waterways Experiment Station; Gray, B.R.; Duke, B.M.; Wright, R.B.; Farrar, J.D. [AScI Corp., Vicksburg, MS (United States)

    1997-09-01

    Based on the need for a test to evaluate chronic sublethal toxicity in estuarine sediments, a 28-d sediment bioassay with the estuarine amphipod, Leptocheirus plumulosus (Shoemaker) was developed. The test was initiated with animals less than 2 weeks old. Test endpoints included survival, growth, and reproduction. Factors with the potential to influence test animal performance such as artificial sea salts, salinity, food ration, size at test initiation, intraspecific density, sediment grain size, and diet were evaluated. For example, intraspecific densities between 10 and 60 animals/beaker did not affect survival, growth, or reproduction. Similarly, L. plumulosus were tolerant of a wide range of sediment grain sizes with only extremely fine grained or coarse grained material significantly affecting survival, growth, and reproduction. Test performance criteria included control survival (> 80%) and reproduction and response to a reference toxicant test with cadmium chloride in a control chart format.

  14. Branchial and renal pathology in the fish exposed chronically to methoxy ethyl mercuric chloride

    SciTech Connect (OSTI)

    Gill, T.S.; Pant, J.C.; Tewari, H.

    1988-08-01

    Pathological manifestations causally related to pesticide poisoning have been described in both surficial and internal tissues of the fishes. Among the various organomercurials are phenyl mercuric acetate, methyl mercuric dicyanidiamide, methoxy ethyl mercuric chloride, methoxy ethyl mercuric silicate etc. Of these, the methoxy ethyl mercuric chloride (MEMC) is used in agriculture as an antifungal seed dressing, and its toxicity is primarily manifest in the Hg/sup 2 +/ ion. This report describes pathogenesis of branchial and renal lesions in the common freshwater fish, Puntius conchonius exposed chronically to sublethal levels of MEMC. Prior to this, alterations in the peripheral blood and metabolite levels in response to experimental MEMC poisoning have been demonstrated in this species.

  15. ANTI-INFLAMMATORY PROPERTY OF THE CANNABINOID AGONIST WIN-55212-2 IN A RODENT MODEL OF CHRONIC BRAIN

    E-Print Network [OSTI]

    Wenk, Gary

    ANTI-INFLAMMATORY PROPERTY OF THE CANNABINOID AGONIST WIN-55212-2 IN A RODENT MODEL OF CHRONIC-methanone mesylate (WIN-55212- 2), on microglial activation and spatial memory performance, using a well/h for 3 weeks) into the fourth ventricle of young rats. WIN-55212-2 (0.5 or 1.0 mg/kg/day, i

  16. Disease resistance and performance of blended populations of creepi 

    E-Print Network [OSTI]

    Abernathy, Scott David

    1999-01-01

    Plant diseases are a major problem on creeping bentgrass greens and can significantly decrease putting quality. Blended populations comprised of two or more cultivars within the same species have been utilized to decrease disease development...

  17. Goal-directed Behaviour & Apathy in Parkinson's Disease 

    E-Print Network [OSTI]

    Cox, Simon

    2009-11-26

    Apathy has been described as a highly-prevalent symptom of Parkinson's disease that has a significant effect upon quality of life, even when the motor symptoms of the disease are taken into account.

  18. Characterization of a Drosophila model of Huntington's disease

    E-Print Network [OSTI]

    Lee, Wyan-Ching Mimi

    2006-01-01

    Huntington's disease (HD) is an autosomal dominant neurological disorder caused by a polyglutamine (polyQ) repeat expansion in the huntingtin (Htt) protein. The disease is characterized by neurodegeneration and formation ...

  19. Mycosphaerella species causing leaf disease in South African Eucalyptus plantations

    E-Print Network [OSTI]

    Mycosphaerella species causing leaf disease in South African Eucalyptus plantations Gavin C. HUNTER Eucalyptus plantations provide an important source of hardwood for forestry industries, worldwide. Several species of Mycosphaerella are associated with a destructive Eucalyptus leaf disease known

  20. Women and Heart Disease: Neglected Directions for Future Research

    E-Print Network [OSTI]

    Barrett-Connor, Elizabeth

    2009-01-01

    009-9110-0 Women and Heart Disease: Neglected Directions forage 65, women have less heart disease than men. For many1980s showed a lower risk of heart attacks in postmenopausal

  1. Endemic models for the spread of infectious diseases with arbitrarily ...

    E-Print Network [OSTI]

    SIAM (#1) 1035 1999 Jan 20 12:53:14

    2000-10-03

    have general length distributions and disease survival functions, the different time ..... In order to describe the duration of the various stages and the related disease ...... Approaches to Problems in Resource Management and Epidemiology, ...

  2. Role of the hedgehog signalling pathway in inflammatory bowel disease 

    E-Print Network [OSTI]

    Lees, Charles William

    2009-01-01

    Introduction. The inflammatory bowel diseases (IBD), Crohn’s disease (CD) and ulcerative colitis (UC), are common in Western Europe (200-400 cases /100,000) and associated with substantial morbidity, although mortality ...

  3. Neurodegenerative diseases: Lessons from genome-wide screens in small model organisms Molecular mechanisms of aging-related neurodegenerative diseases: emerging views

    E-Print Network [OSTI]

    Breitling, Rainer

    , including Parkinson's disease, polyglutamine expansion diseases and Alzheimer's disease, are associated used to model these diseases and high throughput genetic screens using these models have led-analysis #12;3 Introduction Several age-related neurodegenerative diseases, including Parkinson's disease

  4. (See reverse side) Information about Meningococcal Disease and Vaccination

    E-Print Network [OSTI]

    Dennett, Daniel

    is infected and is coughing or sneezing. Who is at most risk for getting meningococcal disease? High

  5. MYELOID NEOPLASIA The derivation of diagnostic markers of chronic myeloid leukemia progression

    E-Print Network [OSTI]

    Raftery, Adrian

    therapeutic outcomes are so closely tied to disease phase, these probabilities can be used to determine a risk at the time of CP diagnosis, making it difficult to adapt therapy to the risk level of each patient,16 A short list is critical as target validation is time, cost, and labor intensive; and a small set

  6. Exploring Disease Transmission On Networks with Winfried Just

    E-Print Network [OSTI]

    Just, Winfried

    the relevant contact network, depends on the particular disease. Think of the flu vs. a computer virus vs of disease transmission Infectious diseases are caused by pathogens (such as viruses, bacteria, fungi identical. Such models can be embodied in computer code as agent-based models. Winfried Just and Ying Xin

  7. Disease transmission by cannibalism: rare event or common occurrence?

    E-Print Network [OSTI]

    Antonovics, Janis

    Disease transmission by cannibalism: rare event or common occurrence? Volker H. W. Rudolf Cannibalism has been documented as a possible disease transmission route in several species, including humans. However, the dynamics resulting from this type of disease transmission are not well understood. Using

  8. Neurobiology of Disease Parkin Directly Modulates 26S Proteasome Activity

    E-Print Network [OSTI]

    Lübbert, Hermann

    . Introduction Parkinson's disease (PD) is a major neurodegenerative disease characterized by the degenerationNeurobiology of Disease Parkin Directly Modulates 26S Proteasome Activity Ji Won Um,1 Eunju Im,1-University Bochum, D-44780 Bochum, Germany, and 4Biofrontera Bioscience GmbH, D-51377 Leverkusen, Germany Parkinson

  9. Neuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response

    E-Print Network [OSTI]

    Sulzer, David

    in a wide range of toxin-based, inflammatory and genetic Parkinson's disease animal models. KeywordsNeuroinflammation in Parkinson's Disease Animal Models: A Cell Stress Response or a Step neuroin- flammatory processes are exacerbated in Parkinson's disease, including glial- mediated reactions

  10. Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases

    E-Print Network [OSTI]

    Bellugi, Ursula

    such as Parkinson's disease and amyotrophic lateral sclerosis where patients' cells have been successfully repro the end-stage of the disease. Mouse models provide a means to mimic human genetic forms of diseases. Owingto tech- nical challenges, species differences and genetic background, even neurologic

  11. Emerging infectious diseases of plants: pathogen pollution, climate change

    E-Print Network [OSTI]

    Schweik, Charles M.

    Emerging infectious diseases of plants: pathogen pollution, climate change and agrotechnology, Boston, MA 02115, USA Emerging infectious diseases (EIDs) pose threats to conservation and public health a series of emerging plant diseases. We include EIDs of cultivated and wild plants, some of which

  12. Understanding Equine Strangles: Signs of Disease, Management and Prevention1

    E-Print Network [OSTI]

    Watson, Craig A.

    in 1251. The infection is highly contagious in horse populations and can recur on farms with previous outbreaks of the disease. It is one of the most commonly diagnosed contagious diseases of the horse signs of infection. Complications of Disease Fortunately, although strangles is highly contagious

  13. A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN

    E-Print Network [OSTI]

    A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN BY R. R. RUCKER, W. J. WHIPPLE, J. R A CONTAGIOUS DISEASE OF SALMON POSSIBLY OF VIRUS ORIGIN By R. R. Rucker, W. J. Whipple, J. R. Parvin and C. A #12;A CONTAGIOUS DISEASE OF SALMON, POSSIBLY OF VIRUS ORIGIN By R. R. Rucker,! Fishery Research

  14. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  15. An investigation of the genetic determinants of succeptibility and disease behavoir in early onset Inflammatory Bowel Disease in Scottish children. 

    E-Print Network [OSTI]

    Russell, Richard K

    2008-01-01

    A series of investigations examining the importance of genetic factors in the development of the inflammatory bowel diseases (IBD) namely Crohn’s disease (CD), Ulcerative Colitis (UC) and Indeterminate Colitis (IC) has ...

  16. Neurobiology of Disease Neuroinflammation Alters the Hippocampal Pattern of

    E-Print Network [OSTI]

    Wenk, Gary

    chronically infused with lipopolysaccharide (LPS) (0.25 g/h) into the fourth ventricle for 28 d. On day 29 and CA3 regions of LPS-infused rats, Arc and OX-6 (specific for major histocompatibility complex class II immunoreactivity) and elevated exploration-induced Arc expression compared with control-infused rats. In contrast

  17. Smoking and Ischemic Heart Disease Disparities Between Studies, Genders, Times, and Socioeconomic Strata

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    2009-01-01

    predictors of coronary heart disease among women. Americanon the risk for coronary heart disease even stronger thanx Smoking and Ischemic Heart Disease Disparities Between

  18. Understanding diseases at a molecular level

    SciTech Connect (OSTI)

    Rosev, Tatjana K [Los Alamos National Laboratory

    2008-01-01

    A group of scientists at Los Alamos National Laboratory in 2008 successfully pioneered a microscope able to track protein-sized, hard to see particles in three dimensions. The 3D Tracking Microscope, designed and developed by James H. Werner, Guillaume A. Lessard, Nathan Wells and Peter M. Goodwin of LANL's Center for Integrated Nanotechnologies, won a 2008 R&D 100 award. The team's invention is a unique confocal 3D tracking microscope capable of following the motion of nanometer-sized objects, such as individual molecules, quantum dots, organic fluorophores and single green fluorescent proteins as they zoom through three-dimensional space at rates faster than many intracellular transport processes. The 3D tracking microscope can follow the transport of nanometer-sized particles at micrometer per second rates. This enables researchers to follow individual protein, ribonucleic acid (RNA), or deoxyribonucleic acid (DNA) motion throughout the full three-dimensional volume of a cell to discover the path a particular biomolecule takes, the method it employs to get there and the specific proteins it may be interacting with along the way. In addition to applications in molecular spectroscopy and materials research, the 3D tracking microscope is a powerful tool primarily in the fields of cellular biology and biomedical research, Werner said. 'The 3D tracking microscope will advance our understanding of the molecular basis and kinetics of many diseases, such as cancer, diabetes, or muscular dystrophy,' he said. 'We anticipate the microscope will become a valuable weapon in the arsenal of biomedical researchers who are fighting to find cures for cancer, heart disease and other protein or DNA-based diseases.'

  19. Distinct pathological phenotypes of Creutzfeldt-Jakob disease in recipients of prion-contaminated growth hormone

    E-Print Network [OSTI]

    2015-01-01

    three months of chronic dry cough, two months of right toewith dysautonomia, a dry cough, neuropathy and cerebellarof dysautonomia, dry cough, and sensorimotor neuropathy.

  20. Spatial and temporal variations in indoor environmental conditions, human occupancy, and operational characteristics in a new hospital building

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ramos, Tiffanie; Dedesko, Sandra; Siegel, Jeffrey A.; Gilbert, Jack A.; Stephens, Brent

    2015-03-02

    The dynamics of indoor environmental conditions, human occupancy, and operational characteristics of buildings influence human comfort and indoor environmental quality, including the survival and progression of microbial communities. A suite of continuous, long-term environmental and operational parameters were measured in ten patient rooms and two nurse stations in a new hospital building in Chicago, IL to characterize the indoor environment in which microbial samples were taken for the Hospital Microbiome Project. Measurements included environmental conditions (indoor dry-bulb temperature, relative humidity, humidity ratio, and illuminance) in the patient rooms and nurse stations; differential pressure between the patient rooms and hallways; surrogatemore »measures for human occupancy and activity in the patient rooms using both indoor air CO? concentrations and infrared doorway beam-break counters; and outdoor air fractions in the heating, ventilating, and air-conditioning systems serving the sampled spaces. Measurements were made at 5-minute intervals over consecutive days for nearly one year, providing a total of ~8×10? data points. Indoor temperature, illuminance, and human occupancy/activity were all weakly correlated between rooms, while relative humidity, humidity ratio, and outdoor air fractions showed strong temporal (seasonal) patterns and strong spatial correlations between rooms. Differential pressure measurements confirmed that all patient rooms were operated at neutral pressure. The patient rooms averaged about 100 combined entrances and exits per day, which suggests they were relatively lightly occupied compared to higher traffic environments (e.g., retail buildings) and more similar to lower traffic office environments. There were also clear differences in several environmental parameters before and after the hospital was occupied with patients and staff. Characterizing and understanding factors that influence these building dynamics is vital for hospital environments, where they can impact patient health and the survival and spread of healthcare associated infections.« less

  1. Spatial and temporal variations in indoor environmental conditions, human occupancy, and operational characteristics in a new hospital building

    SciTech Connect (OSTI)

    Ramos, Tiffanie; Dedesko, Sandra; Siegel, Jeffrey A.; Gilbert, Jack A.; Stephens, Brent

    2015-03-02

    The dynamics of indoor environmental conditions, human occupancy, and operational characteristics of buildings influence human comfort and indoor environmental quality, including the survival and progression of microbial communities. A suite of continuous, long-term environmental and operational parameters were measured in ten patient rooms and two nurse stations in a new hospital building in Chicago, IL to characterize the indoor environment in which microbial samples were taken for the Hospital Microbiome Project. Measurements included environmental conditions (indoor dry-bulb temperature, relative humidity, humidity ratio, and illuminance) in the patient rooms and nurse stations; differential pressure between the patient rooms and hallways; surrogate measures for human occupancy and activity in the patient rooms using both indoor air CO? concentrations and infrared doorway beam-break counters; and outdoor air fractions in the heating, ventilating, and air-conditioning systems serving the sampled spaces. Measurements were made at 5-minute intervals over consecutive days for nearly one year, providing a total of ~8×10? data points. Indoor temperature, illuminance, and human occupancy/activity were all weakly correlated between rooms, while relative humidity, humidity ratio, and outdoor air fractions showed strong temporal (seasonal) patterns and strong spatial correlations between rooms. Differential pressure measurements confirmed that all patient rooms were operated at neutral pressure. The patient rooms averaged about 100 combined entrances and exits per day, which suggests they were relatively lightly occupied compared to higher traffic environments (e.g., retail buildings) and more similar to lower traffic office environments. There were also clear differences in several environmental parameters before and after the hospital was occupied with patients and staff. Characterizing and understanding factors that influence these building dynamics is vital for hospital environments, where they can impact patient health and the survival and spread of healthcare associated infections.

  2. Intermediate photovoltaic system application experiment operational performance report. Volume 5. For G. N. Wilcox Memorial Hospital, Kauai, Hawaii for September 1982

    SciTech Connect (OSTI)

    Not Available

    1983-01-01

    Presented are the data accumulated during September 1982 at the intermediate photovoltaic project at G.N. Wilcox Memorial Hospital, Kauai, Hawaii. Generated energy and environmental (weather) data are presented graphically. Explanations of irregularities not attributable to weather are provided.

  3. Intermediate photovoltaic system application experiment operational performance report for G. N. Wilcox Memorial Hospital, Kauai, Hawaii for October 1982. Volume VI

    SciTech Connect (OSTI)

    Not Available

    1983-01-01

    Presented are the data accumulated during October 1982 at the intermediate project at G.N. Wilcox Memorial Hospital, Kauai, Hawaii. Generated energy and environmental (weather) data are presented graphically. Explanations of irregularities not attributable to weather are provided.

  4. Intermediate photovoltaic system application experiment operational performance report. Volume 8. For G. N. Wilcox Memorial Hospital, Kauai, Hawaii for December 1982

    SciTech Connect (OSTI)

    Not Available

    1983-03-01

    Presented are the data accumulated during December 1982 at the intermediate photovoltaic project at G. N. Wilcox Memorial Hospital, Kauai, Hawaii. Generated energy and environmental (weather) data are presented graphiclaly. Explanations of irregularities not attributable to weather are provided.

  5. Beyond Occupational Differences: The Importance of Cross-cutting Demographics and Dyadic Toolkits for Collaboration in a U.S. Hospital

    E-Print Network [OSTI]

    DiBenigno, Julia Marie

    We use data from a 12-month ethnographic study of two medical-surgical units in a U.S. hospital to examine how members from different occupations can collaborate with one another in their daily work despite differences in ...

  6. Chronic toxicity of 2,4,6-trinitrotoluene to a marine polychaete and an estuarine amphipod

    SciTech Connect (OSTI)

    Green, A.; Moore, D.; Farrar, D.

    1999-08-01

    The chronic toxicity of sediment-associated 2,4,6-trinitrotoluene (TNT) to the marine polychaete Neanthes arenaceodentata and the estuarine amphipod Leptocheirus plumulosus was evaluated. Test organisms were exposed to sediments spiked with radiolabeled TNT for 28 d, after which time the endpoints of mortality, growth, and reproduction (L. plumulosus only) were assayed and compared against the TNT tissue concentrations as well as the TNT sediment concentrations. Survival was significantly reduced at a tissue concentration of 61 {micro}g TNT/g wet wt tissue in N. arenaceodentata and L. plumulosus with enhancement (significant for N. arenaceodentata) occurring at the lower TNT concentrations. Growth was significantly reduced at the highest TNT exposure of 10.0 {micro}g TNT/g wet wt tissue in L. plumulosus. Reproduction was significantly reduced at a tissue concentration of 6.3 {micro}g TNT/g wet wt tissue in L. plumulosus. The results of this study demonstrate that both N. arenaceodentata and L. plumulosus are sensitive to the presence of sediment-associated TNT and that more information is needed about the toxicity of TNT to benthic fauna to facilitate risk assessment and management of TNT-contaminated sites.

  7. Spred2 is involved in imatinib-induced cytotoxicity in chronic myeloid leukemia cells

    SciTech Connect (OSTI)

    Liu, Xiao-Yun; Yang, Yue-Feng; Wu, Chu-Tse; Xiao, Feng-Jun; Zhang, Qun-Wei [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Ma, Xiao-Ni [Lanzhou University of Technology, Lanzhou 730050 (China)] [Lanzhou University of Technology, Lanzhou 730050 (China); Li, Qing-Fang; Yan, Jun [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Wang, Hua, E-mail: wanghualjh@gmail.com [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China); Wang, Li-Sheng, E-mail: wangls@nic.bmi.ac.cn [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)] [Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing 100850 (China)

    2010-03-19

    Spreds, a recently established class of negative regulators of the Ras-ERK (extracellular signal-regulated kinase) pathway, are involved in hematogenesises, allergic disorders and tumourigenesis. However, their role in hematologic neoplasms is largely unknown. Possible effects of Spreds on other signal pathways closely related to Ras-ERK have been poorly investigated. In this study, we investigated the in vitro effects of Spred2 on chronic myeloid leukemia (CML) cells. In addition to inhibiting the well-established Ras-ERK cascade, adenovirus-mediated Spred2 over-expression inhibits constitutive and stem cell factor (SCF)-stimulated sphingosine kinase-1 (SPHK1) and Mcl-1 expression, as well as inhibiting proliferation and inducing apoptosis in CML cells. In K562 cells and primary CML cells, imatinib induces endogenous Spred2 expression. Spred2 silencing by stable RNA interference partly protects K562 cells against imatinib-induced apoptosis. Together, these data implicate Spred2 in imatinib-induced cytotoxicity in CML cells, possibly by inhibiting the Ras-ERK cascade and the pro-survival signaling molecules SPHK1 and Mcl-1. These findings reveal potential targets for selective therapy of CML.

  8. Chronic exposure to bisphenol A reduces SULT1A1 activity in the human placental cell line BeWo

    E-Print Network [OSTI]

    Mitra, Pallabi

    2006-10-27

    Chronic exposure to bisphenol A reduces SULT1A1 activity in the human placental cell line BeWo Pallabi Mitra Department of Pharmaceutical Chemistry University of Kansas October 27, 2006 Outline ? Placental structure and models ? Placental... permeation ? Placental metabolism and regulation (induction/inhibition) ? Sulfotransferase enzymes in trophoblast ? Bisphenol A ? Effects of bisphenol A on SULT1A1 ? Conclusions The placental barrier Mother?s blood ?Trophoblasts and syncytiotrophoblasts line...

  9. The tolerance of lambs to chronic and acute administration of insulin as a measure of ruminal development 

    E-Print Network [OSTI]

    Reagor, John Charles

    1963-01-01

    Characteristics and Relative Ranking of the Tolerance to Insulin . . . . . . . . . . . . . 21 6. Experiment III: Coefficients of Correlation Among Blood Glucose Values Befoze and After In]ection of Insulin and Characteristics of Ruminal Development of Lambs... with Previous Chronic Insulin . . . . . ~ 26 Experiment III; Coefficients of Correlation Among Blood Glucose Values Before and After In)ection of Insulin and Characteristics of Ruminal Development of Lambs With no Previous Insulin Treatment Experiment III...

  10. Percutaneous Retrograde Recanalization of the Celiac Artery by Way of the Superior Mesenteric Artery for Chronic Mesenteric Ischemia

    SciTech Connect (OSTI)

    Joseph, George Chacko, Sujith Thomas

    2013-02-15

    A 52-year-old man presented with recurrent postprandial abdominal pain, sitophobia, and progressive weight loss. Chronic mesenteric ischemia (CMI) due to subtotal occlusion of the superior mesenteric artery (SMA) and flush occlusion of the celiac artery (CA) was diagnosed. Retrograde recanalization of the CA by way of a collateral channel from the SMA was performed using contemporary recanalization equipment. The CA and SMA were then stented, resulting in sustained resolution of CMI-related symptoms.

  11. Future personal attributes and job competencies needed by the Texas Department of State Health Services (DSHS), state hospital section, registered nurse managers: a Delphi study 

    E-Print Network [OSTI]

    Harrison, Joseph, Jr.

    2005-11-01

    -1 FUTURE PERSONAL ATTRIBUTES AND JOB COMPETENCIES NEEDED BY THE TEXAS DEPARTMENT OF STATE HEALTH SERVICES (DSHS), STATE HOSPITAL SECTION, REGISTERED NURSE MANAGERS: A DELPHI STUDY A Dissertation by JOSEPH HARRISON, JR. Submitted to the Office of Graduate... ? 2005 JOSEPH HARRISON, JR. ALL RIGHTS RESERVED FUTURE PERSONAL ATTRIBUTES AND JOB COMPETENCIES NEEDED BY THE TEXAS DEPARTMENT OF STATE HEALTH SERVICES (DSHS), STATE HOSPITAL SECTION, REGISTERED NURSE MANAGERS: A DELPHI STUDY A Dissertation...

  12. Upregulation of Cannabinoid Type 1 Receptors in Dopamine D2 Receptor Knockout Mice Is Reversed by Chronic Forced Ethanol Consumption

    SciTech Connect (OSTI)

    Thanos, P.K.; Wang, G.; Thanos, P.K.; Gopez, V.; Delis, F.; Michaelides, M.; Grand, D.K.; Wang, G.-J.; Kunos, G.; Volkow, N.D.

    2011-01-01

    The anatomical proximity of the cannabinoid type 1 (CNR1/CB1R) and the dopamine D2 receptors (DRD2), their ability to form CB1R-DRD2 heteromers, their opposing roles in locomotion, and their involvement in ethanol's reinforcing and addictive properties prompted us to study the levels and distribution of CB1R after chronic ethanol intake, in the presence and absence of DRD2. We monitored the drinking patterns and locomotor activity of Drd2+/+ and Drd2-/- mice consuming either water or a 20% (v/v) ethanol solution (forced ethanol intake) for 6 months and used the selective CB1 receptor antagonist [{sup 3}H]SR141716A to quantify CB1R levels in different brain regions with in vitro receptor autoradiography. We found that the lack of DRD2 leads to a marked upregulation (approximately 2-fold increase) of CB1R in the cerebral cortex, the caudate-putamen, and the nucleus accumbens, which was reversed by chronic ethanol intake. The results suggest that DRD2-mediated dopaminergic neurotransmission and chronic ethanol intake exert an inhibitory effect on cannabinoid receptor expression in cortical and striatal regions implicated in the reinforcing and addictive properties of ethanol.

  13. Human Neural Stem Cells Differentiate and Promote Locomotor Recovery in an Early Chronic Spinal coRd Injury NOD-scid Mouse Model

    E-Print Network [OSTI]

    Salazar, Desiree L.; Uchida, Nobuko; Hamers, Frank T.; Cummings, Brian J.; Anderson, Aileen J.

    2010-01-01

    Chronic Spinal coRd Injury NOD-scid Mouse Model Desire´e L.in C57BL/6, BUB/ BnJ, and NOD-SCID mice after contusionresistant control strain for NOD mice. Diabetes 41: 60.

  14. The flexDrive: an ultra-light implant for optical control and highly parallel chronic recording of neuronal ensembles in freely moving mice

    E-Print Network [OSTI]

    Voigts, Jakob

    Electrophysiological recordings from ensembles of neurons in behaving mice are a central tool in the study of neural circuits. Despite the widespread use of chronic electrophysiology, the precise positioning of recording ...

  15. Examining the effects of remote monitoring systems on activation, self-care, and quality of life in older patients with chronic heart failure

    E-Print Network [OSTI]

    2015-01-01

    the primary component of chronic heart failure management inCochrane review. Eur J Heart Fail. 2011;13(9):1028Y1040.MLHFQ, Minnesota Living With Heart Failure Questionnaire;

  16. Automated diagnostic kiosk for diagnosing diseases

    DOE Patents [OSTI]

    Regan, John Frederick; Birch, James Michael

    2014-02-11

    An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

  17. Optical detection dental disease using polarized light

    DOE Patents [OSTI]

    Everett, Matthew J. (Livermore, CA); Colston, Jr., Billy W. (Livermore, CA); Sathyam, Ujwal S. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Fried, Daniel (San Francisco, CA)

    2003-01-01

    A polarization sensitive optical imaging system is used to detect changes in polarization in dental tissues to aid the diagnosis of dental disease such as caries. The degree of depolarization is measured by illuminating the dental tissue with polarized light and measuring the polarization state of the backscattered light. The polarization state of this reflected light is analyzed using optical polarimetric imaging techniques. A hand-held fiber optic dental probe is used in vivo to direct the incident beam to the dental tissue and collect the reflected light. To provide depth-resolved characterization of the dental tissue, the polarization diagnostics may be incorporated into optical coherence domain reflectometry and optical coherence tomography (OCDR/OCT) systems, which enables identification of subsurface depolarization sites associated with demineralization of enamel or bone.

  18. PERIORAL BIOMECHANICS, KINEMATICS, AND ELECTROPHYSIOLOGY IN PARKINSON'S DISEASE

    E-Print Network [OSTI]

    Chu, Shin Ying

    2010-11-21

    This investigation quantitatively characterized the orofacial biomechanics, labial kinematics, and associated electromyography (EMG) patterns in individuals with Parkinson's disease (PD) as a function of anti-PD medication ...

  19. Structure of the Newcastle disease virus hemagglutinin-neuraminidase...

    Office of Scientific and Technical Information (OSTI)

    of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk Citation Details In-Document Search Title: Structure of the Newcastle...

  20. Proteins' Amazing Origami Powers: Insight for Potential Disease...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Senior Writer, Office of Science What are the key facts? Better knowledge of protein folding could in turn provide more insight into the diseases associated with malformed...

  1. Genomics of emerging infectious disease: A PLoS collection.

    E-Print Network [OSTI]

    Eisen, Jonathan A; MacCallum, Catriona J

    2009-01-01

    Origins and evolutionary genomics of the 2009 swine-originan Infectious Diseases Genomics Project predict and preventRavel J (2009) The role of genomics in the identification,

  2. Psoriasis disease severity affects patient satisfaction with treatment

    E-Print Network [OSTI]

    Korman, Neil J; Zhao, Yang; Lu, Jackie; Tran, Mary Helen

    2015-01-01

    among patients with psoriasis and psoriatic arthritis in thefindings from the National Psoriasis Foundation surveys,J. Mechanism of disease: psoriasis. N Engl J Med. 2009;361(

  3. Recombinant herpes simplex virus useful for treating neoplastic disease

    DOE Patents [OSTI]

    Whitley, Richard J.; Roizman, Bernard

    2010-06-29

    Recombinant herpes simplex viruses comprising DNA encoding cytokines and methods for treating neoplastic diseases using the inventive recombinant viruses are disclosed.

  4. AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS...

    Office of Scientific and Technical Information (OSTI)

    Converting energy to medical progress nuclear medicine NONE 62 RADIOLOGY AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS; NUCLEAR MEDICINE; PATIENTS; RADIATION...

  5. Bacteria Associated With Colitis and Inflammatory Bowel Disease

    E-Print Network [OSTI]

    Ye, Jingxiao

    2009-01-01

    bowel diseases: antibiotics, probiotics, and prebiotics."clinical trial of probiotics (Lactobacillus johnsonii, LA1)Besides antibiotics, probiotics might also be a potential

  6. Uncertainty and sensitivity analysis of chronic exposure results with the MACCS reactor accident consequence model

    SciTech Connect (OSTI)

    Helton, J.C.; Johnson, J.D.; Rollstin, J.A.; Shiver, A.W.; Sprung, J.L.

    1995-01-01

    Uncertainty and sensitivity analysis techniques based on Latin hypercube sampling, partial correlation analysis and stepwise regression analysis are used in an investigation with the MACCS model of the chronic exposure pathways associated with a severe accident at a nuclear power station. The primary purpose of this study is to provide guidance on the variables to be considered in future review work to reduce the uncertainty in the important variables used in the calculation of reactor accident consequences. The effects of 75 imprecisely known input variables on the following reactor accident consequences are studied: crop growing season dose, crop long-term dose, water ingestion dose, milk growing season dose, long-term groundshine dose, long-term inhalation dose, total food pathways dose, total ingestion pathways dose, total long-term pathways dose, total latent cancer fatalities, area-dependent cost, crop disposal cost, milk disposal cost, population-dependent cost, total economic cost, condemnation area, condemnation population, crop disposal area and milk disposal area. When the predicted variables are considered collectively, the following input variables were found to be the dominant contributors to uncertainty: dry deposition velocity, transfer of cesium from animal feed to milk, transfer of cesium from animal feed to meat, ground concentration of Cs-134 at which the disposal of milk products will be initiated, transfer of Sr-90 from soil to legumes, maximum allowable ground concentration of Sr-90 for production of crops, fraction of cesium entering surface water that is consumed in drinking water, groundshine shielding factor, scale factor defining resuspension, dose reduction associated with decontamination, and ground concentration of 1-131 at which disposal of crops will be initiated due to accidents that occur during the growing season.

  7. Using yeast to study neurodegenerative diseases : amyloid formation as a protective mechanism and a new Alzheimer's disease model

    E-Print Network [OSTI]

    Treusch, Sebastian

    2011-01-01

    Numerous neurodegenerative diseases are pathologically characterized by idiosyncratic protein amyloid inclusions. Not surprisingly amyloid fibrils have long been proposed to be the toxic protein species in these neurodegenerative ...

  8. Do changes in traditional coronary heart disease risk factors over time explain the association between socio-economic status and coronary heart disease?

    E-Print Network [OSTI]

    Franks, Peter; Winters, Paul C; Tancredi, Daniel J; Fiscella, Kevin A

    2011-01-01

    case-control study. Heart 2009, Franks P, Tancredi DJ,status in coronary heart disease risk estimation. Ann Famstatus and coronary heart disease risk prediction. JAMA

  9. Fish oil can help reduce deaths from heart disease,

    E-Print Network [OSTI]

    Shen, Jun

    Fish oil can help reduce deaths from heart disease, according to new evidence reports announced- ute to heart disease. The review also found other evidence indicating that fish oil can help lower in knowledge." Continued, page 2... Evidence Reports Confirm Benefits of Fish Oil Elizabeth Yetley, PhD Joins

  10. Harnessing plasticity to understand learning and treat disease

    E-Print Network [OSTI]

    Kilgard, Michael P.

    Harnessing plasticity to understand learning and treat disease Michael P. Kilgard The University, USA A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies sug- gest that cortical map plasticity is typically a transient phase that improves

  11. Epidemiology / pidmiologie Climate change and plant diseases in Ontario

    E-Print Network [OSTI]

    Boland, Greg J.

    Epidemiology / Épidémiologie Climate change and plant diseases in Ontario G.J. Boland, M.S. Melzer in Ontario will significantly affect the occurrence of plant diseases in agriculture and forestry management plans. Adaptations in agriculture and forestry have been occurring in Ontario for over 100 years

  12. Lung Disease in Pediatrics: is it all in the Genes?

    E-Print Network [OSTI]

    Lung Disease in Pediatrics: is it all in the Genes? Jay K. Kolls, M.D.Jay K. Kolls, M.D. Chair with CF do worse than other? #12;· Outcomes are better at CF centers · There is huge variation in lung with the same mutation do worse than others? · Modifier genes ­ lung disease ­ Tgfb1 ­ Irfd1 ­ neutrophil

  13. Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease

    E-Print Network [OSTI]

    Sulzer, David

    State Psychiatric Institute, New York City, NY 10032, USA Parkinson's disease arises from geneticMultiple hit hypotheses for dopamine neuron loss in Parkinson's disease David Sulzer Departments features. Although many genetic mutations have been suggested as causes or risk factors for Parkinson

  14. Ash dieback disease www.forestry.gov.uk/planthealth

    E-Print Network [OSTI]

    Ash dieback disease www.forestry.gov.uk/planthealth Pest Alert Distribution In Britain, most of the outbreaks of ash dieback disease in the natural environment are confined to East Anglia and Kent, although a small number of outlying cases have been confirmed in northeast England and Scotland. Common ash

  15. Economic Consideration of Mitigation of Foreign Animal Disease Introduction *

    E-Print Network [OSTI]

    McCarl, Bruce A.

    Economic Consideration of Mitigation of Foreign Animal Disease Introduction * Levan Elbakidze, Bruce A. McCarl Department of Agricultural Economics National Center for Foreign Animal and Zoonotic Disease Defense (FAZDD), Texas A&M University, College Station TX, USA The economic implications

  16. Motor signs during the course of Alzheimer disease

    E-Print Network [OSTI]

    to 13.1 years (mean 3.6 years) in five centers in Europe and the United States. MOSIs were rated using signs (MOSIs) are common in Alzheimer disease (AD) and may be associated with rates of cognitive decline a standardized portion of the Unified Parkinson's Disease Rating Scale. Overall, 3,030 visits

  17. Research Fund for the Prevention and Treatment of Kidney Disease

    E-Print Network [OSTI]

    Weber, David J.

    and economic costs associated with these diseases. UMMC accommodates one million patient visits a year With a reputation for innovation and technical and surgical excellence, the UMSOM Division of Transplantation is one global cost for treatment of kidney disease in terms of dialysis and transplantation over the next decade

  18. Impact of chronic lead poisoning on the hematological and biochemical profiles of a fish, Barbus conchonius (Ham)

    SciTech Connect (OSTI)

    Tewari, H.; Gill, S.T.; Pant, J.

    1987-05-01

    The contamination of natural waters by lead is mostly caused by a variety of anthropogenic activities related to increased mining operations and industrial uses of this metal. Adverse effects of lead poisoning in the fishes have been reported with references to both hematological and biochemical variables. The aim of present investigation was to study the effects of chronically administered sublethal levels of inorganic lead on the hematological and biochemical profiles of widely distributed freshwater fish, Barbus conchonius. The variables such as erythrocyte numbers, hemoglobin, hematocrit, mean corpuscular volume, blood glucose, glycogen in liver, skeletal muscles, and myocardium, and cholesterol in blood, liver, ovary, and testes were evaluated.

  19. Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK

    E-Print Network [OSTI]

    Sulzer, David

    and 2 Department of Neurology, Center for Parkinson's Disease and Other Movement Disorders, Columbia Disease, polyglutamine disease (CAG repeat), and Parkinson disease (10). Ã To whom correspondence shouldAutophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and m

  20. Analysis of HLA-DP association with beryllium disease susceptibility in pooled exposed populations

    SciTech Connect (OSTI)

    Cesare Saltini, Massimo Amicosante

    2009-12-19

    Berylliosis or Chronic Beryllium Disease is a chronic granulomatous disorder primarily involving the lung associated with the exposition to low doses of Beryllium (Be) in the workplace. Berylliosis risk has been associated with the presence of a glutamate at position 69 of the HLA-DP beta chain (HLA-DPbetaGlu69) that is expressed in about 97% of disease cases and in 27% of the unaffected Be-exposed controls (p<0.0001) (Richeldi et al. Science 1993; 262: 242-244.12). Since this first observation of an immunogenetic association between berylliosis and HLA-DPbetaGlu69 a number of studies have confirmed the role of this marker as the primary gene of susceptibility of berylliosis (Richeldi et al Am J Ind Med. 1997; 32:337-40; Wang et al J. Immunol. 1999; 163: 1647-53; Saltini et al Eur Respir J. 2001 18:677-84; Rossman et al Am J Respir Crit Care Med. 2002 165:788-94). Moreover, a structure/function interaction between HLA-DP molecules carrying Glu69 and beryllium in driving and developing the immune response against beryllium itself has been observed as: (1) Be-specific T-cells clones obtained from berylliosis patients recognize beryllium as antigen only when presented in the context of the HLA-DP{beta}Glu69 molecules but not in the context of HLA-DP allelic variants carrying Lys69 (Lombardi G et al. J Immunol 2001; 166: 3549-3555), and (2) beryllium presents an affinity for the HLA-DP2, carrying the berylliosis marker of susceptibility HLA-DPGlu69, from 40 to 100 times higher that the HLA-DP molecule carrying Lys69 (Amicosante M. et al Hum. Immunol. 2001; 62: 686-93). However, although the immunogenetic studies performed have been addressed a number of different questions about the genetic association between berylliosis and/or beryllium sensitization, exposure levels to beryllium and HLA markers, a number of questions are still open in the field mainly due to the limitation imposed by the low number of subjects carrying berylliosis or beryllium sensitization enrolled in each immunogenetic study. In this context, the populations of the study already performed in this field by the University of Modena and Rome (by Prof. C. Saltini) and the University of Pennsylvania (by Prof. M. Rossman) have been evaluated by using similar HLA molecular typing methodologies and that both populations have now been followed up for a period of 4 to 7 years. The general objective of this study has to generate a larger data base comprising the two population with which analyze gene disease association with greater statistical power and ascertain the effect of lesser common gener variants which may be missed when analyzing associations on small populations. In particular addressing the role suggested in previous study such as: (1) the role of HLA-DP rare alleles and polymorphisms, and (2) the role of the HLA markers in disease progression from sensitization. The two populations from the already published studies (Saltini et al Eur Respir J. 2001 18:677-84; Rossman et al Am J Respir Crit Care Med. 2002 165:788-94) present similar aspects about: ethnicity, type and length of exposure to Be dust, a broadly similar association between beryllium related abnormalities and HLA. The two population have been pooled and evaluated using common criteria of diagnosis (Sensitized subject: at least 2 positive BeLPT tests each with 2 positive wells; CBD-affected subject: identification of well formed non-caseating granulomas on biopsy), follow up and HLA typing technique (complete HLA-DRB, DQB, DPB high resolution typing using amplification with sequence specific primers or sequence based typing). The two populations included 137 subjects with Beryllium hypersensitized (BH) and 155 Be-exposed controls. Inclusion criteria were met by one hundred and six subjects with Be-hypersensitivity of whom 55 were affected by CBD (age 52 {+-} 11 years; 50 caucasians, 2 African-Americans 2 Hispanics and 1 Asian; 46 males and 9 females; mean duration of Be-exposure 15 {+-} 9 years) and 51 showed Be-sensitization without lung granulomas detected by trans-bronchial biopsy (ag

  1. Commercial Pecans: Controlling Rosette, Diseases and Zinc Deficiency 

    E-Print Network [OSTI]

    Lee, Thomas A.; Krausz, Joseph P.

    2006-04-13

    to be healthy and vigor- ous and for nut quality and yield to be satisfactory, producers must establish sound disease-management programs. Producers can pre- vent losses from diseases and insuff_i cient zinc by implementing ef_fective grove management... fall. Although the foliage is mature and no longer susceptible to the scab fun- gus, the shucks surrounding the nuts are immature and vulnerable to late-season infections. Factors inf_l uencing disease development As you develop a spray program...

  2. Exuberant molluscum contagiosum as a manifestation of the immune reconstitution inflammatory syndrome

    E-Print Network [OSTI]

    Pereira, Bárbara; Fernandes, Cândida; Nachiambo, Ermelinda; Catarino, Carmo; Rodrigues, Ana; Cardoso, Jorge

    2007-01-01

    2): 6 1. Hospital de Curry Cabral, Dermatology Department,2. Hospital de Curry Cabral, Infectious Diseases Department,

  3. PrPSc complexity in different forms of Creutzfeldt-Jakob disease identified using biochemical approaches 

    E-Print Network [OSTI]

    Choi, Young Pyo

    2010-01-01

    Transmissible spongiform encephalopathies (TSEs) or prion diseases are a group of fatal neurodegenerative diseases affecting humans and animal species. Prion diseases are characterized by the conversion of the host encoded ...

  4. HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OF ENERGY CONSERVATION IN RESIDENTIAL BUILDINGS

    E-Print Network [OSTI]

    Budnitz, R.J.

    2011-01-01

    Buildings H M N DISEASE FROM RADON EXPOSURES: U A THE IMPACTVent 78-6 HUMAN DISEASE FROM RADON EXPOSURES: THE IMPACT OFof conservation measures on radon levels, and the disease

  5. Speaker for Nov. 1 Lecture to Discuss Deadliest Viral Diseases...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    These studies have led her from the U.S. Centers for Disease Control and Prevention to Lyon, France, where she was instrumental in designing, constructing and making operational a...

  6. Interpreting noncoding genetic variation in complex traits and human disease

    E-Print Network [OSTI]

    Kellis, Manolis

    Association studies provide genome-wide information about the genetic basis of complex disease, but medical research has focused primarily on protein-coding variants, owing to the difficulty of interpreting noncoding ...

  7. Striatal origin of the pathologic beta oscillations in Parkinson's disease

    E-Print Network [OSTI]

    Boyden, Edward Stuart

    Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations ...

  8. Superspreading and the impact of individual variation on disease emergence

    E-Print Network [OSTI]

    Getz, Wayne M.

    1 Superspreading and the impact of individual variation on disease emergence Supplementary.................................................................................................................................. 4 1.1 Factors contributing to variation in infectiousness 2.2.2 Parameter estimation from mean and proportion of zeros .................................... 8

  9. Enhancing synaptogenesis in diseases characterized by deficiencies in brain synapses

    E-Print Network [OSTI]

    Wurtman, Richard Jay

    The loss of hippocampal and cortical synapses, resulting from impaired synaptogenesis, accelerated synaptic degeneration, or both, is one of the earliest neuropathologic findings in Alzheimer’s Disease and is the finding ...

  10. Introduction Multiple sclerosis (MS) is an inflammatory disease of the

    E-Print Network [OSTI]

    Strominger, Jack L.

    Introduction Multiple sclerosis (MS) is an inflammatory disease of the CNS affecting 0 the frequency of relapses by 30% in relapsing-remitting multiple sclerosis (MS) patients. In the present study

  11. Computational and experimental studies of collagen and related diseases

    E-Print Network [OSTI]

    Yang, Chen, M. Eng. Massachusetts Institute of Technology

    2005-01-01

    Collagen is the most abundant proteins in mammals, and collagen degradation is a process that may be associated with many diseases. In this research we use collagen-like peptides that model both cleavage and noncleavage ...

  12. A PROTEOMIC STUDY OF OXIDATIVE STRESS IN ALCOHOLIC LIVER DISEASE 

    E-Print Network [OSTI]

    Newton, Billy W.

    2010-01-16

    Alcoholic steatosis (AS) is the initial pathology associated with early stage alcoholic liver disease and is characterized by the accumulation of fat in the liver. AS is considered clinically benign as it is reversible, ...

  13. Peptide immunotherapy in models of allergic airways disease 

    E-Print Network [OSTI]

    MacKenzie, Karen Joan

    2011-11-25

    Allergen-reactive CD4+ T cells are implicated in the pathogenesis of allergic disease. Peptide immunotherapy (PIT) involves therapeutic administration of short immunodominant peptides from within the protein allergen to ...

  14. Ecologic niche modeling and spatial patterns of disease transmission

    E-Print Network [OSTI]

    Peterson, A. Townsend

    2006-12-01

    Ecologic niche modeling (ENM) is a growing field with many potential applications to questions regarding the geography and ecology of disease transmission. Specifically, ENM has the potential to inform investigations concerned ...

  15. Biological studies and characterization of the High Plains Disease pathogen 

    E-Print Network [OSTI]

    Mirabile, Joanna

    2001-01-01

    High Plains Disease (HPD), which is a recently recognized affliction causing up to 80% yield losses in corn and wheat, has been suspected to be of viral origin, however no clear evidence existed to validate this claim. ...

  16. Parenting styles, peer influences, and adolescent cardiovascular disease risk factors 

    E-Print Network [OSTI]

    Tramm, Amy Bishop

    2000-01-01

    Parenting and friendship styles were examined as indicators for obesity and risk of cardiovascular disease in 54 Texas adolescents. This study investigated the relationship between parental and peer influences on obesity ...

  17. Cognitive change in motor neurone disease : evidence of orbitofrontal dysfunction 

    E-Print Network [OSTI]

    McNeill, Ewan

    2006-01-01

    This study examines the presence of cognitive changes in amyotrophic lateral sclerosis (ALS), a subtype of motor neurone disease. Past research has shown executive dysfunction in patients with ALS and frontotemporal ...

  18. Marek’s disease virus pathogenesis and latency 

    E-Print Network [OSTI]

    Hunter, Gillian

    2012-11-30

    Marek’s Disease virus (MDV) is a highly contagious, widespread and persistent neoplastic ?-herpesvirus causing extensive lymphoblastic tumours in chickens. The virus is shed in feather dust and spread through inhalation. ...

  19. Nature of language impairment in motor neurone disease 

    E-Print Network [OSTI]

    Rewaj, Phillipa Jane

    2014-07-01

    Background: Language impairment associated with Motor Neurone Disease (MND) has been documented since the late 19th century, yet little is understood about the pervasiveness or nature of these deficits. The common clinical ...

  20. GUIDE FOR IDENTIFICATION OF IMPORTANT DISEASES IN STRAWBERRY IN CALIFORNIA

    E-Print Network [OSTI]

    Ullrich, Paul

    GUIDE FOR IDENTIFICATION OF IMPORTANT DISEASES IN STRAWBERRY IN CALIFORNIA Anthracnose Angular Leaf on the underside of the leaf is one of the most recognizable signs of bacterial infection on strawberry leaves

  1. Transforming South–South Technical Support to Fight Noncommunicable Diseases

    E-Print Network [OSTI]

    Shakow, Aaron D.A.

    At the UN High-Level Meeting on non-communicable diseases (NCD) in September 2011, each member state was challenged to create a multisectoral national policy and plan for the prevention and control of non-communicable ...

  2. Polyamine pathway contributes to the pathogenesis of Parkinson disease

    E-Print Network [OSTI]

    Lewandowski, Nicole M.

    The full complement of molecular pathways contributing to the pathogenesis of Parkinson disease (PD) remains unknown. Here we address this issue by taking a broad approach, beginning by using functional MRI to identify ...

  3. Interactive Whole-Heart Segmentation in Congenital Heart Disease

    E-Print Network [OSTI]

    Pace, Danielle Frances

    We present an interactive algorithm to segment the heart chambers and epicardial surfaces, including the great vessel walls, in pediatric cardiac MRI of congenital heart disease. Accurate whole-heart ...

  4. Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease

    E-Print Network [OSTI]

    Multivariate and univariate neuroimaging biomarkers of Alzheimer's disease Christian Habeck January 2008 Available online 14 February 2008 We performed univariate and multivariate discriminant univariate and multivariate analyses produced markers with high classification accuracy in the derivation

  5. Food, Poverty and Epidemic Disease, Edinburgh: 1840-1850 

    E-Print Network [OSTI]

    MacGillivray, Neil

    2004-01-01

    The thesis first examines the link between nutrition and disease, focusing on the poor of Edinburgh during the 184Os, a time of economic depression and food shortage. The development of nutritional science and the level ...

  6. Host nutrition and infectious disease: an ecological view

    E-Print Network [OSTI]

    Smith, Val H.; Jones II, Tyrees P.; Smith, Marilyn S.

    2005-06-01

    Nutrition is typically discussed in terms of maintaining a proper diet and avoiding nutrient deficiency diseases. However, nutrition can also be viewed from an ecological standpoint: mammalian hosts and their pathogens ...

  7. Strategic Global Alliances in Vaccine Development and Disease Control

    E-Print Network [OSTI]

    Schnaufer, Achim

    Strategic Global Alliances in Vaccine Development and Disease Control Dr Sadhana Sharma BBSRC · UK veterinary vaccinology network · Global veterinary vaccinology alliance #12;3 COORDINATION public engagement on bioscience What we do: #12;"Global Strategic Alliances for the Coordination

  8. Neuroimaging of Discourse Processing in Aging and Alzheimer's Disease

    E-Print Network [OSTI]

    Wang, Clarice

    2011-12-31

    Detection of very early stages of Alzheimer's Disease (AD) has been an area of difficulty for researchers due to confounds with age. Prose recall has been suggested as a diagnostically sensitive test of episodic memory declines in AD; however...

  9. Timing of testing and treatment for asymptomatic diseases

    SciTech Connect (OSTI)

    K?rk?zlar, Eser; Faissol, Daniel M.; Griffin, Paul M.; Swann, Julie L.

    2010-07-01

    Many papers in the medical literature analyze the cost-effectiveness of screening for diseases by comparing a limited number of a priori testing policies under estimated problem parameters. However, this may be insufficient to determine the best timing of the tests or incorporate changes over time. In this paper, we develop and solve a Markov Decision Process (MDP) model for a simple class of asymptomatic diseases in order to provide the building blocks for analysis of a more general class of diseases. We provide a computationally efficient method for determining a cost-effective dynamic intervention strategy that takes into account (i) the results of the previous test for each individual and (ii) the change in the individual’s behavior based on awareness of the disease. We demonstrate the usefulness of the approach by applying the results to screening decisions for Hepatitis C (HCV) using medical data, and compare our findings to current HCV screening recommendations.

  10. Medicating race : heart disease and durable preoccupations with difference

    E-Print Network [OSTI]

    Pollock, Anne, 1975-

    2007-01-01

    This dissertation is an examination of intersections of race, pharmaceuticals, and heart disease over the course of the 20th century and today. Each of these parts has had a dynamic history, and when they are invoked ...

  11. Mechanisms of disease pathogenesis in Spinal Muscular Atrophy 

    E-Print Network [OSTI]

    Mutsaers, Chantal

    2014-06-28

    Low levels of survival motor neuron (SMN) protein cause the autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA), through mechanisms that are poorly defined. SMN protein is ubiquitously expressed, ...

  12. MAPUniversity Hospital Directions from University Hospital to

    E-Print Network [OSTI]

    Capecchi, Mario R.

    .­Fri. 6:30 a.m.­10 p.m., Sat.­Sun. and holidays 8 a.m.­8 p.m. Starbucks Open 24 hours a day, 7 days a week & Rehabilitation Clinic Cashier Customer Service Emergency Department Gift Shop Starbucks Cafeteria (see map

  13. Field Diseases of the Sweet Potato in Texas. 

    E-Print Network [OSTI]

    Taubenhaus, J. J. (Jacob Joseph)

    1919-01-01

    the diseases of the sweet potato. Instead, the corrosive sub: mate treatment should be resorted to because of its efficiency as a fun$ cide arid because of the stimulating effect which it exerts on the resul ing sprouts. After carefully selecting the seed... sweet potatoes for shape (Fig. 1) and discarding all the "shoe strings" (Fig. 2), they should be disinfected with corrosive sublimate solution. This treatment aims at killing the spores of the various disease producing organisms which adhere...

  14. Engineering disease resistance with pectate lyase-like genes

    DOE Patents [OSTI]

    Vogel, John; Somerville, Shauna

    2005-03-08

    A mutant gene coding for pectate lyase and homologs thereof is provided, which when incorporated in transgenic plants effect an increased level disease resistance in such plants. Also is provided the polypeptide sequence for the pectate lyase of the present invention. Methods of obtaining the mutant gene, producing transgenic plants which include the nucleotide sequence for the mutant gene and producing improved disease resistance in a crop of such transgenic plants are also provided.

  15. Characterization of Resistance to Black Spot Disease of Rosa Spp. 

    E-Print Network [OSTI]

    Dong, Qianni

    2014-12-01

    Young-Ki Jo Joshua Yuan Head of Department, Daniel R. Lineberger December 2014 Choose an item. Choose an item. Major Subject: Horticulture Copyright.... These trials typically last 2-3 years to ensure sufficient disease pressure to properly assess the resistance of the plants (Carlson-Nilsson, 2000; Noack, 2003; Shupert, 2005). Lab based detached leaf 4 assay (DLA) is a tool for observing disease...

  16. Arsenic in Drinking Water and Lung Disease in Chile, California and Nevada

    E-Print Network [OSTI]

    Dauphine, David

    2015-01-01

    water to lung function, cough, breathlessness, crepitations,were asked, “Do you often cough when you don’t have a cold,mornings in winter? ” Chronic cough was assessed with the

  17. The inflammatory response in transgastric surgery: gastric content leak leads to localized inflammatory response and higher adhesive disease

    E-Print Network [OSTI]

    2010-01-01

    response and higher adhesive disease Sonia L. Ramamoorthy Æin?ammatory markers, adhesive disease, and morbidity.cantly higher rate of adhesive disease in the SG compared

  18. Thoracic irradiation in Hodgkin's disease: Disease control and long-term complications

    SciTech Connect (OSTI)

    Tarbell, N.J.; Thompson, L.; Mauch, P. (Harvard Medical School, Boston, MA (USA))

    1990-02-01

    A total of 590 patients with Stage IA-IIIB Hodgkin's disease received mantle irradiation at the Joint Center for Radiation Therapy between April 1969 and December 1984 as part of their initial treatment. Recurrence patterns as well as pulmonary, cardiac and thyroid complications were analyzed. Pulmonary recurrence was more frequently seen in patients with large mediastinal adenopathy (LMA); 11% of patients with LMA recurred in the lung in contrast to 3.1% with small or no mediastinal disease, p = 0.003. Hilar involvement, when corrected for size of mediastinal involvement, was not predictive of lung relapse. Patients with LMA also had a high rate of nodal relapse above the diaphragm (40%) following radiation therapy (RT) alone as compared to similarly treated patients with small or no mediastinal adenopathy (6.5%), p less than 0.0001. This risk of nodal recurrence was greatly reduced (4.7%) for LMA patients receiving combined radiation therapy and chemotherapy (CMT), p less than 0.0001. Sixty-seven patients (11%) with hilar or large mediastinal involvement received prophylactic, low dose, whole lung irradiation. No decrease in the frequency of lung recurrence was seen with the use of whole lung irradiation. Radiation pneumonitis was seen in 3% of patients receiving radiation therapy alone. In contrast, the use of whole lung irradiation was associated with a 15% risk of pneumonitis, p = 0.006. The risk of pneumonitis was also significantly increased with the use of chemotherapy (11%), p = 0.0001. Cardiac complications were uncommon with pericarditis being the most common complication (2.2%). Thyroid dysfunction was seen in 25% of patients and appeared to be age-related. These data suggest that the long-term complications of mantle irradiation are uncommon with the use of modern radiotherapeutic techniques.

  19. ORISE: ORAU-managed beryllium lab marks outstanding year in 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    higher risk of developing Chronic Beryllium Disease, a chronic disease that scars the lungs making it more difficult for oxygen to transfer into the bloodstream. The test...

  20. Microsoft Word - DE-AC06-09RL15009 Section H.doc

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    According to medical experts, Chronic Beryllium Disease usually originates in the lungs. Research has found that people with Chronic Beryllium Disease often suffer from a...