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1

A post-entry role for CD63 in early HIV-1 replication  

SciTech Connect (OSTI)

Macrophages and CD4{sup +} lymphocytes are the major reservoirs for HIV-1 infection. CD63 is a tetraspanin transmembrane protein, which has been shown to play an essential role during HIV-1 replication in macrophages. In this study, we further confirm the requirement of CD63 in early HIV-1 replication events in both macrophages and a CD4{sup +} cell line. Further analysis revealed that viral attachment and cell-cell fusion were unaffected by CD63 silencing. However, CD63-depleted macrophages showed a significant decrease in the initiation and completion of HIV-1 reverse transcription, affecting subsequent events of the HIV-1 life cycle. Integration of HIV-1 cDNA as well as the formation of 2-LTR circles was notably reduced. Reporter assays showed that CD63 down regulation reduced production of the early HIV protein Tat. In agreement, CD63 silencing also inhibited production of the late protein p24. These findings suggest that CD63 plays an early post-entry role prior to or at the reverse transcription step.

Li Guangyu; Dziuba, Natallia; Friedrich, Brian [Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0435 (United States); Murray, James L. [Zirus, Inc., 1384 Buford Business Boulevard, Suite 700, Buford, GA 30518 (United States); Ferguson, Monique R., E-mail: mrfergus@utmb.ed [Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0435 (United States)

2011-04-10T23:59:59.000Z

2

EARLY-AGE CRACKING REVIEW: MECHANISMS, MATERIAL PROPERTIES,  

E-Print Network [OSTI]

://cementbarriers.org/ and Savannah River National Laboratory website: http://srnl.doe.gov #12;Early-Age Cracking Review: Mechanisms Commission (NRC), the National Institute of Standards and Technology (NIST), the Savannah River National of work performed in part under that contract. This report was prepared in support of the Savannah River

Bentz, Dale P.

3

Successful cognitive aging in persons living with HIV infection  

E-Print Network [OSTI]

medical evaluations. Successful cognitive aging (SCA) wasby a battery of well- validated cognitive tests andself-endorsed cognitive com- plaints. Thirty-two percent of

2011-01-01T23:59:59.000Z

4

Very early age detection of ettringite from pozzolan origin  

Science Journals Connector (OSTI)

Abstract The mineralogical composition of special purpose Portland cements must conform to certain requirements. Sulphate-resistant Portland cements, for instance, the tricalcium aluminate (C3A) and tetracalcium aluminoferrite (C4AF) phase’s contents must be very low to minimize the consequences of the hydration of large amounts of sulphates and the wide fluctuations in volume that would entail. At the same time, for economic, technical and environmental reasons, primarily pozzolanic additions, some of which are aluminic in chemical character, are included in Portland cements. When thermally activated clays such as metakaolin (aluminic pozzolan) are added to Portland cements with low (to nil) C3A content, an \\{AFt\\} phase of pozzolan origin may also form. The present study corroborated previous reports of the formation, but at very early ages (48 h), of such an \\{AFt\\} phase of pozzolan origin, mainly, in a Portland cement blend containing minimal C3A content, an aluminic pozzolan in chemical character (metakaolin, M pozzolan) and excess gypsum, 15.05% (=7.0% SO3); and if C3A content in OPC is high, the \\{AFt\\} phase originated is of pozzolan origin as well, and in addition, of such C3A content, generating so greater or lesser Expansive Synergic Effect, ESE, according to the greater or lesser pozzolanic activity amount originated previously by M pozzolan in this case, and for this reason, being the ettringite from M pozzolan its chief direct and indirect cause. On the other hand, it also proved that such excess gypsum acted as a setting regulator in blended cements with metakaolin and a retarder in all the other cements tested, whether they were pure Portland cements or blends containing a crystalline mineral addition, Q, and also some blended cements with metakaolin can be regarded as being “hydraulic expansive cements” according to ASTM C 845-90 Standard.

V. Rahhal; R. Talero

2014-01-01T23:59:59.000Z

5

Impact of Clade, Geography, and Age of the Epidemic on HIV-1 Neutralization by Antibodies  

Science Journals Connector (OSTI)

...glycoproteins: fusogens, antigens, and immunogens. Science 280 :1884-1888. doi: 10.1126/science.280.5371.1884 . 2. Hemelaar, J . 2013...HIV-1 vaccine development and therapy. Science 341 :1199-1204. doi: 10.1126/science...

Peter Hraber; Bette T. Korber; Alan S. Lapedes; Robert T. Bailer; Michael S. Seaman; Hongmei Gao; Kelli M. Greene; Francine McCutchan; Carolyn Williamson; Jerome H. Kim; Sodsai Tovanabutra; Beatrice H. Hahn; Ronald Swanstrom; Michael M. Thomson; Feng Gao; Linda Harris; Elena Giorgi; Nicholas Hengartner; Tanmoy Bhattacharya; John R. Mascola; David C. Montefiori

2014-08-20T23:59:59.000Z

6

Evidence for kill-butchery events of early Upper Paleolithic age at Kostenki, Russia  

E-Print Network [OSTI]

Evidence for kill-butchery events of early Upper Paleolithic age at Kostenki, Russia John F, Universitetskaya nab., 1, 199034 St. Petersburg, Russia c Institute of the History of Material Culture, Russian Academy of Sciences, Dvortsovaya nab., 18, 191186 St. Petersburg, Russia d Kostenki Museum-Preserve, ul

Holliday, Vance T.

7

Feeding the periphery : modeling early Bronze Age economies and the cultural landscape of the Faynan District, Southern Jordan.  

E-Print Network [OSTI]

??The current study investigates the evolution of southern Levantine societies during the early Bronze Age (ca 3600- 2000 BCE). This study contributes to the reinvestigation… (more)

Muniz, Adolfo A.

2007-01-01T23:59:59.000Z

8

An early Miocene age for a high-temperature event in gneisses from Zabargad Island (Red Sea, Egypt): mantle diapirism?  

E-Print Network [OSTI]

An early Miocene age for a high-temperature event in gneisses from Zabargad Island (Red Sea, Egypt outcropping on Zabargad Island (Red Sea, Egypt). This island, though of limited size (& 4 km2 ), has an almost

Demouchy, Sylvie

9

Prediction of early-age cracking of UHPC materials and structures : a thremo-chemo-mechanics approach  

E-Print Network [OSTI]

Ultra-High Performance Concrete [UHPC] has remarkable performance in mechanical properties, ductility, economical benefit, etc., but early-age cracking of UHPC can become an issue during the manufacturing process due to ...

Shim, JongMin, 1975-

2005-01-01T23:59:59.000Z

10

Miliacin in palaeosols from an Early Iron Age in Ukraine reveal in situ cultivation of broomcorn millet  

E-Print Network [OSTI]

Miliacin in palaeosols from an Early Iron Age in Ukraine reveal in situ cultivation of broomcorn, France 6 Institute of Archaeology in Crimea, National Academy of Science, of Ukraine, Yaltinskaya St. 2, Simferopol 95007, Ukraine 7 Department of Archaeology, University of Cambridge, Downing Street, Cambridge CB2

Paris-Sud XI, Université de

11

Maternal support in early childhood predicts larger hippocampal volumes at school age  

E-Print Network [OSTI]

responses, and larger hippocampal volumes in developing animals. In humans, a relation- ship between effect of maternal support on hippocampal volumes was greater in nondepressed children. These findings provide prospective evidence in humans of the positive effect of early supportive parenting on healthy

12

PLANETARY-SCALE STRONTIUM ISOTOPIC HETEROGENEITY AND THE AGE OF VOLATILE DEPLETION OF EARLY SOLAR SYSTEM MATERIALS  

SciTech Connect (OSTI)

Isotopic anomalies in planetary materials reflect both early solar nebular heterogeneity inherited from presolar stellar sources and processes that generated non-mass-dependent isotopic fractionations. The characterization of isotopic variations in heavy elements among early solar system materials yields important insight into the stellar environment and formation of the solar system, and about initial isotopic ratios relevant to long-term chronological applications. One such heavy element, strontium, is a central element in the geosciences due to wide application of the long-lived {sup 87}Rb-{sup 87}Sr radioactive as a chronometer. We show that the stable isotopes of Sr were heterogeneously distributed at both the mineral scale and the planetary scale in the early solar system, and also that the Sr isotopic heterogeneities correlate with mass-independent oxygen isotope variations, with only CI chondrites plotting outside of this correlation. The correlation implies that most solar system material formed by mixing of at least two isotopically distinct components: a CV-chondrite-like component and an O-chondrite-like component, and possibly a distinct CI-chondrite-like component. The heterogeneous distribution of Sr isotopes may indicate that variations in initial {sup 87}Sr/{sup 86}Sr of early solar system materials reflect isotopic heterogeneity instead of having chronological significance, as interpreted previously. For example, given the differences in {sup 84}Sr/{sup 86}Sr between calcium aluminum inclusions and eucrites ({epsilon}{sup 84}Sr > 2), the difference in age between these materials would be {approx}6 Ma shorter than previously interpreted, placing the Sr chronology in agreement with other long- and short-lived isotope systems, such as U-Pb and Mn-Cr.

Moynier, Frederic; Podosek, Frank A. [Department of Earth and Planetary Science and McDonnell Center for Space Sciences, Washington University, St. Louis, MO 63130 (United States); Day, James M. D. [Geosciences Research Division, Scripps Institution of Oceanography, La Jolla, CA 92093-0244 (United States); Okui, Wataru; Yokoyama, Tetsuya [Department of Earth and Planetary Sciences, Tokyo Institute of Technology, Tokyo 152-8551 (Japan); Bouvier, Audrey [Department of Earth Sciences, University of Minnesota, Minneapolis, MN 55455-0231 (United States); Walker, Richard J., E-mail: moynier@levee.wustl.edu, E-mail: fap@levee.wustl.edu, E-mail: jmdday@ucsd.edu, E-mail: rjwalker@umd.edu, E-mail: okui.w.aa@m.titech.ac.jp, E-mail: tetsuya.yoko@geo.titech.ac.jp, E-mail: abouvier@umn.edu [Department of Geology, University of Maryland, College Park, MD 20742 (United States)

2012-10-10T23:59:59.000Z

13

An HIV Vaccine — Challenges and Prospects  

Science Journals Connector (OSTI)

...successful human vaccines, HIV quickly integrates itself into the DNA of the host cell, where, in some cells, it remains latent and essentially invisible to the immune system. Because latency is established very early — within days to weeks after infection — the window of opportunity wherein HIV... An HIV vaccine has thus far been elusive. Drs. Margaret Johnston and Anthony Fauci remain cautiously optimistic that a substantial increase in our understanding of HIV infection and disease will lead to creative ideas about how to design an effective HIV ...

Johnston M.I.; Fauci A.S.

2008-08-28T23:59:59.000Z

14

Impact of Proficiency Testing Program for Laboratories Conducting Early Diagnosis of HIV-1 Infection in Infants in Low- to Middle-Income Countries  

Science Journals Connector (OSTI)

...intra-uterine and intra-partum transmission. AIDS 9 :F7-F11. 13...and mother-to-child transmission of HIV-1 in rural South...elimination of mother-to-child transmission. Pediatr. Infect. Dis...Characterization of a continuous T-cell line susceptible to the cytopathic...

Albert Garcia; Shambavi Subbarao; Guoqing Zhang; Linda Parsons; John Nkengasong; Chin-Yih Ou; Dennis Ellenberger

2013-12-18T23:59:59.000Z

15

The Ages of Early-Type Stars: Str\\"omgren Photometric Methods Calibrated, Validated, Tested, and Applied to Hosts and Prospective Hosts of Directly Imaged Exoplanets  

E-Print Network [OSTI]

Age determination is undertaken for nearby early-type (BAF) stars, which constitute attractive targets for high-contrast debris disk and planet imaging surveys. Our analysis sequence consists of: acquisition of uvby{\\beta} photometry from catalogs, correction for the effects of extinction, interpolation of the photometry onto model atmosphere grids from which atmospheric parameters are determined, and finally, comparison to the theoretical isochrones from pre-main sequence through post-main sequence stellar evolution models, accounting for the effects of stellar rotation. We calibrate and validate our methods at the atmospheric parameter stage by comparing our results to fundamentally determined Teff and log g values. We validate and test our methods at the evolutionary model stage by comparing our results on ages to the accepted ages of several benchmark open clusters (IC 2602, {\\alpha} Persei, Pleiades, Hyades). Finally, we apply our methods to estimate stellar ages for 3493 field stars, including several w...

David, Trevor J

2015-01-01T23:59:59.000Z

16

Secondary state formation during the early iron age on the island of Sri Lanka : the evolution of a periphery  

E-Print Network [OSTI]

socio-political and economic process during early historica major socio- economic and political process that isthe socio-economic and political process in the hinterlands.

Karunaratne, Priyantha Padmalal

2010-01-01T23:59:59.000Z

17

Discovering Regulated Networks During HIV-1 Latency and Reactivation Sourav Bandyopadhyay, Ryan Kelley, and Trey Ideker  

E-Print Network [OSTI]

corresponding to stages of HIV synthesis. In the early stage, fully spliced mRNAs for Rev, Tat and NefDiscovering Regulated Networks During HIV-1 Latency and Reactivation Sourav Bandyopadhyay, Ryan NETWORKS DURING HIV-1 LATENCY AND REACTIVATION SOURAV BANDYOPADHYAY, RYAN KELLEY, TREY IDEKER1,2 1 Program

18

THE SCHMIDT-KENNICUTT LAW OF MATCHED-AGE STAR-FORMING REGIONS; Pa{alpha} OBSERVATIONS OF THE EARLY-PHASE INTERACTING GALAXY TAFFY I  

SciTech Connect (OSTI)

In order to test a recent hypothesis that the dispersion in the Schmidt-Kennicutt law arises from variations in the evolutionary stage of star-forming molecular clouds, we compared molecular gas and recent star formation in an early-phase merger galaxy pair, Taffy I (UGC 12915/UGC 12914, VV 254) which went through a direct collision 20 Myr ago and whose star-forming regions are expected to have similar ages. Narrowband Pa{alpha} image is obtained using the ANIR near-infrared camera on the mini-TAO 1 m telescope. The image enables us to derive accurate star formation rates within the galaxy directly. The total star formation rate, 22.2 M{sub Sun} yr{sup -1}, was found to be much higher than previous estimates. Ages of individual star-forming blobs estimated from equivalent widths indicate that most star-forming regions are {approx}7 Myr old, except for a giant H II region at the bridge which is much younger. Comparison between star formation rates and molecular gas masses for the regions with the same age exhibits a surprisingly tight correlation, a slope of unity, and star formation efficiencies comparable to those of starburst galaxies. These results suggest that Taffy I has just evolved into a starburst system after the collision, and the star-forming sites are at a similar stage in their evolution from natal molecular clouds except for the bridge region. The tight Schmidt-Kennicutt law supports the scenario that dispersion in the star formation law is in large part due to differences in evolutionary stage of star-forming regions.

Komugi, S. [Joint ALMA Observatory, Alonso de Cordova 3107, Vitacura, Santiago 763-0355 (Chile); Tateuchi, K.; Motohara, K.; Kato, N.; Konishi, M.; Koshida, S.; Morokuma, T.; Takahashi, H.; Tanabe, T.; Yoshii, Y. [Institute of Astronomy, University of Tokyo, Osawa 2-21-1, Mitaka, Tokyo 181-0015 (Japan); Takagi, T. [Institute of Space and Astronautical Science, JAXA, 3-31-1 Yoshinodai, Sagamihara, Kanagawa 229-8510 (Japan); Iono, D.; Kaneko, H.; Ueda, J. [Nobeyama Radio Observatory, National Astronomical Observatory, 462-2 Nobeyama, Minamimaki, Minamisaku, Nagano 384-1305 (Japan); Saitoh, T. R., E-mail: skomugi@alma.cl [Interactive Research Center of Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro 152-0033 (Japan)

2012-10-01T23:59:59.000Z

19

Systemic Expression of HIV-1 tat Gene in Transgenic Mice Induces Endothelial Proliferation and Tumors of Different Histotypes  

Science Journals Connector (OSTI)

...Articles Virology Systemic Expression of HIV-1 tat Gene in Transgenic Mice Induces Endothelial...progression to a malignant phenotype. The HIV tat gene, introduced into the germ line...containing BKV early region and the HIV tat gene, directed by its own promoter...

Alfredo Corallini; Giuseppe Altavilla; Laura Pozzi; Francesca Bignozzi; Massimo Negrini; Paola Rimessi; Francesca Gualandi; and Giuseppe Barbanti-Brodano

1993-11-15T23:59:59.000Z

20

Aging: Health at Advanced Ages  

Science Journals Connector (OSTI)

Abstract This article examines how health and mortality at advanced ages evolves from conditions early in life. The authors summarize the findings, examine econometric strategies to identify causal effects, and discuss the implications of the findings for public policies aimed at improving population health.

G.J. van den Berg; M. Lindeboom

2014-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Research deciphers HIV attack plan  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

deciphers HIV attack plan Research deciphers HIV attack plan These findings will help inform vaccine design and interpretation of vaccine trials, and provide new insights...

22

Please cite this article in press as: DiNapoli, V.A. et al., Early disruptions of the bloodbrain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats, Neurobiol Aging (2007),  

E-Print Network [OSTI]

­brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke the effects of age on stroke progression and outcome in order to explore the association between blood

23

Human macrophages support persistent transcription from unintegrated HIV-1 DNA  

SciTech Connect (OSTI)

Retroviruses require integration of their RNA genomes for both stability and productive viral replication. In HIV infection of non-dividing, resting CD4 T cells, where integration is greatly impeded, the reverse transcribed HIV DNA has limited biological activity and a short half-life. In metabolically active and proliferating T cells, unintegrated DNA rapidly diminishes with cell division. HIV also infects the non-dividing but metabolically active macrophage population. In an in vitro examination of HIV infection of macrophages, we find that unintegrated viral DNA not only has an unusual stability, but also maintains biological activity. The unintegrated linear DNA, 1-LTR, and 2-LTR circles are stable for at least 30 days. Additionally, there is persistent viral gene transcription, which is selective and skewed towards viral early genes such as nef and tat with highly diminished rev and vif. One viral early gene product Nef was measurably synthesized. We also find that independent of integration, the HIV infection process in macrophages leads to generation of numerous chemokines.

Kelly, Jeremy [Department of Molecular and Microbiology, George Mason University, Manassas, Virginia 20110 (United States); Beddall, Margaret H. [Section on Molecular Virology, Laboratory of Cellular and Molecular Regulation, NIMH, Bethesda, Maryland 20892 (United States); Yu Dongyang; Iyer, Subashini R. [Department of Molecular and Microbiology, George Mason University, Manassas, Virginia 20110 (United States); Marsh, Jon W. [Section on Molecular Virology, Laboratory of Cellular and Molecular Regulation, NIMH, Bethesda, Maryland 20892 (United States); Wu Yuntao [Department of Molecular and Microbiology, George Mason University, Manassas, Virginia 20110 (United States); Section on Molecular Virology, Laboratory of Cellular and Molecular Regulation, NIMH, Bethesda, Maryland 20892 (United States)], E-mail: ywu8@gmu.edu

2008-03-15T23:59:59.000Z

24

Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus  

SciTech Connect (OSTI)

Almost all homosexual patients with acquired immunodeficiency syndrome are also actively infected with human cytomegalovirus (HCMV). The authors have hypothesized that an interaction between HCMV and human immunodeficiency virus (HIV), the agent that causes acquired immunodeficiency syndrome, may exist at a molecular level and contribute to the manifestations of HIV infection. In this report, they demonstrate that the immediate-early gene region of HCMV, in particular immediate-early region 2, trans-activates the expression of the bacterial gene chloramphenicol acetyltransferase that is fused to the HIV long terminal repeat and carried by plasmid pHIV-CAT. The HCMV immediate-early trans-activator increases the level of mRNA from the plamid pHIV-CAT. The sequences of HIV that are responsive to trans-activation by the HDMV immediate-early region are distinct from HIV sequences that are required for response to the HIV tat. The stimulation of HIV gene expression by HDMV gene functions could enhance the consequences of HIV infection in persons with previous or concurrent HCMV infection.

Davis, M.G.; Kenney, S.C.; Kamine, J.; Pagano, J.S.; Huang, E.S.

1987-12-01T23:59:59.000Z

25

A new challenge? HIV/AIDS as a development issue  

E-Print Network [OSTI]

children have been infected with the HIV virus · 15 million children under age 18 have lost one or both parents to AIDS. More than 12 million are in sub-Saharan Africa · The chances of orphans going to school parents or go and make money · erosion of number of teachers #12;(b) health sector · new drugs are very

Glasgow, University of

26

Gender differences between predictors of HIV status among PWID in Ukraine  

Science Journals Connector (OSTI)

AbstractBackground The HIV epidemic in Ukraine is among the largest in Europe. While traditionally the epidemic has spread through injection risk behavior, sexual transmission is becoming more common. Previous research has found that women in Ukraine have higher rates of HIV and engage in more HIV risk behavior than men. This study extended that work by identifying risk factors that differentially predict men and women's HIV status among people who inject drugs (PWID) in Ukraine. Methods From July 2010 to July 2013, 2480 sexually active PWID with unknown HIV status were recruited from three cities in Ukraine through street outreach. The average age was 31 years old. Results Women, who made up twenty-eight percent of the sample, had higher safe sex self-efficacy (p Ukraine.

K.F. Corsi; S. Dvoryak; C. Garver-Apgar; J.M. Davis; J.T. Brewster; O. Lisovska; R.E. Booth

2014-01-01T23:59:59.000Z

27

The Search for Effective HIV Vaccines  

Science Journals Connector (OSTI)

...to do with an evolving understanding of the routes of infection. Although many people become infected through the bloodstream, 90 percent of HIV infections are contracted through sexual transmission, with the virus crossing the mucosal tissues that line the genital tract, the rectum, and other body... As we continue to struggle to contain the pandemic of our age, scientists are exploring vaccines that do not prevent initial infection but may prevent or limit viral replication and delay disease progression. Dr. Howard Markel writes that when it comes to ...

Markel H.

2005-08-25T23:59:59.000Z

28

An Early Stone Age Culture of America  

Science Journals Connector (OSTI)

... of Natural History, was directed to a bone deposit on the upper sources of the Cimmaron River near Folsom, New Mexico. Investigations in the following year brought to light evidence ...

1935-10-05T23:59:59.000Z

29

Baseline Cellular HIV DNA Load Predicts HIV DNA Decline and Residual HIV Plasma Levels during Effective Antiretroviral Therapy  

Science Journals Connector (OSTI)

...significant predictive power, but published data on its correlation...correlated with HIV DNA load decrease until...cellular HIV DNA load predicts HIV DNA...significant predictive power, but published data on its correlation...correlated with HIV DNA load decrease until...

Saverio Giuseppe Parisi; Samantha Andreis; Carlo Mengoli; Renzo Scaggiante; Roberto Ferretto; Vinicio Manfrin; Mario Cruciani; Mario Giobbia; Caterina Boldrin; Monica Basso; Massimo Andreoni; Giorgio Palů; Loredana Sarmati

2011-11-30T23:59:59.000Z

30

HIV-1 Envelope Glycan Moieties Modulate HIV-1 Transmission  

Science Journals Connector (OSTI)

...1 cloned directly from uncultured human brain tissue: identification of replication-competent...Dangond, MF McLane, M Essex, and JD Brain. 2007. Noninfectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor...

Ruizhong Shen; Milan Raska; Diane Bimczok; Jan Novak; Phillip D. Smith

2014-10-01T23:59:59.000Z

31

HIV-1 Envelope Glycan Moieties Modulate HIV-1 Transmission  

Science Journals Connector (OSTI)

...HIV-1 after heterosexual transmission. Science 303 :2019-2022. doi: 10.1126/science.1093137 . 9. Wei, X , JM Decker, S Wang...immunity in the acquired immune response. Science 272 :50-53. doi: 10.1126/science...

Ruizhong Shen; Milan Raska; Diane Bimczok; Jan Novak; Phillip D. Smith

2014-10-01T23:59:59.000Z

32

Cost-Effectiveness of HIV Treatment as Prevention in Serodiscordant Couples  

Science Journals Connector (OSTI)

..., the economic value may differ, owing to differences in resource utilization, labor costs, and ability to pay (as it relates to different values of the national gross domestic product [GDP]). We projected the cost-effectiveness of early ART, as compared with delayed ART, among serodiscordant couples... In this study, early initiation of antiretroviral therapy (ART) was shown to be more cost-effective than late initiation of ART in preventing disease transmission among HIV-serodiscordant couples in South Africa and India.

Walensky R.P.; Ross E.L.; Kumarasamy N.

2013-10-31T23:59:59.000Z

33

MATHEMATICAL ANALYSIS OF AGE-STRUCTURED HIV-1 ...  

E-Print Network [OSTI]

the within-host viral fitness and the possible development of drug-resistant ... human immunodeficiency virus type 1, antiretroviral therapy, drug resistance,.

SIAM (#1) 1035 2001 Apr 10 12:32:38

2007-08-22T23:59:59.000Z

34

Rapid selection of escape mutants by the first CD8 T cell responses in acute HIV-1 infection  

SciTech Connect (OSTI)

The recent failure of a vaccine that primes T cell responses to control primary HIV-1 infection has raised doubts about the role of CD8+ T cells in early HIV-1 infection. We studied four patients who were identified shortly after HIV-1 infection and before seroconversion. In each patient there was very rapid selection of multiple HIV-1 escape mutants in the transmitted virus by CD8 T cells, including examples of complete fixation of non-synonymous substitutions within 2 weeks. Sequencing by single genome amplification suggested that the high rate of virus replication in acute infection gave a selective advantage to virus molecules that contained simultaneous and gained sequential T cell escape mutations. These observations show that whilst early HIV-1 specific CD8 T cells can act against virus, rapid escape means that these T cell responses are unlikely to benefit the patient and may in part explain why current HIV-1 T cell vaccines may not be protective.

Korber, Bette Tina Marie [Los Alamos National Laboratory

2008-01-01T23:59:59.000Z

35

Relative Ages of Globular Clusters  

E-Print Network [OSTI]

Ages of extragalactic globular clusters can provide valuable insights into the formation and evolution of galaxies. In this contribution the photometric methods of age dating old globular cluster systems are summarised. The spectroscopic approach is reviewed with an emphasis of the right choice of age diagnostics. We present a new method of quantifying the relatively best age-sensitive spectroscopic index given the quality of a data set and a certain theoretical stellar synthesis model. The relatively best diagnostic plot is constructed from the set of Lick indices and used to age date globular clusters in several early-type galaxies which are part of a large spectroscopic survey of extragalactic globular cluster systems. We find that, independently of host galaxy, metal-poor ([Fe/H] 8 Gyr) and coeval. Metal-rich clusters show a wide range of ages from ~15 down to a few Gyr.

Thomas H. Puzia

2002-10-18T23:59:59.000Z

36

Fighting HIV — Lessons from Brazil  

Science Journals Connector (OSTI)

...people by the end of 2005. Yet Brazil's persistent and aggressive efforts to prevent new HIV infections have probably played an equal or greater role in slowing the spread of the virus and containing the country's epidemic. At the beginning of the 1990s, the epidemics in Brazil and South Africa, both ranked... Dr. Susan Okie writes that Brazil's persistent and aggressive efforts to prevent new HIV infections have played a major role in slowing the spread of the virus and containing the country's epidemic.

Okie S.

2006-05-11T23:59:59.000Z

37

HIV classification using coalescent theory  

SciTech Connect (OSTI)

Algorithms for subtype classification and breakpoint detection of HIV-I sequences are based on a classification system of HIV-l. Hence, their quality highly depend on this system. Due to the history of creation of the current HIV-I nomenclature, the current one contains inconsistencies like: The phylogenetic distance between the subtype B and D is remarkably small compared with other pairs of subtypes. In fact, it is more like the distance of a pair of subsubtypes Robertson et al. (2000); Subtypes E and I do not exist any more since they were discovered to be composed of recombinants Robertson et al. (2000); It is currently discussed whether -- instead of CRF02 being a recombinant of subtype A and G -- subtype G should be designated as a circulating recombination form (CRF) nd CRF02 as a subtype Abecasis et al. (2007); There are 8 complete and over 400 partial HIV genomes in the LANL-database which belong neither to a subtype nor to a CRF (denoted by U). Moreover, the current classification system is somehow arbitrary like all complex classification systems that were created manually. To this end, it is desirable to deduce the classification system of HIV systematically by an algorithm. Of course, this problem is not restricted to HIV, but applies to all fast mutating and recombining viruses. Our work addresses the simpler subproblem to score classifications of given input sequences of some virus species (classification denotes a partition of the input sequences in several subtypes and CRFs). To this end, we reconstruct ancestral recombination graphs (ARG) of the input sequences under restrictions determined by the given classification. These restritions are imposed in order to ensure that the reconstructed ARGs do not contradict the classification under consideration. Then, we find the ARG with maximal probability by means of Markov Chain Monte Carlo methods. The probability of the most probable ARG is interpreted as a score for the classification. To our knowledge, this particular problem was not addressed up to now. The software package Lamarc Kuhner et al. (2000) allows for sampling ARGs, but it assumes that recombination events only involve one breakpoint. However, in HIV recombinants usually have more than one breakpoint. Moreover, Lamarc does not perform an explicit breakpoint detection, but tries to find them by chance. Although this approach is suitable for most situations, it will not lead to satisfying results in case of highly recombining viruses with multiple breakpoints.

Zhang, Ming [Los Alamos National Laboratory; Letiner, Thomas K [Los Alamos National Laboratory; Korber, Bette T [Los Alamos National Laboratory

2008-01-01T23:59:59.000Z

38

Dilated Cardiomyopathy in Transgenic Mice Expressing HIV Tat  

Science Journals Connector (OSTI)

Mechanisms responsible for HIV cardiomyopathy are unknown, but may include direct effects of HIV proteins on the heart. Transgenic mice (TG) expressing HIV Tat protein targeted to the myocardium, +/? Tat TG, have...

Qiujuan Fang; Hong Kan; William Lewis; Fangping Chen…

2009-03-01T23:59:59.000Z

39

Plutonium aging  

SciTech Connect (OSTI)

The author describes the plutonium aging program at the Los Alamos National Laboratory. The aging of plutonium components in the US nuclear weapons stockpile has become a concern due to several events: the end of the cold war, the cessation of full scale underground nuclear testing as a result of the Comprehensive Test Ban Treaty (CTBT) and the closure of the Rocky Flats Plant--the site where the plutonium components were manufactured. As a result, service lifetimes for nuclear weapons have been lengthened. Dr. Olivas will present a brief primer on the metallurgy of plutonium, and will then describe the technical approach to ascertaining the long-term changes that may be attributable to self-radiation damage. Facilities and experimental techniques which are in use to study aging will be described. Some preliminary results will also be presented.

Olivas, J.D.

1999-03-01T23:59:59.000Z

40

Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption  

SciTech Connect (OSTI)

Following primary infection with human immunodeficiency virus type-1 (HIV-1), macrophages are thought to play an important role, as they are one of the first target cells the virus encounters and can also sustain a significant production of viruses over extended periods of time. While the interaction between the primary cellular receptor CD4 and the virus-encoded external envelope glycoprotein gp120 initiates the infection process, it has been suggested that various host factors are exploited by HIV-1 to facilitate adsorption onto the cell surface. Macrophages and other cells found at the infection site can secrete a soluble mammalian lectin, galectin-1, which binds to {beta}-galactoside residues through its carbohydrate recognition domain. Being a dimer, galectin-1 can cross-link ligands expressed on different constituents to mediate adhesion between cells or between cells and pathogens. We report here that galectin-1, but not galectin-3, increased HIV-1 infectivity in monocyte-derived macrophages (MDMs). This phenomenon was likely due to an enhancement of virus adsorption kinetics, which facilitates HIV-1 entry. The fusion inhibitors T-20 and TAK779 remained effective at reducing infection even in the presence of galectin-1, indicating that the galectin-1-mediated effect is occurring at a step prior to fusion. Together, our data suggest that galectin-1 can facilitate HIV-1 infection in MDMs by promoting early events of the virus replicative cycle (i.e. adsorption)

Mercier, Simon; St-Pierre, Christian; Pelletier, Isabelle; Ouellet, Michel [Research Center for Infectious Diseases, CHUL Research Center, Quebec (Canada); Faculty of Medicine, Laval University, Quebec (Canada); Tremblay, Michel J. [Research Center for Infectious Diseases, CHUL Research Center, Quebec (Canada); Faculty of Medicine, Laval University, Quebec (Canada)], E-mail: michel.j.tremblay@crchul.ulaval.ca; Sato, Sachiko [Research Center for Infectious Diseases, CHUL Research Center, Quebec (Canada); Faculty of Medicine, Laval University, Quebec (Canada)], E-mail: sachiko.sato@crchul.ulaval.ca

2008-02-05T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

The effects of HIV Tat DNA on regulating the immune response of HIV DNA vaccine in mice  

Science Journals Connector (OSTI)

HIV trans-activator protein (Tat) is the crucial factor to control HIV transcription, and is usually considered as an important immunogen for the design of HIV vaccine. Recent studies reported some special bio-ac...

Ye Liu; Fusheng Li; Zhi Qi; Yanling Hao; Kunxue Hong; Yong Liu…

2013-09-01T23:59:59.000Z

42

Cognitive Neuropsychology of HIV-Associated Neurocognitive Disorders  

E-Print Network [OSTI]

of HIV-associated cognitive impairment. The ClinicalRourke, B. P. (2003). Cognitive complaints, depression,predicts subjective cognitive complaints in HIV infection.

Woods, Steven Paul; Moore, David J.; Weber, Erica; Grant, Igor

2009-01-01T23:59:59.000Z

43

HIV Co-receptor Usage in HIV-related Non-Hodgkin's Lymphoma  

E-Print Network [OSTI]

Access HIV Co-receptor usage in HIV-related non- hodgkin’stested for HIV co- receptor usage and SDF1 3’A polymorphism.CXCR4 and 8 (88.9%) with CCR5 usage, even though most of the

Reid, Erin; Morris, Sheldon R

2012-01-01T23:59:59.000Z

44

Methamphetamine and HIV-1 Tat Down Regulate ?-catenin Signaling: Implications for Methampetamine Abuse and HIV-1 Co-morbidity  

Science Journals Connector (OSTI)

Methamphetamine (Meth) abuse exacerbates HIV-1-associated neurocognitive disorders (HAND). The ... clear but likely involves cooperation between Meth and HIV-1 virotoxins, such as the transactivator of transcript...

Amit Sharma; Xiu-Ti Hu; T. Celeste Napier…

2011-12-01T23:59:59.000Z

45

A Systematic Review of Psychological Functioning of Children Exposed to HIV: Using Evidence to Plan for Tomorrow’s HIV Needs  

Science Journals Connector (OSTI)

Prevention of mother to child transmission of HIV can virtually eliminate paediatric HIV infection. Studies are needed to understand child development outcomes for children exposed to HIV in utero but born HIV...

Lorraine Sherr; Natasha Croome; Katherine Parra Castaneda…

2014-11-01T23:59:59.000Z

46

E-Print Network 3.0 - anti-hiv drug regimens Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

body's natural anti-HIV immune... , there are no therapeutic HIV vaccines approved by the Food and DrugAdministration (FDA). However, therapeutic HIV vaccines... response, people...

47

E-Print Network 3.0 - anti hiv-1 activity Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

to Prevent HIV-1 Infection The rgp120 HIV... virus type 1 (HIV-1) infection. ... Source: Gilbert, Peter - Fred Hutchinson Cancer Research Center & Department of Biostatistics,...

48

E-Print Network 3.0 - appreciating hiv-1 diversity Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

120 Vaccine to Prevent HIV-1 Infection The rgp120 HIV... virus type 1 (HIV-1) ... Source: Gilbert, Peter - Fred Hutchinson Cancer Research Center & Department of Biostatistics,...

49

Mechanisms of HIV-associated neurotoxicity: Tat-induced synapse loss and recovery.  

E-Print Network [OSTI]

??HIV infection is a worldwide pandemic. A debilitating neurological consequence of HIV infection is progressive cognitive decline, known as HIV-associated neurocognitive disorders (HAND). HAND afflicts… (more)

Brunner, Angela Haijung

2013-01-01T23:59:59.000Z

50

Relationships between HIV spread and evolution examined  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3 » 3 » November » Relationships between HIV spread and evolution examined Relationships between HIV spread and evolution examined Thomas Leitner of LANL and collaborators are investigating the development of HIV from the point of contraction onwards. November 14, 2013 Scanning electron micrograph of HIV-1 budding (in green) from cultured lymphocytes. The image has been colored to highlight important features. Photo credit: C. Goldsmith, Centers for Disease Control and Prevention. Scanning electron micrograph of HIV-1 budding (in green) from cultured lymphocytes. The image has been colored to highlight important features. Photo credit: C. Goldsmith, Centers for Disease Control and Prevention. They are examining the relationships between the spread of the virus in a

51

HIV-1 Tat Is a Natively Unfolded Protein THE SOLUTION CONFORMATION AND DYNAMICS OF REDUCED HIV-1 Tat-(172)  

E-Print Network [OSTI]

HIV-1 Tat Is a Natively Unfolded Protein THE SOLUTION CONFORMATION AND DYNAMICS OF REDUCED HIV-1 (transactivation response element (TAR)) formed by the first 59 nucleotides of the HIV-1 RNA (4). Tat stimulates of HIV-dementia (15). A molecular understanding of Tat activity requires a determination of its structure

O'Neil, Joe

52

tat Exon 1 Exhibits Functional Diversity during HIV-1 Subtype C Primary Infection  

Science Journals Connector (OSTI)

...immunodeficiency virus type 1 (HIV-1) Tat is a mediator of viral transcription...However, associations between HIV-1 Tat diversity and functional effects...study to genetically characterize HIV-1 tat during primary HIV-1C infection...

Raabya Rossenkhan; Iain J. MacLeod; Theresa K. Sebunya; Eduardo Castro-Nallar; Mary Fran McLane; Rosemary Musonda; Berhanu A. Gashe; Vlad Novitsky; M. Essex

2013-03-13T23:59:59.000Z

53

E-Print Network 3.0 - african hiv programme Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

3 Sexual prevention of HIV within the couple after prenatal HIV-testing in West Africa Summary: of sexual transmission of HIV occur within stable relationships in high HIV...

54

Low dose irradiation of the early vertebrate embryo and early onset of  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

irradiation of the early vertebrate embryo and early onset of irradiation of the early vertebrate embryo and early onset of tissue aging Lingling Ding Georgia Health Sciences University Abstract There is considerable overlap between cellular and molecular changes that occur in response to low doses of ionizing radiation and those that occur during aging. Both processes are characterized by accumulation of persistent DNA damage (“wear and tear” on the genome), persistent oxidative stress, and depletion of stem/progenitor cells, leading to loss of repair and regenerative capacity. Here we test a hypothesis that exposure to low-dose ionizing radiation accelerates normal, aging-related tissue changes. The work was performed using a small, genetically tractable vertebrate model organism, the Japanese medaka fish (Oryzias latipes). Medaka have a

55

Regulation of HIV-1 gene expression  

SciTech Connect (OSTI)

The quantity and quality of HIV-1 gene expression is temporally controlled by a cascade of sequential regulatory interactions. basal HIV-1 transcription is determined by interaction of cellular regulatory proteins with specific DNA target sequences within the HIV-1 long-terminal repeat. The most notable of these protein: DNA interactions involves NF-{aleph}B, a transcription factor that plays a pivotal role in the activation of genes important for cellular responses to infection and inflammation. A second level of control involves the virally encoded Tat trans-activator. Tat, in combination with as yet unidentified cellular proteins, activates HIV-1 gene expression through a specific interaction with the viral TAR RNA stem-loop target sequence. A final level of regulation is mediated by the viral Rev protein. Rev acts posttranscriptionally to induce the expression of HIV-1 structural proteins and thereby commits HIV-1 to the late, cytopathic phase of the viral replication cycle. Rev activity appears to require a critical, threshold level of Rev protein expression, thus preventing entry into this late phase in cells that are unable to support efficient HIV-1 gene expression. In total, this cascade of regulatory levels allow the HIV-1 provirus to respond appropriately to the intracellular milieu present in each infected cell. In activated cells, the combination of Tat and Rev can stimulate a very high level of viral gene expression and replication. In quiescent or resting cells, in contrast, these same regulatory proteins are predicted to maintain the HIV-1 provirus in a latent or nonproductive state.

Cullen, B.R. (Duke Univ., Durham, NC (United States))

1991-07-01T23:59:59.000Z

56

Epstein-Barr virus immediate-early gene product trans-activates gene expression from the human immunodeficiency virus long terminal repeat  

SciTech Connect (OSTI)

Acquired immunodeficiency syndrome patients are frequently coinfected with Epstein-Barr virus (EBV). In this report, the authors demonstrate that an EBV immediate-early gene product, BamHI MLF1, stimulates expression of the bacterial chloramphenicol acetyltransferase (CAT) gene linked to the human immunodeficiency virus (HIV) promoter. The HIV promoter sequences necessary for trans-activation by EBV do not include the tat-responsive sequences. In addition, in contrast to the other herpesvirus trans-activators previously studied, the EBV BamHI MLF1 gene product appears to function in part by a posttranscriptional mechanism, since it increases pHIV-CAT protein activity more than it increases HIV-CAT mRNA. This ability of an EBV gene product to activate HIV gene expression may have biologic consequences in persons coinfected with both viruses.

Kenney, S.; Kamine, J.; Markovitz, D.; Fenrick, R.; Pagano, J.

1988-03-01T23:59:59.000Z

57

lead-isotope age  

Science Journals Connector (OSTI)

lead-isotope age, lead-lead age [An age in years calculated from the ratio of lead-207 to lead-206, a by-product of the uranium-thorium-lead age method] ? Blei-Isotopen-Alter n

2014-08-01T23:59:59.000Z

58

Cellular Cofactors for HIV-1 Transcription  

Science Journals Connector (OSTI)

Several host cell factors, the chromatin structure of the viral LTR promoter, and the RNA-binding Tat transactivator regulate the transcription of the integrated HIV-1 genome. Transcriptional latency of the pr...

Mauro Giacca

2014-09-01T23:59:59.000Z

59

Neurosyphilis in HIV-infected patients  

Science Journals Connector (OSTI)

To determine the prevalence and the clinical and serological findings of neurosyphilis in HIV-infected patients,Treponema pallidum hemagglutination (TPHA) tests, CD4+ lymphocyte counts and determination of rapid ...

J. Bordón; C. Martinez-Vázquez; M. Alvarez…

1995-10-01T23:59:59.000Z

60

How HIV Infects Cells | Advanced Photon Source  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Simulating Deep Earthquakes in the Laboratory Simulating Deep Earthquakes in the Laboratory A "Sponge" Path to Better Catalysts and Energy Materials Metal Model Mimics Metalloenzymes New Physics in a Copper-Iridium Compound A Key Target for Diabetes Drugs Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed How HIV Infects Cells September 26, 2013 Bookmark and Share The structure of the CCR5 cell surface receptor, which most strains of HIV use to enter human immune cells. This image shows the HIV drug maraviroc grabbing hold of CCR5 in an inactive conformation that prevents HIV from using the receptor to enter cells. (Image by Katya Kadyshevskaya, The Scripps Research Institute)

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

AOC-by-Self-discovery Modeling and Simulation for HIV  

Science Journals Connector (OSTI)

Among HIV, immune cell and drug, exhibit interactions that are usually not well understood and as a result, cannot be accurately modeled. In this paper, Modeling by AOC is to understand the dynamics of HIV infect...

Chunxiao Zhao; Ning Zhong; Ying Hao

2007-01-01T23:59:59.000Z

62

Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins  

DOE Patents [OSTI]

The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Korber, Bette T. (Los Alamos, NM); Perkins, Simon (Los Alamos, NM); Bhattacharya, Tanmoy (Los Alamos, NM); Fischer, William M. (Los Alamos, NM); Theiler, James (Los Alamos, NM); Letvin, Norman (Boston, MA); Haynes, Barton F. (Durham, NC); Hahn, Beatrice H. (Birmingham, AL); Yusim, Karina (Los Alamos, NM); Kuiken, Carla (Los Alamos, NM)

2012-02-21T23:59:59.000Z

63

HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?  

Science Journals Connector (OSTI)

The Tat protein of HIV-1 is a powerful activator of viral ... expression. Besides this essential function at the HIV-1 promoter, the protein also exerts a...Retrovirology...provide possible molecular mechanisms f...

Mauro Giacca

2005-02-01T23:59:59.000Z

64

RNAs selected in vitro by the HIV-2 tat protein  

Science Journals Connector (OSTI)

The Tat proteins of human immunodeficiency virus types 1 (HIV-1) and 2 (HIV-2), termed Tat-1 and Tat-2, respectively, are essential for efficient viral replication. Tat proteins activate viral transcription by bi...

Hyangshuk Rhim; Andrew P. Rice

65

The Role of HIV-1 Proteins in Alzheimer's Disease Pathology.  

E-Print Network [OSTI]

??Prevalence of HIV-associated cognitive impairment is rising, the worst form of which is HIV-associated dementia (HAD). The disease is fuiled by a chronic innate type… (more)

Giunta, Brian Nelson

2011-01-01T23:59:59.000Z

66

Effects of HIV Tat on HPV-containing oral keratinocytes.  

Science Journals Connector (OSTI)

...Res, Volume 46, 2005 Effects of HIV Tat on HPV-containing oral keratinocytes...combined effect of high risk HPV and HIV Tat on malignant cell transformation of...with retrovirus capable of expressing HIV Tat. Expression of Tat in this cell line...

Ji Min Yochim; Reuben Kim; Mo-Kwan Kang; Ki-Hyuk Shin; and No-Hee Park

2005-05-01T23:59:59.000Z

67

Click Dimers To Target HIV TAR RNA Conformation Sunil Kumar,  

E-Print Network [OSTI]

toward HIV TAR RNA, when compared to the fluorescent Tat peptide, and show increased selectivity over acid protein) and regulates the level of transcription of HIV.4,5 The cooperative interaction of TatClick Dimers To Target HIV TAR RNA Conformation Sunil Kumar, Patrick Kellish, W. Edward Robinson

Stuart, Steven J.

68

Cell Host & Microbe HIV Evades RNA Interference Directed at TAR  

E-Print Network [OSTI]

in a sequence-specific manner using shRNAs targeting the viral genome. HIV gag, pol, tat, rev, env, vif, and nefCell Host & Microbe Article HIV Evades RNA Interference Directed at TAR by an Indirect Compensatory@berkeley.edu DOI 10.1016/j.chom.2008.09.008 SUMMARY HIV can rapidly evolve when placed under selective pressure

Schaffer, David V.

69

Early age delamination in concrete pavements made with gravel aggregates  

E-Print Network [OSTI]

of delamination in CRC paving. Three continuous days from November 16 th to 18 th were spent for paving of total ten sections. Field data has been collected through various techniques available to TTI, Texas Department of Transportation (TxDOT), University...

Liu, Juanyu

2009-06-02T23:59:59.000Z

70

Using the social ecological model to understand the contextual factors associated with HIV risk in commercial sex workers at high risk for contracting HIV  

E-Print Network [OSTI]

and the Perceived Risk of Contracting HIV in a Drug Usingsex workers at high risk for contracting HIV A dissertationsex workers at high risk for contracting HIV by Sandra Erika

Larios, Sandra Erika

2008-01-01T23:59:59.000Z

71

Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator.  

Science Journals Connector (OSTI)

...long terminal repeat and the HIV- 1 Tat transactivator V Desai-Yajnik...H)- one], which inhibits Tat-mediated transactivation of HIV-1, also inhibits the functional...long terminal repeat and the HIV-1 Tat transactivator. | Thyroid hormone...

V Desai-Yajnik; E Hadzic; P Modlinger; S Malhotra; G Gechlik; H H Samuels

1995-08-01T23:59:59.000Z

72

E-Print Network 3.0 - age management intervention Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Diploma in Specialist Teaching Summary: in early intervention range in age from birth to 5 years, and have special learning, development... Postgraduate Diploma in...

73

Cellular HIV-1 DNA load predicts HIV-RNA rebound and the outcome of highly active antiretroviral therapy  

E-Print Network [OSTI]

Cellular HIV-1 DNA load predicts HIV-RNA rebound and the outcome of highly active antiretroviral-time PCR assay in multiple samples per patient with a median (interquartile range) follow-up of 76 (45­102) weeks. Results: The median (range) baseline HIV-1 DNA load was 297 (, 10 to 3468) copies per 1 3 106

74

Evolving T-cell vaccine strategies for HIV, the virus with a thousand faces  

SciTech Connect (OSTI)

HIV's rapid global spread and the human suffering it has left in its wake have made AIDS a global heath priority for the 25 years since its discovery. Yet its capacity to rapidly evolve has made combating this virus a tremendous challenge. The obstacles to creating an effective HIV vaccine are formidable, but there are advances in the field on many fronts, in terms of novel vectors, adjuvants, and antigen design strategies. SIV live attenuated vaccine models are able to confer protection against heterologous challenge, and this continues to provide opportunities to explore the biological underpinnings of a protective effect (9). More indirect, but equally important, is new understanding regarding the biology of acute infection (43), the role of immune response in long-term non-progression (6,62, 81), and defining characteristics of broadly neutralizing antibodies (4). In this review we will focus on summarizing strategies directed towards a single issue, that of contending with HIV variation in terms of designing aT-cell vaccine. The strategies that prove most effective in this area can ultimately be combined with the best strategies under development in other areas, with the hope of ultimately converging on a viable vaccine candidate. Only two large HIV vaccine efficacy trials have been completed and both have failed to prevent infection or confer a benefit to infected individual (23,34), but there is ample reason to continue our efforts. A historic breakthrough came in 1996, when it was realized that although the virus could escape from a single antiretroviral (ARV) therapy, it could be thwarted by a combination of medications that simultaneously targeted different parts of the virus (HAART) (38). This revelation came after 15 years of research, thought, and clinical testing; to enable that vital progress the research and clinical communities had to first define and understand, then develop a strategy to counter, the remarkable evolutionary potential of the virus. HAART, for the first time, provided an effective treatment to help those with living with HIV stay healthy. Nonetheless, the treatment has limitations. People with HIV face a lifetime of expensive daily multi-drug regimens, often with side effects; drug resistance at the individual and population level are issues (56); and universal access, despite substantial progress, is a dream not yet realized for many of the millions of the world's poor who are living with HIV (68). These issues, combined with the growing numbers of people infected globally and impact of HIV on society, make the development of an HIV vaccine or a prophylactic prevention strategy a crucial if elusive goal. In some ways, the history of HIV vaccine deVelopment has paralleled the early stages of designing effective therapy. We had to test the simple strategies first, but meanwhile the story of the impact of diversity from an immunological perspective is still unfolding, and novel ideas countermeasures are being explored.

Korber, Bette [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

75

Early strawn biostratigraphy: What is the Caddo  

SciTech Connect (OSTI)

Caddo limestone is used to describe parts of the lower Strawn limestone on the Eastern shelf. The lower Strawn limestone as generally deposited on an eroded Ellenburger surface, but may overlie eroded Mississippian or even Atokan rocks preserved in topographic lows on the Ellenburger surface. Above the Caddo limestone is a sequence of clastics overlain by the Goen Limestone of early Strawn age. The Goen Limestone, in turn, is overlain by clastics which are overlain by the late Strawn Capps Limestone. As long as knowledge of fusulinid zonation was restricted to rocks of early Cherokee, late Cherokee, and Marmaton age, regional correlations of these carbonate units were manageable. With refinement of zonation, however, the Caddo, Goen, and Capps limestones can be subdivided into discrete units of different age. In each of these age zones, the units are further divisible on the basis of environments of deposition and subsequent diagenesis. Current results indicate that the early Strawn carbonates are cyclical and were deposited during numerous glacio-eustatic sea level fluctuations.

Reid, A.M.

1987-02-01T23:59:59.000Z

76

Evaluation of a computer-based system using cell phones for hiv positive people in peru  

Science Journals Connector (OSTI)

HIV is one of the biggest infectious killers worldwide. To prevent disease progression and avoid development of resistant strains to HIV, people living with HIV must adhere to complicated antiretroviral therapy (ART). Yet, in Peru, where ART has recently ...

Walter H. Curioso / Wanda Pratt

2012-01-01T23:59:59.000Z

77

E-Print Network 3.0 - ao hiv em Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Ex Vivo-Expanded Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Infusion in HIV-Infected Patients Summary: , Edwards lack of disease in HIV-1-infected...

78

Liver histopathology in patients with concurrent chronic hepatitis C and HIV infection  

Science Journals Connector (OSTI)

To investigate the influence of human immunodeficiency virus (HIV) coinfection on preexisting long-term chronic C hepatitis (HCV) 68 liver biopsies from 22 HIV/HCV-coinfected, 13 HIV and 33 HCV-monoinfected pa...

E. Bierhoff; H. -P. Fischer; E. Willsch; J. Rockstroh; U. Spengler…

1997-04-01T23:59:59.000Z

79

Low dose rectal inoculation of rhesus macaques by SIV SME660 or SIV MAC251 recapitulates human mucosal infection by HIV-1  

SciTech Connect (OSTI)

Recently, we developed a novel approach to the identification of transmitted or early founder HIV -1 genomes in acutely infected humans based on single genome amplification and sequencing. Here we tested this approach in 18 acutely infected Indian rhesus macaques to determine the molecular features of SIV transmission. Animals were inoculated intrarectally (IR) or intravenously (IV) with stocks of SIVmac251 or SIVsmE660 that exhibited sequence diversity typical of early-chronic HIV -1 infection. 987 full-length SIV env sequences (median of 48 per animal) were determined from plasma virion RNA one to five weeks after infection. IR inoculation was followed by productive infection by one or few viruses (median 1; range 1-5) that diversified randomly with near star-like phylogeny and a Poisson distribution of mutations. Consensus viral sequences from ramp-up and peak viremia were identical to viruses found in the inocula or differed from them by only one or few nuc1eotides, providing direct evidence that early plasma viral sequences coalesce to transmitted/founder virus( es). IV infection was approximately 10,000-fold more efficient than IR infection, and viruses transmitted by either route represented the full genetic spectra of the inocula. These findings identify key similarities in mucosal transmission and early diversification between SIV and HIV -1.

Koraber, Bette [Los Alamos National Laboratory; Perelson, Alan [Los Alamos National Laboratory; Hraber, Peter [Los Alamos National Laboratory; Giorgi, E [Los Alamos National Laboratory; Bhattacharya, T [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

80

Jembrana Disease Virus Tat Can Regulate Human Immunodeficiency Virus (HIV) Long Terminal Repeat-Directed Gene Expression and Can Substitute for HIV Tat in Viral Replication  

Science Journals Connector (OSTI)

...Expression and Can Substitute for HIV Tat in Viral Replication Hexin Chen Jun...virus (HIV) LTR. In contrast, HIV Tat cannot reciprocally activate the JDV...to but not the same as that of the HIV Tat. To further study the similarity...

Hexin Chen; Jun He; Steven Fong; Graham Wilcox; Charles Wood

2000-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

HIV-1 TAT IS A NATIVELY UNFOLDED PROTEIN: THE SOLUTION CONFORMATION AND DYNAMICS OF REDUCED HIV-1 TAT1-72 BY NMR  

E-Print Network [OSTI]

1 HIV-1 TAT IS A NATIVELY UNFOLDED PROTEIN: THE SOLUTION CONFORMATION AND DYNAMICS OF REDUCED HIV-1 59 nucleotides of the HIV-1 RNA (4). Tat stimulates elongation of full-length transcripts implicated in HIV-1 latency (1). Tat may also be involved in derepression of heterochromatin, transcription

O'Neil, Joe

82

E-Print Network 3.0 - amastigotes enhance hiv-1 Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

120 Vaccine to Prevent HIV-1 Infection The rgp120 HIV... virus type 1 ... Source: Gilbert, Peter - Fred Hutchinson Cancer Research Center & Department of Biostatistics,...

83

E-Print Network 3.0 - access hiv-1 test Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Strains in Newly- Summary: Cellular HIV-1 DNA Levels in Drug Sensitive Strains Are Equivalent to Those in Drug Resistant... , Leuven, Belgium Abstract Background: HIV-1...

84

E-Print Network 3.0 - antiretroviral hiv post-exposure Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

HIV in Summary: EDITORIAL REVIEW The antiretroviral rollout and drug-resistant HIV in Africa: insights from... of this plan is to provide antiretroviral treatment to millions of...

85

HIV-AIDS Information Resources from the NLM - ACIO  

SciTech Connect (OSTI)

As the treatment and management of HIV/AIDS continues to evolve with new scientific breakthroughs, treatment discoveries, and management challenges, it is difficult for people living with HIV/AIDS and those who care for them to keep up with the latest information on HIV/AIDS screening and testing, prevention, treatment, and research. The National Library of Medicine (NLM), of the National Institutes of Health, has a wealth of health information resources freely available on the Internet to address these needs.

Templin-Branner, W.

2010-10-01T23:59:59.000Z

86

Emergence of HIV-1 Drug Resistance During Antiretroviral Treatment  

E-Print Network [OSTI]

Bulletin of Mathematical Biology (2007). DOI 10.1007/s11538-007-9203-3. ORIGINAL ARTICLE. Emergence of HIV-1 Drug Resistance During Antiretroviral.

2007-08-22T23:59:59.000Z

87

Early Station Costs Questionnaire  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Early Station Costs Questionnaire Early Station Costs Questionnaire Marc Melaina Hydrogen Technologies and Systems Center Market Readiness Workshop February 16-17th, 2011 Washington, DC Questionnaire Goals * The Early Station Costs questionnaire provides an anonymous mechanism for organizations with direct experience with hydrogen station costs to provide feedback on current costs, near-term costs, economies of scale, and R&D priorities. * This feedback serves the hydrogen community and government agencies by increasing awareness of the status of refueling infrastructure costs National Renewable Energy Laboratory Innovation for Our Energy Future Questions for Market Readiness Workshop Attendees * Are these questions the right ones to be asking?

88

HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment  

E-Print Network [OSTI]

mechanism inhibits HIV-1 and Ebola virus particle releasebudding is antagonized by the Ebola glycoprotein. Proc NatlKG, Oldenburg J, Cannon PM: Ebola glycoprotein counteracts

2010-01-01T23:59:59.000Z

89

Pain is associated with risky drinking over time among HIV-infected persons in St. Petersburg, Russia  

Science Journals Connector (OSTI)

AbstractBackground Pain is highly prevalent among persons with HIV. Alcohol may be used to “self-medicate” pain. This study examined the association between pain and risky alcohol use over time in a cohort of HIV-infected Russian drinkers. Methods This secondary analysis utilized longitudinal data from a randomized trial of a behavioral intervention. Subjects included HIV-infected adults who reported past 6-month risky drinking and unprotected sex and were recruited from HIV and addiction treatment sites in St. Petersburg, Russia. The main independent variable was pain that at least moderately interfered with daily living. The primary outcome was past month risky drinking amounts based on NIAAA guidelines. General estimating equations (GEE) logistic regression models were used to calculate odds ratios and 95% confidence intervals for the association between pain and risky drinking over time (i.e., baseline, 6 and 12 months), adjusting for potential confounders. Results Baseline characteristics of participants (n = 699) were mean age of 30 (SD ±5) years, 41% female, and 22% <9th grade education. Nearly one quarter (24%) had a CD4 cell count <200 cells/?l, and only 17% were on antiretroviral therapy. Nearly half (46%) reported at least moderate pain interference in the past month and 81% were drinking risky amounts. In adjusted longitudinal GEE models, pain was significantly associated with greater odds of reporting past month risky drinking (AOR = 1.34, 95% CI: 1.05–1.71, p value = 0.02). Conclusions Among a cohort of HIV-infected Russian drinkers, pain that at least moderately interfered with daily living was associated with higher odds of reporting risky drinking amounts over time.

Judith I. Tsui; Debbie M. Cheng; Sharon M. Coleman; Marlene C. Lira; Elena Blokhina; Carly Bridden; Evgeny Krupitsky; Jeffrey H. Samet

2014-01-01T23:59:59.000Z

90

Determining age of whales  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Determining age of whales Determining age of whales Name: Bruce W Walkey Age: N/A Location: N/A Country: N/A Date: N/A Question: While browsing through the Internet, I came upon a question by two fifth grade students. Their question got me thinking and now I pose it to you. How can you determine the age of whales? Since they are mammals, can the methods that are used on humans be used on whales? What are some tests that can be done on bones or tissues to determine age? Looking forward to your reply. Replies: Although it is difficult to determine the age of whales (unless they are born in captivity and we know their birth date), several methods have been commonly used: 1) (if female) the examination of the ovaries 2) Examination of the ridges on baleen, which are not uniform in size and analogous to tree rings. The problem with this is that baleen wears away over time. 3) Studying layers of ossification in an ear bone is probably the most accurate method of aging, since internal bones don't wear away. The biggest problem with aging methods is that they usually require that you are dissecting the animal, and often, we would like a method of aging for live active animals. The best we can do here is to compare the size and markings of whales of known age to those found in the wild. Great question!

91

Early American Naval Sigint  

Science Journals Connector (OSTI)

After the Battle of Midway, Laurance Safford, The primary source on early USN Comint work is the booklet US Naval Communications Intelligence Activities by Laurance Safford, J. N. Wenger and at le...

Peter Donovan; John Mack

2014-01-01T23:59:59.000Z

92

AOC-by-self-discovery modeling and simulation for HIV  

Science Journals Connector (OSTI)

Among HIV, immune cell and drug, exhibit interactions that are usually not well understood and as a result, cannot be accurately modeled. In this paper, Modeling by AOC is to understand the dynamics of HIV infection and treatment. The use of AOC-by-self-discovery ...

Chunxiao Zhao; Ning Zhong; Ying Hao

2007-09-01T23:59:59.000Z

93

Iron chelators ICL670 and 311 inhibit HIV-1 transcription  

SciTech Connect (OSTI)

HIV-1 replication is induced by an excess of iron and iron chelation by desferrioxamine (DFO) inhibits viral replication by reducing proliferation of infected cells. Treatment of cells with DFO and 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone (311) inhibit expression of proteins that regulate cell-cycle progression, including cycle-dependent kinase 2 (CDK2). Our recent studies showed that CDK2 participates in HIV-1 transcription and viral replication suggesting that inhibition of CDK2 by iron chelators might also affect HIV-1 transcription. Here we evaluated the effect of a clinically approved orally effective iron chelator, 4-[3,5-bis-(hydroxyphenyl)-1,2,4-triazol-1-yl]-benzoic acid (ICL670) and 311 on HIV-1 transcription. Both ICL670 and 311 inhibited Tat-induced HIV-1 transcription in CEM-T cells, 293T and HeLa cells. Neither ICL670 nor 311 induced cytotoxicity at concentrations that inhibited HIV-1 transcription. The chelators decreased cellular activity of CDK2 and reduced HIV-1 Tat phosphorylation by CDK2. Neither ICL670A or 311 decreased CDK9 protein level but significantly reduced association of CDK9 with cyclin T1 and reduced phosphorylation of Ser-2 residues of RNA polymerase II C-terminal domain. In conclusion, our findings add to the evidence that iron chelators can inhibit HIV-1 transcription by deregulating CDK2 and CDK9. Further consideration should be given to the development of iron chelators for future anti-retroviral therapeutics.

Debebe, Zufan; Ammosova, Tatyana [Center for Sickle Cell Disease, Howard University College of Medicine, 520 W. St., N.W., Washington, DC 20060 (United States); Jerebtsova, Marina [Children's National Medical Center, CRI Center for Cancer and Immunology, 111 Michigan Ave., N.W., Washington, DC 20060 (United States); Kurantsin-Mills, Joseph [Department of Biophysics and Physiology, Howard University College of Medicine, 520 W. St., N.W., Washington, DC 20060 (United States); Niu, Xiaomei; Charles, Sharroya [Center for Sickle Cell Disease, Howard University College of Medicine, 520 W. St., N.W., Washington, DC 20060 (United States); Richardson, Des R. [Iron Metabolism and Chelation Program, Department of Pathology, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, 2006 Australia (Australia); Ray, Patricio E. [Children's National Medical Center, CRI Center for Cancer and Immunology, 111 Michigan Ave., N.W., Washington, DC 20060 (United States); Gordeuk, Victor R. [Center for Sickle Cell Disease, Howard University College of Medicine, 520 W. St., N.W., Washington, DC 20060 (United States); Nekhai, Sergei [Center for Sickle Cell Disease, Howard University College of Medicine, 520 W. St., N.W., Washington, DC 20060 (United States); Department of Biochemistry and Molecular Biology, Howard University College of Medicine, 520 W. St., N.W., Washington, DC 20060 (United States)], E-mail: snekhai@howard.edu

2007-10-25T23:59:59.000Z

94

RESEARCH Open Access HIV-1 Tat protein binds to TLR4-MD2 and signals  

E-Print Network [OSTI]

RESEARCH Open Access HIV-1 Tat protein binds to TLR4-MD2 and signals to induce TNF- and IL-10 Nawal in a TLR4 dependent manner. Conclusions: Collectively, our data showed for the first time that, HIV-1 Tat progression. Keywords: HIV-1, TLR4, Tat, IL-10, TNF- Background HIV-1 infects numerous cells of the immune

Boyer, Edmond

95

HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold  

E-Print Network [OSTI]

HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold Seemay for review October 2, 2012) The HIV-1 Tat protein stimulates viral gene expression by recruiting human genome, HIV infection is hypersensitive to elongation defects. The HIV-1 Tat protein recruits active P

Martin, Gail

96

Regulation of the Human Endogenous Retrovirus K (HML-2) Transcriptome by the HIV-1 Tat Protein  

Science Journals Connector (OSTI)

...HML-2) Transcriptome by the HIV-1 Tat Protein Marta J. Gonzalez-Hernandez...endogenous retroviral sequences. As the HIV-1 Tat protein activates the overall expression...with HIV-1, in part due to the HIV-1 Tat protein. The findings reported...

Marta J. Gonzalez-Hernandez; James D. Cavalcoli; Maureen A. Sartor; Rafael Contreras-Galindo; Fan Meng; Manhong Dai; Derek Dube; Anjan K. Saha; Scott D. Gitlin; Gilbert S. Omenn; Mark H. Kaplan; David M. Markovitz

2014-05-28T23:59:59.000Z

97

Parylene C Aging Studies.  

SciTech Connect (OSTI)

Parylene C is used in a device because of its conformable deposition and other advantages. Techniques to study Parylene C aging were developed, and %22lessons learned%22 that could be utilized for future studies are the result of this initial study. Differential Scanning Calorimetry yielded temperature ranges for Parylene C aging as well as post-deposition treatment. Post-deposition techniques are suggested to improve Parylene C performance. Sample preparation was critical to aging regimen. Short-term (~40 days) aging experiments with free standing and ceramic-supported Parylene C films highlighted %22lessons learned%22 which stressed further investigations in order to refine sample preparation (film thickness, single sided uniform coating, machine versus laser cutting, annealing time, temperature) and testing issues (%22necking%22) for robust accelerated aging of Parylene C.

Achyuthan, Komandoor; Sawyer, Patricia Sue.; Mata, Guillermo Adrian; White II, Gregory Von; Bernstein, Robert

2014-09-01T23:59:59.000Z

98

Co-infecçăo HIV-1/Tripanossomatídeos em macrófagos humanos: efeito da infecçăo pelo HIV-1 e da proteína Tat do HIV-1 sobre a replicaçăo parasitária.  

E-Print Network [OSTI]

??Protozoários parasitos aparecem como co-patógenos em infecçőes pelo vírus da imunodeficięncia humana (HIV)-1, resultando em um aumento mútuo na replicaçăo viral e parasitária, e facilitando… (more)

Victor Barreto de Souza Brasil Silva

2009-01-01T23:59:59.000Z

99

Identification of full-length transmitted/founder viruses and their progeny in primary HIV-1 infection  

SciTech Connect (OSTI)

Identification of transmitted/founder virus genomes and their progeny by is a novel strategy for probing the molecular basis of HIV-1 transmission and for evaluating the genetic imprint of viral and host factors that act to constrain or facilitate virus replication. Here, we show in a cohort of twelve acutely infected subjects (9 clade B; 3 clade C), that complete genomic sequences of transmitted/founder viruses could be inferred using single genome amplification of plasma viral RNA, direct amplicon sequencing, and a model of random virus evolution. This allowed for the precise identification, chemical synthesis, molecular cloning, and biological analysis of those viruses actually responsible for productive clinical infection and for a comprehensive mapping of sequential viral genomes and proteomes for mutations that are necessary or incidental to the establishment of HIV-1 persistence. Transmitted/founder viruses were CD4 and CCR5 tropic, replicated preferentially in activated primary T-Iymphocytes but not monocyte-derived macrophages, and were effectively shielded from most heterologous or broadly neutralizing antibodies. By 3 months of infection, the evolving viral quasispecies in three subjects showed mutational fixation at only 2-5 discreet genomic loci. By 6-12 months, mutational fixation was evident at 18-27 genomic loci. Some, but not all, of these mutations were attributable to virus escape from cytotoxic Tlymphocytes or neutralizing antibodies, suggesting that other viral or host factors may influence early HIV -1 fitness.

Korber, Bette [Los Alamos National Laboratory; Hraber, Peter [Los Alamos National Laboratory; Giorgi, Elena [Los Alamos National Laboratory; Bhattacharya, T [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

100

A discrete element 3' of human immunodeficiency virus 1 (HIV-1) and HIV-2 mRNA initiation sites mediates transcriptional activation by an HIV trans activator  

SciTech Connect (OSTI)

An important point of regulation in the reproductive growth and latency of the human and simian immunodeficiency viruses (HIV and SIV, respectively) is provided by virally encoded trans-activators (tat), proteins capable of dramatically increasing viral gene expression. The mechanism of this autostimulatory pathway has remained unclear, however, with substantial effects having been reported at the level of either mRNA accumulation, translational efficiency, or both. The authors' previous findings indicated that trans-activation results primarily from induction of RNA levels but could not distinguish between the roles of transcriptional rate, RNA stabilization, and RNA transport in this event. In addition, the boundaries of tat-responding elements, which would be valuable in elucidating the mode of tat action, are not precisely known. In this study, HIV-1 and HIV-2 long terminal repeat-directed expression was characterized by using in an vitro nuclear transcription assay to clarify this mechanism, and a detailed mutational analysis was undertaken to localize precisely the sequences participating in this process. Two key findings were revealed: an increased transcription rate was the primary event in tat-mediated activation of HIV-1 and HIV-2, and trans-activation was impaired by mutations in two regions, the TATA box and sequences between +19 to +42, a region lacking enhancer activity. These results implicate a discrete 3' regulatory element in the transcriptional activation of the HIVs.

Jakobovits, A.; Smith, D.H.; Jakobovits, E.B.; Capon, D.J.

1988-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Computer analysis of HIV epitope sequences  

SciTech Connect (OSTI)

Phylogenetic tree analysis provide us with important general information regarding the extent and rate of HIV variation. Currently we are attempting to extend computer analysis and modeling to the V3 loop of the type 2 virus and its simian homologues, especially in light of the prominent role the latter will play in animal model studies. Moreover, it might be possible to attack the slightly similar V4 loop by this approach. However, the strategy relies very heavily upon natural'' information and constraints, thus there exist severe limitations upon the general applicability, in addition to uncertainties with regard to long-range residue interactions. 5 refs., 3 figs.

Gupta, G.; Myers, G.

1990-01-01T23:59:59.000Z

102

Speech understanding and aging  

Science Journals Connector (OSTI)

The increasing age of the population forecasts a corresponding increase in the number of people suffering from hearing loss and who therefore have difficulty with speech communication. This article prepared by the Working Group on Speech Understanding and Aging for the Committee on Hearing Bioacoustics and Biomechanics discusses a number of the factors that act on the elderly listener’s ability to understand speech including physiological aging changes in cognitive ability noisy signals and sensory aids. Both sensory and perceptual processes are considered.

Working Group on Speech Understanding and Aging

1988-01-01T23:59:59.000Z

103

Early anaerobic metabolisms  

Science Journals Connector (OSTI)

...would have been available to fuel early-Earth ecosystems. The...array of different plants, algae and cyanobacteria, and since...advantage of the available energy to fuel them. This is reasonable...where hydrogen is used to fuel methanogenesis. The importance...

2006-01-01T23:59:59.000Z

104

Early History of Magnetism  

Science Journals Connector (OSTI)

... 2, Dr. J. B. Kramer read a paper on “The Early History of Magnetism”, in which he discussed the various accounts of the first discovery of a magnet ... accounts of the first discovery of a magnet, and the development of the science of magnetism down to A.D. 1600. His remarks were divided into five sections, the ...

1932-03-19T23:59:59.000Z

105

HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia  

Science Journals Connector (OSTI)

HIV-1 Tat protein is known to be associated with ... develops in almost half of patients infected with HIV-1. HIV-1 Tat can alter glial neuroprotective functions, leading to neurotoxicity within the CNS. HIV-1 Tat

Ritu Mishra; Chintan Chhatbar; Sunit Kumar Singh

2012-06-01T23:59:59.000Z

106

Health Care Provider Attitudes and Beliefs About People Living with HIV: Initial Validation of the Health Care Provider HIV/AIDS Stigma Scale (HPASS)  

Science Journals Connector (OSTI)

HIV stigma is a pressing concern for people living with HIV, and particularly when it is perpetuated by health care providers, as it may affect quality of life and access to health care services. The current s...

Anne C. Wagner; Trevor A. Hart; Kelly E. McShane; Shari Margolese…

2014-12-01T23:59:59.000Z

107

Redundancy and Biological Aging  

Science Journals Connector (OSTI)

...A, THE LONGEVITY AND MORTALITY OF THOROUGHBRED MARES, JOURNALS OF GERONTOLOGY 13 : 342 ( 1958 ). DANCOFF, S.M., INFORMATION THEORY B 263 ( 1953 ). EHRET, C.F., S INFORMATION THEORY 218 ( 1958 ). FAILLA, G, THE AGING PROCESS AND...

Horton A. Johnson

1963-09-06T23:59:59.000Z

108

PEPFAR in Transition — Implications for HIV Care in South Africa  

Science Journals Connector (OSTI)

...anniversary of the creation of the President's Emergency Plan for AIDS Relief (PEPFAR), widely considered the most ambitious and successful global public health program since smallpox eradication. Over the past decade, PEPFAR has funded HIV–AIDS treatment for more than 5 million people in resource-limited... With the U.S. government halving the budget for the President's Emergency Plan for AIDS Relief in South Africa by 2017, the country is transitioning to full ownership of its HIV program. Will the move jeopardize the health of 1.7 million South Africans being treated for HIV?

Katz I.T.Bassett I.V.Wright A.A.

2013-10-10T23:59:59.000Z

109

Clinical Prediction and Diagnosis of Neurosyphilis in HIV-Infected Patients with Early Syphilis  

Science Journals Connector (OSTI)

...Deeks, EE Paxinos, and RW Price. 2005. Cerebrospinal fluid...37. Libois, A , S De Wit, B Poll, F Garcia, E Florence...Deeks SG, Paxinos EE, Price RW. 2005. Cerebrospinal...650. 37. Libois A, De Wit S, Poll B, Garcia F, Florence...

Jeannot Dumaresq; Stéphanie Langevin; Simon Gagnon; Bouchra Serhir; Benoît Deligne; Cécile Tremblay; Raymond S. W. Tsang; Claude Fortin; François Coutlée; Michel Roger

2013-10-02T23:59:59.000Z

110

Cell, Vol. 122, 147155, July 29, 2005, Copyright 2005 by Elsevier Inc. of HIV-1. Their aim was to determine whether HIV-1 lat-  

E-Print Network [OSTI]

Adams and the physiologically low levels of Tat expression upon initial entry of HIV-1 into the host cell. In the model, lowCell, Vol. 122, 147­155, July 29, 2005, Copyright ©2005 by Elsevier Inc. Previews of HIV-1. Their aim was to determine whether HIV-1 lat- And the Noise Played On: ency can be explained

Collins, James J.

111

Tat Protein Induces Human Immunodeficiency Virus Type 1 (HIV-1) Coreceptors and Promotes Infection with both Macrophage-Tropic and T-Lymphotropic HIV-1 Strains  

Science Journals Connector (OSTI)

...respectively. Here we demonstrate that HIV-1 Tat protein, a potent viral transactivator...results define a novel role for Tat in HIV-1 pathogenesis that promotes the...immunodeficiency virus type 1 (HIV-1) Tat protein, a potent viral transactivator...

Lili Huang; Irene Bosch; Wolfgang Hofmann; Joseph Sodroski; Arthur B. Pardee

1998-11-01T23:59:59.000Z

112

Children Are the Wealth of the Poor: Prevention of Mother-to-Child Transmission of HIV in Haiti  

E-Print Network [OSTI]

At roughly two percent, Haiti has one of the highest HIV prevalence rates in the Caribbean. This thesis examines HIV transmission in Haiti, specifically the transmission of HIV from mother to child during pregnancy, labor, ...

Denney, Rachel

2012-08-31T23:59:59.000Z

113

Transition Step during Assembly of HIV Tat:P-TEFb Transcription Complexes and Transfer to TAR RNA  

Science Journals Connector (OSTI)

...Transition Step during Assembly of HIV Tat:P-TEFb Transcription Complexes...bacteriophage lambda N protein, c-Myc, and HIV Tat (14, 16, 60, 84, 86). Studies of HIV Tat, which regulates elongation of the...

Iván D'Orso; Gwendolyn M. Jang; Alexander W. Pastuszak; Tyler B. Faust; Elizabeth Quezada; David S. Booth; Alan D. Frankel

2012-09-24T23:59:59.000Z

114

HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study  

Science Journals Connector (OSTI)

How HIV-1 enter into the eyes remains obscure. We postulated that HIV-1 Tat protein can alter the expression of specific ... the blood retinal barrier, and contributes to HIV trafficking into the eyes. This study...

Ling Bai; Zhenping Zhang; Hui Zhang; Xiumei Li; Qiurong Yu…

2008-06-01T23:59:59.000Z

115

Development of Personality in Early and Middle Adulthood: Set Like Plaster or Persistent Change?  

E-Print Network [OSTI]

Development of Personality in Early and Middle Adulthood: Set Like Plaster or Persistent Change-factor theory proposes the plaster hypothesis: All personality traits stop changing by age 30. In contrast

Pillow, Jonathan

116

Predicting School Readiness for Low-Income Children With Disability Risks Identified Early.  

E-Print Network [OSTI]

This study examined school readiness at kindergarten entry for low-income children whose disability indicators were identified before age 3. Data were collected as part ofthe Early Head Start Research and Evaluation ...

Jeon, Hyun-Joo; Peterson, Carla A.; Wall, Shavaun; Carta, Judith J.; Gayle, Luze; Eshbaugh, Elaine M.; Swanson, Mark

2011-01-01T23:59:59.000Z

117

Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV  

Science Journals Connector (OSTI)

In 2008, 25 years after the human immunodeficiency virus (HIV) was discovered as the then tentative aetiological agent of acquired immune deficiency syndrome (AIDS), exactly 25 anti-HIV compounds have been formally approved for clinical use in the treatment of AIDS. These compounds fall into six categories: nucleoside reverse transcriptase inhibitors (NRTIs: zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine); nucleotide reverse transcriptase inhibitors (NtRTIs: tenofovir); non-nucleoside reverse transcriptase inhibitors (NNRTIs: nevirapine, delavirdine, efavirenz and etravirine); protease inhibitors (PIs: saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, lopinavir, atazanavir, fosamprenavir, tipranavir and darunavir); cell entry inhibitors [fusion inhibitors (FIs: enfuvirtide) and co-receptor inhibitors (CRIs: maraviroc)]; and integrase inhibitors (INIs: raltegravir). These compounds should be used in drug combination regimens to achieve the highest possible benefit, tolerability and compliance and to diminish the risk of resistance development.

Erik De Clercq

2009-01-01T23:59:59.000Z

118

Patterns of Aging  

Science Journals Connector (OSTI)

...maintains that the impending exhaustion of the pool of grow-ing ovarian follicles triggers...size of the initial primordial folli-cle pool. In mammals, during early fetal development...that the rate of loss of the follicular pool during postnatal life is deter-mined...

Katrina L. Kelner; Jean Marx

1996-07-05T23:59:59.000Z

119

An age-structured model for the coupled dynamics of HIV and HSV-2  

E-Print Network [OSTI]

Profesor Asociado a la Facultad de Ingenieria y Ciencias de la Universidad Adolfo Ibanez, Santiago, Chile. Zhilan Feng. Department of Mathematics, Purdue

2014-12-24T23:59:59.000Z

120

LANL researchers use computer modeling to study HIV | National Nuclear  

National Nuclear Security Administration (NNSA)

researchers use computer modeling to study HIV | National Nuclear researchers use computer modeling to study HIV | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > LANL researchers use computer modeling to study HIV LANL researchers use computer modeling to study HIV Posted By Office of Public Affairs Los Alamos National Laboratory researchers are investigating the complex

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Fragment Screen against HIV Protease: Discovery of Two Allosteric...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Y., Moisi, D., Oliveira, M., Turner, D., Wainberg, M. A. & co-investigators of the Quebec Primary Infection Study. (2004) Persistence of multidrug-resistant HIV-1 in primary...

122

Additivity in the Analysis and Design of HIV Protease Inhibitors  

E-Print Network [OSTI]

We explore the applicability of an additive treatment of substituent effects to the analysis and design of HIV protease inhibitors. Affinity data for a set of inhibitors with a common chemical framework were analyzed to ...

Jorissen, Robert N.

123

Decision making in the HIV/AIDS supply chain  

E-Print Network [OSTI]

During the first two decades of HIV/AIDS awareness, the U.S. and foreign governments responded slowly to the crisis. In contrast today, as the pandemic continues, initiatives of nonprofit organizations have dramatically ...

Cao, Elaine Phu

2007-01-01T23:59:59.000Z

124

Emerging nanotechnology approaches for HIV/AIDS treatment and prevention  

E-Print Network [OSTI]

Emerging nanotechnology approaches for HIV/AIDS treatment and prevention The emergence of AIDS effects and is ineffective in patients in whom the virus develops resistance. Nanotechnology of nanotechnology to provide more effective treatment and preven

von Andrian, Ulrich H.

125

HIV immunity study could pave way for vaccine development  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Scientists among duke-led consortium HIV immunity study could pave way for vaccine development Two scientists are among the team recently funded to explore ways to create the...

126

Essays on HIV/AIDS in sub-Saharan Africa  

E-Print Network [OSTI]

HIV-1 Prenvetion SErvices in Dar Es Salaam, Tanzania: Thein Nairobi, Kenya and Dar Es Salaam, Tanzania. ” In bothurban Kenya (13-14%) and Dar es Salaam, Tanzania (10-12%) (

Gong, Erick Joseph

2011-01-01T23:59:59.000Z

127

E-Print Network 3.0 - age distribution genetics Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

10.1534genetics.108.086801 Summary: across all ages. This result implies a genetic trade-off between the two traits in early lifeand may help... of environmental conditions on...

128

E-Print Network 3.0 - age-related retinal degeneration Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

group of early onset blinding and retinal degenerations. Leber congenital amaurosis (LCA)1... day until they were 1 month old. Note the y axis scale. C, age-related...

129

E-Print Network 3.0 - age-related white matter Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

results for: age-related white matter Page: << < 1 2 3 4 5 > >> 1 Assessing Early Brain Development in Neonates by Segmentation of High-Resolution 3T MRI Summary: brain atlas...

130

E-Print Network 3.0 - age-related molecular genetic Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

maculopathy--population-based familial aggregation... , A.R., Snieder, H., Bird, A.C., Gilbert, C.E. and Spector, T.D. (2002) Genetic influence on early age-related... of...

131

Bitcoin and The Age of Bespoke Silicon Michael Bedford Taylor  

E-Print Network [OSTI]

Bitcoin and The Age of Bespoke Silicon Michael Bedford Taylor University of California, San Diego ABSTRACT Recently, the Bitcoin cryptocurrency has been an interna- tional sensation. This paper tells the story of Bitcoin hard- ware: how a group of early-adopters self-organized and fi- nanced the creation

Wang, Deli

132

Unraveling the paradoxes of HIV-associated psoriasis: A review of T-cell subsets and cytokine profiles  

E-Print Network [OSTI]

8. PubMed 28. Mallon E, Bunker CB. HIV-associated psoriasis.Easterbrook PJ, Newson R, Bunker CB. HLA-Cw*0602 and HIV-

Fife, Douglas J; Waller, Jeanette M; Jeffes, Edward W; Koo, John YM

2007-01-01T23:59:59.000Z

133

Mother- to - Child Transmission of HIV and congenital syphilis: A snapshot of an Epidemic in the Republic of Panama.  

E-Print Network [OSTI]

??ABSTRACT Background: Worldwide HIV is going through a feminization and rejuvenation as more women are living with HIV/AIDS, increasing the risk of vertical transmission. Despite… (more)

Jenkins, Lorna Elizabeth

2013-01-01T23:59:59.000Z

134

How HIV infects cells | Argonne National Laboratory  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Science Science Computing, Environment & Life Sciences Energy Engineering & Systems Analysis Photon Sciences Physical Sciences & Engineering Energy Frontier Research Centers Science Highlights Postdoctoral Researchers The brightness and energy of X-ray beams are critical properties for research. The APS Upgrade will make our X-ray beams brighter, meaning more X-rays can be focused onto a smaller, laser-like spot, allowing researchers to gather more data in greater detail in less time. How HIV infects cells October 10, 2013 Tweet EmailPrint In a long-awaited finding, an international team of scientists using high-brightness x-rays from the U.S. Department of Energy Office of Science's Advanced Photon Source at Argonne National Laboratory has determined the high-resolution atomic structure of a cell-surface receptor

135

industrial age automation age access age holistic transformation How is this impacting the ways  

E-Print Network [OSTI]

#12;industrial age automation age access age holistic transformation #12;#12;How is this impacting Educational Resources OER #12;Bring Your Own Device BYOD Communication Anywhere on Any Device At Home

136

Early history of ISNA  

Science Journals Connector (OSTI)

The International Symposia on Nonlinear Acoustics now referred to as ISNA have convened regularly since 1968 bringing together scientists and engineers to report and discuss the latest developments in this branch of nonlinear physics. The fact that this series of symposia is still going strong after more than four decades is testimony that nonlinear acoustics has established itself as a distinct important and vibrant field of research. In this paper we take a look back at the early years of ISNA to recall how it all began and trace the evolution of the symposia into their current form.

Mark F. Hamilton; Thomas G. Muir; David T. Blackstock

2012-01-01T23:59:59.000Z

137

Aging in community  

E-Print Network [OSTI]

Baby Boomers are on the brink of retirement. According to U.S. Census Bureau projections, the number of people aged 65 and over will more than double in the coming decades, growing from 35 million in 2000 to 72 million in ...

Fay, Justin (Justin Thomas)

2008-01-01T23:59:59.000Z

138

Nuclear age thinking  

SciTech Connect (OSTI)

According to the practicalist school, thinking emerges from activity and each human practice is giving food to its own distinctive kinds of perception, conduct, and perspective of the world. The author, while studying and describing developments after the commencement of the nuclear age in many fields of human behavior and knowledge, including the social sciences, particularly psychology and international politics, became an adherent to the practicalist philosophy when he perceived new relevant thoughts coming to his mind at the same time. Indeed writing is a learning experience. He has, therefore, systematically included these thoughts in the following pages and synoptically characterized them in the title: Nuclear Age Thinking. He considers this kind of thinking as automatic, conscious activity which is gradually influencing our choices and decisions. The author has reservations as regards Albert Einstein's saying that the unleashed power of the atom changed everything save our modes of thinking, because the uncontrollability of nuclear energy is apparently in the subconscious of mankind nowadays, influencing the development of a new mode of thinking, and that is the nuclear age thinking which is the subject of this book. Nuclear age thinking drives from the collective fear of extinction of life on earth due to this new power at man's disposal, and it is not only limited to the change in the conventional meaning of the words war and peace.

Depastas, A.N.

1990-01-01T23:59:59.000Z

139

Aging Around the World  

Science Journals Connector (OSTI)

... of the elderly, but has become a diffuse and perhaps unsatisfactory term for all the interrelated proce\tsses of the adult life-span. We do not know, and may never ... is truly 'normal aging'; what we are doing is to identify some of these processes that seem to alter with the passage of time in a unidirectional way, a ...

ALASTAIR HERON

1963-04-06T23:59:59.000Z

140

Patterns of Aging  

Science Journals Connector (OSTI)

...Richardson, in Handbook of the Biology of...The Aging Immune System: Primer and Prospectus...or-gans, or culture systems, in ways that con-found...produce only partial restoration of T cell responses...3. D. C. Powers and R. B. Belshe...R. A. Miller, Handbook of Physiology...

Katrina L. Kelner; Jean Marx

1996-07-05T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Analysis of HIV-1 pol sequences from Panama: Identification of phylogenetic clusters within subtype B and detection of antiretroviral drug resistance mutations  

Science Journals Connector (OSTI)

We report the first study to examine phylogenetic relationships and drug resistance mutations in HIV-1 pol sequences from Panama. For this study, we used plasma RNA samples from 135 HIV-1-infected subjects from Panama, of which 82 (61%) had AIDS and 53 (39%) were asymptomatic drug-naďve individuals. Phylogenetic analyses revealed that 133 (98%) subjects were infected with subtype B viruses and 2 AIDS patients harboured recombinant viruses, CRF02_AG/A3 and CRF12_BF/B, respectively. Using a Bayesian phylogeny inference method, 5 strongly supported clusters of ?5 sequences, designated B-PA1 to B-PA5, were identified within subtype B, together comprising 87 (65.4%) subtype B viruses. Cluster B-PA1 (n = 42) was significantly associated with East Panama and clusters B-PA2 (n = 15) and B-PA4 (n = 10) were associated with West Panama. A Bayesian coalescent analysis indicated that the most recent common ancestors of the four largest clusters were dated in the 1980s and that of the fifth in the early 1990s. The analysis of antiretroviral drug resistance-associated mutations revealed that 8 (9.7%) AIDS patients, all of them antiretroviral drug-experienced, harboured mutations conferring high or intermediate resistance levels to antiretroviral drugs. No drug resistance mutations were detected among the asymptomatic drug-naďve individuals. In conclusion, the phylogenetic analysis of HIV-1 pol sequences from Panama reveals that a majority of subtype B viruses, which are predominant in Panama, branch within well supported intrasubtype phylogenetic clusters, most of them originating in the 1980s, and some with geographical associations, which may reflect either multiple HIV-1 subtype B introductions or the existence of local transmission networks originating in the early epidemic in Panama.

Sara Ahumada-Ruiz; Dario Flores-Figueroa; Iván Toala-González; Michael M. Thomson

2009-01-01T23:59:59.000Z

142

Solid-State NMR Studies of HIV-1 Capsid Protein Assemblies. ...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of HIV-1 Capsid Protein Assemblies. Abstract: In mature HIV-1 virions, the 26.6 kDa CA protein is assembled into a characteristic cone-shaped core (capsid) that encloses the...

143

Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens  

DOE Patents [OSTI]

The present invention relates to mosaic clade M HIV-1 Env polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Korber, Bette T. (Los Alamos, NM); Fischer, William (Los Alamos, NM); Liao, Hua-Xin (Durham, NC); Haynes, Barton F. (Durham, NC); Letvin, Norman (Boston, MA); Hahn; Beatrice H. (Birmingham, AL)

2011-05-31T23:59:59.000Z

144

Special Article: Significant Risk Versus Acceptable Risk in Dental Treatment of HIV-Infected Individuals  

Science Journals Connector (OSTI)

Dentists are obligated to treat HIV-infected individuals by legal and professional code regardless of personal bias, level of training, or area of specialty. Refusal to treat HIV-infected individuals irrespect...

Albert W. Whitehead; John Hlaudy

2002-06-01T23:59:59.000Z

145

HIV-1 Tat trans-activates in the Absence of its Target  

Science Journals Connector (OSTI)

The human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of the ... immunodeficiency disease syndrome (AIDS). Transcription of HIV-1 is regulated by the virally encoded trans-activator, Tat (Varmus,...

Mark J. Selby; B. Matija Peterlin

1991-01-01T23:59:59.000Z

146

E-Print Network 3.0 - anti-dendritic cell hiv Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

COS cells, pgTAT(HIV-1) induces the efficient synthesis... cells (16). The genomic HIV-2 tat ... Source: Le, Shu-Yun - Center for Cancer Research Nanobiology Progam,...

147

E-Print Network 3.0 - acyclovir delays hiv-1 Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

HIV-1genes... .06.006 Stochastic Gene Expression in a Lentiviral Positive-Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic... that the phage's lysislysogeny life-cycle...

148

Bcl-2 upregulation by HIV-1 tat during infection of primary human macrophages in culture  

Science Journals Connector (OSTI)

The ability of cells of the human monocyte/macrophage lineage to host HIV-1 replication while resisting cell death is ... susceptible to apoptosis. Here we report that HIV-1BAL...infection of primary human monocy...

Mingjie Zhang; Xingxiang Li; Xiaowu Pang; Linna Ding…

149

Analysis of HIV-1 Tat effects inXenopus laevis embryos  

Science Journals Connector (OSTI)

Tat is one of the regulatory proteins of the HIV-1 virus. To date, besides the ... activity, a myriad of effects exerted by HIV-1 Tat on cellular and viral genes have been ... present study investigated the in vi...

Dr. Serenella Venanzi; Olivier H. J. Destrée…

150

N-Terminal HIV-1 Tat Nonapeptides as Inhibitors of Dipeptidyl Peptidase IV. Conformational Characterization  

Science Journals Connector (OSTI)

Compared to the N-terminal nonapeptide of the HIV-1 Tat protein as inhibitor of activity of DP ... is supposed to mediate the immunosuppressive effects of HIV-1 Tat, the Ile5 and Leu6 analogues showed strongly re...

Carmen Mrestani-Klaus; Annett Fengler…

2002-01-01T23:59:59.000Z

151

E-Print Network 3.0 - anti-hiv drug combinations Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

of four individual anti-HIV shRNAs might already suffice... to express a single anti-HIV tat shRNA in cultured lymphoma cells and found it ... Source: Kay, Mark A. -...

152

HIV-1 Tat protein and endothelium: From protein/cell interaction to AIDS-associated pathologies  

Science Journals Connector (OSTI)

Tat protein, the transactivating factor of the human immunodeficiency virus type 1 (HIV-1), is a small cationic polypeptide that can be released from HIV-1 infected cells. Extracellular Tat elicits different biol...

Marco Rusnati; Marco Presta

2002-01-01T23:59:59.000Z

153

Extracellular HIV Tat and Tat cysteine rich peptide increase CCR5 expression in monocytes  

Science Journals Connector (OSTI)

In our previous work we reported that HIV Tat and 6 cysteine rich peptides of Tat induce tumor necrosis factor-related apoptosis-induced...et al...., 2003). Here our results showed that HIV Tat and Tat cysteine r...

Zheng Lin; Yang Yi-da; Lu Guo-cai…

2005-07-01T23:59:59.000Z

154

Antibody to HIV-1 Tat protein inhibits the replication of virus in culture  

Science Journals Connector (OSTI)

The HIV-1 transactivator protein Tat is essential for viral replication. Tat is released from infected cells and can be taken up and transactivate HIV-LTR in LTR-CAT transfected cell lines. ... shows that the add...

L. Steinaa; A. M. Sřrensen; J. O. Nielsen; J. E. S. Hansen

1994-01-01T23:59:59.000Z

155

Regulation of HIV-1 Gene Expression by the Transactivator Protein Tat  

Science Journals Connector (OSTI)

The regulation of HIV-1 gene expression is an area of intense investigation. Like all retroviruses, HIV-1 integrates into cellular DNA, and its gene expression is dependent on host cell transcription factors a...

R. B. Gaynor

1995-01-01T23:59:59.000Z

156

Evaluation of HIV-1 Tat induced neurotoxicity in rat cortical cell culture  

Science Journals Connector (OSTI)

In a substantial number of cases, Human Immunodeficiency Virus type 1 (HIV-1) infection causes neuronal cell loss and ... loss. Here we studied the effect of HIV-1 Tat in primary rat neuronal cells as a ... cell ...

Aleida Pérez; Albert W. Probert; Kevin K. W. Wang…

2001-01-01T23:59:59.000Z

157

Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein. Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide...

158

E-Print Network 3.0 - access hiv services Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

HIV Summary: on the prevention of HIV and STIs to women who do not frequently access health care services. Although prenatal care... fees. Mother-infant pairs had access to...

159

E-Print Network 3.0 - africa estimating hiv Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

hiv Search Powered by Explorit Topic List Advanced Search Sample search results for: africa estimating hiv Page: << < 1 2 3 4 5 > >> 1 November 30, 2006, 12:00 AM Three Things...

160

Concrete containment aging study  

SciTech Connect (OSTI)

In 1989, IAEA initiated a pilot study on the management of aging of nuclear power plant components. The Phase I and II studies of concrete containment are discussed. With the data base, plant owners will be able to review and enhance their existing programs. IAEA will analyze data provided by participating plants and the report is scheduled to be released by late 1994 (final report release mid-1995).

Pachner, J. [International Atomic Energy Agency, Vienna (Austria); Tai, T.M. [Bechtel National, Inc., Oak Ridge, TN (United States); Naus, D. [Oak Ridge National Lab., TN (United States)

1994-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

HIV-1 Fusion Peptide Decreases Bending Energy and Promotes Curved Fusion Intermediates  

E-Print Network [OSTI]

HIV-1 Fusion Peptide Decreases Bending Energy and Promotes Curved Fusion Intermediates Stephanie in human immunodeficiency virus (HIV) infection is fusion between the viral envelope and the T x-ray scattering is that the bending modulus KC is greatly reduced upon addition of the HIV fusion

Nagle, John F.

162

HIV Fusion Peptide Penetrates, Disorders, and Softens T-Cell Membrane Mimics  

E-Print Network [OSTI]

HIV Fusion Peptide Penetrates, Disorders, and Softens T-Cell Membrane Mimics Stephanie Tristram of N-terminal gp41 fusion peptide (FP) of human immunodeficiency virus type 1 (HIV-1) with model membranes in order to elucidate how FP leads to fusion of HIV and T-cell membranes. FP constructs were (i

Weliky, David

163

Laboratory Evaluation of a Dual Rapid Immunodiagnostic Test for HIV and Syphilis Infection  

Science Journals Connector (OSTI)

...Evaluation of a Dual Rapid Immunodiagnostic Test for HIV and Syphilis Infection Claire C...Angeles, Los Angeles CA, USA New dual tests for HIV and syphilis have been developed...performance of a dual rapid immunodiagnostic test for HIV and syphilis. Our evaluation showed...

Claire C. Bristow; Segundo R. Leon; Lourdes B. Ramos; Silver K. Vargas; Juan A. Flores; Kelika A. Konda; Carlos F. Caceres; Jeffrey D. Klausner

2014-11-05T23:59:59.000Z

164

Laboratory Evaluation of Three Rapid Diagnostic Tests for Dual Detection of HIV and Treponema pallidum Antibodies  

Science Journals Connector (OSTI)

...Laboratory Evaluation of Three Rapid Diagnostic Tests for Dual Detection of HIV and Treponema...dual HIV and syphilis rapid diagnostic tests (RDTs) was evaluated for 150 patient...FDA-approved HIV-1 RNA nucleic acid test (NAT) (11). Reference methods for...

Romney M. Humphries; Jennifer S. Woo; Jun Ho Chung; Anita Sokovic; Claire C. Bristow; Jeffrey D. Klausner

2014-10-08T23:59:59.000Z

165

Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal  

E-Print Network [OSTI]

Health and Interventions to Reduce Perinatal HIV Transmission in the United States Developed by the HHS Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission--A Working: Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission

Levin, Judith G.

166

Translocation of HIV TAT peptide and analogues induced by multiplexed membrane  

E-Print Network [OSTI]

Translocation of HIV TAT peptide and analogues induced by multiplexed membrane and cytoskeletal), such as the HIV TAT peptide, are able to translocate across cellular membranes efficiently. A number of mechanisms acids) and cationic. Examples include the TAT peptide from HIV, antennapedia (ANTP) from Drosophila

Cheng, Jianjun

167

Recognition of HIV TAR RNA by triazole linked neomycin dimers Sunil Kumar, Dev P. Arya  

E-Print Network [OSTI]

located at 50 -end of all nascent HIV-1 transcripts interacts with a key regulatory protein, Tat protein, (a 86 amino acid protein) and regulates the transcription of HIV virus. TAR RNA­Tat proteinRecognition of HIV TAR RNA by triazole linked neomycin dimers Sunil Kumar, Dev P. Arya Laboratory

Stuart, Steven J.

168

Inhibition of HIV-1 virus replication using small soluble Tat peptides Emmanuel Agbottah a  

E-Print Network [OSTI]

Inhibition of HIV-1 virus replication using small soluble Tat peptides Emmanuel Agbottah of viral resistance. During HIV infection, the viral activator Tat is needed for viral progeny formation in vivo. D 2005 Elsevier Inc. All rights reserved. Keywords: HIV; Cyclin-dependent kinase; Tat; Peptide

Zeng, Chen

169

PREDICTION OF INTERACTIONS BETWEEN HIV-1 AND HUMAN PROTEINS BY INFORMATION INTEGRATION  

E-Print Network [OSTI]

the predicted interactions was for example the pair, HIV-1 protein tat and human vitamin D receptorPREDICTION OF INTERACTIONS BETWEEN HIV-1 AND HUMAN PROTEINS BY INFORMATION INTEGRATION OZNUR TASTAN of Pittsburgh, 15260, Pittsburgh, PA USA. Human immunodeficiency virus-1 (HIV-1) in acquired immune deficiency

170

ORAL PRESENTATION Open Access HIV-1 Tat complexes reveal subunit composition  

E-Print Network [OSTI]

ORAL PRESENTATION Open Access HIV-1 Tat complexes reveal subunit composition of active P this article as: Sobhian et al.: HIV-1 Tat complexes reveal subunit composition of active P-TEFb and stable2 , M Benkirane1 From International AIDS Society's Workshop "Towards a Cure": HIV Reservoirs

Paris-Sud XI, Université de

171

POSTER PRESENTATION Open Access HIV-1 Tat protein induces the production of IDO in  

E-Print Network [OSTI]

POSTER PRESENTATION Open Access HIV-1 Tat protein induces the production of IDO in human monocyte.1186/1742-4690-10-S1-P113 Cite this article as: Planes and Bahraoui: HIV-1 Tat protein induces the production of IDO Cambridge, UK. 16-18 September 2013 Background During HIV-1 infection, an increase of indoleamine 2

Boyer, Edmond

172

HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells  

Science Journals Connector (OSTI)

...Therapeutics, Targets, and Development HIV-Tat protein transduction domain specifically...suggested. Here, we show that the HIV-Tat transduction peptide, which is known...CHO MGBG) displayed unperturbed HIV-Tat uptake activity compared with wild-type...

Katrin Mani; Staffan Sandgren; Johanna Lilja; Fang Cheng; Katrin Svensson; Lo Persson; and Mattias Belting

2007-02-01T23:59:59.000Z

173

Intracellular transactivation of HIV can account for the decelerating decay of virus load during drug therapy  

E-Print Network [OSTI]

. In HIV, the protein trans-activator of transcription (Tat) has been found to have a major role withinIntracellular transactivation of HIV can account for the decelerating decay of virus load during quantitative issues of HIV replication. However, several parts of the viral life cycle remain elusive. One

Utrecht, Universiteit

174

Abortive HIV Infection Mediates CD4 T-Cell Depletion and Inflammation in Human Lymphoid Tissue  

E-Print Network [OSTI]

factors like HIV-1 Tat, Vpr, and Nef released from infected cells (Schindler et al., 2006; Westendorp etAbortive HIV Infection Mediates CD4 T-Cell Depletion and Inflammation in Human Lymphoid Tissue 94143 Summary The mechanism by which CD4 T-cells are depleted in HIV-infected hosts remains poorly

Levin, Judith G.

175

Identification of Host Proteins Required for HIV Infection Through a Functional  

E-Print Network [OSTI]

) in the proviral RNA and promotes elongation by recruiting cyclin T1, HIV-1 Tat specific factor 1 (HTATSF1 was optimized with siRNAs against Tat, CD4, and Rab9p40; Rab9p40 is required for HIV particle release (5). siIdentification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

Lieberman, Judy

176

The HIV-1 Tat Protein Has a Versatile Role in Activating Viral Transcription  

Science Journals Connector (OSTI)

...Regulation of Viral Gene Expression The HIV-1 Tat Protein Has a Versatile Role in...assess in replication studies with Tat-mutated HIV-1 variants because of the dominant...Upon long-term culturing, the Tat-minus HIV-rtTA variant acquired mutations...

Atze T. Das; Alex Harwig; Ben Berkhout

2011-07-13T23:59:59.000Z

177

Effect of transcription peptide inhibitors on HIV-1 replication Rachel Van Duyne a  

E-Print Network [OSTI]

and maintain latent infection. Specifically, the HIV-1 viral protein Tat increases viral transcription. Published by Elsevier Inc. Keywords: HIV Cyclin-dependent kinase Tat Peptide inhibitor Transcription CellEffect of transcription peptide inhibitors on HIV-1 replication Rachel Van Duyne a , Jessica

Zeng, Chen

178

Polymorphisms of HIV-2 integrase and selection of resistance to raltegravir  

Science Journals Connector (OSTI)

HIV-2 polymorphisms from 45 INI-naive patients are described. Conserved regions as well as frequencies of HIV-2 IN polymorphisms were comparable to HIV-1. Two new mutations (Q91R and I175M) that conferred high resistance to RAL were selected in vitro, which might affect therapeutic outcome.

Danielle Perez-Bercoff; Perrine Triqueneaux; Christine Lambert; Aboubacar Oumar; Anne-Marie Ternes; Sounkalo Dao; Patrick Goubau; Jean-Claude Schmit; Jean Ruelle

2010-11-29T23:59:59.000Z

179

Viscosity and dissipation - early stages  

E-Print Network [OSTI]

A very early start up time of the hydrodynamic evolution is needed in order to reproduce observations from relativistic heavy-ion collisions experiments. At such early times the systems is still not locally equilibrated. Another source of deviations from local equilibrium is the viscosity of the fluid. We study these effects at very early times to obtain a dynamical prescription for the transition from an early 2-dimensional expansion to a nearly equilibrated 3-dimensional expansion at latter stages. The role of viscosity at latter stages of the evolution is also illustrated.

P. Bozek

2009-01-15T23:59:59.000Z

180

Early Customer Involvement in Innovation.  

E-Print Network [OSTI]

?? The Front End of innovation (FEI) or early innovation presents one of the greatest opportunities for improving an entire innovation process in any firm.… (more)

Penn, Sylvain Bienvenu

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

receive DOE Early Career Award  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

hydrological controls on carbon cycling in flood plain ecosystems into Earth System Models (ESM). "The DOE Early Career Research Award represents both a significant honor...

182

Ice age paleotopography  

SciTech Connect (OSTI)

A gravitationally self-consistent theory of postglacial relative sea level change is used to infer the variation of surface ice and water cover since the Last Glacial Maximum (LGM). The results show that LGM ice volume was approximately 35 percent lower than suggested by the CLIMAP reconstruction and the maximum heights of the main Laurentian and Fennoscandian ice complexes are inferred to have been commensurately lower with respect to sea level. Use of these Ice Age boundary conditions in atmospheric general circulation models will yield climates that differ significantly from those previously inferred on the basis of the CLIMAP data set.

Peltier, W.R. (Univ. of Toronto, Ontario (Canada))

1994-07-08T23:59:59.000Z

183

Retinal Diseases: Age-Related Macular Degeneration and Retinitis Pigmentosa  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Retinal Diseases: Age-Related Macular Degeneration and Retinitis Pigmentosa Retinal Diseases: Age-Related Macular Degeneration and Retinitis Pigmentosa Age-related macular degeneration (AMD) is an eye disease primarily affecting the central vision regions in people age 60 and older. According to the Macular Degeneration Research Fund, a case of AMD is diagnosed in the United States every 3 minutes. Each year, 1.2 million of the estimated 12 million people with AMD will suffer severe vision loss. Patients with AMD have dark areas in their vision caused by fluid leakage or bleeding in the macula, the center of the retina that produces the sharpest vision. The brain initially compensates for these dark patches. Early cellular dysfunction or spotting in the macula may go undetected until the disease is in advanced stages.

184

Early Entrance Coproduction Plant  

SciTech Connect (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or other carbonaceous feedstocks. The objectives of Phase I were to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan for implementation in Phase II; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology that produces high-value products, particularly those that are critical to our domestic fuel and power requirements. The work performed under Phase II will resolve critical knowledge and technology gaps on the integration of gasification and downstream processing to coproduce some combination of power, fuels, and chemicals from coal and/or other carbonaceous feedstocks. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation.

Mushtaq Ahmed; John H. Anderson; Earl R. Berry; Troy Raybold; Lalit S. Shah; Kenneth A. Yackly

2004-01-26T23:59:59.000Z

185

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or other carbonaceous feedstocks. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Testing Plan (RD and T) for implementation in Phase II. The objective of Phase II is to implement the RD and T as outlined in the Phase I RD and T Plan to enhance the development and commercial acceptance of coproduction technology that produces high-value products, particularly those that are critical to our domestic fuel and power requirements. The project will resolve critical knowledge and technology gaps on the integration of gasification and downstream processing to coproduce some combination of power, fuels, and chemicals from coal and/or other carbonaceous feedstocks. The objective of Phase III is to develop an engineering design package and a financing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information that will be needed to move the EECP forward to detailed design, construction, and operation by industry.

John S. Abughazaleh; Mushtaq Ahmed; Ashok Anand; John H. Anderson; Charles Benham; Fred D. Brent; Thomas E. Chance; William K. Davis; Raymond F. Drnevich; Larry Hall; Ming He; Stephen A. Lang; Jimmy O. Ong; Sarah J. Patel; George Potoczniak; Adela G. Sanchez; Charles H. Schrader; Lalit S. Shah; Phil J. Shires; Rae Song

2001-02-15T23:59:59.000Z

186

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or other carbonaceous feedstock. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Testing Plan (RD and T) for implementation in Phase II. The objective of Phase II is to implement the RD and T as outlined in the Phase I RD and T Plan to enhance the development and commercial acceptance of coproduction technology that produces high-value products, particularly those that are critical to our domestic fuel and power requirements. The project will resolve critical knowledge and technology gaps on the integration of gasification and downstream processing to coproduce some combination of power, fuels, and chemicals from coal and other feedstocks. The objective of Phase III is to develop an engineering design package and a financing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information that will be needed to move the EECP forward to detailed design, construction, and operation by industry.

John S. Abughazaleh; Mushtaq Ahmed; Ashok Anand; John H. Anderson; Charles Benham; Fred D. Brent; Thomas E. Chance; William K. Davis; Raymond F. Drnevich; Larry Hall; Ming He; Stephen A. Lang; Jimmy O. Ong; Sarah J. Patel; George Potoczniak; Adela G. Sanchez; Charles H. Schrader; Lalit S. Shah; Phil J. Shires; Rae Song

2000-10-26T23:59:59.000Z

187

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The overall objective of this project is the three-phase development of an Early Entrance Coproduction Plant (EECP) that produces at least one product from at least two of the following three categories: Electric power (or heat); Fuels; and Chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or some other carbonaceous feedstock, such as petroleum coke. The objective of Phase I was to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Testing (RD and T) Plan for implementation in Phase II. This objective has now been accomplished. A specific site, Motiva Refinery in Port Arthur, Texas, has been selected as the location best suited for the EECP. The accomplishments of Phase I are discussed in detail in this Phase I Concept Report. A RD and T Plan and a preliminary project financing plan have been developed and are submitted separately from this report.

John S. Abughazaleh; Mushtaq Ahmed; Ashok Anand; John H. Anderson; Charles Benham; Fred D. Brent; Thomas E. Chance; William K. Davis; Raymond F. Drnevich; Larry Hall; Ming He; Stephen A. Lang; David Mintner; Wendy Moore; Jimmy O. Ong; George Potoczniak; Adela G. Sanchez; Charles H. Schrader; Lalit S. Shah; Kalapi D. Sheth; Phil J. Shires; Rae Song

2001-05-17T23:59:59.000Z

188

Training for Early Career Researchers  

E-Print Network [OSTI]

Training for Early Career Researchers Research Management Training for 16 ­ 17 September 2014 training in an intensive, yet effective workshop form over two days. There is a strong emphasis on European Management Training for Early Career Researchers 16 ­ 17 September 2014 in Hamburg #12;

Greifswald, Ernst-Moritz-Arndt-Universität

189

CHERRY: CHECKPOINTED EARLY RESOURCE RECYCLING  

E-Print Network [OSTI]

1 2 3 CHERRY: CHECKPOINTED EARLY RESOURCE RECYCLING Jos´e F. Mart´inez1 , Jose Renau2 Michael C. Huang3 , Milos Prvulovic2 , and Josep Torrellas2 #12;Cherry: Checkpointed Early Resource Recycling efficient use by aggressive recycling Opportunity: Resources reserved until retirement § ¦ ¤ ¥ Solution

Torrellas, Josep

190

AEO2013 Early Release Overview  

Gasoline and Diesel Fuel Update (EIA)

3 Early Release Overview 3 Early Release Overview AEO2013 Early Release Overview Executive summary Projections in the Annual Energy Outlook 2013 (AEO2013) Reference case focus on the factors that shape U.S. energy markets through 2040, under the assumption that current laws and regulations remain generally unchanged throughout the projection period. This early release focuses on the AEO2013 Reference case, which provides the basis for examination and discussion of energy market trends and serves as a starting point for analysis of potential changes in U.S. energy policies, rules, or regulations or potential technology breakthroughs. Readers are encouraged to review the full range of cases that will be presented when the complete AEO2013 is released in early 2013, exploring key uncertainties in the Reference case. Major highlights in the AEO2013 Reference case include:

191

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

As part of the Department of Energy's (DOE) Gasification Technologies and Transportation Fuels and Chemicals programs, DOE and Texaco are partners through Cooperative Agreement DE-FC26-99FT40658 to determine the feasibility of developing, constructing and operating an Early Entrance Coproduction Plant (EECP). The overall objective of the project is the three-phase development of an EECP that produces at least one product from at least two of the following three categories: Electric power (or heat); Fuels; and Chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or some other carbonaceous feedstock, such as petroleum coke. The objective of Phase I was to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Testing (RD and T) Plan for implementation in Phase II. This objective has now been accomplished. A specific site, Motiva Refinery in Port Arthur, Texas, has been selected as the location best suited for the EECP. The specific work requirements of Phase I included: Prepare an EECP Preliminary Concept Report covering Tasks 2-8 specified in the Cooperative Agreement; Develop a Research, Development, and Testing (RD and T) Plan as specified in Task 9 of the Cooperative Agreement for implementation in Phase II; and Develop a Preliminary Project Financing Plan for the EECP Project as specified in Task 10 of the Cooperative Agreement. This document is the Preliminary Project Financing Plan for the design, construction, and operation of the EECP at the Motiva Port Arthur Refinery.

John H. Anderson; William K. Davis; Thomas W. Sloop

2001-03-21T23:59:59.000Z

192

The Age of a Deer.  

E-Print Network [OSTI]

5.7 4153 ---) 8-1453 The Age of a Deer Charles W. Ramsey and Milo J. Shu/t Extension Wildlife Specialists The Texas A&M University System Tooth eruption and wear in deer are closely related to the age of the animal. Deer shed and replace... milk teeth with permanent teeth at con sistent ages. They replace all incisiform milk teeth (front teeth) by 7 months and milk premolars by 19 months. Thus, beyond the fawn stage, a deer's age, unlike the age of sheep, goats, and cattle, cannot...

Ramsey, Charles W.; Shult, Milo J.

1983-01-01T23:59:59.000Z

193

THE EARLY EARLY TYPE: DISCOVERY OF A PASSIVE GALAXY AT z{sub spec} {approx} 3  

SciTech Connect (OSTI)

We present the discovery of a massive, quiescent galaxy at z = 2.99. We have obtained an Hubble Space Telescope WFC3 spectrum of this object and measured its redshift from the detection of a deep 4000 A break consistent with an old population and a high metallicity. By stellar population modeling of both its grism spectrum and broadband photometry, we derive an age of {approx}0.7 Gyr, implying a formation redshift of z > 4, and a mass >10{sup 11} M{sub Sun }. Although this passive galaxy is the most distant confirmed so far, we find that it is slightly less compact than other z > 2 early types of similar mass, being overall more analogous to those z {approx} 1.6 field early-type galaxies. The discovery of this object shows that early-type galaxies are detectable to at least z = 3 and suggests that the diversity of structural properties found in z = 1.4-2 ellipticals to earlier epochs could have its origin in a variety of formation histories among their progenitors.

Gobat, R.; Strazzullo, V.; Daddi, E.; Bethermin, M. [Laboratoire AIM-Paris-Saclay, CEA/DSM-CNRS, Universite Paris Diderot, Irfu/Service d'Astrophysique, CEA Saclay, Orme des Merisiers, F-91191 Gif sur Yvette (France); Onodera, M.; Carollo, M. [Institute for Astronomy, ETH Zuerich Wolfgang-Pauli-strasse 27, CH-8093 Zuerich (Switzerland); Renzini, A. [INAF, Osservatorio Astronomico di Padova Vicolo dell'Osservatorio 5, I-35122 Padova (Italy); Dickinson, M. [National Optical Astronomy Observatory, P.O. Box 26732, Tucson, AZ 85726 (United States); Cimatti, A. [Dipartimento di Astronomia, Universita di Bologna, Via Ranzani 1, I-40127 Bologna (Italy)

2012-11-10T23:59:59.000Z

194

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems was assessed for technical risks and barriers. A plan was developed to mitigate the identified risks (Phase II RD&T Plan, October 2000). The potential technical and economic risks to the EECP from Task 2.5 can be mitigated by demonstrating that the end-use products derived from the upgrading of the F-T synthesis total liquid product can meet or exceed current specifications for the manufacture of ethylene and propylene chemicals from F-T naphtha, for the generation of hydrogen from F-T naphtha to power fuel cells, for direct blending of F-T diesels into transportation fuels, for the conversion of F-T heavy product wax to transportation fuels, and the conversion of F-T Heavy product wax to a valuable high melting point food-grade specialty wax product. Product evaluations conducted under Task 2.5 of Phase II successfully mitigated the above technical and economic risks to the EECP with the development of product yields and product qualities for the production of chemicals, transportation fuels, and specialty food-grade waxes from the F-T synthesis products.

Fred D. Brent; Lalit Shah; Earl Berry; Charles H. Schrader; John Anderson; Ming He; James F. Stevens; Centha A. Davis; Michael Henley; Jerome Mayer; Harry Tsang; Jimell Erwin; Jennifer Adams; Michael Tillman; Chris Taylor; Marjan J. Roos; Robert F. Earhart

2004-01-27T23:59:59.000Z

195

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, Inc., GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. During Phase I, a design basis for the Fischer-Tropsch Synthesis section was developed based on limited experience with the specified feed gas and operating conditions. The objective of this Task in Phase II RD&T work was to confirm the performance of the F-T reactor at the set design conditions. Although much of the research, development, and testing work were done by TES outside of this project, several important issues were addressed in this phase of the project. They included Rejuvenation/Regeneration of the Fischer-Tropsch Catalyst, online Catalyst Withdrawal and Addition from the synthesis reactor, and the Fischer-Tropsch Design Basis Confirmation. In Phase III the results from these RD&T work will be incorporated in developing the engineering design package. This Topical Report documents the Phase II RD&T work that was completed for this task.

David Storm; Govanon Nongbri; Steve Decanio; Ming He; Lalit Shah; Charles Schrader; Earl Berry; Peter Ricci; Belma Demirel; Charles Benham; Mark Bohn

2004-01-12T23:59:59.000Z

196

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

In 1999, the U. S. Department of Energy (DOE) awarded a Cooperative Agreement to Texaco Energy Systems Inc. to provide a preliminary engineering design of an Early Entrance Coproduction Plant (EECP). Since the award, continuous and diligent work has been undertaken to achieve the design of an economical facility that makes strides toward attaining the goal of DOE's Vision 21 Program. The objective of the EECP is to convert coal and/or petroleum coke to power while coproducing transportation fuels, chemicals, and useful utilities such as steam. This objective is being pursued in a three-phase effort through the partnership of the DOE with prime contractor Texaco Energy Systems, LLC. (TES), the successor to Texaco Energy Systems, Inc. The key subcontractors to TES include General Electric (GE), Praxair, and Kellogg Brown and Root. ChevronTexaco provided gasification technology and Rentech Inc.'s Fischer-Tropsch (F-T) technology that has been developed for non-natural gas sources. GE provided gas turbine technology for the combustion of low energy content gas. Praxair provided air separation technology and KBR provided engineering to integrate the facility. A conceptual design was completed in Phase I and the report was accepted by the DOE in May 2001. The Phase I work identified risks and critical research, development, and testing that would improve the probability of technical success of the EECP. The objective of Phase II was to mitigate the risks by executing research, development, and testing. Results from the Phase II work are the subject of this report. As the work of Phase II concluded, it became evident that sufficient, but not necessarily complete, technical information and data would be available to begin Phase III - Preliminary Engineering Design. Work in Phase II requires additional technical development work to correctly apply technology at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The decision to proceed with Phase III centers on locating a new site and favorable commercial and economic factors.

John Anderson; Charles Schrader

2004-01-26T23:59:59.000Z

197

From HIV infection to AIDS: a dynamically induced percolation transition?  

Science Journals Connector (OSTI)

...of viral genomes in genome space usually does not take place. In the case of an HIV...a constant growth rate r(t) = m . 0 does not t the simulation results for viruses...London: Wiley. Gardiner, C. 1983 Handbook of stochastic methods. Berlin: Springer...

2002-01-01T23:59:59.000Z

198

Latent HIV-1 Can Be Reactivated by Cellular Superinfection in a Tat-Dependent Manner, Which Can Lead to the Emergence of Multidrug-Resistant Recombinant Viruses  

Science Journals Connector (OSTI)

...2012. The viral protein Tat can inhibit the establishment of HIV-1 latency. J. Virol. 86...positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic...T cells are enriched for HIV-1 Tat variants with impaired transactivation...

Daniel A. Donahue; Sophie M. Bastarache; Richard D. Sloan; Mark A. Wainberg

2013-06-26T23:59:59.000Z

199

Aging and functional brain networks  

SciTech Connect (OSTI)

Aging is associated with changes in human brain anatomy and function and cognitive decline. Recent studies suggest the aging decline of major functional connectivity hubs in the 'default-mode' network (DMN). Aging effects on other networks, however, are largely unknown. We hypothesized that aging would be associated with a decline of short- and long-range functional connectivity density (FCD) hubs in the DMN. To test this hypothesis, we evaluated resting-state data sets corresponding to 913 healthy subjects from a public magnetic resonance imaging database using functional connectivity density mapping (FCDM), a voxelwise and data-driven approach, together with parallel computing. Aging was associated with pronounced long-range FCD decreases in DMN and dorsal attention network (DAN) and with increases in somatosensory and subcortical networks. Aging effects in these networks were stronger for long-range than for short-range FCD and were also detected at the level of the main functional hubs. Females had higher short- and long-range FCD in DMN and lower FCD in the somatosensory network than males, but the gender by age interaction effects were not significant for any of the networks or hubs. These findings suggest that long-range connections may be more vulnerable to aging effects than short-range connections and that, in addition to the DMN, the DAN is also sensitive to aging effects, which could underlie the deterioration of attention processes that occurs with aging.

Tomasi D.; Tomasi, D.; Volkow, N.D.

2011-07-11T23:59:59.000Z

200

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. During Phase I the team identified several potential methods to reduce or minimize the environmental impact of the proposed EECP. The EECP Project Team identified F-T catalyst disposal, beneficial gasifier slag usage (other than landfill), and carbon dioxide recovery for the gas turbine exhaust for study under this task. Successfully completing the Task 2.10 RD&T provides additional opportunities for the EECP to meet the goals of DOE's Vision 21 Program. The gasification section offers several opportunities to maximize the environmental benefits of an EECP. The spent F-T catalyst can be sent to landfills or to the gasification section. Testing in Phase II shows that the spent F-T catalyst with a small wax coating can safely meet federal landfill requirements. As an alternative to landfilling, it has been proposed to mix the spent F-T catalyst with the petroleum coke and feed this mixture to the gasification unit. Based on ChevronTexaco's experience with gasification and the characteristics of the spent F-T catalyst this appears to be an excellent opportunity to reduce one potential waste stream. The slag from the gasification unit can be commercially marketed for construction or fuel (such as cement kiln fuel) uses. The technical and economic benefits of these options must be reviewed for the final EECP before incorporating a specific alternative into the design basis. Reducing greenhouse gas emissions, particularly carbon dioxide, is an important goal of the EECP. The Texaco gasification process provides opportunities to capture high purity streams of carbon dioxide. For Phase II, a carbon fiber composite molecular sieve (CFCMS) was tested to determine its potential to remove high purity carbon dioxide from the exhaust of a gas turbine. Testing on with a simulated gas turbine exhaust shows that the CFCMS is able to remove high purity carbon dioxide from the exhaust. However, more development is required to optimize the system.

John H. Anderson; Charles Benham; Earl R. Berry; Ming He; Charles H. Schrader; Lalit S. Shah; O.O. Omatete; T.D. Burchell

2004-01-12T23:59:59.000Z

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201

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC (TES), a subsidiary of ChevronTexaco, General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, Inc. GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems were assessed for technical risks and barriers. A plan was identified to mitigate the identified risks (Phase II RD&T Plan, October 2000). The RD&T Plan identified catalyst/wax separation as a potential technical and economic risk. To mitigate risks to the proposed EECP, Phase II RD&T included tests of an alternative (to Rentech's Dynamic Settler) primary catalyst/wax separation device and secondary catalyst/wax separation systems. The team evaluated multiple technologies for both primary and secondary catalyst/wax separation. Based on successful testing at Rentech (outside of DOE funding) and difficulties in finalizing a contract to demonstrate alternative primary catalyst/wax separation technology (using magnetic separation technology), ChevronTexaco has selected the Rentech Dynamic Settler for primary catalyst/wax separation. Testing has shown the Dynamic Settler is capable of producing filtrate exceeding the proposed EECP primary catalyst/wax separation goal of less than 0.1 wt%. The LCI Scepter{reg_sign} Microfiltration system appeared to be best suited for producing a filtrate that met the EECP secondary catalyst/wax separation standards of 10 parts per million (weight) [ppmw]. The other technologies, magnetic separation and electrostatic separation, were promising and able to reduce the solids concentrations in the filtrate. Additional RD&T will be needed for magnetic separation and electrostatic separation technologies to obtain 10 ppmw filtrate required for the proposed EECP. The Phase II testing reduces the technical and economic risks and provides the information necessary to proceed with the development of an engineering design for the EECP Fischer-Tropsch catalyst/wax separation system.

John Anderson; Mark Anselmo; Earl Berry; Mark Bohn; Roko Bujas; Ming He; Ken Kwik; Charles H. Schrader; Lalit Shah; Dennis Slater; Donald Todd; Don Wall

2003-08-21T23:59:59.000Z

202

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to its detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC (TES) (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR). The work was under cooperative agreements with the U.S. Department of Energy (DOE). TES is providing the gasification technology and the Fischer-Tropsch (F-T) technology developed by Rentech Inc., GE is providing the combustion turbine technology, Praxair is providing the air separation technology, and KBR is providing overall engineering. Each of the EECP's subsystems was assessed for technical risks and barriers in Phase I. A plan was identified to mitigate the identified risks (Phase II RD&T Plan, October 2000). The RD&T Plan identified catalyst/wax separation as a potential technical and economic risk. To mitigate risks to the proposed EECP concept, Phase II RD&T included tests for secondary catalyst/wax separation systems as part of Task 2.3--Catalyst/Wax Separation. The LCI Scepter{reg_sign} Microfiltration system was determined to be best suited for producing a filtrate that met the EECP secondary catalyst/wax separation standards of producing F-T wax containing less than10 ppmw solids. As part of task 2.3, micro-filtration removal efficiencies and production rates for two FT feeds, Rentech Inc. bubble column reactor (BCR) product and LaPorte Alternative Fuels Development Unit (AFDU) product, were evaluated. Based on comparisons between the performances of these two materials, the more readily available LaPorte AFDU material was judged an acceptable analog to the BCR material that would be produced in a larger-scale F-T synthesis. The present test was initiated to obtain data in an extended range of concentration for use in the scale-up design of the secondary catalyst/wax separation system that would be operating at the EECP capacity.

John Anderson; Mark Anselmo; Earl Berry; Mark Bohn; Ming He; Charles H. Schrader; Lalit Shah; Donald Todd; Robert Schavey

2004-01-12T23:59:59.000Z

203

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using petroleum coke and ChevronTexaco's proprietary gasification technology. The objective of Phase I was to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC. (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). ChevronTexaco is providing gasification technology and Fischer-Tropsch technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology and KBR is providing engineering. Each of the EECP subsystems were assessed for technical risks and barriers. A plan was identified to mitigate the identified risks (Phase II RD&T Plan, October 2000). The RD&T Plan identified F-T reactor scale-up as a potential technical risk. The objective of Task 2.3 was to confirm engineering models that allow scale-up to commercial slurry phase bubble column (SPBC) reactors operating in the churn-turbulent flow regime. In developmental work outside the scope of this project, historical data, literature references, and a scale-up from a 1 1/2-in. (3.8 cm) to 6-ft (1.8 m) SPBC reactor have been reviewed. This review formed the background for developing scale-up models for a SPBC reactor operating in the churn-turbulent flow regime. The necessary fundamental physical parameters have been measured and incorporated into the mathematical catalyst/kinetic model developed from the SPBC and CSTR work outside the scope of this EECP project. The mathematical catalyst/kinetic model was used to compare to experimental data obtained at Rentech during the EECP Fischer-Tropsch Confirmation Run (Task 2.1; reported separately). The prediction of carbon monoxide (CO) conversion as a function of days on stream compares quite closely to the experimental data.

Randy Roberts

2003-04-25T23:59:59.000Z

204

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. During Phase I the team identified the integration of the water produced in the F-T synthesis section with the gasification section as an area of potential synergy. By utilizing the F-T water in the petroleum coke slurry for the gasifier, the EECP can eliminate a potential waste stream and reduce capital costs. There is a low technical risk for this synergy, however, the economic risk, particularly in regards to the water, can be high. The economic costs include the costs of treating the water to meet the locally applicable environmental standards. This option may require expensive chemicals and treatment facilities. EECP Phase II included tests conducted to confirm the viability of integrating F-T water in the slurry feed for the gasifier. Testing conducted at ChevronTexaco's Montebello Technology Center (MTC) included preparing slurries made using petroleum coke with F-T water collected at the LaPorte Alternative Fuels Development Unit (AFDU). The work included bench scale tests to determine the slurry ability of the petroleum coke and F-T water. The results of the tests show that F-T water does not adversely affect slurries for the gasifier. There are a few cases where in fact the addition of F-T water caused favorable changes in viscosity of the slurries. This RD&T task was executed in Phase II and results are reported herein.

Abdalla H. Ali; Raj Kamarthi; John H. Anderson; Earl R. Berry; Charles H. Schrader; Lalit S. Shah

2003-04-16T23:59:59.000Z

205

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The 1999 U. S. Department of Energy (DOE) award to Texaco Energy Systems Inc. (presently Texaco Energy Systems LLC, a subsidiary of ChevronTexaco) was made to provide a Preliminary Engineering Design of an Early Entrance Coproduction Plant (EECP). Since the award presentation, work has been undertaken to achieve an economical concept design that makes strides toward the DOE Vision 21 goal. The objective of the EECP is to convert coal and/or petroleum coke to electric power plus transportation fuels, chemicals and useful utilities such as steam. The use of petroleum coke was added as a fuel to reduce the cost of feedstock and also to increase the probability of commercial implementation of the EECP concept. This objective has been pursued in a three phase effort through the partnership of the DOE with prime contractor Texaco Energy Systems LLC and subcontractors General Electric (GE), Praxair, and Kellogg Brown and Root (KBR). ChevronTexaco is providing gasification technology and Rentech's Fischer-Tropsch technology that has been developed for non-natural gas feed sources. GE is providing gas turbine technology for the combustion of low energy content gas. Praxair is providing air separation technology, and KBR is providing engineering to integrate the facility. The objective of Phase I was to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. Phase I Preliminary Concept Report was completed in 2000. The Phase I Preliminary Concept Report was prepared based on making assumptions for the basis of design for various technologies that are part of the EECP concept. The Phase I Preliminary Concept Report was approved by the DOE in May 2001. The Phase I work identified technical and economic risks and critical research, development, and testing that would improve the probability of the technical and economic success of the EECP. The Project Management Plan (Task 1) for Phase II was approved by the DOE in 2001. The results of RD&T efforts for Phase II are expected to improve the quality of assumptions made in Phase I for basis of design for the EECP concept. The RD&T work plan (Task 2 and 3) for Phase II has been completed. As the RD&T work conducted during Phase II concluded, it became evident that sufficient, but not necessarily complete, technical information and data would be available to begin Phase III - Basic Engineering Design. Also due to the merger of Chevron and Texaco, the proposed refinery site for the EECP was not available. It became apparent that some additional technical development work would be needed to correctly apply the technology at a specific site. The objective of Task 4 of Phase II is to update the concept basis of design produced during Phase I. As part of this task, items that will require design basis changes and are not site dependent have been identified. The team has qualitatively identified the efforts to incorporate the impacts of changes on EECP concept. The design basis has been modified to incorporate those changes. The design basis changes for those components of EECP that are site and feedstock dependent will be done as part of Phase III, once the site has been selected.

Charles Benham; Mark Bohn; John Anderson; Earl Berry; Fred Brent; Ming He; Randy Roberts; Lalit Shah; Marjan Roos

2003-09-15T23:59:59.000Z

206

AEO2014 Early Release Overview  

U.S. Energy Information Administration (EIA) Indexed Site

Administration | Annual Energy Outlook 2014 Early Release Overview Administration | Annual Energy Outlook 2014 Early Release Overview AEO2014 Early Release Overview Executive summary Projections in the Annual Energy Outlook 2014 (AEO2014) Reference case focus on the factors that shape U.S. energy markets through 2040, under the assumption that current laws and regulations remain generally unchanged throughout the projection period. The early release provides a basis for the examination and discussion of energy market trends and serves as a starting point for analysis of potential changes in U.S. energy policies, rules, or regulations or possible technology breakthroughs. Readers are encouraged to review the full range of cases that will be presented when the complete AEO2014 is released in 2014, exploring key

207

LANL exceeds Early Recovery Act  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

exceeds Early Recovery Act recycling goals March 8, 2010 More than 136 tons of metal saved from demolished buildings LOS ALAMOS, New Mexico, March 9, 2009-Los Alamos National...

208

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems were assessed for technical risks and barriers. A plan was identified to mitigate the identified risks (Phase II RD&T Plan, October 2000). The RD&T Plan identified petroleum coke characteristics as a potential technical risk. The composition of petroleum coke varies from one refinery to another. Petroleum coke characteristics are a function of the crude oil slate available at the refinery and the coker operating parameters. The specific petroleum coke characteristics at a refinery affect the design of the Gasification and Acid Gas Removal (AGR) subsystems. Knowing the petroleum coke composition provides the necessary data to proceed to the EECP Phase III engineering design of the gasification process. Based on ChevronTexaco's experience, the EECP team ranked the technical, economic, and overall risks of the petroleum coke composition related to the gasification subsystem as low. In Phase I of the EECP Project, the Motiva Port Arthur Refinery had been identified as the potential EECP site. As a result of the merger between Texaco and Chevron in October 2001, Texaco was required to sell its interest in the Motiva Enterprises LLC joint venture to Shell Oil Company and Saudi Refining Inc. To assess the possible impact of moving the proposed EECP host site to a ChevronTexaco refinery, samples of petroleum coke from two ChevronTexaco refineries were sent to MTC for bench-scale testing. The results of the analysis of these samples were compared to the Phase I EECP Gasification Design Basis developed for Motiva's Port Arthur Refinery. The analysis confirms that if the proposed EECP is moved to a new refinery site, the Phase I EECP Gasification Design Basis would have to be updated. The lower sulfur content of the two samples from the ChevronTexaco refineries indicates that if one of these sites were selected, the Sulfur Recovery Unit (SRU) might be sized smaller than the current EECP design. This would reduce the capital expense of the SRU. Additionally, both ChevronTexaco samples have a higher hydrogen to carbon monoxide ratio than the Motiva Port Arthur petroleum coke. The higher hydrogen to carbon monoxide ratio could give a slightly higher F-T products yield from the F-T Synthesis Reactor. However, the EECP Gasification Design Basis can not be updated until the site for the proposed EECP site is finalized. Until the site is finalized, the feedstock (petroleum coke) characteristics are a low risk to the EECP project.

Abdalla H. Ali; John H. Anderson; Earl R. Berry; Charles H. Schrader; Lalit S. Shah

2003-04-16T23:59:59.000Z

209

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems was assessed for technical risks and barriers. A plan was developed to mitigate the identified risks (Phase II RD&T Plan, October 2000). Phase II RD&T Task 2.6 identified as potential technical risks to the EECP the fuel/engine performance and emissions of the F-T diesel fuel products. Hydrotreating the neat F-T diesel product reduces potentially reactive olefins, oxygenates, and acids levels and alleviates corrosion and fuel stability concerns. Future coproduction plants can maximize valuable transportation diesel by hydrocracking the F-T Synthesis wax product to diesel and naphtha. The upgraded neat F-T diesel, hydrotreater F-T diesel, and hydrocracker F-T diesel products would be final blending components in transportation diesel fuel. Phase II RD&T Task 2.6 successfully carried out fuel lubricity property testing, fuel response to lubricity additives, and hot-start transient emission tests on a neat F-T diesel product, a hydrocracker F-T diesel product, a blend of hydrotreater and hydrocracker F-T diesel products, and a Tier II California Air Resources Board (CARB)-like diesel reference fuel. Only the neat F-T diesel passed lubricity inspection without additive while the remaining three fuel candidates passed with conventional additive treatment. Hot-start transient emission tests were conducted on the four fuels in accordance with the U.S. Environmental Protection Agency (EPA) Federal Test Procedure (FTP) specified in Code of Federal Regulations, Title 40, Part 86, and Subpart N on a rebuilt 1991 Detroit Diesel Corporation Series 60 heavy-duty diesel engine. Neat F-T diesel fuel reduced oxides of nitrogen (NO{sub x}), total particulate (PM), hydrocarbons (HC), carbon monoxide (CO), and the Soluble Organic Fraction (SOF) by 4.5%, 31%, 50%, 29%, and 35%, respectively, compared to the Tier II CARB-like diesel. The hydrocracker F-T diesel product and a blend of hydrocracker and hydrotreater F-T diesel products also reduced NO{sub x}, PM, HC, CO and SOF by 13%, 16% to 17%, 38% to 63%, 17% to 21% and 21% to 39% compared to the Tier II CARB-like diesel. The fuel/engine performance and emissions of the three F-T diesel fuels exceed the performance of a Tier II CARB-like diesel. Phase II RD&T Task 2.6 successfully met the lubricity property testing and F-T diesel fuel hot-start transient emissions test objectives. The results of the testing help mitigate potential economic risks on obtaining a premium price for the F-T diesel fuel

Fred D. Brent; Lalit Shah; Earl Berry; Charles H. Schrader; John Anderson; J. Erwin; Matthew G. Banks; Terry L. Ullman

2004-01-12T23:59:59.000Z

210

An audit of the standard of care received by HIV positive patients on ART at a community health centre in KZN.  

E-Print Network [OSTI]

??Introduction: South Africa has the highest number of HIV infected individuals in the world.2 The South African government has established National treatment guidelines for HIV… (more)

Inderjeeth, Nishana.

2015-01-01T23:59:59.000Z

211

THE EFFECTS OF HIV INFECTION ON THE EXPRESSION OF THE DRUG EFFLUX PROTEINS P-GLYCOPROTEIN AND BREAST CANCER RESISTANCE PROTEIN IN A HUMAN INTESTINE MODEL  

E-Print Network [OSTI]

Background: Emerging evidence suggests poor antiretroviral penetration within human gastrointestinal (GI) tissues may contribute to HIV persistence within reservoirs despite effective therapy. We hypothesize that HIV ...

Ellis, Kelstan Lynch

2012-08-31T23:59:59.000Z

212

LANL exceeds Early Recovery Act recycling goals  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

LANL exceeds Early Recovery Act recycling goals LANL exceeds Early Recovery Act recycling goals Lab demolition projects under the American Recovery and Reinvestment Act have...

213

Light Water Reactor Sustainability Program: Materials Aging and Degradation  

Broader source: Energy.gov (indexed) [DOE]

Materials Aging and Materials Aging and Degradation Technical Program Plan Light Water Reactor Sustainability Program: Materials Aging and Degradation Technical Program Plan Components serving in a nuclear reactor plant must withstand a very harsh environment including extended time at temperature, neutron irradiation, stress, and/or corrosive media. The many modes of degradation are complex and vary depending on location and material. However, understanding and managing materials degradation is a key for the continued safe and reliable operation of nuclear power plants. Extending reactor service to beyond 60 years will increase the demands on materials and components. Therefore, an early evaluation of the possible effects of extended lifetime is critical. The recent NUREG/CR-6923 gives a

214

Geographic variability in HIV and injection drug use in Ukraine: Implications for integration and expansion of drug treatment and HIV care  

Science Journals Connector (OSTI)

AbstractBackground Ukraine has the highest HIV burden of any European country with much of the current HIV epidemic concentrated among people who inject drugs (PWIDs) and their sexual partners. Opiate substitution therapy (OST) is limited in Ukraine and expansion of OST is urgently needed to help stem the tide of the HIV epidemic. Methods We accessed publicly available data in Ukraine in order to explore geographic variability with respect to prevalence of HIV, \\{PWIDs\\} and OST programmes. Results The regions of Ukraine with the largest number of opioid dependent persons (the south and eastern portions of the country) correspond to the regions with the highest HIV prevalence and HIV incidence. The number of opioid \\{PWIDs\\} per 100,000 population as well as the number of all OST treatment slots per 100,000 varied significantly across the three HIV prevalence categories. Overall, the proportion of individuals receiving either methadone maintenance therapy (MMT) or buprenorphine maintenance therapy (BMT) was quite low: average across categories: 7.3% and 0.4%, respectively. Additionally, less than half of OST patients receiving MMT or BMT were HIV positive patients. Conclusion There is significant geographic variability in both numbers of HIV positive individuals and numbers of \\{PWIDs\\} across Ukraine, however, there may be a more concentrated epidemic among \\{PWIDs\\} in many regions of the country. Scale up of addiction treatment for PWID, especially OST, can have a significant impact on preventing injection related morbidity, such as HIV and HCV infection. Ukraine can learn from the mistakes other nations have made in denying critical treatment opportunities to PWID.

Nickolas Zaller; Alonya Mazhnaya; Sarah Larney; Zahed Islam; Alyona Shost; Tatiana Prokhorova; Natasha Rybak; Timothy Flanigan

2014-01-01T23:59:59.000Z

215

Pathways to neuronal injury and apoptosis in HIV-associated dementia  

Science Journals Connector (OSTI)

... and apoptosis which is blocked by inhibition of the p38 MAP kinase. The NMDAR antagonist memantine prevents neuronal damage in response to HIV/gp120 in cultured neurons as well as in ... to either HIV-infected macrophages or HIV/gp120, both in vitro and in vivo. Memantine, an open-channel blocker, prevents excessive NMDAR activity while sparing physiological function. Also, ...

Marcus Kaul; Gwenn A. Garden; Stuart A. Lipton

2001-04-19T23:59:59.000Z

216

Early Oak Ridge Trailer Homes | Y-12 National Security Complex  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Early Oak Ridge Trailer ... Early Oak Ridge Trailer Homes A row of trailer homes used in early Oak Ridge...

217

A NOVEL TELECOMMUNICATIONS-BASED APPROACH TO MATHEMATICAL MODELING OF HIV INFECTION.  

E-Print Network [OSTI]

??It is well known that biological systems utilize communication in some form, one prolific example of this is the propagation of HIV (Human Immunodeficiency Virus)… (more)

Sharp, Aaron T

2011-01-01T23:59:59.000Z

218

Living with HIV in Egypt : an analysis of needs and caregivers' burden and strain.  

E-Print Network [OSTI]

??As we enter the third decade of a devastating worldwide epidemic, much has been done to stem the flow of HIV/AIDS, in particular within North… (more)

Lashein, Adel.

2008-01-01T23:59:59.000Z

219

Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1  

Science Journals Connector (OSTI)

Femtosecond X-ray crystallography allows structural analysis of a difficult-to-crystallize fusion protein that is a potential component of a candidate HIV-1 subunit vaccine.

Lee, H.-H.

2014-08-20T23:59:59.000Z

220

Proteomic Analysis of Saliva in HIV-positive Heroin Addicts Reveals Proteins Correlated with Cognition  

SciTech Connect (OSTI)

The prevalence of HIV-associated neurocognitive disorders (HAND) remains high despite effective antiretroviral therapies. Multiple etiologies have been proposed over the last few years to account for this phenomenon, including the neurotoxic effects of antiretrovirals and co-morbid substance abuse. However, no underlying molecular mechanism has been identified. Emerging evidence in several fields has linked the gut to brain diseases, but the effect of the gut on the brain during HIV infection has not been explored. Saliva is the most accessible gut biofluid, and is therefore of great scientific interest for diagnostic and prognostic purposes. This study presents a longitudinal, liquid chromatography-mass spectrometry-based quantitative proteomics study investigating saliva samples taken from 8 HIV-positive (HIV+) and 11 -negative (HIV-) heroin addicts. In the HIV+ group, 58 proteins were identified that show significant correlations with cognitive scores and that implicate disruption of protein quality control pathways by HIV. Notably, no proteins from the HIV- heroin addict cohort showed significant correlations with cognitive scores. In addition, the majority of correlated proteins have been shown to be associated with exosomes, allowing us to propose that the salivary glands and/or oral epithelium may modulate brain function during HIV infection through the release of discrete packets of proteins in the form of exosomes.

Dominy, Stephen; Brown, Joseph N.; Ryder, Mark I.; Gritsenko, Marina A.; Jacobs, Jon M.; Smith, Richard D.

2014-04-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

E-Print Network 3.0 - antenatal hiv testing Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

testing Search Powered by Explorit Topic List Advanced Search Sample search results for: antenatal hiv testing Page: << < 1 2 3 4 5 > >> 1 AIDS . Author manuscript Infant feeding,...

222

E-Print Network 3.0 - advanced hiv-1 infection Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

A double-blind, randomized trial of a recombinant HIV-1... not prevent ... Source: Gilbert, Peter - Fred Hutchinson Cancer Research Center & Department of Biostatistics,...

223

E-Print Network 3.0 - aids-free hiv-1-infected patients Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

recombinant HIV-1... of these studies designed to evaluate whether an rgp120 ... Source: Gilbert, Peter - Fred Hutchinson Cancer Research Center & Department of Biostatistics,...

224

E-Print Network 3.0 - assay chembio hiv Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

In... 654 JID 2005:191 (1 March) rgp120 HIV Vaccine Study Group M A ... Source: Gilbert, Peter - Fred Hutchinson Cancer Research Center & Department of Biostatistics,...

225

POSITIVE AND NEGATIVE REGULATION OF HIV REPLICATION IN MACROPHAGES: ROLE OF RON RECEPTOR TYROSINE KINASE.  

E-Print Network [OSTI]

??Although the hallmark of acquired immunodeficiency syndrome (AIDS) is the depletion of CD4+ T cells, macrophages play an important role during HIV-1 infection and progression… (more)

Kalantari, Parisa

2007-01-01T23:59:59.000Z

226

Tat-regulated expression of RNA interference: Triggers for the treatment of HIV infection  

Science Journals Connector (OSTI)

HIV infection is a lifelong problem requiring continual medication for suppressing viral replication. Current strategies of antiretroviral drug combinations have proven effective in prolonging the time from in...

Hoshang Unwalla; John J. Rossi

2008-02-01T23:59:59.000Z

227

Function and regulation of the Super Elongation Complexes in HIV-1 transcription.  

E-Print Network [OSTI]

??In 2010, we discovered that the HIV-1 transactivator Tat interacts with a set of related transcription complexes containing two different classes of general transcription elongation… (more)

Hsu, Joanne H.

2012-01-01T23:59:59.000Z

228

E-Print Network 3.0 - abbott realtime hiv-1 Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Summary: .06.006 Stochastic Gene Expression in a Lentiviral Positive-Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic... that the phage's lysislysogeny life-cycle...

229

The apoptotic potential of different HIV-1 subtype C Tat mutations in cell culture.  

E-Print Network [OSTI]

??The efficiency in which HIV-1 can infect, spread and evade the attack of therapeutic agents can be attributed to a high mutation rate and frequent… (more)

Isaacs, Shahieda

2013-01-01T23:59:59.000Z

230

E-Print Network 3.0 - alkenyldiarylmethane adam hiv-1 Sample...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

human WRN WS fibroblasts, lacking a functional wrn... gene, are impaired for basal and Tat-activated HIV-1 ... Source: Monnat, Ray - Department of Genome Sciences, University of...

231

Modeling within-host HIV-1 dynamics and the evolution of drug ...  

E-Print Network [OSTI]

Apr 19, 2007 ... Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet 354, 1782–1785. Ribeiro ...

2007-07-25T23:59:59.000Z

232

Script generation and multitasking in HIV-1 infection : implications for everyday functioning  

E-Print Network [OSTI]

Gagnon S. (2004). Script generation following frontal andGroup. (2005). Action (verb) generation in HIV-1 infection.Note. SG = Script Generation test; MT = Multitasking test. *

Scott, James Cobb

2009-01-01T23:59:59.000Z

233

Compare Activities by Building Age  

U.S. Energy Information Administration (EIA) Indexed Site

Activities by Building Age Activities by Building Age Compare Activities by ... Building Age Median Age of Building by Building Type Vacant buildings, retail stores (other than malls), and religious worship buildings tended to be the oldest buildings. Food sales buildings (which were predominantly convenience stores) and outpatient health care buildings were mainly newer buildings. Figure showing median age of building by building type. If you need assistance viewing this page, please call 202-586-8800. Specific questions may be directed to: Joelle Michaels joelle.michaels@eia.doe.gov CBECS Manager Release date: July 24, 2002 Page last modified: May 4, 2009 2:52 PM http://www.eia.gov/consumption/commercial/data/archive/cbecs/pba99/compareage.html If you are having any technical problems with this site, please contact the EIA

234

Inhibition of human immunodeficiency virus type-1 (HIV-1) glycoprotein-mediated cell-cell fusion by immunor (IM28)  

Science Journals Connector (OSTI)

Immunor (IM28), an analog of dehydroepiandrosterone (DHEA), inhibits human immunodeficiency virus type-1 (HIV-1) by inhibiting reverse ... ability of IM28 to inhibit the cell-cell fusion mediated by HIV envelope ...

Donatien Mavoungou; Virginie Poaty-Mavoungou; Marie-Yvonne Akoume…

2005-02-01T23:59:59.000Z

235

Cost Analysis of an HIV/AIDS Prevention Project: A Case Study of the AIDS 3 Project in BENIN.  

E-Print Network [OSTI]

??HIV/AIDS Cost analysis The objective of this thesis is to undertake a cost analysis of an HIV/AIDS prevention programme targeting vulnerable groups in Benin. The… (more)

Mito-Yobo, Kodjo Ferdinand

2011-01-01T23:59:59.000Z

236

HIV Stigma, Testing Attitudes and Health Care Access Among African-Born Men Living in the United States  

Science Journals Connector (OSTI)

The purpose of this study was to describe HIV-testing attitudes, HIV related stigma and health care access in African-born men taking part in the African Health Cup (AHC), a soccer tournament held annually to ...

Carol Bova; Chioma Nnaji; Augustus Woyah…

2014-11-01T23:59:59.000Z

237

Stigma trajectories among people living with HIV (PLHIV) embarking on a life time journey with antiretroviral drugs in Jinja, Uganda  

E-Print Network [OSTI]

therapy in Jinja, Uganda. Cult Health Sexuality 2011, 13(5):of HIV and AIDS in Rakai, Uganda. 1975–1990. Afr J AIDS Restested HIV negative in Uganda. Sociol Health Illn 2011, 36.

Mbonye, Martin; Nakamanya, Sarah; Birungi, Josephine; King, Rachel; Seeley, Janet; Jaffar, Shabbar

2013-01-01T23:59:59.000Z

238

CANNABINOID MODULATION OF HIV-1 TAT-STIMULATED ADHESION OF MACROPHAGE-LIKE CELLS TO THE EXTRACELLULAR MATRIX.  

E-Print Network [OSTI]

??HIV-Associated Neurocognitive Disorders (HANDs) are becoming one of the largest problems in patients infected with HIV-1. The ability of infected cells such as monocytes and… (more)

Drevik, Johnathan

2013-01-01T23:59:59.000Z

239

Small variations in multiple parameters account for wide variations in HIV–1 set–points: a novel modelling approach  

Science Journals Connector (OSTI)

...Theoretical Biology, Utrecht University, Padualaan, , 8, 3584 CH Utrecht, The Netherlands Steady-state...mathematical model. Here we applied the approach to HIV-1...mathematical model. Here we applied the approach to HIV-1...Theoretical Biology, Utrecht University, Padualaan...

2001-01-01T23:59:59.000Z

240

Interactions between Lipids and Human Anti-HIV Antibody 4E10 Can Be Reduced without Ablating Neutralizing Activity  

Science Journals Connector (OSTI)

...either air or nitrogen gas. The immersion depth...mutant Fv4E10 binding drives conformational changes...NAb responses during natural infection (3, 19...antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine...

Hengyu Xu; Likai Song; Mikyung Kim; Margaret A. Holmes; Zane Kraft; George Sellhorn; Ellis L. Reinherz; Leonidas Stamatatos; Roland K. Strong

2009-11-11T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

AGING SYSTEM DESIGN DEVELOPMENT STRATEGY  

SciTech Connect (OSTI)

This plan provides an overview, work to date, and the path forward for the design development strategy of the Aging cask for aging commercial spent nuclear fuel (CSNF) at the Yucca Mountain Project (YMP) repository site. Waste for subsurface emplacement at the repository includes US Department of Energy (DOE) high-level radioactive waste (HLW), DOE SNF, commercial fuel in dual-purpose canisters (DPCs), uncanistered bare fuel, naval fuel, and other waste types. Table 1-1 lists the types of radioactive materials that may be aged at YMP, and those materials that will not be placed in an aging cask or module. This plan presents the strategy for design development of the Aging system. The Aging system will not handle naval fuel, DOE HLW, MCOs, or DOE SNF since those materials will be delivered to the repository in a state and sequence that allows them to be placed into waste packages for emplacement. Some CSNF from nuclear reactors, especially CSNF that is thermally too hot for emplacement underground, will need to be aged at the repository.

J. Beesley

2005-02-07T23:59:59.000Z

242

The Exponential Phase of HIV/AIDS Epidemic in Japan  

E-Print Network [OSTI]

The Exponential Phase of HIV/AIDS Epidemic in Japan Hisashi INABA Institute of Population Problems 2-2, 1-Chome, Kasumigaseki, Chiyoda-ku Tokyo 100-45, Japan F--K"$K$*$1$k#H#I#V!?#A#I#D#S$N;X?t4X incidence in Japan has been growing exponentially. Using our calculation method, we conclude that the number

Inaba, Hisashi

243

The Werner Syndrome Helicase Is a Cofactor for HIV-1 Long Terminal Repeat Transactivation and Retroviral Replication*  

E-Print Network [OSTI]

gene, are impaired for basal and Tat-activated HIV-1 transcription. Overexpression of wild-type WRN transactivates the HIV-1 long terminal repeat (LTR) in the absence of Tat, and WRN cooperates with Tat to promoteThe Werner Syndrome Helicase Is a Cofactor for HIV-1 Long Terminal Repeat Transactivation

Monnat, Ray

244

Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin Derivative, BPRHIV001, through the Akt Pathway  

Science Journals Connector (OSTI)

...and Antiviral Agents Inhibition of HIV-1 Tat-Mediated Transcription by a Coumarin...Fig. 1. Effects of BPRHIV001 on HIV-1 Tat-mediated transactivation. (A...effects were found to be mediated by HIV-1 Tat (14). Tat was shown to mediate...

Pi-Han Lin; Yi-Yu Ke; Chun-Ting Su; Hui-Yi Shiao; Hsing-Pang Hsieh; Yu-Kai Chao; Chun-Nan Lee; Chuan-Liang Kao; Yu-Sheng Chao; Sui-Yuan Chang

2011-06-22T23:59:59.000Z

245

Cell Senescence: Aging and Cancer  

ScienceCinema (OSTI)

Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals.

Campisi, Judith

2013-05-29T23:59:59.000Z

246

Peak of the Oil Age  

Science Journals Connector (OSTI)

In late October 2003 The Economist published an article titled, “The End of the Oil Age” [1]. In the article’s introduction reference was made to a statement by Sheikh Yamani who served as Saudi Arabia’s minister...

Kjell Aleklett

2012-01-01T23:59:59.000Z

247

Source identification in two criminal cases using phylogenetic analysis of HIV-1 DNA sequences  

Science Journals Connector (OSTI)

...is to improve health and contribute to political stability and economic prosperity within the region...any activity that would put others at risk for HIV infection, including but not...for HIV in 1997 when qualifying for life insurance. Since 2002, she reported only having...

Diane I. Scaduto; Jeremy M. Brown; Wade C. Haaland; Derrick J. Zwickl; David M. Hillis; Michael L. Metzker

2010-01-01T23:59:59.000Z

248

HIV and Its Treatment Is My Treatment Regimen Working? Is My Treatment Regimen Working?  

E-Print Network [OSTI]

viral load, it's important to closely follow your treatment regimen. Poor treatment adherence can also blood tests to monitor your HIV treatment: CD4 count and viral load test. The results of the tests need a CD4 count only once every 6 to 12 months. What is a viral load test? Preventing HIV from

Levin, Judith G.

249

Design opportunities for supporting treatment of people living with HIV / AIDS in India  

Science Journals Connector (OSTI)

We describe a qualitative user study that we conducted with 64 people living with HIV/AIDS (PLHA) in India recruited from private sector clinics. Our aim was to investigate information gaps, problems, and opportunities for design of relevant technology ... Keywords: HIV/AIDS, adherence, design for development, healthcare, user study

Anirudha Joshi; Mandar Rane; Debjani Roy; Shweta Sali; Neha Bharshankar; N. Kumarasamy; Sanjay Pujari; Davidson Solomon; H. Diamond Sharma; D. G. Saple; Romain Rutten; Aakash Ganju; Joris Van Dam

2011-09-01T23:59:59.000Z

250

Feasibility and Reproducibility of HIV-1 Genotype Resistance Test in Very-Low-Level Viremia  

Science Journals Connector (OSTI)

...Feasibility and Reproducibility of HIV-1 Genotype Resistance Test in Very-Low-Level Viremia Bianca Bruzzone a Antonio Di Biagio...Reliability and clinical relevance of the HIV-1 drug resistance test in patients with low viremia levels. Clin. Infect. Dis. 58...

Bianca Bruzzone; Antonio Di Biagio; Laura Sticchi; Renata Barresi; Francesco Saladini; Giancarlo Icardi; Maurizio Setti

2014-12-01T23:59:59.000Z

251

Control of Stochastic Gene Expression by Host Factors at the HIV Promoter  

E-Print Network [OSTI]

Control of Stochastic Gene Expression by Host Factors at the HIV Promoter John C. Burnett1 Berkeley National Laboratory, Berkeley, California, United States of America Abstract The HIV promoter by the Tat positive feedback loop can contribute to the formation of either a productive, transactivated

Schaffer, David V.

252

DDX3 RNA helicase is required for HIV-1 Tat function  

Science Journals Connector (OSTI)

Abstract Host RNA helicase has been involved in human immunodeficiency virus type 1 (HIV-1) replication, since HIV-1 does not encode an RNA helicase. Indeed, DDX1 and DDX3 DEAD-box RNA helicases are known to be required for efficient HIV-1 Rev-dependent RNA export. However, it remains unclear whether DDX RNA helicases modulate the HIV-1 Tat function. In this study, we demonstrate, for the first time, that DDX3 is required for the HIV-1 Tat function. Notably, DDX3 colocalized and interacted with HIV-1 Tat in cytoplasmic foci. Indeed, DDX3 localized in the cytoplasmic foci P-bodies or stress granules under stress condition after the treatment with arsenite. Importantly, only DDX3 enhanced the Tat function, while various distinct DEAD-box RNA helicases including DDX1, DDX3, DDX5, DDX17, DDX21, and DDX56, stimulated the HIV-1 Rev-dependent RNA export function, indicating a specific role of DDX3 in Tat function. Indeed, the ATPase-dependent RNA helicase activity of DDX3 seemed to be required for the Tat function as well as the colocalization with Tat. Furthermore, the combination of DDX3 with other distinct DDX RNA helicases cooperated to stimulate the Rev but not Tat function. Thus, DDX3 seems to interact with the HIV-1 Tat and facilitate the Tat function.

Mariko Yasuda-Inoue; Misao Kuroki; Yasuo Ariumi

2013-01-01T23:59:59.000Z

253

Transmission of HIV-1 minority resistant variants and response to first-line antiretroviral therapy  

E-Print Network [OSTI]

1 Transmission of HIV-1 minority resistant variants and response to first-line antiretroviral: Transmission of minority resistant HIV-1 1 Table, 2 Figures Text : 3483 words Abstract : 250 words Presented 2008;22(12):1417-23" DOI : 10.1097/QAD.0b013e3283034953 #12;2 Abstract Background: The transmission

Paris-Sud XI, Université de

254

Closer to HIV vaccine goal with new insight into viral factors  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Closer to HIV vaccine goal with new insight into viral factors Closer to HIV vaccine goal with new insight into viral factors New insight into viral factors that facilitate HIV transmission Understanding viral factors that facilitate transmission of HIV infection is critical to developing vaccines. February 14, 2012 Scientists work at the National Stable Isotope Resource LANL scientists found that the infected donor's predominant virus subpopulation in the genital tract differed from that in the blood. Comparing the HIV sequence population in each newly infected partner with that in the genital tract of the transmitting partner revealed that the transmitted variant was genetically distinct from the donor's predominant genital-tract variants. The results imply that a selective process, rather than a random one, determines the transmitted or founder virus.

255

THE AGE OF PLASTIC INGENUITY + RESPONSIBILITY  

E-Print Network [OSTI]

THE AGE OF PLASTIC INGENUITY + RESPONSIBILITY An Interdisciplinary Symposium Stone Age, Bronze Age, Iron Age...and now the Age of Plastic. The Smithsonian Institution is leveraging its collections--arguably the world's greatest repository of plastic material culture--to investigate the significance of plastic, its

Mathis, Wayne N.

256

MAGNETOSTRATIGRAPHY OF THE EARLY CRETACEOUS WEALDEN GROUP, ISLE OF WIGHT Conall Mac Niocaill, & Stephen Hesselbo  

E-Print Network [OSTI]

available database. The goal of this project is to obtain high-precision estimates of the intensity wetlands and have recently yielded important data on Early Cretaceous atmospheric carbon dioxide content and carbon-isotopic composition. Being non-marine, however, the age of the succession is imprecisely known

Niocaill, Conall Mac

257

Cumulative strategic capability and performance of early movers and followers in the cyber market  

Science Journals Connector (OSTI)

Today, the cyber market is evolving rapidly in the networked age. In the cyber market, the traditional competitive strategy appears to no longer be effective. This study investigates the strategic choice differences of online firms based on their strategic ... Keywords: Cyber market, Early mover, Follower, Porter's generic strategies, Sand Cone model

Sang-Gun Lee; Chulmo Koo; Kichan Nam

2010-06-01T23:59:59.000Z

258

Detrital geochronology and geochemistry of CretaceousEarly Miocene strata of Nepal: implications for timing and  

E-Print Network [OSTI]

Detrital geochronology and geochemistry of Cretaceous­Early Miocene strata of Nepal: implications of the southern Lesser Himalayan zone of central Nepal. The Cretaceous­ Paleocene(?) Amile Formation is dominated documented by the U­Pb zircon ages. The fact that middle Eocene strata in Nepal were derived from

Najman, Yani

259

HIV-1 Group O Integrase Displays Lower Enzymatic Efficiency and Higher Susceptibility to Raltegravir than HIV-1 Group M Subtype B Integrase  

Science Journals Connector (OSTI)

...J Sievers, and JM Yeo. 2013. Integrase genotypic and phenotypic predictors of antiviral response to integrase inhibitors (INIs). Antivir. Ther. 18 :A37. 25. Prada, N , and M Markowitz. 2010. Novel integrase inhibitors for HIV. Expert Opin...

Agnčs Depatureaux; Peter K. Quashie; Thibault Mesplčde; Yingshan Han; Hannah Koubi; Jean-Christophe Plantier; Maureen Oliveira; Daniela Moisi; Bluma Brenner; Mark A. Wainberg

2014-09-15T23:59:59.000Z

260

Elucidation of the mechanism involved in long-term survival of HIV-1 infected macrophages: A new strategy targeting HIV reservoirs.  

E-Print Network [OSTI]

??The interaction of Human Immunodeficiency Virus Type 1 (HIV-1) with target CD4+ T lymphocytes is well-studied and typically leads to virally-induced cytolysis, resulting in the… (more)

Chugh, Pauline E.

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

Identification of a potential HIV-induced source of bystander-mediated apoptosis in T cells: Upregulation of TRAIL in primary human macrophages by HIV-1 tat  

Science Journals Connector (OSTI)

The induction of apoptosis in T cells by bystander cells has been repeatedly implicated as a mechanism contributing to the T cell depletion seen in HIV infection. It has been shown that apoptosis ... could be ind...

Mingjie Zhang; Xingxiang Li; Xiaowu Pang; Linna Ding…

262

Mechanisms of Mating-Behavior Deterioration in Early Aging Male C. elegans  

E-Print Network [OSTI]

into their hermaphrodite mates. Through Ca^(2+) imaging, I found that the genital sex muscles are hyper-contracted during sperm transfer. This hyper-contraction blocks the vas deferens and obstructs sperm release. Furthermore, through qPCR, measurements of metabolites...

Guo, Xiaoyan

2014-08-06T23:59:59.000Z

263

Early Tertiary Age of Pitchstone in the Northern Black Hills, South Dakota  

Science Journals Connector (OSTI)

...the glass is isotropic but has tiny anisotropic particles. Some of these particles are...offossil-iferous Upper Cretaceous Carlile shale. The Carlile is about 1100 m stratigraphi-cally...xiii). Drake supposed that the Carlile shale fragments had been acquired from steep...

JACK A. REDDEN; JOHN D. OBRADOVICH; CHARLES W. NAESER; ROBERT E. ZARTMAN; JAMES J. NORTON

1983-06-10T23:59:59.000Z

264

Early agriculture and crop transmission among Bronze Age mobile pastoralists of Central Eurasia  

Science Journals Connector (OSTI)

...middle second millennium BC, seasonal camps in the mountains and deserts illustrate...lifeways and settled farming has shaped centuries of history and prehistoric research in...pastoralists clearly had access to grains centuries earlier, our data show that mobile herders...

2014-01-01T23:59:59.000Z

265

Defining "Foreignness" in the Early Iron Age Mediterranean Program (subject to revision)  

E-Print Network [OSTI]

, and Administrator and Editor, Melammu Project Website and Database 2:40 Persis Berlekamp, Department of Art History Department of Art History and Humanities Institute, Northwestern University 9:35 Catherine Saint of Tartessos #12;12:15-2:00 Lunch 2:00 Johannes Haubold, Classics and Ancient History, Durham University 2

Shahriar, Selim

266

Modeling the Effect of Curing on Early Age Distress Potential of Concrete Pavement  

E-Print Network [OSTI]

in concrete structure. The results indicated that the constructability index was able to capture and demonstrate the effect of different parameters mentioned above on the constructability of rigid pavement/overlay projects....

Bari, Muhammad Ehsanul

2014-04-11T23:59:59.000Z

267

‘Fire Burn and Cauldron Bubble’: Iron Age and Early Roman Cauldrons of Britain and Ireland  

E-Print Network [OSTI]

and Belgium (Stead & Rigby 1986, 59). Moss-Eccardt draws attention to the work of Eggers (1951, Tafel 2, Karte 10-11) who illustrates a number of different variants of cauldron which are very similar in form, particularly Eggers’ Type 5...

Joy, Jody

2014-10-28T23:59:59.000Z

268

Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female Aging and  

E-Print Network [OSTI]

in parallel to the decline in glucose transport suggesting lactate did not serve as an alternative fuel as an alternative fuel. In the 3xTgAD brain, utilization of ketone bodies as an alternative fuel was evident in mitochondrial function. The adaptive shift to the ketogenic system as an alternative fuel coincided with decline

Brinton, Roberta Diaz

269

Concrete Plant International (2008) REACT: Reducing Early-Age Cracking Today  

E-Print Network [OSTI]

construction. As is usually the case, the truth likely lies between these two extremes, perhaps humidity, wind speed, and concrete temperature to the evaporation rate from a water surface. Recently

Bentz, Dale P.

270

Inhibition of HIV-1 tat-induced transactivation and apoptosis by the divalent metal chelators, fusaric acid and picolinic acid—Implications for HIV-1 dementia  

Science Journals Connector (OSTI)

The HIV-1 transactivator protein tat is pivotal to the pathogenesis of AIDS, exerting its effects on both viral and cellular gene expression. The basic structure of tat protein allows it to be secreted by HIV-1 infected cells and penetrate uninfected cells where it elicits its multifunctional biochemical effects. The main function of tat protein is viral transactivation which leads to the upregulation of transcription through complex interactions with RNA and host cell factors. Since HIV-1 has been widely implicated as a causative agent of HIV-1 dementia, the aim of our study was to investigate the ability of two novel metal chelators, fusaric acid (FA) and picolinic acid (PA) to firstly inhibit HIV-1 tat induced transcription and secondly, to minimize its cytotoxic effects as mediated via apoptosis. Biologically active tat protein is not freely available commercially. We therefore had to produce, isolate and purify our own protein. A cell culture system and flow cytometric techniques were used in our study. Exposure of CEM-GFP cells to exogenous recombinant tat protein induced transcription and apoptosis, and both processes were inhibited by FA and PA at concentrations that alone did not induce any cytotoxicity. Our data suggest that FA and PA may have therapeutic potential in the management of HIV-1 dementia.

Atish Ramautar; Musa Mabandla; Jonathan Blackburn; Willie M.U. Daniels

2012-01-01T23:59:59.000Z

271

For Early Adopters | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

For Early Adopters For Early Adopters Many people consider hydrogen and fuel cells to be longer-term technologies, but they're beginning to enter the market now in certain...

272

Deactivation of Accelerated Engine-Aged and Field-Aged SCR Catalysts...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

of Accelerated Engine-Aged and Field-Aged SCR Catalysts and the Role of the DOC Deactivation of Accelerated Engine-Aged and Field-Aged SCR Catalysts and the Role of the DOC A...

273

Non-uniform Aging on Super Duty Diesel Truck Aged Urea Cu/Zeolite...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

uniform Aging on Super Duty Diesel Truck Aged Urea CuZeolite SCR Catalysts Non-uniform Aging on Super Duty Diesel Truck Aged Urea CuZeolite SCR Catalysts CuZeolite SCR catalysts...

274

Accelerated Aging of Roofing Surfaces  

Broader source: Energy.gov (indexed) [DOE]

Accelerated aging of roofing surfaces Accelerated aging of roofing surfaces Hugo Destaillats, Ph.D. Lawrence Berkeley National Laboratory HDestaillats@LBL.gov (510) 486-5897 http://HeatIsland.LBL.gov April 4, 2013 Development of Advanced Building Envelope Surface Materials & Integration of Artificial Soiling and Weathering in a Commercial Weatherometer New York Times, 30 July 2009 2010 2012 Challenge: speed the development of high performance building envelope materials that resist soiling, maintain high solar reflectance, and save energy 2 | Building Technologies Office eere.energy.gov

275

Equal Access Initiative HIV/AIDS Information Resources from NLM  

SciTech Connect (OSTI)

The Equal Access Initiative: HIV/AIDS Information Resources from the National Library of Medicine training is designed specifically for the National Minority AIDS Council 2010 Equal Access Initiative (EAI) Computer Grants Program awardees to provide valuable health information resources from the National Library of Medicine and other reliable sources to increase awareness of the wealth of treatment information and educational materials that are available on the Internet and to improve prevention and treatment education for their clients. These resources will also meet the needs of community-based

Templin-Branner W. and N. Dancy

2010-09-11T23:59:59.000Z

276

Single-Pill Regimens for HIV-1 Infection  

Science Journals Connector (OSTI)

...efavirenz, tenofovir, and emtricitabine (EFV–TDF–FTC; Atripla, Bristol-Myers Squibb and Gilead Sciences) would not preclude the future use of rilpivirine with TDF–FTC (Complera, Gilead Sciences). However, the reverse is not the case, given the Y181C mutation that commonly occurs with exposure... To the Editor: With regard to the choice of a single-tablet combination regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection, an important consideration that is not highlighted in the article by Gandhi and Gandhi (July 17 ...

2014-11-06T23:59:59.000Z

277

Aging, tumor suppression and cancer: High-wire act!  

SciTech Connect (OSTI)

Evolutionary theory holds that aging is a consequence of the declining force of natural selection with age. We discuss here the evidence that among the causes of aging in complex multicellular organisms, such as mammals, is the antagonistically pleiotropic effects of the cellular responses that protect the organism from cancer. Cancer is relatively rare in young mammals, owing in large measure to the activity of tumor suppressor mechanisms. These mechanisms either protect the genome from damage and/or mutations, or they elicit cellular responses--apoptosis or senescence--that eliminate or prevent the proliferation of somatic cells at risk for neoplastic transformation.We focus here on the senescence response, reviewing its causes, regulation and effects. In addition, we describe recent data that support the idea that both senescence and apoptosis may indeed be the double-edged swords predicted by the evolutionary hypothesis of antagonistic pleiotropy--protecting organisms from cancer early in life, but promoting aging phenotypes, including late life cancer, in older organisms.

Campisi, Judith

2004-08-15T23:59:59.000Z

278

The new biology of ageing  

Science Journals Connector (OSTI)

...clear, potential message for the medical...that evolutionary conservation of the mechanisms...2007 Evolutionary conservation of regulated longevity...Mechanisms of ageing: public or private? Nat...immunity and lifetime energy intake. J. Nutr...improvements in public health and lifestyle...

2010-01-01T23:59:59.000Z

279

Connecticut 4-H Name: __________________Age:____  

E-Print Network [OSTI]

Connecticut 4-H Name: __________________Age:____ County: _________________________ #12;In, University of Connecticut, Storrs. Issued in furtherance of Cooperative Extension Work, Acts of May 8 The Connecticut 4-H Smart Shopper Workbook contains adaptations of 4-H materials from Iowa, Kentucky, and the New

Holsinger, Kent

280

A Design Guide for Early-Market Electrochromic Windows  

E-Print Network [OSTI]

Guide for Early-Market Electrochromic Windows. CaliforniaGuide for Early-Market Electrochromic Windows. CaliforniaGUIDE FOR EARLY-MARKET ELECTROCHROMIC WINDOWS Prepared For:

2006-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

White House honors Los Alamos physicist's early career work  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

White House honors physicist's early career work White House honors Los Alamos physicist's early career work Ivan Vitev has received a prestigious Presidential Early Career Award...

282

Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men  

Science Journals Connector (OSTI)

...medical history. Chemical and hematologic analyses were performed at weeks 4, 8, 12, 16, and 24 and every 12 weeks thereafter. During screening, a computer-assisted structured interview collected information about education level, self-identified sex, and alcohol use, along with subjects' perceived study... In this study, 2499 HIV-seronegative men or transgender women who were at high risk for HIV acquisition were enrolled in a trial of daily emtricitabine plus tenofovir versus placebo. Those receiving the antiretroviral medication had a 44% reduction in HIV incidence.

Grant R.M.; Lama J.R.; Anderson P.L.

2010-12-30T23:59:59.000Z

283

AEO2010 Early Release Overview  

Gasoline and Diesel Fuel Update (EIA)

10 10 Early Release Overview December 2009 Energy Trends to 2035 In preparing the Annual Energy Outlook 2010 (AEO- 2010), the Energy Information Administration (EIA) evaluated a wide range of trends and issues that could have major implications for U.S. energy markets. This overview focuses primarily on one case, the AEO2010 reference case, which is presented and com- pared with the updated Annual Energy Outlook 2009 (updated AEO2009) reference case released in April 2009 1 (see Table 1). Because of the uncertainties in- herent in any energy market projection, particularly in periods of high price volatility, rapid market trans- formation, or active changes in legislation, the refer- ence case results should not be viewed in isolation. Readers are encouraged to review the alternative cases when the complete AEO2010 publication is re- leased in order to gain perspective on how variations

284

E-Print Network 3.0 - apobec3g drives hiv-1 Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Adaptive Evolution of the Primate Antiviral DNA-Editing Summary: , Schrofelbauer B, Navarro F, Konig R, et al. (2003) Species- specific exclusion of APOBEC3G from HIV-1...

285

E-Print Network 3.0 - acquired paediatric hiv Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

1 Summary: for one third to 40% of perinatally acquired HIV infections 2 . The overall risk of postnatal transmission... , Ekpini R, et al. Breast-feeding and Transmission of...

286

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01  

SciTech Connect (OSTI)

During HIV-1 infection, antibodies are generated against the region of the viral gp120 envelope glycoprotein that binds CD4, the primary receptor for HIV-1. Among these antibodies, VRC01 achieves broad neutralization of diverse viral strains. We determined the crystal structure of VRC01 in complex with a human immunodeficiency virus HIV-1 gp120 core. VRC01 partially mimics CD4 interaction with gp120. A shift from the CD4-defined orientation, however, focuses VRC01 onto the vulnerable site of initial CD4 attachment, allowing it to overcome the glycan and conformational masking that diminishes the neutralization potency of most CD4-binding-site antibodies. To achieve this recognition, VRC01 contacts gp120 mainly through immunoglobulin V-gene regions substantially altered from their genomic precursors. Partial receptor mimicry and extensive affinity maturation thus facilitate neutralization of HIV-1 by natural human antibodies.

Zhou, Tongqing; Georgiev, Ivelin; Wu, Xueling; Yang, Zhi-Yong; Dai, Kaifan; Finzi, Andrés; Kwon, Young Do; Scheid, Johannes F.; Shi, Wei; Xu, Ling; Yang, Yongping; Zhu, Jiang; Nussenzweig, Michel C.; Sodroski, Joseph; Shapiro, Lawrence; Nabel, Gary J.; Mascola, John R.; Kwong, Peter D. (NIH); (Rockefeller); (DFCI)

2010-08-26T23:59:59.000Z

287

E-Print Network 3.0 - antiretroviral-treated hiv-infected patients...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

by carotid intima-media thickness in patients with HIV infection. Circulation 2004; 109:1603-8. 10. Lebech AM... . Jerico C, Knobel H, Calvo N et al. Subclinical carotid ......

288

Influencing HIV treatment success in India : do mobile phones really work?.  

E-Print Network [OSTI]

??Background: Sustaining treatment adherence and long-term virological suppression is a global health challenge in HIV management. Mobile phone-based interventions are increasingly harnessed to enhance medication… (more)

Shet, Anita

2014-01-01T23:59:59.000Z

289

Delivery of Multilingual mHealth Service for Control of TB/HIV in Developing Countries  

Science Journals Connector (OSTI)

A large number of people living with Tuberculosis/HIV fail treatment and develop resistance to drugs as they fail to maintain proper drug adherence. With the growing crisis of inadequate healthcare workforce in developing countries, mHealth services ...

Aishwarya Bakshi; Junhua Li; Pradeep Ray; Padmanesan Narasimhan; Kasturi Bakshi

2012-01-01T23:59:59.000Z

290

E-Print Network 3.0 - ampliscreen hiv-1 test Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

the absence... of an asterisk represents a P value greater than .05. We used the Kruskal-Wallis test to compare the 4 HIV-1... for the human immunodeficiency virus-1 ... Source:...

291

HIV-1 Tropism – A Diagnostic system based on Sequence-Relatedness  

Science Journals Connector (OSTI)

...antagonists have used the phenotyping-based Trofile test. Meanwhile various simpler-to-do genotypic tests have become available, compatible with standard...Methods: We present a new diagnostic HIV tropism test not needing DNA sequencing. The system, XTrack...

Suzanne Edwards; Heinz Stucki; Joëlle Bader; Vincent Vidal; Rolf Kaiser; Manuel Battegay; Thomas Klimkait; the Swiss HIV Cohort Study

2014-12-10T23:59:59.000Z

292

Regulatory T Cells Expanded from Hiv-1-Infected Individuals Maintain Phenotype, Tcr Repertoire and Suppressive Capacity  

E-Print Network [OSTI]

While modulation of regulatory T cell (Treg) function and adoptive Treg transfer are being explored as therapeutic modalities in the context of autoimmune diseases, transplantation and cancer, their role in HIV-1 pathogenesis ...

Angin, Mathieu

293

E-Print Network 3.0 - acquired hiv infection Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Hum Retrovirol... and HIV-2 infections. J Acquir Immune Defic Syndr 2000; 24:257- 263 21. Gilbert PB, McKeague IW, Eisen G... among 5739 ... Source: Ecole Polytechnique, Centre de...

294

E-Print Network 3.0 - adjuvanted hiv envelope Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

654 JID 2005:191 (1 March) rgp120 HIV Vaccine Study Group M A J O R A ... Source: Gilbert, Peter - Fred Hutchinson Cancer Research Center & Department of Biostatistics,...

295

The HIV-1 Tat Transactivator Contains an Arginine-Glycine-Aspartyl (RGD) Cell Adhesion Site  

Science Journals Connector (OSTI)

Since the discovery of HIV-1 as the etiologic agent of acquired immunodeficiency syndrome (Barre-Sinoussi et al, 1983; Gallo et al, 1984), enormous progress has been made toward understanding this virus organi...

David A. Brake; Christine Debouck

1991-01-01T23:59:59.000Z

296

PHARMACEUTICALLY ENGINEERED NANOPARTICLES FOR ENHANCING IMMUNE RESPONSES TO HIV-1 TAT AND GAG p24 PROTEINS.  

E-Print Network [OSTI]

??These studies were aimed at investigating the potential application of nanoparticles engineered from oil-in-water microemulsion precursors for enhancing immune responses to HIV-1 Tat and Gag… (more)

Patel, Jigna D.

2006-01-01T23:59:59.000Z

297

E-Print Network 3.0 - anti-hiv sirna delivery Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

delivery into 293 cells). However, addition of a third... to express a single anti-HIV tat shRNA in cultured lymphoma cells and found it ... Source: Kay, Mark A. -...

298

p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes  

Science Journals Connector (OSTI)

HIV-1 Tat is a potent transcriptional activator of the ... number of cellular regulatory circuits including apoptosis. Tat exerts its effects through interaction with viral ... in apoptosis and cell cycle control...

M. Saunders; M. B. Eldeen; L. Del Valle; K. Reiss; F. Peruzzi; G. Mameli…

2005-12-01T23:59:59.000Z

299

Recombinant Expression, Purification, and Characterization of an HIV-1 Tat-Human Cyclin T1 Chimera.  

E-Print Network [OSTI]

?? Efficient transcription of the human immunodeficiency virus type 1 (HIV-1) requires the interaction of the viral protein Tat with the trans-activation response (TAR) stem-loop… (more)

Fischer, Collin Lesley

2013-01-01T23:59:59.000Z

300

Investigating the Roles of Tat Specific Factor 1 in Both HIV-1 and Cellular Gene Expression.  

E-Print Network [OSTI]

?? HIV-1 relies on both viral and cellular host factors for expression of its genome. Tat specific factor 1 (Tat-SF1) was identified as a cellular… (more)

Miller, Heather Bennett

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

E-Print Network 3.0 - acute hiv-1 infection Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

< 1 2 3 4 5 > >> 61 JOURNAL OF VIROLOGY, 0022-538X9904.00 0 Summary: localization of HIV-1 regulatory proteins Nef, Tat and Rev in acutely and chronically infected lymphoid...

302

HIV-Tat Protein mediation of NeuroAIDS central nervous system pathology and behavioral deficits.  

E-Print Network [OSTI]

??This dissertation investigated the role of HIV-Tat protein in mediating behavioral dysfunction and neurodegeneration associated with NeuroAIDS. NeuroAIDS is the syndrome consisting of neuropsychological manifestations… (more)

Carey, Amanda Natalie

2010-01-01T23:59:59.000Z

303

HIV-1 Tat protein down regulates interleukin-7 receptor alpha on CD8 T cells .  

E-Print Network [OSTI]

??Expression of the IL-7 receptor alpha-chain (CD127) is decreased on CD8 T-cells in HIV infected patients and recovers in those receiving antiretroviral therapy with sustained… (more)

Faller, Elliott M

2013-01-01T23:59:59.000Z

304

HIV-1 Tat-induced interleukin-10 from monocytes is subtype specific.  

E-Print Network [OSTI]

??The human immunodeficiency virus type-1 (HIV-1) trans- acting regulatory protein (Tat) has been shown to induce interleukin-10 (IL-10) production in monocytes. IL-10, an anti-inflammatory cytokine,… (more)

Wong, Justine Karoline

2009-01-01T23:59:59.000Z

305

Nuclear magnetic resonance and dynamic characterization of the intrinsically disordered HIV-1 Tat protein.  

E-Print Network [OSTI]

??The HIV-1 transactivator of transcription (Tat) is a protein essential for both viral gene expression and virus replication. Tat is an RNA-binding protein that, in… (more)

Shojania, Shaheen

2007-01-01T23:59:59.000Z

306

Ultrastructural Analysis of Human Lymph Node Follicles After HIV-1 Infection  

Science Journals Connector (OSTI)

Infection with the human immunodeficiency virus type 1 (HIV-1) may result in persistent generalized lymphadenopathy (PGL). Lymph nodes in PGL most commonly show a florid follicular hyperplasia (FH) in which re...

Louk H.P.M. Rademakers…

1993-01-01T23:59:59.000Z

307

Efficient on-chip isolation of HIV subtypes ShuQi Wang,a  

E-Print Network [OSTI]

are living with HIV-1 worldwide, with Sub- Saharan Africa accounting for 67% of the infected population.1 on the microchannel surface with an elevated antibody density and uniform antibody orientation using a Protein G

Demirci, Utkan

308

MODELING TB AND HIV CO-INFECTIONS Lih-Ing W. Roeger Zhilan ...  

E-Print Network [OSTI]

and the overall reproductive number for the system, R = max{R1, R2}. The .... The TB/HIV model is given by the following systems of eight ordinary differential.

2009-09-25T23:59:59.000Z

309

Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys  

E-Print Network [OSTI]

Human immunodeficiency virus type 1 (HIV-1)-specific monoclonal antibodies with extraordinary potency and breadth have recently been described. In humanized mice, combinations of monoclonal antibodies have been shown to ...

Barouch, Dan H.

310

E-Print Network 3.0 - asia hiv observational Sample Search Results  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Vol. 77, No. 13 0022-538X0308.00 0 DOI: 10.1128JVI.77.13.76237634.2003 Summary: Africa and Asia. However, there have been relatively few studies of HIV-2 reverse...

311

EIA - Annual Energy Outlook 2014 Early Release  

U.S. Energy Information Administration (EIA) Indexed Site

AEO2014 Early Release Overview AEO2014 Early Release Overview Release Date: December 16, 2013 | Full Report Release Date: Early Spring 2014 | correction | Report Number: DOE/EIA-0383ER(2014) This release is an abridged version of the Annual Energy Outlook that highlights changes in the AEO Reference case projections for key energy topics. The Early Release includes data tables for the Reference case only. The AEO2014 full version will be released early Spring 2014. Download the AEO2014 Early Release Report Introduction In preparing the AEO2014 Reference case, the U.S. Energy Information Administration (EIA) evaluated a wide range of trends and issues that could have major implications for U.S. energy markets. This overview presents the AEO2014 Reference case and compares it with the AEO2013 Reference case

312

Reaction Mechanism of HIV-1 Protease by Hybrid Car-Parrinello/Classical MD Simulations  

Science Journals Connector (OSTI)

Reaction Mechanism of HIV-1 Protease by Hybrid Car-Parrinello/Classical MD Simulations ... To form the hydrated intermediate, a water molecule (WAT) must attack the carbonyl carbon of SUB15,17,18,21,31 (chemical step 1). ... This result, surprising at first, can be rationalized by realizing that a fundamental ingredient of HIV-1 PR catalytic power is the low polarity of the cleavage site environment15 that destabilizes the negatively charged Asp dyad. ...

Stefano Piana; Denis Bucher; Paolo Carloni; Ursula Rothlisberger

2004-06-25T23:59:59.000Z

313

Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins  

DOE Patents [OSTI]

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

Haynes, Barton F. (Durham, NC); Gao, Feng (Durham, NC); Korber, Bette T. (Los Alamos, NM); Hahn, Beatrice H. (Birmingham, AL); Shaw, George M. (Birmingham, AL); Kothe, Denise (Birmingham, AL); Li, Ying Ying (Hoover, AL); Decker, Julie (Alabaster, AL); Liao, Hua-Xin (Chapel Hill, NC)

2011-12-06T23:59:59.000Z

314

Early Childhood Experiences Conference on October 30  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Early Childhood Experiences Conference Community Connections: Your link to news and opportunities from Los Alamos National Laboratory Latest Issue: Dec. 2014 - Jan. 2015 All Issues...

315

STARTech Early Ventures | Open Energy Information  

Open Energy Info (EERE)

States Sector: Services Product: General Financial & Legal Services ( Partnership (investment, law etc) ) References: STARTech Early Ventures1 This article is a stub. You can...

316

Atlas of Chiefdoms and Early States  

E-Print Network [OSTI]

file published with the Atlas has variable names and valuein subsequent editions of this Atlas the simple dichotomythe title suggests, this is an atlas of chiefdoms and early

Wright, Henry T.

2006-01-01T23:59:59.000Z

317

Nanostructured Optical Photonic Crystal Biosensor for HIV Viral Load Measurement  

E-Print Network [OSTI]

Detecting and quantifying biomarkers and viruses in biological samples have broad applications in early disease diagnosis and treatment monitoring. We have demonstrated a label-free optical sensing mechanism using ...

Shafiee, Hadi

318

Biomarker Testing to Estimate Under-Reported Heavy Alcohol Consumption by Persons with HIV Initiating ART in Uganda  

E-Print Network [OSTI]

with HIV Initiating ART in Uganda Judith A. Hahn • Mwebesaantiretroviral therapy in Uganda. Almost seven percent (persons initi- ating ART in Uganda. J. A. Hahn (&) Á J. N.

Hahn, Judith A.; Bwana, Mwebesa B.; Javors, Martin A.; Martin, Jeffrey N.; Emenyonu, Nneka I.; Bangsberg, David R.

2010-01-01T23:59:59.000Z

319

Oxidative Stress and Aging in Caenorhabditis elegans  

Science Journals Connector (OSTI)

Aging is controlled by a complex interplay of both genetic and environmental factors. Because of this, many theories have been advanced that seek to explain the etiology of both cellular and organismal aging (...

Naoaki Ishii; Philip S. Hartman

2000-01-01T23:59:59.000Z

320

Paleotopography of glacial-age ice sheets  

SciTech Connect (OSTI)

This is technical comment and response to the subject of paleotophography of glacial age ice sheets. The model presented by Peltier reconstructing the paleotopography of glacial age ice sheets has implications for atmospheric general circulation models of ice age climate. In addition, the model suggests that the glacial-age Antarctic Ice Sheet was significantly larger than today`s. The commentor, Edwards, suggests there is a discrepancy between data from Papua New Guinea and the model results.

Edwards, R.L. [Univ. of Minnesota, Minneapolis, MN (United States)

1995-01-27T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

The effect of Abstinence, Being faithful to one partner, and Condom use (ABC) messages on HIV infection among youth in Uganda  

E-Print Network [OSTI]

of Health (MOH) [Uganda] and ORC Macro Uganda HIV/AIDS Sero-USA: Ministry of Health and ORC Macro, 2006. 7. Harrison A,of Health (MOH) [Uganda] and ORC Macro Uganda HIV/AIDS Sero-

Ekwaru, John Paul

2012-01-01T23:59:59.000Z

322

Patterns of Lifetime and Recent HIV Testing Among Men Who Have Sex with Men in New York City Who Use Grindr  

Science Journals Connector (OSTI)

Rates of HIV infection continue to rise for men who have sex with men (MSM), and may be partially due to lack of testing among groups at risk for HIV. Mobile applications have demonstrated promise to identify ...

H. Jonathon Rendina; Ruben H. Jimenez; Christian Grov; Ana Ventuneac…

2014-01-01T23:59:59.000Z

323

The SafeGuards Men's Survey: Report of a Survey of Philadelphia Gay and Bisexual Men's Knowledge, Attitudes, Beliefs, and Behaviors Related to HIV Infection  

Science Journals Connector (OSTI)

Objective: To characterize HIV-related knowledge, attitudes, beliefs, and behaviors in a sample of gay and bisexual men in the greater Philadelphia area, to allow rational development of HIV prev...

John Whyte; Chris Bartlett; Marcia Polanksy…

1998-09-01T23:59:59.000Z

324

The effect of Abstinence, Being faithful to one partner, and Condom use (ABC) messages on HIV infection among youth in Uganda  

E-Print Network [OSTI]

intervention on HIV incidence in Masaka, Uganda. AIDSpopulation-based cohort, Uganda. AIDS 1998;12:226-8. 10.HIV/AIDS prevention in Uganda: why has it worked? Postgrad

Ekwaru, John Paul

2012-01-01T23:59:59.000Z

325

Physical conditions on the early Earth  

Science Journals Connector (OSTI)

...for the emergence of life on the early Earth organized by S. Leach, I. W. M. Smith...Cockell Physical conditions on the early Earth Jonathan I Lunine * * ( jlunine@lpl...AZ 85721, USA. The formation of the Earth as a planet was a large stochastic process...

2006-01-01T23:59:59.000Z

326

Early LHC Prospects for Exotic Physics  

E-Print Network [OSTI]

Early LHC Prospects for Exotic Physics Tim M.P. Tait West Coast LHC @ UCSC May 21, 2010 University of California, Irvine #12;Outline Resources Comparing LHC0.5 with Tevatron Resonances Fourth Generation Quarks #12;Resources I agreed to speak about what early LHC running can tell us about some exotic physics

California at Santa Cruz, University of

327

Risk Factors for Oral HPV Infection among a High Prevalence Population of HIV-Positive and At-Risk HIV-Negative Adults  

Science Journals Connector (OSTI)

...Institute, the National Institute on Drug Abuse, and the National Institute on Deafness...HIV-1-infected adults and adolescents [Internet].Department of Health and Human Services...Riester KA, Barkan S, Richardson J, Young M, et alSexual, contraceptive, and...

Daniel C. Beachler; Kathleen M. Weber; Joseph B. Margolick; Howard D. Strickler; Ross D. Cranston; Robert D. Burk; Dorothy J. Wiley; Howard Minkoff; Susheel Reddy; Emily E. Stammer; Maura L. Gillison; and Gypsyamber D'Souza

2012-01-01T23:59:59.000Z

328

Safety of Autologous, Ex Vivo-Expanded Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Infusion in HIV-Infected Patients  

E-Print Network [OSTI]

-Lymphocyte Infusion in HIV-Infected Patients By Judy Lieberman, Paul R. Skolnik, G. Robert Parkerson III, Jessica A. Fabry, Bernard Landry, James Bethel, Jonathan Kagan, and the DATRI 006 Study Team We infused six human after the infusion suggests that antiviral CTLs of diverse specificities do not play a significant role

Lieberman, Judy

329

Human Immunodeficiency Virus Type 1 (HIV-1) Integration: a Potential Target for Microbicides To Prevent Cell-Free or Cell-Associated HIV-1 Infection  

Science Journals Connector (OSTI)

...infection, integrase (IN) inhibitors (INIs) may be suitable to prevent HIV transmission...at various stages by several classes of INIs; for example, (i) Y3 and catechols...for the first time the potential roles of INIs, particularly InSTIs, in the prevention...

Katty Terrazas-Aranda; Yven Van Herrewege; Daria Hazuda; Paul Lewi; Roberta Costi; Roberto Di Santo; Andrea Cara; Guido Vanham

2008-05-12T23:59:59.000Z

330

Radiation Therapy for Neovascular Age-related Macular Degeneration  

SciTech Connect (OSTI)

In the enormity of the public health burden imposed by age-related macular degeneration (ARMD), much effort has been directed toward identifying effective and efficient treatments. Currently, anti-vascular endothelial growth factor (VEGF) injections have demonstrated considerably efficacy in treating neovascular ARMD, but patients require frequent treatment to fully benefit. Here, we review the rationale and evidence for radiation therapy of ARMD. The results of early photon external beam radiation therapy are included to provide a framework for the sequential discussion of evidence for the usage of stereotactic radiation therapy, proton therapy, and brachytherapy. The evidence suggests that these 3 modern modalities can provide a dose-dependent benefit in the treatment of ARMD. Most importantly, preliminary data suggest that all 3 can be used in conjunction with anti-VEGF therapeutics, thereby reducing the frequency of anti-VEGF injections required to maintain visual acuity.

Kishan, Amar U. [Harvard Medical School, Boston, Massachusetts (United States)] [Harvard Medical School, Boston, Massachusetts (United States); Modjtahedi, Bobeck S.; Morse, Lawrence S. [Department of Ophthalmology and Vision Sciences, University of California, Davis, Sacramento, California (United States)] [Department of Ophthalmology and Vision Sciences, University of California, Davis, Sacramento, California (United States); Lee, Percy, E-mail: percylee@mednet.ucla.edu [Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California (United States)] [Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California (United States)

2013-03-01T23:59:59.000Z

331

Probing Multidrug-Resistance and Protein?Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors  

SciTech Connect (OSTI)

We report the design, synthesis, biological evaluation, and X-ray crystallographic analysis of a new class of HIV-1 protease inhibitors. Compound 4 proved to be an extremely potent inhibitor toward various multidrug-resistant HIV-1 variants, representing a near 10-fold improvement over darunavir (DRV). Compound 4 also blocked protease dimerization with at least 10-fold greater potency than DRV.

Ghosh, Arun K.; Xu, Chun-Xiao; Rao, Kalapala V.; Baldridge, Abigail; Agniswamy, Johnson; Wang, Yuan-Fang; Weber, Irene T.; Aoki, Manabu; Miguel, Salcedo Pedro; Amano, Masayuki; Mitsuya, Hiroaki (Kumamoto); (GSU); (Purdue); (Kumamoto)

2010-10-29T23:59:59.000Z

332

LABORATORY EVALUATION OF THREE RAPID DIAGNOSTIC TESTS FOR THE DUAL DETETION OF HIV AND TREPONEMA PALLIDUM ANTIBODIES  

Science Journals Connector (OSTI)

...research-article LABORATORY EVALUATION OF THREE RAPID DIAGNOSTIC TESTS FOR THE DUAL DETETION OF HIV AND TREPONEMA PALLIDUM ANTIBODIES...three research use only, dual HIV and syphilis rapid diagnostic tests (RDTs) was evaluated for 150 patient serum samples, as compared...

Romney M. Humphries; Jennifer S Woo; Jun Ho Chung; Anita Sokovic; Claire C. Bristow; Jeffrey D. Klausner

2014-10-08T23:59:59.000Z

333

Library versus Library Recognition and Inhibition of the HIV-1 Nef Allelome Allison Olszewski and Gregory A. Weiss*,,  

E-Print Network [OSTI]

Library versus Library Recognition and Inhibition of the HIV-1 Nef Allelome Allison Olszewski resistance. Targeting HIV Nef with small molecules screened against a combinatorial library of Nef variants studies. We asked whether a library versus library approach could simultaneously uncover structure

Weiss, Gregory A.

334

Distinct Mechanisms Regulate Exposure of Neutralizing Epitopes in the V2 and V3 Loops of HIV-1 Envelope  

Science Journals Connector (OSTI)

...donor reveal a new HIV-1 vaccine target. Science 326 :285-289. doi: 10.1126/science.1178746 . 10. Bonsignori, M , KK Hwang...glycosylated soluble cleaved HIV-1 envelope trimer. Science 342 :1484-1490. doi: 10.1126/science...

Chitra Upadhyay; Luzia M. Mayr; Jing Zhang; Rajnish Kumar; Miroslaw K. Gorny; Arthur Nádas; Susan Zolla-Pazner; Catarina E. Hioe

2014-08-27T23:59:59.000Z

335

A fluid approach to HIV A readable anthropological account of social networks in South Africa and Uganda explains differences in  

E-Print Network [OSTI]

and Uganda explains differences in the spread of sexually transmitted diseases in those countries, finds, but it was a "ritualistic act of cleansing and strengthening", says Thornton. Uganda's HIV story offers a more pleasant in its fight against the virus. Uganda reduced HIV prevalence by two- thirds during the 1990s. Causes

Cai, Long

336

won a $13.9 million award to engineer adult stem cells that produce HIV antibodies not  

E-Print Network [OSTI]

won a $13.9 million award to engineer adult stem cells that produce HIV antibodies not found bananas, rice, and cas- savas. In addition to HIV/AIDS, targeted dis- eases include malaria, dengue along the edges of these habi- tat connectors. The study also shows that small-scale obser- vations

Haddad, Nick

337

Mutual Information Analysis Reveals Coevolving Residues in Tat That Compensate for Two Distinct Functions in HIV-1  

E-Print Network [OSTI]

, Xiamen University, Xiamen 361005, China Background: It is not well understood how HIV-1 Tat performs, Tat variants that mimic HIV-1 subtypes B or C at sites 35 and 39 have evolved orthogonal strengthsMutual Information Analysis Reveals Coevolving Residues in Tat That Compensate for Two Distinct

Schaffer, David V.

338

Interaction of the phospholipid scramblase 1 with HIV-1 Tat results in the repression of Tat-dependent transcription  

SciTech Connect (OSTI)

Highlights: •PLSCR1 specifically interacted with HIV-1 Tat in vitro and in vivo. •PLSCR1 repressed Tat-dependent transactivation of the HIV-1 LTR. •Suppression of PLSCR1 expression enhanced the levels of HIV-1 transcripts. •PLSCR1 reduced the nuclear localization of Tat. -- Abstract: Human phospholipid scramblase 1 (PLSCR1) is an interferon (IFN)-stimulated gene and possesses an IFN-mediated antiviral function. We show here that PLSCR1 directly interacts with human immunodeficiency virus type-1 (HIV-1) Tat. This interaction occurs both in vitro and in vivo through amino acids 160–250 of PLSCR1. Overexpression of PLSCR1 efficiently represses the Tat-dependent transactivation of the HIV-1 long terminal repeat (LTR) and reduces the nuclear translocation of Tat. In addition, shRNA-mediated suppression of endogenous PLSCR1 expression enhances the levels of gag mRNA in an HIV-1-infected T-cell line. These findings indicate that PLSCR1 negatively regulates the Tat-dependent transactivation of the HIV-1 LTR during HIV-1 infection.

Kusano, Shuichi, E-mail: skusano@m2.kufm.kagoshima-u.ac.jp; Eizuru, Yoshito

2013-04-19T23:59:59.000Z

339

Inhibition of Both HIV-1 Reverse Transcription and Gene Expression by a Cyclic Peptide that Binds the Tat-  

E-Print Network [OSTI]

Inhibition of Both HIV-1 Reverse Transcription and Gene Expression by a Cyclic Peptide that Binds the Tat- Transactivating Response Element (TAR) RNA Matthew S. Lalonde1" , Michael A. Lobritz2" , Annette The RNA response element TAR plays a critical role in HIV replication by providing a binding site

Levin, Judith G.

340

Genetic variation of the HIV-1 integrase region in newly diagnosed anti-retroviral drug-naďve patients with HIV/AIDS in Korea  

Science Journals Connector (OSTI)

Abstract The survival time of HIV/AIDS patients in Korea has increased since HAART (highly active anti-retroviral therapy) was introduced. However, the occurrence of drug-resistant strains requires new anti-retroviral drugs, one of which, an integrase inhibitor (INI), was approved by the US Food and Drug Administration (FDA) in 2007. \\{INIs\\} have been used for therapy in many countries and are about to be employed in Korea. Therefore, it is important to identify basic mutant variants prior to the introduction of \\{INIs\\} in order to estimate their efficacy. To monitor potential drug-resistant INI mutations in Korean HIV/AIDS patients, the polymorphism of the int gene was investigated together with the pol gene using a genotypic assay for 75 randomly selected Korean HIV-1 patients newly diagnosed in 2007. The drug-resistant mutation sequences were analysed using the Stanford HIV DB and the International AIDS Society resistance testing-USA panel (IAS-USA). Seventy strains of Korean subtype B were compared with foreign subtype-B strains, and there were no significantly different variants of the int gene region in the study population. Major mutation sites in the integrase (E92Q, F121Y, G140A/S, Y143C/R, Q148H/R/K and N155H) were not detected, and only a few minor mutation sites (L74M, V151I, E157Q, V165I, I203M, S230N and D232N) were identified in 21 strains (28%). Resistance due to mutations in the pol gene was observed in a single strain (1.3%) resistant to protease inhibitors (PIs) and in four strains (5.3%) resistant to reverse transcriptase inhibitors (RTIs). In summary, this demonstrates that \\{INIs\\} will be susceptible to drug naďve HIV/AIDS patients in Korea.

J.-Y. Kim; E.-J. Kim; J.-Y. Choi; O.-K. Kwon; G.J. Kim; S.Y. Choi; S.S. Kim

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Expanded breadth of the T-cell response to mosaic HIV-1 envelope DNA vaccination  

SciTech Connect (OSTI)

An effective AIDS vaccine must control highly diverse circulating strains of HIV-1. Among HIV -I gene products, the envelope (Env) protein contains variable as well as conserved regions. In this report, an informatic approach to the design of T-cell vaccines directed to HIV -I Env M group global sequences was tested. Synthetic Env antigens were designed to express mosaics that maximize the inclusion of common potential Tcell epitope (PTE) 9-mers and minimize the inclusion of rare epitopes likely to elicit strain-specific responses. DNA vaccines were evaluated using intracellular cytokine staining (ICS) in inbred mice with a standardized panel of highly conserved 15-mer PTE peptides. I, 2 and 3 mosaic sets were developed that increased theoretical epitope coverage. The breadth and magnitude ofT-cell immunity stimulated by these vaccines were compared to natural strain Env's; additional comparisons were performed on mutant Env's, including gpl60 or gpl45 with or without V regions and gp41 deletions. Among them, the 2 or 3 mosaic Env sets elicited the optimal CD4 and CD8 responses. These responses were most evident in CD8 T cells; the 3 mosaic set elicited responses to an average of 8 peptide pools compared to 2 pools for a set of3 natural Env's. Synthetic mosaic HIV -I antigens can therefore induce T-cell responses with expanded breadth and may facilitate the development of effective T -cell-based HIV -1 vaccines.

Korber, Bette [Los Alamos National Laboratory; Fischer, William [Los Alamos National Laboratory; Wallstrom, Timothy [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

342

HIV-1 Tat induces biochemical changes in the serum of mice  

Science Journals Connector (OSTI)

The HIV-1 Tat protein is released by infected cells and has numerous biological activities which might contribute either to the impairment of the immune response or to viral dissemination and pathogenesis. To date, the effects of Tat protein on metabolites remain unclear. In this study, a metabolomic study on serum of HIV-1 Tat-induced ICR mice was performed to research the pathologic mechanism of Tat protein by using gas chromatography coupled to mass spectrometry (GC/MS). Clear separations among the HIV-1 Tat-induced mice and the inaTat-induced or control mice were observed by principal component analysis and partial least-squares discriminant analysis based on the GC/MS spectral data. Additionally, 16 significantly changed metabolites in HIV-1 Tat-induced mice were identified that are involved in multiple perturbed metabolic pathways, which contributed to the elucidation of the complex pathogenic mechanism of Tat protein and may shed new lights on future improvement of HIV-1 therapy.

Wenting Liao; Guangguo Tan; Zhenyu Zhu; Qiuli Chen; Ziyang Lou; Xin Dong; Wei Zhang; Wei Pan; Yifeng Chai

2012-01-01T23:59:59.000Z

343

EIA - Annual Energy Outlook 2013 Early Release  

Gasoline and Diesel Fuel Update (EIA)

AEO2013 Early Release Overview AEO2013 Early Release Overview Release Date: December 5, 2012 | Report Release Schedule: April 15 - May 2, 2013 | Report Number: DOE/EIA-0383ER(2013) This release is an abridged version of the Annual Energy Outlook that highlights changes in the AEO Reference case projections for key energy topics. The Early Release includes data tables for the Reference case only. The AEO2013 will be released between April 15 and May 2. See release schedule. . Download the AEO2013 Early Release Report Introduction In preparing the AEO2013 Reference case, the U.S. Energy Information Administration (EIA) evaluated a wide range of trends and issues that could have major implications for U.S. energy markets. This overview presents the AEO2013 Reference case and compares it with the AEO2012 Reference case

344

Early Detection Saves Lives | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Low-dose image scanner In 2000, the WHPP added low-dose CT scanning for early lung cancer detection to the medical screening on a pilot basis at a limited number of DOE sites,...

345

Early Work on the Positron and Muon  

Science Journals Connector (OSTI)

Early work on the positron and muon is described in an informal way with emphasis on those aspects of the work which normally would not find their way into the literature.

C. D. Anderson

1961-01-01T23:59:59.000Z

346

Siak, Piracy and Early Modern Malay Warfare  

Science Journals Connector (OSTI)

Warfare in the Malay world during the early modern period often depended on entangled relationships between families and trade partners, during which overt displays of power, feints and retreats, or raiding we...

Timothy P. Barnard

2014-01-01T23:59:59.000Z

347

Rock of Ages | Open Energy Information  

Open Energy Info (EERE)

of Ages of Ages Jump to: navigation, search Name Rock of Ages Facility Rock of Ages Sector Wind energy Facility Type Small Scale Wind Facility Status In Service Owner Rock of Ages Energy Purchaser Rock of Ages Location Graniteville VT Coordinates 44.14668574°, -72.48180896° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":44.14668574,"lon":-72.48180896,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

348

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing  

SciTech Connect (OSTI)

Antibody VRC01 is a human immunoglobulin that neutralizes about 90% of HIV-1 isolates. To understand how such broadly neutralizing antibodies develop, we used x-ray crystallography and 454 pyrosequencing to characterize additional VRC01-like antibodies from HIV-1-infected individuals. Crystal structures revealed a convergent mode of binding for diverse antibodies to the same CD4-binding-site epitope. A functional genomics analysis of expressed heavy and light chains revealed common pathways of antibody-heavy chain maturation, confined to the IGHV1-2*02 lineage, involving dozens of somatic changes, and capable of pairing with different light chains. Broadly neutralizing HIV-1 immunity associated with VRC01-like antibodies thus involves the evolution of antibodies to a highly affinity-matured state required to recognize an invariant viral structure, with lineages defined from thousands of sequences providing a genetic roadmap of their development.

Wu, Xueling; Zhou, Tongqing; Zhu, Jiang; Zhang, Baoshan; Georgiev, Ivelin; Wang, Charlene; Chen, Xuejun; Longo, Nancy S.; Louder, Mark; McKee, Krisha; O’ Dell, Sijy; Perfetto, Stephen; Schmidt, Stephen D.; Shi, Wei; Wu, Lan; Yang, Yongping; Yang, Zhi-Yong; Yang, Zhongjia; Zhang, Zhenhai; Bonsignori, Mattia; Crump, John A.; Kapiga, Saidi H.; Sam, Noel E.; Haynes, Barton F.; Simek, Melissa; Burton, Dennis R.; Koff, Wayne C.; Doria-Rose, Nicole A.; Connors, Mark; Mullikin, James C.; Nabel, Gary J.; Roederer, Mario; Shapiro, Lawrence; Kwong, Peter D.; Mascola, John R. (Tumaini); (NIH); (Duke); (Kilimanjaro Repro.); (IAVI)

2013-03-04T23:59:59.000Z

349

Participation in Research and Access to Experimental Treatments by HIV-Infected Patients  

Science Journals Connector (OSTI)

...and socially influenced health-related behavior. Those with HIV often have special needs and few options: their median household income is about one third that of typical households in the United States; they are four times as likely to be members of an underserved minority than to be white; and conventional... There is concern that minority groups and women are underrepresented in research trials and are less likely to receive experimental treatments for human immunodeficiency virus (HIV) infection. This study of patients with HIV infection in the United States found that blacks and Hispanics were less likely to participate in trials than whites and to have received experimental medications. Women were not underrepresented in trials and were as likely as men to receive experimental treatments.

Gifford A.L.; Cunningham W.E.; Heslin K.C.

2002-05-02T23:59:59.000Z

350

Equal Access Initiative: HIV/AIDS Information Resources from the National Library of Medicine  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Equal Access Initiative: Equal Access Initiative: HIV/AIDS Information Resources from the National Library of Medicine Instructors: Nicole Dancy, National Library of Medicine Wilma Templin-Branner, Oak Ridge Institute for Science and Education For Grantees of National Minority AIDS Council 2010 Equal Access Initiative Computer Grants Program United States Conference on AIDS September 11, 2010 2 Purpose ď‚„ To familiarize participants with reliable online health information from the National Library of Medicine and other reputable HIV/AIDS-related resources ď‚„ To empower participants with the skills and knowledge to better serve their clients, colleagues, and communities through the use of online HIV/AIDS-related resources 3 Objectives After completing this class, participants will be able to

351

AGE UFMG Incubator | Open Energy Information  

Open Energy Info (EERE)

Sector: Services Product: General Financial & Legal Services ( Academic Research foundation ) References: AGE-UFMG Incubator1 This article is a stub. You can help OpenEI by...

352

Unethical behaviour in homes for the aged .  

E-Print Network [OSTI]

??The purpose of the research study is to describe guidelines to counteract unethical behaviour in homes for the aged by auxiliary nurses and care workers.… (more)

O'Donoghue, Carmelia Ellen

2012-01-01T23:59:59.000Z

353

Those early days as we remember them (Part VII) - Met Lab & Early Argonne History  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

VII | Met Lab and Early Argonne History | Argonne National Laboratory VII | Met Lab and Early Argonne History | Argonne National Laboratory 1/7 Those early days as we remember them Part VlI Norman Hilberry, director of Argonne National Laboratory (seated) and Dean E. Dalquest (standing), superintendent of the laboratory's Graphic Arts division. They are examining an historic galvanometer recording of the fluctuation in a neutron density in Chicago Pile No.

354

Those early days as we remember them (Part V) - Met Lab & Early Argonne History  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

V | Met Lab and Early Argonne History | Argonne National Laboratory V | Met Lab and Early Argonne History | Argonne National Laboratory 1/3 Those early days as we remember them Part V Farrington Daniels Professor Emeritus of Chemistry The University of Wisconsin Editor's note: Dr. Farrington Daniels was Director of the Metallurgical Laboratory when it became Argonne National Laboratory on July 1, 1946. At that time he returned to his chemistry professorship at the University of

355

Innovative practices in early childhood classrooms: what makes a teacher an early adopter?  

E-Print Network [OSTI]

and the Association for Childhood Education International. However, in this study I focused on teachers who work with children in the age two through six year old age groups. These are teachers who work with pre-kindergarten and kindergarten aged children...

Marshall, Ellen

2004-09-30T23:59:59.000Z

356

Early Markets: Fuel Cells for Backup Power | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Backup Power Early Markets: Fuel Cells for Backup Power This fact sheet describes the advantages of using fuel cell technology for application in emergency backup power. Early...

357

Children's Development of Social Competences in Early Childhood Education.  

E-Print Network [OSTI]

??In this Master's thesis early environmental influences on children’s development of social competences were explored and an early childhood education programme aimed at fostering this… (more)

Kristiansen, Mikkel Bjelke

2015-01-01T23:59:59.000Z

358

A Solution NMR Investigation into the Early Events of Amelogenin...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Solution NMR Investigation into the Early Events of Amelogenin Nanosphere Self-Assembly Initiated with Sodium Chloride or A Solution NMR Investigation into the Early Events of...

359

Early Adoption of Fuel Cell Technologies | Department of Energy  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Market Transformation Early Adoption of Fuel Cell Technologies Early Adoption of Fuel Cell Technologies Many private sector organizations-grocers, banks, tire and hardware...

360

HIV/AIDS Information Resources from the National Library of Medicine-STOP  

SciTech Connect (OSTI)

The HIV/AIDS Information Resources from the National Library of Medicine training is designed specifically for the UNCFSP HBCU Screening, Testing, Outreach, and Prevention (STOP) HIV/AIDS Program project members to provide valuable health information resources from the National Library of Medicine and other reliable sources to increase awareness of the wealth of treatment information and educational materials that are available on the Internet and to improve prevention and treatment education for their clients. These resources will also meet the needs of community-based organizations

Templin-Branner, W. and N. Dancy

2010-06-15T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

SEXUALITY AND INTIMACY ISSUES AS WE AGE  

E-Print Network [OSTI]

or unprotected sex, may be sexually abused, masturbate or may abstain #12;The Importance of Sexuality and Aging ďż˝ or after breast or prostate cancer or other chronic illnesses ďż˝ Older adults may be using the internet pleasures are reserved for the young #12;Aging and the Media ďż˝ Older people are frequently portrayed

Jacobs, Lucia

362

6, 39453963, 2006 Methanol inside aged  

E-Print Network [OSTI]

. The oxidation of methane (and other hydrocarbons) can also produce methanol primarily via the self reactionACPD 6, 3945­3963, 2006 Methanol inside aged tropical biomass burning plumes G. Dufour et al. Title Chemistry and Physics Discussions First space-borne measurements of methanol inside aged tropical biomass

363

Hydration Aging of Nuclear Waste Glass  

Science Journals Connector (OSTI)

...of Nuclear Waste Glass 10...STEINDLER Chemical Engineering...60439 The aging of simulated nuclear waste glass by...nuclear waste forms can meet...simulated aging reac-tions...whether a waste formn can...pro-jected Nuclear Regulatory...STEINDLEt Chemical Engineering...Basisfor Waste Form Integrity...

J. K. BATES; L. J. JARDINE; M. J. STEINDLER

1982-10-01T23:59:59.000Z

364

New age constraints on the Middle Stone Age occupations of Kharga Oasis, Western Desert, Egypt  

E-Print Network [OSTI]

New age constraints on the Middle Stone Age occupations of Kharga Oasis, Western Desert, Egypt rocks, or tufas, exposed along the flanks of the Libyan Plateau near Kharga Oasis, Western Desert, Egypt

Asmerom, Yemane

365

Deactivation of Accelerated Engine-Aged and Field-Aged SCR Catalysts...  

Broader source: Energy.gov (indexed) [DOE]

of Accelerated Engine-Aged and Field-Aged SCR Catalysts and the Role of the DOC Adam Foster and Ke Nguyen University of Tennessee - Knoxville Bruce G. Bunting and Todd J. Toops Oak...

366

Early Fasting Is Long Lasting: Differences in Early Nutritional Conditions Reappear under Stressful  

E-Print Network [OSTI]

lead to differences in growth, reproductive success and survival. Yet, under natural conditions shorterEarly Fasting Is Long Lasting: Differences in Early Nutritional Conditions Reappear under Stressful Conditions in Adult Female Zebra Finches E. Tobias Krause1 *, Mariam Honarmand1 , Jennifer Wetzel1 , Marc

Richner, Heinz

367

LANL exceeds Early Recovery Act recycling goals  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

LANL exceeds Early Recovery Act recycling goals LANL exceeds Early Recovery Act recycling goals LANL exceeds Early Recovery Act recycling goals Lab demolition projects under the American Recovery and Reinvestment Act have recovered more than 136 tons of recyclable metal since work began last year. March 8, 2010 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

368

Early Detection Saves Lives | Department of Energy  

Broader source: Energy.gov (indexed) [DOE]

Early Detection Saves Lives Early Detection Saves Lives Early Detection Saves Lives September 20, 2012 - 2:39pm Addthis What does this mean for me? It can save your life. It can save the life of someone you love. The Worker Health Protection Program (WHPP) is the DOE's Former Worker Medical Screening Program at 13 DOE sites. WHPP provides free medical evaluations for selected occupational diseases every three years to eligible former DOE workers under a national medical protocol established by the DOE. WHPP is funded by the DOE and is operated by a consortium of the City University of New York, the United Steelworkers, and the Atomic Trades & Labor Council in association with clinical facilities in communities near DOE sites. The sites covered under WHPP include the K-25 Gaseous Diffusion Plant, Y-12 National Security Complex, Oak Ridge National

369

Energy density fluctuations in early universe  

SciTech Connect (OSTI)

The primordial nucleosinthesys of the element can be influenced by the transitions of phase that take place after the Big Bang, such as the QCD transition. In order to study the effect of this phase transition, in this work we compute the time evolution of thermodynamical quantities of the early universe, focusing on temperature and energy density fluctuations, by solving the relevant equations of motion using as input the lattice QCD equation of state to describe the strongly interacting matter in the early universe plasma. We also study the effect of a primordial strong magnetic field by means of a phenomenological equation of state. Our results show that small inhomogeneities of strongly interacting matter in the early Universe are moderately damped during the crossover.

Guardo, G. L.; Ruggieri, M. [Department of Physics and Astronomy, University of Catania, Catania (Italy); Greco, V. [Department of Physics and Astronomy, University of Catania, Catania, Italy and INFN - Laboratori Nazionali del Sud, Catania (Italy)

2014-05-09T23:59:59.000Z

370

Energy density fluctuations in Early Universe  

E-Print Network [OSTI]

The primordial nucleosinthesys of the element can be influenced by the transitions of phase that take place after the Big Bang, such as the QCD transition. In order to study the effect of this phase transition, in this work we compute the time evolution of thermodynamical quantities of the early universe, focusing on temperature and energy density fluctuations, by solving the relevant equations of motion using as input the lattice QCD equation of state to describe the strongly interacting matter in the early universe plasma. We also study the effect of a primordial strong magnetic field by means of a phenomenological equation of state. Our results show that small inhomogeneities of strongly interacting matter in the early Universe are moderately damped during the crossover.

Guardo, G L; Ruggieri, M

2014-01-01T23:59:59.000Z

371

Supersymmetry in the Very Early Universe  

E-Print Network [OSTI]

Supersymmetric flat directions can have a number of important consequences in the very early universe. Depending on the form of the SUSY breaking potential arising from the finite energy density at early times, coherent production of scalar condensates can result along such directions. This leads a cosmological disaster for Polonyi type flat directions with only Planck suppressed couplings, but can give rise to the baryon asymmetry for standard model flat directions. Flat directions are also natural candidates to act as inflatons. Achieving density fluctuations of the correct magnitude generally requires an additional hidden SUSY breaking sector.

Scott Thomas

1995-06-24T23:59:59.000Z

372

Gamma-Ray Burst Early Afterglows  

E-Print Network [OSTI]

The successful launch and operation of NASA's Swift Gamma-Ray Burst Explorer open a new era for the multi-wavelength study of the very early afterglow phase of gamma-ray bursts (GRBs). GRB early afterglow information is essential to explore the unknown physical composition of GRB jets, the link between the prompt gamma-ray emission and the afterglow emission, the GRB central engine activity, as well as the immediate GRB environment. Here I review some of the recent theoretical efforts to address these problems and describe how the latest Swift data give answers to these outstanding questions.

Bing Zhang

2005-09-19T23:59:59.000Z

373

Part cost estimation at early design phase  

Science Journals Connector (OSTI)

Abstract Although 70% of part cost is determined during the early design stage, designers rarely accurately estimate the costs of their designs. Based on extensive literature review, in-depth industrial survey and close collaboration with multiple manufacturers, forty factors were identified as governing part cost and ranked according to cost impact. Based on parameter ranking and availability at the early stages of design, a cost estimator for designers is proposed. As the design progresses and more parameters become available, a more accurate cost model is derived and proposed to manufacturers. Results are analyzed and compared to actual manufacturing costing demonstrating good fit.

Gila Molcho; Asher Cristal; Moshe Shpitalni

2014-01-01T23:59:59.000Z

374

Grandmothers' Productivity and the HIV/AIDS Pandemic in Sub-Saharan Africa  

E-Print Network [OSTI]

, and in a population of a 1.3 million there are nearly 50,000 children who have lost one or both parents to HIV of extended families take on the parenting responsibilities for children orphaned by AIDS or whose parents are too sick to parent them (Ntozi 1997, Williams and Tumwekwase 2001, Monasch and Boerma 2004). Children

Bock, John

375

Effect of Multimerization on Membrane Association of Rous Sarcoma Virus and HIV-1 Matrix Domain Proteins  

Science Journals Connector (OSTI)

...each other, making the overall shape of Gag like that of a horseshoe (80, 81). Moreover, from low-angle neutron scattering analyses of HIV-1 Gag bound to a tethered membrane, it appears that the horseshoe shape is maintained, implying...

Robert A. Dick; Elena Kamynina; Volker M. Vogt

2013-10-09T23:59:59.000Z

376

Structural properties of the histidine-containing loop in HIV-1RNase H  

SciTech Connect (OSTI)

The isolated HIV-1 RNase H domain is inactive. This inactivity has been linked to the lack of structure in the C-terminus of the isolated domain. His539 residing in a loop preceding the C-terminal Helix was studies by NMR to determine the stability and conformational properties of this region.

Kern, G.; Pelton, J.; Marqusee, S.; Kern, D.

2001-01-02T23:59:59.000Z

377

HIV-1 Tat modulates T-bet expression and induces Th1 type of immune response  

SciTech Connect (OSTI)

The HIV-1 transactivator Tat performs various viral and cellular functions. Primarily, it induces processive transcription from the HIV-1 LTR promoter. However, Tat secreted from infected cells is known to activate uninfected lymphocytes through receptors. To further delineate the specific target genes, extracellular Tat was expressed on the cell membrane of stimulator cells and co-cultured with human PBMCs. Along with induced CD4{sup +} T cell proliferation and IFN-{gamma} secretion, there was strong upregulation of T-bet expression which is majorly implicated in generating T{sub H}1 type of immune response. To further delineate the effect of extracellular Tat on HIV replication, both p24 analysis and in vivo GFP expression were performed. There was a significant inhibition of HIV-1 replication in human CEM-GFP cell line and hPBMCs. Thus, for the first time we report that apart from its transactivation activity, extracellular Tat acts as a costimulatory molecule that affects viral replication by modulating host immune response through induction of T-bet expression and IFN-{gamma} secretion.

Kulkarni, Asavari [National Center for Cell Science, Pune University Campus, Ganeshkhind, Pune 411 007 (India); Ravi, Dyavar S. [National Center for Cell Science, Pune University Campus, Ganeshkhind, Pune 411 007 (India); Singh, Kamini [National Center for Cell Science, Pune University Campus, Ganeshkhind, Pune 411 007 (India); Rampalli, Shravanti [National Center for Cell Science, Pune University Campus, Ganeshkhind, Pune 411 007 (India); Parekh, Vrajesh [National Center for Cell Science, Pune University Campus, Ganeshkhind, Pune 411 007 (India); Mitra, Debashis [National Center for Cell Science, Pune University Campus, Ganeshkhind, Pune 411 007 (India); Chattopadhyay, Samit [National Center for Cell Science, Pune University Campus, Ganeshkhind, Pune 411 007 (India)]. E-mail: samit@nccs.res.in

2005-04-08T23:59:59.000Z

378

ASTROCYTE-ENDOTHELIAL INTERACTIONS: IMPLICATIONS FOR HIV-ASSOCIATED NEUROCOGNITIVE DISORDER  

E-Print Network [OSTI]

(MCP-1), the two hallmark features of HAND. To further understand these observations and explore the role of PDGF-BB regulation in HAND, our central hypothesis is that exposure of astrocytes to HIV transactivating protein Tat results in the release...

Bethel-Brown, Crystal

2011-08-31T23:59:59.000Z

379

Crystal structure of HIV-1 Tat complexed with human P-TEFb  

SciTech Connect (OSTI)

Regulation of the expression of the human immunodeficiency virus (HIV) genome is accomplished in large part by controlling transcription elongation. The viral protein Tat hijacks the host cell's RNA polymerase II elongation control machinery through interaction with the positive transcription elongation factor, P-TEFb, and directs the factor to promote productive elongation of HIV mRNA. Here we describe the crystal structure of the Tat-P-TEFb complex containing HIV-1 Tat, human Cdk9 (also known as CDK9), and human cyclin T1 (also known as CCNT1). Tat adopts a structure complementary to the surface of P-TEFb and makes extensive contacts, mainly with the cyclin T1 subunit of P-TEFb, but also with the T-loop of the Cdk9 subunit. The structure provides a plausible explanation for the tolerance of Tat to sequence variations at certain sites. Importantly, Tat induces significant conformational changes in P-TEFb. This finding lays a foundation for the design of compounds that would specifically inhibit the Tat-P-TEFb complex and block HIV replication.

Tahirov, Tahir H.; Babayeva, Nigar D.; Varzavand, Katayoun; Cooper, Jeffrey J.; Sedore, Stanley C.; Price, David H. (Nebraska-Med); (Iowa)

2010-08-23T23:59:59.000Z

380

Ex Vivo Comparison of Microbicide Efficacies for Preventing HIV-1 Genomic Integration in Intraepithelial Vaginal Cells  

Science Journals Connector (OSTI)

...microbicide development pipeline. They include more HIV-specific...tissues from vaginal-repair surgeries performed in...by-product of vaginal-repair surgeries (4, 29...microbicides in the development pipeline. We propose that this...R. Edwards. 2005. Repair of the anterior vaginal...

M. Juliana McElrath; Lamar Ballweber; Andrew Terker; Allison Kreger; Polachai Sakchalathorn; Barry Robinson; Michael Fialkow; Gretchen Lentz; Florian Hladik

2009-11-30T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

Extreme Genomics By Scouring the Genomes of 50 HIV-Resistant People, Study  

E-Print Network [OSTI]

Extreme Genomics By Scouring the Genomes of 50 HIV-Resistant People, Study Takes Aim at Rare Gene Genome Variation, and his colleagues think that the complete genome sequences of those fortunate few against the viral strain that usually infects humans. That's because the CCR5 protein is Extreme Genomics

Dolbow, John

382

Mycobacterium tuberculosis Transmission in a Country with Low Tuberculosis Incidence: Role of Immigration and HIV Infection  

Science Journals Connector (OSTI)

...of Immigration and HIV Infection Lukas Fenner a Sebastien Gagneux b c Peter Helbling...Groups Address correspondence to Lukas Fenner, lfenner@ispm.unibe.ch . a Institute...Central coordinating team members were Lukas Fenner and Matthias Egger (Institute of Social...

Lukas Fenner; Sebastien Gagneux; Peter Helbling; Manuel Battegay; Hans L. Rieder; Gaby E. Pfyffer; Marcel Zwahlen; Hansjakob Furrer; Hans H. Siegrist; Jan Fehr; Marisa Dolina; Alexandra Calmy; David Stucki; Katia Jaton; Jean-Paul Janssens; Jesica Mazza Stalder; Thomas Bodmer; Beatrice Ninet; Erik C. Böttger; Matthias Egger; for the Swiss HIV Cohort; Molecular Epidemiology of Tuberculosis Study Groups

2011-11-23T23:59:59.000Z

383

Medical Progress: Age-Related Macular Degeneration  

Science Journals Connector (OSTI)

...blurred vision, visual scotomas, decreased contrast sensitivity, abnormal dark adaptation (difficulty adjusting from bright to dim lighting), and the need for brighter light or additional magnification to read small print. Gradual, insidious visual loss with central or pericentral visual scotomas typically... Age-related macular degeneration is the leading cause of irreversible blindness in people 50 years of age or older in the developed world. This article reviews the clinical and histopathological features of age-related macular degeneration and its genetics and epidemiology and discusses current management options and research advances.

Jager R.D.Mieler W.F.Miller J.W.

2008-06-12T23:59:59.000Z

384

Computational Age Dating of Special Nuclear Materials  

SciTech Connect (OSTI)

This slide-show presented an overview of the Constrained Progressive Reversal (CPR) method for computing decays, age dating, and spoof detecting. The CPR method is: Capable of temporal profiling a SNM sample; Precise (compared with known decay code, such a ORIGEN); Easy (for computer implementation and analysis). ? We have illustrated with real SNM data using CPR for age dating and spoof detection. If SNM is pure, may use CPR to derive its age. If SNM is mixed, CPR will indicate that it is mixed or spoofed.

None

2012-06-30T23:59:59.000Z

385

Overview of the ALCF Early Science Program  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

ALCF Early Science Program ALCF Early Science Program Timothy J . W illiams Argonne L eadership C ompu2ng F acility 2013 M iraCon W orkshop Wednesday 3 /4/2013 Session: 3 :45---4:30pm 2 § 16 projects - Large t arget a lloca-ons - Postdoc § Proposed r uns b etween M ira a cceptance a nd start of producCon § 2 billion core---hours to burn in a few months First in Mira Queue: Early Science Program h3p://esp.alcf.anl.gov 3 § MoCvaCons f or E SP: - Prepare k ey a pplica-ons f or t he a rchitecture a nd s cale o f M ira - Solidify l ibraries a nd i nfrastructure - Iden-fy s ystem p roblems § 16 Early Science projects were chosen based on computaConal and scienCfic reviews. § The p rojects h ave a r unning s tart f or d elivery o f e xciCng n ew s cience - Postdocs w ere a ssigned t o t he p rojects - ALCF

386

Evolution of self-incompatibility: Early Views  

E-Print Network [OSTI]

Evolution of self-incompatibility: Early Views: Whitehouse (1950): 1. Sudden rise of angiosperms by Whitehouse (1950). Isolation of components of the self-incompatibilities paved the way to study the evolution of SIs Matton et al. (1994): Molecular data supports Bateman. Three self-incompatibility systems

Bhattacharyya, Madan Kumar

387

Heart Disease and Early Heart Attack Care  

E-Print Network [OSTI]

Heart Disease and Early Heart Attack Care Pamela Kostic, RN, CCCC, Chest Pain Coordinator, Stony Risk Factors · EHAC & Prevention #12;Heart disease includes a number of problems affecting the heart and the blood vessels in the heart. #12;Types of heart disease include: · Coronary artery disease (CAD) · Angina

Ohta, Shigemi

388

Targets for early discoveries at the LHC  

E-Print Network [OSTI]

Targets for early discoveries at the LHC Lian-Tao Wang University of Chicago 04/11/2011 Monday to emphasize less "well-known" or less "well-mentioned" but not "strange" channels. In the next year or so, LHC

389

"AGE AND AREA" IN RELATION TO EXTINCTION  

Science Journals Connector (OSTI)

...the end of the Carboniferous. CHARLES J. CHAMBERLAIN UNIVERSITY OF CIHICAGO "'AGE AND AREA" IN RELATION TO EXTINCTION T:EERE are few generalizations in regard to the geographical distribution of species which have aroused so much interest and elicited...

S. J. Holmes

1925-01-23T23:59:59.000Z

390

Aging of polymeric composites : a literature review  

E-Print Network [OSTI]

Due to their increased use in today's society, an extensive survey was undertaken in this report to condense what's been, thus far, discovered as to the effects of aging on polymeric composites. Special emphasis was placed ...

Trevińo-Garrido, Margie N

2013-01-01T23:59:59.000Z

391

Population ageing: what should we worry about?  

Science Journals Connector (OSTI)

...rather than on average health, and therefore on issues...the affordability of health and residential care expenditures rather than...improvements in average health at each age. New theoretical...need for pension system reforms that remove barriers...

2009-01-01T23:59:59.000Z

392

Fracture, aging and disease in bone  

E-Print Network [OSTI]

by enhancing the materials resistance to microstructuralgrowth resistance of microcracking brittle materials. J. Am.resistance to fracture of the Page 4 Fracture, Aging and Disease in Bone underlying material.

Ager, J.W.; Balooch, G.; Ritchie, R.O.

2006-01-01T23:59:59.000Z

393

Aging Dynamics in Mixed Nanoclay Dispersions  

Science Journals Connector (OSTI)

This chapter investigates the ergodicity breaking and aging dynamics in mixture of colloidal clays, Laponite (L) and Montmorillonite (MMT). The relaxation dynamics has been studied systematically through the l...

Ravi Kumar Pujala

2014-01-01T23:59:59.000Z

394

Aging Characteristics of Polyurethane Foam Insulation  

Science Journals Connector (OSTI)

Closed-cell polyurethane foam insulation displays a time-dependent thermal conductivity characteristic commonly known as aging. Freshly made foam has a relatively low thermal conductivity, which ... in order to e...

J. Navickas; R. A. Madsen

1977-01-01T23:59:59.000Z

395

Ageing, Debt, and Growth Crises: Two Forerunners  

Science Journals Connector (OSTI)

High levels of public debt and frustratingly low growth in Japan and Italy have a common root: an ... chapter follows the reactions of ageing corporations, households, and governments to show that debt crises...

Martin Schulz

2014-01-01T23:59:59.000Z

396

Aging and weathering of cool roofing membranes  

E-Print Network [OSTI]

Canada ABSTRACT Aging and weathering can reduce the solarsolar reflectance of 25 weathered roofing membranes from 25 cities across the United States and Canada.Canada. The LBNL study included measuring the spectral solar

2005-01-01T23:59:59.000Z

397

Hyper-Aging Dynamics of Nanoclay Suspension  

Science Journals Connector (OSTI)

Hyper-Aging Dynamics of Nanoclay Suspension ... Aqueous suspension of nanoclay Laponite undergoes structural evolution as a function of time, which enhances its elasticity and relaxation time. ... Typically, we observe that the monotonic evolution of elastic modulus shifts to lower aging times, while maxima in viscous moduli get progressively broader for experiments carried out on a later date after preparation (idle time) of the nanoclay suspension. ...

A. Shahin; Yogesh M Joshi

2012-03-13T23:59:59.000Z

398

Those early days as we remember them (Part VI) - Met Lab & Early Argonne History  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

VI | Met Lab and Early Argonne History | Argonne National Laboratory VI | Met Lab and Early Argonne History | Argonne National Laboratory 1/2 Those early days as we remember them Part Vl Lester C. Furney (second from right), who formerly handled public relations at Argonne and is author of the article below, is pictured here in February 1956 with (l to r) Major General D. J. Keirn, Major General James McCormack, Jr. (Ret.), and Lt. General James H. Doolittle (Ret.) during a

399

Morbidity from HIV-associated neurocognitive disorders (HAND) continues to be a medical concern despite effective HAART.  

E-Print Network [OSTI]

+ lymphocyte cell count, APOE 4 genotype, fasting lipid profile, fasting plasma glucose, and 2-hour oral, current antiviral therapy, height, weight, waist circumference, blood pressure, plasma HIV viral load, CD4

Thompson, Paul

400

Examining Public Health System Responses to the Chronic Diseases of HIV/AIDS and Diabetes: Experiences from Mexico and Brazil  

E-Print Network [OSTI]

A. Cohn, Health reform in Brazil: lessons to consider. Am JPetersen, M.L. , et al. , Brazil, in The HIV Pandemic: localof the AIDS epidemic in Brazil: principal epidemiological

Gidi, Virginia Eve

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

An agent-based approach to HIV/AIDS epidemic modeling : a case study of Papua New Guinea  

E-Print Network [OSTI]

Since AIDS was first discovered, mathematical models of the transmission dynamics of HIV have been developed to determine the drivers of the epidemic. It has become apparent that the most profound factor in the proliferation ...

Rhee, Alisa Joy

2006-01-01T23:59:59.000Z

402

Empirical Evidence for Synchrony in the Evolution of TB Cases and HIV plus Contacts among the San Francisco Homeless  

E-Print Network [OSTI]

The re-emergence of tuberculosis (TB) in the mid-1980s in many parts of the world, including the United States, is often attributed to the emergence and rapid spread of human immunodeficiency virus (HIV) and acquired ...

Mohtashemi, Mojdeh

403

Envelope Deglycosylation Enhances Antigenicity of HIV-1 gp41 Epitopes for Both Broad Neutralizing Antibodies and Their Unmutated Ancestor Antibodies  

E-Print Network [OSTI]

The HIV-1 gp41 envelope (Env) membrane proximal external region (MPER) is an important vaccine target that in rare subjects can elicit neutralizing antibodies. One mechanism proposed for rarity of MPER neutralizing antibody generation is lack...

Ma, Ben-Jiang; Alam, S. Munir; Go, Eden P.; Lu, Xiaozhi; Desaire, Heather; Tomaras, Georgia D.; Bowman, Cindy; Sutherland, Laura L.; Scearce, Richard M.; Santra, Sampa; Letivn, Norman L.; Kepler, Thomas B.; Liao, Hua-Xin; Haynes, Barton F.

2011-09-01T23:59:59.000Z

404

żMaybe his blood is still strongż: a qualitative study among HIV-sero-discordant couples on ART in rural Uganda  

E-Print Network [OSTI]

of HIV-discordant couples in Uganda. AIDS Care 2005, 17:999–couples receiving care in Uganda. BMC Public Health 2010,and their partners in rural Uganda. BMC Public Health 2011,

King, Rachel; Wamai, Nafuna; Khana, Kenneth; Johansson, Eva; Lindkvist, Pille; Bunnell, Rebecca

2012-01-01T23:59:59.000Z

405

The N-terminus of HIV-1 Tat protein is essential for Tat-TAR RNA interaction  

Science Journals Connector (OSTI)

The human HIV transactivator protein Tat is essential for efficient viral transcription that ... occurs by a complex mechanism involving interaction of Tat with the TAR RNA element. This interaction ... , cyclin ...

O. Chaloin; J. -C. Peter; J. -P. Briand…

2005-02-01T23:59:59.000Z

406

Role of the cysteine-rich region of HIV tat protein on its trans-activational ability  

Science Journals Connector (OSTI)

The tat protein of human immunodeficiency virus (HIV) has a characteristic cysteine-rich region containing ... this region was investigated by creation of several tat gene mutants. The activities of the novel tat

Satoshi Kubota; Sei-Ichi Endo; Masatoshi Maki; Masakazu Hatanaka

1989-03-01T23:59:59.000Z

407

The HIV-1 Tat Protein and Adverse Drug Reactions: A model system utilizing Jurkat T cells and sulphamethoxazole-hydroxylamine.  

E-Print Network [OSTI]

??In 2009 approximately 2.6 million people became infected with the Human Immunodeficiency Virus (HIV). In addition to the estimated 33.3 million people currently living with… (more)

Adeyanju, Kaothara

2011-01-01T23:59:59.000Z

408

Mutational Analysis of the HIV-1 Tat Protein and its Role in Downregulating CD127 on CD8 T Cells .  

E-Print Network [OSTI]

??HIV Tat protein downregulates surface expression of the interleukin-7 receptor alpha-chain (CD127) on CD8 T cells resulting in impaired T cell proliferation and cytolytic capacity.… (more)

Sugden, Scott M.

2013-01-01T23:59:59.000Z

409

Misalignment between cold gas and stellar components in early-type galaxies  

E-Print Network [OSTI]

Recent work suggests blue ellipticals form in mergers and migrate quickly from the blue cloud of star-forming galaxies to the red sequence of passively evolving galaxies, perhaps as a result of black hole feedback. Such rapid reddening of stellar populations implies that large gas reservoirs in the pre-merger star-forming pair must be depleted on short time scales. Here we present pilot observations of atomic hydrogen gas in four blue early-type galaxies that reveal increasing spatial offsets between the gas reservoirs and the stellar components of the galaxies, with advancing post-starburst age. Emission line spectra show associated nuclear activity in two of the merged galaxies, and in one case radio lobes aligned with the displaced gas reservoir. These early results suggest that a kinetic process (possibly feedback from black hole activity) is driving the quick truncation of star formation in these systems, rather than a simple exhaustion of gas supply.

Wong, O Ivy; Józsa, G I G; Urry, C M; Lintott, C J; Simmons, B D; Kaviraj, S; Masters, K L

2015-01-01T23:59:59.000Z

410

Prokaryotic Production of Human Immunodeficiency VirusType 1 Subtype C Tat, Nef and Reverse Transcriptase andInvestigation of Antibody Responses to these proteins inHIV-1 Infected Individuals as well as Macaques Vaccinatedwith SAAVI DNA-C/C2 and SAAVI MVA-C.  

E-Print Network [OSTI]

??The purified Tat, Nef and RT recombinant proteins were used as antigens to investigate the prevalence of HIV-1 antibodies in sera of HIV-1 infected people.… (more)

Kgatle, M M

2010-01-01T23:59:59.000Z

411

Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Market Transformation Market Transformation Printable Version Share this resource Send a link to Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies to someone by E-mail Share Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Facebook Tweet about Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Twitter Bookmark Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Google Bookmark Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Delicious Rank Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Digg Find More places to share Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on AddThis.com... Early Adoption of Fuel Cells Early Market Applications for Fuel Cells

412

Fundamental properties of nearby single early B-type stars  

E-Print Network [OSTI]

Fundamental parameters of a sample of 26 apparently slowly-rotating single early B-type stars in the solar neighbourhood are presented and compared to high-precision data from detached eclipsing binaries (DEBs). The data are used to discuss the evolutionary status of the stars in context of the most recent Geneva grid of models. Evolutionary masses plus radii and luminosities are determined to better than typically 5%, 10%, and 20% uncertainty, respectively, facilitating the mass-radius and mass-luminosity relationships to be recovered with a similar precision as derived from DEBs. Good agreement between evolutionary and spectroscopic masses is found. Absolute visual and bolometric magnitudes are derived to typically 0.15-0.20mag uncertainty. Metallicities are constrained to better than 15-20% uncertainty and tight constraints on evolutionary ages of the stars are provided. Signatures of mixing with CN-cycled material are found in 1/3 of the sample stars. Typically, these are consistent with the amount predic...

Nieva, Maria-Fernanda

2014-01-01T23:59:59.000Z

413

Early modern human settlement of Europe north of the Alps occurred 43,500 years ago in a cold steppe-type environment  

E-Print Network [OSTI]

. White M, Pettitt P (2012) Ancient Digs and Modern Myths: The Age and Context of the Kent's Cavern 4 Maxilla and the Earliest Homo sapiens Specimens in Europe. European Journal of Archaeology 15:392–420. 12. Hublin JJ (2013) The Makers of the Early Upper...

Nigst, Philip R.; Haesaerts, Paul; Damblon, Freddy; Frank-Fellner, Christa; Mallol, Carolina; Götzinger, Michael; Niven, Laura; Trnka, Gerhard; Hublin, Jean-Jacques

2014-09-22T23:59:59.000Z

414

Predicting the future: A fish story. Prokaryotic genetics has an illustrious past. In its early days, it helped us learn how  

E-Print Network [OSTI]

Predicting the future: A fish story. Prokaryotic genetics has an illustrious past. In its early. But first the fish story...... A fish story - Once upon a time, some very bright and ambitious fishermen set out to catch the very biggest fish of their age ­ the hereditary material, mutation, replication

California at Davis, University of

415

Bulk Flows and End of the Dark Ages with the SKA  

E-Print Network [OSTI]

The early Universe is a precious probe of the birth of primordial objects, first star formation events and consequent production of photons and heavy elements. Higher-order corrections to the cosmological linear perturbation theory predicts the formation of coherent supersonic gaseous streaming motions at decoupling time. These bulk flows impact the gas cooling process and determine a cascade effect on the whole baryon evolution. By analytical estimates and N-body hydrodynamical chemistry numerical simulations including atomic and molecular evolution, gas cooling, star formation, feedback effects and metal spreading for individual species from different stellar populations according to the proper yields and lifetimes, we discuss the role of these primordial bulk flows at the end of the dark ages and their detectable impacts during the first Gyr in view of the upcoming SKA mission. Early bulk flows can inhibit molecular gas cooling capabilities, suppressing star formation, metal spreading and the abundance of ...

Maio, Umberto; Koopmans, Leon V E

2015-01-01T23:59:59.000Z

416

Spectral detection of multiple stellar populations in z~1 early-type galaxies  

E-Print Network [OSTI]

We present a spectroscopic analysis based on measurements of two mainly age-dependent spectrophotometric indices in the 4000A rest frame region, i.e. H+K(CaII) and Delta4000, for a sample of 15 early-type galaxies (ETGs) at 0.7 energy distribution (SED) fitting are not consistent with those derived from the two indices. We then hypothesized that the stellar content of many galaxies is made of two stellar components with different ages. The double-component analysis, performed by taking into account both the index values and the observed SED, fully explains the observational data and improves the results of the standard one-component SED fitting in 9 out o...

Lonoce, I; Saracco, P; Gargiulo, A; Tamburri, S

2014-01-01T23:59:59.000Z

417

Development of a receptor model for efficient in silico screening of HIV-1 integrase inhibitors  

Science Journals Connector (OSTI)

Abstract Integrase (IN) is a key viral enzyme for the replication of the type-1 human immunodeficiency virus (HIV-1), and as such constitutes a relevant therapeutic target for the development of anti-HIV agents. However, the lack of crystallographic data of HIV IN complexed with the corresponding viral DNA has historically hindered the application of modern structure-based drug design techniques to the discovery of new potent IN inhibitors (INIs). Consequently, the development and validation of reliable HIV IN structural models that may be useful for the screening of large databases of chemical compounds is of particular interest. In this study, four HIV-1 IN homology models were evaluated respect to their capability to predict the inhibition potency of a training set comprising 36 previously reported \\{INIs\\} with IC50 values in the low nanomolar to the high micromolar range. Also, 9 inactive structurally related compounds were included in this training set. In addition, a crystallographic structure of the IN-DNA complex corresponding to the prototype foamy virus (PFV) was also evaluated as structural model for the screening of inhibitors. The applicability of high throughput screening techniques, such as blind and ligand-guided exhaustive rigid docking was assessed. The receptor models were also refined by molecular dynamics and clustering techniques to assess protein sidechain flexibility and solvent effect on inhibitor binding. Among the studied models, we conclude that the one derived from the X-ray structure of the PFV integrase exhibited the best performance to rank the potencies of the compounds in the training set, with the predictive power being further improved by explicitly modeling five water molecules within the catalytic side of IN. Also, accounting for protein sidechain flexibility enhanced the prediction of inhibition potencies among the studied compounds. Finally, an interaction fingerprint pattern was established for the fast identification of potent IN inhibitors. In conclusion, we report an exhaustively validated receptor model if IN that is useful for the efficient screening of large chemical compounds databases in the search of potent HIV-1 IN inhibitors.

Mario A. Quevedo; Sergio R. Ribone; Margarita C. Brińón; Wim Dehaen

2014-01-01T23:59:59.000Z

418

Feeding the periphery : modeling early Bronze Age economies and the cultural landscape of the Faynan District, Southern Jordan  

E-Print Network [OSTI]

Life of Palestine: Israel and Jordan. Ronald, New York.Use in the Wadi Faynan, Southern Jordan: The Third Season ofin the Wadi Faynan, Southern Jordan: The Second Season of

Muniz, Adolfo A.

2007-01-01T23:59:59.000Z

419

The Arabidopsis onset of leaf death5 Mutation of Quinolinate Synthase Affects Nicotinamide Adenine Dinucleotide Biosynthesis and Causes Early Ageing  

Science Journals Connector (OSTI)

...a Molecular Biology of Plants, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9751 NN Haren, The Netherlands...Molecular Biology of Plants, Groningen Biomolecular Sciences and Biotechnology...

Jos H.M. Schippers; Adriano Nunes-Nesi; Roxana Apetrei; Jacques Hille; Alisdair R. Fernie; Paul P. Dijkwel

2008-10-31T23:59:59.000Z

420

p53 Mutations and Chromosome Instability in Basal Cell Carcinomas Developed at an Early or Late Age  

Science Journals Connector (OSTI)

...minimally and with difficulty; type III, burn minimally, tan gradually and uniformly; type IV, burn minimally, alwaystan well. 748 D p53w...K-W., Huang, D. P., and Lau, K-M. pitS gene alterations in nasopharyngeal carcinoma...

Mariarosaria D'Errico; Angelo S. Calcagnile; Rosamaria Corona; Monica Fucci; Giorgio Annessi; Giannandrea Baliva; Maria Elena Tosti; Paolo Pasquini; and Eugenia Dogliotti

1997-02-15T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Early-age concrete temperature and moisture relative to curing effectiveness and projected effects on selected aspects of slab behavior  

E-Print Network [OSTI]

-desiccation. A full scale concrete pavement test study was conducted at the FAA National Airport Pavement Test Facility (NAPTF) near Atlantic City, New Jersey. In this study, the material properties, i.e. thermal conductivity and moisture diffusivity, were...

Ye, Dan

2009-05-15T23:59:59.000Z

422

EIA - Annual Energy Outlook 2011 Early Release  

Gasoline and Diesel Fuel Update (EIA)

April 2012 April 2012 | Report Number: DOE/EIA-0383ER(2012) This release is an abridged version of the Annual Energy Outlook that highlights changes in the AEO Reference case projections for key energy topics. The Early Release includes data tables for the Reference case only. The full AEO2011 will be released April 26, 2011. Download the AEO2011 Early Release Report Introduction In preparing the AEO2011, EIA evaluated a wide range of trends and issues that could have major implications for U.S. energy markets. This overview focuses primarily on one case, the AEO2011 Reference case, which is presented and compared with the AEO2010 Reference case released in December 2009 (see Table 1). Because of the uncertainties inherent in any energy market projection, the Reference case results should not be viewed in

423

EIA - Annual Energy Outlook 2008 (Early Release)  

Gasoline and Diesel Fuel Update (EIA)

Release) > Year-by-Year Reference Case Tables (2005-2030) Release) > Year-by-Year Reference Case Tables (2005-2030) Annual Energy Outlook 2008 with Projections to 2030 (Early Release) The early release version of the AEO2008 reference case does not include consideration of the H.R.6, "Energy Independence and Security Act of 2007," that was signed into law on December 19, 2007. EIA is compiling a revised reference case that includes the impact of H.R.6. Year-by-Year Reference Case Tables (2005-2030) Table Title Formats Summary Reference Case Tables Year-by-Year Reference Case Tables Table 1. Total Energy Supply and Disposition Summary Table 2. Energy Consumption by Sector and Source Table 3. Energy Prices by Sector and Source Table 4. Residential Sector Key Indicators and Consumption Table 5. Commercial Sector Indicators and Consumption

424

A survey of early warning technologies  

SciTech Connect (OSTI)

This paper presents a survey of technologies useful in providing early warning in physical security systems. Early warning is important in virtually all types of security systems whether they are used for temporary (tactical, portable, or semi-permanent) applications, border warning, fixed-site detection, or standoff surveillance detection. With the exception of the standoff surveillance detection systems, all systems discussed in this paper usually involve a moving target. The fact that a person(s) to be detected in a standoff surveillance scenario is not moving presents challenging problems and requires different applications of technology. The technologies commonly used to detect moving targets and some suggestions for detection of stationary targets are addressed in this paper.

Smith, G.D.; Arlowe, H.D.; Williams, J.D.

1995-07-01T23:59:59.000Z

425

Photochemical Escape of Oxygen from Early Mars  

E-Print Network [OSTI]

Photochemical escape is an important process for oxygen escape from present Mars. In this work, a 1-D Monte-Carlo Model is developed to calculate escape rates of energetic oxygen atoms produced from O2+ dissociative recombination reactions (DR) under 1, 3, 10, and 20 times present solar XUV fluxes. We found that although the overall DR rates increase with solar XUV flux almost linearly, oxygen escape rate increases from 1 to 10 times present solar XUV conditions but decreases when increasing solar XUV flux further. Analysis shows that atomic species in the upper thermosphere of early Mars increases more rapidly than O2+ when increasing XUV fluxes. While the latter is the source of energetic O atoms, the former increases the collision probability and thus decreases the escape probability of energetic O. Our results suggest that photochemical escape be a less important escape mechanism than previously thought for the loss of water and/or CO2 from early Mars.

Zhao, Jinjin

2015-01-01T23:59:59.000Z

426

Prevalence, genetic diversity and antiretroviral drugs resistance-associated mutations among untreated HIV-1-infected pregnant women in Gabon, central Africa  

Science Journals Connector (OSTI)

To determine the prevalence of antibodies to HIV among a high-risk population in Gabon, 1098 and 2916 samples were collected from...

Mélanie Caron; Sonia Etenna Lekana-Douki; Maria Makuwa…

2012-03-01T23:59:59.000Z

427

Restructuring and aging in a capillary suspension  

E-Print Network [OSTI]

The rheological properties of capillary suspensions, suspensions with small amounts of an added immiscible fluid, are dramatically altered with the addition of the secondary fluid. We investigate a capillary suspension to determine how the network ages and restructures at rest and under applied external shear deformation. The present work uses calcium carbonate suspended in silicone oil (11 % solids) with added water as a model system. Aging of capillary suspensions and their response to applied oscillatory shear is distinctly different from particulate gels dominated by the van der Waals forces. The suspensions dominated by the capillary force are very sensitive to oscillatory flow, with the linear viscoelastic regime ending at a deformation of only 0.1 % and demonstrating power-law aging behavior. This aging persists for long times at low deformations or for shorter times with a sudden decrease in the strength at higher deformations. This aging behavior suggests that the network is able to rearrange and even rupture. This same sensitivity is not demonstrated in shear flow where very high shear rates are required to rupture the agglomerates returning the apparent viscosity of capillary suspensions to the same viscosity as for the pure vdW suspension. A transitional region is also present at intermediate water contents wherein the material response depends very strongly on the type, strength, and duration of the external forcing.

Erin Koos; Wolfgang Kannowade; Norbert Willenbacher

2014-10-16T23:59:59.000Z

428

Anticlericalism and the Early Tudor Parliament  

E-Print Network [OSTI]

1 Anticlericalism and the Early Tudor Parliament? P.R. CAVILL Pembroke College, Cambridge This essay reconsiders one aspect of Christopher Haigh’s influential article ‘Anticlericalism and the English Reformation’. The article argued... in the governmental archive need not imply royal initiative: a petition about tithes in Romney Marsh, for instance, originated locally.36 Although the editors of Letters and Papers linked the bill to a complaint from Londoners against other oblations demanded...

Cavill, P. R.

2014-01-01T23:59:59.000Z

429

Early Standard Model measurements with ATLAS  

E-Print Network [OSTI]

The measurement of Standard Model processes will be an important first step towards exploiting the discovery potential of the Large Hadron Collider, the highest energy accelerator ever built that will begin operation in the fall 2009. This paper presents a summary of the early physics analyses for understanding the performance of the detector as well as the Standard Model at the ATLAS experiment at 14 TeV centre of mass energy.

T. Ince; for the ATLAS collaboration

2009-05-28T23:59:59.000Z

430

Early B-physics at ATLAS  

E-Print Network [OSTI]

The B-physics program at the ATLAS experiment, which covers the mid-rapidity region, complements that at the dedicated LHCb experiment, which covers the forward rapidity region. At the early stage of the LHC operation, the program concentrated on understanding of detector performance and measurements of quarkonia and D mesons. This article presents recent results of the B-physics program at ATLAS.

S. Oda; on behalf of the ATLAS Collaboration

2010-10-18T23:59:59.000Z

431

Black hole remnants in the early universe  

Science Journals Connector (OSTI)

We consider the production of primordial micro black holes (MBH) remnants in the early Universe. These objects induce the Universe to be in a matter-dominated era before the onset of inflation. Effects of such an epoch on the CMB power spectrum are discussed and computed both analytically and numerically. By comparison with the latest observational data from the WMAP collaboration, we find that our model appears to explain the quadrupole anomaly of the CMB power spectrum.

Fabio Scardigli; Christine Gruber; Pisin Chen

2011-03-09T23:59:59.000Z

432

Earth: The Early Years We discuss ...  

E-Print Network [OSTI]

): 3.5 b.y Oldest rock (gneiss; Slave, N. Canada): 3.96 b.y Oldest mineral (zircon; NW Australia): 4 (Ga), which dates beginning of our solar system. · This contrasts with the age of ~14 Ga for our Universe, meaning that we occupy a recent solar system. · The atoms on and in Earth (incl. life) are mostly

433

Property:VolcanicAge | Open Energy Information  

Open Energy Info (EERE)

Property Property Edit with form History Facebook icon Twitter icon » Property:VolcanicAge Jump to: navigation, search Property Name VolcanicAge Property Type String Description Describes the time of the most recent volcanism by epoch, era, or period per available data. Subproperties This property has the following 7 subproperties: E East Mesa Geothermal Area G Geysers Geothermal Area L Lightning Dock Geothermal Area R Raft River Geothermal Area Roosevelt Hot Springs Geothermal Area S Salton Sea Geothermal Area Soda Lake Geothermal Area Pages using the property "VolcanicAge" Showing 19 pages using this property. A Amedee Geothermal Area + No volcanism + B Beowawe Hot Springs Geothermal Area + no volcanism + Blue Mountain Geothermal Area + no volcanism + Brady Hot Springs Geothermal Area + No volcanism +

434

Personalized Translation Listening System for Age Groups  

Science Journals Connector (OSTI)

Present translation systems play back their results with specific speed and volume regardless of the type of user. In this paper, we describe a personalized translation listening system by identifying user information. User groups are classified by age group after inputting speech. This suggested translation system gives the translated result back to the user, speaking at an emphasized speech based on the user's age. The personalized translation listening system performs age recognition, speech recognition, language recognition, Google machine translation, and TTS web services. We showed the comparison of normal speech and emphasized speech by realizing a user-oriented translation system in a mobile device. A Mean Opinion Score was used for the experiment. Average score of the Mean Opinion Score experiment was 3.21.

Do-won Jang; Dong-Ju Kim; Kwang-Seok Hong

2011-01-01T23:59:59.000Z

435

Effective temperature of an aging powder  

Science Journals Connector (OSTI)

The aging dynamics and the fluctuation-dissipation relation between the spontaneous diffusion induced by a random noise and the drift motion induced by a small stirring force are numerically investigated in a 3D schematic model of compacting powder: a gravity-driven lattice-gas with purely kinetic constraints. The compaction dynamics is characterized by a super-aging behavior and, in analogy with glasses, exhibits a purely dynamical time-scale-dependent effective temperature. A simple experiment to measure this quantity is suggested.

Mauro Sellitto

2001-05-11T23:59:59.000Z

436

Died suddenly under age 50 Heart disease  

E-Print Network [OSTI]

­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­­ _____________________________________________________________ Student cell phone Current email address (for contact over the summer) Persons to contact in case _________________________________________________ _________________________________________________ Home phone Business phone Cell phone Home phone Business phone Cell phone State of Age at Age Health _________________________________________________ _________________________________________________ City State Zip Code Nation (if not US) Home phone

Smith, Marc L.

437

Aging assessment for active fire protection systems  

SciTech Connect (OSTI)

This study assessed the impact of aging on the performance and reliability of active fire protection systems including both fixed fire suppression and fixed fire detection systems. The experience base shows that most nuclear power plants have an aggressive maintenance and testing program and are finding degraded fire protection system components before a failure occurs. Also, from the data reviewed it is clear that the risk impact of fire protection system aging is low. However, it is assumed that a more aggressive maintenance and testing program involving preventive diagnostics may reduce the risk impact even further.

Ross, S.B. [Science and Engineering Associates, Inc. (United States); Nowlen, S.P.; Tanaka, T. [Sandia National Labs., Albuquerque, NM (United States)

1995-06-01T23:59:59.000Z

438

Opportunities for the Early Production of Fischer-Tropsch (F...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

for the Early Production of Fischer-Tropsch (F-T) Fuels in the U.S. -- An Overview Opportunities for the Early Production of Fischer-Tropsch (F-T) Fuels in the U.S. -- An Overview...

439

EWAS: Modeling Application for Early Detection of Terrorist Threats  

Science Journals Connector (OSTI)

This paper presents a model and system architecture for an early warning system to detect terrorist threats. The paper discusses the shortcomings of state ... of generation of early warnings to predict terrorist

Pir Abdul Rasool Qureshi; Nasrullah Memon…

2010-01-01T23:59:59.000Z

440

White House Honors Four Early-Career Sandia Researchers | National...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Photo Gallery Jobs Apply for Our Jobs Our Jobs Working at NNSA Blog Home NNSA Blog White House Honors Four Early-Career Sandia Researchers White House Honors Four Early-Career...

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Designing CPV Receivers With Reliability: Early Evaluation of Components  

E-Print Network [OSTI]

. Everett, A. Blakers Centre for Sustainable Energy Systems, The Australian National University, Canberra: Early detection of performance issues allows more rapid & reliable design optimisation. Thermal. Ultra light-weight Fresnel mirror enclosed system. DESIGN RELIABILITY PRODUCTION Early detection

442

Accelerated Aging of Roofing Materials - 2013 BTO Peer Review...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Accelerated Aging of Roofing Materials - 2013 BTO Peer Review Accelerated Aging of Roofing Materials - 2013 BTO Peer Review Emerging Technologies Project for the 2013 Building...

443

Review: Glut: Mastering Information throughout the Ages by Alex Wright  

E-Print Network [OSTI]

In positing his proposal, Wright has provided the literaturethrough the Ages by Alex Wright. Washington: Joseph Henrythrough the Ages, Alex Wright may have uncovered one such

Haley, Dan

2008-01-01T23:59:59.000Z

444

Nuclear Matrix protein SMAR1 represses HIV-1 LTR mediated transcription through chromatin remodeling  

SciTech Connect (OSTI)

Nuclear Matrix and MARs have been implicated in the transcriptional regulation of host as well as viral genes but their precise role in HIV-1 transcription remains unclear. Here, we show that > 98% of HIV sequences contain consensus MAR element in their promoter. We show that SMAR1 binds to the LTR MAR and reinforces transcriptional silencing by tethering the LTR MAR to nuclear matrix. SMAR1 associated HDAC1-mSin3 corepressor complex is dislodged from the LTR upon cellular activation by PMA/TNFalpha leading to an increase in the acetylation and a reduction in the trimethylation of histones, associated with the recruitment of RNA Polymerase II on the LTR. Overexpression of SMAR1 lead to reduction in LTR mediated transcription, both in a Tat dependent and independent manner, resulting in a decreased virion production. These results demonstrate the role of SMAR1 in regulating viral transcription by alternative compartmentalization of LTR between the nuclear matrix and chromatin.

Sreenath, Kadreppa; Pavithra, Lakshminarasimhan; Singh, Sandeep; Sinha, Surajit [National Centre for Cell science, University of Pune Campus, Ganeshkhind, Pune 411007, Maharashtra (India); Dash, Prasanta K.; Siddappa, Nagadenahalli B.; Ranga, Udaykumar [Molecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore (India); Mitra, Debashis [National Centre for Cell science, University of Pune Campus, Ganeshkhind, Pune 411007, Maharashtra (India); Chattopadhyay, Samit, E-mail: samit@nccs.res.i [National Centre for Cell science, University of Pune Campus, Ganeshkhind, Pune 411007, Maharashtra (India)

2010-04-25T23:59:59.000Z

445

Protein conformational dynamics in the mechanism of HIV-1 protease catalysis  

SciTech Connect (OSTI)

We have used chemical protein synthesis and advanced physical methods to probe dynamics-function correlations for the HIV-1 protease, an enzyme that has received considerable attention as a target for the treatment of AIDS. Chemical synthesis was used to prepare a series of unique analogues of the HIV-1 protease in which the flexibility of the 'flap' structures (residues 37-61 in each monomer of the homodimeric protein molecule) was systematically varied. These analogue enzymes were further studied by X-ray crystallography, NMR relaxation, and pulse-EPR methods, in conjunction with molecular dynamics simulations. We show that conformational isomerization in the flaps is correlated with structural reorganization of residues in the active site, and that it is preorganization of the active site that is a rate-limiting factor in catalysis.

Torbeev, Vladimir Yu.; Raghuraman, H.; Hamelberg, Donald; Tonelli, Marco; Westler, William M.; Perozo, Eduardo; Kent, Stephen B.H. (GSU); (UW); (UC)

2013-09-17T23:59:59.000Z

446

Effect of non-ageing and ageing ceria nanoparticles suspensions on fresh water micro-algae  

E-Print Network [OSTI]

Effect of non-ageing and ageing ceria nanoparticles suspensions on fresh water micro-algae Manier nanoparticle (nCeO2) suspensions, towards freshwater micro-algae assessing the effect nCeO2 suspensions microscopy (TEM). In addition, the interaction between NPs and algae were investigated using flow

Boyer, Edmond

447

Structural and Functional Studies of the Receptor-binding and Glycosaminogly-canbinding Mechanisms of a Viral Chemokine Analog vMIP-II and Rational Design of Chemokine-based Highly Potent HIV-1 Entry Inhibitors  

E-Print Network [OSTI]

............................................................................................... 82 Table 4.1 Anti-HIV activities of the chimeric inhibitors in R5 cell-cell fusion assay ................................................................................................... 102 Table 4.2 Anti-HIV activities of the chimeric... assay ......... 106 Table 4.6 Anti-HIV activities of the chimeric inhibitors in X4 cell-cell fusion assay ................................................................................................... 106 Table 4.7 Anti-HIV activities of 5P...

Zhao, Bo

2012-07-16T23:59:59.000Z

448

Economic Impacts of Early Care and Education in California  

E-Print Network [OSTI]

Economic Impacts of Early Care and Education in California by Jenifer MacGillvary and Laurel Lucia August 2011 #12;#12;Economic Impacts of Early Care and Education in California by Jenifer Mac Siciliano 2 | Economic Impacts of Early Care and Education in California #12;Jenifer MacGillvary and Laurel

Militzer, Burkhard

449

Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse  

Science Journals Connector (OSTI)

HIV-Tat protein has been implicated in the pathogenesis of HIV-1 neurological complications (i.e., neuroAIDS), but direct demonstrations of the effects of Tat on behavior are limited. GT-tg mice with a doxycycline (Dox)-inducible and brain-selective tat gene coding for Tat protein were used to test the hypothesis that the activity of Tat in brain is sufficient to impair learning and memory processes. Western blot analysis of GT-tg mouse brains demonstrated an increase in Tat antibody labeling that seemed to be dependent on the dose and duration of Dox pretreatment. Dox-treated GT-tg mice tested in the Barnes maze demonstrated longer latencies to find an escape hole and displayed deficits in probe trial performance versus uninduced GT-tg littermates, suggesting Tat-induced impairments of spatial learning and memory. Reversal learning was also impaired in Tat-induced mice. Tat-induced mice additionally demonstrated long-lasting (up to one month) deficiencies in novel object recognition learning and memory performance. Furthermore, novel object recognition impairment was dependent on the dose and duration of Dox exposure, suggesting that Tat exposure progressively mediated deficits. These experiments provide evidence that Tat protein expression is sufficient to mediate cognitive abnormalities seen in HIV-infected individuals. Moreover, the genetically engineered GT-tg mouse may be useful for improving our understanding of the neurological underpinnings of neuroAIDS-related behaviors.

Amanda N. Carey; Elizabeth I. Sypek; Harminder D. Singh; Marc J. Kaufman; Jay P. McLaughlin

2012-01-01T23:59:59.000Z

450

Transient-mediated fate determination in a transcriptional circuit of HIV  

SciTech Connect (OSTI)

Steady-state behavior and bistability have been proposed as mechanisms for decision-making in gene circuits1-3. However, transient gene expression has also been proposed to control cell fate4, 5 with the decision arbitrated by the lifetime of the expression transient. Here, we report that transcriptional positive-feedback plays a critical role in determining HIV infected cell-fate by extending the duration of Tat expression transients6, 7 far beyond what protein half-life modulation can achieve. To directly quantify feedback strength and its effects on the duration of Tat transcriptional pulses, we exploit the noise inherent to gene-expression and measure shifts in the autocorrelation of expression noise. The results indicate that transcriptional positive-feedback extends the single-cell Tat expression lifetime by 2-to 6-fold for both minimal Tat circuits and full-length, actively-replicating HIV-1. Importantly, artificial weakening of Tat positive-feedback shortened the duration of Tat expression transients and biased the probability in favor of latency. Thus, transcriptional positive-feedback appears to modulate transient expression lifetime and thereby control cell-fate in HIV.

Weinberger, Leor S. [University of California, San Diego; Dar, Roy D. [University of Tennessee, Knoxville (UTK); Simpson, Michael L [ORNL

2008-01-01T23:59:59.000Z

451

Aging assessment of auxiliary feedwater systems  

SciTech Connect (OSTI)

A study of Pressurized Water Reactor Auxiliary Feedwater (AFW) Systems has been conducted by Oak Ridge National Laboratory (ORNL) under the auspices of the Nuclear Regulatory Commission's Nuclear Plant Aging Research Program. The study has reviewed historical failure experience and current monitoring practices for the AFW System. This paper provides an overview of the study approach and results. 7 figs.

Casada, D.A. (Oak Ridge National Lab., TN (USA))

1989-01-01T23:59:59.000Z

452

Eligibility: Cancer Survivor ages 35-75  

E-Print Network [OSTI]

Eligibility: · Cancer Survivor ages 35-75 · Patient has completed treatment within last two years for non-metastic solid tumor · Patient's cancer is currently considered stable or in remission · At least. Please contact Missy Buchanan 415-353-7019 for more information. Helen Diller Family Comprehensive Cancer

Walter, Peter

453

Thermal aging of nitroplasticized Estane 5703  

SciTech Connect (OSTI)

In support of the Lifetime Prediction modeling effort, we have been investigating the aging processes that could impact the lifetime of PBX 9501. PBX 9501 is composed of 95% HMX and 5% polymeric binder. The polymeric binder is composed of 50% nitroplasticizer (NP) and 50% Estane{reg_sign} 5703 with a small quantity of stabilizer. Estane{reg_sign} 5703 is a segmented poly(ester urethane) with mechanical properties derived from phase separation of hard and soft segments along the polymer backbone. Since the binder has a significant effect on the composite mechanical properties, it is essential to know how the binder changes with time. Typically, polymer lifetime predictions are determined from extrapolation of properties after the material has been exposed to elevated temperatures and/or reactive environments for varying periods of time. For multiphase polymers, this accelerated aging methodology is very difficult to interpret since elevated temperatures alter the physical structure of the polymer, as well as, accelerate the chemical degradation reactions. Accelerated aging studies of nitroplasticized Estane have shown an increase in the molecular weight. The increase in molecular weight is most likely due to polymer chain branching reactions that eventually leads to formation an insoluble cross-linked gel. The decreased chain mobility caused by branching may also affect phase separation, which in turn, may change the mechanical properties. In this paper we report results of thermal aging studies on the properties, morphology and chemistry of nitroplasticized Estane.

Orler, E. B. (E. Bruce); Wrobleski, Debra A.; Cooke, D. W. (D. Wayne); Bennett, B. L. (Bryan L.); Smith, M. E. (Mark E.); Jahan, M. S. (M. Shan)

2002-01-01T23:59:59.000Z

454

Evolution of cardiorespiratory interactions with age  

Science Journals Connector (OSTI)

...ac.uk 1 Department of Physics, Lancaster University...modulations of the heart rate both decrease with age...associated physiology and physics have been under continuing...focused mainly on the heart rate variability (HRV) that...IHF is obtained by low-pass filtering, spline interpolation...

2013-01-01T23:59:59.000Z

455

7, 1365313697, 2007 Global mean age of  

E-Print Network [OSTI]

ACPD 7, 13653­13697, 2007 Global mean age of air from MIPAS G. P. Stiller et al. Title Page measurements G. P. Stiller 1 , T. von Clarmann 1 , M. H¨opfner 1 , N. Glatthor 1 , U. Grabowski 1 , S. Kellmann Correspondence to: G. P. Stiller (gabriele.stiller@imk.fzk.de) 13653 #12;ACPD 7, 13653­13697, 2007 Global mean

Paris-Sud XI, Université de

456

Economic and social implications of aging societies  

Science Journals Connector (OSTI)

...welfare. Immigration can affect the sustainability gap of public finances as it increases the number...relative to working-age adults. All three factors are likely to change as the...broad, coherent, and integrated multi-pillar approaches to labor markets, health...

Sarah Harper

2014-10-31T23:59:59.000Z

457

Electronic games for aged care and rehabilitation  

Science Journals Connector (OSTI)

The declining cognitive and motor abilities has become a major problem in the health care of the elderly, often leading to potentially fatal falls. Current rehabilitation strategies to address this issue include routine physiotherapy which is often dull ... Keywords: aged care, rehabilitation, software agent, video game

Stuart T. Smith; Amir Talaei-Khoei; Mililani Ray; Pradeep Ray

2009-12-01T23:59:59.000Z

458

Characterizing mechanical effects of aging damage  

SciTech Connect (OSTI)

This is the final report of a two-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The goal was to develop and apply several different experimental and theoretical/computational tools to better understand physical and chemical aging phenomena in plastic-bonded high explosives, and to develop a methodology for predicting the likely effects of aging on the mechanical properties of the composite based on input from these fundamental studies. Initial comparisons were done for spectra of fresh and aged Esane, as well as PBX-9501, and the authors found differences in the carbonyl region of the spectrum, which possibly reflect differences in hydrogen bonding due to aging phenomena. The micromechanical model of composites was extended to study various volume fractions of HMX with binders. The results showed that, as the binder fraction increases, there is a decrease in the maximum stress that can be supported but an increase in the percent strain at final fracture. A more realistic microstructural model was obtained through the use of a phase field model. Using this model, the authors have studied the microstructural evolution as a function of the grain boundary energy vs. misorientation relationship. The initial results indicate that there are some changes in the grain growth rate when the grain-boundary energy dependence on the angle is not constant. They also find that solute tends to segregate at the grain boundary and slows the grain growth kinetics.

Sewell, T.D.; Chen, S.P.; Schoonover, J.R.; Trent, B.C.; Howe, P.M.; Hjelm, R.P.; Browning, R.V.

1998-12-01T23:59:59.000Z

459

Stone Age Distributed Computing (Extended Abstract)  

E-Print Network [OSTI]

on the first page. Copyrights for components of this work owned by others than ACM must be honored. AbstractingStone Age Distributed Computing (Extended Abstract) Yuval Emek Distributed Computing Group ETH wattenhofer@ethz.ch ABSTRACT A new model that depicts a network of randomized finite state machines operating

460

Deactivation of Accelerated Engine-Aged and Field-Aged SCR Catalysts and the Role of the DOC  

Broader source: Energy.gov [DOE]

A technique for accelerated aging of SCR system (DOC -> SCR-> DPF) reveals two deactivation mechanisms and replicates field-aged effects

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
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to obtain the most current and comprehensive results.


461

Those early days as we remember them (part I) - Met Lab and Argonne's Early  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

History >Those early days as we remember them (Part I) History >Those early days as we remember them (Part I) About Director's Welcome Organization Achievements Highlights Fact Sheets, Brochures & Other Documents Multimedia Library Visit Argonne Work with Argonne Contact us Nuclear Energy Why Nuclear Energy? Why are some people afraid of Nuclear Energy? How do nuclear reactors work? Cheaper & Safer Nuclear Energy Helping to Solve the Nuclear Waste Problem Nuclear Reactors Nuclear Reactors Early Exploration Training Reactors Basic and Applied Science Research LWR Technology Development BORAX-III lighting Arco, Idaho (Press Release) Heavy Water and Graphite Reactors Fast Reactor Technology Integral Fast Reactor Argonne Reactor Tree CP-1 70th Anniversary CP-1 70th Anniversary Argonne's Nuclear Science and Technology Legacy

462

Those early days as we remember them - Met Lab and Argonne's Early History  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

and Early and Early History About Director's Welcome Organization Achievements Highlights Fact Sheets, Brochures & Other Documents Multimedia Library Visit Argonne Work with Argonne Contact us Nuclear Energy Why Nuclear Energy? Why are some people afraid of Nuclear Energy? How do nuclear reactors work? Cheaper & Safer Nuclear Energy Helping to Solve the Nuclear Waste Problem Nuclear Reactors Nuclear Reactors Early Exploration Training Reactors Basic and Applied Science Research LWR Technology Development BORAX-III lighting Arco, Idaho (Press Release) Heavy Water and Graphite Reactors Fast Reactor Technology Integral Fast Reactor Argonne Reactor Tree CP-1 70th Anniversary CP-1 70th Anniversary Argonne's Nuclear Science and Technology Legacy Argonne's Nuclear Science and Technology Legacy

463

HIV-1 Tat Protein Induces PD-L1 (B7-H1) Expression on Dendritic Cells through Tumor Necrosis Factor Alpha- and Toll-Like Receptor 4-Mediated Mechanisms  

Science Journals Connector (OSTI)

...research-article Pathogenesis and Immunity HIV-1 Tat Protein Induces PD-L1 (B7-H1...was to determine whether and how HIV-1 Tat protein, an immunosuppressive viral...that treatment of DCs with whole HIV-1 Tat protein significantly upregulated...

Rémi Plančs; Lbachir BenMohamed; Kaoutar Leghmari; Pierre Delobel; Jacques Izopet; Elmostafa Bahraoui

2014-04-02T23:59:59.000Z

464

Nucleosynthesis in Early Neutrino Driven Winds  

SciTech Connect (OSTI)

Two recent issues related to nucleosynthesis in early proton-rich neutrino winds are investigated. In the first part we investigate the effect of nuclear physics uncertainties on the synthesis of {sup 92}Mo and {sup 94}Mo. Based on recent experimental results, we find that the proton rich winds of the model investigated here can not be the only source of the solar abundance of {sup 92}Mo and {sup 94}Mo. In the second part we investigate the nucleosynthesis from neutron rich bubbles and show that they do not contribute to the nucleosynthesis integrated over both neutron and proton-rich bubbles and proton-rich winds.

Hoffman, R; Fisker, J; Pruet, J; Woosley, S; Janka, H; Buras, R

2008-01-09T23:59:59.000Z

465

Nucleosynthesis in Early Neutrino Driven Winds  

SciTech Connect (OSTI)

Two recent issues realted to nucleosynthesis in early proton-rich neutrino winds are investigated. In the first part we investigate the effect of nuclear physics uncertainties on the synthesis of {sup 92}Mo and {sup 94}Mo. Based on recent experimental results, we find that the proton rich winds of the model investigated here can not be the only source of the solar abundance of {sup 92}Mo and {sup 94}Mo. In the second part we investigate the nucleosynthesis from neutron rich bubbles and show that they do not contribute to the nucleosynthesis integrated over both neutron and proton-rich bubbles and proton-rich winds.

Hoffman, R. D.; Fisker, J. L. [Lawrence Livermore National Laboratory, PO Box 808, L-414, Livermore, CA 94550 (United States); Pruet, J. [Lawrence Livermore National Laboratory, PO Box 808, L-059, Livermore, CA 94550 (United States); Woosley, S. E. [Department of Astronomy and Astrophysics, UC Santa Cruz, Santa Cruz, CA 95064 (United States); Janka, H.-T.; Buras, R. [Max Plank Institute for Astrophysics, Karl-Schwarzschild-Str. 1, 85741 Garching (Germany)

2008-04-17T23:59:59.000Z

466

Emergence of Broadly Neutralizing Antibodies and Viral Coevolution in Two Subjects during the Early Stages of Infection with Human Immunodeficiency Virus Type 1  

Science Journals Connector (OSTI)

...Primate Research Center, Oregon Health Science University, Beaverton, Oregon, USA...and PG16 were obtained from Theraclone Sciences (Seattle, WA, USA). HIV-1/HIV-2...recombinant human monoclonal antibody. Science 266 :1024-1027. doi: 10.1126...

D. Noah Sather; Sara Carbonetti; Delphine C. Malherbe; Franco Pissani; Andrew B. Stuart; Ann J. Hessell; Mathew D. Gray; Iliyana Mikell; Spyros A. Kalams; Nancy L. Haigwood; Leonidas Stamatatos

2014-08-13T23:59:59.000Z

467

Fuel Cell Technologies Office: Early Market Applications for Fuel Cell  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Market Transformation Market Transformation Printable Version Share this resource Send a link to Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies to someone by E-mail Share Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Facebook Tweet about Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Twitter Bookmark Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Google Bookmark Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Delicious Rank Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Digg Find More places to share Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on AddThis.com...

468

Extracellular HIV-1 Tat induces human beta-defensin-2 production via NF-kappaB/AP-1 dependent pathways in human B cells  

Science Journals Connector (OSTI)

Defensins, a family of antimicrobial peptides, are one of the first lines of host defense. Human beta-defensins (hBD) such as hBD-2 and -3 have anti-HIV activity. Previous studies have shown that HIV-1 virion can...

Sung Mi Ju; Ah Ra Goh; Dong-Joo Kwon; Gi Soo Youn; Hyung-Joo Kwon…

2012-04-01T23:59:59.000Z

469

Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors  

Science Journals Connector (OSTI)

...sequence, to trigger and drive the development of naive...antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine...Distance-scaled, finite ideal-gas reference state improves...be used to trigger and drive the development of memory...

Mattia Bonsignori; Kwan-Ki Hwang; Xi Chen; Chun-Yen Tsao; Lynn Morris; Elin Gray; Dawn J. Marshall; John A. Crump; Saidi H. Kapiga; Noel E. Sam; Faruk Sinangil; Marie Pancera; Yang Yongping; Baoshan Zhang; Jiang Zhu; Peter D. Kwong; Sijy O'Dell; John R. Mascola; Lan Wu; Gary J. Nabel; Sanjay Phogat; Michael S. Seaman; John F. Whitesides; M. Anthony Moody; Garnett Kelsoe; Xinzhen Yang; Joseph Sodroski; George M. Shaw; David C. Montefiori; Thomas B. Kepler; Georgia D. Tomaras; S. Munir Alam; Hua-Xin Liao; Barton F. Haynes

2011-07-27T23:59:59.000Z

470

Welcome to Early Science Program Investigators Meeting  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Early Science Program Early Science Program Investigators Meeting Timothy J . W illiams Argonne L eadership C ompu2ng F acility 2 At Argonne, Safety is First! § In c ase o f a n e mergency o r i njury, d ial 9 11 f rom t he building p hones, o r d ial 6 30---252---1911 f rom c ell p hones. § Fire: A lways b e a ware o f t he n earest e xit. - If t he b uilding a larms s ound, e vacuate t he b uilding a nd p roceed t o the r eloca9on a rea ( building 2 13). - If a s ite---wide a larm s ounds, f ollow t he d irec9ons i ssued o ver t he public a nnouncement s ystem. § Tornado: I n t he e vent o f a t ornado, a t one a nd announcement will come from the public announcement s ystem. S eek s helter i mmediately i n t he nearest s tairwell. § Smoking i n n ot p ermiLed i n b uilding 2 40. S moking i s permiLed o nly i n t he d esignated

471

HIV-1 Tat neurotoxicity: A model of acute and chronic exposure, and neuroprotection by gene delivery of antioxidant enzymes  

Science Journals Connector (OSTI)

HIV-associated neurocognitive disorder (HAND) is an increasingly common, progressive disease characterized by neuronal loss and progressively deteriorating CNS function. HIV-1 gene products, particularly gp120 and Tat elicit reactive oxygen species (ROS) that lead to oxidant injury and cause neuron apoptosis. Understanding of, and developing therapies for, HAND requires accessible models of the disease. We have devised experimental approaches to studying the acute and chronic effects of Tat on the CNS. We studied acute exposure by injecting recombinant Tat protein into the caudate-putamen (CP). Ongoing Tat expression, which more closely mimics HIV-1 infection of the brain, was studied by delivering Tat-expression over time using an SV40-derived gene delivery vector, SV(Tat). Both acute and chronic Tat exposure induced lipid peroxidation and neuronal apoptosis. Finally, prior administration of recombinant SV40 vectors carrying antioxidant enzymes, copper/zinc superoxide dismutase (SOD1) or glutathione peroxidase (GPx1), protected from Tat-induced apoptosis and oxidative injury. Thus, injection of recombinant HIV-1 Tat and the expression vector, SV(Tat), into the rat CP cause respectively acute or ongoing apoptosis and oxidative stress in neurons and may represent useful animal models for studying the pathogenesis and, potentially, treatment of HIV-1 Tat-related damage.

Lokesh Agrawal; Jean-Pierre Louboutin; Beverly A.S. Reyes; Elisabeth J. Van Bockstaele; David S. Strayer

2012-01-01T23:59:59.000Z

472

Age of Goose Rock Conglomerate, Wheele and Grant Counties, north-central Oregon  

SciTech Connect (OSTI)

A reconstruction of the geologic history and synthesis of the tectonic history of the Blue Mountains and Columbia Basin require that they know the age of key outcrops. The geological record in this entire area has been largely hidden by a thick blanket of Tertiary volcanic rocks. Only a few erosional inliers are available from which to interpret the pre-volcanic tectonic and sedimentation history. The Goose Rock Inlier, exposed along the John Day River in the Butler basin and Turtle Cove, is one such important outcrop. These exposures, consisting of a few hundred feet of fluvial sandstones and conglomerates, informally called the Goose Rock Conglomerate have received only limited attention from previous workers. Estimates of this unit's age range from Early Cretaceous to early Tertiary, on the basis of lithologic similarities with other named and unnamed formations in the area. The terrestrial nature of these strata and the apparent lack of fossils cause considerable difficulty in correlation with other Cretaceous sequences, which are largely marine. In the absence of scarcity of other fossils, palynology offers a unique alternative for making biochronological and paleoenvironmental interpretations.

Aguirre, M.R.; Fisk, L.H.

1987-08-01T23:59:59.000Z

473

THE INTERACTING EARLY-TYPE BINARY V382 Cyg  

SciTech Connect (OSTI)

We analyze photometric and spectroscopic data and study the orbital period of the early-type interacting binary system V382 Cyg by using all the available data. We obtain a simultaneous light and radial velocity curve solution. The derived physical parameters of the primary and secondary stellar components are M{sub 1} = 27.9(5) M{sub Sun }, M{sub 2} = 20.8(4) M{sub Sun }, R{sub 1} = 9.7(2) R{sub Sun }, R{sub 2} = 8.5(2) R{sub Sun }, log ({sub 1}/L{sub Sun }) = 5.152(20), and log (L{sub 2}/L{sub Sun }) = 4.954(19) while the separation of the components is a = 23.4 R{sub Sun }. Newly obtained parameters yield the distance of the system to be 1466(76) pc. Analyses of the mid-eclipse times indicate a period increase of dP/dt = 4.2(1) Multiplication-Sign 10{sup -7} days yr{sup -1} that can be interpreted in terms of the high-mass transfer (dM/dt 6.1(5) Multiplication-Sign 10{sup -6} M{sub Sun} yr{sup -1}) from the less massive component to the more massive component. Finally, we model the evolution of the components using non-conservative codes and discuss the results obtained. The age of the binary system is estimated to be 3.85 Myr.

Yasarsoy, B.; Yakut, K. [Department of Astronomy and Space Sciences, University of Ege, 35100 Bornova-Izmir (Turkey)

2013-01-01T23:59:59.000Z

474

Managing Aging Effects on Dry Cask Storage  

Broader source: Energy.gov (indexed) [DOE]

Managing Aging Effects Managing Aging Effects on Dry Cask Storage Systems for Extended Long-Term Storage and Transportation of Used Fuel Rev. 0 Prepared for U.S. Department of Energy Used Fuel Disposition Campaign O.K. Chopra, D. Diercks, R. Fabian, D. Ma, V. Shah, S-W Tam, and Y.Y. Liu Argonne National Laboratory June 30, 2012 FCRD-USED-2012-000119 ANL-12/29 DISCLAIMER This information was prepared as an account of work sponsored by an agency of the U.S. Government. Neither the U.S. Government nor any agency thereof, nor any of their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness, of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately

475

Accelerated aging of EPDM and butyl elastomers  

SciTech Connect (OSTI)

This study was composed of three parts: a post cure study to optimize final properties of an ethylene-propylene-diene (EPDM) formulation, an accelerated aging study to compare the stress relaxation behavior of a butyl and an EPDM elastomer under compression, and a cursory evaluation of a new 70 Shore A EPDM. The optimum postcure for the EPDM was found to be 2 to 4 hours at 182{degrees}C in a vacuum. The EPDM was also shown to have superior aging characteristics compared to the butyl and is recommended for use instead of the butyl material. The physical properties for new 70 Shore A EPDM are satisfactory, and the stress relaxation behavior was only slightly inferior to the other EPDM.

Wilson, M.H.

1996-06-01T23:59:59.000Z

476

Continuous Commissioning® in an Aged Office Building  

E-Print Network [OSTI]

ICEBO2005 Cui and Liu Continuous Commissioning SM in an Aged Office Building Y. Cui, Ph.D. Energy Systems Laboratory Architectural Engineering Department University of Nebraska-Lincoln Omaha, NE 68182 cuiy@unomaha.edu Mingsheng Liu, Ph... and Liu Units (AHUs). Among these, 7 AHUs serve the Main Building and Executive Wing areas: one AHU, called Primary AHU, for the perimeter of the Main Building and Executive Wing areas, and six AHUs, called Interior AHUs, for the interior of Main...

Cui, Y.; Liu, M.

2005-01-01T23:59:59.000Z

477

Deactivation of Accelerated Engine-Aged and Field-Aged Fe-Zeolite SCR Catalysts  

SciTech Connect (OSTI)

A single-cylinder diesel engine with an emissions control system - diesel oxidation catalyst (DOC), Fe-zeolite selective catalytic reduction (SCR) catalyst, and diesel particulate filter (DPF) - was used to perform accelerated thermal aging of the SCR catalyst. Cyclic aging is performed at SCR inlet temperatures of 650, 750 and 850 degrees C for up to 50 aging cycles. To assess the validity of the implemented accelerated thermal aging protocol, a field-aged SCR catalyst of similar formulation was also evaluated. The monoliths were cut into sections and evaluated for NO{sub x} performance in a bench-flow reactor. While the rear section of both the field-aged and the accelerated engine-aged SCR catalysts maintained high NO{sub x}conversion, 75-80% at 400 degrees C, the front section exhibited a drastic decrease to only 20-35% at 400 degrees C. This two-tiered deactivation was also observed for field-aged samples that were analyzed in this study. To understand the observed performance changes, thorough materials characterization was performed which revealed two primary degradation mechanisms. The first mechanism is a general Fe-zeolite deterioration which led to surface area losses, dealumination of the zeolite, and Fe{sub 2}O{sub 3} crystal growth. This degradation accelerated above 750 degrees C, and the effects were generally more severe in the front of the catalyst. The second deactivation mechanism is linked to trace levels of Pt that are suspected to be volatizing from the DOC and depositing on the front section of the SCR catalyst. Chemical evidence of this can be seen in the high levels of NH{sub 3} oxidation (80% conversion at 400 degrees C), which coincides with the decrease in performance.

Toops, Todd J [ORNL; Nguyen, Ke [University of Tennessee, Knoxville (UTK); Foster, Adam [University of Tennessee, Knoxville (UTK); Bunting, Bruce G [ORNL; Hagaman, Edward {Ed} W [ORNL; Jiao, Jian [ORNL

2010-01-01T23:59:59.000Z

478

Energy implications of an aging population  

SciTech Connect (OSTI)

This study provides various demographic, medical, and economic information relative to energy usage on a segment of the population, the elderly, which is growing in absolute numbers and relative population percentage. This growth is expected to continue well into the twenty-first century. The US aging population numbered 3.1 million in 1900, and by 1977 it had climbed to 23.5 million. It can be stated with reasonable certainty that this figure will rise to 31 million in the year 2000 and 43 million in the year 2020. These figures, corresponding to more than 10% of our population, are by no means insignificant. As our fossil-fuel reserves are being depleted and the cost of energy mounts, it becomes apparent that the elderly will become increasingly vulnerable to the energy crisis, primarily beause of their physical tendency to infirmity, their economic and social situation, and their susceptibility to psychological depression. This white paper concentrates on those aspects of aging and the nation's energy problem which are not usually related in our everyday consideration of these as separable problems. It seeks to identify the peculiar energy problems of the aged and to consider alternatives in the solution of these problems in light of modern technology.

Not Available

1980-08-01T23:59:59.000Z

479

Age-dependent decay in the landscape  

E-Print Network [OSTI]

The picture of the "multiverse" arising in diverse cosmological scenarios involves transitions between metastable vacuum states. It was pointed out by Krauss and Dent that the transition rates decrease at very late times, leading to a dependence of the transition probability between vacua on the age of each vacuum region. I investigate the implications of this non-Markovian, age-dependent decay on the global structure of the spacetime in landscape scenarios. I show that the fractal dimension of the eternally inflating domain is precisely equal to 3, instead of being slightly below 3 in scenarios with purely Markovian, age-independent decay. I develop a complete description of a non-Markovian landscape in terms of a nonlocal master equation. Using this description I demonstrate by an explicit calculation that, under some technical assumptions about the landscape, the probabilistic predictions of our position in the landscape are essentially unchanged, regardless of the measure used to extract these predictions. I briefly discuss the physical plausibility of realizing non-Markovian vacuum decay in cosmology in view of the possible decoherence of the metastable quantum state.

Sergei Winitzki

2007-12-14T23:59:59.000Z

480

/ http://www.sciencemag.org/content/early/recent / 5 June2014 / Page 1 / 10.1126/science.1250220 From infectious disease to stem cells and cancer, therapeutic manip-  

E-Print Network [OSTI]

expression reaches sufficient levels, HIV's auto-regulatory gene products (i.e., Tat and Rev) drive and result in substantial cell-to-cell variability. For pathogens that establish persistent states (e.g., HIV challenging. HIV can enter a long-lived proviral latent state (Fig. 1A) that is a leading obstacle to a cure

Napp, Nils

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481

The perlecan heparan sulfate proteoglycan mediates cellular uptake of HIV-1 Tat through a pathway responsible for biological activity  

SciTech Connect (OSTI)

Cell surface heparan sulfate proteoglycans (HSPGs) mediate internalization of HIV-1 Tat. Herein, we report that human WiDr cells, which express perlecan but no other HSPGs, can internalize {sup 125}I-labeled Tat with minimal lysosomal degradation. Pre-treatment of cells with heparitinase almost completely abolished {sup 125}I-Tat surface binding, while the use of an HIV-1 long terminal repeat (LTR) promoter-reporter construct demonstrated that transactivation was potently blocked by pretreatment of cells with heparitinase, indicating an essential role for perlecan in the biologic effects of Tat. We conclude that the perlecan mediates Tat uptake and is required for HIV-1 LTR-directed transactivation in this human cell type.

Argyris, Elias G. [Dorrance H. Hamilton Laboratories, Division of Infectious Diseases and Environmental Medicine, Center for Human Virology and Biodefense, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Kulkosky, Joseph [Dorrance H. Hamilton Laboratories, Division of Infectious Diseases and Environmental Medicine, Center for Human Virology and Biodefense, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Meyer, Marie E. [Dorrance H. Hamilton Laboratories, Department of Medicine, Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Xu Yan [Dorrance H. Hamilton Laboratories, Division of Infectious Diseases and Environmental Medicine, Center for Human Virology and Biodefense, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Mukhtar, Muhammad [Dorrance H. Hamilton Laboratories, Division of Infectious Diseases and Environmental Medicine, Center for Human Virology and Biodefense, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 (United States); Pomerantz, Roger J. [Dorrance H. Hamilton Laboratories, Division of Infectious Diseases and Environmental Medicine, Center for Human Virology and Biodefense, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 (United States)]. E-mail: roger.j.pomerantz@jefferson.edu; Williams, Kevin Jon [Dorrance H. Hamilton Laboratories, Department of Medicine, Division of Endocrinology, Diabetes and Metabolic Diseases, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107 (United States)]. E-mail: K_Williams@mail.jci.tju.edu

2004-12-20T23:59:59.000Z

482

EIA - Annual Energy Outlook 2013 Early Release  

Gasoline and Diesel Fuel Update (EIA)

Electricity Generation Electricity Generation Total electricity consumption in the AEO2013 Reference case, including both purchases from electric power producers and on-site generation, grows from 3,841 billion kilowatthours in 2011 to 4,930 billion kilowatthours in 2040, an average annual rate of 0.9 percent-about the same rate as in the AEO2012 Reference case through 2035. The combination of slow growth in electricity demand, competitively priced natural gas, programs encouraging renewable fuel use, and the implementation of new environmental rules dampens future coal use. The AEO2013 Reference case assumes implementation of the CAIR as a result of an August 2012 federal court decision to vacate the CSAPR. The lower natural gas prices in the early years of the AEO2013 Reference case result in

483

Early Cook County Roads -- Part Two  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

Two Two Nature Bulletin No. 739 January 18, 1964 Forest Preserve District of Cook County Seymour Simon, President Roberts Mann, Conservation Editor EARLY COOK COUNTY ROADS -- PART TWO -- THE PLANK ROAD ERA For ten years after Chicago, with a population of 4,170, was chartered as a city in 1837, its commerce and growth were crippled by wretched transportation to and from the hinterlands. During many periods of each year it was surrounded and isolated by mud. To be sure, there were dirt thoroughfares in all directions, graded and drained as best they could in those days, but not surfaced. No one who has never experienced it can appreciate how gooey and gluey a black prairie soil can be when wet. A wagon's wheels often become solid cylinders of mud as wide as a bass drum.

484

EIA - Annual Energy Outlook 2014 Early Release  

Gasoline and Diesel Fuel Update (EIA)

Executive Summary Executive Summary Projections in the Annual Energy Outlook 2014 (AEO2014) Reference case focus on the factors that shape U.S. energy markets through 2040, under the assumption that current laws and regulations remain generally unchanged throughout the projection period. The early release provides a basis for the examination and discussion of energy market trends and serves as a starting point for analysis of potential changes in U.S. energy policies, rules, or regulations or possible technology breakthroughs. Readers are encouraged to review the full range of cases that will be presented when the complete AEO2014 is released in 2014, exploring key uncertainties in the Reference case. Major highlights of the AEO2014 Reference case include: Growing domestic production of natural gas and crude oil continues to

485

2017 Levelized Costs AEO 2012 Early Release  

Gasoline and Diesel Fuel Update (EIA)

2018 Levelized Costs AEO 2013 1 2018 Levelized Costs AEO 2013 1 January 2013 Levelized Cost of New Generation Resources in the Annual Energy Outlook 2013 This paper presents average levelized costs for generating technologies that are brought on line in 2018 1 as represented in the National Energy Modeling System (NEMS) for the Annual Energy Outlook 2013 (AEO2013) Early Release Reference case. 2 Both national values and the minimum and maximum values across the 22 U.S. regions of the NEMS electricity market module are presented. Levelized cost is often cited as a convenient summary measure of the overall competiveness of different generating technologies. It represents the per-kilowatthour cost (in real dollars) of building and operating a generating plant over an assumed financial life and duty cycle. Key

486

EIA - Annual Energy Outlook 2013 Early Release  

Gasoline and Diesel Fuel Update (EIA)

Annual Energy Outlook 2013 Annual Energy Outlook 2013 Release Dates: April 15 - May 2, 2013 | Next Early Release Date: December 16, 2013 (See release cycle changes) | correction | full report Overview Data Reference Case Side Cases Interactive Table Viewer Topics Source Oil/Liquids Natural Gas Coal Electricity Renewable/Alternative Nuclear Sector Residential Commercial Industrial Transportation Energy Demand Other Emissions Prices Macroeconomic International Efficiency Publication Chapter Market Trends Issues in Focus Legislation & Regulations Comparison Appendices Table Title Formats Summary Reference Case Tables Year-by-Year Reference Case Tables Table 1. Total Energy Supply and Disposition Summary Table 2. Energy Consumption by Sector and Source Table 3. Energy Prices by Sector and Source Table 4. Residential Sector Key Indicators and Consumption

487

EIA - Annual Energy Outlook 2013 Early Release  

Gasoline and Diesel Fuel Update (EIA)

Annual Energy Outlook 2013 Annual Energy Outlook 2013 Release Dates: April 15 - May 2, 2013 | Next Early Release Date: December 2013 (See release cycle changes) | correction | full report Overview Data Reference Case Side Cases Interactive Table Viewer Topics Source Oil/Liquids Natural Gas Coal Electricity Renewable/Alternative Nuclear Sector Residential Commercial Industrial Transportation Energy Demand Other Emissions Prices Macroeconomic International Efficiency Publication Chapter Market Trends Issues in Focus Legislation & Regulations Comparison Appendices Table Title Formats Summary Reference Case Tables Year-by-Year Reference Case Tables Table 1. Total Energy Supply and Disposition Summary Table 2. Energy Consumption by Sector and Source Table 3. Energy Prices by Sector and Source Table 4. Residential Sector Key Indicators and Consumption

488

EIA - Annual Energy Outlook 2012 Early Release  

Gasoline and Diesel Fuel Update (EIA)

Economic growth Economic growth Recovery from the 2008-2009 recession is expected to show the slowest growth of any recovery since 1960. Table 2 compares average annual growth rates over a five-year period following U.S. recessions that have occurred since 1960. For the most recent recession, the expected five-year average annual growth rate in real GDP from 2009 to 2014 is 1.3 percentage points below the corresponding average for the three past recessions, with consumption and non-farm employment recovering even more slowly. The slower growth in the early years of the projection has implications for the long term, with a lower economic growth rate leading to a slower recovery in employment and higher unemployment rates. Real GDP in 2035 is 4 percent lower in the AEO2012 Reference case than was projected in the AEO2011

489

Discovering colorons at the early stage LHC  

SciTech Connect (OSTI)

Prospects are investigated for the discovery of massive hypergluons using data from the early runs of the Large Hadron Collider. A center of mass energy of 7 TeV and an integrated luminosity of 1 fb{sup -1} or 5 fb{sup -1} are assumed. A phenomenological Lagrangian is adopted to evaluate the cross section of a pair of colored vector bosons (colorons, {rho}-tilde) decaying into four colored scalar resonances (hyperpions, {pi}-tilde), which then decay into eight gluons. The dominant eight-jet background from the production of 8g, 7g1q, 6g2q, and 5g3q is included. We find an abundance of signal events and that realistic cuts reduce the background enough to establish a 5{sigma} signal for the coloron mass of up to 733 GeV with 1 fb{sup -1} or 833 GeV with 5 fb{sup -1}.

Dicus, Duane A. [Center for Particles and Fields and Texas Cosmology Center, University of Texas, Austin, Texas 78712 (United States); Kao, Chung; Sayre, Joshua [Homer L. Dodge Department of Physics and Astronomy and Oklahoma Center for High Energy Physics, University of Oklahoma, Norman, Oklahoma 73019 (United States); Nandi, S. [Department of Physics and Oklahoma Center for High Energy Physics, Oklahoma State University, Stillwater, Oklahoma 74078 (United States)

2011-05-01T23:59:59.000Z

490

Thermodynamics in the Viscous Early Universe  

E-Print Network [OSTI]

Assuming that the matter filling the background geometry in the Early Universe was a free gas and no phase transitions took place, we discuss the thermodynamics of this closed system using classical approaches. We found that essential cosmological quantities, such as the Hubble parameter $H$, the scaling factor $a$ and the curvature parameter $k$, can be derived from this simple model. The results are compatible with the Friedmann-Robertson-Walker model and Einstein field equations. Including finite bulk viscosity coefficient leads to important changes in the cosmological quantities. Accordingly, our picture about evolution of the Universe and its astrophysical consequences seems to be a subject of radical revision. We found that $k$ strongly depends on thermodynamics of the cosmic background matter. The time scale, at which negative curvature might take place, depends on the relation between the matter content and the total energy. Using quantum and statistical approaches, we introduced expressions for $H$ a...

Tawfik, A

2010-01-01T23:59:59.000Z

491

Early Screening for Antibody-mediated Rejection in Heart Transplant Recipients  

Science Journals Connector (OSTI)

Background The International Society for Heart and Lung Transplantation (ISHLT) recently established a diagnostic scheme for antibody-mediated rejection (AMR). Currently, however, confirmatory immunohistochemistry studies are recommended only if AMR is clinically or histologically suspected. In this study, we examine whether a pattern of repetitive AMR occurred early enough after transplantation to warrant prospective immunohistochemistry screening in all recently transplanted recipients. Methods We queried our pathology database of adult and pediatric endomyocardial biopsies (EMBs) from 1985 to 2005. All EMB specimens were prospectively studied by immunofluorescence in the early post-operative period. AMR was defined as the presence of complement and immunoglobulin deposits on frozen section. Only patients classified as antibody-mediated rejectors (?3 episodes of AMR) were included. Cumulative incidence and time from transplant to first and third AMR episodes were obtained. Results Three hundred seventy-five of 870 heart transplant recipients had ?3 episodes of AMR. Mean age of recipients was 45.6 years and 78% were male. A total of 19,569 \\{EMBs\\} comprised the study data. By 100 days post-transplant, 85% of patients had their first and 54% their third AMR. In addition, patients showed a clear trend of early clustering of AMR-positive biopsies. Results were similar regardless of whether or not muromonab-CD3 (Orthoclone OKT3) induction was used. Conclusions We advocate early immunohistochemical surveillance testing for AMR to supplement the diagnostic algorithm established by the ISHLT, because a pattern of AMR becomes manifest soon after transplantation. This change will allow earlier detection of asymptomatic AMR and may prompt changes in immunosuppression strategies to avoid adverse outcomes.

Abdallah G. Kfoury; M. Elizabeth H. Hammond; Gregory L. Snow; Josef Stehlik; Bruce B. Reid; James W. Long; Edward M. Gilbert; Feras M. Bader; David A. Bull; Dale G. Renlund

2007-01-01T23:59:59.000Z

492

E-Print Network 3.0 - apobec3g restricts early Sample Search...  

Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

complex is then able to ubiquitinate the APOBEC3G factor bound to Vif by its N... HIV Research (2008) 6, 91-99. Key ... Source: Ecole Polytechnique, Centre de mathmatiques...

493

High rates of police detention among recently released HIV-infected prisoners in Ukraine: Implications for health outcomes  

Science Journals Connector (OSTI)

AbstractBackground Ukraine's HIV epidemic, primarily affecting people who inject drugs (PWID), is expanding and transitioning despite free opioid substitution therapy (OST) and antiretroviral therapy (ART), two effective ways to reduce HIV transmission. Police detention of PWID not resulting in a formal charge or imprisonment is common, but its prevalence and impact on health are not known. Method HIV-infected individuals (N = 97) released from prison within one year were recruited and surveyed in two HIV-endemic Ukrainian cities about post-release police detention experiences. Data on the frequency of police detention, related adverse events, and impact on OST and ART continuity were collected, and correlates of detention were examined using logistic regression. Results Detention responses were available for 94 (96.9%) participants, of which 55 (58.5%) reported police detentions (mean = 9.4 per person-year). For those detained while prescribed OST (N = 28) and ART (N = 27), medication interruption was common (67.9% and 70.4%, respectively); 23 of 27 participants prescribed OST (85.2%) were detained en route to/from OST treatment. Significant independent correlates of detention without charges included post-release ART prescription (AOR 4.98, p = 0.021), current high-risk injection practices (AOR 5.03, p = 0.011), male gender (AOR 10.88, p = 0.010), and lower lifetime months of imprisonment (AOR 0.99, p = 0.031). Conclusions HIV-infected individuals recently released from prison in Ukraine experience frequent police detentions, resulting in withdrawal symptoms, confiscation of syringes, and interruptions of essential medications, including ART and OST. Structural changes are urgently needed to reduce police detentions in order to control HIV transmission and improve both individual and public health.

Jacob M. Izenberg; Chethan Bachireddy; Michael Soule; Tetiana Kiriazova; Sergey Dvoryak; Frederick L. Altice

2013-01-01T23:59:59.000Z

494

Design, Synthesis, and Biological Evaluation of Highly Potent Small Molecule–Peptide Conjugates as New HIV-1 Fusion Inhibitors  

Science Journals Connector (OSTI)

Among them, conjugates Aoc??Ala–P26 and Noc??Ala–P26 exhibited a low nanomolar IC50 in the cell–cell fusion assay and effectively inhibited T20-sensitive and -resistant HIV-1 strains. ... (15) Although C-peptide fusion inhibitors are very potent at inhibiting HIV-1 infection, appearance of T20-resisitant strains, high production cost, and lack of oral bioavailability hinder its further development; thus, these drawbacks have led to a blooming discovery of small molecule fusion inhibitors targeting the gp41 fusion intermediate. ...

Chao Wang; Weiguo Shi; Lifeng Cai; Lu Lu; Qian Wang; Tianhong Zhang; Jinglai Li; Zhenqing Zhang; Kun Wang; Liang Xu; Xifeng Jiang; Shibo Jiang; Keliang Liu

2013-03-04T23:59:59.000Z

495

Generic Difference between Early and Late Stages of BATSE  

Science Journals Connector (OSTI)

The early and late stages of gamma-ray bursts are studied in a statistical analysis of the large sample of long BATSE events. The primary peak is used as the boundary between the early and late stages of emission. Significant differences are found between the stages: the early stage is shorter, it has harder emission, and it becomes a smaller fraction of the total burst duration for burst groups of decreasing intensity.

Igor; Maxim; Dmitrij; Anton; Michael; William; Geoffrey; Robert; Charles

2001-01-01T23:59:59.000Z

496

On the seismic age of the Sun  

E-Print Network [OSTI]

We use low-degree acoustic modes obtained by the BiSON to estimate the main-sequence age $t_\\odot$ of the Sun. The calibration is accomplished by linearizing the deviations from a standard solar model the seismic frequencies of which are close to those of the Sun. Formally, we obtain the preliminary value $t_\\odot=4.68\\pm0.02 $Gy, coupled with an initial heavy-element abundance $Z=0.0169\\pm0.0005$. The quoted standard errors, which are not independent, are upper bounds implied under the assumption that the standard errors in the observed frequencies are independent.

G. Houdek; D. O. Gough

2007-10-03T23:59:59.000Z

497

Presidential Early Career Awards for Scientists and Engineers (PECASE) |  

Office of Science (SC) Website

Presidential Early Presidential Early Career Awards for Scientists and Engineers (PECASE) About Organization Budget Field Offices Federal Advisory Committees History Scientific and Technical Information Honors & Awards Presidential Early Career Awards for Scientists and Engineers (PECASE) DOE's Winners Since 1996 Ceremony The Enrico Fermi Award The Ernest Orlando Lawrence Award DOE Nobel Laureates Federal Laboratory Consortium Excellence in Technology Transfer Award R&D 100 Awards Jobs Brochures, Logos, & Information Resources Contact Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 P: (202) 586-5430 Honors & Awards Presidential Early Career Awards for Scientists and Engineers (PECASE) Print Text Size: A A A RSS Feeds

498

Hickam Air Force Base Fuel Cell Vehicles: Early Implementation Experience  

Broader source: Energy.gov [DOE]

This report sumarizes early implementation experience from an evaluation of two prototype fuel cell vehicles operating at Hickam Air Force Base in Honolulu, Hawaii.

499

Early Markets: Fuel Cells for Material Handling Equipment | Department...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Material Handling Equipment Early Markets: Fuel Cells for Material Handling Equipment This fact sheet describes the use of hydrogen fuel cells to power material handling equipment...

500

Church, society, and the sacred in early christian Greece.  

E-Print Network [OSTI]

??This dissertation proposes a social analysis of the Early Christian basilicas (4th-6 th century) of Southern and Central Greece, predominantly those in the Late Roman… (more)

Caraher, William R

2003-01-01T23:59:59.000Z