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1

Protein Structure Could Lead to Better Treatments for HIV, Early...  

NLE Websites -- All DOE Office Websites (Extended Search)

Highlights rss feed Protein Structure Could Lead to Better Treatments for HIV, Early Aging APRIL 9, 2013 Bookmark and Share Ribbon diagram of the Ste24p protease. Researchers...

2

Successful cognitive aging in persons living with HIV infection  

E-Print Network (OSTI)

Successful cognitive aging (SCA) was operationally definedrisk factors imposed by aging and HIV, there is considerableuals with HIV who are “aging successfully” (e.g. , free from

2011-01-01T23:59:59.000Z

3

Project: Early-Age Performance of Concrete  

Science Conference Proceedings (OSTI)

... at the international workshop "Micro-structure, setting and aging of cement ... Solution Chemistry and Phase Evolution in Early-Age Concrete Materials ...

2012-12-31T23:59:59.000Z

4

A Sampling Plan of HIV Drug Resistance Early Warning Indicators in China  

Science Conference Proceedings (OSTI)

In this paper, a sampling plan of HIV drug resistance early warning indicators (EWI-HIVDR) in China is discussed, for a limited discrete population. The relative error standard of the accuracy control is established, and the formula of the sample size ... Keywords: HIV/AIDS, EWI-HIVDR, Limited discrete population, Accuracy control

Gang Liu; Litao Han

2009-03-01T23:59:59.000Z

5

Antibody Evolution Could Guide HIV Vaccine Development | Advanced...  

NLE Websites -- All DOE Office Websites (Extended Search)

Breakthrough Protein Structure Could Lead to Better Treatments for HIV, Early Aging The Superpower behind Iron Oxyfluoride Battery Electrodes Watching a Protein as it...

6

Additive effects of aging and HIV infection on category verbal fluency : an analysis of component processes  

E-Print Network (OSTI)

E. B. (2003). Alcohol, aging, and cognitive performance: Acomparison. Journal of Aging and Health, 15, 371-390.2006). Neural plasticity in the aging brain. Nature Reviews

Iudicello, Jennifer E.

2011-01-01T23:59:59.000Z

7

HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of apobec  

Science Conference Proceedings (OSTI)

The pattern of viral diversification in newly infected individuals provides information about the host environment and immune responses typically experienced by the newly transmitted virus. For example, sites that tend to evolve rapidly across multiple early-infection patients could be involved in enabling escape from common early immune responses, represent adaptation for rapid growth in a newly infected host, or reversion from less fit forms of the virus that were selected for immune escape in previous hosts. Here we investigated the diversification of HIV -I env coding sequences in 81 very early B SUbtype infections previously shown to have resulted from transmission or expansion of single viruses (n=78) or two closely related viruses (n=3). In these cases the sequence of the infecting virus can be estimated accurately, enabling inference of both the direction of substitutions as well as distinction between insertion and deletion events. By integrating information across multiple acutely infected hosts, we find evidence of adaptive evolution of HIV-1 envand identified a subset of codon sites that diversified more rapidly than can be explained by a model of neutral evolution. Of 24 such rapidly diversifying sites, 14 were either (i) clustered and embedded in CTL epitopes that were verified experimentally or predicted based on the individual's HLA or (ii) in a nucleotide context indicative of APOBEC mediated G-to-A substitutions, despite having excluded heavily hypermutated sequences prior to the analysis. In several cases, a rapidly evolving site was both embedded in an APOBEC motif and in a CTL epitope, suggesting that APOBEC may facilitate early immune escape. Ten rapidly diversifying sites could not be explained by CTL escape or APOBEC hypermutation, including the most frequently mutated site, in the fusion peptide of gp4l. We also examined the distribution, extent, and sequence context of insertions and deletions and provide evidence that the length variation seen in hypervariable loop regions of the envelope glycoprotein is a consequence of selection and not mutational hotspots. These results provide a detailed view of the process of diversification of HIV-1 following transmission.

Korber, Bette [Los Alamos National Laboratory; Bhattacharya, Tanmoy [Los Alamos National Laboratory; Giorgi, Elena [Los Alamos National Laboratory; Gaschen, B [Los Alamos National Laboratory; Daniels, M [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

8

Feeding the periphery : modeling early Bronze Age economies and the cultural landscape of the Faynan District, Southern Jordan.  

E-Print Network (OSTI)

??The current study investigates the evolution of southern Levantine societies during the early Bronze Age (ca 3600- 2000 BCE). This study contributes to the reinvestigation… (more)

Muniz, Adolfo A.

2007-01-01T23:59:59.000Z

9

Early Jurassic shale chemostratigraphy and UPb ages from the Neuqun Basin (Argentina): Implications for the Toarcian Oceanic Anoxic Event  

E-Print Network (OSTI)

Early Jurassic shale chemostratigraphy and U­Pb ages from the Neuquén Basin (Argentina shale section in the Neuquén Basin, Argentina, are presented in order to better constrain the triggering. Chemostratigraphy from a 65 m thick shale-dominated marine section of Late Pliensbachian to Early Toarcian age shows

Svensen, Henrik

10

The Ages and Metallicities of Early Type Galaxies in the Fornax Cluster  

E-Print Network (OSTI)

We have measured central line strengths for a complete sample of early type galaxies in the Fornax cluster, comprising 11 elliptical and 11 lenticular galaxies, more luminous than M_B=-17. In contrast to the elliptical galaxies in the sample studied by Gonzalez (and recently revisited by Trager) we find that the Fornax ellipticals follow the locus of galaxies of fixed age in Worthey's models and have metallicities varying from roughly solar to three times solar. The lenticular galaxies however exhibit a substantial spread to younger luminosity weighted ages indicating a more extended star formation history. We present measurements of the more sensitive indices: C4668 and Hgamma_A; these confirm and re-enforce the conclusions that the elliptical galaxies are coeval and that only the lenticular galaxies show symptoms of late star-formation. The inferred difference in the age distribution between lenticular and elliptical galaxies is a robust conclusion as the models generate consistent relative ages using different age and metallicity indicators even though the absolute ages remain uncertain. The young luminosity weighted ages of the S0s in the Fornax cluster are consistent with the recent discovery that the fraction of S0 galaxies in intermediate redshift clusters is a factor of 2-3 lower than found locally and suggests that a fraction of the cluster spiral galaxy population has evolved to quiescence in the 5 Gyr interval from z=0.5 to the present. Two of the faintest lenticular galaxies in our sample have blue continua and strong Balmer-line absorption suggesting starbursts \\la2 Gyrs ago. These may be the low redshift analogues of the starburst or post-starburst galaxies seen in clusters at z=0.3, similar to the Hdelta strong galaxies in the Coma cluster.

Harald Kuntschner; Roger L. Davies

1997-10-16T23:59:59.000Z

11

Prediction of early-age cracking of UHPC materials and structures : a thremo-chemo-mechanics approach  

E-Print Network (OSTI)

Ultra-High Performance Concrete [UHPC] has remarkable performance in mechanical properties, ductility, economical benefit, etc., but early-age cracking of UHPC can become an issue during the manufacturing process due to ...

Shim, JongMin, 1975-

2005-01-01T23:59:59.000Z

12

Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Aging Name: davida Status: NA Age: NA Location: NA Country: NA Date: Around 1993 Question: What causes aging to occur? Replies: A deep and far-reaching question Aging is...

13

Improved age control on early Homo fossils from the upper Burgi Member at Koobi Fora, Kenya  

E-Print Network (OSTI)

. of Geology and Anthropology, Rutgers University, 610 Taylor Road, Piscataway NJ, USA e Dept. of Human, magnetostratigraphy, Olduvai chron, Pre-Olduvai event, strontium isotope ratios, precession, eccentricity, climate and strontium (Sr) isotope stratigraphy, to improve age control on hominin-bearing upper Burgi (UBU) deposits

14

A thermal active restrained shrinkage ring test to study the early age concrete behaviour of massive structures  

Science Conference Proceedings (OSTI)

In massive concrete structures, cracking may occur during hardening, especially if autogenous and thermal strains are restrained. The concrete permeability due to this cracking may rise significantly and thus increase leakage (in tank, nuclear containment...) and reduce the durability. The restrained shrinkage ring test is used to study the early age concrete behaviour (delayed strains evolution and cracking). This test shows, at 20 {sup o}C and without drying, for a concrete mix which is representative of a French nuclear power plant containment vessel (w/c ratio equal to 0.57), that the amplitude of autogenous shrinkage (about 40 {mu}m/m for the studied concrete mix) is not high enough to cause cracking. Indeed, in this configuration, thermal shrinkage is not significant, whereas this is a major concern for massive structures. Therefore, an active test has been developed to study cracking due to restrained thermal shrinkage. This test is an evolution of the classical restrained shrinkage ring test. It allows to take into account both autogenous and thermal shrinkages. Its principle is to create the thermal strain effects by increasing the temperature of the brass ring (by a fluid circulation) in order to expand it. With this test, the early age cracking due to restrained shrinkage, the influence of reinforcement and construction joints have been experimentally studied. It shows that, as expected, reinforcement leads to an increase of the number of cracks but a decrease of crack widths. Moreover, cracking occurs preferentially at the construction joint.

Briffaut, M. [LMT/ENS Cachan/CNRS UMR8535/UPMC/PRES UniverSud Paris, Cachan (France); Institut de radioprotection et de surete nucleaire, Fontenay-aux-Roses (France); Benboudjema, F. [LMT/ENS Cachan/CNRS UMR8535/UPMC/PRES UniverSud Paris, Cachan (France); Torrenti, J.M., E-mail: jean-michel.torrenti@lcpc.f [Universite Paris Est, Laboratoire central des ponts et chaussees, Paris (France); Nahas, G. [LMT/ENS Cachan/CNRS UMR8535/UPMC/PRES UniverSud Paris, Cachan (France); Institut de radioprotection et de surete nucleaire, Fontenay-aux-Roses (France)

2011-01-15T23:59:59.000Z

15

PLANETARY-SCALE STRONTIUM ISOTOPIC HETEROGENEITY AND THE AGE OF VOLATILE DEPLETION OF EARLY SOLAR SYSTEM MATERIALS  

SciTech Connect

Isotopic anomalies in planetary materials reflect both early solar nebular heterogeneity inherited from presolar stellar sources and processes that generated non-mass-dependent isotopic fractionations. The characterization of isotopic variations in heavy elements among early solar system materials yields important insight into the stellar environment and formation of the solar system, and about initial isotopic ratios relevant to long-term chronological applications. One such heavy element, strontium, is a central element in the geosciences due to wide application of the long-lived {sup 87}Rb-{sup 87}Sr radioactive as a chronometer. We show that the stable isotopes of Sr were heterogeneously distributed at both the mineral scale and the planetary scale in the early solar system, and also that the Sr isotopic heterogeneities correlate with mass-independent oxygen isotope variations, with only CI chondrites plotting outside of this correlation. The correlation implies that most solar system material formed by mixing of at least two isotopically distinct components: a CV-chondrite-like component and an O-chondrite-like component, and possibly a distinct CI-chondrite-like component. The heterogeneous distribution of Sr isotopes may indicate that variations in initial {sup 87}Sr/{sup 86}Sr of early solar system materials reflect isotopic heterogeneity instead of having chronological significance, as interpreted previously. For example, given the differences in {sup 84}Sr/{sup 86}Sr between calcium aluminum inclusions and eucrites ({epsilon}{sup 84}Sr > 2), the difference in age between these materials would be {approx}6 Ma shorter than previously interpreted, placing the Sr chronology in agreement with other long- and short-lived isotope systems, such as U-Pb and Mn-Cr.

Moynier, Frederic; Podosek, Frank A. [Department of Earth and Planetary Science and McDonnell Center for Space Sciences, Washington University, St. Louis, MO 63130 (United States); Day, James M. D. [Geosciences Research Division, Scripps Institution of Oceanography, La Jolla, CA 92093-0244 (United States); Okui, Wataru; Yokoyama, Tetsuya [Department of Earth and Planetary Sciences, Tokyo Institute of Technology, Tokyo 152-8551 (Japan); Bouvier, Audrey [Department of Earth Sciences, University of Minnesota, Minneapolis, MN 55455-0231 (United States); Walker, Richard J., E-mail: moynier@levee.wustl.edu, E-mail: fap@levee.wustl.edu, E-mail: jmdday@ucsd.edu, E-mail: rjwalker@umd.edu, E-mail: okui.w.aa@m.titech.ac.jp, E-mail: tetsuya.yoko@geo.titech.ac.jp, E-mail: abouvier@umn.edu [Department of Geology, University of Maryland, College Park, MD 20742 (United States)

2012-10-10T23:59:59.000Z

16

A Sample of Very Young Field L Dwarfs and Implications for the Brown Dwarf "Lithium Test" at Early Ages  

E-Print Network (OSTI)

Using a large sample of optical spectra of late-type dwarfs, we identify a subset of late-M through L field dwarfs that, because of the presence of low-gravity features in their spectra, are believed to be unusually young. From a combined sample of 303 field L dwarfs, we find observationally that 7.6+/-1.6% are younger than 100 Myr. This percentage is in agreement with theoretical predictions once observing biases are taken into account. We find that these young L dwarfs tend to fall in the southern hemisphere (Dec < 0 deg) and may be previously unrecognized, low-mass members of nearby, young associations like Tucana-Horologium, TW Hydrae, beta Pictoris, and AB Doradus. We use a homogeneously observed sample of roughly one hundred and fifty 6300-10000 Angstrom spectra of L and T dwarfs taken with the Low-Resolution Imaging Spectrometer at the W. M. Keck Observatory to examine the strength of the 6708-A Li I line as a function of spectral type and further corroborate the trends noted by Kirkpatrick et al. (2000). We use our low-gravity spectra to investigate the strength of the Li I line as a function of age. The data weakly suggest that for early- to mid-L dwarfs the line strength reaches a maximum for a few 100 Myr, whereas for much older (few Gyr) and much younger (<100 Myr) L dwarfs the line is weaker or undetectable. We show that a weakening of lithium at lower gravities is predicted by model atmosphere calculations, an effect partially corroborated by existing observational data. Larger samples containing L dwarfs of well determined ages are needed to further test this empirically. If verified, this result would reinforce the caveat first cited in Kirkpatrick et al. (2006) that the lithium test should be used with caution when attempting to confirm the substellar nature of the youngest brown dwarfs.

J. Davy Kirkpatrick; Kelle L. Cruz; Travis S. Barman; Adam J. Burgasser; Dagny L. Looper; C. G. Tinney; Christopher R. Gelino; Patrick J. Lowrance; James Liebert; John M. Carpenter; Lynne A. Hillenbrand; John R. Stauffer

2008-08-22T23:59:59.000Z

17

Early-age concrete temperature and moisture relative to curing effectiveness and projected effects on selected aspects of slab behavior  

E-Print Network (OSTI)

Concrete curing has long been realized to be important to produce durable concrete. Curing compound is widely used to cure concrete in the field. The current curing membrane evaluation method ASTM C 156, however, is incapable of distinguishing the curing compound quality and guiding the curing practice in the field. A new laboratory curing membrane evaluation protocol is developed in this study. It has the ability to rank the quality of curing compound and guide curing practice in the field according to the field ambient weather conditions and the type of curing compound. A series of field tests were conducted to investigate the key factors that affect the curing effectiveness in the field conditions. A finite element program, temperature and moisture analysis for curing concrete (TMAC2), is updated to solve the coupled and nonlinear heat transfer and moisture transport problems in early-age concrete. Moisture capacity is induced into the TMAC2, which makes it unique to characterize the self-desiccation. A full scale concrete pavement test study was conducted at the FAA National Airport Pavement Test Facility (NAPTF) near Atlantic City, New Jersey. In this study, the material properties, i.e. thermal conductivity and moisture diffusivity, were backcalculated from field data. Thereafter, backcalculated material properties were used to forward-calculate the temperature and moisture histories of all other sections. High order shear deformable theory is used to model the concrete slab curling and warping behavior because of highly nonlinear temperature and moisture gradients. The maximum shear strain is obtained a couple of inches below the concrete slab. This might account for the occurrence of delamination.

Ye, Dan

2007-08-01T23:59:59.000Z

18

The peculiar motions of early-type galaxies in two distant regions - V. The Mg-sigma relation, age and metallicity  

E-Print Network (OSTI)

We examine the Mg-sigma relation for early-type galaxies in the EFAR sample and its dependence on cluster properties. A maximum likelihood fit gives global Mg-sigma relations of Mgb'=0.131log(sigma)-0.131 and Mg2=0.257log(sigma)-0.305, with intrinsic scatter of 0.016 mag in Mgb' and 0.023 mag in Mg2. The zeropoint for cD galaxies is higher than for E/S0 galaxies, implying cDs are older and/or more metal-rich than E/S0s with the same sigma. Mg-sigma zeropoint variations between clusters are consistent with the number of galaxies observed per cluster and the global intrinsic scatter in Mg-sigma. We find no significant correlation between the Mg-sigma zeropoint and the cluster velocity dispersion, X-ray luminosity or X-ray temperature over a wide range in cluster mass. We compare the intrinsic scatter in the Mg-sigma and Fundamental Plane (FP) relations with stellar population models to constrain the dispersion in ages, metallicities and M/L ratios for early-type galaxies at fixed sigma. Variations in age alone or metallicity alone cannot explain the measured intrinsic scatter in both Mg-sigma and the FP. We derive the joint constraints on the dispersion in age and metallicity implied by the scatter in the Mg-sigma and FP relations for a simple Gaussian model. We find upper limits on the dispersions at fixed sigma of 32% in dt/t and 38% in dZ/Z if variations in age and metallicity are uncorrelated; only strongly anti-correlated variations lead to significantly higher upper limits. The joint distribution of residuals from the Mg-sigma and FP relations is only marginally consistent with a model having no correlation between age and metallicity, and is better-matched by a model in which age and metallicity variations are moderately anti-correlated, with younger galaxies being more metal-rich. (Abridged)

Matthew Colless; David Burstein; Roger L. Davies; Robert K. McMahan; R. P. Saglia; Gary Wegner

1998-11-05T23:59:59.000Z

19

THE SCHMIDT-KENNICUTT LAW OF MATCHED-AGE STAR-FORMING REGIONS; Pa{alpha} OBSERVATIONS OF THE EARLY-PHASE INTERACTING GALAXY TAFFY I  

SciTech Connect

In order to test a recent hypothesis that the dispersion in the Schmidt-Kennicutt law arises from variations in the evolutionary stage of star-forming molecular clouds, we compared molecular gas and recent star formation in an early-phase merger galaxy pair, Taffy I (UGC 12915/UGC 12914, VV 254) which went through a direct collision 20 Myr ago and whose star-forming regions are expected to have similar ages. Narrowband Pa{alpha} image is obtained using the ANIR near-infrared camera on the mini-TAO 1 m telescope. The image enables us to derive accurate star formation rates within the galaxy directly. The total star formation rate, 22.2 M{sub Sun} yr{sup -1}, was found to be much higher than previous estimates. Ages of individual star-forming blobs estimated from equivalent widths indicate that most star-forming regions are {approx}7 Myr old, except for a giant H II region at the bridge which is much younger. Comparison between star formation rates and molecular gas masses for the regions with the same age exhibits a surprisingly tight correlation, a slope of unity, and star formation efficiencies comparable to those of starburst galaxies. These results suggest that Taffy I has just evolved into a starburst system after the collision, and the star-forming sites are at a similar stage in their evolution from natal molecular clouds except for the bridge region. The tight Schmidt-Kennicutt law supports the scenario that dispersion in the star formation law is in large part due to differences in evolutionary stage of star-forming regions.

Komugi, S. [Joint ALMA Observatory, Alonso de Cordova 3107, Vitacura, Santiago 763-0355 (Chile); Tateuchi, K.; Motohara, K.; Kato, N.; Konishi, M.; Koshida, S.; Morokuma, T.; Takahashi, H.; Tanabe, T.; Yoshii, Y. [Institute of Astronomy, University of Tokyo, Osawa 2-21-1, Mitaka, Tokyo 181-0015 (Japan); Takagi, T. [Institute of Space and Astronautical Science, JAXA, 3-31-1 Yoshinodai, Sagamihara, Kanagawa 229-8510 (Japan); Iono, D.; Kaneko, H.; Ueda, J. [Nobeyama Radio Observatory, National Astronomical Observatory, 462-2 Nobeyama, Minamimaki, Minamisaku, Nagano 384-1305 (Japan); Saitoh, T. R., E-mail: skomugi@alma.cl [Interactive Research Center of Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro 152-0033 (Japan)

2012-10-01T23:59:59.000Z

20

Low dose irradiation of the early vertebrate embryo and early...  

NLE Websites -- All DOE Office Websites (Extended Search)

irradiation of the early vertebrate embryo and early onset of tissue aging Lingling Ding 1,2 , Xuan Zheng 1,3 , Wendy W. Kuhne 4 , David E. Hinton 5 , Jeffrey R. Lee 6 , and...

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease  

SciTech Connect

Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with unique pathways and functions. The low-dose response had two major components: pathways that are consistently seen across tissues, and pathways that were brain tissue specific. Low-dose genes clustered into a saturated network (p < 10{sup -53}) containing mostly down-regulated genes involving ion channels, long-term potentiation and depression, vascular damage, etc. We identified 9 neural signaling pathways that showed a high degree of concordance in their transcriptional response in mouse brain tissue after low-dose radiation, in the aging human brain (unirradiated), and in brain tissue from patients with Alzheimer's disease. Mice exposed to high-dose radiation did not show these effects and associations. Our findings indicate that the molecular response of the mouse brain within a few hours after low-dose irradiation involves the down-regulation of neural pathways associated with cognitive dysfunctions that are also down regulated in normal human aging and Alzheimer's disease.

Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco; Wyrobek, Andrew J.

2008-06-06T23:59:59.000Z

22

Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease  

SciTech Connect

Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with unique pathways and functions. The low-dose response had two major components: pathways that are consistently seen across tissues, and pathways that were brain tissue specific. Low-dose genes clustered into a saturated network (p < 10{sup -53}) containing mostly down-regulated genes involving ion channels, long-term potentiation and depression, vascular damage, etc. We identified 9 neural signaling pathways that showed a high degree of concordance in their transcriptional response in mouse brain tissue after low-dose radiation, in the aging human brain (unirradiated), and in brain tissue from patients with Alzheimer's disease. Mice exposed to high-dose radiation did not show these effects and associations. Our findings indicate that the molecular response of the mouse brain within a few hours after low-dose irradiation involves the down-regulation of neural pathways associated with cognitive dysfunctions that are also down regulated in normal human aging and Alzheimer's disease.

Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco; Wyrobek, Andrew J.

2008-06-06T23:59:59.000Z

23

Contrasting HIV phylogenetic relationships and V3 loop protein similarities  

Science Conference Proceedings (OSTI)

At least five distinct sequence subtypes of HIV-I can be identified from the major centers of the AMS pandemic. While it is too early to tell whether these subtypes are serologically or phenotypically similar or distinct in terms of properties such as pathogenicity and transmissibility, we can begin to investigate their potential for phenotypic divergence at the protein sequence level. Phylogenetic analysis of HIV DNA sequences is being widely used to examine lineages of different viral strains as they evolve and spread throughout the globe. We have identified five distinct HIV-1 subtypes (designated A-E), or clades, based on phylogenetic clustering patterns generated from genetic information from both the gag and envelope (env) genes from a spectrum of international isolates. Our initial observations concerning both HIV-1 and HIV-2 sequences indicate that conserved patterns in protein chemistry may indeed exist across distant lineages. Such patterns in V3 loop amino acid chemistry may be indicative of stable lineages or convergence within this highly variable, though functionally and immunologically critical, region. We think that there may be parallels between the apparently stable HIV-2 V3 lineage and the previously mentioned HIV-1 V3 loops which are very similar at the protein level despite being distant by cladistic analysis, and which do not possess the distinctive positively charged residues. Highly conserved V3 loop protein sequences are also encountered in SIVAGMs and CIVs (chimpanzee viral strains), which do not appear to be pathogenic in their wild-caught natural hosts.

Korber, B. [Los Alamos National Lab., NM (United States)]|[Santa Fe Inst., NM (United States); Myers, G. [Los Alamos National Lab., NM (United States)

1992-12-31T23:59:59.000Z

24

Contrasting HIV phylogenetic relationships and V3 loop protein similarities  

Science Conference Proceedings (OSTI)

At least five distinct sequence subtypes of HIV-I can be identified from the major centers of the AMS pandemic. While it is too early to tell whether these subtypes are serologically or phenotypically similar or distinct in terms of properties such as pathogenicity and transmissibility, we can begin to investigate their potential for phenotypic divergence at the protein sequence level. Phylogenetic analysis of HIV DNA sequences is being widely used to examine lineages of different viral strains as they evolve and spread throughout the globe. We have identified five distinct HIV-1 subtypes (designated A-E), or clades, based on phylogenetic clustering patterns generated from genetic information from both the gag and envelope (env) genes from a spectrum of international isolates. Our initial observations concerning both HIV-1 and HIV-2 sequences indicate that conserved patterns in protein chemistry may indeed exist across distant lineages. Such patterns in V3 loop amino acid chemistry may be indicative of stable lineages or convergence within this highly variable, though functionally and immunologically critical, region. We think that there may be parallels between the apparently stable HIV-2 V3 lineage and the previously mentioned HIV-1 V3 loops which are very similar at the protein level despite being distant by cladistic analysis, and which do not possess the distinctive positively charged residues. Highly conserved V3 loop protein sequences are also encountered in SIVAGMs and CIVs (chimpanzee viral strains), which do not appear to be pathogenic in their wild-caught natural hosts.

Korber, B. (Los Alamos National Lab., NM (United States) Santa Fe Inst., NM (United States)); Myers, G. (Los Alamos National Lab., NM (United States))

1992-01-01T23:59:59.000Z

25

HIV entering the cell  

NLE Websites -- All DOE Office Websites (Extended Search)

NA Question: How does the HIV virus enter the cell, is it through active transport or passive? Could it be endocytosis? Replies: None of these, usually. Many viruses, T4 for...

26

Nonionizing Radiation and HIV  

NLE Websites -- All DOE Office Websites (Extended Search)

Nonionizing Radiation and HIV Name: Flora R Pitchford Location: NA Country: NA Date: NA Question: What are the effects of nonionizing radiation on DNA , RNA or any other cell...

27

REACT: Reducing Early-Age Cracking Today  

Science Conference Proceedings (OSTI)

... rise and temperature gradients in mass concrete construction, including the use of ice as part of the mixing water, chilled aggregates, cooling pipes ...

2008-05-13T23:59:59.000Z

28

Aging gene  

NLE Websites -- All DOE Office Websites (Extended Search)

Aging gene Name: Linda S Martinez Location: NA Country: NA Date: NA Question: Have the aging gene or genes been located on the human chromosomes, and, if yes, will removing that...

29

Aging gauge  

DOE Patents (OSTI)

An aging gauge comprising a container having a fixed or a variable sized t opening with a cap which can be opened to control the sublimation rate of a thermally sublimational material contained within the container. In use, the aging gauge is stored with an item to determine total heat the item is subjected to and also the maximum temperature to which the item has been exposed. The aging gauge container contains a thermally sublimational material such as naphthalene or similar material which has a low sublimation rate over the temperature range from about 70.degree. F. to about 160.degree. F. The aging products determined by analyses of a like item aged along with the aging gauge for which the sublimation amount is determined is employed to establish a calibration curve for future aging evaluation. The aging gauge is provided with a means for determining the maximum temperature exposure (i.e., a thermally indicating material which gives an irreversible color change, Thermocolor pigment). Because of the relationship of doubling reaction rates for increases of 10.degree. C., equivalency of item used in accelerated aging evaluation can be obtained by referring to a calibration curve depicting storage temperature on the abscissa scale and multiplier on the ordinate scale.

Betts, Robert E. (Huntsville, AL); Crawford, John F. (Huntsville, AL)

1989-01-01T23:59:59.000Z

30

Predicting HIV transmission risk among HIV-infected patients seen in clinical settings  

E-Print Network (OSTI)

intervention to reduce HIV transmission risk behavior amongBest- Predicting Transmission Risk Evidence Interventions:use in relation to HIV transmission among gay men. Journal

Morin, Stephen F; Myers, Janet J; Shade, Starley B; Koester, Kimberly; Maiorana, Andre; Rose, Carol Dawson

2007-01-01T23:59:59.000Z

31

The Aging Brain: Are two pathologies worse than one? White matter hyperintensities, beta-amyloid, and cognition in normal elderly  

E-Print Network (OSTI)

related with cognition in aging and early Alzheimer disease,is normal, Neurobiology of Aging, 26.4, 9. Jeerakathil, T. ,related with cognition in aging and early Alzheimer disease,

Onami, Susan

2010-01-01T23:59:59.000Z

32

Early motor repertoire and long-term neurological outcome.  

E-Print Network (OSTI)

??In conclusion, this thesis described the development of both qualitative and quantitative aspects of the early motor repertoire, particularly at around three months’ post-term age… (more)

Bruggink, Janneke Leontien Maria

2009-01-01T23:59:59.000Z

33

Early Career Research Program  

NLE Websites -- All DOE Office Websites (Extended Search)

Office of Science Early Career Research Program Early Career Research Program Overview Divisional Points of Contact Office of Science Early Career Website Important Dates Links and...

34

Web Sites Related to HIV/Aids Web Sites Related to HIV/Aids  

E-Print Network (OSTI)

Web Sites Related to HIV/Aids Web Sites Related to HIV/Aids "Surviving AIDS" httpDreamweaver...20Science/Links/Web%20Sites%20Related%20to%20HIV.htm [10/6/2010 10:56:31 AM] #12;

de Lijser, Peter

35

Low-Voltage Cable Aging Management Guidance  

Science Conference Proceedings (OSTI)

This report, intended for use by power plant engineers and craft and administrative personnel who are responsible for cable system aging management, provides guidance on the effective and efficient application of current information and techniques related to aging and condition monitoring (CM) of low-voltage cables. The identification of cables that are prone to early aging and the timely replacement or repair of cables that are degraded will minimize unnecessary power losses, unplanned shutdowns, ...

2013-12-23T23:59:59.000Z

36

NIAID: Programs in HIV/AIDS Therapeutics  

Science Conference Proceedings (OSTI)

made in the area of HIV/AIDS research has been to give its full support to the .... Site: The Fred Hutchinson Cancer Research Center. r International Maternal ...

37

Aging in American Convents  

E-Print Network (OSTI)

Schuster. Snowdon, David 2001 Aging with Grace: What the Nunreligion, devotion, and aging. CSW JAN09 update tocAging in American Convents FIELDWORK REPORT by Anna I.

Corwin, Anna I.

2009-01-01T23:59:59.000Z

38

Relationships between HIV spread and evolution examined  

NLE Websites -- All DOE Office Websites (Extended Search)

3 » 3 » November » Relationships between HIV spread and evolution examined Relationships between HIV spread and evolution examined Thomas Leitner of LANL and collaborators are investigating the development of HIV from the point of contraction onwards. November 14, 2013 Scanning electron micrograph of HIV-1 budding (in green) from cultured lymphocytes. The image has been colored to highlight important features. Photo credit: C. Goldsmith, Centers for Disease Control and Prevention. Scanning electron micrograph of HIV-1 budding (in green) from cultured lymphocytes. The image has been colored to highlight important features. Photo credit: C. Goldsmith, Centers for Disease Control and Prevention. They are examining the relationships between the spread of the virus in a

39

HIV transcription is induced in dying cells  

SciTech Connect

Using HeLa cells stably transfected with an HIV-LTR-CAT construct, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires functional p53, which is not present in HeLa cells. For all other agents, HIV-LTR induction was dose-dependent and correlated with the amount of cell killing that occurred in the culture. Doses which caused over 99% cell killing induced HIV-LTR transcription maximally, demonstrating that cells that will go on to die by 14 days are the cells expressing HIV-LTR-CAT.

Woloschak, G.E.; Chang-Liu, Chin-Mei [Argonne National Lab., IL (United States); Schreck, S. [Argonne National Lab., IL (United States)]|[Univ. of South Carolina, Columbia, SC (United States). Dept. of Chemistry; Panozzo, J. [Loyola Univ. Medical Center, Maywood, IL (United States); Libertin, C.R. [Loyola Univ. Medical Center, Maywood, IL (United States)

1996-02-01T23:59:59.000Z

40

Low dose irradiation of the early vertebrate embryo and early onset of  

NLE Websites -- All DOE Office Websites (Extended Search)

irradiation of the early vertebrate embryo and early onset of irradiation of the early vertebrate embryo and early onset of tissue aging Lingling Ding Georgia Health Sciences University Abstract There is considerable overlap between cellular and molecular changes that occur in response to low doses of ionizing radiation and those that occur during aging. Both processes are characterized by accumulation of persistent DNA damage (“wear and tear” on the genome), persistent oxidative stress, and depletion of stem/progenitor cells, leading to loss of repair and regenerative capacity. Here we test a hypothesis that exposure to low-dose ionizing radiation accelerates normal, aging-related tissue changes. The work was performed using a small, genetically tractable vertebrate model organism, the Japanese medaka fish (Oryzias latipes). Medaka have a

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

FCT Education: For Early Adopters  

NLE Websites -- All DOE Office Websites (Extended Search)

Education: For Early Adopters on Twitter Bookmark FCT Education: For Early Adopters on Google Bookmark FCT Education: For Early Adopters on Delicious Rank FCT Education: For Early...

42

Influence of Shrinkage-Reducing Admixtures on Early-Age ...  

Science Conference Proceedings (OSTI)

... The value measured for distilled water is in excellent agreement with that provided in the literature (CRC Handbook 1987). ...

2010-12-23T23:59:59.000Z

43

How HIV Infects Cells | Advanced Photon Source  

NLE Websites -- All DOE Office Websites (Extended Search)

Simulating Deep Earthquakes in the Laboratory Simulating Deep Earthquakes in the Laboratory A "Sponge" Path to Better Catalysts and Energy Materials Metal Model Mimics Metalloenzymes New Physics in a Copper-Iridium Compound A Key Target for Diabetes Drugs Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed How HIV Infects Cells September 26, 2013 Bookmark and Share The structure of the CCR5 cell surface receptor, which most strains of HIV use to enter human immune cells. This image shows the HIV drug maraviroc grabbing hold of CCR5 in an inactive conformation that prevents HIV from using the receptor to enter cells. (Image by Katya Kadyshevskaya, The Scripps Research Institute)

44

Thoughts on Aging  

E-Print Network (OSTI)

The impetus of writing about aging came the other day afterMagnetic Resonance Thoughts on Aging George Feher Received:at Springerlink.com When we, aging scientists, fade away and

Feher, George

2010-01-01T23:59:59.000Z

45

Modeling tuberculosis in areas of high HIV prevalence  

Science Conference Proceedings (OSTI)

We describe a discrete event simulation model of tuberculosis (TB) and HIV disease, parameterized to describe the dual epidemics in Harare, Zimbabwe. TB and HIV are the leading causes of death from infectious disease among adults worldwide and the number ...

Georgina R. Hughes; Christine S. M. Currie; Elizabeth L. Corbett

2006-12-01T23:59:59.000Z

46

Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins  

DOE Patents (OSTI)

The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Korber, Bette T. (Los Alamos, NM); Perkins, Simon (Los Alamos, NM); Bhattacharya, Tanmoy (Los Alamos, NM); Fischer, William M. (Los Alamos, NM); Theiler, James (Los Alamos, NM); Letvin, Norman (Boston, MA); Haynes, Barton F. (Durham, NC); Hahn, Beatrice H. (Birmingham, AL); Yusim, Karina (Los Alamos, NM); Kuiken, Carla (Los Alamos, NM)

2012-02-21T23:59:59.000Z

47

Evolving T-cell vaccine strategies for HIV, the virus with a thousand faces  

Science Conference Proceedings (OSTI)

HIV's rapid global spread and the human suffering it has left in its wake have made AIDS a global heath priority for the 25 years since its discovery. Yet its capacity to rapidly evolve has made combating this virus a tremendous challenge. The obstacles to creating an effective HIV vaccine are formidable, but there are advances in the field on many fronts, in terms of novel vectors, adjuvants, and antigen design strategies. SIV live attenuated vaccine models are able to confer protection against heterologous challenge, and this continues to provide opportunities to explore the biological underpinnings of a protective effect (9). More indirect, but equally important, is new understanding regarding the biology of acute infection (43), the role of immune response in long-term non-progression (6,62, 81), and defining characteristics of broadly neutralizing antibodies (4). In this review we will focus on summarizing strategies directed towards a single issue, that of contending with HIV variation in terms of designing aT-cell vaccine. The strategies that prove most effective in this area can ultimately be combined with the best strategies under development in other areas, with the hope of ultimately converging on a viable vaccine candidate. Only two large HIV vaccine efficacy trials have been completed and both have failed to prevent infection or confer a benefit to infected individual (23,34), but there is ample reason to continue our efforts. A historic breakthrough came in 1996, when it was realized that although the virus could escape from a single antiretroviral (ARV) therapy, it could be thwarted by a combination of medications that simultaneously targeted different parts of the virus (HAART) (38). This revelation came after 15 years of research, thought, and clinical testing; to enable that vital progress the research and clinical communities had to first define and understand, then develop a strategy to counter, the remarkable evolutionary potential of the virus. HAART, for the first time, provided an effective treatment to help those with living with HIV stay healthy. Nonetheless, the treatment has limitations. People with HIV face a lifetime of expensive daily multi-drug regimens, often with side effects; drug resistance at the individual and population level are issues (56); and universal access, despite substantial progress, is a dream not yet realized for many of the millions of the world's poor who are living with HIV (68). These issues, combined with the growing numbers of people infected globally and impact of HIV on society, make the development of an HIV vaccine or a prophylactic prevention strategy a crucial if elusive goal. In some ways, the history of HIV vaccine deVelopment has paralleled the early stages of designing effective therapy. We had to test the simple strategies first, but meanwhile the story of the impact of diversity from an immunological perspective is still unfolding, and novel ideas countermeasures are being explored.

Korber, Bette [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

48

A whole genome screen for HIV restriction factors  

E-Print Network (OSTI)

of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. gag/pol/tat and rev, HIV-2 MCR Env). The negative... replication, we developed a single round infectious HIV pseudotype assay to siRNA screen HeLa-CD4 cells. The HIV pseudotype HIV89.6R, has an HIV-2 Env MCR (derived from the primary isolate prCBL-23). HeLa-CD4 cells contain ectopically expressed CD4...

Liu, Li; Oliveira, Nidia MM; Cheney, Kelly M; Pade, Corinna; Dreja, Hanna; Bergin, Ann Marie H; Borgdorff, Viola; Beach, David H; Bishop, Cleo L; Dittmar, Matthias T; McKnight, Aine

2011-11-14T23:59:59.000Z

49

HIV transcription is induced in dying cells  

SciTech Connect

Using HeLa cells stably transfected with an HIV-LTR-CAT construct, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires functional p53, which is not present in HeLa cells. For all other agents, HIV-LTR induction was dose-dependent and correlated with the amount of cell killing that occurred in the culture. 14 refs., 4 figs., 1 tab.

Woloschak, G.E.; Chang-Liu, Chin-Mei [Argonne National Lab., IL (United States); Schreck, S. [Argonne National Lab., IL (United States)]|[Univ. of South Carolina, Columbia, SC (United States). Dept. of Chemistry

1995-06-01T23:59:59.000Z

50

Solutioning and Aging Behaviours  

Science Conference Proceedings (OSTI)

Mar 13, 2012 ... Aluminum Alloys: Fabrication, Characterization and Applications: Solutioning and Aging Behaviours Sponsored by: The Minerals, Metals and ...

51

Solutioning and Aging Behaviors  

Science Conference Proceedings (OSTI)

Aluminum Alloys: Development, Characterization and Applications: Solutioning and Aging Behaviors Sponsored by: TMS Light Metals Division, TMS: Aluminum

52

Aging of SRC liquids  

Science Conference Proceedings (OSTI)

The viscosity of SRC?LL liquid increases when subjected to accelerated aging by bubbling oxygen in the presence of copper strip at 62°C. Precipitates are formed and can be separated from the aged liquid by Soxhlet extraction with pentane. A 30?70 blend of SRC?I with SRC?LL was subjected to oxygen aging in the absence of copper

T. Hara; L. Jones; K. C. Tewari; N. C. Li

1981-01-01T23:59:59.000Z

53

HIV transcription is induced with cell killing  

SciTech Connect

In this report, we demonstrate that this induction of HIV-LTR transcription occurs when stably transfected HeLa cells are exposed to agents which mediate cell killing, such as UV radiation, electroporation of sucrose buffer, prolonged heating, and low and high pH. Cells cultured following UV exposure demonstrated a peak in CAT expression that is evident in viable (but not necessarily cell division-competent) cells 24 h after exposure; this inductive response continued until at least 72 h after exposure. HIV-LTR induction was dose-dependent, and the amount of CAT transcription induced was correlated with the amount of cell killing that occurred in the culture.

Woloschak, G.E.; Schreck, S.; Chang-Liu, Chin-Mei [Argonne National Lab., IL (United States); Panozzo, J.; Libertin, C.R. [Loyola Univ. Medical Center, Maywood, IL (United States)

1993-11-01T23:59:59.000Z

54

Determining age of whales  

NLE Websites -- All DOE Office Websites (Extended Search)

Determining age of whales Determining age of whales Name: Bruce W Walkey Age: N/A Location: N/A Country: N/A Date: N/A Question: While browsing through the Internet, I came upon a question by two fifth grade students. Their question got me thinking and now I pose it to you. How can you determine the age of whales? Since they are mammals, can the methods that are used on humans be used on whales? What are some tests that can be done on bones or tissues to determine age? Looking forward to your reply. Replies: Although it is difficult to determine the age of whales (unless they are born in captivity and we know their birth date), several methods have been commonly used: 1) (if female) the examination of the ovaries 2) Examination of the ridges on baleen, which are not uniform in size and analogous to tree rings. The problem with this is that baleen wears away over time. 3) Studying layers of ossification in an ear bone is probably the most accurate method of aging, since internal bones don't wear away. The biggest problem with aging methods is that they usually require that you are dissecting the animal, and often, we would like a method of aging for live active animals. The best we can do here is to compare the size and markings of whales of known age to those found in the wild. Great question!

55

Early Station Costs Questionnaire  

NLE Websites -- All DOE Office Websites (Extended Search)

Early Station Costs Questionnaire Early Station Costs Questionnaire Marc Melaina Hydrogen Technologies and Systems Center Market Readiness Workshop February 16-17th, 2011 Washington, DC Questionnaire Goals * The Early Station Costs questionnaire provides an anonymous mechanism for organizations with direct experience with hydrogen station costs to provide feedback on current costs, near-term costs, economies of scale, and R&D priorities. * This feedback serves the hydrogen community and government agencies by increasing awareness of the status of refueling infrastructure costs National Renewable Energy Laboratory Innovation for Our Energy Future Questions for Market Readiness Workshop Attendees * Are these questions the right ones to be asking?

56

Demand Side Interventions for the Prevention of Mother to Child Transmission of HIV  

E-Print Network (OSTI)

venting Mother-to-Child Transmission of HIV to Reach themother-to-child HIV transmission in lower-income coun-of mother-to-child HIV transmission (PMTCT) programmes with

Meese, Halea

2011-01-01T23:59:59.000Z

57

Aging Matters What's Inside  

E-Print Network (OSTI)

Aging Matters What's Inside Letter from the dean PSU winS Carter award artiSan eConomy eLi BUi and Public affairs 2008 fall newsletter www.pdx.edu/cupa aGinG is a modern fact of life. In 2006 the world's population of adults aged 60 or over was 650 million. By 2025 that number will nearly double. By 2050

Bertini, Robert L.

58

Materials Degradation and Aging  

Science Conference Proceedings (OSTI)

Aug 28, 2007 ... Improve plant capacity, reliability, and availability. Materials Degradation and Aging - An EPRI Nuclear Power Action Plan, Report No.

59

Pioneering the nuclear age  

SciTech Connect

This paper reviews the historical aspects of nuclear physics. The scientific aspects of the early transuranium elements are discussed and arms control measures are reviewed. 11 refs., 14 figs. (LSP)

Seaborg, G.T.

1988-09-01T23:59:59.000Z

60

A Cellular Automata Model of the Spread of HIV in a ... - CECM  

E-Print Network (OSTI)

published sources [2, 3]. The community is composed of 70%. IDU, with 35% of these infected with HIV, 20% susceptibles;. 5% non-drug user HIV+ individuals ...

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

HIV Transmission Potential Among Local and Migrant Factory Workers in Kolkata, India  

E-Print Network (OSTI)

and source are credited. transmission? Sexually TransmittedReducing heterosexual transmission of HIV in poor countries.of migration on HIV-1 transmission in South Africa: A study

Deb, Alok Kumar; Deb, Manjari; Saha, Malay Kumar; Chakraborty, Shantanu; Bhattacharya, Sujit Kumar; Detels, Roger

2009-01-01T23:59:59.000Z

62

Melatonin and the aging brain  

E-Print Network (OSTI)

mitochondrial decay of aging. Mol. Aspects Med. 26, Ames,the degenerative diseases of aging. Proc. Natl. Acad. Sci.2004. Retardation of brain aging by chronic treatment with

BONDY, S; SHARMAN, E

2007-01-01T23:59:59.000Z

63

HIV-AIDS Information Resources from the NLM - ACIO  

SciTech Connect

As the treatment and management of HIV/AIDS continues to evolve with new scientific breakthroughs, treatment discoveries, and management challenges, it is difficult for people living with HIV/AIDS and those who care for them to keep up with the latest information on HIV/AIDS screening and testing, prevention, treatment, and research. The National Library of Medicine (NLM), of the National Institutes of Health, has a wealth of health information resources freely available on the Internet to address these needs.

Templin-Branner, W.

2010-10-01T23:59:59.000Z

64

AEO2008 Overview - Early Release  

Annual Energy Outlook 2012 (EIA)

Report :DOEEIA-0383(2008) Released Date: December 2007 Next Release Date: December 2008 (full report available early 2008) Annual Energy Outlook 2008 (Early Release)...

65

Early Education Services Family Handbook  

E-Print Network (OSTI)

Early Education Services Family Handbook A Partnership in Caring Effective January 2013 Early an experience of trust, caring, understanding and learning for us all. This handbook provides important

California at Santa Cruz, University of

66

Early Education Services Family Handbook  

E-Print Network (OSTI)

Early Education Services Family Handbook A Partnership in Caring Effective July 2012 Early an experience of trust, caring, understanding and learning for us all. This handbook provides important

California at Santa Cruz, University of

67

AEO2014 Early Release Overview  

U.S. Energy Information Administration (EIA)

U.S. Energy Information Administration Annual Energy Outlook 2014 Early Release Overview 3 AEO2014 Early Release Overview decade for the first time ...

68

Expanding HAART to Control the Spread of HIV Among ... - CECM  

E-Print Network (OSTI)

Each phase diagram above depicts where in the social interaction plane. HIV becomes extinct (green) or endemic (red). Yellow dots show needle-sharing.

69

Modeling HIV Spread Through Sexual Contact Using a ... - CECM  

E-Print Network (OSTI)

[23] R. Danziger, ?The social impact of hiv testing: a comparative analysis of britain and sweden,? Social Science and Medicine, vol. 48, pp. 293?300,. 1999.

70

Transmission and Evolution of Drug Resistant HIV-1 Variants .  

E-Print Network (OSTI)

??In at least 10% of newly diagnosed patients, HIV-1 variants harbouring resistance mutations in protease and reverse transcripase are detected. This thesis describes the impact… (more)

Pingen, M.

2013-01-01T23:59:59.000Z

71

Molecular mechanisms of HIV gp120-induced neurotoxicity  

E-Print Network (OSTI)

G. and M. Kaul. 2010. Molecular mechanisms of neuroinvasionet al. , 2007). However, the molecular mechanism of p38 MAPKOF CALIFORNIA, SAN DIEGO Molecular Mechanisms of HIV gp120-

Medders, Kathryn Elizabeth

2010-01-01T23:59:59.000Z

72

Aging and Holography  

E-Print Network (OSTI)

Aging phenomena are examples of `non-equilibrium criticality' and can be exemplified by systems with Galilean and scaling symmetries but no time translation invariance. We realize aging holographically using a deformation of a non-relativistic version of gauge/gravity duality. Correlation functions of scalar operators are computed using holographic real-time techniques, and agree with field theory expectations. At least in this setup, general aging phenomena are reproduced holographically by complexifying the bulk space-time geometry, even in Lorentzian signature.

Juan I. Jottar; Robert G. Leigh; Djordje Minic; Leopoldo A. Pando Zayas

2010-04-21T23:59:59.000Z

73

Finite Temperature Aging Holography  

E-Print Network (OSTI)

We construct the gravity background which describes the dual field theory with aging invariance. We choose the decay modes of the bulk scalar field in the internal spectator direction to obtain the dissipative behavior of the boundary correlation functions of the dual scalar fields. In particular, the two-time correlation function at zero temperature has the characteristic features of the aging system: power law decay, broken time translation and dynamical scaling. We also construct the black hole backgrounds with asymptotic aging invariance. We extensively study characteristic behavior of the finite temperature two-point correlation function via analytic and numerical methods.

Seungjoon Hyun; Jaehoon Jeong; Bom Soo Kim

2011-08-29T23:59:59.000Z

74

HEU age determination  

SciTech Connect

A technique has been developed to determine the Highly Enriched Uranium (HEU) Age which is defined as the time since the HEU was produced in an enrichment process. The HEU age is determined from the ratios of relevant uranium parents and their daughters viz {sup 230}Th/{sup 234}U and {sup 231}Pa/{sup 235}U. Uranium isotopes are quantitatively measured by their characteristic gammas and their daughters by alpha spectroscopy. In some of the samples where HEU is enriched more than 99%, the only mode of HEU age determination is by the measurement of {sup 231}Pa since there is negligible quantity of {sup 230}Th due to very low atom concentrations of {sup 234}U in the sample. In this paper we have presented data and methodology of finding the age of two HEU samples.

Moorthy, A.R.; Kato, W.Y.

1995-08-01T23:59:59.000Z

75

Speech understanding and aging  

Science Conference Proceedings (OSTI)

The increasing age of the population forecasts a corresponding increase in the number of people suffering from hearing loss and who therefore have difficulty with speech communication. This article

Working Group on Speech Understanding and Aging

1988-01-01T23:59:59.000Z

76

HEU age determination  

SciTech Connect

A new technique has been developed to determine the age of highly enriched uranium (HEU) in solids. Uranium age is defined as the time since the uranium-containing material was last subjected to a process capable of separating uranium from its radioactive-decay daughters. [Most chemical processing, uranium enrichment, volatilization processes, and phase transformations (especially relevant for uranium hexafluoride) can result in separation of the uranium parent material from the decay-product daughters.] Determination of the uranium age, as defined here, may be relevant in verifying arms-control agreements involving uranium-containing nuclear weapons. The HEU age is determined from the ratios of relevant uranium daughter isotopes and their parents, viz {sup 230}Th/{sup 234}U and {sup 231}Pa/{sup 235}U. Uranium isotopes are quantitatively measured by their characteristic gamma rays and their daughters by alpha spectroscopy. In some of the samples, where HEU is enriched more than 99%, the only mode of HEU age determination is by the measurement of {sup 231}Pa since there is negligible quantity of {sup 230}Th due to very low atom concentrations of {sup 234}U in the samples. In this report the methodology and the data for determining the age of two HEU samples are presented.

Moorthy, A.R.; Kato, W.Y.

1997-07-01T23:59:59.000Z

77

Linking information systems for HIV care and research in Kenya  

Science Conference Proceedings (OSTI)

The provision of HIV care in developing countries may involve complex and overlapping resources; including government-run facilities non-governmental organization (NGO) or international non-governmental organization (INGO) supported services and research ... Keywords: data integration, data standards, electronic medical records, hiv, interoperability, ontologies, open source software

Alicia F. Guidry; Judd L. Walson; Neil F. Abernethy

2010-11-01T23:59:59.000Z

78

Dynamic Multidrug Therapies for HIV: Optimal and STI Control Approaches  

E-Print Network (OSTI)

Dynamic Multidrug Therapies for HIV: Optimal and STI Control Approaches B. M. Adams 1, H. T. Banks and analyzing an optimal control problem using two types of dynamic treatments representing reverse of immune-mediated control of HIV. Our numerical results support a scenario in which STI therapies can lead

79

X-rays Paint a Picture of Picasso's Pigments | Advanced Photon...  

NLE Websites -- All DOE Office Websites (Extended Search)

Breakthrough Protein Structure Could Lead to Better Treatments for HIV, Early Aging The Superpower behind Iron Oxyfluoride Battery Electrodes Science Highlights Archives:...

80

How Serotonin Receptors Can Shape Drug Effects, from LSD to Migraine...  

NLE Websites -- All DOE Office Websites (Extended Search)

Breakthrough Protein Structure Could Lead to Better Treatments for HIV, Early Aging Science Highlights Archives: 2014 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006...

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

Aging and PBX 9502  

SciTech Connect

Components made from PBX 9502, an insensitive high explosive formulated with triaminotrinitrobenzene (TATB) and Kel-F 800 binder, have been in service for nearly two decades. Since that time, samples have been destructively evaluated to determine if potential changes that might affect safety, reliability, or performance have occurred in the high explosive with time. Data from routine, historical testing is reported elsewhere. This paper focuses on specific tests conducted to evaluate the effects of natural aging on handling sensitivity (through the small-scale tests of Human Electrostatic Discharge, friction, and Drop Weight Impact), compressive strength, and thermal ignition. Also reported are the effects of a radiation environment on TATB. Small-scale sensitivity tests show no differences between aged and unaged material. Observed differences in compressive strength behavior are attributed to conditions of original material rather than aging effects. Thermal ignition by flame and laser methods showed no changes between aged and unaged material. Extreme levels of radiation are shown to have only minimal effects in explosive response tests. PBX 9502 is concluded, once again, to be a very stable material, aging gracefully.

Skidmore, C.B.; Idar, D.J.; Buntain, G.A.; Son, S.F.; Sander, R.K.

1998-12-31T23:59:59.000Z

82

Mexico Border HIV Drug abuse  

E-Print Network (OSTI)

Ó The Author(s) 2011. This article is published with open access at Springerlink.com Abstract We examined correlates of ever injecting drugs in Mexico among residents of San Diego, California. From 2007 to 2010, injecting drug users (IDUs) in San Diego underwent an interviewer-administered survey. Logistic regression identified correlates of injection drug use in Mexico. Of 302 IDUs, 38 % were Hispanic, 72 % male and median age was 37; 27 % ever injected in Mexico; 43% reported distributive syringe sharing there. Factors independently associated with ever injecting drugs in Mexico included being younger at first injection, injecting heroin, distributive syringe sharing at least half of the time, and transporting drugs over the last 6 months. One-quarter of IDUs reported ever injecting drugs in Mexico, among whom syringe sharing was common, suggesting possible mixing between IDUs in the Mexico-US border region. Prospective studies should monitor trends in cross-border drug use in light of recent Mexican drug policy reforms partially decriminalizing drug possession.

Tyson Volkmann; Sanghyuk S. Shin; Richard S. Garfein; Irina Artamanova; Steffanie A. Strathdee; T. Volkmann; S. S. Shin; R. S. Garfein; R. A. Pollini; K. D. Wagner; I. Artamanova; S. A. Strathdee; T. L. Patterson

2011-01-01T23:59:59.000Z

83

HEU age determination  

SciTech Connect

A criteria that a sample of highly enriched uranium (HEU) had come from a weapons stockpile and not newly produced in an enrichment plant is to show that the HEU had been produced a significant time in the past. The time since the HEU has produced in an enrichment plant is defined as the age of the HEU in this paper. The HEU age is determined by measuring quantitatively the daughter products {sup 230}Th and {sup 231}Pa of {sup 234}U and {sup 235}U, respectively, by first chemical separation of the thorium and protactinium and then conducting alpha spectrometry of the daughter products.

Moorthy, A.R.; Kato, W.Y.

1994-12-31T23:59:59.000Z

84

Identification of full-length transmitted/founder viruses and their progeny in primary HIV-1 infection  

SciTech Connect

Identification of transmitted/founder virus genomes and their progeny by is a novel strategy for probing the molecular basis of HIV-1 transmission and for evaluating the genetic imprint of viral and host factors that act to constrain or facilitate virus replication. Here, we show in a cohort of twelve acutely infected subjects (9 clade B; 3 clade C), that complete genomic sequences of transmitted/founder viruses could be inferred using single genome amplification of plasma viral RNA, direct amplicon sequencing, and a model of random virus evolution. This allowed for the precise identification, chemical synthesis, molecular cloning, and biological analysis of those viruses actually responsible for productive clinical infection and for a comprehensive mapping of sequential viral genomes and proteomes for mutations that are necessary or incidental to the establishment of HIV-1 persistence. Transmitted/founder viruses were CD4 and CCR5 tropic, replicated preferentially in activated primary T-Iymphocytes but not monocyte-derived macrophages, and were effectively shielded from most heterologous or broadly neutralizing antibodies. By 3 months of infection, the evolving viral quasispecies in three subjects showed mutational fixation at only 2-5 discreet genomic loci. By 6-12 months, mutational fixation was evident at 18-27 genomic loci. Some, but not all, of these mutations were attributable to virus escape from cytotoxic Tlymphocytes or neutralizing antibodies, suggesting that other viral or host factors may influence early HIV -1 fitness.

Korber, Bette [Los Alamos National Laboratory; Hraber, Peter [Los Alamos National Laboratory; Giorgi, Elena [Los Alamos National Laboratory; Bhattacharya, T [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

85

Aging in fragile X syndrome  

E-Print Network (OSTI)

intensified the need for aging studies in FXS. Approximatelywe have surveyed all of the aging patients with FXS that wemedical complications of aging seen in those with FXS. Data

2010-01-01T23:59:59.000Z

86

CD8+ Cell Anti-HIV Activity Rapidly Increases Upon Discontinuation of Early Antiretroviral Therapy  

E-Print Network (OSTI)

S. Killian : J. Roop : S. Ng : F. M. Hecht : J. A. Levy (*)90090-X. 34. Bonneau KR, Ng S, Foster H, et al. DerivationKillian & Jeremy Roop & Sharon Ng & Frederick M. Hecht & Jay

Killian, M. Scott; Roop, Jeremy; Ng, Sharon; Hecht, Frederick M.; Levy, Jay A.

2009-01-01T23:59:59.000Z

87

Aging in community  

E-Print Network (OSTI)

Baby Boomers are on the brink of retirement. According to U.S. Census Bureau projections, the number of people aged 65 and over will more than double in the coming decades, growing from 35 million in 2000 to 72 million in ...

Fay, Justin (Justin Thomas)

2008-01-01T23:59:59.000Z

88

3, 435467, 2007 Gas age-ice age  

E-Print Network (OSTI)

in the ice phase (using volcanic horizons) and in the gas phase (using rapid methane variations). We useCPD 3, 435­467, 2007 Gas age-ice age differences along the EPICA cores L. Loulergue et al. Title of the Past New constraints on the gas age-ice age difference along the EPICA ice cores, 0­50 kyr L. Loulergue

Paris-Sud XI, Université de

89

HIV transcription is induced with some forms of cell killing  

SciTech Connect

Using HeLa cells stably transfected with an HIV-LTR-CAT construct`, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {Gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires function p53, which is missing in HeLa cells. For all other agents, HIV-LTR induction was dose-dependent and correlated with the amount of cell killing that occurred in the culture.

Woloschak, G.E. [Argonne National Lab., IL (United States); Schreck, S. [Argonne National Lab., IL (United States)][South Carolina Univ., Columbia, SC (United States). Dept. of Chemistry; Panozzo, J. [Loyola Univ. Medical Center, Maywood, IL (United States); Chang-Liu, C.-M. [Argonne National Lab., IL (United States); Libertin, C.R. [Loyola Univ. Medical Center, Maywood, IL (United States)

1996-11-01T23:59:59.000Z

90

Invited Article Aging male  

E-Print Network (OSTI)

Now a day, tremendous development of medicine, change of living environment, housing accommodation computer have led to extension of human life expectancy. The population of 60 years old up will increase from 328 millions in years 1990 to 828 millions by years 2020 (united nation, 2001). In Thailand, the aged population will reach 7.6 millions by the year 2010 (11.4 % of total population). In aging male, the incidence of many non communicable diseases is increasing such as metabolic syndrome (DM, dyslipidemia, hypertension, and obesity), coronary heart disease, cerebrovascular disease and disease of endothelial dysfunction. At the same time, the gradual decrease of several hormones, for instance, growth hormone, sex hormone, thyroid hormone; etc, also lead to hormonal imbalance which contributes to

Assoc Prof; Dr. Chanvit Kotheeranurak

2007-01-01T23:59:59.000Z

91

Automatic Age Estimation Based on Facial Aging Patterns  

E-Print Network (OSTI)

Abstract—While recognition of most facial variations, such as identity, expression, and gender, has been extensively studied, automatic age estimation has rarely been explored. In contrast to other facial variations, aging variation presents several unique characteristics which make age estimation a challenging task. This paper proposes an automatic age estimation method named AGES (AGing pattErn Subspace). The basic idea is to model the aging pattern, which is defined as the sequence of a particular individual’s face images sorted in time order, by constructing a representative subspace. The proper aging pattern for a previously unseen face image is determined by the projection in the subspace that can reconstruct the face image with minimum reconstruction error, while the position of the face image in that aging pattern will then indicate its age. In the experiments, AGES and its variants are compared with the limited existing age estimation methods (WAS and AAS) and some well-established classification methods (kNN, BP, C4.5, and SVM). Moreover, a comparison with human perception ability on age is conducted. It is interesting to note that the performance of AGES is not only significantly better than that of all the other algorithms, but also comparable to that of the human observers. Index Terms—Computer vision, pattern recognition, machine learning, face and gesture recognition, age estimation. 1

Xin Geng; Zhi-hua Zhou; Senior Member; Kate Smith-miles; Senior Member

2007-01-01T23:59:59.000Z

92

The Age of the Universe  

E-Print Network (OSTI)

Globular clusters are the oldest objects in the Galaxy whose age may be accurately determined. As such globular cluster ages provide the best estimate for the age of the universe. The age of a globular cluster is determined by a comparison between theoretical stellar evolution models and observational data. Current uncertainties in the stellar models and age dating process are discussed in detail. The best estimate for the absolute age of the globular clusters is $14.6\\pm 1.7\\,$Gyr. The one-sided, 95\\% confidence limit on the lower age of the universe is $12.2\\,$Gyr.

Brian Chaboyer

1996-05-16T23:59:59.000Z

93

THE EARLY LIFE HISTORY OF SKIPJACK TUNA, Katsuwonus pelamis, IN THE PACIFIC OCEAN  

E-Print Network (OSTI)

THE EARLY LIFE HISTORY OF SKIPJACK TUNA, Katsuwonus pelamis, IN THE PACIFIC OCEAN HOWARD O. YOSHIDA' ABSTRAcr This study investigates the early life history of skipjack tuna, including the distribution, abundance, age, and growth. The study is based on 1,742 juvenile skipjack tuna that were found

94

LANL researchers use computer modeling to study HIV | National Nuclear  

National Nuclear Security Administration (NNSA)

researchers use computer modeling to study HIV | National Nuclear researchers use computer modeling to study HIV | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > LANL researchers use computer modeling to study HIV LANL researchers use computer modeling to study HIV Posted By Office of Public Affairs Los Alamos National Laboratory researchers are investigating the complex

95

Decision making in the HIV/AIDS supply chain  

E-Print Network (OSTI)

During the first two decades of HIV/AIDS awareness, the U.S. and foreign governments responded slowly to the crisis. In contrast today, as the pandemic continues, initiatives of nonprofit organizations have dramatically ...

Cao, Elaine Phu

2007-01-01T23:59:59.000Z

96

HIV antiretroviral therapy in resource-limited settings: Experiences ...  

Science Conference Proceedings (OSTI)

people with HIV/AIDS in the world live in resource-poor settings [2•]. Since the .... The choice of the three drugs used in the first-line regi- .... Field work- ers have ...

97

Neutrons' view of hydrogen yields insight into HIV drug design...  

NLE Websites -- All DOE Office Websites (Extended Search)

Neutrons' view of hydrogen yields insight into HIV drug design ORNL-led study demonstrates relevance of neutrons in biomedical research An ORNL-led team used neutrons to study the...

98

Systematic Dissection of the Determinants of HIV Expression Noise  

E-Print Network (OSTI)

performed using the EpiQ Chromatin Analysis Kit (Bio-Rad) asby qPCR using the EpiQ Chromatin SYBR Supermix (Bio-Rad).used to quantify the chromatin density at the HIV promoter:

Foley, Jonathan Emmett

2013-01-01T23:59:59.000Z

99

How HIV infects cells | Argonne National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Science Science Computing, Environment & Life Sciences Energy Engineering & Systems Analysis Photon Sciences Physical Sciences & Engineering Energy Frontier Research Centers Science Highlights Postdoctoral Researchers The brightness and energy of X-ray beams are critical properties for research. The APS Upgrade will make our X-ray beams brighter, meaning more X-rays can be focused onto a smaller, laser-like spot, allowing researchers to gather more data in greater detail in less time. How HIV infects cells October 10, 2013 Tweet EmailPrint In a long-awaited finding, an international team of scientists using high-brightness x-rays from the U.S. Department of Energy Office of Science's Advanced Photon Source at Argonne National Laboratory has determined the high-resolution atomic structure of a cell-surface receptor

100

The Universe Adventure - Early Models  

NLE Websites -- All DOE Office Websites (Extended Search)

Early Models of the Universe Ready for Blast-off Space exploration missions contribute greatly to our understanding of the Universe. With our new understanding of the fundamental...

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101

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or other carbonaceous feedstock. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Testing Plan (RD and T) for implementation in Phase II. The objective of Phase II is to implement the RD and T as outlined in the Phase I RD and T Plan to enhance the development and commercial acceptance of coproduction technology that produces high-value products, particularly those that are critical to our domestic fuel and power requirements. The project will resolve critical knowledge and technology gaps on the integration of gasification and downstream processing to coproduce some combination of power, fuels, and chemicals from coal and other feedstocks. The objective of Phase III is to develop an engineering design package and a financing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information that will be needed to move the EECP forward to detailed design, construction, and operation by industry.

John S. Abughazaleh; Mushtaq Ahmed; Ashok Anand; John H. Anderson; Charles Benham; Fred D. Brent; Thomas E. Chance; William K. Davis; Raymond F. Drnevich; Larry Hall; Ming He; Stephen A. Lang; Jimmy O. Ong; Sarah J. Patel; George Potoczniak; Adela G. Sanchez; Charles H. Schrader; Lalit S. Shah; Phil J. Shires; Rae Song

2000-10-26T23:59:59.000Z

102

EARLY ENTRANCE COPRODUCTION PLANT  

Science Conference Proceedings (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal or coal in combination with some other carbonaceous feedstock. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Test Plan (RD and T) for implementation in Phase II. The objective of Phase II is to conduct RD and T as outlined in the Phase I RD and T Plan to enhance the development and commercial acceptance of Coproduction technology that produces high-value products, particularly those that are critical to our domestic fuel and power requirements. The project will resolve critical knowledge and technology gaps on the integration of gasification and downstream processing to coproduce some combination of power, fuels, and chemicals from coal and other feedstocks. The objective of Phase III is to develop an engineering design package and a financing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information that will be needed to move the EECP forward to detailed design, construction, and operation by industry.

Lalit S. Shah; William K. Davis

2000-05-01T23:59:59.000Z

103

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect

The overall objective of this project is the three-phase development of an Early Entrance Coproduction Plant (EECP) that produces at least one product from at least two of the following three categories: Electric power (or heat); Fuels; and Chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or some other carbonaceous feedstock, such as petroleum coke. The objective of Phase I was to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Testing (RD and T) Plan for implementation in Phase II. This objective has now been accomplished. A specific site, Motiva Refinery in Port Arthur, Texas, has been selected as the location best suited for the EECP. The accomplishments of Phase I are discussed in detail in this Phase I Concept Report. A RD and T Plan and a preliminary project financing plan have been developed and are submitted separately from this report.

John S. Abughazaleh; Mushtaq Ahmed; Ashok Anand; John H. Anderson; Charles Benham; Fred D. Brent; Thomas E. Chance; William K. Davis; Raymond F. Drnevich; Larry Hall; Ming He; Stephen A. Lang; David Mintner; Wendy Moore; Jimmy O. Ong; George Potoczniak; Adela G. Sanchez; Charles H. Schrader; Lalit S. Shah; Kalapi D. Sheth; Phil J. Shires; Rae Song

2001-05-17T23:59:59.000Z

104

Aging and the labor market  

E-Print Network (OSTI)

This thesis is a collection of three essays analyzing the interplay between aging and the labor market. The first chapter demonstrates that differential treatment by age exists in labor markets and explores different ...

Lahey, Joanna

2005-01-01T23:59:59.000Z

105

HIV mortality in urban slums of Nairobi, Kenya 2003ż2010: a period effect analysis  

E-Print Network (OSTI)

Abstract Background It has been almost a decade since HIV was declared a national disaster in Kenya. Antiretroviral therapy (ART) provision has been a mainstay of HIV treatment efforts globally. In Kenya, the government started ART provision in 2003...

Oti, Samuel O; Mutua, Michael; Mgomella, George S; Egondi, Thaddaeus; Ezeh, Alex; Kyobutungi, Catherine

2013-06-17T23:59:59.000Z

106

Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens  

DOE Patents (OSTI)

The present invention relates to mosaic clade M HIV-1 Env polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Korber, Bette T. (Los Alamos, NM); Fischer, William (Los Alamos, NM); Liao, Hua-Xin (Durham, NC); Haynes, Barton F. (Durham, NC); Letvin, Norman (Boston, MA); Hahn; Beatrice H. (Birmingham, AL)

2011-05-31T23:59:59.000Z

107

Retinal Diseases: Age-Related Macular Degeneration and Retinitis Pigmentosa  

NLE Websites -- All DOE Office Websites (Extended Search)

Retinal Diseases: Age-Related Macular Degeneration and Retinitis Pigmentosa Retinal Diseases: Age-Related Macular Degeneration and Retinitis Pigmentosa Age-related macular degeneration (AMD) is an eye disease primarily affecting the central vision regions in people age 60 and older. According to the Macular Degeneration Research Fund, a case of AMD is diagnosed in the United States every 3 minutes. Each year, 1.2 million of the estimated 12 million people with AMD will suffer severe vision loss. Patients with AMD have dark areas in their vision caused by fluid leakage or bleeding in the macula, the center of the retina that produces the sharpest vision. The brain initially compensates for these dark patches. Early cellular dysfunction or spotting in the macula may go undetected until the disease is in advanced stages.

108

AEO2013 Early Release Overview  

Gasoline and Diesel Fuel Update (EIA)

3 Early Release Overview 3 Early Release Overview AEO2013 Early Release Overview Executive summary Projections in the Annual Energy Outlook 2013 (AEO2013) Reference case focus on the factors that shape U.S. energy markets through 2040, under the assumption that current laws and regulations remain generally unchanged throughout the projection period. This early release focuses on the AEO2013 Reference case, which provides the basis for examination and discussion of energy market trends and serves as a starting point for analysis of potential changes in U.S. energy policies, rules, or regulations or potential technology breakthroughs. Readers are encouraged to review the full range of cases that will be presented when the complete AEO2013 is released in early 2013, exploring key uncertainties in the Reference case. Major highlights in the AEO2013 Reference case include:

109

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, Inc., GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. During Phase I, a design basis for the Fischer-Tropsch Synthesis section was developed based on limited experience with the specified feed gas and operating conditions. The objective of this Task in Phase II RD&T work was to confirm the performance of the F-T reactor at the set design conditions. Although much of the research, development, and testing work were done by TES outside of this project, several important issues were addressed in this phase of the project. They included Rejuvenation/Regeneration of the Fischer-Tropsch Catalyst, online Catalyst Withdrawal and Addition from the synthesis reactor, and the Fischer-Tropsch Design Basis Confirmation. In Phase III the results from these RD&T work will be incorporated in developing the engineering design package. This Topical Report documents the Phase II RD&T work that was completed for this task.

David Storm; Govanon Nongbri; Steve Decanio; Ming He; Lalit Shah; Charles Schrader; Earl Berry; Peter Ricci; Belma Demirel; Charles Benham; Mark Bohn

2004-01-12T23:59:59.000Z

110

EARLY ENTRANCE COPRODUCTION PLANT  

DOE Green Energy (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems was assessed for technical risks and barriers. A plan was developed to mitigate the identified risks (Phase II RD&T Plan, October 2000). The potential technical and economic risks to the EECP from Task 2.5 can be mitigated by demonstrating that the end-use products derived from the upgrading of the F-T synthesis total liquid product can meet or exceed current specifications for the manufacture of ethylene and propylene chemicals from F-T naphtha, for the generation of hydrogen from F-T naphtha to power fuel cells, for direct blending of F-T diesels into transportation fuels, for the conversion of F-T heavy product wax to transportation fuels, and the conversion of F-T Heavy product wax to a valuable high melting point food-grade specialty wax product. Product evaluations conducted under Task 2.5 of Phase II successfully mitigated the above technical and economic risks to the EECP with the development of product yields and product qualities for the production of chemicals, transportation fuels, and specialty food-grade waxes from the F-T synthesis products.

Fred D. Brent; Lalit Shah; Earl Berry; Charles H. Schrader; John Anderson; Ming He; James F. Stevens; Centha A. Davis; Michael Henley; Jerome Mayer; Harry Tsang; Jimell Erwin; Jennifer Adams; Michael Tillman; Chris Taylor; Marjan J. Roos; Robert F. Earhart

2004-01-27T23:59:59.000Z

111

Kinetics of PBX9404 Aging  

DOE Green Energy (OSTI)

PBX 9404 is an early formulation of HMX from which we can learn about the effects of aging in the weapons stockpile. Of particular interest is the presence of 3% nitrocellulose in PBX 9404 as an energetic binder. Nitrocellulose is used pervasively in smokeless gunpowders and was formerly used extensively in the film and art preservation industries. It is well known that nitrocellulose decomposes autocatalytically, and stabilizers, such as the diphenylamine used in PBX 9404, are used to retard its decomposition. Even so, its lifetime is still limited, and the reactions eventually leading to catastrophic autocatalysis are still not understood well despite years of work. In addition to reducing the available energy in the explosive, degradation of nitrocellulose affects the mechanical properties of the pressed PBX 9404 parts by the associated reduction in molecular weight, which reduces the strength of the binder. A structural formula for a monomer of the nitrocellulose used in PBX 9404 is shown. The initial nitration level is 2.3 of 3.0 possible sites, and they have different reactivities. Degradation of nitrocellulose affects many properties. As an aid in examining historical chemical analysis data, several measures of degradation are given for the simple replacement of a nitro group with a hydrogen. The weight percent of nitrocellulose remaining for an initial concentration of 3% as used in PBX 9404 is also given. Of course, the real degradation reaction is more complicated, including chain scission and crosslinking reactions giving other gas species. During the course of this work, we spent considerable time addressing the question, ''Why is PBX 9404 blue?'' There was actually considerable controversy in the color evolution with aging, and the situation was clarified by Ben Richardson at Pantex. Workers there assured us that PBX 9404 starts with an ivory color. Drying the prill prior to pressing turns it a mottled blue, and well-preserved prill samples retain a blue color decades after formulation. Subsequently, heat and light both send it through a progression of colors from grayish blue, blue-green, green, brown, dirty yellow, mottled tan, and eventually pale tan. The progression is accelerated by oxygen and possibly moisture, as has been shown in several accelerated aging studies. The precise compounds causing the color evolution are uncertain, but they are undoubtedly a progression of quinoidal, nitroso, and nitrated DPA compounds. For example, paranitroso DPA is deep blue. Unfortunately, the location of various nitrated DPAs, which ranged from yellow to orange to red to brown and which were used by Pantex as analytical standards in the 1970s, is not currently known. While the color change is indicative of aging, it is by no means a quantitative measure of the extent of nitrocellulose degradation. Inspection of the literature yielded a variety of kinetic models, and the activation energy typically ranges from 25-35 kcal/mol for T<100 C. This literature qualitatively predicts times for 30% decomposition ranging from a few days at 100 C to 1-2 years at 50 C to 50 years at room temperature. To develop a quantitative model, we used the data of Leider and Seaton, which were collected at conditions most closely matching stockpile conditions for any data set we had available. They used PBX 9404 heated as pressed pellets in closed vessels at temperatures ranging from 50 to 100 C for times up to three years, and they report mass loss, gas yield and composition, and chemical analysis of the residual solid by methods used in stockpile surveillance. Initial kinetic analysis of the weight of remaining nitrocellulose as measured by liquid chromatography and the loss of nitrate esters by a colorimetric technique gave an activation energy of 27 kcal/mol. However, the reaction is complex due to the different stability of the three nitroester positions, and this complexity required either parallel first-order reactions or an nth-order reaction (n=3.6), which is mathematically equivalent to a Gamma distribution of frequency factors

Burnham, A K; Fried, L E

2006-09-11T23:59:59.000Z

112

Recycling came of age in 1994  

SciTech Connect

While metal and glass recycling have a long history, newer recycling efforts for paper and plastic have gone from a nascent business to maturing industry. After five years, sufficient infrastructure exists to support recycling as a full-fledged business. In the late 1980s, recycling was a business trying to get off the ground. Now it is recognized by many cities and states as a means of economic development and job creation. But recycling`s coming of age was not without growing pains. Many recyclers had to hang on while markets were poor and spotty. Gluts of plastic, waste paper, aluminum, and green glass often made it difficult for recyclers to turn a profit. Until early 1994, prices for most commodities were significantly low, and in some cases, these low prices forced recyclers and processors to close their doors, or at least curtail their operations.

Rabasca, L.

1995-04-01T23:59:59.000Z

113

Aging and functional brain networks  

SciTech Connect

Aging is associated with changes in human brain anatomy and function and cognitive decline. Recent studies suggest the aging decline of major functional connectivity hubs in the 'default-mode' network (DMN). Aging effects on other networks, however, are largely unknown. We hypothesized that aging would be associated with a decline of short- and long-range functional connectivity density (FCD) hubs in the DMN. To test this hypothesis, we evaluated resting-state data sets corresponding to 913 healthy subjects from a public magnetic resonance imaging database using functional connectivity density mapping (FCDM), a voxelwise and data-driven approach, together with parallel computing. Aging was associated with pronounced long-range FCD decreases in DMN and dorsal attention network (DAN) and with increases in somatosensory and subcortical networks. Aging effects in these networks were stronger for long-range than for short-range FCD and were also detected at the level of the main functional hubs. Females had higher short- and long-range FCD in DMN and lower FCD in the somatosensory network than males, but the gender by age interaction effects were not significant for any of the networks or hubs. These findings suggest that long-range connections may be more vulnerable to aging effects than short-range connections and that, in addition to the DMN, the DAN is also sensitive to aging effects, which could underlie the deterioration of attention processes that occurs with aging.

Tomasi D.; Tomasi, D.; Volkow, N.D.

2011-07-11T23:59:59.000Z

114

EARLY ENTRANCE COPRODUCTION PLANT  

Science Conference Proceedings (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. During Phase I the team identified several potential methods to reduce or minimize the environmental impact of the proposed EECP. The EECP Project Team identified F-T catalyst disposal, beneficial gasifier slag usage (other than landfill), and carbon dioxide recovery for the gas turbine exhaust for study under this task. Successfully completing the Task 2.10 RD&T provides additional opportunities for the EECP to meet the goals of DOE's Vision 21 Program. The gasification section offers several opportunities to maximize the environmental benefits of an EECP. The spent F-T catalyst can be sent to landfills or to the gasification section. Testing in Phase II shows that the spent F-T catalyst with a small wax coating can safely meet federal landfill requirements. As an alternative to landfilling, it has been proposed to mix the spent F-T catalyst with the petroleum coke and feed this mixture to the gasification unit. Based on ChevronTexaco's experience with gasification and the characteristics of the spent F-T catalyst this appears to be an excellent opportunity to reduce one potential waste stream. The slag from the gasification unit can be commercially marketed for construction or fuel (such as cement kiln fuel) uses. The technical and economic benefits of these options must be reviewed for the final EECP before incorporating a specific alternative into the design basis. Reducing greenhouse gas emissions, particularly carbon dioxide, is an important goal of the EECP. The Texaco gasification process provides opportunities to capture high purity streams of carbon dioxide. For Phase II, a carbon fiber composite molecular sieve (CFCMS) was tested to determine its potential to remove high purity carbon dioxide from the exhaust of a gas turbine. Testing on with a simulated gas turbine exhaust shows that the CFCMS is able to remove high purity carbon dioxide from the exhaust. However, more development is required to optimize the system.

John H. Anderson; Charles Benham; Earl R. Berry; Ming He; Charles H. Schrader; Lalit S. Shah; O.O. Omatete; T.D. Burchell

2004-01-12T23:59:59.000Z

115

THE EARLY EARLY TYPE: DISCOVERY OF A PASSIVE GALAXY AT z{sub spec} {approx} 3  

SciTech Connect

We present the discovery of a massive, quiescent galaxy at z = 2.99. We have obtained an Hubble Space Telescope WFC3 spectrum of this object and measured its redshift from the detection of a deep 4000 A break consistent with an old population and a high metallicity. By stellar population modeling of both its grism spectrum and broadband photometry, we derive an age of {approx}0.7 Gyr, implying a formation redshift of z > 4, and a mass >10{sup 11} M{sub Sun }. Although this passive galaxy is the most distant confirmed so far, we find that it is slightly less compact than other z > 2 early types of similar mass, being overall more analogous to those z {approx} 1.6 field early-type galaxies. The discovery of this object shows that early-type galaxies are detectable to at least z = 3 and suggests that the diversity of structural properties found in z = 1.4-2 ellipticals to earlier epochs could have its origin in a variety of formation histories among their progenitors.

Gobat, R.; Strazzullo, V.; Daddi, E.; Bethermin, M. [Laboratoire AIM-Paris-Saclay, CEA/DSM-CNRS, Universite Paris Diderot, Irfu/Service d'Astrophysique, CEA Saclay, Orme des Merisiers, F-91191 Gif sur Yvette (France); Onodera, M.; Carollo, M. [Institute for Astronomy, ETH Zuerich Wolfgang-Pauli-strasse 27, CH-8093 Zuerich (Switzerland); Renzini, A. [INAF, Osservatorio Astronomico di Padova Vicolo dell'Osservatorio 5, I-35122 Padova (Italy); Dickinson, M. [National Optical Astronomy Observatory, P.O. Box 26732, Tucson, AZ 85726 (United States); Cimatti, A. [Dipartimento di Astronomia, Universita di Bologna, Via Ranzani 1, I-40127 Bologna (Italy)

2012-11-10T23:59:59.000Z

116

AEO2014 Early Release Overview  

U.S. Energy Information Administration (EIA) Indexed Site

Administration | Annual Energy Outlook 2014 Early Release Overview Administration | Annual Energy Outlook 2014 Early Release Overview AEO2014 Early Release Overview Executive summary Projections in the Annual Energy Outlook 2014 (AEO2014) Reference case focus on the factors that shape U.S. energy markets through 2040, under the assumption that current laws and regulations remain generally unchanged throughout the projection period. The early release provides a basis for the examination and discussion of energy market trends and serves as a starting point for analysis of potential changes in U.S. energy policies, rules, or regulations or possible technology breakthroughs. Readers are encouraged to review the full range of cases that will be presented when the complete AEO2014 is released in 2014, exploring key

117

AEO2012 Early Release Overview  

Gasoline and Diesel Fuel Update (EIA)

AEO2012 Early Release Overview Total U.S. consumption of liquid fuels, including both fossil fuels and biofuels, grows from 37.2 quadrillion Btu (19.2 million barrels per day)...

118

Early lunar geology and geophysics  

E-Print Network (OSTI)

Despite a number of human and robotic missions to the Moon, there are still important unanswered questions about its early evolution, and how it came to be the object we observe today. Here we use observational, experimental, ...

Garrick-Bethell, Ian, 1980-

2009-01-01T23:59:59.000Z

119

Accelerated Aging of Roofing Surfaces  

NLE Websites -- All DOE Office Websites (Extended Search)

Ohio CRRC, Arizona CRRC, Florida CRRC, Ohio 6 | Building Technologies Office eere.energy.gov Approach: develop accelerated aging method Accelerated soiling (atmospheric...

120

Understanding aging issues in Indonesia.  

E-Print Network (OSTI)

??This study used combined methods of observations, interviews and document analysis to understand issues related to aging in Indonesia. The study describes relevant policy and… (more)

Napsiyah, Siti.

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

EARLY ENTRANCE COPRODUCTION PLANT  

SciTech Connect

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems were assessed for technical risks and barriers. A plan was identified to mitigate the identified risks (Phase II RD&T Plan, October 2000). The RD&T Plan identified petroleum coke characteristics as a potential technical risk. The composition of petroleum coke varies from one refinery to another. Petroleum coke characteristics are a function of the crude oil slate available at the refinery and the coker operating parameters. The specific petroleum coke characteristics at a refinery affect the design of the Gasification and Acid Gas Removal (AGR) subsystems. Knowing the petroleum coke composition provides the necessary data to proceed to the EECP Phase III engineering design of the gasification process. Based on ChevronTexaco's experience, the EECP team ranked the technical, economic, and overall risks of the petroleum coke composition related to the gasification subsystem as low. In Phase I of the EECP Project, the Motiva Port Arthur Refinery had been identified as the potential EECP site. As a result of the merger between Texaco and Chevron in October 2001, Texaco was required to sell its interest in the Motiva Enterprises LLC joint venture to Shell Oil Company and Saudi Refining Inc. To assess the possible impact of moving the proposed EECP host site to a ChevronTexaco refinery, samples of petroleum coke from two ChevronTexaco refineries were sent to MTC for bench-scale testing. The results of the analysis of these samples were compared to the Phase I EECP Gasification Design Basis developed for Motiva's Port Arthur Refinery. The analysis confirms that if the proposed EECP is moved to a new refinery site, the Phase I EECP Gasification Design Basis would have to be updated. The lower sulfur content of the two samples from the ChevronTexaco refineries indicates that if one of these sites were selected, the Sulfur Recovery Unit (SRU) might be sized smaller than the current EECP design. This would reduce the capital expense of the SRU. Additionally, both ChevronTexaco samples have a higher hydrogen to carbon monoxide ratio than the Motiva Port Arthur petroleum coke. The higher hydrogen to carbon monoxide ratio could give a slightly higher F-T products yield from the F-T Synthesis Reactor. However, the EECP Gasification Design Basis can not be updated until the site for the proposed EECP site is finalized. Until the site is finalized, the feedstock (petroleum coke) characteristics are a low risk to the EECP project.

Abdalla H. Ali; John H. Anderson; Earl R. Berry; Charles H. Schrader; Lalit S. Shah

2003-04-16T23:59:59.000Z

122

EARLY ENTRANCE COPRODUCTION PLANT  

DOE Green Energy (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems was assessed for technical risks and barriers. A plan was developed to mitigate the identified risks (Phase II RD&T Plan, October 2000). Phase II RD&T Task 2.6 identified as potential technical risks to the EECP the fuel/engine performance and emissions of the F-T diesel fuel products. Hydrotreating the neat F-T diesel product reduces potentially reactive olefins, oxygenates, and acids levels and alleviates corrosion and fuel stability concerns. Future coproduction plants can maximize valuable transportation diesel by hydrocracking the F-T Synthesis wax product to diesel and naphtha. The upgraded neat F-T diesel, hydrotreater F-T diesel, and hydrocracker F-T diesel products would be final blending components in transportation diesel fuel. Phase II RD&T Task 2.6 successfully carried out fuel lubricity property testing, fuel response to lubricity additives, and hot-start transient emission tests on a neat F-T diesel product, a hydrocracker F-T diesel product, a blend of hydrotreater and hydrocracker F-T diesel products, and a Tier II California Air Resources Board (CARB)-like diesel reference fuel. Only the neat F-T diesel passed lubricity inspection without additive while the remaining three fuel candidates passed with conventional additive treatment. Hot-start transient emission tests were conducted on the four fuels in accordance with the U.S. Environmental Protection Agency (EPA) Federal Test Procedure (FTP) specified in Code of Federal Regulations, Title 40, Part 86, and Subpart N on a rebuilt 1991 Detroit Diesel Corporation Series 60 heavy-duty diesel engine. Neat F-T diesel fuel reduced oxides of nitrogen (NO{sub x}), total particulate (PM), hydrocarbons (HC), carbon monoxide (CO), and the Soluble Organic Fraction (SOF) by 4.5%, 31%, 50%, 29%, and 35%, respectively, compared to the Tier II CARB-like diesel. The hydrocracker F-T diesel product and a blend of hydrocracker and hydrotreater F-T diesel products also reduced NO{sub x}, PM, HC, CO and SOF by 13%, 16% to 17%, 38% to 63%, 17% to 21% and 21% to 39% compared to the Tier II CARB-like diesel. The fuel/engine performance and emissions of the three F-T diesel fuels exceed the performance of a Tier II CARB-like diesel. Phase II RD&T Task 2.6 successfully met the lubricity property testing and F-T diesel fuel hot-start transient emissions test objectives. The results of the testing help mitigate potential economic risks on obtaining a premium price for the F-T diesel fuel

Fred D. Brent; Lalit Shah; Earl Berry; Charles H. Schrader; John Anderson; J. Erwin; Matthew G. Banks; Terry L. Ullman

2004-01-12T23:59:59.000Z

123

EARLY ENTRANCE COPRODUCTION PLANT  

Science Conference Proceedings (OSTI)

The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems was assessed for technical risks and barriers. A plan was developed to mitigate the identified risks (Phase II RD&T Plan, October 2000). Phase II RD&T Task 2.6 identified as potential technical risks to the EECP the fuel/engine performance and emissions of the F-T diesel fuel products. Hydrotreating the neat F-T diesel product reduces potentially reactive olefins, oxygenates, and acids levels and alleviates corrosion and fuel stability concerns. Future coproduction plants can maximize valuable transportation diesel by hydrocracking the F-T Synthesis wax product to diesel and naphtha. The upgraded neat F-T diesel, hydrotreater F-T diesel, and hydrocracker F-T diesel products would be final blending components in transportation diesel fuel. Phase II RD&T Task 2.6 successfully carried out fuel lubricity property testing, fuel response to lubricity additives, and hot-start transient emission tests on a neat F-T diesel product, a hydrocracker F-T diesel product, a blend of hydrotreater and hydrocracker F-T diesel products, and a Tier II California Air Resources Board (CARB)-like diesel reference fuel. Only the neat F-T diesel passed lubricity inspection without additive while the remaining three fuel candidates passed with conventional additive treatment. Hot-start transient emission tests were conducted on the four fuels in accordance with the U.S. Environmental Protection Agency (EPA) Federal Test Procedure (FTP) specified in Code of Federal Regulations, Title 40, Part 86, and Subpart N on a rebuilt 1991 Detroit Diesel Corporation Series 60 heavy-duty diesel engine. Neat F-T diesel fuel reduced oxides of nitrogen (NO{sub x}), total particulate (PM), hydrocarbons (HC), carbon monoxide (CO), and the Soluble Organic Fraction (SOF) by 4.5%, 31%, 50%, 29%, and 35%, respectively, compared to the Tier II CARB-like diesel. The hydrocracker F-T diesel product and a blend of hydrocracker and hydrotreater F-T diesel products also reduced NO{sub x}, PM, HC, CO and SOF by 13%, 16% to 17%, 38% to 63%, 17% to 21% and 21% to 39% compared to the Tier II CARB-like diesel. The fuel/engine performance and emissions of the three F-T diesel fuels exceed the performance of a Tier II CARB-like diesel. Phase II RD&T Task 2.6 successfully met the lubricity property testing and F-T diesel fuel hot-start transient emissions test objectives. The results of the testing help mitigate potential economic risks on obtaining a premium price for the F-T diesel fuel

Fred D. Brent; Lalit Shah; Earl Berry; Charles H. Schrader; John Anderson; J. Erwin; Matthew G. Banks; Terry L. Ullman

2004-01-12T23:59:59.000Z

124

Early Science Program | Argonne Leadership Computing Facility  

NLE Websites -- All DOE Office Websites (Extended Search)

Early Science Program The goals of the Early Science Program (ESP) were to prepare key applications for the architecture and scale of Mira, and to solidify libraries and...

125

Compare Activities by Building Age  

U.S. Energy Information Administration (EIA) Indexed Site

Activities by Building Age Activities by Building Age Compare Activities by ... Building Age Median Age of Building by Building Type Vacant buildings, retail stores (other than malls), and religious worship buildings tended to be the oldest buildings. Food sales buildings (which were predominantly convenience stores) and outpatient health care buildings were mainly newer buildings. Figure showing median age of building by building type. If you need assistance viewing this page, please call 202-586-8800. Specific questions may be directed to: Joelle Michaels joelle.michaels@eia.doe.gov CBECS Manager Release date: July 24, 2002 Page last modified: May 4, 2009 2:52 PM http://www.eia.gov/consumption/commercial/data/archive/cbecs/pba99/compareage.html If you are having any technical problems with this site, please contact the EIA

126

The Age of the Universe  

E-Print Network (OSTI)

A minimum age of the universe can be estimated directly by determining the age of the oldest objects in the our Galaxy. These objects are the metal-poor stars in the halo of the Milky Way. Recent work on nucleochronology finds that the oldest stars are 15.2+/-3.7 Gyr old. White dwarf cooling curves have found a minimum age for the oldest stars of 8 Gyr. Currently, the best estimate for the age of the oldest stars is based upon the absolute magnitude of the main sequence turn-off in globular clusters. The oldest globular clusters are 11.5+/-1.3 Gyr old, implying a minimum age of the universe of t_universe > 9.5 Gyr (95% confidence level).

Brian Chaboyer

1998-08-19T23:59:59.000Z

127

Light Water Reactor Sustainability Program: Materials Aging and Degradation  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Materials Aging and Materials Aging and Degradation Technical Program Plan Light Water Reactor Sustainability Program: Materials Aging and Degradation Technical Program Plan Components serving in a nuclear reactor plant must withstand a very harsh environment including extended time at temperature, neutron irradiation, stress, and/or corrosive media. The many modes of degradation are complex and vary depending on location and material. However, understanding and managing materials degradation is a key for the continued safe and reliable operation of nuclear power plants. Extending reactor service to beyond 60 years will increase the demands on materials and components. Therefore, an early evaluation of the possible effects of extended lifetime is critical. The recent NUREG/CR-6923 gives a

128

The Aging Workforce and Paid Time Off  

E-Print Network (OSTI)

The Aging Workforce and Paid Time Off Draft 07/08/09 Gilliana matter of the workforce aging as the population ages. Thephysical changes with aging that can affect performance. 10

Lester, Gillian

2009-01-01T23:59:59.000Z

129

Transportation, Aging and Disposal Canister System Performance...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Transportation, Aging and Disposal Canister System Performance Specification: Revision 1 Transportation, Aging and Disposal Canister System Performance Specification: Revision 1...

130

Gentrifying geriatrics : challenging design paradigms for the aged and aging  

E-Print Network (OSTI)

Internationally the world is undergoing a grey revolution, with the average age of the human population being higher than it has ever been before. Within the U.S. context this trend is driven by the Baby Boomers, the 80 ...

Van der Linde, Gerhard J. (Gerhard Johan)

2011-01-01T23:59:59.000Z

131

AGING FACILITY CRITICALITY SAFETY CALCULATIONS  

Science Conference Proceedings (OSTI)

The purpose of this design calculation is to revise and update the previous criticality calculation for the Aging Facility (documented in BSC 2004a). This design calculation will also demonstrate and ensure that the storage and aging operations to be performed in the Aging Facility meet the criticality safety design criteria in the ''Project Design Criteria Document'' (Doraswamy 2004, Section 4.9.2.2), and the functional nuclear criticality safety requirement described in the ''SNF Aging System Description Document'' (BSC [Bechtel SAIC Company] 2004f, p. 3-12). The scope of this design calculation covers the systems and processes for aging commercial spent nuclear fuel (SNF) and staging Department of Energy (DOE) SNF/High-Level Waste (HLW) prior to its placement in the final waste package (WP) (BSC 2004f, p. 1-1). Aging commercial SNF is a thermal management strategy, while staging DOE SNF/HLW will make loading of WPs more efficient (note that aging DOE SNF/HLW is not needed since these wastes are not expected to exceed the thermal limits form emplacement) (BSC 2004f, p. 1-2). The description of the changes in this revised document is as follows: (1) Include DOE SNF/HLW in addition to commercial SNF per the current ''SNF Aging System Description Document'' (BSC 2004f). (2) Update the evaluation of Category 1 and 2 event sequences for the Aging Facility as identified in the ''Categorization of Event Sequences for License Application'' (BSC 2004c, Section 7). (3) Further evaluate the design and criticality controls required for a storage/aging cask, referred to as MGR Site-specific Cask (MSC), to accommodate commercial fuel outside the content specification in the Certificate of Compliance for the existing NRC-certified storage casks. In addition, evaluate the design required for the MSC that will accommodate DOE SNF/HLW. This design calculation will achieve the objective of providing the criticality safety results to support the preliminary design of the Aging Facility. As the ongoing design evolution remains fluid, the results from this design calculation should be evaluated for applicability to any new or modified design. Consequently, the results presented in this document are limited to the current design. The information contained in this document was developed by Environmental and Nuclear Engineering and is intended for the use of Design and Engineering in its work regarding the various criticality related activities performed in the Aging Facility. Yucca Mountain Project personnel from Environmental and Nuclear Engineering should be consulted before the use of the information for purposes other than those stated herein or use by individuals other than authorized personnel in Design and Engineering.

C.E. Sanders

2004-09-10T23:59:59.000Z

132

Aging and the prostate gland  

NLE Websites -- All DOE Office Websites (Extended Search)

Aging and the prostate gland Name: Bobby Lee Location: NA Country: NA Date: NA Question: It seems that as males get older, it takes longer for them to begin urination. Why is...

133

Plants of the Coal Age  

NLE Websites -- All DOE Office Websites (Extended Search)

Coal Age Nature Bulletin No. 330-A February 1, 1969 Forest Preserve District of Cook County George W. Dunne, President Roland F. Eisenbeis, Supt. of Conservation PLANTS OF THE COAL...

134

The age of the universe  

Science Conference Proceedings (OSTI)

An overview of the current controversy on the age of the universe is presented. It is shown that the age of the oldest star, globular clusters, yields an age estimate of approximately 14 {+-} 2 {+-} 2 Gyr (where the first {+-} is statistical and the second systematic, and the two should {ital not} be added in quadrature), with a firm lower bound of {ge} 10 Gyr. It is shown how radioactive dating, nucleocosmochronology, also yields a firm lower bound of {approx_gt} 10 Gyr. The currently favored values for the Hubble constant, when converted to ages using a cosmological model with zero cosmological constant, are shown {ital not} to be in conflict with statistical and systematic uncertainties at the present time when one takes both into account, even for critical density universes. 25 refs. , 3 figs., 1 tab.

Schramm, D.N.

1996-10-01T23:59:59.000Z

135

Control Relay Aging Management Guideline  

Science Conference Proceedings (OSTI)

The concept for this report came from the concern that many control relays have been in service for an extended period of time and an effective aging management program may not be in place for these relays. In addition, recent Institute of Nuclear Power Operations (INPO) data indicate that relays are one of the leading component types causing scrams. With control relay age increasing and relays being a significant contributor to scrams, an evaluation of control relay maintenance and replacement strategie...

2011-05-03T23:59:59.000Z

136

Early English Books on microfilm  

E-Print Network (OSTI)

search term in one box, or two if you are combining or excluding terms. You can leave the Search Three. In the next search box, enter the words early english books. Leave the other defaults alone. Now access the catalog (libcat.wichita.edu), change the default to Advanced Search: Step Two. Place your

137

High rates of adherence and treatment success in a public and public-private HIV clinic in India: potential benefits of standardized national care delivery systems  

E-Print Network (OSTI)

success in a public and public-private HIV clinic in India:Bangalore, India. Methods: Participants from public, privateand public-private HIV healthcare settings were recruited

Shet, Anita; DeCosta, Ayesha; Heylen, Elsa; Shastri, Suresh; Chandy, Sara; Ekstrand, Maria

2011-01-01T23:59:59.000Z

138

Crossover of aging dynamics in polymer glass: from cumulative aging to non-cumulative aging  

E-Print Network (OSTI)

The aging behavior of polymer glass, poly(methyl methacrylate), has been investigated through the measurement of ac dielectric susceptibility ata fixed frequency after a temperature shift $\\Delta T$ ($\\le $ 20 K)between two temperatures, $T_1$ and $T_2$. A crossover from cumulative aging to non-cumulative aging could be observed with increasing $\\Delta T$ using a twin temperature ($T$-) shift measurement. Based on a growth law of a dynamical coherent length given by activated dynamics, we obtained a unique coherent length for positive and negative $T$-shifts. The possibility of the existence of temperature chaos in polymer glasses is discussed.

Koji Fukao; Sinpei Yamawaki

2008-01-05T23:59:59.000Z

139

A Concatenational Graph Evolution Aging Model  

Science Conference Proceedings (OSTI)

Modeling the long-term face aging process is of great importance for face recognition and animation, but there is a lack of sufficient long-term face aging sequences for model learning. To address this problem, we propose a CONcatenational GRaph Evolution ... Keywords: Aging,Face,Active appearance model,Correlation,Computational modeling,Data models,Muscles,ANOVA,Face aging,aging model evaluation,long-term aging,short-term aging

Jinli Suo; Xilin Chen; Shiguang Shan; Wen Gao; Qionghai Dai

2012-11-01T23:59:59.000Z

140

Caribbean Equal Access Program: HIV/AIDS Information Resources from the National Library of Medicine  

SciTech Connect

As the treatment and management of HIV/AIDS continues to evolve with new scientific breakthroughs, treatment discoveries, and management challenges, it is difficult for people living with HIV/AIDS and those who care for them to keep up with the latest information on HIV/AIDS prevention, treatment, and research. The National Library of Medicine, of the National Institutes of Health, has a wealth of health information resources freely available on the Internet to address these needs.

Nancy Dancy, NLM, and Wilma Templin-Branner, ORISE

2009-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

NISTIR 7841 Study of Early-Age Bridge Deck Cracking in Nevada  

E-Print Network (OSTI)

]........................................................................... 6 Figure 4. Measured particle size distributions for cement, fly ash, and pigment and that computed................................................................................ 8 Figure 5. Measured chemical shrinkage for two replicate pastes prepared with cement/fly ash in these concretes. #12;5 Figure 1. Measured 28 d mean compressive strength vs. air content for Valley of Fire bridge

Bentz, Dale P.

142

Early-Age Properties of Cement-Based Materials: I. Influence ...  

Science Conference Proceedings (OSTI)

... other mitigation techniques such as the addition of slower reacting pozzolans, chilled aggregates, ice additions as part of the mixing water, and the ...

2010-06-29T23:59:59.000Z

143

The Persistence of Early Maturity: International Evidence of Long-Run Age Effects  

E-Print Network (OSTI)

role in determining minor hockey team selection for youngmore likely to have successful hockey careers. This resultsteam members acquire more hockey skills and increase their

Bedard, Kelly

2004-01-01T23:59:59.000Z

144

The Persistence of Early Maturity: International Evidence of Long-Run Age Effects  

E-Print Network (OSTI)

England Finland France Greece Iceland Italy Japan Korea Newrate countries, England, Greece, Iceland, Japan and Norway,In all countries except Greece the coefficients for boys and

Bedard, Kelly

2004-01-01T23:59:59.000Z

145

.. — AGE  

E-Print Network (OSTI)

This document is available to the public through the National Technical Information Service, Springfield, VA 22161This document is disseminated under the sponsorship of the Department of Transportation in the interest of information exchange. The United States Government assumes no liability for its contents or use thereof. * x.. 2.Gowrnmeti Aecn-io ” Mo. TPPUMICAI..... RFPOUTS. TANOARDTITIEP

V. A. Orlando; P. R. Drouilhet; Petitmins Orptiztion Mamandaddru; Proj Tqo; S-r Ag*mcv Mwoamrw

1982-01-01T23:59:59.000Z

146

The impact of Global Health Initiatives and HIV and AIDS Programs on the Zambian Health System.  

E-Print Network (OSTI)

?? Background: The Human immunodeficiency virus infection (HIV) and Acquired immunodeficiency syndrome (AIDS) epidemic peaked in 1999, which led to an increase in funding by… (more)

Lundström, Tomas

2012-01-01T23:59:59.000Z

147

HIV in Kenya: Sexual behaviour and quality of care of sexually transmitted diseases.  

E-Print Network (OSTI)

??This thesis describes three important determinants of HIV spread in Kenya: 1. Sexual behaviour of female sex workers, their clients, and young adults 2. Health… (more)

Voeten, H.A.C.M.

2006-01-01T23:59:59.000Z

148

MAPPING HIV PREVENTION IN POLAND: CONTESTED CITIZENSHIP AND THE STRUGGLES FOR HEALTH AFTER SOCIALISM.  

E-Print Network (OSTI)

??This ethnographic dissertation research project examines HIV prevention programs in Warsaw, Poland to explore the concurrent processes of democratization and privatization as Poland begins European… (more)

Owczarzak, Jill Teresa

2007-01-01T23:59:59.000Z

149

Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein  

DOE Green Energy (OSTI)

The CA domain of the human immunodeficiency virus type 1 (HIV-1) Gag polyprotein plays critical roles in both the early and late phases of viral replication and is therefore an attractive antiviral target. Compounds with antiviral activity were recently identified that bind to the N-terminal domain of CA (CA{sup N}) and inhibit capsid assembly during viral maturation. We have determined the structure of the complex between CA{sup N} and the antiviral assembly inhibitor N-(3-chloro-4-methylphenyl)-N'-{l_brace}2-[({l_brace}5-[(dimethylamino)-methyl]-2-furyl{r_brace}-methyl)-sulfanyl]ethyl{r_brace}-urea (CAP-1) using a combination of NMR spectroscopy and X-ray crystallography. The protein undergoes a remarkable conformational change upon CAP-1 binding, in which Phe32 is displaced from its buried position in the protein core to open a deep hydrophobic cavity that serves as the ligand binding site. The aromatic ring of CAP-1 inserts into the cavity, with the urea NH groups forming hydrogen bonds with the backbone oxygen of Val59 and the dimethylamonium group interacting with the side-chains of Glu28 and Glu29. Elements that could be exploited to improve binding affinity are apparent in the structure. The displacement of Phe32 by CAP-1 appears to be facilitated by a strained main-chain conformation, which suggests a potential role for a Phe32 conformational switch during normal capsid assembly.

Kelly,B.; Kyere, S.; Kinde, I.; Tang, C.; Howard, B.; Robinson, H.; Sundquist, W.; Summers, M.; Hill, C.

2007-01-01T23:59:59.000Z

150

Cost Analysis of an HIV/AIDS Prevention Project: A Case Study of the AIDS 3 Project in BENIN.  

E-Print Network (OSTI)

??HIV/AIDS Cost analysis The objective of this thesis is to undertake a cost analysis of an HIV/AIDS prevention programme targeting vulnerable groups in Benin. The… (more)

Mito-Yobo, Kodjo Ferdinand

2011-01-01T23:59:59.000Z

151

Accelerated Aging of Roofing Surfaces  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Accelerated aging of roofing surfaces Accelerated aging of roofing surfaces Hugo Destaillats, Ph.D. Lawrence Berkeley National Laboratory HDestaillats@LBL.gov (510) 486-5897 http://HeatIsland.LBL.gov April 4, 2013 Development of Advanced Building Envelope Surface Materials & Integration of Artificial Soiling and Weathering in a Commercial Weatherometer New York Times, 30 July 2009 2010 2012 Challenge: speed the development of high performance building envelope materials that resist soiling, maintain high solar reflectance, and save energy 2 | Building Technologies Office eere.energy.gov

152

Fracture, aging and disease in bone  

E-Print Network (OSTI)

and R. O. Ritchie: Effect of aging on the toughness of humanof microstructure in the aging-related deterioration of thestudy of the effect of aging on human cortical bone J.

Ager, J.W.; Balooch, G.; Ritchie, R.O.

2006-01-01T23:59:59.000Z

153

Elucidating mechanisms of accelerated neurological aging  

E-Print Network (OSTI)

C. (2005). Mechanisms of aging in senescence- accelerated2.2 Strain-specific aging gene-expression profiles…………………..C. (2005). Mechanisms of aging in senescence-accelerated

Greenhall, Jennifer Anne

2008-01-01T23:59:59.000Z

154

Telomere lengthening to antagonize myocardial aging  

E-Print Network (OSTI)

targets to antagonize the aging phenotype. FIGURES Figureday Pim-wt. Figure 2.2: Cellular aging markers over time. A.stem cell and myocyte aging, heart failure, and insulin-like

Cottage, Christopher Travis; Cottage, Christopher Travis

2012-01-01T23:59:59.000Z

155

Aging and weathering of cool roofing membranes  

E-Print Network (OSTI)

and L.S. Rose. 2002. “Aging of reflective roofs: sootAging and Weathering of Cool Roofing Membranes HashemNRC), Canada ABSTRACT Aging and weathering can reduce the

2005-01-01T23:59:59.000Z

156

Aging Logarithmic Galilean Field Theories  

E-Print Network (OSTI)

We analytically compute correlation and response functions of scalar operators for the systems with Galilean and corresponding aging symmetries for general spatial dimensions $d$ and dynamical exponent $z$, along with their logarithmic and logarithmic squared extensions, using the gauge/gravity duality. These non-conformal extensions of the aging geometry are marked by two dimensionful parameters, eigenvalue $\\mathcal M$ of an internal coordinate and aging parameter $\\alpha$. We further perform systematic investigations on two-time response functions for general $d$ and $z$, and identify the growth exponent as a function of the scaling dimensions $\\Delta$ of the dual field theory operators and aging parameter $\\alpha$ in our theory. The initial growth exponent is only controlled by $\\Delta$, while its late time behavior by $\\alpha$ as well as $\\Delta$. These behaviors are separated by a time scale order of the waiting time. We attempt to make contact our results with some field theoretical growth models, such as Kim-Kosterlitz model at higher number of spatial dimensions $d$.

Seungjoon Hyun; Jaehoon Jeong; Bom Soo Kim

2013-03-29T23:59:59.000Z

157

Mathematical Analysis of an HIV/AIDS Model: Impact of Educational Programs and Abstinence in Sub-Saharan Africa  

Science Conference Proceedings (OSTI)

We formulate a deterministic HIV/AIDS model to theoretically investigate how counselling and testing coupled with the resulting decrease in sexual activity could affect the HIV epidemic in resource-limited communities. The threshold quantities are determined ... Keywords: Abstinence, HIV/AIDS, Reproduction number, Resource-limited, Testing and counselling

C. P. Bhunu; S. Mushayabasa; H. Kojouharov; J. M. Tchuenche

2011-03-01T23:59:59.000Z

158

Aging of reflective roofs: soot deposition  

NLE Websites -- All DOE Office Websites (Extended Search)

Aging of reflective roofs: soot deposition Title Aging of reflective roofs: soot deposition Publication Type Journal Article Year of Publication 2002 Authors Berdahl, Paul, Hashem...

159

Effects of Pre-Aging Condition on Multi-Step Aging Behavior in Al ...  

Science Conference Proceedings (OSTI)

However, it is not clear the “multi-step aging” behavior such as pre-aging, natural aging and final aging. In this study, four alloys containing 0.6~1.0mass%Mg ...

160

Cumulative strategic capability and performance of early movers and followers in the cyber market  

Science Conference Proceedings (OSTI)

Today, the cyber market is evolving rapidly in the networked age. In the cyber market, the traditional competitive strategy appears to no longer be effective. This study investigates the strategic choice differences of online firms based on their strategic ... Keywords: Cyber market, Early mover, Follower, Porter's generic strategies, Sand Cone model

Sang-Gun Lee; Chulmo Koo; Kichan Nam

2010-06-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Center Late Opening or Early Closing  

Science Conference Proceedings (OSTI)

... Emergency Center Late Opening or Early Closing - Inclement Weather or Emergency Situation. ... Emergency Situation - "Shelter-in-Place" Plan. ...

2013-02-18T23:59:59.000Z

162

Effect of Mimetic CDK9 Inhibitors on HIV-1-Activated Transcription  

E-Print Network (OSTI)

University of Science and Technology, Wuhan 430074, China 6 - Protein Engineering Department, Institute transformed HIV-1 infection into a chronic manageable disease; however, drug resistance remains a common. Using these methods, we obtained the first-generation mimetic drugs and tested these compounds on HIV-1

Zeng, Chen

163

Incorporating household structure into a discrete-event simulation model of tuberculosis and HIV  

Science Conference Proceedings (OSTI)

Human immunodeficiency virus (HIV) increases the risks of developing tuberculosis (TB) disease following infection, and speeds up disease progression. This has had a devastating effect on TB epidemics in sub-Saharan Africa, where incidence rates have ... Keywords: Disease modeling, HIV, developing countries, health, simulation, tuberculosis

Georgina R. Mellor; Christine S. M. Currie; Elizabeth L. Corbett

2011-08-01T23:59:59.000Z

164

Learning long term face aging patterns from partially dense aging databases  

E-Print Network (OSTI)

Studies on face aging are handicapped by lack of long term dense aging sequences for model training. To handle this problem, we propose a new face aging model, which learns long term face aging patterns from partially dense aging databases. The learning strategy is based on two assumptions: (i) short term face aging pattern is relatively simple and is possible to be learned from currently available databases; (ii) long term face aging is a continuous and smooth Markov process. Adopting a compositional face representation, our aging algorithm learns a function-based short term aging model from real aging sequences to infer facial parameters within a short age span. Based on the predefined smoothness criteria between two overlapping short term aging patterns, we concatenate these learned short term aging patterns to build the long term aging patterns. Both the subjective assessment and objective evaluations of synthetic aging sequences validate the effectiveness of the proposed model. 1.

Jinli Suo; Xilin Chen; Shiguang Shan; Wen Gao

2009-01-01T23:59:59.000Z

165

Novel anti-HIV peptides containing multiple copies of artificially designed heptad repeat motifs  

Science Conference Proceedings (OSTI)

The peptidic anti-HIV drug T20 (Fuzeon) and its analog C34 share a common heptad repeat (HR) sequence, but they have different functional domains, i.e., pocket- and lipid-binding domains (PBD and LBD, respectively). We hypothesize that novel anti-HIV peptides may be designed by using artificial sequences containing multiple copies of HR motifs plus zero, one or two functional domains. Surprisingly, we found that the peptides containing only the non-natural HR sequences could significantly inhibit HIV-1 infection, while addition of PBD and/or LBD to the peptides resulted in significant improvement of anti-HIV-1 activity. These results suggest that these artificial HR sequences, which may serve as structural domains, could be used as templates for the design of novel antiviral peptides against HIV and other viruses with class I fusion proteins.

Shi Weiguo [Beijing Institute of Pharmacology and Toxicology, Pharmaceutical Chemistry, 27 Taiping Road, Beijing 100850 (China); Qi Zhi [Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065 (United States); Pan Chungen [Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065 (United States); College of Life Sciences, Peking University, Beijing 100871 (China); Xue Na; Debnath, Asim K. [Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065 (United States); Qie Jiankun [Beijing Institute of Pharmacology and Toxicology, Pharmaceutical Chemistry, 27 Taiping Road, Beijing 100850 (China); Jiang Shibo [Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065 (United States)], E-mail: sjiang@nybloodcenter.org; Liu Keliang [Beijing Institute of Pharmacology and Toxicology, Pharmaceutical Chemistry, 27 Taiping Road, Beijing 100850 (China)], E-mail: keliangliu@yahoo.com

2008-10-03T23:59:59.000Z

166

Closer to HIV vaccine goal with new insight into viral factors  

NLE Websites -- All DOE Office Websites (Extended Search)

Closer to HIV vaccine goal with new insight into viral factors Closer to HIV vaccine goal with new insight into viral factors New insight into viral factors that facilitate HIV transmission Understanding viral factors that facilitate transmission of HIV infection is critical to developing vaccines. February 14, 2012 Scientists work at the National Stable Isotope Resource LANL scientists found that the infected donor's predominant virus subpopulation in the genital tract differed from that in the blood. Comparing the HIV sequence population in each newly infected partner with that in the genital tract of the transmitting partner revealed that the transmitted variant was genetically distinct from the donor's predominant genital-tract variants. The results imply that a selective process, rather than a random one, determines the transmitted or founder virus.

167

Insights gained from aging research  

Science Conference Proceedings (OSTI)

The US NRC Office of Nuclear Regulatory Research has implemented hardware-oriented engineering research programs to identify and resolve technical issues related to the aging of systems, structures, and components (SSCs) in operating nuclear power plants. This report provides a summary of those research results which have been compiled and published in NUREGS and related technical reports. The systems, components and structures that have been studied are organized by alphabetical order. The research results summary on the SSCs is followed by an assessment guide to emphasize inspection techniques which may be useful for detecting aging degradation in nuclear power plants. This report will be updated periodically to reflect new research results on these or other SSCs.

Blahnik, D.E.; Casada, D.A.; Edson, J.L.; Fineman, D.L.; Gunther, W.E.; Haynes, H.D.; Hoopingarner, K.R.; Jacobus, M.J.; Jarrell, D.B.; Kryter, R.C.; Magelby, H.L.; Murphy, G.A.; Subudhi, M.M.

1992-03-01T23:59:59.000Z

168

Welding tritium aged stainless steel  

SciTech Connect

Stainless steels exposed to tritium become unweldable by conventional methods due to He buildup within the metal matrix. With longer service lives expected for new weapon systems, and service life extensions of older systems, methods for welding/repair on tritium-exposed material will become important. Results are reported that indicate that both solid-state resistance welding and low-heat gas metal arc overlay welding are promising methods for repair or modification of tritium-aged stainless steel.

Kanne, W.R. Jr.

1993-04-01T23:59:59.000Z

169

Acoustic Analysis of Adult Speaker Age  

Science Conference Proceedings (OSTI)

Information about the age of the speaker is always present in speech. It is used as perceptual cues to age by human listeners, and can be measured acoustically and used by automatic age estimators. This chapter offers an introduction to the phonetic ... Keywords: Acoustic analysis, Acoustic correlates, Phonetics, Speaker age

Susanne Schötz

2007-02-01T23:59:59.000Z

170

Metabolic reprogramming, caloric restriction and aging  

E-Print Network (OSTI)

Metabolic reprogramming, caloric restriction and aging Rozalyn M. Anderson1,2,3 and Richard) without malnutrition slows the aging process and extends lifespan in diverse species by unknown mechanisms of aging retardation. We herein describe common signatures of CR and suggest how they can slow aging. We

Sheridan, Jennifer

171

AEO2010 Early Release Overview  

Gasoline and Diesel Fuel Update (EIA)

10 10 Early Release Overview December 2009 Energy Trends to 2035 In preparing the Annual Energy Outlook 2010 (AEO- 2010), the Energy Information Administration (EIA) evaluated a wide range of trends and issues that could have major implications for U.S. energy markets. This overview focuses primarily on one case, the AEO2010 reference case, which is presented and com- pared with the updated Annual Energy Outlook 2009 (updated AEO2009) reference case released in April 2009 1 (see Table 1). Because of the uncertainties in- herent in any energy market projection, particularly in periods of high price volatility, rapid market trans- formation, or active changes in legislation, the refer- ence case results should not be viewed in isolation. Readers are encouraged to review the alternative cases when the complete AEO2010 publication is re- leased in order to gain perspective on how variations

172

Freezing Out Early Dark Energy  

E-Print Network (OSTI)

A phenomenological model of dark energy that tracks the baryonic and cold dark matter at early times but resembles a cosmological constant at late times is explored. In the transition between these two regimes, the dark energy density drops rapidly as if it were a relic species that freezes out, during which time the equation of state peaks at +1. Such an adjustment in the dark energy density, as it shifts from scaling to potential-domination, could be the signature of a trigger mechanism that helps explain the late-time cosmic acceleration. We show that the non-negligible dark energy density at early times, and the subsequent peak in the equation of state at the transition, leave an imprint on the cosmic microwave background anisotropy pattern and the rate of growth of large scale structure. The model introduces two new parameters, consisting of the present-day equation of state and the redshift of the freeze-out transition. A Monte Carlo Markov Chain analysis of a ten-dimensional parameter space is performed to compare the model with pre-Planck cosmic microwave background, large scale structure and supernova data and measurements of the Hubble constant. We find that the transition described by this model could have taken place as late as a redshift z~400. We explore the capability of future cosmic microwave background and weak lensing experiments to put tighter constraints on this model. The viability of this model may suggest new directions in dark-energy model building that address the coincidence problem.

Jannis Bielefeld; W. L. Kimmy Wu; Robert R. Caldwell; Olivier Dore

2013-05-09T23:59:59.000Z

173

Aging of Pentaerythritol Tetranitrate (PETN)  

SciTech Connect

Pentaerythritol tetranitrate (PETN) is a relatively sensitive explosive used in many electroexplosive devices as well as in medicine. Of primary interest to LLNL is its use in items such as exploding bridgewire (EBW) detonators and exploding bridge foil initiators (EFI). In these devices the crystalline powder is pressed into a granular, low-density compact that can be initiated by an exploding wire or foil. The long-term stability of this pressed compact is of interest to weapon stockpile lifetime prediction studies. Key points about potential aging mechanisms can be summarized as follows: (1) There are a number of factors that can contribute to PETN instability. These include particle size, polymorphic phase transitions, crystal structure, impurities, moisture, occlusions, chemical incompatibility and biological (microorganism) action. of these factors the most important for long-term aging of high surface area powders used in detonators appears to be that of particle size growth. (2) There is a great deal of literature on the thermal degradation kinetics of PETN, unfortunately much of it with little bearing on ambient temperature aging during long-term storage. PETN is very stable with respect to thermal decomposition. Low-temperature thermal studies have not revealed evidence of chemical degradation products in archived PETN. Data extrapolated to 30 C predicts a half-life of 12 million years. (3) Moisture seems to lower the activation energy for and accelerate the decomposition of PETN. (4) External drivers affecting stability include temperature, moisture, radiation fields, and stress, while internal drivers include residual solvents, and impurities. Temperature affects kinetic processes of crystal growth such as adsorption, desorption, and diffusion rates of molecules on the surface of PETN crystals. A low-level radiation field may induce unexpected changes in the chemical makeup of PETN and its homologue impurities. Stress at high pressure points caused by crystalline surface irregularities may cause a decrease in surface area over time due to smoothing of contact points and sintering. PETN has been found to contain a number of impurities, including homologues, pentaerythryl ethers with a mixture of hydroxyl and nitrate functional groups, and organic salts, that can alter its physical and chemical properties. (5) The processes of sublimation/recrystallization and surface diffusion are important processes that can cause changes in PETN crystal morphology, particle size distribution and specific surface area. Sublimation feeds a process called Ostwald ripening, which involves the spontaneous growth of larger crystals from those of smaller size. This process proceeds with age regardless of storage conditions unless the crystals are treated to retard growth. The coarsening mechanisms include Ostwald ripening, 'sintering', and surface diffusion. The latter has not been experimentally observed, but a molecular modeling approach has attempted to investigate this phenomenon theoretically. (6) Threshold test fire, particle size distribution, specific surface area, thermal analysis, chemical analysis, powder compact specific surface area and density are approaches that have been used in the attempt to assess changes attributable to aging of PETN, with varying results. The biggest problem lies in the aging mechanism itself, which likely influences small changes in morphology, both internal and external, and particle size distribution changes on a scale too small to reliably monitor. Other aspects, such as subtle changes in density profiles within pressed powder compacts, may be beyond the capability of current technology to assess. Crystal growth significant enough to affect the PETN particle size distribution is expected to impact detonator performance. (7) Factors relevant to stabilizing particle size growth include crystal morphology, powder surface area and particle size distribution; crystal density and internal defects; and powder compact density and density gradients.

Foltz, M F

2009-04-22T23:59:59.000Z

174

SNF AGING SYSTEM DESCRIPTION DOCUMENT  

Science Conference Proceedings (OSTI)

The purpose of this system description document (SDD) is to establish requirements that drive the design of the spent nuclear fuel (SNF) aging system and associated bases, which will allow the design effort to proceed. This SDD will be revised at strategic points as the design matures. This SDD identifies the requirements and describes the system design, as it currently exists, with emphasis on attributes of the design provided to meet the requirements. This SDD is an engineering tool for design control; accordingly, the primary audience and users are design engineers. This SDD is part of an iterative design process. It leads the design process with regard to the flow down of upper tier requirements onto the system. Knowledge of these requirements is essential in performing the design process. The SDD follows the design with regard to the description of the system. The description provided in the SDD reflects the current results of the design process. Throughout this SDD, the term aging cask applies to vertical site-specific casks and to horizontal aging modules. The term overpack is a vertical site-specific cask that contains a dual-purpose canister (DPC) or a disposable canister. Functional and operational requirements applicable to this system were obtained from ''Project Functional and Operational Requirements'' (F&OR) (Curry 2004 [DIRS 170557]). Other requirements that support the design process were taken from documents such as ''Project Design Criteria Document'' (PDC) (BSC 2004 [DES 171599]), ''Site Fire Hazards Analyses'' (BSC 2005 [DIRS 172174]), and ''Nuclear Safety Design Bases for License Application'' (BSC 2005 [DIRS 171512]). The documents address requirements in the ''Project Requirements Document'' (PRD) (Canori and Leitner 2003 [DIRS 166275]). This SDD includes several appendices. Appendix A is a Glossary; Appendix B is a list of key system charts, diagrams, drawings, lists and additional supporting information; and Appendix C is a list of procedures that will be used to operate the system.

L.L. Swanson

2005-04-06T23:59:59.000Z

175

Equal Access Initiative HIV/AIDS Information Resources from NLM  

SciTech Connect

The Equal Access Initiative: HIV/AIDS Information Resources from the National Library of Medicine training is designed specifically for the National Minority AIDS Council 2010 Equal Access Initiative (EAI) Computer Grants Program awardees to provide valuable health information resources from the National Library of Medicine and other reliable sources to increase awareness of the wealth of treatment information and educational materials that are available on the Internet and to improve prevention and treatment education for their clients. These resources will also meet the needs of community-based

Templin-Branner W. and N. Dancy

2010-09-11T23:59:59.000Z

176

Mathematical link of evolving aging and complexity  

E-Print Network (OSTI)

Aging is a fundamental aspect of living systems that undergo a progressive deterioration of physiological function with age and an increase of vulnerability to disease and death. Living systems, known as complex systems, require complexity in interactions among molecules, cells, organs, and individuals or regulatory mechanisms to perform a variety of activities for survival. On this basis, aging can be understood in terms of a progressive loss of complexity with age; this suggests that complexity in living systems would evolve with age. In general, aging dynamics is mathematically depicted by a survival function, which monotonically changes from 1 to 0 with age. It would be then useful to find an adequate survival function to link aging dynamics and complexity evolution. Here we describe a flexible survival function, which is derived from the stretched exponential function by adopting an age-dependent exponent. We note that the exponent is associated with evolving complexity, i.e., a fractal-like scaling in c...

Weon, Byung Mook

2010-01-01T23:59:59.000Z

177

Neural Effects of Beta Amyloid in Normal Aging  

E-Print Network (OSTI)

age   categories.  Neurobiol  Aging  1997;  18:  351-­?7.  JK,  McIntosh  AR.  Aging  gracefully:  compensatory  B.  The  effect  of  normal  aging  on  the  coupling  of  

Mormino, Elizabeth Charlotte

2011-01-01T23:59:59.000Z

178

Aging discrepancies of white spruce affect the interpretation of static age structure in boreal  

E-Print Network (OSTI)

NOTE Aging discrepancies of white spruce affect the interpretation of static age structure. Our objectives were to determine whether ground-level ring counts underestimate root collar age of understory P. glauca and whether aging errors increase with stand age. Trees were collected from one to nine

Macdonald, Ellen

179

EIA - Annual Energy Outlook 2014 Early Release  

U.S. Energy Information Administration (EIA) Indexed Site

AEO2014 Early Release Overview AEO2014 Early Release Overview Release Date: December 16, 2013 | Full Report Release Date: Early Spring 2014 | correction | Report Number: DOE/EIA-0383ER(2014) This release is an abridged version of the Annual Energy Outlook that highlights changes in the AEO Reference case projections for key energy topics. The Early Release includes data tables for the Reference case only. The AEO2014 full version will be released early Spring 2014. Download the AEO2014 Early Release Report Introduction In preparing the AEO2014 Reference case, the U.S. Energy Information Administration (EIA) evaluated a wide range of trends and issues that could have major implications for U.S. energy markets. This overview presents the AEO2014 Reference case and compares it with the AEO2013 Reference case

180

Aging phenomena in polystyrene thin films  

E-Print Network (OSTI)

The aging behavior is investigated for thin films of atactic polystyrene through measurements of complex electric capacitance. During isothermal aging process the real part of the electric capacitance increases with aging time, while the imaginary part decreases with aging time. This result suggests that the aging time dependence of the real and imaginary parts are mainly associated with change in thickness and dielectric permittivity, respectively. In thin films, the thickness depends on thermal history of aging even above the glass transition. Memory and `rejuvenation' effects are also observed in the thin films.

Koji Fukao; Hiroki Koizumi

2008-01-05T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

EETD's Early Technological Successes-Data Centers  

NLE Websites -- All DOE Office Websites (Extended Search)

EETD's Early Technological Successes-Data Centers EETD's successes: data center energy efficiency November 2013 The 40th anniversary of the founding of the Environmental Energy...

182

Early Science Program Investigators Meeting | Argonne Leadership...  

NLE Websites -- All DOE Office Websites (Extended Search)

through ambitious scientific computations enabled by the ALCF's Early Science Program (ESP). Investigators from each of the 16 ESP projects will overview their simulation...

183

Scaling up prevention of mother-to-child HIV transmission programs in sub-Saharan African countries: a multilevel assessment of site-, program- and country-level determinants of performance  

E-Print Network (OSTI)

of mother- to-child HIV transmission programs in sub-Saharanof mother-to-child transmission of HIV following effectiveof mother-to-child HIV transmission in the UK and Ireland,

Audureau, Etienne; Kahn, James G; Besson, Marie-Hélčne; Saba, Joseph; Ladner, Joël

2013-01-01T23:59:59.000Z

184

(COPVs) Materials Aging Issues - Programmaster.org  

Science Conference Proceedings (OSTI)

Three aspects of COPV aging were considered; the age life of the Kevlar overwrap, the fatigue life of the titanium liner and the stress rupture life of the combined ...

185

CREEP BEHAVIOR AND PHYSICAL AGING INFLUENCE IN ...  

Science Conference Proceedings (OSTI)

CREEP BEHAVIOR AND PHYSICAL AGING INFLUENCE IN PEN FILM. ML Cerrada, GB McKenna. Structure and Mechanics ...

186

PHYSICAL AGING OF PLASTICIZED POLYMER GLASS. WH ...  

Science Conference Proceedings (OSTI)

PHYSICAL AGING OF PLASTICIZED POLYMER GLASS. WH Han and GB McKenna, Polymers Division, Building 224, Room ...

187

Health Studies: Aging Services Bachelor of Science  

E-Print Network (OSTI)

Health Studies: Aging Services Bachelor of Science 201213 Degree Map First Year Fall Winter,2 4 PHE 456 4 PHE 410 Business of Aging 4 PHE 454 4 PHE 443 4 SOC 469 or PSY 462 4 PHE PHE 450 4 BA 306, BA 316, or BA 326 4 Senior Capstone 6 SP 447 or PHE 410 Families & Aging

Bertini, Robert L.

188

HYGROTHERMAL AGING OF POLYIMIDE MATRIX COMPOSITE LAMINATES  

E-Print Network (OSTI)

HYGROTHERMAL AGING OF POLYIMIDE MATRIX COMPOSITE LAMINATES John A. Nairn and Man-Hee Han Materials-0560, USA SUMMARY: Two polyimide-matrix systems were subjected to a series of hygrothermal aging experiments at various temperatures and relative humidities. For each aging condition, we measured the microcracking

Nairn, John A.

189

Careers in Aging Annual Southeastern Student  

E-Print Network (OSTI)

1 Careers in Aging The 23rd Annual Southeastern Student Mentoring Conference in Gerontology and Geriatrics Keynote Addresses and Poster Abstracts Edited by Christina Barmon #12;2 Careers in Aging The 23rd. This year's conference theme, "Careers in Aging," attracted one of the largest most diverse groups

Arnold, Jonathan

190

Health Studies: Aging Services Bachelor of Arts  

E-Print Network (OSTI)

Health Studies: Aging Services Bachelor of Arts 201213 Degree Map First Year Fall Winter PHE 410 Business of Aging 4 PHE 454 4 PHE 456 4 PHE 425 4 PHE 443 4 PHE Approved Elective Capstone 6 SOC 469 or PSY 462 4 SP 447 or PHE 410 Families & Aging 4 PHE Approved Elective 4 PHE

Bertini, Robert L.

191

Statistical aging analysis with process variation consideration  

Science Conference Proceedings (OSTI)

As CMOS devices become smaller, process and aging variations become a major issue for circuit reliability and yield. In this paper, we analyze the effects of process variations on aging effects such as hot carrier injection (HCI) and negative bias temperature ... Keywords: HCI, NBTI, aging variation, process variation, reliability

Sangwoo Han; Joohee Choung; Byung-Su Kim; Bong Hyun Lee; Hungbok Choi; Juho Kim

2011-11-01T23:59:59.000Z

192

Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage  

E-Print Network (OSTI)

, transduction of neural stem cells with lentiviral and adeno associated viral vectors express- ing therapeutic genes that will affect differentiation and Gag-Pol packaging constructsFigure 1 Gag-Pol packaging constructs. gag Poly ApolLTR vpx vprvif rev tat ?Env... (1153bp) ?? ? ? gag Poly A polCMV rev tat ?Env ?? HIV-1 Gag-Pol ?8.9 (2nd Generation) gag LTRpolLTR vpx vprvif rev tat nef ?Env (550bp) ?? ? ? RRE RRE RRE SIV Gag-Pol (SgpDelta2) Gag-Pol packaging constructs HIV-2 Gag-PolPage 2 of 14 (page number...

Strappe, Padraig M; Hampton, David W; Brown, Douglas; Gonzales, Begona-cachon; Caldwell, Maeve; Fawcett, James W; Lever, Andrew M L

2005-09-16T23:59:59.000Z

193

HIV prevalence and awareness among wives of rural migrant workers of Muzaffarpur district in Bihar, India  

E-Print Network (OSTI)

Books; 1955. 51. Kumari R. Rural female adolescence: Indiansex work and HIV/AIDS in rural India. Soc Sci Med 6. Boerma2 infection in urban and rural areas in Tamil Nadu, India.

Ranjan, Alok

2013-01-01T23:59:59.000Z

194

Using Cellular Automata to Model the Spread of HIV among ... - CECM  

E-Print Network (OSTI)

If we increase the value of h, the graph will cycle fewer times. ... When we run this model, the rate of HIV infection is so high that the entire population becomes.

195

HIV/AIDS risk behaviors and correlates of injection drug use among drug users in Pakistan.  

E-Print Network (OSTI)

transfusion risks in Karachi, Pakistan. Int J Infect Dis.dis- orders in Pakistan. AIDS Res Hum Retroviruses. 1988;4:threat: HIV/AIDS policy in Pakistan. Health Policy Plann.

2003-01-01T23:59:59.000Z

196

Optimization of HAART with genetic algorithms and agent-based models of HIV infection  

Science Conference Proceedings (OSTI)

Motivation: Highly Active AntiRetroviral Therapies (HAART) can prolong life significantly to people infected by HIV since, although unable to eradicate the virus, they are quite effective in maintaining control of the infection. However, since ...

F. Castiglione; F. Pappalardo; M. Bernaschi; S. Motta

2007-12-01T23:59:59.000Z

197

Aging Services Program Grants Specialist Division of Aging Services, Livable Communities Section  

E-Print Network (OSTI)

Aging Services Program Grants Specialist Division of Aging Services, Livable Communities Section Job Description The Georgia Department of Human Services (DHS), Division of Aging Services, is seeking qualified candidates for the position of Aging Services Program Grants Specialist for the Livable

Arnold, Jonathan

198

Aging Services Program Administrator Division of Aging Services, Livable Communities Section  

E-Print Network (OSTI)

Aging Services Program Administrator Division of Aging Services, Livable Communities Section Job Description The Georgia Department of Human Services (DHS), Division of Aging Services, (DAS)is seeking qualified candidates for the position of Aging Services Program Administrator for the Livable Communities

Arnold, Jonathan

199

AGING PERFORMANCE OF MODEL 9975 PACKAGE FLUOROELASTOMER O-RINGS  

Science Conference Proceedings (OSTI)

The influence of temperature and radiation on Viton{reg_sign} GLT and GLT-S fluoroelastomer O-rings is an ongoing research focus at the Savannah River National Laboratory. The O-rings are credited for leaktight containment in the Model 9975 shipping package used for transportation of plutonium-bearing materials. At the Savannah River Site, the Model 9975 packages are being used for interim storage. Primary research efforts have focused on surveillance of O-rings from actual packages, leak testing of seals at bounding aging conditions and the effect of aging temperature on compression stress relaxation behavior, with the goal of service life prediction for long-term storage conditions. Recently, an additional effort to evaluate the effect of aging temperature on the oxidation of the materials has begun. Degradation in the mechanical properties of elastomers is directly related to the oxidation of the polymer. Sensitive measurements of the oxidation rate can be performed in a more timely manner than waiting for a measurable change in mechanical properties, especially at service temperatures. Measuring the oxidation rate therefore provides a means to validate the assumption that the degradation mechanisms(s) do not change from the elevated temperatures used for accelerated aging and the lower service temperatures. Monitoring the amount of oxygen uptake by the material over time at various temperatures can provide increased confidence in lifetime predictions. Preliminary oxygen consumption analysis of a Viton GLT-based fluoroelastomer compound (Parker V0835-75) using an Oxzilla II differential oxygen analyzer in the temperature range of 40-120 C was performed. Early data suggests oxygen consumption rates may level off within the first 100,000 hours (10-12 years) at 40 C and that sharp changes in the degradation mechanism (stress-relaxation) are not expected over the temperature range examined. This is consistent with the known long-term heat aging resistance of fluoroelastomers relative to hydrocarbon-based elastomers, and in absence of antioxidants that may be consumed over time. Additional experimental effort will be undertaken in the short term range within the first 100 hours of thermal aging to capture further details of the oxygen consumption rate.

Hoffman, E.; Daugherty, W.; Skidmore, E.; Dunn, K.; Fisher, D.

2011-05-31T23:59:59.000Z

200

The relationship of self transcendance, social interest, and spirituality to well-being in HIV-AIDS adults.  

E-Print Network (OSTI)

??This study investigates the relationship of three protective factors : self transcendance, social interest, and spirituality to well-being among adults living with HIV or AIDS.… (more)

Sperry, Jonathan J.

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Life beyond infection : home-based pastoral care to people with HIV-positive status within a context of poverty.  

E-Print Network (OSTI)

??The basic premise of this study is that the congregation is the key to providing homebased pastoral care support to HIV-positive people in poor contexts.… (more)

Magezi, Vhumani

2005-01-01T23:59:59.000Z

202

The role of individual or neighborhood factors: HIV acquisition risk among high-risk populations in San Francisco  

E-Print Network (OSTI)

distribution of study participants Residence Zip (n)Neighborhood ZIP BMT White MSM Teach General Delivery HayesUse ZipHP – residential zip code HIV prevalence, increasing

Raymond, Henry Fisher

2011-01-01T23:59:59.000Z

203

Rock of Ages | Open Energy Information  

Open Energy Info (EERE)

of Ages of Ages Jump to: navigation, search Name Rock of Ages Facility Rock of Ages Sector Wind energy Facility Type Small Scale Wind Facility Status In Service Owner Rock of Ages Energy Purchaser Rock of Ages Location Graniteville VT Coordinates 44.14668574°, -72.48180896° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":44.14668574,"lon":-72.48180896,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

204

Modeling the transmission of HIV in the Texas State Prison population  

E-Print Network (OSTI)

An infectious disease that is widespread globally is acquired immune deficiency syndrome (AIDS). AIDS is spread by the human immunodeficiency virus (HIV). The purpose of this study was to develop a simulation model to study the transmission of HIV via intravenous drug use in a Texas State prison population. By developing a model to track the movement of HIV in the prison, public health authorities could suggest policies to better serve those HIV positive prisoners released into the general population. Also, this model provided a means to quantitatively study the effect of intervention strategies against the virus (increase or reduction of infection rate). The minimum-security prison of Huntsville, Texas, was chosen as the site for the simulation study. Parameter values were estimated from data in existing literature. Vital statistics such as the mean number of prisoners without HIV, with HIV, and those with AIDS were collected and analyzed at the end of 10 years. Simulation schemes were structured on an event driven basis, the existence of syringes in prison by smuggling, or no syringes in prison. A parametric analysis was conducted by changing three of the parameters one at a time: the probability of syringe smuggling, the probability of a newly admitted prisoner to be HIV positive, and the mean number of injections per day Results from the base run showed that there were more than 3 infections per syringe-existing day, or about 0.2% of the prison population. Successful syringe smuggling translated into HIV transmission of anywhere from 3 to more than 20 new infectives per virus spreading event period. These numbers are alarming, as this would reach epidemic proportions. Results from the parametric analysis showed that most of the HIV positives released were a result of syringe sharing and most of the prisoners who developed AIDS were from prisoners admitted into prison with HIV. The structure and procedure of this simulation model can be employed to study other epidemics that may threaten public health. By using our simulation model as a basis, models could be developed to study other infectious diseases and in different types of environments.

Tay, Edward Chor-Ying

2000-01-01T23:59:59.000Z

205

Five-year Distribution and Patterns of Maternal Child Health Indicators after Institution of PEPFAR and Global HIV/AIDS Initiatives in Uganda.  

E-Print Network (OSTI)

??As the HIV/AIDS epidemic escalated worldwide, the global community responded by a large increase in international aid to countries with high HIV/AIDS prevalence such as… (more)

Nguyen, Jeannie

2013-01-01T23:59:59.000Z

206

THE EARLY ANTIPROTON WORK [Nobel Lecture  

SciTech Connect

Early work on the antiproton, particularly that part which led to the first paper on the subject, is described. Conclusions that can be drawn purely from the existence of the antiproton are discussed. (W.D.M.)

Chamberlain, O.

1959-12-15T23:59:59.000Z

207

EIA - Annual Energy Outlook 2013 Early Release  

Gasoline and Diesel Fuel Update (EIA)

AEO2013 Early Release Overview AEO2013 Early Release Overview Release Date: December 5, 2012 | Report Release Schedule: April 15 - May 2, 2013 | Report Number: DOE/EIA-0383ER(2013) This release is an abridged version of the Annual Energy Outlook that highlights changes in the AEO Reference case projections for key energy topics. The Early Release includes data tables for the Reference case only. The AEO2013 will be released between April 15 and May 2. See release schedule. . Download the AEO2013 Early Release Report Introduction In preparing the AEO2013 Reference case, the U.S. Energy Information Administration (EIA) evaluated a wide range of trends and issues that could have major implications for U.S. energy markets. This overview presents the AEO2013 Reference case and compares it with the AEO2012 Reference case

208

Haptic holography : an early computational plastic  

E-Print Network (OSTI)

This dissertation introduces haptic holography, a combination of computational modeling and multimodal spatial display, as an early computationalplastic In this work, we combine various holographic displays with a force ...

Plesniak, Wendy J. (Wendy Jean)

2001-01-01T23:59:59.000Z

209

A technique for early software reliability prediction  

Science Conference Proceedings (OSTI)

In early developmental stages of software, failure data is not available to determine the reliability of software. But developers need reliability prediction for quality assessment and resource planning. We propose a model based on Reliability Block ...

Rakesh Tripathi; Rajib Mall

2005-12-01T23:59:59.000Z

210

Isocurvature Fluctuations Induce Early Star Formation  

E-Print Network (OSTI)

The early reionisation of the Universe inferred from the WMAP polarisation results, if confirmed, poses a problem for the hypothesis that scale-invariant adiabatic density fluctuations account for large-scale structure and galaxy formation. One can only generate the required amount of early star formation if extreme assumptions are made about the efficiency and nature of early reionisation. We develop an alternative hypothesis that invokes an additional component of a non-scale-free isocurvature power spectrum together with the scale-free adiabatic power spectrum for inflation-motivated primordial density fluctuations. Such a component is constrained by the Lyman alpha forest observations, can account for the small-scale power required by spectroscopic gravitational lensing, and yields a source of early star formation that can reionise the universe at z~20 yet becomes an inefficient source of ionizing photons by z~10, thereby allowing the conventional adiabatic fluctuation component to reproduce the late thermal history of the intergalactic medium.

Naoshi Sugiyama; Saleem Zaroubi; Joseph Silk

2003-10-21T23:59:59.000Z

211

Aging and weathering of cool roofing membranes  

E-Print Network (OSTI)

National Research Council (NRC), Canada ABSTRACT Aging andNational Research Council (NRC) in Canada. The LBNL studyits original levels. The NRC study also included measuring

2005-01-01T23:59:59.000Z

212

Materials Research in the Information Age  

NLE Websites -- All DOE Office Websites (Extended Search)

Research in the Information Age Accelerating Advanced Material Development NERSC Science Gateway a 'Google of Material Properties' October 31, 2011 | Tags: Materials Science,...

213

Understanding Aging: A Medical Humanities Approach to “Death in Venice“  

E-Print Network (OSTI)

issues, understanding aging from a humanistic perspective isattempting to understand aging, I have divided the text intoAschenbach's experience with aging while in Germany. This

English, David

2008-01-01T23:59:59.000Z

214

Departure and return : abandonment, memorial and aging in Japan  

E-Print Network (OSTI)

S. Linhart (Eds. ), Aging Asian Concepts and ExperiencesJ. J. Seeber (Eds. ), .Aging, Spirituality and Religion: AE. (1964). The Psychology of Aging. Englewood Cliffs, N.J. :

Danely, Jason Allen

2008-01-01T23:59:59.000Z

215

The thorny path linking cellular senescence to organismal aging  

E-Print Network (OSTI)

tumor suppression and organismal aging: Good citizens, badtelomere-directed replicative aging in vitro. Mech. Ageinglung fibroblasts by telomerase. Aging Cell 2, Hayflick, L. ,

Patil, Christopher K.; Mian, Saira; Campisi, Judith

2005-01-01T23:59:59.000Z

216

DNA repair: Dynamic defenders against cancer and aging  

E-Print Network (OSTI)

developmental defects; premature aging; brittle hair; scalypredisposition and premature aging. Acknowledgements. Weagainst cancer and aging Jill O. Fuss and Priscilla K.

Fuss, Jill O.; Cooper, Priscilla K.

2006-01-01T23:59:59.000Z

217

Incorporating safety risk in early system architecture trade studies  

E-Print Network (OSTI)

Ideally, safety should be a part of the early decision making used in conceptual system design. However, effectively evaluating safety risk3 early enough to inform the early trade studies is not possible with current ...

Dulac, Nicholas

218

Those early days as we remember them (Part VII) - Met Lab & Early Argonne History  

NLE Websites -- All DOE Office Websites (Extended Search)

VII | Met Lab and Early Argonne History | Argonne National Laboratory VII | Met Lab and Early Argonne History | Argonne National Laboratory 1/7 Those early days as we remember them Part VlI Norman Hilberry, director of Argonne National Laboratory (seated) and Dean E. Dalquest (standing), superintendent of the laboratory's Graphic Arts division. They are examining an historic galvanometer recording of the fluctuation in a neutron density in Chicago Pile No.

219

Those early days as we remember them (Part V) - Met Lab & Early Argonne History  

NLE Websites -- All DOE Office Websites (Extended Search)

V | Met Lab and Early Argonne History | Argonne National Laboratory V | Met Lab and Early Argonne History | Argonne National Laboratory 1/3 Those early days as we remember them Part V Farrington Daniels Professor Emeritus of Chemistry The University of Wisconsin Editor's note: Dr. Farrington Daniels was Director of the Metallurgical Laboratory when it became Argonne National Laboratory on July 1, 1946. At that time he returned to his chemistry professorship at the University of

220

Failure diagnosis of asymmetric aging under NBTI  

Science Conference Proceedings (OSTI)

Design for reliability is becoming an important step in the design cycle with CMOS technology scaling, demanding need for efficient and accurate reliability simulation methods in the design stage. Traditional aging analysis does not differentiate NBTI ... Keywords: asymmetric aging, design for reliability, negative bias temperature instability, static timing analysis

Jyothi Bhaskarr Velamala; Venkatesa Ravi; Yu Cao

2011-11-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

The participatory potential of early cinema: a reexamination of early projected films.  

E-Print Network (OSTI)

??This paper examines the formal qualities and historic context of three early films produced for the Edison Manufacturing Company by James White and Frederick Blechynden… (more)

Daniel, Jessica A.

2010-01-01T23:59:59.000Z

222

Transcriptional profiling of aging in human muscle reveals a common aging signature  

E-Print Network (OSTI)

We analyzed expression of 81 normal muscle samples from humans of varying ages, and have identified a molecular profile for aging consisting of 250 age-regulated genes. This molecular profile correlates not only with chronological age but also with a measure of physiological age. We compared the transcriptional profile of muscle aging to previous transcriptional profiles of aging in the kidney and the brain, and found a common signature for aging in these diverse human tissues. The common aging signature consists of six genetic pathways; four pathways increase expression with age (genes in the extracellular matrix, genes involved in cell growth, genes encoding factors involved in complement activation, and genes encoding components of the cytosolic ribosome), while two pathways decrease expression with age (genes involved in chloride transport and genes encoding subunits of the mitochondrial electron transport chain). We also compared transcriptional profiles of aging in humans to those of the mouse and fly, and found that the electron transport chain pathway decreases expression with age in all three organisms, suggesting that this may be a

Jacob M. Zahn; Rebecca Sonu; Hannes Vogel; Emily Crane; Krystyna Mazan-mamczarz; Ralph Rabkin; Ronald W. Davis; Kevin G. Becker; Art B. Owen; Stuart K. Kim

2006-01-01T23:59:59.000Z

223

Long-Term Surveillance and Maintenance at Rocky Flats: Early...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

at Rocky Flats: Early Experiences and Lessons Learned Long-Term Surveillance and Maintenance at Rocky Flats: Early Experiences and Lessons Learned Long-Term Surveillance and...

224

Green Power Marketing in Retail Competition: An Early Assessment  

NLE Websites -- All DOE Office Websites (Extended Search)

Green Power Marketing in Retail Competition: An Early Assessment Title Green Power Marketing in Retail Competition: An Early Assessment Publication Type Report Year of Publication...

225

Early Stage R&D Available for Partnerships - Energy Innovation ...  

Bookmark Early Stage R&D Available for Partnerships - Energy Innovation Portal on Google; Bookmark Early Stage R&D Available for Partnerships ...

226

DOE's Early Investment in Shale Gas Technology Producing Results...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DOE's Early Investment in Shale Gas Technology Producing Results Today DOE's Early Investment in Shale Gas Technology Producing Results Today February 2, 2011 - 12:00pm Addthis...

227

Late Paleozoic-early Mesozoic history of the Pacific margin along Antarctica  

SciTech Connect

The late Paleozoic-early Mesozoic Pacific margin of Gondwanaland from eastern Australia to Patagonia was characterized by a series of back-arc and foreland basins associated with subduction and volcanism. The Transantarctic basin including the present Transantarctic Mountains and Tasmania evolved from a middle Paleozoic passive continental margin to an Early Permian back-arc basin and a Late Permian-Triassic foreland basin. The earliest evidence of a volcanic arc and subduction is the appearance of abundant volcanic detritus at the base of the Early Permian postglacial marine shale-and-sandstone sequence in the Ellsworth Mountains. Volcaniclastic forearc sediments of Permian( ) to Triassic age are known from the Antarctic Peninsula. The introduction of abundant volcanic detritus to the East Antarctic craton and a 180{degree} paleocurrent reversal in the Late Permian in the Beardmore Glacier area is the earliest evidence of folding along the Antarctic-Pacific margin. By the Early Triassic, folding involved Late Permian sequences in the Ellsworth and Transantarctic (Pensacola) mountains. Thick Upper Permian and Triassic braided-stream deposits of mixed volcanic and cratonic provenance accumulated in this foreland basin. Subsidence ended in the Early Jurassic with uplift and diabase intrusion associated with the breakup of Gondwanaland.

Collinson, J.W.; Isbell, J.L. (Ohio State Univ., Columbus (USA)); Miller, M.F. (Vanderbilt Univ., Nashville, TN (USA))

1990-05-01T23:59:59.000Z

228

The Passenger Steamboat Phoenix: An Archaeological Study of Early Steam Propulsion in North America  

E-Print Network (OSTI)

The advent of steam contributed heavily to the economic transformation of early America, facilitating trade through the transportation of goods along the country’s lakes, rivers, and canals. Serious experimentation with steam navigation began in the last quarter of the 18th century. By the turn of the 19th century, fledgling US steamboat companies vied for control of navigation rights in the country’s northern waterways. The second steamboat to be launched on Lake Champlain, Phoenix, operated as a passenger steamer between 1815 and 1819, when she caught fire and sank in the lake. The intention of this study is to advance our knowledge of early steamboat design and use in the United States through the archaeological investigation of the country’s earliest-known steamboat wreck. As little is known about the development of these early steam vessels, the study of Phoenix offers a unique opportunity to gain new information related to steamboat design in the early 19th century as well as a glimpse into life on the lakes and rivers of North America during this era. The dissertation presents detailed information on Phoenix’s construction, operation, and sinking based on historical and archaeological analysis and interpretation. In combination with the available archival record and analytical comparisons with steamboats of similar size and age, a more comprehensive understanding of the developmental phases of steam travel and its impact on early America can be gained.

Schwarz, George 1977-

2012-12-01T23:59:59.000Z

229

Effect of Composition and Pre-ageing on the Natural Ageing and ...  

Science Conference Proceedings (OSTI)

Presentation Title, Effect of Composition and Pre-ageing on the Natural Ageing ..... Powder Metallurgy of High Strength Al84Gd6Ni7Co3 Gas-atomized Powder.

230

Expanded breadth of the T-cell response to mosaic HIV-1 envelope DNA vaccination  

SciTech Connect

An effective AIDS vaccine must control highly diverse circulating strains of HIV-1. Among HIV -I gene products, the envelope (Env) protein contains variable as well as conserved regions. In this report, an informatic approach to the design of T-cell vaccines directed to HIV -I Env M group global sequences was tested. Synthetic Env antigens were designed to express mosaics that maximize the inclusion of common potential Tcell epitope (PTE) 9-mers and minimize the inclusion of rare epitopes likely to elicit strain-specific responses. DNA vaccines were evaluated using intracellular cytokine staining (ICS) in inbred mice with a standardized panel of highly conserved 15-mer PTE peptides. I, 2 and 3 mosaic sets were developed that increased theoretical epitope coverage. The breadth and magnitude ofT-cell immunity stimulated by these vaccines were compared to natural strain Env's; additional comparisons were performed on mutant Env's, including gpl60 or gpl45 with or without V regions and gp41 deletions. Among them, the 2 or 3 mosaic Env sets elicited the optimal CD4 and CD8 responses. These responses were most evident in CD8 T cells; the 3 mosaic set elicited responses to an average of 8 peptide pools compared to 2 pools for a set of3 natural Env's. Synthetic mosaic HIV -I antigens can therefore induce T-cell responses with expanded breadth and may facilitate the development of effective T -cell-based HIV -1 vaccines.

Korber, Bette [Los Alamos National Laboratory; Fischer, William [Los Alamos National Laboratory; Wallstrom, Timothy [Los Alamos National Laboratory

2009-01-01T23:59:59.000Z

231

Falls, Disability and Food Insecurity Present Challenges to Healthy Aging  

E-Print Network (OSTI)

characteristics. Journal of Aging Health. 2001. 13:329-54.for prevention. Age and Aging. 2006:35 Supplement 2:ii37-Present Challenges to Healthy Aging Steven P. Wallace, L.

Wallace, Steven P.; Molina, L. Cricel; Jhawar, Mona

2007-01-01T23:59:59.000Z

232

TWO SENSOR SYSTEM FOR A SOLUTE AGE AND TEMPERATURE HISTORY  

the aging period Can determine absolute age independently of temperature history Suitable for emplacement on circuit boards Numerous commercial ...

233

Early Detection Saves Lives | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Early Detection Saves Lives Early Detection Saves Lives Early Detection Saves Lives September 20, 2012 - 2:39pm Addthis What does this mean for me? It can save your life. It can save the life of someone you love. The Worker Health Protection Program (WHPP) is the DOE's Former Worker Medical Screening Program at 13 DOE sites. WHPP provides free medical evaluations for selected occupational diseases every three years to eligible former DOE workers under a national medical protocol established by the DOE. WHPP is funded by the DOE and is operated by a consortium of the City University of New York, the United Steelworkers, and the Atomic Trades & Labor Council in association with clinical facilities in communities near DOE sites. The sites covered under WHPP include the K-25 Gaseous Diffusion Plant, Y-12 National Security Complex, Oak Ridge National

234

LANL exceeds Early Recovery Act recycling goals  

NLE Websites -- All DOE Office Websites (Extended Search)

LANL exceeds Early Recovery Act recycling goals LANL exceeds Early Recovery Act recycling goals LANL exceeds Early Recovery Act recycling goals Lab demolition projects under the American Recovery and Reinvestment Act have recovered more than 136 tons of recyclable metal since work began last year. March 8, 2010 Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials. Los Alamos National Laboratory sits on top of a once-remote mesa in northern New Mexico with the Jemez mountains as a backdrop to research and innovation covering multi-disciplines from bioscience, sustainable energy sources, to plasma physics and new materials.

235

New Constraints on the Early Expansion History  

E-Print Network (OSTI)

Cosmic microwave background measurements have pushed to higher resolution, lower noise, and more sky coverage. These data enable a unique test of the early universe's expansion rate and constituents such as effective number of relativistic degrees of freedom and dark energy. Using the most recent data from Planck and WMAP9, we constrain the expansion history in a model independent manner from today back to redshift z=10^5. The Hubble parameter is mapped to a few percent precision, limiting early dark energy and extra relativistic degrees of freedom within a model independent approach to 2-16% and 0.71 equivalent neutrino species respectively (95% CL). Within dark radiation, barotropic aether, and Doran-Robbers models, the early dark energy constraints are 3.3%, 1.9%, 1.2% respectively.

Hojjati, Alireza; Samsing, Johan

2013-01-01T23:59:59.000Z

236

Warmly Debated: The Little Ice Age and the Construction of Historical Climatic Regimes, 1650-1950  

E-Print Network (OSTI)

Climatic change has been the subject of investigation and spirited debate for more than three centuries. One important element of this debate has been the search for and definition of unique, impermanent climatic regimes measurable by historic time. The Medieval Warm Period and the Little Ice Age are the two most commonly referenced and discussed of such regimes. This thesis examines the theories and debates that preceded and surrounded the formal definition of the Little Ice Age as an historic period of approximately 1550-1850 AD. This thesis begins by describing early attempts to measure and record climatic conditions during the late seventeenth and early eighteenth centuries while also demonstrating that climatic change and climatic influence were matters of concern for both the scientific and philosophical elite and the public. By the first decade of the nineteenth century, however, discussion of climatic change had begun to center on comparisons of the medieval past and the cooler present. Climatic change itself often intruded on debates about past climates during the early nineteenth century. By 1900, however, both scholars and laymen had begun to recognize that some form of climatic change had occurred in the sixteenth century. Early twentieth century scholars such as Otto Pettersson, Charles Rabot, and Ellsworth Huntington helped define the boundaries and significance of historical climatic regimes. When Francois Matthes wrote of a "little ice-age" in 1939, he was not creating a wholly new idea; he was instead engaging in a centuries-old debate over the climatic conditions of the last millennium.

Gilson, Christopher R.

2010-05-01T23:59:59.000Z

237

Computational Age Dating of Special Nuclear Materials  

SciTech Connect

This slide-show presented an overview of the Constrained Progressive Reversal (CPR) method for computing decays, age dating, and spoof detecting. The CPR method is: Capable of temporal profiling a SNM sample; Precise (compared with known decay code, such a ORIGEN); Easy (for computer implementation and analysis). ? We have illustrated with real SNM data using CPR for age dating and spoof detection. If SNM is pure, may use CPR to derive its age. If SNM is mixed, CPR will indicate that it is mixed or spoofed.

None

2012-06-30T23:59:59.000Z

238

Improving the reliability of the jpHMM recombination prediction in HIV  

Science Conference Proceedings (OSTI)

Accurate classification of HIV and the identification of recombinants, including precise breakpoint definitions, is of crucial importance for epidemiological monitoring and the design of potential drugs. Recently we developed jpHMM, a new method to detect recombinations in HIV-l genomes. jpHMM predicts phylogenetic recombination breakpoints in a query sequence and assigns to each segment of the sequence one of the major HIV-l subtypes. For the user the reliability of the predicted breakpoint positions and parental subtypes is most important. For this reason we extended the output of jpHMM to include the information on regions where the model is 'uncertain' about the parental subtype and an interval estimate of the breakpoint. This information is determined using the posterior probabilities of the subtypes at each query sequence position.

Zhang, Ming [Los Alamos National Laboratory; Letiner, Thomas K [Los Alamos National Laboratory; Korber, Bette T [Los Alamos National Laboratory

2008-01-01T23:59:59.000Z

239

Equal Access Initiative: HIV/AIDS Information Resources from the National Library of Medicine  

NLE Websites -- All DOE Office Websites (Extended Search)

Equal Access Initiative: Equal Access Initiative: HIV/AIDS Information Resources from the National Library of Medicine Instructors: Nicole Dancy, National Library of Medicine Wilma Templin-Branner, Oak Ridge Institute for Science and Education For Grantees of National Minority AIDS Council 2010 Equal Access Initiative Computer Grants Program United States Conference on AIDS September 11, 2010 2 Purpose ď‚„ To familiarize participants with reliable online health information from the National Library of Medicine and other reputable HIV/AIDS-related resources ď‚„ To empower participants with the skills and knowledge to better serve their clients, colleagues, and communities through the use of online HIV/AIDS-related resources 3 Objectives After completing this class, participants will be able to

240

On the stability of stationary age distributions  

Science Conference Proceedings (OSTI)

Age structured nonlinear single species and predator prey population models are treated and a straightforward relatively simple method is shown to arrive at a condition of stability of stationary solutions. Keywords: population dynamics, stability

M. Farkas

2002-09-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

International Forum for Reactor Aging Management (IFRAM)  

SciTech Connect

The Nuclear Regulatory Commission has undertaken a program to lay the groundwork for defining proactive actions to manage degradation of materials in light water reactors (LWRs). This article discusses the international forum for reactor aging management.

Bond, Leonard J.

2010-11-01T23:59:59.000Z

242

Chloride Depletion in Aged Sea Salt Particles  

NLE Websites -- All DOE Office Websites (Extended Search)

of how they formed, they transform as they are transported by the wind, showing signs of age by increasing in size, chemical complexity, and oxidation, as well as becoming more...

243

Aging of polymeric composites : a literature review  

E-Print Network (OSTI)

Due to their increased use in today's society, an extensive survey was undertaken in this report to condense what's been, thus far, discovered as to the effects of aging on polymeric composites. Special emphasis was placed ...

Trevińo-Garrido, Margie N

2013-01-01T23:59:59.000Z

244

ON THE AGE AND BINARITY OF FOMALHAUT  

SciTech Connect

The nearby (d = 7.7 pc) A3V star Fomalhaut is orbited by a resolved dusty debris disk and a controversial candidate extrasolar planet. The commonly cited age for the system (200 {+-} 100 Myr) from Barrado y Navascues et al. relied on a combination of isochronal age plus youth indicators for the K4V common proper-motion system TW PsA. TW PsA is 1.{sup 0}96 away from Fomalhaut and was first proposed as a companion by Luyten, but the physicality of the binarity is worth testing with modern data. I demonstrate that TW PsA is unequivocally a physical stellar companion to Fomalhaut, with true separation 0.280{sup +0.019}{sub -.012} pc (57.4{sup +3.9}{sub -2.5} kAU) and sharing velocities within 0.1 {+-} 0.5 km s{sup -1}-consistent with being a bound system. Hence, TW PsA should be considered 'Fomalhaut B'. Combining modern H-R diagram constraints with four sets of evolutionary tracks, and assuming the star was born with protosolar composition, I estimate a new isochronal age for Fomalhaut of 450 {+-} 40 Myr and mass of 1.92 {+-} 0.02 M{sub Sun }. Various stellar youth diagnostics are re-examined for TW PsA. The star's rotation, X-ray emission, and Li abundances are consistent with approximate ages of 410, 380, and 360 Myr, respectively, yielding a weighted mean age of 400 {+-} 70 Myr. Combining the independent ages, I estimate a mean age for the Fomalhaut-TW PsA binary of 440 {+-} 40 Myr. The older age implies that substellar companions of a given mass are approximately 1 mag fainter at IR wavelengths than previously assumed.

Mamajek, Eric E., E-mail: emamajek@ctio.noao.edu [Cerro Tololo Inter-American Observatory, Casilla 603, La Serena (Chile)

2012-08-01T23:59:59.000Z

245

Age problem in holographic dark energy  

E-Print Network (OSTI)

We study the age problem of the universe with the holographic DE model introduced in [21], and test the model with some known old high redshift objects (OHRO). The parameters of the model have been constrained using the SNIa, CMB and BAO data set. We found that the age of the old quasar APM 08 279+5255 at z = 3.91 can be described by the model.

L. N. Granda; A. Oliveros; W. Cardona

2009-05-12T23:59:59.000Z

246

HIV/AIDS Information Resources from the National Library of Medicine-STOP  

SciTech Connect

The HIV/AIDS Information Resources from the National Library of Medicine training is designed specifically for the UNCFSP HBCU Screening, Testing, Outreach, and Prevention (STOP) HIV/AIDS Program project members to provide valuable health information resources from the National Library of Medicine and other reliable sources to increase awareness of the wealth of treatment information and educational materials that are available on the Internet and to improve prevention and treatment education for their clients. These resources will also meet the needs of community-based organizations

Templin-Branner, W. and N. Dancy

2010-06-15T23:59:59.000Z

247

THE INITIAL MASS FUNCTION OF EARLY-TYPE GALAXIES  

Science Conference Proceedings (OSTI)

We determine an absolute calibration of the initial mass function (IMF) of early-type galaxies, by studying a sample of 56 gravitational lenses identified by the Sloan Lenses ACS Survey. Under the assumption of standard Navarro, Frenk, and White dark matter halos, a combination of lensing, dynamical, and stellar population synthesis models is used to disentangle the stellar and dark matter contribution for each lens. We define an 'IMF mismatch' parameter alphaident toM {sup LD}{sub *,Ein}/M {sup SPS}{sub *,Ein} as the ratio of stellar mass inferred by a joint lensing and dynamical model (M {sup LD}{sub *,Ein}) to the current stellar mass inferred from stellar populations synthesis models (M {sup SPS}{sub *,Ein}). We find that a Salpeter IMF provides stellar masses in agreement with those inferred by lensing and dynamical models ((log alpha) = -0.00 +- 0.03 +- 0.02), while a Chabrier IMF underestimates them ((log alpha) = 0.25 +- 0.03 +- 0.02). A tentative trend is found, in the sense that alpha appears to increase with galaxy velocity dispersion. Taken at face value, this result would imply a non-universal IMF, perhaps dependent on metallicity, age, or abundance ratios of the stellar populations. Alternatively, the observed trend may imply non-universal dark matter halos with inner density slope increasing with velocity dispersion. While the degeneracy between the two interpretations cannot be broken without additional information, the data imply that massive early-type galaxies cannot have both a universal IMF and universal dark matter halos.

Treu, Tommaso; Auger, Matthew W.; Gavazzi, Raphael; Marshall, Philip J. [Department of Physics, University of California, Santa Barbara, CA 93106 (United States); Koopmans, Leon V. E. [Kapteyn Institute, P.O. Box 800, 9700AV Groningen (Netherlands); Bolton, Adam S., E-mail: tt@physics.ucsb.ed, E-mail: mauger@physics.ucsb.ed, E-mail: pjm@physics.ucsb.ed, E-mail: koopmans@astro.rug.n, E-mail: gavazzi@iap.f, E-mail: bolton@ifa.hawaii.ed, E-mail: bolton@physics.utah.ed [Institute for Astronomy, University of Hawai'i, 2680 Woodlawn Dr., Honolulu, HI 96822 (United States)

2010-02-01T23:59:59.000Z

248

Overview of the ALCF Early Science Program  

NLE Websites -- All DOE Office Websites (Extended Search)

ALCF Early Science Program ALCF Early Science Program Timothy J . W illiams Argonne L eadership C ompu2ng F acility 2013 M iraCon W orkshop Wednesday 3 /4/2013 Session: 3 :45---4:30pm 2 § 16 projects - Large t arget a lloca-ons - Postdoc § Proposed r uns b etween M ira a cceptance a nd start of producCon § 2 billion core---hours to burn in a few months First in Mira Queue: Early Science Program h3p://esp.alcf.anl.gov 3 § MoCvaCons f or E SP: - Prepare k ey a pplica-ons f or t he a rchitecture a nd s cale o f M ira - Solidify l ibraries a nd i nfrastructure - Iden-fy s ystem p roblems § 16 Early Science projects were chosen based on computaConal and scienCfic reviews. § The p rojects h ave a r unning s tart f or d elivery o f e xciCng n ew s cience - Postdocs w ere a ssigned t o t he p rojects - ALCF

249

Early Science Instruction Addressing Fundamental Issues  

E-Print Network (OSTI)

Commentary Early Science Instruction Addressing Fundamental Issues David Klahr Carnegie Mellon (Vol. Eds.), Handbook of child psychology: Vol. 4. Child psychology in practice (6th ed.). New York acquisition in foundational domains. In W. Damon (Series Ed.) & D. Kuhn & R.S. Siegler (Vol. Eds.), Handbook

Klahr, David

250

Modeling early galaxies using radiation hydrodynamics  

Science Conference Proceedings (OSTI)

This simulation uses a flux-limited diffusion solver to explore the radiation hydrodynamics of early galaxies, in particular, the ionizing radiation created by Population III stars. At the time of this rendering, the simulation has evolved to a redshift ... Keywords: astrophysics, modeling, visualization

Joseph A. Insley; Rick Wagner; Robert Harkness; Daniel R. Reynolds; Michael L. Norman; Mark Hereld; Eric C. Olson; Michael E. Papka; Venkatram Vishwanath

2011-11-01T23:59:59.000Z

251

Toward Early Diagnosis of Lung Cancer  

Science Conference Proceedings (OSTI)

Our long term research goal is to develop a fully automated, image-based diagnostic system for early diagnosis of pulmonary nodules that may lead to lung cancer. In this paper, we focus on generating new probabilistic models for the estimated growth ...

Ayman El-Baz; Georgy Gimel'Farb; Robert Falk; Mohamed Abou El-Ghar; Sabrina Rainey; David Heredia; Teresa Shaffer

2009-10-01T23:59:59.000Z

252

A new perspective on early cosmology  

E-Print Network (OSTI)

We present a new perspective on early cosmology based on Loop Quantum Gravity. We use projected spinnetworks, coherent states and spinfoam techniques, to implement a quantum reduction of the full Kinematical Hilbert space of LQG, suitable to describe inhomogeneous cosmological models. Some preliminary results on the solutions of the Scalar constraint of the reduced theory are also presented.

Emanuele Alesci

2013-03-04T23:59:59.000Z

253

Those early days as we remember them (Part VI) - Met Lab & Early Argonne History  

NLE Websites -- All DOE Office Websites (Extended Search)

VI | Met Lab and Early Argonne History | Argonne National Laboratory VI | Met Lab and Early Argonne History | Argonne National Laboratory 1/2 Those early days as we remember them Part Vl Lester C. Furney (second from right), who formerly handled public relations at Argonne and is author of the article below, is pictured here in February 1956 with (l to r) Major General D. J. Keirn, Major General James McCormack, Jr. (Ret.), and Lt. General James H. Doolittle (Ret.) during a

254

Secondary state formation during the early iron age on the island of Sri Lanka : the evolution of a periphery  

E-Print Network (OSTI)

Universitario Orientale. MENDIS, G. C.1965. “The Vijayaand Dr. Asoka and Janine Mendis for their kind hospitality

Karunaratne, Priyantha Padmalal

2010-01-01T23:59:59.000Z

255

Feeding the periphery : modeling early Bronze Age economies and the cultural landscape of the Faynan District, Southern Jordan  

E-Print Network (OSTI)

Life of Palestine: Israel and Jordan. Ronald, New York.Use in the Wadi Faynan, Southern Jordan: The Third Season ofin the Wadi Faynan, Southern Jordan: The Second Season of

Muniz, Adolfo A.

2007-01-01T23:59:59.000Z

256

Age identity, gender, and perceptions of decline: Does feeling older lead to pessimistic dispositions about cognitive aging  

E-Print Network (OSTI)

Objectives. Drawing on past studies of age identity, this article examined whether feeling older was associated with more pessimistic views about cognitive aging. Methods. Using respondents aged 55 years and older in the Midlife Development in the United States study, we estimated a series of linear regression models to predict people ’ s dispositions toward their cognitive aging. The main comparison is whether the effects of age identity on cognitive aging differ for men and women. Results. Beyond the effects of chronological age, older age identities were associated with more pessimistic dispositions about cognitive aging. This relationship, however, was found only among women. Discussion. Age identity shapes cognitive aging dispositions, though the gendered nature of this relationship remains somewhat unclear. The findings give further evidence about the far-reaching implications of age identity for successful aging and suggest that future work can explicate how subjective aging processes may differ by gender.

Markus H. Schafer

2010-01-01T23:59:59.000Z

257

Short-Term Aging of Polymer Insulators: Dissection of Samples Aged in a Dry Environment  

Science Conference Proceedings (OSTI)

For many years, the Electric Power Research Institute (EPRI) has performed large-scale aging tests on polymer insulators and has evaluated many polymer insulators that have been removed from service, in an effort to understand what the aging factors are. EPRI has learned that a significant aging factor is corona discharge activity and has therefore developed a test that focuses on how corona discharge activity degrades polymer insulators. This report highlights the latest development of a short-term ...

2013-12-18T23:59:59.000Z

258

The Relative Ages of Galactic Globular Clusters  

E-Print Network (OSTI)

We present a review of the present state of knowledge regarding the relative ages of Galactic globular clusters. First, we discuss the relevant galaxy formation models and describe the detailed predictions they make with respect to the formation timescale and chemical evolution of the globular clusters. Next, the techniques used to estimate globular cluster ages are described and evaluated with particular emphasis on the advantages and disadvantages of each method. With these techniques as a foundation, we present arguments in favor of the following assertions: 1) The age of a globular cluster is the likeliest candidate to be the global second parameter, which along with metal abundance, controls the morphology of the horizonal branch. 2) A total age range of as much as $\\sim$5 Gyr exists among the bulk of the Galactic globulars. 3) There is a significant relation between age and metallicity among the Galactic globular clusters if the slope of the \\mvrr-\\feh relation is less than $\\sim$0.23. These conclusions along with other supporting evidence favor a formation scenario in which the inner regions of the Galactic halo collapsed in a monotonic fashion over a short time period much less than 1 Gyr. In contrast, the outer regions of the halo fragmented and collapsed in a chaotic manner over several Gyrs.

Ata Sarajedini; Brian Chaboyer; Pierre Demarque

1997-10-22T23:59:59.000Z

259

Results of LWR snubber aging research  

Science Conference Proceedings (OSTI)

This report describes the aging research results and recommendations for snubbers used in commercial nuclear power plants. Snubbers are safety-related devices used to restrain undesirable dynamic loads at various piping and equipment locations in nuclear power plants (NPPs). Each snubber must accommodate a plant's normal thermal movements and must be capable of restraining the maximum off-normal dynamic loads, such as a seismic event or a transient, postulated for its specific location. The effects of snubber aging and the factors that contribute to the degradation of their safety performance need to be better understood. Thus, Phase II of Nuclear Plant Aging Research was conducted to enhance the understanding of snubber aging and its consequences. Pacific Northwest Laboratory staff and their subcontractors, Lake Engineering and Wyle Laboratories, visited eight sites (encompassing thirteen plants) to conduct interviews with NPP staff and to collect data on snubber aging, testing, and maintenance. The Phase II research methodology, evaluation, results, conclusions, and recommendations are described in the report. Effective methods for service-life monitoring of snubbers are included in the recommendations.

Brown, D P [Lake Engineering Co., Greenville, RI (United States); Werry, E V; Blahnik, D E [Pacific Northwest Lab., Richland, WA (United States)

1992-05-01T23:59:59.000Z

260

Those early days as we remember them (Part IV) - Met Lab & Early...  

NLE Websites -- All DOE Office Websites (Extended Search)

Those early days as we remember them Part IV William P. Norris Division of Biological and Medical Research Ed. note: The following was transcribed from a tape recording made in...

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

High Temperature Aging Study on Long-Term Aged Alloy 617 and ...  

Science Conference Proceedings (OSTI)

In order to gain a better understanding of the high-temperature degradation process of these materials, long-term (up to 10000 hours) aging experiments have ...

262

Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies  

NLE Websites -- All DOE Office Websites (Extended Search)

Market Transformation Market Transformation Printable Version Share this resource Send a link to Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies to someone by E-mail Share Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Facebook Tweet about Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Twitter Bookmark Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Google Bookmark Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Delicious Rank Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on Digg Find More places to share Fuel Cell Technologies Office: Early Adoption of Fuel Cell Technologies on AddThis.com... Early Adoption of Fuel Cells Early Market Applications for Fuel Cells

263

Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach  

SciTech Connect

The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from the perspective of the virus has not previously been traced. In the current study we inferred the migration history of HIV-1 subtype B by way of a phylogeography of viral sequences sampled from 16 European countries and Israel. Migration events were inferred from viral phylogenies by character reconstruction using parsimony. With regard to the spatial dispersal of the HIV subtype B sequences across viral phylogenies, in most of the countries in Europe the epidemic was introduced by multiple sources and subsequently spread within local networks. Poland provides an exception where most of the infections were the result of a single point introduction. According to the significant migratory pathways, we show that there are considerable differences across Europe. Specifically, Greece, Portugal, Serbia and Spain, provide sources shedding HIV-1; Austria, Belgium and Luxembourg, on the other hand, are migratory targets, while for Denmark, Germany, Italy, Israel, Norway, the Netherlands, Sweden, Switzerland and the UK we inferred significant bidirectional migration. For Poland no significant migratory pathways were inferred. Subtype B phylogeographies provide a new insight about the geographical distribution of viral lineages, as well as the significant pathways of virus dispersal across Europe, suggesting that intervention strategies should also address tourists, travellers and migrants.

Leitner, Thomas [Los Alamos National Laboratory; Paraskevis, D [KATHOLIEKE UNIV; Pybus, O [UNIV OF OXFORD; Magiorkinis, G [KATHOLIEKE UNIV; Hatzakis, A [KATHOLIEKE UNIV

2008-01-01T23:59:59.000Z

264

Visualizing fusion of pseudotyped HIV-1 particles in real time by live cell microscopy  

E-Print Network (OSTI)

. Results We generated human immunodeficiency virus-1 (HIV-1) particles pseudotyped with the envelope (Env) protein of ecotropic murine leukemia virus eMLV to study retrovirus entry at the plasma membrane using live-cell microscopy. This Env protein mediates...

Koch, Peter; Lampe, Marko; Godinez, William J; Muller, Barbara; Rohr, Karl; Kraeusslich, Hans-Georg; Lehmann, Maik J

2009-09-18T23:59:59.000Z

265

Public Health ServiceINJECTION DRUG USE AND THE TRANSMISSION OF HIV  

E-Print Network (OSTI)

Preventing drug use and providing substance abuse treatment for persons who inject illicit drugs are crucial to preventing many blood-borne infections, including human immunodeficiency virus (HIV). However, many drug users are not currently in substance abuse treatment programs because of multiple factors including the limited availability of these programs and the lack of readiness or willingness of some drug users to enter substance abuse treatment. Consequently, substantial numbers of drug users continue to inject drugs. This bulletin summarizes new information on preventing transmission of HIV and other blood-borne infections among persons who inject drugs and updates prevention recommendations published in April 1993. *1 The findings of a 1995 workshop on the use of sterile syringes by persons who inject drugs and several recent publications 2,3,4,5,6 indicate that persons who inject drugs should use sterile syringes * * to prevent the transmission of HIV and other blood-borne infectious diseases. These conclusions should be considered by clinicians providing health care to persons who use or inject drugs and by public health professionals planning and carrying out HIV prevention programs for injection drug users (IDUs). Health professionals should inform IDUs that using sterile syringes is safer than reusing syringes, including syringes that have been disinfected with bleach. The information in this bulletin has been prepared for health professionals involved in programs serving persons who inject drugs. Separate educational materials will be prepared to inform drug injectors of these findings.

unknown authors

1997-01-01T23:59:59.000Z

266

How an Inhibitor of the HIV-I Protease Modulates Proteasome Activity*  

E-Print Network (OSTI)

How an Inhibitor of the HIV-I Protease Modulates Proteasome Activity* (Received for publication of a molecular target we found that Ritonavir inhibited the chymotryp- sin-like activity of the proteasome whereas the tryptic activity was enhanced. In this study we kinetically ana- lyzed how Ritonavir modulates

Bogyo, Matthew

267

Property:VolcanicAge | Open Energy Information  

Open Energy Info (EERE)

Property Property Edit with form History Facebook icon Twitter icon » Property:VolcanicAge Jump to: navigation, search Property Name VolcanicAge Property Type String Description Describes the time of the most recent volcanism by epoch, era, or period per available data. Subproperties This property has the following 7 subproperties: E East Mesa Geothermal Area G Geysers Geothermal Area L Lightning Dock Geothermal Area R Raft River Geothermal Area Roosevelt Hot Springs Geothermal Area S Salton Sea Geothermal Area Soda Lake Geothermal Area Pages using the property "VolcanicAge" Showing 19 pages using this property. A Amedee Geothermal Area + No volcanism + B Beowawe Hot Springs Geothermal Area + no volcanism + Blue Mountain Geothermal Area + no volcanism + Brady Hot Springs Geothermal Area + No volcanism +

268

Mesoscopic fluctuations and intermittency in aging dynamics  

E-Print Network (OSTI)

The configurational de-correlation in an aging system is attributed to irreversible intermittent rearrangements, which are described as a Poisson process with average $\\propto \\ln(1 + t/t_w)$, where $t$ is the observation time and $t_w$ is the age [P. Sibani and H.J. Jensen, Europhys. Lett. 69, 2005]. On this basis, we obtain a simple model for the off-equilibrium aging behavior of the autocorrelation: the average autocorrelation decays algebraically, and its shifted and rescaled probability density function (PDF) has a Gumbel-like shape which approaches a Gaussian at large times and becomes sharp in the thermodynamic limit. The model properties are tested against simulations of the Edwards-Anderson spin glass, and are in reasonable agreement with other available data.

Paolo Sibani

2005-06-07T23:59:59.000Z

269

The Shapes and Ages of Elliptical Galaxies  

E-Print Network (OSTI)

In this paper we investigate the relation between the detailed isophotal shape of elliptical galaxies and the strength of the H beta absorption in their spectra. We find that disky galaxies have higher H beta indices. Stellar population synthesis models show that the H beta line is a good age indicator, hence disky galaxies tend to have younger mean ages than boxy galaxies. We show that the observed trend can be brought about by a contaminating young population, which we associate with the disky component. This population need only account for a small fraction of the total mass, for example if a contaminating population of age of 2 Gyrs is superimposed on an old (12 Gyr) elliptical galaxy, then the observed trend can be explained if it contributes only 10% to the total mass. The size of this effect is consistent with the estimates of disk-to-total light ratios from surface photometry.

Roelof S. de Jong; Roger L. Davies

1996-11-13T23:59:59.000Z

270

EIA - Annual Energy Outlook 2011 Early Release  

Gasoline and Diesel Fuel Update (EIA)

April 2012 April 2012 | Report Number: DOE/EIA-0383ER(2012) This release is an abridged version of the Annual Energy Outlook that highlights changes in the AEO Reference case projections for key energy topics. The Early Release includes data tables for the Reference case only. The full AEO2011 will be released April 26, 2011. Download the AEO2011 Early Release Report Introduction In preparing the AEO2011, EIA evaluated a wide range of trends and issues that could have major implications for U.S. energy markets. This overview focuses primarily on one case, the AEO2011 Reference case, which is presented and compared with the AEO2010 Reference case released in December 2009 (see Table 1). Because of the uncertainties inherent in any energy market projection, the Reference case results should not be viewed in

271

EIA - Annual Energy Outlook 2008 (Early Release)  

Gasoline and Diesel Fuel Update (EIA)

Release) > Year-by-Year Reference Case Tables (2005-2030) Release) > Year-by-Year Reference Case Tables (2005-2030) Annual Energy Outlook 2008 with Projections to 2030 (Early Release) The early release version of the AEO2008 reference case does not include consideration of the H.R.6, "Energy Independence and Security Act of 2007," that was signed into law on December 19, 2007. EIA is compiling a revised reference case that includes the impact of H.R.6. Year-by-Year Reference Case Tables (2005-2030) Table Title Formats Summary Reference Case Tables Year-by-Year Reference Case Tables Table 1. Total Energy Supply and Disposition Summary Table 2. Energy Consumption by Sector and Source Table 3. Energy Prices by Sector and Source Table 4. Residential Sector Key Indicators and Consumption Table 5. Commercial Sector Indicators and Consumption

272

Regulatory Review of Early Site Permit Applications  

Science Conference Proceedings (OSTI)

The U.S. Nuclear Regulatory Commission (NRC) has received and is reviewing three applications for early site permits (ESPs). The ESP process allows early resolution of site-related issues affecting possible construction and operation of a new nuclear power plant. The nuclear industry views a successful and predictable ESP process as an important step in assessing whether to seek authorization to construct and operate a new generation of nuclear power reactors in the United States. Because consideration of ESP applications is a first-of-a-kind activity, a number of issues have emerged prior to and during the reviews of the first three applications. Issues have included the need for design information at the ESP stage, accident analyses, quality assurance, and seismic analyses. The NRC has been working to resolve identified issues to support a Commission decision on whether to issue an ESP approximately 33-37 months after receipt of each ESP application. (authors)

Scott, Michael L. [Senior Project Manager, Office of Nuclear Reactor Regulation, U.S. Nuclear Regulatory Commission, Washington, DC 20555 (United States)

2004-07-01T23:59:59.000Z

273

Early Site Permit Model Program Plan  

Science Conference Proceedings (OSTI)

"The Early Site Permit (ESP) Model Program Plan (MPP)" provides step-by-step guidelines on preparing an ESP application. The Plan identifies work tasks necessary to prepare the application and guides applicants on effectively planning and managing the ESP program, including identifying and managing subcontracted resources. A model program plan details how to prepare applications. The MPP also describes interfaces among tasks and provides a generic schedule for executing the steps in preparing an ESP appl...

2002-06-12T23:59:59.000Z

274

Aging behavior of polymeric solar absorber materials: Aging on the component level  

SciTech Connect

Within this study, the aging behavior of a PPE + PS absorber material was investigated on the absorber component level. To indicate aging, characteristic mechanical values were determined by indentation tests of specimens taken from components and exposed to laboratory aging (140 C in air, 80 C in water) and service near outdoor aging conditions (stagnation in northern climate). In addition to the mechanical tests, the unaged and aged specimens were also characterized thermo-analytically via differential scanning calorimetry (DSC). The results indicate that reductions in both characteristic mechanical values of the indentation tests, i.e., load of the first transition and ultimate indentation, reflect at least some physical aging although chemical aging may also be of importance based on previous analytical investigations of laboratory aged polymer films. While laboratory aging in air at 140 C and service exposure at a test facility in Oslo (N) under stagnation conditions led to a significant reduction in the mechanical indentation resistance, no influence of laboratory aging in water at 80 C on the mechanical behavior of the absorber sheet was found. Depending on the ultimate failure criterion applied (reduction of characteristic mechanical values to 80% and 50%, respectively), the technical service life found for hot air laboratory and stagnation service conditions was found to be less than 51 and 159 h, respectively. As these durations are significantly below the estimated stagnation conditions accumulated in the desired operation lifetime for such a collector, the PPE + PS type investigated does not seem to be a proper material candidate for solar thermal absorbers. Finally, based on the results obtained, a relation between laboratory aging time in air at 140 C and cumulated irradiation energy during exposure on the test facility in Oslo was established. (author)

Kahlen, S. [Polymer Competence Center Leoben GmbH, Roseggerstrasse 12, A-8700 Leoben (Austria); Wallner, G.M.; Lang, R.W. [Institute for Polymeric Materials and Testing, University of Linz, Altenbergerstrasse 69, A-4040 Linz (Austria); Meir, M.; Rekstad, J. [Department of Physics, University of Oslo, P.O. Box 1048, Blindern, N-0316 Oslo (Norway)

2010-03-15T23:59:59.000Z

275

Redshifted 21-cm Signals in the Dark Ages  

E-Print Network (OSTI)

We have carried out semianalytic simulations to build redshifted 21-cm maps in the dark ages. An entropy-floor model is adopted for planting protogalaxies in simulated minihaloes. The model allocates gas quantities such as baryonic mass and temperature to every $N$-body particle and extensively exploits the particle nature of the data in the subsequent analysis. We have found that the number density of simulated minihaloes in the early universe is well described by the Sheth & Tormen function and consequently the signal powers of simulated minihaloes are far greater than the Press & Schechter prediction presented by Furlanetto (2006b). Even though the matter power spectrum measured in the halo particles at $z=15$ is about an order of magnitude smaller than the intergalactic medium (IGM), the 21-cm signal fluctuations of haloes are, to the contrary, one order of magnitude higher than the embedding adiabatic IGM on scales, $k\\lesssim 10 h{\\rm Mpc}^{-1}$. But their spectral shapes are almost same to each...

Kim, Juhan

2009-01-01T23:59:59.000Z

276

Understanding the Emotions of Others: Loss or Gain in Aging?  

E-Print Network (OSTI)

theory. Psychology and Aging, 7(3), 331-8. Carstensen, L.2007). The Handbook of Aging and Cognition: Third Edition (The Posterior-Anterior Shift in Aging. Cereb. Cortex, 18(5),

Sze, Jocelyn Andrea

2010-01-01T23:59:59.000Z

277

Effect of Modified Aging Treatments on the Tensile Properties ...  

Science Conference Proceedings (OSTI)

These include i) lowering the artificial aging temperature ii) interrupted aging cycles similar to T6I4 referred to in the published literature and iii) artificial aging in ...

278

Aging and Gene Expression in the Primate Brain  

E-Print Network (OSTI)

Issue 9 | e274 Primate Brain Aging mask ?le for chimpanzee185 p. 2. Harman D (1956) Aging: A theory based on freeThe free radical theory of aging matures. Physiol Rev 78:

Fraser, Hunter B.; Khaitovich, Philipp; Plotkin, Joshua B.; Paabo, Svante; Eisen, Michael B.

2005-01-01T23:59:59.000Z

279

Aging and Fracture of Human Cortical Bone and Tooth Dentin  

E-Print Network (OSTI)

et al. , The effect of aging on crack-growth resistance andR.K. Reprogel, Effects of aging on the mechanical behaviorNalla et al. , Effect of aging on the toughness of human

Ager III, Joel W.

2008-01-01T23:59:59.000Z

280

INCREASED STRENGTHENING OF AUSTENITIC ALLOYS THROUGH DUAL AGING  

E-Print Network (OSTI)

d o - - -700°C after first aging at 745°C /2 hr tween) (nobJ,J". _.J__ __JI (TOTAL) AGING TIME (hr) XBL Figure 22 aALLOYS THROUGH DUAL AGING Annie Ma Inorganic Materials

Ma, Annie

2011-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

The Geneva-Copenhagen Survey of the Solar neighbourhood II. New uvby calibrations and rediscussion of stellar ages, the G dwarf problem, age-metallicity diagram, and heating mechanisms of the disk  

E-Print Network (OSTI)

Ages, metallicities, space velocities, and Galactic orbits of stars in the Solar neighbourhood are fundamental observational constraints on models of galactic disk evolution. We aim to consolidate the calibrations of uvby photometry into Te, [Fe/H], distance, and age for F and G stars and rediscuss the results of the Geneva-Copenhagen Survey (Nordstrom et al. 2004; GCS) in terms of the evolution of the disk. We substantially improve the Te and [Fe/H] calibrations for early F stars, where spectroscopic temperatures have large systematic errors. Our recomputed ages are in excellent agreement with the independent determinations by Takeda et al. (2007), indicating that isochrone ages can now be reliably determined. The revised G-dwarf metallicity distribution remains incompatible with closed-box models, and the age-metallicity relation for the thin disk remains almost flat, with large and real scatter at all ages (sigma intrinsic = 0.20 dex). Dynamical heating of the thin disk continues throughout its life; specific in-plane dynamical effects dominate the evolution of the U and V velocities, while the W velocities remain random at all ages. When assigning thick and thin-disk membership for stars from kinematic criteria, parameters for the oldest stars should be used to characterise the thin disk.

J. Holmberg; B. Nordstrom; J. Andersen

2007-07-13T23:59:59.000Z

282

Electronic games for aged care and rehabilitation  

Science Conference Proceedings (OSTI)

The declining cognitive and motor abilities has become a major problem in the health care of the elderly, often leading to potentially fatal falls. Current rehabilitation strategies to address this issue include routine physiotherapy which is often dull ... Keywords: aged care, rehabilitation, software agent, video game

Stuart T. Smith; Amir Talaei-Khoei; Mililani Ray; Pradeep Ray

2009-12-01T23:59:59.000Z

283

Privacy, Technology, and Aging: A Proposed Framework  

E-Print Network (OSTI)

the development, adoption, and use of home-based ubiquitous technologies for older adults. We began with a five, adoption, and use of home-based ubiquitous technologies are highly contextual, individualized and aging can inform the development of a privacy framework for home-based technologies that can contribute

Camp, L. Jean

284

Molecular Clocks: Determining the Age of  

E-Print Network (OSTI)

Molecular Clocks: Determining the Age of the Human­Chimpanzee Divergence Michael I Jensen `molecular clock') allows for the estimation of the time of divergence between modern species, dependent on calibrating the clock with known divergence dates from the fossil record. The molecular clock gives dates

Seaman, Michael I.

285

Epidemiology of HIV Among Injecting and Non-injecting Drug Users: Current Trends and Implications for Interventions  

E-Print Network (OSTI)

might inject drugs worldwide [1•]. China, the United States,China, the United States, and Russia, the three leading countries for injecting drugChina Russia USA Fig. 1 Number and proportion of HIV infection among injecting drug

Strathdee, Steffanie A.; Stockman, Jamila K.

2010-01-01T23:59:59.000Z

286

Examining Public Health System Responses to the Chronic Diseases of HIV/AIDS and Diabetes: Experiences from Mexico and Brazil  

E-Print Network (OSTI)

A. Cohn, Health reform in Brazil: lessons to consider. Am JPetersen, M.L. , et al. , Brazil, in The HIV Pandemic: localof the AIDS epidemic in Brazil: principal epidemiological

Gidi, Virginia Eve

2010-01-01T23:59:59.000Z

287

Investigations of silica alcogel aging using coherent light  

NLE Websites -- All DOE Office Websites (Extended Search)

Investigations of silica alcogel aging using coherent light Title Investigations of silica alcogel aging using coherent light Publication Type Journal Article Year of Publication...

288

Accelerated Aging of Roofing Surfaces | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Accelerated Aging of Roofing Surfaces Accelerated Aging of Roofing Surfaces Emerging Technologies Project for the 2013 Building Technologies Office's Program Peer Review...

289

On the Aging Behavior of AA2618 DC Cast Alloy  

Science Conference Proceedings (OSTI)

The aging behavior of the non-deformed alloy at artificial and natural aging conditions was studied. The precipitation characteristics of the alloy were studied by ...

290

Groundwater Age-Dating for Water Resource Characterization  

The LLNL Groundwater Noble Gas Mass Spectrometry Facility and Capability offers: Less model-dependent than tritium age dating: Traditional tritium age ...

291

The role of glycation in aging and diabetes mellitus  

Science Conference Proceedings (OSTI)

Abstract. One of the hypotheses trying to explain the process of aging is the idea of ... vated blood sugar levels, show signs of accelerated aging exposing similar ...

292

The Effectiveness of Direct Aging on INCONEL 718 Forgings ...  

Science Conference Proceedings (OSTI)

Direct aging (DA) is a synonym for hardening of an Inconel 718 forging after the fosming operation and applying a two step aging procedure coninion for Inconel

293

More on Early ENSOs: Evidence from Australian Documentary Sources  

Science Conference Proceedings (OSTI)

Early documentary records of the British colony of New South Wales, Australia, have been examined for evidence of droughts. The years of occurrence of these early droughts were compared with the chronologies of El Niñ:o-Southern Oscillation ...

Neville Nicholls

1988-01-01T23:59:59.000Z

294

Civil Laws and Civil Justice in Early China  

E-Print Network (OSTI)

and the Body in Early China. Leiden: E.J. Brill, 2004. DuReinterpretation of Xiao. ” Early China 20 (1995): 195-222.Crisis and Conflict in Han China. London: George Allen and

Zhang, Zhaoyang

2010-01-01T23:59:59.000Z

295

Presidential Early Career Award for Scientists and Engineers  

Science Conference Proceedings (OSTI)

... interests center on science underlying future energy technologies, especially those ... Early Career Awards for Scientists and Engineers, the highest ...

2010-10-05T23:59:59.000Z

296

Method for early detection of infectious mononucleosis  

DOE Patents (OSTI)

Early detection of infectious mononucleosis is carried out using a sample of human blood by isolating and identifying the presence of Inmono proteins in the sample from a two-dimensional protein map with the proteins being characterized by having isoelectric banding as measured in urea of about -16 to -17 with respect to certain isoelectric point standards and molecular mass of about 70 to 75 K daltons as measured in the presence of sodium dodecylsulfate containing polyacrylamide gels, the presence of the Inmono proteins being correlated with the existence of infectious mononucleosis.

Willard, K.E.

1982-08-10T23:59:59.000Z

297

Those early days as we remember them (part I) - Met Lab and Argonne's Early  

NLE Websites -- All DOE Office Websites (Extended Search)

History >Those early days as we remember them (Part I) History >Those early days as we remember them (Part I) About Director's Welcome Organization Achievements Highlights Fact Sheets, Brochures & Other Documents Multimedia Library Visit Argonne Work with Argonne Contact us Nuclear Energy Why Nuclear Energy? Why are some people afraid of Nuclear Energy? How do nuclear reactors work? Cheaper & Safer Nuclear Energy Helping to Solve the Nuclear Waste Problem Nuclear Reactors Nuclear Reactors Early Exploration Training Reactors Basic and Applied Science Research LWR Technology Development BORAX-III lighting Arco, Idaho (Press Release) Heavy Water and Graphite Reactors Fast Reactor Technology Integral Fast Reactor Argonne Reactor Tree CP-1 70th Anniversary CP-1 70th Anniversary Argonne's Nuclear Science and Technology Legacy

298

Those early days as we remember them - Met Lab and Argonne's Early History  

NLE Websites -- All DOE Office Websites (Extended Search)

and Early and Early History About Director's Welcome Organization Achievements Highlights Fact Sheets, Brochures & Other Documents Multimedia Library Visit Argonne Work with Argonne Contact us Nuclear Energy Why Nuclear Energy? Why are some people afraid of Nuclear Energy? How do nuclear reactors work? Cheaper & Safer Nuclear Energy Helping to Solve the Nuclear Waste Problem Nuclear Reactors Nuclear Reactors Early Exploration Training Reactors Basic and Applied Science Research LWR Technology Development BORAX-III lighting Arco, Idaho (Press Release) Heavy Water and Graphite Reactors Fast Reactor Technology Integral Fast Reactor Argonne Reactor Tree CP-1 70th Anniversary CP-1 70th Anniversary Argonne's Nuclear Science and Technology Legacy Argonne's Nuclear Science and Technology Legacy

299

Managing Aging Effects on Dry Cask Storage  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Managing Aging Effects Managing Aging Effects on Dry Cask Storage Systems for Extended Long-Term Storage and Transportation of Used Fuel Rev. 0 Prepared for U.S. Department of Energy Used Fuel Disposition Campaign O.K. Chopra, D. Diercks, R. Fabian, D. Ma, V. Shah, S-W Tam, and Y.Y. Liu Argonne National Laboratory June 30, 2012 FCRD-USED-2012-000119 ANL-12/29 DISCLAIMER This information was prepared as an account of work sponsored by an agency of the U.S. Government. Neither the U.S. Government nor any agency thereof, nor any of their employees, makes any warranty, expressed or implied, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness, of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately

300

Why could ice ages be unpredictable?  

E-Print Network (OSTI)

It is commonly accepted that the variations of Earth's orbit and obliquity control the timing of Pleistocene glacial-interglacial cycles. Evidence comes from power spectrum analysis of palaeoclimate records and from inspection of the timing of glacial and deglacial transitions. However, we do not know how tight this control is. Is it, for example, conceivable that random climatic fluctuations could cause a delay in deglaciation, bad enough to skip a full precession or obliquity cycle and subsequently modify the sequence of ice ages? To address this question, seven previously published conceptual models of ice ages are analysed by reference to the notion of generalised synchronisation. Insight is being gained by comparing the effects of the astronomical forcing with idealised forcings composed of only one or two periodic components. In general, the richness of the astronomical forcing allows for synchronisation over a wider range of parameters, compared to periodic forcing. Hence, glacial cycles may conceivably have remained paced by the astronomical forcing throughout the Pleistocene. However, all the models examined here also show a range of parameters for which the structural stability of the ice age dynamics is weak. This means that small variations in parameters or random fluctuations may cause significant shifts in the succession of ice ages if the system were effectively in that parameter range. Whether or not the system has strong structural stability depends on the amplitude of the effects associated with the astronomical forcing, which significantly differ across the different models studied here. The possibility of synchronisation on eccentricity is also discussed and it is shown that a high Rayleigh number on eccentricity, as recently found in observations, is no guarantee of reliable synchronisation.

Michel Crucifix

2013-02-06T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

Welcome to Early Science Program Investigators Meeting  

NLE Websites -- All DOE Office Websites (Extended Search)

Early Science Program Early Science Program Investigators Meeting Timothy J . W illiams Argonne L eadership C ompu2ng F acility 2 At Argonne, Safety is First! § In c ase o f a n e mergency o r i njury, d ial 9 11 f rom t he building p hones, o r d ial 6 30---252---1911 f rom c ell p hones. § Fire: A lways b e a ware o f t he n earest e xit. - If t he b uilding a larms s ound, e vacuate t he b uilding a nd p roceed t o the r eloca9on a rea ( building 2 13). - If a s ite---wide a larm s ounds, f ollow t he d irec9ons i ssued o ver t he public a nnouncement s ystem. § Tornado: I n t he e vent o f a t ornado, a t one a nd announcement will come from the public announcement s ystem. S eek s helter i mmediately i n t he nearest s tairwell. § Smoking i n n ot p ermiLed i n b uilding 2 40. S moking i s permiLed o nly i n t he d esignated

302

Energy implications of an aging population  

Science Conference Proceedings (OSTI)

This study provides various demographic, medical, and economic information relative to energy usage on a segment of the population, the elderly, which is growing in absolute numbers and relative population percentage. This growth is expected to continue well into the twenty-first century. The US aging population numbered 3.1 million in 1900, and by 1977 it had climbed to 23.5 million. It can be stated with reasonable certainty that this figure will rise to 31 million in the year 2000 and 43 million in the year 2020. These figures, corresponding to more than 10% of our population, are by no means insignificant. As our fossil-fuel reserves are being depleted and the cost of energy mounts, it becomes apparent that the elderly will become increasingly vulnerable to the energy crisis, primarily beause of their physical tendency to infirmity, their economic and social situation, and their susceptibility to psychological depression. This white paper concentrates on those aspects of aging and the nation's energy problem which are not usually related in our everyday consideration of these as separable problems. It seeks to identify the peculiar energy problems of the aged and to consider alternatives in the solution of these problems in light of modern technology.

Not Available

1980-08-01T23:59:59.000Z

303

Aging Studies of VCE Dismantlement Returns  

Science Conference Proceedings (OSTI)

VCE is an ethylene/vinyl acetate/vinyl alcohol terpolymer binder for filled elastomers which is designed to accept high filler loadings. Filled elastomer parts consist of the binder (VCE), a curing agent (Hylene MP, diphenol-4-4{prime}-methylenebis(phenylcarbamate)), a processing aid (LS, lithium stearate), and filler particles (typically 70% fraction by weight). The curing of the filled elastomer parts occurs from the heat-activated reaction between the hydroxyl groups of VCE with the Hylene MP curing agent, resulting in a cross-linked network. The final vinyl acetate content is typically between 34.9 and 37.9%, while the vinyl alcohol content is typically between 1.27 and 1.78%. Surveillance data for this material is both scarce and scattered, complicating the assessment of any aging trends in systems. In addition, most of the initial surveillance efforts focused on mechanical properties such as hardness and tensile strength, and chemical information is therefore lacking. Material characterization and aging studies had been performed on previous formulations of the VCE material but the Ethylene Vinyl Acetate (EVA) starting copolymer is no longer commercially available. New formulations with replacement EVA materials are currently being established and will require characterization as well as updated aging models.

Letant, S; Alviso, C; Pearson, M; Albo, R; Small, W; Wilson, T; Chinn, S; Maxwell, R

2011-10-17T23:59:59.000Z

304

IMPACT OF PHYSICAL AGING ON THE CRAZE INITIATION ...  

Science Conference Proceedings (OSTI)

IMPACT OF PHYSICAL AGING ON THE CRAZE INITIATION AND PROPAGATION IN STYRENE ACRYLONITRILE CO-POLYMER. ...

305

Toward Automatic Simulation of Aging Effects on Face Images  

Science Conference Proceedings (OSTI)

The process of aging causes significant alterations in the facial appearance of individuals. When compared with other sources of variation in face images, appearance variation due to aging displays some unique characteristics. For example, aging variation ... Keywords: aging variation, statistical face models, face recognition

A. Lanitis; C. J. Taylor; T. F. Cootes

2002-04-01T23:59:59.000Z

306

Are Refiners Entering a Golden Age or a Short Cycle?  

U.S. Energy Information Administration (EIA)

Are Refiners Entering a Golden Age or a Short Cycle? Global Refining Strategies 2007 Barcelona, Spain

307

On Ocean Transport Diagnostics: The Idealized Age Tracer and the Age Spectrum  

Science Conference Proceedings (OSTI)

The idealized age tracer is commonly used to diagnose transport in ocean models and to help interpret ocean measurements. In most studies only the steady-state distribution, the result of many centuries of model integration, has been presented ...

Timothy M. Hall; Thomas W. N. Haine

2002-06-01T23:59:59.000Z

308

Fuel Cell Technologies Office: Early Market Applications for Fuel Cell  

NLE Websites -- All DOE Office Websites (Extended Search)

Market Transformation Market Transformation Printable Version Share this resource Send a link to Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies to someone by E-mail Share Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Facebook Tweet about Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Twitter Bookmark Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Google Bookmark Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Delicious Rank Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on Digg Find More places to share Fuel Cell Technologies Office: Early Market Applications for Fuel Cell Technologies on AddThis.com...

309

Absolute Ages of Globular Clusters and the Age of the Universe  

E-Print Network (OSTI)

The main sequence turnoff luminosity is the best stellar `clock' which can be used to determine the absolute ages of globular clusters. This is due to the fact that it is generally assumed that the luminosity and lifetimes of main sequence globular cluster stars are independent of the properties of stellar convection and atmospheres, two areas of stellar evolution which are poorly understood. Several possible sources of error in this stellar clock are discussed, and isochrones are constructed using a variety of different physical assumptions. The mean age of the oldest globular clusters are determined from these isochrones and it is found that the uncertainties in the input physics can lead to changes in the derived age of $\\pm 15\\%$. Surprisingly the largest source of error is the mixing length theory of convection. It is well known that uncertainties in the distance scale and chemical composition of globular cluster stars lead to changes of order $\\sim 22\\%$ in the determination of absolute ages. Combining the various sources of error, the absolute age of the oldest globular clusters are found to lie in the range 11 --- 21 Gyr. This is meant to be a total theoretical range. For the standard inflationary model ($\\Omega = 1, \\Lambda = 0$), a minimum age of the universe of 11 Gyr requires $H_o \\la 60~\\kmsmpc$.

Brian Chaboyer

1994-12-06T23:59:59.000Z

310

Aging by epigenetics-A consequence of chromatin damage?  

Science Conference Proceedings (OSTI)

Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.

Sedivy, John M. [Brown University, Division of Biology and Medicine, Laboratories for Molecular Medicine, 70 Ship Street, Providence, RI 02903 (United States)], E-mail: john_sedivy@brown.edu; Banumathy, Gowrishankar [Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 (United States); Adams, Peter D. [Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 (United States)], E-mail: peter.adams@fccc.edu

2008-06-10T23:59:59.000Z

311

Nuclear Matrix protein SMAR1 represses HIV-1 LTR mediated transcription through chromatin remodeling  

SciTech Connect

Nuclear Matrix and MARs have been implicated in the transcriptional regulation of host as well as viral genes but their precise role in HIV-1 transcription remains unclear. Here, we show that > 98% of HIV sequences contain consensus MAR element in their promoter. We show that SMAR1 binds to the LTR MAR and reinforces transcriptional silencing by tethering the LTR MAR to nuclear matrix. SMAR1 associated HDAC1-mSin3 corepressor complex is dislodged from the LTR upon cellular activation by PMA/TNFalpha leading to an increase in the acetylation and a reduction in the trimethylation of histones, associated with the recruitment of RNA Polymerase II on the LTR. Overexpression of SMAR1 lead to reduction in LTR mediated transcription, both in a Tat dependent and independent manner, resulting in a decreased virion production. These results demonstrate the role of SMAR1 in regulating viral transcription by alternative compartmentalization of LTR between the nuclear matrix and chromatin.

Sreenath, Kadreppa; Pavithra, Lakshminarasimhan; Singh, Sandeep; Sinha, Surajit [National Centre for Cell science, University of Pune Campus, Ganeshkhind, Pune 411007, Maharashtra (India); Dash, Prasanta K.; Siddappa, Nagadenahalli B.; Ranga, Udaykumar [Molecular Virology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore (India); Mitra, Debashis [National Centre for Cell science, University of Pune Campus, Ganeshkhind, Pune 411007, Maharashtra (India); Chattopadhyay, Samit, E-mail: samit@nccs.res.i [National Centre for Cell science, University of Pune Campus, Ganeshkhind, Pune 411007, Maharashtra (India)

2010-04-25T23:59:59.000Z

312

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield  

SciTech Connect

The HIV envelope (Env) protein gp120 is protected from antibody recognition by a dense glycan shield. However, several of the recently identified PGT broadly neutralizing antibodies appear to interact directly with the HIV glycan coat. Crystal structures of antigen-binding fragments (Fabs) PGT 127 and 128 with Man{sub 9} at 1.65 and 1.29 angstrom resolution, respectively, and glycan binding data delineate a specific high mannose-binding site. Fab PGT 128 complexed with a fully glycosylated gp120 outer domain at 3.25 angstroms reveals that the antibody penetrates the glycan shield and recognizes two conserved glycans as well as a short {beta}-strand segment of the gp120 V3 loop, accounting for its high binding affinity and broad specificify. Furthermore, our data suggest that the high neutralization potency of PGT 127 and 128 immunoglobulin Gs may be mediated by cross-linking Env trimers on the viral surface.

Pejchal, Robert; Doores, Katie J.; Walker, Laura M.; Khayat, Reza; Huang, Po-Ssu; Wang, Sheng-Kai; Stanfield, Robyn L.; Julien, Jean-Philippe; Ramos, Alejandra; Crispin, Max; Depetris, Rafael; Katpally, Umesh; Marozsan, Andre; Cupo, Albert; Maloveste, Sebastien; Liu, Yan; McBride, Ryan; Ito, Yukishige; Sanders, Rogier W.; Ogohara, Cassandra; Paulson, James C.; Feizi, Ten; Scanlan, Christopher N.; Wong, Chi-Huey; Moore, John P.; Olson, William C.; Ward, Andrew B.; Poignard, Pascal; Schief, William R.; Burton, Dennis R.; Wilson, Ian A. (Progenics); (JSTA); (UWASH); (Scripps); (NIH); (Weill); (Oxford); (ICL)

2011-12-05T23:59:59.000Z

313

THE INTERACTING EARLY-TYPE BINARY V382 Cyg  

Science Conference Proceedings (OSTI)

We analyze photometric and spectroscopic data and study the orbital period of the early-type interacting binary system V382 Cyg by using all the available data. We obtain a simultaneous light and radial velocity curve solution. The derived physical parameters of the primary and secondary stellar components are M{sub 1} = 27.9(5) M{sub Sun }, M{sub 2} = 20.8(4) M{sub Sun }, R{sub 1} = 9.7(2) R{sub Sun }, R{sub 2} = 8.5(2) R{sub Sun }, log ({sub 1}/L{sub Sun }) = 5.152(20), and log (L{sub 2}/L{sub Sun }) = 4.954(19) while the separation of the components is a = 23.4 R{sub Sun }. Newly obtained parameters yield the distance of the system to be 1466(76) pc. Analyses of the mid-eclipse times indicate a period increase of dP/dt = 4.2(1) Multiplication-Sign 10{sup -7} days yr{sup -1} that can be interpreted in terms of the high-mass transfer (dM/dt 6.1(5) Multiplication-Sign 10{sup -6} M{sub Sun} yr{sup -1}) from the less massive component to the more massive component. Finally, we model the evolution of the components using non-conservative codes and discuss the results obtained. The age of the binary system is estimated to be 3.85 Myr.

Yasarsoy, B.; Yakut, K. [Department of Astronomy and Space Sciences, University of Ege, 35100 Bornova-Izmir (Turkey)

2013-01-01T23:59:59.000Z

314

Innovative practices in early childhood classrooms: what makes a teacher an early adopter?  

E-Print Network (OSTI)

This basic qualitative research study focused on the internal constructions of ten early childhood education teachers who take new information acquired from workshops, coursework, or other educational venues and quickly incorporate it into their teaching. The participants were all women who work in a variety of classroom settings with two-through-six-year-olds in San Antonio, Texas. They were identified as teachers who are in the forefront in adopting new ideas in comparison to other early childhood teachers (Rogers, 2003). A wide range of experience and education levels were represented. Using the interpretive paradigm as well as the ideological framework of constructivism, a grounded theory was established in response to the research question. Of special interest were factors that can be addressed in pre-service and in-service instructional opportunities for early childhood students and professionals. There were three major findings. First, the participants expressed core moral values in relation to their jobs as early childhood teachers: they look upon their work as a moral endeavor; they have a spiritual connection to their work; and they care deeply about others. Second, they shared the character traits of a positive attitude, persistence, and flexibility. Third, they held two learning dispositions in common: they perceive and practice learning as a continual, on-going process; and they are highly reflective. Viewed together, these three findings form a continuous internal loop that impacts the external cycle of gaining new information and adopting it into classroom practice. The findings in this study parallel previous teacher knowledge research done with K-12 grade teachers in the United States and in other countries. It supports models of change that consider one's frame of reference in terms of individual belief systems and how this impacts the change process. The implication is that focusing on technical knowledge is not enough. Early childhood teacher educators must consistently employ specific strategies with their students that help illuminate and strengthen the tacit traits identified in this study.

Marshall, Ellen

2006-05-01T23:59:59.000Z

315

Prince, RJ. 2012. HIV and the Moral Economy of Survival in an East African City.  

E-Print Network (OSTI)

Kenya experienced some of the highest HIV prevalence and AIDS-related mortality rates in east Africa.1 At that time antiretroviral therapy (ART) remained prohibitively expensive. This situation changed in 2004, when the U.S. Presidential Emergency... harsh side effects, exacerbated if taken on an empty stomach. It is known that ART interacts with the body’s nutrition and its energy needs as well as its immunity (Hardon et al. 2007), and medical advice stresses that eating well is essential...

Prince, Ruth J.

2012-01-01T23:59:59.000Z

316

EIA - Annual Energy Outlook 2013 Early Release  

Gasoline and Diesel Fuel Update (EIA)

Annual Energy Outlook 2013 Annual Energy Outlook 2013 Release Dates: April 15 - May 2, 2013 | Next Early Release Date: December 2013 (See release cycle changes) | correction | full report Overview Data Reference Case Side Cases Interactive Table Viewer Topics Source Oil/Liquids Natural Gas Coal Electricity Renewable/Alternative Nuclear Sector Residential Commercial Industrial Transportation Energy Demand Other Emissions Prices Macroeconomic International Efficiency Publication Chapter Market Trends Issues in Focus Legislation & Regulations Comparison Appendices Table Title Formats Summary Reference Case Tables Year-by-Year Reference Case Tables Table 1. Total Energy Supply and Disposition Summary Table 2. Energy Consumption by Sector and Source Table 3. Energy Prices by Sector and Source Table 4. Residential Sector Key Indicators and Consumption

317

EIA - Annual Energy Outlook 2012 Early Release  

Gasoline and Diesel Fuel Update (EIA)

Economic growth Economic growth Recovery from the 2008-2009 recession is expected to show the slowest growth of any recovery since 1960. Table 2 compares average annual growth rates over a five-year period following U.S. recessions that have occurred since 1960. For the most recent recession, the expected five-year average annual growth rate in real GDP from 2009 to 2014 is 1.3 percentage points below the corresponding average for the three past recessions, with consumption and non-farm employment recovering even more slowly. The slower growth in the early years of the projection has implications for the long term, with a lower economic growth rate leading to a slower recovery in employment and higher unemployment rates. Real GDP in 2035 is 4 percent lower in the AEO2012 Reference case than was projected in the AEO2011

318

Earth's early atmosphere  

SciTech Connect

Ideas about atmospheric composition and climate on the early Earth have evolved considerably over the last 30 years, but many uncertainties still remain. It is generally agreed that the atmosphere contained little or no free oxygen initially and that oxygen concentrations increased markely near 2.0 billion years ago, but the precise timing of and reasons for its rise remain unexplained. Likewise, it is usually conceded that the atmospheric greenhouse effect must have been higher in the past to offset reduced solar luminosity, but the levels of atmospheric carbon cioxide and other greenhouse gases required remain speculative. A better understanding of past atmospheric evolution is important to understanding the evolution of life and to predicting whether Earth-like planets might exist elsewhere in the galaxy.

Kasting, J.F. (Pennsylvania State Univ., University Park (United States))

1993-02-12T23:59:59.000Z

319

EIA - Annual Energy Outlook 2013 Early Release  

Gasoline and Diesel Fuel Update (EIA)

Electricity Generation Electricity Generation Total electricity consumption in the AEO2013 Reference case, including both purchases from electric power producers and on-site generation, grows from 3,841 billion kilowatthours in 2011 to 4,930 billion kilowatthours in 2040, an average annual rate of 0.9 percent-about the same rate as in the AEO2012 Reference case through 2035. The combination of slow growth in electricity demand, competitively priced natural gas, programs encouraging renewable fuel use, and the implementation of new environmental rules dampens future coal use. The AEO2013 Reference case assumes implementation of the CAIR as a result of an August 2012 federal court decision to vacate the CSAPR. The lower natural gas prices in the early years of the AEO2013 Reference case result in

320

Early Cook County Roads -- Part Two  

NLE Websites -- All DOE Office Websites (Extended Search)

Two Two Nature Bulletin No. 739 January 18, 1964 Forest Preserve District of Cook County Seymour Simon, President Roberts Mann, Conservation Editor EARLY COOK COUNTY ROADS -- PART TWO -- THE PLANK ROAD ERA For ten years after Chicago, with a population of 4,170, was chartered as a city in 1837, its commerce and growth were crippled by wretched transportation to and from the hinterlands. During many periods of each year it was surrounded and isolated by mud. To be sure, there were dirt thoroughfares in all directions, graded and drained as best they could in those days, but not surfaced. No one who has never experienced it can appreciate how gooey and gluey a black prairie soil can be when wet. A wagon's wheels often become solid cylinders of mud as wide as a bass drum.

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While these samples are representative of the content of NLEBeta,
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We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

EIA - Annual Energy Outlook 2014 Early Release  

Gasoline and Diesel Fuel Update (EIA)

Executive Summary Executive Summary Projections in the Annual Energy Outlook 2014 (AEO2014) Reference case focus on the factors that shape U.S. energy markets through 2040, under the assumption that current laws and regulations remain generally unchanged throughout the projection period. The early release provides a basis for the examination and discussion of energy market trends and serves as a starting point for analysis of potential changes in U.S. energy policies, rules, or regulations or possible technology breakthroughs. Readers are encouraged to review the full range of cases that will be presented when the complete AEO2014 is released in 2014, exploring key uncertainties in the Reference case. Major highlights of the AEO2014 Reference case include: Growing domestic production of natural gas and crude oil continues to

322

2017 Levelized Costs AEO 2012 Early Release  

Gasoline and Diesel Fuel Update (EIA)

2018 Levelized Costs AEO 2013 1 2018 Levelized Costs AEO 2013 1 January 2013 Levelized Cost of New Generation Resources in the Annual Energy Outlook 2013 This paper presents average levelized costs for generating technologies that are brought on line in 2018 1 as represented in the National Energy Modeling System (NEMS) for the Annual Energy Outlook 2013 (AEO2013) Early Release Reference case. 2 Both national values and the minimum and maximum values across the 22 U.S. regions of the NEMS electricity market module are presented. Levelized cost is often cited as a convenient summary measure of the overall competiveness of different generating technologies. It represents the per-kilowatthour cost (in real dollars) of building and operating a generating plant over an assumed financial life and duty cycle. Key

323

EIA - Annual Energy Outlook 2013 Early Release  

Gasoline and Diesel Fuel Update (EIA)

Annual Energy Outlook 2013 Annual Energy Outlook 2013 Release Dates: April 15 - May 2, 2013 | Next Early Release Date: December 16, 2013 (See release cycle changes) | correction | full report Overview Data Reference Case Side Cases Interactive Table Viewer Topics Source Oil/Liquids Natural Gas Coal Electricity Renewable/Alternative Nuclear Sector Residential Commercial Industrial Transportation Energy Demand Other Emissions Prices Macroeconomic International Efficiency Publication Chapter Market Trends Issues in Focus Legislation & Regulations Comparison Appendices Table Title Formats Summary Reference Case Tables Year-by-Year Reference Case Tables Table 1. Total Energy Supply and Disposition Summary Table 2. Energy Consumption by Sector and Source Table 3. Energy Prices by Sector and Source Table 4. Residential Sector Key Indicators and Consumption

324

Transient-mediated fate determination in a transcriptional circuit of HIV  

Science Conference Proceedings (OSTI)

Steady-state behavior and bistability have been proposed as mechanisms for decision-making in gene circuits1-3. However, transient gene expression has also been proposed to control cell fate4, 5 with the decision arbitrated by the lifetime of the expression transient. Here, we report that transcriptional positive-feedback plays a critical role in determining HIV infected cell-fate by extending the duration of Tat expression transients6, 7 far beyond what protein half-life modulation can achieve. To directly quantify feedback strength and its effects on the duration of Tat transcriptional pulses, we exploit the noise inherent to gene-expression and measure shifts in the autocorrelation of expression noise. The results indicate that transcriptional positive-feedback extends the single-cell Tat expression lifetime by 2-to 6-fold for both minimal Tat circuits and full-length, actively-replicating HIV-1. Importantly, artificial weakening of Tat positive-feedback shortened the duration of Tat expression transients and biased the probability in favor of latency. Thus, transcriptional positive-feedback appears to modulate transient expression lifetime and thereby control cell-fate in HIV.

Weinberger, Leor S. [University of California, San Diego; Dar, Roy D. [University of Tennessee, Knoxville (UTK); Simpson, Michael L [ORNL

2008-01-01T23:59:59.000Z

325

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity  

SciTech Connect

Antibody 2G12 uniquely neutralizes a broad range of HIV-1 isolates by binding the high-mannose glycans on the HIV-1 surface glycoprotein, gp120. Antigens that resemble these natural epitopes of 2G12 would be highly desirable components for an HIV-1 vaccine. However, host-produced (self)-carbohydrate motifs have been unsuccessful so far at eliciting 2G12-like antibodies that cross-react with gp120. Based on the surprising observation that 2G12 binds nonproteinaceous monosaccharide D-fructose with higher affinity than D-mannose, we show here that a designed set of nonself, synthetic monosaccharides are potent antigens. When introduced to the terminus of the D1 arm of protein glycans recognized by 2G12, their antigenicity is significantly enhanced. Logical variation of these unnatural sugars pinpointed key modifications, and the molecular basis of this increased antigenicity was elucidated using high-resolution crystallographic analyses. Virus-like particle protein conjugates containing such nonself glycans are bound more tightly by 2G12. As immunogens they elicit higher titers of antibodies than those immunogenic conjugates containing the self D1 glycan motif. These antibodies generated from nonself immunogens also cross-react with this self motif, which is found in the glycan shield, when it is presented in a range of different conjugates and glycans. However, these antibodies did not bind this glycan motif when present on gp120.

Doores, Katie J.; Fulton, Zara; Hong, Vu; Patel, Mitul K.; Scanlan, Christopher N.; Wormald, Mark R.; Finn, M.G.; Burton, Dennis R.; Wilson, Ian A.; Davis, Benjamin G. (Scripps); (Oxford)

2011-08-24T23:59:59.000Z

326

Anti-Oxidants, Omega-3 Fatty Acids, and Cognitive Decline with Aging  

E-Print Network (OSTI)

neurobiology of cognitive aging”. Ageing Research Reviewsinterventions. Neurobiology of Aging , 133-136. Cutler, R.1991). Antioxidants and aging. American Journal of Clinical

Patel, Tanu Ashok

2011-01-01T23:59:59.000Z

327

The star formation history of early-type galaxies as a function of mass and environment  

E-Print Network (OSTI)

Using the third data release of the Sloan Digital Sky Survey (SDSS) we have rigorously defined a volume limited sample of early-type galaxies in the redshift range z environment for each galaxy using a method which takes account of the redshift bias introduced by survey boundaries if traditional methods are used. At luminosities greater than our absolute r-band magnitude cutoff of -20.45 the mean density of environment shows no trend with redshift. We calculate the Lick indices for the entire sample and correct for aperture effects and velocity dispersion in a model independent way. Although we find no dependence of redshift or luminosity with environment we do find that the mean velocity dispersion, sigma, of early-type galaxies in dense environments tends to be higher than in low density environments. Taking account of this effect we find that several indices show small but very significant trends with environment that are not the result of the correlation between indices and velocity dispersion. The statistical significance of the data is sufficiently high to reveal that models accounting only for alpha-enhancement struggle to produce a consistent picture of age and metallicity of the sample galaxies, whereas a model that also includes carbon enhancement fares much better. We find that early-type galaxies in the field are younger than those in environments typical of clusters but that neither metallicity, alpha-enhancement nor carbon enhancement are influenced by the environment. The youngest early-type galaxies in both field and cluster environments are those with the lowest sigma. However, there is some evidence that the objects with the largest sigma are slightly younger, especially in denser environments.

M. S. Clemens; A. Bressan; B. Nikolic; P. Alexander; F. Annibali; R. Rampazzo

2006-03-27T23:59:59.000Z

328

www.thelancet.com/lancetgh Vol 1 November 2013 e251 Mapping HIV epidemics in sub-Saharan Africa with use of  

E-Print Network (OSTI)

of the prevalence of infection could be constructed. This map would then be overlaid on a grid map that showsComment www.thelancet.com/lancetgh Vol 1 November 2013 e251 Mapping HIV epidemics in sub-infected individuals with antiretroviral therapy will reduce HIV transmission, because it decreases viral load

Blower, Sally

329

Sheri A. Lippman, PhD, PI Reaching transgender women with home-based, self-HIV testing in San Francisco: a pilot  

E-Print Network (OSTI)

Sheri A. Lippman, PhD, PI Reaching transgender women with home-based, self-HIV testing in San home-based self-administered HIV testing for transwomen in three phases. Two focus groups the first attempt to systematically examine acceptability, feasibility, preferences, and support for home-based

Klein, Ophir

330

A DESIGN GUIDE FOR EARLY-MARKET ELECTROCHROMIC WINDOWS  

NLE Websites -- All DOE Office Websites (Extended Search)

EARLY-MARKET ELECTROCHROMIC WINDOWS PIER FINAL PROJECT REPORT Prepared For: California Energy Commission Public Interest Energy Research Program Prepared By: Lawrence Berkeley...

331

Presidential Early Career Awards for Scientists and Engineers (PECASE) |  

Office of Science (SC) Website

Presidential Early Presidential Early Career Awards for Scientists and Engineers (PECASE) About Organization Budget Field Offices Federal Advisory Committees History Scientific and Technical Information Honors & Awards Presidential Early Career Awards for Scientists and Engineers (PECASE) DOE's Winners Since 1996 Ceremony The Enrico Fermi Award The Ernest Orlando Lawrence Award DOE Nobel Laureates Federal Laboratory Consortium Excellence in Technology Transfer Award R&D 100 Awards Jobs Brochures, Logos, & Information Resources Contact Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 P: (202) 586-5430 Honors & Awards Presidential Early Career Awards for Scientists and Engineers (PECASE) Print Text Size: A A A RSS Feeds

332

Three Early Twentieth Century Tango Songs Arranged for Brass Quintet.  

E-Print Network (OSTI)

??Despite a quickly growing repertoire list for the brass quintet, the music of the early Argentine tango has remained relatively neglected by brass quintet arrangers… (more)

Camacho, Gustavo

2011-01-01T23:59:59.000Z

333

Clean Energy Finance: Challenges and Opportunities of Early-Stage...  

NLE Websites -- All DOE Office Websites (Extended Search)

2 Executive Summary Clean Energy Finance-Challenges and Opportunities of Early-Stage Energy Investing - Executive Summary NREL Industry Growth Forum The premier event for clean...

334

Clean Energy Finance: Challenges and Opportunities of Early-Stage...  

NLE Websites -- All DOE Office Websites (Extended Search)

1 Clean Energy Finance-Challenges and Opportunities of Early-Stage Energy Investing Disclaimer: the analysis and recommendations presented are solely those of the researchers...

335

Nuclear engineer Li wins Presidential Early Career Award | Argonne...  

NLE Websites -- All DOE Office Websites (Extended Search)

Photon Source. Click to enlarge. Argonne's Advanced Photon Source. Click to enlarge. Nuclear engineer Li wins Presidential Early Career Award By Jared Sagoff * January 15, 2014...

336

Employment Impacts of Early Markets for Hydrogen and Fuel Cell...  

NLE Websites -- All DOE Office Websites (Extended Search)

Source: Kurtz, J., K. Wipke, S. Sprik, T. Ramsden and C. Ainscough, Early Fuel Cell Market Deployments: ARRA and Combined (IAA, DLA, ARRA) NREL Composite Data Products, March...

337

EIA - Annual Energy Outlook 2013 Early Release  

U.S. Energy Information Administration (EIA)

Projections in the Annual Energy Outlook 2013 ... This early release focuses on the AEO2013 Reference case, ... Topics Analysis & Projections Environment

338

LANL, LLNL researchers among Early Career Research Program award...  

NLE Websites -- All DOE Office Websites (Extended Search)

Follow this link to skip to the main content Facebook Flickr RSS Twitter YouTube LANL, LLNL researchers among Early Career Research Program award recipients | National Nuclear...

339

Four Argonne National Laboratory scientists receive Early Career...  

NLE Websites -- All DOE Office Websites (Extended Search)

Four Argonne National Laboratory scientists receive Early Career Research Program awards By Brian Grabowski * May 10, 2012 Tweet EmailPrint ARGONNE, Ill. - Four researchers at the...

340

Coal Fuels Alliance: Design and Construction of Early Lead Mini...  

NLE Websites -- All DOE Office Websites (Extended Search)

Coal Fuels Alliance: Design and Construction of Early Lead Mini Fischer-Tropsch Refinery University of Kentucky Center for Applied Energy Research (CAER) Project Number: NT0005988...

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Energy age wind ltd Co KG | Open Energy Information  

Open Energy Info (EERE)

age wind ltd Co KG age wind ltd Co KG Jump to: navigation, search Name energy-age-wind ltd & Co. KG Place Telgte, Germany Zip 48291 Sector Wind energy Product Energy-age-wind aims to develop small scale vertical-axis wind turbines. References energy-age-wind ltd & Co. KG[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. energy-age-wind ltd & Co. KG is a company located in Telgte, Germany . References ↑ "energy-age-wind ltd & Co. KG" Retrieved from "http://en.openei.org/w/index.php?title=Energy_age_wind_ltd_Co_KG&oldid=344826" Categories: Clean Energy Organizations Companies Organizations Stubs What links here Related changes Special pages Printable version

342

Influence of Thermal Aging on Microstructure and Mechanical ...  

Science Conference Proceedings (OSTI)

The as-aged samples were subject to aging treatment for 1100h and 3000h at 600?, 1100h at 650?, after normalizing at 980? for 30min and tempering at ...

343

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Enzyme Structure Provides Insights into Cancer and Aging Enzyme Structure Provides Insights into Cancer and Aging Print Wednesday, 25 February 2009 00:00 XPD helicase is an enzyme...

344

Managing Aging Effects on Dry Cask Storage Systems for Extended...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Managing Aging Effects on Dry Cask Storage Systems for Extended Long Term Storage and Transportation of Used Fuel Rev0 Managing Aging Effects on Dry Cask Storage Systems for...

345

Aging Aluminum Alloy 7085 Mold Blocks Part II: Continuous ... - TMS  

Science Conference Proceedings (OSTI)

Jun 1, 2007 ... Aging Aluminum Alloy 7085 Mold Blocks Part II: Continuous Non-Isothermal Aging by J.T. Staley, Sr., E. Austin, D.B. Glanton, B. Godin, and G.

346

Aging Aluminum Alloy 7085 Mold Blocks Part 1 - TMS  

Science Conference Proceedings (OSTI)

Jun 1, 2007 ... Aging Aluminum Alloy 7085 Mold Blocks Part 1: Two-Step Aging by J.T. Staley; Sr.; H. Conrad; W. Crill; J. Grossman; and F. Skaria ...

347

From aging infrastructure to the unaparalleled UPF | Y-12 National...  

NLE Websites -- All DOE Office Websites (Extended Search)

From aging infrastructure ... From aging infrastructure to the unaparalleled UPF Posted: February 7, 2013 - 6:14pm | Y-12 Report | Volume 9, Issue 2 | 2013 The Uranium Processing...

348

Authority, polity, and tenuous elites in Iron Age Edom (Jordan)  

E-Print Network (OSTI)

the Iron Age in southern Jordan (Shef?eld), 47–54. knauf, e.at Tawilan in southern Jordan (Oxford). bienkowski, p.the Iron Age in southern Jordan: A framework. In Bienkowski,

Porter, Benjamin W.

2004-01-01T23:59:59.000Z

349

Age Dating of Mixed SNM--Preliminary Investigations  

SciTech Connect

Recently we investigated the nuclear forensics problem of age determination for mixed special nuclear material (SNM). Through limited computational mixing experiments and interactive age analysis, it was observed that age dating results are generally affected by the mixing of samples with different assays or even by small radioactive material contamination. The mixing and contamination can be detected through interactive age analysis, a function provided by the Decay Interaction, Visualization and Analysis (DIVA) software developed by NSTec. It is observed that for mixed SNM with two components, the age estimators typically fall into two distinct clusters on the time axis. This suggests that averaging or other simple statistical methods may not always be suitable for age dating SNM mixtures. Instead, an interactive age analysis would be more suitable for age determination of material components of such SNM mixtures. This work was supported by the National Center for Nuclear Security (NCNS).

Yuan, D., Guss, P. P., Yfantis, E., Klingensmith, A., Emer, D.

2011-12-01T23:59:59.000Z

350

Space-Age Ceramics Get Their Toughest Test  

NLE Websites -- All DOE Office Websites (Extended Search)

Space-Age Ceramics Get Their Toughest Test Space-Age Ceramics Get Their Toughest Test Print Wednesday, 17 April 2013 07:23 Advanced ceramic composites can withstand the ultrahigh...

351

Aging, phase ordering and conformal invariance  

E-Print Network (OSTI)

In a variety of systems which exhibit aging, the two-time response function scales as $R(t,s)\\approx s^{-1-a} f(t/s)$. We argue that dynamical scaling can be extended towards conformal invariance, obtaining thus the explicit form of the scaling function $f$. This quantitative prediction is confirmed in several spin systems, both for $T

Malte Henkel; Michel Pleimling; Claude Godreche; Jean-Marc Luck

2001-07-13T23:59:59.000Z

352

Differential aging from acceleration, an explicit formula  

E-Print Network (OSTI)

We consider a clock 'paradox' framework where an observer leaves an inertial frame, is accelerated and after an arbitrary trip comes back. We discuss a simple equation that gives, in the 1+1 dimensional case, an explicit relation between the time elapsed on the inertial frame and the acceleration measured by the accelerating observer during the trip. A non-closed trip with respect to an inertial frame appears closed with respect to another suitable inertial frame. Using this observation we define the differential aging as a function of proper time and show that it is non-decreasing. The reconstruction problem of special relativity is also discussed showing that its, at least numerical, solution would allow the construction of an 'inertial clock'.

E. Minguzzi

2004-11-25T23:59:59.000Z

353

Dark Energy in the Dark Ages  

E-Print Network (OSTI)

Non-negligible dark energy density at high redshifts would indicate dark energy physics distinct from a cosmological constant or ``reasonable'' canonical scalar fields. Such dark energy can be constrained tightly through investigation of the growth of structure, with limits of \\la2% of total energy density at z\\gg1 for many models. Intermediate dark energy can have effects distinct from its energy density; the dark ages acceleration can be constrained to last less than 5% of a Hubble e-fold time, exacerbating the coincidence problem. Both the total linear growth, or equivalently \\sigma_8, and the shape and evolution of the nonlinear mass power spectrum for zenergy behavior over the entire range z=0-1100.

Eric V. Linder

2006-03-21T23:59:59.000Z

354

Early Cook County Roads -- Part One  

NLE Websites -- All DOE Office Websites (Extended Search)

One One Nature Bulletin No. 738 January 11, 1964 Forest Preserve District of Cook County Seymour Simon, President Roberts Mann, Conservation Editor EARLY COOK COUNTY ROADS -- PARK ONE When Chicago was incorporated as a village in 1833 it was only a squalid hamlet of about 350 inhabitants and appeared to be so poorly situated that it was hopeless -- "crude cabins and flimsy shacks in a chaos of mud, rubbish and confusion. " Only a few feet above the level of Lake Michigan, the place was almost entirely surrounded by swamps and miles and miles of prairies that became nearly impassable after spring thaws and during periods of heavy rainfall. There were only two important routes that afforded access at all times. One was the Green Bay Trail, ancestor of North Clark St. in Chicago, Ridge Ave. in Evanston, and Green Bay Road north of that. The other, traveled by the soldiers coming from Detroit to build Fort Dearborn in 1803, used the Great Sauk Trail to La Porte, Indiana, then a trail northwesterly to what is now Michigan City, and the firm sands of the lake beach the rest of the way.

355

Default assembly of early adenovirus chromatin  

SciTech Connect

In adenovirus particles, the viral nucleoprotein is organized into a highly compacted core structure. Upon delivery to the nucleus, the viral nucleoprotein is very likely to be remodeled to a form accessible to the transcription and replication machinery. Viral protein VII binds to intra-nuclear viral DNA, as do at least two cellular proteins, SET/TAF-I{beta} and pp32, components of a chromatin assembly complex that is implicated in template remodeling. We showed previously that viral DNA-protein complexes released from infecting particles were sensitive to shearing after cross-linking with formaldehyde, presumably after transport of the genome into the nucleus. We report here the application of equilibrium-density gradient centrifugation to the analysis of the fate of these complexes. Most of the incoming protein VII was recovered in a form that was not cross-linked to viral DNA. This release of protein VII, as well as the binding of SET/TAF-I{beta} and cellular transcription factors to the viral chromatin, did not require de novo viral gene expression. The distinct density profiles of viral DNA complexes containing protein VII, compared to those containing SET/TAF-I{beta} or transcription factors, were consistent with the notion that the assembly of early viral chromatin requires both the association of SET/TAF-1{beta} and the release of protein VII.

Spector, David J. [Department of Microbiology and Immunology, Intercollege Graduate Degree Program in Genetics, and Cellular and Molecular Biology Program, Pennsylvania State University College of Medicine, Hershey, PA 17033 (United States)]. E-mail: dspector@psu.edu

2007-03-01T23:59:59.000Z

356

Aging in attraction-driven colloidal glasses  

E-Print Network (OSTI)

Aging in an attraction-driven colloidal glass is studied by computer simulations. The system is equilibrated without attraction and instantaneously ``quenched'', at constant colloid volume fraction, to one of two states beyond the glass transition; one is close to the transition, and the other one deep in the glass. The evolution of structural properties shows that bonds form in the system, increasing the local density, creating density deficits (holes) elsewhere. This process slows down with the time elapsed since the quench. As a consequence of bond formation, there is a slowing down of the dynamics, as measured by the mean squared displacement and the density, bond, and environment correlation functions. The density correlations can be time-rescaled to collapse their long time (structural) decay. The time scale for structural relaxation shows for both quenches a super-linear dependence on waiting time; it grows faster than the bond lifetime, showing the collective origin of the transition. At long waiting times and high attraction strength, we observe {\\rem completely} arrested dynamics for more than three decades in time, although individual bonds are not permanent on this time scale. The localization length decreases as the state moves deeper in the glass; the non-ergodicity parameter oscillates in phase with the structure factor. Our main results are obtained for systems with a barrier in the pair potential that inhibits phase separation. However, when this barrier is removed for the case of a deep quench, we find changes in the static structure but almost none in the dynamics. Hence our results for the aging behavior remain relevant to experiments in which the glass transition competes with phase separation.

Antonio M. Puertas; Matthias Fuchs; Michael E. Cates

2006-03-24T23:59:59.000Z

357

Center for Demography of Health and Aging at the University of Wisconsin (P30 AG017266).2  

E-Print Network (OSTI)

Infant mortality at birth may help illuminate the usefulness of season of birth as an indicator of early life exposures. We obtained data for infant mortality rates (IMR) at the county (municipio) level during the late 1920s-early 1940s in Puerto Rico using historical records and linked IMR with individual birth year and place using the PREHCO (Puerto Rican Elderly: Health Conditions) study. We classified PREHCO respondents into two groups according to high or low infectious disease load, corresponding to lower or higher proportion endogenous mortality in the year respondents were born. We estimated the effects of IMR (using continuous, logit, quartile, Box-Cox transformations) and season of birth on adult heart disease and diabetes for all respondents and then by subgroups, controlling for age, gender, obesity, respondent’s educational level, adult behavior (smoking, exercise) and other early life exposures (childhood health, knee height, childhood SES). Findings: (1) no significant associations between IMR and heart disease or diabetes but significant associations between high IMR and low knee height, low education, older age and no rigorous exercise as an adult; (2) stronger effects of season of birth on adult health among respondents born in years with lower infectious disease loads; (3) strong

Mary Mceniry; Mary Mceniry

2009-01-01T23:59:59.000Z

358

Aging Effects on Craze Growth Under Stress Relaxation ...  

Science Conference Proceedings (OSTI)

Aging Effects on Craze Growth Under Stress Relaxation Conditions. Mats Delin and Gregory B. McKenna, Polymers Division ...

359

Evolution of local dynamics and mechanical aging in soft ...  

Science Conference Proceedings (OSTI)

... Evolution of local dynamics and mechanical aging in soft solids. James Harden, The Johns Hopkins University. This talk ...

360

Accelerated Environmental Aging Effects and In-Situ ...  

Science Conference Proceedings (OSTI)

Page 1. Accelerated Environmental Aging Effects and In-Situ Functional Testing of Commercial Photovoltaic Modules T ...

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Cable Aging Management Training Course for Low-Voltage Cables  

Science Conference Proceedings (OSTI)

The "EPRI PSE Cable Aging Training Course for Low-Voltage Cables" provides a basis for understanding of the aging of the insulation and jackets of electrical cables used in low-voltage systems. Practical techniques for determining which cables are prone to premature aging and for evaluating their condition are described. The course contains 11 modules. The first 9 modules describe the body of the cable aging management process. The last two modules, "Cable Failure Assessment" and "Performing a Walkdown o...

2003-11-24T23:59:59.000Z

362

Transportation, Aging and Disposal Canister System Performance Specification: Revision 1  

Energy.gov (U.S. Department of Energy (DOE))

This document provides specifications for selected system components of the Transportation, Aging and Disposal (TAD) canister-based system.

363

The Changing Face of Healthcare in the Electronic Age  

Science Conference Proceedings (OSTI)

The Changing Face of Healthcare in the Electronic Age Post Hearing Questions Submission by NIST. Question 1: As part ...

2013-09-24T23:59:59.000Z

364

Atomistic Predictions of Age Hardening in Al-Cu Alloys  

Science Conference Proceedings (OSTI)

Atomic Scale Deformation Mechanisms of Amorphous Polyethylene under Tensile Loading · Atomistic Predictions of Age Hardening in Al-Cu Alloys.

365

Theoretical Uncertainties in the Subgiant--Mass Age Relation and the Absolute Age of Omega Cen  

E-Print Network (OSTI)

The theoretical uncertainties in the calibration of the relationship between the subgiant mass and age in metal-poor stars are investigated using a Monte Carlo approach. Assuming that the mass and iron abundance of a subgiant star are known exactly, uncertainties in the input physics used to construct stellar evolution models and isochrones lead to a Gaussian 1-sigma uncertainty of +/-2.9% in the derived ages. The theoretical error budget is dominated by the uncertainties in the calculated opacities. Observations of detached double lined eclipsing binary OGLEGC-17 in the globular cluster Omega Cen have found that the primary is on the subgiant branch with a mass of M = 0.809+/-0.012 M_sun and [Fe/H]= -2.29+/-0.15 (Kaluzny et al. 2001). Combining the theoretical uncertainties with the observational errors leads to an age for OGLEGC-17 of 11.10+/-0.67 Gyr. The one-sided, 95% lower limit to the age of OGLEGC-17 is 10.06 Gyr, while the one-sided, 95% upper limit is 12.27 Gyr.

Brian Chaboyer; Lawrence M. Krauss

2002-01-28T23:59:59.000Z

366

Comparison of HIV-, HBV-, HCV- and Co-Infection Prevalence between Chinese and Burmese Intravenous Drug Users of the China-Myanmar Border Region  

E-Print Network (OSTI)

Background: Co-infection with HIV and HCV and/or HBV is highly prevalent in intravenous drug users (IDUs). Because of the proximity to the ‘‘Golden Triangle’’, HIV prevalence among the IDUs is very high in the China-Myanmar border region. However, there are few studies about co-infection with HIV and HCV and/or HBV, especially in the region that belongs to Myanmar. Methods: 721 IDUs, including 403 Chinese and 318 Burmese, were investigated for their HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) serological status. Statistical analysis was performed to evaluate the differences of the epidemic situation between the Chinese IDUs and the Burmese IDUs. Results: Among the Chinese IDUs and the Burmese IDUs, HCV infection was the most prevalent (69.0 % vs 48.1%, P,0.001), followed by HBV (51.6 % vs 43.1%, P,0.05) and HIV (33.7 % vs 27.0%, P.0.05). Besides, there were more HIV-HBV co-infected IDUs (20.1 % vs 11.3%, P,0.005), and HIV-HCV co-infected IDUs (31.8 % vs 23.9%, P,0.05) in China than in Myanmar, as well as HIV-HBV-HCV triple infection (19.1 % vs 10.4%, P,0.005). Conclusion: Co-infection with HIV and HCV and/or HBV is highly prevalent among the IDUs in the China-Myanmar border region. The HIV epidemic appears to be in a downward trend, compared with previous reports. However, all infections were

Yan-heng Zhou; Feng-liang Liu; Zhi-hong Yao; Lin Duo; Hong Li; Yi Sun

2010-01-01T23:59:59.000Z

367

http://roa.sagepub.com/ Research on Aging  

E-Print Network (OSTI)

http://roa.sagepub.com/ Research on Aging http://roa.sagepub.com/content/32/4/499 The online online 5 March 2010Research on Aging Sheila Feld, Ruth E. Dunkle, Tracy Schroepfer and Huei-Wern Shen Spouses Published by: http://www.sagepublications.com can be found at:Research on AgingAdditional services

Wisconsin at Madison, University of

368

Genetics of Aging in Caenorhabditis elegans Adam Antebi  

E-Print Network (OSTI)

Review Genetics of Aging in Caenorhabditis elegans Adam Antebi ABSTRACT A dissection of longevity Over the last 20 years, fundamental insights into the biology of aging have emerged through the study, the discovery that the single gene mutants age-1 and daf-2 could extend the short three-week life span 1­2-fold

Rosenberg, Noah

369

Time and Aging: A Physicist's Look at Gerontology  

E-Print Network (OSTI)

CHAPTER 6 Time and Aging: A Physicist's Look at Gerontology Jos Uffink To enter as a physicist physics has lots of interesting things to say about time, it has very little to say about aging. Moreover, the little it has to say about aging has no practical relevance for gerontology. I will avoid trying

Seevinck, Michiel

370

Designing robotic avatars: are user's impression affected by avatar's age?  

Science Conference Proceedings (OSTI)

This paper explores the relationship between the aging cue of a robotic avatar and the level of intelligence and safety perceived by the elderly as users. This initial study found that the avatar aging cue indeed, affects the elderly in their perception ... Keywords: aging cue, avatar, elderly, embodied agent, interfaces, robotics, user experience

Angie Lorena Marin Mejia; Doori Jo; Sukhan Lee

2013-03-01T23:59:59.000Z

371

Aging, Estrogen Loss and Epoxyeicosatrienoic Acids Alison R. Lee1.  

E-Print Network (OSTI)

Aging, Estrogen Loss and Epoxyeicosatrienoic Acids (EETs) Alison R. Lee1. , Angela S. Pechenino1 loss, caused by menopause, and aging have inflammatory consequences. Epoxyeicosatrienoic acids (EETs cyclooxygenases and lipoxygenases. We hypothesized that aging and estrogen loss would reduce levels of anti

Hammock, Bruce D.

372

THE ROLE OF AGING AND ONCE-THROUGH-COOLED POWER  

E-Print Network (OSTI)

CALIFORNIA ENERGY COMMISSION THE ROLE OF AGING AND ONCE-THROUGH-COOLED POWER PLANTS IN CALIFORNIA Nyberg, Darryl Metz, Connie Leni. 2009. The Role of Aging and Once-Through-Cooled Power Plants .................................................................................................................5 CHAPTER 2: California's Aging and Once-Through-Cooled Plants

373

IS ACTIVE REGION CORE VARIABILITY AGE DEPENDENT?  

Science Conference Proceedings (OSTI)

The presence of both steady and transient loops in active region cores has been reported from soft X-ray and extreme-ultraviolet observations of the solar corona. The relationship between the different loop populations, however, remains an open question. We present an investigation of the short-term variability of loops in the core of two active regions in the context of their long-term evolution. We take advantage of the nearly full Sun observations of STEREO and Solar Dynamics Observatory spacecraft to track these active regions as they rotate around the Sun multiple times. We then diagnose the variability of the active region cores at several instances of their lifetime using EIS/Hinode spectral capabilities. We inspect a broad range of temperatures, including for the first time spatially and temporally resolved images of Ca XIV and Ca XV lines. We find that the active region cores become fainter and steadier with time. The significant emission measure at high temperatures that is not correlated with a comparable increase at low temperatures suggests that high-frequency heating is viable. The presence, however, during the early stages, of an enhanced emission measure in the ''hot'' (3.0-4.5 MK) and ''cool'' (0.6-0.9 MK) components suggests that low-frequency heating also plays a significant role. Our results explain why there have been recent studies supporting both heating scenarios.

Ugarte-Urra, Ignacio [College of Science, George Mason University, 4400 University Drive, Fairfax, VA 22030 (United States); Warren, Harry P. [Space Science Division, Naval Research Laboratory, Washington, DC 20375 (United States)

2012-12-10T23:59:59.000Z

374

TESTING A PREDICTION OF THE MERGER ORIGIN OF EARLY-TYPE GALAXIES: A CORRELATION BETWEEN STELLAR POPULATIONS AND ASYMMETRY  

Science Conference Proceedings (OSTI)

One of the key predictions of the merger hypothesis for the origin of early-type (elliptical and lenticular) galaxies is that tidally induced asymmetric structure should correlate with signatures of a relatively young stellar population. Such a signature was found by Schweizer and Seitzer at roughly 4{sigma} confidence. In this paper, we revisit this issue with a nearly ten-fold larger sample of 0.01 gas-rich major and minor mergers that reproduces their observed buildup from z = 1 to the present day and the distribution of present-day colors and ages. We show using this model that if both stellar populations and asymmetry were ideal 'clocks' measuring the time since last major or minor gas-rich interaction, then we would expect a rather tight correlation between age and asymmetry. We suggest that the source of extra scatter is natural diversity in progenitor star formation history, gas content, and merger mass ratio, but quantitative confirmation of this conjecture will require sophisticated modeling. We conclude that the asymmetry-age correlation is in basic accord with the merger hypothesis, and indicates that an important fraction of the early-type galaxy population is affected by major or minor mergers at cosmologically recent times.

Gyory, Zsuzsanna [Department of Physics, Eoetvoes University, Budapest, Pf. 32, H-1518 (Hungary); Bell, Eric F., E-mail: gyory.zsuzsa@googlemail.co, E-mail: ericbell@umich.ed [Max-Planck-Institut fuer Astronomie, Koenigstuhl 17, D-69117 Heidelberg (Germany)

2010-11-20T23:59:59.000Z

375

Minute Effects of Sex on the Aging Brain: A Multisample Magnetic Resonance Imaging Study of Healthy Aging and Alzheimer's Disease  

E-Print Network (OSTI)

Age is associated with substantial macrostructural brain changes. While some recent magnetic resonance imaging studies have reported larger age effects in men than women, others find no sex differences. As brain morphometry ...

Fjell, Anders M.

376

Aging Studies of Sr-doped LaCrO3/YSZ/Pt Cells for an Electrochemical NOx Sensor  

DOE Green Energy (OSTI)

The stability and NO{sub x} sensing performance of electrochemical cells of the structure Sr-doped LaCrO{sub 3-{delta}} (LSC)/yttria-stabilized zirconia (YSZ)/Pt are being investigated for use in NO{sub x} aftertreatment systems in diesel vehicles. Among the requirements for NO{sub x} sensor materials in these systems are stability and long lifetime (up to ten years) in the exhaust environment. In this study, cell aging effects were explored following extended exposure to a test environment of 10% O{sub 2} at operating temperatures of 600-700 C. The data show that aging results in changes in particle morphology, chemical composition and interfacial structure, Impedance spectroscopy indicated an initial increase in the cell resistance during the early stages of aging, which is correlated to densification of the Pt electrode. Also, x-ray photoelectron spectroscopy indicated formation of SrZrO{sub 2} solid state reaction product in the LSC, a process which is of finite duration. Subsequently, the overall cell resistance decreases with aging time due, in part, to roughening of YSZ-LSC interface, which improves interface adherence and enhances charge transfer kinetics at the O{sub 2}/YSZ/LSC triple phase boundary. This study constitutes a first step in the development of a basic understanding of aging phenomena in solid state electrochemical systems with application not only to sensors, but also to fuel cells, membranes, and electrolyzers.

Song, S; Martin, L P; Glass, R S; Murray, E P; Visser, J H; Soltis, R E; Novak, R F; Kubinski, D J

2005-10-05T23:59:59.000Z

377

Economic Impacts of Early Care and Education in California  

E-Print Network (OSTI)

Economic Impacts of Early Care and Education in California by Jenifer MacGillvary and Laurel Lucia August 2011 #12;#12;Economic Impacts of Early Care and Education in California by Jenifer MacGillvary and Laurel Lucia University of California, Berkeley Center for Labor Research and Education August 2011 #12

Militzer, Burkhard

378

Applying advanced simulation in early stage unconventional ship design  

Science Conference Proceedings (OSTI)

A detailed description of the first, or global, optimization stage of two-stage hydrodynamic optimization framework for high-speed vessels is presented. A key feature of the framework is the application of advanced simulation in the early phases of design ... Keywords: early-stage design, high-speed vessel, optimization, ship design, surrogate model

Matthew Collette; Woei-Min Lin; Jun Li

2010-07-01T23:59:59.000Z

379

Z' physics with early LHC data  

E-Print Network (OSTI)

We discuss the prospects for setting limits on or discovering spin-1 $Z'$ bosons using early LHC data at 7 TeV. Our results are based on the narrow width approximation in which the leptonic Drell-Yan $Z'$ boson production cross-section only depends on the $Z'$ boson mass together with two parameters $c_u$ and $c_d$. We carefully discuss the experimental cuts that should be applied and tabulate the theoretical next-to-next-to-leading order corrections which must be included. Using these results the approach then provides a safe, convenient and unbiased way of comparing experiment to theoretical models which avoids any built-in model dependent assumptions. We apply the method to three classes of perturbative $Z'$ boson benchmark models: $E_6$ models, left-right symmetric models and sequential standard models. We generalise each class of model in terms of {mixing angles which continuously parametrize} linear combinations of pairs of generators and lead to distinctive orbits in the $c_u-c_d$ plane. We also apply this method to the strongly coupled four-site benchmark model in which two $Z'$ bosons are predicted. By comparing the experimental limits or discovery bands to the theoretical predictions on the $c_u$-$c_d$ plane, we show that the LHC at 7 TeV with integrated luminosity of 500 pb$^{-1}$ will greatly improve on current Tevatron mass limits for the benchmark models. If a $Z'$ is discovered our results show that measurement of the mass and cross-section will provide a powerful discriminator between the benchmark models using this approach.

Elena Accomando; Alexander Belyaev; Luca Fedeli; Stephen F. King; Claire Shepherd-Themistocleous

2010-10-28T23:59:59.000Z

380

The Transuranium Elements: Early History (Nobel Lecture)  

DOE R&D Accomplishments (OSTI)

In this talk the author tells of the circumstances that led to the discovery of neptunium, the first element beyond uranium, and the partial identification of plutonium, the next one beyond that. The part of the story that lies before 1939 has already been recounted here in the Nobel lectures of Fermi and Hahn. Rather the author starts with the discovery of fission by Hahn and Strassmann. News of this momentous discovery reached Berkeley early in 1939. The staff of the Radiation Laboratory was put into a state of great excitement and several experiments of a nature designed to check and extend the announced results were started, using ionization chambers and pulse amplifiers, cloud chambers, chemical methods, and so forth. The author decided to do an experiment of a very simple kind. When a nucleus of uranium absorbs a neutron and fission takes place, the two resulting fragments fly apart with great violence, sufficient to propel them through air or other matter for some distance. This distance, called the "range", is quantity of some interest, and the author undertook to measure it by observing the depth of penetration of the fission fragments in a stack of thin aluminum foils. The fission fragments came from a thin layer of uranium oxide spread on a sheet of paper, and exposed to neutrons from a beryllium target bombarded by 8 Mev deuterons in the 37-inch cyclotron. The aluminum foils, each with a thickness of about half a milligram per square centimeter, were stacked like the pages of a book in immediate contact with the layer of uranium oxide. After exposure to the neutrons, the sheets of aluminum were separated and examined for radioactivity by means of an ionization chamber. The fission fragments of course are radioactive atoms, and their activity is found where they stop.

McMillan, E. M.

1951-12-12T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
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We encourage you to perform a real-time search of NLEBeta
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381

President Obama Named 13 Energy Department Scientists for Outstanding Early  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Named 13 Energy Department Scientists for Named 13 Energy Department Scientists for Outstanding Early Career Award President Obama Named 13 Energy Department Scientists for Outstanding Early Career Award July 26, 2012 - 11:12am Addthis President Obama today named 96 researchers as recipients of the Presidential Early Career Awards for Scientists and Engineers, the highest honor bestowed by the United States Government on science and engineering professionals in the early stages of their independent research careers. These include 13 receipients from the Energy Department. "Discoveries in science and technology not only strengthen our economy, they inspire us as a people." President Obama said. "The impressive accomplishments of today's awardees so early in their careers promise even greater advances in the years ahead."

382

Energy Department Early Career Scientists and Engineers Honored |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Early Career Scientists and Engineers Honored Early Career Scientists and Engineers Honored Energy Department Early Career Scientists and Engineers Honored November 1, 2007 - 4:21pm Addthis WASHINGTON, DC - At a White House ceremony today, eight "early career" researchers, funded by the U.S. Department of Energy's (DOE) Office of Science and its National Nuclear Security Administration (NNSA), were honored for their work ranging from computer vision and machine intelligence to identifying genetic switches in the human genome. DOE's scientists are among 58 researchers supported by nine federal departments and agencies who received the Presidential Early Career Award for Scientists and Engineers. The Presidential award is the highest honor bestowed by the U.S. government on outstanding scientists and engineers who

383

Energy Department Scientists and Engineers Honored with Presidential Early  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Energy Department Scientists and Engineers Honored with Energy Department Scientists and Engineers Honored with Presidential Early Career Awards Energy Department Scientists and Engineers Honored with Presidential Early Career Awards December 19, 2008 - 9:16am Addthis WASHINGTON, DC - At a White House ceremony today, eight "early career" researchers, funded by the U.S. Department of Energy's (DOE) Office of Science and the National Nuclear Security Administration (NNSA), were honored with the Presidential Early Career Award for Scientists and Engineers (PECASE)-the highest honor bestowed by the U.S. government on outstanding scientists and engineers who are early in their independent research careers. The DOE awardees were recognized for their research efforts in a variety of issues, from computational biology to atomic,

384

Secretary Chu Announces 68 Scientists to Receive Early Career Research  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

68 Scientists to Receive Early Career 68 Scientists to Receive Early Career Research Program Funding Secretary Chu Announces 68 Scientists to Receive Early Career Research Program Funding May 18, 2012 - 3:05pm Addthis News Media Contact (202) 386-4940 WASHINGTON - Underscoring the Obama Administration's commitment to investing in innovation and the American workforce, U.S. Department of Energy Secretary Steven Chu today announced that 68 scientists from across the nation will receive up to $18.9 million in funding for research grants as part of DOE's Early Career Research Program. The effort, now in its third year, is designed to bolster the nation's scientific workforce by providing support to exceptional researchers during the crucial early career years, when many scientists do their most formative work.

385

Energy Department Announces 61 Scientists to Receive Early Career Research  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

61 Scientists to Receive Early Career 61 Scientists to Receive Early Career Research Program Funding Energy Department Announces 61 Scientists to Receive Early Career Research Program Funding May 7, 2013 - 12:56pm Addthis NEWS MEDIA CONTACT (202) 586-4940 WASHINGTON - Underscoring the Obama Administration's commitment to investing in innovation and the American workforce, Acting Secretary of Energy Daniel Poneman today announced that 61 scientists from across the nation will receive up to $15.3 million in funding for research as part of the Energy Department's Early Career Research Program. The effort, now in its fourth year, is designed to bolster the nation's scientific workforce by providing support to exceptional researchers during the crucial early career years, when many scientists do their most formative

386

Extruded Dielectrics for Transmission Cables: Evaluation of Aging Models  

Science Conference Proceedings (OSTI)

One of the tasks proposed at the 2002 EPRI workshop on the aging of extruded transmission cables was to evaluate three recently developed theoretical aging models of electrical insulation. The three models were (1) the Thermodynamic Model of Aging of Extruded Insulation by J.P. Crine; (2) the Space Charge Aging Model by L.A. Dissado, G. Mazzanti, and G.C. Montanari (DMM); and (3) the Electromechanical Aging Model by T.J. Lewis. These three models are considered to be significant improvements over the emp...

2003-12-31T23:59:59.000Z

387

The Sandia MEMS Passive Shock Sensor : dormancy and aging.  

SciTech Connect

This report presents the results of an aging experiment that was established in FY09 and completed in FY10 for the Sandia MEMS Passive Shock Sensor. A total of 37 packages were aged at different temperatures and times, and were then tested after aging to determine functionality. Aging temperatures were selected at 100 C and 150 C, with times ranging from as short as 100 hours to as long as 1 year to simulate a predicted aging of up to 20 years. In all of the tests and controls, 100% of the devices continued to function normally.

Baker, Michael Sean; Tanner, Danelle Mary

2010-12-01T23:59:59.000Z

388

The bronze age shipwreck at Sheytan Deresi  

E-Print Network (OSTI)

During the fall of 1973, the newly formed (American) Institute of Nautical Archaeology conducted its first systematic underwater survey of the southwestern coast of Turkey with the goal of locating the first shipwreck to be subsequently excavated by the Institute. Of the 18 wreck sites identified during the survey, a site off Sheytan Deresi (Devil’s Creek) proved to be the one that attracted George Bass, director of the survey, as most meriting further study. During the excavation that followed in September and October 1975, the site produced a number of complete and fragmentary ceramic vessels that formed the main artifact assemblage. Although the ceramic vessels brought to light at Sheytan Deresi have been studied by George Bass, Roxani Margariti and others since the 1975 excavation, locating precise parallels for the assemblage proved a difficult task and resulted in a less than full understanding of the site. The following thesis represents a renewed effort to answer a number of questions still surrounding the Sheytan Deresi site. In addition to expanding the extensive search for parallels undertaken by Bass and Margariti, recent research has involved a number of scientific analyses, including petrographic analysis of the ceramic assemblage, luminescence dating of ceramic fragments, and elemental examination of the fabric through neutron activation analysis and energy dispersive spectroscopy. The use of three-dimensional modeling has been adopted for the purposes of site interpretation. Although the impact of this more holistic approach cannot be entirely foreseen at this time, a number of interesting hypotheses regarding the site can now be suggested. It appears that the ceramic assemblage, which is now conclusively of a single origin, may be of a specialized maritime nature, and likely belongs to the Middle Bronze Age, reminiscent of, but entirely similar to, regional types of Anatolian and Cretan vessels. These tentative conclusions, as well as an examination of the site itself, suggest that the (Minoanizing) ceramic assemblage of Sheytan Deresi stood witness to a fairly small Middle Bronze Age coastal trading vessel that capsized rounding a dangerous cape, not far from its point of origin. We are still not in a position to fully comprehend the wrecking event that took place at Sheytan Deresi, but we are now firmly on course towards reaching that objective.

Catsambis, Alexis

2008-05-01T23:59:59.000Z

389

Those early days as we remember them (part V) - Met Lab and Argonne's Early  

NLE Websites -- All DOE Office Websites (Extended Search)

V) V) About Director's Welcome Organization Achievements Highlights Fact Sheets, Brochures & Other Documents Multimedia Library Visit Argonne Work with Argonne Contact us Nuclear Energy Why Nuclear Energy? Why are some people afraid of Nuclear Energy? How do nuclear reactors work? Cheaper & Safer Nuclear Energy Helping to Solve the Nuclear Waste Problem Nuclear Reactors Nuclear Reactors Early Exploration Training Reactors Basic and Applied Science Research LWR Technology Development BORAX-III lighting Arco, Idaho (Press Release) Heavy Water and Graphite Reactors Fast Reactor Technology Integral Fast Reactor Argonne Reactor Tree CP-1 70th Anniversary CP-1 70th Anniversary Argonne's Nuclear Science and Technology Legacy Argonne's Nuclear Science and Technology Legacy Promethean Boldness

390

Those early days as we remember them (Part I) - Met Lab & Early Argonne History  

NLE Websites -- All DOE Office Websites (Extended Search)

4 4 Those early days as we remember them Austin M. Brues Biological and Medical Research Division I would like to start my story a few months before I joined the Metallurgical Laboratory in the fall of 1944. I was engaged in some wartime research on battlefield shock, and was involved in some therapy and research with P 32 ; in the course of which I was accustomed to carrying tubes of it between M.I.T. and my laboratory in a shirt pocket.

391

Aging and weathering of cool roofing membranes  

Science Conference Proceedings (OSTI)

Aging and weathering can reduce the solar reflectance of cool roofing materials. This paper summarizes laboratory measurements of the solar spectral reflectance of unweathered, weathered, and cleaned samples collected from single-ply roofing membranes at various sites across the United States. Fifteen samples were examined in each of the following six conditions: unweathered; weathered; weathered and brushed; weathered, brushed and then rinsed with water; weathered, brushed, rinsed with water, and then washed with soap and water; and weathered, brushed, rinsed with water, washed with soap and water, and then washed with an algaecide. Another 25 samples from 25 roofs across the United States and Canada were measured in their unweathered state, weathered, and weathered and wiped. We document reduction in reflectivity resulted from various soiling mechanisms and provide data on the effectiveness of various cleaning approaches. Results indicate that although the majority of samples after being washed with detergent could be brought to within 90% of their unweathered reflectivity, in some instances an algaecide was required to restore this level of reflectivity.

Akbari, Hashem; Berhe, Asmeret A.; Levinson, Ronnen; Graveline,Stanley; Foley, Kevin; Delgado, Ana H.; Paroli, Ralph M.

2005-08-23T23:59:59.000Z

392

Weldable, age hardenable, austenitic stainless steel  

DOE Patents (OSTI)

An age hardenable, austenitic stainless steel having superior weldability properties as well as resistance to degradation of properties in a hydrogen atmosphere is described. It has a composition of from about 24.0 to about 34.0 weight percent (w/o) nickel, from about 13.5 to about 16.0 w/o chromium, from about 1.9 to about 2.3 w/o titanium, from about 1.0 to about 1.5 w/ o molybdenum, from about 0.01 to about 0.05 w/o carbon, from about 0 to about 0.25 w/o manganese, from about 0 to about 0.01 w/o phosphorous and preferably about 0.005 w/o maximum, from about 0 to about 0.010 w/o sulfur and preferably about 0.005 w/o maximum, from about 0 to about 0.25 w/o silicon, from about 0.1 to about 0.35 w/o aluminum, from about 0.10 to about 0.50 w/o vanadium, from about 0 to about 0.0015 w/o boron, and the balance essentially iron. (auth)

Brooks, J.A.; Krenzer, R.W.

1975-07-22T23:59:59.000Z

393

Early Market TRL/MRL Analysis  

SciTech Connect

he focus of this report is TRL/MRL analysis of hydrogen storage; it documents the methodology and results of an effort to identify hydrogen storage technologies’ technical and manufacturing readiness for early market motive and non-motive applications and to provide a path forward toward commercialization. Motive applications include materials handling equipment (MHE) and ground support equipment (GSE), such as forklifts, tow tractors, and specialty vehicles such as golf carts, lawn mowers and wheel chairs. Non-motive applications are portable, stationary or auxiliary power units (APUs) and include portable laptops, backup power, remote sensor power, and auxiliary power for recreational vehicles, hotels, hospitals, etc. Hydrogen storage technologies assessed include metal hydrides, chemical hydrides, sorbents, gaseous storage, and liquid storage. The assessments are based on a combination of Technology Readiness Level (TRL) and Manufacturing Readiness Level (MRL) designations that enable evaluation of hydrogen storage technologies at varying levels of development. The manufacturing status could be established from eight risk elements: Technical Maturity, Design, Materials, Cost & Funding, Process Capability, Personnel, Facilities and Manufacturing Planning. This approach provides a logical methodology and roadmap to enable the identification of hydrogen storage technologies, their advantages/disadvantages, gaps and R&D needs on an unbiased and transparent scale that is easily communicated to interagency partners. This technology readiness assessment (TRA) report documents the process used to conduct the TRA/MRA (technology and manufacturing readiness assessment), reports the TRL and MRL for each assessed technology and provides recommendations based on the findings. To investigate the state of the art and needs to mature the technologies, PNNL prepared a questionnaire to assign TRL and MRL for each hydrogen storage technology. The questionnaire was sent to identified hydrogen storage technology developers and manufacturers who were asked to perform a self-assessment. We included both domestic and international organizations including U.S. national laboratories, U.S. companies, European companies and Japanese companies. PNNL collected the data and performed an analysis to deduce the level of maturity and to provide program recommendations.

Ronnebro, Ewa; Stetson, Ned

2013-12-01T23:59:59.000Z

394

Early Exploration - Reactors designed/built by Argonne National Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Early Exploration Early Exploration About Director's Welcome Organization Achievements Highlights Fact Sheets, Brochures & Other Documents Multimedia Library Visit Argonne Work with Argonne Contact us Nuclear Energy Why Nuclear Energy? Why are some people afraid of Nuclear Energy? How do nuclear reactors work? Cheaper & Safer Nuclear Energy Helping to Solve the Nuclear Waste Problem Nuclear Reactors Nuclear Reactors Early Exploration Training Reactors Basic and Applied Science Research LWR Technology Development BORAX-III lighting Arco, Idaho (Press Release) Heavy Water and Graphite Reactors Fast Reactor Technology Integral Fast Reactor Argonne Reactor Tree CP-1 70th Anniversary CP-1 70th Anniversary Argonne's Nuclear Science and Technology Legacy Argonne's Nuclear Science and Technology Legacy

395

Memorandum of Understanding on early coordination of federal authorizations  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

on early coordination of federal on early coordination of federal authorizations and related environmental reviews required in order to site electric transmission facilities: August 2006 Memorandum of Understanding on early coordination of federal authorizations and related environmental reviews required in order to site electric transmission facilities: August 2006 With the signing of this Memorandum of Understanding (MOU), the Department of Energy (DOE), the Department of Agriculture (USDA), the Department of Defense (DOD), the Department of the Interior POI), the Department of Commerce (DOC), the Federal Energy Regulatory Commission (FERC), the Environmental Protection Agency (EPA), the Council on Environmental Quality (CEQ), and the Advisory Council on Historic Preservation (ACHP)

396

DOE Science Showcase - "PECASE: Outstanding early career research  

Office of Scientific and Technical Information (OSTI)

"PECASE: Outstanding early career research "PECASE: Outstanding early career research honored" Energy Department Scientists & Engineers Honored with Presidential Early Career Awards PECASE award ceremony DOE recently recognized the following scientists and engineers at the outset of their independent research careers: Dillon Fong and Elena V. Shevchenko of Argonne National Laboratory Find Dillon Fong's research in the Energy Citations Database Find Elena Shevchenko's research with the Energy Citations Database Gavin E. Crooks and Trent R. Northen of Lawrence Berkeley National Laboratory Find Gavin Crooks research with the Science Accelerator Find Trent Northen's research with the Science Accelerator Jacob M. Hookerof Brookhaven National Laboratory Find Jacob Hooker's research in the Energy Citations Database

397

Tracking Changes in Early Paleoindian Technology and Adaptations on the Southern Plains Periphery  

E-Print Network (OSTI)

This dissertation presents new data on early Paleoindian stone technologies in the Southern Plains periphery. Analyses of lithic artifact assemblages show that significant technological changes occurred between the transitions from pre-Clovis to Clovis and from Clovis to Folsom/Midland. After an initial introduction to the problems in chapter one, a detailed technological description of the pre-Clovis assemblage from the Debra L. Friedkin site, Texas is presented. Site-scale and general technological comparisons to Clovis reveal similarities and differences. I conclude that the pre-Clovis assemblage at Friedkin cannot be considered Clovis, but could represent an ancestral technological assemblage. The third chapter presents the analysis of Clovis bifaces from the Hogeye site, Texas. I identify patterns in the biface reduction process and suggest that these patterns could be use to distinguish between regional Clovis cultural signatures and the idiosyncrasies of individual Clovis flintknappers. The fourth chapter compares Clovis and Folsom/Midland technologies and site-use at a single site, the Debra L. Friedkin site, Texas. I show that while late-stage biface reduction and point production were the focus of both occupations, Folsom/Midland groups also reduced some early- or middle- stage bifacial cores. More broadly, the Friedkin site shows that Clovis and Folsom/Midland settlement along Buttermilk Creek varied. Ultimately, this dissertation provides new evidence of possible Clovis origins, documents Clovis biface reduction signatures, and identifies site-use and technological similarities and differences between Clovis and Folsom/Midland. Defining and comparing early Paleoindian adaptations and technologies is key to understanding how humans dispersed into North America and how they adapted to new and changing environments during the last Ice Age.

Jennings, Thomas

2012-05-01T23:59:59.000Z

398

Free Energy Component Analysis for Drug Design: A Case Study of HIV-1 Protease-Inhibitor Binding  

E-Print Network (OSTI)

Free Energy Component Analysis for Drug Design: A Case Study of HIV-1 Protease-Inhibitor Binding of the free energies of binding of protein-ligand complexes is presented. The method formulated involves developing molecular dynamics trajectories of the enzyme, the inhibitor, and the complex, followed by a free

Jayaram, Bhyravabotla

399

Molecular dynamics simulations and docking of non-nucleoside reverse transcriptase inhibitors (NNRTIs): a possible approach to personalized HIV treatment  

E-Print Network (OSTI)

, Germany. Published: 1 May 2012 References 1. WHO: The top 10 causes of death.. 2. Chen LF, Hoy J, Lewin SR: Ten years of highly active antiretroviral therapy for HIV infection. Med J Australia 2007, 186:146-151. 3. Turner BG, Summers MF: Structural biology...

2012-05-01T23:59:59.000Z

400

Cast Stainless Steel Aging Research Plan | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Cast Stainless Steel Aging Research Plan Cast Stainless Steel Aging Research Plan Cast Stainless Steel Aging Research Plan This work plan proposes to build a systematic knowledge base for the thermal aging behavior of cast stainless steels (CASSs) within a limited time of five years. The final output of execution of the plan is expected to provide conclusive predictions for the integrity of the CASS components of LWR power plants during the extended service life up to and beyond 60 years. Mechanical and microstructural data obtained through accelerated aging experiment and computational simulation will be the key input for the prediction of CASS behaviors and for the integrity analyses for various CASS components. While the accelerated aging experiment and computational simulation results will comprise the main components of the knowledge base

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

Crystal Structure of the Hexameric Assembly Unit of the HIV Capsid  

NLE Websites -- All DOE Office Websites (Extended Search)

Crystal Structure of the Hexameric Assembly Unit of the Crystal Structure of the Hexameric Assembly Unit of the HIV Capsid The ribonucleoprotein genomic complex of human immunodeficiency virus type 1 (HIV-1) is encased within the mature capsid, a predominantly cone-shaped shell assembled from ~1,500 copies of the viral CA protein [1]. Packaging of the viral genome and its associated enzymes into the capsid is required for their delivery into host cells. To form a closed shell the CA protein assembles into ~250 hexamers. The CA hexamer consists of a ring of six N-terminal domains around a central core, surrounded by an outer ring of six more mobile C-terminal domains. Based on crystal structures of the individual domains, and electron microscopy (EM) data of assembled hexamers, the C-terminal domains are in contact with neighboring N-terminal domains by rotation of 60° about the hexamer 6-fold axis. Flexibility between these domains allows the CA hexamer to subtly adapt its shaped within the curved array of the assembled capsid.

402

Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications  

Science Conference Proceedings (OSTI)

Advanced glycation or glycoxidation end-products (AGE) increase in tissue proteins with age, and their rate of accumulation is increased in diabetes, nephropathy and inflammatory diseases. AGE inhibitors include a range of compounds that are proposed to act by trapping carbonyl and dicarbonyl intermediates in AGE formation. However, some among the newer generation of AGE inhibitors lack reactive functional groups that would trap reaction intermediates, indicating an alternative mechanism of action. We propose that AGE inhibitors function primarily as chelators, inhibiting metal-catalyzed oxidation reactions. The AGE-inhibitory activity of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers is also consistent with their chelating activity. Finally, compounds described as AGE breakers, or their hydrolysis products, also have strong chelating activity, suggesting that these compounds also act through their chelating activity. We conclude that chelation is the common, and perhaps the primary, mechanism of action of AGE inhibitors and breakers, and that chronic, mild chelation therapy should prove useful in treatment of diabetes and age-related diseases characterized by oxidative stress, inflammation and increased chemical modification of tissue proteins by advanced glycoxidation and lipoxidation end-products.

Nagai, Rhoji; Murray, David B.; Metz, Thomas O.; Baynes, John

2012-03-01T23:59:59.000Z

403

In search of information on websites: a question of age?  

Science Conference Proceedings (OSTI)

To fight against info-exclusion in an aging society, it is important to make website information available to all generations. If we want to achieve this goal we need to know the impact of not only age but also gender, educational background and frequency ... Keywords: age differences, digital immigrants, digital natives, digital spectrum, digitalgap, eye-tracking, information search behaviour, navigation patterns, usability, web design

Eugčne Loos

2011-07-01T23:59:59.000Z

404

Aging, Fragility and Reversibility Window in Bulk Alloy Glasses  

E-Print Network (OSTI)

Non-reversing relaxation enthalpies (DHnr) at glass transitions Tg(x) in the PxGexSe1-2x ternary display wide, sharp and deep global minima (~ 0) in the 0.09 age, in contrast to aging observed for fragile glass compositions outside the window. Thermal reversibility and lack of aging seem to be paradigms of self-organization which molecular glasses share with protein structures which repetitively and reversibly change conformation near Tg and the folding temperature respectively.

S. Chakravarty; D. G. Georgiev; P. Boolchand; M. Micoulaut

2007-09-27T23:59:59.000Z

405

Solid-State Lighting Issue 12: Scientific Literature (Early February -  

NLE Websites -- All DOE Office Websites (Extended Search)

2: SCIENTIFIC LITERATURE (Early February - Early April 2002) 2: SCIENTIFIC LITERATURE (Early February - Early April 2002) From the Technical Literature The material in this section is selected from scientific and technical papers that became available during the reporting time period. Links to online abstracts are provided. Most online abstracts are freely accessible to the public. A few require journal subscriptions or memberships, and are noted as such. The technical literature section is roughly organized by subject area and, within subjects, alphabetically by institution of the lead author. Use the links below to go directly to a section. A. Materials and Device Fabrication B. Materials and Device Design Properties C. Packaging and Reliability D. Lighting Systems A. Materials and Device Fabrication

406

LANL, LLNL researchers among Early Career Research Program award recipients  

National Nuclear Security Administration (NNSA)

LANL, LLNL researchers among Early Career Research Program award recipients LANL, LLNL researchers among Early Career Research Program award recipients | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > LANL, LLNL researchers among Early Career Research ... LANL, LLNL researchers among Early Career Research Program award recipients Posted By Office of Public Affairs

407

EIA-Annual Energy Outlook 2008 (Early Release)  

Gasoline and Diesel Fuel Update (EIA)

with Projections to 2030 with Projections to 2030 Annual Energy Outlook 2008 (Early Release) The early release version of the AEO2008 reference case does not include consideration of the H.R.6, "Energy Independence and Security Act of 2007," that was signed into law on December 19, 2007. EIA is compiling a revised reference case that includes the impact of H.R.6. The Annual Energy Outlook presents a midterm projection and analysis of US energy supply, demand, and prices through 2030. The projections are based on results from the Energy Information Administration's National Energy Modeling System. The AEO2008 Early Release includes the reference case. The full publication, to be released in early 2008, will include complete documentation and additional cases examining energy markets.

408

Early Canadian Weather Observers and the “Year Without a Summer”  

Science Conference Proceedings (OSTI)

The unusual spring and summer weather of the year 1816 in central Canada is discussed using Canadian newspaper accounts together with manuscript records from early amateur weather observers. Many of the spectacular meteorological events of this ...

Kevin Hamilton

1986-05-01T23:59:59.000Z

409

Meteorite made up of rare early solar system material  

NLE Websites -- All DOE Office Websites (Extended Search)

1613meteorite 01162013 Meteorite made up of rare early solar system material Anne M Stark, LLNL, (925) 422-9799, stark8@llnl.gov Printer-friendly Pieces of the Sutter's Mill...

410

Energy Department Scientists and Engineers Honored with Presidential Early  

Office of Science (SC) Website

Energy Energy Department Scientists and Engineers Honored with Presidential Early Career Awards News Featured Articles Science Headlines 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Presentations & Testimony News Archives Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 P: (202) 586-5430 12.19.08 Energy Department Scientists and Engineers Honored with Presidential Early Career Awards Print Text Size: A A A Subscribe FeedbackShare Page WASHINGTON, DC - At a White House ceremony today, eight "early career" researchers, funded by the U.S. Department of Energy's (DOE) Office of Science and the National Nuclear Security Administration (NNSA), were honored with the Presidential Early Career Award for Scientists and

411

Celebrating Achievement and Potential at the Presidential Early Career  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Achievement and Potential at the Presidential Early Achievement and Potential at the Presidential Early Career Awards for Scientists and Engineers Celebrating Achievement and Potential at the Presidential Early Career Awards for Scientists and Engineers October 20, 2011 - 10:14am Addthis President Barack Obama greets the 2010 PECASE recipients in the East Room of the White House, Oct. 14, 2011. | Courtesy of the White House Photo Office President Barack Obama greets the 2010 PECASE recipients in the East Room of the White House, Oct. 14, 2011. | Courtesy of the White House Photo Office Charles Rousseaux Charles Rousseaux Senior Writer, Office of Science What is PECASE? The prestigious Presidential Early Career Awards for Scientists and Engineers (PECASE) recognize individuals who show exceptional potential for

412

Sandia National Laboratories' Stanley Atcitty Wins Presidential Early  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

National Laboratories' Stanley Atcitty Wins Presidential National Laboratories' Stanley Atcitty Wins Presidential Early Career Award for Scientists and Engineers Sandia National Laboratories' Stanley Atcitty Wins Presidential Early Career Award for Scientists and Engineers July 24, 2012 - 11:27am Addthis Dr. Stanley Atcitty, an energy storage systems researcher at Sandia National Laboratories, has been named a winner of the Presidential Early Career Award for Scientists and Engineers (PECASE). President Obama named 13 U.S. Department of Energy-funded researchers as recipients of the award which is the highest honor bestowed by the U.S. government on outstanding scientists and engineers, who are early in their independent research careers. Dr. Atcitty was nominated by the Office of Electricity Delivery and Energy

413

President Obama honors outstanding early-career scientists | National  

National Nuclear Security Administration (NNSA)

honors outstanding early-career scientists | National honors outstanding early-career scientists | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > President Obama honors outstanding early-career scientists President Obama honors outstanding early-career scientists Posted By Office of Public Affairs Five individuals from NNSA's national laboratories have been named

414

Early science runs prepare Sequoia for national security missions |  

National Nuclear Security Administration (NNSA)

Early science runs prepare Sequoia for national security missions | Early science runs prepare Sequoia for national security missions | National Nuclear Security Administration Our Mission Managing the Stockpile Preventing Proliferation Powering the Nuclear Navy Emergency Response Recapitalizing Our Infrastructure Continuing Management Reform Countering Nuclear Terrorism About Us Our Programs Our History Who We Are Our Leadership Our Locations Budget Our Operations Media Room Congressional Testimony Fact Sheets Newsletters Press Releases Speeches Events Social Media Video Gallery Photo Gallery NNSA Archive Federal Employment Apply for Our Jobs Our Jobs Working at NNSA Blog Home > NNSA Blog > Early science runs prepare Sequoia for national ... Early science runs prepare Sequoia for national security missions Posted By Office of Public Affairs

415

Early Results from Green Energy Match, An Innovative Behavior...  

NLE Websites -- All DOE Office Websites (Extended Search)

Early Results from Green Energy Match, An Innovative Behavior-Based Energy Savings Program for San Jose Residents Speaker(s): Martha Amram Shayna Hirschfield Date: July 26, 2012 -...

416

Jewish Social History in the Nineteenth And Early Twentieth Centuries  

E-Print Network (OSTI)

fundamental ambivalence of success in modern Jewish history.its Limits. Jewish Social History in the 19th and Early 20thof trend-setting works on the history of the Jews and anti-

Rürup, Reinhard

2004-01-01T23:59:59.000Z

417

Lab's early submarine reactor program paved the way for modern...  

NLE Websites -- All DOE Office Websites (Extended Search)

nuclear power plants. Atomic submarine Nautilus EARLY TRIUMPH - Conceptual design of the power plant of the U.S.S. Nautilus, the world's first nuclear-powered ship, was performed...

418

Data Analysis of Early Fuel Cell Market Demonstrations (Presentation)  

SciTech Connect

Presentation about early fuel cell markets, the National Renewable Energy Laboratory's Hydrogen Secure Data Center and its role in data analysis and demonstrations, and composite data products, and results reported to multiple stakeholders.

Kurtz, J.; Ramsden, T.; Wipke, K.; Sprik, S.

2009-11-17T23:59:59.000Z

419

Data Analysis for ARRA Early Fuel Cell Market Demonstrations (Presentation)  

SciTech Connect

Presentation about ARRA Early Fuel Cell Market Demonstrations, including an overview of the ARRE Fuel Cell Project, the National Renewable Energy Laboratory's data analysis objectives, deployment composite data products, and planned analyses.

Kurtz, J.; Wipke, K.; Sprik, S.; Ramsden, T.

2010-05-01T23:59:59.000Z

420

Commissioning and early experiments of the PHELIX facility  

E-Print Network (OSTI)

009-3855-7 Commissioning and early experiments of the PHELIXthe recent years, the commissioning and operation of high-paper, we report on the commissioning of the PHELIX facility

2010-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


421

Early Days of Coal Research | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Days of Coal Research Early Days of Coal Research Wartime Needs Spur Interest in Coal-to-Oil Processes In 1944 General George S. Patton's Third Army was racing across southern...

422

Laboratory scientists win three Office of Science Early Career...  

NLE Websites -- All DOE Office Websites (Extended Search)

5-03 For immediate release: 05112011 | NR-11-05-03 Laboratory scientists win three Office of Science Early Career Research Program awards Anne M Stark, LLNL, (925) 422-9799,...

423

The early planning and development of Oklahoma City  

E-Print Network (OSTI)

An analysis of the planning, development, and implementation of Oklahoma City's Grand Boulevard. In the early days of 1909, a plan emerged to build an expansive parks and boulevard system to encircle Oklahoma City. Such ...

Humphreys, Blair D. (Blair David)

2009-01-01T23:59:59.000Z

424

First look at cellulose's early production could hold keys to...  

NLE Websites -- All DOE Office Websites (Extended Search)

cellulose's early production could hold keys to bacteria-free medical devices, better biofuel By Jared Sagoff * May 14, 2013 Tweet EmailPrint Produced by plants as well as algae...

425

LatticeQCD - Early Science | Argonne Leadership Computing Facility  

NLE Websites -- All DOE Office Websites (Extended Search)

summary of Lattice QCD averages The current summary of Lattice QCD averages. Laiho, Lunghi, & Van de Water, Phys.Rev.D81:034503,2010. LatticeQCD - Early Science PI Name: Paul...

426

Diamond: a storage architecture for early discard in interactive search  

Science Conference Proceedings (OSTI)

This paper explores the concept of early discard for interactive search of unindexed data. Processing data inside storage devices using downloaded searchlet code enables Diamond to perform efficient, applicationspecific filtering of large data collections. ...

Larry Huston; Rahul Sukthankar; Rajiv Wickremesinghe; M. Satyanarayanan; Gregory R. Ganger; Erik Riedel; Anastassia Ailamaki

2004-03-01T23:59:59.000Z

427

Data Analysis of Early Fuel Cell Market Demonstrations (Presentation)  

DOE Green Energy (OSTI)

Presentation about early fuel cell markets, the National Renewable Energy Laboratory's Hydrogen Secure Data Center and its role in data analysis and demonstrations, and composite data products, and results reported to multiple stakeholders.

Kurtz, J.; Ramsden, T.; Wipke, K.; Sprik, S.

2009-11-17T23:59:59.000Z

428

Designing CPV Receivers With Reliability: Early Evaluation of Components  

E-Print Network (OSTI)

Designing CPV Receivers With Reliability: Early Evaluation of Components Objective Materials from power electronics industry must be proven when integrated in PV applications. Pre-qualification tests improves the receiver design and reliability. ANU microconcentrator test&design experience

429

LLNL'S Yuan Ping receives DOE Early Career Research Program Award  

NLE Websites -- All DOE Office Websites (Extended Search)

LLNL'S Yuan Ping receives DOE Early Career Research Program Award Breanna Bishop, LLNL, (925) 423-9802, bishop33@llnl.gov Printer-friendly Yuan Ping stands next to the target...

430

A Review of Equipment Aging Theory and Technology  

Science Conference Proceedings (OSTI)

Reviews the theory and technology of equipment aging particularly as they relate to the qualification of safety-system equipment for nuclear power generating stations.

1980-09-01T23:59:59.000Z

431

PROPOSAL Characterization of Field and Lab Aged Cables  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DoE Peer Review Nov 2010 2 * Underground cable system infrastructure is complex and aging. * Failures are increasing * If not addressed then old infrastructure will not support...

432

Precipitates in Long Term Aging Al 5083 Alloy  

Science Conference Proceedings (OSTI)

Presentation Title, Precipitates in Long Term Aging Al 5083 Alloy. Author(s), Gaosong Yi. On-Site Speaker (Planned), Gaosong Yi. Abstract Scope, Al 5083 alloy ...

433

Two-Sensor System for Absolute Age and Temperature History  

absolute age and/or temperature history of a device or system starting from the time it is assembled or commissioned. Ideally this information could ...

434

Effects of Aging Parameters on the Mechanical Properties in Corson ...  

Science Conference Proceedings (OSTI)

In the present study, the influences of solution treatments, prior cold drawings and aging treatments on mechanical properties in Corson alloy with high ...

435

Signatures of Dynamic Strain Aging – The Mechanical Threshold ...  

Science Conference Proceedings (OSTI)

At elevated temperatures, but even at temperatures well below one-half the melting point, dynamic strain aging (DSA) can influence the stress-strain curve in

436

TIP Project Brief 090060 Robotic Rehabilitation of Aging ...  

Science Conference Proceedings (OSTI)

... most of which, unfortunately, are aging and in ... reinforced polymers for civil infrastructure rehabilitation; the ... the East Bay Municipal Utility District; the ...

2011-11-07T23:59:59.000Z

437

Plant Engineering: Cable Aging Management Program Implementation Guidance  

Science Conference Proceedings (OSTI)

This report describes issues identified during the initial implementation of low- and medium-voltage cable aging management programs by utilities and presents possible resolutions and guidance.

2011-12-01T23:59:59.000Z

438

Cosmic age problem revisited in the holographic dark energy model  

E-Print Network (OSTI)

Because of an old quasar APM 08279 + 5255 at $z=3.91$, some dark energy models face the challenge of the cosmic age problem. It has been shown by Wei and Zhang [Phys. Rev. D {\\bf 76}, 063003 (2007)] that the holographic dark energy model is also troubled with such a cosmic age problem. In order to accommodate this old quasar and solve the age problem, we propose in this paper to consider the interacting holographic dark energy in a non-flat universe. We show that the cosmic age problem can be eliminated when the interaction and spatial curvature are both involved in the holographic dark energy model.

Cui, Jinglei

2010-01-01T23:59:59.000Z

439

Age Inversiones in Media Ambiente AIMA | Open Energy Information  

Open Energy Info (EERE)

Product Invests in projects that aim to generate energy from biodegradable residues and waste. References Age Inversiones in Media Ambiente (AIMA)1 LinkedIn Connections...

440

CMS experiment at the LHC: Commissioning and early physics  

E-Print Network (OSTI)

The CMS collaboration used the past year to greatly improve the level of detector readiness for the first collisions data. The acquired operational experience over this year, large gains in understanding the detector and improved preparedness for early physics will be instrumental in minimizing the time from the first collisions to first LHC physics. The following describes the status of the CMS experiment and outlines early physics plans with the first LHC data.

A. Safonov

2010-03-21T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors  

Science Conference Proceedings (OSTI)

The small molecule CCR5 inhibitors are a new class of drugs for treating infection by human immunodeficiency virus type 1 (HIV-1). They act by binding to the CCR5 co-receptor and preventing its use during HIV-1-cell fusion. Escape mutants can be raised against CCR5 inhibitors in vitro and will arise when these drugs are used clinically. Here, we have assessed the responses of CCR5 inhibitor-resistant viruses to other anti-retroviral drugs that act by different mechanisms, and their sensitivities to neutralizing antibodies (NAbs). The rationale for the latter study is that the resistance pathway for CCR5 inhibitors involves changes in the HIV-1 envelope glycoproteins (Env), which are also targets for NAbs. The escape mutants CC101.19 and D1/85.16 were selected for resistance to AD101 and vicriviroc (VVC), respectively, from the primary R5 HIV-1 isolate CC1/85. Each escape mutant was cross-resistant to other small molecule CCR5 inhibitors (aplaviroc, maraviroc, VVC, AD101 and CMPD 167), but sensitive to protein ligands of CCR5: the modified chemokine PSC-RANTES and the humanized MAb PRO-140. The resistant viruses also retained wild-type sensitivity to the nucleoside reverse transcriptase inhibitor (RTI) zidovudine, the non-nucleoside RTI nevirapine, the protease inhibitor atazanavir and other attachment and fusion inhibitors that act independently of CCR5 (BMS-806, PRO-542 and enfuvirtide). Of note is that the escape mutants were more sensitive than the parental CC1/85 isolate to a subset of neutralizing monoclonal antibodies and to some sera from HIV-1-infected people, implying that sequence changes in Env that confer resistance to CCR5 inhibitors can increase the accessibility of some NAb epitopes. The need to preserve NAb resistance may therefore be a constraint upon how escape from CCR5 inhibitors occurs in vivo.

Pugach, Pavel; Ketas, Thomas J.; Michael, Elizabeth [Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065 (United States); Moore, John P. [Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065 (United States)], E-mail: jpm2003@med.cornell.edu

2008-08-01T23:59:59.000Z

442

Aging, Generations, and the Development of Partisan Polarization in the United States  

E-Print Network (OSTI)

Alwin, Duane F. 1994. "Aging, Personality, and SocialDuane F. Alwin. 1989. "Aging and Susceptibility to AttitudeAging, Generations, and the Development of Partisan

Stoker, Laura; Jennings, M. Kent

2006-01-01T23:59:59.000Z

443

Aging Impacts Transcriptome but not Genome of Hormone-dependent Breast Cancers  

E-Print Network (OSTI)

biological basis linking aging with sporadic breast cancerTranslational Research at the Aging and Cancer Interface.Changes Associated with Aging. Cancer Res 2004, 64:8550-

2007-01-01T23:59:59.000Z

444

Natural Versus Artificial Aging of Nuclear Power Plant Components  

Science Conference Proceedings (OSTI)

Examination of test specimens, placed in eight operating reactors during this study, will provide information on the long-term aging effects of plant environments on cabling and electrical components. Material property data, when compared with measured degradation in artificially aged specimens, will help improve predictions of the safe, useful life of plant equipment.

1986-12-31T23:59:59.000Z

445

Nuclear power plant Generic Aging Lessons Learned (GALL). Appendix B  

SciTech Connect

The purpose of this generic aging lessons learned (GALL) review is to provide a systematic review of plant aging information in order to assess materials and component aging issues related to continued operation and license renewal of operating reactors. Literature on mechanical, structural, and thermal-hydraulic components and systems reviewed consisted of 97 Nuclear Plant Aging Research (NPAR) reports, 23 NRC Generic Letters, 154 Information Notices, 29 Licensee Event Reports (LERs), 4 Bulletins, and 9 Nuclear Management and Resources Council Industry Reports (NUMARC IRs) and literature on electrical components and systems reviewed consisted of 66 NPAR reports, 8 NRC Generic Letters, 111 Information Notices, 53 LERs, 1 Bulletin, and 1 NUMARC IR. More than 550 documents were reviewed. The results of these reviews were systematized using a standardized GALL tabular format and standardized definitions of aging-related degradation mechanisms and effects. The tables are included in volume s 1 and 2 of this report. A computerized data base has also been developed for all review tables and can be used to expedite the search for desired information on structures, components, and relevant aging effects. A survey of the GALL tables reveals that all ongoing significant component aging issues are currently being addressed by the regulatory process. However, the aging of what are termed passive components has been highlighted for continued scrutiny. This report consists of Volume 2, which consists of the GALL literature review tables for the NUMARC Industry Reports reviewed for the report.

Kasza, K.E.; Diercks, D.R.; Holland, J.W.; Choi, S.U. [and others

1996-12-01T23:59:59.000Z

446

The effect of chrome adhesion layer on quartz resonator aging.  

Science Conference Proceedings (OSTI)

This SAND report documents a late start LDRD designed to determine the possible aging effects of a quartz resonator gold adhesion layer. Sandia uses quartz resonators for applications. These applications require a very stable frequency source with excellent aging (low drift) characteristics. These parts are manufactured by one of our qualified vendors outside Sandia Laboratories, Statek Corp. Over the years we, Sandia and the vendor, have seen aging variations that have not been completely explained by the typical mechanisms known in the industry. One theory was that the resonator metallization may be contributing to the resonator aging. This LDRD would allow us to test and analyze a group of resonators with known differentiating metallization and via accelerated aging determine if a chrome adhesion layer used to accept the final gold plating may contribute to poor aging. We worked with our main vendor to design and manufacture a set of quartz resonators with a wide range of metallization thickness ratios between the chrome and gold that will allow us determine the cause of this aging and which plating thickness ratios provide the best aging performance while not degrading other key characteristics.

Wessendorf, Kurt O.; Ohlhausen, James Anthony

2011-03-01T23:59:59.000Z

447

Aging and user disfunctionings: implications for information system design  

Science Conference Proceedings (OSTI)

Researches in ergonomics are carried out on factors of work inducing a premature ageing or pathologies, with the purpose of designing or improving workplaces, devices and organisations less noxious for the health or more compatible with possible handicaps ... Keywords: ageing, elderly, ergonomics

Jean-Claude Sperandio

2003-11-01T23:59:59.000Z

448

The effects of aging on BWR core isolation cooling systems  

Science Conference Proceedings (OSTI)

A study was performed to assess the effects of aging on the Reactor Core Isolation Cooling (RCIC) system in commercial Boiling Water Reactors (BWRs). This study is part of the Nuclear Plant Aging Research (NPAR) program sponsored by the US Nuclear Regulatory Commission. The objectives of this program are to provide an understanding of the aging process and how it affects plant safety so that it can be properly managed. This is one of a number of studies performed under the NPAR program which provide a technical basis for the identification and evaluation of degradation caused by age. The failure data from national databases, as well as plant specific data were reviewed and analyzed to understand the effects of aging on the RCIC system. This analysis identified important components that should receive the highest priority in terms of aging management. The aging characterization provided information on the effects of aging on component failure frequency, failure modes, and failures causes. Current inspection, surveillance, and monitoring practices were also reviewed.

Lee, B.S. [Brookhaven National Lab., Upton, NY (United States)

1994-10-01T23:59:59.000Z

449

Twin boundary cavitation in aged type 304 stainless steel  

SciTech Connect

A transition from grain to twin boundary cavitation was observed in aged- and-creep-tested type 304 stainless steel. Evidence of twin boundary cavitation has also been observed for unaged material under certain test conditions. This same behavior was also found in aged type 316 stainless steel. Several possible reasons have been suggested for the absence of frequently observed grain boundary cavitation. (auth)

Sikka, V.K.; Swindeman, R.W.; Brinkman, C.R.

1975-10-01T23:59:59.000Z

450

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Enzyme Structure Provides Insights into Cancer and Aging Print Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum (XP), extreme sensitivity to sunlight promotes cancer; Cockayne syndrome (CS) involves stunted growth and premature aging; trichothiodystrophy (TTD), characterized by brittle hair and scaly skin, is another form of greatly accelerated aging. At the ALS, researchers from Berkeley Lab and The Scripps Research Institute recently solved the structure of XPD. The structure gives novel insight into the processes of aging and cancer by revealing how discrete flaws-as seemingly insignificant as a change in either of two adjacent amino acid residues-can lead to diseases with completely different physical manifestations.

451

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Enzyme Structure Provides Insights into Cancer and Aging Print Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum (XP), extreme sensitivity to sunlight promotes cancer; Cockayne syndrome (CS) involves stunted growth and premature aging; trichothiodystrophy (TTD), characterized by brittle hair and scaly skin, is another form of greatly accelerated aging. At the ALS, researchers from Berkeley Lab and The Scripps Research Institute recently solved the structure of XPD. The structure gives novel insight into the processes of aging and cancer by revealing how discrete flaws-as seemingly insignificant as a change in either of two adjacent amino acid residues-can lead to diseases with completely different physical manifestations.

452

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Enzyme Structure Provides Insights into Cancer and Aging Print Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum (XP), extreme sensitivity to sunlight promotes cancer; Cockayne syndrome (CS) involves stunted growth and premature aging; trichothiodystrophy (TTD), characterized by brittle hair and scaly skin, is another form of greatly accelerated aging. At the ALS, researchers from Berkeley Lab and The Scripps Research Institute recently solved the structure of XPD. The structure gives novel insight into the processes of aging and cancer by revealing how discrete flaws-as seemingly insignificant as a change in either of two adjacent amino acid residues-can lead to diseases with completely different physical manifestations.

453

Property:HostRockAge | Open Energy Information  

Open Energy Info (EERE)

HostRockAge HostRockAge Jump to: navigation, search Property Name HostRockAge Property Type String Description Describes the age of the reservoir rock by epoch, era, or period per available data. This is a property of type Page. Subproperties This property has the following 10 subproperties: B Beowawe Hot Springs Geothermal Area Brady Hot Springs Geothermal Area C Chena Geothermal Area D Desert Peak Geothermal Area G Geysers Geothermal Area R Raft River Geothermal Area Roosevelt Hot Springs Geothermal Area S Salton Sea Geothermal Area Steamboat Springs Geothermal Area W Wabuska Hot Springs Geothermal Area Pages using the property "HostRockAge" Showing 11 pages using this property. A Amedee Geothermal Area + Mesozoic + B Blue Mountain Geothermal Area + Triassic + C Coso Geothermal Area + Mesozoic +

454

The role of aging in resolving the ferrocyanide safety issue  

Science Conference Proceedings (OSTI)

A chemical process called aging, in which stored ferrocyanide waste could be dissolved and dispersed among waste tanks, or destroyed by radiolysis and hydrolysis, has been proposed at the Hanford Site. This paper summarizes the results of applied research, characterization, and modeling activities on Hanford Site ferrocyanide waste material that support the existence of a chemical aging mechanism. Test results from waste simulants and actual waste tank materials are presented and compared with theoretical estimates. Chemical and energetic behavior of the materials are the key indicators of destruction or dispersion. Screening experiments on vendor-prepared sodium nickel ferrocyanide and the initial results from core sampling support the concept that aging of ferrocyanide is taking place in the waste tanks at the Hanford Site. This report defines the concept of waste aging and explains the role that aging could play in resolving the Hanford Site ferrocyanide safety issue.

Babad, H.; Meacham, J.E.; Simpson, B.C.; Cash, R.J.

1993-08-01T23:59:59.000Z

455

Catastrophic senescence and semelparity in the Penna aging model  

E-Print Network (OSTI)

The catastrophic senescence of the Pacific salmon is among the initial tests used to validate the Penna aging model. Based on the mutation accumulation theory, the sudden decrease in fitness following reproduction may be solely attributed to the semelparity of the species. In this work, we report other consequences of mutation accumulation. Contrary to earlier findings, such dramatic manifestation of aging depends not only on the choice of breeding strategy but also on the value of the reproduction age, R, and the mutation threshold, T. Senescence is catastrophic when T\\leq R. As the organism's tolerance for harmful genetic mutations increases, the aging process becomes more gradual. We observe senescence that is threshold dependent whenever T>R. That is, the sudden drop in survival rate occurs at age equal to the mutation threshold value.

Pinol, C M N

2010-01-01T23:59:59.000Z

456

The distribution of stellar population age in galactic bars  

E-Print Network (OSTI)

Recent analysis of stellar populations in barred galaxies have focused on the spatial distribution of stellar population ages and metallicities. However, barred galaxies are complex objects where dynamical instabilities play a leading role in shaping any spatial distribution. The age distribution of stellar populations should thus be analyzed from the two points of view of stellar population evolution and dynamical secular evolution. Chemodynamical simulations of single barred galaxies with simple but realistic star formation and feedback recipes are used to produce face-on mass-weighted maps of stellar population ages. Luminosity-weighted maps in V-band are also displayed after calibrating the simulation with mass-to-light ratios provided by a synthesis population model. It is shown that inside a stellar bar two persistent diametrically opposed regions display a mean age lower than the surrounding average. These two low-age regions are due to the accumulation of young stellar populations trapped on elliptica...

Wozniak, H

2007-01-01T23:59:59.000Z

457

Aging management guideline for commercial nuclear power plants-pumps  

SciTech Connect

This Aging Management Guideline (AMG) describes recommended methods for effective detection and mitigation of age-related degradation mechanisms in BWR and PWR commercial nuclear power plant pumps important to license renewal. The intent of this AMG is to assist plant maintenance and operations personnel in maximizing the safe, useful life of these components. It also supports the documentation of effective aging management programs required under the License Renewal Rule 10 CFR Part 54. This AMG is presented in a manner that allows personnel responsible for performance analysis and maintenance to compare their plant-specific aging mechanisms (expected or already experienced) and aging management program activities to the more generic results and recommendations presented herein.

Booker, S.; Katz, D.; Daavettila, N.; Lehnert, D. [MDC-Ogden Environmental and Energy Services, Southfield, MI (United States)

1994-03-01T23:59:59.000Z

458

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Enzyme Structure Provides Insights into Cancer and Aging Print Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum (XP), extreme sensitivity to sunlight promotes cancer; Cockayne syndrome (CS) involves stunted growth and premature aging; trichothiodystrophy (TTD), characterized by brittle hair and scaly skin, is another form of greatly accelerated aging. At the ALS, researchers from Berkeley Lab and The Scripps Research Institute recently solved the structure of XPD. The structure gives novel insight into the processes of aging and cancer by revealing how discrete flaws-as seemingly insignificant as a change in either of two adjacent amino acid residues-can lead to diseases with completely different physical manifestations.

459

Globular Cluster Ages and the Formation of the Galactic Halo  

E-Print Network (OSTI)

Main sequence turnoff magnitudes from the recent set of Yale isochrones (Chaboyer \\ea 1995) have been combined with a variety of relations for the absolute magnitude of RR Lyr stars (\\mvrr) to calibrate age as a function of the difference in magnitude between the main sequence turn-off and the horizontal branch (\\dv). A best estimate for the calibration of \\mvrr is derived from a survey of the current literature: $\\mvrr = 0.20 \\feh + 0.98$. This estimate, together with other calibrations (with slopes ranging from 0.15 to 0.30) has been used to derive \\dv ages for 43 Galactic globular clusters. Independent of the choice of \\mvrr, there is no strong evidence for an age-Galacto\\-centric distance relationship among the 43 globular clusters. However, an age-metallicity relation exists, with the metal-poor clusters being the oldest. A study of the age distribution reveals that an age range of 5 Gyr exists among the bulk of the globular clusters. In addition, about 10\\% of the sample are substantially younger, and including them in the analysis increases the age range to 9 Gyr. Once again, these statements are independent of the \\mvrr ~relation. Evidence for age being the second parameter governing horizontal branch morphology is found by comparing the average \\dv ~age of the second parameter clusters to the normal clusters. The second parameter clusters are found to be on average 2 - 3 Gyr younger than the other clusters, which is consistent with age being the second parameter. These results suggest that globular clusters were formed over an extended period of time, with progressively more metal-rich globular clusters ($\\feh \\ga -1.7$) being formed at later times.

Brian Chaboyer; P. Demarque; Ata Sarajedini

1995-09-12T23:59:59.000Z

460

An assessment of fire vulnerability for aged electrical relays  

SciTech Connect

There has been some concern that, as nuclear power plants age, protective measures taken to control and minimize the impact of fire may become ineffective, or significantly less effective, and hence result in an increased fire risk. One objective of the Fire Vulnerability of Aged Electrical Components Program is to assess the effects of aging and service wear on the fire vulnerability of electrical equipment. An increased fire vulnerability of components may lead to an overall increase in fire risk to the plant. Because of their widespread use in various electrical safety systems, electromechanical relays were chosen to be the initial components for evaluation. This test program assessed the impact of operational and thermal aging on the vulnerability of these relays to fire-induced damage. Only thermal effects of a fire were examined in this test program. The impact of smoke, corrosive materials, or fire suppression effects on relay performance were not addressed in this test program. The purpose of this test program was to assess whether the fire vulnerability of electrical relays increased with aging. The sequence followed for the test program was to: identify specific relay types, develop three fire scenarios, artificially age several relays, test the unaged and aged relays in the fire exposure scenarios, and compare the results. The relays tested were Agastat GPI, General Electric (GE) HMA, HGA, and HFA. At least two relays of each type were artificially aged and at least two relays of each type were new. Relays were operationally aged by cycling the relay under rated load for 2,000 operations. These relays were then thermally aged for 60 days with their coil energized.

Vigil, R.A. [Sandia National Labs., Albuquerque, NM (United States)]|[Science and Engineering Associates, Inc., Albuquerque, NM (United States); Nowlen, S.P. [Sandia National Labs., Albuquerque, NM (United States)

1995-03-01T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

The Health of Aging Lesbian, Gay and Bisexual Adults in California  

E-Print Network (OSTI)

March 2011 The Health of Aging Lesbian, Gay and Bisexualpopulation-level data on aging LGB adults (ages 50-70)care appears similar for aging LGB and heterosexual adults,

Wallace, Steven P.; Cochran, Susan D.; Durazo, Eva M.; Ford, Chandra L.

2011-01-01T23:59:59.000Z

462

Medical Waiver Male participants over 45 years of age and female participants over 55 years of age are required  

E-Print Network (OSTI)

Medical Waiver Male participants over 45 years of age and female participants over 55 years of age are required to submit a Medical Waiver signed by their physician before participation in the Recreation of heart disease) are required to submit the Medical Waiver signed by their physician regardless

Spence, Harlan Ernest

463

Manhattan Project: Early Government Support, 1939-1942  

Office of Scientific and Technical Information (OSTI)

Albert Einstein and Leo Szilard EARLY GOVERNMENT SUPPORT Albert Einstein and Leo Szilard EARLY GOVERNMENT SUPPORT (1939-1942) Events Einstein's Letter, 1939 Early Uranium Research, 1939-1941 Piles and Plutonium, 1939-1941 Reorganization and Acceleration, 1940-1941 The MAUD Report, 1941 A Tentative Decision to Build the Bomb, 1941-1942 As the news of the fission breakthrough spread from Berlin in early 1939, many physicists within the United States (and elsewhere) immediately realized the potential danger posed by atomic energy. Especially concerned were émigré physicists who had fled their native countries because of the expansion of Nazi Germany and sought to obtain governmental support for further, secret nuclear research. Convincing busy government officials of the seriousness of this esoteric new scientific development was at first slow going. One month before the Second World War formally began with the September 1, 1939, invasion of Poland by Nazi Germany, Leo Szilard enlisted the help of Albert Einstein in personally calling President Franklin Roosevelt's attention to the matter. Roosevelt responded by creating a government committee to coordinate and provide modest funding for early uranium research. Work also proceeded during this period on the design of an atomic pile that could demonstrate the potential of atomic energy and possibly provide a second path to the atomic bomb besides uranium.

464

Manhattan Project: Early Uranium Research, 1939-1941  

Office of Scientific and Technical Information (OSTI)

Ernest Lawrence, Arthur Compton, Vannevar Bush, and James Conant discuss uranium research, Berkeley, March 29, 1940. EARLY URANIUM RESEARCH Ernest Lawrence, Arthur Compton, Vannevar Bush, and James Conant discuss uranium research, Berkeley, March 29, 1940. EARLY URANIUM RESEARCH (1939-1941) Events > Early Government Support, 1939-1942 Einstein's Letter, 1939 Early Uranium Research, 1939-1941 Piles and Plutonium, 1939-1941 Reorganization and Acceleration, 1940-1941 The MAUD Report, 1941 A Tentative Decision to Build the Bomb, 1941-1942 President Franklin D. Roosevelt responded to the call for government support of uranium research quickly but cautiously. He appointed Lyman J. Briggs, director of the National Bureau of Standards, head of the Advisory Committee on Uranium, which met for the first time on October 21, 1939. The committee, including both civilian and military representation, was to coordinate its activities with Alexander Sachs and look into the current state of research on uranium to recommend an appropriate role for the federal government. In early 1940, only months after the outbreak of war in Europe, the Uranium Committee recommended that the government fund limited research on isotope separation as well as Enrico Fermi's and Leo Szilard's work on fission chain reactions at Columbia University (below).

465

The Construction of Early Modernity in Spanish Film  

E-Print Network (OSTI)

The presence of early modern Spanish history in Spanish film has received only limited scholarly attention. The entire group of Spanish films dealing with the Spanish early modern era has never been placed under study by any overarching research. This dissertation reframes the evolution of the cinematographic representation of the Spanish past as it studies the mechanisms employed by Spanish films in representing an essential part of Spanish past: early modernity. Studied are 19 period films that group themselves around some of most representative subjects in early modernity: the Monarchy and Nobility, and the Spanish Inquisition. Studied also is the most expensive Spanish period film, Alatriste (2006). Through the analysis of artistic, industrial, historiographical, and political elements, and the deconstruction of the historical message of each film, as well as the analysis of their reception, it is clear that Spanish period films set in early modernity tell us as much about the time of their making and the shaping of the historical consciousness of Spain as they do about the era that they represent on screen.

Zarate Casanova, Miguel Angel

2011-08-01T23:59:59.000Z

466

Comparative Effectiveness of 5 Treatment Strategies for Early-Stage Non-Small Cell Lung Cancer in the Elderly  

SciTech Connect

Purpose: The incidence of early-stage non-small cell lung cancer (NSCLC) among older adults is expected to increase because of demographic trends and computed tomography-based screening; yet, optimal treatment in the elderly remains controversial. Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare cohort spanning 2001-2007, we compared survival outcomes associated with 5 strategies used in contemporary practice: lobectomy, sublobar resection, conventional radiation therapy, stereotactic ablative radiation therapy (SABR), and observation. Methods and Materials: Treatment strategy and covariates were determined in 10,923 patients aged {>=}66 years with stage IA-IB NSCLC. Cox regression, adjusted for patient and tumor factors, compared overall and disease-specific survival for the 5 strategies. In a second exploratory analysis, propensity-score matching was used for comparison of SABR with other options. Results: The median age was 75 years, and 29% had moderate to severe comorbidities. Treatment distribution was lobectomy (59%), sublobar resection (11.7%), conventional radiation (14.8%), observation (12.6%), and SABR (1.1%). In Cox regression analysis with a median follow-up time of 3.2 years, SABR was associated with the lowest risk of death within 6 months of diagnosis (hazard ratio [HR] 0.48; 95% confidence interval [CI] 0.38-0.63; referent is lobectomy). After 6 months, lobectomy was associated with the best overall and disease-specific survival. In the propensity-score matched analysis, survival after SABR was similar to that after lobectomy (HR 0.71; 95% CI 0.45-1.12; referent is SABR). Conventional radiation and observation were associated with poor outcomes in all analyses. Conclusions: In this population-based experience, lobectomy was associated with the best long-term outcomes in fit elderly patients with early-stage NSCLC. Exploratory analysis of SABR early adopters suggests efficacy comparable with that of surgery in select populations. Evaluation of these therapies in randomized trials is urgently needed.

Shirvani, Shervin M. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Jiang, Jing [Department of Biostatistics and Applied Mathematics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Biostatistics and Applied Mathematics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chang, Joe Y.; Welsh, James W.; Gomez, Daniel R. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Swisher, Stephen [Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Thoracic and Cardiovascular Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Buchholz, Thomas A. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Smith, Benjamin D., E-mail: bsmith3@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

2012-12-01T23:59:59.000Z

467

SURVEY AND SUMMARY Role of RNA helicases in HIV-1 replication  

E-Print Network (OSTI)

Viruses are replication competent genomes which are relatively gene-poor. Even the largest viruses (i.e. Herpesviruses) encode only slightly.200 open reading frames (ORFs). However, because viruses replicate obligatorily inside cells, and considering that evolution may be driven by a principle of economy of scale, it is reasonable to surmise that many viruses have evolved the ability to co-opt cell-encoded proteins to provide needed surrogate functions. An in silico survey of viral sequence databases reveals that most positive-strand and double-stranded RNA viruses have ORFs for RNA helicases. On the other hand, the genomes of retroviruses are devoid of virally-encoded helicase. Here, we review in brief the notion that the human immunodeficiency virus (HIV-1) has adopted the ability to use one or more cellular RNA helicases for its replicative life cycle.

Kuan-teh Jeang; Venkat Yedavalli

2006-01-01T23:59:59.000Z

468

The Relative Age of the Thin and Thick Galactic Disks  

E-Print Network (OSTI)

We determine the relative ages of the open cluster NGC 188 and selected Hipparcos field stars by isochrone fitting, and compare them to the age of the thick disk globular cluster 47 Tuc. The best fit age for NGC 188 was determined to be $6.5 \\pm 1.0$ Gyr. The solar metallicity Hipparcos field stars yielded a slightly older thin disk age, $7.5 \\pm 0.7$ Gyr. Two slightly metal-poor ($\\feh = -0.22$) field stars whose kinematic and orbital parameters indicate that they are members of the thin disk were found to have an age of $9.7\\pm 0.6$ Gyr. The age for 47 Tuc was determined to be $12.5 \\pm 1.5$ Gyr. All errors are internal errors due to the uncertainty in the values of metallicity and reddening. Thus, the oldest stars dated in the thin disk are found to be $2.8\\pm 1.6$ Gyr younger than 47 Tuc. Furthermore, as discussed by \\citet{Chb99} 47 Tuc has a similar age to three globular clusters located in the inner part of the Galactic halo, implying that star formation in the thin disk started within $2.8\\pm 1.6$ Gyr of star formation in the halo.

Wilson M. Liu; Brian Chaboyer

2000-07-13T23:59:59.000Z

469

Recommendations for the treatment of aging in standard technical specifications  

Science Conference Proceedings (OSTI)

As part of the US Nuclear Regulatory Commission`s Nuclear Plant Aging Research Program, Pacific Northwest Laboratory (PNL) evaluated the standard technical specifications for nuclear power plants to determine whether the current surveillance requirements (SRs) were effective in detecting age-related degradation. Nuclear Plant Aging Research findings for selected systems and components were reviewed to identify the stressors and operative aging mechanisms and to evaluate the methods available to detect, differentiate, and trend the resulting aging degradation. Current surveillance and testing requirements for these systems and components were reviewed for their effectiveness in detecting degraded conditions and for potential contributions to premature degradation. When the current surveillance and testing requirements appeared ineffective in detecting aging degradation or potentially could contribute to premature degradation, a possible deficiency in the SRs was identified that could result in undetected degradation. Based on this evaluation, PNL developed recommendations for inspection, surveillance, trending, and condition monitoring methods to be incorporated in the SRs to better detect age- related degradation of these selected systems and components.

Orton, R.D.; Allen, R.P.

1995-09-01T23:59:59.000Z

470

Aging phenomena in PMMA thin films -- memory and rejuvenation effects  

E-Print Network (OSTI)

Aging dynamics in thin films of poly(methyl methacrylate) (PMMA) have been investigated through dielectric measurements for different types of aging processes. The dielectric constant was found to decrease with increasing aging time at an aging temperature in many cases. An increase in the dielectric constant was also observed in the long time region ($\\ge$11h) near the glass transition temperature for thin films with thickness less than 26nm. In the constant rate mode including a temporary stop at a temperature $T_a$, the memory of the aging at $T_a$ was found to be kept and then to be recalled during the subsequent heating process. In the negative temperature cycling process, a strong rejuvenation effect has been observed after the temperature shift from the initial temperature $T_1$ to the second temperature $T_2$($=T_1+\\Delta T$) when $\\Delta T\\approx -20$K. Furthermore, a full memory effect has also been observed for the temperature shift from $T_2$ to $T_1$. This suggests that the aging at $T_1$ is totally independent of that at $T_2$ for $\\Delta T\\approx -20$K. As $|\\Delta T|$ decreases, the independence of the aging between the two temperatures was found to be weaken, $i.e.,$ the effective time, which is a measure of the contribution of the aging at $T_1$ to that at $T_2$, is a decreasing function of $|\\Delta T|$ in the negative region of $\\Delta T$. As the film thickness decreases from 514nm to 26nm, the $|\\Delta T|$ dependence of the effective time was found to become much stronger. The contribution of the aging at $T_2$ to that at $T_1$ disappears more rapidly with increasing $|\\Delta T|$ in thin film geometry than in the bulk state.

Koji Fukao; Aiko Sakamoto

2004-10-23T23:59:59.000Z

471

AGE-1 WALLEYE POLLOCK IN THE EASTERN BERING SEA: DISTRIBUTION, ABUNDANCE, DIET, AND ENERGY DENSITY  

E-Print Network (OSTI)

AGE-1 WALLEYE POLLOCK IN THE EASTERN BERING SEA: DISTRIBUTION, ABUNDANCE, DIET, AND ENERGY DENSITY performed at sea · Energy density estimated using bomb calorimetry for samples from BASIS and MACE surveys · Confirm ages of age-0 and age-1 pollock using otoliths · Distribution of age-1's further north than age-0

472

Early Argonne reactor lit the way for worldwide nuclear industry -  

NLE Websites -- All DOE Office Websites (Extended Search)

Early Argonne reactor lit the way for worldwide Early Argonne reactor lit the way for worldwide nuclear industry About Director's Welcome Organization Achievements Highlights Fact Sheets, Brochures & Other Documents Multimedia Library Visit Argonne Work with Argonne Contact us Nuclear Energy Why Nuclear Energy? Why are some people afraid of Nuclear Energy? How do nuclear reactors work? Cheaper & Safer Nuclear Energy Helping to Solve the Nuclear Waste Problem Nuclear Reactors Nuclear Reactors Early Exploration Training Reactors Basic and Applied Science Research LWR Technology Development BORAX-III lighting Arco, Idaho (Press Release) Heavy Water and Graphite Reactors Fast Reactor Technology Integral Fast Reactor Argonne Reactor Tree CP-1 70th Anniversary CP-1 70th Anniversary Argonne's Nuclear Science and Technology Legacy

473

United States Annual Energy Outlook 2012 (Early Release) | Open Energy  

Open Energy Info (EERE)

Annual Energy Outlook 2012 (Early Release) Annual Energy Outlook 2012 (Early Release) Jump to: navigation, search Tool Summary LAUNCH TOOL Name: United States Annual Energy Outlook 2012 (Early Release) Focus Area: Other Renewable Electricity Topics: Market Analysis Website: www.eia.gov/forecasts/aeo/er/ Equivalent URI: cleanenergysolutions.org/content/united-states-annual-energy-outlook-2 Language: English Policies: "Deployment Programs,Regulations" is not in the list of possible values (Deployment Programs, Financial Incentives, Regulations) for this property. DeploymentPrograms: Technical Assistance Regulations: Utility/Electricity Service Costs The Annual Energy Outlook 2012 (AEO2012) reference case overview evaluates a wide range of trends and issues that could have major implications for

474

Annual Energy Outlook 2013 Early Release Reference Case  

Gasoline and Diesel Fuel Update (EIA)

Early Release Reference Case Early Release Reference Case AEO2013 Early Release Rollout Presentation Paul H. Nitze School of Advanced International Studies Johns Hopkins University December 5, 2012 | Washington, D.C. by Adam Sieminski, Administrator Key results from the AEO2013 Reference case: 2 * Growth in energy production outstrips consumption growth * Crude oil production, particularly from tight oil plays, rises sharply over the next decade * Natural gas production is higher throughout the Reference case projection than it was in AEO2012, serving the industrial and power sectors and an expanding export market * Motor gasoline consumption reflects the introduction of more stringent fuel economy standards, while diesel fuel consumption is moderated by increased natural gas use in heavy-duty vehicles

475

A Path to Successful Energy Retrofits: Early Collaboration Through  

NLE Websites -- All DOE Office Websites (Extended Search)

Through Through Integrated Project Delivery Teams Title A Path to Successful Energy Retrofits: Early Collaboration Through Integrated Project Delivery Teams Publication Type Report Refereed Designation Refereed LBNL Report Number LBNL-6130E Year of Publication 2012 Authors Parrish, Kristen Date Published 10/2012 Publisher Lawrence Berkeley National Laboratory Abstract This document guides you through a process for the early design phases of retrofit projects to help you mitigate frustrations commonly experienced by building owners and designers. It outlines the value of forming an integrated project delivery team and developing a communication and information-sharing infrastructure that fosters collaboration. This guide does not present a complete process for designing an energy retrofit for a building. Instead, it focuses on the early design phase tasks related to developing and selecting energy efficiency measures (EEMs) that benefit from collaboration, and highlights the resulting advantages.

476

Presidential Early Career Awards for Scientists and Engineers Award  

Office of Science (SC) Website

Transcribed Media Home » About » Honors and Transcribed Media Home » About » Honors and Awards » PECASE » 2012 » Presidential Early Career Awards for Scientists and Engineers Award Ceremony Introduction Transcribed Media Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 P: (202) 586-5430 2012 Presidential Early Career Awards for Scientists and Engineers Award Ceremony Introduction Print Text Size: A A A RSS Feeds FeedbackShare Page Inspiration...Achievement...Promise That's what we're celebrating today. The 13 Department of Energy winners of the Presidential Early Career Awards for Scientists and Engineers were chosen from among their peers as the best in achievement; the brightest in promise. As PECASE winners, they have earned the highest honor our

477

PREVENTIVE MAINTENANCE LEADS TO EARLY DETECTION AT WIPP SITE | Department  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

PREVENTIVE MAINTENANCE LEADS TO EARLY DETECTION AT WIPP SITE PREVENTIVE MAINTENANCE LEADS TO EARLY DETECTION AT WIPP SITE PREVENTIVE MAINTENANCE LEADS TO EARLY DETECTION AT WIPP SITE September 1, 2011 - 12:00pm Addthis The new wire rope before installation. The new wire rope before installation. URS Washington TRU Solutions operations and maintenance crews demonstrate exceptional performance to replace a steel rope. URS Washington TRU Solutions operations and maintenance crews demonstrate exceptional performance to replace a steel rope. The new wire rope before installation. URS Washington TRU Solutions operations and maintenance crews demonstrate exceptional performance to replace a steel rope. Carlsbard, NM - The effectiveness of the Waste Isolation Pilot Plant's (WIPP) preventive maintenance program paid huge dividends late last month

478

step toward the project's planned early 2011 startup. The project  

NLE Websites -- All DOE Office Websites (Extended Search)

step toward the project's planned early 2011 startup. The project step toward the project's planned early 2011 startup. The project will capture CO 2 from the Archer Daniels Midland (ADM) Ethanol Production Facility and inject it into a deep saline reservoir more than one mile underground. Beginning in early 2011, up to 1 million metric tons of the captured CO 2 will be compressed into a dense, liquid-like state and injected over a three-year period. The Mt. Simon Sandstone, which is the rock formation targeted for the injection, is the thickest and most widespread saline reservoir in the Illinois Basin, with an estimated CO 2 storage capacity as high as 110 billion metric tons. Analysis of the survey data is a key component in the comprehensive monitoring program that will be implemented to ensure the injected

479

The Consortium for Social Work Training in Aging: Schools of social work in partnership with county departments of adult and aging services  

E-Print Network (OSTI)

knowledge and misconceptions about aging: Responses toPalmore's Facts on Aging quizzes. The Ger- ontologist,32,of Palmore's second facts on aging quiz from a true-false to

Scharlach, Andrew E; Robinson, B K

2005-01-01T23:59:59.000Z

480

Phenomenology of ageing in the Kardar-Parisi-Zhang equation  

E-Print Network (OSTI)

We study ageing during surface growth processes described by the one-dimensional Kardar-Parisi-Zhang equation. Starting from a flat initial state, the systems undergo simple ageing in both correlators and linear responses and its dynamical scaling is characterised by the ageing exponents a=-1/3, b=-2/3, lambda_C=lambda_R=1 and z=3/2. The form of the autoresponse scaling function is well described by the recently constructed logarithmic extension of local scale-invariance.

Malte Henkel; Jae Dong Noh; Michel Pleimling

2011-09-23T23:59:59.000Z

Note: This page contains sample records for the topic "hiv early aging" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


481

Forecasting cosmological constraints from age of high-z galaxies  

E-Print Network (OSTI)

We perform Monte Carlo simulations based on current age estimates of high-z objects to forecast constraints on the equation of state (EoS) of the dark energy. In our analysis, we use two different EoS parameterizations, namely, the so-called CPL and its uncorrelated form and calculate the improvements on the figure of merit for both cases. Although there is a clear dependence of the FoM with the size and accuracy of the synthetic age samples, we find that the most substantial gain in FoM comes from a joint analysis involving age and baryon acoustic oscillation data.

C. A. P. Bengaly Jr.; M. A. Dantas; J. C. Carvalho; J. S. Alcaniz

2013-08-28T23:59:59.000Z

482

The Consortium for Social Work Training in Aging: Schools of social work in partnership with county departments of adult and aging services  

E-Print Network (OSTI)

THE CONSORTIUM FOR SOCIAL WORK TRAINING IN AGING: SCHOOLS OFan innovative collaborative training model that includedand aging services, and enhanced training capacity of county

Scharlach, Andrew E; Robinson, B K

2005-01-01T23:59:59.000Z

483

Enzyme Structure Provides Insights into Cancer and Aging  

NLE Websites -- All DOE Office Websites (Extended Search)

Bioscience Bioscience Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism that maintains the integrity of DNA. XPD is unique, however, in that pinpoint mutations of this single protein are responsible for three different human diseases: in xeroderma pigmentosum (XP), extreme sensitivity to sunlight promotes cancer; Cockayne syndrome (CS) involves stunted growth and premature aging; trichothiodystrophy (TTD), characterized by brittle hair and scaly skin, is another form of greatly accelerated aging. At the ALS, researchers from Berkeley Lab and The Scripps Research Institute recently solved the structure of XPD. The structure gives novel insight into the processes of aging and cancer by revealing how discrete flaws-as seemingly insignificant as a change in either of two adjacent amino acid residues-can lead to diseases with completely different physical manifestations.

484

Author age prediction from text using linear regression  

Science Conference Proceedings (OSTI)

While the study of the connection between discourse patterns and personal identification is decades old, the study of these patterns using language technologies is relatively recent. In that more recent tradition we frame author age prediction from text ...

Dong Nguyen; Noah A. Smith; Carolyn P. Rosé

2011-06-01T23:59:59.000Z

485

Space-Age Ceramics Get Their Toughest Test  

NLE Websites -- All DOE Office Websites (Extended Search)

Space-Age Ceramics Get Their Space-Age Ceramics Get Their Toughest Test Space-Age Ceramics Get Their Toughest Test Print Wednesday, 17 April 2013 07:23 Advanced ceramic composites can withstand the ultrahigh operational temperatures projected for hypersonic jet and next-generation gas-turbine engines, but real-time analysis of the mechanical properties of these space-age materials at ultrahigh temperatures has been a challenge-until now. Researchers have developed the first testing facility that enables microtomography of ceramic composites under controlled loads at ultrahigh temperatures and in real-time. Using this facility, they have fully resolved sequences of microcrack damage as cracks grow under load at temperatures several hundred degrees higher than previously possible. The observations are key ingredients of the high-fidelity simulations used to compute failure risks under extreme operating conditions.

486

Tensile-property characterization of thermally aged cast stainless steels  

Science Conference Proceedings (OSTI)

The effect of thermal aging on tensile properties of cast stainless steels during service in light water reactors has been evaluated. Tensile data for several experimental and commercial heats of cast stainless steels are presented. Thermal aging increases the tensile strength of these steels. The high-C Mo-bearing CF-8M steels are more susceptible to thermal aging than the Mo-free CF-3 or CF-8 steels. A procedure and correlations are presented for predicting the change in tensile flow and yield stresses and engineering stress-vs.-strain curve of cast stainless steel as a function of time and temperature of service. The tensile properties of aged cast stainless steel are estimated from known material information, i.e., chemical composition and the initial tensile strength of the steel. The correlations described in this report may be used for assessing thermal embrittlement of cast stainless steel components.

Michaud, W.F.; Toben, P.T.; Soppet, W.K.; Chopra, O.K. [Argonne National Lab., IL (United States)

1994-02-01T23:59:59.000Z

487

Influence of Zn Additions on Age Hardening Response and ...  

Science Conference Proceedings (OSTI)

... on Age Hardening Response and Microstructure of Mg-0.3at.%Ca Alloys. Author(s), Keiichiro Oh-ishi, Chamini L Mendis, Ryuichi Watanabe, Kazuhiro Hono.

488

Users, technology and space in libraries in the digital age  

E-Print Network (OSTI)

This thesis is a user research study of emerging issues in the use of libraries as public spaces and as information repositories in the digital age. Till recently strong physicality was attached to the library with the ...

G-Chandorkar, Tripti (Gore-Chandorkar)

2005-01-01T23:59:59.000Z

489

Mo Type Phase in Long-Term Aged INCONEL Alloy  

Science Conference Proceedings (OSTI)

FORMATION OF A PtzMo TYPE PHASE IN LONG-TERM AGED lNCONEL@ ALLOY 686. Michael G. ... formation of a low-temperature iutermetallic Pt*Mo type .

490

Compressive Seal Development: Combined Ageing and Thermal Cycling Compressive  

DOE Green Energy (OSTI)

The objective of this project was to evaluate the combined aging and cycling effect on hybrid Phlogopite mica seals with respect to materials and interfacial degradations in a simulated SOFC environment.

Chou, M.Y-S.; Stevenson, J.W.; Singh, P.

2005-01-27T23:59:59.000Z