National Library of Energy BETA

Sample records for hiv early aging

  1. Synaptic plasticity in early aging.

    E-Print Network [OSTI]

    Lynch, Gary; Rex, Christopher S; Gall, Christine M

    2006-01-01

    life-span. Neurobiol. Aging 26, 511–520. Aicardi, G. ,patterns of mammalian brain aging: distribution of cathepsinand dystrophic dendrites in aging dogs resembles that in

  2. MATHEMATICAL ANALYSIS OF AGE-STRUCTURED HIV-1 ...

    E-Print Network [OSTI]

    SIAM (#1) 1035 2001 Apr 10 12:32:38

    2007-02-27

    tion to describe a continuous delay between infection and viral production and found no change in the .... function ?(a) (0 ? ?(a) ? 1) that describes the proportion of infected cells that have ...... The management of HIV-infected patients ...

  3. HIV evolution in early infection: selection pressures, patterns...

    Office of Scientific and Technical Information (OSTI)

    host environment and immune responses typically experienced by the newly transmitted virus. For example, sites that tend to evolve rapidly across multiple early-infection...

  4. Bronze metallurgy in Iron Age central Europe : a metallurgical study of Early Iron Age bronzes from Sti?na, Slovenia.

    E-Print Network [OSTI]

    Cooney, Elizabeth Myers

    2007-01-01

    The Early Iron Age (750-450 BCE) marks a time in the European Alpine Region in which cultural ideologies surrounding bronze objects and bronze production were changing. Iron was becoming the preferred material from which ...

  5. The Early Formation, Evolution and Age of the Neutron-Capture Elements in the Early Galaxy

    E-Print Network [OSTI]

    J. J. Cowan; C. Sneden; J. W. Truran

    2001-03-14

    Abundance observations indicate the presence of rapid-neutron capture (i.e., r-process) elements in old Galactic halo and globular cluster stars. These observations demonstrate that the earliest generations of stars in the Galaxy, responsible for neutron-capture synthesis and the progenitors of the halo stars, were rapidly evolving. Abundance comparisons among several halo stars show that the heaviest neutron-capture elements (including Ba and heavier) are consistent with a scaled solar system r-process abundance distribution, while the lighter such elements do not conform to the solar pattern. These comparisons suggest two r-process sites or at least two different sets of astrophysical conditions. The large star-to-star scatter observed in the neutron-capture/iron ratios at low metallicities -- which disappears with increasing [Fe/H] -- suggests an early, chemically unmixed and inhomogeneous Galaxy. The stellar abundances indicate a change from the r-process to the slow neutron capture (i.e., s-) process at higher metallicities in the Galaxy. The detection of thorium in halo and globular cluster stars offers a promising, independent age-dating technique that can put lower limits on the age of the Galaxy.

  6. Guang Ye, Characterization of cement paste at early age, 1 of 11 Fax: +31 15 2785895

    E-Print Network [OSTI]

    Guang Ye, Characterization of cement paste at early age, 1 of 11 Fax: +31 15 2785895 E-mail: ye.guang@ct.tudelft.nl A MICROMECHANIC MODEL FOR CHARACTERIZATION OF CEMENT PASTE AT EARLY AGE VALIDATED WITH EXPERIMENTS Guang Ye Delft of a cement-based material, i.e. the stiffness of cement paste, is the result of the continuous change

  7. Neurocognitive impairment associated with predominantly early stage HIV infection in Abuja, Nigeria

    E-Print Network [OSTI]

    2014-01-01

    Okwuasaba : R. Adebiyi Institute of Human Virology-Nigeria,Abuja, Nigeria however, performed better than SN on theHIV infection in Abuja, Nigeria Christopher Akolo & Walter

  8. University of Wisconsin Milwaukee Baccalaureate Degree Early Childhood Education (Ages 0-8 certification)

    E-Print Network [OSTI]

    Saldin, Dilano

    University of Wisconsin ­ Milwaukee Baccalaureate Degree Early Childhood Education (Ages 0-8 certification) Wisconsin Technical College System A.A.S. Early Childhood Education Effective Date: For students Description and Rationale: Students completing the AAS degree in Early Childhood Education at one

  9. Prediction of early-age cracking of UHPC materials and structures : a thremo-chemo-mechanics approach

    E-Print Network [OSTI]

    Shim, JongMin, 1975-

    2005-01-01

    Ultra-High Performance Concrete [UHPC] has remarkable performance in mechanical properties, ductility, economical benefit, etc., but early-age cracking of UHPC can become an issue during the manufacturing process due to ...

  10. Atomic structure of Cu-10. 9 at % Be alloys in the early stages of aging

    SciTech Connect (OSTI)

    Koo, Y.M.

    1987-01-01

    Diffuse x-ray scattering was employed to investigate the local atomic structure and static strains in a single crystal of a Cu-10.9 at. % Be alloy in the early stages of aging. In addition to these experiments, neutron elastic and inelastic scattering were obtained to investigate the phonon properties in the as-quenched state of this alloy. In the as-quenched state, there is a nearly regular array of small ellipsoidal Be clusters aligned along <100> directions (This produces the tweed contrast seen in TEM). The density of these clusters is 7.5 x 10/sup 26//m/sup 3/. The diffuse streaks seen in electron diffraction patterns are due largely to thermal diffuse scattering. Phonon-dispersion curves show no large differences from those of pure copper, except at (xi xi xi)/sub T/ zone boundary, where there is softening. This difference may be due to a Kohn anomaly. The elastic anisotropy of this alloy increases considerably with alloying, which probably leads to the plate-like GP zone morphology in subsequent aging treatments. The structure of the GP zones is a mixture of Be-rich single- and multi-layered zones. As aging proceeds, the zones grow in thickness.

  11. Reconstructing the Cosmic Evolution of Quasars from the Age Distribution of Local Early-Type Galaxies

    E-Print Network [OSTI]

    Zoltan Haiman; Raul Jimenez; Mariangela Bernardi

    2006-10-24

    We use the spectra of 22,000 nearby early-type galaxies from the Sloan Digital Sky Survey (SDSS) to determine the age distribution of these galaxies as a function of their velocity dispersion sigma_v in the range 100 km/s at fixed sigma_v. These assumptions require that the SMBH remnants of quasars with bolometric luminosity below L_bol=10^{12.5} f_Edd L_sun reside predominantly in bulges of late type galaxies. We find that evolution of the observed quasar LF can be fit over the entire redshift range in this simple model, 0=0.3-0.5. We find no evidence that any of the model parameters evolves with redshift, supporting the strong connection between the formation of stars and nuclear SMBHs in spheroids.

  12. Influence of Cement Particle-Size Distribution on Early Age Autogenous Strains and Stresses in Cement-Based Materials

    E-Print Network [OSTI]

    Bentz, Dale P.

    Influence of Cement Particle-Size Distribution on Early Age Autogenous Strains and Stresses in Cement-Based Materials Dale P. Bentz* Building and Fire Research Laboratory, National Institute-Jochen Haecker* Wilhelm Dyckerhoff Institut, 65203 Wiesbaden, Germany The influence of cement particle

  13. Early Jurassic shale chemostratigraphy and UPb ages from the Neuqun Basin (Argentina): Implications for the Toarcian Oceanic Anoxic Event

    E-Print Network [OSTI]

    Svensen, Henrik

    Early Jurassic shale chemostratigraphy and U­Pb ages from the Neuquén Basin (Argentina, Argentina c Department of Geosciences, University of Oslo, PO Box 1047 Blindern, 0316 Oslo, Norway d shale section in the Neuquén Basin, Argentina, are presented in order to better constrain the triggering

  14. Mechanisms of Mating-Behavior Deterioration in Early Aging Male C. elegans 

    E-Print Network [OSTI]

    Guo, Xiaoyan

    2014-08-06

    adulthood, as the mating potency of 3-day-old wild-type males is significantly lower than 1-day-old males. Meanwhile, using both pharmacological tests and calcium imaging, I showed that the excitability of the mating circuit increased during early adulthood...

  15. Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female Aging and

    E-Print Network [OSTI]

    Brinton, Roberta Diaz

    Early Decline in Glucose Transport and Metabolism Precedes Shift to Ketogenic System in Female and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, United States of America, 2 Department of Neurology, Keck School of Medicine, University of Southern California

  16. ASCE Journal of Materials in Civil Engineering, 20 (7), 502-508, 2008. Early-Age Properties of Cement-Based Materials: I. Influence of Cement Fineness

    E-Print Network [OSTI]

    Bentz, Dale P.

    of Cement-Based Materials: I. Influence of Cement Fineness Dale P. Bentz1* , Gaurav Sant1 , and Jason Weiss1 Abstract The influence of cement fineness on early-age properties of cement-based materials is investigated deformation. Measurements of these properties for two cements of widely different fineness are supplemented

  17. The Chachil Limestone (Pliensbachianeearliest Toarcian) Neuqun Basin, Argentina: UePb age calibration and its significance on the Early Jurassic

    E-Print Network [OSTI]

    Galland, Olivier

    The Chachil Limestone (Pliensbachianeearliest Toarcian) Neuquén Basin, Argentina: UePb age Geológico Minero Argentino and CONICET, Av. Julio A. Roca 651, 1322 Buenos Aires, Argentina b Physics Geológicas, Universidad Nacional de la Plata, Calle 1 - # 644, 1900 La Plata, Argentina e Volcanic Basin

  18. ASCE Journal of Materials in Civil Engineering, 21 (9), 512-517, 2009. Early-Age Properties of Cement-Based Materials: II. Influence of Water-to-Cement Ratio

    E-Print Network [OSTI]

    Bentz, Dale P.

    potentially be major contributors to early-age cracking of cement-based materials (ACI 2008). This paper of Standards and Technology, 100 Bureau Dr. Stop 8615, Gaithersburg, MD 20899 (301)975-5865, FAX: (301 Institute of Standards and Technology, 100 Bureau Dr. Stop 8615, Gaithersburg, MD 20899 (301)975-3175, E

  19. Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease

    E-Print Network [OSTI]

    Lowe, Xiu R

    2009-01-01

    Early brain response to low-dose radiation exposure involvesRunning Title: Low dose radiation affects cognitive functionEarly brain response to low-dose radiation exposure involves

  20. Post-treatment control of HIV infection

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Conway, Jessica M.; Perelson, Alan S.

    2015-04-13

    Antiretroviral therapy (ART) for HIV is not a cure. However, recent studies suggest that ART, initiated early during primary infection, may induce post-treatment control (PTC) of HIV infection with HIV RNA maintained at more »cells, virus, and cytotoxic T lymphocytes (CTLs). Analysis of our model reveals a range in CTL response strengths where a patient may show either VR or PTC, depending on the size of the latent reservoir at treatment termination. Below this range, patients will always rebound, whereas above this range, patients are predicted to behave like elite controllers. As a result, using data on latent reservoir sizes in patients treated during primary infection, we also predict population-level VR times for non-controllers consistent with observations.« less

  1. Chancellor's Memorandum CM-25 LSUHSC Policy on AIDS (HIV) and Hepatitis Virus (HBV)

    E-Print Network [OSTI]

    Chancellor's Memorandum CM-25 ­ LSUHSC Policy on AIDS (HIV) and Hepatitis Virus (HBV) To: Vice Orleans Chancellor May 15, 2002 Individuals Infected with Human Immunodeficiency Virus (HIV)/Hepatitis B Virus (HBV)/Hepatitis C Virus (HCV) It is a policy of LSUHSC to encourage preventive and early care

  2. HIV Sequence Compendium 2010

    SciTech Connect (OSTI)

    Kuiken, Carla; Foley, Brian; Leitner, Thomas; Apetrei, Christian; Hahn, Beatrice; Mizrachi, Ilene; Mullins, James; Rambaut, Andrew; Wolinsky, Steven; Korber, Bette

    2010-12-31

    This compendium is an annual printed summary of the data contained in the HIV sequence database. In these compendia we try to present a judicious selection of the data in such a way that it is of maximum utility to HIV researchers. Each of the alignments attempts to display the genetic variability within the different species, groups and subtypes of the virus. This compendium contains sequences published before January 1, 2010. Hence, though it is called the 2010 Compendium, its contents correspond to the 2009 curated alignments on our website. The number of sequences in the HIV database is still increasing exponentially. In total, at the time of printing, there were 339,306 sequences in the HIV Sequence Database, an increase of 45% since last year. The number of near complete genomes (>7000 nucleotides) increased to 2576 by end of 2009, reflecting a smaller increase than in previous years. However, as in previous years, the compendium alignments contain only a small fraction of these. Included in the alignments are a small number of sequences representing each of the subtypes and the more prevalent circulating recombinant forms (CRFs) such as 01 and 02, as well as a few outgroup sequences (group O and N and SIV-CPZ). Of the rarer CRFs we included one representative each. A more complete version of all alignments is available on our website, http://www.hiv.lanl.gov/content/sequence/NEWALIGN/align.html. Reprints are available from our website in the form of both HTML and PDF files. As always, we are open to complaints and suggestions for improvement. Inquiries and comments regarding the compendium should be addressed to seq-info@lanl.gov.

  3. HIV-1 intracellular immunization via HIV-1 derived vector delivered genetic mechanisms

    E-Print Network [OSTI]

    Swan, Christina Heidi

    2006-01-01

    long-term engraftment of NOD/SCID mice by HIV vectors.long-term engraftment of NOD/SCID mice by HIV vectors.HIV-1 infection in NOD/SCID-hu thy/liv thymocytes …………… 38

  4. HIV-1 intracellular immunization via HIV-1 derived vector delivered genetic mechanisms

    E-Print Network [OSTI]

    Swan, Christina Heidi

    2006-01-01

    stimulate DC-SIGN-mediated HIV transmission. Virology 2004;DC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmissionDC-SIGN-mediated infectious synapse formation enhances X4 HIV-1 transmission

  5. Early Space Age! Launch Vehicle Dynamics!

    E-Print Network [OSTI]

    Stengel, Robert F.

    .3! Political Rains and First Fruit: The Cold War and Sputnik! 2! #12;German Vengeance (Aggregate) Weapons" http" Trajectory" 7! Nuclear Weapons and the Balance of Power" "Enola Gay" B-29" "Fat Man" Atomic Bomb" "Little Boy), Research Board for National Security" !! R&D without politics ­ good idea?" !! 1944: Henry Smyth (Princeton)

  6. Labor Market Returns to Early Childhood Stimulation: a 20-year Followup to an Experimental Intervention in Jamaica

    E-Print Network [OSTI]

    2013-01-01

    School-based early childhood education and age-28 well-Johnson (2002). Early childhood education: Young adultduring early childhood on education among Guatemalan adults.

  7. Labor Market Returns to Early Childhood Stimulation: A 20-year Followup to an Experimental Intervention in Jamaica

    E-Print Network [OSTI]

    2013-01-01

    Johnson (2002). Early childhood education: Young adultSchool-based early childhood education and age-28 well-during early childhood on education among Guatemalan adults.

  8. Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool during Effective HIV Therapy

    E-Print Network [OSTI]

    2015-01-01

    Persistent HIV Type 1 DNA Pool During Effective HIV Therapyconstant HIV-1 DNA integrant pool that was geneticallydata on the change in the pool of HIV-1–integrated memory T

  9. HIV Surveillance in a Large, Community-Based Study: Results from the Pilot Study of Project Accept (HIV Prevention Trials Network 043)

    E-Print Network [OSTI]

    2011-01-01

    were discordant, and HIV POS if the first two tests were2 (0.63%) of 317 HIV POS samples were HIV-negative; 2 (8.3%)participants were designated HIV POS. If one of the two HIV

  10. NORTHERN ILLINOIS UNIVERSITY Early Childhood Studies

    E-Print Network [OSTI]

    Karonis, Nicholas T.

    , and other professionals involved in the education and care of young children. The Early Childhood Studies and Goals "Early childhood education is a diverse field encompassing a broad age-range of the lifespan1 NORTHERN ILLINOIS UNIVERSITY Early Childhood Studies Policies and Program Information: A Handbook

  11. Integrated Geochronologic, Geochemical, and Sedimentological Investigation of Proterozoic-Early Paleozoic Strata: From Northern India to Global Perspectives

    E-Print Network [OSTI]

    McKenzie, Neil Ryan

    2012-01-01

    Supergroup,  India:  age,  diagenesis,  correlations  and  during  very  early  diagenesis  (Bengtson   et  al. ,  

  12. MATHEMATICAL ANALYSIS OF AGE-STRUCTURED HIV-1 ...

    E-Print Network [OSTI]

    SIAM (#1) 1035 2001 Apr 10 12:32:38

    2007-08-22

    therapies involving reverse transcriptase, protease, and entry/fusion inhibitors. ... the U.S. Department of Energy under contract DE-AC52-06NA25396. The U.S. ...

  13. Causal Inference Methods and Their Application To HIV Observational Study Data

    E-Print Network [OSTI]

    Anglemyer, Andrew Thomas

    2010-01-01

    based clinics. Study nurses visited pediatric HIV clinicsbased clinics. Study nurses visited pediatric HIV clinics

  14. Aging gauge

    DOE Patents [OSTI]

    Betts, Robert E. (Huntsville, AL); Crawford, John F. (Huntsville, AL)

    1989-01-01

    An aging gauge comprising a container having a fixed or a variable sized t opening with a cap which can be opened to control the sublimation rate of a thermally sublimational material contained within the container. In use, the aging gauge is stored with an item to determine total heat the item is subjected to and also the maximum temperature to which the item has been exposed. The aging gauge container contains a thermally sublimational material such as naphthalene or similar material which has a low sublimation rate over the temperature range from about 70.degree. F. to about 160.degree. F. The aging products determined by analyses of a like item aged along with the aging gauge for which the sublimation amount is determined is employed to establish a calibration curve for future aging evaluation. The aging gauge is provided with a means for determining the maximum temperature exposure (i.e., a thermally indicating material which gives an irreversible color change, Thermocolor pigment). Because of the relationship of doubling reaction rates for increases of 10.degree. C., equivalency of item used in accelerated aging evaluation can be obtained by referring to a calibration curve depicting storage temperature on the abscissa scale and multiplier on the ordinate scale.

  15. AGING GAUGE

    DOE Patents [OSTI]

    Betts, Robert E.; Crawford, John F.

    1989-04-04

    An aging gauge comprising a container having a fixed or a variable sized t opening with a cap which can be opened to control the sublimation rate of a thermally sublimational material contained within the container. In use, the aging gauge is stored with an item to determine total heat the item is subjected to and also the maximum temperature to which the item has been exposed. The aging gauge container contains a thermally sublimational material such as naphthalene or similar material which has a low sublimation rate over the temperature range from about 70.degree. F. to about 160.degree. F. The aging products determined by analyses of a like item aged along with the aging gauge for which the sublimation amount is determined is employed to establish a calibration curve for future aging evaluation. The aging gauge is provided with a means for determining the maximum temperature exposure (i.e., a thermally indicating material which gives an irreversible color change, Thermocolor pigment). Because of the relationship of doubling reaction rates for increases of 10.degree. C., equivalency of item used in accelerated aging evaluation can be obtained by referring to a calibration curve depicting storage temperature on the abscissa scale and multiplier on the ordinate scale.

  16. The Aging Brain: Are two pathologies worse than one? White matter hyperintensities, beta-amyloid, and cognition in normal elderly

    E-Print Network [OSTI]

    Onami, Susan

    2010-01-01

    related with cognition in aging and early Alzheimer disease,is normal, Neurobiology of Aging, 26.4, 9. Jeerakathil, T. ,related with cognition in aging and early Alzheimer disease,

  17. Emergence of recombinant forms in geographic regions with co-circulating HIV subtypes in the dynamic HIV-1 epidemic

    SciTech Connect (OSTI)

    Zhang, Ming; Letiner, Thomas K; Korber, Bette T; Foley, Brian

    2009-01-01

    We have reexamined the subtype designations of {approx}10,000 subtype A, B, C, G, and AG, BC, BF recombinant sequences, and compared the results of the new analysis with their published designations. Intersubtype recombinants dominate HIV epidemics in three different geographical regions. The circulating recombinant from (CRF) CRF02-AG, common in West Central Africa, appears to result from a recombination event that occurred early in the divergence between subtypes A and G, although additional more recent recombination events may have contributed to the breakpoint pattern in this recombinant lineage as well. The Chinese recombinant epidemic strains CRF07 and CRF08, in contrast, result from recent recombinations between more contemporary strains. Nevertheless, CRF07 and CRF08 contributed to many subsequent recombination events. The BF recombinant epidemics in two HIV-1 epicenters in South America are not independent and BF epidemics in South America have an unusually high fraction of unique recombinant forms (URFs) that have each been found only once and carry distinctive breakpoints. Taken together, these analyses reveal a complex and dynamic picture of the current HIV-1 epidemic, and suggest a means of grouping and tracking relationships between viruses through preservation of shared breakpints.

  18. HIV classification using coalescent theory

    SciTech Connect (OSTI)

    Zhang, Ming; Letiner, Thomas K; Korber, Bette T

    2008-01-01

    Algorithms for subtype classification and breakpoint detection of HIV-I sequences are based on a classification system of HIV-l. Hence, their quality highly depend on this system. Due to the history of creation of the current HIV-I nomenclature, the current one contains inconsistencies like: The phylogenetic distance between the subtype B and D is remarkably small compared with other pairs of subtypes. In fact, it is more like the distance of a pair of subsubtypes Robertson et al. (2000); Subtypes E and I do not exist any more since they were discovered to be composed of recombinants Robertson et al. (2000); It is currently discussed whether -- instead of CRF02 being a recombinant of subtype A and G -- subtype G should be designated as a circulating recombination form (CRF) nd CRF02 as a subtype Abecasis et al. (2007); There are 8 complete and over 400 partial HIV genomes in the LANL-database which belong neither to a subtype nor to a CRF (denoted by U). Moreover, the current classification system is somehow arbitrary like all complex classification systems that were created manually. To this end, it is desirable to deduce the classification system of HIV systematically by an algorithm. Of course, this problem is not restricted to HIV, but applies to all fast mutating and recombining viruses. Our work addresses the simpler subproblem to score classifications of given input sequences of some virus species (classification denotes a partition of the input sequences in several subtypes and CRFs). To this end, we reconstruct ancestral recombination graphs (ARG) of the input sequences under restrictions determined by the given classification. These restritions are imposed in order to ensure that the reconstructed ARGs do not contradict the classification under consideration. Then, we find the ARG with maximal probability by means of Markov Chain Monte Carlo methods. The probability of the most probable ARG is interpreted as a score for the classification. To our knowledge, this particular problem was not addressed up to now. The software package Lamarc Kuhner et al. (2000) allows for sampling ARGs, but it assumes that recombination events only involve one breakpoint. However, in HIV recombinants usually have more than one breakpoint. Moreover, Lamarc does not perform an explicit breakpoint detection, but tries to find them by chance. Although this approach is suitable for most situations, it will not lead to satisfying results in case of highly recombining viruses with multiple breakpoints.

  19. Early photons from the early universe

    E-Print Network [OSTI]

    Trimble, V; Trimble, V

    2006-01-01

    locate/newastrev Early photons from the early universevery far through such a photon sea. This remains, of course,

  20. Relative Ages of Globular Clusters

    E-Print Network [OSTI]

    Thomas H. Puzia

    2002-10-18

    Ages of extragalactic globular clusters can provide valuable insights into the formation and evolution of galaxies. In this contribution the photometric methods of age dating old globular cluster systems are summarised. The spectroscopic approach is reviewed with an emphasis of the right choice of age diagnostics. We present a new method of quantifying the relatively best age-sensitive spectroscopic index given the quality of a data set and a certain theoretical stellar synthesis model. The relatively best diagnostic plot is constructed from the set of Lick indices and used to age date globular clusters in several early-type galaxies which are part of a large spectroscopic survey of extragalactic globular cluster systems. We find that, independently of host galaxy, metal-poor ([Fe/H] 8 Gyr) and coeval. Metal-rich clusters show a wide range of ages from ~15 down to a few Gyr.

  1. Research Review: Recent Progress in HIV Entry Inhibition

    E-Print Network [OSTI]

    Fisher, Craig

    2013-01-01

    co-maleic acid) against HIV-1. PSM acts to inhibit HIV cellbinding site located on gp120. PSM shows low cytotoxicity,

  2. HIV virus spread and evolution studied through computer modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HIV and evolution studied through computer modeling HIV virus spread and evolution studied through computer modeling This approach distinguishes between susceptible and infected...

  3. Earth: The Early Years We discuss ...

    E-Print Network [OSTI]

    Earth: The Early Years We discuss ... · What happened to the Earth during the first few billion)? · What is the relationship to (early) life? #12;Age of Earth James Ussher (17th C) biblical account: 6: 20-40 m.y. (million years!) Charles Darwin evolution >300 m.y. Lord Kelvin (1880's) cooling Earth: 50

  4. HIV transcription is induced in dying cells

    SciTech Connect (OSTI)

    Woloschak, G.E.; Chang-Liu, Chin-Mei; Schreck, S. |; Panozzo, J.; Libertin, C.R.

    1996-02-01

    Using HeLa cells stably transfected with an HIV-LTR-CAT construct, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires functional p53, which is not present in HeLa cells. For all other agents, HIV-LTR induction was dose-dependent and correlated with the amount of cell killing that occurred in the culture. Doses which caused over 99% cell killing induced HIV-LTR transcription maximally, demonstrating that cells that will go on to die by 14 days are the cells expressing HIV-LTR-CAT.

  5. HIV-1 transmission linkage in an HIV-1 prevention clinical trial

    SciTech Connect (OSTI)

    Leitner, Thomas; Campbell, Mary S; Mullins, James I; Hughes, James P; Wong, Kim G; Raugi, Dana N; Scrensen, Stefanie

    2009-01-01

    HIV-1 sequencing has been used extensively in epidemiologic and forensic studies to investigate patterns of HIV-1 transmission. However, the criteria for establishing genetic linkage between HIV-1 strains in HIV-1 prevention trials have not been formalized. The Partners in Prevention HSV/HIV Transmission Study (ClinicaITrials.gov NCT00194519) enrolled 3408 HIV-1 serodiscordant heterosexual African couples to determine the efficacy of genital herpes suppression with acyclovir in reducing HIV-1 transmission. The trial analysis required laboratory confirmation of HIV-1 linkage between enrolled partners in couples in which seroconversion occurred. Here we describe the process and results from HIV-1 sequencing studies used to perform transmission linkage determination in this clinical trial. Consensus Sanger sequencing of env (C2-V3-C3) and gag (p17-p24) genes was performed on plasma HIV-1 RNA from both partners within 3 months of seroconversion; env single molecule or pyrosequencing was also performed in some cases. For linkage, we required monophyletic clustering between HIV-1 sequences in the transmitting and seroconverting partners, and developed a Bayesian algorithm using genetic distances to evaluate the posterior probability of linkage of participants sequences. Adjudicators classified transmissions as linked, unlinked, or indeterminate. Among 151 seroconversion events, we found 108 (71.5%) linked, 40 (26.5%) unlinked, and 3 (2.0%) to have indeterminate transmissions. Nine (8.3%) were linked by consensus gag sequencing only and 8 (7.4%) required deep sequencing of env. In this first use of HIV-1 sequencing to establish endpoints in a large clinical trial, more than one-fourth of transmissions were unlinked to the enrolled partner, illustrating the relevance of these methods in the design of future HIV-1 prevention trials in serodiscordant couples. A hierarchy of sequencing techniques, analysis methods, and expert adjudication contributed to the linkage determination process.

  6. Brain Imaging and Neurodevelopment in HIV-uninfected Thai Children Born to HIV-infected Mothers

    E-Print Network [OSTI]

    2015-01-01

    to HIV- Infected Mothers D Neda Jahanshad, PhD 1* , Marie-C EP Corresponding author: Neda Jahanshad PhD, Assistant

  7. Design Evolution Study - Aging Options

    SciTech Connect (OSTI)

    P. McDaniel

    2002-04-05

    The purpose of this study is to identify options and issues for aging commercial spent nuclear fuel received for disposal at the Yucca Mountain Mined Geologic Repository. Some early shipments of commercial spent nuclear fuel to the repository may be received with high-heat-output (younger) fuel assemblies that will need to be managed to meet thermal goals for emplacement. The capability to age as much as 40,000 metric tons of heavy metal of commercial spent nuclear he1 would provide more flexibility in the design to manage this younger fuel and to decouple waste receipt and waste emplacement. The following potential aging location options are evaluated: (1) Surface aging at four locations near the North Portal; (2) Subsurface aging in the permanent emplacement drifts; and (3) Subsurface aging in a new subsurface area. The following aging container options are evaluated: (1) Complete Waste Package; (2) Stainless Steel inner liner of the waste package; (3) Dual Purpose Canisters; (4) Multi-Purpose Canisters; and (5) New disposable canister for uncanistered commercial spent nuclear fuel. Each option is compared to a ''Base Case,'' which is the expected normal waste packaging process without aging. A Value Engineering approach is used to score each option against nine technical criteria and rank the options. Open issues with each of the options and suggested future actions are also presented. Costs for aging containers and aging locations are evaluated separately. Capital costs are developed for direct costs and distributable field costs. To the extent practical, unit costs are presented. Indirect costs, operating costs, and total system life cycle costs will be evaluated outside of this study. Three recommendations for aging commercial spent nuclear fuel--subsurface, surface, and combined surface and subsurface are presented for further review in the overall design re-evaluation effort. Options that were evaluated but not recommended are: subsurface aging in a new subsurface area (high cost); surface aging in the complete waste package (risk to the waste package and impact on the Waste Handling Facility); and aging in the stainless steel liner (impact on the waste package design and new high risk operations added to the waste packaging process). The selection of a design basis for aging will be made in conjunction with the other design re-evaluation studies.

  8. Early photons from the early universe

    E-Print Network [OSTI]

    Trimble, V; Trimble, V

    2006-01-01

    he addressed only helium production (?nding an answer notmodern calculation of helium production in the early uni-

  9. Aging in American Convents

    E-Print Network [OSTI]

    Corwin, Anna I.

    2009-01-01

    Schuster. Snowdon, David 2001 Aging with Grace: What the Nunreligion, devotion, and aging. CSW JAN09 update tocAging in American Convents FIELDWORK REPORT by Anna I.

  10. Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins

    DOE Patents [OSTI]

    Korber, Bette T. (Los Alamos, NM); Perkins, Simon (Los Alamos, NM); Bhattacharya, Tanmoy (Los Alamos, NM); Fischer, William M. (Los Alamos, NM); Theiler, James (Los Alamos, NM); Letvin, Norman (Boston, MA); Haynes, Barton F. (Durham, NC); Hahn, Beatrice H. (Birmingham, AL); Yusim, Karina (Los Alamos, NM); Kuiken, Carla (Los Alamos, NM)

    2012-02-21

    The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

  11. HIV Testing, Tuberculosis, and AIDS Stigma in Kampala, Uganda

    E-Print Network [OSTI]

    Singer, Samuel J

    2008-01-01

    503. Ministry of Health and ORC Macro (2006). Uganda HIV/Maryland, Minstry of Health and ORC Macro,. Monico, S.M. ,rates (Ministry of Health and ORC Macro 2006). HIV sentinel

  12. Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection

    E-Print Network [OSTI]

    Archary, Derseree

    Neutralizing (nAbs) and high affinity binding antibodies may be critical for an efficacious HIV-1 vaccine. We characterized virus-specific nAbs and binding antibody responses over 21 months in eight HIV-1 subtype C chronically ...

  13. Quantification of the epitope diversity of HIV-1-specific binding antibodies by peptide microarrays for global HIV-1 vaccine development

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Stephenson, Kathryn E.; Neubauer, George H.; Reimer, Ulf; Pawlowski, Nikolaus; Knaute, Tobias; Zerweck, Johannes; Korber, Bette T.; Barouch, Dan H.

    2014-11-14

    An effective vaccine against human immunodeficiency virus type 1 (HIV-1) will have to provide protection against a vast array of different HIV-1 strains. Current methods to measure HIV-1-specific binding antibodies following immunization typically focus on determining the magnitude of antibody responses, but the epitope diversity of antibody responses has remained largely unexplored. Here we describe the development of a global HIV-1 peptide microarray that contains 6564 peptides from across the HIV-1 proteome and covers the majority of HIV-1 sequences in the Los Alamos National Laboratory global HIV-1 sequence database. Using this microarray, we quantified the magnitude, breadth, and depth ofmore »IgG binding to linear HIV-1 sequences in HIV-1-infected humans and HIV-1-vaccinated humans, rhesus monkeys and guinea pigs. The microarray measured potentially important differences in antibody epitope diversity, particularly regarding the depth of epitope variants recognized at each binding site. Our data suggest that the global HIV-1 peptide microarray may be a useful tool for both preclinical and clinical HIV-1 research.« less

  14. Early Childhood Education Report

    E-Print Network [OSTI]

    Toronto, University of

    Early Childhood Education Report 2014 #12;Early Childhood Education Report 2014 is published by in Education holds the copyright to the Early Childhood Education Report 2014. It encourages digital or hard: Akbari, E., McCuaig, K. (2014) Early Childhood Education Report 2014. Toronto: Ontario Institute

  15. Furman University's Early Childhood

    E-Print Network [OSTI]

    Furman University's Early Childhood Education Graduate Studies in Education .furman.edu/gradstudies> Early Childhood Education Designed to add endorsement in early childhood to a teaching certificate abilities. Faculty Lorraine DeJong, Ph.D. Early Childhood Education coordinator and main professor Judy

  16. Quantifying factors determining the rate of CTL escape and reversion during acute and chronic phases of HIV infection

    SciTech Connect (OSTI)

    Ganusov, Vitaly V [Los Alamos National Laboratory; Korber, Bette M [Los Alamos National Laboratory; Perelson, Alan S [Los Alamos National Laboratory

    2009-01-01

    Human immunodeficiency virus (HIV) often evades cytotoxic T cell (CTL) responses by generating variants that are not recognized by CTLs. However, the importance and quantitative details of CTL escape in humans are poorly understood. In part, this is because most studies looking at escape of HIV from CTL responses are cross-sectional and are limited to early or chronic phases of the infection. We use a novel technique of single genome amplification (SGA) to identify longitudinal changes in the transmitted/founder virus from the establishment of infection to the viral set point at 1 year after the infection. We find that HIV escapes from virus-specific CTL responses as early as 30-50 days since the infection, and the rates of viral escapes during acute phase of the infection are much higher than was estimated in previous studies. However, even though with time virus acquires additional escape mutations, these late mutations accumulate at a slower rate. A poor correlation between the rate of CTL escape in a particular epitope and the magnitude of the epitope-specific CTL response suggests that the lower rate of late escapes is unlikely due to a low efficacy of the HIV-specific CTL responses in the chronic phase of the infection. Instead, our results suggest that late and slow escapes are likely to arise because of high fitness cost to the viral replication associated with such CTL escapes. Targeting epitopes in which virus escapes slowly or does not escape at all by CTL responses may, therefore, be a promising direction for the development of T cell based HIV vaccines.

  17. Early photons from the early universe

    E-Print Network [OSTI]

    Trimble, V; Trimble, V

    2006-01-01

    photons from the early universe Virginia Trimble Departmentradiation in an expanding universe will redshift to blackthe temperature of the universe,’’ (Kragh, 1996). And Alpher

  18. HIV transcription is induced in dying cells

    SciTech Connect (OSTI)

    Woloschak, G.E.; Chang-Liu, Chin-Mei; Schreck, S. |

    1995-06-01

    Using HeLa cells stably transfected with an HIV-LTR-CAT construct, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires functional p53, which is not present in HeLa cells. For all other agents, HIV-LTR induction was dose-dependent and correlated with the amount of cell killing that occurred in the culture. 14 refs., 4 figs., 1 tab.

  19. Early usage of DO in children with and without Specific Language Impairment

    E-Print Network [OSTI]

    Blossom, Megan Stratton

    2009-09-15

    This study examined the early uses of DO in the spontaneous language samples of 89 children, 37 with Specific Language Impairment, age 5;0-5;6, 37 age-equivalent control children, and 15 language-equivalent control children, ...

  20. Early age delamination in concrete pavements made with gravel aggregates 

    E-Print Network [OSTI]

    Liu, Juanyu

    2009-06-02

    ........................................................................................................165 6.32 Moisture profiles of test section 2....................................................................166 6.33 Evaporation rate of concrete at 24 hours..........................................................167 6.34 Free shrinkage... with time for different sections................................................168 6.35 Maximum free shrinkage of concrete...............................................................169 6.36 Main effects plot for maximum free shrinkage...

  1. Neuroimaging of Discourse Processing in Aging and Alzheimer's Disease

    E-Print Network [OSTI]

    Wang, Clarice

    2011-12-31

    Detection of very early stages of Alzheimer's Disease (AD) has been an area of difficulty for researchers due to confounds with age. Prose recall has been suggested as a diagnostically sensitive test of episodic memory declines in AD; however...

  2. Thoughts on Aging

    E-Print Network [OSTI]

    Feher, George

    2010-01-01

    The impetus of writing about aging came the other day afterMagnetic Resonance Thoughts on Aging George Feher Received:at Springerlink.com When we, aging scientists, fade away and

  3. Early Hominin Paleoecology Paleoecology

    E-Print Network [OSTI]

    Jones, Peter JS

    Early Hominin Paleoecology #12;#12;Early Hominin Paleoecology Matt Sponheimer, Julia A. Lee- orp Early hominin paleoecology / edited by Matt Sponheimer, Julia A. Lee- orp, Kaye E. Reed, and Peter Ungar - - - - (ebook) . Fossil hominids. . Paleoecology. . Paleontology. I. Sponheimer, Matt. GN .E . --dc Design

  4. Randomized Pilot Trial of a Synbiotic Dietary Supplement in Chronic HIV-1 Infection

    E-Print Network [OSTI]

    2012-01-01

    EM, Miura E: Use of probiotics in HIV-infected children: a1 (HIV-1), synbiotics, probiotics, prebiotics, microbialcomplement HAART. Pre- and probiotics are prime candidates

  5. HIV-AIDS Information Resources from the NLM - ACIO

    SciTech Connect (OSTI)

    Templin-Branner, W.

    2010-10-01

    As the treatment and management of HIV/AIDS continues to evolve with new scientific breakthroughs, treatment discoveries, and management challenges, it is difficult for people living with HIV/AIDS and those who care for them to keep up with the latest information on HIV/AIDS screening and testing, prevention, treatment, and research. The National Library of Medicine (NLM), of the National Institutes of Health, has a wealth of health information resources freely available on the Internet to address these needs.

  6. Mathematical Modeling of HIV-1 Infection and Drug Therapy

    E-Print Network [OSTI]

    2008-12-16

    standing of HIV-1 dynamics. Many important features of the interaction between virus particles and cells have been determined by fitting mathematical models to.

  7. Courses: Education: Curriculum and Teaching (EDCT) Page 295Sonoma State University 2010-2011 Catalog Education: Early Childhood Education (EDEC)

    E-Print Network [OSTI]

    Ravikumar, B.

    -2011 Catalog Education: Early Childhood Education (EDEC) edeC 239 intrOduCtiOn tO eArly ChildhOOd eduCAtiOn (3) Introduction to the theory and practice of early childhood education (from birth to age eight). Topics include: an overview of historical and contemporary models of early childhood education, principles of developmentally

  8. ORIGINAL PAPER Rates and Correlates of HIV and STI Infection

    E-Print Network [OSTI]

    Gelman, Andrew

    (&) Division of Clinical Phenomenology, New York State Psychiatric Institute, 1051, Riverside Drive, Unit 56ORIGINAL PAPER Rates and Correlates of HIV and STI Infection Among Homeless Women Carol L. M. Caton counterparts [1­3]. Moreover, mortality studies have demonstrated that HIV/ AIDS is a leading cause of death

  9. A High-Pressure Nano-imaging Breakthrough | Advanced Photon Source

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lead to Better Treatments for HIV, Early Aging The Superpower behind Iron Oxyfluoride Battery Electrodes Watching a Protein as it Functions Shedding Light on Chemistry with a...

  10. Early Childhood. Bachelor of Teaching

    E-Print Network [OSTI]

    Hickman, Mark

    Early Childhood. 2014 Bachelor of Teaching & Learning (Early Childhood) College of Education qualification for those starting out in Early Childhood teacher education. As well as gaining a teaching degree;3 Bachelor of Teaching and Learning (Early Childhood) The Bachelor of Teaching and Learning (Early Childhood

  11. A model of HIV budding and self-assembly, role of cell membrane

    E-Print Network [OSTI]

    Rui Zhang; Toan T. Nguyen

    2008-03-19

    Budding from the plasma membrane of the host cell is an indispensable step in the life cycle of the Human Immunodeficiency Virus (HIV), which belongs to a large family of enveloped RNA viruses, retroviruses. Unlike regular enveloped viruses, retrovirus budding happens {\\em concurrently} with the self-assembly of retrovirus protein subunits (Gags) into spherical virus capsids on the cell membrane. Led by this unique budding and assembly mechanism, we study the free energy profile of retrovirus budding, taking into account of the Gag-Gag attraction energy and the membrane elastic energy. We find that if the Gag-Gag attraction is strong, budding always proceeds to completion. During early stage of budding, the zenith angle of partial budded capsids, $\\alpha$, increases with time as $\\alpha \\propto t^{1/3}$. However, when Gag-Gag attraction is weak, a metastable state of partial budding appears. The zenith angle of these partially spherical capsids is given by $\\alpha_0\\simeq(\\tau^2/\\kappa\\sigma)^{1/4}$ in a linear approximation, where $\\kappa$ and $\\sigma$ are the bending modulus and the surface tension of the membrane, and $\\tau$ is a line tension of the capsid proportional to the strength of Gag-Gag attraction. Numerically, we find $\\alpha_0<0.3\\pi$ without any approximations. Using experimental parameters, we show that HIV budding and assembly always proceed to completion in normal biological conditions. On the other hand, by changing Gag-Gag interaction strength or membrane rigidity, it is relatively easy to tune it back and forth between complete budding and partial budding. Our model agrees reasonably well with experiments observing partial budding of retroviruses including HIV.

  12. Identification of full-length transmitted/founder viruses and their progeny in primary HIV-1 infection

    SciTech Connect (OSTI)

    Korber, Bette; Hraber, Peter; Giorgi, Elena; Bhattacharya, T

    2009-01-01

    Identification of transmitted/founder virus genomes and their progeny by is a novel strategy for probing the molecular basis of HIV-1 transmission and for evaluating the genetic imprint of viral and host factors that act to constrain or facilitate virus replication. Here, we show in a cohort of twelve acutely infected subjects (9 clade B; 3 clade C), that complete genomic sequences of transmitted/founder viruses could be inferred using single genome amplification of plasma viral RNA, direct amplicon sequencing, and a model of random virus evolution. This allowed for the precise identification, chemical synthesis, molecular cloning, and biological analysis of those viruses actually responsible for productive clinical infection and for a comprehensive mapping of sequential viral genomes and proteomes for mutations that are necessary or incidental to the establishment of HIV-1 persistence. Transmitted/founder viruses were CD4 and CCR5 tropic, replicated preferentially in activated primary T-Iymphocytes but not monocyte-derived macrophages, and were effectively shielded from most heterologous or broadly neutralizing antibodies. By 3 months of infection, the evolving viral quasispecies in three subjects showed mutational fixation at only 2-5 discreet genomic loci. By 6-12 months, mutational fixation was evident at 18-27 genomic loci. Some, but not all, of these mutations were attributable to virus escape from cytotoxic Tlymphocytes or neutralizing antibodies, suggesting that other viral or host factors may influence early HIV -1 fitness.

  13. HIV vaccine strategy expands immune responses

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (Journalvivo Low-Dose Lowï‚— WeUpdateScienceForTripHISTORY OF WEAKFeb.HIV

  14. New insights into HIV-1 vaccine design

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJessework usesofPublications64 2.251 2.211NewNew exhibitNew insights into HIV-1

  15. Bryan Early Political Science

    E-Print Network [OSTI]

    Alexandrova, Ivana

    Bryan Early Political Science Sponsor: U.S. Department of State Dates: May 1, 2014 to April 30/or trade, sometimes involving actors and destinations of proliferation concern. While both countries have

  16. Melatonin and the aging brain

    E-Print Network [OSTI]

    BONDY, S; SHARMAN, E

    2007-01-01

    mitochondrial decay of aging. Mol. Aspects Med. 26, Ames,the degenerative diseases of aging. Proc. Natl. Acad. Sci.2004. Retardation of brain aging by chronic treatment with

  17. Running Head: EMOTION AND AGING Emotion and Aging

    E-Print Network [OSTI]

    Mather, Mara

    Running Head: EMOTION AND AGING Emotion and Aging Mara Mather, M., & Ponzio, A. (in press). Emotion and aging. In L. Feldman Barrett, M. All of these basic mechanisms and contextual factors change in normal aging

  18. Parylene C Aging Studies.

    SciTech Connect (OSTI)

    Achyuthan, Komandoor; Sawyer, Patricia Sue.; Mata, Guillermo Adrian; White II, Gregory Von; Bernstein, Robert

    2014-09-01

    Parylene C is used in a device because of its conformable deposition and other advantages. Techniques to study Parylene C aging were developed, and %22lessons learned%22 that could be utilized for future studies are the result of this initial study. Differential Scanning Calorimetry yielded temperature ranges for Parylene C aging as well as post-deposition treatment. Post-deposition techniques are suggested to improve Parylene C performance. Sample preparation was critical to aging regimen. Short-term (~40 days) aging experiments with free standing and ceramic-supported Parylene C films highlighted %22lessons learned%22 which stressed further investigations in order to refine sample preparation (film thickness, single sided uniform coating, machine versus laser cutting, annealing time, temperature) and testing issues (%22necking%22) for robust accelerated aging of Parylene C.

  19. Assessing willingness to test for HIV among men who have sex with men using conjoint analysis, evidence for uptake of the FDA-approved at-home HIV test

    E-Print Network [OSTI]

    Lee, SJ; Brooks, R; Bolan, RK; Flynn, R

    2013-01-01

    are significant in light of the new at- home HIV test kitamong MSM. In light of the recently FDA-approved at-home HIV

  20. Emerging nanotechnology approaches for HIV/AIDS treatment and prevention

    E-Print Network [OSTI]

    von Andrian, Ulrich H.

    Emerging nanotechnology approaches for HIV/AIDS treatment and prevention The emergence of AIDS effects and is ineffective in patients in whom the virus develops resistance. Nanotechnology of nanotechnology to provide more effective treatment and preven

  1. The human gut microbiome : characterization challenges and HIV disease association

    E-Print Network [OSTI]

    Pérez Santiago, Josué; Pérez Santiago, Josué

    2012-01-01

    of ‘beneficial’ microbes. 4. Probiotics – live organismsof prebiotics and probiotics. 6. Th17 or T helpers 17E.M. & Miura, E. Use of probiotics in HIV-infected children:

  2. Decision making in the HIV/AIDS supply chain

    E-Print Network [OSTI]

    Cao, Elaine Phu

    2007-01-01

    During the first two decades of HIV/AIDS awareness, the U.S. and foreign governments responded slowly to the crisis. In contrast today, as the pandemic continues, initiatives of nonprofit organizations have dramatically ...

  3. Early Childhood Distance Partnership Program

    E-Print Network [OSTI]

    Lawrence, Rick L.

    the needs of Tribal Head Start/Early Childhood educators to complete a Bachelor Degree · Respond to national and Early Childhood Educators from six tribal communities to complete bachelor's degree in Early Childhood Education Enables ECEDP students to live and teach in their home communities Connects Native early childhood

  4. Early Childhood. Bachelor of Teaching

    E-Print Network [OSTI]

    Hickman, Mark

    Early Childhood. 2015 Bachelor of Teaching & Learning (Early Childhood) College of Education Education #12;Contents 3 Bachelor of Teaching and Learning (Early Childhood) 4 Entry Requirements starting out in Early Childhood teacher education. As well as gaining a teaching degree which qualifies

  5. An age-structured model for the coupled dynamics of HIV and HSV-2

    E-Print Network [OSTI]

    2014-12-24

    standing the invasion dynamics and biological interpretation of the expressions of the reproduction numbers. Sensitivity analysis is conducted to examine the.

  6. Aging and decision making 

    E-Print Network [OSTI]

    Miller, Sophie

    2010-06-30

    The study sought to clarify the effects of aging in regard to decision making abilities. Decision making is dependent upon the Frontal Cortex structures; the Orbitofrontal Cortex and the Dorsolateral Prefrontal Cortex. These structures are thought...

  7. Electrifying Vehicles Early Release

    E-Print Network [OSTI]

    Electrifying Vehicles Early Release Insights from the Canadian Plug-in Electric Vehicle Study #12;1 The Canadian Plug-in Electric Vehicle Study May 25 2015 Electric-mobility may be a key component-in electric vehicles will involve meaningful shifts in social and technical systems. This report considers

  8. Bryan Early Political Science

    E-Print Network [OSTI]

    Alexandrova, Ivana

    Bryan Early Political Science Sponsor: U.S. Department of State Dates: April 16, 2014 through April as an international border. Kosovo's political status is not yet fully resolved in the aftermath of its decision and illicit cargo magnify the risk that malicious actors could utilize Kosovo as a diversion point

  9. Affective Neuroscience of Aging The Affective Neuroscience of Aging

    E-Print Network [OSTI]

    Mather, Mara

    Affective Neuroscience of Aging - 1 - The Affective Neuroscience of Aging Mara Mather University running title: Affective Neuroscience of Aging #12;Affective Neuroscience of Aging - 2 - Contents INTRODUCTION THE FATE OF EMOTION-RELATED BRAIN REGIONS AND MONOAMINERGIC NEUROTRANSMITTER SYSTEMS IN AGING

  10. Women Who Know: The Relationship Between Gender, Risk, Race, and HIV Testing 

    E-Print Network [OSTI]

    Howden, Lindsay M.

    2010-07-14

    My main focus of interest in this dissertation is to evaluate the relationship between known risk factor for HIV and HIV testing behavior, with a particular interest in women. Utilizing data from the National Survey of ...

  11. Pilomatrical carcinoma: A case in a patient with HIV and hepatitis C

    E-Print Network [OSTI]

    Scheinfeld, Noah

    2008-01-01

    in a patient with HIV and hepatitis C Dermatology Onlinea 51-year-old man with HIV, hepatitis C, and pilomatricalCD4 count of 84, and hepatitis C with hepatic cirrhosis,

  12. The potential impact of male circumcision on HIV in sub-Saharan Africa

    E-Print Network [OSTI]

    2006-01-01

    controlled trials in Africa of HIV and AIDS: DescriptiveHIV infection in sub-Saharan Africa: A systematic review andepidemics in sub-Saharan Africa: Introduction. AIDS 15: S1–

  13. Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens

    DOE Patents [OSTI]

    Korber, Bette T. (Los Alamos, NM); Fischer, William (Los Alamos, NM); Liao, Hua-Xin (Durham, NC); Haynes, Barton F. (Durham, NC); Letvin, Norman (Boston, MA); Hahn; Beatrice H. (Birmingham, AL)

    2011-05-31

    The present invention relates to mosaic clade M HIV-1 Env polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

  14. Implementation of a Writing Intervention: Impact on Early Writing Development in Kindergarten and First Grade Writers 

    E-Print Network [OSTI]

    Cude, Kellie Carpenter

    2012-07-16

    Process writing research began with adult writers, eventually expanding to include school age children and more recently, emergent writers. Research at the early childhood level has often been directed at specific aspects ...

  15. A Narrative Examination of the Experience of Early Entrance to College 

    E-Print Network [OSTI]

    Kotinek, Jonathan David

    2013-07-05

    This study addresses the question “what is it like to be a gifted early college entrant?” Participants were eight college graduates between the ages of 23 and 45 who matriculated to college as full-time, degree-seeking ...

  16. Detrital geochronology and geochemistry of CretaceousEarly Miocene strata of Nepal: implications for timing and

    E-Print Network [OSTI]

    Najman, Yani

    Detrital geochronology and geochemistry of Cretaceous­Early Miocene strata of Nepal: implications terranes vary considerably in age and contain rocks that may yield geochronologic information, isotopic grains has proven valuable in geochronologic provenance studies because zircons are chemically stable

  17. HIV prevalence and awareness among wives of rural migrant workers of Muzaffarpur district in Bihar, India

    E-Print Network [OSTI]

    Ranjan, Alok

    2013-01-01

    the HIV prevalence statistics in India are mainly estimatedto males in India. As per the NACO statistics during 2009-

  18. HIV Fusion Peptide Penetrates, Disorders, and Softens T-Cell Membrane Mimics

    E-Print Network [OSTI]

    Nagle, John F.

    HIV Fusion Peptide Penetrates, Disorders, and Softens T-Cell Membrane Mimics Stephanie Tristram of N-terminal gp41 fusion peptide (FP) of human immunodeficiency virus type 1 (HIV-1) with model membranes in order to elucidate how FP leads to fusion of HIV and T-cell membranes. FP constructs were (i

  19. Inhibition of HIV-1 virus replication using small soluble Tat peptides Emmanuel Agbottah a

    E-Print Network [OSTI]

    Zeng, Chen

    Inhibition of HIV-1 virus replication using small soluble Tat peptides Emmanuel Agbottah inhibitor; Transcription; Cell cycle; Computer modeling; PBMC Introduction Human immunodeficiency virus (HIV not produce infectious virus (Garza and Carr, 1995). Tat not only stimulates the HIV long terminal repeat (LTR

  20. HIV-1 Fusion Peptide Decreases Bending Energy and Promotes Curved Fusion Intermediates

    E-Print Network [OSTI]

    Nagle, John F.

    HIV-1 Fusion Peptide Decreases Bending Energy and Promotes Curved Fusion Intermediates Stephanie in human immunodeficiency virus (HIV) infection is fusion between the viral envelope and the T x-ray scattering is that the bending modulus KC is greatly reduced upon addition of the HIV fusion

  1. Aging in fragile X syndrome

    E-Print Network [OSTI]

    2010-01-01

    intensified the need for aging studies in FXS. Approximatelywe have surveyed all of the aging patients with FXS that wemedical complications of aging seen in those with FXS. Data

  2. Signatures of aging

    SciTech Connect (OSTI)

    Cornwall, J.; Dyson, F.; Garwin, R.; Hammer, D.; Happer, W.; Lewis, N.; Schwitters, R.; Sullivan, J.; Williams, E.

    1998-01-06

    The Department of Energy and its three weapons laboratories (LANL, LLNL, and SNL) have developed a Stockpile Stewardship and Management Program (SSMP) in response to their designated mission of maintaining an effective, i.e. reliable and safe, nuclear deterrent without underground nuclear tests (UGTs). The need to ensure the effectiveness of an aging stockpile presents new challenges of major importance. In this study we review what is known about the aging of critical constituents, particularly the high explosives, polymers, and metals in the enduring stockpile. We discuss data that are required to provide a fuller understanding of aging, and how to obtain that data as a basis for anticipating and addressing potential stockpile problems. Our particular concern is problems that may arise in the short term, i.e. within the next 5 to 10 years, and their implied requirements for preventive maintenance and remanufacture.

  3. Counting Guns in Early America

    E-Print Network [OSTI]

    Lindgren, James

    2002-01-01

    Bang! Historian Explodes American Gun Myths, M INN . S TAR Tat 339-40 (1994). Counting Guns in Early America, Wm. & Maryto estimate levels of gun ownership in early America. This

  4. Early formation of evolved asteroidal crust James M. D. Day1

    E-Print Network [OSTI]

    Mcdonough, William F.

    granoblastic textures, 120u triple junctions between coexist- ing silicates, polysynthetic twinning-rich, with andesite bulk compositions. Their age of 4.52 6 0.06 Gyr demonstrates formation early in Solar System unrecognized diversity of early-formed materials in the Solar System. Formation of crust, the outermost solid

  5. The challenges of modelling antibody repertoire dynamics in HIV infection

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Luo, Shishi; Perelson, Alan S.

    2015-07-20

    Antibody affinity maturation by somatic hypermutation of B-cell immunoglobulin variable region genes has been studied for decades in various model systems using well-defined antigens. While much is known about the molecular details of the process, our understanding of the selective forces that generate affinity maturation are less well developed, particularly in the case of a co-evolving pathogen such as HIV. Despite this gap in understanding, high-throughput antibody sequence data are increasingly being collected to investigate the evolutionary trajectories of antibody lineages in HIV-infected individuals. Here, we review what is known in controlled experimental systems about the mechanisms underlying antibody selectionmore »and compare this to the observed temporal patterns of antibody evolution in HIV infection. In addition, we describe how our current understanding of antibody selection mechanisms leaves questions about antibody dynamics in HIV infection unanswered. Without a mechanistic understanding of antibody selection in the context of a co-evolving viral population, modelling and analysis of antibody sequences in HIV-infected individuals will be limited in their interpretation and predictive ability.« less

  6. Early Education Services Family Handbook

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    Early Education Services Family Handbook A Partnership in Caring Effective February 2014 Early Education Services University of California at Santa Cruz 599 Koshland Way Santa Cruz, CA 95064 (831) 459-2967 earlyeducation@ucsc.edu #12;2 Early Education Services Phone Numbers earlyeducation

  7. Diverse ages and origins of basement complexes, Luzon, Philippines

    SciTech Connect (OSTI)

    Geary, E.E.; Harrison, T.M.; Heizler, M.

    1988-04-01

    Geological field investigations and /sup 40/Ar//sup 39/Ar ages from two basement complexes in southeast Luzon document the first known occurrences of pre-Late Cretaceous age rocks in the eastern Philippines. However, individual components within the two complexes vary in age from Late Jurassic (Caramoan basement complex) to Early Cretaceous and early Miocene (Camarines Norte-Calaguas Islands basement complex). These and other data show that southeast Luzon basement complexes are genetically diverse, and they indicate that the concept of an old, autochthonous basement in the Philippines is open to question. This supports the hypothesis that the Philippine Archipelago is an amalgamation of allochthonous Mesozoic and Cenozoic island-arc, ocean-basin, and continental fragments that were assembled during the Tertiary.

  8. Aging in community

    E-Print Network [OSTI]

    Fay, Justin (Justin Thomas)

    2008-01-01

    Baby Boomers are on the brink of retirement. According to U.S. Census Bureau projections, the number of people aged 65 and over will more than double in the coming decades, growing from 35 million in 2000 to 72 million in ...

  9. Supercomputing Comes of Age

    E-Print Network [OSTI]

    Feng, Xizhou

    Green Supercomputing Comes of Age Wu-chun Feng, Xizhou Feng, and Rong Ge Energy-efficient (green started exploring green supercomputing as a way to achieve au- tonomic energy and power savings and the Department of Energy, conducted a study that found 97 per- cent of businesses could not compete (or exist

  10. Early application case studies

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES Science Network Requirements Report ofEnergyEarly application

  11. Early Notification Gages

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submitKansas Nuclear Profile 2010Mesoscopy andSaving on Fuel The-Early Notification

  12. Aging in Utah: Avoid Crisis

    E-Print Network [OSTI]

    Tipple, Brett

    Aging in Utah: Avoid Crisis Maximize Opportunity UTAH COMMISSION ON AGING Annual Report 2010-2011 #12;Page 1Utah Commission on Aging 2010-2011 Interim Report The Commission's statutory purpose is to: a. increase public and government understanding of the current and future needs of the state's aging

  13. HIV-Encephalitis: Mechanisms for CXCL10 Induction in Astrocytes

    E-Print Network [OSTI]

    Williams, Rachel

    2009-06-23

    months of onset [5]. Before the era of combinational antiretroviral therapy (cART) 20-30% of adults and 50% of children infected with HIV-1 would develop HAD [6]. Even with cART, 60% of individuals are affected by HAND and 9-11% of HIV-1 infected... & multinucleated giant cells, cerebral cortical atrophy, loss of specific neuronal subpopulations, and diffuse white matter pallor [7-11]. Brain inflammation and HAD The CNS has been thought to be an immunologically privileged organ. However, increasing...

  14. HIV trend among Iranian prisoners in 1990s and 2000s; Analysis of aggregated data from HIV sentinel sero-surveys

    E-Print Network [OSTI]

    Haghdoost, Ali-Akbar; Mirzazadeh, Ali; Shokoohi, Mostafa; Sedaghat, Abbas; Gouya, Mohammad

    2013-01-01

    transmission among Iranian prisoners: initial support fortrend among Iranian prisoners in 1990s and 2000s; analysisthe HIV trend among Iranian prisoners. Method: Overall, we

  15. GRADUATE TEACHER EDUCATION PROGRAM EARLY ADMISSIONS PROCESS

    E-Print Network [OSTI]

    education program and be licensed in Early Childhood/Elementary Education. While the minor1 GRADUATE TEACHER EDUCATION PROGRAM EARLY ADMISSIONS PROCESS For Elementary Education Minor ORELA (Early Childhood, Elementary, and Middle Level applicants) Applicants successful in the Early

  16. Supplemental Information Translating HIV sequences into quantitative fitness landscapes to

    E-Print Network [OSTI]

    Ferguson, Andrew

    Supplemental Information Translating HIV sequences into quantitative fitness landscapes to predict contact information. Tel: (617) 253-3890. Fax: (617) 253-2272. Email: arupc@mit.edu. #12;Supplemental Inventory 1. Supplemental Figures and Tables Figure S1, Related to Figure 2 Figure S2, Related to Figure 4

  17. Amplification Dynamics: Predicting the Effect of HIV on Tuberculosis Outbreaks

    E-Print Network [OSTI]

    Blower, Sally

    the virulence of M. tuberculosis and in the planned elimination of tuberculosis in the United States. Key Words of tuberculosis in the United States and for global control of this disease. Previously, we (20­25) and other, but that this amplification effect of HIV on tuberculosis outbreaks is very sensitive to the tuberculosis treatment rate

  18. Early Ceramics from Southern California

    E-Print Network [OSTI]

    Drover, Christopher E.

    1975-01-01

    REPORTS Early Ceramics from Southern California CHRISTOPHERThis paper describes the ceramics and their chronologicalfor dating. To date, 10 ceramic specimens have been

  19. Navigational strategy switching in ageing 

    E-Print Network [OSTI]

    Harris, Mathew Alan

    2014-11-28

    With advancing age, many cognitive faculties deteriorate, and navigation abilities may be among those most affected. The majority of previous work investigating navigation impairments in ageing has focused on allocentric ...

  20. Aging and the labor market

    E-Print Network [OSTI]

    Lahey, Joanna

    2005-01-01

    This thesis is a collection of three essays analyzing the interplay between aging and the labor market. The first chapter demonstrates that differential treatment by age exists in labor markets and explores different ...

  1. Evolution of ageing since Darwin

    E-Print Network [OSTI]

    Rose, Michael R; Burke, Molly K; Shahrestani, Parvin; Mueller, Laurence D

    2008-01-01

    evolution of aging. World Scientific Publishing, Singapore.M. Matos), pp. 237–448. World Scientific Publishing, Sin-

  2. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Lalit S. Shah; William K. Davis

    2000-05-01

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal or coal in combination with some other carbonaceous feedstock. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Test Plan (RD and T) for implementation in Phase II. The objective of Phase II is to conduct RD and T as outlined in the Phase I RD and T Plan to enhance the development and commercial acceptance of Coproduction technology that produces high-value products, particularly those that are critical to our domestic fuel and power requirements. The project will resolve critical knowledge and technology gaps on the integration of gasification and downstream processing to coproduce some combination of power, fuels, and chemicals from coal and other feedstocks. The objective of Phase III is to develop an engineering design package and a financing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information that will be needed to move the EECP forward to detailed design, construction, and operation by industry.

  3. The Age of the Universe

    E-Print Network [OSTI]

    Raul Jimenez

    1997-01-29

    In this article I review the main methods for determining the age of the Universe. I describe how to determine the age of the oldest known systems at z=0, the system of galactic globular clusters, using different techniques. I also describe how to date the Universe using the decay of radioactive elements (Cosmochronology). Finally, I focus on how to determine the age of the Universe at different redshifts and specially the age of radio-quiet galaxies at high redshift. I finish by arguing that the most probable age for the Universe is $14 \\pm 2$ Gyr.

  4. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    John H. Anderson; William K. Davis; Thomas W. Sloop

    2001-03-21

    As part of the Department of Energy's (DOE) Gasification Technologies and Transportation Fuels and Chemicals programs, DOE and Texaco are partners through Cooperative Agreement DE-FC26-99FT40658 to determine the feasibility of developing, constructing and operating an Early Entrance Coproduction Plant (EECP). The overall objective of the project is the three-phase development of an EECP that produces at least one product from at least two of the following three categories: Electric power (or heat); Fuels; and Chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or some other carbonaceous feedstock, such as petroleum coke. The objective of Phase I was to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Testing (RD and T) Plan for implementation in Phase II. This objective has now been accomplished. A specific site, Motiva Refinery in Port Arthur, Texas, has been selected as the location best suited for the EECP. The specific work requirements of Phase I included: Prepare an EECP Preliminary Concept Report covering Tasks 2-8 specified in the Cooperative Agreement; Develop a Research, Development, and Testing (RD and T) Plan as specified in Task 9 of the Cooperative Agreement for implementation in Phase II; and Develop a Preliminary Project Financing Plan for the EECP Project as specified in Task 10 of the Cooperative Agreement. This document is the Preliminary Project Financing Plan for the design, construction, and operation of the EECP at the Motiva Port Arthur Refinery.

  5. Lunar impact basins: Stratigraphy, sequence and ages from superposed impact crater populations measured from Lunar Orbiter Laser Altimeter (LOLA) data

    E-Print Network [OSTI]

    Fassett, Caleb I.

    Impact basin formation is a fundamental process in the evolution of the Moon and records the history of impactors in the early solar system. In order to assess the stratigraphy, sequence, and ages of impact basins and the ...

  6. Impact of HIV/AIDS on the Agricultural Sector in Northern Namibia 

    E-Print Network [OSTI]

    Carter, Charles Russell

    2011-02-22

    of the government to design their extension trainings; however, they are more flexible to do creative outreaches as they do not have to follow the strict governmental guidelines (CIA, 2009). 22 In Namibia, where one in five individuals is HIV positive... ................................................................................. 5 Role of Agricultural Extension workers in HIV Education ........... 7 II IMPACT OF HIV/AIDS ON COMMUNITY LEVEL FOOD SECURITY IN NAMIBIA .................................................................. 8 Introduction...

  7. Caribbean Equal Access Program: HIV/AIDS Information Resources from the National Library of Medicine

    SciTech Connect (OSTI)

    Nancy Dancy, NLM, and Wilma Templin-Branner, ORISE

    2009-01-01

    As the treatment and management of HIV/AIDS continues to evolve with new scientific breakthroughs, treatment discoveries, and management challenges, it is difficult for people living with HIV/AIDS and those who care for them to keep up with the latest information on HIV/AIDS prevention, treatment, and research. The National Library of Medicine, of the National Institutes of Health, has a wealth of health information resources freely available on the Internet to address these needs.

  8. HIV Discrimination in Dental Care: Results of a Discrimination Testing Study In Los Angeles County

    E-Print Network [OSTI]

    Sears, Brad; Cooper, Christian; Younai, Fariba S.; Donohoe, Tom

    2011-01-01

    et al. , Perceived Discrimination in Clinical Care in aId. Brad Sears, HIV Discrimination in Health Care ServicesHighlights: Fighting Discrimination Against Persons with

  9. HIV Discrimination in Dental Care: Results of a Testing Study in Los Angeles Study

    E-Print Network [OSTI]

    Sears, Brad; Cooper, Christian; Younai, Fariba S.; Donohoe, Tom

    2012-01-01

    et al. , Perceived Discrimination in Clinical Care in a809. Spring 2012] HIV DISCRIMINATION IN DENTAL CARE severalthey attributed the discrimination to another characteristic

  10. Proteomic Analysis of Saliva in HIV-positive Heroin Addicts Reveals Proteins Correlated with Cognition

    SciTech Connect (OSTI)

    Dominy, Stephen; Brown, Joseph N.; Ryder, Mark I.; Gritsenko, Marina A.; Jacobs, Jon M.; Smith, Richard D.

    2014-04-01

    The prevalence of HIV-associated neurocognitive disorders (HAND) remains high despite effective antiretroviral therapies. Multiple etiologies have been proposed over the last few years to account for this phenomenon, including the neurotoxic effects of antiretrovirals and co-morbid substance abuse. However, no underlying molecular mechanism has been identified. Emerging evidence in several fields has linked the gut to brain diseases, but the effect of the gut on the brain during HIV infection has not been explored. Saliva is the most accessible gut biofluid, and is therefore of great scientific interest for diagnostic and prognostic purposes. This study presents a longitudinal, liquid chromatography-mass spectrometry-based quantitative proteomics study investigating saliva samples taken from 8 HIV-positive (HIV+) and 11 -negative (HIV-) heroin addicts. In the HIV+ group, 58 proteins were identified that show significant correlations with cognitive scores and that implicate disruption of protein quality control pathways by HIV. Notably, no proteins from the HIV- heroin addict cohort showed significant correlations with cognitive scores. In addition, the majority of correlated proteins have been shown to be associated with exosomes, allowing us to propose that the salivary glands and/or oral epithelium may modulate brain function during HIV infection through the release of discrete packets of proteins in the form of exosomes.

  11. Script generation and multitasking in HIV-1 infection : implications for everyday functioning

    E-Print Network [OSTI]

    Scott, James Cobb

    2009-01-01

    Gagnon S. (2004). Script generation following frontal andGroup. (2005). Action (verb) generation in HIV-1 infection.Note. SG = Script Generation test; MT = Multitasking test. *

  12. The effects of housing stability and the residential environment on HIV risk factors and tuberculosis

    E-Print Network [OSTI]

    Lindsay, Ryan Paul

    2012-01-01

    Wood E. Homelessness and unstable housing associated with anrisk through multiple housing measures. AIDS and behaviorHarre D, Sumartojo E. Housing status and HIV risk behaviors:

  13. Living and Dying Abroad: Aspects of Egyptian Cultural Identity in Late Bronze Age and Early Iron Age Canaan

    E-Print Network [OSTI]

    Pierce, Krystal Victoria Lords

    2013-01-01

    A.L. 1950 “On Beer and Brewing Techniques in Ancient2003 A History of Beer and Brewing. Cambridge. Hornung, E.and Maytag, F. 1991 “Brewing an Ancient Beer. ” Archaeology

  14. Living and Dying Abroad: Aspects of Egyptian Cultural Identity in Late Bronze Age and Early Iron Age Canaan

    E-Print Network [OSTI]

    Pierce, Krystal Victoria Lords

    2013-01-01

    two-step formation, perforation, rope- drying, and massThe female skeleton had a perforation above the right eyeThe presence of a perforation above the right eye socket of

  15. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Fred D. Brent; Lalit Shah; Earl Berry; Charles H. Schrader; John Anderson; Ming He; James F. Stevens; Centha A. Davis; Michael Henley; Jerome Mayer; Harry Tsang; Jimell Erwin; Jennifer Adams; Michael Tillman; Chris Taylor; Marjan J. Roos; Robert F. Earhart

    2004-01-27

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems was assessed for technical risks and barriers. A plan was developed to mitigate the identified risks (Phase II RD&T Plan, October 2000). The potential technical and economic risks to the EECP from Task 2.5 can be mitigated by demonstrating that the end-use products derived from the upgrading of the F-T synthesis total liquid product can meet or exceed current specifications for the manufacture of ethylene and propylene chemicals from F-T naphtha, for the generation of hydrogen from F-T naphtha to power fuel cells, for direct blending of F-T diesels into transportation fuels, for the conversion of F-T heavy product wax to transportation fuels, and the conversion of F-T Heavy product wax to a valuable high melting point food-grade specialty wax product. Product evaluations conducted under Task 2.5 of Phase II successfully mitigated the above technical and economic risks to the EECP with the development of product yields and product qualities for the production of chemicals, transportation fuels, and specialty food-grade waxes from the F-T synthesis products.

  16. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    John Anderson; Charles Schrader

    2004-01-26

    In 1999, the U. S. Department of Energy (DOE) awarded a Cooperative Agreement to Texaco Energy Systems Inc. to provide a preliminary engineering design of an Early Entrance Coproduction Plant (EECP). Since the award, continuous and diligent work has been undertaken to achieve the design of an economical facility that makes strides toward attaining the goal of DOE's Vision 21 Program. The objective of the EECP is to convert coal and/or petroleum coke to power while coproducing transportation fuels, chemicals, and useful utilities such as steam. This objective is being pursued in a three-phase effort through the partnership of the DOE with prime contractor Texaco Energy Systems, LLC. (TES), the successor to Texaco Energy Systems, Inc. The key subcontractors to TES include General Electric (GE), Praxair, and Kellogg Brown and Root. ChevronTexaco provided gasification technology and Rentech Inc.'s Fischer-Tropsch (F-T) technology that has been developed for non-natural gas sources. GE provided gas turbine technology for the combustion of low energy content gas. Praxair provided air separation technology and KBR provided engineering to integrate the facility. A conceptual design was completed in Phase I and the report was accepted by the DOE in May 2001. The Phase I work identified risks and critical research, development, and testing that would improve the probability of technical success of the EECP. The objective of Phase II was to mitigate the risks by executing research, development, and testing. Results from the Phase II work are the subject of this report. As the work of Phase II concluded, it became evident that sufficient, but not necessarily complete, technical information and data would be available to begin Phase III - Preliminary Engineering Design. Work in Phase II requires additional technical development work to correctly apply technology at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The decision to proceed with Phase III centers on locating a new site and favorable commercial and economic factors.

  17. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    David Storm; Govanon Nongbri; Steve Decanio; Ming He; Lalit Shah; Charles Schrader; Earl Berry; Peter Ricci; Belma Demirel; Charles Benham; Mark Bohn

    2004-01-12

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, Inc., GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. During Phase I, a design basis for the Fischer-Tropsch Synthesis section was developed based on limited experience with the specified feed gas and operating conditions. The objective of this Task in Phase II RD&T work was to confirm the performance of the F-T reactor at the set design conditions. Although much of the research, development, and testing work were done by TES outside of this project, several important issues were addressed in this phase of the project. They included Rejuvenation/Regeneration of the Fischer-Tropsch Catalyst, online Catalyst Withdrawal and Addition from the synthesis reactor, and the Fischer-Tropsch Design Basis Confirmation. In Phase III the results from these RD&T work will be incorporated in developing the engineering design package. This Topical Report documents the Phase II RD&T work that was completed for this task.

  18. Mutational Escape in HIV-1 CTL Epitopes Leads to Increased Binding to Inhibitory Myelomonocytic MHC Class I Receptors

    E-Print Network [OSTI]

    Yang, Yue

    Escape mutations in HIV-1 cytotoxic T cell (CTL) epitopes can abrogate recognition by the TCR of HIV-1-specific CD8+ T cells, but may also change interactions with alternative MHC class I receptors. Here, we show that ...

  19. Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI

    E-Print Network [OSTI]

    2010-01-01

    potently inhibited DC-SIGN-mediated transmission of HIV-1 (expression of DC-SIGN strongly enhanced transmission of HIV-the case of DC- SIGN-mediated virus transmission. Next, we

  20. The role of non-formal education in combating the HIV epidemic in the Philippines and Taiwan

    E-Print Network [OSTI]

    Morisky, Donald E.; Lyu, Shu-Yu; Urada, Lianne A.

    2009-01-01

    15–49) HIV infection in Taiwan till year 2003. Formosanaddition treatment, Taipei, Taiwan. The role of non-formalH. S. (2007). HIV-1 in Taiwan. The Lancet, 369(9562), 623–

  1. Early lunar geology and geophysics

    E-Print Network [OSTI]

    Garrick-Bethell, Ian, 1980-

    2009-01-01

    Despite a number of human and robotic missions to the Moon, there are still important unanswered questions about its early evolution, and how it came to be the object we observe today. Here we use observational, experimental, ...

  2. String Theory: The Early Years

    E-Print Network [OSTI]

    John H. Schwarz

    2000-07-26

    Lenny Susskind has made many important contributions to theoretical physics during the past 35 years. In this talk I will discuss the early history of string theory (1968-72) emphasizing Susskind's contributions.

  3. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Abdalla H. Ali; Raj Kamarthi; John H. Anderson; Earl R. Berry; Charles H. Schrader; Lalit S. Shah

    2003-04-16

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. During Phase I the team identified the integration of the water produced in the F-T synthesis section with the gasification section as an area of potential synergy. By utilizing the F-T water in the petroleum coke slurry for the gasifier, the EECP can eliminate a potential waste stream and reduce capital costs. There is a low technical risk for this synergy, however, the economic risk, particularly in regards to the water, can be high. The economic costs include the costs of treating the water to meet the locally applicable environmental standards. This option may require expensive chemicals and treatment facilities. EECP Phase II included tests conducted to confirm the viability of integrating F-T water in the slurry feed for the gasifier. Testing conducted at ChevronTexaco's Montebello Technology Center (MTC) included preparing slurries made using petroleum coke with F-T water collected at the LaPorte Alternative Fuels Development Unit (AFDU). The work included bench scale tests to determine the slurry ability of the petroleum coke and F-T water. The results of the tests show that F-T water does not adversely affect slurries for the gasifier. There are a few cases where in fact the addition of F-T water caused favorable changes in viscosity of the slurries. This RD&T task was executed in Phase II and results are reported herein.

  4. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Randy Roberts

    2003-04-25

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using petroleum coke and ChevronTexaco's proprietary gasification technology. The objective of Phase I was to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC. (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). ChevronTexaco is providing gasification technology and Fischer-Tropsch technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology and KBR is providing engineering. Each of the EECP subsystems were assessed for technical risks and barriers. A plan was identified to mitigate the identified risks (Phase II RD&T Plan, October 2000). The RD&T Plan identified F-T reactor scale-up as a potential technical risk. The objective of Task 2.3 was to confirm engineering models that allow scale-up to commercial slurry phase bubble column (SPBC) reactors operating in the churn-turbulent flow regime. In developmental work outside the scope of this project, historical data, literature references, and a scale-up from a 1 1/2-in. (3.8 cm) to 6-ft (1.8 m) SPBC reactor have been reviewed. This review formed the background for developing scale-up models for a SPBC reactor operating in the churn-turbulent flow regime. The necessary fundamental physical parameters have been measured and incorporated into the mathematical catalyst/kinetic model developed from the SPBC and CSTR work outside the scope of this EECP project. The mathematical catalyst/kinetic model was used to compare to experimental data obtained at Rentech during the EECP Fischer-Tropsch Confirmation Run (Task 2.1; reported separately). The prediction of carbon monoxide (CO) conversion as a function of days on stream compares quite closely to the experimental data.

  5. Wisconsin Technical College System Early Childhood Education

    E-Print Network [OSTI]

    Saldin, Dilano

    Wisconsin Technical College System Early Childhood Education University of Wisconsin.A.S. Early Childhood Education University of Wisconsin-Milwaukee Baccalaureate Degree Community Education System (WTCS) Early Childhood Education AAS programs and the University of Wisconsin-Milwaukee (UWM

  6. Early Childhood Education and School Readiness: Conceptual

    E-Print Network [OSTI]

    Rau, Don C.

    Early Childhood Education and School Readiness: Conceptual Models, Constructs, and Measures and Evaluation. #12;Early Childhood Education and School Readiness Workshop, June 17-18, 2002 TABLE OF CONTENTS .................................................................................................................................................13 Language and Early Literacy

  7. Phase Transitions in the Early Universe

    E-Print Network [OSTI]

    Wainwright, Carroll Livingston

    2013-01-01

    Phase Transitions in the Early Universe by Carroll L.and computation of early-Universe finite-temperature phaseM. S. Turner, “The Early universe,” Front. Phys. 69 (1990)

  8. Early Admission Supplemental Application Page 1 Date ________________

    E-Print Network [OSTI]

    Fernandez, Eduardo

    Early Admission Supplemental Application Page 1 Date ________________ Student Name Admission Supplemental Application Page 2 Supplemental Information for Early Admission Student Statement

  9. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Fred D. Brent; Lalit Shah; Earl Berry; Charles H. Schrader; John Anderson; J. Erwin; Matthew G. Banks; Terry L. Ullman

    2004-01-12

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems was assessed for technical risks and barriers. A plan was developed to mitigate the identified risks (Phase II RD&T Plan, October 2000). Phase II RD&T Task 2.6 identified as potential technical risks to the EECP the fuel/engine performance and emissions of the F-T diesel fuel products. Hydrotreating the neat F-T diesel product reduces potentially reactive olefins, oxygenates, and acids levels and alleviates corrosion and fuel stability concerns. Future coproduction plants can maximize valuable transportation diesel by hydrocracking the F-T Synthesis wax product to diesel and naphtha. The upgraded neat F-T diesel, hydrotreater F-T diesel, and hydrocracker F-T diesel products would be final blending components in transportation diesel fuel. Phase II RD&T Task 2.6 successfully carried out fuel lubricity property testing, fuel response to lubricity additives, and hot-start transient emission tests on a neat F-T diesel product, a hydrocracker F-T diesel product, a blend of hydrotreater and hydrocracker F-T diesel products, and a Tier II California Air Resources Board (CARB)-like diesel reference fuel. Only the neat F-T diesel passed lubricity inspection without additive while the remaining three fuel candidates passed with conventional additive treatment. Hot-start transient emission tests were conducted on the four fuels in accordance with the U.S. Environmental Protection Agency (EPA) Federal Test Procedure (FTP) specified in Code of Federal Regulations, Title 40, Part 86, and Subpart N on a rebuilt 1991 Detroit Diesel Corporation Series 60 heavy-duty diesel engine. Neat F-T diesel fuel reduced oxides of nitrogen (NO{sub x}), total particulate (PM), hydrocarbons (HC), carbon monoxide (CO), and the Soluble Organic Fraction (SOF) by 4.5%, 31%, 50%, 29%, and 35%, respectively, compared to the Tier II CARB-like diesel. The hydrocracker F-T diesel product and a blend of hydrocracker and hydrotreater F-T diesel products also reduced NO{sub x}, PM, HC, CO and SOF by 13%, 16% to 17%, 38% to 63%, 17% to 21% and 21% to 39% compared to the Tier II CARB-like diesel. The fuel/engine performance and emissions of the three F-T diesel fuels exceed the performance of a Tier II CARB-like diesel. Phase II RD&T Task 2.6 successfully met the lubricity property testing and F-T diesel fuel hot-start transient emissions test objectives. The results of the testing help mitigate potential economic risks on obtaining a premium price for the F-T diesel fuel

  10. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Abdalla H. Ali; John H. Anderson; Earl R. Berry; Charles H. Schrader; Lalit S. Shah

    2003-04-16

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems were assessed for technical risks and barriers. A plan was identified to mitigate the identified risks (Phase II RD&T Plan, October 2000). The RD&T Plan identified petroleum coke characteristics as a potential technical risk. The composition of petroleum coke varies from one refinery to another. Petroleum coke characteristics are a function of the crude oil slate available at the refinery and the coker operating parameters. The specific petroleum coke characteristics at a refinery affect the design of the Gasification and Acid Gas Removal (AGR) subsystems. Knowing the petroleum coke composition provides the necessary data to proceed to the EECP Phase III engineering design of the gasification process. Based on ChevronTexaco's experience, the EECP team ranked the technical, economic, and overall risks of the petroleum coke composition related to the gasification subsystem as low. In Phase I of the EECP Project, the Motiva Port Arthur Refinery had been identified as the potential EECP site. As a result of the merger between Texaco and Chevron in October 2001, Texaco was required to sell its interest in the Motiva Enterprises LLC joint venture to Shell Oil Company and Saudi Refining Inc. To assess the possible impact of moving the proposed EECP host site to a ChevronTexaco refinery, samples of petroleum coke from two ChevronTexaco refineries were sent to MTC for bench-scale testing. The results of the analysis of these samples were compared to the Phase I EECP Gasification Design Basis developed for Motiva's Port Arthur Refinery. The analysis confirms that if the proposed EECP is moved to a new refinery site, the Phase I EECP Gasification Design Basis would have to be updated. The lower sulfur content of the two samples from the ChevronTexaco refineries indicates that if one of these sites were selected, the Sulfur Recovery Unit (SRU) might be sized smaller than the current EECP design. This would reduce the capital expense of the SRU. Additionally, both ChevronTexaco samples have a higher hydrogen to carbon monoxide ratio than the Motiva Port Arthur petroleum coke. The higher hydrogen to carbon monoxide ratio could give a slightly higher F-T products yield from the F-T Synthesis Reactor. However, the EECP Gasification Design Basis can not be updated until the site for the proposed EECP site is finalized. Until the site is finalized, the feedstock (petroleum coke) characteristics are a low risk to the EECP project.

  11. Uncertainty Quantification in Modeling HIV Viral Mechanics H.T. Banks1,2

    E-Print Network [OSTI]

    Uncertainty Quantification in Modeling HIV Viral Mechanics H.T. Banks1,2 , Robert Baraldi1 for the resulting parameter estimates. Key Words: In-host HIV-1 progression models, uncertainty quantification of [7] for further analysis. A major motivation for revisiting this model is its potential to be readily

  12. Identifying the Membrane Proteome of HIV-1 Latently Infected Cells*S

    E-Print Network [OSTI]

    Vertes, Akos

    Identifying the Membrane Proteome of HIV-1 Latently Infected Cells*S Received for publication, **Department of Biochemistry/ Center for Sickle Cell Disease, Howard University, Washington, D. C. 20059 of established human immunodeficiency virus-1 (HIV-1) latent cell models and parental cell lines. To this end we

  13. TCells in the Presence of HIV (Part 2 of 2) Step I --Background

    E-Print Network [OSTI]

    Meade, Douglas B.

    understand the full model. The final qualitative results should be consistent with what you know about T­cellsT­Cells in the Presence of HIV (Part 2 of 2) Step I -- Background Perelson, Kerschner, and DeBoer [4] have presented a model for the interaction of T­cells and HIV. In the project ``Normal T­Cells

  14. Comparative analysis of protein interaction networks reveals that conserved pathways are susceptible to HIV-1 intercep-

    E-Print Network [OSTI]

    Yoon, Byung-Jun

    are susceptible to HIV-1 intercep- tion Xiaoning Qian1 , Byung-Jun Yoon2 1Department of Computer Science and Engineering, University of South Florida, Tampa, FL, USA 2Department of Electrical and Computer Engineering- bjyoon@ece.tamu.edu; Corresponding author Abstract Background: Human immunodeficiency virus type one (HIV

  15. 5Social Construction of Gender and Sexuality in Online HIV/AIDS Information

    E-Print Network [OSTI]

    Kvasny, Lynette

    /WHO, 2004), women now make up nearly half of all people living with HIV worldwide. In the United States closer at HIV and AIDS infections among women in the United States, Anderson and Smith (2004) report Pennsylvania State University, USA Lynette Kvasny Pennsylvania State University, USA Copyright © 2006, Idea

  16. 58 International Family Planning Perspectives The number of HIV infections in central and eastern Eu-

    E-Print Network [OSTI]

    obstacle. BACKGROUND At the moment, the rate of HIV infection in Croatia is low and has been stable over is driven primarily by intravenous drug use, in Croatia, HIV is transmitted pri- marily through heterosexual% of all documented AIDS cases. In Croatia, as in the wider region, young people seem to be particularly

  17. GB Virus Type C (HGV) and Human Immunodeficiency Virus (HIV) Co-Infection: Incidence and Impacts on Survival in a Cohort of HIV-Infected Transfusion Recipients

    E-Print Network [OSTI]

    Vahidnia, Farnaz

    2011-01-01

    you need to know about GB virus C. Curr Gastroenterol Rep.of the hepatitis G virus. J Viral Hepat. 6. Simons JN,Stapleton JT, Chaloner K. GB virus C and survival in HIV-

  18. Gentrifying geriatrics : challenging design paradigms for the aged and aging

    E-Print Network [OSTI]

    Van der Linde, Gerhard J. (Gerhard Johan)

    2011-01-01

    Internationally the world is undergoing a grey revolution, with the average age of the human population being higher than it has ever been before. Within the U.S. context this trend is driven by the Baby Boomers, the 80 ...

  19. AGING SYSTEM DESIGN DEVELOPMENT STRATEGY

    SciTech Connect (OSTI)

    J. Beesley

    2005-02-07

    This plan provides an overview, work to date, and the path forward for the design development strategy of the Aging cask for aging commercial spent nuclear fuel (CSNF) at the Yucca Mountain Project (YMP) repository site. Waste for subsurface emplacement at the repository includes US Department of Energy (DOE) high-level radioactive waste (HLW), DOE SNF, commercial fuel in dual-purpose canisters (DPCs), uncanistered bare fuel, naval fuel, and other waste types. Table 1-1 lists the types of radioactive materials that may be aged at YMP, and those materials that will not be placed in an aging cask or module. This plan presents the strategy for design development of the Aging system. The Aging system will not handle naval fuel, DOE HLW, MCOs, or DOE SNF since those materials will be delivered to the repository in a state and sequence that allows them to be placed into waste packages for emplacement. Some CSNF from nuclear reactors, especially CSNF that is thermally too hot for emplacement underground, will need to be aged at the repository.

  20. Early History & Fiction! Orbital Motion!

    E-Print Network [OSTI]

    Stengel, Robert F.

    OF THE ENLIGHTENMENT; INDUSTRIAL REVOLUTION. 1781: Herschel discovers Uranus. 1800s: Exploits of Napoleon. Steamships; Glaisher & Coxwell to 35K ft Voltaire, Micromégas (1752) AMERICAN REVOLUTION; FRENCH REVOLUTION; AGE

  1. Montana State University 1 Early Childhood Education

    E-Print Network [OSTI]

    Maxwell, Bruce D.

    Montana State University 1 Early Childhood Education and Child Services Major The early work and field experience focuses on early childhood education, child development, developmentally program to Montana Tribal Colleges and respective HeadStart Programs through the Early Childhood Education

  2. Brothers, Sisters and Aging Parents 

    E-Print Network [OSTI]

    Isbell, Lou

    1999-09-02

    Adult children play a crucial role in helping aging parents. When relationships with siblings are poor, everyone suffers. Brothers and sisters can build strong relationships and unite in caring for elderly parents when they learn to relate to each...

  3. Cell Senescence: Aging and Cancer

    ScienceCinema (OSTI)

    Campisi, Judith

    2013-05-29

    Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals.

  4. Accelerated Aging of Roofing Surfaces

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Accelerated aging of roofing surfaces Hugo Destaillats, Ph.D. Lawrence Berkeley National Laboratory HDestaillats@LBL.gov (510) 486-5897 http:HeatIsland.LBL.gov April 4, 2013...

  5. Early Warning of Network Catastrophes

    E-Print Network [OSTI]

    resilience of nation's networks Reduce cost of widespread outages and degradations Transfer methods to other systems of national importance, e.g., computational clouds, cyber- physical systems, smart power grids August 28, 2014 Early Warning of Network Catastrophes 2 #12;Argument in Brief Problem

  6. Education, Early Years, Childhood, Youth

    E-Print Network [OSTI]

    Education, Early Years, Childhood, Youth and Community Postgraduate 2013 #12;Welcome Manchester childhood specialists, careers advisors and education managers. We also offer an extensive and flexible of Education has a global vision which can help you realise your ambitions. Studying within a lively

  7. Early English Books on microfilm

    E-Print Network [OSTI]

    search term in one box, or two if you are combining or excluding terms. You can leave the Search Three. In the next search box, enter the words early english books. Leave the other defaults alone. Now access the catalog (libcat.wichita.edu), change the default to Advanced Search: Step Two. Place your

  8. AT NORTHWESTERN EARLY CANCER DETECTION

    E-Print Network [OSTI]

    Chisholm, Rex L.

    --including lung cancer, pancreatic cancer, and ovarian cancer-- there is simply no screening option available, such as pancreatic, ovarian, and lung cancer. · Improve existing screening techniques, such as those for colon cancer, with the THE CANCER INSTITUTES AT NORTHWESTERN MEDICINE EARLY CANCER DETECTION TECHNOLOGIES INSTITUTE

  9. Multipath Probabilistic Early Response TCP 

    E-Print Network [OSTI]

    Singh, Ankit

    2012-10-19

    by the combined early response and con- gestion response probabilities and is given by 1 (1 p)(1 p0) = p+ p0 p p0 . If PERT has to roughly get an equal share when competing with TCP, comparing the steady state throughput equations of the two protocols, we...

  10. Wrapping up the bad news - HIV assembly and release

    E-Print Network [OSTI]

    Meng, Bo; Lever, Andrew ML

    2013-01-10

    contrast to evidence from siRNA knock down studies in vivo [12] which suggest that ESCRT-II is dispensable. This apparent discrepancy is puzzling but may be due to incomplete protein depletion by siRNA if only a small amount of ESCRT-II is needed for HIV-1... :439–456. 34. Tang Y, Winkler U, Freed EO, Torrey TA, Kim W, Li H, Goff SP, Morse HC: 3rd: Cellular motor protein KIF-4 associates with retroviral Gag. J Virol 1999, 73:10508–10513. 35. Dong X, Li H, Derdowski A, Ding L, Burnett A, Chen X, Peters TR, Dermody TS...

  11. Equal Access Initiative HIV/AIDS Information Resources from NLM

    SciTech Connect (OSTI)

    Templin-Branner W. and N. Dancy

    2010-09-11

    The Equal Access Initiative: HIV/AIDS Information Resources from the National Library of Medicine training is designed specifically for the National Minority AIDS Council 2010 Equal Access Initiative (EAI) Computer Grants Program awardees to provide valuable health information resources from the National Library of Medicine and other reliable sources to increase awareness of the wealth of treatment information and educational materials that are available on the Internet and to improve prevention and treatment education for their clients. These resources will also meet the needs of community-based

  12. Questioning the HIV-AIDS hypothesis: 30 years of dissent 

    E-Print Network [OSTI]

    Goodson, Patricia

    2014-09-23

    PUBLIC HEALTH OPINION ARTICLE published: 23 September 2014 doi: 10.3389/fpubh.2014.00154 Questioning the HIV-AIDS hypothesis: 30 years of dissent Patricia Goodson* Department of Health & Kinesiology, Texas A&M University, College Station, TX, USA... it is important to remember: over 60 conditions can yield a false-positive ELISA) (13, 18). Critics of the orthodox view decry the lack of standardized criteria for a positive result in a WB, across countries, world- wide (19). Bauer (Table 1), in a 2010 arti- cle...

  13. HIV vaccine research focus of Laboratory-sponsored talk

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFESOpportunitiesNERSCGrid-based29 1.921HEP UserHIV vaccine research

  14. HIV virus spread and evolution studied through computer modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFESOpportunitiesNERSCGrid-based29 1.921HEP UserHIV vaccine

  15. The interaction of RNA helicase DDX3 with HIV-1 Rev-CRM1-RanGTP complex during the HIV replication cycle

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mahboobi, Seyed Hanif; Javanpour, Alex A.; Mofrad, Mohammad R. K.

    2015-02-27

    Molecular traffic between the nucleus and the cytoplasm is regulated by the nuclear pore complex (NPC), which acts as a highly selective channel perforating the nuclear envelope in eukaryotic cells. The human immunodeficiency virus (HIV) exploits the nucleocytoplasmic pathway to export its RNA transcripts across the NPC to the cytoplasm. Despite extensive study on the HIV life cycle and the many drugs developed to target this cycle, no current drugs have been successful in targeting the critical process of viral nuclear export, even though HIV’s reliance on a single host protein, CRM1, to export its unspliced and partially spliced RNAmore »transcripts makes it a tempting target. Due to recent findings implicating a DEAD-box helicase, DDX3, in HIV replication and a member of the export complex, it has become an appealing target for anti-HIV drug inhibition. In the present research, we have applied a hybrid computational protocol to analyze protein-protein interactions in the HIV mRNA export cycle. This method is based on molecular docking followed by molecular dynamics simulation and accompanied by approximate free energy calculation (MM/GBSA), computational alanine scanning, clustering, and evolutionary analysis. We highlight here some of the most likely binding modes and interfacial residues between DDX3 and CRM1 both in the absence and presence of RanGTP. This work shows that although DDX3 can bind to free CRM1, addition of RanGTP leads to more concentrated distribution of binding modes and stronger binding between CRM1 and RanGTP.« less

  16. Appreciating HIV-1 diversity: subtypic differences in ENV

    SciTech Connect (OSTI)

    Gnanakaran, S; Shen, Tongye; Lynch, Rebecca M; Derdeyn, Cynthia A

    2008-01-01

    Human immunodeficiency virus type 1 (HIV-1) group M is responsible for the current AIDS pandemic and exhibits exceedingly high levels of viral genetic diversity around the world, necessitating categorization of viruses into distinct lineages, or subtypes. These subtypes can differ by around 35% in the envelope (Env) glycoproteins of the virus, which are displayed on the surface of the virion and are targets for both neutralizing antibody and cell-mediated immune responses. This diversity reflects the remarkable ability of the virus to adapt to selective pressures, the bulk of which is applied by the host immune response, and represents a serious obstacle for developing an effective vaccine with broad coverage. Thus, it is important to understand the underlying biological consequences of inter-subtype diversity. Recent studies have revealed that the HIV-1 subtypes exhibit phenotypic differences that result from subtle differences in Env structure, particularly within the highly immunogenic V3 domain, which participates directly in viral entry. This review will therefore explore current research that describes subtypic differences in Env at the genetic and phenotypic level, focusing in particular on V3, and highlighting recent discoveries about the unique features of subtype C Env, which is the most prevalent subtype globally.

  17. Developing a Dynamic Pharmacophore Model for HIV-1 Integrase

    SciTech Connect (OSTI)

    Carlson, Heather A.; Masukawa, Keven M.; Rubins, Kathleen; Bushman, Frederic; Jorgensen, William L.; Lins, Roberto; Briggs, James; Mccammon, Andy

    2000-05-11

    We present the first receptor-based pharmacophore model for HIV-1 integrase. The development of ''dynamic'' pharmacophore models is a new method that accounts for the inherent flexibility of the active site and aims to reduce the entropic penalties associated with binding a ligand. Furthermore, this new drug discovery method overcomes the limitation of an incomplete crystal structure of the target protein. A molecular dynamics (MD) simulation describes the flexibility of the uncomplexed protein. Many conformational models of the protein are saved from the MD simulations and used in a series of multi-unit search for interacting conformers (MUSIC) simulations. MUSIC is a multiple-copy minimization method, available in the BOSS program; it is used to determine binding regions for probe molecules containing functional groups that complement the active site. All protein conformations from the MD are overlaid, and conserved binding regions for the probe molecules are identified. Those conserved binding regions define the dynamic pharmacophore model. Here, the dynamic model is compared to known inhibitors of the integrase as well as a three-point, ligand-based pharmacophore model from the literature. Also, a ''static'' pharmacophore model was determined in the standard fashion, using a single crystal structure. Inhibitors thought to bind in the active site of HIV-1 integrase fit the dynamic model but not the static model. Finally, we have identified a set of compounds from the Available Chemicals Directory that fit the dynamic pharmacophore model, and experimental testing of the compounds has confirmed several new inhibitors.

  18. WHOLE-ROCK 87Sr/86Sr COMPOSITION AND APPARENT STRONTIUM ISOTOPIC AGE OF LIMESTONES FROM SITE 1118, WOODLARK RIFT BASIN, SOUTHWEST PACIFIC (OCEAN DRILLING PROGRAM LEG 180) 

    E-Print Network [OSTI]

    Allan, Tony; Robertson, Alastair H F; Sharp, Timothy R; Trotter, Julie

    2001-01-01

    Limestone from Unit VI (857.1–859.15 meters below seafloor) collected at Site 1118 contains a planktonic foraminiferal fauna indicating a latest Miocene to early Pliocene age. Globorotalia tumida is recorded in Sample ...

  19. Minimizing Leakage Energy in FPGAs Using Intentional Post-Silicon Device Aging

    E-Print Network [OSTI]

    Wei, Sheng

    2013-01-01

    Aging Model . . . . . . . . . . . . . . . . . . . . .Aging Configuration . . . . . . . . . . . . . .Limitation . . . . . . . . . . . . . . . . . 6 Aging-based

  20. A review of "Early Modern French Thought: The Age of Suspicion." by Michael Moriarty 

    E-Print Network [OSTI]

    Todd Janke

    2006-01-01

    Descartes, however, the goal of this resistance for Malebranche, Moriarty writes, was not only to better grasp the nature of truth and certainty but to understand the soul?s essential closeness to God. What is to be understood as the achieve- ment... of Descartes? philosophical work for Malebranche is not simply that ?the soul, and God, are more easily known than the body,? but that ?the soul is actually more essentially united to God than to the body? (152). The importance of this claim is that suspicion...

  1. ‘Fire Burn and Cauldron Bubble’: Iron Age and Early Roman Cauldrons of Britain and Ireland

    E-Print Network [OSTI]

    Joy, Jody

    2014-10-28

    of cauldrons are sometimes also recovered at settlements, perhaps remnants from dismantling and/or recycling or alternatively relating to specific fragmentation practice. Beach 1 Burial 4 Bog/Moss 7 Hoard 19 Lake/Loch 9 River 4 Settlement 10 Unknown...

  2. Physical Activity, Sedentary Time and Physical Capability in Early Old Age: British Birth Cohort Study

    E-Print Network [OSTI]

    Cooper, Andrew J. M.; Simmons, Rebecca K.; Kuh, Diana; Brage, Søren; Cooper, Rachel; NSHD scientific and data collection team

    2015-05-11

    .4 (2.2) 17.3 (2.0) Time spent in MVPA (min/day) 90.5 (64.9) 79.9 (54.9) PAEE (kJ/kg/day) 38.1 (15.7) 34.2 (13.3) Anthropometry b Height (cm) 174.8 (6.6) 161.7 (6.0) Weight (kg) 85.0 (13.6) 73.2 (14.8) Education level c Degree or higher 134 (16.9) 54 (6... O, Fallert SV, MacKay DJ, Brage S. Gaussian process robust regression for noisy heart rate data. IEEE transactions on bio-medical engineering. 2008; 55(9):2143–51. Epub 2008/08/21. doi: 10. 1109/tbme.2008.923118 PMID: 18713683. 29. Brage S, Brage N...

  3. Modeling the Effect of Curing on Early Age Distress Potential of Concrete Pavement 

    E-Print Network [OSTI]

    Bari, Muhammad Ehsanul

    2014-04-11

    , drying shrinkage, were obtained from experimental program and were used as input in these distress prediction models. In order to assess the effectiveness of different curing compounds, two indices, such as curing index and overall curing index, were...

  4. Sex allocation in a species with paternal genome elimination: the roles of crowding and female age

    E-Print Network [OSTI]

    Shuker, David

    Sex allocation in a species with paternal genome elimination: the roles of crowding and female age with paternal genome elimination, both sexes are diploid. However, in males the chromosomes inherited from the father are deactivated during early development and eliminated from the germ line. Sex allocation theory

  5. Melatonin, oxidative stress and the aging brain

    E-Print Network [OSTI]

    Bondy, SC; Sharman, EH

    2010-01-01

    markers in healthy aging and Alzheimer’s disease.Neurobiol Aging. 8. Kim R, Emi M, Tanabe K. Role ofFree radicals and brain aging. Clin Geriatr Med. 2004;20:

  6. Telomere lengthening to antagonize myocardial aging

    E-Print Network [OSTI]

    Cottage, Christopher Travis; Cottage, Christopher Travis

    2012-01-01

    targets to antagonize the aging phenotype. FIGURES Figureday Pim-wt. Figure 2.2: Cellular aging markers over time. A.stem cell and myocyte aging, heart failure, and insulin-like

  7. Fracture, aging and disease in bone

    E-Print Network [OSTI]

    Ager, J.W.; Balooch, G.; Ritchie, R.O.

    2006-01-01

    and R. O. Ritchie: Effect of aging on the toughness of humanof microstructure in the aging-related deterioration of thestudy of the effect of aging on human cortical bone J.

  8. Neural correlates of successful cognitive aging

    E-Print Network [OSTI]

    Kaup, Allison Renee

    2012-01-01

    default network" in normal aging. Cereb Cortex, 18(8), 1856-The posterior-anterior shift in aging. Cereb Cortex, 18(5),atrophy evident in healthy aging. J Neurosci, Fjell, A. M. ,

  9. Elucidating mechanisms of accelerated neurological aging

    E-Print Network [OSTI]

    Greenhall, Jennifer Anne

    2008-01-01

    C. (2005). Mechanisms of aging in senescence- accelerated2.2 Strain-specific aging gene-expression profiles…………………..C. (2005). Mechanisms of aging in senescence-accelerated

  10. AGEING & SEXING AGEING AND SEXING OF THE AFRICAN

    E-Print Network [OSTI]

    de Villiers, Marienne

    with narrow lime greel gr bases, Eving a moftled appea.rance when ihey yellow Tgrgns on the outer web lighter as the are blackish or dark brown with very thin lime plumage ages. Blackish ones liqime brown-withavariableamolntoflimeg{een the iris biown or dark brown. The legs ind on the.-fringeq 9{ttre feathers

  11. Non-uniform Aging on Super Duty Diesel Truck Aged Urea Cu/Zeolite...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    uniform Aging on Super Duty Diesel Truck Aged Urea CuZeolite SCR Catalysts Non-uniform Aging on Super Duty Diesel Truck Aged Urea CuZeolite SCR Catalysts CuZeolite SCR catalysts...

  12. Transportation, Aging and Disposal Canister System Performance...

    Broader source: Energy.gov (indexed) [DOE]

    document provides specifications for selected system components of the Transportation, Aging and Disposal (TAD) canister-based system. Transportation, Aging and Disposal Canister...

  13. Recommendation 177: Facilitating Early Public Input

    Broader source: Energy.gov [DOE]

    DOE should initiate consultation meetings with stake holders immediately to allow early public input into the planning for IFDP

  14. Acceptability and Use of the Diaphragm and Replens® Lubricant Gel for HIV Prevention in Southern Africa

    E-Print Network [OSTI]

    2010-01-01

    G, et al. Diaphragm and lubricant gel for prevention of HIVT, et al. The diaphragm and lubricant gel for prevention ofDiaphragm and Replens Ò Lubricant Gel for HIV Prevention in

  15. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

    E-Print Network [OSTI]

    Barouch, Dan H.

    Human immunodeficiency virus type 1 (HIV-1)-specific monoclonal antibodies with extraordinary potency and breadth have recently been described. In humanized mice, combinations of monoclonal antibodies have been shown to ...

  16. HIV/AIDS risk behaviors and correlates of injection drug use among drug users in Pakistan.

    E-Print Network [OSTI]

    2003-01-01

    transfusion risks in Karachi, Pakistan. Int J Infect Dis.dis- orders in Pakistan. AIDS Res Hum Retroviruses. 1988;4:threat: HIV/AIDS policy in Pakistan. Health Policy Plann.

  17. HIV tests and new diagnoses declined after California budget cuts, but reallocating funds helped reduce impact

    E-Print Network [OSTI]

    Leibowitz, AA; Byrnes, K; Wynn, A; Farrell, K

    2014-01-01

    affect estimates of per capita costs. Methods. We analyzedestimates of per capita costs. METHODS At our request, theWhat was the annualized, per capita cost of HIV care for FFS

  18. Engineering of HIV gp120 by yeast surface display for neutralizing antibody characterization and immunogen design

    E-Print Network [OSTI]

    Mata-Fink, Jordi

    2013-01-01

    The sequence diversity of glycoprotein gp120 of the envelope spike of Human Immunodeficiency Virus (HIV) allows the virus to escape from antibody selection pressure. Certain conserved epitopes, like the CD4 binding site, ...

  19. De novo design and discovery of potent, nonpeptidal HIV-1 protease inhibitors

    SciTech Connect (OSTI)

    Lam, P.Y.S.; Eyermann, C.J.; Hodge, C.N.; Jadhav, P.K.; Ru, Yu; Bacheler, L.T.; Meek, J.L.; Otto, M.J.; Rayner, M.M.; Wong, N.Y.; Chang, C.H.; Weber, P.C.; Jackson, D.A.; Sharpe, T.R.; Erickson-Viitanen, S.K.

    1993-12-31

    Intense worldwide research in HIV-1 protease inhibition has resulted in many inhibitors with nanomolar Ki. However, they are mostly pseudopeptides (containing amide bonds) and substrate-like. In this work the authors report that using 3-D database searching, computer modeling and x-ray structures of the HIV-1 protease/inhibitor complex, a completely novel class of potent nonpeptides has been designed and synthesized. The Ki is in the subnanomolar range and the IC90 for the cell assays in the submicromolar range. Confirmation of the mode of binding was achieved by a high resolution x-ray structure of a HIV-1 protease/inhibitor complex. Molecular recognition studies between HIV-1 protease and these inhibitors will also be discussed.

  20. HIV Transmission Potential Among Local and Migrant Factory Workers in Kolkata, India

    E-Print Network [OSTI]

    Deb, Alok Kumar; Deb, Manjari; Saha, Malay Kumar; Chakraborty, Shantanu; Bhattacharya, Sujit Kumar; Detels, Roger

    2009-01-01

    of HIV in Andhra Pradesh, India. AIDS (London, England), 19(based female sex workers in India. BMC Public Health, 5, 87.migration of rural labour in India. Population Research and

  1. Two Sides of the Same Story: Alcohol Use and HIV Risk Taking in South India

    E-Print Network [OSTI]

    2010-01-01

    Andhra Pradesh and Calicut, Kerala. This project is takinga town of over 400,000 inhabitants in northern Kerala state.Kerala has been designated a moderate HIV prevalence state;

  2. Enhancement of HIV vaccine efficacy via lipid nanoparticle-based adjuvants

    E-Print Network [OSTI]

    Hanson, Melissa C. (Melissa Catherine)

    2015-01-01

    Adjuvants are immunomodulators and/or formulations/delivery vehicles which enhance immune responses to vaccines. The lack of progress in the development of an HIV humoral vaccine is due, in part, to the absence of available ...

  3. Spin models inferred from patient-derived viral sequence data faithfully describe HIV fitness landscapes

    E-Print Network [OSTI]

    Shekhar, Karthik

    Mutational escape from vaccine-induced immune responses has thwarted the development of a successful vaccine against AIDS, whose causative agent is HIV, a highly mutable virus. Knowing the virus' fitness as a function of ...

  4. Older Adults with HIV/AIDS: Experiences of Stigma-The Use of Personal Strengths

    E-Print Network [OSTI]

    Chandran, Devyani

    2009-12-08

    This dissertation explores the stigma experiences of older adults who have HIV/AIDS, the personal strengths and other responses they have to these experiences, and whether they experienced personal growth as a result of their responses to stigma. A...

  5. HIV entry : a biophysical and mutational analysis of gp41-mediated membrane fusion and its inhibition

    E-Print Network [OSTI]

    Suntoke, Tara R

    2005-01-01

    The experiments described in this thesis were designed to elucidate the manner in which the HIV-1 envelope protein (Env) initiates infection of host cells, and to develop inhibitors of viral entry. Env comprises two ...

  6. Economic growth, convergence and the HIV/AIDS epidemic: a cross-country panel data analysis 

    E-Print Network [OSTI]

    Smith, Joel Benjamin Edmund

    2011-07-05

    This thesis presents an analysis of the dynamic process of economic growth, national welfare and the HIV/AIDS epidemic. An assessment of the methodological designs of applied growth research is undertaken in order to ...

  7. RESEARCH ARTICLE Sexual Dimorphism in the Early

    E-Print Network [OSTI]

    Rutkowska, Joanna

    of sexual size dimorphism before gonadogenesis in birds. The finding suggests that faster growth of earlyRESEARCH ARTICLE Sexual Dimorphism in the Early Embryogenesis in Zebra Finches Makhsud Tagirov1 Citation: Tagirov M, Rutkowska J (2014) Sexual Dimorphism in the Early Embryogenesis in Zebra Finches. PLo

  8. CSU Early Childhood Center 2013 Annual Report

    E-Print Network [OSTI]

    with visiting international scholars in early childhood education, and the pivotal student learningCSU Early Childhood Center 2013 Annual Report #12;v Greetings from the Executive Director 2013 was an exciting and productive year for the Early Childhood Center at Colorado State University. We relocated

  9. Understanding aging in pentaerythritol tetranitrate

    SciTech Connect (OSTI)

    Brown, Geoffrey W; Sandstrom, Mary M; Giambra, Anna M; Archuleta, Jose G; Monroe, Deidre C

    2009-01-01

    Pentaerythritol Tetranitrate (PETN) powder is commonly used in detonators because of its sensitivity and explosive power. PETN detonation is largely determined by the average PETN particle size. This is an issue for aging and storage of weapons because PETN has a relatively high vapor pressure and its average particle size changes due to thermal energy input from the environment. PETN aging is a well known problem although the mechanism is not well understood. It is important to understand PETN aging so that predictive models can be constructed that will benefit stockpile surveillance and lifetime extension programs. PETN particles are known to coarsen over time at relatively low temperatures. Particle coarsening requires mass redistribution since decomposition causes powders to become finer as PETN mass is lost. Two possible mechanisms for mass redistribution are vapor phase transfer via sublimation-redeposition and solid-state mass transfer through surface diffusion. In this work we have examined PETN powders us ing permeability, atomic force microscopy (AFM), and optical microscopy based particle analysis. The results of these measurements lead us to a suggested coarsening mechanism that we reproduce with rudimentary simulations. The physical mechanisms used in the simulations are then used to create an empirical model of the coarsening that may be used to make predictions of PETN aging. In the future we will be measuring the vapor pressures and other physical properties of our powders to be able to make predictions using simulations.

  10. The Age of a Deer. 

    E-Print Network [OSTI]

    Ramsey, Charles W.; Shult, Milo J.

    1983-01-01

    of a Deer Charles W. Ramsey and Milo J. Shu/t Extension Wildlife Specialists The Texas A&M University System Tooth eruption and wear in deer are closely related to the age of the animal. Deer shed and replace milk teeth with permanent teeth at con...

  11. Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins

    DOE Patents [OSTI]

    Haynes, Barton F. (Durham, NC); Gao, Feng (Durham, NC); Korber, Bette T. (Los Alamos, NM); Hahn, Beatrice H. (Birmingham, AL); Shaw, George M. (Birmingham, AL); Kothe, Denise (Birmingham, AL); Li, Ying Ying (Hoover, AL); Decker, Julie (Alabaster, AL); Liao, Hua-Xin (Chapel Hill, NC)

    2011-12-06

    The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.

  12. Early detection of contagious diseases

    DOE Patents [OSTI]

    Colston, Jr., Billy W. (San Ramon, CA); Milanovich, Fred P. (Lafayette, CA); Estacio, Pedro (Mission San Jose, CA); Chang, John (Walnut Creek, CA)

    2011-08-09

    This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

  13. CASL OLCF Early Science Award

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room News PublicationsAudits &Bradbury Science Museum6 Shares Craig StevensOLCF Early Science

  14. Early Edison Users Deliver Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES Science Network Requirements Report ofEnergy and ClimateEarly

  15. Gandolfi wins Early Career Prize

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFESOpportunities Nuclear PhysicsGEGandolfi wins Early Career Prize

  16. SYNCHROTRON AGING IN FILAMENTED MAGNETIC FIELDS

    E-Print Network [OSTI]

    Eilek, Jean

    SYNCHROTRON AGING IN FILAMENTED MAGNETIC FIELDS J. A. EILEK 1;2 , D. B. MELROSE 2 and M.A. WALKER 2 radio sources whose dynamical ages are known to be significantly greater than the ages inferred from; In addition, it is becoming increasingly clear that radio galaxies suffer from an ``aging problem

  17. Neurocognitive Aging and the Compensation Hypothesis

    E-Print Network [OSTI]

    Neurocognitive Aging and the Compensation Hypothesis Patricia A. Reuter-Lorenz and Katherine A imaging studies of cognitive aging is evidence for age-related overactivation: greater acti- vation in older adults than in younger adults, even when performance is age-equivalent. Here we examine the hy

  18. Three Essays on the Economics of Education and Early Childhood

    E-Print Network [OSTI]

    Haimovich Paz, Francisco

    2015-01-01

    term Return to Early Childhood Education: Evidence From theterm Return to Early Childhood Education: Evidence From thePublic investment in early childhood education programs is

  19. A cultural communities approach to teacher early literacy practices

    E-Print Network [OSTI]

    Garrity, Sarah M.

    2011-01-01

    Eds. ), Yearbook in early childhood education, Vol. 4 (pp.1991) Redeveloping early childhood education: A response toJ. (2001). Early childhood education programs, Journal of

  20. Interdisciplinary Early Childhood Education (Birth-Kindergarten) 2013-14

    E-Print Network [OSTI]

    Acosta, Charles A.

    Curriculum Interdisciplinary Early Childhood Education (Birth-Kindergarten) 2013-14 Name ______________ ______________ __________________ Early Childhood Special Education Programs EDS 562 ______________ ______________ __________________ Current Trends in Early Childhood Education EDU 550

  1. Interdisciplinary Early Childhood Education (non-certification) 2013-14

    E-Print Network [OSTI]

    Acosta, Charles A.

    Curriculum Interdisciplinary Early Childhood Education (non-certification) 2013-14 Name ______________ ______________ __________________ Early Childhood Special Education Programs EDS 562 ______________ ______________ __________________ Current Trends in Early Childhood Education EDU 550

  2. Airlines & Aviation Alternative Fuels: Our Drive to Be Early...

    Energy Savers [EERE]

    Airlines & Aviation Alternative Fuels: Our Drive to Be Early Market Adopters Airlines & Aviation Alternative Fuels: Our Drive to Be Early Market Adopters Plenary III: Early Market...

  3. Incentivising safe sex: A randomised trial of conditional cash transfers for HIV and sexually transmitted infection prevention in rural Tanzania

    E-Print Network [OSTI]

    2012-01-01

    CCT for HIV/STI prevention in Tanzania related behaviors insurveillance system, Tanzania. In: Sankoh OA, Kahn K,infection prevention in rural Tanzania Damien de Walque, 1

  4. The role of non-formal education in combating the HIV epidemic in the Philippines and Taiwan

    E-Print Network [OSTI]

    Morisky, Donald E.; Lyu, Shu-Yu; Urada, Lianne A.

    2009-01-01

    indicators in Quezon City, Philippines. Journal of ClinicalNetwork (2007). Philippines HIV Initiatives database.Philippine National AIDS Council. http://

  5. Unraveling the paradoxes of HIV-associated psoriasis: A review of T-cell subsets and cytokine profiles

    E-Print Network [OSTI]

    Fife, Douglas J; Waller, Jeanette M; Jeffes, Edward W; Koo, John YM

    2007-01-01

    P. Related Articles, Links Psoriasis regression in terminalC, Koo JY. HIV and psoriasis. Clin Rev Allergy Immunol.Becker B, Berger TG. Psoriasis and human immunodeficiency

  6. Gaps in Ancillary Services among HIV-infected Substance Using Ryan-White Recipients in Los Angeles County

    E-Print Network [OSTI]

    Dierst-Davies, Rhodri David

    2015-01-01

    individuals' receipt of ancillary services and medical careR. (2009). More than ancillary: HIV social services,K. (2002). The impact of ancillary services on primary care

  7. Affinofile profiling: How efficiency of CD4/CCR5 usage impacts the biological and pathogenic phenotype of HIV

    E-Print Network [OSTI]

    Levine, Alex J.

    phenotype of HIV Kelechi Chikere a , Tom Chou b,c , Paul R. Gorry d,e,f , Benhur Lee a,c,g,n a Department

  8. The role of lysine 186 in HIV-1 integrase multimerization

    SciTech Connect (OSTI)

    Berthoux, Lionel [Department of Microbiology, Columbia University, New York (United States); Sebastian, Sarah [Department of Microbiology, Columbia University, New York (United States); Muesing, Mark A. [Aaron Diamond AIDS Research Center, Rockefeller University, New York (United States); Luban, Jeremy [Department of Microbiology, Columbia University, New York (United States) and Department of Medicine, Columbia University, New York (United States) and Institute for Research in Biomedicine, Bellinzona (Switzerland)]. E-mail: luban@irb.unisi.ch

    2007-07-20

    HIV-1 integrase (IN) catalyzes biochemical reactions required for viral cDNA insertion into host cell chromosomal DNA, an essential step in the HIV-1 replication cycle. In one of these reactions, the two ends of the linear viral cDNA are believed to be simultaneously ligated to chromosomal DNA by a tetrameric form of IN. The structure of the full-length IN tetramer is not known but a model consisting of the N-terminal domain and the catalytic core revealed basic residues 186 to 188 at the interface between the two IN dimers. We found that alteration of these residues, in particular changing IN lysine residue 186 to glutamate (K186Q), impairs IN oligomerization in the yeast two-hybrid system and decreases oligomeric forms of IN within virions. When expressed independently of other viral proteins in human cells, IN-K186Q did not concentrate in the nucleus as did wild-type IN. Co-expression of wild-type IN restored the multimerization defects of IN-K186Q, in both the two-hybrid system and in virions, and also rescued the nuclear targeting defects. Virions bearing IN-K186Q were not infectious in a single cycle of replication but when mixed virions containing two different IN mutants were produced, IN-K186Q was capable of complementing the catalytically inactive mutant IN-D116A. Our biochemical and functional data support the crystallographic model in which IN residue K186 lies at the interface between IN dimers and suggest that tetramerization is important, not only for concerted integration, but also for IN nuclear targeting.

  9. The Age of Beta Pic

    E-Print Network [OSTI]

    D. Barrado y Navascues; J. R. Stauffer; I. Song; J-P. Caillault

    1999-05-19

    We have reanalyzed data for the proposed moving group associated with beta Pic in order to determine if the group (or part of it) is real, and, if so, to derive an improved age estimate for beta Pic. By using new, more accurate proper motions from PPM and Hipparcos and a few new radial velocities, we conclude that on kinematic grounds, two M dwarfs have space motions that coincide with that of beta Pic to within 1 km/s with small error bars. Based on a CM diagram derived from accurate photometry and Hipparcos parallaxes, these two possible proper-motion companions to beta Pic are very young; we derive an age of $\\sim$20 Myr by comparison to theoretical tracks from D'Antona & Mazzitelli. In fact, the proposed beta Pic companions comprise two of the three youngest M dwarfs in the sample of 160 dM stars for which we have data. The chromospheric and coronal activity of these two stars also confirm that they are quite young. We argue that the probability that two of the three youngest nearby M dwarfs would accurately share the space motion of beta Pic by chance is quite small, and therefore we believe that beta Pic and the two M dwarfs (GL 799 and GL 803) were formed together. The estimated age for beta Pic is then 20$\\pm$10 Myr.

  10. The effect of Abstinence, Being faithful to one partner, and Condom use (ABC) messages on HIV infection among youth in Uganda

    E-Print Network [OSTI]

    Ekwaru, John Paul

    2012-01-01

    of Health (MOH) [Uganda] and ORC Macro Uganda HIV/AIDS Sero-USA: Ministry of Health and ORC Macro, 2006. 7. Harrison A,of Health (MOH) [Uganda] and ORC Macro Uganda HIV/AIDS Sero-

  11. Neural Effects of Beta Amyloid in Normal Aging

    E-Print Network [OSTI]

    Mormino, Elizabeth Charlotte

    2011-01-01

    age   categories.  Neurobiol  Aging  1997;  18:  351-­?7.  JK,  McIntosh  AR.  Aging  gracefully:  compensatory  B.  The  effect  of  normal  aging  on  the  coupling  of  

  12. Book: Aging and Oxidants in Animals and Plants Aging and oxidants in the nematode Caenorhabditis elegans

    E-Print Network [OSTI]

    Gems, David

    Book: Aging and Oxidants in Animals and Plants Aging and oxidants in the nematode Caenorhabditis;1.1 Testing the oxidative damage theory of aging in C. elegans The biology of aging remains poorly understood. For example, it remains unclear what sort of biological processes are the primary determinants of aging

  13. Aging discrepancies of white spruce affect the interpretation of static age structure in boreal

    E-Print Network [OSTI]

    Macdonald, Ellen

    NOTE Aging discrepancies of white spruce affect the interpretation of static age structure. Our objectives were to determine whether ground-level ring counts underestimate root collar age of understory P. glauca and whether aging errors increase with stand age. Trees were collected from one to nine

  14. Freezing Out Early Dark Energy

    E-Print Network [OSTI]

    Jannis Bielefeld; W. L. Kimmy Wu; Robert R. Caldwell; Olivier Dore

    2013-05-09

    A phenomenological model of dark energy that tracks the baryonic and cold dark matter at early times but resembles a cosmological constant at late times is explored. In the transition between these two regimes, the dark energy density drops rapidly as if it were a relic species that freezes out, during which time the equation of state peaks at +1. Such an adjustment in the dark energy density, as it shifts from scaling to potential-domination, could be the signature of a trigger mechanism that helps explain the late-time cosmic acceleration. We show that the non-negligible dark energy density at early times, and the subsequent peak in the equation of state at the transition, leave an imprint on the cosmic microwave background anisotropy pattern and the rate of growth of large scale structure. The model introduces two new parameters, consisting of the present-day equation of state and the redshift of the freeze-out transition. A Monte Carlo Markov Chain analysis of a ten-dimensional parameter space is performed to compare the model with pre-Planck cosmic microwave background, large scale structure and supernova data and measurements of the Hubble constant. We find that the transition described by this model could have taken place as late as a redshift z~400. We explore the capability of future cosmic microwave background and weak lensing experiments to put tighter constraints on this model. The viability of this model may suggest new directions in dark-energy model building that address the coincidence problem.

  15. Aging of Pentaerythritol Tetranitrate (PETN)

    SciTech Connect (OSTI)

    Foltz, M F

    2009-04-22

    Pentaerythritol tetranitrate (PETN) is a relatively sensitive explosive used in many electroexplosive devices as well as in medicine. Of primary interest to LLNL is its use in items such as exploding bridgewire (EBW) detonators and exploding bridge foil initiators (EFI). In these devices the crystalline powder is pressed into a granular, low-density compact that can be initiated by an exploding wire or foil. The long-term stability of this pressed compact is of interest to weapon stockpile lifetime prediction studies. Key points about potential aging mechanisms can be summarized as follows: (1) There are a number of factors that can contribute to PETN instability. These include particle size, polymorphic phase transitions, crystal structure, impurities, moisture, occlusions, chemical incompatibility and biological (microorganism) action. of these factors the most important for long-term aging of high surface area powders used in detonators appears to be that of particle size growth. (2) There is a great deal of literature on the thermal degradation kinetics of PETN, unfortunately much of it with little bearing on ambient temperature aging during long-term storage. PETN is very stable with respect to thermal decomposition. Low-temperature thermal studies have not revealed evidence of chemical degradation products in archived PETN. Data extrapolated to 30 C predicts a half-life of 12 million years. (3) Moisture seems to lower the activation energy for and accelerate the decomposition of PETN. (4) External drivers affecting stability include temperature, moisture, radiation fields, and stress, while internal drivers include residual solvents, and impurities. Temperature affects kinetic processes of crystal growth such as adsorption, desorption, and diffusion rates of molecules on the surface of PETN crystals. A low-level radiation field may induce unexpected changes in the chemical makeup of PETN and its homologue impurities. Stress at high pressure points caused by crystalline surface irregularities may cause a decrease in surface area over time due to smoothing of contact points and sintering. PETN has been found to contain a number of impurities, including homologues, pentaerythryl ethers with a mixture of hydroxyl and nitrate functional groups, and organic salts, that can alter its physical and chemical properties. (5) The processes of sublimation/recrystallization and surface diffusion are important processes that can cause changes in PETN crystal morphology, particle size distribution and specific surface area. Sublimation feeds a process called Ostwald ripening, which involves the spontaneous growth of larger crystals from those of smaller size. This process proceeds with age regardless of storage conditions unless the crystals are treated to retard growth. The coarsening mechanisms include Ostwald ripening, 'sintering', and surface diffusion. The latter has not been experimentally observed, but a molecular modeling approach has attempted to investigate this phenomenon theoretically. (6) Threshold test fire, particle size distribution, specific surface area, thermal analysis, chemical analysis, powder compact specific surface area and density are approaches that have been used in the attempt to assess changes attributable to aging of PETN, with varying results. The biggest problem lies in the aging mechanism itself, which likely influences small changes in morphology, both internal and external, and particle size distribution changes on a scale too small to reliably monitor. Other aspects, such as subtle changes in density profiles within pressed powder compacts, may be beyond the capability of current technology to assess. Crystal growth significant enough to affect the PETN particle size distribution is expected to impact detonator performance. (7) Factors relevant to stabilizing particle size growth include crystal morphology, powder surface area and particle size distribution; crystal density and internal defects; and powder compact density and density gradients.

  16. SNF AGING SYSTEM DESCRIPTION DOCUMENT

    SciTech Connect (OSTI)

    L.L. Swanson

    2005-04-06

    The purpose of this system description document (SDD) is to establish requirements that drive the design of the spent nuclear fuel (SNF) aging system and associated bases, which will allow the design effort to proceed. This SDD will be revised at strategic points as the design matures. This SDD identifies the requirements and describes the system design, as it currently exists, with emphasis on attributes of the design provided to meet the requirements. This SDD is an engineering tool for design control; accordingly, the primary audience and users are design engineers. This SDD is part of an iterative design process. It leads the design process with regard to the flow down of upper tier requirements onto the system. Knowledge of these requirements is essential in performing the design process. The SDD follows the design with regard to the description of the system. The description provided in the SDD reflects the current results of the design process. Throughout this SDD, the term aging cask applies to vertical site-specific casks and to horizontal aging modules. The term overpack is a vertical site-specific cask that contains a dual-purpose canister (DPC) or a disposable canister. Functional and operational requirements applicable to this system were obtained from ''Project Functional and Operational Requirements'' (F&OR) (Curry 2004 [DIRS 170557]). Other requirements that support the design process were taken from documents such as ''Project Design Criteria Document'' (PDC) (BSC 2004 [DES 171599]), ''Site Fire Hazards Analyses'' (BSC 2005 [DIRS 172174]), and ''Nuclear Safety Design Bases for License Application'' (BSC 2005 [DIRS 171512]). The documents address requirements in the ''Project Requirements Document'' (PRD) (Canori and Leitner 2003 [DIRS 166275]). This SDD includes several appendices. Appendix A is a Glossary; Appendix B is a list of key system charts, diagrams, drawings, lists and additional supporting information; and Appendix C is a list of procedures that will be used to operate the system.

  17. Early Childhood CARES Excited for 2013-2014 School Year

    E-Print Network [OSTI]

    ://earlychildhoodcares.uoregon.edu Early Childhood CARES provides early intervention and early childhood special education to all childrenEarly Childhood CARES Excited for 2013-2014 School Year Early Childhood CARES returned from its summer break with its motors tuned and ready to roll for the 2013-2014 school year! Early Childhood CARES

  18. Isochronal age scale of young moving groups in the solar neighbourhood

    E-Print Network [OSTI]

    Bell, Cameron P M; Naylor, Tim

    2015-01-01

    We present a self-consistent, absolute isochronal age scale for young (< 200 Myr), nearby (< 100 pc) moving groups, which is consistent with recent lithium depletion boundary ages for both the Beta Pic and Tucana-Horologium moving groups. This age scale was derived using a set of semi-empirical pre-main-sequence model isochrones that incorporate an empirical colour-Teff relation and bolometric corrections based on the observed colours of Pleiades members, with theoretical corrections for the dependence on log g. Absolute ages for young, nearby groups are vital as these regions play a crucial role in our understanding of the early evolution of low- and intermediate-mass stars, as well as providing ideal targets for direct imaging and other measurements of dusty debris discs, substellar objects and, of course, extrasolar planets.

  19. The New Biology of Ageing A Revolution in Ageing: The New Biology of Ageing and its Implications

    E-Print Network [OSTI]

    Gems, David

    The New Biology of Ageing 1 A Revolution in Ageing: The New Biology of Ageing and its Implications? Philosophische und biowissenschaftliche Perspektiven"(Longer Life: Biological, Medical and Philosophical Perspectives). Eds: Sebastian Knell, Marcel Weber. Surhkamp Verlag, 2009. Summary Until recently the biology

  20. Evaluation of Role of Oxidative Stress and Aging in Caenorhabditis elegans: Relevance to Human Aging

    E-Print Network [OSTI]

    Bondy, Stephen Bondy C

    2013-01-01

    vivo but do not retard aging in the nematode Caenorhabditiscyclooxygenase-2 activity. Aging Cell 2011; 10(3): 506-19.in wild-type and premature aging C. elegans mutant (mev-1) [

  1. Oxidative Stress and Aging in Caenorhabditis elegans: Relevance to Human Aging

    E-Print Network [OSTI]

    Bondy, Stephen Bondy C

    2013-01-01

    vivo but do not retard aging in the nematode Caenorhabditiscyclooxygenase-2 activity. Aging Cell 2011; 10(3): 506-19.in wild-type and premature aging C. elegans mutant (mev-1) [

  2. Role of Oxidative Stress and Aging in Caenorhabditis elegans: Relevance to Human Aging

    E-Print Network [OSTI]

    Bondy, Stephen Bondy C

    2013-01-01

    vivo but do not retard aging in the nematode Caenorhabditiscyclooxygenase-2 activity. Aging Cell 2011; 10(3): 506-19.in wild-type and premature aging C. elegans mutant (mev-1) [

  3. Library versus Library Recognition and Inhibition of the HIV-1 Nef Allelome Allison Olszewski and Gregory A. Weiss*,,

    E-Print Network [OSTI]

    Weiss, Gregory A.

    Library versus Library Recognition and Inhibition of the HIV-1 Nef Allelome Allison Olszewski resistance. Targeting HIV Nef with small molecules screened against a combinatorial library of Nef variants studies. We asked whether a library versus library approach could simultaneously uncover structure

  4. Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zhu, Xiaojie; Zhu, Yun; Ye, Sheng; Wang, Qian; Xu, Wei; Su, Shan; Sun, Zhiwu; Yu, Fei; Liu, Qi; Wang, Chao; et al

    2015-08-19

    Enfuvirtide (T20), is the first HIV fusion inhibitor approved for treatment of HIV/AIDS patients who fail to respond to the current antiretroviral drugs. However, its clinical application is limited because of short half-life, drug resistance and cross-reactivity with the preexisting antibodies in HIV-infected patients. Using an artificial peptide strategy, we designed a peptide with non-native protein sequence, AP3, which exhibited potent antiviral activity against a broad spectrum of HIV-1 strains, including those resistant to T20, and had remarkably longer in vivo half-life than T20. While the preexisting antibodies in HIV-infected patients significantly suppressed T20’s antiviral activity, these antibodies neither recognizedmore »AP3, nor attenuated its anti-HIV-1 activity. Structurally different from T20, AP3 could fold into single-helix and interact with gp41 NHR. The two residues, Met and Thr, at the N-terminus of AP3 form a hook-like structure to stabilize interaction between AP3 and NHR helices. Therefore, AP3 has potential for further development as a new HIV fusion inhibitor with improved antiviral efficacy, resistance profile and pharmacological properties over enfuvirtide. Meanwhile, this study highlighted the advantages of artificially designed peptides, and confirmed that this strategy could be used in developing artificial peptide-based viral fusion inhibitors against HIV and other enveloped viruses.« less

  5. Structure-Based Design of Novel HIV-1 Protease Inhibitors to Combat Drug Resistance

    SciTech Connect (OSTI)

    Ghosh,A.; Sridhar, P.; Leshchenko, S.; Hussain, A.; Li, J.; Kovalevsky, A.; Walters, D.; Wedelind, J.; Grum-Tokars, V.; et al.

    2006-01-01

    Structure-based design and synthesis of novel HIV protease inhibitors are described. The inhibitors are designed specifically to interact with the backbone of HIV protease active site to combat drug resistance. Inhibitor 3 has exhibited exceedingly potent enzyme inhibitory and antiviral potency. Furthermore, this inhibitor maintains impressive potency against a wide spectrum of HIV including a variety of multi-PI-resistant clinical strains. The inhibitors incorporated a stereochemically defined 5-hexahydrocyclopenta[b]furanyl urethane as the P2-ligand into the (R)-(hydroxyethylamino)sulfonamide isostere. Optically active (3aS,5R,6aR)-5-hydroxy-hexahydrocyclopenta[b]furan was prepared by an enzymatic asymmetrization of meso-diacetate with acetyl cholinesterase, radical cyclization, and Lewis acid-catalyzed anomeric reduction as the key steps. A protein-ligand X-ray crystal structure of inhibitor 3-bound HIV-1 protease (1.35 Angstroms resolution) revealed extensive interactions in the HIV protease active site including strong hydrogen bonding interactions with the backbone. This design strategy may lead to novel inhibitors that can combat drug resistance.

  6. Countering Aging Effects through Field Gate Sizing 

    E-Print Network [OSTI]

    Henrichson, Trenton D.

    2010-01-14

    Transistor aging through negative bias temperature instability (NBTI) has become a major lifetime constraint in VLSI circuits. We propose a technique that uses antifuses to widen PMOS transistors later in a circuit?s life cycle to combat aging...

  7. Utah Commission on Aging June 6, 2007

    E-Print Network [OSTI]

    Tipple, Brett

    Institutions Norma Matheson Chair Anne Peterson University of Utah Mayor JoAnn Seghini Midvale City Sara to the Commission for consideration. · Aging SMART: Denise Brooks distributed Aging SMART Sourcebook. Website is up

  8. 6, 39453963, 2006 Methanol inside aged

    E-Print Network [OSTI]

    ACPD 6, 3945­3963, 2006 Methanol inside aged tropical biomass burning plumes G. Dufour et al. Title Chemistry and Physics Discussions First space-borne measurements of methanol inside aged tropical biomass. Dufour (gaelle.dufour@lmd.polytechnique.fr) 3945 #12;ACPD 6, 3945­3963, 2006 Methanol inside aged

  9. HYGROTHERMAL AGING OF POLYIMIDE MATRIX COMPOSITE LAMINATES

    E-Print Network [OSTI]

    Nairn, John A.

    HYGROTHERMAL AGING OF POLYIMIDE MATRIX COMPOSITE LAMINATES John A. Nairn and Man-Hee Han Materials-0560, USA SUMMARY: Two polyimide-matrix systems were subjected to a series of hygrothermal aging experiments at various temperatures and relative humidities. For each aging condition, we measured the microcracking

  10. Dry aging beef for the retail channel 

    E-Print Network [OSTI]

    Smith, Robert David

    2007-09-17

    USDA Choice (n=48) and Select (n=48) paired Beef Loin, Short Loins, Short Cut (IMPS #174) were separated randomly into one of two treatments, dry or wet aging, and were aged for 14, 21, 28, or 35 d. At the end of each aging period, short loins were...

  11. FORUM REVIEW ARTICLE Alternative Perspectives on Aging

    E-Print Network [OSTI]

    Gems, David

    FORUM REVIEW ARTICLE Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen mechanisms at the heart of the aging process are a long-standing mystery. An influential theory has it that aging is the result of an accumulation of molecular damage, caused in particular by reactive oxygen

  12. aging,Bioengineering, AcousticsCircuitsand

    E-Print Network [OSTI]

    Lee, Tonghun

    Biom edicalIm aging,Bioengineering, AcousticsCircuitsand SignalProcessing Com m unicationsand) #12;Biom edicalIm aging,Bioengineering, Acoustics Circuitsand SignalProcessing Com m unicationsand. M. L. Oelze T. J. Overbye ELECTRICAL AND COMPUTER ENGINEERING (2 OF 3) #12;Biom edicalIm aging,Bioengineering

  13. Noncommutativity in the early Universe

    E-Print Network [OSTI]

    G. Oliveira-Neto; M. Silva de Oliveira; G. A. Monerat; E. V. Corrêa Silva

    2014-12-18

    In the present work, we study the noncommutative version of a quantum cosmology model. The model has a Friedmann-Robertson-Walker geometry, the matter content is a radiative perfect fluid and the spatial sections have zero constant curvature. In this model the scale factor takes values in a bounded domain. Therefore, its quantum mechanical version has a discrete energy spectrum. We compute the discrete energy spectrum and the corresponding eigenfunctions. The energies depend on a noncommutative parameter $\\beta$. We compute the scale factor expected value ($\\leftright>$) for several values of $\\beta$. For all of them, $\\leftright>$ oscillates between maxima and minima values and never vanishes. It gives an initial indication that those models are free from singularities, at the quantum level. The $\\leftright>$ behavior, for the present model, is a drastic modification of the $\\leftright>$ behavior in the corresponding commutative version of the present model. There, $\\leftright>$ grows without limits with the time variable. Therefore, if the present model may represent the early stages of the Universe, the results of the present paper give an indication that $\\leftright>$ may have been, initially, bounded due to noncommutativity.

  14. Cooperation Enablement for Centralistic Early Warning Systems

    E-Print Network [OSTI]

    Flegel, Ulrich

    Cooperation Enablement for Centralistic Early Warning Systems Ulrich Flegel SAP Research CEC that is considered here is the centralistic malware early warning system developed in the AMSEL project [3 Karlsruhe Vincenz-Prießnitz-Str. 1 76131 Karlsruhe, Germany ulrich.flegel@sap.com Johannes Hoffmann TU

  15. Whooping Cough Be Aware. Treat It Early.

    E-Print Network [OSTI]

    Puha, Amber

    Cough Be Aware. Treat It Early. What Is Whooping Cough? · Whooping cough disease (also called pertussis) causes coughing fits that make it hard to breathe. · It spreads easily when someone with the disease coughs or sneezes. · It can kill young babies. Whooping Cough Signs and Symptoms Early Symptoms Often

  16. Verifiable early-reply with C++ 

    E-Print Network [OSTI]

    Cook, Stephen Wendell

    2007-09-17

    . ................................................................................ 15 Figure 6. Early-Reply's material and residual segment. .............................................................. 21 Figure 7. Simple example of Early-Reply code........................................................................... 22... is a popular research area. The main reasons for wanting an application to run faster are: 1) The program’s total execution time needs to be improved (throughput). 2) Certain program segments require a faster response (response time...

  17. To receive the Early Childhood Minor and the Early Childhood Endorsement one Must

    E-Print Network [OSTI]

    Berdichevsky, Victor

    contacts, TED 5790 at the College of Education Early Childhood Center at University Towers and TED 5780 Dittenber or Mr. John Radke; for appointments call (313)577-0915 Elementary Education / Early Childhood) Elementary Education Early Childhood Education This program is designed for individuals with a bachelor

  18. Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

    SciTech Connect (OSTI)

    Wu, Xueling; Zhou, Tongqing; Zhu, Jiang; Zhang, Baoshan; Georgiev, Ivelin; Wang, Charlene; Chen, Xuejun; Longo, Nancy S.; Louder, Mark; McKee, Krisha; O’ Dell, Sijy; Perfetto, Stephen; Schmidt, Stephen D.; Shi, Wei; Wu, Lan; Yang, Yongping; Yang, Zhi-Yong; Yang, Zhongjia; Zhang, Zhenhai; Bonsignori, Mattia; Crump, John A.; Kapiga, Saidi H.; Sam, Noel E.; Haynes, Barton F.; Simek, Melissa; Burton, Dennis R.; Koff, Wayne C.; Doria-Rose, Nicole A.; Connors, Mark; Mullikin, James C.; Nabel, Gary J.; Roederer, Mario; Shapiro, Lawrence; Kwong, Peter D.; Mascola, John R. (Tumaini); (NIH); (Duke); (Kilimanjaro Repro.); (IAVI)

    2013-03-04

    Antibody VRC01 is a human immunoglobulin that neutralizes about 90% of HIV-1 isolates. To understand how such broadly neutralizing antibodies develop, we used x-ray crystallography and 454 pyrosequencing to characterize additional VRC01-like antibodies from HIV-1-infected individuals. Crystal structures revealed a convergent mode of binding for diverse antibodies to the same CD4-binding-site epitope. A functional genomics analysis of expressed heavy and light chains revealed common pathways of antibody-heavy chain maturation, confined to the IGHV1-2*02 lineage, involving dozens of somatic changes, and capable of pairing with different light chains. Broadly neutralizing HIV-1 immunity associated with VRC01-like antibodies thus involves the evolution of antibodies to a highly affinity-matured state required to recognize an invariant viral structure, with lineages defined from thousands of sequences providing a genetic roadmap of their development.

  19. Landscapes of settlement in South-East Cyprus the late Bronze Age origins of a Phoenician polity incorporating the results of fieldwork by the author at Pyla-Kokkinokremos 2007-2009 

    E-Print Network [OSTI]

    Brown, Michael Gareth

    2012-06-28

    The origins of Early Iron Age polity in south-east Cyprus have traditionally been attributed to the formal imposition of Phoenician dominion over Kition in 707 BC. It is proposed that this paradigm fails adequately to ...

  20. Allegre, C.J., Manhes, G., Gopel, C. 1995: The age of the Earth, Geochim. Cosmochim. Acta 59, 1445

    E-Print Network [OSTI]

    Ulmschneider, Peter

    , Astron. Astrophys. 299, 755 Bowring, S.A., Williams, I.S. 1999: Priscoan (4.00-4.03 Ga) orthogneisses., Connelly, J., Henning, H. 2005: Early planetesimal melting from an age of 4.5662 Gyr for di erentiated mete

  1. PUBLISHED ONLINE: 23 FEBRUARY 2014 | DOI: 10.1038/NGEO2075 Hadean age for a post-magma-ocean zircon

    E-Print Network [OSTI]

    Meyers, Stephen R.

    backscatter diffraction (EBSD), and analysed by SIMS in 10­20-µm-diameter spots to determine its age, oxygen of crustal growth, tectonics, surface conditions and possible habitats for life on early Earth2 events, respectively. Emission of -particles causes low concentrations of atomic displacements along 10

  2. HIV/AIDS Information Resources from the National Library of Medicine-STOP

    SciTech Connect (OSTI)

    Templin-Branner, W. and N. Dancy

    2010-06-15

    The HIV/AIDS Information Resources from the National Library of Medicine training is designed specifically for the UNCFSP HBCU Screening, Testing, Outreach, and Prevention (STOP) HIV/AIDS Program project members to provide valuable health information resources from the National Library of Medicine and other reliable sources to increase awareness of the wealth of treatment information and educational materials that are available on the Internet and to improve prevention and treatment education for their clients. These resources will also meet the needs of community-based organizations

  3. AGING PERFORMANCE OF MODEL 9975 PACKAGE FLUOROELASTOMER O-RINGS

    SciTech Connect (OSTI)

    Hoffman, E.; Daugherty, W.; Skidmore, E.; Dunn, K.; Fisher, D.

    2011-05-31

    The influence of temperature and radiation on Viton{reg_sign} GLT and GLT-S fluoroelastomer O-rings is an ongoing research focus at the Savannah River National Laboratory. The O-rings are credited for leaktight containment in the Model 9975 shipping package used for transportation of plutonium-bearing materials. At the Savannah River Site, the Model 9975 packages are being used for interim storage. Primary research efforts have focused on surveillance of O-rings from actual packages, leak testing of seals at bounding aging conditions and the effect of aging temperature on compression stress relaxation behavior, with the goal of service life prediction for long-term storage conditions. Recently, an additional effort to evaluate the effect of aging temperature on the oxidation of the materials has begun. Degradation in the mechanical properties of elastomers is directly related to the oxidation of the polymer. Sensitive measurements of the oxidation rate can be performed in a more timely manner than waiting for a measurable change in mechanical properties, especially at service temperatures. Measuring the oxidation rate therefore provides a means to validate the assumption that the degradation mechanisms(s) do not change from the elevated temperatures used for accelerated aging and the lower service temperatures. Monitoring the amount of oxygen uptake by the material over time at various temperatures can provide increased confidence in lifetime predictions. Preliminary oxygen consumption analysis of a Viton GLT-based fluoroelastomer compound (Parker V0835-75) using an Oxzilla II differential oxygen analyzer in the temperature range of 40-120 C was performed. Early data suggests oxygen consumption rates may level off within the first 100,000 hours (10-12 years) at 40 C and that sharp changes in the degradation mechanism (stress-relaxation) are not expected over the temperature range examined. This is consistent with the known long-term heat aging resistance of fluoroelastomers relative to hydrocarbon-based elastomers, and in absence of antioxidants that may be consumed over time. Additional experimental effort will be undertaken in the short term range within the first 100 hours of thermal aging to capture further details of the oxygen consumption rate.

  4. The natural history of telomeres: tools for aging animals and exploring the aging process

    E-Print Network [OSTI]

    Vleck, Carol

    The natural history of telomeres: tools for aging animals and exploring the aging process Carol M, IA 50014, USA Abstract We have been exploring the use of telomere length as a technique to age animals. If telomere restriction fragments (TRFs) shorten predictably with age in a particular tissue

  5. Radiation Therapy for Neovascular Age-related Macular Degeneration

    SciTech Connect (OSTI)

    Kishan, Amar U.; Modjtahedi, Bobeck S.; Morse, Lawrence S.; Lee, Percy

    2013-03-01

    In the enormity of the public health burden imposed by age-related macular degeneration (ARMD), much effort has been directed toward identifying effective and efficient treatments. Currently, anti-vascular endothelial growth factor (VEGF) injections have demonstrated considerably efficacy in treating neovascular ARMD, but patients require frequent treatment to fully benefit. Here, we review the rationale and evidence for radiation therapy of ARMD. The results of early photon external beam radiation therapy are included to provide a framework for the sequential discussion of evidence for the usage of stereotactic radiation therapy, proton therapy, and brachytherapy. The evidence suggests that these 3 modern modalities can provide a dose-dependent benefit in the treatment of ARMD. Most importantly, preliminary data suggest that all 3 can be used in conjunction with anti-VEGF therapeutics, thereby reducing the frequency of anti-VEGF injections required to maintain visual acuity.

  6. Assistant/Associate Professor, Early Childhood ELL Education Job # 10837

    E-Print Network [OSTI]

    Shumway, John

    Assistant/Associate Professor, Early Childhood ELL Education Job # 10837 At Arizona State of research and scholarship in the field of early childhood/early childhood special education/BLE/ESL, and will have opportunities to collaborate with nationally recognized faculty in early childhood education/early

  7. Characterization of Field-Aged Exhaust Gas Recirculation Cooler...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Field-Aged Exhaust Gas Recirculation Cooler Deposits Characterization of Field-Aged Exhaust Gas Recirculation Cooler Deposits Characterized field-aged exhaust gas recirculation...

  8. Local Land-Use Controls and Aging-Friendliness

    E-Print Network [OSTI]

    Rosenthal, Larry A.

    2009-01-01

    A. 2001. “Aging and Smart Growth: Building Aging-Sensitivebuilding such product exclusively, or predominantly, because it creates homogenous-age zones, defeats smart-

  9. Aging and Longevity after Photoperiod Induced Variations in Life History /

    E-Print Network [OSTI]

    Raiewski, Evan Eric

    2013-01-01

    predicts future outcomes in aging adults. J Geriatr Physprogramming of body size. Aging Cell, 9(4), Conti, B. ,thermoregulation and biological aging. Physiol Rev, 78(2),

  10. Understanding Aging: A Medical Humanities Approach to “Death in Venice“

    E-Print Network [OSTI]

    English, David

    2008-01-01

    issues, understanding aging from a humanistic perspective isattempting to understand aging, I have divided the text intoAschenbach's experience with aging while in Germany. This

  11. Blockade of chemokine-induced signalling inhibits CCR5-dependent HIV infection in vitrowithout blocking gp120/CCR5 interaction

    E-Print Network [OSTI]

    Grainger, David J.; Lever, Andrew M. L.

    2005-04-04

    the Potts Mini RT assay as previously described [32]. THP-1 cells were differentiated prior to infection with hydrocortisone and PMA in 8-well chamber slides. Sixteen hours prior to infection, TNF? was added (100 ng/ml). Twelve hours later, the medium... of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4. Antiviral Res 1997, 35:147-156. 32. Potts BJ: 'Mini' reverse transcriptase (RT) assay. In Techniques in HIV research Edited by: Aldovini A, Walker BD. New York: Stockton Press; 1990...

  12. Haptic holography : an early computational plastic

    E-Print Network [OSTI]

    Plesniak, Wendy J. (Wendy Jean)

    2001-01-01

    This dissertation introduces haptic holography, a combination of computational modeling and multimodal spatial display, as an early computationalplastic In this work, we combine various holographic displays with a force ...

  13. Monthly Weather Review EARLY ONLINE RELEASE

    E-Print Network [OSTI]

    Majda, Andrew J.

    Monthly Weather Review EARLY ONLINE RELEASE This is a preliminary PDF of the author Institute of Mathematical Sciences5 New York University6 New York, NY7 Submitted to Monthly Weather Review8

  14. Monthly Weather Review EARLY ONLINE RELEASE

    E-Print Network [OSTI]

    Collett Jr., Jeffrey L.

    Monthly Weather Review EARLY ONLINE RELEASE This is a preliminary PDF of the author to Monthly Weather Review25 Revised 16 May 201426 Manuscript (non-LaTeX) Click here to download Manuscript

  15. Extreme Genomics By Scouring the Genomes of 50 HIV-Resistant People, Study

    E-Print Network [OSTI]

    Dolbow, John

    Extreme Genomics By Scouring the Genomes of 50 HIV-Resistant People, Study Takes Aim at Rare Gene Genome Variation, and his colleagues think that the complete genome sequences of those fortunate few against the viral strain that usually infects humans. That's because the CCR5 protein is Extreme Genomics

  16. CTSHIV: A Knowledge-Based System For the Management of HIV-infected Patients

    E-Print Network [OSTI]

    Pazzani, Michael J.

    See Ranjit Iyer Edison Schroeder Jeremiah Tilles Department of Information & Computer Science has developed. By monitoringthe HIV virus of the patient, the treatment strategy can be switched in response to mutations of the virus. CTSHIV contains a knowledge base that encodes information from

  17. Distribution of Immune Cells in the Human Cervix and Implications for HIV Transmission

    E-Print Network [OSTI]

    Lieberman, Judy

    Distribution of Immune Cells in the Human Cervix and Implications for HIV Transmission Radiana T transmission. Am J Reprod Immunol 2014; 71: 252­264 doi:10.1111/aji.12198 Problem Knowledge of the mucosal a third were CD11c+ , most of which were CD103À CD11b+ CX3CR1+ DC-SIGN+ dendritic cells (DCs). The other

  18. Structural properties of the histidine-containing loop in HIV-1RNase H

    SciTech Connect (OSTI)

    Kern, G.; Pelton, J.; Marqusee, S.; Kern, D.

    2001-01-02

    The isolated HIV-1 RNase H domain is inactive. This inactivity has been linked to the lack of structure in the C-terminus of the isolated domain. His539 residing in a loop preceding the C-terminal Helix was studies by NMR to determine the stability and conformational properties of this region.

  19. Modeling within-host HIV-1 dynamics and the evolution of drug

    E-Print Network [OSTI]

    2007-07-25

    Apr 19, 2007 ... manage the evolution of drug resistance within a patient. The main ... describe the virus dynamics of HIV-1 infection in vivo (see. Perelson et ..... The steady state of the viral load is plotted as a function of ? or ?E in (c) and (d).

  20. The Fusion Activity of HIV-1 gp41 Depends on Interhelical Interactions*

    E-Print Network [OSTI]

    Chan, David

    The Fusion Activity of HIV-1 gp41 Depends on Interhelical Interactions* Received for publication, the transmem- brane subunit of the viral envelope protein. Crystallo- graphic studies have revealed that fusion and target membranes together, resulting in membrane fusion and viral entry. We test this hypothesis

  1. INCORPORATION OF VARIABILITY INTO THE MODELING OF VIRAL DELAYS IN HIV INFECTION DYNAMICS

    E-Print Network [OSTI]

    . Banks and D. M. Bortz1 Center for Research in Scientific Computation Box 8205, North Carolina State for the slow, progressive, and fatal Acquired Immune Deficiency Syndrome (AIDS). According to a Joint United]. HIV-related illness and death is and will continue to be an important clinical and public health issue

  2. INCORPORATION OF VARIABILITY INTO THE MODELING OF VIRAL DELAYS IN HIV INFECTION DYNAMICS

    E-Print Network [OSTI]

    . Banks and D. M. Bortz 1 Center for Research in Scientific Computation Box 8205, North Carolina State for the slow, progressive, and fatal Acquired Immune Deficiency Syndrome (AIDS). According to a Joint United]. HIV­related illness and death is and will continue to be an important clinical and public health issue

  3. Mathematical analysis of delay differential equation models of HIV-1 infection

    E-Print Network [OSTI]

    Bernard, Samuel

    in HIV-1 infected patients, minimal estimates of the death rate of productively infected cells, the rate that when the drug efficacy is less than perfect the estimated value of the loss rate of productively from experiments in which antiret- roviral drugs were given to perturb the dynamical state of infection

  4. Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach

    SciTech Connect (OSTI)

    Leitner, Thomas; Paraskevis, D; Pybus, O; Magiorkinis, G; Hatzakis, A

    2008-01-01

    The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from the perspective of the virus has not previously been traced. In the current study we inferred the migration history of HIV-1 subtype B by way of a phylogeography of viral sequences sampled from 16 European countries and Israel. Migration events were inferred from viral phylogenies by character reconstruction using parsimony. With regard to the spatial dispersal of the HIV subtype B sequences across viral phylogenies, in most of the countries in Europe the epidemic was introduced by multiple sources and subsequently spread within local networks. Poland provides an exception where most of the infections were the result of a single point introduction. According to the significant migratory pathways, we show that there are considerable differences across Europe. Specifically, Greece, Portugal, Serbia and Spain, provide sources shedding HIV-1; Austria, Belgium and Luxembourg, on the other hand, are migratory targets, while for Denmark, Germany, Italy, Israel, Norway, the Netherlands, Sweden, Switzerland and the UK we inferred significant bidirectional migration. For Poland no significant migratory pathways were inferred. Subtype B phylogeographies provide a new insight about the geographical distribution of viral lineages, as well as the significant pathways of virus dispersal across Europe, suggesting that intervention strategies should also address tourists, travellers and migrants.

  5. HIV/AIDS in African-Americans Christopher Evans, MD/MPH

    E-Print Network [OSTI]

    Chapman, Michael S.

    of Medicine Oregon Health and Science University #12;Disclosure I have no actual or potential conflict of interest in relation to this program/presentation #12;"Of all the forms of inequality, injustice in health in particular. 2005 Nationwide survey of African-Americans 26% believe HIV was made in a US government lab 15

  6. Standing Genetic Variation and the Evolution of Drug Resistance in HIV

    E-Print Network [OSTI]

    Standing Genetic Variation and the Evolution of Drug Resistance in HIV Pleuni Simone Pennings are available from literature, which allows us to estimate the probability that resistance evolves from standing due to standing genetic variation between 0 and 39%. For patients who start triple-drug combination

  7. Effects of main-sequence mass loss on the turnoff ages of globular clusters

    SciTech Connect (OSTI)

    Guzik, J.A.

    1989-01-01

    Willson, Bowen, and Struck-Marcell have proposed that globular cluster main-sequence turnoff ages can be reconciled with the lower ages of the Galaxy and universe deduced from other methods by incorporating an epoch of early main-sequence mass-loss by stars of spectral types A through early-F. The proposed mass loss is pulsation-driven, and facilitated by rapid rotation. This paper presents stellar evolution calculations of Pop. II (Z = 0.001) mass-losing stars of initial mass 0.8 to 1.6 M/sub /circle dot//, with exponentially-decreasing mass loss rates of e-folding times 0.5 to 2.0 Gyr, evolving to a final mass of 0.7 M/sub /circle dot//. The calculations indicate that a globular cluster with apparent turnoff age 18 Gyr could have an actual age as low as /approximately/12 Gyr. Observational implications that may help to verify the hypothesis, e.g. low C/N abundance ratios among red giants following first dredge-up, blue stragglers, red giant deficiencies, and signatures in cluster mass/luminosity functions, are also discussed.25 refs., 4 figs., 3 tabs.

  8. The Next ICE Age | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    More Documents & Publications The Next ICE Age Fuel Modification t Facilitate Future Combustion Regimes? Optimization of Advanced Diesel Engine Combustion Strategies...

  9. Immigration Control in the Age of Migration

    E-Print Network [OSTI]

    Wong, Tak Kei

    2011-01-01

    Policies for an Age of Migration. Washington D.C. : Carnegieed. ). 2011. Global Migration Governance. New York: OxfordCitizenship. ” International Migration Review 38 (2): 389-

  10. Aging and Radiation Effects in Stockpile Electronics

    SciTech Connect (OSTI)

    Hartman, E.F.

    1999-03-25

    It is likely that aging is affecting the radiation hardness of stockpile electronics, and we have seen apparent examples of aging that affects the electronic radiation hardness. It is also possible that low-level intrinsic radiation that is inherent during stockpile life will damage or in a sense age electronic components. Both aging and low level radiation effects on radiation hardness and stockpile reliability need to be further investigated by using both test and modeling strategies that include appropriate testing of electronic components withdrawn from the stockpile.

  11. Personal meanings of death among early adolescents 

    E-Print Network [OSTI]

    Fitch, Starla Dianne

    1978-01-01

    PERSONAL MEANINGS OF DEATH AMONG EARLY ADOLESCENTS A Thesis by Starla Dianne Fitch Submitted to the Graduate College of Texas A&M University in partial filfillment of the requirement for the degree of MASTER OF SCIENCE December, 1978 Major... Subject; Sociology PERSONAL MEANINGS OF DEATH AMONG EARLY ADOLESCENTS A Thesis by Starla Dianne Fitch Approved as to style and content by: (Chairman of Committee) / / / / J ea'd of Department) i (Member) mber) December, 1978 ABSTRACT...

  12. UMBC Department of Education Early Childhood Education Personnel Preparation Program

    E-Print Network [OSTI]

    Adali, Tulay

    UMBC Department of Education Early Childhood Education Personnel Preparation Program Procedures, Early Childhood Education Department of Education UMBC 1000 Hilltop Circle Baltimore, MD 21250 #12;UMBC DEPARTMENT OF EDUCATION EARLY CHILDHOOD PERSONNEL PREPARATION PROGRAM UNDERGRADUATE APPLICATION Present Date

  13. College of Education IEC Interdisciplinary Early Childhood Education

    E-Print Network [OSTI]

    MacAdam, Keith

    College of Education IEC Interdisciplinary Early Childhood Education KEY: # = new course * = course TO EARLY CHILDHOOD EDUCATION. (3) Anintroductiontothehistoryofearlychildhoodeducationandanoverviewofcurrentlawsandbestpractices.Discussionswillinclude issues impacting families and current research in early childhood education

  14. Completing an Honors Thesis in Teacher Education Early Childhood Education

    E-Print Network [OSTI]

    Olsen Jr., Dan R.

    Completing an Honors Thesis in Teacher Education Early Childhood Education Elementary Education to the major program, Early Childhood Education, Elementary Education, or Social Studies Education (which in the Department of Teacher Education (Early Childhood Education, Elementary Education, and Social Studies

  15. PROGRAM GUIDE BA IN EDUCATION SPECIALIZATION IN EARLY CHILDHOOD EDUCATION

    E-Print Network [OSTI]

    Rusu, Adrian

    PROGRAM GUIDE BA IN EDUCATION ­ SPECIALIZATION IN EARLY CHILDHOOD EDUCATION I. Benchmark Point 1 Communities II: Early Childhood (TLCII), and Educational Technology. G. Ratings of "Meets Expectations: Early Childhood, Educational Technology, Growth and Learning: Birth ­ 5 years, Language Development

  16. Incorporating safety risk in early system architecture trade studies

    E-Print Network [OSTI]

    Dulac, Nicholas

    Ideally, safety should be a part of the early decision making used in conceptual system design. However, effectively evaluating safety risk3 early enough to inform the early trade studies is not possible with current ...

  17. Distinctive microstructural features of aged sodium silicate-activated slag concretes

    SciTech Connect (OSTI)

    San Nicolas, Rackel; Bernal, Susan A.; Mejía de Gutiérrez, Ruby; Deventer, Jannie S.J. van; Provis, John L.

    2014-11-15

    Electron microscopic characterisation of 7-year old alkali-activated blast-furnace slag concretes enabled the identification of distinct microstructural features, providing insight into the mechanisms by which these materials evolve over time. Backscattered electron images show the formation of Liesegang-type ring formations, suggesting that the reaction at advanced age is likely to follow an Oswald supersaturation–nucleation–depletion cycle. Segregation of Ca-rich veins, related to the formation of Ca(OH){sub 2}, is observed in microcracked regions due to the ongoing reaction between the pore solution and available calcium from remnant slag grains. A highly dense and uniform interfacial transition zone is identified between siliceous aggregate particles and the alkali activated slag binders, across the concretes assessed. Alkali-activated slag concretes retain a highly dense and stable microstructure at advanced ages, where any microcracks induced at early ages seem to be partially closing, and the remnant slag grains continue reacting.

  18. For whom is "Successful Aging" Relevant?:(Re)defining the Aging Experience through the Voices of Hmong Elders

    E-Print Network [OSTI]

    Vang, Mai Yang

    2013-01-01

    GE and Mukamal K. “Successful aging. ” American Journal ofand cultural context of adaptive aging among Southeast AsianThe Cultural Context of Aging. New York: Greenwood,

  19. Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Liu, Donglai; Zuo, Tao; Hora, Bhavna; Song, Hongshuo; Kong, Wei; Yu, Xianghui; Goonetilleke, Nilu; Bhattacharya, Tanmoy; Perelson, Alan S.; Haynes, Barton F.; et al

    2014-01-01

    Background: Fitness costs and slower disease progression are associated with a cytolytic T lymphocyte (CTL) escape mutation T242N in Gag in HIV-1-infected individuals carrying HLA-B*57/5801 alleles. However, the impact of different context in diverse HIV-1 strains on the fitness costs due to the T242N mutation has not been well characterized. To better understand the extent of fitness costs of the T242N mutation and the repair of fitness loss through compensatory amino acids, we investigated its fitness impact in different transmitted/founder (T/F) viruses. Results: The T242N mutation resulted in various levels of fitness loss in four different T/F viruses. However, themore »fitness costs were significantly compromised by preexisting compensatory amino acids in (Isoleucine at position 247) or outside (glutamine at position 219) the CTL epitope. Moreover, the transmitted T242N escape mutant in subject CH131 was as fit as the revertant N242T mutant and the elimination of the compensatory amino acid I247 in the T/F viral genome resulted in significant fitness cost, suggesting the fitness loss caused by the T242N mutation had been fully repaired in the donor at transmission. Analysis of the global circulating HIV-1 sequences in the Los Alamos HIV Sequence Database showed a high prevalence of compensatory amino acids for the T242N mutation and other T cell escape mutations. Conclusions: Our results show that the preexisting compensatory amino acids in the majority of circulating HIV-1 strains could significantly compromise the fitness loss due to CTL escape mutations and thus increase challenges for T cell based vaccines.« less

  20. Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation

    SciTech Connect (OSTI)

    Liu, Donglai; Zuo, Tao; Hora, Bhavna; Song, Hongshuo; Kong, Wei; Yu, Xianghui; Goonetilleke, Nilu; Bhattacharya, Tanmoy; Perelson, Alan S.; Haynes, Barton F.; McMichael, Andrew J.; Gao, Feng

    2014-01-01

    Background: Fitness costs and slower disease progression are associated with a cytolytic T lymphocyte (CTL) escape mutation T242N in Gag in HIV-1-infected individuals carrying HLA-B*57/5801 alleles. However, the impact of different context in diverse HIV-1 strains on the fitness costs due to the T242N mutation has not been well characterized. To better understand the extent of fitness costs of the T242N mutation and the repair of fitness loss through compensatory amino acids, we investigated its fitness impact in different transmitted/founder (T/F) viruses. Results: The T242N mutation resulted in various levels of fitness loss in four different T/F viruses. However, the fitness costs were significantly compromised by preexisting compensatory amino acids in (Isoleucine at position 247) or outside (glutamine at position 219) the CTL epitope. Moreover, the transmitted T242N escape mutant in subject CH131 was as fit as the revertant N242T mutant and the elimination of the compensatory amino acid I247 in the T/F viral genome resulted in significant fitness cost, suggesting the fitness loss caused by the T242N mutation had been fully repaired in the donor at transmission. Analysis of the global circulating HIV-1 sequences in the Los Alamos HIV Sequence Database showed a high prevalence of compensatory amino acids for the T242N mutation and other T cell escape mutations. Conclusions: Our results show that the preexisting compensatory amino acids in the majority of circulating HIV-1 strains could significantly compromise the fitness loss due to CTL escape mutations and thus increase challenges for T cell based vaccines.

  1. Early Markets: Fuel Cells for Backup Power | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Early Markets: Fuel Cells for Backup Power Early Markets: Fuel Cells for Backup Power This fact sheet describes the advantages of using fuel cell technology for application in...

  2. Early Markets: Fuel Cells for Material Handling Equipment | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Early Markets: Fuel Cells for Material Handling Equipment Early Markets: Fuel Cells for Material Handling Equipment This fact sheet describes the use of hydrogen fuel cells to...

  3. The International Biogeography Society Early Career Conference 2014

    E-Print Network [OSTI]

    2013-01-01

    Society Early Career Conference 2014  7–11 January 2014, Biogeography  Society  Early Career Conference 2014.   The conference is  jointly  supported  by  the  IBS  (

  4. A cultural communities approach to teacher early literacy practices

    E-Print Network [OSTI]

    Garrity, Sarah M.

    2011-01-01

    early childhood programs (revised edition). Washington, DC:in early childhood programs, the new edition “defines moreProgram Curriculum The Creative Curriculum for Preschool, fourth edition (

  5. The Princeton Tritium Observatory for Light, Early Universe,...

    Office of Environmental Management (EM)

    The Princeton Tritium Observatory for Light, Early Universe, Massive Neutrino Yield (PTOLEMY) The Princeton Tritium Observatory for Light, Early Universe, Massive Neutrino Yield...

  6. Falls, Disability and Food Insecurity Present Challenges to Healthy Aging

    E-Print Network [OSTI]

    Wallace, Steven P.; Molina, L. Cricel; Jhawar, Mona

    2007-01-01

    characteristics. Journal of Aging Health. 2001. 13:329-54.for prevention. Age and Aging. 2006:35 Supplement 2:ii37-Present Challenges to Healthy Aging Steven P. Wallace, L.

  7. TEACHING ABOUT THE BIOLOGICAL CLOCK: Age-Related Fertility Decline and Sex Education

    E-Print Network [OSTI]

    Macintosh, Kerry Lynn

    2015-01-01

    to choose motherhood over education or work. 180 Id. at 352.comprehensive sexual health education . ?. ?. ?. ”) (receive HIV/AIDS prevention education once in middle school

  8. Deactivation of Accelerated Engine-Aged and Field-Aged SCR Catalysts...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Field-Aged SCR Catalysts and the Role of the DOC A technique for accelerated aging of SCR system (DOC -> SCR-> DPF) reveals two deactivation mechanisms and replicates...

  9. An Assay to Monitor HIV-1 Protease Activity for the Identification of Novel Inhibitors in T-Cells

    E-Print Network [OSTI]

    Wolkowicz, Roland

    environment for the screening of potential novel PIs in a cell-type that represents the natural milieu of HIV Highly Active Anti-Retroviral Therapy (HAART) have resulted in a drastic reduction in the number of AIDS

  10. The Relationship between Economic Growth and HIV/AIDS in Southern Africa: A Review of the Literature

    E-Print Network [OSTI]

    Costa, Patricia R.

    2006-01-01

    orld DevclopmCllt. 31(1): Barnett, Tony. 2005. "HIV/ AIDS isStudies. 2(3): 219-225. Barnett, Tony and Piers 1'L Blaikie.London: BeUlaven Press. Barnett, Tony and Alan \\Vhiteside.

  11. Examining Public Health System Responses to the Chronic Diseases of HIV/AIDS and Diabetes: Experiences from Mexico and Brazil

    E-Print Network [OSTI]

    Gidi, Virginia Eve

    2010-01-01

    A. Cohn, Health reform in Brazil: lessons to consider. Am JPetersen, M.L. , et al. , Brazil, in The HIV Pandemic: localof the AIDS epidemic in Brazil: principal epidemiological

  12. The Effect of Hepatitis C Virologic Clearance on Cardiovascular Risk Biomarkers in HIV/Hepatitis C Coinfection

    E-Print Network [OSTI]

    Chew, Kara W.

    2012-01-01

    T, Bregenzer A, et al. Hepatitis C virus infections in theLu SN, et al. Chronic hepatitis C virus infection increasesP, Taylor CB, Norris S. Hepatitis C and HIV-1 coinfection.

  13. An Offer You Can't Refuse: Provider-Initiated HIV Testing in Antenatal Clinics in Rural Malawi

    E-Print Network [OSTI]

    Angotti, Nicole; Dionne, Kim Y.; Gaydosh, Lauren

    2008-01-01

    An Offer You Can’t Refuse: Provider-Initiated HIV Testing inWorking Paper Series An Offer You Can’t Refuse: Provider-data from Malawi, we offer an account of the perceptions

  14. Structural and functional investigation of human chemokines and applications of human chemokines in blocking HIV-1 entry 

    E-Print Network [OSTI]

    Jin, Hongjun

    2009-05-15

    , metastasis, and HIV infections. No direct structural information about any chemokine receptor is available, but the structure of chemokines has been well studied. Structural studies of chemokines coupled with cell-biological investigations may lead to a...

  15. A crossfield literature review of the HIV and AIDS impacts on the Ugandan workforce through the HRD lens 

    E-Print Network [OSTI]

    Howard, Debra Mayes

    2005-02-17

    Museveni, editorials, foundation 9 and corporate reports and multi-NPS entities (INGO, NGO, CBO, and FBO) as ?the method of discovery to gain insight and understanding? (Merriam, 1998) into the impacts of HIV and AIDS on the Ugandan workforce and how... HRD impacts can help improve workforce and decrease HIV and AIDS incidence and prevalence. Collection of Data Procedures for synthesizing data are through the analysis of volumes of text data (Bogdan and Biklen, 2003), focusing upon the impacts...

  16. TGF- Sma/Mab Signaling Mutations Uncouple Reproductive Aging from Somatic Aging

    E-Print Network [OSTI]

    Murphy, Coleen

    mutations and treatments that extend C. elegans' reproductive period also regulate longevity, suggesting, with infertility and maternal age-related birth defects arising during the fourth decade of life [1]. While reproductive aging may allow us to address the problems of maternal age-related infertility and birth defects

  17. Making Sustainability Visible: Two Early Childhood Education Centers

    E-Print Network [OSTI]

    Making Sustainability Visible: Two Early Childhood Education Centers Jenny Young, Anna Liu evaluation compares two early childhood education centers built in 2007 in two very different parts of rural-occupancy, sustainability, children INTRODUCTION: COMPARING TWO CENTERS FOR EARLY CHILDHOOD EDUCATION Redwood Early

  18. Sensemaking and knowledge creation in early warning detection

    E-Print Network [OSTI]

    EarlyWarningandEarlyResponse NonGovernmentalOrganiza2on FEWERAfrica,Eurasia,Russia PacificTsunamiWarningSystem Intergovernmental sufficiently in advance for preventive action to be initiated. An early warning system is a network of actors EpidemicandPandemicAlertandResponse GIEWS GlobalInforma2onandEarlyWarningSystem FoodandAgricultureOrganiza2

  19. Reliability and predictive validity of a hepatitis-related symptom inventory in HIV-infected individuals referred for Hepatitis C treatment

    E-Print Network [OSTI]

    2011-01-01

    immunodeficiency virus and hepatitis C virus coinfectedcoinfected with HIV and hepatitis C virus. J Viral Hepattreatment prescription for hepatitis C. Gut 2007, 27. Dell’

  20. Community, Family, and Partner-Related Stigma Experienced by Pregnant and Postpartum Women with HIV in Ho Chi Minh City, Vietnam

    E-Print Network [OSTI]

    Brickley, Deborah Bain; Dung Hanh, Dang; Nguyet, Luu Thi; Mandel, Jeffrey S.; Giang, Le Truong; Sohn, Annette H.

    2009-01-01

    stigma and discrimination in Vietnam. Wash- ington, DC:epidemic among women in Vietnam. BMC Public Health, 8, 37.the context of HIV in Vietnam. Culture, Health & Sexuality,

  1. Lithium evolution in intermediate age and old open clusters: NGC 752 revisited

    E-Print Network [OSTI]

    P. Sestito; S. Randich; R. Pallavicini

    2004-07-15

    We present new high resolution spectroscopic observations of the intermediate age (~2 Gyr) open cluster NGC 752. We investigate the Li vs. Teff distribution and we obtain a new accurate determination of the cluster metallicity. We compare the results for NGC 752 with other intermediate age and old clusters spanning the age range from the Hyades (~0.6 Gyr) to NGC 188 (~6-8 Gyr). We find that NGC 752 has a solar iron content ([Fe/H]=+0.01+/-0.04), at variance with early reports of sub-solar metallicity. We find that NGC 752 is only slightly more Li depleted than the younger Hyades and has a Li pattern almost identical to that observed in the ~2 Gyr old IC 4651 and NGC 3680. As for the latter clusters, we find that NGC 752 is characterized by a tight Li vs. Teff distribution for solar-type stars, with no evidence for a Li spread as large as the one observed in the solar age solar metallicity M 67. We discuss these results in the framework of mixing mechanisms and Li depletion on the main sequence (MS). We conclude that the development of a large scatter in Li abundances in old open clusters might be an exception rather than the rule (additional observations of old clusters are required), and that metallicity variations of the order of ~0.2 dex do not affect Li depletion after the age of the Hyades.

  2. Utah Commission on Aging December Meeting Minutes

    E-Print Network [OSTI]

    Tipple, Brett

    ­ Chair UT Area Agencies on Aging Excused Gary Kelso Long-Term Care William (Bill) Knowles UT Guests X Marion Davis (on behalf of Karla Aguirre) Dept. of Workforce Services X Cole Hansen Gov

  3. Aging of polymeric composites : a literature review

    E-Print Network [OSTI]

    Treviño-Garrido, Margie N

    2013-01-01

    Due to their increased use in today's society, an extensive survey was undertaken in this report to condense what's been, thus far, discovered as to the effects of aging on polymeric composites. Special emphasis was placed ...

  4. Utah Commission on Aging June 3, 2008

    E-Print Network [OSTI]

    Tipple, Brett

    Thatcher for Kristin Cox Workforce Services Shauna O'Neil Salt Lake County Aging Services Lynne Shaffer for Deborah Bayle United Way Archie Archuleta Ethnic Minorities Alan Ormsby for LM Church Utah Department

  5. Automatic Speech Recognition for ageing voices 

    E-Print Network [OSTI]

    Vipperla, Ravichander

    2011-11-24

    With ageing, human voices undergo several changes which are typically characterised by increased hoarseness, breathiness, changes in articulatory patterns and slower speaking rate. The focus of this thesis is to understand ...

  6. Edublogging : instruction for the digital age learner

    E-Print Network [OSTI]

    Felix, Jeffrey P.

    2007-01-01

    P. (2002). Blogs: A disruptive technology coming of age?I'm using the web, blogs, and other technology to supplementTechnology Access 249 xiii The Differences between Forums and Blogs.

  7. Education: Early Childhood Studies (ECS) Page 111Sonoma State University 2014-2015 Catalog EDUCATION: EARLY CHILDHOOD STUDIES

    E-Print Network [OSTI]

    Ravikumar, B.

    Education: Early Childhood Studies (ECS) Page 111Sonoma State University 2014-2015 Catalog EDUCATION: EARLY CHILDHOOD STUDIES (ECS) DEPARTMENT OFFICE Stevenson 1078 (707) 664 3238 fax: (707) 664 2483 a major in Early Childhood Studies, a minor in Early Childhood Studies and a Master of Arts in education

  8. Neural Networks Early Neural Network Modeling

    E-Print Network [OSTI]

    Yuste, Rafael

    Appendix E Neural Networks Early Neural Network Modeling Neurons Are Computational Devices A Neuron? This is the central question moti- vating the study of neural networks. In this appendix we provide a brief historical review of the field, intro- duce some key concepts, and discuss two influential models of neural networks

  9. Hardware Supported Flexible Monitoring: Early Results

    E-Print Network [OSTI]

    Zhai, Antonia

    Hardware Supported Flexible Monitoring: Early Results Antonia Zhai, Guojin He, and Mats P. Monitoring of software's execution is crucial in numerous software development tasks. Current monitoring software must be studied in its pro- duction environment. To address this fundamental software engineering

  10. ...offers early cost-effectiveness check

    E-Print Network [OSTI]

    Oakley, Jeremy

    that an innovation is a `must' ­ offering lower costs for enhanced health outcomes. Or it might turn outMATCH Tool ...offers early cost- effectiveness check on innovations ® Medical Device Evaluation and costs persuade the NHS to buy the innovation? In just three hours, the company was able to check out its

  11. Alcohol and Historiography in Early China

    E-Print Network [OSTI]

    Sterckx, Roel

    2015-06-16

    , it was also a corner stone in sacrificial ritual and therefore an important measure to please the spirit world. In assessing the past, early Chinese writers often judged rulers and their regimes based on the way they handled alcohol and ritualized drinking...

  12. Weather and Forecasting EARLY ONLINE RELEASE

    E-Print Network [OSTI]

    Weather and Forecasting EARLY ONLINE RELEASE This is a preliminary PDF of the author, Guangzhou 510301, China9 2. State Key Laboratory of Severe Weather, Chinese Academy of Meteorological10, China20 21 22 23 24 Submitted to Weather and Forecasting25 2014. 12. 2826 27 Corresponding author: Dr

  13. Monthly Weather Review EARLY ONLINE RELEASE

    E-Print Network [OSTI]

    Collett Jr., Jeffrey L.

    Monthly Weather Review EARLY ONLINE RELEASE This is a preliminary PDF of the author into numerical weather4 prediction models can improve precipitation forecasts and extend prediction capabilities5 that assimilates precipitation-affected microwave radiances into the7 Weather Research and Forecasting (WRF) model

  14. Weather and Forecasting EARLY ONLINE RELEASE

    E-Print Network [OSTI]

    Johnson, Richard H.

    Weather and Forecasting EARLY ONLINE RELEASE This is a preliminary PDF of the author Fort Collins, Colorado7 October 20128 (submitted to Weather and Forecasting)9 1 Corresponding author address: Rebecca D. Adams-Selin, HQ Air Force Weather Agency 16th Weather Squadron, 101 Nelson Dr., Offutt

  15. Monthly Weather Review EARLY ONLINE RELEASE

    E-Print Network [OSTI]

    Johnson, Richard H.

    Monthly Weather Review EARLY ONLINE RELEASE This is a preliminary PDF of the author, Colorado5 December 20126 (submitted to Monthly Weather Review)7 1 Corresponding author address: Rebecca D. Adams-Selin, HQ Air Force Weather Agency 16th Weather Squadron, 101 Nelson Dr., Offutt AFB, NE, 68113

  16. Monthly Weather Review EARLY ONLINE RELEASE

    E-Print Network [OSTI]

    Johnson, Richard H.

    Monthly Weather Review EARLY ONLINE RELEASE This is a preliminary PDF of the author and have been linked to severe weather and flooding in northern Mexico and the southwest United States 2001; Douglas and Leal 2003; Gochis et al. 2004; Higgins et al. 2004) and severe weather outbreaks

  17. Monthly Weather Review EARLY ONLINE RELEASE

    E-Print Network [OSTI]

    Heinselman, Pamela L.

    Monthly Weather Review EARLY ONLINE RELEASE This is a preliminary PDF of the author its first bow echo was captured by9 the National Weather Radar Testbed Phased Array Radar (NWRT PAR weather events, such as quasi-linear convective systems (QLCSs). Trapp et al.29 (2005) found that 18

  18. Neutron Capture Nucleosynthesis in Early Galactic Environments #

    E-Print Network [OSTI]

    Cowan, John

    Neutron Capture Nucleosynthesis in Early Galactic Environments # James W. Truran 1 , John J. Cowan we can extract useful clues to and constraints upon the star formation and nucleosynthesis history that provide the site for s­process nucleosynthesis during the AGB phase of their evolution. We review recent

  19. Two-step build-up of a thermoreversible polymer network: From early local to late collective dynamics

    E-Print Network [OSTI]

    H. Souguir; O. Ronsin; C. Caroli; T. Baumberger

    2015-03-05

    We probe the mechanisms at work in the build-up of thermoreversible gel networks, with the help of hybrid gelatin gels containing a controlled density of irreversible, covalent crosslinks (CL), which we quench below the physical gelation temperature. The detailed analysis of the dependence on covalent crosslink density of both the shear modulus and optical activity evolutions with time after quench enables us to identify two stages of the physical gelation process, separated by a temperature dependent crossover modulus: (i) an early nucleation regime during which rearrangements of the triple-helix CL play a negligible role, (ii) a late, logarithmic aging one, which is preserved, though slowed down, in the presence of irreversible CL. We show that aging is fully controlled by rearrangements and discuss the implication of our results in terms of the switch from an early, local dynamics to a late, cooperative long-range one.

  20. Bulk Flows and End of the Dark Ages with the SKA

    E-Print Network [OSTI]

    Maio, Umberto; Koopmans, Leon V E

    2015-01-01

    The early Universe is a precious probe of the birth of primordial objects, first star formation events and consequent production of photons and heavy elements. Higher-order corrections to the cosmological linear perturbation theory predicts the formation of coherent supersonic gaseous streaming motions at decoupling time. These bulk flows impact the gas cooling process and determine a cascade effect on the whole baryon evolution. By analytical estimates and N-body hydrodynamical chemistry numerical simulations including atomic and molecular evolution, gas cooling, star formation, feedback effects and metal spreading for individual species from different stellar populations according to the proper yields and lifetimes, we discuss the role of these primordial bulk flows at the end of the dark ages and their detectable impacts during the first Gyr in view of the upcoming SKA mission. Early bulk flows can inhibit molecular gas cooling capabilities, suppressing star formation, metal spreading and the abundance of ...

  1. A review of "Conscience on Stage: The Comedia as Casuistry in Early Modern Spain" by Hillaire Kallendorf 

    E-Print Network [OSTI]

    Wright, Elizabeth

    2009-01-01

    historians? (20). Hilaire Kallendorf. Conscience on Stage: The Comedia as Casuistry in Early Modern Spain. Toronto: University of Toronto Press, 2007. x + 299 pp. $65. Review by elizabeth r. wright, university of georgia. Spain?s national theater... miniscule proportion of plays have attracted careful and sustained scholarly scrutiny or are performed regularly in repertories. This book reports on one scholar?s project to widen the lens through which we view Spain?s ?Golden Age? theater...

  2. Forever Young: Aging Control In DTNs

    E-Print Network [OSTI]

    Altman, Eitan; Menasche, Daniel Sadoc; Xu, Yuedong

    2010-01-01

    The demand for Internet services that require frequent updates through small messages, also known as microblogging, has tremendously grown in the past few years. Although the use of such applications by domestic users is usually free, their access from mobile devices is subject to fees and consumes energy from limited batteries. If a user activates his mobile device and is in range of a service provider, a content update is received at the expense of monetary and energy costs. Thus, users face a tradeoff between such costs and their messages aging. The goal of this paper is to show how to cope with such a tradeoff, by devising \\emph{aging control policies}. An aging control policy consists of deciding, based on the current utility of the last message received, whether to activate the mobile device, and if so, which technology to use (WiFi or 3G). We present a model that yields the optimal aging control policy. Our model is based on a Markov Decision Process in which states correspond to message ages. Using ou...

  3. Restructuring and aging in a capillary suspension

    E-Print Network [OSTI]

    Erin Koos; Wolfgang Kannowade; Norbert Willenbacher

    2014-10-16

    The rheological properties of capillary suspensions, suspensions with small amounts of an added immiscible fluid, are dramatically altered with the addition of the secondary fluid. We investigate a capillary suspension to determine how the network ages and restructures at rest and under applied external shear deformation. The present work uses calcium carbonate suspended in silicone oil (11 % solids) with added water as a model system. Aging of capillary suspensions and their response to applied oscillatory shear is distinctly different from particulate gels dominated by the van der Waals forces. The suspensions dominated by the capillary force are very sensitive to oscillatory flow, with the linear viscoelastic regime ending at a deformation of only 0.1 % and demonstrating power-law aging behavior. This aging persists for long times at low deformations or for shorter times with a sudden decrease in the strength at higher deformations. This aging behavior suggests that the network is able to rearrange and even rupture. This same sensitivity is not demonstrated in shear flow where very high shear rates are required to rupture the agglomerates returning the apparent viscosity of capillary suspensions to the same viscosity as for the pure vdW suspension. A transitional region is also present at intermediate water contents wherein the material response depends very strongly on the type, strength, and duration of the external forcing.

  4. Insights into the respiratory tract microbiota of patients with cystic fibrosis during early Pseudomonas aeruginosa colonization

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Keravec, Marlène; Mounier, Jérôme; Prestat, Emmanuel; Vallet, Sophie; Jansson, Janet K.; Burgaud, Gaëtan; Rosec, Sylvain; Gouriou, Stéphanie; Rault, Gilles; Coton, Emmanuel; et al

    2015-08-09

    Pseudomonas aeruginosa plays a major role in cystic fibrosis (CF) progression. Therefore, it is important to understand the initial steps of P. aeruginosa infection. The structure and dynamics of CF respiratory tract microbial communities during the early stages of P. aeruginosa colonization were characterized by pyrosequencing and cloning-sequencing. The respiratory microbiota showed high diversity, related to the young age of the CF cohort (mean age 10 years). Wide inter- and intra-individual variations were revealed. A common core microbiota of 5 phyla and 13 predominant genera was found, the majority of which were obligate anaerobes. A few genera were significantly moremore »prevalent in patients never infected by P. aeruginosa. Persistence of an anaerobic core microbiota regardless of P. aeruginosa status suggests a major role of certain anaerobes in the pathophysiology of lung infections in CF. Some genera may be potential biomarkers of pulmonary infection state.« less

  5. Call for Applications: Predoctoral Training Affiliates The Specialized Training Program in the Demography and Economics of Aging at NORC at University of Chicago,

    E-Print Network [OSTI]

    He, Chuan

    and economics of aging through the development of basic and applied research and policy- making and analysis in the development of research ideas and areas of specialty; 2) training and support in manuscript development Demography Workshop and Post-Mortem Seminar. Benefits Affiliates benefit from 1) early guidance

  6. ABUNDANCE, AGE, AND FECUNDITY OF SHAD, YORK RIVER,VA., 1953-59 By Paul R. Nichols 1 and WillIam H. Massmann 2

    E-Print Network [OSTI]

    ' the York River system. During the spring spawning run of 1959, personnel of the Bureau of Commercial to the st.ream of origin to spawn. Adult shad enter the York River as early as .January, and the run usuullyABUNDANCE, AGE, AND FECUNDITY OF SHAD, YORK RIVER,VA., 1953-59 By Paul R. Nichols 1 and WillIam H

  7. Feeding the periphery : modeling early Bronze Age economies and the cultural landscape of the Faynan District, Southern Jordan

    E-Print Network [OSTI]

    Muniz, Adolfo A.

    2007-01-01

    associated with production and consumption revolving aroundseen from the production and consumption of animal remainsthese objectives, production and consumption of animals and

  8. Feeding the periphery : modeling early Bronze Age economies and the cultural landscape of the Faynan District, Southern Jordan

    E-Print Network [OSTI]

    Muniz, Adolfo A.

    2007-01-01

    centers. Increase in demand for copper resulted inexchange driven by a demand for copper. Undoubtedly, the newregion where copper was in large demand by the regional

  9. Secondary state formation during the early iron age on the island of Sri Lanka : the evolution of a periphery

    E-Print Network [OSTI]

    Karunaratne, Priyantha Padmalal

    2010-01-01

    Chicago, Illinois, in (52) Symposium- Beyond basic formationIllinois. March 1999. xx ABSTRACT OF THE DISSERTATION Secondary State Formation

  10. Early-age concrete temperature and moisture relative to curing effectiveness and projected effects on selected aspects of slab behavior 

    E-Print Network [OSTI]

    Ye, Dan

    2009-05-15

    of TMAC2 program. The concrete pavement was cast at the FAA National Airport Pavement Test Facility (NAPTF) near Atlantic City, New Jersey. In this study, the concrete set maturity was 6 determined and the relationship between shrinkage................................................................................... 144 Fig. V-10. Vibrating Wire Gage EM-5........................................................................ 144 Fig. V-11. Free Shrinkage Test Setup.......................................................................... 145 Fig. V-12...

  11. Feeding the periphery : modeling early Bronze Age economies and the cultural landscape of the Faynan District, Southern Jordan

    E-Print Network [OSTI]

    Muniz, Adolfo A.

    2007-01-01

    to the production of metal such as casting and ingot moulds,consisting of metal prills, ore, slag, and casting mouldmultiple pin casting moulds, 2. re-cycle metal remains from

  12. Feeding the periphery : modeling early Bronze Age economies and the cultural landscape of the Faynan District, Southern Jordan

    E-Print Network [OSTI]

    Muniz, Adolfo A.

    2007-01-01

    2000 Archaeology and desertification in Wadi Faynan. LevantDeserts: Constrasting Desertification Histories on Rome's2000 Archaeology and Desertification in the Wadi Faynan: The

  13. Health, Medicine and Aging Concentration Concentrations in Sociology

    E-Print Network [OSTI]

    Turc, Catalin

    Sociology Health, Medicine and Aging Concentration Concentrations in Sociology Students majoring. The 4 concentrations are: · Crime, Law and Justice · Health, Medicine and Aging · Gender, Work and Family · Social Inequality Health, Medicine and Aging Concentration Undergraduate students majoring

  14. INCREASED STRENGTHENING OF AUSTENITIC ALLOYS THROUGH DUAL AGING

    E-Print Network [OSTI]

    Ma, Annie

    2011-01-01

    d o - - -700°C after first aging at 745°C /2 hr tween) (nobJ,J". _.J__ __JI (TOTAL) AGING TIME (hr) XBL Figure 22 aALLOYS THROUGH DUAL AGING Annie Ma Inorganic Materials

  15. Memory for sequences of events impaired in typical aging.

    E-Print Network [OSTI]

    Allen, TA; Morris, AM; Stark, SM; Fortin, NJ; Stark, CE

    2015-01-01

    340. Salthouse TA. 2000. Aging and measures of processingSpecific- and partial- source memory: effects of aging.Psychol Aging 19: 689 –694. Small SA, Tsai WY, DeLaPaz R,

  16. Understanding the Emotions of Others: Loss or Gain in Aging?

    E-Print Network [OSTI]

    Sze, Jocelyn Andrea

    2010-01-01

    theory. Psychology and Aging, 7(3), 331-8. Carstensen, L.2007). The Handbook of Aging and Cognition: Third Edition (The Posterior-Anterior Shift in Aging. Cereb. Cortex, 18(5),

  17. Acceptability of formula-feeding to prevent HIV postnatal transmission, Abidjan, Cte d'Ivoire, 01-04: ANRS 1201/1202 Ditrame-Plus Study

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Acceptability of formula-feeding to prevent HIV postnatal transmission, Abidjan, Côte d: Acceptability of formula feeding in Africa inserm-00177042,version1-13Jun2008 #12;3 Abstract Objective: To describe the maternal acceptability of formula-feeding proposed to reduce postnatal HIV transmission

  18. Investigation of chemical and radiological aging of simulated Hanford ferrocyanide wastes

    SciTech Connect (OSTI)

    Lilga, M.A.; Hallen, R.T.; Lumetta, M.R.; Hogan, M.O. [Pacific Northwest Lab., Richland, WA (United States)] [and others

    1996-10-01

    Radioactive waste resulting from the production of defense nuclear materials has been stored in underground storage tanks at the Hanford Site since the early 1940s. Radiocesium scavenging campaigns conducted in the 1950s, involving carrier-precipitation of cesium nickel ferrocyanide by addition of sodium ferrocyanide and nickel sulfate, added large quantities of ferrocyanide (about 145 metric tons) to the waste. Subsequent operations added other highly basic wastes to the ferrocyanide sludge. This paper reports studies into how the ferrocyanide sludge may have chemically and radiolytically changed, or aged, after being in contact for over 40 years with caustic wastes in a radiation field. Aging studies were conducted using simulated Hanford ferrocyanide wastes and the effects of temperature, gamma dose rate, and pH on solubility and hydrolysis were investigated. The results of these studies will be reported in this presentation.

  19. Early Events in Ionic Liquid Radiation Chemistry

    SciTech Connect (OSTI)

    Wishart, J.F.; Cook, A.; Rimmer, R.D.; Gohdo, M.

    2010-09-14

    Ionic liquids are interesting and useful materials whose solvation time scales are up to thousands of times longer than in conventional solvents. The extended lifetimes of pre-solvated electrons and other energetic species in ionic liquids has profound consequences for the radiolytic product distributions and reactivity patterns. We use a newly developed, multiplexed variation of pulse-probe spectroscopy to measure the kinetics of the early dynamical and reactive events in ionic liquids.

  20. Early Life Crises of Habitable Planets

    ScienceCinema (OSTI)

    Pierrehumbert, Raymond [University of Chicago, Chicago, Illinois, United States

    2009-09-01

    There are a number of crises that a potentially habitable planet must avoid or surmount if its potential is to be realized. These include the runaway greenhouse, loss of atmosphere by chemical or physical processes, and long-lasting global glaciation. In this lecture I will present research on the climate dynamics governing such processes, with particular emphasis on the lessons to be learned from the cases of Early Mars and the Neoproterozoic Snowball Earth.

  1. STARTech Early Ventures | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onRAPID/Geothermal/Exploration/ColoradoRemsenburg-Speonk, NewMichigan:Roxbury,RushS.KSPARQL Query FormSTARTech Early

  2. Stress Relaxation in Aging Soft Colloidal Glasses

    E-Print Network [OSTI]

    Ranjini Bandyopadhyay; P. Harsha Mohan; Yogesh M. Joshi

    2010-03-25

    We investigate the stress relaxation behavior on the application of step strains to aging aqueous suspensions of the synthetic clay Laponite. The stress exhibits a two-step decay, from which the slow relaxation modes are extracted as functions of the sample ages and applied step strain deformations. Interestingly, the slow time scales that we estimate show a dramatic enhancement with increasing strain amplitudes. We argue that the system ends up exploring the deeper sections of its energy landscape following the application of the step strain.

  3. Aging assessment for active fire protection systems

    SciTech Connect (OSTI)

    Ross, S.B. [Science and Engineering Associates, Inc. (United States); Nowlen, S.P.; Tanaka, T. [Sandia National Labs., Albuquerque, NM (United States)

    1995-06-01

    This study assessed the impact of aging on the performance and reliability of active fire protection systems including both fixed fire suppression and fixed fire detection systems. The experience base shows that most nuclear power plants have an aggressive maintenance and testing program and are finding degraded fire protection system components before a failure occurs. Also, from the data reviewed it is clear that the risk impact of fire protection system aging is low. However, it is assumed that a more aggressive maintenance and testing program involving preventive diagnostics may reduce the risk impact even further.

  4. Tritium Aging Effects in Palladium on Kieselguhr

    SciTech Connect (OSTI)

    Shanahan, K.L.; Holder, J.S.; Wermer, J.R.

    1998-10-01

    50 weight % Pd on kieselguhr (Pd/k) is used in hydrogen isotope separation processes at the Savannah River Site. Long term aging studies on this material were undertaken in June, 1992. P-c-T data showing the aging effect of tritium loading for long periods will be presented and discussed covering from June, 1992 to March, 1997. Lowering of plateau pressures and increasing indications of in homogeneities have been observed in both tritium and deuterium absorption isotherms at 0 C, and desorption isotherms at 80 and 120 C.

  5. Mechanical Testing of TR-55 Rubber Thermally Aged Under Tensile...

    Office of Scientific and Technical Information (OSTI)

    Mechanical Testing of TR-55 Rubber Thermally Aged Under Tensile Strain Citation Details In-Document Search Title: Mechanical Testing of TR-55 Rubber Thermally Aged Under Tensile...

  6. The Development of Rapid Aging and Poisoning Protocols for Diesel...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    The Development of Rapid Aging and Poisoning Protocols for Diesel Aftertreatment Devices The Development of Rapid Aging and Poisoning Protocols for Diesel Aftertreatment Devices...

  7. Rapid Aging Protocols for Diesel Aftertreatment Devices: NOx...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Aging Protocols for Diesel Aftertreatment Devices: NOx Abatement Catalysts Rapid Aging Protocols for Diesel Aftertreatment Devices: NOx Abatement Catalysts Poster presentation at...

  8. Diagnostic and Prognostic Analysis of Battery Performance & Aging...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Prognostic Analysis of Battery Performance & Aging based on Kinetic and Thermodynamic Principles Diagnostic and Prognostic Analysis of Battery Performance & Aging based on...

  9. An Accelerated Aging Method for Diesel Exhaust Aftertreatment...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    An Accelerated Aging Method for Diesel Exhaust Aftertreatment Systems An Accelerated Aging Method for Diesel Exhaust Aftertreatment Systems Poster presented at the 16th Directions...

  10. Effect of non-ageing and ageing ceria nanoparticles suspensions on fresh water micro-algae

    E-Print Network [OSTI]

    Boyer, Edmond

    Effect of non-ageing and ageing ceria nanoparticles suspensions on fresh water micro-algae Manier nanoparticle (nCeO2) suspensions, towards freshwater micro-algae assessing the effect nCeO2 suspensions microscopy (TEM). In addition, the interaction between NPs and algae were investigated using flow

  11. Early Users to Test New Burst Buffer on Cori

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Early Users to Test New Burst Buffer on Cori Early Users to Test New Burst Buffer on Cori Designed to Accelerate IO Performance October 5, 2015 | Tags: Burst Buffer, Cori...

  12. The Construction of Early Modernity in Spanish Film 

    E-Print Network [OSTI]

    Zarate Casanova, Miguel Angel

    2011-10-21

    The presence of early modern Spanish history in Spanish film has received only limited scholarly attention. The entire group of Spanish films dealing with the Spanish early modern era has never been placed under study by any overarching research...

  13. Increasing Creel Interview Efficiency Through Early Survey Termination

    E-Print Network [OSTI]

    Increasing Creel Interview Efficiency Through Early Survey Termination HAL R. OSBURN and MIKE G were terminated early when no angler interviews were con ducted by a specified time. Using this method, terminating

  14. Opportunities for the Early Production of Fischer-Tropsch (F...

    Office of Environmental Management (EM)

    Opportunities for the Early Production of Fischer-Tropsch (F-T) Fuels in the U.S. -- An Overview Opportunities for the Early Production of Fischer-Tropsch (F-T) Fuels in the U.S....

  15. A Model of Spacetime Emergence in the Early Universe

    E-Print Network [OSTI]

    Tysanner, Martin William

    2012-01-01

    EMERGENCE IN THE EARLY UNIVERSE A dissertation submitted inEmergence in the Early Universe by Martin W. Tysanner Thisearly evolution of a universe. Two di?erent considerations

  16. Narayanaswamy's 1971 aging theory and material time

    E-Print Network [OSTI]

    Jeppe C. Dyre

    2015-08-23

    The Bochkov-Kuzovlev nonlinear fluctuation-dissipation theorem is used to derive Narayanaswamy's phenomenological theory of physical aging, in which this highly nonlinear phenomenon is described by a linear material-time convolution integral. A characteristic property of the Narayanaswamy aging description is material-time translational invariance, and this is here taken as a basic assumption of the derivation. It is shown that only one possible definition of the material time obeys this invariance, namely the square of the distance travelled from a configuration of the system far back in time. The paper concludes with suggestions for computer simulations that test for consequences of material-time translational invariance. One of these is a "unique-triangles property" according to which any three points on the system's path form a triangle such that two side lengths determine the third; this is analogous to the well-known triangular relation for time-autocorrelation functions of aging spin glasses [L. F. Cugliandolo and J. Kurchan, J. Phys. A: Math. Gen. 27, 5749 (1994)]. The unique-triangles property implies a simple geometric interpretation of out-of-equilibrium time-autocorrelation functions, which extends to aging a previously proposed framework for such functions in equilibrium [J. C. Dyre, cond-mat/9712222].

  17. Life history, longevity and aging Population ecology

    E-Print Network [OSTI]

    Wilkinson, Gerald S.

    = intrinsic rate of population growth dN/dt = (b-d)N = rN "r-selected" #12;Logistic population growth Addition of a density dependent term results in logistic growth K = carrying capacity dN/dt = rN (K-N)/K "K to allocation of resources between maintenance and reproduction #12;Reproductive value · Age

  18. The Mobile Web Comes of Age

    E-Print Network [OSTI]

    Chen, Yuanzhu Peter

    The Mobile Web Comes of Age Steven J. Vaughan-Nichols T he mobile Web has changed dramatically can do on the Web, said Stephen O'Grady, cofounder of and analyst with Red- Monk, a market research, such as phones, now have larger screens with better resolution, making Web browsing more worthwhile, noted

  19. Eucalyptus fuelwood growth rate improves with age

    E-Print Network [OSTI]

    Eucalyptus fuelwood growth rate improves with age Dean R. Donaldson 0 Richard B. Standiford I n The two species of Eucalyptus were the fastest growing of the five tree spe- cies evaluated at Grant Street (table 1). Manna gum, Eucalyptus viminalis, al- though about a year younger, is signifi- cantly

  20. Utah Commission on Aging April 1, 2008

    E-Print Network [OSTI]

    Tipple, Brett

    Lake County Aging Services Lynne Shaffer for Deborah Bayle United Way Archie Archuleta Ethnic Minorities William Cox Utah Association of Counties Alan Ormsby for LM Church Utah Department of Human or sold to other providers for underserved areas. The Medicaid Task Force was not renewed. Alan Ormsby

  1. ANNUAL CONFERENCE ON SUCCESSFUL AGING FINDING BALANCE

    E-Print Network [OSTI]

    3RD ANNUAL CONFERENCE ON SUCCESSFUL AGING FINDING BALANCE: ENHANCING PHYSICAL, EMOTIONAL, and how to improve them. Finding Balance Supports Our Well-Being. Dr. Glisky will talk about how balance in humans; Evolutionary medicine. Balance Exercises and Fitness to Prevent Injuries and Cognitive Decline

  2. AGE -A HEA Cancer FoRs

    E-Print Network [OSTI]

    Balasuriya, Sanjeeva

    CANCER CANCER R REVIEW D DR ADAM B FoRs RESEARCH DOCUMENT BUTLER, RE H COVERA T ESEARCH P AGE;Cancer FoRs 5 June 2013 Page 2 BACKGROUND This document was created for the Health and Medical Research Strategic Review and attempts to outline the coverage of cancer research throughout the university

  3. Discouraging Software Piracy Using Software Aging

    E-Print Network [OSTI]

    Discouraging Software Piracy Using Software Aging Markus Jakobsson Michael Reiter Abstract Most people consider frequent software updates a nuisance. However, we show how this common phenomenon can be turned into a feature that protects against software piracy. We define a protocol for "drop-in" upgrades

  4. Stone Age Distributed Computing (Extended Abstract)

    E-Print Network [OSTI]

    Stone Age Distributed Computing (Extended Abstract) Yuval Emek Distributed Computing Group ETH Zurich, Switzerland yemek@ethz.ch Roger Wattenhofer Distributed Computing Group ETH Zurich, Switzerland and cellular automata is suitable for applying the distributed computing lens to the study of networks of sub

  5. STRAIN AGING OF AUSTENITIC HADFIELD MANGANESE STEEL

    E-Print Network [OSTI]

    Grujicic, Mica

    STRAIN AGING OF AUSTENITIC HADFIELD MANGANESE STEEL W. S. OWEN1 { and M. GRUJICIC2 1 Department®eld steel is discussed in terms of the interstitial octahedron, local-order model, which de®nes order on the metal sublattice are frozen on sites determined either by the high-temperature equilibrium anneal

  6. Deactivation of Accelerated Engine-Aged and Field-Aged SCR Catalysts and the Role of the DOC

    Broader source: Energy.gov [DOE]

    A technique for accelerated aging of SCR system (DOC -> SCR-> DPF) reveals two deactivation mechanisms and replicates field-aged effects

  7. Optimal Seismic Network Density for Earthquake Early Warning: A Case

    E-Print Network [OSTI]

    Allen, Richard M.

    Optimal Seismic Network Density for Earthquake Early Warning: A Case Study from California by H and the public actively use early warning information is a crucial factor in early warning system design (Aktas detection and alert-filtering algorithms; and (d) well-developed seismic networks with improved station

  8. Roadmap: Early Childhood Education Technology Associate of Applied Science

    E-Print Network [OSTI]

    Sheridan, Scott

    Roadmap: Early Childhood Education Technology ­ Associate of Applied Science [RE-AAS-ECET] Regional Enrollment based on placement test; students preparing for the BSE in Early Childhood Education must earn 14001; students preparing for the BSE in Early Childhood Education must earn a minimum C grade 0

  9. Child Care Provider Training Helping Early Childhood Educators

    E-Print Network [OSTI]

    Child Care Provider Training Helping Early Childhood Educators Provide Quality Care for Today that were not conducted by Extension. In addition to the face-to-face conferences, early childhood educators at these conferences on a variety of topics related to child care. Online Training. Extension's Early Childhood

  10. School of Continuing Education Center for Early Childhood

    E-Print Network [OSTI]

    Saldin, Dilano

    School of Continuing Education Center for Early Childhood Professional Development & Leadership www.sce-earlychildhood.uwm.edu Program Support Aide The Center for Early Childhood Professional Development & Leadership at the School service and organizational skills. This Center serves professionals in the early care and education field

  11. EARLY CHILDHOOD CARE AND EDUCATION: ECONOMIC IMPACTS IN DANE COUNTY

    E-Print Network [OSTI]

    Radeloff, Volker C.

    1 EARLY CHILDHOOD CARE AND EDUCATION: ECONOMIC IMPACTS IN DANE COUNTY Prepared by: Gail Kiles on early childhood care and education (ECE) as a social welfare or human capital tool. While these points local sectors. These numbers give concrete support to early childhood and education's economic

  12. MAJOR: HUMAN DEVELOPMENT & FAMILY STUDIES (HDFS) EMPHASIS: EARLY CHILDHOOD EDCUATION

    E-Print Network [OSTI]

    Tipple, Brett

    , SU FCS 2400 Family Relations Across the Life Course (BF) 3 3. EARLY CHILDHOOD EDUCATION CORE (42 with their advisor on a regular basis. Updated 05/15/2013 The Early Childhood Education (ECE) emphasis providesMAJOR: HUMAN DEVELOPMENT & FAMILY STUDIES (HDFS) EMPHASIS: EARLY CHILDHOOD EDCUATION Minimum HDFS

  13. Master of Arts in Education Concentration: Early Childhood Education

    E-Print Network [OSTI]

    Master of Arts in Education Concentration: Early Childhood Education Program of Study (33 credits with EDEC 960 To add certification in Early Childhood Education, the candidate must submit a passing score the Young Child (3) Prerequisites: EDEC 640, 641, 642, 746 Must be the last course in the Early Childhood

  14. Factors influencing digital technology use in early childhood education

    E-Print Network [OSTI]

    Shahriar, Selim

    Factors influencing digital technology use in early childhood education Courtney K. Blackwell extrinsic and intrinsic factors that influence early childhood educators' digital technology use. Survey data from 1234 early childhood educators indicate that attitudes toward the value of technology to aid

  15. Division of Education Early Childhood Special Education Proposal

    E-Print Network [OSTI]

    Gering, Jon C.

    SB #3704 Division of Education Early Childhood Special Education Proposal Submitted By Program that includes an Early Childhood Special Education Certification to be offered within the Division for quality teacher training programs in Early Childhood Special Education (ECSE). A severe shortage

  16. Communication and Early Childhood Research and Practice Center

    E-Print Network [OSTI]

    McQuade, D. Tyler

    Communication and Early Childhood Research and Practice Center at Florida State University DEC intervention/education for young children with special needs and their families. The Communication and Early to the field of early intervention/ education for young children with disabilities, communication disorders

  17. Brain Mechanisms in Early Language Acquisition Patricia K. Kuhl1,*

    E-Print Network [OSTI]

    attest, infants' neural commitment to the elementary units of language begins early, and the review showNeuron Review Brain Mechanisms in Early Language Acquisition Patricia K. Kuhl1,* 1Institute of the phonetic units of language requires learning in a social context. Neuroscience on early language learning

  18. Ages of globular clusters: breaking the age-distance degeneracy with the luminosity function

    E-Print Network [OSTI]

    Paolo Padoan; Raul Jimenez

    1996-03-14

    We extend our previous method to determine globular cluster ages using the luminosity function (Jimenez \\& Padoan 1996). We show that the luminosity function depends on both age and distance modulus and that it is possible to distinguish between the two. This method provides at the same time independent determinations of distance and age of a GC by simply counting the number of stars found inside specified luminosity bins. The main uncertainties in other traditional methods for determining GCs ages are absent (e.g. mixing length, color-$T_{\\rm eff}$ calibration, morphology of the color-magnitude diagram ). The distance modulus is the biggest uncertainty in determining the age of GCs. Here we show that the age can be determined with small uncertainty for any value of distance modulus using the LF and that the LF allows a determination of the distance modulus itself. This is explained by the fact that the luminosity function is affected by a change in distance-modulus in a way that is different from its time evolution. If GC stellar counts with statistical errors not larger than $3\\%$ are available, the age can be determined with an uncertainty of about 0.4 Gyr (independent of distance modulus, mixing length and color calibration) and the distance modulus with an uncertainty of about 0.04 mag.

  19. Stabilizing Exposure of Conserved Epitopes by Structure Guided Insertion of Disulfide Bond in HIV-1 Envelope Glycoprotein

    E-Print Network [OSTI]

    Kassa, Aemro; Dey, Antu K.; Sarkar, Pampi; Labranche, Celia; Go, Eden P.; Clarck, Danile F.; Sun, Yide; Nandi, Avishek; Hartog, Karin; Desaire, Heather; Montefiori, David; Carfri, Andrea; Srivastava, Indresh K.; Barnett, Susan W.

    2013-10-13

    , and reproduction in any medium, provided the original author and source are credited. Funding: This study was supported by the NIAID-NIH HIV Vaccine Research and Design (HIVRAD) grant # 5P01 AI066287. The funders had no role in study design, data collection...-mediated neutralization. Recent high-resolution gp120 structures [5,6] have revealed the complete structure of the inner domain of HIV-1 gp120 that was missing from previous studies [7–10]. These structures showed that the inner domain of gp120 in CD4-bound state...

  20. Quantum Statistical Processes in the Early Universe

    E-Print Network [OSTI]

    B. L. Hu

    1993-02-22

    We show how the concept of quantum open system and the methods in non-equilibrium statistical mechanics can be usefully applied to studies of quantum statistical processes in the early universe. We first sketch how noise, fluctuation, dissipation and decoherence processes arise in a wide range of cosmological problems. We then focus on the origin and nature of noise in quantum fields and spacetime dynamics. We introduce the concept of geometrodynamic noise and suggest a statistical mechanical definition of gravitational entropy. We end with a brief discussion of the theoretical appropriateness to view the physical universe as an open system.

  1. Method for early detection of infectious mononucleosis

    DOE Patents [OSTI]

    Willard, K.E.

    1982-08-10

    Early detection of infectious mononucleosis is carried out using a sample of human blood by isolating and identifying the presence of Inmono proteins in the sample from a two-dimensional protein map with the proteins being characterized by having isoelectric banding as measured in urea of about -16 to -17 with respect to certain isoelectric point standards and molecular mass of about 70 to 75 K daltons as measured in the presence of sodium dodecylsulfate containing polyacrylamide gels, the presence of the Inmono proteins being correlated with the existence of infectious mononucleosis.

  2. Nucleosynthesis in Early Neutrino Driven Winds

    E-Print Network [OSTI]

    R. D. Hoffman; J. L. Fisker; J. Pruet; S. E. Woosley; H. -T. Janka; R. Buras

    2008-01-11

    Nucleosynthesis in early neutrino winds is investigated. Presented is a brief overview of two recent problems of supernova nucleosynthesis. In the first part we investigate the effect of nuclear parameters on the synthesis of Mo92 and Mo94. Based on recent experimental results, we find that the proton rich winds of the model investigated here can not be the source of solar Mo92 and Mo94. In the second part we investigate the nucleosynthesis from neutron rich bubbles and show that they do not contribute to the overall nucleosynthesis.

  3. Early planning for construction of Y-12

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would like submitKansas Nuclear Profile 2010Mesoscopy andSaving on Fuel The-EarlyHomeplanning

  4. Age and growth of red hind Epinephelus guttatus in

    E-Print Network [OSTI]

    analysis (Thompson and Munro 1974). However, neither study is recent and neither validated the ageing

  5. A Compositional and Dynamic Model for Face Aging

    E-Print Network [OSTI]

    Zhu, Song Chun

    A Compositional and Dynamic Model for Face Aging Jinli Suo, Song-Chun Zhu, Shiguang Shan, Member model for face aging. The compositional model represents faces in each age group by a hierarchical And.) crucial for age perception and Or nodes represent large diversity of faces by alternative selections

  6. Involvement in Early Childhood Special Education Among Chinese and Non-Chinese American Parents

    E-Print Network [OSTI]

    SooHoo, Tanya

    2012-01-01

    in early childhood special education: Opportunities forInvolvement in Early Childhood Special Education AmongInvolvement in Early Childhood Special Education Among

  7. Effect of Teacher-Child Interactions on Low-Income Children's Early Self-Regulation Development

    E-Print Network [OSTI]

    Hong, Sandra Lynn

    2012-01-01

    and development in early childhood education. In B. Spodek &of coursework in Early Childhood Education Advisor: Kathleenteaching in early childhood education through linked

  8. Can intensive early childhood intervention programs eliminate income- based cognitive and achievement gaps?

    E-Print Network [OSTI]

    Duncan, GJ; Sojourner, AJ

    2013-01-01

    Johnson. 2002. “Early Childhood Education: Young Adultcenter- based early childhood education intervention? DataI. Introduction Early childhood education programs are seen

  9. Identification of drug resistance mutations in HIV from constraints on natural evolution

    E-Print Network [OSTI]

    Butler, Thomas C; Kardar, Mehran; Chakraborty, Arup K

    2015-01-01

    Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its evolution is constrained by interactions between mutations in its fitness landscape. Here we show that an Ising model describing these interactions, inferred from sequence data obtained prior to the use of antiretroviral drugs, can be used to identify clinically significant sites of resistance mutations. Successful predictions of the resistance sites indicate progress in the development of successful models of real viral evolution at the single residue level, and suggest that our approach may be applied to help design new therapies that are less prone to failure even where resistance data is not yet available.

  10. ORISE: HIV/AIDS Information Resources from the National Library of Medicine

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesseworkSURVEY UNIVERSE TheForensic Science Forensic Science TheHIV/AIDS

  11. Direct tests of single-parameter aging

    E-Print Network [OSTI]

    Tina Hecksher; Niels Boye Olsen; Jeppe C. Dyre

    2015-06-12

    This paper presents accurate data for the physical aging of organic glasses just below the glass transition probed by monitoring the following quantities after temperature up and down jumps: the shear-mechanical resonance frequency (around 360 kHz), the dielectric loss at 1 Hz, the real part of the dielectric constant at 10 kHz, and the loss-peak frequency of the dielectric beta process (around 10 kHz). The setup used allows for keeping temperature constant within 100 micro Kelvin and for thermal equilibration within a few seconds after a temperature jump. The data conform to a new simplified version of the classical Tool-Narayanaswamy aging formalism, which makes it possible to calculate one relaxation curve directly from another without any fitting to analytical functions.

  12. Human Age Estimation From Skeletal and Dental Human Age Estimation From Skeletal and Dental

    E-Print Network [OSTI]

    Lucy, David

    and Section for Forensic Odontology, Oslo, Norway, for willingly providing what must be the world's most, likelihood, senescence, ageing, hard-tissue. Anthropologists and forensic scientists have found adult human

  13. Executive dysfunction in aging: Are Virtual Reality environments valid within the context of normal aging

    E-Print Network [OSTI]

    Webster, Holly E

    2008-06-27

    The objective of the current study was to assess how applicable developments in the use of virtual reality paradigms were in the studying of executive functioning within a normally aging sample. Traditional measures such as the Tower of London task...

  14. Critical Dynamics in the Early Universe

    E-Print Network [OSTI]

    B. L. Hu

    1993-02-22

    Methods and concepts for the study of phase transitions mediated by a time-dependent order-parameter field in curved spacetimes are discussed. A practical example is the derivation of an effective (quasi-)potential for the description of `slow-roll' inflation in the early universe. We first summarize our early results on viewing the symmetry behavior of constant background fields in curved but static spacetimes as finite size effect, and the use of derivative expansions for constructing effective actions for slowly-varying background fields. We then introduce the notion of dynamical finite size effect to explain how an exponential expansion of the scale factor imparts a finite size to the system and how the symmetry behavior in de Sitter space can be understood qualitatively in this light. We reason why the exponential inflation can be described equivalently by a scale transformation, thus rendering this special class of dynamics as effectively static. Finally we show how, in this view, one can treat the class of `slow-roll' inflation as a dynamic perturbation off the effectively static class of exponential inflation and understand it as a dynamical critical phenomenon in cosmology.

  15. Functional Neuroimaging Studies of Aging and Emotion 1 RUNNING HEAD: Functional Neuroimaging Studies of Aging and Emotion

    E-Print Network [OSTI]

    Cabeza, Roberto

    Functional Neuroimaging Studies of Aging and Emotion 1 RUNNING HEAD: Functional Neuroimaging Studies of Aging and Emotion Functional Neuroimaging Studies of Aging and Emotion: Fronto:peggy.st.jacques@duke.edu #12;Functional Neuroimaging Studies of Aging and Emotion 2 Abstract Emotional processes are enhanced

  16. Insights into accelerated aging of SSL luminaires

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Davis, J. Lynn; Lamvik, Michael; Bittle, James; Shepherd, Sarah; Yaga, Robert; Baldasaro, Nick; Solano, Eric; Bobashev, Georgiy

    2013-09-30

    Although solid-state lighting (SSL) products are often intended to have product lifetimes of 15 years or more, the rapid change in technology has created a need for accelerated life tests (ALTs) that can be performed in the span of several months. A critical element of interpreting results from any systems-level ALT is understanding of the impact of the test environment on each component. Because of its ubiquity in electronics, the use of temperature-humidity environments as potential ALTs for SSL luminaires was investigated. Results from testing of populations of three commercial 6” downlights in environments of 85oC and 85% relative humiditymore »(RH) and 75oC and 75% RH are reported. These test environments were found to accelerate lumen depreciation of the entire luminaire optical system, including LEDs, lenses, and reflectors. The effects of aging were found to depend strongly on both the optical materials that were used and the design of the luminaire; this shows that the lumen maintenance behavior of SSL luminaires must be addressed at the optical systems level. Temperature-Humidity ALTs can be a useful test in understand lumainaire depreciation provided that proper consideration is given to the different aging rates of various materials. Since the impact of the temperature-humidity environment varies among components of the optical system, uniform aging of all system components in a single test is difficult to achieve.« less

  17. Insights into accelerated aging of SSL luminaires

    SciTech Connect (OSTI)

    Davis, J. Lynn; Lamvik, Michael; Bittle, James; Shepherd, Sarah; Yaga, Robert; Baldasaro, Nick; Solano, Eric; Bobashev, Georgiy

    2013-09-30

    Although solid-state lighting (SSL) products are often intended to have product lifetimes of 15 years or more, the rapid change in technology has created a need for accelerated life tests (ALTs) that can be performed in the span of several months. A critical element of interpreting results from any systems-level ALT is understanding of the impact of the test environment on each component. Because of its ubiquity in electronics, the use of temperature-humidity environments as potential ALTs for SSL luminaires was investigated. Results from testing of populations of three commercial 6” downlights in environments of 85oC and 85% relative humidity (RH) and 75oC and 75% RH are reported. These test environments were found to accelerate lumen depreciation of the entire luminaire optical system, including LEDs, lenses, and reflectors. The effects of aging were found to depend strongly on both the optical materials that were used and the design of the luminaire; this shows that the lumen maintenance behavior of SSL luminaires must be addressed at the optical systems level. Temperature-Humidity ALTs can be a useful test in understand lumainaire depreciation provided that proper consideration is given to the different aging rates of various materials. Since the impact of the temperature-humidity environment varies among components of the optical system, uniform aging of all system components in a single test is difficult to achieve.

  18. Anti-Oxidants, Omega-3 Fatty Acids, and Cognitive Decline with Aging

    E-Print Network [OSTI]

    Patel, Tanu Ashok

    2011-01-01

    neurobiology of cognitive aging”. Ageing Research Reviewsinterventions. Neurobiology of Aging , 133-136. Cutler, R.1991). Antioxidants and aging. American Journal of Clinical

  19. Innovative practices in early childhood classrooms: what makes a teacher an early adopter? 

    E-Print Network [OSTI]

    Marshall, Ellen

    2004-09-30

    it into their teaching. The participants were all women who work in a variety of classroom settings with two-through-six-year-olds in San Antonio, Texas. They were identified as teachers who are in the forefront in adopting new ideas in comparison to other early...

  20. The ? Andromedae system: new constraints on the companion mass, system age, and further multiplicity

    SciTech Connect (OSTI)

    Hinkley, Sasha; David, Trevor; Hillenbrand, Lynne A.; Pueyo, Laurent; Faherty, Jacqueline K.; Oppenheimer, Ben R.; Brenner, Douglas; Veicht, Aaron; Nilsson, Ricky; Mamajek, Eric E.; Kraus, Adam L.; Rice, Emily L.; Ireland, Michael J.; Vasisht, Gautam; Cady, Eric; Roberts, Jennifer E.; Zimmerman, Neil; Parry, Ian R.; Beichman, Charles; Dekany, Richard; and others

    2013-12-20

    ? Andromedae is a B9IVn star at 52 pc for which a faint substellar companion separated by 55 ± 2 AU was recently announced. In this work, we present the first spectrum of the companion, '? And B,' using the Project 1640 high-contrast imaging platform. Comparison of our low-resolution YJH-band spectra to empirical brown dwarf spectra suggests an early-L spectral type. Fitting synthetic spectra from PHOENIX model atmospheres to our observed spectrum allows us to constrain the effective temperature to ?2000 K as well as place constraints on the companion surface gravity. Further, we use previously reported log(g) and T {sub eff} measurements of the host star to argue that the ? And system has an isochronal age of 220 ± 100 Myr, older than the 30 Myr age reported previously. This interpretation of an older age is corroborated by the photometric properties of ? And B, which appear to be marginally inconsistent with other 10-100 Myr low-gravity L-dwarfs for the spectral type range we derive. In addition, we use Keck aperture masking interferometry combined with published radial velocity measurements to rule out the existence of any tight stellar companions to ? And A that might be responsible for the system's overluminosity. Further, we show that luminosity enhancements due to a nearly 'pole-on' viewing angle coupled with extremely rapid rotation is unlikely. ? And A is thus consistent with its slightly evolved luminosity class (IV), and we propose here that ? And, with a revised age of 220 ± 100 Myr, is an interloper to the 30 Myr Columba association with which it was previously associated. The photometric and spectroscopic evidence for ? And B combined with our reassessment of the system age implies a substellar companion mass of 50{sub ?13}{sup +16} M {sub Jup}, consistent with a brown dwarf rather than a planetary-mass companion.

  1. Epidemiologic Features of Vaginal Infections among Reproductive-age Women in South India

    E-Print Network [OSTI]

    Rathod, Sujit D.

    2012-01-01

    their treatment in south India. Stud Fam Plann. 1995; 26(4):married women in Tamil Nadu, India. Int Fam Plan Perspect.infections and HIV in India. Sex Transm Infect 2002; 78

  2. Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Luo, Shishi; Perelson, Alan S.

    2015-08-31

    The past decade has seen the discovery of numerous broad and potent monoclonal antibodies against HIV type 1 (HIV-1). Eliciting these antibodies via vaccination appears to be remarkably difficult, not least because they arise late in infection and are highly mutated relative to germline antibody sequences. Here, using a computational model, we show that broad antibodies could in fact emerge earlier and be less mutated, but that they may be prevented from doing so as a result of competitive exclusion by the autologous antibody response. We further find that this competitive exclusion is weaker in infections founded by multiple distinctmore »strains, with broadly neutralizing antibodies emerging earlier than in infections founded by a single strain. Our computational model simulates coevolving multitype virus and antibody populations. Broadly neutralizing antibodies may therefore be easier for the adaptive immune system to generate than previously thought. As a result, if less mutated broad antibodies exist, it may be possible to elicit them with a vaccine containing a mixture of diverse virus strains.« less

  3. Improving the Anti-HIV Potency of Different Compounds through Synergy and Covalent Linkage: Dimerization Studies of CXCL8 

    E-Print Network [OSTI]

    Kagiampakis, Ioannis

    2011-10-21

    In the first part of my dissertation we focused on the development of covalently linking compounds that bind gp120 with those that bind gp41 in order to block HIV fusion. We used griffithsin or CD4M33, that both bind to gp120, covalently linked...

  4. HIV-1 Tat membrane interactions probed using X-ray and neutron scattering, CD spectroscopy and MD simulations

    E-Print Network [OSTI]

    Nagle, John F.

    HIV-1 Tat membrane interactions probed using X-ray and neutron scattering, CD spectroscopy and MD translocation, were provided by wide-angle X-ray scattering (WAXS) and neutron scattering. CD spectroscopy for Neutron Research, 100 Bureau Drive, Stop 6102, Gaithersburg, MD 20899, United States d CHESS, Cornell

  5. Supplementary data for HIV-1 Tat membrane interaction probed using X-ray and neutron scattering, CD, and MD simulations

    E-Print Network [OSTI]

    Nagle, John F.

    1 Supplementary data for HIV-1 Tat membrane interaction probed using X-ray and neutron scattering- spacing are linearly related. Figure S3. Neutron scattering from stacks of DOPC:DOPE (3:1)/Tat, x=0 of Physics, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, NY 12180, 3 NIST Center for Neutron

  6. Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility

    E-Print Network [OSTI]

    , Brazil 2 Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA Although a majority of HIV-1 infections in Brazil are caused by the subtype B virus (also prevalent in the United States and Western Europe), viral subtypes F and C are also

  7. Free Energy Component Analysis for Drug Design: A Case Study of HIV-1 Protease-Inhibitor Binding

    E-Print Network [OSTI]

    Jayaram, Bhyravabotla

    Free Energy Component Analysis for Drug Design: A Case Study of HIV-1 Protease-Inhibitor Binding of the free energies of binding of protein-ligand complexes is presented. The method formulated involves, and the trajectories were analyzed via a thermodynamic cycle to calculate the binding free energies. The computed free

  8. Estimating the Size of Populations at High Risk of HIV in Bangladesh Using a Bayesian Hierarchical Model

    E-Print Network [OSTI]

    Washington at Seattle, University of

    Estimating the Size of Populations at High Risk of HIV in Bangladesh Using a Bayesian Hierarchical the numbers of injecting drug users and female sex workers in Bangladesh. Contents 1 Introduction 1 2 Methods of Intravenous Drug Users in Bangladesh in 2004 7 3.1 Results from the multiplier method

  9. On Axion Thermalization in the Early Universe

    E-Print Network [OSTI]

    Eduard Masso; Francesc Rota; Gabriel Zsembinszki

    2002-05-24

    We reanalyze the conditions under which we have a primordial thermal population of axions. Compared with previous studies, we find other processes, involving gluons and quarks, that dominate at high temperatures. We conclude that if the Peccei-Quinn scale fulfills $F_a < 1.2 \\times 10^{12} \\GeV$ there is thermal axion production. In this case, a period in the early universe exists where axions interact with the QCD plasma and we point out that non-thermal axions produced before the end of this period will thermalize. This could lead to a reduction of the expected density of axions from string decay in models with $F_a < 1.2 \\times 10^{12} \\GeV$.

  10. Hidden AGNs in Early-Type Galaxies

    E-Print Network [OSTI]

    Paggi, A; Civano, F; Pellegrini, S; Elvis, M; Kim, D -W

    2015-01-01

    We present a stacking analysis of the complete sample of Early Type Galaxies (ETGs) in the \\textit{Chandra} COSMOS (C-COSMOS) survey, to explore the nature of the X-ray luminosityin the redshift and stellar luminosity ranges \\(0gas}\\propto L_K^{4.5}\\) for hot gaseous halos emission in ETGs, and (2) evaluate the spectral signature of each stacked bin. We find two regimes where the non-stellar X-ray emission is hard, consistent with AGN emission. First, there is evidence of hard, absorbed X-ray emission in stacked bins including relatively high z (\\(\\sim 1.2\\)) ETGs with average high X-ray luminosity (\\(L_{X-LMXB}\\gtrsim 6\\times{10}^{42}\\mbox{ er...

  11. Early Identification of Violent Criminal Gang Members

    E-Print Network [OSTI]

    Shaabani, Elham; Shakarian, Paulo; Bertetto, John

    2015-01-01

    Gang violence is a major problem in the United States accounting for a large fraction of homicides and other violent crime. In this paper, we study the problem of early identification of violent gang members. Our approach relies on modified centrality measures that take into account additional data of the individuals in the social network of co-arrestees which together with other arrest metadata provide a rich set of features for a classification algorithm. We show our approach obtains high precision and recall (0.89 and 0.78 respectively) in the case where the entire network is known and out-performs current approaches used by law-enforcement to the problem in the case where the network is discovered overtime by virtue of new arrests - mimicking real-world law-enforcement operations. Operational issues are also discussed as we are preparing to leverage this method in an operational environment.

  12. Thermodynamics in the Viscous Early Universe

    E-Print Network [OSTI]

    Tawfik, A

    2010-01-01

    Assuming that the matter filling the background geometry in the Early Universe was a free gas and no phase transitions took place, we discuss the thermodynamics of this closed system using classical approaches. We found that essential cosmological quantities, such as the Hubble parameter $H$, the scaling factor $a$ and the curvature parameter $k$, can be derived from this simple model. The results are compatible with the Friedmann-Robertson-Walker model and Einstein field equations. Including finite bulk viscosity coefficient leads to important changes in the cosmological quantities. Accordingly, our picture about evolution of the Universe and its astrophysical consequences seems to be a subject of radical revision. We found that $k$ strongly depends on thermodynamics of the cosmic background matter. The time scale, at which negative curvature might take place, depends on the relation between the matter content and the total energy. Using quantum and statistical approaches, we introduced expressions for $H$ a...

  13. Discovering colorons at the early stage LHC

    SciTech Connect (OSTI)

    Dicus, Duane A. [Center for Particles and Fields and Texas Cosmology Center, University of Texas, Austin, Texas 78712 (United States); Kao, Chung; Sayre, Joshua [Homer L. Dodge Department of Physics and Astronomy and Oklahoma Center for High Energy Physics, University of Oklahoma, Norman, Oklahoma 73019 (United States); Nandi, S. [Department of Physics and Oklahoma Center for High Energy Physics, Oklahoma State University, Stillwater, Oklahoma 74078 (United States)

    2011-05-01

    Prospects are investigated for the discovery of massive hypergluons using data from the early runs of the Large Hadron Collider. A center of mass energy of 7 TeV and an integrated luminosity of 1 fb{sup -1} or 5 fb{sup -1} are assumed. A phenomenological Lagrangian is adopted to evaluate the cross section of a pair of colored vector bosons (colorons, {rho}-tilde) decaying into four colored scalar resonances (hyperpions, {pi}-tilde), which then decay into eight gluons. The dominant eight-jet background from the production of 8g, 7g1q, 6g2q, and 5g3q is included. We find an abundance of signal events and that realistic cuts reduce the background enough to establish a 5{sigma} signal for the coloron mass of up to 733 GeV with 1 fb{sup -1} or 833 GeV with 5 fb{sup -1}.

  14. Aging analyses of aircraft wire insulation

    SciTech Connect (OSTI)

    GILLEN,KENNETH T.; CLOUGH,ROGER LEE; CELINA,MATHIAS C.; AUBERT,JAMES H.; MALONE,G. MICHAEL

    2000-05-08

    Over the past two decades, Sandia has developed a variety of specialized analytical techniques for evaluating the long-term aging and stability of cable insulation and other related materials. These techniques have been applied to cable reliability studies involving numerous insulation types and environmental factors. This work has allowed the monitoring of the occurrence and progression of cable material deterioration in application environments, and has provided insights into material degradation mechanisms. It has also allowed development of more reliable lifetime prediction methodologies. As a part of the FAA program for intrusive inspection of aircraft wiring, they are beginning to apply a battery of techniques to assessing the condition of cable specimens removed from retired aircraft. It is anticipated that in a future part of this program, they may employ these techniques in conjunction with accelerated aging methodologies and models that the authros have developed and employed in the past to predict cable lifetimes. The types of materials to be assessed include 5 different wire types: polyimide, PVC/Glass/Nylon, extruded XL-polyalkene/PVDF, Poly-X, and XL-ETFE. This presentation provides a brief overview of the main techniques that will be employed in assessing the state of health of aircraft wire insulation. The discussion will be illustrated with data from their prior cable aging studies, highlighting the methods used and their important conclusions. A few of the techniques that they employ are widely used in aging studies on polymers, but others are unique to Sandia. All of their techniques are non-proprietary, and maybe of interest for use by others in terms of application to aircraft wiring analysis. At the end of this report is a list showing some leading references to papers that have been published in the open literature which provide more detailed information on the analytical techniques for elastomer aging studies. The first step in the investigation of aircraft wiring is to evaluate the applicability of their various techniques to aircraft cables, after which they expect to identify a limited subset of techniques which are appropriate for each of the major aircraft wiring types. The techniques of initial interest in the studies of aging aircraft wire are as follows: optical microscopy; mandrel bend test; tensile test/elongation at break; density measurements; modulus profiling/(spatially-resolved micro-hardness); oxygen induction time/oxygen induction temperature (by differential scanning calorimetry); solvent-swelling/gel fraction; infrared spectroscopy (with chemical derivatization as warranted); chemiluminescence; thermo-oxidative wear-out assessment; The first two techniques are the simplest and quickest to apply; those further down the list tend to be more information rich and in some cases more sensitive, but also generally more specialized and more time consuming to run. Accordingly, the procedure will be to apply the simplest tests for purposes of preliminary screening of large numbers of samples. For any given material type, it can be expected that only a limited number of the other techniques will prove to be useful, and therefore, the more specialized techniques will be used on a limited number of selected samples. Samples of aircraft wiring have begun to be released to the authors in late April; they include in this report some limited and preliminary data on these materials.

  15. On the seismic age of the Sun

    E-Print Network [OSTI]

    G. Houdek; D. O. Gough

    2007-10-03

    We use low-degree acoustic modes obtained by the BiSON to estimate the main-sequence age $t_\\odot$ of the Sun. The calibration is accomplished by linearizing the deviations from a standard solar model the seismic frequencies of which are close to those of the Sun. Formally, we obtain the preliminary value $t_\\odot=4.68\\pm0.02 $Gy, coupled with an initial heavy-element abundance $Z=0.0169\\pm0.0005$. The quoted standard errors, which are not independent, are upper bounds implied under the assumption that the standard errors in the observed frequencies are independent.

  16. Asian Age Enterprise Ltd | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar Energy LLC Jump to: navigation,SummariesAshman Technologies JumpAge

  17. Rock of Ages | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION JEnvironmental Jump to:EA EIS Report UrlNM-bRenewable Energy|Gas and Electricof Ages Jump to:

  18. AGE UFMG Incubator | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION JEnvironmental Jump to:EAand Dalton JumpProgram |RecentSulfonateAFV SolutionsEnergyOpenAGE UFMG

  19. HI in Low-Luminosity Early-Type Galaxies

    E-Print Network [OSTI]

    Tom Oosterloo; Raffaella Morganti; Elaine Sadler

    1998-09-07

    We discuss the properties of the HI in low-luminosity early-type galaxies. The morphology of the HI is more regular than that of the HI in many more-luminous early-type galaxies. The HI is always distributed in a disk and is more centrally concentrated. The central HI surface densities are higher than in luminous early-type galaxies and are high enough for star formation to occur.

  20. ASCR Researchers Honored With a Presidential Early Career Award...

    Office of Science (SC) Website

    Researchers Honored With a Presidential Early Career Award Advanced Scientific Computing Research (ASCR) ASCR Home About Research Facilities Science Highlights Benefits of ASCR...

  1. Memorandum of Understanding on early coordination of federal...

    Office of Environmental Management (EM)

    of federal authorizations and related environmental reviews required in order to site electric transmission facilities: August 2006 Memorandum of Understanding on early...

  2. Early science with the large millimeter telescope: exploring...

    Office of Scientific and Technical Information (OSTI)

    Early science with the large millimeter telescope: exploring the effect of AGN activity on the relationships between molecular gas, dust, and star formation Citation Details...

  3. Activation of the metabolic sensor-AMP activated protein kinase reverses impairment of angiogenesis in aging myocardial microvascular endothelial cells. Implications for the aging heart.

    E-Print Network [OSTI]

    Ahluwalia, A; Tarnawski, A S

    2011-01-01

    AS. Impaired angiogenesis in aging myocardial microvascularprotein kinase enzyme in aging myocardial microvascularphosphorylated) AMPK in aging MMECs 2.1-fold (P<0.01) vs.

  4. Effect of voluntary counselling and testing and a negative HIV result on risk behaviour: a qualitative longitudinal study in a Zambian mining community 

    E-Print Network [OSTI]

    Sikasote, Janet Precious Banda

    2010-01-01

    Background: Countries in sub-Saharan Africa are scaling up access to Voluntary Counselling and Testing (VCT) services as a strategy for HIV prevention, treatment, care and support. The international and national push to ...

  5. Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge Even at Low Serum Neutralizing Titers

    E-Print Network [OSTI]

    2009-01-01

    the HIV-DC-SIGN interaction in blocking transmission couldDC-SIGN binding and that this correlates with enhanced mucosal transmissionDC- SIGN, which has been proposed to have a critical role in transmission

  6. An evaluation of novel lipid-enveloped nanoparticles for adjuvant and antigen delivery for an HIV vaccine : stepping from laboratory into potential markets

    E-Print Network [OSTI]

    Khodami, Pantea

    2011-01-01

    Enormous effort has been devoted to the development of a vaccine against human immunodeficiency virus (HIV). The purpose of this paper is to evaluate the technological and economical aspects of a potential vaccine designed ...

  7. Shamba Maisha: A pilot study assessing impacts of a micro-irrigation intervention on the health and economic wellbeing of HIV patients

    E-Print Network [OSTI]

    Pandit, Jay A; Sirotin, Nicole; Tittle, Robin; Onjolo, Elijah; Bukusi, Elizabeth A; Cohen, Craig R

    2010-01-01

    of providing a micro-irrigation pump to HIV-positive farmersloan to receive an irrigation pump and farming guidance froma low-cost micro-irrigation pump which is purchased by local

  8. Constructing loss : exploring the traumatic effects of bereavement due to HIV/AIDS and tuberculosis on aid workers in South Africa 

    E-Print Network [OSTI]

    Ranjbar, Vania

    2013-07-02

    This thesis aimed to investigate, first, the potentially traumatic effects of AIDS-related bereavement on HIV/AIDS aid workers in South Africa; second, the resources that aid workers utilise in order to cope with their ...

  9. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Enzyme Structure Provides Insights into Cancer and Aging Enzyme Structure Provides Insights into Cancer and Aging Print Wednesday, 25 February 2009 00:00 XPD helicase is an enzyme...

  10. Sean; Tanner, Danelle Mary 47 OTHER INSTRUMENTATION; AGING; SENSORS...

    Office of Scientific and Technical Information (OSTI)

    an aging experiment that was established in FY09 and completed in FY10 for the Sandia MEMS Passive Shock Sensor. A total of 37 packages were aged at different temperatures and...

  11. Age Dating of Mixed SNM--Preliminary Investigations

    SciTech Connect (OSTI)

    Yuan, D., Guss, P. P., Yfantis, E., Klingensmith, A., Emer, D.

    2011-12-01

    Recently we investigated the nuclear forensics problem of age determination for mixed special nuclear material (SNM). Through limited computational mixing experiments and interactive age analysis, it was observed that age dating results are generally affected by the mixing of samples with different assays or even by small radioactive material contamination. The mixing and contamination can be detected through interactive age analysis, a function provided by the Decay Interaction, Visualization and Analysis (DIVA) software developed by NSTec. It is observed that for mixed SNM with two components, the age estimators typically fall into two distinct clusters on the time axis. This suggests that averaging or other simple statistical methods may not always be suitable for age dating SNM mixtures. Instead, an interactive age analysis would be more suitable for age determination of material components of such SNM mixtures. This work was supported by the National Center for Nuclear Security (NCNS).

  12. Fact #614: March 15, 2010 Average Age of Household Vehicles

    Broader source: Energy.gov [DOE]

    The average age of household vehicles has increased from 6.6 years in 1977 to 9.2 years in 2009. Pickup trucks have the oldest average age in every year listed. Sport utility vehicles (SUVs), first...

  13. Managing Aging Effects on Dry Cask Storage Systems for Extended...

    Office of Environmental Management (EM)

    Managing Aging Effects on Dry Cask Storage Systems for Extended Long Term Storage and Transportation of Used Fuel Rev0 Managing Aging Effects on Dry Cask Storage Systems for...

  14. THE EFFECTS OF HIV INFECTION ON THE EXPRESSION OF THE DRUG EFFLUX PROTEINS P-GLYCOPROTEIN AND BREAST CANCER RESISTANCE PROTEIN IN A HUMAN INTESTINE MODEL

    E-Print Network [OSTI]

    Ellis, Kelstan Lynch

    2012-08-31

    and Public Health and the Graduate Faculty of the University of Kansas in partial fulfillment of the requirements for the degree of Master of Science in Clinical Research. ________________________________ Chairperson Edward F. Ellerbeck, MD, MPH...), infected with HIV and used to propogate the CXCR4-tropic LAI strain of HIV. MDCK-MDR1 cells were a generous gift from Dr. Jeff Krise (University of Kansas School of Pharmacy, Lawrence, KS). This cell line originates from Madin Darby canine kidney cells...

  15. 2014 Healthy Aging Alliance Conference "Harnessing Science and Communities

    E-Print Network [OSTI]

    Chapman, Michael S.

    2014 Healthy Aging Alliance Conference "Harnessing Science and Communities for Healthy Brain Aging:45 ­ 4:45 pm Hosted by the OHSU Healthy Aging Alliance in Partnership with: Portland State UniversityDigitalPhotos.net Alliance Co-Chairs Elizabeth Eckstrom, MD, MPH eckstrom@ohsu.edu Henryk Urbanski, PhD, DSc urbanski

  16. Virtual Age: Enabling Technologies and Trends Hamid Mahmoodi 1

    E-Print Network [OSTI]

    Mahmoodi, Hamid

    . This much-needed breakthrough manifested itself in the form of the industrial revolution. Industrial revolution signaled the end of the Agricultural Age and moved the human society forward towards the Industrial Age which lasted for about 500 years. In this age, great inventions, such as, the steam engine

  17. Surface Aging by Impacts Eric Paquettea,b

    E-Print Network [OSTI]

    Montréal, Université de

    Surface Aging by Impacts Eric Paquettea,b Pierre Poulina George Drettakisb a LIGUM DIRO, Universit aging technique that simulates the deformation of an object caused by repetitive impacts over long aging effects of repetitive impacts, significantly in- creasing their realism. Key words: Realism

  18. Aging and Complexity in Equilibrium Dynamics K. Ehrenberger

    E-Print Network [OSTI]

    Svozil, Karl

    Aging and Complexity in Equilibrium Dynamics K. Ehrenberger ENT Department, University of Vienna W age, the fractal dimension of the graph of postural stability decreases. From the many aspects of aging, the possible loss of complexity of cer- tain physiological functions and processes is seldomly

  19. Aging, Estrogen Loss and Epoxyeicosatrienoic Acids Alison R. Lee1.

    E-Print Network [OSTI]

    Hammock, Bruce D.

    Aging, Estrogen Loss and Epoxyeicosatrienoic Acids (EETs) Alison R. Lee1. , Angela S. Pechenino1 loss, caused by menopause, and aging have inflammatory consequences. Epoxyeicosatrienoic acids (EETs cyclooxygenases and lipoxygenases. We hypothesized that aging and estrogen loss would reduce levels of anti

  20. Aging and Complexity in Equilibrium Dynamics K. Ehrenberger

    E-Print Network [OSTI]

    Svozil, Karl

    Aging and Complexity in Equilibrium Dynamics K. Ehrenberger ENT Department, University of Vienna W With increasing age, the fractal dimension of the graph of postural stability decreases. From the many aspects of aging, the possible loss of complexity of cer­ tain physiological functions and processes is seldomly

  1. Emerging perspectives in social neuroscience and neuroeconomics of aging

    E-Print Network [OSTI]

    Mather, Mara

    Emerging perspectives in social neuroscience and neuroeconomics of aging Lisbeth Nielsen1 and Mara Mather2 1 Division of Behavioral and Social Research, National Institute on Aging/National Institutes and Affective Neuroscience on Aging Research, and offers a broad conceptual and methodological framework

  2. A Markovian, Variation-Aware Circuit-Level Aging Model

    E-Print Network [OSTI]

    Cotofana, Sorin

    A Markovian, Variation-Aware Circuit-Level Aging Model Nicoleta Cucu Laurenciu, and Sorin Dan.CucuLaurenciu, S.D.Cotofana}@tudelft.nl Abstract--Accurate age modeling, and fast, yet robust relia- bility sign at design-time appropriate guardbands selection and effective aging mitigation/compensation techniques

  3. Minute Effects of Sex on the Aging Brain: A Multisample Magnetic Resonance Imaging Study of Healthy Aging and Alzheimer's Disease

    E-Print Network [OSTI]

    Fjell, Anders M.

    Age is associated with substantial macrostructural brain changes. While some recent magnetic resonance imaging studies have reported larger age effects in men than women, others find no sex differences. As brain morphometry ...

  4. Water delivery in the Early Solar System

    E-Print Network [OSTI]

    Dvorak, Rudolf; Süli, Áron; Sándor, Zsolt; Galiazzo, Mattia; Pilat-Lohinger, Elke

    2015-01-01

    As part of the national scientific network 'Pathways to Habitable Worlds' the delivery of water onto terrestrial planets is a key question since water is essential for the development of life as we know it. After summarizing the state of the art we show some first results of the transport of water in the early Solar System for scattered main belt objects. Hereby we investigate the questions whether planetesimals and planetesimal fragments which have gained considerable inclination due to the strong dynamical interactions in the main belt region around 2 AU can be efficient water transporting vessels. The Hungaria asteroid group is the best example that such scenarios are realistic. Assuming that the gas giants and the terrestrial planets are already formed, we monitor the collisions of scattered small bodies containing water (in the order of a few percent) with the terrestrial planets. Thus we are able to give a first estimate concerning the respective contribution of such bodies to the actual water content i...

  5. Risk of Cerebrovascular Events in Elderly Patients After Radiation Therapy Versus Surgery for Early-Stage Glottic Cancer

    SciTech Connect (OSTI)

    Hong, Julian C.; Kruser, Tim J.; Gondi, Vinai; Mohindra, Pranshu; Cannon, Donald M.; Harari, Paul M.; Bentzen, Søren M.

    2013-10-01

    Purpose: Comprehensive neck radiation therapy (RT) has been shown to increase cerebrovascular disease (CVD) risk in advanced-stage head-and-neck cancer. We assessed whether more limited neck RT used for early-stage (T1-T2 N0) glottic cancer is associated with increased CVD risk, using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database. Methods and Materials: We identified patients ?66 years of age with early-stage glottic laryngeal cancer from SEER diagnosed from 1992 to 2007. Patients treated with combined surgery and RT were excluded. Medicare CPT codes for carotid interventions, Medicare ICD-9 codes for cerebrovascular events, and SEER data for stroke as the cause of death were collected. Similarly, Medicare CPT and ICD-9 codes for peripheral vascular disease (PVD) were assessed to serve as an internal control between treatment groups. Results: A total of 1413 assessable patients (RT, n=1055; surgery, n=358) were analyzed. The actuarial 10-year risk of CVD was 56.5% (95% confidence interval 51.5%-61.5%) for the RT cohort versus 48.7% (41.1%-56.3%) in the surgery cohort (P=.27). The actuarial 10-year risk of PVD did not differ between the RT (52.7% [48.1%-57.3%]) and surgery cohorts (52.6% [45.2%-60.0%]) (P=.89). Univariate analysis showed an increased association of CVD with more recent diagnosis (P=.001) and increasing age (P=.001). On multivariate Cox analysis, increasing age (P<.001) and recent diagnosis (P=.002) remained significantly associated with a higher CVD risk, whereas the association of RT and CVD remained not statistically significant (HR=1.11 [0.91-1.37,] P=.31). Conclusions: Elderly patients with early-stage laryngeal cancer have a high burden of cerebrovascular events after surgical management or RT. RT and surgery are associated with comparable risk for subsequent CVD development after treatment in elderly patients.

  6. Dark Energy in the Dark Ages

    E-Print Network [OSTI]

    Eric V. Linder

    2006-04-11

    Non-negligible dark energy density at high redshifts would indicate dark energy physics distinct from a cosmological constant or ``reasonable'' canonical scalar fields. Such dark energy can be constrained tightly through investigation of the growth of structure, with limits of \\la2% of total energy density at z\\gg1 for many models. Intermediate dark energy can have effects distinct from its energy density; the dark ages acceleration can be constrained to last less than 5% of a Hubble e-fold time, exacerbating the coincidence problem. Both the total linear growth, or equivalently \\sigma_8, and the shape and evolution of the nonlinear mass power spectrum for zenergy behavior over the entire range z=0-1100.

  7. Accelerated Aging of Polymer Composite Bridge Materials

    SciTech Connect (OSTI)

    Carlson, Nancy Margaret; Blackwood, Larry Gene; Torres, Lucinda Laine; Rodriguez, Julio Gallardo; Yoder, Timothy Scott

    1999-03-01

    Accelerated aging research on samples of composite material and candidate ultraviolet (UV) protective coatings is determining the effects of six environmental factors on material durability. Candidate fastener materials are being evaluated to determine corrosion rates and crevice corrosion effects at load-bearing joints. This work supports field testing of a 30-ft long, 18-ft wide polymer matrix composite (PMC) bridge at the Idaho National Engineering and Environmental Laboratory (INEEL). Durability results and sensor data from tests with live loads provide information required for determining the cost/benefit measures to use in life-cycle planning, determining a maintenance strategy, establishing applicable inspection techniques, and establishing guidelines, standards, and acceptance criteria for PMC bridges for use in the transportation infrastructure.

  8. Passive absolute age and temperature history sensor

    SciTech Connect (OSTI)

    Robinson, Alex; Vianco, Paul T.

    2015-11-10

    A passive sensor for historic age and temperature sensing, including a first member formed of a first material, the first material being either a metal or a semiconductor material and a second member formed of a second material, the second material being either a metal or a semiconductor material. A surface of the second member is in contact with a surface of the first member such that, over time, the second material of the second member diffuses into the first material of the first member. The rate of diffusion for the second material to diffuse into the first material depends on a temperature of the passive sensor. One of the electrical conductance, the electrical capacitance, the electrical inductance, the optical transmission, the optical reflectance, or the crystalline structure of the passive sensor depends on the amount of the second material that has diffused into the first member.

  9. Early History of Algebra and Geometry Modern History

    E-Print Network [OSTI]

    Tribute Early History of Algebra and Geometry Modern History From Algebraic to Weak Subintegral. Vitulli Algebraic to Subintegral Extensions #12;Tribute Early History of Algebra and Geometry Modern History Etta Zuber Falconer (1933 - 2002) "My entire career has been devoted to increasing the number

  10. Early Childhood Education Center 1650 Holloway Avenue, CCSC M-102

    E-Print Network [OSTI]

    Early Childhood Education Center 1650 Holloway Avenue, CCSC M-102 San Francisco, CA 94132 (415) 338 Permit? Yes No CPR/First aid Yes No Early Childhood Education (ECE) and/or Child Development (CD in this country? Yes No EMPLOYER NAME and LOCATION POSITION and DUTIES FROM TO 3. Education Child Development

  11. Forest Fire Modeling and Early Detection using Wireless Sensor Networks

    E-Print Network [OSTI]

    Zhang, Richard "Hao"

    Forest Fire Modeling and Early Detection using Wireless Sensor Networks MOHAMED HEFEEDA Simon Fraser University, Canada Forest fires cost millions of dollars in damages and claim many human lives for early detection of forest fires. We first present the key aspects in modeling forest fires. We do

  12. Early molecular responses of coral larvae to hyperthermal stress

    E-Print Network [OSTI]

    suggests that heat stress might compromise some components of the coral immune defence and therefore might oxidative stress showed little response at the early hours to heat stress, supporting the proposal that upEarly molecular responses of coral larvae to hyperthermal stress MAURICIO RODRIGUEZ-LANETTY,* SAKI

  13. Early Warning System on a National Level Project AMSEL

    E-Print Network [OSTI]

    Flegel, Ulrich

    Early Warning System on a National Level ­ Project AMSEL Martin Apel, Joachim Biskup, Ulrich Flegel.biskup, michael.meier@cs.tu-dortmund.de SAP Research, Vincenz-Prießnitz-Str. 1, 76131 Karlsruhe, Germany ulrich.flegel@sap.com Abstract We present the architecture of an automatic early warning system (EWS) that aims at providing

  14. Application to the Early Entry PhD Option Instructions

    E-Print Network [OSTI]

    Sheridan, Jennifer

    Application to the Early Entry PhD Option Instructions: 1. TYPE required information. (You to the Academic Programs Office: Attention: Carol Aspinwall, Coordinator of PhD Program Academic Student Services that describes your reasons for seeking admission to the Early Entry PhD Option. APPROVAL (For office use only

  15. Early Power Grid Verification Under Circuit Current Uncertainties

    E-Print Network [OSTI]

    Najm, Farid N.

    Early Power Grid Verification Under Circuit Current Uncertainties Imad A. Ferzli Department of ECE Eindhoven, The Netherlands lars@magma-da.com ABSTRACT As power grid safety becomes increasingly important in modern integrated circuits, so does the need to start power grid verifica- tion early in the design cycle

  16. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  17. Similarity-Index Early Seizure Detector VLSI Architecture

    E-Print Network [OSTI]

    Genov, Roman

    Similarity-Index Early Seizure Detector VLSI Architecture Amogh Vidwans, Karim Abdelhalim, Roman: {roman}@eecg.utoronto.ca Abstract-- A low power VLSI architecture implementing an algorithm for early by intractable epilepsy, and neurologists believe that stimulating the right neuronal cells with short electrical

  18. Tsunami early warning using earthquake rupture duration Anthony Lomax1

    E-Print Network [OSTI]

    Rawlinson, Nick

    Tsunami early warning using earthquake rupture duration Anthony Lomax1 and Alberto Michelini2] Effective tsunami early warning for coastlines near a tsunamigenic earthquake requires notification within 5, greater than about 50 s. Here we show that T0 gives more information on tsunami importance than moment

  19. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3

    SciTech Connect (OSTI)

    Kula, Anna; Gharu, Lavina [The Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34012 Trieste (Italy)] [The Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34012 Trieste (Italy); Marcello, Alessandro, E-mail: marcello@icgeb.org [The Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34012 Trieste (Italy)] [The Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34012 Trieste (Italy)

    2013-01-20

    Human immunodeficiency virus gene expression and replication are regulated at several levels. Incompletely spliced viral RNAs and full-length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. Previously we found that the nuclear matrix protein MATR3 was a cofactor of Rev-mediated RNA export. Here we show that the pleiotropic protein PSF binds viral RNA and is associated with MATR3. PSF is involved in the maintenance of a pool of RNA available for Rev activity. However, while Rev and PSF bind the viral pre-mRNA at the site of viral transcription, MATR3 interacts at a subsequent step. We propose that PSF and MATR3 define a novel pathway for RRE-containing HIV-1 RNAs that is hijacked by the viral Rev protein.

  20. Aging management guideline for commercial nuclear power plants - heat exchangers

    SciTech Connect (OSTI)

    Booker, S.; Lehnert, D.; Daavettila, N.; Palop, E.

    1994-06-01

    This Aging Management Guideline (AMG) describes recommended methods for effective detection and mitigation of age-related degradation mechanisms in commercial nuclear power plant heat exchangers important to license renewal. The intent of this AMG is to assist plant maintenance and operations personnel in maximizing the safe, useful life of these components. It also supports the documentation of effective aging management programs required under the License Renewal Rule 10 CFR 54. This AMG is presented in a manner that allows personnel responsible for performance analysis and maintenance to compare their plant-specific aging mechanisms (expected or already experienced) and aging management program activities to the more generic results and recommendations presented herein.

  1. What is the state of the Early Universe?

    E-Print Network [OSTI]

    Samir D. Mathur

    2008-03-27

    As we follow our Universe to early times, we find that matter was crushed to high densities, somewhat similar to the behavior at a black hole singularity. String theory has made progress in explaining the internal structure of black holes, so we would like to extrapolate the ideas learnt from black holes to the early Universe. If we assume that we want the most probable state of the Universe at early times, then we should look at the kind of state that describes a generic black hole. This suggests a definite equation of state for the matter in the early Universe. Quantum effects can stretch across macroscopic distances in black holes, and these might be important in understanding the early Universe as well.

  2. The Early Angular Momentum History of Low Mass Stars: Evidence for a Regulation Mechanism

    E-Print Network [OSTI]

    L. M. Rebull; S. C. Wolff; S. E. Strom; R. B. Makidon

    2002-03-21

    We examine the early angular momentum history of stars in young clusters via 197 photometric periods in fields flanking the Orion Nebula Cluster (ONC), 81 photometric periods in NGC 2264, and 202 measurements of v sin i in the ONC itself. We show that PMS stars spanning an age range from 0.1 to 3 Myr do not appear to conserve stellar angular momentum as they evolve down their convective tracks, but instead preserve the same range of periods even though they have contracted by about a factor of three. This result seems to require a mechanism that regulates the angular velocities of young stars. We discuss several candidate mechanisms. The most plausible appears to be disk-locking, though most of our stars do not have (I-K) excesses suggestive of disks. However, a decisive test of this hypothesis requires a more sensitive diagnostic than the (I-K) excesses used here.

  3. Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bhattacharya, Akash; Alam, Steven L.; Fricke, Thomas; Zadrozny, Kaneil; Sedzicki, Jaroslaw; Taylor, Alexander B.; Demeler, Borries; Pornillos, Owen; Ganser-Pornillos, Barbie K.; Diaz-Griffero, Felipe; et al

    2014-12-17

    Upon infection of susceptible cells by HIV-1, the conical capsid formed by ~250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. In this study, the capsid shields the RNA genome and proteins required for reverse transcription. In addition, the surface of the capsid mediates numerous host–virus interactions, which either promote infection or enable viral restriction by innate immune responses. In the intact capsid, there is an intermolecular interface between the N-terminal domain (NTD) of one subunit and the C-terminal domain (CTD) of the adjacent subunit within the same hexameric ring. The NTD–CTD interface is criticalmore »for capsid assembly, both as an architectural element of the CA hexamer and pentamer and as a mechanistic element for generating lattice curvature. Here we report biochemical experiments showing that PF-3450074 (PF74), a drug that inhibits HIV-1 infection, as well as host proteins cleavage and polyadenylation specific factor 6 (CPSF6) and nucleoporin 153 kDa (NUP153), bind to the CA hexamer with at least 10-fold higher affinities compared with nonassembled CA or isolated CA domains. The crystal structure of PF74 in complex with the CA hexamer reveals that PF74 binds in a preformed pocket encompassing the NTD–CTD interface, suggesting that the principal inhibitory target of PF74 is the assembled capsid. Likewise, CPSF6 binds in the same pocket. Given that the NTD–CTD interface is a specific molecular signature of assembled hexamers in the capsid, binding of NUP153 at this site suggests that key features of capsid architecture remain intact upon delivery of the preintegration complex to the nucleus.« less

  4. Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

    SciTech Connect (OSTI)

    Bhattacharya, Akash; Alam, Steven L.; Fricke, Thomas; Zadrozny, Kaneil; Sedzicki, Jaroslaw; Taylor, Alexander B.; Demeler, Borries; Pornillos, Owen; Ganser-Pornillos, Barbie K.; Diaz-Griffero, Felipe; Ivanov, Dmitri N.; Yeager, Mark

    2014-12-17

    Upon infection of susceptible cells by HIV-1, the conical capsid formed by ~250 hexamers and 12 pentamers of the CA protein is delivered to the cytoplasm. In this study, the capsid shields the RNA genome and proteins required for reverse transcription. In addition, the surface of the capsid mediates numerous host–virus interactions, which either promote infection or enable viral restriction by innate immune responses. In the intact capsid, there is an intermolecular interface between the N-terminal domain (NTD) of one subunit and the C-terminal domain (CTD) of the adjacent subunit within the same hexameric ring. The NTD–CTD interface is critical for capsid assembly, both as an architectural element of the CA hexamer and pentamer and as a mechanistic element for generating lattice curvature. Here we report biochemical experiments showing that PF-3450074 (PF74), a drug that inhibits HIV-1 infection, as well as host proteins cleavage and polyadenylation specific factor 6 (CPSF6) and nucleoporin 153 kDa (NUP153), bind to the CA hexamer with at least 10-fold higher affinities compared with nonassembled CA or isolated CA domains. The crystal structure of PF74 in complex with the CA hexamer reveals that PF74 binds in a preformed pocket encompassing the NTD–CTD interface, suggesting that the principal inhibitory target of PF74 is the assembled capsid. Likewise, CPSF6 binds in the same pocket. Given that the NTD–CTD interface is a specific molecular signature of assembled hexamers in the capsid, binding of NUP153 at this site suggests that key features of capsid architecture remain intact upon delivery of the preintegration complex to the nucleus.

  5. Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1

    SciTech Connect (OSTI)

    Lee, Ho-Hsien [Arizona State Univ., Tempe, AZ (United States); Cherni, Irene [Arizona State Univ., Tempe, AZ (United States); Yu, Hong Qi [Arizona State Univ., Tempe, AZ (United States); Fromme, Raimund [Arizona State Univ., Tempe, AZ (United States); Doran, Jeffrey D. [Arizona State Univ., Tempe, AZ (United States); Grotjohann, Ingo [Arizona State Univ., Tempe, AZ (United States); Mittman, Michele [Arizona State Univ., Tempe, AZ (United States); Basu, Shibom [Arizona State Univ., Tempe, AZ (United States); Deb, Arpan [Arizona State Univ., Tempe, AZ (United States); Dörner, Katerina [Arizona State Univ., Tempe, AZ (United States); Aquila, Andrew [Center for Free-Electron Laser Science, Hamburg (Germany); Barty, Anton [Center for Free-Electron Laser Science, Hamburg (Germany); Boutet, Sébastien [SLAC National Accelerator Laboratory, Menlo Park, CA (United States); Chapman, Henry N. [Center for Free-Electron Laser Science, Hamburg (Germany); Univ. of Hamburg, Hamburg (Germany); Doak, R. Bruce [Arizona State Univ., Tempe, AZ (United States); Hunter, Mark S. [Arizona State Univ., Tempe, AZ (United States); James, Daniel [Arizona State Univ., Tempe, AZ (United States); Kirian, Richard A. [Center for Free-Electron Laser Science, Hamburg (Germany); Arizona State Univ., Tempe, AZ (United States); Kupitz, Christopher [Arizona State Univ., Tempe, AZ (United States); Lawrence, Robert M. [Arizona State Univ., Tempe, AZ (United States); Liu, Haiguang [Arizona State Univ., Tempe, AZ (United States); Nass, Karol [Center for Free-Electron Laser Science, Hamburg (Germany); Univ. of Hamburg, Hamburg (Germany); Schlichting, Ilme [Max-Planck-Institut fur medizinische, Heidelberg (Germany); Schmidt, Kevin E. [Arizona State Univ., Tempe, AZ (United States); Seibert, M. Marvin [SLAC National Accelerator Lab., Menlo Park, CA (United States); Shoeman, Robert L. [Max-Planck-Institut fur medizinische, Heidelberg (Germany); Spence, John C. H. [Arizona State Univ., Tempe, AZ (United States); Stellato, Francesco [Center for Free-Electron Laser Science, Hamburg (Germany); Weierstall, Uwe [Arizona State Univ., Tempe, AZ (United States); Williams, Garth J. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Yoon, Chunhong [Center for Free-Electron Laser Science, Hamburg (Germany); European XFEL GmbH, Hamburg (Germany); Wang, Dingjie [Arizona State Univ., Tempe, AZ (United States); Zatsepin, Nadia A. [Arizona State Univ., Tempe, AZ (United States); Hogue, Brenda G. [Arizona State Univ., Tempe, AZ (United States); Matoba, Nobuyuki [Arizona State Univ., Tempe, AZ (United States); Fromme, Petra [Arizona State Univ., Tempe, AZ (United States); Mor, Tsafrir S. [Arizona State Univ., Tempe, AZ (United States)

    2014-09-01

    CTB-MPR is a fusion protein between the B subunit of cholera toxin (CTB) and the membrane-proximal region of gp41 (MPR), the transmembrane envelope protein ofHuman immunodeficiency virus 1(HIV-1), and has previously been shown to induce the production of anti-HIV-1 antibodies with antiviral functions. To further improve the design of this candidate vaccine, X-ray crystallography experiments were performed to obtain structural information about this fusion protein. Several variants of CTB-MPR were designed, constructed and recombinantly expressed inEscherichia coli. The first variant contained a flexible GPGP linker between CTB and MPR, and yielded crystals that diffracted to a resolution of 2.3?Å, but only the CTB region was detected in the electron-density map. A second variant, in which the CTB was directly attached to MPR, was shown to destabilize pentamer formation. A third construct containing a polyalanine linker between CTB and MPR proved to stabilize the pentameric form of the protein during purification. The purification procedure was shown to produce a homogeneously pure and monodisperse sample for crystallization. Initial crystallization experiments led to pseudo-crystals which were ordered in only two dimensions and were disordered in the third dimension. Nanocrystals obtained using the same precipitant showed promising X-ray diffraction to 5?Å resolution in femtosecond nanocrystallography experiments at the Linac Coherent Light Source at the SLAC National Accelerator Laboratory. The results demonstrate the utility of femtosecond X-ray crystallography to enable structural analysis based on nano/microcrystals of a protein for which no macroscopic crystals ordered in three dimensions have been observed before.

  6. Element Abundances through the Cosmic Ages

    E-Print Network [OSTI]

    Max Pettini

    2003-03-12

    The horizon for studies of element abundances has expanded dramatically in the last ten years. Once the domain of astronomers concerned chiefly with stars and nearby galaxies, this field has now become a key component of observational cosmology, as technological advances have made it possible to measure the abundances of several chemical elements in a variety of environments at redshifts up to z = 4, when the universe was in its infancy. In this series of lectures I summarise current knowledge on the chemical make-up of distant galaxies observed directly in their starlight, and of interstellar and intergalactic gas seen in absorption against the spectra of bright background sources. The picture which is emerging is one where the universe at z = 3 already included many of the constituents of today's galaxies-even at these early times we see evidence for Population I and II stars, while the `smoking gun' for Population III objects may be hidden in the chemical composition of the lowest density regions of the intergalactic medium, yet to be deciphered.

  7. Early hydrodynamic evolution of a stellar collision

    SciTech Connect (OSTI)

    Kushnir, Doron; Katz, Boaz [Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540 (United States)

    2014-04-20

    The early phase of the hydrodynamic evolution following the collision of two stars is analyzed. Two strong shocks propagate from the contact surface and move toward the center of each star at a velocity that is a small fraction of the velocity of the approaching stars. The shocked region near the contact surface has a planar symmetry and a uniform pressure. The density vanishes at the (Lagrangian) surface of contact, and the speed of sound diverges there. The temperature, however, reaches a finite value, since as the density vanishes, the finite pressure is radiation dominated. For carbon-oxygen white dwarf (CO WD) collisions, this temperature is too low for any appreciable nuclear burning shortly after the collision, which allows for a significant fraction of the mass to be highly compressed to the density required for efficient {sup 56}Ni production in the detonation wave that follows. This property is crucial for the viability of collisions of typical CO WD as progenitors of type Ia supernovae, since otherwise only massive (>0.9 M {sub ?}) CO WDs would have led to such explosions (as required by all other progenitor models). The divergence of the speed of sound limits numerical studies of stellar collisions, as it makes convergence tests exceedingly expensive unless dedicated schemes are used. We provide a new one-dimensional Lagrangian numerical scheme to achieve this. A self-similar planar solution is derived for zero-impact parameter collisions between two identical stars, under some simplifying assumptions (including a power-law density profile), which is the planar version of previous piston problems that were studied in cylindrical and spherical symmetries.

  8. Lunar Science as a Window into the Early Evolution of the Solar System and Conditions on the Early Earth

    E-Print Network [OSTI]

    Crawford, Ian

    Earth In collaboration with the Geological Society of London, and the UK node of the NASA Lunar Science into the Early Evolution of the Solar System and Conditions on the Early Earth. For the last 4.5 billion years the Earth and Moon have essentially comprised a binary planet system which is unique in the inner Solar

  9. Chemical clocks for early-type galaxies

    E-Print Network [OSTI]

    Carretero, C; Beckman, J E

    2007-01-01

    We present a detailed stellar population analysis of 27 massive elliptical galaxies within 4 very rich clusters at redshift z~0.2. We obtained accurate estimates of the mean luminosity-weighted ages and relative abundances of CN, Mg and Fe as functions of the galaxy velocity dispersion, sigma. Our results are compatible with a scenario in which the stellar populations of massive elliptical galaxies, independently of their environment and mass, had formation timescales shorter than ~1 Gyr. This result implies that massive elliptical galaxies have evolved passively since, at least, as long ago as z~2. For a given galaxy mass the duration of star formation is shorter in those galaxies belonging to more dense environments. Finally, we show that the abundance ratios [CN/Fe] and [Mg/Fe] are the key "chemical clocks" to infer the star formation history timescales in ellipticals. In particular, [Mg/Fe] provides an upper limit for those formation timescales, while [CN/Fe] apperars to be the most suitable parameter to ...

  10. Chemical clocks for early-type galaxies

    E-Print Network [OSTI]

    C. Carretero; A. Vazdekis; J. E. Beckman; ;

    2007-03-08

    We present a detailed stellar population analysis of 27 massive elliptical galaxies within 4 very rich clusters at redshift z~0.2. We obtained accurate estimates of the mean luminosity-weighted ages and relative abundances of CN, Mg and Fe as functions of the galaxy velocity dispersion, sigma. Our results are compatible with a scenario in which the stellar populations of massive elliptical galaxies, independently of their environment and mass, had formation timescales shorter than ~1 Gyr. This result implies that massive elliptical galaxies have evolved passively since, at least, as long ago as z~2. For a given galaxy mass the duration of star formation is shorter in those galaxies belonging to more dense environments. Finally, we show that the abundance ratios [CN/Fe] and [Mg/Fe] are the key "chemical clocks" to infer the star formation history timescales in ellipticals. In particular, [Mg/Fe] provides an upper limit for those formation timescales, while [CN/Fe] apperars to be the most suitable parameter to resolve them in elliptical galaxies with sigma<300 km/s.

  11. Molecular Gas and Star Formation in the SAURON Early-type Galaxies

    E-Print Network [OSTI]

    F. Combes; L. M. Young; M. Bureau

    2007-03-21

    We present the results of a survey of CO emission in 43 of the 48 representative E/S0 galaxies observed in the optical with the SAURON integral-field spectrograph. The CO detection rate is 12/43 or 28%. This is lower than previous studies of early-types but can probably be attributed to different sample selection criteria. As expected, earlier type, more luminous and massive galaxies have a relatively lower molecular gas content. We find that CO-rich galaxies tend to have higher H\\beta but lower Fe5015 and Mgb absorption indices than CO-poor galaxies. Those trends appear primarily driven by the age of the stars, an hypothesis supported by the fact that the galaxies with the strongest evidence of star formation are also the most CO-rich. In fact, the early-type galaxies from the current sample appear to extend the well-known correlations between FIR luminosity, dust mass and molecular mass of other galaxy types. The star formation interpretation is also consistent with the SAURON galaxies' radio continuum and FIR flux ratios, and their inferred star formation efficiencies are similar to those in spiral galaxies. It thus appears that we have identified the material fueling (residual) star formation in early-type galaxies, and have demonstrated that it is actively being transformed. Nevertheless, the lack of strong correlations between the CO content and most stellar parameters is compatible with the idea that, in a significant number of sample galaxies, the molecular gas has been accreted from the outside and has properties rather independent from the old, pre-existing stellar component.

  12. Modeling the effects of HIV-1 virions and proteins on Fas-induced apoptosis of infected cells

    E-Print Network [OSTI]

    John Jack; Andrei Paun

    2007-05-14

    We report a first in modeling and simulation of the effects of the HIV proteins on the (caspase dependent) apoptotic pathway in infected cells. This work is novel and is an extension on the recent reports and clarifications on the FAS apoptotic pathway from the literature. We have gathered most of the reaction rates and initial conditions from the literature, the rest of the constants have been computed by fitting our model to the experimental results reported. Using the model obtained we have then run the simulations for the infected memory T cells, called also latent T cells, which, at the moment, represent the major obstacle to finding a cure for HIV. We can now report that the infected latent T cells have an estimated lifetime of about 42 hours from the moment they are re-activated. As far as we know this is the first result of this type obtained for the infected memory T cells.

  13. Aging generates regular motions in weakly chaotic systems

    E-Print Network [OSTI]

    Takuma Akimoto; Eli Barkai

    2012-09-27

    Using intermittent maps with infinite invariant measures, we investigate the universality of time-averaged observables under aging conditions. According to Aaronson-Darling-Kac theorem, in non-aged dynamical systems with infinite invariant measures, the distribution of the normalized time averages of integrable functions converge to the Mittag-Leffler distribution. This well known theorem holds when the start of observations coincides with the start of the dynamical processes. Introducing a concept of the aging limit where the aging time $t_a$ and the total measurement time $t$ goes to infinity while the aging ratio $t_a/t$ is a constant, we obtain a novel distributional limit theorem of time-averaged observables integrable with respect to the infinite invariant density. Applying the theorem to the Lyapunov exponent in intermittent maps, we find that regular motions and a weakly chaotic behavior coexist in the aging limit. This mixed type of dynamics is controlled by the aging ratio and hence is very different from the usual scenario of regular and chaotic motions in Hamiltonian systems. The probability of finding regular motions in non-aged processes is zero, while in the aging regime it is finite and it increases when system ages.

  14. LIGA microsystems aging : evaluation and mitigation.

    SciTech Connect (OSTI)

    Cadden, Charles H.; Yang, Nancy Y. C.; San Marchi, Christopher W.

    2003-12-01

    The deployment of LIGA structures in DP applications requires a thorough understanding of potential long term physical and chemical changes that may occur during service. While these components are generally fabricated from simple metallic systems such as copper, nickel and nickel alloys, the electroplating process used to form them creates microstructural features which differ from those found in conventional (e.g. ingot metallurgy) processing of such materials. Physical changes in non-equilibrium microstructures may occur due to long term exposure to temperatures sufficient to permit atomic and vacancy mobility. Chemical changes, particularly at the surfaces of LIGA parts, may occur in the presence of gaseous chemical species (e.g. water vapor, HE off-gassing compounds) and contact with other metallic structures. In this study, we have characterized the baseline microstructure of several nickel-based materials that are used to fabricate LIGA structures. Solute content and distribution was found to have a major effect on the electroplated microstructures. Microstructural features were correlated to measurements of hardness and tensile strength. Dormancy testing was conducted on one of the baseline compositions, nickel-sulfamate. Groups of specimens were exposed to controlled thermal cycles; subsequent examinations compared properties of 'aged' specimens to the baseline conditions. Results of our testing indicate that exposure to ambient temperatures (-54 C to 71 C) do not result in microstructural changes that might be expected to significantly effect mechanical performance. Additionally, no localized changes in surface appearance were found as a result of contact between electroplated parts.

  15. Early Market TRL/MRL Analysis

    SciTech Connect (OSTI)

    Ronnebro, Ewa; Stetson, Ned

    2013-12-01

    he focus of this report is TRL/MRL analysis of hydrogen storage; it documents the methodology and results of an effort to identify hydrogen storage technologies’ technical and manufacturing readiness for early market motive and non-motive applications and to provide a path forward toward commercialization. Motive applications include materials handling equipment (MHE) and ground support equipment (GSE), such as forklifts, tow tractors, and specialty vehicles such as golf carts, lawn mowers and wheel chairs. Non-motive applications are portable, stationary or auxiliary power units (APUs) and include portable laptops, backup power, remote sensor power, and auxiliary power for recreational vehicles, hotels, hospitals, etc. Hydrogen storage technologies assessed include metal hydrides, chemical hydrides, sorbents, gaseous storage, and liquid storage. The assessments are based on a combination of Technology Readiness Level (TRL) and Manufacturing Readiness Level (MRL) designations that enable evaluation of hydrogen storage technologies at varying levels of development. The manufacturing status could be established from eight risk elements: Technical Maturity, Design, Materials, Cost & Funding, Process Capability, Personnel, Facilities and Manufacturing Planning. This approach provides a logical methodology and roadmap to enable the identification of hydrogen storage technologies, their advantages/disadvantages, gaps and R&D needs on an unbiased and transparent scale that is easily communicated to interagency partners. This technology readiness assessment (TRA) report documents the process used to conduct the TRA/MRA (technology and manufacturing readiness assessment), reports the TRL and MRL for each assessed technology and provides recommendations based on the findings. To investigate the state of the art and needs to mature the technologies, PNNL prepared a questionnaire to assign TRL and MRL for each hydrogen storage technology. The questionnaire was sent to identified hydrogen storage technology developers and manufacturers who were asked to perform a self-assessment. We included both domestic and international organizations including U.S. national laboratories, U.S. companies, European companies and Japanese companies. PNNL collected the data and performed an analysis to deduce the level of maturity and to provide program recommendations.

  16. Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Moody, M.  Anthony; Gao, Feng; Gurley, Thaddeus  C.; Amos, Joshua  D.; Kumar, Amit; Hora, Bhavna; Marshall, Dawn  J.; Whitesides, John  F.; Xia, Shi-Mao; Parks, Robert; et al

    2015-09-09

    The third variable (V3) loop and the CD4 binding site (CD4bs) of the viral envelope are frequently targeted by neutralizing antibodies (nAbs) in HIV-1-infected individuals. In chronic infection, virus escape mutants repopulate the plasma and V3 and CD4bs nAbs emerge that can neutralize heterologous tier 1 easy-to-neutralize, but not tier 2 difficult-to-neutralize HIV-1 isolates. However, neutralization sensitivity of autologous plasma viruses to this type of nAb response has not been studied. We describe the development and evolution in vivo of antibodies distinguished by their target specificity for V3and CD4bs epitopes on autologous tier 2 viruses but not on heterologous tiermore »2 viruses. A surprisingly high fraction of autologous circulating viruses was sensitive to these antibodies. These findings demonstrate a role for V3 and CD4bs antibodies in constraining the native envelope trimer in vivo to a neutralization-resistant phenotype, explaining why HIV-1 transmission generally occurs by tier 2 neutralization-resistant viruses.« less

  17. Technology and social process : oscillations in Iron Age copper production and power in Southern Jordan

    E-Print Network [OSTI]

    Ben-Yosef, Erez

    2010-01-01

    Valley (Tell Hammeh) and iron mining at Mugharat al-Wardahpress. Patterns of Iron Age Mining and Iron Age Settlementresearch concerning Iron Age mining and metallurgy in the

  18. Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart

    E-Print Network [OSTI]

    2015-01-01

    of myo- fibrillar perturbation and aging on soft, bilayeredthat mimic the effects of aging. Proc. Natl. Acad. Sci.understanding cardiac aging and for selecting therapeutic

  19. LEAVING THE DARK AGES WITH AMIGA

    SciTech Connect (OSTI)

    Manrique, Alberto; Salvador-Solé, Eduard; Juan, Enric; Rozas, José María; Sagristà, Antoni; Casteels, Kevin [Institut de Ciències del Cosmos, Universitat de Barcelona, UB-IEEC, Martí i Franquès 1, E-08028 Barcelona (Spain); Hatziminaoglou, Evanthia [European Southern Observatory, Karl-Schwarzschild-Strasse 2, D-85748 Garching bei Mnchen (Germany); Bruzual, Gustavo [Centro de Radioastronomía y Astrofísica, UNAM, Campus Morella (Mexico); Magris, Gladis, E-mail: a.manrique@ub.edu [Centro de Investigaciones de Astronomía, Apartado Postal 264, Mérida 5101-A (Venezuela, Bolivarian Republic of)

    2015-01-01

    We present an Analytic Model of Intergalactic-medium and GAlaxy (AMIGA) evolution since the dark ages. AMIGA is in the spirit of the popular semi-analytic models of galaxy formation, although it does not use halo merger trees but interpolates halo properties in grids that are progressively built. This strategy is less memory-demanding and allows one to start modeling at sufficiently high redshifts and low halo masses to have trivial boundary conditions. The number of free parameters is minimized by making a causal connection between physical processes usually treated as independent of each other, which leads to more reliable predictions. However, the strongest points of AMIGA are the following: (1) the inclusion of molecular cooling and metal-poor, population III (Pop III) stars with the most dramatic feedback and (2) accurate follow up of the temperature and volume filling factor of neutral, singly ionized, and doubly ionized regions, taking into account the distinct halo mass functions in those environments. We find the following general results. Massive Pop III stars determine the intergalactic medium metallicity and temperature, and the growth of spheroids and disks is self-regulated by that of massive black holes (MBHs) developed from the remnants of those stars. However, the properties of normal galaxies and active galactic nuclei appear to be quite insensitive to Pop III star properties due to the much higher yield of ordinary stars compared to Pop III stars and the dramatic growth of MBHs when normal galaxies begin to develop, which cause the memory loss of the initial conditions.

  20. The role of phase instabilities in the early material response...

    Office of Scientific and Technical Information (OSTI)

    The role of phase instabilities in the early material response during laser-induced breakdown in bulk fused silica Citation Details In-Document Search Title: The role of phase...