Sample records for hiv early aging

  1. National Institute on Aging HIV, AIDS, and

    E-Print Network [OSTI]

    Levin, Judith G.

    -term memory loss. You can now also test your blood at home. The "Home Access Express HIV-1 Test System, a close family friend she had known for a long time, was starting to stay overnight more and more often HIV and AIDS. You may have thought that these diseases weren't your problem and that only younger

  2. Protein Structure Could Lead to Better Treatments for HIV, Early...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    early-aging diseases and redesign AIDS medications to avoid side effects such as diabetes. The research was carried out at the Southeastern Regional Collaborative Access Team...

  3. Additive effects of aging and HIV infection on category verbal fluency : an analysis of component processes

    E-Print Network [OSTI]

    Iudicello, Jennifer E.

    2011-01-01T23:59:59.000Z

    R. K. , & Grant, I. (2006). Additive deleterious effects ofGrob, C. S. (2005). Additive effects of HIV and chronicGroup. (2011, February). Additive effects of aging and HIV

  4. Antibody Evolution Could Guide HIV Vaccine Development | Advanced...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lead to Better Treatments for HIV, Early Aging The Superpower behind Iron Oxyfluoride Battery Electrodes Watching a Protein as it Functions Science Highlights Archives: 2014...

  5. EARLY-AGE CRACKING REVIEW: MECHANISMS, MATERIAL PROPERTIES,

    E-Print Network [OSTI]

    Bentz, Dale P.

    ://cementbarriers.org/ and Savannah River National Laboratory website: http://srnl.doe.gov #12;Early-Age Cracking Review: Mechanisms Commission (NRC), the National Institute of Standards and Technology (NIST), the Savannah River National of work performed in part under that contract. This report was prepared in support of the Savannah River

  6. Bronze metallurgy in Iron Age central Europe : a metallurgical study of Early Iron Age bronzes from Sti?na, Slovenia.

    E-Print Network [OSTI]

    Cooney, Elizabeth Myers

    2007-01-01T23:59:59.000Z

    The Early Iron Age (750-450 BCE) marks a time in the European Alpine Region in which cultural ideologies surrounding bronze objects and bronze production were changing. Iron was becoming the preferred material from which ...

  7. The Early Formation, Evolution and Age of the Neutron-Capture Elements in the Early Galaxy

    E-Print Network [OSTI]

    J. J. Cowan; C. Sneden; J. W. Truran

    2001-03-14T23:59:59.000Z

    Abundance observations indicate the presence of rapid-neutron capture (i.e., r-process) elements in old Galactic halo and globular cluster stars. These observations demonstrate that the earliest generations of stars in the Galaxy, responsible for neutron-capture synthesis and the progenitors of the halo stars, were rapidly evolving. Abundance comparisons among several halo stars show that the heaviest neutron-capture elements (including Ba and heavier) are consistent with a scaled solar system r-process abundance distribution, while the lighter such elements do not conform to the solar pattern. These comparisons suggest two r-process sites or at least two different sets of astrophysical conditions. The large star-to-star scatter observed in the neutron-capture/iron ratios at low metallicities -- which disappears with increasing [Fe/H] -- suggests an early, chemically unmixed and inhomogeneous Galaxy. The stellar abundances indicate a change from the r-process to the slow neutron capture (i.e., s-) process at higher metallicities in the Galaxy. The detection of thorium in halo and globular cluster stars offers a promising, independent age-dating technique that can put lower limits on the age of the Galaxy.

  8. Guang Ye, Characterization of cement paste at early age, 1 of 11 Fax: +31 15 2785895

    E-Print Network [OSTI]

    Guang Ye, Characterization of cement paste at early age, 1 of 11 Fax: +31 15 2785895 E-mail: ye.guang@ct.tudelft.nl A MICROMECHANIC MODEL FOR CHARACTERIZATION OF CEMENT PASTE AT EARLY AGE VALIDATED WITH EXPERIMENTS Guang Ye Delft of a cement-based material, i.e. the stiffness of cement paste, is the result of the continuous change

  9. Timing of the Early Triassic carbon cycle perturbations inferred from new UPb ages and ammonoid biochronozones

    E-Print Network [OSTI]

    Gilli, Adrian

    reserved. Keywords: carbon isotope; U­Pb age; time scale; ammonoid; Early Triassic; South China EarthTiming of the Early Triassic carbon cycle perturbations inferred from new U­Pb ages and ammonoid and Mineral Resources, Jiangzheng Road 1, 530023 Nanning, China Received 13 October 2006; received in revised

  10. Feeding the periphery : modeling early Bronze Age economies and the cultural landscape of the Faynan District, Southern Jordan

    E-Print Network [OSTI]

    Muniz, Adolfo A.

    2007-01-01T23:59:59.000Z

    Archaeology and Early Metallurgy at Khirbet Hamra Ifdan andSabanne 1989 Copper Metallurgy, Trade and the Urbanization2002 Early Bronze Age Metallurgy: A Newly Discovered Copper

  11. An age-structured model for the coupled dynamics of HIV and HSV-2

    E-Print Network [OSTI]

    2014-12-24T23:59:59.000Z

    The results are discussed in the last section. 2010 Mathematics Subject Classification. Primary: 92B05, 92D30; Secondary: 92D25. Key words and phrases. HIV ...

  12. Modeling the Effect of Curing on Early Age Distress Potential of Concrete Pavement

    E-Print Network [OSTI]

    Bari, Muhammad Ehsanul

    2014-04-11T23:59:59.000Z

    , such as the variation of temperature and relative humidity, during the early age after concrete placement. Experimental test results were obtained and mathematical models were developed for this research. Modeling the effect of curing process in response...

  13. Improved age control on early Homo fossils from the upper Burgi Member at Koobi Fora, Kenya

    E-Print Network [OSTI]

    Utrecht, Universiteit

    Improved age control on early Homo fossils from the upper Burgi Member at Koobi Fora, Kenya in Areas 105 and 131 on the Karari Ridge in the eastern Turkana Basin (Kenya). We identify the base

  14. Improved age control on early Homo fossils from the upper Burgi Member at Koobi Fora, Kenya

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Improved age control on early Homo fossils from the upper Burgi Member at Koobi Fora, Kenya in Areas 105 and 131 on the Karari Ridge in the eastern Turkana Basin (Kenya). We identify the base

  15. Tackling Dyslexia at an Early Age esearchers at HMS and Boston Children's

    E-Print Network [OSTI]

    Corey, David P.

    Tackling Dyslexia at an Early Age R esearchers at HMS and Boston Children's Hospital who have been studying dyslexia in children have identified differences in the brain activity of at-risk children that very young children at risk for dyslexia could take part in early intervention programs that may help

  16. HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of apobec

    SciTech Connect (OSTI)

    Korber, Bette [Los Alamos National Laboratory; Bhattacharya, Tanmoy [Los Alamos National Laboratory; Giorgi, Elena [Los Alamos National Laboratory; Gaschen, B [Los Alamos National Laboratory; Daniels, M [Los Alamos National Laboratory

    2009-01-01T23:59:59.000Z

    The pattern of viral diversification in newly infected individuals provides information about the host environment and immune responses typically experienced by the newly transmitted virus. For example, sites that tend to evolve rapidly across multiple early-infection patients could be involved in enabling escape from common early immune responses, represent adaptation for rapid growth in a newly infected host, or reversion from less fit forms of the virus that were selected for immune escape in previous hosts. Here we investigated the diversification of HIV -I env coding sequences in 81 very early B SUbtype infections previously shown to have resulted from transmission or expansion of single viruses (n=78) or two closely related viruses (n=3). In these cases the sequence of the infecting virus can be estimated accurately, enabling inference of both the direction of substitutions as well as distinction between insertion and deletion events. By integrating information across multiple acutely infected hosts, we find evidence of adaptive evolution of HIV-1 envand identified a subset of codon sites that diversified more rapidly than can be explained by a model of neutral evolution. Of 24 such rapidly diversifying sites, 14 were either (i) clustered and embedded in CTL epitopes that were verified experimentally or predicted based on the individual's HLA or (ii) in a nucleotide context indicative of APOBEC mediated G-to-A substitutions, despite having excluded heavily hypermutated sequences prior to the analysis. In several cases, a rapidly evolving site was both embedded in an APOBEC motif and in a CTL epitope, suggesting that APOBEC may facilitate early immune escape. Ten rapidly diversifying sites could not be explained by CTL escape or APOBEC hypermutation, including the most frequently mutated site, in the fusion peptide of gp4l. We also examined the distribution, extent, and sequence context of insertions and deletions and provide evidence that the length variation seen in hypervariable loop regions of the envelope glycoprotein is a consequence of selection and not mutational hotspots. These results provide a detailed view of the process of diversification of HIV-1 following transmission.

  17. Impact of hydroxypropylguars on the early age hydration1 of portland cement2

    E-Print Network [OSTI]

    Impact of hydroxypropylguars on the early age hydration1 of portland cement2 3 4 Thomas Poinot: govin@emse.fr12 hal-00758284,version1-29Nov2012 Author manuscript, published in "Cement and Concrete on cement hydration was investigated in order to improve17 understanding on the delayed effect induced

  18. Impact of hydroxypropylguars on the early age hydration1 of portland cement2

    E-Print Network [OSTI]

    Boyer, Edmond

    Impact of hydroxypropylguars on the early age hydration1 of portland cement2 3 4 Thomas Poinot: govin@emse.fr12 hal-00758284,version2-15Feb2013 Author manuscript, published in "Cement and Concrete on cement hydration was investigated in order to improve17 understanding on the delayed effect induced

  19. Keynote Paper, Shah, Page 1/13 HEALTH MONITORING OF EARLY AGE CONCRETE

    E-Print Network [OSTI]

    relationship to the actual concrete in the structure. This calls for nondestructive test methods that offer potential for the application of nondestructive testing of concrete under field conditions. The resultsKeynote Paper, Shah, Page 1/13 HEALTH MONITORING OF EARLY AGE CONCRETE Thomas Voigt, Zhihui Sun

  20. Early Jurassic shale chemostratigraphy and UPb ages from the Neuqun Basin (Argentina): Implications for the Toarcian Oceanic Anoxic Event

    E-Print Network [OSTI]

    Svensen, Henrik

    Early Jurassic shale chemostratigraphy and U­Pb ages from the Neuquén Basin (Argentina shale section in the Neuquén Basin, Argentina, are presented in order to better constrain the triggering. Chemostratigraphy from a 65 m thick shale-dominated marine section of Late Pliensbachian to Early Toarcian age shows

  1. The Main Mantle Thrust (MMT) is the regional contact between collider India and the overthrust Kohistan-Ladakh series in the Pakistan Himalaya. Early Himalayan-age

    E-Print Network [OSTI]

    Kidd, William S. F.

    and the overthrust Kohistan-Ladakh series in the Pakistan Himalaya. Early Himalayan-age thrusting and some later (~20

  2. Prediction of early-age cracking of UHPC materials and structures : a thremo-chemo-mechanics approach

    E-Print Network [OSTI]

    Shim, JongMin, 1975-

    2005-01-01T23:59:59.000Z

    Ultra-High Performance Concrete [UHPC] has remarkable performance in mechanical properties, ductility, economical benefit, etc., but early-age cracking of UHPC can become an issue during the manufacturing process due to ...

  3. An early Miocene age for a high-temperature event in gneisses from Zabargad Island (Red Sea, Egypt): mantle diapirism?

    E-Print Network [OSTI]

    Demouchy, Sylvie

    An early Miocene age for a high-temperature event in gneisses from Zabargad Island (Red Sea, Egypt outcropping on Zabargad Island (Red Sea, Egypt). This island, though of limited size (& 4 km2 ), has an almost

  4. Atomic structure of Cu-10. 9 at % Be alloys in the early stages of aging

    SciTech Connect (OSTI)

    Koo, Y.M.

    1987-01-01T23:59:59.000Z

    Diffuse x-ray scattering was employed to investigate the local atomic structure and static strains in a single crystal of a Cu-10.9 at. % Be alloy in the early stages of aging. In addition to these experiments, neutron elastic and inelastic scattering were obtained to investigate the phonon properties in the as-quenched state of this alloy. In the as-quenched state, there is a nearly regular array of small ellipsoidal Be clusters aligned along <100> directions (This produces the tweed contrast seen in TEM). The density of these clusters is 7.5 x 10/sup 26//m/sup 3/. The diffuse streaks seen in electron diffraction patterns are due largely to thermal diffuse scattering. Phonon-dispersion curves show no large differences from those of pure copper, except at (xi xi xi)/sub T/ zone boundary, where there is softening. This difference may be due to a Kohn anomaly. The elastic anisotropy of this alloy increases considerably with alloying, which probably leads to the plate-like GP zone morphology in subsequent aging treatments. The structure of the GP zones is a mixture of Be-rich single- and multi-layered zones. As aging proceeds, the zones grow in thickness.

  5. Living and Dying Abroad: Aspects of Egyptian Cultural Identity in Late Bronze Age and Early Iron Age Canaan

    E-Print Network [OSTI]

    Pierce, Krystal Victoria Lords

    2013-01-01T23:59:59.000Z

    74 lamps, one biconical strainer-spouted jug, one pyxis, 25Age pottery like the biconical strainer- spouted jug and theand bronze juglet, strainer, lamp, and deep hemispherical

  6. Influence of Cement Particle-Size Distribution on Early Age Autogenous Strains and Stresses in Cement-Based Materials

    E-Print Network [OSTI]

    Bentz, Dale P.

    Influence of Cement Particle-Size Distribution on Early Age Autogenous Strains and Stresses in Cement-Based Materials Dale P. Bentz* Building and Fire Research Laboratory, National Institute-Jochen Haecker* Wilhelm Dyckerhoff Institut, 65203 Wiesbaden, Germany The influence of cement particle

  7. In-situ early-age hydration study of sulfobelite cements by synchrotron powder diffraction

    SciTech Connect (OSTI)

    Álvarez-Pinazo, G.; Cuesta, A.; García-Maté, M.; Santacruz, I.; Losilla, E.R. [Departamento de Química Inorgánica, Universidad de Málaga, Campus Teatinos S/N., 29071 Málaga (Spain)] [Departamento de Química Inorgánica, Universidad de Málaga, Campus Teatinos S/N., 29071 Málaga (Spain); Sanfélix, S.G. [Unidad Técnica de Investigación de Materiales, AIDICO, Avda. Benjamín Franklin, 17 Paterna, Valencia (Spain)] [Unidad Técnica de Investigación de Materiales, AIDICO, Avda. Benjamín Franklin, 17 Paterna, Valencia (Spain); Fauth, F. [CELLS-Alba synchrotron, Carretera BP 1413, Km. 3.3, E-08290 Cerdanyola, Barcelona (Spain)] [CELLS-Alba synchrotron, Carretera BP 1413, Km. 3.3, E-08290 Cerdanyola, Barcelona (Spain); Aranda, M.A.G. [Departamento de Química Inorgánica, Universidad de Málaga, Campus Teatinos S/N., 29071 Málaga (Spain) [Departamento de Química Inorgánica, Universidad de Málaga, Campus Teatinos S/N., 29071 Málaga (Spain); CELLS-Alba synchrotron, Carretera BP 1413, Km. 3.3, E-08290 Cerdanyola, Barcelona (Spain); De la Torre, A.G., E-mail: mgd@uma.es [Departamento de Química Inorgánica, Universidad de Málaga, Campus Teatinos S/N., 29071 Málaga (Spain)

    2014-02-15T23:59:59.000Z

    Eco-friendly belite calcium sulfoaluminate (BCSA) cement hydration behavior is not yet well understood. Here, we report an in-situ synchrotron X-ray powder diffraction study for the first hours of hydration of BCSA cements. Rietveld quantitative phase analysis has been used to establish the degree of reaction (?). The hydration of a mixture of ye'elimite and gypsum revealed that ettringite formation (? ? 70% at 50 h) is limited by ye'elimite dissolution. Two laboratory-prepared BCSA cements were also studied: non-active-BCSA and active-BCSA cements, with ?- and ??{sub H}-belite as main phases, respectively. Ye'elimite, in the non-active-BCSA system, dissolves at higher pace (? ? 25% at 1 h) than in the active-BCSA one (? ? 10% at 1 h), with differences in the crystallization of ettringite (? ? 30% and ? ? 5%, respectively). This behavior has strongly affected subsequent belite and ferrite reactivities, yielding stratlingite and other layered phases in non-active-BCSA. The dissolution and crystallization processes are reported and discussed in detail. -- Highlights: •Belite calcium sulfoaluminate cements early hydration mechanism has been determined. •Belite hydration strongly depends on availability of aluminum hydroxide. •Orthorhombic ye’elimite dissolved at a higher pace than cubic one. •Ye’elimite larger reaction degree yields stratlingite formation by belite reaction. •Rietveld method quantified gypsum, anhydrite and bassanite dissolution rates.

  8. Stellar age versus mass of early-type galaxies in the Virgo Cluster

    E-Print Network [OSTI]

    Thorsten Lisker; Zhanwen Han

    2008-03-17T23:59:59.000Z

    The flux excess of elliptical galaxies in the far-ultraviolet can be reproduced by population synthesis models when accounting for the population of old hot helium-burning subdwarf stars. This has been achieved by Han and coworkers through a quantitative model of binary stellar evolution. Here, we compare the resulting evolutionary population synthesis model to the GALEX far-near ultraviolet colors (FUV-NUV) of Virgo cluster early-type galaxies that were published by Boselli and coworkers. FUV-NUV is reddest at about the dividing luminosity of dwarf and giant galaxies, and becomes increasingly blue for both brighter and fainter luminosities. This behavior can be easily explained by the binary model with a continuous sequence of longer duration and later truncation of star formation at lower galaxy masses. Thus, in contrast to previous conclusions, the GALEX data do not require a dichotomy between the stellar population properties of dwarfs and giants. Their apparently opposite behavior in FUV-NUV occurs naturally when the formation of hot subdwarfs through binary evolution is taken into account.

  9. ASCE Journal of Materials in Civil Engineering, 20 (7), 502-508, 2008. Early-Age Properties of Cement-Based Materials: I. Influence of Cement Fineness

    E-Print Network [OSTI]

    Bentz, Dale P.

    of Cement-Based Materials: I. Influence of Cement Fineness Dale P. Bentz1* , Gaurav Sant1 , and Jason Weiss1 Abstract The influence of cement fineness on early-age properties of cement-based materials is investigated deformation. Measurements of these properties for two cements of widely different fineness are supplemented

  10. Musicians' Enhanced Neural Differentiation of Speech Sounds Arises Early in Life: Developmental Evidence from Ages 3 to 30

    E-Print Network [OSTI]

    Kraus, Nina

    Musicians' Enhanced Neural Differentiation of Speech Sounds Arises Early in Life: Developmental; this training may generalize to speech processing given that adult musicians have enhanced neural-Muniz et al. 2012). We recently reported enhanced subcortical distinction of similar speech sounds (e

  11. The significance of Rb-Sr glauconite ages, Bonneterre Formation, Missouri; Late Devonian-Early Mississippian brine migration in the midcontinent

    SciTech Connect (OSTI)

    Stein, H.J. (Geological Survey, Denver, CO (USA)); Kish, S.A. (Florida State Univ., Tallahassee (USA))

    1991-05-01T23:59:59.000Z

    Rb-Sr mean model ages of 370 {plus minus} 10 Ma for glauconites from the Cambrian lower Bonneterre Formation in southern and central Missouri are in excellent agreement with a Rb-Sr isochron age of 359 {plus minus} 22 Ma for glauconites from the Magmont mine (Viburnum Trend) in the southeast Missouri lead district. The lower Bonneterre and Magmont mines ages probably reflect isotopic resetting, most likely associated with dolomitization and/or Mississippi Valley-type ore formation in the southeast Missouri lead district. The temporal relation between widespread dolomitization and ore formation in Missouri is unclear, but mounting evidence for two Devonian disturbances permits the following interpretation: (1) a Devonian timing (380-400 Ma) for widespread dolomitization, and (2) a Late Devonian-Early Mississippian timing (360-370 Ma) for ore formation in southeast Missouri. Late Devonian-Early Mississippian fluids associated with the earliest stages of collisional tectonics and metamorphism to the south and southeast may have been important in the formation of southeast Missouri ore deposits. These tectonically driven waters may themselves have been the Mississippi Valley-type ore fluids, entering Missouri by way of the Black Warrior basin and Reelfoot rift and/or the Arkoma basin. Alternatively, the movement of orogenic fluids hundreds of kilometers distant may have initiated and distally influenced the migration of more locally derived Mississippi Valley-type ore fluids. Broad regions of Missouri and adjacent areas experienced heating and crustal flexing in the Late Devonian, and consequently, preservation of elevated temperatures in Mississippi Valley-type fluids as they move great lateral distances may not be necessary for ore formation in southeast Missouri.

  12. aging aircraft nondestructive: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    at Early Ages An Experimental and Numerical Analysis by Dr for Nondestructive Testing of Cement-Based Materials at Early Ages - An Experi- mental and Numerical Analysis...

  13. Design and expression of a short peptide as an HIV detection probe

    SciTech Connect (OSTI)

    Lines, Jamie A.; Yu, Zhiqiang; Dedkova, Larisa M.; Chen, Shengxi, E-mail: shengxi.chen.1@asu.edu

    2014-01-03T23:59:59.000Z

    Highlights: •We designed a short fusion peptide (FP-50) for in vivo expression. •This peptide is a very promising component for detection of gp120 protein. •The detectable level is about 20–200 times lower than previously published methods. •It is a novel probe to detect HIV-1 gp120 during early stages of HIV infection. -- Abstract: To explore a low-cost novel probe for HIV detection, we designed and prepared a 50-amino acid-length short fusion peptide (FP-50) via Escherichia coli in vivo expression. It was employed as a novel probe to detect HIV-1 gp120 protein. The detectable level of gp120 protein using the FP-50 peptide was approximately 20–200 times lower than previously published methods that used a pair of monoclonal antibodies. Thus, this short peptide is a very promising component for detection of gp120 protein during early stages of HIV infection.

  14. The Evolution of the M_BH-sigma relation Inferred from the Age Distribution of Local Early-Type Galaxies and AGN Evolution

    E-Print Network [OSTI]

    Shankar, Francesco; Haiman, Zoltan

    2008-01-01T23:59:59.000Z

    We utilize the local velocity dispersion function (VDF) of spheroids, together with their inferred age--distributions, to predict the VDF at higher redshifts (01.3 excluded at the 99% confidence level. A direct match between the characteristic BH mass in the VDF--based and quasar LF--based BH mass functions also yields a mean Eddington ratio of lambda ~ 0.5-1 that is roughly constant within 00.23 for alpha>1.5. abridged

  15. Early Brain Response to Low-Dose Radiation Exposure Involves Molecular Networks and Pathways Associated with Cognitive Functions, Advanced Aging and Alzheimer's Disease

    SciTech Connect (OSTI)

    Lowe, Xiu R; Bhattacharya, Sanchita; Marchetti, Francesco; Wyrobek, Andrew J.

    2008-06-06T23:59:59.000Z

    Understanding the cognitive and behavioral consequences of brain exposures to low-dose ionizing radiation has broad relevance for health risks from medical radiation diagnostic procedures, radiotherapy, environmental nuclear contamination, as well as earth orbit and space missions. Analyses of transcriptome profiles of murine brain tissue after whole-body radiation showed that low-dose exposures (10 cGy) induced genes not affected by high dose (2 Gy), and low-dose genes were associated with unique pathways and functions. The low-dose response had two major components: pathways that are consistently seen across tissues, and pathways that were brain tissue specific. Low-dose genes clustered into a saturated network (p < 10{sup -53}) containing mostly down-regulated genes involving ion channels, long-term potentiation and depression, vascular damage, etc. We identified 9 neural signaling pathways that showed a high degree of concordance in their transcriptional response in mouse brain tissue after low-dose radiation, in the aging human brain (unirradiated), and in brain tissue from patients with Alzheimer's disease. Mice exposed to high-dose radiation did not show these effects and associations. Our findings indicate that the molecular response of the mouse brain within a few hours after low-dose irradiation involves the down-regulation of neural pathways associated with cognitive dysfunctions that are also down regulated in normal human aging and Alzheimer's disease.

  16. Rb-Sr-analyses of apollo 16 melt rocks and a new age estimate for the imbrium basin: lunar basin chronology and the early heavy bombardment of the moon

    SciTech Connect (OSTI)

    Deutsch, A.; Stoeffler, D.

    1987-07-01T23:59:59.000Z

    Rb-Sr-model ages on 7 impact glass-bombs and internal Rb-Sr isochrons for two crystalline impact melt rocks from the Apollo 16 collection have been determined. The post-Cayley glass-bombs with model ages between 4.75 +- 0.45 AE and 3.97 +- 0.08 AE can be classified according to their calculated single stage (/sup 87/Rb/sup 86/Sr)/sub I/-ratios: 67728, 67946, and 67627.8 point to a KREEP-free precursor terrain - the Descartes highlands; whereas 63566, 67567, 67627.10 and 67629 are derived from the more heterogeneous Cayley plains. The very feldspar-rich impact melt rock 65795, which is compositionally similar to the group of feldspathic microporphyritic melt breccias (FM-suite), yields a crystallization age of 3.81 +- 0.04 AE (2sigma; lambda/sup 87/Rb = 1.42/sup -11/ yr/sup -1/) and I/sub Sr/ of .69929 +- 3. The authors suggest that the Imbrium basin and the related Fra Mauro and Cayley formations were formed 3.77 +- 0.02 AE ago and could be even as young as 3.75 AE. As a consequence, they adopt 3.92 +- 0.03 AE, 3.87 +- 0.03 AE, and 3.84 +- 0.04 AE as ages for the Nectaris, Serenitatis, and Crisium basins, respectively, in agreement with the relative crater densities measured on the ejecta blankets of these basins. The proposed age sequence leads to an average formation interval for the observed 12-13 Nectarian basins of 7 to 14 m.y. leaving approx. 30 pre-Nectarian basins of unknown age. These facts suggest that there is no late terminal lunar cataclysm in the sense of a culmination of the lunar impact rate at approx. 3.8 AE ago. Rather, the observations are compatible with a steeply and steadily decreasing flux of impactors in the sense of an early heavy bombardment which started at the time of the moon's accretion and terminated around 3.75 AE ago.

  17. american children ages: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    july 2004 Age-Specific Demography in Plantago: Uncovering Roach,. Deborah 17 Tackling Dyslexia at an Early Age esearchers at HMS and Boston Children's Biology and Medicine Websites...

  18. Integrated Geochronologic, Geochemical, and Sedimentological Investigation of Proterozoic-Early Paleozoic Strata: From Northern India to Global Perspectives

    E-Print Network [OSTI]

    McKenzie, Neil Ryan

    2012-01-01T23:59:59.000Z

    Supergroup,  India:  age,  diagenesis,  correlations  and  during  very  early  diagenesis  (Bengtson   et  al. ,  

  19. MATHEMATICAL ANALYSIS OF AGE-STRUCTURED HIV-1 ...

    E-Print Network [OSTI]

    SIAM (#1) 1035 2001 Apr 10 12:32:38

    2007-08-22T23:59:59.000Z

    namics of the target cells and infected cells, viral production and clearance, and the effects of antiretroviral drugs treatment. Perelson et al. [44] and Ho et al.

  20. Relative Ages of Globular Clusters

    E-Print Network [OSTI]

    Thomas H. Puzia

    2002-10-18T23:59:59.000Z

    Ages of extragalactic globular clusters can provide valuable insights into the formation and evolution of galaxies. In this contribution the photometric methods of age dating old globular cluster systems are summarised. The spectroscopic approach is reviewed with an emphasis of the right choice of age diagnostics. We present a new method of quantifying the relatively best age-sensitive spectroscopic index given the quality of a data set and a certain theoretical stellar synthesis model. The relatively best diagnostic plot is constructed from the set of Lick indices and used to age date globular clusters in several early-type galaxies which are part of a large spectroscopic survey of extragalactic globular cluster systems. We find that, independently of host galaxy, metal-poor ([Fe/H] 8 Gyr) and coeval. Metal-rich clusters show a wide range of ages from ~15 down to a few Gyr.

  1. age mexican children: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    surface area, and thickness measures were obtained. Anxiety symptoms were 18 Tackling Dyslexia at an Early Age esearchers at HMS and Boston Children's Biology and Medicine Websites...

  2. age children group: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    surface area, and thickness measures were obtained. Anxiety symptoms were 22 Tackling Dyslexia at an Early Age esearchers at HMS and Boston Children's Biology and Medicine Websites...

  3. aged children hbsc: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    surface area, and thickness measures were obtained. Anxiety symptoms were 13 Tackling Dyslexia at an Early Age esearchers at HMS and Boston Children's Biology and Medicine Websites...

  4. age children preliminary: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    surface area, and thickness measures were obtained. Anxiety symptoms were 17 Tackling Dyslexia at an Early Age esearchers at HMS and Boston Children's Biology and Medicine Websites...

  5. Earth: The Early Years We discuss ...

    E-Print Network [OSTI]

    Earth: The Early Years We discuss ... · What happened to the Earth during the first few billion)? · What is the relationship to (early) life? #12;Age of Earth James Ussher (17th C) biblical account: 6: 20-40 m.y. (million years!) Charles Darwin evolution >300 m.y. Lord Kelvin (1880's) cooling Earth: 50

  6. Molecular evidence of HIV-1 transmission in a criminal case

    E-Print Network [OSTI]

    Hillis, David

    to characterize HIV-1-positive samples identif, Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109; and **Section of Integrative, the patient, and a local population sample of HIV-1-positive individuals showed the victim's HIV-1 sequences

  7. HIV classification using coalescent theory

    SciTech Connect (OSTI)

    Zhang, Ming [Los Alamos National Laboratory; Letiner, Thomas K [Los Alamos National Laboratory; Korber, Bette T [Los Alamos National Laboratory

    2008-01-01T23:59:59.000Z

    Algorithms for subtype classification and breakpoint detection of HIV-I sequences are based on a classification system of HIV-l. Hence, their quality highly depend on this system. Due to the history of creation of the current HIV-I nomenclature, the current one contains inconsistencies like: The phylogenetic distance between the subtype B and D is remarkably small compared with other pairs of subtypes. In fact, it is more like the distance of a pair of subsubtypes Robertson et al. (2000); Subtypes E and I do not exist any more since they were discovered to be composed of recombinants Robertson et al. (2000); It is currently discussed whether -- instead of CRF02 being a recombinant of subtype A and G -- subtype G should be designated as a circulating recombination form (CRF) nd CRF02 as a subtype Abecasis et al. (2007); There are 8 complete and over 400 partial HIV genomes in the LANL-database which belong neither to a subtype nor to a CRF (denoted by U). Moreover, the current classification system is somehow arbitrary like all complex classification systems that were created manually. To this end, it is desirable to deduce the classification system of HIV systematically by an algorithm. Of course, this problem is not restricted to HIV, but applies to all fast mutating and recombining viruses. Our work addresses the simpler subproblem to score classifications of given input sequences of some virus species (classification denotes a partition of the input sequences in several subtypes and CRFs). To this end, we reconstruct ancestral recombination graphs (ARG) of the input sequences under restrictions determined by the given classification. These restritions are imposed in order to ensure that the reconstructed ARGs do not contradict the classification under consideration. Then, we find the ARG with maximal probability by means of Markov Chain Monte Carlo methods. The probability of the most probable ARG is interpreted as a score for the classification. To our knowledge, this particular problem was not addressed up to now. The software package Lamarc Kuhner et al. (2000) allows for sampling ARGs, but it assumes that recombination events only involve one breakpoint. However, in HIV recombinants usually have more than one breakpoint. Moreover, Lamarc does not perform an explicit breakpoint detection, but tries to find them by chance. Although this approach is suitable for most situations, it will not lead to satisfying results in case of highly recombining viruses with multiple breakpoints.

  8. HIV virus spread and evolution studied through computer modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HIV and evolution studied through computer modeling HIV virus spread and evolution studied through computer modeling This approach distinguishes between susceptible and infected...

  9. antiretroviral experienced hiv: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    virus (HIV) infectionpostpartum Vietnamese women with HIV experienced through their family and community relationships was a painful, daily reminder of their infection...

  10. Has the Early Retirement Trend Reversed? Joseph F. Quinn

    E-Print Network [OSTI]

    Huang, Jianyu

    Has the Early Retirement Trend Reversed? Joseph F. Quinn Department of Economics Boston College: figures 2.1 and 2.2; tables 2A.1 and 2A.2) has argued persuasively that this early retirement trend began.7 25.8 20.9 14.7 Age Source: Burkhauser and Quinn (1997: table 1), updated #12;3 The early retirement

  11. HIV-1 transmission linkage in an HIV-1 prevention clinical trial

    SciTech Connect (OSTI)

    Leitner, Thomas [Los Alamos National Laboratory; Campbell, Mary S [UNIV OF WASHINGTON; Mullins, James I [UNIV OF WASHINGTON; Hughes, James P [UNIV OF WASHINGTON; Wong, Kim G [UNIV OF WASHINGTON; Raugi, Dana N [UNIV OF WASHINGTON; Scrensen, Stefanie [UNIV OF WASHINGTON

    2009-01-01T23:59:59.000Z

    HIV-1 sequencing has been used extensively in epidemiologic and forensic studies to investigate patterns of HIV-1 transmission. However, the criteria for establishing genetic linkage between HIV-1 strains in HIV-1 prevention trials have not been formalized. The Partners in Prevention HSV/HIV Transmission Study (ClinicaITrials.gov NCT00194519) enrolled 3408 HIV-1 serodiscordant heterosexual African couples to determine the efficacy of genital herpes suppression with acyclovir in reducing HIV-1 transmission. The trial analysis required laboratory confirmation of HIV-1 linkage between enrolled partners in couples in which seroconversion occurred. Here we describe the process and results from HIV-1 sequencing studies used to perform transmission linkage determination in this clinical trial. Consensus Sanger sequencing of env (C2-V3-C3) and gag (p17-p24) genes was performed on plasma HIV-1 RNA from both partners within 3 months of seroconversion; env single molecule or pyrosequencing was also performed in some cases. For linkage, we required monophyletic clustering between HIV-1 sequences in the transmitting and seroconverting partners, and developed a Bayesian algorithm using genetic distances to evaluate the posterior probability of linkage of participants sequences. Adjudicators classified transmissions as linked, unlinked, or indeterminate. Among 151 seroconversion events, we found 108 (71.5%) linked, 40 (26.5%) unlinked, and 3 (2.0%) to have indeterminate transmissions. Nine (8.3%) were linked by consensus gag sequencing only and 8 (7.4%) required deep sequencing of env. In this first use of HIV-1 sequencing to establish endpoints in a large clinical trial, more than one-fourth of transmissions were unlinked to the enrolled partner, illustrating the relevance of these methods in the design of future HIV-1 prevention trials in serodiscordant couples. A hierarchy of sequencing techniques, analysis methods, and expert adjudication contributed to the linkage determination process.

  12. Design Evolution Study - Aging Options

    SciTech Connect (OSTI)

    P. McDaniel

    2002-04-05T23:59:59.000Z

    The purpose of this study is to identify options and issues for aging commercial spent nuclear fuel received for disposal at the Yucca Mountain Mined Geologic Repository. Some early shipments of commercial spent nuclear fuel to the repository may be received with high-heat-output (younger) fuel assemblies that will need to be managed to meet thermal goals for emplacement. The capability to age as much as 40,000 metric tons of heavy metal of commercial spent nuclear he1 would provide more flexibility in the design to manage this younger fuel and to decouple waste receipt and waste emplacement. The following potential aging location options are evaluated: (1) Surface aging at four locations near the North Portal; (2) Subsurface aging in the permanent emplacement drifts; and (3) Subsurface aging in a new subsurface area. The following aging container options are evaluated: (1) Complete Waste Package; (2) Stainless Steel inner liner of the waste package; (3) Dual Purpose Canisters; (4) Multi-Purpose Canisters; and (5) New disposable canister for uncanistered commercial spent nuclear fuel. Each option is compared to a ''Base Case,'' which is the expected normal waste packaging process without aging. A Value Engineering approach is used to score each option against nine technical criteria and rank the options. Open issues with each of the options and suggested future actions are also presented. Costs for aging containers and aging locations are evaluated separately. Capital costs are developed for direct costs and distributable field costs. To the extent practical, unit costs are presented. Indirect costs, operating costs, and total system life cycle costs will be evaluated outside of this study. Three recommendations for aging commercial spent nuclear fuel--subsurface, surface, and combined surface and subsurface are presented for further review in the overall design re-evaluation effort. Options that were evaluated but not recommended are: subsurface aging in a new subsurface area (high cost); surface aging in the complete waste package (risk to the waste package and impact on the Waste Handling Facility); and aging in the stainless steel liner (impact on the waste package design and new high risk operations added to the waste packaging process). The selection of a design basis for aging will be made in conjunction with the other design re-evaluation studies.

  13. Illicit substance use and risk of HIV transmission among men who have sex with men

    E-Print Network [OSTI]

    Drumright, Lydia Nicole

    2006-01-01T23:59:59.000Z

    HIVAB HIV-1/HIV-2 (rDNA) EIA. 2004. Abbott Park, IL, Abbottenzyme-linked immunoassay (EIA), and other HIV relatedHIV RNA, Western Blot, and EIA tests are used in conjunction

  14. adapted hiv prevention: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - sexual, blood borne and mother to child. However, fewer than one in five people at high risk for HIV have access Bushman, Frederic 2 PROVEN HIV PREVENTION METHODS We...

  15. adapting hiv prevention: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    - sexual, blood borne and mother to child. However, fewer than one in five people at high risk for HIV have access Bushman, Frederic 2 PROVEN HIV PREVENTION METHODS We...

  16. HIV-Encephalitis: Mechanisms for CXCL10 Induction in Astrocytes

    E-Print Network [OSTI]

    Williams, Rachel

    2009-06-23T23:59:59.000Z

    With the prevalence of HIV-associated neurocognitive disorders (HAND) increasing, understanding the mechanisms by which HIV induces neuro-inflammation and subsequent neuronal damage is of paramount importance. We hypothesized ...

  17. Childhood Cancer and Traffic-Related Air Pollution Exposure in Pregnancy and Early Life

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    and the occurrence of acute leukemia among children in Klangrisk of childhood acute leukemia at an early age. A reportleukemia (ALL) and acute myeloid leukemia (AML) (Brosselin

  18. Early usage of DO in children with and without Specific Language Impairment

    E-Print Network [OSTI]

    Blossom, Megan Stratton

    2009-09-15T23:59:59.000Z

    This study examined the early uses of DO in the spontaneous language samples of 89 children, 37 with Specific Language Impairment, age 5;0-5;6, 37 age-equivalent control children, and 15 language-equivalent control children, ...

  19. Click Dimers To Target HIV TAR RNA Conformation Sunil Kumar,

    E-Print Network [OSTI]

    Stuart, Steven J.

    with high affinity toward TAR show promising anti-HIV activity. Ribonucleic acid-protein interactionsClick Dimers To Target HIV TAR RNA Conformation Sunil Kumar, Patrick Kellish, W. Edward Robinson and length in the linker region to target the human immunode- ficiency virus type 1 (HIV-1) TAR RNA region

  20. Evolving T-cell vaccine strategies for HIV, the virus with a thousand faces

    SciTech Connect (OSTI)

    Korber, Bette [Los Alamos National Laboratory

    2009-01-01T23:59:59.000Z

    HIV's rapid global spread and the human suffering it has left in its wake have made AIDS a global heath priority for the 25 years since its discovery. Yet its capacity to rapidly evolve has made combating this virus a tremendous challenge. The obstacles to creating an effective HIV vaccine are formidable, but there are advances in the field on many fronts, in terms of novel vectors, adjuvants, and antigen design strategies. SIV live attenuated vaccine models are able to confer protection against heterologous challenge, and this continues to provide opportunities to explore the biological underpinnings of a protective effect (9). More indirect, but equally important, is new understanding regarding the biology of acute infection (43), the role of immune response in long-term non-progression (6,62, 81), and defining characteristics of broadly neutralizing antibodies (4). In this review we will focus on summarizing strategies directed towards a single issue, that of contending with HIV variation in terms of designing aT-cell vaccine. The strategies that prove most effective in this area can ultimately be combined with the best strategies under development in other areas, with the hope of ultimately converging on a viable vaccine candidate. Only two large HIV vaccine efficacy trials have been completed and both have failed to prevent infection or confer a benefit to infected individual (23,34), but there is ample reason to continue our efforts. A historic breakthrough came in 1996, when it was realized that although the virus could escape from a single antiretroviral (ARV) therapy, it could be thwarted by a combination of medications that simultaneously targeted different parts of the virus (HAART) (38). This revelation came after 15 years of research, thought, and clinical testing; to enable that vital progress the research and clinical communities had to first define and understand, then develop a strategy to counter, the remarkable evolutionary potential of the virus. HAART, for the first time, provided an effective treatment to help those with living with HIV stay healthy. Nonetheless, the treatment has limitations. People with HIV face a lifetime of expensive daily multi-drug regimens, often with side effects; drug resistance at the individual and population level are issues (56); and universal access, despite substantial progress, is a dream not yet realized for many of the millions of the world's poor who are living with HIV (68). These issues, combined with the growing numbers of people infected globally and impact of HIV on society, make the development of an HIV vaccine or a prophylactic prevention strategy a crucial if elusive goal. In some ways, the history of HIV vaccine deVelopment has paralleled the early stages of designing effective therapy. We had to test the simple strategies first, but meanwhile the story of the impact of diversity from an immunological perspective is still unfolding, and novel ideas countermeasures are being explored.

  1. Early age delamination in concrete pavements made with gravel aggregates

    E-Print Network [OSTI]

    Liu, Juanyu

    2009-06-02T23:59:59.000Z

    , and application of ultra-fine fly ash among others. A fractional factorial design (Taguchi method) based on ?orthogonal array? (Taguchi et al. 1993) was used to evaluate the effects of various factors on the bonding strength. Test runs were made according... of the aggregate can be represented by an overall rating of the contribution of aggregate to the bonding performance. Non-aggregate factors include water/cementitious ratio (w/cm), cement factor, ultra-fly ash content, and curing quality. The overall effects...

  2. Notice of Intention: Unreduced Early Retirement 1. This form should be used if you wish to participate in the unreduced early retirement program. For this program

    E-Print Network [OSTI]

    Toronto, University of

    Notice of Intention: Unreduced Early Retirement 1. This form should be used if you wish to participate in the unreduced early retirement program. For this program faculty members must be age 60 or more early retirement program must be submitted to your Unit Head at least one year in advance

  3. Whither India? Ten Lessons Learned from the HIV Epidemic in Africa

    E-Print Network [OSTI]

    Potts, Malcolm; Walsh, Julia

    2002-01-01T23:59:59.000Z

    i31-9 Whither India? Lessons learned from the HIV epidemic139. Whither India? Lessons learned from the HIV epidemic in81. Whither India? Lessons learned from the HIV epidemic in

  4. E-Print Network 3.0 - ao hiv em Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ex Vivo-Expanded Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Infusion in HIV-Infected Patients Summary: , Edwards lack of disease in HIV-1-infected...

  5. Characterization of Glycosylation Profiles of HIV-1 Transmitted/Founder Envelopes by Mass Spectrometry

    E-Print Network [OSTI]

    Go, Eden P.; Hewawasam, Geetha; Lio, Hua-Xin; Chen, Haiyan; Ping, Li-Hua; Anderson, Jeffrey A.; Hua, David C.; Haynes, Barton F.; Desaire, Heather

    2011-08-01T23:59:59.000Z

    The analysis of HIV-1 envelope carbohydrates is critical to understanding their roles in HIV-1 transmission as well as in binding of envelope to HIV-1 antibodies. However, direct analysis of protein glycosylation by ...

  6. Apply early! Limited enrollment.

    E-Print Network [OSTI]

    volcano. Experience the culture and history of Hawaii, and the impact of human activitiesApply early! Limited enrollment. Environmental Science in the Hawaiian Islands Observe, research

  7. Aging of gaseous detectors

    SciTech Connect (OSTI)

    Va'Vra, J.

    1990-03-01T23:59:59.000Z

    This paper makes an overview of developments in the wire chamber aging field since the wire chamber aging workshop held at the Lawrence Berkeley Laboratory, Berkeley, California on January 16--17, 1986. The author discusses new techniques to analyze the gas impurities and the wire aging products, wire nonaging'' in clean systems, wire aging in systems containing various impurities, various examples of problems which can prime'' surfaces prior to the occurrence of the aging, and some recent aging experience with the SSC micro-straw tubes.'' 35 refs., 10 figs., 2 tabs.

  8. Epidemiology of Malignant Tumors among HIV-infected Population in China

    E-Print Network [OSTI]

    Zhu, Weiming

    2013-01-01T23:59:59.000Z

    the HIV/AIDS Epidemic in China. 2010, Beijing. 21. RothmanCHINA. OF INCIDENT KAPOSI SARCOMA AMONG HIV/AIDS COHORT IN CHINA. (

  9. Willingness to treat HIV-positive patients at different stages of medical education and experience.

    E-Print Network [OSTI]

    Radecki, S; Shapiro, J; Thrupp, L D; Gandhi, S M; Sangha, S S; Miller, R B

    1999-01-01T23:59:59.000Z

    patients and willingness to treat HIV-infected patients. Jprofessions students to treat patients with AIDS. Acad Medstu- dents' willingness to treat HIV-infected patients. Acad

  10. DISCUSSION PAPER 22-23 November 2007 Peer Review Active Ageing Strategies to Strengthen

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    have introduced early retirement schemes, which significantly lowered activity 1 I thank, for its help unemployment, in the early 1980s and in the early 1990s. This Continental model of retirement is now questioned: a substantial postponement of the retirement age, in order to reduce the burden of pensions costs

  11. HIV-AIDS Information Resources from the NLM - ACIO

    SciTech Connect (OSTI)

    Templin-Branner, W.

    2010-10-01T23:59:59.000Z

    As the treatment and management of HIV/AIDS continues to evolve with new scientific breakthroughs, treatment discoveries, and management challenges, it is difficult for people living with HIV/AIDS and those who care for them to keep up with the latest information on HIV/AIDS screening and testing, prevention, treatment, and research. The National Library of Medicine (NLM), of the National Institutes of Health, has a wealth of health information resources freely available on the Internet to address these needs.

  12. TCRS Retirees: Health Insurance Continuation Under Age 65 Eligibility and Service Requirements

    E-Print Network [OSTI]

    Dasgupta, Dipankar

    regardless of age; age 55 with 10 years of service for early retirement. 2. To continue current health plan. Must meet requirements for TCRS retirement: Age 60 with 10 years of service or 30 years of service in insurance plan 3 years or more immediately prior to retirement b. Retirement benefits and insurance must

  13. ampliscreen hiv-1 test: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ampliscreen hiv-1 test First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 The Fitness Landscape of HIV-1...

  14. ORIGINAL PAPER Rates and Correlates of HIV and STI Infection

    E-Print Network [OSTI]

    Gelman, Andrew

    (&) Division of Clinical Phenomenology, New York State Psychiatric Institute, 1051, Riverside Drive, Unit 56ORIGINAL PAPER Rates and Correlates of HIV and STI Infection Among Homeless Women Carol L. M. Caton counterparts [1­3]. Moreover, mortality studies have demonstrated that HIV/ AIDS is a leading cause of death

  15. Pioneering the nuclear age

    SciTech Connect (OSTI)

    Seaborg, G.T.

    1988-09-01T23:59:59.000Z

    This paper reviews the historical aspects of nuclear physics. The scientific aspects of the early transuranium elements are discussed and arms control measures are reviewed. 11 refs., 14 figs. (LSP)

  16. Parylene C Aging Studies.

    SciTech Connect (OSTI)

    Achyuthan, Komandoor; Sawyer, Patricia Sue.; Mata, Guillermo Adrian; White II, Gregory Von; Bernstein, Robert

    2014-09-01T23:59:59.000Z

    Parylene C is used in a device because of its conformable deposition and other advantages. Techniques to study Parylene C aging were developed, and %22lessons learned%22 that could be utilized for future studies are the result of this initial study. Differential Scanning Calorimetry yielded temperature ranges for Parylene C aging as well as post-deposition treatment. Post-deposition techniques are suggested to improve Parylene C performance. Sample preparation was critical to aging regimen. Short-term (~40 days) aging experiments with free standing and ceramic-supported Parylene C films highlighted %22lessons learned%22 which stressed further investigations in order to refine sample preparation (film thickness, single sided uniform coating, machine versus laser cutting, annealing time, temperature) and testing issues (%22necking%22) for robust accelerated aging of Parylene C.

  17. COOEE bitumen: chemical aging

    E-Print Network [OSTI]

    Lemarchand, Claire A; Dyre, Jeppe C; Hansen, Jesper S

    2013-01-01T23:59:59.000Z

    We study chemical aging in "COOEE bitumen" using molecular dynamic simulations. The model bitumen is composed of four realistic molecule types: saturated hydrocarbon, resinous oil, resin, and asphaltene. The aging reaction is modelled by the chemical reaction: "2 resins $\\rightarrow$ 1 asphaltene". Molecular dynamic simulations of four bitumen compositions, obtained by a repeated application of the aging reaction, are performed. The stress autocorrelation function, the fluid structure, the rotational dynamics of the plane aromatic molecules, and the diffusivity of each molecule, are determined for the four different compositions. The aging reaction causes a significant dynamics slowdown, which is correlated to the aggregation of asphaltene molecules in larger and dynamically slower nanoaggregates. Finally, a detailed description of the role of each molecule types in the aggregation and aging processes is given.

  18. Identification of full-length transmitted/founder viruses and their progeny in primary HIV-1 infection

    SciTech Connect (OSTI)

    Korber, Bette [Los Alamos National Laboratory; Hraber, Peter [Los Alamos National Laboratory; Giorgi, Elena [Los Alamos National Laboratory; Bhattacharya, T [Los Alamos National Laboratory

    2009-01-01T23:59:59.000Z

    Identification of transmitted/founder virus genomes and their progeny by is a novel strategy for probing the molecular basis of HIV-1 transmission and for evaluating the genetic imprint of viral and host factors that act to constrain or facilitate virus replication. Here, we show in a cohort of twelve acutely infected subjects (9 clade B; 3 clade C), that complete genomic sequences of transmitted/founder viruses could be inferred using single genome amplification of plasma viral RNA, direct amplicon sequencing, and a model of random virus evolution. This allowed for the precise identification, chemical synthesis, molecular cloning, and biological analysis of those viruses actually responsible for productive clinical infection and for a comprehensive mapping of sequential viral genomes and proteomes for mutations that are necessary or incidental to the establishment of HIV-1 persistence. Transmitted/founder viruses were CD4 and CCR5 tropic, replicated preferentially in activated primary T-Iymphocytes but not monocyte-derived macrophages, and were effectively shielded from most heterologous or broadly neutralizing antibodies. By 3 months of infection, the evolving viral quasispecies in three subjects showed mutational fixation at only 2-5 discreet genomic loci. By 6-12 months, mutational fixation was evident at 18-27 genomic loci. Some, but not all, of these mutations were attributable to virus escape from cytotoxic Tlymphocytes or neutralizing antibodies, suggesting that other viral or host factors may influence early HIV -1 fitness.

  19. HIV/AIDS Information Resources from NLM

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville Power AdministrationField8,Dist.NewofGeothermal HeatonHEP/NERSC/ASCRJune 2012Wind9-1941HIV/AIDS

  20. Aging, Work, and Retirement among Late-Career Faculty at the University of California A Trustee Grant Proposal to

    E-Print Network [OSTI]

    Iglesia, Enrique

    Voluntary Early Retirement Incentive Programs of the early 1990s (verips 1, 2, 3)--to better understandAging, Work, and Retirement among Late-Career Faculty at the University of California A Trustee and needs of faculty in the early stages of academic careers, in terms of recruitment and retention

  1. HIV transcription is induced with some forms of cell killing

    SciTech Connect (OSTI)

    Woloschak, G.E. [Argonne National Lab., IL (United States); Schreck, S. [Argonne National Lab., IL (United States)][South Carolina Univ., Columbia, SC (United States). Dept. of Chemistry; Panozzo, J. [Loyola Univ. Medical Center, Maywood, IL (United States); Chang-Liu, C.-M. [Argonne National Lab., IL (United States); Libertin, C.R. [Loyola Univ. Medical Center, Maywood, IL (United States)

    1996-11-01T23:59:59.000Z

    Using HeLa cells stably transfected with an HIV-LTR-CAT construct`, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {Gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires function p53, which is missing in HeLa cells. For all other agents, HIV-LTR induction was dose-dependent and correlated with the amount of cell killing that occurred in the culture.

  2. ORIGINAL PAPER Recognition of early Carboniferous alkaline granite

    E-Print Network [OSTI]

    Siebel, Wolfgang

    ORIGINAL PAPER Recognition of early Carboniferous alkaline granite in the southern Altai orogen for the Bulgen alkaline granite yield crystallization ages of 358 ± 4 Ma (SHRIMP) and 354 ± 4 Ma (LA-orogenic granitoids (460­375 Ma) in this region. The Bulgen granite has high SiO2, total alkalis, rare earth elements

  3. Original article Response of Pinus pinaster Ait. provenances at early

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    . pinaster in response to water shortage. These physiological adaptations complement known morphologicalOriginal article Response of Pinus pinaster Ait. provenances at early age to water supply. I. Water evolution of tissue water relations was assessed in 1-year-old seedlings of four Pinus pinaster Ait. prove

  4. The development of early terrestrial ecosystems

    E-Print Network [OSTI]

    Selden, Paul A.; Edwards, Dianne

    1993-01-01T23:59:59.000Z

    ,575-599. Burgess, N.D. & Edwards, D. (1991). Classification of uppermost Ordovician to Lower Devonian tubular and filamentous macerals from the Anglo-Welsh Basin. Botanical Journal of the Linnean Society 106,41-66. Campbell, S.E. (1979). Soil stabilization...., Massa, D. & Boucot A J . (1982). Caradocian land plant microfossils from Libya. Geology 10.197-201. Gray, J., Theron, J.N. & Boucot, A J . (1986). Age of the Cedarberg Formation, South Africa and early land plant evolution. Geological Magazine 123...

  5. Children Are the Wealth of the Poor: Prevention of Mother-to-Child Transmission of HIV in Haiti

    E-Print Network [OSTI]

    Denney, Rachel

    2012-08-31T23:59:59.000Z

    At roughly two percent, Haiti has one of the highest HIV prevalence rates in the Caribbean. This thesis examines HIV transmission in Haiti, specifically the transmission of HIV from mother to child during pregnancy, labor, and breastfeeding. Though...

  6. AIDS. Author manuscript Early antiretroviral therapy of HIV-infected infants in resource-limited

    E-Print Network [OSTI]

    Boyer, Edmond

    : U897, Universit Victor Segalen - Bordeaux IIé , FR Pediatric, Adolescent, and Maternal AIDS Branch3 are receiving therapy . Barriers to pediatric treatment include lack of appropriate testing technology% [10 pediatric antiretroviral drug formulations, lack of personnel with health care expertise in treatment

  7. Bitcoin and The Age of Bespoke Silicon Michael Bedford Taylor

    E-Print Network [OSTI]

    Wang, Deli

    Bitcoin and The Age of Bespoke Silicon Michael Bedford Taylor University of California, San Diego ABSTRACT Recently, the Bitcoin cryptocurrency has been an interna- tional sensation. This paper tells the story of Bitcoin hard- ware: how a group of early-adopters self-organized and fi- nanced the creation

  8. antenatal hiv testing: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HIV Testing Day (NHTD) is June 27. NHTD is sponsored by the National Association of People with AIDS to encourage persons at risk to receive voluntary counseling and testing for...

  9. HIV genetic research to be discussed at Bradbury Science Museum...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12 Tanmoy Bhattacharya will talk about the Lab's research in HIV genetics and how the deluge of new data is going to impact its future. February 7, 2014 Bradbury Science Museum...

  10. advanced hiv disease: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HIV-1 infection, with extremes of very rapid disease progression (,2 years) and long-term non-progression (.15 years). To reveal additional host genetic factors that may impact on...

  11. Decision making in the HIV/AIDS supply chain

    E-Print Network [OSTI]

    Cao, Elaine Phu

    2007-01-01T23:59:59.000Z

    During the first two decades of HIV/AIDS awareness, the U.S. and foreign governments responded slowly to the crisis. In contrast today, as the pandemic continues, initiatives of nonprofit organizations have dramatically ...

  12. ao hiv entre: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Gaborone from September 19th to 22nd, 2012. Next month's Tlaleletso will discuss HIV and Cancer. If there are other topics you would like Bushman, Frederic 10 PROPOSTA E...

  13. Emerging nanotechnology approaches for HIV/AIDS treatment and prevention

    E-Print Network [OSTI]

    von Andrian, Ulrich H.

    Emerging nanotechnology approaches for HIV/AIDS treatment and prevention The emergence of AIDS effects and is ineffective in patients in whom the virus develops resistance. Nanotechnology of nanotechnology to provide more effective treatment and preven

  14. New Age Teaching: Beyond Didactics

    E-Print Network [OSTI]

    Vlaovic, Peter D; McDougall, Elspeth M

    2006-01-01T23:59:59.000Z

    Age Teaching: Beyond Didactics TheScientificWorldJOURNAL (New age teaching: beyond didactics. TSW Urology 1, 75–85.New Age Teaching: Beyond Didactics Peter D. Vlaovic and

  15. CHERRY: CHECKPOINTED EARLY RESOURCE RECYCLING

    E-Print Network [OSTI]

    Torrellas, Josep

    : Decouple recycling from retirement #12;Cherry: Checkpointed Early Resource Recycling in Out Slide 4/41 PROPOSAL: EARLY RECYCLING Decouple resource recycling from instruction retirement Recycle1 2 3 CHERRY: CHECKPOINTED EARLY RESOURCE RECYCLING Jos´e F. Mart´inez1 , Jose Renau2 Michael C

  16. Aging in community

    E-Print Network [OSTI]

    Fay, Justin (Justin Thomas)

    2008-01-01T23:59:59.000Z

    Baby Boomers are on the brink of retirement. According to U.S. Census Bureau projections, the number of people aged 65 and over will more than double in the coming decades, growing from 35 million in 2000 to 72 million in ...

  17. Factors important for the establishment and maintenance of HIV-1 latency in CD4 T cells

    E-Print Network [OSTI]

    Soto, Paula Campos

    2008-01-01T23:59:59.000Z

    the Establishment and Maintenance of HIV-1 Latency in CD4 TFunction, generation, and maintenance. Annu Rev Immunol. 19.the Establishment and Maintenance of HIV-1 Latency in CD4 T

  18. E-Print Network 3.0 - access hiv services Sample Search Results

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HIV Summary: on the prevention of HIV and STIs to women who do not frequently access health care services. Although prenatal care... fees. Mother-infant pairs had access to...

  19. Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens

    DOE Patents [OSTI]

    Korber, Bette T. (Los Alamos, NM); Fischer, William (Los Alamos, NM); Liao, Hua-Xin (Durham, NC); Haynes, Barton F. (Durham, NC); Letvin, Norman (Boston, MA); Hahn; Beatrice H. (Birmingham, AL)

    2011-05-31T23:59:59.000Z

    The present invention relates to mosaic clade M HIV-1 Env polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

  20. Impact of HIV/AIDS on the Agricultural Sector in Northern Namibia

    E-Print Network [OSTI]

    Carter, Charles Russell

    2011-02-22T23:59:59.000Z

    In agrarian societies, HIV/AIDS extends far beyond the realm of healthcare into agricultural production and food security as well. Namibia is a developing country with a large portion of its population involved in agriculture; the average HIV...

  1. Modeling the transmission of HIV in the Texas State Prison population

    E-Print Network [OSTI]

    Tay, Edward Chor-Ying

    2000-01-01T23:59:59.000Z

    via intravenous drug use in a Texas State prison population. By developing a model to track the movement of HIV in the prison, public health authorities could suggest policies to better serve those HIV positive prisoners released into the general...

  2. Early retirement for weaponeers?

    SciTech Connect (OSTI)

    Weisman, J.

    1994-07-01T23:59:59.000Z

    Department of Energy`s Lawrence Livermore Laboratory`s once-vital nuclear weapons division is now in dire straits. The laboratory was established in 1952, during the titanic struggle over the hydrogen bomb, has grown steadily from $7 million to its peak of $1.1 billion in 1991. The future for key members of their most experienced weapons design team is uncertain. Over the past two years, Livermore`s operating budget has fallen by 12.5 percent or $127.6 million. Nearly 750 employees, 10 percent of the work force, accepted early retirement offers last year. Further budget cuts will force another 300 to 600 personnel out by the end of 1995. The future resides in the U.S. Congress.

  3. Viscosity and dissipation - early stages

    E-Print Network [OSTI]

    P. Bozek

    2009-01-15T23:59:59.000Z

    A very early start up time of the hydrodynamic evolution is needed in order to reproduce observations from relativistic heavy-ion collisions experiments. At such early times the systems is still not locally equilibrated. Another source of deviations from local equilibrium is the viscosity of the fluid. We study these effects at very early times to obtain a dynamical prescription for the transition from an early 2-dimensional expansion to a nearly equilibrated 3-dimensional expansion at latter stages. The role of viscosity at latter stages of the evolution is also illustrated.

  4. receive DOE Early Career Award

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    hydrological controls on carbon cycling in flood plain ecosystems into Earth System Models (ESM). "The DOE Early Career Research Award represents both a significant honor...

  5. SAARC J. TUBER. LUNG DIS. HIV/AIDS 2008 V (1)......... OPPORTUNISTIC INTESTINAL PROTOZOAN PARASITIC INFECTION IN HIV POSITIVE PATIENT IN JAMNAGAR, GUJARAT

    E-Print Network [OSTI]

    Gupta M; Sinha M; Raizada N

    The case definition of AIDS encompasses a spectrum of infections and malignancies, labelled as opportunistic infections. In recent years, numerous studies have outlined the emergence of opportunistic gastrointestinal protozoa that have caused diarrhoeal illness among HIV – AIDS patients. Purpose of present study was to determine the prevalence of opportunistic intestinal protozoal parasites in HIV positive patients with or without diarrhoea. A total of 100 stool samples of HIV positive patients were examined for protozoal parasites by microscopy. Protozoal parasites were detected in 25 HIV positive patients; in 41.37 % of patients with diarrhoea and in 2.38 % of patients without diarrhoea. Isospora belli appeared to be a predominant parasite associated with diarrhoea among HIV patients. Cryptosporidium revealed of its asymptomatic carriage along with its association with acute and chronic diarrhoea. Prevalence of Microsporidia and Cyclospora cayetenensis was found to be very low. Key words: HIV, diarrhoea, opportunistic protozoa.

  6. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    John S. Abughazaleh; Mushtaq Ahmed; Ashok Anand; John H. Anderson; Charles Benham; Fred D. Brent; Thomas E. Chance; William K. Davis; Raymond F. Drnevich; Larry Hall; Ming He; Stephen A. Lang; David Mintner; Wendy Moore; Jimmy O. Ong; George Potoczniak; Adela G. Sanchez; Charles H. Schrader; Lalit S. Shah; Kalapi D. Sheth; Phil J. Shires; Rae Song

    2001-05-17T23:59:59.000Z

    The overall objective of this project is the three-phase development of an Early Entrance Coproduction Plant (EECP) that produces at least one product from at least two of the following three categories: Electric power (or heat); Fuels; and Chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or some other carbonaceous feedstock, such as petroleum coke. The objective of Phase I was to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Testing (RD and T) Plan for implementation in Phase II. This objective has now been accomplished. A specific site, Motiva Refinery in Port Arthur, Texas, has been selected as the location best suited for the EECP. The accomplishments of Phase I are discussed in detail in this Phase I Concept Report. A RD and T Plan and a preliminary project financing plan have been developed and are submitted separately from this report.

  7. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    John S. Abughazaleh; Mushtaq Ahmed; Ashok Anand; John H. Anderson; Charles Benham; Fred D. Brent; Thomas E. Chance; William K. Davis; Raymond F. Drnevich; Larry Hall; Ming He; Stephen A. Lang; Jimmy O. Ong; Sarah J. Patel; George Potoczniak; Adela G. Sanchez; Charles H. Schrader; Lalit S. Shah; Phil J. Shires; Rae Song

    2001-02-15T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or other carbonaceous feedstocks. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Testing Plan (RD and T) for implementation in Phase II. The objective of Phase II is to implement the RD and T as outlined in the Phase I RD and T Plan to enhance the development and commercial acceptance of coproduction technology that produces high-value products, particularly those that are critical to our domestic fuel and power requirements. The project will resolve critical knowledge and technology gaps on the integration of gasification and downstream processing to coproduce some combination of power, fuels, and chemicals from coal and/or other carbonaceous feedstocks. The objective of Phase III is to develop an engineering design package and a financing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information that will be needed to move the EECP forward to detailed design, construction, and operation by industry.

  8. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Mushtaq Ahmed; John H. Anderson; Earl R. Berry; Troy Raybold; Lalit S. Shah; Kenneth A. Yackly

    2003-12-16T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or other carbonaceous feedstocks. The objectives of Phase I were to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan for implementation in Phase II; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology that produces high-value products, particularly those that are critical to our domestic fuel and power requirements. The work performed under Phase II will resolve critical knowledge and technology gaps on the integration of gasification and downstream processing to coproduce some combination of power, fuels, and chemicals from coal and/or other carbonaceous feedstocks. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation.

  9. Early Entrance Coproduction Plant

    SciTech Connect (OSTI)

    Mushtaq Ahmed; John H. Anderson; Earl R. Berry; Troy Raybold; Lalit S. Shah; Kenneth A. Yackly

    2004-01-26T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or other carbonaceous feedstocks. The objectives of Phase I were to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan for implementation in Phase II; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology that produces high-value products, particularly those that are critical to our domestic fuel and power requirements. The work performed under Phase II will resolve critical knowledge and technology gaps on the integration of gasification and downstream processing to coproduce some combination of power, fuels, and chemicals from coal and/or other carbonaceous feedstocks. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation.

  10. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    John S. Abughazaleh; Mushtaq Ahmed; Ashok Anand; John H. Anderson; Charles Benham; Fred D. Brent; Thomas E. Chance; William K. Davis; Raymond F. Drnevich; Larry Hall; Ming He; Stephen A. Lang; Jimmy O. Ong; Sarah J. Patel; George Potoczniak; Adela G. Sanchez; Charles H. Schrader; Lalit S. Shah; Phil J. Shires; Rae Song

    2000-10-26T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or other carbonaceous feedstock. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Testing Plan (RD and T) for implementation in Phase II. The objective of Phase II is to implement the RD and T as outlined in the Phase I RD and T Plan to enhance the development and commercial acceptance of coproduction technology that produces high-value products, particularly those that are critical to our domestic fuel and power requirements. The project will resolve critical knowledge and technology gaps on the integration of gasification and downstream processing to coproduce some combination of power, fuels, and chemicals from coal and other feedstocks. The objective of Phase III is to develop an engineering design package and a financing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information that will be needed to move the EECP forward to detailed design, construction, and operation by industry.

  11. Wrapping up the bad news - HIV assembly and release

    E-Print Network [OSTI]

    Meng, Bo; Lever, Andrew ML

    2013-01-10T23:59:59.000Z

    comprising four major subdomains – Matrix (MA), Capsid (CA), Nucleocapsid (NC) and p6. Flanking NC are two small ‘spacer’ peptides SP1 (p2) and SP2 (p1). The assembly of capsid like particles in HIV and other retroviruses can be achieved by the viral Gag pro... in HIV is now understood in remarkable detail; however, there are some notable unanswered questions. tic ‘extended’ Gag assemblies with dimensions compa- rable to a wild type viral capsid can be formed in the presence of lipid membranes and nucleic acid...

  12. Training for Early Career Researchers

    E-Print Network [OSTI]

    Greifswald, Ernst-Moritz-Arndt-Universität

    Training for Early Career Researchers Research Management Training for 16 ­ 17 September 2014 training in an intensive, yet effective workshop form over two days. There is a strong emphasis on European Management Training for Early Career Researchers 16 ­ 17 September 2014 in Hamburg #12;

  13. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    John H. Anderson; William K. Davis; Thomas W. Sloop

    2001-03-21T23:59:59.000Z

    As part of the Department of Energy's (DOE) Gasification Technologies and Transportation Fuels and Chemicals programs, DOE and Texaco are partners through Cooperative Agreement DE-FC26-99FT40658 to determine the feasibility of developing, constructing and operating an Early Entrance Coproduction Plant (EECP). The overall objective of the project is the three-phase development of an EECP that produces at least one product from at least two of the following three categories: Electric power (or heat); Fuels; and Chemicals. The objective is to have these products produced by technologies capable of using synthesis gas derived from coal and/or some other carbonaceous feedstock, such as petroleum coke. The objective of Phase I was to determine the feasibility and define the concept for the EECP located at a specific site and to develop a Research, Development, and Testing (RD and T) Plan for implementation in Phase II. This objective has now been accomplished. A specific site, Motiva Refinery in Port Arthur, Texas, has been selected as the location best suited for the EECP. The specific work requirements of Phase I included: Prepare an EECP Preliminary Concept Report covering Tasks 2-8 specified in the Cooperative Agreement; Develop a Research, Development, and Testing (RD and T) Plan as specified in Task 9 of the Cooperative Agreement for implementation in Phase II; and Develop a Preliminary Project Financing Plan for the EECP Project as specified in Task 10 of the Cooperative Agreement. This document is the Preliminary Project Financing Plan for the design, construction, and operation of the EECP at the Motiva Port Arthur Refinery.

  14. access hiv-1 test: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    access hiv-1 test First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 REVIEW Open Access The macrophage in...

  15. Amplification Dynamics: Predicting the Effect of HIV on Tuberculosis Outbreaks

    E-Print Network [OSTI]

    Blower, Sally

    the virulence of M. tuberculosis and in the planned elimination of tuberculosis in the United States. Key Words of tuberculosis in the United States and for global control of this disease. Previously, we (20­25) and other, but that this amplification effect of HIV on tuberculosis outbreaks is very sensitive to the tuberculosis treatment rate

  16. Modeling HIV Immune Response and Validation with Clinical Data

    E-Print Network [OSTI]

    and parameters describing vi- ral production and clearance, cell infection and death rate, treatment efficacy, and stimulation by antigens other than HIV. A stability analysis illustrates the capability of this model in admitting multiple locally asymptotically stable (locally a.s.) off-treatment equilibria. The phenomenon

  17. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Fred D. Brent; Lalit Shah; Earl Berry; Charles H. Schrader; John Anderson; Ming He; James F. Stevens; Centha A. Davis; Michael Henley; Jerome Mayer; Harry Tsang; Jimell Erwin; Jennifer Adams; Michael Tillman; Chris Taylor; Marjan J. Roos; Robert F. Earhart

    2004-01-27T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems was assessed for technical risks and barriers. A plan was developed to mitigate the identified risks (Phase II RD&T Plan, October 2000). The potential technical and economic risks to the EECP from Task 2.5 can be mitigated by demonstrating that the end-use products derived from the upgrading of the F-T synthesis total liquid product can meet or exceed current specifications for the manufacture of ethylene and propylene chemicals from F-T naphtha, for the generation of hydrogen from F-T naphtha to power fuel cells, for direct blending of F-T diesels into transportation fuels, for the conversion of F-T heavy product wax to transportation fuels, and the conversion of F-T Heavy product wax to a valuable high melting point food-grade specialty wax product. Product evaluations conducted under Task 2.5 of Phase II successfully mitigated the above technical and economic risks to the EECP with the development of product yields and product qualities for the production of chemicals, transportation fuels, and specialty food-grade waxes from the F-T synthesis products.

  18. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    David Storm; Govanon Nongbri; Steve Decanio; Ming He; Lalit Shah; Charles Schrader; Earl Berry; Peter Ricci; Belma Demirel; Charles Benham; Mark Bohn

    2004-01-12T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, Inc., GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. During Phase I, a design basis for the Fischer-Tropsch Synthesis section was developed based on limited experience with the specified feed gas and operating conditions. The objective of this Task in Phase II RD&T work was to confirm the performance of the F-T reactor at the set design conditions. Although much of the research, development, and testing work were done by TES outside of this project, several important issues were addressed in this phase of the project. They included Rejuvenation/Regeneration of the Fischer-Tropsch Catalyst, online Catalyst Withdrawal and Addition from the synthesis reactor, and the Fischer-Tropsch Design Basis Confirmation. In Phase III the results from these RD&T work will be incorporated in developing the engineering design package. This Topical Report documents the Phase II RD&T work that was completed for this task.

  19. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    John Anderson; Charles Schrader

    2004-01-26T23:59:59.000Z

    In 1999, the U. S. Department of Energy (DOE) awarded a Cooperative Agreement to Texaco Energy Systems Inc. to provide a preliminary engineering design of an Early Entrance Coproduction Plant (EECP). Since the award, continuous and diligent work has been undertaken to achieve the design of an economical facility that makes strides toward attaining the goal of DOE's Vision 21 Program. The objective of the EECP is to convert coal and/or petroleum coke to power while coproducing transportation fuels, chemicals, and useful utilities such as steam. This objective is being pursued in a three-phase effort through the partnership of the DOE with prime contractor Texaco Energy Systems, LLC. (TES), the successor to Texaco Energy Systems, Inc. The key subcontractors to TES include General Electric (GE), Praxair, and Kellogg Brown and Root. ChevronTexaco provided gasification technology and Rentech Inc.'s Fischer-Tropsch (F-T) technology that has been developed for non-natural gas sources. GE provided gas turbine technology for the combustion of low energy content gas. Praxair provided air separation technology and KBR provided engineering to integrate the facility. A conceptual design was completed in Phase I and the report was accepted by the DOE in May 2001. The Phase I work identified risks and critical research, development, and testing that would improve the probability of technical success of the EECP. The objective of Phase II was to mitigate the risks by executing research, development, and testing. Results from the Phase II work are the subject of this report. As the work of Phase II concluded, it became evident that sufficient, but not necessarily complete, technical information and data would be available to begin Phase III - Preliminary Engineering Design. Work in Phase II requires additional technical development work to correctly apply technology at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The decision to proceed with Phase III centers on locating a new site and favorable commercial and economic factors.

  20. Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease

    SciTech Connect (OSTI)

    Liu, Zhigang; Wang, Yong; Brunzelle, Joseph; Kovari, Iulia A.; Kovari, Ladislau C. (WSU-MED); (NWU)

    2012-03-27T23:59:59.000Z

    Under drug selection pressure, emerging mutations render HIV-1 protease drug resistant, leading to the therapy failure in anti-HIV treatment. It is known that nine substrate cleavage site peptides bind to wild type (WT) HIV-1 protease in a conserved pattern. However, how the multidrug-resistant (MDR) HIV-1 protease binds to the substrate cleavage site peptides is yet to be determined. MDR769 HIV-1 protease (resistant mutations at residues 10, 36, 46, 54, 62, 63, 71, 82, 84, and 90) was selected for present study to understand the binding to its natural substrates. MDR769 HIV-1 protease was co-crystallized with nine substrate cleavage site hepta-peptides. Crystallographic studies show that MDR769 HIV-1 protease has an expanded substrate envelope with wide open flaps. Furthermore, ligand binding energy calculations indicate weaker binding in MDR769 HIV-1 protease-substrate complexes. These results help in designing the next generation of HIV-1 protease inhibitors by targeting the MDR HIV-1 protease.

  1. Living and Dying Abroad: Aspects of Egyptian Cultural Identity in Late Bronze Age and Early Iron Age Canaan

    E-Print Network [OSTI]

    Pierce, Krystal Victoria Lords

    2013-01-01T23:59:59.000Z

    on the doorjamb read …k Htp r st=f n… (“… content in hison the doorjamb read …k Htp r st=f n…, meaning “… content inprescriptions of the Egyptian Htp di nsw” (Holthoer 1977:

  2. Living and Dying Abroad: Aspects of Egyptian Cultural Identity in Late Bronze Age and Early Iron Age Canaan

    E-Print Network [OSTI]

    Pierce, Krystal Victoria Lords

    2013-01-01T23:59:59.000Z

    Encyclopedia of Ancient Egypt. Volume I. Oxford. 161-162.1994 Amulets of Ancient Egypt. London. Anzaldúa, G. 1987Encyclopedia of Ancient Egypt. Volume III. Oxford. 179-181.

  3. HIV-1 Tat Is a Natively Unfolded Protein THE SOLUTION CONFORMATION AND DYNAMICS OF REDUCED HIV-1 Tat-(172)

    E-Print Network [OSTI]

    O'Neil, Joe

    with the ability of Tat protein to interact with a wide variety of proteins and nucleic acid and support (transactivation response element (TAR)) formed by the first 59 nucleotides of the HIV-1 RNA (4). Tat stimulates binding site (8) and that the affinity of the Tat-cyclin T1-cyclin- dependent kinase 9 complex for TAR

  4. Tobacco use in HIV infected patients; Second Revised manuscript ID AVT-07-OA-0582 Living With HIV, Antiretroviral Treatment Experience

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    , Antiretroviral Treatment Experience and Tobacco Smoking: Results From a Multi-Site Cross-Sectional Study a Xavier-infected patient care were asked to complete a self-administered questionnaire, assessing smoking habits, dependence, cessation motivation, other substance abuse, socio-cultural characteristics, life with HIV

  5. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Abdalla H. Ali; Raj Kamarthi; John H. Anderson; Earl R. Berry; Charles H. Schrader; Lalit S. Shah

    2003-04-16T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. During Phase I the team identified the integration of the water produced in the F-T synthesis section with the gasification section as an area of potential synergy. By utilizing the F-T water in the petroleum coke slurry for the gasifier, the EECP can eliminate a potential waste stream and reduce capital costs. There is a low technical risk for this synergy, however, the economic risk, particularly in regards to the water, can be high. The economic costs include the costs of treating the water to meet the locally applicable environmental standards. This option may require expensive chemicals and treatment facilities. EECP Phase II included tests conducted to confirm the viability of integrating F-T water in the slurry feed for the gasifier. Testing conducted at ChevronTexaco's Montebello Technology Center (MTC) included preparing slurries made using petroleum coke with F-T water collected at the LaPorte Alternative Fuels Development Unit (AFDU). The work included bench scale tests to determine the slurry ability of the petroleum coke and F-T water. The results of the tests show that F-T water does not adversely affect slurries for the gasifier. There are a few cases where in fact the addition of F-T water caused favorable changes in viscosity of the slurries. This RD&T task was executed in Phase II and results are reported herein.

  6. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    John Anderson; Mark Anselmo; Earl Berry; Mark Bohn; Ming He; Charles H. Schrader; Lalit Shah; Donald Todd; Robert Schavey

    2004-01-12T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to its detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC (TES) (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR). The work was under cooperative agreements with the U.S. Department of Energy (DOE). TES is providing the gasification technology and the Fischer-Tropsch (F-T) technology developed by Rentech Inc., GE is providing the combustion turbine technology, Praxair is providing the air separation technology, and KBR is providing overall engineering. Each of the EECP's subsystems was assessed for technical risks and barriers in Phase I. A plan was identified to mitigate the identified risks (Phase II RD&T Plan, October 2000). The RD&T Plan identified catalyst/wax separation as a potential technical and economic risk. To mitigate risks to the proposed EECP concept, Phase II RD&T included tests for secondary catalyst/wax separation systems as part of Task 2.3--Catalyst/Wax Separation. The LCI Scepter{reg_sign} Microfiltration system was determined to be best suited for producing a filtrate that met the EECP secondary catalyst/wax separation standards of producing F-T wax containing less than10 ppmw solids. As part of task 2.3, micro-filtration removal efficiencies and production rates for two FT feeds, Rentech Inc. bubble column reactor (BCR) product and LaPorte Alternative Fuels Development Unit (AFDU) product, were evaluated. Based on comparisons between the performances of these two materials, the more readily available LaPorte AFDU material was judged an acceptable analog to the BCR material that would be produced in a larger-scale F-T synthesis. The present test was initiated to obtain data in an extended range of concentration for use in the scale-up design of the secondary catalyst/wax separation system that would be operating at the EECP capacity.

  7. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Charles Benham; Mark Bohn; John Anderson; Earl Berry; Fred Brent; Ming He; Randy Roberts; Lalit Shah; Marjan Roos

    2003-09-15T23:59:59.000Z

    The 1999 U. S. Department of Energy (DOE) award to Texaco Energy Systems Inc. (presently Texaco Energy Systems LLC, a subsidiary of ChevronTexaco) was made to provide a Preliminary Engineering Design of an Early Entrance Coproduction Plant (EECP). Since the award presentation, work has been undertaken to achieve an economical concept design that makes strides toward the DOE Vision 21 goal. The objective of the EECP is to convert coal and/or petroleum coke to electric power plus transportation fuels, chemicals and useful utilities such as steam. The use of petroleum coke was added as a fuel to reduce the cost of feedstock and also to increase the probability of commercial implementation of the EECP concept. This objective has been pursued in a three phase effort through the partnership of the DOE with prime contractor Texaco Energy Systems LLC and subcontractors General Electric (GE), Praxair, and Kellogg Brown and Root (KBR). ChevronTexaco is providing gasification technology and Rentech's Fischer-Tropsch technology that has been developed for non-natural gas feed sources. GE is providing gas turbine technology for the combustion of low energy content gas. Praxair is providing air separation technology, and KBR is providing engineering to integrate the facility. The objective of Phase I was to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. Phase I Preliminary Concept Report was completed in 2000. The Phase I Preliminary Concept Report was prepared based on making assumptions for the basis of design for various technologies that are part of the EECP concept. The Phase I Preliminary Concept Report was approved by the DOE in May 2001. The Phase I work identified technical and economic risks and critical research, development, and testing that would improve the probability of the technical and economic success of the EECP. The Project Management Plan (Task 1) for Phase II was approved by the DOE in 2001. The results of RD&T efforts for Phase II are expected to improve the quality of assumptions made in Phase I for basis of design for the EECP concept. The RD&T work plan (Task 2 and 3) for Phase II has been completed. As the RD&T work conducted during Phase II concluded, it became evident that sufficient, but not necessarily complete, technical information and data would be available to begin Phase III - Basic Engineering Design. Also due to the merger of Chevron and Texaco, the proposed refinery site for the EECP was not available. It became apparent that some additional technical development work would be needed to correctly apply the technology at a specific site. The objective of Task 4 of Phase II is to update the concept basis of design produced during Phase I. As part of this task, items that will require design basis changes and are not site dependent have been identified. The team has qualitatively identified the efforts to incorporate the impacts of changes on EECP concept. The design basis has been modified to incorporate those changes. The design basis changes for those components of EECP that are site and feedstock dependent will be done as part of Phase III, once the site has been selected.

  8. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    John Anderson; Mark Anselmo; Earl Berry; Mark Bohn; Roko Bujas; Ming He; Ken Kwik; Charles H. Schrader; Lalit Shah; Dennis Slater; Donald Todd; Don Wall

    2003-08-21T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC (TES), a subsidiary of ChevronTexaco, General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, Inc. GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems were assessed for technical risks and barriers. A plan was identified to mitigate the identified risks (Phase II RD&T Plan, October 2000). The RD&T Plan identified catalyst/wax separation as a potential technical and economic risk. To mitigate risks to the proposed EECP, Phase II RD&T included tests of an alternative (to Rentech's Dynamic Settler) primary catalyst/wax separation device and secondary catalyst/wax separation systems. The team evaluated multiple technologies for both primary and secondary catalyst/wax separation. Based on successful testing at Rentech (outside of DOE funding) and difficulties in finalizing a contract to demonstrate alternative primary catalyst/wax separation technology (using magnetic separation technology), ChevronTexaco has selected the Rentech Dynamic Settler for primary catalyst/wax separation. Testing has shown the Dynamic Settler is capable of producing filtrate exceeding the proposed EECP primary catalyst/wax separation goal of less than 0.1 wt%. The LCI Scepter{reg_sign} Microfiltration system appeared to be best suited for producing a filtrate that met the EECP secondary catalyst/wax separation standards of 10 parts per million (weight) [ppmw]. The other technologies, magnetic separation and electrostatic separation, were promising and able to reduce the solids concentrations in the filtrate. Additional RD&T will be needed for magnetic separation and electrostatic separation technologies to obtain 10 ppmw filtrate required for the proposed EECP. The Phase II testing reduces the technical and economic risks and provides the information necessary to proceed with the development of an engineering design for the EECP Fischer-Tropsch catalyst/wax separation system.

  9. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Randy Roberts

    2003-04-25T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using petroleum coke and ChevronTexaco's proprietary gasification technology. The objective of Phase I was to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC. (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). ChevronTexaco is providing gasification technology and Fischer-Tropsch technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology and KBR is providing engineering. Each of the EECP subsystems were assessed for technical risks and barriers. A plan was identified to mitigate the identified risks (Phase II RD&T Plan, October 2000). The RD&T Plan identified F-T reactor scale-up as a potential technical risk. The objective of Task 2.3 was to confirm engineering models that allow scale-up to commercial slurry phase bubble column (SPBC) reactors operating in the churn-turbulent flow regime. In developmental work outside the scope of this project, historical data, literature references, and a scale-up from a 1 1/2-in. (3.8 cm) to 6-ft (1.8 m) SPBC reactor have been reviewed. This review formed the background for developing scale-up models for a SPBC reactor operating in the churn-turbulent flow regime. The necessary fundamental physical parameters have been measured and incorporated into the mathematical catalyst/kinetic model developed from the SPBC and CSTR work outside the scope of this EECP project. The mathematical catalyst/kinetic model was used to compare to experimental data obtained at Rentech during the EECP Fischer-Tropsch Confirmation Run (Task 2.1; reported separately). The prediction of carbon monoxide (CO) conversion as a function of days on stream compares quite closely to the experimental data.

  10. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    John H. Anderson; Charles Benham; Earl R. Berry; Ming He; Charles H. Schrader; Lalit S. Shah; O.O. Omatete; T.D. Burchell

    2004-01-12T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. During Phase I the team identified several potential methods to reduce or minimize the environmental impact of the proposed EECP. The EECP Project Team identified F-T catalyst disposal, beneficial gasifier slag usage (other than landfill), and carbon dioxide recovery for the gas turbine exhaust for study under this task. Successfully completing the Task 2.10 RD&T provides additional opportunities for the EECP to meet the goals of DOE's Vision 21 Program. The gasification section offers several opportunities to maximize the environmental benefits of an EECP. The spent F-T catalyst can be sent to landfills or to the gasification section. Testing in Phase II shows that the spent F-T catalyst with a small wax coating can safely meet federal landfill requirements. As an alternative to landfilling, it has been proposed to mix the spent F-T catalyst with the petroleum coke and feed this mixture to the gasification unit. Based on ChevronTexaco's experience with gasification and the characteristics of the spent F-T catalyst this appears to be an excellent opportunity to reduce one potential waste stream. The slag from the gasification unit can be commercially marketed for construction or fuel (such as cement kiln fuel) uses. The technical and economic benefits of these options must be reviewed for the final EECP before incorporating a specific alternative into the design basis. Reducing greenhouse gas emissions, particularly carbon dioxide, is an important goal of the EECP. The Texaco gasification process provides opportunities to capture high purity streams of carbon dioxide. For Phase II, a carbon fiber composite molecular sieve (CFCMS) was tested to determine its potential to remove high purity carbon dioxide from the exhaust of a gas turbine. Testing on with a simulated gas turbine exhaust shows that the CFCMS is able to remove high purity carbon dioxide from the exhaust. However, more development is required to optimize the system.

  11. J Bone Miner Res . Author manuscript Fracture risk prediction using BMD and clinical risk factors in early

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    ,651 peri- and early post-menopausal women (mean age (± SD): 54 4 yr) with a mean follow-up period of 13 Density ; Female ; Fractures, Bone ; etiology ; Humans ; Middle Aged ; Osteoporosis, Postmenopausal definition of osteoporosis ( ), i.e. a bone mineral density (BMD) value less than 2.5 standard deviations

  12. Market Transformation: Fuel Cell Early Adoption (Presentation...

    Office of Environmental Management (EM)

    Transformation: Fuel Cell Early Adoption (Presentation) Market Transformation: Fuel Cell Early Adoption (Presentation) Presented at the DOE Fuel Cell Pre-Solicitation Workshop held...

  13. Age characteristics in a multidecadal Arctic sea ice simulation

    SciTech Connect (OSTI)

    Hunke, Elizabeth C [Los Alamos National Laboratory; Bitz, Cecllia M [UNIV. OF WASHINGTON

    2008-01-01T23:59:59.000Z

    Results from adding a tracer for age of sea ice to a sophisticated sea ice model that is widely used for climate studies are presented. The consistent simulation of ice age, dynamics, and thermodynamics in the model shows explicitly that the loss of Arctic perennial ice has accelerated in the past three decades, as has been seen in satellite-derived observations. Our model shows that the September ice age average across the Northern Hemisphere varies from about 5 to 8 years, and the ice is much younger (about 2--3 years) in late winter because of the expansion of first-year ice. We find seasonal ice on average comprises about 5% of the total ice area in September, but as much as 1.34 x 10{sup 6} km{sup 2} survives in some years. Our simulated ice age in the late 1980s and early 1990s declined markedly in agreement with other studies. After this period of decline, the ice age began to recover, but in the final years of the simulation very little young ice remains after the melt season, a strong indication that the age of the pack will again decline in the future as older ice classes fail to be replenished. The Arctic ice pack has fluctuated between older and younger ice types over the past 30 years, while ice area, thickness, and volume all declined over the same period, with an apparent acceleration in the last decade.

  14. AGING FACILITY WORKER DOSE ASSESSMENT

    SciTech Connect (OSTI)

    R.L. Thacker

    2005-03-24T23:59:59.000Z

    The purpose of this calculation is to estimate radiation doses received by personnel working in the Aging Facility performing operations to transfer aging casks to the aging pads for thermal and logistical management, stage empty aging casks, and retrieve aging casks from the aging pads for further processing in other site facilities. Doses received by workers due to aging cask surveillance and maintenance operations are also included. The specific scope of work contained in this calculation covers both collective doses and individual worker group doses on an annual basis, and includes the contributions due to external and internal radiation from normal operation. There are no Category 1 event sequences associated with the Aging Facility (BSC 2004 [DIRS 167268], Section 7.2.1). The results of this calculation will be used to support the design of the Aging Facility and to provide occupational dose estimates for the License Application. The calculations contained in this document were developed by Environmental and Nuclear Engineering of the Design and Engineering Organization and are intended solely for the use of the Design and Engineering Organization in its work regarding facility operation. Yucca Mountain Project personnel from the Environmental and Nuclear Engineering should be consulted before use of the calculations for purposes other than those stated herein or use by individuals other than authorized personnel in Environmental and Nuclear Engineering.

  15. Blind teen-age students' expectations Focus: school-age

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Blind teen-age students' expectations Focus: school-age Topic: What are the changing demands disabled pupils, inclusion increased significantly, particularly in high schools. Blind learners, who used. For this lecture, I will present a few blind students' opinions, which will help building the items for the case

  16. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Abdalla H. Ali; John H. Anderson; Earl R. Berry; Charles H. Schrader; Lalit S. Shah

    2003-04-16T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which produces at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems were assessed for technical risks and barriers. A plan was identified to mitigate the identified risks (Phase II RD&T Plan, October 2000). The RD&T Plan identified petroleum coke characteristics as a potential technical risk. The composition of petroleum coke varies from one refinery to another. Petroleum coke characteristics are a function of the crude oil slate available at the refinery and the coker operating parameters. The specific petroleum coke characteristics at a refinery affect the design of the Gasification and Acid Gas Removal (AGR) subsystems. Knowing the petroleum coke composition provides the necessary data to proceed to the EECP Phase III engineering design of the gasification process. Based on ChevronTexaco's experience, the EECP team ranked the technical, economic, and overall risks of the petroleum coke composition related to the gasification subsystem as low. In Phase I of the EECP Project, the Motiva Port Arthur Refinery had been identified as the potential EECP site. As a result of the merger between Texaco and Chevron in October 2001, Texaco was required to sell its interest in the Motiva Enterprises LLC joint venture to Shell Oil Company and Saudi Refining Inc. To assess the possible impact of moving the proposed EECP host site to a ChevronTexaco refinery, samples of petroleum coke from two ChevronTexaco refineries were sent to MTC for bench-scale testing. The results of the analysis of these samples were compared to the Phase I EECP Gasification Design Basis developed for Motiva's Port Arthur Refinery. The analysis confirms that if the proposed EECP is moved to a new refinery site, the Phase I EECP Gasification Design Basis would have to be updated. The lower sulfur content of the two samples from the ChevronTexaco refineries indicates that if one of these sites were selected, the Sulfur Recovery Unit (SRU) might be sized smaller than the current EECP design. This would reduce the capital expense of the SRU. Additionally, both ChevronTexaco samples have a higher hydrogen to carbon monoxide ratio than the Motiva Port Arthur petroleum coke. The higher hydrogen to carbon monoxide ratio could give a slightly higher F-T products yield from the F-T Synthesis Reactor. However, the EECP Gasification Design Basis can not be updated until the site for the proposed EECP site is finalized. Until the site is finalized, the feedstock (petroleum coke) characteristics are a low risk to the EECP project.

  17. EARLY ENTRANCE COPRODUCTION PLANT

    SciTech Connect (OSTI)

    Fred D. Brent; Lalit Shah; Earl Berry; Charles H. Schrader; John Anderson; J. Erwin; Matthew G. Banks; Terry L. Ullman

    2004-01-12T23:59:59.000Z

    The overall objective of this project is the three phase development of an Early Entrance Coproduction Plant (EECP) which uses petroleum coke to produce at least one product from at least two of the following three categories: (1) electric power (or heat), (2) fuels, and (3) chemicals using ChevronTexaco's proprietary gasification technology. The objective of Phase I is to determine the feasibility and define the concept for the EECP located at a specific site; develop a Research, Development, and Testing (RD&T) Plan to mitigate technical risks and barriers; and prepare a Preliminary Project Financing Plan. The objective of Phase II is to implement the work as outlined in the Phase I RD&T Plan to enhance the development and commercial acceptance of coproduction technology. The objective of Phase III is to develop an engineering design package and a financing and testing plan for an EECP located at a specific site. The project's intended result is to provide the necessary technical, economic, and environmental information needed by industry to move the EECP forward to detailed design, construction, and operation. The partners in this project are Texaco Energy Systems LLC or TES (a subsidiary of ChevronTexaco), General Electric (GE), Praxair, and Kellogg Brown & Root (KBR) in addition to the U.S. Department of Energy (DOE). TES is providing gasification technology and Fischer-Tropsch (F-T) technology developed by Rentech, GE is providing combustion turbine technology, Praxair is providing air separation technology, and KBR is providing engineering. Each of the EECP subsystems was assessed for technical risks and barriers. A plan was developed to mitigate the identified risks (Phase II RD&T Plan, October 2000). Phase II RD&T Task 2.6 identified as potential technical risks to the EECP the fuel/engine performance and emissions of the F-T diesel fuel products. Hydrotreating the neat F-T diesel product reduces potentially reactive olefins, oxygenates, and acids levels and alleviates corrosion and fuel stability concerns. Future coproduction plants can maximize valuable transportation diesel by hydrocracking the F-T Synthesis wax product to diesel and naphtha. The upgraded neat F-T diesel, hydrotreater F-T diesel, and hydrocracker F-T diesel products would be final blending components in transportation diesel fuel. Phase II RD&T Task 2.6 successfully carried out fuel lubricity property testing, fuel response to lubricity additives, and hot-start transient emission tests on a neat F-T diesel product, a hydrocracker F-T diesel product, a blend of hydrotreater and hydrocracker F-T diesel products, and a Tier II California Air Resources Board (CARB)-like diesel reference fuel. Only the neat F-T diesel passed lubricity inspection without additive while the remaining three fuel candidates passed with conventional additive treatment. Hot-start transient emission tests were conducted on the four fuels in accordance with the U.S. Environmental Protection Agency (EPA) Federal Test Procedure (FTP) specified in Code of Federal Regulations, Title 40, Part 86, and Subpart N on a rebuilt 1991 Detroit Diesel Corporation Series 60 heavy-duty diesel engine. Neat F-T diesel fuel reduced oxides of nitrogen (NO{sub x}), total particulate (PM), hydrocarbons (HC), carbon monoxide (CO), and the Soluble Organic Fraction (SOF) by 4.5%, 31%, 50%, 29%, and 35%, respectively, compared to the Tier II CARB-like diesel. The hydrocracker F-T diesel product and a blend of hydrocracker and hydrotreater F-T diesel products also reduced NO{sub x}, PM, HC, CO and SOF by 13%, 16% to 17%, 38% to 63%, 17% to 21% and 21% to 39% compared to the Tier II CARB-like diesel. The fuel/engine performance and emissions of the three F-T diesel fuels exceed the performance of a Tier II CARB-like diesel. Phase II RD&T Task 2.6 successfully met the lubricity property testing and F-T diesel fuel hot-start transient emissions test objectives. The results of the testing help mitigate potential economic risks on obtaining a premium price for the F-T diesel fuel

  18. Caribbean Equal Access Program: HIV/AIDS Information Resources from the National Library of Medicine

    SciTech Connect (OSTI)

    Nancy Dancy, NLM, and Wilma Templin-Branner, ORISE

    2009-01-01T23:59:59.000Z

    As the treatment and management of HIV/AIDS continues to evolve with new scientific breakthroughs, treatment discoveries, and management challenges, it is difficult for people living with HIV/AIDS and those who care for them to keep up with the latest information on HIV/AIDS prevention, treatment, and research. The National Library of Medicine, of the National Institutes of Health, has a wealth of health information resources freely available on the Internet to address these needs.

  19. Proteomic Analysis of Saliva in HIV-positive Heroin Addicts Reveals Proteins Correlated with Cognition

    SciTech Connect (OSTI)

    Dominy, Stephen; Brown, Joseph N.; Ryder, Mark I.; Gritsenko, Marina A.; Jacobs, Jon M.; Smith, Richard D.

    2014-04-01T23:59:59.000Z

    The prevalence of HIV-associated neurocognitive disorders (HAND) remains high despite effective antiretroviral therapies. Multiple etiologies have been proposed over the last few years to account for this phenomenon, including the neurotoxic effects of antiretrovirals and co-morbid substance abuse. However, no underlying molecular mechanism has been identified. Emerging evidence in several fields has linked the gut to brain diseases, but the effect of the gut on the brain during HIV infection has not been explored. Saliva is the most accessible gut biofluid, and is therefore of great scientific interest for diagnostic and prognostic purposes. This study presents a longitudinal, liquid chromatography-mass spectrometry-based quantitative proteomics study investigating saliva samples taken from 8 HIV-positive (HIV+) and 11 -negative (HIV-) heroin addicts. In the HIV+ group, 58 proteins were identified that show significant correlations with cognitive scores and that implicate disruption of protein quality control pathways by HIV. Notably, no proteins from the HIV- heroin addict cohort showed significant correlations with cognitive scores. In addition, the majority of correlated proteins have been shown to be associated with exosomes, allowing us to propose that the salivary glands and/or oral epithelium may modulate brain function during HIV infection through the release of discrete packets of proteins in the form of exosomes.

  20. Script generation and multitasking in HIV-1 infection : implications for everyday functioning

    E-Print Network [OSTI]

    Scott, James Cobb

    2009-01-01T23:59:59.000Z

    Gagnon S. (2004). Script generation following frontal andGroup. (2005). Action (verb) generation in HIV-1 infection.Note. SG = Script Generation test; MT = Multitasking test. *

  1. The Exponential Phase of HIV/AIDS Epidemic in Japan

    E-Print Network [OSTI]

    Inaba, Hisashi

    The Exponential Phase of HIV/AIDS Epidemic in Japan Hisashi INABA Institute of Population Problems 2-2, 1-Chome, Kasumigaseki, Chiyoda-ku Tokyo 100-45, Japan F--K"$K$*$1$k#H#I#V!?#A#I#D#S$N;X?t4X incidence in Japan has been growing exponentially. Using our calculation method, we conclude that the number

  2. aging society aging: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 Age CiteSeer Summary: Success in school can be a positive counterweight to the abuse, neglect, separation, and impermanence experienced by the more than 400,000 U.S....

  3. Early English Books on microfilm

    E-Print Network [OSTI]

    search term in one box, or two if you are combining or excluding terms. You can leave the Search Three. In the next search box, enter the words early english books. Leave the other defaults alone. Now access the catalog (libcat.wichita.edu), change the default to Advanced Search: Step Two. Place your

  4. Visualising Early Product Development Information

    E-Print Network [OSTI]

    Salustri, Filippo A.

    screws store energy Electricity Supply Screw User Force couple screw & PSD Installed Screw Waste Energy System Bit Bit Screw Screw Electricity Supply Waste Energy User Force Activation System User Input Architecture Systems Design Design Schematics for visualisation of early product information Light

  5. Cell Senescence: Aging and Cancer

    ScienceCinema (OSTI)

    Campisi, Judith

    2013-05-29T23:59:59.000Z

    Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals.

  6. Malcolm Guite Poets in Age

    E-Print Network [OSTI]

    Robertson, Stephen

    Malcolm Guite Poets in Age or A Study of Reading Habits At first I used to wish that I were Keats passing bell is rung. But now I need the poets who grew old And wore the bottoms of their trousers rolled of pure gold. I need the poets now, who match my age, Like Coleridge I could become a sage, And I bet I

  7. Universal Access to HIV Treatment versus Universal `Test and Treat': Transmission, Drug Resistance & Treatment

    E-Print Network [OSTI]

    Blower, Sally

    Universal Access to HIV Treatment versus Universal `Test and Treat': Transmission, Drug Resistance a universal `test and treat' (T&T) strategy to try to eliminate HIV in SA; treatment reduces infectivity in need or not. This would require treating 5 million individuals almost immediately and providing

  8. Recognition of HIV TAR RNA by triazole linked neomycin dimers Sunil Kumar, Dev P. Arya

    E-Print Network [OSTI]

    Stuart, Steven J.

    protein, (a 86 amino acid protein) and regulates the transcription of HIV virus. TAR RNA­Tat proteinRecognition of HIV TAR RNA by triazole linked neomycin dimers Sunil Kumar, Dev P. Arya Laboratory synthesized using `click chemistry' with varying linker function- ality and length to target the TAR RNA

  9. Solid-State Nuclear Magnetic Resonance Measurements of HIV Fusion Peptide 13

    E-Print Network [OSTI]

    Weliky, David

    Solid-State Nuclear Magnetic Resonance Measurements of HIV Fusion Peptide 13 CO to Lipid 31 P ABSTRACT: Fusion of the human immunodeficiency virus (HIV) membrane and the host cell membrane is an initial step of infection of the host cell. Fusion is catalyzed by gp41, which is an integral membrane

  10. A Cellular Automata Model of the Spread of HIV in a Community of Injection Drug Users

    E-Print Network [OSTI]

    A Cellular Automata Model of the Spread of HIV in a Community of Injection Drug Users Vahid (CSMG), The IRMACS Centre Simon Fraser University Background Intravenous drug users (IDU) sharing needles for injecting illicit drugs are highly vulnerable to HIV infection because transmission

  11. Computational structure-based methods to anticipate HIV drug resistance evolution and accelerate inhibitor discovery

    E-Print Network [OSTI]

    Chang, Max W.

    2008-01-01T23:59:59.000Z

    energy results from large-scale virtual screening identi?es representative wild-wild-type structure, speci?c amino acid substitutions are modeled, followed by energywild?type HIV?1 mutant HIV?2 Ligand Protease Figure 6.2: Speci?c energy

  12. 5Social Construction of Gender and Sexuality in Online HIV/AIDS Information

    E-Print Network [OSTI]

    Kvasny, Lynette

    /WHO, 2004), women now make up nearly half of all people living with HIV worldwide. In the United States closer at HIV and AIDS infections among women in the United States, Anderson and Smith (2004) report Pennsylvania State University, USA Lynette Kvasny Pennsylvania State University, USA Copyright © 2006, Idea

  13. Houses for early weaned piglets : influence of rearing on the floor or in batteries,

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Houses for early weaned piglets : influence of rearing on the floor or in batteries, temperature groups in order to determine the influence of rearing conditions (housing, room temperature) and feeding on the animals performances between weaning at 36 ± 3 days and 70 days of age. Housing characteristics were

  14. THE AGE OF PLASTIC INGENUITY + RESPONSIBILITY

    E-Print Network [OSTI]

    Mathis, Wayne N.

    THE AGE OF PLASTIC INGENUITY + RESPONSIBILITY An Interdisciplinary Symposium Stone Age, Bronze Age, Iron Age...and now the Age of Plastic. The Smithsonian Institution is leveraging its collections--arguably the world's greatest repository of plastic material culture--to investigate the significance of plastic, its

  15. WHOLE-ROCK 87Sr/86Sr COMPOSITION AND APPARENT STRONTIUM ISOTOPIC AGE OF LIMESTONES FROM SITE 1118, WOODLARK RIFT BASIN, SOUTHWEST PACIFIC (OCEAN DRILLING PROGRAM LEG 180) 

    E-Print Network [OSTI]

    Allan, Tony; Robertson, Alastair H F; Sharp, Timothy R; Trotter, Julie

    2001-01-01T23:59:59.000Z

    Limestone from Unit VI (857.1–859.15 meters below seafloor) collected at Site 1118 contains a planktonic foraminiferal fauna indicating a latest Miocene to early Pliocene age. Globorotalia tumida is recorded in Sample ...

  16. Cross gender-age trabecular texture analysis in cone beam computed tomography

    E-Print Network [OSTI]

    Ling, Haibin

    osteoporosis screening tools in the jaws. Keywords: cone-beam computed tomography, osteoporosis, radiology, osteoporosis afflicts 55% of Americans aged 50 and above.1 Early diagnosis of osteoporosis is very important to prevent more serious complications such as hip fracture. The current gold standard for osteoporosis

  17. Multipath Probabilistic Early Response TCP

    E-Print Network [OSTI]

    Singh, Ankit

    2012-10-19T23:59:59.000Z

    : Chair of Committee, A. L. Narasimha Reddy Committee Members, Riccardo Bettati Srinivas Shakottai Head of Department, Costas N. Georghiades August 2012 Major Subject: Computer Engineering iii ABSTRACT Multipath Probabilistic Early Response TCP.... (August 2012) Ankit Singh, B.Tech., Indian Institute of Technology, Guwahati Chair of Advisory Committee: Dr. A. L. Narasimha Reddy Many computers and devices such as smart phones, laptops and tablet devices are now equipped with multiple network...

  18. Early Exercise Option Valuation 00000001111111

    E-Print Network [OSTI]

    Oosterlee, Cornelis W. "Kees"

    Early Exercise Option Valuation 0 0 1 1 00000001111111 s T 0 0s K Mm+1m t 0 With V (tM , S(tM)) = E. Computational Finance (Summerschool) Hitotsubashi University August 2009 2 / 51 #12;The CONV method (Carr-Madan extended) The main premise of the CONV method is that f (y|x) depends on x and y via f (y|x) = f (y - x

  19. Physical Activity, Sedentary Time and Physical Capability in Early Old Age: British Birth Cohort Study

    E-Print Network [OSTI]

    Cooper, Andrew J. M.; Simmons, Rebecca K.; Kuh, Diana; Brage, Soren; Cooper, Rachel; NSHD scientific and data collection team

    2015-05-11T23:59:59.000Z

    . Wellcome Trust Clinical Research Facility, Manchester, UK 11. Department of Clinical Radiology, Central Manchester University Hospitals NHS Founda- tion Trust, Manchester, UK 12. The Manchester Heart Centre, Central Manchester University Hospitals NHS... to be alive and who had a known address in En- gland, Scotland or Wales) were invited for an assessment at one of six clinical research facilities (CRFs) or to be visited by a research nurse at home. Invitations were not sent to those who had died (n = 778...

  20. EARLY-AGE CONCRETE STRENGTH ESTIMATION TECHNIQUE USING EMBEDDED PIEZOELECTRIC SELF-SENSING IMPEDANCE

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    -746 shparkpc@skku.edu ABSTRACT Recently, demands for the construction of Nuclear Power Plants (NPP) using high strength concrete (HSC) with a low W/C ratio and high compressive strength for construction NPP structures if the curing process is inadequate. To prevent unexpected collapse during and after the construction of HSC

  1. A review of "Early Modern French Thought: The Age of Suspicion." by Michael Moriarty 

    E-Print Network [OSTI]

    Todd Janke

    2006-01-01T23:59:59.000Z

    to scrutinize the taken-for-granted of everyday experience? (6). Moriarty also attempts to determine how their outlook of suspicion towards the quotidian is informed by commitment to belief in a transcendent God. Chapter two provides a brief, but effective...

  2. Mechanisms of Mating-Behavior Deterioration in Early Aging Male C. elegans 

    E-Print Network [OSTI]

    Guo, Xiaoyan

    2014-08-06T23:59:59.000Z

    . This is consistent with the observation that old males exhibit reduced control over their ability to mate. Caloric restriction is an efficient non-genetic intervention to increase lifespan. I demonstrated here that it also improves mating behavior in 3-day-old males...

  3. FACULTY EARLY RETIREMENT PROGRAM Request Form

    E-Print Network [OSTI]

    de Lijser, Peter

    FACULTY EARLY RETIREMENT PROGRAM Request Form INSTRUCTIONS: This form is to be used by faculty to request participation in the Faculty Early Retirement Program (FERP) or to request a change in FERP status

  4. Recommendation 177: Facilitating Early Public Input

    Broader source: Energy.gov [DOE]

    DOE should initiate consultation meetings with stake holders immediately to allow early public input into the planning for IFDP

  5. Transportation, Aging and Disposal Canister System Performance...

    Broader source: Energy.gov (indexed) [DOE]

    This document provides specifications for selected system components of the Transportation, Aging and Disposal (TAD) canister-based system. Transportation, Aging and Disposal...

  6. Monitoring and Early Warning for Internet Worms

    E-Print Network [OSTI]

    Xu, Shouhuai

    an effective early warning system. Based on epidemic models and observation data of a fast-spreading worm, we a worm monitoring and early warning system. In addition, by collecting more complete data on the worm1 Monitoring and Early Warning for Internet Worms Cliff C. Zou, Lixin Gao, Weibo Gong, Don Towsley

  7. Monitoring and Early Warning for Internet Worms

    E-Print Network [OSTI]

    Shenoy, Prashant

    monitoring and early warning system. In this paper, we propose effective algorithms for early detectionMonitoring and Early Warning for Internet Worms Cliff Changchun Zou, Lixin Gao, Weibo Gong, Don warning system. In order to detect an unknown (zero-day) worm, a straight- forward way is to use various

  8. Monitoring and Early Warning for Internet Worms

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    of these worms calls for a worm monitoring and early warning system. In this paper we propose the effective algorithms for early warning of the presence of a worm and the correspondent monitoring system. Based1 Monitoring and Early Warning for Internet Worms Cliff C. Zou, Lixin Gao, Weibo Gong, Don Towsley

  9. Equal Access Initiative HIV/AIDS Information Resources from NLM

    SciTech Connect (OSTI)

    Templin-Branner W. and N. Dancy

    2010-09-11T23:59:59.000Z

    The Equal Access Initiative: HIV/AIDS Information Resources from the National Library of Medicine training is designed specifically for the National Minority AIDS Council 2010 Equal Access Initiative (EAI) Computer Grants Program awardees to provide valuable health information resources from the National Library of Medicine and other reliable sources to increase awareness of the wealth of treatment information and educational materials that are available on the Internet and to improve prevention and treatment education for their clients. These resources will also meet the needs of community-based

  10. HIV immunity study could pave way for vaccine development

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm) Harmonic Engine GyroSolé(tm)HDFViewhighlights/HeavyHIV

  11. HIV virus spread and evolution studied through computer modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm) Harmonic EngineHIV and evolution studied through computer

  12. Early detection of contagious diseases

    DOE Patents [OSTI]

    Colston, Jr., Billy W. (San Ramon, CA); Milanovich, Fred P. (Lafayette, CA); Estacio, Pedro (Mission San Jose, CA); Chang, John (Walnut Creek, CA)

    2011-08-09T23:59:59.000Z

    This invention provides an electronic proximity apparatus and a surveillance method using such an apparatus for alerting individuals that are exposed to a contagious disease. When a person becomes symptomatic and is diagnosed as positive for a given contagious agent, individuals that have recently maintained a threshold proximity with respect to an infected individual are notified and advised to seek immediate medial care. Treatment of individuals in the very early phases of infection (pre-symptomatic) significantly reduces contagiousness of the infected population first exposed to the contagious disease, thus preventing spread of the disease throughout the general population.

  13. Miller wins Early Career Award

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHighandSWPA / SPRA / USACE625Data ShowCDevelopment ofMiller wins Early

  14. CASL OLCF Early Science Award

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office511041clothAdvanced Materials Advanced. C o w l i t z C o . C l a r k C o . CL2 MilestoneOLCF Early

  15. Fixing famine : the politics of information in famine early warning

    E-Print Network [OSTI]

    Burg, Suzanne M. M.

    2008-01-01T23:59:59.000Z

    and Preparedness Commission Early Warning System. (1998).Ethiopia Early Warning System May/June monthly report. AddisPreparedness Commission Early Warning System. (2004, March).

  16. Hickam Air Force Base Fuel Cell Vehicles: Early Implementation...

    Broader source: Energy.gov (indexed) [DOE]

    Hickam Air Force Base Fuel Cell Vehicles: Early Implementation Experience Hickam Air Force Base Fuel Cell Vehicles: Early Implementation Experience This report sumarizes early...

  17. The interaction of RNA helicase DDX3 with HIV-1 Rev-CRM1-RanGTP complex during the HIV replication cycle

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mahboobi, Seyed Hanif; Javanpour, Alex A.; Mofrad, Mohammad R. K.

    2015-02-27T23:59:59.000Z

    Molecular traffic between the nucleus and the cytoplasm is regulated by the nuclear pore complex (NPC), which acts as a highly selective channel perforating the nuclear envelope in eukaryotic cells. The human immunodeficiency virus (HIV) exploits the nucleocytoplasmic pathway to export its RNA transcripts across the NPC to the cytoplasm. Despite extensive study on the HIV life cycle and the many drugs developed to target this cycle, no current drugs have been successful in targeting the critical process of viral nuclear export, even though HIV’s reliance on a single host protein, CRM1, to export its unspliced and partially spliced RNAmore »transcripts makes it a tempting target. Due to recent findings implicating a DEAD-box helicase, DDX3, in HIV replication and a member of the export complex, it has become an appealing target for anti-HIV drug inhibition. In the present research, we have applied a hybrid computational protocol to analyze protein-protein interactions in the HIV mRNA export cycle. This method is based on molecular docking followed by molecular dynamics simulation and accompanied by approximate free energy calculation (MM/GBSA), computational alanine scanning, clustering, and evolutionary analysis. We highlight here some of the most likely binding modes and interfacial residues between DDX3 and CRM1 both in the absence and presence of RanGTP. This work shows that although DDX3 can bind to free CRM1, addition of RanGTP leads to more concentrated distribution of binding modes and stronger binding between CRM1 and RanGTP.« less

  18. June 17, 2013 Symposium on Aging

    E-Print Network [OSTI]

    Church, George M.

    to forestall and treat diseases of aging such as diabetes, cancer, Alzheimer's and heart disease. Today

  19. advanced grandparental age: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    In most animals, advancing age is accompanied by the deteriorative process of aging (senescence). Aging is the main cause of severe illness and death in humans aging is...

  20. advancing paternal age: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    In most animals, advancing age is accompanied by the deteriorative process of aging (senescence). Aging is the main cause of severe illness and death in humans aging is...

  1. advanced paternal age: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    In most animals, advancing age is accompanied by the deteriorative process of aging (senescence). Aging is the main cause of severe illness and death in humans aging is...

  2. Chelation: A Fundamental Mechanism of Action of AGE Inhibitors...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications. Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE...

  3. Welding tritium aged stainless steel

    SciTech Connect (OSTI)

    Kanne, W.R. Jr.

    1993-04-01T23:59:59.000Z

    Stainless steels exposed to tritium become unweldable by conventional methods due to He buildup within the metal matrix. With longer service lives expected for new weapon systems, and service life extensions of older systems, methods for welding/repair on tritium-exposed material will become important. Results are reported that indicate that both solid-state resistance welding and low-heat gas metal arc overlay welding are promising methods for repair or modification of tritium-aged stainless steel.

  4. AEO Early Release 2013 - oil

    U.S. Energy Information Administration (EIA) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTownDells, Wisconsin:Deployment ActivitiesAge Refining Air1, 2015ResidentialGrowing

  5. AEO2012 Early Release Overview

    U.S. Energy Information Administration (EIA) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTownDells, Wisconsin:Deployment ActivitiesAge Refining Air1,D O E / E I A - 0 4 8 4

  6. 58 International Family Planning Perspectives The number of HIV infections in central and eastern Eu-

    E-Print Network [OSTI]

    ­29.11 Unfortunately, little research exists on the sexu- al risk-taking behavior of Croatian young people. A 1989 of sexual behaviors and HIV/AIDS-related knowl- edge and attitudes among Croatian young adults. Using data

  7. HIV/AIDS risk behaviors and correlates of injection drug use among drug users in Pakistan.

    E-Print Network [OSTI]

    2003-01-01T23:59:59.000Z

    transfusion risks in Karachi, Pakistan. Int J Infect Dis.dis- orders in Pakistan. AIDS Res Hum Retroviruses. 1988;4:threat: HIV/AIDS policy in Pakistan. Health Policy Plann.

  8. Economic growth, convergence and the HIV/AIDS epidemic: a cross-country panel data analysis 

    E-Print Network [OSTI]

    Smith, Joel Benjamin Edmund

    2011-07-05T23:59:59.000Z

    This thesis presents an analysis of the dynamic process of economic growth, national welfare and the HIV/AIDS epidemic. An assessment of the methodological designs of applied growth research is undertaken in order to ...

  9. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys

    E-Print Network [OSTI]

    Barouch, Dan H.

    Human immunodeficiency virus type 1 (HIV-1)-specific monoclonal antibodies with extraordinary potency and breadth have recently been described. In humanized mice, combinations of monoclonal antibodies have been shown to ...

  10. Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission

    E-Print Network [OSTI]

    Klasse, Per Johan

    Vaccination and the application of a vaginal microbicide have traditionally been considered independent methods to prevent the sexual transmission of HIV-1 to women. Both techniques can be effective in macaque models, and ...

  11. Regulatory T Cells Expanded from Hiv-1-Infected Individuals Maintain Phenotype, Tcr Repertoire and Suppressive Capacity

    E-Print Network [OSTI]

    Angin, Mathieu

    While modulation of regulatory T cell (Treg) function and adoptive Treg transfer are being explored as therapeutic modalities in the context of autoimmune diseases, transplantation and cancer, their role in HIV-1 pathogenesis ...

  12. Solid-State NMR Studies of HIV-1 Capsid Protein Assemblies. ...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    or conical structures. In this paper, we present a solid-state NMR analysis of the wild-type HIV-1 CA protein, prepared as conical and spherical assemblies that are stable and...

  13. Formal reasoning on qualitative models of coinfection of HIV and Tuberculosis and HAART therapy

    E-Print Network [OSTI]

    2010-01-18T23:59:59.000Z

    , on the boundaries of bioinformatics, computational and systems biology. Results We present a simplified formalisation of the highly dynamic system consisting of HIV, TB and related therapies, at the cellular level. The progression of the disease (AIDS) depends hence...

  14. EARLY EVOLUTION OF PRESTELLAR CORES

    SciTech Connect (OSTI)

    Horedt, G. P., E-mail: g.horedt@online.de [Kronwinkler 50, D-81245, Munich (Germany)

    2013-08-20T23:59:59.000Z

    Prestellar cores are approximated by singular polytropic spheres. Their early evolution is studied analytically with a Bondi-like scheme. The considered approximation is meaningful for polytropic exponents {gamma} between 0 and 6/5, implying radial power-law density profiles between r {sup -1} and r {sup -2.5}. Gravitationally unstable Jeans and Bonnor-Ebert masses differ at most by a factor of 3.25. Tidally stable prestellar cores must have a mean density contrast {approx}> 8 with respect to the external parent cloud medium. The mass-accretion rate relates to the cube of equivalent sound speed, as in Shu's seminal paper. The prestellar masses accreted over 10{sup 5} years cover the whole stellar mass spectrum; they are derived in simple closed form, depending only on the polytropic equation of state. The stellar masses that can be formed via strict conservation of angular momentum are at most of the order of a brown dwarf.

  15. Early dynamics of transversally thermalized matter

    E-Print Network [OSTI]

    A. Bialas; M. Chojnacki; W. Florkowski

    2008-04-28T23:59:59.000Z

    We argue that the idea that the parton system created in relativistic heavy-ion collisions is formed in a state with transverse momenta close to thermodynamic equilibrium and its subsequent dynamics at early times is dominated by pure transverse hydrodynamics of the perfect fluid is compatible with the data collected at RHIC. This scenario of early parton dynamics may help to solve the problem of early equilibration.

  16. Sandia National Laboratories: control early combustion stages

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    control early combustion stages Direct Measurement of Key Molecule Will Increase Accuracy of Combustion Models On March 3, 2015, in Computational Modeling & Simulation, CRF,...

  17. Nanostructured Optical Photonic Crystal Biosensor for HIV Viral Load Measurement

    E-Print Network [OSTI]

    Shafiee, Hadi

    Detecting and quantifying biomarkers and viruses in biological samples have broad applications in early disease diagnosis and treatment monitoring. We have demonstrated a label-free optical sensing mechanism using ...

  18. Aging phenomena in polystyrene thin films

    E-Print Network [OSTI]

    Koji Fukao; Hiroki Koizumi

    2008-01-05T23:59:59.000Z

    The aging behavior is investigated for thin films of atactic polystyrene through measurements of complex electric capacitance. During isothermal aging process the real part of the electric capacitance increases with aging time, while the imaginary part decreases with aging time. This result suggests that the aging time dependence of the real and imaginary parts are mainly associated with change in thickness and dielectric permittivity, respectively. In thin films, the thickness depends on thermal history of aging even above the glass transition. Memory and `rejuvenation' effects are also observed in the thin films.

  19. Aging of Pentaerythritol Tetranitrate (PETN)

    SciTech Connect (OSTI)

    Foltz, M F

    2009-04-22T23:59:59.000Z

    Pentaerythritol tetranitrate (PETN) is a relatively sensitive explosive used in many electroexplosive devices as well as in medicine. Of primary interest to LLNL is its use in items such as exploding bridgewire (EBW) detonators and exploding bridge foil initiators (EFI). In these devices the crystalline powder is pressed into a granular, low-density compact that can be initiated by an exploding wire or foil. The long-term stability of this pressed compact is of interest to weapon stockpile lifetime prediction studies. Key points about potential aging mechanisms can be summarized as follows: (1) There are a number of factors that can contribute to PETN instability. These include particle size, polymorphic phase transitions, crystal structure, impurities, moisture, occlusions, chemical incompatibility and biological (microorganism) action. of these factors the most important for long-term aging of high surface area powders used in detonators appears to be that of particle size growth. (2) There is a great deal of literature on the thermal degradation kinetics of PETN, unfortunately much of it with little bearing on ambient temperature aging during long-term storage. PETN is very stable with respect to thermal decomposition. Low-temperature thermal studies have not revealed evidence of chemical degradation products in archived PETN. Data extrapolated to 30 C predicts a half-life of 12 million years. (3) Moisture seems to lower the activation energy for and accelerate the decomposition of PETN. (4) External drivers affecting stability include temperature, moisture, radiation fields, and stress, while internal drivers include residual solvents, and impurities. Temperature affects kinetic processes of crystal growth such as adsorption, desorption, and diffusion rates of molecules on the surface of PETN crystals. A low-level radiation field may induce unexpected changes in the chemical makeup of PETN and its homologue impurities. Stress at high pressure points caused by crystalline surface irregularities may cause a decrease in surface area over time due to smoothing of contact points and sintering. PETN has been found to contain a number of impurities, including homologues, pentaerythryl ethers with a mixture of hydroxyl and nitrate functional groups, and organic salts, that can alter its physical and chemical properties. (5) The processes of sublimation/recrystallization and surface diffusion are important processes that can cause changes in PETN crystal morphology, particle size distribution and specific surface area. Sublimation feeds a process called Ostwald ripening, which involves the spontaneous growth of larger crystals from those of smaller size. This process proceeds with age regardless of storage conditions unless the crystals are treated to retard growth. The coarsening mechanisms include Ostwald ripening, 'sintering', and surface diffusion. The latter has not been experimentally observed, but a molecular modeling approach has attempted to investigate this phenomenon theoretically. (6) Threshold test fire, particle size distribution, specific surface area, thermal analysis, chemical analysis, powder compact specific surface area and density are approaches that have been used in the attempt to assess changes attributable to aging of PETN, with varying results. The biggest problem lies in the aging mechanism itself, which likely influences small changes in morphology, both internal and external, and particle size distribution changes on a scale too small to reliably monitor. Other aspects, such as subtle changes in density profiles within pressed powder compacts, may be beyond the capability of current technology to assess. Crystal growth significant enough to affect the PETN particle size distribution is expected to impact detonator performance. (7) Factors relevant to stabilizing particle size growth include crystal morphology, powder surface area and particle size distribution; crystal density and internal defects; and powder compact density and density gradients.

  20. Affinofile profiling: How efficiency of CD4/CCR5 usage impacts the biological and pathogenic phenotype of HIV

    E-Print Network [OSTI]

    Levine, Alex J.

    phenotype of HIV Kelechi Chikere a , Tom Chou b,c , Paul R. Gorry d,e,f , Benhur Lee a,c,g,n a Department

  1. SNF AGING SYSTEM DESCRIPTION DOCUMENT

    SciTech Connect (OSTI)

    L.L. Swanson

    2005-04-06T23:59:59.000Z

    The purpose of this system description document (SDD) is to establish requirements that drive the design of the spent nuclear fuel (SNF) aging system and associated bases, which will allow the design effort to proceed. This SDD will be revised at strategic points as the design matures. This SDD identifies the requirements and describes the system design, as it currently exists, with emphasis on attributes of the design provided to meet the requirements. This SDD is an engineering tool for design control; accordingly, the primary audience and users are design engineers. This SDD is part of an iterative design process. It leads the design process with regard to the flow down of upper tier requirements onto the system. Knowledge of these requirements is essential in performing the design process. The SDD follows the design with regard to the description of the system. The description provided in the SDD reflects the current results of the design process. Throughout this SDD, the term aging cask applies to vertical site-specific casks and to horizontal aging modules. The term overpack is a vertical site-specific cask that contains a dual-purpose canister (DPC) or a disposable canister. Functional and operational requirements applicable to this system were obtained from ''Project Functional and Operational Requirements'' (F&OR) (Curry 2004 [DIRS 170557]). Other requirements that support the design process were taken from documents such as ''Project Design Criteria Document'' (PDC) (BSC 2004 [DES 171599]), ''Site Fire Hazards Analyses'' (BSC 2005 [DIRS 172174]), and ''Nuclear Safety Design Bases for License Application'' (BSC 2005 [DIRS 171512]). The documents address requirements in the ''Project Requirements Document'' (PRD) (Canori and Leitner 2003 [DIRS 166275]). This SDD includes several appendices. Appendix A is a Glossary; Appendix B is a list of key system charts, diagrams, drawings, lists and additional supporting information; and Appendix C is a list of procedures that will be used to operate the system.

  2. The role of lysine 186 in HIV-1 integrase multimerization

    SciTech Connect (OSTI)

    Berthoux, Lionel [Department of Microbiology, Columbia University, New York (United States); Sebastian, Sarah [Department of Microbiology, Columbia University, New York (United States); Muesing, Mark A. [Aaron Diamond AIDS Research Center, Rockefeller University, New York (United States); Luban, Jeremy [Department of Microbiology, Columbia University, New York (United States) and Department of Medicine, Columbia University, New York (United States) and Institute for Research in Biomedicine, Bellinzona (Switzerland)]. E-mail: luban@irb.unisi.ch

    2007-07-20T23:59:59.000Z

    HIV-1 integrase (IN) catalyzes biochemical reactions required for viral cDNA insertion into host cell chromosomal DNA, an essential step in the HIV-1 replication cycle. In one of these reactions, the two ends of the linear viral cDNA are believed to be simultaneously ligated to chromosomal DNA by a tetrameric form of IN. The structure of the full-length IN tetramer is not known but a model consisting of the N-terminal domain and the catalytic core revealed basic residues 186 to 188 at the interface between the two IN dimers. We found that alteration of these residues, in particular changing IN lysine residue 186 to glutamate (K186Q), impairs IN oligomerization in the yeast two-hybrid system and decreases oligomeric forms of IN within virions. When expressed independently of other viral proteins in human cells, IN-K186Q did not concentrate in the nucleus as did wild-type IN. Co-expression of wild-type IN restored the multimerization defects of IN-K186Q, in both the two-hybrid system and in virions, and also rescued the nuclear targeting defects. Virions bearing IN-K186Q were not infectious in a single cycle of replication but when mixed virions containing two different IN mutants were produced, IN-K186Q was capable of complementing the catalytically inactive mutant IN-D116A. Our biochemical and functional data support the crystallographic model in which IN residue K186 lies at the interface between IN dimers and suggest that tetramerization is important, not only for concerted integration, but also for IN nuclear targeting.

  3. Accelerated Aging of Roofing Surfaces

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The Future of1 AAccelerated aging of roofing surfaces Hugo Destaillats, Ph.D.

  4. Neurobiology of Aging xxx (2006) xxxxxx Age-related changes in brain activation during

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    Neurobiology of Aging xxx (2006) xxx­xxx Age-related changes in brain activation during a delayed. / Neurobiology of Aging xxx (2006) xxx­xxx impairment in several different memory variables [78], including WM [9

  5. Chloride Depletion in Aged Sea Salt Particles

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Chloride Depletion in Aged Sea Salt Particles Chloride Depletion in Aged Sea Salt Particles Print Wednesday, 06 February 2013 00:00 Particles or aerosols can be directly released...

  6. Dark Energy in the Dark Ages

    E-Print Network [OSTI]

    Linder, Eric V.

    2009-01-01T23:59:59.000Z

    LBNL- 61876 Dark Energy in the Dark Ages Eric V. LinderUniversity of California. Dark Energy in the Dark Ages Eric2008) Non-negligible dark energy density at high redshifts

  7. Utah Commission on Aging June 6, 2007

    E-Print Network [OSTI]

    Tipple, Brett

    Institutions Norma Matheson Chair Anne Peterson University of Utah Mayor JoAnn Seghini Midvale City Sara to the Commission for consideration. · Aging SMART: Denise Brooks distributed Aging SMART Sourcebook. Website is up

  8. 3, 221247, 2007 Modelling the Early

    E-Print Network [OSTI]

    Boyer, Edmond

    CPD 3, 221­247, 2007 Modelling the Early Weichselian Eurasian Ice Sheets V. Peyaud et al. Title of the Past Modelling the Early Weichselian Eurasian Ice Sheets: role of ice shelves and influence of ice Weichselian Eurasian Ice Sheets V. Peyaud et al. Title Page Abstract Introduction Conclusions References

  9. Cooperation Enablement for Centralistic Early Warning Systems

    E-Print Network [OSTI]

    Flegel, Ulrich

    Cooperation Enablement for Centralistic Early Warning Systems Ulrich Flegel SAP Research CEC that is considered here is the centralistic malware early warning system developed in the AMSEL project [3 Karlsruhe Vincenz-Prießnitz-Str. 1 76131 Karlsruhe, Germany ulrich.flegel@sap.com Johannes Hoffmann TU

  10. age randomised controlled: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    98504-3144 An age-length key (ALK) is the tra- ditional method for estimating age-stage length samples for relatively costly age determination (age subsamplel. Age...

  11. aged rat erectile: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    98504-3144 An age-length key (ALK) is the tra- ditional method for estimating age-stage length samples for relatively costly age determination (age subsamplel. Age...

  12. age factors: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    98504-3144 An age-length key (ALK) is the tra- ditional method for estimating age-stage length samples for relatively costly age determination (age subsamplel. Age...

  13. aged interleukin-18 deficient: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    98504-3144 An age-length key (ALK) is the tra- ditional method for estimating age-stage length samples for relatively costly age determination (age subsamplel. Age...

  14. age stratigraphic relationships: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    98504-3144 An age-length key (ALK) is the tra- ditional method for estimating age-stage length samples for relatively costly age determination (age subsamplel. Age...

  15. 6, 39453963, 2006 Methanol inside aged

    E-Print Network [OSTI]

    ACPD 6, 3945­3963, 2006 Methanol inside aged tropical biomass burning plumes G. Dufour et al. Title Chemistry and Physics Discussions First space-borne measurements of methanol inside aged tropical biomass. Dufour (gaelle.dufour@lmd.polytechnique.fr) 3945 #12;ACPD 6, 3945­3963, 2006 Methanol inside aged

  16. Overcoming 'Other-ness' : a comparative analysis of transnational activist collective identity formation among World Social Forum activists and HIV/AIDS healthworkers

    E-Print Network [OSTI]

    Kohler, Kristopher Michael; Kohler, Kristopher Michael

    2012-01-01T23:59:59.000Z

    energy or resources to national development increasingly redirect their resources to caring for ?HIV/AIDS Advocates Protest South Africa‘

  17. AGING PERFORMANCE OF MODEL 9975 PACKAGE FLUOROELASTOMER O-RINGS

    SciTech Connect (OSTI)

    Hoffman, E.; Daugherty, W.; Skidmore, E.; Dunn, K.; Fisher, D.

    2011-05-31T23:59:59.000Z

    The influence of temperature and radiation on Viton{reg_sign} GLT and GLT-S fluoroelastomer O-rings is an ongoing research focus at the Savannah River National Laboratory. The O-rings are credited for leaktight containment in the Model 9975 shipping package used for transportation of plutonium-bearing materials. At the Savannah River Site, the Model 9975 packages are being used for interim storage. Primary research efforts have focused on surveillance of O-rings from actual packages, leak testing of seals at bounding aging conditions and the effect of aging temperature on compression stress relaxation behavior, with the goal of service life prediction for long-term storage conditions. Recently, an additional effort to evaluate the effect of aging temperature on the oxidation of the materials has begun. Degradation in the mechanical properties of elastomers is directly related to the oxidation of the polymer. Sensitive measurements of the oxidation rate can be performed in a more timely manner than waiting for a measurable change in mechanical properties, especially at service temperatures. Measuring the oxidation rate therefore provides a means to validate the assumption that the degradation mechanisms(s) do not change from the elevated temperatures used for accelerated aging and the lower service temperatures. Monitoring the amount of oxygen uptake by the material over time at various temperatures can provide increased confidence in lifetime predictions. Preliminary oxygen consumption analysis of a Viton GLT-based fluoroelastomer compound (Parker V0835-75) using an Oxzilla II differential oxygen analyzer in the temperature range of 40-120 C was performed. Early data suggests oxygen consumption rates may level off within the first 100,000 hours (10-12 years) at 40 C and that sharp changes in the degradation mechanism (stress-relaxation) are not expected over the temperature range examined. This is consistent with the known long-term heat aging resistance of fluoroelastomers relative to hydrocarbon-based elastomers, and in absence of antioxidants that may be consumed over time. Additional experimental effort will be undertaken in the short term range within the first 100 hours of thermal aging to capture further details of the oxygen consumption rate.

  18. Effectiveness of a sports-based HIV prevention intervention in the Dominican Republic: a quasi-experimental study

    E-Print Network [OSTI]

    Vermont, University of

    Effectiveness of a sports-based HIV prevention intervention in the Dominican Republic: a quasi, and strenuous efforts to minimize loss-to-follow-up. Keywords: HIV; youth; sport; Dominican Republic; Caribbean living in Haiti and the Dominican Republic (DR) (PAHO, 2007; UNAIDS, 2008). In recent years, national

  19. HIV-1 Modulates the tRNA Pool to Improve Translation Anna van Weringh1,2

    E-Print Network [OSTI]

    Xia, Xuhua

    HIV-1 Modulates the tRNA Pool to Improve Translation Efficiency Anna van Weringh1,2 Manon Ragonnet. Introduction Viruses use the host translational machinery to translate their own mRNA. As a consequence position of HIV-1 genes (Jenkins and Holmes 2003). The A-bias is mediated by the error-prone reverse

  20. Library versus Library Recognition and Inhibition of the HIV-1 Nef Allelome Allison Olszewski and Gregory A. Weiss*,,

    E-Print Network [OSTI]

    Weiss, Gregory A.

    Library versus Library Recognition and Inhibition of the HIV-1 Nef Allelome Allison Olszewski resistance. Targeting HIV Nef with small molecules screened against a combinatorial library of Nef variants studies. We asked whether a library versus library approach could simultaneously uncover structure

  1. Identification of a D-amino acid decapeptide HIV-1 entry inhibitor

    SciTech Connect (OSTI)

    Boggiano, Cesar [Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121 (United States); Jiang Shibo [Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10021 (United States); Lu Hong [Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10021 (United States); Zhao Qian [Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10021 (United States); Liu Shuwen [Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10021 (United States); Binley, James [Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121 (United States); Blondelle, Sylvie E. [Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121 (United States)]. E-mail: sylvieb@burnham.org

    2006-09-08T23:59:59.000Z

    Entry of human immunodeficiency virus type 1 (HIV-1) virion into host cells involves three major steps, each being a potential target for the development of entry inhibitors: gp120 binding to CD4, gp120-CD4 complex interacting with a coreceptor, and gp41 refolding to form a six-helix bundle. Using a D-amino acid decapeptide combinatorial library, we identified peptide DC13 as having potent HIV-1 fusion inhibitory activity, and effectively inhibiting infection by several laboratory-adapted and primary HIV-1 strains. While DC13 did not block binding of gp120 to CD4, nor disrupt the gp41 six-helix bundle formation, it effectively blocked the binding of an anti-CXCR4 monoclonal antibody and chemokine SDF-1{alpha} to CXCR4-expressing cells. However, because R5-using primary viruses were also neutralized, the antiviral activity of DC13 implies additional mode(s) of action. These results suggest that DC13 is a useful HIV-1 coreceptor antagonist for CXCR4 and, due to its biostability and simplicity, may be of value for developing a new class of HIV-1 entry inhibitors.

  2. Expanded breadth of the T-cell response to mosaic HIV-1 envelope DNA vaccination

    SciTech Connect (OSTI)

    Korber, Bette [Los Alamos National Laboratory; Fischer, William [Los Alamos National Laboratory; Wallstrom, Timothy [Los Alamos National Laboratory

    2009-01-01T23:59:59.000Z

    An effective AIDS vaccine must control highly diverse circulating strains of HIV-1. Among HIV -I gene products, the envelope (Env) protein contains variable as well as conserved regions. In this report, an informatic approach to the design of T-cell vaccines directed to HIV -I Env M group global sequences was tested. Synthetic Env antigens were designed to express mosaics that maximize the inclusion of common potential Tcell epitope (PTE) 9-mers and minimize the inclusion of rare epitopes likely to elicit strain-specific responses. DNA vaccines were evaluated using intracellular cytokine staining (ICS) in inbred mice with a standardized panel of highly conserved 15-mer PTE peptides. I, 2 and 3 mosaic sets were developed that increased theoretical epitope coverage. The breadth and magnitude ofT-cell immunity stimulated by these vaccines were compared to natural strain Env's; additional comparisons were performed on mutant Env's, including gpl60 or gpl45 with or without V regions and gp41 deletions. Among them, the 2 or 3 mosaic Env sets elicited the optimal CD4 and CD8 responses. These responses were most evident in CD8 T cells; the 3 mosaic set elicited responses to an average of 8 peptide pools compared to 2 pools for a set of3 natural Env's. Synthetic mosaic HIV -I antigens can therefore induce T-cell responses with expanded breadth and may facilitate the development of effective T -cell-based HIV -1 vaccines.

  3. Bone-derived mesenchymal stromal cells from HIV transgenic mice exhibit altered proliferation, differentiation capacity and paracrine functions along with impaired therapeutic potential in kidney injury

    SciTech Connect (OSTI)

    Cheng, Kang; Rai, Partab; Lan, Xiqian; Plagov, Andrei; Malhotra, Ashwani [Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhassett, NY (United States); Gupta, Sanjeev [Departments of Medicine and Pathology, Marion Bessin Liver Research Center, Diabetes Center, Cancer Center, Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Institute for Clinical and Translational Research, Albert Einstein College of Medicine, Bronx, NY (United States); Singhal, Pravin C., E-mail: psinghal@nshs.edu [Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhassett, NY (United States)

    2013-08-15T23:59:59.000Z

    Mesenchymal stem cells (MSCs) secrete paracrine factors that could be cytoprotective and serve roles in immunoregulation during tissue injury. Although MSCs express HIV receptors, and co-receptors, and are susceptible to HIV infection, whether HIV-1 may affect biological properties of MSCs needs more study. We evaluated cellular proliferation, differentiation and paracrine functions of MSCs isolated from compact bones of healthy control mice and Tg26 HIV-1 transgenic mice. The ability of MSCs to protect against cisplatin toxicity was studied in cultured renal tubular cells as well as in intact mice. We successfully isolated MSCs from healthy mice and Tg26 HIV-1 transgenic mice and found the latter expressed viral Nef, Vpu, NL4-3 and Vif genes. The proliferation and differentiation of Tg26 HIV-1 MSCs was inferior to MSCs from healthy mice. Moreover, transplantation of Tg26 HIV-1 MSCs less effectively improved outcomes compared with healthy MSCs in mice with acute kidney injury. Also, Tg26 HIV-1 MSCs secreted multiple cytokines, but at significantly lower levels than healthy MSCs, which resulted in failure of conditioned medium from these MSCs to protect cultured renal tubular cells from cisplatin toxicity. Therefore, HIV-1 had adverse biological effects on MSCs extending to their proliferation, differentiation, function, and therapeutic potential. These findings will help in advancing mechanistical insight in renal injury and repair in the setting of HIV-1 infection. -- Highlights: •MSCs isolated from HIV mice displayed HIV genes. •MSCs isolated from HIV mice exhibited attenuated growth and paracrine functions. •AKI mice with transplanted HIV-MSC displayed poor outcome. •HIV-1 MSC secreted multiple cytokines but at a lower level.

  4. Paleoenvironmental implications of novel C[sub 30] steranes in Precambrian to Cenozoic age petroleum and bitumen

    SciTech Connect (OSTI)

    McCaffrey, M.A.; Lipton, P.A. (Chevron Petroleum Technology Company, La Habra, CA (United States)); Moldowan, J.M. (Cheveron Petroleum Technology Company, Richmond, CA (United States) Stanford Univ., CA (United States)); Summons, R.E. (Australian Geological Survey Organization, Canberra City (Australia)); Peters, K.E. (Chevron Overseas Petroleum Inc., San Ramon, CA (United States) Mobil Exploration and Producing Technical Center, Dallas, TX (United States)); Jeganathan, A.; Watt, D.S. (Univ. of Kentucky, Lexington, KY (United States))

    1994-01-01T23:59:59.000Z

    Petroleums and bitumens from Early Proterozoic ([approx] 1800 Ma) to Miocene ([approx] 15 Ma) age marine strata contain 24-isopropylcholestanes, a novel group of C[sub 30] steroids. The abundance of these compounds, relative to 24-n-propylcholestanes, varies with source rock age. Late Proterozoic (Vendian) and Early Cambrian oils and/or bitumens from Siberia, the Urals, Oman, Australia, and India have a high ratio of 24-isopropylcholestanes to 24-n-propylcholestanes ([ge] 1), while younger and older samples have a low ratio ([le]0.4). Temporal changes in this parameter may reflect the relative abundance of certain Porifera (sponges) and certain Marine algae through time. Geochemical indicators such as this, which can constrain the source rock age of a migrated oil, are useful in source rock identification during petroleum exploration.

  5. Igneous processes of the early solar system

    E-Print Network [OSTI]

    Singletary, Steven J. (Steven James), 1973-

    2004-01-01T23:59:59.000Z

    Experimental, petrographic and numerical methods are used to explore the igneous evolution of the early solar system. Chapters 1 and 2 detail the results of petrographic and experimental studies of a suite of primitive ...

  6. Haptic holography : an early computational plastic

    E-Print Network [OSTI]

    Plesniak, Wendy J. (Wendy Jean)

    2001-01-01T23:59:59.000Z

    This dissertation introduces haptic holography, a combination of computational modeling and multimodal spatial display, as an early computationalplastic In this work, we combine various holographic displays with a force ...

  7. aged korean adults: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AGING & SOCIETY Engineering Websites Summary: DEPARTMENT OF HEALTH, AGING & SOCIETY Monthly Speaker Series Dr. Ellen B. Ryan DATE TIME ROOM Department of Health, Aging, &...

  8. Characterization of Field-Aged Exhaust Gas Recirculation Cooler...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Field-Aged Exhaust Gas Recirculation Cooler Deposits Characterization of Field-Aged Exhaust Gas Recirculation Cooler Deposits Characterized field-aged exhaust gas recirculation...

  9. Local Land-Use Controls and Aging-Friendliness

    E-Print Network [OSTI]

    Rosenthal, Larry A.

    2009-01-01T23:59:59.000Z

    A. 2001. “Aging and Smart Growth: Building Aging-Sensitivebuilding such product exclusively, or predominantly, because it creates homogenous-age zones, defeats smart-

  10. Earthquake Early Warning and the Physics of Earthquake Rupture

    E-Print Network [OSTI]

    Wurman, Gilead

    2010-01-01T23:59:59.000Z

    Eds. ) Earthquake Early Warning Systems. Springer, pp.21-44.for the Taiwan early warning system, Bull. Seism. Soc. Am.of Earthquake Early Warning systems, especially in rare

  11. Incorporating safety risk in early system architecture trade studies

    E-Print Network [OSTI]

    Dulac, Nicholas

    Ideally, safety should be a part of the early decision making used in conceptual system design. However, effectively evaluating safety risk3 early enough to inform the early trade studies is not possible with current ...

  12. The SuperNova Early Warning System

    E-Print Network [OSTI]

    K. Scholberg

    2008-03-04T23:59:59.000Z

    A core collapse in the Milky Way will produce an enormous burst of neutrinos in detectors world-wide. Such a burst has the potential to provide an early warning of a supernova's appearance. I will describe the nature of the signal, the sensitivity of current detectors, and SNEWS, the SuperNova Early Warning System, a network designed to alert astronomers as soon as possible after the detected neutrino signal.

  13. The SuperNova Early Warning System

    E-Print Network [OSTI]

    Scholberg, K

    2008-01-01T23:59:59.000Z

    A core collapse in the Milky Way will produce an enormous burst of neutrinos in detectors world-wide. Such a burst has the potential to provide an early warning of a supernova's appearance. I will describe the nature of the signal, the sensitivity of current detectors, and SNEWS, the SuperNova Early Warning System, a network designed to alert astronomers as soon as possible after the detected neutrino signal.

  14. Aging behavior and lifetime modeling for polycarbonate

    SciTech Connect (OSTI)

    Kahlen, S. [Polymer Competence Center Leoben GmbH, Roseggerstrasse 12, Leoben 8700 (Austria); Wallner, G.M. [Institute of Materials Science and Testing of Plastics, University of Leoben, Franz-Josef Strasse 18, Leoben 8700 (Austria); Lang, R.W. [Institute for Polymeric Materials and Testing, University of Linz, Altenbergerstrasse 69, Linz 4040 (Austria)

    2010-05-15T23:59:59.000Z

    In this paper, polycarbonate (PC) as a material candidate for solar absorber applications is investigated as to the aging behavior at different temperatures in air and water. The aging conditioning was performed in air in the temperature range from 120 to 140 C and in water between 70 and 95 C. Tensile tests were performed on unaged and aged PC film specimens at ambient temperature using strain-to-break values as a performance indicator for the degree of aging. For PC the effect of aging was found to strongly depend on the aging conditions. Activation energy based lifetime prediction models according to various methods described in the literature were applied. The activation energies and corresponding lifetime predictions for the temperature range from 40 to 60 C in water and from 90 to 110 C in air derived from these models are compared and interpreted as to their practical relevance. (author)

  15. Effects of main-sequence mass loss on the turnoff ages of globular clusters

    SciTech Connect (OSTI)

    Guzik, J.A.

    1989-01-01T23:59:59.000Z

    Willson, Bowen, and Struck-Marcell have proposed that globular cluster main-sequence turnoff ages can be reconciled with the lower ages of the Galaxy and universe deduced from other methods by incorporating an epoch of early main-sequence mass-loss by stars of spectral types A through early-F. The proposed mass loss is pulsation-driven, and facilitated by rapid rotation. This paper presents stellar evolution calculations of Pop. II (Z = 0.001) mass-losing stars of initial mass 0.8 to 1.6 M/sub /circle dot//, with exponentially-decreasing mass loss rates of e-folding times 0.5 to 2.0 Gyr, evolving to a final mass of 0.7 M/sub /circle dot//. The calculations indicate that a globular cluster with apparent turnoff age 18 Gyr could have an actual age as low as /approximately/12 Gyr. Observational implications that may help to verify the hypothesis, e.g. low C/N abundance ratios among red giants following first dredge-up, blue stragglers, red giant deficiencies, and signatures in cluster mass/luminosity functions, are also discussed.25 refs., 4 figs., 3 tabs.

  16. Materials Research in the Information Age

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Materials Research in the Information Age Accelerating Advanced Material Development NERSC Science Gateway a 'Google of Material Properties' October 31, 2011 | Tags: Materials...

  17. Production and Early Preservation of Lipid Biomarkers in Iron...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Production and Early Preservation of Lipid Biomarkers in Iron Hot Springs. Production and Early Preservation of Lipid Biomarkers in Iron Hot Springs. Abstract: The...

  18. HIV/AIDS Information Resources from the National Library of Medicine-STOP

    SciTech Connect (OSTI)

    Templin-Branner, W. and N. Dancy

    2010-06-15T23:59:59.000Z

    The HIV/AIDS Information Resources from the National Library of Medicine training is designed specifically for the UNCFSP HBCU Screening, Testing, Outreach, and Prevention (STOP) HIV/AIDS Program project members to provide valuable health information resources from the National Library of Medicine and other reliable sources to increase awareness of the wealth of treatment information and educational materials that are available on the Internet and to improve prevention and treatment education for their clients. These resources will also meet the needs of community-based organizations

  19. age reconsidering ovarian: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    age-length key to estimate age Environmental Sciences and Ecology Websites Summary: Optimal sampling design for using the age-length key to estimate age composition of a fish...

  20. New age constraints on the Middle Stone Age occupations of Kharga Oasis, Western Desert, Egypt

    E-Print Network [OSTI]

    Asmerom, Yemane

    New age constraints on the Middle Stone Age occupations of Kharga Oasis, Western Desert, Egypt rocks, or tufas, exposed along the flanks of the Libyan Plateau near Kharga Oasis, Western Desert, Egypt

  1. Early Adopter PDC AtEarly Adopter PDC At Washington and LeeWashington and Lee

    E-Print Network [OSTI]

    Stough, Joshua

    Early Adopter ­ PDC AtEarly Adopter ­ PDC At Washington and LeeWashington and Lee Four-year Liberal with and manipulation of collections of stuff.manipulation of collections of stuff. · PDC applications: sorting, recursive treePDC applications: sorting, recursive tree structures, image processing,...structures, image

  2. Neurobiology of Aging 32 (2011) 669679 Age-related trends in saccade characteristics among the elderly

    E-Print Network [OSTI]

    Munoz, Douglas Perry

    2011-01-01T23:59:59.000Z

    Neurobiology of Aging 32 (2011) 669­679 Age-related trends in saccade characteristics among of Psychology, Queen's University, Kingston, Ontario, Canada e CIHR Group in Sensory-Motor Systems, Queen in reaction time also correlated positively with age in both saccade tasks. Voluntary saccade control

  3. Optimal Seismic Network Density for Earthquake Early Warning: A Case

    E-Print Network [OSTI]

    Allen, Richard M.

    . Serdar Kuyuk and Richard M. Allen INTRODUCTION Earthquake Early Warning Systems (EEWS) rapidly detect and the public actively use early warning information is a crucial factor in early warning system design (AktasOptimal Seismic Network Density for Earthquake Early Warning: A Case Study from California by H

  4. Detecting Internet Worms at Early Stage Shigang Chen Sanjay Ranka

    E-Print Network [OSTI]

    Chen, Shigang

    proposes an Internet-worm early warning system that automatically detects concerted scan activities on the responsiveness of this early warning system. Keywords: Enterprise Security Management, Internet Worm, Early and derives possible signatures of worm attacks. Its goal is to issue warning at the early stage of worm

  5. THE INITIAL MASS FUNCTION OF EARLY-TYPE GALAXIES

    SciTech Connect (OSTI)

    Treu, Tommaso; Auger, Matthew W.; Gavazzi, Raphael; Marshall, Philip J. [Department of Physics, University of California, Santa Barbara, CA 93106 (United States); Koopmans, Leon V. E. [Kapteyn Institute, P.O. Box 800, 9700AV Groningen (Netherlands); Bolton, Adam S., E-mail: tt@physics.ucsb.ed, E-mail: mauger@physics.ucsb.ed, E-mail: pjm@physics.ucsb.ed, E-mail: koopmans@astro.rug.n, E-mail: gavazzi@iap.f, E-mail: bolton@ifa.hawaii.ed, E-mail: bolton@physics.utah.ed [Institute for Astronomy, University of Hawai'i, 2680 Woodlawn Dr., Honolulu, HI 96822 (United States)

    2010-02-01T23:59:59.000Z

    We determine an absolute calibration of the initial mass function (IMF) of early-type galaxies, by studying a sample of 56 gravitational lenses identified by the Sloan Lenses ACS Survey. Under the assumption of standard Navarro, Frenk, and White dark matter halos, a combination of lensing, dynamical, and stellar population synthesis models is used to disentangle the stellar and dark matter contribution for each lens. We define an 'IMF mismatch' parameter alphaident toM {sup LD}{sub *,Ein}/M {sup SPS}{sub *,Ein} as the ratio of stellar mass inferred by a joint lensing and dynamical model (M {sup LD}{sub *,Ein}) to the current stellar mass inferred from stellar populations synthesis models (M {sup SPS}{sub *,Ein}). We find that a Salpeter IMF provides stellar masses in agreement with those inferred by lensing and dynamical models ((log alpha) = -0.00 +- 0.03 +- 0.02), while a Chabrier IMF underestimates them ((log alpha) = 0.25 +- 0.03 +- 0.02). A tentative trend is found, in the sense that alpha appears to increase with galaxy velocity dispersion. Taken at face value, this result would imply a non-universal IMF, perhaps dependent on metallicity, age, or abundance ratios of the stellar populations. Alternatively, the observed trend may imply non-universal dark matter halos with inner density slope increasing with velocity dispersion. While the degeneracy between the two interpretations cannot be broken without additional information, the data imply that massive early-type galaxies cannot have both a universal IMF and universal dark matter halos.

  6. POSTER PRESENTATION Open Access HIV-1 Tat protein induces the production of IDO in

    E-Print Network [OSTI]

    Boyer, Edmond

    experiments were performed and showed that: i) at the kinetic level, Tat induced IDO expression before,3 dioxygenase (IDO) expression, and dendritic cells (DC) dysfunction were often associated with AIDS disease from HIV-1 Lai and SF-2 strains on the expression of IDO, in Monocyte-derived dendritic cells (Mo

  7. HIV-1-infected macrophages induce astrogliosis by SDF-1{alpha} and matrix metalloproteinases

    SciTech Connect (OSTI)

    Okamoto, Mika [Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Wang, Xin [Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan); Baba, Masanori [Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544 (Japan)]. E-mail: baba@m.kufm.kagoshima-u.ac.jp

    2005-11-04T23:59:59.000Z

    Brain macrophages/microglia and astrocytes are known to be involved in the pathogenesis of HIV-1-associated dementia (HAD). To clarify their interaction and contribution to the pathogenesis, HIV-1-infected or uninfected macrophages were used as a model of brain macrophages/microglia, and their effects on human astrocytes in vitro were examined. The culture supernatants of HIV-1-infected or uninfected macrophages induced significant astrocyte proliferation, which was annihilated with a neutralizing antibody to stromal cell-derived factor (SDF)-1{alpha} or a matrix metalloproteinase (MMP) inhibitor. In these astrocytes, CXCR4, MMP, and tissue inhibitors of matrix metalloproteinase mRNA expression and SDF-1{alpha} production were significantly up-regulated. The supernatants of infected macrophages were always more effective than those of uninfected cells. Moreover, the enhanced production of SDF-1{alpha} was suppressed by the MMP inhibitor. These results indicate that the activated and HIV-1-infected macrophages can indirectly induce astrocyte proliferation through up-regulating SDF-1{alpha} and MMP production, which implies a mechanism of astrogliosis in HAD.

  8. VPR.A3A CHIMERA INHIBITS HIV REPLICATION Renato S. Aguiar1

    E-Print Network [OSTI]

    Soloveichik, David

    1 VPR.A3A CHIMERA INHIBITS HIV REPLICATION Renato S. Aguiar1 , Nika Lovsin2 , Amilcar Tanuri3. Indeed, the Vpr.A3A chimera but not A3A was found abundantly in the viral core. It also restricted

  9. Extreme Genomics By Scouring the Genomes of 50 HIV-Resistant People, Study

    E-Print Network [OSTI]

    Dolbow, John

    Extreme Genomics By Scouring the Genomes of 50 HIV-Resistant People, Study Takes Aim at Rare Gene Genome Variation, and his colleagues think that the complete genome sequences of those fortunate few against the viral strain that usually infects humans. That's because the CCR5 protein is Extreme Genomics

  10. Tracing the HIV-1 subtype B mobility in Europe: a phylogeographic approach

    SciTech Connect (OSTI)

    Leitner, Thomas [Los Alamos National Laboratory; Paraskevis, D [KATHOLIEKE UNIV; Pybus, O [UNIV OF OXFORD; Magiorkinis, G [KATHOLIEKE UNIV; Hatzakis, A [KATHOLIEKE UNIV

    2008-01-01T23:59:59.000Z

    The prevalence and the origin of HIV-1 subtype B, the most prevalent circulating clade among the long-term residents in Europe, have been studied extensively. However the spatial diffusion of the epidemic from the perspective of the virus has not previously been traced. In the current study we inferred the migration history of HIV-1 subtype B by way of a phylogeography of viral sequences sampled from 16 European countries and Israel. Migration events were inferred from viral phylogenies by character reconstruction using parsimony. With regard to the spatial dispersal of the HIV subtype B sequences across viral phylogenies, in most of the countries in Europe the epidemic was introduced by multiple sources and subsequently spread within local networks. Poland provides an exception where most of the infections were the result of a single point introduction. According to the significant migratory pathways, we show that there are considerable differences across Europe. Specifically, Greece, Portugal, Serbia and Spain, provide sources shedding HIV-1; Austria, Belgium and Luxembourg, on the other hand, are migratory targets, while for Denmark, Germany, Italy, Israel, Norway, the Netherlands, Sweden, Switzerland and the UK we inferred significant bidirectional migration. For Poland no significant migratory pathways were inferred. Subtype B phylogeographies provide a new insight about the geographical distribution of viral lineages, as well as the significant pathways of virus dispersal across Europe, suggesting that intervention strategies should also address tourists, travellers and migrants.

  11. Fatigue-related Gene-Networks identified in CD14+ cells isolated from HIV infected Patients -

    E-Print Network [OSTI]

    Dobra, Adrian

    : Genes including the actin cytoskeletal regulatory proteins prokineticin 2 and cofilin 2 along with mitochondrial inner membrane proteins are involved in multiple pathways and were predictors of fatigue status and between 80-100% of persons living with HIV disease complaint of ongoing lack of energy and exhaustion

  12. Mathematical analysis of delay differential equation models of HIV-1 infection

    E-Print Network [OSTI]

    Bernard, Samuel

    in HIV-1 infected patients, minimal estimates of the death rate of productively infected cells, the rate that when the drug efficacy is less than perfect the estimated value of the loss rate of productively from experiments in which antiret- roviral drugs were given to perturb the dynamical state of infection

  13. Nucleic Acid Conformational Changes Essential for HIV-1 Nucleocapsid Protein-mediated Inhibition of

    E-Print Network [OSTI]

    Levin, Judith G.

    and a TAR-containing acceptor RNA molecule, we find that when both nucleic acids are present, NC facilitatesNucleic Acid Conformational Changes Essential for HIV-1 Nucleocapsid Protein-mediated Inhibition) is a nucleic acid chaperone protein that has been shown to greatly facilitate the nucleic acid rearrangements

  14. Structural properties of the histidine-containing loop in HIV-1RNase H

    SciTech Connect (OSTI)

    Kern, G.; Pelton, J.; Marqusee, S.; Kern, D.

    2001-01-02T23:59:59.000Z

    The isolated HIV-1 RNase H domain is inactive. This inactivity has been linked to the lack of structure in the C-terminus of the isolated domain. His539 residing in a loop preceding the C-terminal Helix was studies by NMR to determine the stability and conformational properties of this region.

  15. DOI: 10.1002/ijch.201100102 Single-Molecule Studies of HIV-1 Protease Catalysis

    E-Print Network [OSTI]

    Myong, Sua

    DOI: 10.1002/ijch.201100102 Single-Molecule Studies of HIV-1 Protease Catalysis Enabled by Chemical. Introduction Understanding the chemistry of enzyme catalysis has been an important objective of chemical of the chemistry occurring in the enzyme­substrate complex. The physical organic chemistry of enzyme catalysis

  16. CECM Day 2009 IRMACS Expanding HAART to Control the Spread of HIV Among Injection Drug Users

    E-Print Network [OSTI]

    CECM Day 2009 ­ IRMACS Expanding HAART to Control the Spread of HIV Among Injection Drug Users showed, using a risk behaviour-driven, individual-based (cellular automaton) model of injection drug is likely to be unrealistic for many drug treatment programs, where support is provided that may reduce risk

  17. The higher barrier of darunavir and tipranavir resistance for HIV-1 protease

    SciTech Connect (OSTI)

    Wang, Yong; Liu, Zhigang; Brunzelle, Joseph S.; Kovari, Iulia A.; Dewdney, Tamaria G.; Reiter, Samuel J.; Kovari, Ladislau C. (WSU-MED); (NWU)

    2011-11-17T23:59:59.000Z

    Darunavir and tipranavir are two inhibitors that are active against multi-drug resistant (MDR) HIV-1 protease variants. In this study, the invitro inhibitory efficacy was tested against a MDR HIV-1 protease variant, MDR 769 82T, containing the drug resistance mutations of 46L/54V/82T/84V/90M. Crystallographic and enzymatic studies were performed to examine the mechanism of resistance and the relative maintenance of potency. The key findings are as follows: (i) The MDR protease exhibits decreased susceptibility to all nine HIV-1 protease inhibitors approved by the US Food and Drug Administration (FDA), among which darunavir and tipranavir are the most potent; (ii) the threonine 82 mutation on the protease greatly enhances drug resistance by altering the hydrophobicity of the binding pocket; (iii) darunavir or tipranavir binding facilitates closure of the wide-open flaps of the MDR protease; and (iv) the remaining potency of tipranavir may be preserved by stabilizing the flaps in the inhibitor-protease complex while darunavir maintains its potency by preserving protein main chain hydrogen bonds with the flexible P2 group. These results could provide new insights into drug design strategies to overcome multi-drug resistance of HIV-1 protease variants.

  18. INCORPORATION OF VARIABILITY INTO THE MODELING OF VIRAL DELAYS IN HIV INFECTION DYNAMICS

    E-Print Network [OSTI]

    . Banks and D. M. Bortz 1 Center for Research in Scientific Computation Box 8205, North Carolina State for the slow, progressive, and fatal Acquired Immune Deficiency Syndrome (AIDS). According to a Joint United]. HIV­related illness and death is and will continue to be an important clinical and public health issue

  19. INCORPORATION OF VARIABILITY INTO THE MODELING OF VIRAL DELAYS IN HIV INFECTION DYNAMICS

    E-Print Network [OSTI]

    . Banks and D. M. Bortz1 Center for Research in Scientific Computation Box 8205, North Carolina State for the slow, progressive, and fatal Acquired Immune Deficiency Syndrome (AIDS). According to a Joint United]. HIV-related illness and death is and will continue to be an important clinical and public health issue

  20. Irenaeus, a renewal of the early Church

    E-Print Network [OSTI]

    Bond, Patricia Garner

    1983-01-01T23:59:59.000Z

    IRENAEUS: A RENEWAL OF THE EARLY CHURCH A Thesis by PATRICIA GARNER BOND Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF ARTS December 1983 Major Subject...: History IRENAEUS: A RENEWAL OF THE EARLY CHURCH A Thesis by PATRICIA GARNER BOND Approved as to style and content by: ) 4 r Zol tan J. Kopzpolnyik (Cha i dsfan) f +PC'cp C' , - -~c4J Brison D. Gooch (Member) / Georg F. Bass (Me ber) Hen y...

  1. A correlation between light profile and [Mg/Fe] abundance ratio in early-type galaxies

    E-Print Network [OSTI]

    Alexandre Vazdekis; Ignacio Trujillo; Yoshihiko Yamada

    2003-11-27T23:59:59.000Z

    We explore possible correlations between light profile shapes, as parameterized by the Sersic index or the concentration index C_re(1/3), and relevant stellar population parameters in early-type galaxies. Mean luminosity weighted ages, metallicities and abundance ratios were obtained from spectra of very high signal-to-noise and stellar population models that synthesize galaxy spectra at the resolution given by their velocity dispersions, in combination with an age indicator that is virtually free of the effects of metallicity. We do not find any significant correlation between the Sersic index (or C_re(1/3)) and mean age or metallicity, but a strong positive correlation of the shape parameters with [Mg/Fe] abundance ratio. This dependence is as strong as the [Mg/Fe] vs. velocity dispersion and C_re(1/3) vs. velocity dispersion relations. We speculate that early-type galaxies settle up their structure on time-scales in agreement with those imposed by their [Mg/Fe] ratios. This suggest that the global structure of larger galaxies, with larger [Mg/Fe] ratios and shorter time-scales, was already at place at high z, without experiencing a significant time evolution.

  2. Cizelj & Riesch-Oppermann: Modelling the Early Development of... page 1 of 19 MODELING THE EARLY DEVELOPMENT OF

    E-Print Network [OSTI]

    Cizelj, Leon

    . Rather severe stress corrosion cracking has been the major cause of early retirement of PWR steamCizelj & Riesch-Oppermann: Modelling the Early Development of... page 1 of 19 MODELING THE EARLY to be still somewhat in the future. Especially the early phase of the development of cracks, also called

  3. Journal of Climate EARLY ONLINE RELEASE

    E-Print Network [OSTI]

    Hu, Yongyun

    investigate the climate dynamic feedbacks during a transition from the present climate7 to the extremely coldJournal of Climate EARLY ONLINE RELEASE This is a preliminary PDF of the author-produced manuscript. Hu, 2011: The initiation of modern "soft Snowball" and "hard Snowball" climates in CCSM3. Part II

  4. Heart Disease and Early Heart Attack Care

    E-Print Network [OSTI]

    Ohta, Shigemi

    Heart Disease and Early Heart Attack Care Pamela Kostic, RN, CCCC, Chest Pain Coordinator, Stony Risk Factors · EHAC & Prevention #12;Heart disease includes a number of problems affecting the heart and the blood vessels in the heart. #12;Types of heart disease include: · Coronary artery disease (CAD) · Angina

  5. Early diagenetic transformations of peat Original research

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Early diagenetic transformations of peat Original research Organic matter sources and decay;KEY WORDS: bioindicators - carbohydrates - labile organic matter - peat botanical composition to the fate of organic matter (OM) in the underlying peat. Our aims were to determine how moisture conditions

  6. Medieval and Early Modern Events in Durham

    E-Print Network [OSTI]

    Wirosoetisno, Djoko

    's Library (1669) on the UNESCO World Heritage site of Palace Green following a major restoration project exhibition of the Lindisfarne Gospels, and celebrate the rich resources of the city's historic libraries ­ Cosin's Library, the Cathedral Library, and the Library of Ushaw College. · Early Modern Catholicism

  7. Preserving the Colors of Early Cinema

    E-Print Network [OSTI]

    Zanibbi, Richard

    Preserving the Colors of Early Cinema through the Davide Turconi Film Frame Collection Joshua of Chicago 4pm Wed, Sept. 27 Auditorium of the Center for Imaging Science While most surviving silent films as well as Kinetoscope films were colored. Color has thus existed in the cinema since its inception, yet

  8. Misalignment between cold gas and stellar components in early-type galaxies

    E-Print Network [OSTI]

    Wong, O Ivy; Józsa, G I G; Urry, C M; Lintott, C J; Simmons, B D; Kaviraj, S; Masters, K L

    2015-01-01T23:59:59.000Z

    Recent work suggests blue ellipticals form in mergers and migrate quickly from the blue cloud of star-forming galaxies to the red sequence of passively evolving galaxies, perhaps as a result of black hole feedback. Such rapid reddening of stellar populations implies that large gas reservoirs in the pre-merger star-forming pair must be depleted on short time scales. Here we present pilot observations of atomic hydrogen gas in four blue early-type galaxies that reveal increasing spatial offsets between the gas reservoirs and the stellar components of the galaxies, with advancing post-starburst age. Emission line spectra show associated nuclear activity in two of the merged galaxies, and in one case radio lobes aligned with the displaced gas reservoir. These early results suggest that a kinetic process (possibly feedback from black hole activity) is driving the quick truncation of star formation in these systems, rather than a simple exhaustion of gas supply.

  9. June 18, 2012 Symposium on Aging

    E-Print Network [OSTI]

    Church, George M.

    , anemia, muscular dystrophy, and diabetes. The reasons for accelerating research into the molecular diseases of aging such as diabetes, cancer, Alzheimer's and heart disease. Today's attendees come not only

  10. HYGROTHERMAL AGING OF POLYIMIDE MATRIX COMPOSITE LAMINATES

    E-Print Network [OSTI]

    Nairn, John A.

    . The time to initiate water-induced microcracks, tm, (in minutes), was log .t T m = + 3423 1 35 (1) #12-ply laminates and supplied to us by the Boeing Company. For hygrothermal aging experiments, a series

  11. Aging of polymeric composites : a literature review

    E-Print Network [OSTI]

    Treviño-Garrido, Margie N

    2013-01-01T23:59:59.000Z

    Due to their increased use in today's society, an extensive survey was undertaken in this report to condense what's been, thus far, discovered as to the effects of aging on polymeric composites. Special emphasis was placed ...

  12. original article The American Society of Gene & Cell Therapy The continued spread of HIV underscores the need to

    E-Print Network [OSTI]

    Lieberman, Judy

    original article© The American Society of Gene & Cell Therapy The continued spread of HIV protection in mice from intravaginal (IVAG) challenge a week later with a lethal dose of herpes simplex virus

  13. The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

    E-Print Network [OSTI]

    Sok, Devin

    Broadly neutralizing HIV antibodies (bnAbs) are typically highly somatically mutated, raising doubts as to whether they can be elicited by vaccination. We used 454 sequencing and designed a novel phylogenetic method to ...

  14. Examining Public Health System Responses to the Chronic Diseases of HIV/AIDS and Diabetes: Experiences from Mexico and Brazil

    E-Print Network [OSTI]

    Gidi, Virginia Eve

    2010-01-01T23:59:59.000Z

    A. Cohn, Health reform in Brazil: lessons to consider. Am JPetersen, M.L. , et al. , Brazil, in The HIV Pandemic: localof the AIDS epidemic in Brazil: principal epidemiological

  15. Case management to improve adherence for HIV-infected patients receiving antiretroviral therapy in Ethiopia: A micro-costing study

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    Factsheet. 2005. 4. PEPFAR Country Profiles: Ethiopia. [www.pepfar.gov/countries/ ethiopia/index.htm]. 5. ZwillichHospital. 2007, I-TECH Ethiopia. 14. Monthly HIV Care and

  16. Two-step build-up of a thermoreversible polymer network: From early local to late collective dynamics

    E-Print Network [OSTI]

    H. Souguir; O. Ronsin; C. Caroli; T. Baumberger

    2015-03-05T23:59:59.000Z

    We probe the mechanisms at work in the build-up of thermoreversible gel networks, with the help of hybrid gelatin gels containing a controlled density of irreversible, covalent crosslinks (CL), which we quench below the physical gelation temperature. The detailed analysis of the dependence on covalent crosslink density of both the shear modulus and optical activity evolutions with time after quench enables us to identify two stages of the physical gelation process, separated by a temperature dependent crossover modulus: (i) an early nucleation regime during which rearrangements of the triple-helix CL play a negligible role, (ii) a late, logarithmic aging one, which is preserved, though slowed down, in the presence of irreversible CL. We show that aging is fully controlled by rearrangements and discuss the implication of our results in terms of the switch from an early, local dynamics to a late, cooperative long-range one.

  17. Applications of a single-molecule detection in early disease diagnosis and enzymatic reaction study

    SciTech Connect (OSTI)

    Li, Jiangwei

    2008-10-15T23:59:59.000Z

    Various single-molecule techniques were utilized for ultra-sensitive early diagnosis of viral DNA and antigen and basic mechanism study of enzymatic reactions. DNA of human papilloma virus (HPV) served as the screening target in a flow system. Alexa Fluor 532 (AF532) labeled single-stranded DNA probes were hybridized to the target HPV-16 DNA in solution. The individual hybridized molecules were imaged with an intensified charge-coupled device (ICCD) in two ways. In the single-color mode, target molecules were detected via fluorescence from hybridized probes only. This system could detect HPV-16 DNA in the presence of human genomic DNA down to 0.7 copy/cell and had a linear dynamic range of over 6 orders of magnitude. In the dual-color mode, fluorescence resonance energy transfer (FRET) was employed to achieve zero false-positive count. We also showed that DNA extracts from Pap test specimens did not interfere with the system. A surface-based method was used to improve the throughput of the flow system. HPV-16 DNA was hybridized to probes on a glass surface and detected with a total internal reflection fluorescence (TIRF) microscope. In the single-probe mode, the whole genome and target DNA were fluorescently labeled before hybridization, and the detection limit is similar to the flow system. In the dual-probe mode, a second probe was introduced. The linear dynamic range covers 1.44-7000 copies/cell, which is typical of early infection to near-cancer stages. The dual-probe method was tested with a crudely prepared sample. Even with reduced hybridization efficiency caused by the interference of cellular materials, we were still able to differentiate infected cells from healthy cells. Detection and quantification of viral antigen with a novel single-molecule immunosorbent assay (SMISA) was achieved. Antigen from human immunodeficiency virus type 1(HIV-1) was chosen to be the target in this study. The target was sandwiched between a monoclonal capture antibody and a polyclonal detector antibody. The capture antibody was covalently immobilized on modified glass slides. The detector antibody was conjugated with AF532 labeled secondary antibody prior to being used as probe for the antigen. Imaging was performed with a TIRF system. This technique is demonstrated for detecting HIV-1 p24 antigen down to 0.1 pg/mL with a dynamic range of over 4 orders of magnitude. A Langmuir isotherm fit the molecule count dependence on the target concentration. The results also showed that neither sensitivity nor dynamic range was affected by the biological matrix. SMISA is therefore a promising approach for the early diagnosis of virus-induced diseases. Single-molecule enzymatic kinetics and enantioselectivity were monitored in real time by using TIRF microscopy. AF532 labeled poly-L-lysine (PLL) or poly-D-lysine (PDL) was covalently immobilized on a dithiobis (succinimidyl undecanoate) self-assembled monolayer (DSU SAM). Chain shortening due to enzymatic hydrolysis resulted in the reduction of the individual fluorescence intensities. A broad distribution was obtained when 100 single-molecule half-lives were analyzed. However, the detailed hydrolysis process involved also a long-lived component and an induction period that varied significantly among molecules. Charge and steric heterogeneity at the surface are responsible for these features.

  18. Age determination of 15 old to intermediate-age small Magellanic cloud star clusters

    SciTech Connect (OSTI)

    Parisi, M. C.; Clariá, J. J.; Piatti, A. E. [Observatorio Astronómico, Universidad Nacional de Córdoba, Laprida 854, Córdoba, CP 5000 (Argentina); Geisler, D.; Leiton, R. [Departamento de Astronomía, Universidad de Concepción, Casilla 160-C, Concepción (Chile); Carraro, G. [European Southern Observatory, Casilla 19001, Santiago de Chile (Chile); Costa, E. [Universidad de Chile, Casilla 36-D, Santiago de Chile (Chile); Grocholski, A. J. [Department of Physics and Astronomy, Louisiana State University, 202 Nicholson Hall, Tower Drive, Baton Rouge, LA 70803-4001 (United States); Sarajedini, A., E-mail: celeste@oac.uncor.edu, E-mail: claria@oac.uncor.edu, E-mail: andres@oac.uncor.edu, E-mail: dgeisler@astro-udec.cl, E-mail: roger.leiton@astro-udec.cl, E-mail: gcarraro@eso.org, E-mail: costa@das.uchile.cl, E-mail: grocholski@phys.lsu.edu, E-mail: ata@astro.ufl.edu [Department of Astronomy, University of Florida, P.O. Box 112055, Gainesville, FL 32611 (United States)

    2014-04-01T23:59:59.000Z

    We present color-magnitude diagrams in the V and I bands for 15 star clusters in the Small Magellanic Cloud (SMC) based on data taken with the Very Large Telescope (VLT, Chile). We selected these clusters from our previous work, wherein we derived cluster radial velocities and metallicities from calcium II infrared triplet (CaT) spectra also taken with the VLT. We discovered that the ages of six of our clusters have been appreciably underestimated by previous studies, which used comparatively small telescopes, graphically illustrating the need for large apertures to obtain reliable ages of old and intermediate-age SMC star clusters. In particular, three of these clusters, L4, L6, and L110, turn out to be among the oldest SMC clusters known, with ages of 7.9 ± 1.1, 8.7 ± 1.2, and 7.6 ± 1.0 Gyr, respectively, helping to fill a possible 'SMC cluster age gap'. Using the current ages and metallicities from Parisi et al., we analyze the age distribution, age gradient, and age-metallicity relation (AMR) of a sample of SMC clusters measured homogeneously. There is a suggestion of bimodality in the age distribution but it does not show a constant slope for the first 4 Gyr, and we find no evidence for an age gradient. Due to the improved ages of our cluster sample, we find that our AMR is now better represented in the intermediate/old period than we had derived in Parisi et al., where we simply took ages available in the literature. Additionally, clusters younger than ?4 Gyr now show better agreement with the bursting model of Pagel and Tautvaišien?, but we confirm that this model is not a good representation of the AMR during the intermediate/old period. A more complicated model is needed to explain the SMC chemical evolution in that period.

  19. Maturation of the viral core enhances the fusion of HIV-1 particles with primary human T cells and monocyte-derived macrophages

    SciTech Connect (OSTI)

    Jiang Jiyang [Department of Microbiology and Immunology, Vanderbilt University School of Medicine, A-5301 Medical Center North, Nashville, TN 37232-2363 (United States); Aiken, Christopher [Department of Microbiology and Immunology, Vanderbilt University School of Medicine, A-5301 Medical Center North, Nashville, TN 37232-2363 (United States)]. E-mail: chris.aiken@vanderbilt.edu

    2006-03-15T23:59:59.000Z

    HIV-1 infection requires fusion of viral and cellular membranes in a reaction catalyzed by the viral envelope proteins gp120 and gp41. We recently reported that efficient HIV-1 particle fusion with target cells is linked to maturation of the viral core by an activity of the gp41 cytoplasmic domain. Here, we show that maturation enhances the fusion of a variety of recombinant viruses bearing primary and laboratory-adapted Env proteins with primary human CD4{sup +} T cells. Overall, HIV-1 fusion was more dependent on maturation for viruses bearing X4-tropic envelope proteins than for R5-tropic viruses. Fusion of HIV-1 with monocyte-derived macrophages was also dependent on particle maturation. We conclude that the ability to couple fusion to particle maturation is a common feature of HIV-1 Env proteins and may play an important role during HIV-1 replication in vivo.

  20. Journal of the Geological Society, London, Vol. 163, 2006, pp. 291301. Printed in Great Britain. Early Silurian maficultramafic and granitic plutonism in contemporaneous flysch,

    E-Print Network [OSTI]

    Andersen, Torgeir Bjørge

    . 291 Early Silurian mafic­ultramafic and granitic plutonism in contemporaneous flysch, Magerøy and regional metamorphism and were intruded by a mafic­ultramafic complex and various granitic plutons. U granite and 437.7 � 1.6 Ma for the Finnvik granite coincide within error with the age of deposition

  1. A review of "Conscience on Stage: The Comedia as Casuistry in Early Modern Spain" by Hillaire Kallendorf

    E-Print Network [OSTI]

    Wright, Elizabeth

    2009-01-01T23:59:59.000Z

    , social and cultural historians? (20). Hilaire Kallendorf. Conscience on Stage: The Comedia as Casuistry in Early Modern Spain. Toronto: University of Toronto Press, 2007. x + 299 pp. $65. Review by elizabeth r. wright, university of georgia. Spain?s... playwrights. Yet a miniscule proportion of plays have attracted careful and sustained scholarly scrutiny or are performed regularly in repertories. This book reports on one scholar?s project to widen the lens through which we view Spain?s ?Golden Age...

  2. Integrase-independent HIV-1 infection is augmented under conditions of DNA damage and produces a viral reservoir

    SciTech Connect (OSTI)

    Ebina, Hirotaka, E-mail: hebina@virus.kyoto-u.ac.jp; Kanemura, Yuka; Suzuki, Yasutsugu; Urata, Kozue; Misawa, Naoko; Koyanagi, Yoshio

    2012-05-25T23:59:59.000Z

    HIV-1 possesses a viral protein, integrase (IN), which is necessary for its efficient integration in target cells. However, it has been reported that an IN-defective HIV strain is still capable of integration. Here, we assessed the ability of wild type (WT) HIV-1 to establish infection in the presence of IN inhibitors. We observed a low, yet clear infection of inhibitor-incubated cells infected with WT HIV which was identical to cells infected with IN-deficient HIV, D64A. Furthermore, the IN-independent integration could be enhanced by the pretreatment of cells with DNA-damaging agents suggesting that integration is mediated by a DNA repair system. Moreover, significantly faster viral replication kinetics with augmented viral DNA integration was observed after infection in irradiated cells treated with IN inhibitor compared to nonirradiated cells. Altogether, our results suggest that HIV DNA has integration potential in the presence of an IN inhibitor and may serve as a virus reservoir.

  3. High rates of adherence and treatment success in a public and public-private HIV clinic in India: potential benefits of standardized national care delivery systems

    E-Print Network [OSTI]

    Shet, Anita; DeCosta, Ayesha; Heylen, Elsa; Shastri, Suresh; Chandy, Sara; Ekstrand, Maria

    2011-01-01T23:59:59.000Z

    and public-private HIV clinic in India: potential benefitsp clinic waiting times werewas done at three types of clinics in South India: public,

  4. A survey of early warning technologies

    SciTech Connect (OSTI)

    Smith, G.D.; Arlowe, H.D.; Williams, J.D.

    1995-07-01T23:59:59.000Z

    This paper presents a survey of technologies useful in providing early warning in physical security systems. Early warning is important in virtually all types of security systems whether they are used for temporary (tactical, portable, or semi-permanent) applications, border warning, fixed-site detection, or standoff surveillance detection. With the exception of the standoff surveillance detection systems, all systems discussed in this paper usually involve a moving target. The fact that a person(s) to be detected in a standoff surveillance scenario is not moving presents challenging problems and requires different applications of technology. The technologies commonly used to detect moving targets and some suggestions for detection of stationary targets are addressed in this paper.

  5. Photochemical Escape of Oxygen from Early Mars

    E-Print Network [OSTI]

    Zhao, Jinjin

    2015-01-01T23:59:59.000Z

    Photochemical escape is an important process for oxygen escape from present Mars. In this work, a 1-D Monte-Carlo Model is developed to calculate escape rates of energetic oxygen atoms produced from O2+ dissociative recombination reactions (DR) under 1, 3, 10, and 20 times present solar XUV fluxes. We found that although the overall DR rates increase with solar XUV flux almost linearly, oxygen escape rate increases from 1 to 10 times present solar XUV conditions but decreases when increasing solar XUV flux further. Analysis shows that atomic species in the upper thermosphere of early Mars increases more rapidly than O2+ when increasing XUV fluxes. While the latter is the source of energetic O atoms, the former increases the collision probability and thus decreases the escape probability of energetic O. Our results suggest that photochemical escape be a less important escape mechanism than previously thought for the loss of water and/or CO2 from early Mars.

  6. Group, field and isolated early-type galaxies II. Global trends from nuclear data

    E-Print Network [OSTI]

    Denicolo, G; Terlevich, E; Forbes, D A; Terlevich, A I; Denicolo, Glenda; Terlevich, Roberto; Terlevich, Elena; Forbes, Duncan A.; Terlevich, Alejandro

    2004-01-01T23:59:59.000Z

    We have derived ages, metallicities and enhanced-element ratios [alpha/Fe] for a sample of 83 early-type galaxies essentially in groups, the field or isolated objects. The stellar population properties derived for each galaxy corresponds to the nuclear r_e/8 aperture extraction. The median age found for Es is 5.8 +- 0.6 Gyr and the average metallicity is +0.37 +- 0.03 dex. For S0s, the median age is 3.0 +- 0.6 Gyr and [Z/H] = 0.53 +- 0.04 dex. We compare the distribution of our galaxies in the Hbeta-[MgFe] diagram with Fornax galaxies. Our elliptical galaxies are 3-4 Gyr younger than Es in the Fornax cluster. We find that the galaxies lie in a plane defined by [Z/H] = 0.99 log sigma_0 - 0.46 log Age - 1.60. More massive (larger sigma_0) and older galaxies present, on average, large [alpha/Fe] values, and therefore, must have undergone shorter star-formation timescales. Comparing group against field/isolated galaxies, it is not clear that environment plays an important role in determining their stellar populat...

  7. Globular Cluster Ages and Stromgren CCD Photometry

    E-Print Network [OSTI]

    Frank Grundahl

    1999-09-23T23:59:59.000Z

    Stromgren uvby CCD photometry can be used in a variety of ways to constrain the absolute and relative ages of globular clusters. The reddening corrected (v-y, c1) diagram offers the means to derive ages that are completely independent of distance. Very precise differential ages for clusters of the same chemical composition may also be determined from such 2-color plots, or from measurements of the magnitude difference, Delta_u, between the subgiant and horizontal branches on the $u-y, u$ plane (where both of these features are flat and well-defined, even for clusters like M13 that have extremely blue HBs on the (B-V, V) diagram). Based on high-quality photometry we find that: (1) M92 is 15 Gyr old, (2) M3 and M13 differ in age by < 1 Gyr, and (3) NGC 288, NGC 362, and NGC 1851 are coeval to within ~1.5 Gyr. These results strongly suggest that age cannot be the only ``second parameter''. Finally, we suggest that the observed variations in c1 among giant branch stars in all the metal-poor clusters that we have studied so far are likely due to star-to-star C and N abundance variations, and potentially indicate that most (if not all) globular clusters have ``primordial'' variations in at least these elements.

  8. Restructuring and aging in a capillary suspension

    E-Print Network [OSTI]

    Erin Koos; Wolfgang Kannowade; Norbert Willenbacher

    2014-10-16T23:59:59.000Z

    The rheological properties of capillary suspensions, suspensions with small amounts of an added immiscible fluid, are dramatically altered with the addition of the secondary fluid. We investigate a capillary suspension to determine how the network ages and restructures at rest and under applied external shear deformation. The present work uses calcium carbonate suspended in silicone oil (11 % solids) with added water as a model system. Aging of capillary suspensions and their response to applied oscillatory shear is distinctly different from particulate gels dominated by the van der Waals forces. The suspensions dominated by the capillary force are very sensitive to oscillatory flow, with the linear viscoelastic regime ending at a deformation of only 0.1 % and demonstrating power-law aging behavior. This aging persists for long times at low deformations or for shorter times with a sudden decrease in the strength at higher deformations. This aging behavior suggests that the network is able to rearrange and even rupture. This same sensitivity is not demonstrated in shear flow where very high shear rates are required to rupture the agglomerates returning the apparent viscosity of capillary suspensions to the same viscosity as for the pure vdW suspension. A transitional region is also present at intermediate water contents wherein the material response depends very strongly on the type, strength, and duration of the external forcing.

  9. Neutrino Oscillations and the Early Universe

    E-Print Network [OSTI]

    D. P. Kirilova

    2003-12-21T23:59:59.000Z

    The observational and theoretical status of neutrino oscillations in connection with solar and atmospheric neutrino anomalies is presented in brief. The effect of neutrino oscillations on the early Universe evolution is discussed in detail. A short review is given of the standard Big Bang Nucleosynthesis and the influence of resonant and nonresonant neutrino oscillations on active neutrinos and on primordial nucleosynthesis of He-4. BBN cosmological constraints on neutrino oscillation parameters are discussed.

  10. Early Events in Ionic Liquid Radiation Chemistry

    SciTech Connect (OSTI)

    Wishart, J.F.; Cook, A.; Rimmer, R.D.; Gohdo, M.

    2010-09-14T23:59:59.000Z

    Ionic liquids are interesting and useful materials whose solvation time scales are up to thousands of times longer than in conventional solvents. The extended lifetimes of pre-solvated electrons and other energetic species in ionic liquids has profound consequences for the radiolytic product distributions and reactivity patterns. We use a newly developed, multiplexed variation of pulse-probe spectroscopy to measure the kinetics of the early dynamical and reactive events in ionic liquids.

  11. Early-age concrete temperature and moisture relative to curing effectiveness and projected effects on selected aspects of slab behavior

    E-Print Network [OSTI]

    Ye, Dan

    2009-05-15T23:59:59.000Z

    . Palazzolo for serving as advisory committee members. vi TABLE OF CONTENTS Page ABSTRACT .....................................................................................................................iii DEDICATION... ..................................................................................................................iv ACKNOWLEDGMENTS.................................................................................................. v TABLE OF CONTENTS..................................................................................................vi LIST...

  12. Does the early frog catch the worm? Disentangling potential drivers of a parasite age-intensity relationship in tadpoles

    E-Print Network [OSTI]

    Raffel, TR; Lloyd-Smith, JO; Sessions, SK; Hudson, PJ; Rohr, JR

    2011-01-01T23:59:59.000Z

    to urbanization and agrochemicals, echinosto- mes might playTR, Hunter J et al (2008b) Agrochemicals increase trematode

  13. in Yellowstone during the early 1900s, had severely "dam-aged" the park's northern winter range, including decidu-

    E-Print Network [OSTI]

    formulated using the lo- gistic-growth equation (Cole 1974), but more recently, agency biologists have also slated to die from other causes, primarily starvation, and hence predation would not lower ungulate

  14. Secondary state formation during the early iron age on the island of Sri Lanka : the evolution of a periphery

    E-Print Network [OSTI]

    Karunaratne, Priyantha Padmalal

    2010-01-01T23:59:59.000Z

    for concentration on the mineral extraction by the initialresources or raw mineral extraction. Nevertheless, cattlethat control of mineral resource extraction and trade played

  15. Feeding the periphery : modeling early Bronze Age economies and the cultural landscape of the Faynan District, Southern Jordan

    E-Print Network [OSTI]

    Muniz, Adolfo A.

    2007-01-01T23:59:59.000Z

    and desertification in Wadi Faynan. Levant 32, 32:27-52.and Land Use in the Wadi Faynan, Southern Jordan: The Thirdand Desertification in the Wadi Faynan: The Fourth (1999)

  16. adult age groups: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    young (aged 18-35) adults and 10 older (aged 60-80) adults were tested. There was a... James, Vairi A. W. 2009-07-03 16 The Influence of Self-Perceptions of Aging on Older Adults'...

  17. Effects of Age on Meiosis in Budding Yeast

    E-Print Network [OSTI]

    Boselli, Monica

    In humans, the frequency with which meiotic chromosome mis-segregation occurs increases with age. Whether age-dependent meiotic defects occur in other organisms is unknown. Here, we examine the effects of replicative aging ...

  18. Phoebe Barnard & Marienne de Villiers Biodiversity early warning systems

    E-Print Network [OSTI]

    de Villiers, Marienne

    edited by Phoebe Barnard & Marienne de Villiers Biodiversity early warning systems South African-0-620-51837-6 Recommended citation: Barnard, P. & de Villiers, M. (eds). 2012. Biodiversity early warning systems: South

  19. SNEWS: The SuperNova Early Warning System

    E-Print Network [OSTI]

    Antonioli, P

    2004-01-01T23:59:59.000Z

    This paper provides a technical description of the SuperNova Early Warning System (SNEWS), an international network of experiments with the goal of providing an early warning of a galactic supernova.

  20. SNEWS: The SuperNova Early Warning System

    E-Print Network [OSTI]

    P. Antonioli

    2004-07-30T23:59:59.000Z

    This paper provides a technical description of the SuperNova Early Warning System (SNEWS), an international network of experiments with the goal of providing an early warning of a galactic supernova.

  1. 15.391 Early Stage Capital, Fall 2003

    E-Print Network [OSTI]

    Loessberg, Shari

    15.391 examines the elements of raising early stage capital, focusing on start-up ventures and the early stages of company development. This course also prepares entrepreneurs to make the best use of outside advisors, and ...

  2. New Report: Early Lessons Learned in Bringing SSL to Market

    Broader source: Energy.gov [DOE]

    The U.S. Department of Energy (DOE) has published a new report that documents early challenges and lessons learned in the development of the SSL market. Entitled Solid-State Lighting: Early Lessons...

  3. Increasing Creel Interview Efficiency Through Early Survey Termination

    E-Print Network [OSTI]

    Increasing Creel Interview Efficiency Through Early Survey Termination HAL R. OSBURN and MIKE G were terminated early when no angler interviews were con ducted by a specified time. Using this method, terminating

  4. Opportunities for the Early Production of Fischer-Tropsch (F...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    for the Early Production of Fischer-Tropsch (F-T) Fuels in the U.S. -- An Overview Opportunities for the Early Production of Fischer-Tropsch (F-T) Fuels in the U.S. -- An Overview...

  5. Deepwater Horizon Oil Spill; Draft Programmatic and Phase III Early

    E-Print Network [OSTI]

    Deepwater Horizon Oil Spill; Draft Programmatic and Phase III Early Restoration Plan of the Deepwater Horizon oil spill. The restoration alternatives are comprised of early restoration project types Addressing Injuries Resulting from the Deepwater Horizon Oil Spill (Framework Agreement). Criteria

  6. age horizontal branch: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Stars as an Age Indicator Astrophysics (arXiv) Summary: Surface temperature distribution of horizontal-branch (HB) stars is very sensitive to age in old stellar systems,...

  7. aging female sencar: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    should increase with age after puberty. To test this, we examined age Pierce, Graham 57 Perception of Conspecific Female Pheromone Stimulates Female Calling in an Arctiid Moth,...

  8. age estimation: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    face Wiskott, Laurenz 7 OPTIMUM ALWCATION FOR ESTIMATING AGE COMPOSITION USING AGE-LENGTH KEY Environmental Sciences and Ecology Websites Summary: OPTIMUM ALWCATION FOR...

  9. Diagnostic and Prognostic Analysis of Battery Performance & Aging...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Prognostic Analysis of Battery Performance & Aging based on Kinetic and Thermodynamic Principles Diagnostic and Prognostic Analysis of Battery Performance & Aging based on...

  10. THYROID HORMONE REVERSES AGING-INDUCED MYOCARDIAL FATTY ACID...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    occurs during aging in humans and mice and may contribute to development of heart failure. Aging also impairs myocardial fatty acid oxidation, causing increased...

  11. aging tumor growth: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1983), provide valuable data on the age 85 AGE AND GROWTH OF SKIPJACK TUNA, KATSUWONUS PELAMIS, AND YELLOWFIN TUNA, THUNNUS ALBACARES, AS INDICATED Environmental Sciences and...

  12. age site south: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Ohio Department of Aging, The Aging Network, The Ohio State University, The United States Department of Agriculture and County Commissioners Cooperating. Engineering Websites...

  13. Aging assessment for active fire protection systems

    SciTech Connect (OSTI)

    Ross, S.B. [Science and Engineering Associates, Inc. (United States); Nowlen, S.P.; Tanaka, T. [Sandia National Labs., Albuquerque, NM (United States)

    1995-06-01T23:59:59.000Z

    This study assessed the impact of aging on the performance and reliability of active fire protection systems including both fixed fire suppression and fixed fire detection systems. The experience base shows that most nuclear power plants have an aggressive maintenance and testing program and are finding degraded fire protection system components before a failure occurs. Also, from the data reviewed it is clear that the risk impact of fire protection system aging is low. However, it is assumed that a more aggressive maintenance and testing program involving preventive diagnostics may reduce the risk impact even further.

  14. Coronal Temperature as an Age Indicator

    E-Print Network [OSTI]

    Hwankyung Sung; M. S. Bessell; Hugues Sana

    2008-03-26T23:59:59.000Z

    The X-ray spectra of late type stars can generally be well fitted by a two temperature component model of the corona. We fnd that the temperature of both components are strong functions of stellar age, although the temperature of the hotter plasma in the corona shows a larger scatter and is probably affected by the activity of stars, such as flares. We confirm the power-law decay of the temperature of the hot plasma, but the temperature of the cool component decays linearly with log (age).

  15. Aging assessment of reactor instrumentation and protection system components. Aging-related operating experiences

    SciTech Connect (OSTI)

    Gehl, A.C.; Hagen, E.W. [Oak Ridge National Lab., TN (United States)

    1992-07-01T23:59:59.000Z

    A study of the aging-related operating experiences throughout a five-year period (1984--1988) of six generic instrumentation modules (indicators, sensors, controllers, transmitters, annunciators, and recorders) was performed as a part of the Nuclear Plant Aging Research Program. The effects of aging from operational and environmental stressors were characterized from results depicted in Licensee Event Reports (LERs). The data are graphically displayed as frequency of events per plant year for operating plant ages from 1 to 28 years to determine aging-related failure trend patterns. Three main conclusions were drawn from this study: (1) Instrumentation and control (I&C) modules make a modest contribution to safety-significant events: 17% of LERs issued during 1984--1988 dealt with malfunctions of the six I&C modules studied, and 28% of the LERs dealing with these I&C module malfunctions were aging related (other studies show a range 25--50%); (2) Of the six modules studied, indicators, sensors, and controllers account for the bulk (83%) of aging-related failures; and (3) Infant mortality appears to be the dominant aging-related failure mode for most I&C module categories (with the exception of annunciators and recorders, which appear to fail randomly).

  16. Effect of non-ageing and ageing ceria nanoparticles suspensions on fresh water micro-algae

    E-Print Network [OSTI]

    Boyer, Edmond

    Effect of non-ageing and ageing ceria nanoparticles suspensions on fresh water micro-algae Manier nanoparticle (nCeO2) suspensions, towards freshwater micro-algae assessing the effect nCeO2 suspensions microscopy (TEM). In addition, the interaction between NPs and algae were investigated using flow

  17. Structural and Functional Studies of the Receptor-binding and Glycosaminogly-canbinding Mechanisms of a Viral Chemokine Analog vMIP-II and Rational Design of Chemokine-based Highly Potent HIV-1 Entry Inhibitors

    E-Print Network [OSTI]

    Zhao, Bo

    2012-07-16T23:59:59.000Z

    ............................................................................................... 82 Table 4.1 Anti-HIV activities of the chimeric inhibitors in R5 cell-cell fusion assay ................................................................................................... 102 Table 4.2 Anti-HIV activities of the chimeric... assay ......... 106 Table 4.6 Anti-HIV activities of the chimeric inhibitors in X4 cell-cell fusion assay ................................................................................................... 106 Table 4.7 Anti-HIV activities of 5P...

  18. Land use planning and early warning systems for limiting drought

    E-Print Network [OSTI]

    Land use planning and early warning systems for limiting drought impacts and promoting recovery J response 3b. Drought early warning systems #12;Land classification based on the land's potential: soils response 3b. Drought early warning systems #12;Grassland Shrubland ­ high wind erosion Knowledge

  19. AN EARLY WARNING SYSTEM FOR AMBIENT ASSISTED LIVING

    E-Print Network [OSTI]

    Karlsson, Brynjar

    AN EARLY WARNING SYSTEM FOR AMBIENT ASSISTED LIVING June 2012 Andrea Monacchi Master of Science in Computer Science #12;#12;AN EARLY WARNING SYSTEM FOR AMBIENT ASSISTED LIVING Andrea Monacchi Master ISSN 1670-8539 #12;#12;An Early Warning System for Ambient Assisted Living by Andrea Monacchi Project

  20. A TEST OF EARTHQUAKE EARLY WARNING SYSTEM USING LOW COST

    E-Print Network [OSTI]

    Wu, Yih-Min

    A TEST OF EARTHQUAKE EARLY WARNING SYSTEM USING LOW COST ACCELEROMETER IN HUALIEN, TAIWAN Y.-M. Wu early warning system was first motivated by the Hualien offshore earthquake (Mw = 7.8) in November 15 Abstract The earthquake early warning (EEW) research group at the National Taiwan University (NTU) and one

  1. Towards Early Warning Systems Challenges, Technologies and Architecture

    E-Print Network [OSTI]

    Meier, Michael

    Towards Early Warning Systems ­ Challenges, Technologies and Architecture Martin Apel1 , Joachim early warning system (EWS) that aims at providing predictions and advice regarding security threats-scale acquisition of pertinent information by an early warning system (EWS) arises the opportunity to draw up

  2. Tsunami early warning using earthquake rupture duration Anthony Lomax1

    E-Print Network [OSTI]

    Rawlinson, Nick

    -Indonesian tsunami early warning system (GITEWS) and the West Coast and Alaska (WCATWC), and Pacific (PTWC) TsunamiTsunami early warning using earthquake rupture duration Anthony Lomax1 and Alberto Michelini2] Effective tsunami early warning for coastlines near a tsunamigenic earthquake requires notification within 5

  3. Early Warning Signals for Critical Transitions: A Generalized Modeling Approach

    E-Print Network [OSTI]

    for early warning signals that integrates multiple sources of information and data about the system throughEarly Warning Signals for Critical Transitions: A Generalized Modeling Approach Steven J. Lade a previously published fisheries model. We regard our method as complementary to existing early warning signals

  4. The Monitoring and Early Detection of Internet Worms

    E-Print Network [OSTI]

    Shenoy, Prashant

    to our society, it is necessary to set up a nation-scale worm-monitoring and early-warning system. (The to give people accurate early warning information and possible reaction time for counteractions1 The Monitoring and Early Detection of Internet Worms Cliff C. Zou, Weibo Gong, Fellow, IEEE, Don

  5. Mortality transition and differential incentives for early retirement

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Mortality transition and differential incentives for early retirement Hippolyte d'Albis Sau for early retirement; years- to-consume effect; lifetime human wealth effect We are grateful to Robert. In this article, we continue this line of inquiry by studying the differential incentives for early retirement

  6. Checkpointed Early Load Retirement Nevin Kirman Meyrem Kirman Mainak Chaudhuri

    E-Print Network [OSTI]

    Sirer, Emin Gun

    Checkpointed Early Load Retirement Nevin Kirman Meyrem Kirman Mainak Chaudhuri£ Jos´e F. Mart propose checkpointed early load retirement, a mechanism that combines register check- pointing and back-value prediction to consumers, and (3) EARly-retiring the long-latency load. This unclogs the ROB, thereby

  7. An HIV Feedback-Resistor: Auto-Regulatory Circuit Deactivator and Noise Buffer

    E-Print Network [OSTI]

    Leor S. Weinberger; Thomas Shenk

    2007-01-09T23:59:59.000Z

    Many viruses have the cunning ability to enter a hibernative or off state, termed latency or lysogeny. When in a latent state, the virus is unable to replicate, and its gene expression program is largely shut down. This facility for lying dormant typically ensures lifelong persistence of the virus in the host; it is also a particularly problematic obstacle in the treatment of HIV. For most viruses, the molecular regulation of entry into latency is not completely understood, but it is believed that viral gene expression must be deactivated in some way. In this study, we introduce a new regulatory motif, the feedback resistor, that enables a genetic circuit to shut off without the need for an active repressor molecule. We first show that many animal viruses might encode feedback resistors in their regulatory circuits. Then, by using a combination of mathematical theory and single-cell real-time imaging experiments, we show that a feedback resistor in the HIV Tat transcriptional circuit likely allows the HIV virus to enter into latency. We postulate that feedback resistors may give increased stability and control in the complex noisy signaling environment of the cell.

  8. Influence of early Miocene tectonism on Miocene deposystems, Tejon area, Kern County, California

    SciTech Connect (OSTI)

    Hirst, B.M.

    1986-04-01T23:59:59.000Z

    The Tejor area, located in the southeastern end of the San Joaquin Valley of California, provides an excellent opportunity to study earliest Miocene tectonics and their subsequent control on Miocene deposystems in the east slope setting. Abundant outcrop and subsurface control, correlative time markers (including volcanic units and micropaleontologic reports), and a relatively mild overprinting by recent structuring facilitated this 3-year study. Late Zemorrian through early Saucesian (22 Ma) volcanic flows and eruptives covered the area while coincident tensional faulting caused the Zemorrian-age Vedder shelf-slope system to collapse. A horst-and-graben basin system resulted, with a narrow serrated shelf along the eastern margin. Onset of Saucesian deposition was dominated by conglomeratic turbidites spilling into silled basin depocenters. The clastic load included typical Sierran-derived material and volcanic detritus from the prior flows. Rugged sea floor relief controlled channel courses and sediment thickness. Turbidite deposition continued through the earliest Mohnian. The early Saucesian sea flow topography exerted progressively less effect on channel courses, while influence from previous channel buildups increased. Clastic sorting improved with time as the shelf matured and the slope gradient decreased, and clean reservoir channel sands were deposited in meanderlike patterns. This sequence of events is critical to working the structural and stratigraphic hydrocarbon potential of the Tejon area. Zemorrian Vedder and Eocene-age production is associated with paleohorst blocks (e.g., Tejon North oil field and Tunis Creek pool of the Tejon Hills oil field).

  9. FORUM REVIEW ARTICLE Alternative Perspectives on Aging

    E-Print Network [OSTI]

    Gems, David

    mechanisms at the heart of the aging process are a long-standing mystery. An influential theory has that limit lifespan (4, 5). We will first briefly outline the crisis in the oxidative damage theory, then de, the nematode Caenorhabditis elegans. The Oxidative Damage Theory in Crisis Many studies that have used C

  10. Characterizing mechanical effects of aging damage

    SciTech Connect (OSTI)

    Sewell, T.D.; Chen, S.P.; Schoonover, J.R.; Trent, B.C.; Howe, P.M.; Hjelm, R.P.; Browning, R.V.

    1998-12-01T23:59:59.000Z

    This is the final report of a two-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The goal was to develop and apply several different experimental and theoretical/computational tools to better understand physical and chemical aging phenomena in plastic-bonded high explosives, and to develop a methodology for predicting the likely effects of aging on the mechanical properties of the composite based on input from these fundamental studies. Initial comparisons were done for spectra of fresh and aged Esane, as well as PBX-9501, and the authors found differences in the carbonyl region of the spectrum, which possibly reflect differences in hydrogen bonding due to aging phenomena. The micromechanical model of composites was extended to study various volume fractions of HMX with binders. The results showed that, as the binder fraction increases, there is a decrease in the maximum stress that can be supported but an increase in the percent strain at final fracture. A more realistic microstructural model was obtained through the use of a phase field model. Using this model, the authors have studied the microstructural evolution as a function of the grain boundary energy vs. misorientation relationship. The initial results indicate that there are some changes in the grain growth rate when the grain-boundary energy dependence on the angle is not constant. They also find that solute tends to segregate at the grain boundary and slows the grain growth kinetics.

  11. Bitcoin and the Age of Bespoke Silicon

    E-Print Network [OSTI]

    Wang, Deli

    Bitcoin and the Age of Bespoke Silicon Michael B. Taylor Associate Professor University of California, San Diego #12;This Talk Introduction An Overview of the Bitcoin Cryptocurrency Bitcoin's Computing Evolution Bespoke Silicon #12;Interesting Facts about Bitcoin The most successful digital

  12. Thermal aging of nitroplasticized Estane 5703

    SciTech Connect (OSTI)

    Orler, E. B. (E. Bruce); Wrobleski, Debra A.; Cooke, D. W. (D. Wayne); Bennett, B. L. (Bryan L.); Smith, M. E. (Mark E.); Jahan, M. S. (M. Shan)

    2002-01-01T23:59:59.000Z

    In support of the Lifetime Prediction modeling effort, we have been investigating the aging processes that could impact the lifetime of PBX 9501. PBX 9501 is composed of 95% HMX and 5% polymeric binder. The polymeric binder is composed of 50% nitroplasticizer (NP) and 50% Estane{reg_sign} 5703 with a small quantity of stabilizer. Estane{reg_sign} 5703 is a segmented poly(ester urethane) with mechanical properties derived from phase separation of hard and soft segments along the polymer backbone. Since the binder has a significant effect on the composite mechanical properties, it is essential to know how the binder changes with time. Typically, polymer lifetime predictions are determined from extrapolation of properties after the material has been exposed to elevated temperatures and/or reactive environments for varying periods of time. For multiphase polymers, this accelerated aging methodology is very difficult to interpret since elevated temperatures alter the physical structure of the polymer, as well as, accelerate the chemical degradation reactions. Accelerated aging studies of nitroplasticized Estane have shown an increase in the molecular weight. The increase in molecular weight is most likely due to polymer chain branching reactions that eventually leads to formation an insoluble cross-linked gel. The decreased chain mobility caused by branching may also affect phase separation, which in turn, may change the mechanical properties. In this paper we report results of thermal aging studies on the properties, morphology and chemistry of nitroplasticized Estane.

  13. Eligibility: Cancer Survivor ages 35-75

    E-Print Network [OSTI]

    Walter, Peter

    Eligibility: · Cancer Survivor ages 35-75 · Patient has completed treatment within last two years for non-metastic solid tumor · Patient's cancer is currently considered stable or in remission · At least. Please contact Missy Buchanan 415-353-7019 for more information. Helen Diller Family Comprehensive Cancer

  14. Aging and Place: Building Health Promotion into

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    Aging and Place: Building Health Promotion into Long-Term Care IHRP Brownbag May 21, 2013 Naoko-being in social contexts. ­ To improve quality of services by building health promotion into long-term care. #12 ­ U.S. 3. Building health promotion into long-term care ­ Why important? ­ Challenges

  15. Utah Commission on Aging June 16, 2009

    E-Print Network [OSTI]

    Tipple, Brett

    is focusing on fall prevention, end of life care, and elder abuse issues, all of which fall under the auspices Cherie Brunker Health Care Shauna O'Neil Area Agencies on Aging Robert Archuleta Ethnic Minorities Helen-Michele Church Department of Human Services Kent Alderman Legal Profession Gary Kelso Long-Term Care Jo

  16. Business Model Change in Early-Stage Entrepreneurial Firms Facing High Uncertainty BUSINESS MODEL CHANGE IN EARLY-STAGE ENTREPRENEURIAL

    E-Print Network [OSTI]

    Mottram, Nigel

    Business Model Change in Early-Stage Entrepreneurial Firms Facing High Uncertainty 1 BUSINESS MODEL Business School, U.K. Changing business models is inevitable for early-stage entrepreneurial firms striving in elements of business models in a set of eight early-stage university spin-offs. Findings suggest

  17. Seeing Sound Waves in the Early Universe

    E-Print Network [OSTI]

    Arthur Kosowsky

    1998-11-10T23:59:59.000Z

    Temperature and polarization power spectra of the cosmic microwave background can provide essentially incontrovertible evidence for coherent acoustic oscillations in the early universe. A simple model calculation demonstrates explicitly how polarization couples to velocities at the surface of last scatter and is nearly independent of gravitational or density perturbations. For coherent acoustic oscillations, peaks in the temperature and polarization power spectra are precisely interleaved. If observed, such a signal would provide strong support for initial density perturbations on scales larger than the horizon, and thus for inflation.

  18. Neutrino oscillations in the early Universe

    E-Print Network [OSTI]

    D. Kirilova; M. Chizhov

    2001-02-09T23:59:59.000Z

    We discuss the oscillations effects on neutrinos in the early Universe and update the cosmological constraints on the oscillation parameters. It is shown that sterile LOW solution to the solar neutrino problem is almost completely excluded from cosmological nucleosynthesis considerations. Two possibilities for the relaxation of this constraint are discussed: high primordial helium-4 yield and a relic lepton asymmetry present at nucleosynthesis epoch. The numerical analysis proved that Y_p=0.25 only relaxes the constraint on LOW solution, while L > 10^{-5} is capable to remove it.

  19. Nucleosynthesis in Early Neutrino Driven Winds

    SciTech Connect (OSTI)

    Hoffman, R; Fisker, J; Pruet, J; Woosley, S; Janka, H; Buras, R

    2008-01-09T23:59:59.000Z

    Two recent issues related to nucleosynthesis in early proton-rich neutrino winds are investigated. In the first part we investigate the effect of nuclear physics uncertainties on the synthesis of {sup 92}Mo and {sup 94}Mo. Based on recent experimental results, we find that the proton rich winds of the model investigated here can not be the only source of the solar abundance of {sup 92}Mo and {sup 94}Mo. In the second part we investigate the nucleosynthesis from neutron rich bubbles and show that they do not contribute to the nucleosynthesis integrated over both neutron and proton-rich bubbles and proton-rich winds.

  20. Names and Titles in Early Tibetan Records

    E-Print Network [OSTI]

    Richardson, Hugh Edward

    1985-01-01T23:59:59.000Z

    and the Myang Btsun Khri Bo, the head of a Myang principality which may have been the heritage of the great minister Myang Mang Po Rje Zhang Snang who was all­ powerful in the early d:1YS of Srong Brtsan Sgam Po and was disgraced an,1 executed in about 636... -father in power, is called Myang Mang Po Rje Zhang Snang. His family may have been awarded the status of rgyal phran for this service. Mang Po Rje is also found as part of the names of persons of special distinction from the Mgar Khu, Dba's and Cog Ro rus...

  1. Names and Titles in Early Tibetan Records

    E-Print Network [OSTI]

    Richardson, Hugh Edward

    1967-02-10T23:59:59.000Z

    of the great minister Myang Mang Po Rje Zhang Snang who was all­ powerful in the early days of Srong Brtsan Sgam Po and was disgraced and executed in about 636,10 Other personages who may have been included among the rgyal phran can be seen in documents... . ~I he third edict mentions a ~fyang rgyal phran; the great minister of Srong Brtsan Sgam Po whose father led the movement which put Srong Brtsan's grand-father in power, is called Myang Mang Po Rje Zhang Snang. His family may have been awarded...

  2. Quantum Statistical Processes in the Early Universe

    E-Print Network [OSTI]

    B. L. Hu

    1993-02-22T23:59:59.000Z

    We show how the concept of quantum open system and the methods in non-equilibrium statistical mechanics can be usefully applied to studies of quantum statistical processes in the early universe. We first sketch how noise, fluctuation, dissipation and decoherence processes arise in a wide range of cosmological problems. We then focus on the origin and nature of noise in quantum fields and spacetime dynamics. We introduce the concept of geometrodynamic noise and suggest a statistical mechanical definition of gravitational entropy. We end with a brief discussion of the theoretical appropriateness to view the physical universe as an open system.

  3. For Early Adopters | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2: FinalOffers3.pdf0-45.pdf Flash2010-45.pdfFlash2011-43andPropertyFor Early Adopters For

  4. Early Station Costs Questionnaire | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny:RevisedAdvisory Board Contributions EMEMEnergyEarly Station Costs Questionnaire

  5. Evaluating and Improving the ElarmS Earthquake Early Warning Algorithm

    E-Print Network [OSTI]

    Brown, Holly Moore

    2012-01-01T23:59:59.000Z

    based earthquake early warning system for California.Introduction Earthquake early warning systems use seismican earthquake early warning system developed in California.

  6. Central stellar populations of early-type galaxies in low-density environments

    E-Print Network [OSTI]

    M. Collobert; M. Sarzi; R. L. Davies; H. Kuntschner; Matthew Colless

    2006-05-24T23:59:59.000Z

    We have investigated the properties of a volume and magnitude limited sample of nearby early type galaxies that were carefully selected from the AAO two degree field galaxy redshift survey. We used images from the DSS to confirm the E/S0 morphologies, and augmented this sample with field galaxies from Colbert et al. 2001. We present spectroscopic observations of 22 galaxies from the combined sample, from which central velocity dispersions and the Lick stellar population indices were measured. After carefully correcting the spectra for nebular emission we derived luminosity-weighted ages, metallicities, and alpha-element abundance ratios. We compare these isolated galaxies with samples of early-type galaxies in the Virgo and Coma clusters, and also with the sample of galaxies in low-density regions of Kuntschner et al. (2002). We find that galaxies in low-density environments are younger and have a greater spread of ages compared to cluster galaxies. They also show a wider range of metallicities at a given velocity dispersion than cluster galaxies, which display only super-solar metallicities. On average cluster, as well as, isolated galaxies show non-solar abundance ratios in alpha-elements, suggesting that, independent of galactic environment, star formation occurred on short time-scales. We reason that early-type galaxies in low-density environments experienced merging-induced star-formation episodes over a longer and more recent period of time compared to a cluster environment, and speculate that a considerable fraction of their stars formed out of low-metallicity halo gaseous material during the slow growth of a stellar disk between merging events.

  7. http://roa.sagepub.com Research on Aging

    E-Print Network [OSTI]

    Scharer, John E.

    of Early Retirement in Married Men and Women Bettina Kubicek1 , Christian Korunka1 , Peter Hoonakker2 , and James M. Raymo2 Abstract This study presents an integrative model of early retirement using data from satisfaction, and health. The authors assume that these three factors constitute predictors of early retirement

  8. Effects of CCR5-32, CCR2-64I, and SDF-1 3 A Alleles on HIV-1 Disease Progression: An International Meta-Analysis of

    E-Print Network [OSTI]

    Effects of CCR5- 32, CCR2-64I, and SDF-1 3 A Alleles on HIV-1 Disease Progression: An International seroconverters and seroprevalent patients. In contrast, SDF-1 3 A homozygotes showed no decreased risk for AIDS of HIV-1 infection, but SDF-1 3 A homozygosity carried no such protection. Ann Intern Med. 2001

  9. Acceptability of formula-feeding to prevent HIV postnatal transmission, Abidjan, Cte d'Ivoire, 01-04: ANRS 1201/1202 Ditrame-Plus Study

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 Acceptability of formula-feeding to prevent HIV postnatal transmission, Abidjan, Côte d: Acceptability of formula feeding in Africa inserm-00177042,version1-13Jun2008 #12;3 Abstract Objective: To describe the maternal acceptability of formula-feeding proposed to reduce postnatal HIV transmission

  10. The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle stabilized by zinc

    E-Print Network [OSTI]

    Tullius, Thomas D.

    The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle to phosphates in the target DNA. Three domains have been identified in HIV integrase: an amino-terminal domain, a central catalytic core and a carboxy- terminal DNA-binding domain. The amino-terminal region is the only

  11. Solid-State Nuclear Magnetic Resonance Evidence for Parallel and Antiparallel Strand Arrangements in the Membrane-Associated HIV-1 Fusion Peptide

    E-Print Network [OSTI]

    Weliky, David

    Solid-State Nuclear Magnetic Resonance Evidence for Parallel and Antiparallel Strand Arrangements in the Membrane-Associated HIV-1 Fusion Peptide Jun Yang and David P. Weliky* Department of Chemistry, Michigan 7, 2003 ABSTRACT: The HIV-1 fusion peptide serves as a useful model system for understanding viral

  12. Structural Analysis and Assembly of the HIV-1 Gp41 Amino-Terminal Fusion Peptide and the Pretransmembrane Amphipathic-At-Interface Sequence

    E-Print Network [OSTI]

    Pompeu Fabra, Universitat

    Structural Analysis and Assembly of the HIV-1 Gp41 Amino-Terminal Fusion PeptideVised Manuscript ReceiVed September 28, 2006 ABSTRACT: The amino-terminal region within the HIV-1 gp41 aromatic and the gp41 amino-terminal fusion peptide (FP). Here, we have analyzed the structure generated

  13. The 2006 Harvard / Paul F. Glenn Symposium on Aging

    E-Print Network [OSTI]

    Church, George M.

    diseases of aging, such as diabetes, cancer, Alzheimer's and heart disease. A recent study1 concluded

  14. Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury

    E-Print Network [OSTI]

    Nguyen, Hal X; Galvan, Manuel D; Anderson, Aileen J

    2008-01-01T23:59:59.000Z

    Characterization of early and terminal complement proteinsassociation of both early and terminal complement proteinscharacterization of early and terminal complement proteins

  15. Group, field and isolated early-type galaxies II. Global trends from nuclear data

    E-Print Network [OSTI]

    Glenda Denicolo; Roberto Terlevich; Elena Terlevich; Duncan A. Forbes; Alejandro Terlevich

    2004-12-16T23:59:59.000Z

    We have derived ages, metallicities and enhanced-element ratios [alpha/Fe] for a sample of 83 early-type galaxies essentially in groups, the field or isolated objects. The stellar population properties derived for each galaxy corresponds to the nuclear r_e/8 aperture extraction. The median age found for Es is 5.8 +- 0.6 Gyr and the average metallicity is +0.37 +- 0.03 dex. For S0s, the median age is 3.0 +- 0.6 Gyr and [Z/H] = 0.53 +- 0.04 dex. We compare the distribution of our galaxies in the Hbeta-[MgFe] diagram with Fornax galaxies. Our elliptical galaxies are 3-4 Gyr younger than Es in the Fornax cluster. We find that the galaxies lie in a plane defined by [Z/H] = 0.99 log sigma_0 - 0.46 log Age - 1.60. More massive (larger sigma_0) and older galaxies present, on average, large [alpha/Fe] values, and therefore, must have undergone shorter star-formation timescales. Comparing group against field/isolated galaxies, it is not clear that environment plays an important role in determining their stellar population history. In particular, our isolated galaxies show ages differing in more than 8 Gyr. Finally we explore our large spectral coverage to derive log(O/H) metallicity from the N2 indicator and compare it with model-dependent [Z/H]. We find that the O/H abundances are similar for all galaxies, and we can interpret it as if most chemical evolution has already finished in them.

  16. Critical Dynamics in the Early Universe

    E-Print Network [OSTI]

    B. L. Hu

    1993-02-22T23:59:59.000Z

    Methods and concepts for the study of phase transitions mediated by a time-dependent order-parameter field in curved spacetimes are discussed. A practical example is the derivation of an effective (quasi-)potential for the description of `slow-roll' inflation in the early universe. We first summarize our early results on viewing the symmetry behavior of constant background fields in curved but static spacetimes as finite size effect, and the use of derivative expansions for constructing effective actions for slowly-varying background fields. We then introduce the notion of dynamical finite size effect to explain how an exponential expansion of the scale factor imparts a finite size to the system and how the symmetry behavior in de Sitter space can be understood qualitatively in this light. We reason why the exponential inflation can be described equivalently by a scale transformation, thus rendering this special class of dynamics as effectively static. Finally we show how, in this view, one can treat the class of `slow-roll' inflation as a dynamic perturbation off the effectively static class of exponential inflation and understand it as a dynamical critical phenomenon in cosmology.

  17. The Sizes of Early-type Galaxies

    E-Print Network [OSTI]

    Joachim Janz; Thorsten Lisker

    2008-11-20T23:59:59.000Z

    In this letter we present a study of the size luminosity relation of 475 early-type galaxies in the Virgo Cluster with Sloan Digital Sky Survey imaging data. The analysis of our homogeneous, model-independent data set reveals that giant and dwarf early-type galaxies do not form one common sequence in this relation. The dwarfs seem to show weak or no dependence on luminosity, and do not fall on the extension of the rather steep relation of the giants. Under the assumption that the light profile shape varies continuously with magnitude, a curved relation of size and magnitude would be expected. While the galaxies do roughly follow this trend overall, we find that the dwarf galaxies are significantly larger and the low-luminosity giants are significantly smaller than what is predicted. We come to the conclusion that in this scaling relation there is not one common sequence from dwarfs to giants, but a dichotomy which can not be resolved by varying profile shapes. The comparison of our data to a semi-analytic model supports the idea of a physical origin of this dichotomy.

  18. AGES: THE AGN AND GALAXY EVOLUTION SURVEY

    SciTech Connect (OSTI)

    Kochanek, C. S. [Department of Astronomy, Ohio State University, 140 West 18th Avenue, Columbus, OH 43210 (United States); Eisenstein, D. J.; Caldwell, N.; Jones, C.; Murray, S. S.; Forman, W. R.; Green, P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Cool, R. J. [Department of Astrophysical Sciences, Princeton University, Peyton Hall, Princeton, NJ 08544 (United States); Assef, R. J.; Eisenhardt, P.; Stern, D. [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Jannuzi, B. T.; Dey, A. [NOAO, 950 North Cherry Avenue, Tucson, AZ 85719 (United States); Brown, M. J. I. [School of Physics, Monash University, Clayton, Victoria 3800 (Australia); Gonzalez, A. H. [Department of Astronomy, Bryant Space Science Center, University of Florida, Gainesville, FL 32611 (United States)

    2012-05-01T23:59:59.000Z

    The AGN and Galaxy Evolution Survey (AGES) is a redshift survey covering, in its standard fields, 7.7 deg{sup 2} of the Booetes field of the NOAO Deep Wide-Field Survey. The final sample consists of 23,745 redshifts. There are well-defined galaxy samples in 10 bands (the B{sub W} , R, I, J, K, IRAC 3.6, 4.5, 5.8, and 8.0 {mu}m, and MIPS 24 {mu}m bands) to a limiting magnitude of I < 20 mag for spectroscopy. For these galaxies, we obtained 18,163 redshifts from a sample of 35,200 galaxies, where random sparse sampling was used to define statistically complete sub-samples in all 10 photometric bands. The median galaxy redshift is 0.31, and 90% of the redshifts are in the range 0.085 < z < 0.66. Active galactic nuclei (AGNs) were selected as radio, X-ray, IRAC mid-IR, and MIPS 24 {mu}m sources to fainter limiting magnitudes (I < 22.5 mag for point sources). Redshifts were obtained for 4764 quasars and galaxies with AGN signatures, with 2926, 1718, 605, 119, and 13 above redshifts of 0.5, 1, 2, 3, and 4, respectively. We detail all the AGES selection procedures and present the complete spectroscopic redshift catalogs and spectral energy distribution decompositions. Photometric redshift estimates are provided for all sources in the AGES samples.

  19. Age-dependent decay in the landscape

    SciTech Connect (OSTI)

    Winitzki, Sergei [Department of Physics, University of Heidelberg (Germany)

    2008-03-15T23:59:59.000Z

    The picture of the 'multiverse' arising in diverse cosmological scenarios involves transitions between metastable vacuum states. It was pointed out by Krauss and Dent that the transition rates decrease at very late times, leading to a dependence of the transition probability between vacua on the age of each vacuum region. I investigate the implications of this non-Markovian, age-dependent decay on the global structure of the spacetime in landscape scenarios. I show that the fractal dimension of the eternally inflating domain is precisely equal to 3, instead of being slightly below 3, which is the case in scenarios with purely Markovian, age-independent decay. I develop a complete description of a non-Markovian landscape in terms of a nonlocal master equation. Using this description I demonstrate by an explicit calculation that, under some technical assumptions about the landscape, the probabilistic predictions of our position in the landscape are essentially unchanged, regardless of the measure used to extract these predictions. I briefly discuss the physical plausibility of realizing non-Markovian vacuum decay in cosmology in view of the possible decoherence of the metastable quantum state.

  20. The star formation history of early-type galaxies as a function of mass and environment

    E-Print Network [OSTI]

    M. S. Clemens; A. Bressan; B. Nikolic; P. Alexander; F. Annibali; R. Rampazzo

    2006-05-17T23:59:59.000Z

    Using the third data release of the Sloan Digital Sky Survey (SDSS) we have rigorously defined a volume limited sample of early-type galaxies in the redshift range z environment for each galaxy using a method which takes account of the redshift bias introduced by survey boundaries if traditional methods are used. At luminosities greater than our absolute r-band magnitude cutoff of -20.45 the mean density of environment shows no trend with redshift. We calculate the Lick indices for the entire sample and correct for aperture effects and velocity dispersion in a model independent way. Although we find no dependence of redshift or luminosity with environment we do find that the mean velocity dispersion, sigma, of early-type galaxies in dense environments tends to be higher than in low density environments. Taking account of this effect we find that several indices show small but very significant trends with environment that are not the result of the correlation between indices and velocity dispersion. The statistical significance of the data is sufficiently high to reveal that models accounting only for alpha-enhancement struggle to produce a consistent picture of age and metallicity of the sample galaxies, whereas a model that also includes carbon enhancement fares much better. We find that early-type galaxies in the field are younger than those in environments typical of clusters but that neither metallicity, alpha-enhancement nor carbon enhancement are influenced by the environment. The youngest early-type galaxies in both field and cluster environments are those with the lowest sigma. However, there is some evidence that the objects with the largest sigma are slightly younger, especially in denser environments.

  1. 2017 Levelized Costs AEO 2012 Early Release

    U.S. Energy Information Administration (EIA) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTownDells, Wisconsin:Deployment ActivitiesAge Refining Air1, 2015Residential Energy

  2. AEO Early Release 2013 - LNG exports

    U.S. Energy Information Administration (EIA) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTownDells, Wisconsin:Deployment ActivitiesAge Refining Air1, 2015Residential

  3. AEO Early Release 2013 - renewable generation

    U.S. Energy Information Administration (EIA) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro IndustriesTownDells, Wisconsin:Deployment ActivitiesAge Refining Air1,

  4. Early Neutrino Data in the NO$\

    SciTech Connect (OSTI)

    Betancourt, M.; /Minnesota U.

    2011-09-01T23:59:59.000Z

    NO{nu}A is a long-baseline neutrino experiment using an off-axis neutrino beam produced by the NuMI neutrino beam at Fermilab. The NO{nu}A experiment will study neutrino {nu}{sub {mu}} {yields} {nu}{sub e} oscillations. A short term goal for the NO{nu}A experiment is to develop a good understanding of the response of the detector. These studies are being carried out with the full Near Detector installed on the surface (NDOS) at Fermilab. This detector is currently running and will acquire neutrino data for a year. Using beam muon neutrino data, quasi-elastic charged-current interactions will be studied. Status of the NDOS running and early data will be shown.

  5. Strategy for early SUSY searches at ATLAS

    E-Print Network [OSTI]

    Shimpei Yamamoto; for the ATLAS collaboration

    2008-01-08T23:59:59.000Z

    The CERN Large Hadron Collider (LHC) is scheduled to commence operation in 2008 and inclusive searches for supersymmetry (SUSY) will be one of our primary tasks in the first days of LHC operation. It is certain that the final state of multijets + missing transverse energy will provide a superior performance in SUSY searches. Strategies to understand the instrumental background and to understand the Standard Model (SM) background are still under development and are urgent issues for the coming data. We describe the strategy for early SUSY searches at the ATLAS experiment using the fist data corresponding to an integrated luminosity up to 1fb^-1, which comprises much progress in the data-driven technique for the SM background estimations.

  6. Early Top Physics at CMS Experiment

    E-Print Network [OSTI]

    Jesus Manuel Vizan

    2008-10-17T23:59:59.000Z

    The top quark was discovered at the Tevatron in 1995. For the last decade the study of its properties has been a major theme in the worldwide experimental high energy physics program. The advent of the LHC opens up a new era in top quark physics; because of the large $t\\bar{t}$ cross-section and the high luminosity, the LHC can be thought of as a top factory. Here we present the prospects and plans for ttbar physics at CMS at an early stage of the experiment, covering from the initial establishment of the top signal, to the first measurements that become possible for an integrated luminosity of 100 $pb^{-1}$, considering a realistic detector performance.

  7. Discovering colorons at the early stage LHC

    SciTech Connect (OSTI)

    Dicus, Duane A. [Center for Particles and Fields and Texas Cosmology Center, University of Texas, Austin, Texas 78712 (United States); Kao, Chung; Sayre, Joshua [Homer L. Dodge Department of Physics and Astronomy and Oklahoma Center for High Energy Physics, University of Oklahoma, Norman, Oklahoma 73019 (United States); Nandi, S. [Department of Physics and Oklahoma Center for High Energy Physics, Oklahoma State University, Stillwater, Oklahoma 74078 (United States)

    2011-05-01T23:59:59.000Z

    Prospects are investigated for the discovery of massive hypergluons using data from the early runs of the Large Hadron Collider. A center of mass energy of 7 TeV and an integrated luminosity of 1 fb{sup -1} or 5 fb{sup -1} are assumed. A phenomenological Lagrangian is adopted to evaluate the cross section of a pair of colored vector bosons (colorons, {rho}-tilde) decaying into four colored scalar resonances (hyperpions, {pi}-tilde), which then decay into eight gluons. The dominant eight-jet background from the production of 8g, 7g1q, 6g2q, and 5g3q is included. We find an abundance of signal events and that realistic cuts reduce the background enough to establish a 5{sigma} signal for the coloron mass of up to 733 GeV with 1 fb{sup -1} or 833 GeV with 5 fb{sup -1}.

  8. Preserving Alaska's early Cold War legacy.

    SciTech Connect (OSTI)

    Hoffecker, J.; Whorton, M.

    1999-03-08T23:59:59.000Z

    The US Air Force owns and operates numerous facilities that were constructed during the Cold War era. The end of the Cold War prompted many changes in the operation of these properties: missions changed, facilities were modified, and entire bases were closed or realigned. The widespread downsizing of the US military stimulated concern over the potential loss of properties that had acquired historical value in the context of the Cold War. In response, the US Department of Defense in 1991 initiated a broad effort to inventory properties of this era. US Air Force installations in Alaska were in the forefront of these evaluations because of the role of the Cold War in the state's development and history and the high interest on the part of the Alaska State Historic Preservation Officer (SHPO) in these properties. The 611th Air Support Group (611 ASG) owns many of Alaska's early Cold War properties, most were associated with strategic air defense. The 611 ASG determined that three systems it operates, which were all part of the integrated defense against Soviet nuclear strategic bomber threat, were eligible for the National Register of Historic Places (NRHP) and would require treatment as historic properties. These systems include the Aircraft Control and Warning (AC&W) System, the Distant Early Warning (DEW) Line, and Forward Operating Bases (FOBs). As part of a massive cleanup operation, Clean Sweep, the 611 ASG plans to demolish many of the properties associated with these systems. To mitigate the effects of demolition, the 611 ASG negotiated agreements on the system level (e.g., the DEW Line) with the Alaska SHPO to document the history and architectural/engineering features associated with these properties. This system approach allowed the US Air Force to mitigate effects on many individual properties in a more cost-effective and efficient manner.

  9. HI in Low-Luminosity Early-Type Galaxies

    E-Print Network [OSTI]

    Tom Oosterloo; Raffaella Morganti; Elaine Sadler

    1998-09-07T23:59:59.000Z

    We discuss the properties of the HI in low-luminosity early-type galaxies. The morphology of the HI is more regular than that of the HI in many more-luminous early-type galaxies. The HI is always distributed in a disk and is more centrally concentrated. The central HI surface densities are higher than in luminous early-type galaxies and are high enough for star formation to occur.

  10. Detection of erythrocytes influenced by aging and type 2 diabetes using atomic force microscope

    SciTech Connect (OSTI)

    Jin, Hua; Xing, Xiaobo [Chemistry Department, Jinan University, Guangzhou 510632 (China)] [Chemistry Department, Jinan University, Guangzhou 510632 (China); Zhao, Hongxia [Chemistry Department, Jinan University, Guangzhou 510632 (China) [Chemistry Department, Jinan University, Guangzhou 510632 (China); Faculty of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510090 (China); Chen, Yong [Institute for Advanced Study, Nanchang University, Nanchang, Jiangxi 330031 (China)] [Institute for Advanced Study, Nanchang University, Nanchang, Jiangxi 330031 (China); Huang, Xun [Chemistry Department, Jinan University, Guangzhou 510632 (China)] [Chemistry Department, Jinan University, Guangzhou 510632 (China); Ma, Shuyuan [Chemistry Department, Jinan University, Guangzhou 510632 (China) [Chemistry Department, Jinan University, Guangzhou 510632 (China); The First Affiliated Hospital, Jinan University, Guangzhou 510632 (China); Ye, Hongyan [Chemistry Department, Jinan University, Guangzhou 510632 (China)] [Chemistry Department, Jinan University, Guangzhou 510632 (China); Cai, Jiye, E-mail: tjycai@jnu.edu.cn [Chemistry Department, Jinan University, Guangzhou 510632 (China)] [Chemistry Department, Jinan University, Guangzhou 510632 (China)

    2010-01-22T23:59:59.000Z

    The pathophysiological changes of erythrocytes are detected at the molecular scale, which is important to reveal the onset of diseases. Type 2 diabetes is an age-related metabolic disorder with high prevalence in elderly (or old) people. Up to now, there are no treatments to cure diabetes. Therefore, early detection and the ability to monitor the progression of type 2 diabetes are very important for developing effective therapies. Type 2 diabetes is associated with high blood glucose in the context of insulin resistance and relative insulin deficiency. These abnormalities may disturb the architecture and functions of erythrocytes at molecular scale. In this study, the aging- and diabetes-induced changes in morphological and biomechanical properties of erythrocytes are clearly characterized at nanometer scale using atomic force microscope (AFM). The structural information and mechanical properties of the cell surface membranes of erythrocytes are very important indicators for determining the healthy, diseased or aging status. So, AFM may potentially be developed into a powerful tool in diagnosing diseases.

  11. Little Ice Age Glaciation in Alaska: A record of recent global climatic change

    SciTech Connect (OSTI)

    Calkin, P.E.; Wiles, G.C.

    1992-03-01T23:59:59.000Z

    General global cooling and temperature fluctuation accompanied by expansion of mountain glaciers characterized the Little Ice Age of about A.D. 1200 through A.D. 1900. The effects of such temperature changes appear first and are strongest at high latitudes. Therefore the Little Ice Age record of glacial fluctuation in Alaska may provide a good proxy for these events and a test for models of future climatic change. Holocene expansions began here as early as 7000 B.P. and locally show a periodicity of 350 years after about 4500 years B.P. The Little Ice Age followed a late Holocene interval of minor ice advance and a subsequent period of ice margin recession lasting one to seven centuries. The timing of expansions since about A.D. 1200 have often varied between glaciers, but these are the most pervasive glacial events of the Holocene in Alaska and frequently represent ice marginal maxima for this interval. At least two major expansions are, apparent in forefields of both land-terminating and fjord-calving glaciers, but the former display the most reliable and detailed climatic record. Major maxima occurred by the 16th century and into the mid-18th century. Culmination of advances occurred throughout Alaska during the 19th century followed within a few decades by general glacial retreat. Concurrently, equilibrium line altitudes have been raised 100-400 m, representing a rise of 2-3 deg C in mean summer temperature.

  12. An efficient algorithm for the earliness-tardiness scheduling problem

    E-Print Network [OSTI]

    Francis Sourd

    2005-09-07T23:59:59.000Z

    Sep 7, 2005 ... An efficient algorithm for the earliness-tardiness scheduling problem. Francis Sourd (Francis.Sourd ***at*** lip6.fr) Safia Kedad-Sidhoum (Safia.

  13. adenovirus early gene: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors CiteSeer Summary: Systemic application of...

  14. adenovirus early antigens: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors CiteSeer Summary: Systemic application of...

  15. Economy and Rhetoric of Exchange in Early Modern Spain

    E-Print Network [OSTI]

    Ruiz, Eduardo German

    2010-01-01T23:59:59.000Z

    Elliott, J. H. Imperial Spain 1469-1716. London: Penguin,2002. ---. Spain and its World 1500-1700. New Haven andin Early Seventeenth- Century Spain. Lewisburg: Bucknell UP,

  16. act early career: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Right: Early Career Funding Opportunities and UNL Resources to Help You Secure Funding University of Nebraska-Lincoln Office of Research and Economic Development...

  17. Early science runs prepare Sequoia for national security missions...

    National Nuclear Security Administration (NNSA)

    Early science runs prepare Sequoia for national security missions | National Nuclear Security Administration Facebook Twitter Youtube Flickr RSS People Mission Managing the...

  18. Fission track evidence for widespread early to Middle miocene...

    Open Energy Info (EERE)

    and Range province Jump to: navigation, search OpenEI Reference LibraryAdd to library Conference Proceedings: Fission track evidence for widespread early to Middle miocene...

  19. Water volume okay; early runoff leads to dry year declaration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Water-volume-okay-early-runoff-leads-to-dry-year-declaration Sign In About | Careers | Contact | Investors | bpa.gov Search News & Us Expand News & Us Projects & Initiatives...

  20. On the seismic age of the Sun

    E-Print Network [OSTI]

    G. Houdek; D. O. Gough

    2007-10-03T23:59:59.000Z

    We use low-degree acoustic modes obtained by the BiSON to estimate the main-sequence age $t_\\odot$ of the Sun. The calibration is accomplished by linearizing the deviations from a standard solar model the seismic frequencies of which are close to those of the Sun. Formally, we obtain the preliminary value $t_\\odot=4.68\\pm0.02 $Gy, coupled with an initial heavy-element abundance $Z=0.0169\\pm0.0005$. The quoted standard errors, which are not independent, are upper bounds implied under the assumption that the standard errors in the observed frequencies are independent.

  1. Asian Age Enterprise Ltd | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof EnergyInnovation in Carbon Capture andsoftwareAsian Age Enterprise Ltd Place:

  2. Age Dating of Mixed SNM--Preliminary Investigations

    SciTech Connect (OSTI)

    Yuan, D., Guss, P. P., Yfantis, E., Klingensmith, A., Emer, D.

    2011-12-01T23:59:59.000Z

    Recently we investigated the nuclear forensics problem of age determination for mixed special nuclear material (SNM). Through limited computational mixing experiments and interactive age analysis, it was observed that age dating results are generally affected by the mixing of samples with different assays or even by small radioactive material contamination. The mixing and contamination can be detected through interactive age analysis, a function provided by the Decay Interaction, Visualization and Analysis (DIVA) software developed by NSTec. It is observed that for mixed SNM with two components, the age estimators typically fall into two distinct clusters on the time axis. This suggests that averaging or other simple statistical methods may not always be suitable for age dating SNM mixtures. Instead, an interactive age analysis would be more suitable for age determination of material components of such SNM mixtures. This work was supported by the National Center for Nuclear Security (NCNS).

  3. Model NOx storage systems: Storage capacity and thermal aging...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Model NOx storage systems: Storage capacity and thermal aging of BaOtheta- Al2O3NiAl(100). Model NOx storage systems: Storage capacity and thermal aging of BaOtheta- Al2O3...

  4. aged primary coolant: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    problem.(1,2 with a variety of functions that often span the different hypotheses of aging.(2) It is unsurprising senescence, is a primary mechanism of organismal aging.(9-13)...

  5. Asphalt Pavement Aging and Temperature Dependent Properties through a Functionally

    E-Print Network [OSTI]

    Paulino, Glaucio H.

    Asphalt Pavement Aging and Temperature Dependent Properties through a Functionally Graded ­ II ­ Asphalt Pavements ­ Effect of Aging ­ Simulations ­ Concluding Remarks #12;3 Objectives Develop) Correspondence Principle based formulation Application: Asphalt concrete pavements (Part II) #12;4 Asphalt

  6. Exercise training modulates apoptotic signaling in the aging rat heart

    E-Print Network [OSTI]

    Kwak, Hyo Bum

    2005-11-01T23:59:59.000Z

    Aging is characterized by a progressive decline in cardiac function. A critical contributor to the age-related impairment in heart function is the loss of cardiac myocytes through ??apoptosis??, or programmed cell death. A dramatic increase...

  7. Microstructural Features in Aged Erbium Tritide Foils

    SciTech Connect (OSTI)

    Gelles, David S.; Brewer, L. N.; Kotula, Paul G.; Cowgill, Donald F.; Busick, C. C.; Snow, C. S.

    2008-01-01T23:59:59.000Z

    Aged erbium tritide foil specimens are found to contain five distinctly different microstructural features. The general structure was of large columnar grains of ErT2. But on a fine scale, precipitates believed to be erbium oxy-tritides and helium bubbles could be identified. The precipitate size was in the range of ~10 nm and the bubbles were of an unusual planar shape on {111} planes with an invariant thickness of ~1 nm and a diameter on the order of 10 nm. Also, an outer layer containing no fine precipitate structure and only a few helium bubbles was present on foils. This layer is best described as a denuded zone which probably grew during aging in air. Finally, large embedded Er2O3 particles were found at low density and non-uniformly distributed, but sometimes extending through the thickness of the foil. A failure mechanism allowing the helium to escape is suggested by observed cracking between bubbles closer to end of life.

  8. Monazite Th-Pb age depth profiling

    SciTech Connect (OSTI)

    Grove, M.; Harrison, T.M. [Univ. of California, Los Angeles, CA (United States)] [Univ. of California, Los Angeles, CA (United States)

    1999-06-01T23:59:59.000Z

    The significant capabilities of the ion microprobe for thermochronometric investigations of geologic materials remain largely unexploited. Whereas {sup 208}Pb/{sup 232}Th spot analysis allows {approximately} 10-mm-scale imaging of Pb loss profiles or overgrowths in sectioned monazite grains, the spatial resolution offered by depth profiling into the surface region of natural crystals is more than two orders of magnitude higher. The authors document here the ability of the high-resolution ion microprobe to detect {sup 208}Pb/{sup 232}Th age differences of < 1 m.y. with better than 0.05 {micro}m depth resolution in the outer micron of Tertiary monazites from the hanging wall of the Himalayan Main Central thrust. Age gradients on this scale are inaccessible to ion microprobe spot analysis or conventional thermal ionization mass spectrometry. Interpretation of the near-surface {sup 208}Pb distributions with available monazite Pb diffusion data illustrates the potential of the approach for recovering continuous, high-temperature thermal history information not previously available.

  9. The 2008 Harvard / Paul F. Glenn Symposium on Aging

    E-Print Network [OSTI]

    Church, George M.

    of aging such as diabetes, cancer, Alzheimer's and heart disease. Thus, a major goal in the coming years

  10. The 2007 Harvard / Paul F. Glenn Symposium on Aging

    E-Print Network [OSTI]

    Church, George M.

    are regulated, leading to novel medicines to forestall and treat diseases of aging such as diabetes, cancer

  11. The 2009 Harvard / Paul F. Glenn Symposium on Aging

    E-Print Network [OSTI]

    Church, George M.

    of aging such as diabetes, cancer, Alzheimer's and heart disease. Thus, a major goal in the coming years

  12. Characterization of thermal aging of duplex stainless steel by SQUID

    SciTech Connect (OSTI)

    Isobe, Y.; Kamimura, A.; Aoki, K.; Nakayasu, F. [Nuclear Fuel Industries, Ltd., Osaka (Japan)

    1995-08-01T23:59:59.000Z

    Thermal aging is a growing concern for long-term-aged duplex stainless steel piping in nuclear power plants. Superconducting QUantum Interference Device (SQUID) was used for the detection of thermal aging of SUS329 rolled duplex stainless steel and SCS16 cast duplex stainless steel. It was found that the SQUID output signal pattern in the presence of AC magnetic field applied to the specimen was sensitive to the changes in electromagnetic properties due to thermal aging.

  13. aged wild-type littermates: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    98504-3144 An age-length key (ALK) is the tra- ditional method for estimating age-stage length samples for relatively costly age determination (age subsamplel. Age...

  14. aged 6-12 diagnosed: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    98504-3144 An age-length key (ALK) is the tra- ditional method for estimating age-stage length samples for relatively costly age determination (age subsamplel. Age...

  15. aging management guideline: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    lack adequate early- and late-seral forest habitat to meet this goal. Sustainable forestry practices can provide earlyseral forest habitat while addressing increasing societal...

  16. An Early Warning System for Asteroid Impact

    E-Print Network [OSTI]

    Tonry, John L

    2010-01-01T23:59:59.000Z

    Earth is bombarded by meteors, occasionally by one large enough to cause a significant explosion and possible loss of life. Although the odds of a deadly asteroid strike in the next century are low, the most likely impact is by a relatively small asteroid, and we suggest that the best mitigation strategy in the near term is simply to move people out of the way. We describe an "early warning" system that could provide a week's notice of most sizable asteroids or comets on track to hit the Earth. This system, dubbed "Asteroid Terrestrial-impact Last Alert System" (ATLAS), comprises two observatories separated by about 100km that simultaneously scan the visible sky twice a night, and can be implemented immediately for relatively low cost. The sensitivity of ATLAS permits detection of 140m asteroids (100 Mton impact energy) three weeks before impact, and 50m asteroids a week before arrival. An ATLAS alarm, augmented by other observations, should result in a determination of impact location and time that is accura...

  17. Water delivery in the Early Solar System

    E-Print Network [OSTI]

    Dvorak, Rudolf; Süli, Áron; Sándor, Zsolt; Galiazzo, Mattia; Pilat-Lohinger, Elke

    2015-01-01T23:59:59.000Z

    As part of the national scientific network 'Pathways to Habitable Worlds' the delivery of water onto terrestrial planets is a key question since water is essential for the development of life as we know it. After summarizing the state of the art we show some first results of the transport of water in the early Solar System for scattered main belt objects. Hereby we investigate the questions whether planetesimals and planetesimal fragments which have gained considerable inclination due to the strong dynamical interactions in the main belt region around 2 AU can be efficient water transporting vessels. The Hungaria asteroid group is the best example that such scenarios are realistic. Assuming that the gas giants and the terrestrial planets are already formed, we monitor the collisions of scattered small bodies containing water (in the order of a few percent) with the terrestrial planets. Thus we are able to give a first estimate concerning the respective contribution of such bodies to the actual water content i...

  18. Quantum origin of the early inflationary Universe

    E-Print Network [OSTI]

    A. O. Barvinsky; A. Yu. Kamenshchik; I. V. Mishakov

    1996-12-02T23:59:59.000Z

    We give a detailed presentation of a recently proposed mechanism of generating the energy scale of inflation by loop effects in quantum cosmology. We discuss the quantum origin of the early inflationary Universe from the no-boundary and tunneling quantum states and present a universal effective action algorithm for the distribution function of chaotic inflationary cosmologies in both of these states. The energy scale of inflation is calculated by finding a sharp probability peak in this distribution function for a tunneling model driven by the inflaton field with large negative constant $\\xi$ of non-minimal interaction. The sub-Planckian parameters of this peak (the mean value of the corresponding Hubble constant $H\\simeq 10^{-5}m_P$, its quantum width $\\Delta H/H\\simeq 10^{-5}$ and the number of inflationary e-foldings $N\\geq 60$) are found to be in good correspondence with the observational status of inflation theory, provided the coupling constants of the theory are constrained by a condition which is likely to be enforced by the (quasi) supersymmetric nature of the sub-Planckian particle physics model.

  19. Black hole formation in the early universe

    E-Print Network [OSTI]

    Latif, M A; Schmidt, W; Niemeyer, J

    2013-01-01T23:59:59.000Z

    Supermassive black holes with up to a $\\rm 10^{9}~M_{\\odot}$ dwell in the centers of present-day galaxies, and their presence has been confirmed at z $\\geq$ 6. Their formation at such early epochs is still an enigma. Different pathways have been suggested to assemble supermassive black holes in the first billion years after the Big Bang. Direct collapse has emerged as a highly plausible scenario to form black holes as it provides seed masses of $\\rm 10^{5}-10^{6}~M_{\\odot}$. Gravitational collapse in atomic cooling haloes with virial temperatures T$_{vir} \\geq 10^{4}$~K may lead to the formation of massive seed black holes in the presence of an intense background UV flux. Turbulence plays a central role in regulating accretion and transporting angular momentum. We present here the highest resolution cosmological large-eddy simulations to date which track the evolution of high-density regions on scales of $0.25$~AU beyond the formation of the first peak, and study the impact of subgrid-scale turbulence. The pe...

  20. EARLY EMISSION FROM TYPE Ia SUPERNOVAE

    SciTech Connect (OSTI)

    Rabinak, Itay; Waxman, Eli [Department of Particle Physics and Astrophysics, Weizmann Institute of Science, Rehovot 76100 (Israel); Livne, Eli, E-mail: itay.rabinak@weizmann.ac.il [Racah Institute of Physics, Hebrew University, Jerusalem (Israel)

    2012-09-20T23:59:59.000Z

    A unique feature of deflagration-to-detonation (DDT) white dwarf explosion models of supernovae of type Ia is the presence of a strong shock wave propagating through the outer envelope. We consider the early emission expected in such models, which is produced by the expanding shock-heated outer part of the ejecta and precedes the emission driven by radioactive decay. We expand on earlier analyses by considering the modification of the pre-detonation density profile by the weak shocks generated during the deflagration phase, the time evolution of the opacity, and the deviation of the post-shock equation of state from that obtained for radiation pressure domination. A simple analytic model is presented and shown to provide an acceptable approximation to the results of one-dimensional numerical DDT simulations. Our analysis predicts a {approx}10{sup 3} s long UV/optical flash with a luminosity of {approx}1 to {approx}3 Multiplication-Sign 10{sup 39} erg s{sup -1}. Lower luminosity corresponds to faster (turbulent) deflagration velocity. The luminosity of the UV flash is predicted to be strongly suppressed at t > t{sub drop} {approx} 1 hr due to the deviation from pure radiation domination.

  1. Metal Enrichment in the Early Galactic Halo

    E-Print Network [OSTI]

    C. Ikuta; N. Arimoto

    1999-06-14T23:59:59.000Z

    An early history of metal enrichment in the Galactic halo is studied. We investigate chemical inhomogeneity by using a stochastic chemical evolution model. The model confronts with metallicity distribution function of long-lived halo stars which is found to be a clue to obtain the best model prescriptions. We find that the star formation in the halo virtually terminated by around 1 Gyr and that the halo has never been chemically homogeneous in its star formation history. This conclusion does not depend whether mass loss from the halo is taken into account or not. Observed ratios of alpha-elements with respect to iron do not show scatters on a [alpha/Fe]-[Fe/H] plane, but this does not imply that interstellar matter in the halo was homogeneous because a chemical evolution path on this diagram is degenerate in the star formation rate. On the other hand, apparent spread of [Sr/Fe] ratio among metal-poor halo stars does not reflect an inhomogeneous metal enrichment, instead it is due to a sharp increase in a production rate of strontium that is probably synthesised in slightly less massive stars than progenitor of iron-producing SNII.

  2. FUNCTIONAL ESTIMATION FOR A MULTICOMPONENT AGE REPLACEMENT MODEL

    E-Print Network [OSTI]

    L'Ecuyer, Pierre

    1 FUNCTIONAL ESTIMATION FOR A MULTICOMPONENT AGE REPLACEMENT MODEL Pierre L'Ecuyer, Benoit Martin, controlled by a replacement rule based on age thresholds. We show how to estimate the expected cost­ generative simulation, maintenance models, age replacement policies. #12; 2 L'ECUYER, MARTIN, AND V ' AZQUEZ

  3. FUNCTIONAL ESTIMATION FOR A MULTICOMPONENT AGE REPLACEMENT MODEL

    E-Print Network [OSTI]

    Vázquez-Abad, Felisa J.

    FUNCTIONAL ESTIMATION FOR A MULTICOMPONENT AGE REPLACEMENT MODEL Pierre L'Ecuyer, Benoit Martin, controlled by a replacement rule based on age thresholds. We show how to estimate the expected cost­ generative simulation, maintenance models, age replacement policies. #12; L'ECUYER, MARTIN, AND V ' AZQUEZ

  4. Early molecular responses of coral larvae to hyperthermal stress

    E-Print Network [OSTI]

    suggests that heat stress might compromise some components of the coral immune defence and therefore might oxidative stress showed little response at the early hours to heat stress, supporting the proposal that upEarly molecular responses of coral larvae to hyperthermal stress MAURICIO RODRIGUEZ-LANETTY,* SAKI

  5. Early Warning System on a National Level Project AMSEL

    E-Print Network [OSTI]

    Flegel, Ulrich

    Early Warning System on a National Level ­ Project AMSEL Martin Apel, Joachim Biskup, Ulrich Flegel.biskup, michael.meier@cs.tu-dortmund.de SAP Research, Vincenz-Prießnitz-Str. 1, 76131 Karlsruhe, Germany ulrich.flegel@sap.com Abstract We present the architecture of an automatic early warning system (EWS) that aims at providing

  6. Ecological Energetics in Early Homo Author(s): Herman Pontzer

    E-Print Network [OSTI]

    Pontzer, Herman

    Ecological Energetics in Early Homo Author(s): Herman Pontzer Reviewed work(s): Source: Current new forms of scholarship. For more information about JSTOR, please contact support.00. DOI: 10.1086/667402 Ecological Energetics in Early Homo by Herman Pontzer CA Online-Only Material

  7. ORIGINAL ARTICLE Early Brain Overgrowth in Autism Associated

    E-Print Network [OSTI]

    Utah, University of

    ORIGINAL ARTICLE Early Brain Overgrowth in Autism Associated With an Increase in Cortical Surface, PhD; Chad Chappell, MA; Rachel Gimpel Smith, BA; Clement Vachet, MS; Joseph Piven, MD Context: Brain. Objective: To investigate early growth trajectories in brain volume and cortical thickness. Design

  8. Early Termination in Sparse Interpolation Erich Kaltofen a

    E-Print Network [OSTI]

    Kaltofen, Erich

    Early Termination in Sparse Interpolation Algorithms Erich Kaltofen a , Wen-shin Lee b a termination, enables different interpolation algo- rithms to adapt to the degree or the number of terms this strategy in sparse interpolation algorithms. Based on early termination, racing algorithms execute

  9. Identification of Early Interstitial Lung Disease in Smokers from the

    E-Print Network [OSTI]

    Identification of Early Interstitial Lung Disease in Smokers from the COPDGene Study George R interstitial lung disease (ILD) on chest computed tomographic (CT) scans. Materials and Methods: The CT scans: Early interstitial lung disease; CT scan; smoker. ªAUR, 2010 I diopathic pulmonary fibrosis (IPF

  10. Application to the Early Entry PhD Option Instructions

    E-Print Network [OSTI]

    Sheridan, Jennifer

    Application to the Early Entry PhD Option Instructions: 1. TYPE required information. (You to the Academic Programs Office: Attention: Carol Aspinwall, Coordinator of PhD Program Academic Student Services that describes your reasons for seeking admission to the Early Entry PhD Option. APPROVAL (For office use only

  11. Breast health problems are rare in both HIV-infected and uninfected women supported to exclusively breastfeed in South Africa

    E-Print Network [OSTI]

    Boyer, Edmond

    to exclusively breastfeed in South Africa RM Bland1,2 , R Becquet1,3,4 , NC Rollins5 , A Coutsoudis5 , HM, Somkhele, South Africa 2 Division of Developmental Medicine, University of Glasgow, UK 3 INSERM, Unité 593Zulu Natal, South Africa 6 Centre for HIV/AIDS Networking, University of KwaZulu Natal, South Africa 7 Centre

  12. QSAR de alguns inibidores peptdicos da enzima HIV-1 protease utilizando "a priori" descritores moleculares e molecular graphics

    E-Print Network [OSTI]

    Ferreira, Márcia M. C.

    moleculares e molecular graphics Rudolf Kiralj (PQ), Márcia Miguel Castro Ferreira (PQ) rudolf-calculator count/calculation using only 1D and 2D chemical formula). A work on COMBINE (COMparative BINding Energy of molecular graphics, are discussed in terms both of the a priori approach and of the HIV-1 protease inhibitor

  13. HIV-1 Tat membrane interactions probed using X-ray and neutron scattering, CD spectroscopy and MD simulations

    E-Print Network [OSTI]

    Nagle, John F.

    HIV-1 Tat membrane interactions probed using X-ray and neutron scattering, CD spectroscopy and MD translocation, were provided by wide-angle X-ray scattering (WAXS) and neutron scattering. CD spectroscopy for Neutron Research, 100 Bureau Drive, Stop 6102, Gaithersburg, MD 20899, United States d CHESS, Cornell

  14. Supplementary data for HIV-1 Tat membrane interaction probed using X-ray and neutron scattering, CD, and MD simulations

    E-Print Network [OSTI]

    Nagle, John F.

    1 Supplementary data for HIV-1 Tat membrane interaction probed using X-ray and neutron scattering- spacing are linearly related. Figure S3. Neutron scattering from stacks of DOPC:DOPE (3:1)/Tat, x=0 of Physics, Rensselaer Polytechnic Institute, 110 Eighth Street, Troy, NY 12180, 3 NIST Center for Neutron

  15. Free Energy Component Analysis for Drug Design: A Case Study of HIV-1 Protease-Inhibitor Binding

    E-Print Network [OSTI]

    Jayaram, Bhyravabotla

    Free Energy Component Analysis for Drug Design: A Case Study of HIV-1 Protease-Inhibitor Binding energy component analysis that conveys information on the physicochemical forces driving the protein for a specific protein target if not in the general case. It is here that the free energy component analysis

  16. The Early Angular Momentum History of Low Mass Stars: Evidence for a Regulation Mechanism

    E-Print Network [OSTI]

    L. M. Rebull; S. C. Wolff; S. E. Strom; R. B. Makidon

    2002-03-21T23:59:59.000Z

    We examine the early angular momentum history of stars in young clusters via 197 photometric periods in fields flanking the Orion Nebula Cluster (ONC), 81 photometric periods in NGC 2264, and 202 measurements of v sin i in the ONC itself. We show that PMS stars spanning an age range from 0.1 to 3 Myr do not appear to conserve stellar angular momentum as they evolve down their convective tracks, but instead preserve the same range of periods even though they have contracted by about a factor of three. This result seems to require a mechanism that regulates the angular velocities of young stars. We discuss several candidate mechanisms. The most plausible appears to be disk-locking, though most of our stars do not have (I-K) excesses suggestive of disks. However, a decisive test of this hypothesis requires a more sensitive diagnostic than the (I-K) excesses used here.

  17. Ageing of Natural Rubber under Stress

    E-Print Network [OSTI]

    S. M. Clarke; F. Elias; E. M. Terentjev

    2000-05-04T23:59:59.000Z

    We report a dynamical-mechanical study of stress relaxation at small deformation in a natural (polyisoprene) rubber well above its glass transition temperature Tg. We find that an almost complete relaxation of stress takes place over very long periods of time, even though the elastic network integrity is fully retained. The relaxation rate and the long-time equilibrium modulus are sensitive functions of temperature which do not follow time-temperature superposition. Many characteristic features of non-ergodic ageing response are apparent at both short and very long times. We interpret the observed behaviour in terms of the properties of rubber crosslinks, capable of isomerisation under stress, and relate the results to recent models of soft glassy rheology.

  18. Dark Energy in the Dark Ages

    E-Print Network [OSTI]

    Eric V. Linder

    2006-04-11T23:59:59.000Z

    Non-negligible dark energy density at high redshifts would indicate dark energy physics distinct from a cosmological constant or ``reasonable'' canonical scalar fields. Such dark energy can be constrained tightly through investigation of the growth of structure, with limits of \\la2% of total energy density at z\\gg1 for many models. Intermediate dark energy can have effects distinct from its energy density; the dark ages acceleration can be constrained to last less than 5% of a Hubble e-fold time, exacerbating the coincidence problem. Both the total linear growth, or equivalently \\sigma_8, and the shape and evolution of the nonlinear mass power spectrum for zenergy behavior over the entire range z=0-1100.

  19. Emerging nondestructive inspection methods for aging aircraft

    SciTech Connect (OSTI)

    Beattie, A; Dahlke, L; Gieske, J [and others

    1994-01-01T23:59:59.000Z

    This report identifies and describes emerging nondestructive inspection (NDI) methods that can potentially be used to inspect commercial transport and commuter aircraft for structural damage. The nine categories of emerging NDI techniques are: acoustic emission, x-ray computed tomography, backscatter radiation, reverse geometry x-ray, advanced electromagnetics, including magnetooptic imaging and advanced eddy current techniques, coherent optics, advanced ultrasonics, advanced visual, and infrared thermography. The physical principles, generalized performance characteristics, and typical applications associated with each method are described. In addition, aircraft inspection applications are discussed along with the associated technical considerations. Finally, the status of each technique is presented, with a discussion on when it may be available for use in actual aircraft maintenance programs. It should be noted that this is a companion document to DOT/FAA/CT-91/5, Current Nondestructive Inspection Methods for Aging Aircraft.

  20. Aging management guideline for commercial nuclear power plants - heat exchangers

    SciTech Connect (OSTI)

    Booker, S.; Lehnert, D.; Daavettila, N.; Palop, E.

    1994-06-01T23:59:59.000Z

    This Aging Management Guideline (AMG) describes recommended methods for effective detection and mitigation of age-related degradation mechanisms in commercial nuclear power plant heat exchangers important to license renewal. The intent of this AMG is to assist plant maintenance and operations personnel in maximizing the safe, useful life of these components. It also supports the documentation of effective aging management programs required under the License Renewal Rule 10 CFR 54. This AMG is presented in a manner that allows personnel responsible for performance analysis and maintenance to compare their plant-specific aging mechanisms (expected or already experienced) and aging management program activities to the more generic results and recommendations presented herein.

  1. Age discrimination protection is not limited to seniors

    SciTech Connect (OSTI)

    Ossi, G.J. [Vennable, LLP (United States)

    2005-12-15T23:59:59.000Z

    The average age of a coal miner in the USA today is over 50. The Age Discrimination in Employment Act of 1967 (ADEA) protects individuals over 40 years of age from employment discrimination based on age. Under ADEA it is unlawful to discriminate based on an employee's age when hiring, firing, promoting, demoting, laying-off, compensating, assigning or training an employee. The author advocates that, although ADEA can be complicated, the best rule is simply to treat older workers the same as younger workers. Advice is given on considering waivers of ADEA claims.

  2. Early Detection of Steel Rebar Corrosion by Acoustic Emission Monitoring Early Detection of Steel Rebar Corrosion by Acoustic Emission

    E-Print Network [OSTI]

    Early Detection of Steel Rebar Corrosion by Acoustic Emission Monitoring Early Detection of Steel Rebar Corrosion by Acoustic Emission Monitoring Alan D. Zdunek and David Prine BIRL Industrial Research, Evanston, IL 60201 Paper No. 547 presented at CORROSION95, the NACE International Annual Conference

  3. ICES/PICES Early Career Scientists Symposium Marine science with global vision: creating a place for early career

    E-Print Network [OSTI]

    North, Elizabeth W.

    the 2007 Early Career Scientists Conference. ­ ICES Journal of Marine Science, 66: 334­335. Received 30 as the international organizations tasked with fostering marine science and applying it to the wise stewardship of their results to the international com- munity. The Early Career Scientists Conference (ECSC) "New Frontiers

  4. Early hydrodynamic evolution of a stellar collision

    SciTech Connect (OSTI)

    Kushnir, Doron; Katz, Boaz [Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540 (United States)

    2014-04-20T23:59:59.000Z

    The early phase of the hydrodynamic evolution following the collision of two stars is analyzed. Two strong shocks propagate from the contact surface and move toward the center of each star at a velocity that is a small fraction of the velocity of the approaching stars. The shocked region near the contact surface has a planar symmetry and a uniform pressure. The density vanishes at the (Lagrangian) surface of contact, and the speed of sound diverges there. The temperature, however, reaches a finite value, since as the density vanishes, the finite pressure is radiation dominated. For carbon-oxygen white dwarf (CO WD) collisions, this temperature is too low for any appreciable nuclear burning shortly after the collision, which allows for a significant fraction of the mass to be highly compressed to the density required for efficient {sup 56}Ni production in the detonation wave that follows. This property is crucial for the viability of collisions of typical CO WD as progenitors of type Ia supernovae, since otherwise only massive (>0.9 M {sub ?}) CO WDs would have led to such explosions (as required by all other progenitor models). The divergence of the speed of sound limits numerical studies of stellar collisions, as it makes convergence tests exceedingly expensive unless dedicated schemes are used. We provide a new one-dimensional Lagrangian numerical scheme to achieve this. A self-similar planar solution is derived for zero-impact parameter collisions between two identical stars, under some simplifying assumptions (including a power-law density profile), which is the planar version of previous piston problems that were studied in cylindrical and spherical symmetries.

  5. Stabilizing Soybean Production in Northeast Texas with Early Planting of Early-Maturing Soybean Varieties.

    E-Print Network [OSTI]

    Bowers, G.R. Jr; Nelson, L.R.; Finch, G.A. III

    1990-01-01T23:59:59.000Z

    a pro longed hot, dry period in July and August, coinciding with the blooming and seed-filling periods of Maturity Groups (MG) V, VI, and VII soybean varieties planted in Mayor early June, which are harvested in October. This traditional soybean... systems/ North east Texas/ yield. rizes the results [rom a 3-year study comparing the agro nom.ic ~rformance of MG III and IV varieties planted in Apnl WIth MG V, VI, and VII varieties planted in May. Materials and Methods Test plots were located...

  6. Element Abundances through the Cosmic Ages

    E-Print Network [OSTI]

    Max Pettini

    2003-03-12T23:59:59.000Z

    The horizon for studies of element abundances has expanded dramatically in the last ten years. Once the domain of astronomers concerned chiefly with stars and nearby galaxies, this field has now become a key component of observational cosmology, as technological advances have made it possible to measure the abundances of several chemical elements in a variety of environments at redshifts up to z = 4, when the universe was in its infancy. In this series of lectures I summarise current knowledge on the chemical make-up of distant galaxies observed directly in their starlight, and of interstellar and intergalactic gas seen in absorption against the spectra of bright background sources. The picture which is emerging is one where the universe at z = 3 already included many of the constituents of today's galaxies-even at these early times we see evidence for Population I and II stars, while the `smoking gun' for Population III objects may be hidden in the chemical composition of the lowest density regions of the intergalactic medium, yet to be deciphered.

  7. IS ACTIVE REGION CORE VARIABILITY AGE DEPENDENT?

    SciTech Connect (OSTI)

    Ugarte-Urra, Ignacio [College of Science, George Mason University, 4400 University Drive, Fairfax, VA 22030 (United States); Warren, Harry P. [Space Science Division, Naval Research Laboratory, Washington, DC 20375 (United States)

    2012-12-10T23:59:59.000Z

    The presence of both steady and transient loops in active region cores has been reported from soft X-ray and extreme-ultraviolet observations of the solar corona. The relationship between the different loop populations, however, remains an open question. We present an investigation of the short-term variability of loops in the core of two active regions in the context of their long-term evolution. We take advantage of the nearly full Sun observations of STEREO and Solar Dynamics Observatory spacecraft to track these active regions as they rotate around the Sun multiple times. We then diagnose the variability of the active region cores at several instances of their lifetime using EIS/Hinode spectral capabilities. We inspect a broad range of temperatures, including for the first time spatially and temporally resolved images of Ca XIV and Ca XV lines. We find that the active region cores become fainter and steadier with time. The significant emission measure at high temperatures that is not correlated with a comparable increase at low temperatures suggests that high-frequency heating is viable. The presence, however, during the early stages, of an enhanced emission measure in the ''hot'' (3.0-4.5 MK) and ''cool'' (0.6-0.9 MK) components suggests that low-frequency heating also plays a significant role. Our results explain why there have been recent studies supporting both heating scenarios.

  8. What makes some campaigns more effective than others?: An analysis of three mass media PSI HIV/AIDS campaigns in Kenya.

    E-Print Network [OSTI]

    Mabachi, Natabhona Marianne

    2008-12-15T23:59:59.000Z

    This study included interviews with campaign planners at a major social marketing organization in Kenya and an examination of three comprehensive HIV/AIDS health campaigns produced by the planners. Thematic and qualitative content analysis...

  9. An evaluation of novel lipid-enveloped nanoparticles for adjuvant and antigen delivery for an HIV vaccine : stepping from laboratory into potential markets

    E-Print Network [OSTI]

    Khodami, Pantea

    2011-01-01T23:59:59.000Z

    Enormous effort has been devoted to the development of a vaccine against human immunodeficiency virus (HIV). The purpose of this paper is to evaluate the technological and economical aspects of a potential vaccine designed ...

  10. Risky Subjectivity : : The Effects of Cultural Discourses of Addiction on Methamphetamine Using HIV+ Men Who Have Sex with Men in San Diego

    E-Print Network [OSTI]

    Gideonse, Theodore Karwoski

    27, 2013. Burroway, Jim Is MRSA The New Gay Plague? Nothttp://www.boxturtlebulletin.com/is-mrsa-the-new-gay-plague.s HIV- based motives, the MRSA outbreaks in the mid 2000s (

  11. Incidence and risk factors for lung cancer among women in the women’s interagency HIV study (WIHS) and men in the multicenter AIDS cohort study (MACS)

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    Incidence and risk factors for lung cancer among women inan increased incidence of lung can- cer among people withis due to HIV or to other lung cancer risk factors such as

  12. Sociodemographic and drug use characteristics, sex behaviors, and motivations for drug use among HIV- seronegative, heterosexual, methamphetamine users in San Diego, CA

    E-Print Network [OSTI]

    Cheng, Wei-Woon Susan

    2009-01-01T23:59:59.000Z

    TL A Comparison of Injection Drug Users (IDU) vs. Non-IDU inDISSERTATIO Sociodemographic and Drug Use Characteristics,and Motivations for Drug Use among HIV-Seronegative,

  13. POLICY ON HIV DISEASE AND AIDS It is the intent of this policy to ensure that those individuals living with the Human Immunodeficiency

    E-Print Network [OSTI]

    Bolding, M. Chad

    POLICY ON HIV DISEASE AND AIDS It is the intent of this policy to ensure that those individuals who feels discriminated against or who has a policy related question should contact the Office

  14. Early Market TRL/MRL Analysis

    SciTech Connect (OSTI)

    Ronnebro, Ewa; Stetson, Ned

    2013-12-01T23:59:59.000Z

    he focus of this report is TRL/MRL analysis of hydrogen storage; it documents the methodology and results of an effort to identify hydrogen storage technologies’ technical and manufacturing readiness for early market motive and non-motive applications and to provide a path forward toward commercialization. Motive applications include materials handling equipment (MHE) and ground support equipment (GSE), such as forklifts, tow tractors, and specialty vehicles such as golf carts, lawn mowers and wheel chairs. Non-motive applications are portable, stationary or auxiliary power units (APUs) and include portable laptops, backup power, remote sensor power, and auxiliary power for recreational vehicles, hotels, hospitals, etc. Hydrogen storage technologies assessed include metal hydrides, chemical hydrides, sorbents, gaseous storage, and liquid storage. The assessments are based on a combination of Technology Readiness Level (TRL) and Manufacturing Readiness Level (MRL) designations that enable evaluation of hydrogen storage technologies at varying levels of development. The manufacturing status could be established from eight risk elements: Technical Maturity, Design, Materials, Cost & Funding, Process Capability, Personnel, Facilities and Manufacturing Planning. This approach provides a logical methodology and roadmap to enable the identification of hydrogen storage technologies, their advantages/disadvantages, gaps and R&D needs on an unbiased and transparent scale that is easily communicated to interagency partners. This technology readiness assessment (TRA) report documents the process used to conduct the TRA/MRA (technology and manufacturing readiness assessment), reports the TRL and MRL for each assessed technology and provides recommendations based on the findings. To investigate the state of the art and needs to mature the technologies, PNNL prepared a questionnaire to assign TRL and MRL for each hydrogen storage technology. The questionnaire was sent to identified hydrogen storage technology developers and manufacturers who were asked to perform a self-assessment. We included both domestic and international organizations including U.S. national laboratories, U.S. companies, European companies and Japanese companies. PNNL collected the data and performed an analysis to deduce the level of maturity and to provide program recommendations.

  15. Aging and weathering of cool roofing membranes

    SciTech Connect (OSTI)

    Akbari, Hashem; Berhe, Asmeret A.; Levinson, Ronnen; Graveline,Stanley; Foley, Kevin; Delgado, Ana H.; Paroli, Ralph M.

    2005-08-23T23:59:59.000Z

    Aging and weathering can reduce the solar reflectance of cool roofing materials. This paper summarizes laboratory measurements of the solar spectral reflectance of unweathered, weathered, and cleaned samples collected from single-ply roofing membranes at various sites across the United States. Fifteen samples were examined in each of the following six conditions: unweathered; weathered; weathered and brushed; weathered, brushed and then rinsed with water; weathered, brushed, rinsed with water, and then washed with soap and water; and weathered, brushed, rinsed with water, washed with soap and water, and then washed with an algaecide. Another 25 samples from 25 roofs across the United States and Canada were measured in their unweathered state, weathered, and weathered and wiped. We document reduction in reflectivity resulted from various soiling mechanisms and provide data on the effectiveness of various cleaning approaches. Results indicate that although the majority of samples after being washed with detergent could be brought to within 90% of their unweathered reflectivity, in some instances an algaecide was required to restore this level of reflectivity.

  16. LIGA microsystems aging : evaluation and mitigation.

    SciTech Connect (OSTI)

    Cadden, Charles H.; Yang, Nancy Y. C.; San Marchi, Christopher W.

    2003-12-01T23:59:59.000Z

    The deployment of LIGA structures in DP applications requires a thorough understanding of potential long term physical and chemical changes that may occur during service. While these components are generally fabricated from simple metallic systems such as copper, nickel and nickel alloys, the electroplating process used to form them creates microstructural features which differ from those found in conventional (e.g. ingot metallurgy) processing of such materials. Physical changes in non-equilibrium microstructures may occur due to long term exposure to temperatures sufficient to permit atomic and vacancy mobility. Chemical changes, particularly at the surfaces of LIGA parts, may occur in the presence of gaseous chemical species (e.g. water vapor, HE off-gassing compounds) and contact with other metallic structures. In this study, we have characterized the baseline microstructure of several nickel-based materials that are used to fabricate LIGA structures. Solute content and distribution was found to have a major effect on the electroplated microstructures. Microstructural features were correlated to measurements of hardness and tensile strength. Dormancy testing was conducted on one of the baseline compositions, nickel-sulfamate. Groups of specimens were exposed to controlled thermal cycles; subsequent examinations compared properties of 'aged' specimens to the baseline conditions. Results of our testing indicate that exposure to ambient temperatures (-54 C to 71 C) do not result in microstructural changes that might be expected to significantly effect mechanical performance. Additionally, no localized changes in surface appearance were found as a result of contact between electroplated parts.

  17. ENERGY FEEDBACK FROM X-RAY BINARIES IN THE EARLY UNIVERSE

    SciTech Connect (OSTI)

    Fragos, T.; Zezas, A. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)] [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Lehmer, B. D. [The Johns Hopkins University, Homewood Campus, Baltimore, MD 21218 (United States)] [The Johns Hopkins University, Homewood Campus, Baltimore, MD 21218 (United States); Naoz, S. [Institute for Theory and Computation, Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States)] [Institute for Theory and Computation, Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Basu-Zych, A., E-mail: tfragos@cfa.harvard.edu [NASA Goddard Space Flight Centre, Code 662, Greenbelt, MD 20771 (United States)

    2013-10-20T23:59:59.000Z

    X-ray photons, because of their long mean-free paths, can easily escape the galactic environments where they are produced, and interact at long distances with the intergalactic medium, potentially having a significant contribution to the heating and reionization of the early universe. The two most important sources of X-ray photons in the universe are active galactic nuclei (AGNs) and X-ray binaries (XRBs). In this Letter we use results from detailed, large scale population synthesis simulations to study the energy feedback of XRBs, from the first galaxies (z ? 20) until today. We estimate that X-ray emission from XRBs dominates over AGN at z ?> 6-8. The shape of the spectral energy distribution of the emission from XRBs shows little change with redshift, in contrast to its normalization which evolves by ?4 orders of magnitude, primarily due to the evolution of the cosmic star-formation rate. However, the metallicity and the mean stellar age of a given XRB population affect significantly its X-ray output. Specifically, the X-ray luminosity from high-mass XRBs per unit of star-formation rate varies an order of magnitude going from solar metallicity to less than 10% solar, and the X-ray luminosity from low-mass XRBs per unit of stellar mass peaks at an age of ?300 Myr and then decreases gradually at later times, showing little variation for mean stellar ages ?> 3 Gyr. Finally, we provide analytical and tabulated prescriptions for the energy output of XRBs, that can be directly incorporated in cosmological simulations.

  18. HIV-1 pre-mRNA commitment to Rev mediated export through PSF and Matrin 3

    SciTech Connect (OSTI)

    Kula, Anna; Gharu, Lavina [The Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34012 Trieste (Italy)] [The Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34012 Trieste (Italy); Marcello, Alessandro, E-mail: marcello@icgeb.org [The Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34012 Trieste (Italy)] [The Laboratory of Molecular Virology, International Centre for Genetic Engineering and Biotechnology (ICGEB), Padriciano 99, 34012 Trieste (Italy)

    2013-01-20T23:59:59.000Z

    Human immunodeficiency virus gene expression and replication are regulated at several levels. Incompletely spliced viral RNAs and full-length genomic RNA contain the RRE element and are bound by the viral trans-acting protein Rev to be transported out of the nucleus. Previously we found that the nuclear matrix protein MATR3 was a cofactor of Rev-mediated RNA export. Here we show that the pleiotropic protein PSF binds viral RNA and is associated with MATR3. PSF is involved in the maintenance of a pool of RNA available for Rev activity. However, while Rev and PSF bind the viral pre-mRNA at the site of viral transcription, MATR3 interacts at a subsequent step. We propose that PSF and MATR3 define a novel pathway for RRE-containing HIV-1 RNAs that is hijacked by the viral Rev protein.

  19. HIV-1 sequence variation between isolates from mother-infant transmission pairs

    SciTech Connect (OSTI)

    Wike, C.M.; Daniels, M.R.; Furtado, M.; Wolinsky, M.; Korber, B.; Hutto, C.; Munoz, J.; Parks, W.; Saah, A.

    1991-12-31T23:59:59.000Z

    To examine the sequence diversity of human immunodeficiency virus type 1 (HIV-1) between known transmission sets, sequences from the V3 and V4-V5 region of the env gene from 4 mother-infant pairs were analyzed. The mean interpatient sequence variation between isolates from linked mother-infant pairs was comparable to the sequence diversity found between isolates from other close contacts. The mean intrapatient variation was significantly less in the infants` isolates then the isolates from both their mothers and other characterized intrapatient sequence sets. In addition, a distinct and characteristic difference in the glycosylation pattern preceding the V3 loop was found between each linked transmission pair. These findings indicate that selection of specific genotypic variants, which may play a role in some direct transmission sets, and the duration of infection are important factors in the degree of diversity seen between the sequence sets.

  20. HIV-1 sequence variation between isolates from mother-infant transmission pairs

    SciTech Connect (OSTI)

    Wike, C.M.; Daniels, M.R.; Furtado, M.; Wolinsky, M.; Korber, B.; Hutto, C.; Munoz, J.; Parks, W.; Saah, A.

    1991-01-01T23:59:59.000Z

    To examine the sequence diversity of human immunodeficiency virus type 1 (HIV-1) between known transmission sets, sequences from the V3 and V4-V5 region of the env gene from 4 mother-infant pairs were analyzed. The mean interpatient sequence variation between isolates from linked mother-infant pairs was comparable to the sequence diversity found between isolates from other close contacts. The mean intrapatient variation was significantly less in the infants' isolates then the isolates from both their mothers and other characterized intrapatient sequence sets. In addition, a distinct and characteristic difference in the glycosylation pattern preceding the V3 loop was found between each linked transmission pair. These findings indicate that selection of specific genotypic variants, which may play a role in some direct transmission sets, and the duration of infection are important factors in the degree of diversity seen between the sequence sets.

  1. aspects early stages: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ryblewski 2012-07-03 104 A three stage model for the inner engine of Gamma Ray Burst: Prompt emission and early afterglow Astrophysics (arXiv) Summary: We propose a new model...

  2. albicans early stage: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Last Page Topic Index 101 A three stage model for the inner engine of Gamma Ray Burst: Prompt emission and early afterglow Astrophysics (arXiv) Summary: We propose a new model...

  3. amp inducible early: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    shows the Bode magnitude plots for both VoVi and A (j). The figure shows Leach Jr.,W. Marshall 125 Original article Role of the uterus in early regression of corpora lutea...

  4. Early remodeling of the neocortex upon episodic memory encoding

    E-Print Network [OSTI]

    Ericsson, M.

    Understanding the mechanisms by which long-term memories are formed and stored in the brain represents a central aim of neuroscience. Prevailing theory suggests that long-term memory encoding involves early plasticity ...

  5. Commissioning and early experiments of the PHELIX facility

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    009-3855-7 Commissioning and early experiments of the PHELIXthe recent years, the commissioning and operation of high-paper, we report on the commissioning of the PHELIX facility

  6. Final Report Early Evaluation of a Second Generation Information

    E-Print Network [OSTI]

    ........................................................................................................................ 4-2 4.3. Energy Management Control SystemsFinal Report Early Evaluation of a Second Generation Information Monitoring and Diagnostic System........................................................................................................ 4-4 5. Use of the Information Monitoring and Diagnostic System

  7. The Construction of Early Modernity in Spanish Film 

    E-Print Network [OSTI]

    Zarate Casanova, Miguel Angel

    2011-10-21T23:59:59.000Z

    The Construction of Early Modernity in Spanish Film. (August 2011) Miguel Angel Zarate Casanova, B.A. (Licenciatura), Complutense University at Madrid; M.A. (Diploma de Estudios Avanzados), Autonoma University at Madrid Chair of Advisory Committee: Dr. Richard K...

  8. Growing Up in Scotland: Pregnancy, Birth and Early Parenting 

    E-Print Network [OSTI]

    Government, Scottish

    2007-01-08T23:59:59.000Z

    The Growing Up in Scotland study ( GUS) is an important new longitudinal research project aimed at tracking the lives of a cohort of Scottish children from the early years, through childhood and beyond. Its principal aim is to provide information...

  9. 8.286 The Early Universe, Spring 2004

    E-Print Network [OSTI]

    Guth, Alan

    The Early Universe provides an introduction to modern cosmology. The first half deals with the development of the big-bang theory from 1915 to 1980, and latter half with recent impact of particle theory.

  10. College of Education IEC Interdisciplinary Early Childhood Education

    E-Print Network [OSTI]

    MacAdam, Keith

    College of Education IEC Interdisciplinary Early Childhood Education KEY: # = new course * = course changed = course dropped University of Kentucky 2013-2014 Undergraduate Bulletin 1 IEC 120 INTRODUCTION. IEC 255 CHILD DEVELOPMENT. (3) Anoverviewofthevariousaspectsofdevelopment

  11. Data Analysis of Early Fuel Cell Market Demonstrations (Presentation)

    SciTech Connect (OSTI)

    Kurtz, J.; Ramsden, T.; Wipke, K.; Sprik, S.

    2009-11-17T23:59:59.000Z

    Presentation about early fuel cell markets, the National Renewable Energy Laboratory's Hydrogen Secure Data Center and its role in data analysis and demonstrations, and composite data products, and results reported to multiple stakeholders.

  12. The early planning and development of Oklahoma City

    E-Print Network [OSTI]

    Humphreys, Blair D. (Blair David)

    2009-01-01T23:59:59.000Z

    An analysis of the planning, development, and implementation of Oklahoma City's Grand Boulevard. In the early days of 1909, a plan emerged to build an expansive parks and boulevard system to encircle Oklahoma City. Such ...

  13. Early Islamic architecture in Iran (637-1059) 

    E-Print Network [OSTI]

    Anisi, Alireza

    2008-01-01T23:59:59.000Z

    This thesis discusses the architecture of early Islamic Iran (16-450/637-1059). To better understand the architectural history of this period, it is necessary to specify in detail how it took shape and to describe its ...

  14. Structured Regions of Alpha-synuclein Fibrils Include the Early...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    diseases. Three single point mutations in the AS gene, as well as multiplication of the wild-type (WT) AS allele, have been previously identified in families with early-onset PD....

  15. The Atlas3D Project - XXX. Star formation histories and stellar population scaling relations of early-type galaxies

    E-Print Network [OSTI]

    McDermid, Richard M; Blitz, Leo; Bournaud, Frederic; Bureau, Martin; Cappellari, Michele; Crocker, Alison F; Davies, Roger L; Davis, Timothy A; de Zeeuw, P T; Duc, Pierre-Alain; Emsellem, Eric; Khochfar, Sadegh; Krajnovic, Davor; Kuntschner, Harald; Morganti, Raffaella; Naab, Thorsten; Oosterloo, Tom; Sarzi, Marc; Scott, Nicholas; Serra, Paolo; Weijmans, Anne-Marie; Young, Lisa M

    2015-01-01T23:59:59.000Z

    We present the stellar population content of early-type galaxies from the Atlas3D survey. Using spectra integrated within apertures covering up to one effective radius, we apply two methods: one based on measuring line-strength indices and applying single stellar population (SSP) models to derive SSP-equivalent values of stellar age, metallicity, and alpha enhancement; and one based on spectral fitting to derive non-parametric star-formation histories, mass-weighted average values of age, metallicity, and half-mass formation timescales. Using homogeneously derived effective radii and dynamically-determined galaxy masses, we present the distribution of stellar population parameters on the Mass Plane (M_JAM, Sigma_e, R_maj), showing that at fixed mass, compact early-type galaxies are on average older, more metal-rich, and more alpha-enhanced than their larger counterparts. From non-parametric star-formation histories, we find that the duration of star formation is systematically more extended in lower mass obje...

  16. Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibitors of Diabetes Complications

    SciTech Connect (OSTI)

    Nagai, Rhoji; Murray, David B.; Metz, Thomas O.; Baynes, John

    2012-03-01T23:59:59.000Z

    Advanced glycation or glycoxidation end-products (AGE) increase in tissue proteins with age, and their rate of accumulation is increased in diabetes, nephropathy and inflammatory diseases. AGE inhibitors include a range of compounds that are proposed to act by trapping carbonyl and dicarbonyl intermediates in AGE formation. However, some among the newer generation of AGE inhibitors lack reactive functional groups that would trap reaction intermediates, indicating an alternative mechanism of action. We propose that AGE inhibitors function primarily as chelators, inhibiting metal-catalyzed oxidation reactions. The AGE-inhibitory activity of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers is also consistent with their chelating activity. Finally, compounds described as AGE breakers, or their hydrolysis products, also have strong chelating activity, suggesting that these compounds also act through their chelating activity. We conclude that chelation is the common, and perhaps the primary, mechanism of action of AGE inhibitors and breakers, and that chronic, mild chelation therapy should prove useful in treatment of diabetes and age-related diseases characterized by oxidative stress, inflammation and increased chemical modification of tissue proteins by advanced glycoxidation and lipoxidation end-products.

  17. Early Alert System: Where Faculty Advising Meets First-Year Student Success

    E-Print Network [OSTI]

    ) Tutoring Comprehensive Learning Assistance Academic Advising Center Early Warning System Freshman Sciences #12;Advantages to Involving Faculty Advisors in Early Warning System Program and course expertise and Environmental Sciences #12;Early Warning Systems Institutional Constraints Prohibited Using Third Party Vendor

  18. Experimental investigations of photochemically-generated organic aerosols and applications to early Earth and Mars

    E-Print Network [OSTI]

    Chu, Emily Faye

    2013-01-01T23:59:59.000Z

    faint early Sun, Aust. J. Earth Sci. , 59(2), 167–176, doi:the atmosphere of early Earth, J. Geophys. Res. , 105(E5),haze on Titan and the early Earth, Proc. Natl. Acad. Sci.

  19. Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1

    SciTech Connect (OSTI)

    Lee, Ho-Hsien [Arizona State Univ., Tempe, AZ (United States); Cherni, Irene [Arizona State Univ., Tempe, AZ (United States); Yu, Hong Qi [Arizona State Univ., Tempe, AZ (United States); Fromme, Raimund [Arizona State Univ., Tempe, AZ (United States); Doran, Jeffrey D. [Arizona State Univ., Tempe, AZ (United States); Grotjohann, Ingo [Arizona State Univ., Tempe, AZ (United States); Mittman, Michele [Arizona State Univ., Tempe, AZ (United States); Basu, Shibom [Arizona State Univ., Tempe, AZ (United States); Deb, Arpan [Arizona State Univ., Tempe, AZ (United States); Dörner, Katerina [Arizona State Univ., Tempe, AZ (United States); Aquila, Andrew [Center for Free-Electron Laser Science, Hamburg (Germany); Barty, Anton [Center for Free-Electron Laser Science, Hamburg (Germany); Boutet, Sébastien [SLAC National Accelerator Laboratory, Menlo Park, CA (United States); Chapman, Henry N. [Center for Free-Electron Laser Science, Hamburg (Germany); Univ. of Hamburg, Hamburg (Germany); Doak, R. Bruce [Arizona State Univ., Tempe, AZ (United States); Hunter, Mark S. [Arizona State Univ., Tempe, AZ (United States); James, Daniel [Arizona State Univ., Tempe, AZ (United States); Kirian, Richard A. [Center for Free-Electron Laser Science, Hamburg (Germany); Arizona State Univ., Tempe, AZ (United States); Kupitz, Christopher [Arizona State Univ., Tempe, AZ (United States); Lawrence, Robert M. [Arizona State Univ., Tempe, AZ (United States); Liu, Haiguang [Arizona State Univ., Tempe, AZ (United States); Nass, Karol [Center for Free-Electron Laser Science, Hamburg (Germany); Univ. of Hamburg, Hamburg (Germany); Schlichting, Ilme [Max-Planck-Institut fur medizinische, Heidelberg (Germany); Schmidt, Kevin E. [Arizona State Univ., Tempe, AZ (United States); Seibert, M. Marvin [SLAC National Accelerator Lab., Menlo Park, CA (United States); Shoeman, Robert L. [Max-Planck-Institut fur medizinische, Heidelberg (Germany); Spence, John C. H. [Arizona State Univ., Tempe, AZ (United States); Stellato, Francesco [Center for Free-Electron Laser Science, Hamburg (Germany); Weierstall, Uwe [Arizona State Univ., Tempe, AZ (United States); Williams, Garth J. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Yoon, Chunhong [Center for Free-Electron Laser Science, Hamburg (Germany); European XFEL GmbH, Hamburg (Germany); Wang, Dingjie [Arizona State Univ., Tempe, AZ (United States); Zatsepin, Nadia A. [Arizona State Univ., Tempe, AZ (United States); Hogue, Brenda G. [Arizona State Univ., Tempe, AZ (United States); Matoba, Nobuyuki [Arizona State Univ., Tempe, AZ (United States); Fromme, Petra [Arizona State Univ., Tempe, AZ (United States); Mor, Tsafrir S. [Arizona State Univ., Tempe, AZ (United States)

    2014-09-01T23:59:59.000Z

    CTB-MPR is a fusion protein between the B subunit of cholera toxin (CTB) and the membrane-proximal region of gp41 (MPR), the transmembrane envelope protein ofHuman immunodeficiency virus 1(HIV-1), and has previously been shown to induce the production of anti-HIV-1 antibodies with antiviral functions. To further improve the design of this candidate vaccine, X-ray crystallography experiments were performed to obtain structural information about this fusion protein. Several variants of CTB-MPR were designed, constructed and recombinantly expressed inEscherichia coli. The first variant contained a flexible GPGP linker between CTB and MPR, and yielded crystals that diffracted to a resolution of 2.3?Å, but only the CTB region was detected in the electron-density map. A second variant, in which the CTB was directly attached to MPR, was shown to destabilize pentamer formation. A third construct containing a polyalanine linker between CTB and MPR proved to stabilize the pentameric form of the protein during purification. The purification procedure was shown to produce a homogeneously pure and monodisperse sample for crystallization. Initial crystallization experiments led to pseudo-crystals which were ordered in only two dimensions and were disordered in the third dimension. Nanocrystals obtained using the same precipitant showed promising X-ray diffraction to 5?Å resolution in femtosecond nanocrystallography experiments at the Linac Coherent Light Source at the SLAC National Accelerator Laboratory. The results demonstrate the utility of femtosecond X-ray crystallography to enable structural analysis based on nano/microcrystals of a protein for which no macroscopic crystals ordered in three dimensions have been observed before.

  20. Study of Early Universe in an M Theoretic Model

    E-Print Network [OSTI]

    Samrat Bhowmick

    2012-01-27T23:59:59.000Z

    In this thesis we study early universe in the frame work of M theory. In particular We assume that the early universe is homogeneous, anisotropic, and is dominated by the mutually BPS 22'55' intersecting branes of M theory. We find that, asymptotically, three spatial directions expand to infinity and the remaining spatial directions reach stabilised values. We give a physical description of the stabilisation mechanism.

  1. Impedance measurements for the early warning detection of epileptic seizures

    E-Print Network [OSTI]

    Glass, Michael Scott

    1989-01-01T23:59:59.000Z

    Chair of Advisory Committee: Dr. Gerald Miller A two electrode impedance measurement system was designed and tested as a detection device for the early warning of epileptic seizures. Previous methods have used four electrode impedance measurement... concentration of the medium. Miller and Gerber recently introduced the technique of using impedance measurements in the ECS for the early warning detection of epileptic seizures [12]. The impedance measurement system consisted of a probe with four...

  2. CMS experiment at the LHC: Commissioning and early physics

    E-Print Network [OSTI]

    A. Safonov

    2010-03-21T23:59:59.000Z

    The CMS collaboration used the past year to greatly improve the level of detector readiness for the first collisions data. The acquired operational experience over this year, large gains in understanding the detector and improved preparedness for early physics will be instrumental in minimizing the time from the first collisions to first LHC physics. The following describes the status of the CMS experiment and outlines early physics plans with the first LHC data.

  3. Superstring dominated early universe and epoch dependent gauge coupling

    E-Print Network [OSTI]

    A. K. Chaudhuri

    1997-06-13T23:59:59.000Z

    We have explored the possibility that the universe at very early stage was dominated by (macroscopic) heterotic strings. We have found that the dimensionless parameter $G\\mu$ for the heterotic strings varies from $10^{-2}$ to $10^{-4}$ as the universe evolve from the matter dominance to radiation dominance. This led to the interesting consequence of epoch dependent gauge coupling constant. The gauge coupling constant at early times was found to be much stronger than the present strong interaction.

  4. A strontium and neodymium isotopic study of Apollo 17 high-Ti mare basalts: Resolution of ages, evolution of magmas, and origins of source heterogeneities

    SciTech Connect (OSTI)

    Paces, J.B.; Neal, C.R.; Taylor, L.A. (Univ. of Tennessee, Knoxville (United States)); Nakai, Shun'ichi; Halliday, A.N.; Lee, D.C. (Univ. of Michigan, Ann Arbor (United States))

    1991-07-01T23:59:59.000Z

    A combined Sr and Nd isotopic study of 15 Apollo 17 high-Ti mare basalts was undertaken to investigate geochronological and compositional differences between previously identified magma types (A, B1, B2, and C). Whole-rock and mineral separates for one of the least-evolved Type B1 basalts, 70139, yield Sm-Nd and Rb-Sr isochron ages of 3.71 {plus minus} 0.12 Ga and 3.65 {plus minus} 0.07 Ga and a Rb-Sr isochron age of 3.67 {plus minus} 0.10 Ga. Although these two ages are non-resolvable by themselves, compilation of all available geochronological data allows resolution of Type A and B1/B2 ages at high levels of confidence (> 99%). The most reliably dated samples, classified according to their geochemical type, yield weighted average ages of 3.75 {plus minus} 0.02 Ga for Type A (N = 4) and 3.69 {plus minus} 0.02 Ga for Type B1/B2 (N = 3) basalts. Insufficient geochronological data are available to place the rare, Type C basalts within this stratigraphy. The authors propose that age differences correlate with geochemical magma type, and that early magmatism was dominated by eruption of Type A basalts while later activity was dominated by effusion of Type B1 and B2 basalts.

  5. Spectro-Microscopic Measurements of Carbonaceous Aerosol Aging...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of Carbonaceous Aerosol Aging in Central California. Abstract: Carbonaceous aerosols are responsible for large uncertainties in climate models, degraded visibility, and...

  6. aging colloidal glass: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Matter (arXiv) Summary: We use confocal microscopy to directly visualize the dynamics of aging colloidal glasses. We prepare a colloidal suspension at high density, a...

  7. aged patients usefulness: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (6-month old, 12-month old, and adult) based on auditory event-related potentials Reilly, James P. 34 USING OBJECTIVE CRITERIA AND MULTIPLE REGRESSION MODELS FOR AGE...

  8. accelerated aging studies: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the nominal one, increasing background and pile-up event probability. This requires detector performances which are currently under study in intensive R&D activities. Aging is...

  9. age spectrum epidemiology: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of a young supernova. We associate this break with the phenomenon of synchrotron aging of radiating electrons. From the break in the spectrum we calculate the magnetic field...

  10. aging aircraft wiring: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    energy of the particle detected. Nevertheless, many factors can contribute to detector aging effects which are visible in a loss of gain caused by deposition of contaminants on...

  11. age xenocrystic zircons: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    zircon age populations suggest that deposition of the extensive 1 km-thick clastic sequence at the base of the cover succession commenced in latest Neoproterozoic and terminated...

  12. age experimental analysis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: , by improving the seismic hazard evaluation using probabilistic seismic hazard assessment (PSHA) methodsSeismic vulnerability assessment to slight dam- age...

  13. Aging Impairs Myocardial Fatty Acid and Ketone Oxidation and...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    that aging modifies substrate utilization and alters insulin sensitivity in mouse heart when provided multiple substrates. In vivo cardiac function was measured with...

  14. age metamorphic history: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (TRFs) shorten predictably with age in a particular tissue Vleck, Carol 11 Thermal and Impact History of the H Chondrite Parent Asteroid during Metamorphism: Constraints from...

  15. Schistosomiasis models with density dependence and age of ...

    E-Print Network [OSTI]

    2002-04-08T23:59:59.000Z

    type of validation concerning the new features being added and the extent to ... an age structure in the class of infected snails, since their cercarial production.

  16. age tumor size: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    alternate body arches, fin cartilage 422 AGE AND GROWTH OF SKIPJACK TUNA, KATSUWONUS PELAMIS, AND YELLOWFIN TUNA, THUNNUS ALBACARES, AS INDICATED Environmental Sciences and...

  17. Influence of Aging and Environment on Nanoparticle Chemistry...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of cerium in cerium oxide nanoparticles is studied in detail. The influence of synthesis medium, aging time and local environment on the oxidation state switching, between +3 and...

  18. Bacteria and the Aging and Longevity of Caenorhabditis elegans

    E-Print Network [OSTI]

    Kim, Dennis H.

    The molecular genetic analysis of longevity of Caenorhabditis elegans has yielded fundamental insights into evolutionarily conserved pathways and processes governing the physiology of aging. Recent studies suggest that ...

  19. aged adults: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The "Aging in Place" project strives to delay taking that first step away from the family home. Through the careful placement of technological support we believe older...

  20. Notes on Groundwater Age in Forward and Inverse Modeling

    E-Print Network [OSTI]

    Ginn, Timothy R.; Haeri, Hanieh; Massoudieh, Arash; Foglia, Laura

    2009-01-01T23:59:59.000Z

    from radiocarbon dating of groundwater and numerical ?ow andReply to “Comment on groundwater age, life expectancy andanalysis of regional groundwater ?ow. 2. Effect of water-

  1. age care managers: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 Managing Prosperity: Estate and Retirement Planning for All Ages Planning for Long-Term Health Care Computer Technologies and Information Sciences Websites Summary: 15 million by...

  2. Readings in Common: Assimilation and Interpretive Authority in Early Modern Spain

    E-Print Network [OSTI]

    Kimmel, Seth Ross

    2010-01-01T23:59:59.000Z

    Practice in Early Modern Spain. Minneapolis: University of1993. Harvey, L. P. Muslims in Spain, 1500-1614. Chicago:of Religion in Early Modern Spain. Princeton: Princeton

  3. Attitudes to ageing : a systematic review of attitudes to ageing and mental health, and a cross-sectional analysis of attitudes to ageing and quality of life in older adults 

    E-Print Network [OSTI]

    Long, Sarah Charlotte May

    2014-07-01T23:59:59.000Z

    This thesis portfolio examines attitudes to ageing in older adults, and explores the impact that attitudes to ageing have on mental health status and quality of life. Attitudes to ageing are becoming more widely measured ...

  4. Theoretical foundation for measuring the groundwater age distribution.

    SciTech Connect (OSTI)

    Gardner, William Payton; Arnold, Bill Walter

    2014-01-01T23:59:59.000Z

    In this study, we use PFLOTRAN, a highly scalable, parallel, flow and reactive transport code to simulate the concentrations of 3H, 3He, CFC-11, CFC-12, CFC-113, SF6, 39Ar, 81Kr, 4He and themean groundwater age in heterogeneous fields on grids with an excess of 10 million nodes. We utilize this computational platform to simulate the concentration of multiple tracers in high-resolution, heterogeneous 2-D and 3-D domains, and calculate tracer-derived ages. Tracer-derived ages show systematic biases toward younger ages when the groundwater age distribution contains water older than the maximum tracer age. The deviation of the tracer-derived age distribution from the true groundwater age distribution increases with increasing heterogeneity of the system. However, the effect of heterogeneity is diminished as the mean travel time gets closer the tracer age limit. Age distributions in 3-D domains differ significantly from 2-D domains. 3D simulations show decreased mean age, and less variance in age distribution for identical heterogeneity statistics. High-performance computing allows for investigation of tracer and groundwater age systematics in high-resolution domains, providing a platform for understanding and utilizing environmental tracer and groundwater age information in heterogeneous 3-D systems. Groundwater environmental tracers can provide important constraints for the calibration of groundwater flow models. Direct simulation of environmental tracer concentrations in models has the additional advantage of avoiding assumptions associated with using calculated groundwater age values. This study quantifies model uncertainty reduction resulting from the addition of environmental tracer concentration data. The analysis uses a synthetic heterogeneous aquifer and the calibration of a flow and transport model using the pilot point method. Results indicate a significant reduction in the uncertainty in permeability with the addition of environmental tracer data, relative to the use of hydraulic measurements alone. Anthropogenic tracers and their decay products, such as CFC11, 3H, and 3He, provide significant constraint oninput permeability values in the model. Tracer data for 39Ar provide even more complete information on the heterogeneity of permeability and variability in the flow system than the anthropogenic tracers, leading to greater parameter uncertainty reduction.

  5. Challenges for Lithuania: Ignalina NPP Early Closure

    SciTech Connect (OSTI)

    Teskeviciene, Birute [Ministry of Economy, Gedimino pr. 38/2, Vilnius, LT-01104 (Lithuania); Harrison, Peter [Central Project Management Agency, S. Konarskio 13, Vilnius, LT-03109 (Lithuania)

    2008-01-15T23:59:59.000Z

    As a condition of accession into the European Union (EU), Lithuania is committed to the closure and decommissioning of Ignalina NPP comprising two RBMK-1500 reactor units (Fig. 1). It was agreed in a special protocol to the Accession Treaty that, in return for adequate EU financial assistance, Unit 1 would be closed before 2005 and Unit 2 by the end of 2009. The first unit was duly shut down on December 31, 2004. Lithuania, which has borders with Russia (Kaliningrad territory), Poland, Latvia and Belarus, spent fifty years as part of the Soviet Union and was deeply integrated into its economy and electrical infrastructure. At the break-up of the USSR, Lithuania inherited electricity generating capacity designed to supply the north-west region including ownership of Ignalina NPP located in the north-east of the country. Ignalina NPP Unit 1 was commissioned in 1983, Unit 2 in 1987; the planned lifespan of each unit was 30 years. Construction of a third unit was started but never completed. Since Lithuania became independent in 1990, Ignalina NPP has typically contributed more than 70% of national power supply. The town of Visaginas (population approx. 30,000) was purpose built to serve the plant and staff were brought in from throughout the USSR. With 3200 direct employees, Ignalina NPP remains by far the largest employer. Although there are pockets of Russian-language speakers in communities throughout Lithuania, Visaginas is the only example on a whole-town scale. Thus closure of Ignalina NPP within the restricted timescale required by the EU Accession Treaty commitment set an exceptional challenge to Lithuania. However, since the preparatory phase of decommissioning started in 2000, notable progress has been made, experience gained and lessons learnt. At present Unit 1 remains partially fueled in a state of care and maintenance. Partly burnt fuel is being transferred from Unit 1 to Unit 2 for further irradiation in order to minimize the commitment of new fuel thereby reducing operating costs and the final quantity of spent fuel. Design and construction of the facilities for spent fuel storage, waste processing and free-release is ongoing. The siting of the Near Surface Repository is now in the final stages of approval and construction of the landfill facility is under tendering. In order to facilitate the approval process and minimize the transport of waste, both disposal facilities will be within the boundary of the NPP site. Approximately 450 staff are employed at the shutdown Unit 1 for the safe maintenance of essential systems. The total staffing level at the plant is currently being reduced by around 200 each year, with a larger release to take place at the closure of Unit 2. It is envisaged that 2000 staff will be required for the dismantling operations. Although Ignalina NPP is still in the early stages of closure and decommissioning, some important lessons have already been learnt: Firstly, the importance considering social and financial issues as well as technical factors in deciding the decommissioning strategy. This should be done before the preparation is started of the FDP. The same broad consideration should also be given to the economic restructuring of the local area. Consultation is necessary with local and national authorities, and other stakeholders up to ensure a common vision. At Ignalina NPP it was considered essential to staff morale and the maintenance of a strong safety culture to guarantee the special social and employment benefits to dismissed staff in law [9]. At the same time, measures were also adopted to encourage certain key personnel to remain at the plant until closure. The case of Lithuania, which at independence had no legislative framework or management infrastructure for radioactive waste, may be exceptional; however, for all decommissioning projects it is necessary to have, from the outset, a clear strategy on waste storage and disposal. Finally, coordination at all levels must be assured, especially with the involvement of the nuclear regulators and other regulatory authorities, t

  6. Localized or Systemic {italic In Vivo} Heat-Inactivation of Human Immunodeficiency Virus (HIV): A Mathematical Analysis

    SciTech Connect (OSTI)

    Pennypacker, Carl R.; Perelson, A.S.; Nys, N.; Nelson, G.; Sessler, D.I.

    1993-12-15T23:59:59.000Z

    Temperatures as low as 42 C, maintained for a little as 25 minutes, inactivate {approx}25% of HIV. Furthermore, human immunodeficiency virus (HIV)-infected T-cells are more sensitive to heat than healthy lymphocytes and susceptibility increases when the cells are pre-sensitized by exposure to tumor necrosis factor. Thus, induction of a whole-body hyperthermia, or hyperthermia specifically limited to tissues having a high viral load, are potential antiviral therapies for acquired immunodeficiency disease (AIDS). Accordingly, we incorporated therapeutic hyperthermia into an existing mathematical model which evaluates the interaction between HIV and CD4{sup +} T cells. Given the assumptions and limitations of this model, the results indicate that a daily therapy, reducing the population of actively infected cells by 40% or infectious virus by 50%, would effectively reverse the depletion of T cells. In contrast, a daily reduction of 20% of either actively infected cells or infectious virus would have a marginal effect. However, reduction by 20% of both actively infected cells and infectious virus could restore T cell numbers, assuming that permanent damage had not been inflicted on the thymus. Whole-body hyperthermia seems unlikely to be clinically useful, unless it can be induced non-invasively without general anesthesia. In contrast, heating directed specifically to areas of viral concentration may be effective and have a suitable risk/benefit ratio.

  7. THE ROLE OF AGING AND ONCE-THROUGH-COOLED POWER

    E-Print Network [OSTI]

    CALIFORNIA ENERGY COMMISSION THE ROLE OF AGING AND ONCE-THROUGH-COOLED POWER PLANTS IN CALIFORNIA Nyberg, Darryl Metz, Connie Leni. 2009. The Role of Aging and Once-Through-Cooled Power Plants .......................................9 The Performance of Once-Through-Cooled Power Plants 2002

  8. AGEING NORTH AMERICAN LANDBIRDS BY MOLT LIMITS AND PLUMAGE CRITERIA

    E-Print Network [OSTI]

    DeSante, David F.

    TO THE IDENTIFICATION GUIDE TO NORTH AMERICAN BIRDS, PART I Dan Froehlich Slate Creek Press #12;AGEING NORTH AMERICAN TO NORTH AMERICAN BIRDS, PART I Dan Froehlich Slate Creek Press Bolinas, California #12;Ageing North by David F. DeSante, Peter Pyle, and Nicole Michel for Slate Creek Press, P.O. Box 219, Bolinas, California

  9. Communicating Coastal Risk Analysis in an Age of Climate Change

    E-Print Network [OSTI]

    Communicating Coastal Risk Analysis in an Age of Climate Change TR-11-04 Brian Blanton, John Mc in an Age of Climate Change Brian Blanton, John McGee, Oleg Kapeljushnik Renaissance Computing Institute of climate change complicates matters further. An immersive visualization environment integrating data from

  10. aging materials: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    aging materials First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Ageing and Rheology in Soft Materials...

  11. Asphalt Pavement Aging and Temperature Dependent Properties through a Functionally

    E-Print Network [OSTI]

    Paulino, Glaucio H.

    Asphalt Pavement Aging and Temperature Dependent Properties through a Functionally Graded ­ Verification ­ Concluding Remarks Part ­ II (Companion presentation) ­ Asphalt Pavements ­ Effect of Aging: Asphalt concrete pavements (Part II) E1 E2 E3 Eh 1 2 3 h #12;Graded Finite Elements Graded Elements

  12. Revised isotopic (40 Ar) age for the lamproite volcano of

    E-Print Network [OSTI]

    Utrecht, Universiteit

    Revised isotopic (40 Ar/39 Ar) age for the lamproite volcano of Cabezos Negros, Fortuna Basin (lamproites) of the Fortuna Basin in southeast Spain. This age is significantly older than earlier reported K. Because the volcanic rocks are intercalated in the stratigraphic sequence of the Fortuna Basin directly

  13. International Trade in Natural Gas: Golden Age of LNG?

    E-Print Network [OSTI]

    Gabrieli, John

    International Trade in Natural Gas: Golden Age of LNG? Yichen Du and Sergey Paltsev Report No. 271;1 International Trade in Natural Gas: Golden Age of LNG? Yichen Du* and Sergey Paltsev* Abstract The introduction of liquefied natural gas (LNG) as an option for international trade has created a market for natural gas where

  14. Czech Archaeologists in Uzbekistan Discover Bronze Age Irrigation System

    E-Print Network [OSTI]

    Cerveny, Vlastislav

    Czech Archaeologists in Uzbekistan Discover Bronze Age Irrigation System Compiled 20.11.2014 16 they discovered was settlements dating back to the Iron and Bronze Ages, including a well-preserved irrigation system. The Paschurt Valley is located in the south of Uzbekistan, a country which has become

  15. Lading of the Late Bronze Age ship at Uluburun 

    E-Print Network [OSTI]

    Lin, Shih-Han Samuel

    2012-08-29T23:59:59.000Z

    clear indication of a Late Bronze Age site. This find was of considerable interest as very little is known about seafaring, long distance trade, and ship construction during the Late Bronze Age, except for a glimpse provided by the Cape Gelidonya...

  16. Aging management guideline for commercial nuclear power plants-pumps

    SciTech Connect (OSTI)

    Booker, S.; Katz, D.; Daavettila, N.; Lehnert, D. [MDC-Ogden Environmental and Energy Services, Southfield, MI (United States)

    1994-03-01T23:59:59.000Z

    This Aging Management Guideline (AMG) describes recommended methods for effective detection and mitigation of age-related degradation mechanisms in BWR and PWR commercial nuclear power plant pumps important to license renewal. The intent of this AMG is to assist plant maintenance and operations personnel in maximizing the safe, useful life of these components. It also supports the documentation of effective aging management programs required under the License Renewal Rule 10 CFR Part 54. This AMG is presented in a manner that allows personnel responsible for performance analysis and maintenance to compare their plant-specific aging mechanisms (expected or already experienced) and aging management program activities to the more generic results and recommendations presented herein.

  17. EVOLUTION OF AGING AND LATE LIFE Casandra L. Rauser, Laurence D. Mueller,

    E-Print Network [OSTI]

    Rose, Michael R.

    551 18 EVOLUTION OF AGING AND LATE LIFE Casandra L. Rauser, Laurence D. Mueller, Michael Travisano of Aging Specific Population Genetic Hypotheses for Aging THE ROLE OF EXPERIMENTAL EVOLUTION IN TESTING HAMILTONIAN THEORIES OF AGING Laboratory Evolution of Aging Experimental Population Genetics of Aging

  18. An assessment of fire vulnerability for aged electrical relays

    SciTech Connect (OSTI)

    Vigil, R.A. [Sandia National Labs., Albuquerque, NM (United States)]|[Science and Engineering Associates, Inc., Albuquerque, NM (United States); Nowlen, S.P. [Sandia National Labs., Albuquerque, NM (United States)

    1995-03-01T23:59:59.000Z

    There has been some concern that, as nuclear power plants age, protective measures taken to control and minimize the impact of fire may become ineffective, or significantly less effective, and hence result in an increased fire risk. One objective of the Fire Vulnerability of Aged Electrical Components Program is to assess the effects of aging and service wear on the fire vulnerability of electrical equipment. An increased fire vulnerability of components may lead to an overall increase in fire risk to the plant. Because of their widespread use in various electrical safety systems, electromechanical relays were chosen to be the initial components for evaluation. This test program assessed the impact of operational and thermal aging on the vulnerability of these relays to fire-induced damage. Only thermal effects of a fire were examined in this test program. The impact of smoke, corrosive materials, or fire suppression effects on relay performance were not addressed in this test program. The purpose of this test program was to assess whether the fire vulnerability of electrical relays increased with aging. The sequence followed for the test program was to: identify specific relay types, develop three fire scenarios, artificially age several relays, test the unaged and aged relays in the fire exposure scenarios, and compare the results. The relays tested were Agastat GPI, General Electric (GE) HMA, HGA, and HFA. At least two relays of each type were artificially aged and at least two relays of each type were new. Relays were operationally aged by cycling the relay under rated load for 2,000 operations. These relays were then thermally aged for 60 days with their coil energized.

  19. PIXE, Micro-PIXE and RBS Analysis of Thermal Aged Rubber Material : On The Additives Behaviour Versus Aging Time

    E-Print Network [OSTI]

    Boyer, Edmond

    PIXE, Micro-PIXE and RBS Analysis of Thermal Aged Rubber Material : On The Additives Behaviour Villeurbanne Cedex-France. ABSTRACT PIXE, micro-PIXE and RBS techniques were employed to monitor the behaviour of the rubber material itself. Keywords : PIXE, micro-PIXE, RBS, Rubber, Thermal Aging, Segregation, Additives

  20. An alternative approach for the Istanbul earthquake early warning system Hakan Alcik a

    E-Print Network [OSTI]

    Wu, Yih-Min

    An alternative approach for the Istanbul earthquake early warning system Hakan Alcik a , Oguz Ozelb occur around Istanbul region, an earthquake early warning system has been established in 2002 of Istanbul earthquake early warning system (IEEWS) for giving early warning of a damaging earthquake