National Library of Energy BETA

Sample records for highly toxic herbicides

  1. Kudzu (Pueraria montana) community responses to herbicides, burning, and high-density loblolly pine

    SciTech Connect (OSTI)

    T.B. Harrington; L.T. Rader-Dixon; J.W. Taylor, Jr.

    2003-11-01

    Kudzu is an aggressive, nonnative vine that currently dominates an estimated 810,000 ha of mesic forest communities in the eastern United States. To test an integrated method of weed control, abundances of kudzu and other plant species were compared during 4 yr after six herbicide treatments (clopyralid, triclopyr, metsulfuron, picloram 1 2,4-D, tebuthiuron, and a nonsprayed check), in which loblolly pines were planted at three densities (0, 1, and 4 seedlings m22) to induce competition and potentially delay kudzu recovery. This split-plot design was replicated on each of the four kudzu-dominated sites near Aiken, SC. Relative light intensity (RLI) and soil water content (SWC) were measured periodically to identify mechanisms of interference among plant species. Two years after treatment (1999), crown coverage of kudzu averaged , 2% in herbicide plots compared with 93% in the nonsprayed check, and these differences were maintained through 2001, except in clopyralid plots where kudzu cover increased to 15%. In 2001, pine interference was associated with 33, 56, and 67% reductions in biomass of kudzu, blackberry, and herbaceous vegetation, respectively. RLI in kudzu-dominated plots (4 to 15% of full sun) generally was less than half that of herbicide-treated plots. SWC was greatest in tebuthiuron plots, where total vegetation cover averaged 26% compared with 77 to 111% in other plots. None of the treatments eradicated kudzu, but combinations of herbicides and induced pine competition delayed its recovery.

  2. Comparing Metal Leaching and Toxicity from High pH, Low pH, and High Ammonia Fly Ash

    SciTech Connect (OSTI)

    Palumbo, Anthony Vito; Phillips, Jana Randolph; Fagan, Lisa Anne; Drake, Meghan M; Ruther, Rose Emily; Fisher, L. Suzanne; Amonette, J. E.

    2007-01-01

    Previous work with both class F and class C fly ash indicated minimal leaching from most fly ashes tested. However, the addition of NOx removal equipment might result in higher levels of ammonia in the fly ash. We have recently been testing fly ash with a wide range of pH (3.7-12.4) originating from systems with NOx removal equipment. Leaching experiments were done using dilute CaCl2 solutions in batch and columns and a batch nitric acid method. All methods indicated that the leaching of heavy metals was different in the highest ammonia sample tested and the high pH sample. However, toxicity testing with the Microtox system has indicated little potential toxicity in leachates except for the fly ash at the highest pH (12.4). When the leachate from the high pH fly ash was neutralized, toxicity was eliminated.

  3. Comparing metal leaching and toxicity from high pH, low pH, and high ammonia fly ash

    SciTech Connect (OSTI)

    Palumbo, Anthony V.; Tarver, Jana R.; Fagan, Lisa A.; McNeilly, Meghan S.; Ruther, Rose; Fisher, L. S.; Amonette, James E.

    2007-07-01

    Previous work with both class F and class C fly ash indicated minimal leaching from most fly ashes tested. However, the addition of NOx removal equipment might result in higher levels of ammonia in the fly ash. We have recently been testing fly ash with a wide range of pH (3.712.4) originating from systems with NOx removal equipment. Leaching experiments were done using dilute CaCl2 solutions in batch and columns and a batch nitric acid method. All methods indicated that the leaching of heavy metals was different in the highest ammonia sample tested and the high pH sample. However, toxicity testing with the Microtox* system has indicated little potential toxicity in leachates except for the fly ash at the highest pH (12.4). When the leachate from the high pH fly ash was neutralized, toxicity was eliminated.

  4. Forestry herbicide influences on biodiversity and wildlife habitats in Southern forests.

    SciTech Connect (OSTI)

    Miller, Karl V.

    2004-01-01

    Abstract In the southern United States, herbicide use continues to increase for timber management in commercial pine (Pinus spp.) plantations, for modifying wildlife habitats, and for invasive plant control. Several studies have reported that single applications of forestry herbicides at stand initiation have minor and temporary impacts on plant communities and wildlife habitat conditions, with some reports of enhanced habitat conditions for both game and nongame species. Due to the high resiliency of floral communities, plant species richness and diversity rebound rapidly after single herbicide treatments, with short- and long-term compositional shifts according to the selectivity and efficacy of the herbicide used. Recently, however, a shift to the Southeast in North American timber supplies has resulted in increased forest management intensity. Current site-preparation techniques rely on herbicide combinations, often coupled with mechanical treatments and >1 years of post-planting applications to enhance the spectrum and duration of vegetation control. This near-total control of associated vegetation at establishment and more rapid pine canopy closure, coupled with shortened and repeated rotations, likely will affect plant diversity and wildlife habitat quality. Development of mitigation methods at the stand and landscape levels will be required to minimize vegetative and wildlife impacts while allowing continued improvement in pine productivity. More uncertain are long-term impacts of increasing invasive plant occupation and the projected increase in herbicide use that will be needed to reverse this worsening situation. In addition, the potential of herbicides to meet wildlife management objectives in areas where traditional techniques have high social costs (e.g., prescribed fire) should be fully explored.

  5. Forestry herbicide influences on biodiversity and wildlife habitat in Southern forests.

    SciTech Connect (OSTI)

    Miller, Karl V.; Miller, James, H.

    2004-07-01

    Abstract In the southern United States, herbicide use continues to increase for timber management in commercial pine (Pinus spp.) plantations, for modifying wildlife habitats, and for invasive plant control. Several studies have reported that single applications of forestry herbicides at stand initiation have minor and temporary impacts on plant communities and wildlife habitat conditions, with some reports of enhanced habitat conditions for both game and nongame species. Due to the high resiliency of floral communities, plant species richness and diversity rebound rapidly after single herbicide treatments, with short- and long-term compositional shifts according to the selectivity and efficacy of the herbicide used. Recently, however, a shift to the Southeast in North American timber supplies has resulted in increased forest management intensity. Current site-preparation techniques rely on herbicide combinations, often coupled with mechanical treatments and >1 years of post-planting applications to enhance the spectrum and duration of vegetation control. This near-total control of associated vegetation at establishment and more rapid pine canopy closure, coupled with shortened and repeated rotations, likely will affect plant diversity and wildlife habitat quality. Development of mitigation methods at the stand and landscape levels will be required to minimize vegetative and wildlife impacts while allowing continued improvement in pine productivity. More uncertain are long-term impacts of increasing invasive plant occupation and the projected increase in herbicide use that will be needed to reverse this worsening situation. In addition, the potential of herbicides to meet wildlife management objectives in areas where traditional techniques have high social costs (e.g., prescribed fire) should be fully explored.

  6. Gender-specific reduction of hepatic Mrp2 expression by high-fat diet protects female mice from ANIT toxicity

    SciTech Connect (OSTI)

    Kong, Bo; Csanaky, Ivn L.; Aleksunes, Lauren M.; Patni, Meghan; Chen, Qi; Ma, Xiaochao; Jaeschke, Hartmut; Weir, Scott; Broward, Melinda; Klaassen, Curtis D.; University of Kansas Cancer Center, Kansas City, KS ; Guo, Grace L.

    2012-06-01

    Emerging evidence suggests that feeding a high-fat diet (HFD) to rodents affects the expression of genes involved in drug transport. However, gender-specific effects of HFD on drug transport are not known. The multidrug resistance-associated protein 2 (Mrp2, Abcc2) is a transporter highly expressed in the hepatocyte canalicular membrane and is important for biliary excretion of glutathione-conjugated chemicals. The current study showed that hepatic Mrp2 expression was reduced by HFD feeding only in female, but not male, C57BL/6J mice. In order to determine whether down-regulation of Mrp2 in female mice altered chemical disposition and toxicity, the biliary excretion and hepatotoxicity of the Mrp2 substrate, ?-naphthylisothiocyanate (ANIT), were assessed in male and female mice fed control diet or HFD for 4 weeks. ANIT-induced biliary injury is a commonly used model of experimental cholestasis and has been shown to be dependent upon Mrp2-mediated efflux of an ANIT glutathione conjugate that selectively injures biliary epithelial cells. Interestingly, HFD feeding significantly reduced early-phase biliary ANIT excretion in female mice and largely protected against ANIT-induced liver injury. In summary, the current study showed that, at least in mice, HFD feeding can differentially regulate Mrp2 expression and function and depending upon the chemical exposure may enhance or reduce susceptibility to toxicity. Taken together, these data provide a novel interaction between diet and gender in regulating hepatobiliary excretion and susceptibility to injury. -- Highlights: ? High-fat diet decreases hepatic Mrp2 expression only in female but not in male mice. ? HFD significantly reduces early-phase biliary ANIT excretion in female mice. ? HFD protects female mice against ANIT-induced liver injury.

  7. Gene encoding herbicide safener binding protein

    DOE Patents [OSTI]

    Walton, Jonathan D.; Scott-Craig, John S.

    1999-01-01

    The cDNA encoding safener binding protein (SafBP), also referred to as SBP1, is set forth in FIG. 5 and SEQ ID No. 1. The deduced amino acid sequence is provided in FIG. 5 and SEQ ID No. 2. Methods of making and using SBP1 and SafBP to alter a plant's sensitivity to certain herbicides or a plant's responsiveness to certain safeners are also provided, as well as expression vectors, transgenic plants or other organisms transfected with said vectors and seeds from said plants.

  8. EA-2013: Herbicide Application at Three Substations; Imperial County

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    (California), Maricopa and Yuma Counties (Arizona) | Department of Energy 13: Herbicide Application at Three Substations; Imperial County (California), Maricopa and Yuma Counties (Arizona) EA-2013: Herbicide Application at Three Substations; Imperial County (California), Maricopa and Yuma Counties (Arizona) SUMMARY Western Area Power Administration (Western) and the Bureau of Land Management (BLM) are jointly preparing an EA that analyzes the potential environmental impacts of Western's

  9. EA-2013: Herbicide Application at Three Substations; Imperial County

    Office of Environmental Management (EM)

    (California), Maricopa and Yuma Counties (Arizona) | Department of Energy 3: Herbicide Application at Three Substations; Imperial County (California), Maricopa and Yuma Counties (Arizona) EA-2013: Herbicide Application at Three Substations; Imperial County (California), Maricopa and Yuma Counties (Arizona) SUMMARY Western Area Power Administration (Western) and the Bureau of Land Management (BLM) prepared an EA that analyzes the potential environmental impacts of Western's proposed use of

  10. Toxic remediation

    DOE Patents [OSTI]

    Matthews, Stephen M. (Alamed County, CA); Schonberg, Russell G. (Santa Clara County, CA); Fadness, David R. (Santa Clara County, CA)

    1994-01-01

    What is disclosed is a novel toxic waste remediation system designed to provide on-site destruction of a wide variety of hazardous organic volatile hydrocarbons, including but not limited to halogenated and aromatic hydrocarbons in the vapor phase. This invention utilizes a detoxification plenum and radiation treatment which transforms hazardous organic compounds into non-hazardous substances.

  11. Leaching and persistence of herbicides for kudzu (Pueraria montana) control on pine regeneration sites

    SciTech Connect (OSTI)

    Berisford, Yvette, C.; Bush, Parshall, B.; Taylor, John, W.

    2006-03-01

    Kudzu is an exotic vine that threatens forests in the southeastern United States. It can climb, overtop, and subsequently kill new seedlings or mature trees. Herbicides are commonly used to control kudzu; however, eradication might require retreatment for 3 to 10 yr in young stands and 7 to 10 yr for mature stands. Clopyralid, picloram, triclopyr, metsulfuron, and tebuthiuron exert various degrees of control, depending on soil type, meteorological conditions, herbicide formulation, seasonal application, characteristics of the kudzu stand, and frequency and number of herbicide. Field residue data for soil or leachate are lacking for all of these herbicides when they are used in actual forest regeneration programs in the Coastal Plain. These data are needed to assess the relative potential for the herbicides to leach into groundwater or to move off-site into sensitive ecological areas of the Coastal Plain in which sandy soils predominate and the groundwater tends to be shallow. As part of an integrated pest management program to control kudzu on forest regeneration areas at the Savannah River Site near New Ellenton, SC, five herbicides were evaluated from the standpoints of herbicide leaching, kudzu control, and plant community development. Three herbicide chemical families were represented. This included pyridinecarboxylic acid herbicides (clopyralid, picloram 1 2,4-D, and triclopyr), a sulfonylurea herbicide (metsulfuron), and a substituted urea herbicide (tebuthiuron).

  12. Long-term Survival and Toxicity in Patients Treated With High-Dose Intensity Modulated Radiation Therapy for Localized Prostate Cancer

    SciTech Connect (OSTI)

    Spratt, Daniel E.; Pei, Xin; Yamada, Josh; Kollmeier, Marisa A.; Cox, Brett; Zelefsky, Michael J.

    2013-03-01

    Purpose: To report long-term survival and toxicity outcomes with the use of high-dose intensity modulated radiation therapy (IMRT) to 86.4 Gy for patients with localized prostate cancer. Methods and Materials: Between August 1997 and December 2008, 1002 patients were treated to a dose of 86.4 Gy using a 5-7 field IMRT technique. Patients were stratified by prognostic risk group based on National Comprehensive Cancer Network risk classification criteria. A total of 587 patients (59%) were treated with neoadjuvant and concurrent androgen deprivation therapy. The median follow-up for the entire cohort was 5.5 years (range, 1-14 years). Results: For low-, intermediate-, and high-risk groups, 7-year biochemical relapse-free survival outcomes were 98.8%, 85.6%, and 67.9%, respectively (P<.001), and distant metastasis-free survival rates were 99.4%, 94.1%, and 82.0% (P<.001), respectively. On multivariate analysis, T stage (P<.001), Gleason score (P<.001), and >50% of initial biopsy positive core (P=.001) were predictive for distant mestastases. No prostate cancer-related deaths were observed in the low-risk group. The 7-year prostate cancer-specific mortality (PCSM) rates, using competing risk analysis for intermediate- and high-risk groups, were 3.3% and 8.1%, respectively (P=.008). On multivariate analysis, Gleason score (P=.004), percentage of biopsy core positivity (P=.003), and T-stage (P=.033) were predictive for PCSM. Actuarial 7-year grade 2 or higher late gastrointestinal and genitourinary toxicities were 4.4% and 21.1%, respectively. Late grade 3 gastrointestinal and genitourinary toxicity was experienced by 7 patients (0.7%) and 22 patients (2.2%), respectively. Of the 427 men with full potency at baseline, 317 men (74%) retained sexual function at time of last follow-up. Conclusions: This study represents the largest cohort of patients treated with high-dose radiation to 86.4 Gy, using IMRT for localized prostate cancer, with the longest follow-up to date. Our findings indicate that this treatment results in excellent clinical outcomes with acceptable toxicity.

  13. Microsoft Word - BLM WAPA Herbicide Use FINAL working20160119.docx

    Office of Environmental Management (EM)

    the Interior Bureau of Land Management And U.S. Department of Energy Western Area Power Administration _________________________________ Environmental Assessment DOI-BLM-AZ-P020-2016-0005-EA DOE/EA-2013 January 25, 2016 HERBICIDE APPLICATION AT THREE WESTERN AREA POWER ADMINISTRATION SUBSTATIONS Lower Sonoran Field Office 21605 North 7 th Avenue Phoenix, Arizona 85027 Western Area Power Administration Desert Southwest Region P.O. Box 6457 Phoenix, Arizona 85005 DOI-BLM-AZ-P020-2016-0005-EA

  14. Nanoparticle toxicity testing

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nanoparticle toxicity testing 1663 Los Alamos science and technology magazine Latest Issue:October 2015 past issues All Issues » submit Nanoparticle toxicity testing Assessing the potential health hazards of nanotechnology March 25, 2013 Robot In the search for more accurate and efficient techniques to evaluate the health hazards of nanoparticles, Los Alamos researchers are developing artificial human tissues and organs to replace animal test subjects. A new approach to toxicity testing under

  15. Modified cellulose synthase gene from Arabidopsis thaliana confers herbicide resistance to plants

    DOE Patents [OSTI]

    Somerville, Chris R. (Portola Valley, CA); Scheible, Wolf (Golm, DE)

    2007-07-10

    Cellulose synthase ("CS"), a key enzyme in the biosynthesis of cellulose in plants is inhibited by herbicides comprising thiazolidinones such as 5-tert-butyl-carbamoyloxy-3-(3-trifluromethyl)phenyl-4-thiazolidinone (TZ), isoxaben and 2,6-dichlorobenzonitrile (DCB). Two mutant genes encoding isoxaben and TZ-resistant cellulose synthase have been isolated from isoxaben and TZ-resistant Arabidopsis thaliana mutants. When compared with the gene coding for isoxaben or TZ-sensitive cellulose synthase, one of the resistant CS genes contains a point mutation, wherein glycine residue 998 is replaced by an aspartic acid. The other resistant mutation is due to a threonine to isoleucine change at amino acid residue 942. The mutant CS gene can be used to impart herbicide resistance to a plant; thereby permitting the utilization of the herbicide as a single application at a concentration which ensures the complete or substantially complete killing of weeds, while leaving the transgenic crop plant essentially undamaged.

  16. Toxic Substances Control Act

    SciTech Connect (OSTI)

    Not Available

    1992-05-15

    This Reference Book contains a current copy of the Toxic Substances Control Act and those regulations that implement the statute and appear to be most relevant to DOE activities. The document is provided to DOE and contractor staff for informational purposes only and should not be interpreted as legal guidance. Questions concerning this Reference Book may be directed to Mark Petts, EH-231 (202/586-2609).

  17. Toxicity of Uranium Adsorbent Materials using the Microtox Toxicity Test

    SciTech Connect (OSTI)

    Park, Jiyeon; Jeters, Robert T.; Gill, Gary A.; Kuo, Li-Jung; Bonheyo, George T.

    2015-10-01

    The Marine Sciences Laboratory at the Pacific Northwest National Laboratory evaluated the toxicity of a diverse range of natural and synthetic materials used to extract uranium from seawater. The uranium adsorbent materials are being developed as part of the U. S. Department of Energy, Office of Nuclear Energy, Fuel Resources Program. The goal of this effort was to identify whether deployment of a farm of these materials into the marine environment would have any toxic effects on marine organisms.

  18. California Environmental Protection Agency Department of Toxic...

    Open Energy Info (EERE)

    Department of Toxic Substances Control Jump to: navigation, search Name: California Environmental Protection Agency Department of Toxic Substances Control Place: Sacramento,...

  19. Toxic Remediation System And Method

    DOE Patents [OSTI]

    Matthews, Stephen M. (Alameda County, CA); Schonberg, Russell G. (Santa Clara County, CA); Fadness, David R. (Santa Clara County, CA)

    1996-07-23

    What is disclosed is a novel toxic waste remediation system designed to provide on-site destruction of a wide variety of hazardous organic volatile hydrocarbons, including but not limited to halogenated and aromatic hydrocarbons in the vapor phase. This invention utilizes a detoxification plenum and radiation treatment which transforms hazardous organic compounds into non-hazardous substances.

  20. Toxicity evaluation and hazard review Cold Smoke

    SciTech Connect (OSTI)

    Archuleta, M.M.; Stocum, W.E.

    1993-12-01

    Cold Smoke is a dense white smoke produced by the reaction of titanium tetrachloride and aqueous ammonia aerosols. Early studies on the toxicity of this nonpyrotechnically generated smoke indicated that the smoke itself is essentially non-toxic (i.e. exhibits to systemic toxicity or organ damage due to exposure) under normal deployment conditions. The purpose of this evaluation was to review and summarize the recent literature data available on the toxicity of Cold Smoke, its chemical constituents, and its starting materials.

  1. Toxic Substances Control Act Uranium Enrichment Federal Facility...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Toxic Substances Control Act Uranium Enrichment Federal Facility Compliance Agreement Toxic Substances Control Act Uranium Enrichment Federal Facility Compliance Agreement Toxic...

  2. Pharmacokinetic drivers of toxicity for basic molecules: Strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor

    SciTech Connect (OSTI)

    Diaz, Dolores; Ford, Kevin A.; Hartley, Dylan P.; Harstad, Eric B.; Cain, Gary R.; Achilles-Poon, Kirsten; Nguyen, Trung; Peng, Jing; Zheng, Zhong; Merchant, Mark; Sutherlin, Daniel P.; Gaudino, John J.; Kaus, Robert; Lewin-Koh, Sock C.; Choo, Edna F.; Liederer, Bianca M.; Dambach, Donna M.

    2013-01-01

    Several toxicities are clearly driven by free drug concentrations in plasma, such as toxicities related to on-target exaggerated pharmacology or off-target pharmacological activity associated with receptors, enzymes or ion channels. However, there are examples in which organ toxicities appear to correlate better with total drug concentrations in the target tissues, rather than with free drug concentrations in plasma. Here we present a case study in which a small molecule Met inhibitor, GEN-203, with significant liver and bone marrow toxicity in preclinical species was modified with the intention of increasing the safety margin. GEN-203 is a lipophilic weak base as demonstrated by its physicochemical and structural properties: high LogD (distribution coefficient) (4.3) and high measured pKa (7.45) due to the basic amine (N-ethyl-3-fluoro-4-aminopiperidine). The physicochemical properties of GEN-203 were hypothesized to drive the high distribution of this compound to tissues as evidenced by a moderately-high volume of distribution (Vd > 3 l/kg) in mouse and subsequent toxicities of the compound. Specifically, the basicity of GEN-203 was decreased through addition of a second fluorine in the 3-position of the aminopiperidine to yield GEN-890 (N-ethyl-3,3-difluoro-4-aminopiperidine), which decreased the volume of distribution of the compound in mouse (Vd = 1.0 l/kg), decreased its tissue drug concentrations and led to decreased toxicity in mice. This strategy suggests that when toxicity is driven by tissue drug concentrations, optimization of the physicochemical parameters that drive tissue distribution can result in decreased drug concentrations in tissues, resulting in lower toxicity and improved safety margins. -- Highlights: ? Lower pKa for a small molecule: reduced tissue drug levels and toxicity. ? New analysis tools to assess electrostatic effects and ionization are presented. ? Chemical and PK drivers of toxicity can be leveraged to improve safety.

  3. Mutation assays involving blood cells that metabolize toxic substances

    DOE Patents [OSTI]

    Crespi, Charles L. (Downers Grove, IL); Thilly, William G. (Winchester, MA)

    1985-01-01

    A line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity) is disclosed. Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. Mutation assays using these cells, and other cells with similar characteristics, are also disclosed.

  4. Mutation assays involving blood cells that metabolize toxic substances

    DOE Patents [OSTI]

    Crespi, Charles L. (Marblehead, MA); Thilly, William G. (Winchester, MA)

    1999-01-01

    The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics.

  5. Mutation assays involving blood cells that metabolize toxic substances

    DOE Patents [OSTI]

    Crespi, C.L.; Thilly, W.G.

    1999-08-10

    The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics. 3 figs.

  6. Enhanced toxic cloud knockdown spray system for decontamination applications

    DOE Patents [OSTI]

    Betty, Rita G. (Rio Rancho, NM); Tucker, Mark D. (Albuquerque, NM); Brockmann, John E. (Albuquerque, NM); Lucero, Daniel A. (Albuquerque, NM); Levin, Bruce L. (Tijeras, NM); Leonard, Jonathan (Albuquerque, NM)

    2011-09-06

    Methods and systems for knockdown and neutralization of toxic clouds of aerosolized chemical or biological warfare (CBW) agents and toxic industrial chemicals using a non-toxic, non-corrosive aqueous decontamination formulation.

  7. Renewable, Non-Toxic and Cost Competitive Solvents and Plasticizers...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Renewable, Non-Toxic and Cost Competitive Solvents and Plasticizers Renewable, Non-Toxic and Cost Competitive Solvents and Plasticizers Breakout Session 1-D: The Pitch Renewable,...

  8. Relationship Between Composition and Toxicity of Engine Emission...

    Broader source: Energy.gov (indexed) [DOE]

    More Documents & Publications Lung Toxicity and Mutagenicity of Emissions From Heavy-Duty Compressed Natural Gas (CNG)-Powered Vehicles Comparative Toxicity of Combined Particle ...

  9. Acute aquatic toxicity of biodiesel fuels

    SciTech Connect (OSTI)

    Wright, B.; Haws, R.; Little, D.; Reese, D.; Peterson, C.; Moeller, G.

    1995-12-31

    This study develops data on the acute aquatic toxicity of selected biodiesel fuels which may become subject to environmental effects test regulations under the US Toxic Substances Control Act (TSCA). The test substances are Rape Methyl Ester (RME), Rape Ethyl Ester (REE), Methyl Soyate (MS), a biodiesel mixture of 20% REE and 80% Diesel, a biodiesel mixture of 50% REE and diesel, and a reference substance of Phillips D-2 Reference Diesel. The test procedure follows the Daphnid Acute Toxicity Test outlined in 40 CFR {section} 797.1300 of the TSCA regulations. Daphnia Magna are exposed to the test substance in a flow-through system consisting of a mixing chamber, a proportional diluter, and duplicate test chambers. Novel system modifications are described that accommodate the testing of oil-based test substances with Daphnia. The acute aquatic toxicity is estimated by an EC50, an effective concentration producing immobility in 50% of the test specimen.

  10. Surviving the toxics in south Louisiana: A minority perspective

    SciTech Connect (OSTI)

    Wright, B.

    1995-12-01

    The Louisiana industrial corridor along the Mississippi River is lined with 136 petro-chemical plants and serves oil refineries. This approximates nearly one plant or refinery for every half mile of the river. The air, ground, and water along this corridor are so full or carcinogens that it has been described as a massive human experiment. Poor blacks live in river towns near the brunt of this discharge. Total mortality rates and cancer mortality rates in counties along the Mississippi River are significantly higher than in the rest of the nation`s counties. Moreover, the areas of greatest toxic discharge. Findings of disproportionately high mortality rates along the Mississippi, especially in communities on the lower river where toxic discharge minority and poor communities along the Mississippi River chemical corridor.

  11. Evaluations in support of regulatory and research decisions by the U. S. Environmental Protection Agency for the control of toxic hazards from hazardous wastes, glyphosate, dalapon, and synthetic fuels

    SciTech Connect (OSTI)

    Scofield, R.

    1984-01-01

    This report includes toxicological and regulatory evaluations performed in support of U.S. EPA regulation of toxic materials and hazardous wastes. The first section of the report describes evaluations which support: (a) the regulation of small-volume generators of hazardous wastes, (b) the regulation of hazardous wastes from pesticide manufacturing, and (c) the disposal of the herbicide, silvex. The second section describes the environmental fate, transport, and effect of glyphosate and dalapon. The third section deals with synthetic fuels, including evaluations of synfuel-product toxicity, uncontrolled air emissions, and particular focus on the toxicity of products from several indirect coal liquefaction processes including methanol synthesis, Fischer-Tropsch, Mobil M-Gasoline, and Lurgi gasification technologies. Three direct coal liquefaction processes were examined for product toxicity and air emissions: Solvent Refined Coal (I and II) and the Exxon Donor Solvent Process. Also described in the third section is an evaluation of environmental and health hazards associated with the use of synthetic fuels from indirect coal liquefaction, direct coal liquefaction, and shale oil. Finally, the fourth section discusses some problems associated with performing, on a contractual basis, scientific and technical evaluations in support of U.S. EPA regulatory and research decisions.

  12. Assessing the toxic effects of ethylene glycol ethers using Quantitative Structure Toxicity Relationship models

    SciTech Connect (OSTI)

    Ruiz, Patricia; Mumtaz, Moiz; Gombar, Vijay

    2011-07-15

    Experimental determination of toxicity profiles consumes a great deal of time, money, and other resources. Consequently, businesses, societies, and regulators strive for reliable alternatives such as Quantitative Structure Toxicity Relationship (QSTR) models to fill gaps in toxicity profiles of compounds of concern to human health. The use of glycol ethers and their health effects have recently attracted the attention of international organizations such as the World Health Organization (WHO). The board members of Concise International Chemical Assessment Documents (CICAD) recently identified inadequate testing as well as gaps in toxicity profiles of ethylene glycol mono-n-alkyl ethers (EGEs). The CICAD board requested the ATSDR Computational Toxicology and Methods Development Laboratory to conduct QSTR assessments of certain specific toxicity endpoints for these chemicals. In order to evaluate the potential health effects of EGEs, CICAD proposed a critical QSTR analysis of the mutagenicity, carcinogenicity, and developmental effects of EGEs and other selected chemicals. We report here results of the application of QSTRs to assess rodent carcinogenicity, mutagenicity, and developmental toxicity of four EGEs: 2-methoxyethanol, 2-ethoxyethanol, 2-propoxyethanol, and 2-butoxyethanol and their metabolites. Neither mutagenicity nor carcinogenicity is indicated for the parent compounds, but these compounds are predicted to be developmental toxicants. The predicted toxicity effects were subjected to reverse QSTR (rQSTR) analysis to identify structural attributes that may be the main drivers of the developmental toxicity potential of these compounds.

  13. Effects of water hardness on the toxicity of manganese to developing brown trout (Salmo trutta)

    SciTech Connect (OSTI)

    Stubblefield, W.A.; Garrison, T.D.; Hockett, J.R.; Brinkman, S.F.; Davies, P.H.; McIntyre, M.W.

    1997-10-01

    Manganese is a common constituent of point and nonpoint discharges from mining and smelting activities. Available data indicate that Mn is acutely toxic at relatively high aqueous concentrations, when compared with trace metals, and its toxicity is affected by water hardness. Little information is available regarding the chronic toxicity of manganese. Early-life-stage (ELS) tests were conducted to determine the toxicity of manganese to brown trout (Salmo trutta) and to evaluate the extent to which water hardness (ranging from 30 to 450 mg/L as CaCO{sub 3}) affects the chronic toxicity of Mn. Water hardness of significantly affected Mn chronic toxicity, with toxicity decreasing with increasing hardness. Decreased survival was the predominant effect noted in the 30-mg/L hardness experiment, while significant effects on growth (as measured by changes in body weight) were observed in both the 150- and 450-mg/L hardness experiments. Twenty-five percent inhibition concentration (IC25) values, based on the combined endpoints (i.e., survival and body weight), were 4.67, 5.59, and 8.68 mg Mn/L (based on measured Mn concentration) at hardness levels of approximately 30, 150, and 450 mg/L as CaCO{sub 3}, respectively.

  14. Hazard index for underground toxic material

    SciTech Connect (OSTI)

    Smith, C.F.; Cohen, J.J.; McKone, T.E.

    1980-06-01

    To adequately define the problem of waste management, quantitative measures of hazard must be used. This study reviews past work in the area of hazard indices and proposes a geotoxicity hazard index for use in characterizing the hazard of toxic material buried underground. Factors included in this index are: an intrinsic toxicity factor, formulated as the volume of water required for dilution to public drinking-water levels; a persistence factor to characterize the longevity of the material, ranging from unity for stable materials to smaller values for shorter-lived materials; an availability factor that relates the transport potential for the particular material to a reference value for its naturally occurring analog; and a correction factor to accommodate the buildup of decay progeny, resulting in increased toxicity.

  15. DOE contractor's meeting on chemical toxicity

    SciTech Connect (OSTI)

    Not Available

    1987-01-01

    The Office of Health and Environmental Research (OHER) is required to determine the potential health and environmental effects associated with energy production and use. To ensure appropriate communication among investigators and scientific disciplines that these research studies represent, OHER has sponsored workshops. This document provides a compilation of activities at the Third Annual DOE/OHER Workshop. This year's workshop was broadened to include all OHER activities identified as within the chemical effects area. The workshop consisted of eight sessions entitled Isolation and Detection of Toxic chemicals; Adduct Formation and Repair; Chemical Toxicity (Posters); Metabolism and Genotoxicity; Inhalation Toxicology; Gene Regulation; Metals Toxicity; and Biological Mechanisms. This document contains abstracts of the information presented by session.

  16. Acute inhalation toxicity of carbonyl sulfide

    SciTech Connect (OSTI)

    Benson, J.M.; Hahn, F.F.; Barr, E.B. [and others

    1995-12-01

    Carbonyl sulfide (COS), a colorless gas, is a side product of industrial procedures sure as coal hydrogenation and gasification. It is structurally related to and is a metabolite of carbon disulfide. COS is metabolized in the body by carbonic anhydrase to hydrogen sulfide (H{sub 2}S), which is thought to be responsible for COS toxicity. No threshold limit value for COS has been established. Results of these studies indicate COS (with an LC{sub 50} of 590 ppm) is slightly less acutely toxic than H{sub 2}S (LC{sub 50} of 440 ppm).

  17. Predictive Factors for Acute and Late Urinary Toxicity After Permanent Prostate Brachytherapy: Long-Term Outcome in 712 Consecutive Patients

    SciTech Connect (OSTI)

    Keyes, Mira Miller, Stacy; Moravan, Veronika; Pickles, Tom; McKenzie, Michael; Pai, Howard; Liu, Mitchell; Kwan, Winkle; Agranovich, Alexander; Spadinger, Ingrid; Lapointe, Vincent; Halperin, Ross; Morris, W. James

    2009-03-15

    Purpose: To describe the frequency of acute and late Radiation Therapy Oncology Group (RTOG) urinary toxicity, associated predictive factors, and resolution of International Prostate Symptom Score (IPSS) in 712 consecutive prostate brachytherapy patients. Methods and Materials: Patients underwent implantation between 1998 and 2003 (median follow-up, 57 months). The IPSS and RTOG toxicity data were prospectively collected. The patient, treatment, and implant factors were examined for an association with urinary toxicity. The time to IPSS resolution was examined using Kaplan-Meier curves, and multivariate modeling of IPSS resolution was done using Cox proportional hazards regression analysis. Logistic regression analysis was used to examine the factors associated with urinary toxicity. Results: The IPSS returned to baseline at a median of 12.6 months. On multivariate analysis, patients with a high baseline IPSS had a quicker resolution of their IPSS. Higher prostate D90 (dose covering 90% of the prostate), maximal postimplant IPSS, and urinary retention slowed the IPSS resolution time. The rate of the actuarial 5-year late urinary (>12 months) RTOG Grade 0, 1, 2, 3, and 4 was 32%, 36%, 24%, 6.2%, and 0.1%, respectively. At 7 years, the prevalence of RTOG Grade 0-1 was 92.5%. Patients with a larger prostate volume, greater number of needles, greater baseline IPSS, and use of hormonal therapy had more acute toxicity. On multivariate analysis, the significant predictors for late greater than or equal to RTOG toxicity 2 were a greater baseline IPSS, maximal postimplant IPSS, presence of acute toxicity, and higher prostate V150 (volume of the prostate covered by 150% of the dose). More recently implanted patients had less acute urinary toxicity and patients given hormonal therapy had less late urinary toxicity (all p < 0.02). Conclusion: Most urinary symptoms resolved within 12 months after prostate brachytherapy, and significant long-term urinary toxicity was very low. Refined patient selection and greater technical experience in prostate brachytherapy were associated with less urinary toxicity.

  18. Toxicity Data to Determine Refrigerant Concentration Limits

    SciTech Connect (OSTI)

    Calm, James M.

    2000-09-30

    This report reviews toxicity data, identifies sources for them, and presents resulting exposure limits for refrigerants for consideration by qualified parties in developing safety guides, standards, codes, and regulations. It outlines a method to calculate an acute toxicity exposure limit (ATEL) and from it a recommended refrigerant concentration limit (RCL) for emergency exposures. The report focuses on acute toxicity with particular attention to lethality, cardiac sensitization, anesthetic and central nervous system effects, and other escape-impairing effects. It addresses R-11, R-12, R-22, R-23, R-113, R-114, R-116, R-123, R-124, R-125, R-134, R-134a, R-E134, R-141b, R-142b, R-143a, R-152a, R-218, R-227ea, R-236fa, R-245ca, R-245fa, R-290, R-500, R-502, R-600a, R-717, and R-744. It summarizes additional data for R-14, R-115, R-170 (ethane), R-C318, R-600 (n-butane), and R-1270 (propylene) to enable calculation of limits for blends incorporating them. The report summarizes the data a nd related safety information, including classifications and flammability data. It also presents a series of tables with proposed ATEL and RCL concentrations-in dimensionless form and the latter also in both metric (SI) and inch-pound (IP) units of measure-for both the cited refrigerants and 66 zerotropic and azeotropic blends. They include common refrigerants, such as R-404A, R-407C, R-410A, and R-507A, as well as others in commercial or developmental status. Appendices provide profiles for the cited single-compound refrigerants and for R-500 and R-502 as well as narrative toxicity summaries for common refrigerants. The report includes an extensive set of references.

  19. Hydrogen and Gaseous Fuel Safety and Toxicity

    SciTech Connect (OSTI)

    Lee C. Cadwallader; J. Sephen Herring

    2007-06-01

    Non-traditional motor fuels are receiving increased attention and use. This paper examines the safety of three alternative gaseous fuels plus gasoline and the advantages and disadvantages of each. The gaseous fuels are hydrogen, methane (natural gas), and propane. Qualitatively, the overall risks of the four fuels should be close. Gasoline is the most toxic. For small leaks, hydrogen has the highest ignition probability and the gaseous fuels have the highest risk of a burning jet or cloud.

  20. Toxic Substances Control Act Uranium Enrichment Federal Facility Compliance

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Agreement | Department of Energy Toxic Substances Control Act Uranium Enrichment Federal Facility Compliance Agreement Toxic Substances Control Act Uranium Enrichment Federal Facility Compliance Agreement Toxic Substances Control Act (TSCA) Uranium Enrichment Federal Facility Compliance Agreement establishes a plan to bring DOE's Uranium Enrichment Plants (and support facilities) located in Portsmouth, Ohio and Paducah, Kentucky and DOE's former Uranium Enrichment Plant (and support

  1. Toxicity of contaminants in lagoons and pannes of the Indiana Dunes National Lakeshore

    SciTech Connect (OSTI)

    Gillespie, R.; Speelman, J. [Indiana Univ.-Purdue Univ., Fort Wayne, IN (United States); Stewart, P.M. [National Biological Service, Porter, IN (United States). Indiana Dunes National Lakeshore

    1995-12-31

    Contaminants in water and sediments of lagoons and pannes were 2--90 times greater at sites adjacent to slag and coal piles than those at reference sites. One site (Lagoon-US5) had sediments with very high concentrations of toxic organics (e.g. naphthalene, phenanthrene, dibenzofuran). Although analyses indicated a gradient of contaminant concentration with distance from their sources, toxicity assays were somewhat equivocal. With the exception of less reproduction in Ceriodaphnia at one lagoon site (US3 = 0.55 of reference), survival of fathead minnows and reproduction in Ceriodaphnia in lagoon and panne waters varied independently of the contaminant concentration. In fact, there was better Ceriodaphnia reproduction in water from two contaminated sites (Lagoon-US5, Panne-WP1) than in water from reference sites. Fathead minnow survival, Ceriodaphnia survival, Ceriodaphnia reproduction, amphipod survival, and amphipod growth varied among sites in toxicity assays with sediments, 100% mortality of fatheads at Lagoon-US5, 100% mortality of Ceriodaphnia at Lagoon-US3, and less survival of fathead minnows at Lagoon-US3 indicate possible toxicity from contaminants in sediments at these sites. Of all organisms and end-points tested, Ceriodaphnia survival seemed to be most closely associated with concentrations of contaminants in lagoon water and sediments. Amphipod survival also varied with contaminants in sediments, however, survival in sediments of contaminated sites ranged only from 0.90--0.93 of reference sites. Although the results are not consistent among organisms, toxicity assays indicate that sediments from the lagoon site with the highest contaminants (Lagoon-US5) and possibly those from another contaminated lagoon site (Lagoon-US3) could be toxic to aquatic organisms. Water and sediments from contaminated panne sites do not appear to be toxic to aquatic test organisms.

  2. Yellow phosphorus process to convert toxic chemicals to non-toxic products

    DOE Patents [OSTI]

    Chang, S.G.

    1994-07-26

    The present invention relates to a process for generating reactive species for destroying toxic chemicals. This process first contacts air or oxygen with aqueous emulsions of molten yellow phosphorus. This contact results in rapid production of abundant reactive species such as O, O[sub 3], PO, PO[sub 2], etc. A gaseous or liquid aqueous solution organic or inorganic chemicals is next contacted by these reactive species to reduce the concentration of toxic chemical and result in a non-toxic product. The final oxidation product of yellow phosphorus is phosphoric acid of a quality which can be recovered for commercial use. A process is developed such that the byproduct, phosphoric acid, is obtained without contamination of toxic species in liquids treated. A gas stream containing ozone without contamination of phosphorus containing species is also obtained in a simple and cost-effective manner. This process is demonstrated to be effective for destroying many types of toxic organic, or inorganic, compounds, including polychlorinated biphenyls (PCB), aromatic chlorides, amines, alcohols, acids, nitro aromatics, aliphatic chlorides, polynuclear aromatic compounds (PAH), dyes, pesticides, sulfides, hydroxyamines, ureas, dithionates and the like. 20 figs.

  3. Yellow phosphorus process to convert toxic chemicals to non-toxic products

    DOE Patents [OSTI]

    Chang, Shih-Ger (El Cerrito, CA)

    1994-01-01

    The present invention relates to a process for generating reactive species for destroying toxic chemicals. This process first contacts air or oxygen with aqueous emulsions of molten yellow phosphorus. This contact results in rapid production of abundant reactive species such as O, O.sub.3, PO, PO.sub.2, etc. A gaseous or liquid aqueous solution organic or inorganic chemicals is next contacted by these reactive species to reduce the concentration of toxic chemical and result in a non-toxic product. The final oxidation product of yellow phosphorus is phosphoric acid of a quality which can be recovered for commercial use. A process is developed such that the byproduct, phosphoric acid, is obtained without contamination of toxic species in liquids treated. A gas stream containing ozone without contamination of phosphorus containing species is also obtained in a simple and cost-effective manner. This process is demonstrated to be effective for destroying many types of toxic organic, or inorganic, compounds, including polychlorinated biphenyls (PCB), aromatic chlorides, amines, alcohols, acids, nitro aromatics, aliphatic chlorides, polynuclear aromatic compounds (PAH), dyes, pesticides, sulfides, hydroxyamines, ureas, dithionates and the like.

  4. Organic ligands reduce copper toxicity in Pseudomonas syringae

    SciTech Connect (OSTI)

    Azenha, M.; Vasconcelos, M.T.; Cabral, J.P.S.

    1995-03-01

    Pseudomonas syringae cells were exposed to 100 {mu}M copper alone, or to previously equilibrated copper sulfate-ligand solutions. Ligand concentrations were determined experimentally as those that reduced the free copper concentration to 5 {mu}M (determined with a Cu{sup 2+}-selective electrode). These values were in agreement with those calculated by computational equilibrium simulation based on published stability constants. Exposure of P. syringae cells to copper sulfate, chloride, or nitrate resulted in similar high mortality, suggesting that copper was responsible for cell death. Acetate, succinate, proline, lysine, cysteine, and EDTA significantly reduced both the amount of copper bound to the cells and cell death, indicating that not only strong chelating agents but also weak and moderate copper ligands can effectively antagonize copper toxicity. However, cysteine and EDTA were considerably more effective than acetate, succinate, proline, and lysine, indicating that copper toxicity is not simply a function of free copper concentration but depends on the nature of the ligand. The results suggested that a significant fraction of copper bound to acetate, succinate, proline, or lysine was displaced to the bacteria or, alternatively, mixed copper-ligand-cell complexes could be formed. On the contrary, none of these phenomena occurred for the copper complexes with cysteine or EDTA.

  5. U.S. Army Toxic and Hazardous

    Office of Legacy Management (LM)

    JUL 2 3 1982 Col. John 0. Spence - U.S. Army Toxic and Hazardous Katerials Agency (DRxTH-AS) Department of the Army Aberdeen Roving Ground, Kd. 21010 .I' r\. Dear Col. Spence: In response to your letter of May 17, 1982. requesting the identification of sites where radiological materials amy have been left or burl& on U.S. Anny Installations, I am enclosing littlngs of military installatlans that may have been involved with the Manhattan Engineer District/Atomic Energy Camnlssion (KED/AEC)

  6. Method and apparatus for diagnosis of lead toxicity

    DOE Patents [OSTI]

    Rosen, John F. (Riverside, CT); Slatkin, Daniel N. (Bayside, NY); Wielopolski, Lucian (Shirley, NY)

    1989-01-01

    Improved methods and apparatus for in vivo measurement of the skeletal lead burden of a patient and for diagnosis of lead toxicity are disclosed. The apparatus comprises an x-ray tube emitting soft low energy x-rays from a silver anode, a polarizer for polarizing the emitted x-rays, and a detector for detecting photons fluoresced from atoms in the patient's tibia upon irradiation by the polarized x-rays. The fluoresced photons are spectrally analyzed to determine their energy distribution. Peaks indicating the presence of lead are identified if the patient has relatively high bone lead content. The data may be compared to data recorded with respect to a similar test performed on patients having also had the conventional EDTA chelation tests performed thereon in order to correlate the test results with respect to a particular patient to the conventionally accepted EDTA chelation test.

  7. Relationship Between Composition and Toxicity of Engine Emission Samples |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Emission Samples Relationship Between Composition and Toxicity of Engine Emission Samples 2003 DEER Conference Presentation: Lovelace Respiratory Research Institute PDF icon 2003_deer_mauderly.pdf More Documents & Publications Lung Toxicity and Mutagenicity of Emissions From Heavy-Duty Compressed Natural Gas (CNG)-Powered Vehicles Comparative Toxicity of Combined Particle and Semi-Volatile Organic Fractioins of Gasoline and Diesel Emissions Relationship Between

  8. Renewable, Non-Toxic and Cost Competitive Solvents and Plasticizers |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Renewable, Non-Toxic and Cost Competitive Solvents and Plasticizers Renewable, Non-Toxic and Cost Competitive Solvents and Plasticizers Breakout Session 1-D: The Pitch Renewable, Non-Toxic and Cost Competitive Solvents and Plasticizers Len Rand, Chief Executive Officer, Chairman, xF Technologies PDF icon rand_bioenergy_2015.pdf More Documents & Publications Vehicle Technologies Office Merit Review 2015: Development of Industrially Viable Battery Electrode Coatings

  9. Comparative Toxicity of Combined Particle and Semi-Volatile Organic

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fractioins of Gasoline and Diesel Emissions | Department of Energy Toxicity of Combined Particle and Semi-Volatile Organic Fractioins of Gasoline and Diesel Emissions Comparative Toxicity of Combined Particle and Semi-Volatile Organic Fractioins of Gasoline and Diesel Emissions 2002 DEER Conference Presentation: Lovelace Respiratory Research Institute PDF icon 2002_deer_mauderly.pdf More Documents & Publications Relationship Between Composition and Toxicity of Engine Emission Samples

  10. Toxic Substances Control Act Uranium Enrichment Federal Facilities...

    Office of Environmental Management (EM)

    of Pesticides and Toxic Substances U.S. Environmental Protection Agency William H. Young Assistant Secretary for Nuclear Energy U.S. Department of Energy Leo P. Duffy...

  11. Comparative Toxicity of Combined Particle and Semi-Volatile Organic...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Components Responsible for the Health Effects of Inhaled Engine Emissions Lung Toxicity and Mutagenicity of Emissions From Heavy-Duty Compressed Natural Gas (CNG)-Powered Vehicles

  12. Early Proctoscopy is a Surrogate Endpoint of Late Rectal Toxicity...

    Office of Scientific and Technical Information (OSTI)

    Prostate Cancer Treated With Radiotherapy Citation Details In-Document Search Title: Early Proctoscopy is a Surrogate Endpoint of Late Rectal Toxicity in Prostate Cancer Treated ...

  13. Toxic chemical considerations for tank farm releases

    SciTech Connect (OSTI)

    Van Keuren, J.C.; Davis, J.S., Westinghouse Hanford

    1996-08-01

    This topical report contains technical information used to determine the accident consequences of releases of toxic chemical and gases for the Tank Farm Final Safety Analysis report (FSAR).It does not provide results for specific accident scenarios but does provide information for use in those calculations including chemicals to be considered, chemical concentrations, chemical limits and a method of summing the fractional contributions of each chemical. Tank farm composites evaluated were liquids and solids for double shell tanks, single shell tanks, all solids,all liquids, headspace gases, and 241-C-106 solids. Emergency response planning guidelines (ERPGs) were used as the limits.Where ERPGs were not available for the chemicals of interest, surrogate ERPGs were developed. Revision 2 includes updated sample data, an executive summary, and some editorial revisions.

  14. Evaluation of the effects of coal fly ash amendments on the toxicity of a contaminated marine sediment

    SciTech Connect (OSTI)

    Burgess, R.M.; Perron, M.M.; Friedman, C.L.; Suuberg, E.M.; Pennell, K.G.; Cantwell, M.G.; Pelletier, M.C.; Ho, K.T.; Serbst, J.R.; Ryba, S.A.

    2009-01-15

    Approaches for cleaning up contaminated sediments range from dredging to in situ treatment. In this study, we discuss the effects of amending reference and contaminated sediments with coal fly ash to reduce the bioavailability and toxicity of a field sediment contaminated with polycyclic aromatic hydrocarbons (PAHs). Six fly ashes and a coconut charcoal were evaluated in 7-d whole sediment toxicity tests with a marine amphipod (Ampelisca abdita) and mysid (Americamysis bahia). Fly ashes with high carbon content and the coconut charcoal showed proficiency at reducing toxicity. Some of the fly ashes demonstrated toxicity in the reference treatments. It is suspected that some of this toxicity is related to the presence of ammonia associated with fly ashes as a result of postoxidation treatment to reduce nitrous oxide emissions. Relatively simple methods exist to remove ammonia from fly ash before use, and fly ashes with low ammonia content are available. Fly ashes were also shown to effectively reduce overlying water concentrations of several PAHs. No evidence was seen of the release of the metals cadmium, copper, nickel, or lead from the fly ashes. A preliminary 28-d polychaete bioaccumulation study with one of the high-carbon fly ashes and a reference sediment was also performed. Although preliminary, no evidence was seen of adverse effects to worm growth or lipid content or of accumulation of PAHs or mercury from exposure to the fly ash. These data show fly ashes with high carbon content could represent viable remedial materials for reducing the bioavailability of organic contaminants in sediments.

  15. Court decision dropping toxic substance rules stands

    SciTech Connect (OSTI)

    Bryant, C.R.

    1993-06-01

    In a somewhat surprising move, the U.S. Department of Labor has decided not to appeal a court decision essentially dropping regulations established by the Occupational Safety and Health Administration (OSHA) for about 400 hazardous substances. The decision leaves unregulated or subject to reduced standards substances that range from carbon monoxide to perchloroethylene. The Labor Department had until March 22, 1993, to appeal the court decision. On July 8, 1992, the U.S. Court of Appeals for the 11th Circuit overturned OSHA's final Air Contaminants Standard, which was promulgated in 1989. The standard established permissible exposure limits (PELs) for 428 toxic substances. In AFL-CIO vs. OSHA, the Court ruled that OSHA failed to make a separate scientific case for evaluating health risks of each chemical. Because of the decision not to appeal, PELs for more than half of the substances regulated by OSHA now are removed from the books or revert to the voluntary industry standards adopted by OSHA in 1970 and in force prior to the 1989 final rule.

  16. Acute aquatic toxicity and biodegradation potential of biodiesel fuels

    SciTech Connect (OSTI)

    Haws, R.A.; Zhang, X.; Marshall, E.A.; Reese, D.L.; Peterson, C.L.; Moeller, G.

    1995-12-31

    Recent studies on the biodegradation potential and aquatic toxicity of biodiesel fuels are reviewed. Biodegradation data were obtained using the shaker flask method observing the appearance of CO{sub 2} and by observing the disappearance of test substance with gas chromatography. Additional BOD{sub 5} and COD data were obtained. The results indicate the ready biodegradability of biodiesel fuels as well as the enhanced co-metabolic biodegradation of biodiesel and petroleum diesel fuel mixtures. The study examined reference diesel, neat soy oil, neat rape oil, and the methyl and ethyl esters of these vegetable oils as well as various fuel blends. Acute toxicity tests on biodiesel fuels and blends were performed using Oncorhynchus mykiss (Rainbow Trout) in a static non-renewal system and in a proportional dilution flow replacement system. The study is intended to develop data on the acute aquatic toxicity of biodiesel fuels and blends under US EPA Good Laboratory Practice Standards. The test procedure is designed from the guidelines outlined in Methods for Measuring the Acute Toxicity of Effluents and Receiving Waters to Freshwater and Marine Organisms and the Fish Acute Aquatic Toxicity Test guideline used to develop aquatic toxicity data for substances subject to environmental effects test regulations under TSCA. The acute aquatic toxicity is estimated by an LC50, a lethal concentration effecting mortality in 50% of the test population.

  17. Physicochemical properties and toxicities of hydrophobicpiperidinium and pyrrolidinium ionic liquids

    SciTech Connect (OSTI)

    Salminen, Justin; Papaiconomou, Nicolas; Kumar, R. Anand; Lee,Jong-Min; Kerr, John; Newman, John; Prausnitz, John M.

    2007-06-25

    Some properties are reported for hydrophobic ionic liquids (IL) containing 1-methyl-1-propyl pyrrolidinium [MPPyrro]{sup +}, 1-methyl-1-butyl pyrrolidinium [MBPyrro]{sup +}, 1-methyl-1-propyl piperidinium [MPPip]{sup +}, 1-methyl-1-butyl piperidinium [MBPip]{sup +}, 1-methyl-1-octylpyrrolidinium [MOPyrro]{sup +} and 1-methyl-1-octylpiperidinium [MOPip]{sup +} cations. These liquids provide new alternatives to pyridinium and imidazolium ILs. High thermal stability of an ionic liquid increases safety in applications like rechargeable lithium-ion batteries and other electrochemical devices. Thermal properties, ionic conductivities, viscosities, and mutual solubilities with water are reported. In addition, toxicities of selected ionic liquids have been measured using a human cancer cell-line. The ILs studied here are sparingly soluble in water but hygroscopic. We show some structure-property relationships that may help to design green solvents for specific applications. While ionic liquids are claimed to be environmentally-benign solvents, as yet few data have been published to support these claims.

  18. Oxidative stress-induced autophagy: Role in pulmonary toxicity

    SciTech Connect (OSTI)

    Malaviya, Rama; Laskin, Jeffrey D.; Laskin, Debra L.

    2014-03-01

    Autophagy is an evolutionarily conserved catabolic process important in regulating the turnover of essential proteins and in elimination of damaged organelles and protein aggregates. Autophagy is observed in the lung in response to oxidative stress generated as a consequence of exposure to environmental toxicants. Whether autophagy plays role in promoting cell survival or cytotoxicity is unclear. In this article recent findings on oxidative stress-induced autophagy in the lung are reviewed; potential mechanisms initiating autophagy are also discussed. A better understanding of autophagy and its role in pulmonary toxicity may lead to the development of new strategies to treat lung injury associated with oxidative stress. - Highlights: Exposure to pulmonary toxicants is associated with oxidative stress. Oxidative stress is known to induce autophagy. Autophagy is upregulated in the lung following exposure to pulmonary toxicants. Autophagy may be protective or pathogenic.

  19. Toxic Chemical Release Inventory reporting ``Qs & As``. Environmental Guidance

    SciTech Connect (OSTI)

    Not Available

    1994-03-01

    This document offers guidance on toxic chemical release inventory reporting, pursuant to Section 313 of the Emergency Planning and Community Right-to-Know Act (EPCRA) at DOE sites.

  20. Multiple Species of Bacteria Convert Elemental Mercury to Toxic...

    Office of Science (SC) Website

    Researchers are studying how bacteria transform mercury into a toxic form in the environment that can accumulate in the food web, posing a threat to wildlife and people. The ...

  1. Nano/bio treatment of polychlorinated biphenyls with evaluation of comparative toxicity

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Le, Thao Thanh; Francis, Arokiasamy J.; Nguyen, Hoang Khanh; Jeon, Jong -Rok; Chang, Yoon -Seok

    2015-02-03

    The persistence of polychlorinated biphenyl (PCB) Aroclor 1248 in soils and sediments is a major concern because of its toxicity and presence at high concentrations. In this study, we developed an integrated remediation system for PCBs using chemical catalysis and biodegradation. The dechlorination of Aroclor 1248 was achieved by treatment with bimetallic nanoparticles Pd/nFe under anoxic conditions. Among the 32 PCB congeners of Aroclor 1248 examined, our process dechlorinated 99%, 92%, 84%, and 28% of tri-, tetra-, penta-, and hexachlorinated biphenyls, respectively. The resulting biphenyl was biodegraded rapidly by Burkholderia xenovorans LB400. Benzoic acid was detected as an intermediate duringmore » the biodegradation process. The toxicity of the residual PCBs after nano-bio treatment was evaluated in terms of toxic equivalent values which decreased from 33.8 × 10-5 μg g-1 to 9.5 × 10-5 μg g-1. The residual PCBs also had low cytotoxicity toward Escherichia coli as demonstrated by lower reactive oxygen species levels, lower glutathione peroxidase activity, and a reduced number of dead bacteria.« less

  2. Proteomic analysis of rat cerebral cortex following subchronic acrolein toxicity

    SciTech Connect (OSTI)

    Rashedinia, Marzieh; Lari, Parisa; Abnous, Khalil; Hosseinzadeh, Hossein

    2013-10-01

    Acrolein, a member of reactive ?,?-unsaturated aldehydes, is a major environmental pollutant. Acrolein is also produced endogenously as a toxic by-product of lipid peroxidation. Because of high reactivity, acrolein may mediate oxidative damages to cells and tissues. It has been shown to be involved in a wide variety of pathological states including pulmonary, atherosclerosis and neurodegenerative diseases. In this study we employed proteomics approach to investigate the effects of subchronic oral exposures to 3 mg/kg of acrolein on protein expression profile in the brain of rats. Moreover effects of acrolein on malondialdehyde (MDA) levels and reduced glutathione (GSH) content were investigated. Our results revealed that treatment with acrolein changed levels of several proteins in diverse physiological process including energy metabolism, cell communication and transport, response to stimulus and metabolic process. Interestingly, several differentially over-expressed proteins, including ?-synuclein, enolase and calcineurin, are known to be associated with human neurodegenerative diseases. Changes in the levels of some proteins were confirmed by Western blot. Moreover, acrolein increases the level of MDA, as a lipid peroxidation biomarker and decreased GSH concentrations, as a non-enzyme antioxidant in the brain of acrolein treated rats. These findings suggested that acrolein induces the oxidative stress and lipid peroxidation in the brain, and so that may contribute to the pathophysiology of neurological disorders. - Highlights: Acrolein intoxication increased lipid peroxidation and deplete GSH in rat brain. Effect of acrolein on protein levels of cerebral cortex was analyzed by 2DE-PAGE. Levels of a number of proteins with different biological functions were increased.

  3. Survey of toxicity and carcinogenity of mineral deposits

    SciTech Connect (OSTI)

    Furst, A.; Harding-Barlow, I.

    1981-11-03

    The toxicities and biogeochemical cycles of arsenic, cadmium, chromium, lead and nickel are reviewed in some detail, and other trace elements briefly mentioned. These heavy metals are used as a framework within which the problem of low-level radioactive waste disposal can be compared. (ACR)

  4. Advanced regenerative thermal oxidation (RTO) technology for air toxics control - selected case histories

    SciTech Connect (OSTI)

    Seiwert, J.J. Jr.

    1997-12-31

    Advanced design regenerative thermal oxidation (RTO) systems have been developed and are in commercial scale use for control of process emissions containing air toxics (HAPs) and VOCs. High operating temperatures coupled with high thermal energy recovery efficiencies inherent with RTO technology provide for high destruction efficiencies while minimizing formation of objectionable combustion byproducts. These results are achieved with low system operating costs. This paper covers development of advanced design commercial RTO systems for control of air emissions from several important commercial processes: total reduced sulfur (TRS) and other HAPs/VOC emissions from pulp mill processes. Chlorinated organics and other HAPs/VOC emissions from pharmaceutical manufacturing operations. The data presented represent the first commercial scale application of RTO technology to abate emissions from these processes. Particular design features required for each specific process, in order to provide reliable, safe and effective systems, are reviewed. Emissions abatement performance, as well as operational data, are presented for the systems.

  5. SU-E-J-149: Establishing the Relationship Between Pre-Treatment Lung Ventilation, Dose, and Toxicity Outcome

    SciTech Connect (OSTI)

    Mistry, N; D'Souza, W; Sornsen de Koste, J; Senan, S

    2014-06-01

    Purpose: Recently, there has been an interest in incorporating functional information in treatment planning especially in thoracic tumors. The rationale is that healthy lung regions need to be spared from radiation if possible to help achieve better control on toxicity. However, it is still unclear whether high functioning regions need to be spared or have more capacity to deal with the excessive radiation as compared to the compromised regions of the lung. Our goal with this work is to establish the tools by which we can establish a relationship between pre-treatment lung function, dose, and radiographic outcomes of lung toxicity. Methods: Treatment planning was performed using a single phase of a 4DCT scan, and follow-up anatomical CT scans were performed every 3 months for most patients. In this study, we developed the pipeline of tools needed to analyze such a large dataset, while trying to establish a relationship between function, dose, and outcome. Pre-treatment lung function was evaluated using a recently published technique that evaluates Fractional Regional Ventilation (FRV). All images including the FRV map and the individual follow-up anatomical CT images were all spatially matched to the planning CT using a diffusion based Demons image registration algorithm. Change in HU value was used as a metric to capture the effects of lung toxicity. To validate the findings, a radiologist evaluated the follow-up anatomical CT images and scored lung toxicity. Results: Initial experience in 1 patient shows a relationship between the pre-treatment lung function, dose and toxicity outcome. The results are also correlated to the findings by the radiologist who was blinded to the analysis or dose. Conclusion: The pipeline we have established to study this enables future studies in large retrospective studies. However, the tools are dependent on the fidelity of 4DCT reconstruction for accurate evaluation of regional ventilation. Patent Pending for the technique presented in this work to evaluate FRV incorporating mass correction.

  6. Reliability of Quantitative Ultrasonic Assessment of Normal-Tissue Toxicity in Breast Cancer Radiotherapy

    SciTech Connect (OSTI)

    Yoshida, Emi J.; Chen Hao; Torres, Mylin; Andic, Fundagul; Liu Haoyang; Chen Zhengjia; Sun, Xiaoyan; Curran, Walter J.; Liu Tian

    2012-02-01

    Purpose: We have recently reported that ultrasound imaging, together with ultrasound tissue characterization (UTC), can provide quantitative assessment of radiation-induced normal-tissue toxicity. This study's purpose is to evaluate the reliability of our quantitative ultrasound technology in assessing acute and late normal-tissue toxicity in breast cancer radiotherapy. Method and Materials: Our ultrasound technique analyzes radiofrequency echo signals and provides quantitative measures of dermal, hypodermal, and glandular tissue toxicities. To facilitate easy clinical implementation, we further refined this technique by developing a semiautomatic ultrasound-based toxicity assessment tool (UBTAT). Seventy-two ultrasound studies of 26 patients (720 images) were analyzed. Images of 8 patients were evaluated for acute toxicity (<6 months postradiotherapy) and those of 18 patients were evaluated for late toxicity ({>=}6 months postradiotherapy). All patients were treated according to a standard radiotherapy protocol. To assess intraobserver reliability, one observer analyzed 720 images in UBTAT and then repeated the analysis 3 months later. To assess interobserver reliability, three observers (two radiation oncologists and one ultrasound expert) each analyzed 720 images in UBTAT. An intraclass correlation coefficient (ICC) was used to evaluate intra- and interobserver reliability. Ultrasound assessment and clinical evaluation were also compared. Results: Intraobserver ICC was 0.89 for dermal toxicity, 0.74 for hypodermal toxicity, and 0.96 for glandular tissue toxicity. Interobserver ICC was 0.78 for dermal toxicity, 0.74 for hypodermal toxicity, and 0.94 for glandular tissue toxicity. Statistical analysis found significant changes in dermal (p < 0.0001), hypodermal (p = 0.0027), and glandular tissue (p < 0.0001) assessments in the acute toxicity group. Ultrasound measurements correlated with clinical Radiation Therapy Oncology Group (RTOG) toxicity scores of patients in the late toxicity group. Patients with RTOG Grade 1 or 2 had greater ultrasound-assessed toxicity percentage changes than patients with RTOG Grade 0. Conclusion: Early and late radiation-induced effects on normal tissue can be reliably assessed using quantitative ultrasound.

  7. Saltone 2QCY15 TCLP toxicity and UTS results

    SciTech Connect (OSTI)

    Miller, D. H.

    2015-08-01

    A Saltstone Disposal Facility (SDF) waste form was prepared in the Savannah River National Laboratory (SRNL) from a Tank 50H sample and Z-Area premix material for the second quarter of calendar year 2015 (2QCY15). After a 28 day cure, a sample of the SDF waste form was collected, and shipped to a certified laboratory for Toxic Characteristic and Universal Treatment Standards (UTS) analysis. The metals analysis is performed using the Toxic Characteristic Leaching Procedure (TCLP)1. The 2QCY15 saltstone sample results meet South Carolina Hazardous Waste Management Regulations (SCHWMR) R.61-79.261.24 and R.61-79.268.48(a) requirements for a nonhazardous waste form with respect to RCRA metals and underlying hazardous constituents (UHC).

  8. Saltstone 1QCY15 TCLP Toxicity and UTS Results

    SciTech Connect (OSTI)

    Miller, D.

    2015-07-29

    A Saltstone Disposal Facility (SDF) waste form was prepared in the Savannah River National Laboratory (SRNL) from a Tank 50H sample and Z-Area premix material for the first quarter of calendar year 2015 (1QCY15). After a 28 day cure, a sample of the SDF waste form was collected, and shipped to a certified laboratory for Toxic Characteristic and Universal Treatment Standards (UTS) analysis. The metals analysis is performed using the Toxic Characteristic Leaching Procedure (TCLP). The 1QCY15 saltstone sample results meet South Carolina Hazardous Waste Management Regulations (SCHWMR) R.61-79.261.24 and R.61-79.268.48(a) requirements for a nonhazardous waste form with respect to RCRA metals and underlying hazardous constituents (UHC).

  9. Saltstone 2QCY15 TCLP toxicity and UTS results

    SciTech Connect (OSTI)

    Miller, D. H.

    2015-07-31

    A Saltstone Disposal Facility (SDF) waste form was prepared in the Savannah River National Laboratory (SRNL) from a Tank 50H sample and Z-Area premix material for the second quarter of calendar year 2015 (2QCY15). After a 28 day cure, a sample of the SDF waste form was collected, and shipped to a certified laboratory for Toxic Characteristic and Universal Treatment Standards (UTS) analysis. The metals analysis is performed using the Toxic Characteristic Leaching Procedure (TCLP). The 2QCY15 saltstone sample results meet South Carolina Hazardous Waste Management Regulations (SCHWMR) R.61-79.261.24 and R.61-79.268.48(a) requirements for a nonhazardous waste form with respect to RCRA metals and underlying hazardous constituents (UHC).

  10. Saltstone 3QCY15 TCLP Toxicity and UTS Results

    SciTech Connect (OSTI)

    Miller, D.

    2015-12-09

    A Saltstone Disposal Facility (SDF) waste form was prepared in the Savannah River National Laboratory (SRNL) from a Tank 50H sample and Z-Area premix material for the third quarter of calendar year 2015 (3QCY15). After a 28 day cure, a sample of the SDF waste form was collected, and shipped to a certified laboratory for Toxic Characteristic and Universal Treatment Standards (UTS) analysis. The metals analysis is performed using the Toxic Characteristic Leaching Procedure (TCLP).1 The 3QCY15 saltstone sample results meet South Carolina Hazardous Waste Management Regulations (SCHWMR) R.61-79.261.24 and R.61-79.268.48(a) requirements for a nonhazardous waste form with respect to RCRA metals and underlying hazardous constituents (UHC).

  11. Reactive formulations for a neutralization of toxic industrial chemicals

    DOE Patents [OSTI]

    Tucker, Mark D.; Betty, Rita G.

    2006-10-24

    Decontamination formulations for neutralization of toxic industrial chemicals, and methods of making and using same. The formulations are effective for neutralizing malathion, hydrogen cyanide, sodium cyanide, butyl isocyanate, carbon disulfide, phosgene gas, capsaicin in commercial pepper spray, chlorine gas, anhydrous ammonia gas; and may be effective at neutralizing hydrogen sulfide, sulfur dioxide, formaldehyde, ethylene oxide, methyl bromide, boron trichloride, fluorine, tetraethyl pyrophosphate, phosphorous trichloride, arsine, and tungsten hexafluoride.

  12. Low toxicity method of inhibiting sickling of sickle erythrocytes

    DOE Patents [OSTI]

    Packer, Lester; Bymun, Edwin N.

    1977-01-01

    A low toxicity method of inhibiting sickling of sickle erythrocytes which comprises intermixing the erythrocytes with an effective anti-sickling amount of a water-soluble imidoester of the formula RC(=NH)OR' wherein R is an alkyl group of 1 - 8 carbon atoms, particularly 1 - 4 carbon atoms, and R' is an alkyl group of 1 - 4 carbon atoms, specifically methyl or ethyl acetimidate.

  13. Interaction Between Toxic Metals and Complex Biofilm/Mineral/Solution

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Interfaces highlights title by Alexis S. Templeton, Thomas P. Trainor, and Gordon E. Brown, Jr., Stanford University Sorption reactions on particle surfaces can dramatically affect the speciation, cycling and bioavailability of essential micronutrients (i.e. PO43-, Cu, Zn etc.) and toxic metals and metalloids (i.e. Pb, Hg, Se, As) in soils and aquatic environments. Considerable attention has been focused on understanding metal sorption reactions at a molecular/mechanistic level and the

  14. Relationship Between Composition and Toxicity of Engine Emissions |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Emissions Relationship Between Composition and Toxicity of Engine Emissions 2004 Diesel Engine Emissions Reduction (DEER) Conference Presentation: Lovelace Respiratory Research Instiitute PDF icon 2004_deer_mcdonald.pdf More Documents & Publications The Effect of Changes in Diesel Exhaust Composition and After-Treatment Technology on Lung Inflammation and Resistance to Viral Infection Components Responsible for the Health Effects of Inhaled Engine Emissions

  15. Comparative developmental toxicity of environmentally relevant oxygenated PAHs

    SciTech Connect (OSTI)

    Knecht, Andrea L.; Goodale, Britton C.; Truong, Lisa; Simonich, Michael T.; Swanson, Annika J.; Matzke, Melissa M.; Anderson, Kim A.; Waters, Katrina M.; Tanguay, Robert L.

    2013-09-01

    Oxygenated polycyclic aromatic hydrocarbons (OPAHs) are byproducts of combustion and photo-oxidation of parent PAHs. OPAHs are widely present in the environment and pose an unknown hazard to human health. The developing zebrafish was used to evaluate a structurally diverse set of 38 OPAHs for malformation induction, gene expression changes and mitochondrial function. Zebrafish embryos were exposed from 6 to 120 h post fertilization (hpf) to a dilution series of 38 different OPAHs and evaluated for 22 developmental endpoints. AHR activation was determined via CYP1A immunohistochemistry. Phenanthrenequinone (9,10-PHEQ), 1,9-benz-10-anthrone (BEZO), xanthone (XAN), benz(a)anthracene-7,12-dione (7,12-B[a]AQ), and 9,10-anthraquinone (9,10-ANTQ) were evaluated for transcriptional responses at 48 hpf, prior to the onset of malformations. qRT-PCR was conducted for a number of oxidative stress genes, including the glutathione transferase(gst), glutathione peroxidase(gpx), and superoxide dismutase(sod) families. Bioenergetics was assayed to measure in vivo oxidative stress and mitochondrial function in 26 hpf embryos exposed to OPAHs. Hierarchical clustering of the structure-activity outcomes indicated that the most toxic of the OPAHs contained adjacent diones on 6-carbon moieties or terminal, para-diones on multi-ring structures. 5-carbon moieties with adjacent diones were among the least toxic OPAHs while the toxicity of multi-ring structures with more centralized para-diones varied considerably. 9,10-PHEQ, BEZO, 7,12-B[a]AQ, and XAN exposures increased expression of several oxidative stress related genes and decreased oxygen consumption rate (OCR), a measurement of mitochondrial respiration. Comprehensive in vivo characterization of 38 structurally diverse OPAHs indicated differential AHR dependency and a prominent role for oxidative stress in the toxicity mechanisms. - Highlights: OPAHs are byproducts of combustion present in the environment. OPAHs pose a largely unknown hazard to human health. We assayed the developmental toxicology of 39 different OPAHs in zebrafish. The most toxic OPAHs contained adjacent diones or terminal, para-diones. AHR dependency varied among OPAHs, and oxidative stress influenced their toxicology.

  16. Mechanisms of carbon nanotube-induced toxicity: Focus on oxidative stress

    SciTech Connect (OSTI)

    Shvedova, Anna A.; Pietroiusti, Antonio; Fadeel, Bengt; Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA ; Kagan, Valerian E.

    2012-06-01

    Nanotechnologies are emerging as highly promising technologies in many sectors in the society. However, the increasing use of engineered nanomaterials also raises concerns about inadvertent exposure to these materials and the potential for adverse effects on human health and the environment. Despite several years of intensive investigations, a common paradigm for the understanding of nanoparticle-induced toxicity remains to be firmly established. Here, the so-called oxidative stress paradigm is scrutinized. Does oxidative stress represent a secondary event resulting inevitably from disruption of biochemical processes and the demise of the cell, or a specific, non-random event that plays a role in the induction of cellular damage e.g. apoptosis? The answer to this question will have important ramifications for the development of strategies for mitigation of adverse effects of nanoparticles. Recent examples of global lipidomics studies of nanoparticle-induced tissue damage are discussed along with proteomics and transcriptomics approaches to achieve a comprehensive understanding of the complex and interrelated molecular changes in cells and tissues exposed to nanoparticles. We also discuss instances of non-oxidative stress-mediated cellular damage resulting from direct physical interference of nanomaterials with cellular structures. -- Highlights: ? CNT induced non-random oxidative stress associated with apoptosis. ? Non-oxidative mechanisms for cellular toxicity of carbon nanotubes. ? Biodegradation of CNT by cells of innate immune system. ? Omics-based biomarkers of CNT exposures.

  17. Evaluation of Chemical Warfare Agent Percutaneous Vapor Toxicity: Derivation of Toxicity Guidelines for Assessing Chemical Protective Ensembles.

    SciTech Connect (OSTI)

    Watson, A.P.

    2003-07-24

    Percutaneous vapor toxicity guidelines are provided for assessment and selection of chemical protective ensembles (CPEs) to be used by civilian and military first responders operating in a chemical warfare agent vapor environment. The agents evaluated include the G-series and VX nerve agents, the vesicant sulfur mustard (agent HD) and, to a lesser extent, the vesicant Lewisite (agent L). The focus of this evaluation is percutaneous vapor permeation of CPEs and the resulting skin absorption, as inhalation and ocular exposures are assumed to be largely eliminated through use of SCBA and full-face protective masks. Selection of appropriately protective CPE designs and materials incorporates a variety of test parameters to ensure operability, practicality, and adequacy. One aspect of adequacy assessment should be based on systems tests, which focus on effective protection of the most vulnerable body regions (e.g., the groin area), as identified in this analysis. The toxicity range of agent-specific cumulative exposures (Cts) derived in this analysis can be used as decision guidelines for CPE acceptance, in conjunction with weighting consideration towards more susceptible body regions. This toxicity range is bounded by the percutaneous vapor estimated minimal effect (EME{sub pv}) Ct (as the lower end) and the 1% population threshold effect (ECt{sub 01}) estimate. Assumptions of exposure duration used in CPE certification should consider that each agent-specific percutaneous vapor cumulative exposure Ct for a given endpoint is a constant for exposure durations between 30 min and 2 hours.

  18. Air toxics evaluation of ABB Combustion Engineering Low-Emission Boiler Systems

    SciTech Connect (OSTI)

    Wesnor, J.D.

    1993-10-26

    The specific goals of the program are to identify air toxic compounds that might be emmitted from the new boiler with its various Air Pollution Control device for APCD alternatives in levels of regulatory concern. For the compounds thought to be of concern, potential air toxic control methodologies will be suggested and a Test Protocol will be written to be used in the Proof of Concept and full scale tests. The following task was defined: Define Replations and Standards; Identify Air Toxic Pollutants of Interest to Interest to Utility Boilers; Assesment of Air Toxic By-Products; State of the Art Assessment of Toxic By-Product Control Technologies; and Test Protocol Definition.

  19. ROLE OF TOXICITY ASSESSMENT AND MONITORING IN MANAGING THE RECOVERY OF A WASTEWATER RECEIVING STREAM

    SciTech Connect (OSTI)

    Greeley Jr, Mark Stephen; Kszos, Lynn A; Stewart, Arthur J; Smith, John G

    2011-01-01

    We evaluate the roles of a long-term comprehensive toxicity assessment and monitoring program in management and for ecological recovery of a freshwater receiving stream impacted by industrial discharges and legacy contamination. National Pollution Discharge Elimination Permit (NPDES)-driven whole effluent toxicity (WET) tests using Ceriodaphnia and fathead minnows were conducted for more than twenty years to characterize wastewaters at the US National Nuclear Security Agency s Y-12 National Security Complex in Oak Ridge, Tennessee. Ambient toxicity tests also were conducted to assess water samples from EFPC, the stream receiving the wastewater discharges. The ambient tests were conducted as part of an extensive biological monitoring program that included routine surveys of fish, invertebrate and periphyton communities. WET testing, associated toxicant identification evaluations (TIEs), and ambient toxicity monitoring were instrumental in identifying toxicants and their sources at the Y-12 Complex, guiding modifications to wastewater treatment procedures, and assessing the success of various pollution-abatement actions. Through time, as requirements changed and water quality improved, the toxicity monitoring program became more focused. Ambient testing with Ceriodaphnia and fathead minnow larvae also was supplemented with less-standardized but more-sensitive alternative laboratory and in situ bioassays. The Y-12 Complex biological monitoring experience demonstrates the significant roles effluent and ambient toxicity testing can have in controlling and managing toxic discharges to receiving waters. It also emphasizes the value of supplementing WET and standardized ambient toxicity tests with alternative laboratory and in situ toxicity tests tailored to address specific problems.

  20. Mobile Source Air Toxics Rule (released in AEO2008)

    Reports and Publications (EIA)

    2008-01-01

    On February 9, 2007, the Environmental Protection Agency (EPA) released its MSAT2 rule, which will establish controls on gasoline, passenger vehicles, and portable fuel containers. The controls are designed to reduce emissions of benzene and other hazardous air pollutants. Benzene is a known carcinogen, and the EPA estimates that mobile sources produced more than 70% of all benzene emissions in 1999. Other mobile source air toxics, including 1,3-butadiene, formaldehyde, acetaldehyde, acrolein, and naphthalene, also are thought to increase cancer rates or contribute to other serious health problems.

  1. SU-E-T-206: Improving Radiotherapy Toxicity Based On Artificial Neural Network (ANN) for Head and Neck Cancer Patients

    SciTech Connect (OSTI)

    Cho, Daniel D; Wernicke, A Gabriella; Nori, Dattatreyudu; Chao, KSC; Parashar, Bhupesh; Chang, Jenghwa [Weill Cornell Medical College, NY, NY (United States)

    2014-06-01

    Purpose/Objective(s): The aim of this study is to build the estimator of toxicity using artificial neural network (ANN) for head and neck cancer patients Materials/Methods: An ANN can combine variables into a predictive model during training and considered all possible correlations of variables. We constructed an ANN based on the data from 73 patients with advanced H and N cancer treated with external beam radiotherapy and/or chemotherapy at our institution. For the toxicity estimator we defined input data including age, sex, site, stage, pathology, status of chemo, technique of external beam radiation therapy (EBRT), length of treatment, dose of EBRT, status of post operation, length of follow-up, the status of local recurrences and distant metastasis. These data were digitized based on the significance and fed to the ANN as input nodes. We used 20 hidden nodes (for the 13 input nodes) to take care of the correlations of input nodes. For training ANN, we divided data into three subsets such as training set, validation set and test set. Finally, we built the estimator for the toxicity from ANN output. Results: We used 13 input variables including the status of local recurrences and distant metastasis and 20 hidden nodes for correlations. 59 patients for training set, 7 patients for validation set and 7 patients for test set and fed the inputs to Matlab neural network fitting tool. We trained the data within 15% of errors of outcome. In the end we have the toxicity estimation with 74% of accuracy. Conclusion: We proved in principle that ANN can be a very useful tool for predicting the RT outcomes for high risk H and N patients. Currently we are improving the results using cross validation.

  2. Dosimetric and Late Radiation Toxicity Comparison Between Iodine-125 Brachytherapy and Stereotactic Radiation Therapy for Juxtapapillary Choroidal Melanoma

    SciTech Connect (OSTI)

    Krema, Hatem

    2013-07-01

    Purpose: To compare the dose distributions and late radiation toxicities for {sup 125}I brachytherapy (IBT) and stereotactic radiation therapy (SRT) in the treatment of juxtapapillary choroidal melanoma. Methods: Ninety-four consecutive patients with juxtapapillary melanoma were reviewed: 30 have been treated with IBT and 64 with SRT. Iodine-125 brachytherapy cases were modeled with plaque simulator software for dosimetric analysis. The SRT dosimetric data were obtained from the Radionics XKnife RT3 software. Mean doses at predetermined intraocular points were calculated. Kaplan-Meier estimates determined the actuarial rates of late toxicities, and the logrank test compared the estimates. Results: The median follow-up was 46 months in both cohorts. The 2 cohorts were balanced with respect to pretreatment clinical and tumor characteristics. Comparisons of radiation toxicity rates between the IBT and SRT cohorts yielded actuarial rates at 50 months for cataracts of 62% and 75% (P=.1), for neovascular glaucoma 8% and 47% (P=.002), for radiation retinopathy 59% and 89% (P=.0001), and for radiation papillopathy 39% and 74% (P=.003), respectively. Dosimetric comparisons between the IBT and SRT cohorts yielded mean doses of 12.8 and 14.1 Gy (P=.56) for the lens center, 17.6 and 19.7 Gy (P=.44) for the lens posterior pole, 13.9 and 10.8 Gy (P=.30) for the ciliary body, 61.9 and 69.7 Gy (P=.03) for optic disc center, and 48.9 and 60.1 Gy (P<.0001) for retina at 5-mm distance from tumor margin, respectively. Conclusions: Late radiation-induced toxicities were greater with SRT, which is secondary to the high-dose exposure inherent to the technique as compared with IBT. When technically feasible, IBT is preferred to treat juxtapapillary choroidal melanoma.

  3. Microbial stabilization and mass reduction of wastes containing radionuclides and toxic metals

    DOE Patents [OSTI]

    Francis, A.J.; Dodge, C.J.; Gillow, J.B.

    1991-09-10

    A process is provided to treat wastes containing radionuclides and toxic metals with Clostridium sp. BFGl to release a large fraction of the waste solids into solution and convert the radionuclides and toxic metals to a more concentrated and stable form with concurrent volume and mass reduction. The radionuclides and toxic metals being in a more stable form are available for recovery, recycling and disposal. 18 figures.

  4. Lung Toxicity and Mutagenicity of Emissions From Heavy-Duty Compressed

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Natural Gas (CNG)-Powered Vehicles | Department of Energy Lung Toxicity and Mutagenicity of Emissions From Heavy-Duty Compressed Natural Gas (CNG)-Powered Vehicles Lung Toxicity and Mutagenicity of Emissions From Heavy-Duty Compressed Natural Gas (CNG)-Powered Vehicles 2005 Diesel Engine Emissions Reduction (DEER) Conference Presentations and Posters PDF icon 2005_deer_mauderly.pdf More Documents & Publications Relationship Between Composition and Toxicity of Engine Emission Samples

  5. Early Proctoscopy is a Surrogate Endpoint of Late Rectal Toxicity in

    Office of Scientific and Technical Information (OSTI)

    Prostate Cancer Treated With Radiotherapy (Journal Article) | SciTech Connect Early Proctoscopy is a Surrogate Endpoint of Late Rectal Toxicity in Prostate Cancer Treated With Radiotherapy Citation Details In-Document Search Title: Early Proctoscopy is a Surrogate Endpoint of Late Rectal Toxicity in Prostate Cancer Treated With Radiotherapy Purpose: To predict the grade and incidence of late clinical rectal toxicity through short-term (1 year) mucosal alterations. Methods and Materials:

  6. Microbial stabilization and mass reduction of wastes containing radionuclides and toxic metals

    DOE Patents [OSTI]

    Francis, Arokiasamy J. (Middle Island, NY); Dodge, Cleveland J. (Wading River, NY); Gillow, Jeffrey B. (Valley Cottage, NY)

    1991-01-01

    A process is provided to treat wastes containing radionuclides and toxic metals with Clostridium sp. BFGl to release a large fraction of the waste solids into solutin and convert the radionuclides and toxic metals to a more concentrated and stable form with concurrent volume and mass reduction. The radionuclides and toxic metals being in a more stable form are available for recovery, recycling and disposal.

  7. Summary of EPA Final Rules for Air Toxic Standards for Industrial,

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Commercial, and Institutional (ICI) Boilers and Process Heaters, February 2013 | Department of Energy Summary of EPA Final Rules for Air Toxic Standards for Industrial, Commercial, and Institutional (ICI) Boilers and Process Heaters, February 2013 Summary of EPA Final Rules for Air Toxic Standards for Industrial, Commercial, and Institutional (ICI) Boilers and Process Heaters, February 2013 This summary of EPA Final Rules for Air Toxic Standards for Industrial, Commercial, and Institutional

  8. Pentose fermentation of normally toxic lignocellulose prehydrolysate with strain of Pichia stipitis yeast using air

    DOE Patents [OSTI]

    Keller, Jr., Fred A. (Lakewood, CO); Nguyen, Quang A. (Golden, CO)

    2002-01-01

    Strains of the yeast Pichia stipitis NPw9 (ATCC PTA-3717) useful for the production of ethanol using oxygen for growth while fermenting normally toxic lignocellulosic prehydrolysates.

  9. Summary of EPA Final Rules for Air Toxic Standards for Industrial...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Summary of EPA Final Rules for Air Toxic Standards for Industrial, Commercial, and Institutional (ICI) Boilers and Process Heaters, February 2013 Summary of EPA Final Rules for Air ...

  10. On-Line Microbial Whole Effluent Toxicity Monitoring for Industrial Wastewater

    SciTech Connect (OSTI)

    Mathews, S; Hoppes, W; Mascetti, M; Campbell, C G

    2002-09-17

    In this study a respirometer is tested for its ability to act as an early upset warning device and whole effluent toxicity monitor for industrial discharge. Industrial discharge water quality is commonly evaluated by comparing measured chemical concentrations to target values or regulatory limits established by governmental agencies. Unless the regulatory values are based upon empirical data, the actual effect of the discharge on aquatic systems is unknown. At the same time assessing the environmental toxicology of wastewater discharges is complicated by synergistic relationships among chemical constituents producing greater total toxicity. For example, metals may be more toxic in waters with low total hardness or more soluble at lower pH. An alternative approach that we are investigating is whole effluent toxicity testing. This study investigates the measurement of whole effluent toxicity through an on-line respirometer that measures toxicity to microorganisms comprising activated sludge. In this approach the oxygen uptake rate is monitored and used as an indicator of microbial activity or health. This study investigates the use of an online whole effluent toxicity testing system to provide early upset warning and the consistency of measured response to low pH. Repeated exposure of the microorganisms to low pH results in reduced sensitivity of the microbial population. We investigate whether this reduction in sensitivity results from physiological acclimation or changes in species composition. We identify promising applications, where, with proper calibration, respirometry based toxicity monitoring appear to be well suited for relative comparisons of whole effluent toxicity.

  11. Microcurrent therapeutic technique for treatment of radiation toxicity

    DOE Patents [OSTI]

    Lennox, Arlene (Elburn, IL); Funder, Sandra (Crown Point, IL)

    2000-01-01

    The present technique provides a method of remediating the toxicities associated with radiation therapy. A conductive gel is applied to the affected bodily area. A sinusoidally pulsed biphasic DC current is then applied to the affected bodily area using at least one electrode. The electrode is manipulated using active tactile manipulation by for a predetermined time and the frequency of the sinusoidally pulsed biphasic DC current is decreased during the course of the treatment. The method also includes applying a spiked pulsed biphasic DC current to the affected bodily area using at least one electrode. This electrode is also manipulated using active tactile manipulation by for a predetermined time and the frequency of the spiked pulsed biphasic DC current is also decreased during the course of the treatment.

  12. Air toxic emissions from the combustion of coal: Identifying and quantifying hazardous air pollutants from US coals

    SciTech Connect (OSTI)

    Szpunar, C.B.

    1992-09-01

    This report addresses the key air toxic emissions likely to emanate from continued and expanded use of domestic coal. It identifies and quantifies those trace elements specified in the US 1990 Clean Air Act Amendments, by tabulating selected characterization data on various source coals by region, state, and rank. On the basis of measurements by various researchers, this report also identifies those organic compounds likely to be derived from the coal combustion process (although their formation is highly dependent on specific boiler configurations and operating conditions).

  13. A novel nanoparticle-based disposable electrochemical immunosensor for diagnosis of exposure to toxic organophosphorus agents

    SciTech Connect (OSTI)

    Lu, Donglai; Wang, Jun; Wang, Limin; Du, Dan; Timchalk, Charles; Barry, Richard C.; Lin, Yuehe

    2011-11-15

    We present a novel disposable electrochemical immunosensor for highly selective and sensitive detection of organophosphorylated butyrylcholinesterase (OP-BChE), a specific biomarker for exposure to toxic organophosphorus agents. In our new approach, the zirconia nanoparticles (ZrO-2) were employed to selectively capture the OP moiety of OP-BChE adducts, and followed by quantum dot (QD)-tagged anti-BChE antibodies for amplified quantification. The captured CdSe-QD tags can be sensitively detected by stripping voltammetry using in situ bismuth-plating method. The OP agent, diisopropylfluorophosphate (DFP), was selected to prepare OP-BChE adducts in various matrices. The formation of OP-BChE adducts in plasma sample was confirmed using mass spectroscopy. The developed electrochemical immunosensor demonstrates a highly linear voltammetric response over the range of 0.1 to 30 nM OP-BChE. Moreover, the immunosensor has been successfully applied for the detection of OP-BChE adducts in the plasma samples. This novel nanoparticle-based electrochemical immunosensor thus provides an alternative way for designing simple, fast, sensitive, and cost-effective sensing platform for on-site screening/evaluating exposure to a variety of OP agents.

  14. Process safety management for highly hazardous chemicals

    SciTech Connect (OSTI)

    1996-02-01

    Purpose of this document is to assist US DOE contractors who work with threshold quantities of highly hazardous chemicals (HHCs), flammable liquids or gases, or explosives in successfully implementing the requirements of OSHA Rule for Process Safety Management of Highly Hazardous Chemicals (29 CFR 1910.119). Purpose of this rule is to prevent releases of HHCs that have the potential to cause catastrophic fires, explosions, or toxic exposures.

  15. Results of Toxicity Studies Conducted on Outfall X-08 and Its Contributing Waste Streams, November 1999 - June 2000

    SciTech Connect (OSTI)

    Specht, W.L.

    2000-06-28

    This interim report summarizes the results of toxicity tests, Toxicity Identification Evaluations, and chemical analyses that have been conducted on SRS's NPDES Outfall X-08 and its contributing waste streams between November 1999 and June 2000.

  16. Mechanism of imidazolium ionic liquids toxicity in Saccharomyces cerevisiae and rational engineering of a tolerant, xylose-fermenting strain

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Dickinson, Quinn; Bottoms, Scott; Hinchman, Li; McIlwain, Sean; Li, Sheena; Myers, Chad L.; Boone, Charles; Coon, Joshua J.; Hebert, Alexander; Sato, Trey K.; et al

    2016-01-20

    In this study, imidazolium ionic liquids (IILs) underpin promising technologies that generate fermentable sugars from lignocellulose for future biorefineries. However, residual IILs are toxic to fermentative microbes such as Saccharomyces cerevisiae, making IIL-tolerance a key property for strain engineering. To enable rational engineering, we used chemical genomic profiling to understand the effects of IILs on S. cerevisiae. As a result, we found that IILs likely target mitochondria as their chemical genomic profiles closely resembled that of the mitochondrial membrane disrupting agent valinomycin. Further, several deletions of genes encoding mitochondrial proteins exhibited increased sensitivity to IIL. High-throughput chemical proteomics confirmed effectsmore » of IILs on mitochondrial protein levels. IILs induced abnormal mitochondrial morphology, as well as altered polarization of mitochondrial membrane potential similar to valinomycin. Deletion of the putative serine/threonine kinase PTK2 thought to activate the plasma-membrane proton efflux pump Pma1p conferred a significant IIL-fitness advantage. Conversely, overexpression of PMA1 conferred sensitivity to IILs, suggesting that hydrogen ion efflux may be coupled to influx of the toxic imidazolium cation. PTK2 deletion conferred resistance to multiple IILs, including [EMIM]Cl, [BMIM]Cl, and [EMIM]Ac. An engineered, xylose-converting ptk2Δ S. cerevisiae (Y133-IIL) strain consumed glucose and xylose faster and produced more ethanol in the presence of 1 % [BMIM]Cl than the wild-type PTK2 strain. We propose a model of IIL toxicity and resistance. In conclusion, this work demonstrates the utility of chemical genomics-guided biodesign for development of superior microbial biocatalysts for the ever-changing landscape of fermentation inhibitors.« less

  17. TOXIC SUBSTANCES FROM COAL COMBUSTION-A COMPREHENSIVE ASSESSMENT

    SciTech Connect (OSTI)

    C.L. Senior; F. Huggins; G.P. Huffman; N. Shah; N. Yap; J.O.L. Wendt; W. Seames; M.R. Ames; A.F. Sarofim; S. Swenson; J.S. Lighty; A. Kolker; R. Finkelman; C.A. Palmer; S.J. Mroczkowski; J.J. Helble; R. Mamani-Paco; R. Sterling; G. Dunham; S. Miller

    2001-06-30

    The Clean Air Act Amendments of 1990 identify a number of hazardous air pollutants (HAPs) as candidates for regulation. Should regulations be imposed on HAP emissions from coal-fired power plants, a sound understanding of the fundamental principles controlling the formation and partitioning of toxic species during coal combustion will be needed. With support from the National Energy Technology Laboratory (NETL), the Electric Power Research Institute, and VTT (Finland), Physical Sciences Inc. (PSI) has teamed with researchers from USGS, MIT, the University of Arizona (UA), the University of Kentucky (UK), the University of Connecticut (UC), the University of Utah (UU) and the University of North Dakota Energy and Environmental Research Center (EERC) to develop a broadly applicable emissions model useful to regulators and utility planners. The new Toxics Partitioning Engineering Model (ToPEM) will be applicable to all combustion conditions including new fuels and coal blends, low-NOx combustion systems, and new power generation plants. Development of ToPEM will be based on PSI's existing Engineering Model for Ash Formation (EMAF). The work discussed in this report covers the Phase II program. Five coals were studied (three in Phase I and two new ones in Phase II). In this work UK has used XAFS and Moessbauer spectroscopies to characterize elements in project coals. For coals, the principal use was to supply direct information about certain hazardous and other key elements (iron) to complement the more complete indirect investigation of elemental modes of occurrence being carried out by colleagues at USGS. Iterative selective leaching using ammonium acetate, HCl, HF, and HNO3, used in conjunction with mineral identification/quantification, and microanalysis of individual mineral grains, has allowed USGS to delineate modes of occurrence for 44 elements. The Phase II coals show rank-dependent systematic differences in trace-element modes of occurrence. The work at UU focused on the behavior of trace metals in the combustion zone by studying vaporization from single coal particles. The coals were burned at 1700 K under a series of fuel-rich and oxygen-rich conditions. The data collected in this study will be applied to a model that accounts for the full equilibrium between carbon monoxide and carbon dioxide. The model also considers many other reactions taking place in the combustion zone, and involves the diffusion of gases into the particle and combustion products away from the particle. A comprehensive study has been conducted at UA to investigate the post-combustion partitioning of trace elements during large-scale combustion of pulverized coal combustion. For many coals, there are three distinct particle regions developed by three separate mechanisms: (1) a submicron fume, (2) a micron-sized fragmentation region, and (3) a bulk (>3 {micro}m) fly ash region. The controlling partitioning mechanisms for trace elements may be different in each of the three particle regions. A substantial majority of semi-volatile trace elements (e.g., As, Se, Sb, Cd, Zn, Pb) volatilize during combustion. The most common partitioning mechanism for semi-volatile elements is reaction with active fly ash surface sites. Experiments conducted under this program at UC focused on measuring mercury oxidation under cooling rates representative of the convective section of a coal-fired boiler to determine the extent of homogeneous mercury oxidation under these conditions. In fixed bed studies at EERC, five different test series were planned to evaluate the effects of temperature, mercury concentration, mercury species, stoichiometric ratio of combustion air, and ash source. Ash samples generated at UA and collected from full-scale power plants were evaluated. Extensive work was carried out at UK during this program to develop new methods for identification of mercury species in fly ash and sorbents. We demonstrated the usefulness of XAFS spectroscopy for the speciation of mercury captured on low-temperature sorbents from combustion flue gases and dev

  18. Acute toxicity of selected metals and phenols on RTG-2 and CHSE-214 fish cell lines

    SciTech Connect (OSTI)

    Castano, A. |; Vega, M.M.; Tarazona, J.V.

    1995-08-01

    In vitro toxicity tests with fish cell lines appear as an alternative to single species bioassays and have been used successfully in different applications, both for single chemicals and for environmental samples, including Toxicity Identification Evaluation procedures. Different fish cell lines, such as BF-2, RTG-2, FHM and R1 have been employed in these toxicological studies. The aim of the present study was to compare the sensitivity of two salmonid fish cell lines, RTG-2 and CHSE-214, in evaluating toxicity of seven compounds (three metals and four phenolic chemicals), by measuring three endpoints: cellular mass, cell viability and intracellular ATP content of the cells. 22 refs., 3 figs., 1 tab.

  19. Analysis of the toxicity in Rocky Flats Plant surface water through a correlation between the whole effluent toxicity test and the Microtox assay

    SciTech Connect (OSTI)

    Ford, S.M.; Wolaver, H.A.; Figueroa, L.A.

    1992-07-01

    Results were correlated from the Microtox assay and the whole effluent acute toxicity test for effluents from the (1) wastewater treatment plant (WWTP) and (2) terminal ponds located at the Rocky Flats Plant. Literature reviews indicate that Photobacterium phosphoreum (Microtox assay) may be used as screening test for the reaction of Ceriodaphnia dubia and Pimephales promelas to toxins present in effluents. This study indicates that the Microtox is less sensitive to toxins present in the WWTP effluent than other test organisms (Ceriodaphnia dubia and Pimephales promelas). Toxicity appears to be from unionized ammonia. Ten months of data reveal that the surface water effluents which leave Rocky Flats boundaries are non-toxic when judged by all three test organisms.

  20. Analysis of the toxicity in Rocky Flats Plant surface water through a correlation between the whole effluent toxicity test and the Microtox assay

    SciTech Connect (OSTI)

    Ford, S.M.; Wolaver, H.A. ); Figueroa, L.A. )

    1992-01-01

    Results were correlated from the Microtox assay and the whole effluent acute toxicity test for effluents from the (1) wastewater treatment plant (WWTP) and (2) terminal ponds located at the Rocky Flats Plant. Literature reviews indicate that Photobacterium phosphoreum (Microtox assay) may be used as screening test for the reaction of Ceriodaphnia dubia and Pimephales promelas to toxins present in effluents. This study indicates that the Microtox is less sensitive to toxins present in the WWTP effluent than other test organisms (Ceriodaphnia dubia and Pimephales promelas). Toxicity appears to be from unionized ammonia. Ten months of data reveal that the surface water effluents which leave Rocky Flats boundaries are non-toxic when judged by all three test organisms.

  1. Application of powder metallurgy techniques for the development of non-toxic ammunition. Final CRADA report

    SciTech Connect (OSTI)

    Lowden, R.; Kelly, R.

    1997-05-30

    The purpose of the Cooperative Research and Development Agreement (CRADA) between Martin Marietta Energy Systems, Inc., and Delta Frangible Ammunition (DFA), was to identify and evaluate composite materials for the development of small arms ammunition. Currently available small arms ammunition utilizes lead as the major component of the projectile. The introduction of lead into the environment by these projectiles when they are expended is a rapidly increasing environmental problem. At certain levels, lead is a toxic metal to the environment and a continual health and safety concern for firearm users as well as those who must conduct lead recovery operations from the environment. DFA is a leading supplier of high-density mixtures, which will be used to replace lead-based ammunition in specific applications. Current non-lead ammunition has several limitations that prevent it from replacing lead-based ammunition in many applications (such as applications that require ballistics, weapon recoil, and weapon function identical to that of lead-based ammunition). The purpose of the CRADA was to perform the research and development to identify cost-effective materials to be used in small arms ammunition that eventually will be used in commercially viable, environmentally conscious, non-lead, frangible and/or non-frangible, ammunition.

  2. Hematologic Toxicity in RTOG 0418: A Phase 2 Study of Postoperative IMRT for Gynecologic Cancer

    SciTech Connect (OSTI)

    Klopp, Ann H.; Moughan, Jennifer; Portelance, Lorraine; Miller, Brigitte E.; Salehpour, Mohammad R.; Hildebrandt, Evangeline; Nuanjing, Jenny; D'Souza, David; Souhami, Luis; Small, William; Gaur, Rakesh; Jhingran, Anuja

    2013-05-01

    Purpose: Intensity modulated radiation therapy (IMRT), compared with conventional 4-field treatment, can reduce the volume of bone marrow irradiated. Pelvic bone marrow sparing has produced a clinically significant reduction in hematologic toxicity (HT). This analysis investigated HT in Radiation Therapy Oncology Group (RTOG) 0418, a prospective study to test the feasibility of delivering postoperative IMRT for cervical and endometrial cancer in a multiinstitutional setting. Methods and Materials: Patients in the RTOG 0418 study were treated with postoperative IMRT to 50.4 Gy to the pelvic lymphatics and vagina. Endometrial cancer patients received IMRT alone, whereas patients with cervical cancer received IMRT and weekly cisplatin (40 mg/m{sup 2}). Pelvic bone marrow was defined within the treatment field by using a computed tomography density-based autocontouring algorithm. The volume of bone marrow receiving 10, 20, 30, and 40 Gy and the median dose to bone marrow were correlated with HT, graded by Common Terminology Criteria for Adverse Events, version 3.0, criteria. Results: Eighty-three patients were eligible for analysis (43 with endometrial cancer and 40 with cervical cancer). Patients with cervical cancer treated with weekly cisplatin and pelvic IMRT had grades 1-5 HT (23%, 33%, 25%, 0%, and 0% of patients, respectively). Among patients with cervical cancer, 83% received 5 or more cycles of cisplatin, and 90% received at least 4 cycles of cisplatin. The median percentage volume of bone marrow receiving 10, 20, 30, and 40 Gy in all 83 patients, respectively, was 96%, 84%, 61%, and 37%. Among cervical cancer patients with a V40 >37%, 75% had grade 2 or higher HT compared with 40% of patients with a V40 less than or equal to 37% (P =.025). Cervical cancer patients with a median bone marrow dose of >34.2 Gy also had higher rates of grade ?2 HT than did those with a dose of ?34.2 Gy (74% vs 43%, P=.049). Conclusions: Pelvic IMRT with weekly cisplatin is associated with low rates of HT and high rates of weekly cisplatin use. The volume of bone marrow receiving 40 Gy and the median dose to bone marrow correlated with higher rates of grade ?2 toxicity among patients receiving weekly cisplatin (cervical cancer patients). Evaluation and limitation of the volume of bone marrow treated with pelvic IMRT is warranted in patients receiving concurrent chemotherapy.

  3. WAC 173-460 - Controls for New Sources of Toxic Air Pollutants...

    Open Energy Info (EERE)

    73-460 - Controls for New Sources of Toxic Air Pollutants Jump to: navigation, search OpenEI Reference LibraryAdd to library Legal Document- RegulationRegulation: WAC 173-460 -...

  4. Toxic Substances Control Act Uranium Enrichment Federal Facilities Compliance Agreement, February 20, 1992

    Office of Environmental Management (EM)

    Thomas L. McCall, Jr. http://www.em.doe.gov/ffaa/ortsca.html 4/25/2001 Toxic Substances Control Act Uranium Enrichment Federal Facilities Compliance Agree.. Page 12 of 26 Deputy Assistant Administrator for Federal Facilities Enforcement Office of Enforcement U.S. Environmental Protection Agency Michael F. Wood, Director Compliance Division Office of Compliance Monitoring Office of Pesticides and Toxic Substances U.S. Environmental Protection Agency William H. Young Assistant Secretary for

  5. A Review of Toxicity and Use and Handling Considerations for Guanidine, Guanidine Hydrochloride, and Urea.

    SciTech Connect (OSTI)

    Ertell, Katherine GB

    2006-03-27

    This is a technical report prepared for Oregon Sustainable Energy, LLC, under Agreement 06-19 with PNNL's Office of Small Business Programs. The request was to perform a review of the toxicity and safe handling of guanidine. The request was later amended to add urea. This report summarizes the toxicity data available in the scientific literature and provides an interpretation of the results and recommendations for handling these compounds.

  6. Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal

    SciTech Connect (OSTI)

    Tsirulnikov, Kirill; Abuladze, Natalia; Bragin, Anatol; Brain Research Institute, University of California at Los Angeles, CA 90095 ; Faull, Kym; Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, CA 90095; Pasarow Mass Spectrometry Laboratory, University of California at Los Angeles, CA 90095 ; Cascio, Duilio; Damoiseaux, Robert; Schibler, Matthew J.; Pushkin, Alexander

    2012-09-15

    4-Hydroxy-2-nonenal (4HNE) and acrolein (ACR) are highly reactive neurotoxic products of lipid peroxidation that are implicated in the pathogenesis and progression of Alzheimer's and Parkinson's diseases. Conjugation with glutathione (GSH) initiates the 4HNE and ACR detoxification pathway, which generates the mercapturates of 4HNE and ACR that can be excreted. Prior work has shown that the efficiency of the GSH-dependent renal detoxification of haloalkene derived mercapturates is significantly decreased upon their deacetylation because of rapid transformation of the deacetylated products into toxic compounds mediated by ?-lyase. The enzymes of the GSH-conjugation pathway and ?-lyases are expressed in the brain, and we hypothesized that a similar toxicity mechanism may be initiated in the brain by the deacetylation of 4HNE- and ACR-mercapturate. The present study was performed to identify an enzyme(s) involved in 4HNE- and ACR-mercapturate deacetylation, characterize the brain expression of this enzyme and determine whether its inhibition decreases 4HNE and 4HNE-mercapturate neurotoxicity. We demonstrated that of two candidate deacetylases, aminoacylases 1 (AA1) and 3 (AA3), only AA3 efficiently deacetylates both 4HNE- and ACR-mercapturate. AA3 was further localized to neurons and blood vessels. Using a small molecule screen we generated high-affinity AA3 inhibitors. Two of them completely protected rat brain cortex neurons expressing AA3 from the toxicity of 4HNE-mercapturate. 4HNE-cysteine (4HNE-Cys) was also neurotoxic and its toxicity was mostly prevented by a ?-lyase inhibitor, aminooxyacetate. The results suggest that the AA3 mediated deacetylation of 4HNE-mercapturate may be involved in the neurotoxicity of 4HNE.

  7. Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model

    SciTech Connect (OSTI)

    deLorimier, Elaine; Coonrod, Leslie A.; Copperman, Jeremy; Taber, Alex; Reister, Emily E.; Sharma, Kush; Todd, Peter K.; Guenza, Marina G.; Berglund, J. Andrew

    2014-10-10

    In this study, CUG repeat expansions in the 3' UTR of dystrophia myotonica protein kinase (DMPK) cause myotonic dystrophy type 1 (DM1). As RNA, these repeats elicit toxicity by sequestering splicing proteins, such as MBNL1, into proteinRNA aggregates. Structural studies demonstrate that CUG repeats can form A-form helices, suggesting that repeat secondary structure could be important in pathogenicity. To evaluate this hypothesis, we utilized structure-stabilizing RNA modifications pseudouridine (?) and 2'-O-methylation to determine if stabilization of CUG helical conformations affected toxicity. CUG repeats modified with ? or 2'-O-methyl groups exhibited enhanced structural stability and reduced affinity for MBNL1. Molecular dynamics and X-ray crystallography suggest a potential water-bridging mechanism for ?-mediated CUG repeat stabilization. ? modification of CUG repeats rescued mis-splicing in a DM1 cell model and prevented CUG repeat toxicity in zebrafish embryos. This study indicates that the structure of toxic RNAs has a significant role in controlling the onset of neuromuscular diseases.

  8. Modifications to toxic CUG RNAs induce structural stability, rescue mis-splicing in a myotonic dystrophy cell model and reduce toxicity in a myotonic dystrophy zebrafish model

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    deLorimier, Elaine; Coonrod, Leslie A.; Copperman, Jeremy; Taber, Alex; Reister, Emily E.; Sharma, Kush; Todd, Peter K.; Guenza, Marina G.; Berglund, J. Andrew

    2014-10-10

    In this study, CUG repeat expansions in the 3' UTR of dystrophia myotonica protein kinase (DMPK) cause myotonic dystrophy type 1 (DM1). As RNA, these repeats elicit toxicity by sequestering splicing proteins, such as MBNL1, into protein–RNA aggregates. Structural studies demonstrate that CUG repeats can form A-form helices, suggesting that repeat secondary structure could be important in pathogenicity. To evaluate this hypothesis, we utilized structure-stabilizing RNA modifications pseudouridine (Ψ) and 2'-O-methylation to determine if stabilization of CUG helical conformations affected toxicity. CUG repeats modified with Ψ or 2'-O-methyl groups exhibited enhanced structural stability and reduced affinity for MBNL1. Molecular dynamicsmore » and X-ray crystallography suggest a potential water-bridging mechanism for Ψ-mediated CUG repeat stabilization. Ψ modification of CUG repeats rescued mis-splicing in a DM1 cell model and prevented CUG repeat toxicity in zebrafish embryos. This study indicates that the structure of toxic RNAs has a significant role in controlling the onset of neuromuscular diseases.« less

  9. The underlying toxicological mechanism of chemical mixtures: A case study on mixture toxicity of cyanogenic toxicants and aldehydes to Photobacterium phosphoreum

    SciTech Connect (OSTI)

    Tian, Dayong; Lin, Zhifen; Zhou, Xianghong; Yin, Daqiang

    2013-10-15

    Intracellular chemical reaction of chemical mixtures is one of the main reasons that cause synergistic or antagonistic effects. However, it still remains unclear what the influencing factors on the intracellular chemical reaction are, and how they influence on the toxicological mechanism of chemical mixtures. To reveal this underlying toxicological mechanism of chemical mixtures, a case study on mixture toxicity of cyanogenic toxicants and aldehydes to Photobacterium phosphoreum was employed, and both their joint effects and mixture toxicity were observed. Then series of two-step linear regressions were performed to describe the relationships between joint effects, the expected additive toxicities and descriptors of individual chemicals (including concentrations, binding affinity to receptors, octanol/water partition coefficients). Based on the quantitative relationships, the underlying joint toxicological mechanisms were revealed. The result shows that, for mixtures with their joint effects resulting from intracellular chemical reaction, their underlying toxicological mechanism depends on not only their interaction with target proteins, but also their transmembrane actions and their concentrations. In addition, two generic points of toxicological mechanism were proposed including the influencing factors on intracellular chemical reaction and the difference of the toxicological mechanism between single reactive chemicals and their mixtures. This study provided an insight into the understanding of the underlying toxicological mechanism for chemical mixtures with intracellular chemical reaction. - Highlights: Joint effects of nitriles and aldehydes at non-equitoxic ratios were determined. A novel descriptor, ligandreceptor interaction energy (E{sub binding}), was employed. Quantitative relationships for mixtures were developed based on a novel descriptor. The underlying toxic mechanism was revealed based on quantitative relationships. Two generic points of toxicological mechanism were elucidated.

  10. 2008 Toxic Chemical Release Inventory 2008 Toxic Chemical Release Inventory Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect (OSTI)

    Ecology and Air Quality Group

    2009-10-01

    For reporting year 2008, Los Alamos National Laboratory (LANL) submitted a Form R report for lead as required under the Emergency Planning and Community Right-to- Know Act (EPCRA) Section 313. No other EPCRA Section 313 chemicals were used in 2008 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2008, as well as to provide background information about data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventory Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999, EPA promulgated a final rule on persistent bioaccumulative toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.

  11. Acute toxicity and aqueous solubility of some condensed thiophenes and their microbial metabolites

    SciTech Connect (OSTI)

    Seymour, D.T.; Hrudey, S.E.; Fedorak, P.M.; Verbeek, A.G.

    1997-04-01

    Petroleum or creosote contamination of surface waters, soils, or groundwaters introduces countless aromatic compounds to these environments. Among these are condensed thiophenes that were shown to be oxidized to sulfoxides, sulfones, and 2,3-diones by microbial cultures. In this study, the acute toxicities of 12 compounds (benzothiophene, benzothiophene sulfone, benzothiophene-2,3-diones, dibenzothiophene, dibenzothiophene sulfoxide, and dibenzothiophene sulfone) were determined by the Microtox{reg_sign} and Daphnia magna bioassays. To aid in determining the toxicities, the solubilities of many of these compounds were determined, which showed that the oxidized compounds were much more water soluble than the parent thiophenes. In nearly every case, the oxidized compounds were less toxic than their parent thiophenes. The Microtox method was more sensitive than the D. magna bioassay, but in general, there was a good correlation between toxicities measured by the two tests. Samples were removed from batch cultures of a Pseudomonas strain capable of oxidizing the thiophenes, and these samples were subjected to Microtox bioassays. These experiments showed that the toxicities of the culture supernatants decreased with incubation time.

  12. Old, the new, the states, the evolution of the regulation of air toxics. Master's thesis

    SciTech Connect (OSTI)

    Vecera, D.R.

    1993-02-14

    The activism associated with America in the 1960s spilled over into many areas, one of which was a new environmental movement. A product of that movement was the Clean Air Act passed in 1970. The new law included a selection aimed specifically at controlling emissions of hazardous or toxic air pollutants. However, over the next 20 years there was very little government regulation of air toxics, and this section of the Clean Air Act was considered to be a resounding failure. What went wrong. How did this lofty goal to protect human health and the environment end up on the back burner. The article will address the idealism that led to the Clean Air Act legislation, in particular the air toxics program, and explore the realities that scuttled those ideals when it came time to implement the law.

  13. The possibility of garbage, medical and other toxic waste treatment by plasma chemical method

    SciTech Connect (OSTI)

    Rutberg, P.G.; Safronov, A.A.; Bratsev, A.N.; Kuznetsov, V.E.

    1998-12-31

    This paper describes the creation of plasma facility for treatment of toxic waste. All industrialized countries are greatly interested in plasma chemical technology application for the destruction of different types of industrial, building, purification works toxic waste and waste of plants for garbage treatment. On the basis of three-phase plasma generators with power 0.1--1 MW intended for work in air a row of pilot facilities were created for carrying out of experiments on destruction of medical waste and fluorine-chlorine containing substances. The obtained results allow to design and create pilot-commercial plants with treatment productivity of 200 t/24 hours.

  14. Method for screening inhibitors of the toxicity of Bacillus anthracis

    DOE Patents [OSTI]

    Cirino, Nick M. (Los Alamos, NM); Jackson, Paul J. (Los Alamos, NM); Lehnert, Bruce E. (Los Alamos, NM)

    2001-01-01

    The protective antigen (PA) of Bacillus anthracis is integral to the mechanism of anthrax poisoning. The cloning, expression and purification of a 32 kDa B. anthracis PA fragment (PA32) is described. This fragment has also been expressed as a fusion construct to stabilized green fluorescent protein (EGFP-PA32). Both proteins were capable of binding to specific cell surface receptors as determined by fluorescent microscopy and a flow cytometric assay. To confirm binding specificity in the flow cytometric assay, non-fluorescent PA83 or PA32 was used to competitively inhibit fluorescent EGFP-PA32 binding to cell receptors. This assay can be employed as a rapid screen for compounds which disrupts binding of PA to cells. Additionally, the high intracellular expression levels and ease of purification make this recombinant protein an attractive vaccine candidate or therapeutic treatment for anthrax poisoning.

  15. In silico prediction of toxicity of non-congeneric industrial chemicals using ensemble learning based modeling approaches

    SciTech Connect (OSTI)

    Singh, Kunwar P. Gupta, Shikha

    2014-03-15

    Ensemble learning approach based decision treeboost (DTB) and decision tree forest (DTF) models are introduced in order to establish quantitative structuretoxicity relationship (QSTR) for the prediction of toxicity of 1450 diverse chemicals. Eight non-quantum mechanical molecular descriptors were derived. Structural diversity of the chemicals was evaluated using Tanimoto similarity index. Stochastic gradient boosting and bagging algorithms supplemented DTB and DTF models were constructed for classification and function optimization problems using the toxicity end-point in T. pyriformis. Special attention was drawn to prediction ability and robustness of the models, investigated both in external and 10-fold cross validation processes. In complete data, optimal DTB and DTF models rendered accuracies of 98.90%, 98.83% in two-category and 98.14%, 98.14% in four-category toxicity classifications. Both the models further yielded classification accuracies of 100% in external toxicity data of T. pyriformis. The constructed regression models (DTB and DTF) using five descriptors yielded correlation coefficients (R{sup 2}) of 0.945, 0.944 between the measured and predicted toxicities with mean squared errors (MSEs) of 0.059, and 0.064 in complete T. pyriformis data. The T. pyriformis regression models (DTB and DTF) applied to the external toxicity data sets yielded R{sup 2} and MSE values of 0.637, 0.655; 0.534, 0.507 (marine bacteria) and 0.741, 0.691; 0.155, 0.173 (algae). The results suggest for wide applicability of the inter-species models in predicting toxicity of new chemicals for regulatory purposes. These approaches provide useful strategy and robust tools in the screening of ecotoxicological risk or environmental hazard potential of chemicals. - Graphical abstract: Importance of input variables in DTB and DTF classification models for (a) two-category, and (b) four-category toxicity intervals in T. pyriformis data. Generalization and predictive abilities of the constructed (c) DTB and (d) DTF regression models to predict the T. pyriformis toxicity of diverse chemicals. - Highlights: Ensemble learning (EL) based models constructed for toxicity prediction of chemicals Predictive models used a few simple non-quantum mechanical molecular descriptors. EL-based DTB/DTF models successfully discriminated toxic and non-toxic chemicals. DTB/DTF regression models precisely predicted toxicity of chemicals in multi-species. Proposed EL based models can be used as tool to predict toxicity of new chemicals.

  16. Toxic substances from coal combustion -- A comprehensive assessment

    SciTech Connect (OSTI)

    Senior, C.L.; Huggins, F.E.; Huffman, G.P.; Shan, N.; Yap, N.; Wendt, J.O.L.; Seames, W.; Ames, M.R.; Sarofim, A.F.; Swenson, S.; Lighty, J.; Kolker, A.; Finkelman, R.; Palmer, C.; Mroczkowski, S.; Helble, J.; Mamani-Paco, R.; Sterling, R.; Dunham, G.; Miller, S.

    2000-08-17

    The final program review meeting of Phase II was held on June 22 in Salt Lake City. The goals of the meeting were to present work in progress and to identify the remaining critical experiments or analyses, particularly those involving collaboration among various groups. The information presented at the meeting is summarized in this report. Remaining fixed bed, bench-scale experiments at EERC were discussed. There are more ash samples which can be run. Of particular interest are high carbon ash samples to be generated by the University of Arizona this summer and some ash-derived sorbents that EERC has evaluated on a different program. The use of separation techniques (electrostatic or magnetic) was also discussed as a way to understand the active components in the ash with respect to mercury. XAFS analysis of leached and unleached ash samples from the University of Arizona was given a high priority. In order to better understand the fixed bed test results, CCSEM and Moessbauer analyses of those ash samples need to be completed. Utah plans to analyze the ash from the single particle combustion experiments for those major elements not measured by INAA. USGS must still complete mercury analyses on the whole coals and leaching residues. Priorities for further work at the SHRIMP-RG facility include arsenic on ash surfaces and mercury in sulfide minerals. Moessbauer analyses of coal samples from the University of Utah were completed; samples from the top and bottom layers of containers of five different coals showed little oxidation of pyrite in the top relative to the bottom except for Wyodak.

  17. Lethal body concentrations and accumulation patterns determine time-dependent toxicity of cadmium in soil arthropods

    SciTech Connect (OSTI)

    Crommentuijn, T.; Doodeman, C.J.A.M.; Doornekamp, A.; Pol, J.J.C. van der; Bedaux, J.J.M.; Gestel, C.A.M. van )

    1994-11-01

    Time-dependent toxicity in bioassays is usually explained in terms of uptake and elimination kinetics of the toxicant. By comparing different species with essentially different accumulation kinetics, a firm test of this concept may be made. This article compares the sensitivity of six soil arthropods, the collembolans Orchesella cincta and Tomocerus minor, the oribatid mite Platynothrus peltifer, the isopods Porcellio scaber and Oniscus asellus, and the diplopod Cylindroiulus britannicus, when exposed to cadmium in the food. Survival was determined at various time intervals; accumulation of cadmium in the animals was measured at one time interval. Kinetic-based toxicity models were fitted to the data, and estimates were obtained for lethal body concentration, uptake rate constant, elimination rate constant, and ultimate LC50. Two different accumulation patterns could be discerned; these were correlated with time-survival relationships. One, species that have the possibility to eliminate cadmium will reach an equilibrium for the internal concentration and also an ultimate LC50. Two, species that are unable to eliminate cadmium but store it in the body will have an ultimate LC50 equal to zero. For these species the time in which the lethal body concentration is reached is more important. Taxonomically related species appeared to have comparable accumulation patterns, but lethal body concentrations differed. It is concluded that knowledge of the accumulation pattern is indispensable for the evaluation of species' sensitivities to toxicants.

  18. Insights into Acetate Toxicity in Zymomonas mobilis 8b using Different Substrates

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Yang, Shihui; Franden, M. A.; Brown, S. D.; Chou, Y. C.; Pienkos, P. T.; Zhang, Min

    2014-09-30

    The lignocellulosic biomass is a promising renewable feedstock for biofuel production. Acetate is one of the major inhibitors liberated from hemicelluloses during hydrolysis. Likewise, an understanding of the toxic effects of acetate on the fermentation microorganism and the efficient utilization of mixed sugars of glucose and xylose in the presence of hydrolysate inhibitors is crucial for economic biofuel production.

  19. The risk of lead toxicity in homes with lead paint hazard

    SciTech Connect (OSTI)

    Schwartz, J.; Levin, R. )

    1991-02-01

    While lead paint has long been known to be a major source of lead poisoning, only a few small epidemiologic studies have attempted to assess directly the relative risk of lead poisoning due to the presence of lead paint. Using data from over 200,000 screening tests of children in the city of Chicago performed between 1976 and 1980, the relative risks can be quantified for children living in a major urban area. Lead paint was found to be a significant predictor of the probability of a child having lead toxicity. As expected, the reduction in leaded gasoline sales during the period reduced mean blood lead levels and increased the percentage of lead toxic children whose toxicity could be attributed to paint lead. Poisson regression models indicated that with the elimination of leaded gasoline, the relative risk of lead toxicity given lead paint exposure was 5.70 (95% CI, 4.13-7.86) during the winter and fall. The relative risk rose to 12.81 (95% CI, 7.33-22.4) in the spring and 15.8 (95% CI, 8.90-28.1) in the summer, probably due to increased exposure to window wells.

  20. Hypopharyngeal Dose Is Associated With Severe Late Toxicity in Locally Advanced Head-and-Neck Cancer: An RTOG Analysis

    SciTech Connect (OSTI)

    Machtay, Mitchell; Moughan, Jennifer; Farach, Andrew; University of Texas Health Science Center Martin-O'Meara, Elizabeth; Galvin, James; Thomas Jefferson University, Philadelphia, Pennsylvania ; Garden, Adam S.; Weber, Randal S.; Cooper, Jay S.; Forastiere, Arlene; Ang, K. Kian

    2012-11-15

    Purpose: Concurrent chemoradiation therapy (CCRT) for squamous cell carcinoma of the head and neck (SCCHN) increases local tumor control but at the expense of increased toxicity. We recently showed that several clinical/pretreatment factors were associated with the occurrence of severe late toxicity. This study evaluated the potential relationship between radiation dose delivered to the pharyngeal wall and toxicity. Methods and Materials: This was an analysis of long-term survivors from 3 previously reported Radiation Therapy Oncology Group (RTOG) trials of CCRT for locally advanced SCCHN (RTOG trials 91-11, 97-03, and 99-14). Severe late toxicity was defined in this secondary analysis as chronic grade 3-4 pharyngeal/laryngeal toxicity and/or requirement for a feeding tube {>=}2 years after registration and/or potential treatment-related death (eg, pneumonia) within 3 years. Radiation dosimetry (2-dimensional) analysis was performed centrally at RTOG headquarters to estimate doses to 4 regions of interest along the pharyngeal wall (superior oropharynx, inferior oropharynx, superior hypopharynx, and inferior hypopharynx). Case-control analysis was performed with a multivariate logistic regression model that included pretreatment and treatment potential factors. Results: A total of 154 patients were evaluable for this analysis, 71 cases (patients with severe late toxicities) and 83 controls; thus, 46% of evaluable patients had a severe late toxicity. On multivariate analysis, significant variables correlated with the development of severe late toxicity, including older age (odds ratio, 1.062 per year; P=.0021) and radiation dose received by the inferior hypopharynx (odds ratio, 1.023 per Gy; P=.016). The subgroup of patients receiving {<=}60 Gy to the inferior hypopharynx had a 40% rate of severe late toxicity compared with 56% for patients receiving >60 Gy. Oropharyngeal dose was not associated with this outcome. Conclusions: Severe late toxicity following CCRT is common in long-term survivors. Age is the most significant factor, but hypopharyngeal dose also was associated.

  1. High PRF high current switch

    DOE Patents [OSTI]

    Moran, Stuart L. (Fredericksburg, VA); Hutcherson, R. Kenneth (College Park, MD)

    1990-03-27

    A triggerable, high voltage, high current, spark gap switch for use in pu power systems. The device comprises a pair of electrodes in a high pressure hydrogen environment that is triggered by introducing an arc between one electrode and a trigger pin. Unusually high repetition rates may be obtained by undervolting the switch, i.e., operating the trigger at voltages much below the self-breakdown voltage of the device.

  2. Sprague-Dawley rats display metabolism-mediated sex differences in the acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)

    SciTech Connect (OSTI)

    Fonsart, Julien [Universite Paris Descartes, Faculte de Pharmacie, Paris F-75006 (France)]|[CNRS, UMR 7157, Paris F-75006 (France)]|[INSERM, U705, Paris F-75006 (France); Menet, Marie-Claude [Universite Paris Descartes, Faculte de Pharmacie, Paris F-75006 (France)]|[Universite Paris Descartes, Faculte de Pharmacie, Plateau Spectrometrie de Masse (IFR 71), Service de Chimie Analytique, Paris F-75006 (France); Decleves, Xavier [Universite Paris Descartes, Faculte de Pharmacie, Paris F-75006 (France)]|[CNRS, UMR 7157, Paris F-75006 (France)]|[INSERM, U705, Paris F-75006 (France); Galons, Herve [Universite Paris Descartes, Faculte de Pharmacie, Paris F-75006 (France)]|[INSERM, U648, Paris F-75006 (France); Crete, Dominique; Debray, Marcel; Scherrmann, Jean-Michel [Universite Paris Descartes, Faculte de Pharmacie, Paris F-75006 (France)]|[CNRS, UMR 7157, Paris F-75006 (France)]|[INSERM, U705, Paris F-75006 (France); Noble, Florence [Universite Paris Descartes, Faculte de Pharmacie, Paris F-75006 (France)]|[CNRS, UMR 7157, Paris F-75006 (France)]|[INSERM, U705, Paris F-75006 (France)], E-mail: florence.noble@univ-paris5.fr

    2008-07-01

    The use of the amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) has been associated with unexplained deaths. Male humans and rodents are more sensitive to acute toxicity than are females, including a potentially lethal hyperthermia. MDMA is highly metabolized to five main metabolites, by the enzymes CYP1A2 and CYP2D. The major metabolite in rats, 3,4-methylenedioxyamphetamine (MDA), also causes hyperthermia. We postulated that the reported sex difference in rats is due to a sexual dimorphism(s). We therefore determined (1) the LD50 of MDMA and MDA, (2) their hyperthermic effects, (3) the activities of liver CYP1A2 and CYP2D, (4) the liver microsomal metabolism of MDMA and MDA, (5) and the plasma concentrations of MDMA and its metabolites 3 h after giving male and female Sprague-Dawley (SD) rats MDMA (5 mg.kg{sup -1} sc). The LD50 of MDMA was 2.4-times lower in males than in females. MDMA induced greater hyperthermia (0.9 deg. C) in males. The plasma MDA concentration was 1.3-fold higher in males, as were CYP1A2 activity (twice) and N-demethylation to MDA (3.3-fold), but the plasma MDMA concentration (1.4-fold) and CYP2D activity (1.3-fold) were higher in females. These results suggest that male SD rats are more sensitive to MDMA acute toxicity than are females, probably because their CYP1A2 is more active, leading to higher N-demethylation and plasma MDA concentration. This metabolic pathway could be responsible for the lethality of MDMA, as the LD50 of MDA is the same in both sexes. These data strongly suggest that the toxicity of amphetamine-related drugs largely depends on metabolic differences.

  3. Resistance and resilience of pond and stream ecosystems to toxicant stress: Project summary

    SciTech Connect (OSTI)

    Boston, H.L.; Stewart, A.J.; Johnson, A.R.; Bartell, S.M.

    1987-01-01

    This project will evaluate hypotheses concerning the resistance and resilience of aquatic ecosystems exposed to toxic chemicals. Our goals are to develop diagnostic criteria for ecosystem classification and to improve existing methods of ecological risk estimation. The development of models that predict ecosystem level effects requires quantifying the relationships between the underlying control structure of ecosystems (patterns of energy and material flux) and the contributions of thos structures to ecosystem resistance and resilience. We address these problems through an integration of manipulative experiments, multidimensional state space analysis, and ecosystem modeling. These studies will quantify the underlying rate structure in pond and stream systems (including, production, herbivory, nutrient uptake and recycling) and will measure changes in their structures in response to perturbations by toxicants.

  4. Attempt to estimate measurement uncertainty in the Air Force Toxic Chemical Dispersion (AFTOX) model. Master's thesis

    SciTech Connect (OSTI)

    Zettlemoyer, M.D.

    1990-01-01

    The Air Force Toxic Chemical Dispersion (AFTOX) model is a Gaussian puff dispersion model that predicts plumes, concentrations, and hazard distances of toxic chemical spills. A measurement uncertainty propagation formula derived by Freeman et al. (1986) is used within AFTOX to estimate resulting concentration uncertainties due to the effects of data input uncertainties in wind speed, spill height, emission rate, and the horizontal and vertical Gaussian dispersion parameters, and the results are compared to true uncertainties as estimated by standard deviations computed by Monte Carlo simulations. The measurement uncertainty uncertainty propagation formula was found to overestimate measurement uncertainty in AFTOX-calculated concentrations by at least 350 percent, with overestimates worsening with increasing stability and/or increasing measurement uncertainty.

  5. Toxic Substances Control Act Uranium Enrichment Federal Facilities Compliance Agreement, February 20, 1992 Summary

    Office of Environmental Management (EM)

    Toxic Substance Control Act Uranium Enrichment Federal Facilities Compliance Agreement (TSCA-UE- FFCA), February 20, 1992 State Kentucky Agreement Type Compliance Agreement Legal Driver(s) TSCA Scope Summary Establishes responsibilities and commitments for bringing DOE's former and active Uranium Enrichment Plants in Paducah, Portsmouth, and Oak Ridge into compliance with TSCA and PCB Regulations Parties DOE; U.S. EPA Date 2/20/1992 SCOPE * Establish a plan and the responsibilities and

  6. Toxic Substances Control Act Uranium Enrichment Federal Facilities Compliance Agreement, February 20, 1992 Summary

    Office of Environmental Management (EM)

    Toxic Substance Control Act Uranium Enrichment Federal Facilities Compliance Agreement (TSCA-UE- FFCA), February 20, 1992 State Ohio Agreement Type Compliance Agreement Legal Driver(s) TSCA Scope Summary Establishes responsibilities and commitments for bringing DOE's former and active Uranium Enrichment Plants in Paducah, Portsmouth, and Oak Ridge into compliance with TSCA and PCB Regulations Parties DOE; U.S. EPA Date 2/20/1992 SCOPE * Establish a plan and the responsibilities and commitments

  7. Environmental Guidance Program reference book: Toxic substances control act. Revision 7

    SciTech Connect (OSTI)

    1994-12-01

    This Reference Book contains a current copy of the Toxic Substances Control Act and those regulations that implement the statute and appear to be most relevant to DOE activities. The document is provided to DOE staff for informational purposes only and should not be interpreted as legal guidance. Questions concerning this Reference Book may be directed to Mark Petts, EH-231 (202/586-2609).

  8. Toxic Substances Control Act. Environmental Guidance Program Reference Book: Revision 6

    SciTech Connect (OSTI)

    Not Available

    1992-05-15

    This Reference Book contains a current copy of the Toxic Substances Control Act and those regulations that implement the statute and appear to be most relevant to DOE activities. The document is provided to DOE and contractor staff for informational purposes only and should not be interpreted as legal guidance. Questions concerning this Reference Book may be directed to Mark Petts, EH-231 (202/586-2609).

  9. New Tool for Studying Toxic Metals in the Environment | U.S. DOE Office of

    Office of Science (SC) Website

    Science (SC) New Tool for Studying Toxic Metals in the Environment Biological and Environmental Research (BER) BER Home About Research Facilities Science Highlights Searchable Archive of BER Highlights External link Benefits of BER Funding Opportunities Biological & Environmental Research Advisory Committee (BERAC) Community Resources Contact Information Biological and Environmental Research U.S. Department of Energy SC-23/Germantown Building 1000 Independence Ave., SW Washington, DC

  10. Lethal and sublethal measures of chronic copper toxicity in the eastern narrowmouth toad, Gastrophryne carolinensis

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    LETHAL AND SUBLETHAL MEASURES OF CHRONIC COPPER TOXICITY IN THE EASTERN NARROWMOUTH TOAD, GASTROPHRYNE CAROLINENSIS R. WESLEY FLYNN,*y DAVID E. SCOTT,y WENDY KUHNE,zx DIANA SOTEROPOULOS,y and STACEY L. LANCEx ySavannah River Ecology Laboratory, University of Georgia, Aiken, South Carolina, USA zSavannah River National Laboratory, Department of Energy, University of Georgia,, Aiken, South Carolina, USA xDepartment of Biology, University of South Carolina-Aiken, Aiken, South Carolina, USA

  11. Identifying Biomarkers and Mechanisms of Toxic Metal Stress with Global Proteomics

    SciTech Connect (OSTI)

    Miller, Susan M.

    2012-04-16

    Hg is a wide-spread contaminant in the environment and is toxic in all of its various forms. Data suggest that RHg+ and Hg2+ are toxic in two ways. At low levels, Hg species appear to disrupt membrane-bound respiration causing a burst of reactive oxygen species (ROS) that further damage the cell. At higher Hg concentrations, RHg+ and Hg2+ may form adducts with cysteine- and selenocysteine-containing proteins in all cellular compartments resulting in their inactivation. Although these mechansims for toxicity are generally accepted, the most sensitive targets associated with these mechanisms are not well understood. In this collaborative project involving three laboratories at three institutions, the overall goal was to develop of a mass spectrometry-based global proteomics methodology that could be used to identify Hg-adducted (and ideally, ROS-damaged) proteins in order to address these types of questions. The two objectives of this overall collaborative project were (1) to identify, quantify, and compare ROS- and Hg-damaged proteins in cells treated with various Hg species and concentrations to test this model for two mechanisms of Hg toxicity, and (2) to define the cellular roles of the ubiquitous bacterial mercury resistance (mer) locus with regards to how the proteins of this pathway interact to protect other cell proteins from Hg damage. The specific objectives and accomplishments of the Miller lab in this project included: (1) Development of algorithms for analysis of the Hg-proteomic mass spectrometry data to identify mercury adducted peptides and other trends in the data. (2) Investigation of the role of mer operon proteins in scavenging Hg(II) from other mer pathway proteins as a means of protecting cellular proteins from damage.

  12. Ligand-specific transcriptional mechanisms underlie aryl hydrocarbon receptor-mediated developmental toxicity of oxygenated PAHs

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Goodale, B. C.; Geisel School of Medicine at Dartmouth, Hanover, NH; La Du, J.; Tilton, S. C.; Pacific Northwest National Lab.; Sullivan, C. M.; Bisson, W. H.; Waters, K. M.; Tanguay, R. L.

    2015-07-03

    Polycyclic aromatic hydrocarbons (PAHs) are priority environmental contaminants that exhibit mutagenic, carcinogenic, proinflammatory, and teratogenic properties. Oxygen-substituted PAHs (OPAHs) are formed during combustion processes and via phototoxidation and biological degradation of parent (unsubstituted) PAHs. Despite their prevalence both in contaminated industrial sites and in urban air, OPAH mechanisms of action in biological systems are relatively understudied. Like parent PAHs, OPAHs exert structure-dependent mutagenic activities and activation of the aryl hydrocarbon receptor (AHR) and cytochrome p450 metabolic pathway. Four-ring OPAHs 1,9-benz-10-anthrone (BEZO) and benz(a)anthracene-7,12-dione (7,12-B[a]AQ) cause morphological aberrations and induce markers of oxidative stress in developing zebrafish with similar potency, butmore » only 7,12-B[a]AQ induces robust Cyp1a protein expression. We investigated the role of the AHR in mediating the toxicity of BEZO and 7,12-B[a]AQ, and found that knockdown of AHR2 rescued developmental effects caused by both compounds. Using RNA-seq and molecular docking, we identified transcriptional responses that precede developmental toxicity induced via differential interaction with AHR2. Redox-homeostasis genes were affected similarly by these OPAHs, while 7,12-B[a]AQ preferentially activated phase 1 metabolism and BEZO uniquely decreased visual system genes. Analysis of biological functions and upstream regulators suggests that BEZO is a weak AHR agonist, but interacts with other transcriptional regulators to cause developmental toxicity in an AHR-dependent manner. Furthermore, identifying ligand-dependent AHR interactions and signaling pathways is essential for understanding toxicity of this class of environmentally relevant compounds.« less

  13. Predictors of Severe Acute and Late Toxicities in Patients With Localized Head-and-Neck Cancer Treated With Radiation Therapy

    SciTech Connect (OSTI)

    Meyer, Francois, E-mail: francois.meyer@chuq.qc.ca [Laval University Cancer Research Center, Centre hospitalier universitaire de Quebec - L'Hotel-Dieu de Quebec, Quebec (Canada); Fortin, Andre; Wang, Chang Shu [Radiation Therapy Department, Centre hospitalier universitaire de Quebec - L'Hotel-Dieu de Quebec, Quebec (Canada); Liu, Geoffrey [Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto (Canada); Bairati, Isabelle [Laval University Cancer Research Center, Centre hospitalier universitaire de Quebec - L'Hotel-Dieu de Quebec, Quebec (Canada)

    2012-03-15

    Purpose: Radiation therapy (RT) causes acute and late toxicities that affect various organs and functions. In a large cohort of patients treated with RT for localized head and neck cancer (HNC), we prospectively assessed the occurrence of RT-induced acute and late toxicities and identified characteristics that predicted these toxicities. Methods and Materials: We conducted a randomized trial among 540 patients treated with RT for localized HNC to assess whether vitamin E supplementation could improve disease outcomes. Adverse effects of RT were assessed using the Radiation Therapy Oncology Group Acute Radiation Morbidity Criteria during RT and one month after RT, and the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer Late Radiation Morbidity Scoring Scheme at six and 12 months after RT. The most severe adverse effect among the organs/tissues was selected as an overall measure of either acute or late toxicity. Grade 3 and 4 toxicities were considered as severe. Stepwise multivariate logistic regression models were used to identify all independent predictors (p < 0.05) of acute or late toxicity and to estimate odds ratios (OR) for severe toxicity with their 95% confidence intervals (CI). Results: Grade 3 or 4 toxicity was observed in 23% and 4% of patients, respectively, for acute and late toxicity. Four independent predictors of severe acute toxicity were identified: sex (female vs. male: OR = 1.72, 95% confidence interval [CI]: 1.06-2.80), Karnofsky Performance Status (OR = 0.67 for a 10-point increment, 95% CI: 0.52-0.88), body mass index (above 25 vs. below: OR = 1.88, 95% CI: 1.22-2.90), TNM stage (Stage II vs. I: OR = 1.91, 95% CI: 1.25-2.92). Two independent predictors were found for severe late toxicity: female sex (OR = 3.96, 95% CI: 1.41-11.08) and weight loss during RT (OR = 1.26 for a 1 kg increment, 95% CI: 1.12-1.41). Conclusions: Knowledge of these predictors easily collected in a clinical setting could help tailoring therapies to reduce toxicities among patients treated with RT for HNC.

  14. Air toxics provisions of the Clean Air Act: Potential impacts on energy

    SciTech Connect (OSTI)

    Hootman, H.A.; Vernet, J.E.

    1991-11-01

    This report provides an overview of the provisions of the Clean Air Act and its Amendments of 1990 that identify hazardous air pollutant (HAP) emissions and addresses their regulation by the US Environmental Protection Agency (EPA). It defines the major energy sector sources of these HAPs that would be affected by the regulations. Attention is focused on regulations that would cover coke oven emissions; chromium emission from industrial cooling towers and the electroplating process; HAP emissions from tank vessels, asbestos-related activities, organic solvent use, and ethylene oxide sterilization; and emissions of air toxics from municipal waste combustors. The possible implications of Title III regulations for the coal, natural gas, petroleum, uranium, and electric utility industries are examined. The report discusses five major databases of HAP emissions: (1) TRI (EPA`s Toxic Release Inventory); (2) PISCES (Power Plant Integrated Systems: Chemical Emissions Studies developed by the Electric Power Research Institute); (3) 1985 Emissions Inventory on volatile organic compounds (used for the National Acid Precipitation Assessment Program); (4) Particulate Matter Species Manual (EPA); and (5) Toxics Emission Inventory (National Aeronautics and Space Administration). It also offers information on emission control technologies for municipal waste combustors.

  15. Air toxics provisions of the Clean Air Act: Potential impacts on energy

    SciTech Connect (OSTI)

    Hootman, H.A.; Vernet, J.E.

    1991-11-01

    This report provides an overview of the provisions of the Clean Air Act and its Amendments of 1990 that identify hazardous air pollutant (HAP) emissions and addresses their regulation by the US Environmental Protection Agency (EPA). It defines the major energy sector sources of these HAPs that would be affected by the regulations. Attention is focused on regulations that would cover coke oven emissions; chromium emission from industrial cooling towers and the electroplating process; HAP emissions from tank vessels, asbestos-related activities, organic solvent use, and ethylene oxide sterilization; and emissions of air toxics from municipal waste combustors. The possible implications of Title III regulations for the coal, natural gas, petroleum, uranium, and electric utility industries are examined. The report discusses five major databases of HAP emissions: (1) TRI (EPA's Toxic Release Inventory); (2) PISCES (Power Plant Integrated Systems: Chemical Emissions Studies developed by the Electric Power Research Institute); (3) 1985 Emissions Inventory on volatile organic compounds (used for the National Acid Precipitation Assessment Program); (4) Particulate Matter Species Manual (EPA); and (5) Toxics Emission Inventory (National Aeronautics and Space Administration). It also offers information on emission control technologies for municipal waste combustors.

  16. Inhalation developmental toxicology studies: Developmental toxicity of chloroprene vapors in New Zealand white rabbits. Final report

    SciTech Connect (OSTI)

    Mast, T.J.; Evanoff, J.J.; Westerberg, R.B.; Rommereim, R.L.; Weigel, R.J.

    1994-04-01

    Chloroprene, 2-chloro-1,3-butadiene, is a colorless liquid with a pungent ethereal odor that is primarily used as an intermediate in the manufacture of neoprene rubber, and has been used as such since about 1930. This study addressed the potential for chloroprene to cause developmental toxicity in New Zealand white rabbits following gestational exposure to 0, 10, 40, or 175 ppm chloroprene vapors, 6h/dy, 7dy/wk. Each treatment group consisted of 15 artificially inseminated females exposed on 6 through 28 days of gestation (dg). Body weights were obtained throughout the study period, and uterine and fetal body weights were obtained at sacrifice on 29 dg. Implants were enumerated and their status recorded and live fetuses were examined for gross, visceral, skeletal, and soft-tissue craniofacial defects. There were no overt signs of maternal toxicity and the change in maternal body weight over the course of the study was not affected. Exposure of pregnant rabbits to chloroprene vapors on 6-28 dg had no effect on the number of implantation, the mean percent of live pups per litter, or on the incidence of resorptions per litter. The incidence of fetal malformations was not increased by exposure to chloroprene. Results of this study indicate that gestational exposure of New Zealand white rabbits to 10, 40, or 175 ppm chloroprene did not result in observable toxicity to either the dam or the offspring.

  17. Five-Year Outcomes, Cosmesis, and Toxicity With 3-Dimensional Conformal External Beam Radiation Therapy to Deliver Accelerated Partial Breast Irradiation

    SciTech Connect (OSTI)

    Rodrguez, Nria; Sanz, Xavier; Dengra, Josefa; Foro, Palmira; Membrive, Ismael; Reig, Anna; Quera, Jaume; Fernndez-Velilla, Enric; Pera, scar; Lio, Jackson; Lozano, Joan; Algara, Manuel

    2013-12-01

    Purpose: To report the interim results from a study comparing the efficacy, toxicity, and cosmesis of breast-conserving treatment with accelerated partial breast irradiation (APBI) or whole breast irradiation (WBI) using 3-dimensional conformal external beam radiation therapy (3D-CRT). Methods and Materials: 102 patients with early-stage breast cancer who underwent breast-conserving surgery were randomized to receive either WBI (n=51) or APBI (n=51). In the WBI arm, 48 Gy was delivered to the whole breast in daily fractions of 2 Gy, with or without additional 10 Gy to the tumor bed. In the APBI arm, patients received 37.5 Gy in 3.75 Gy per fraction delivered twice daily. Toxicity results were scored according to the Radiation Therapy Oncology Group Common Toxicity Criteria. Skin elasticity was measured using a dedicated device (Multi-Skin-Test-Center MC-750-B2, CKelectronic-GmbH). Cosmetic results were assessed by the physician and the patients as good/excellent, regular, or poor. Results: The median follow-up time was 5 years. No local recurrences were observed. No significant differences in survival rates were found. APBI reduced acute side effects and radiation doses to healthy tissues compared with WBI (P<.01). Late skin toxicity was no worse than grade 2 in either group, without significant differences between the 2 groups. In the ipsilateral breast, the areas that received the highest doses (ie, the boost or quadrant) showed the greatest loss of elasticity. WBI resulted in a greater loss of elasticity in the high-dose area compared with APBI (P<.05). Physician assessment showed that >75% of patients in the APBI arm had excellent or good cosmesis, and these outcomes appear to be stable over time. The percentage of patients with excellent/good cosmetic results was similar in both groups. Conclusions: APBI delivered by 3D-CRT to the tumor bed for a selected group of early-stage breast cancer patients produces 5-year results similar to those achieved with conventional WBI.

  18. Quality of Life and Toxicity From Passively Scattered and Spot-Scanning Proton Beam Therapy for Localized Prostate Cancer

    SciTech Connect (OSTI)

    Pugh, Thomas J. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Munsell, Mark F. [Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Choi, Seungtaek; Nguyen, Quyhn Nhu; Mathai, Benson [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Zhu, X. Ron; Sahoo, Narayan; Gillin, Michael; Johnson, Jennifer L.; Amos, Richard A. [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Dong, Lei [Scripps Proton Therapy Center, San Diego, California (United States); Mahmood, Usama; Kuban, Deborah A.; Frank, Steven J.; Hoffman, Karen E.; McGuire, Sean E. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lee, Andrew K., E-mail: aklee@mdanderson.org [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2013-12-01

    Purpose: To report quality of life (QOL)/toxicity in men treated with proton beam therapy for localized prostate cancer and to compare outcomes between passively scattered proton therapy (PSPT) and spot-scanning proton therapy (SSPT). Methods and Materials: Men with localized prostate cancer enrolled on a prospective QOL protocol with a minimum of 2 years' follow-up were reviewed. Comparative groups were defined by technique (PSPT vs SSPT). Patients completed Expanded Prostate Cancer Index Composite questionnaires at baseline and every 3-6 months after proton beam therapy. Clinically meaningful differences in QOL were defined as ?0.5 baseline standard deviation. The cumulative incidence of modified Radiation Therapy Oncology Group grade ?2 gastrointestinal (GI) or genitourinary (GU) toxicity and argon plasma coagulation were determined by the Kaplan-Meier method. Results: A total of 226 men received PSPT, and 65 received SSPT. Both PSPT and SSPT resulted in statistically significant changes in sexual, urinary, and bowel Expanded Prostate Cancer Index Composite summary scores. Only bowel summary, function, and bother resulted in clinically meaningful decrements beyond treatment completion. The decrement in bowel QOL persisted through 24-month follow-up. Cumulative grade ?2 GU and GI toxicity at 24 months were 13.4% and 9.6%, respectively. There was 1 grade 3 GI toxicity (PSPT group) and no other grade ?3 GI or GU toxicity. Argon plasma coagulation application was infrequent (PSPT 4.4% vs SSPT 1.5%; P=.21). No statistically significant differences were appreciated between PSPT and SSPT regarding toxicity or QOL. Conclusion: Both PSPT and SSPT confer low rates of grade ?2 GI or GU toxicity, with preservation of meaningful sexual and urinary QOL at 24 months. A modest, yet clinically meaningful, decrement in bowel QOL was seen throughout follow-up. No toxicity or QOL differences between PSPT and SSPT were identified. Long-term comparative results in a larger patient cohort are warranted.

  19. WE-D-BRE-03: Late Toxicity Following Photon Or Proton Radiotherapy in Patients with Brain Tumors

    SciTech Connect (OSTI)

    Munbodh, R; Ding, X; Yin, L; Anamalayil, S; Dorsey, J; Lustig, R; Alonso-Basanta, M

    2014-06-15

    Purpose: To identify indicators of Late Grade 3 (LG3) toxicity, late vision and hearing changes in patients treated for primary brain tumors with photon (XRT) or proton radiotherapy (PRT). Methods: We retrospectively reviewed 102 patients who received brain XRT or PRT to doses of 54 or 59.6 Gy in daily fractions of 1.8–2 Gy. Of the 80 patients (34 XRT, 39 PRT and 7 both modalities) reviewed for indicators of LG3 toxicity, 25 developed LG3 toxicity 90 to 500 days after radiotherapy completion. 55 patients had less than LG3 toxicity > 500 days after treatment. In that time, late vision and hearing changes were seen in 44 of 75 and 25 of 78 patients, respectively. The correlation between late toxicity and prescription dose, planning target volume (PTV) size, and doses to the brainstem, brain, optic chiasm, optic nerves, eyes and cochlea was evaluated. A two-tailed Fisher's exact test and Wilcoxon rank sum test were used for the statistical analysis for XRT, PRT and all patients combined. Results: Exceeding the 54 Gy-5% dose-volume brainstem constraint, but not the optic structure constraints, was significantly correlated (p < 0.05) with late vision changes in all three groups. Exceeding maximum and mean cochlear doses of 45 and 30 Gy, respectively, was a significant indicator of hearing changes (p < 0.05) in PRT patients and all patients combined. In a sub-group of 52 patients in whom the brain was contoured, the absolute brain volume receiving ≤ 50 Gy and > 60 Gy was significantly larger in patients with LG3 toxicity for all patients combined (p < 0.05). Prescription dose, brainstem dose and PTV volume were not correlated to LG3 toxicity. Conclusion: Our results indicate the importance of minimizing the brain volume irradiated, and brainstem and cochlea doses to reduce the risk of late toxicities following brain radiotherapy.

  20. Migration and Retardation of Chemical Toxic Components from Radioactive Waste - Hydrochemical Aspects

    SciTech Connect (OSTI)

    Jedinakova-Krizova, V.; Hanslik, E.

    2003-02-24

    A systematic analysis of nuclear power plant (NPP) operation and radioactive wastes disposal (near-surface disposal and geologic disposal) in underground repositories has provided the basis for a comparison between the radiotoxicity and chemotoxicity as part of an EIA (environmental impact assessment) procedure. This contribution summarizes the hydrochemical mechanisms of transport and retardation processes, chemistry and migration behavior of radionuclides and chemical toxics in natural sorbents, especially bentonites. The effect of solubility and dissolution reactions, diffusion and sorption/desorption, complexation and variations in the aqueous phase composition, pH-value and oxidation-reduction properties and other phenomena affecting distribution coefficients (Kd values) is discussed.

  1. Acute environmental toxicity and persistence of methyl salicylate: A chemical agent simulant. Final report

    SciTech Connect (OSTI)

    Cataldo, D.A.; Ligotke, M.W.; Harvey, S.D.; Fellows, R.J.; Li, S.W.

    1994-06-01

    The interactions of methyl salicylate with plant foliage and soils were assessed using aerosol/vapor exposure methods. Measurements of deposition velocity and residence times for soils and foliar surfaces are reported. Severe plant contact toxicity was observed at foliar mass-loading levels above 4 {mu}g/cm{sup 2} leaf; however, recovery was noted after four to fourteen days. Methyl salicylate has a short-term effect on soil dehydrogenase activity, but not phosphatase activity. Results of the earthworm bioassay indicated only minimal effects on survival.

  2. Molecular Mimicry of SUMO by Rad60 Helps Protect the Genome from Toxic

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Stress Molecular Mimicry of SUMO by Rad60 Helps Protect the Genome from Toxic Stress DNA is subject to multiple forms of damage that can occur either spontaneously, through sources such as reactive oxygen species produced by cellular metabolism, or through exogenous sources such as UV light and X-rays. Different cellular pathways exist to detect and repair the distinct forms of damage, and thus maintain the stability of the genome. The importance of the DNA repair pathways is highlighted by

  3. Control of Toxic Chemicals in Puget Sound, Phase 3: Study of Atmospheric Deposition of Air Toxics to the Surface of Puget Sound

    SciTech Connect (OSTI)

    Brandenberger, Jill M.; Louchouarn, Patrick; Kuo, Li-Jung; Crecelius, Eric A.; Cullinan, Valerie I.; Gill, Gary A.; Garland, Charity R.; Williamson, J. B.; Dhammapala, R.

    2010-07-05

    The results of the Phase 1 Toxics Loading study suggested that runoff from the land surface and atmospheric deposition directly to marine waters have resulted in considerable loads of contaminants to Puget Sound (Hart Crowser et al. 2007). The limited data available for atmospheric deposition fluxes throughout Puget Sound was recognized as a significant data gap. Therefore, this study provided more recent or first reported atmospheric deposition fluxes of PAHs, PBDEs, and select trace elements for Puget Sound. Samples representing bulk atmospheric deposition were collected during 2008 and 2009 at seven stations around Puget Sound spanning from Padilla Bay south to Nisqually River including Hood Canal and the Straits of Juan de Fuca. Revised annual loading estimates for atmospheric deposition to the waters of Puget Sound were calculated for each of the toxics and demonstrated an overall decrease in the atmospheric loading estimates except for polybrominated diphenyl ethers (PBDEs) and total mercury (THg). The median atmospheric deposition flux of total PBDE (7.0 ng/m2/d) was higher than that of the Hart Crowser (2007) Phase 1 estimate (2.0 ng/m2/d). The THg was not significantly different from the original estimates. The median atmospheric deposition flux for pyrogenic PAHs (34.2 ng/m2/d; without TCB) shows a relatively narrow range across all stations (interquartile range: 21.2- 61.1 ng/m2/d) and shows no influence of season. The highest median fluxes for all parameters were measured at the industrial location in Tacoma and the lowest were recorded at the rural sites in Hood Canal and Sequim Bay. Finally, a semi-quantitative apportionment study permitted a first-order characterization of source inputs to the atmosphere of the Puget Sound. Both biomarker ratios and a principal component analysis confirmed regional data from the Puget Sound and Straits of Georgia region and pointed to the predominance of biomass and fossil fuel (mostly liquid petroleum products such as gasoline and/or diesel) combustion as source inputs of combustion by-products to the atmosphere of the region and subsequently to the waters of Puget Sound.

  4. High e

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    e ne rgy data s am ple ● NuMI beam events provide an useful calibration sample ● Collected over 70K candidates before shutdown The highest energy events are prim arily from kaon decays. Two sam ples at high energy provide normalization and shape inform ation for kaon backgrounds to oscillation analysis: ● ν e events passing oscillation event selection cuts ● ν µ induced CCQE, CCπ+events Reconstructed neutrino energy EνQE(GeV) ν from other particles ν from pions ν from Kaons -

  5. Evaluation of 2,3,7,8 specific congener and toxic potency of persistent polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in cetaceans from the Mediterranean Sea, Italy

    SciTech Connect (OSTI)

    Jimenez, B.; Gonzalez, M.J.; Jimenez, O.; Reich, S.; Eljarrat, E.; Rivera, J.

    2000-03-01

    The present study investigates individual 2,3,7,8-substituted polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF) concentrations in cetaceans and assesses the PCDD and PCDF contributions to the total TCDD equivalent concentration. Liver samples of a variety of cetaceans species found stranded along the Italian coasts during the period of 1987--1992 were analyzed for PCDDs and PCDFs. The main aims were to scrutinize levels and patterns of PCDDs and PCDFs for the first time in cetaceans from the Mediterranean Sea and to estimate whether chlorinated compounds mentioned are implicated in the exceptionally high mortality of dolphins that occurred in the Mediterranean sea during 1990--1992. PCDD and PCDF profiles were dominated by congeners OCCD and OCDF. The new toxic equivalency factors recommended by WHO in 1997 were used for calculation of dioxin-like toxicity. On the basis of their previous study of PCBs, the overall TEQ calculated from the 2,3,7,8-substituted PCDDs and PCDFs do not contribute as much dioxin-like toxicity as PCBs.

  6. Determination of the toxicity characteristic for metals in soil: A comparison of the toxicity characteristic leaching procedure and total metal determination

    SciTech Connect (OSTI)

    Bass, D.A.; Taylor, J.D.

    1994-12-01

    A comparison is made of the concentrations of metals extracted from soils using the Toxicity Characteristic Leaching Procedure (TCLP) and a total determination method. This information is of interest in two ways. First, it is hoped that a relationship might be established between the amount of each metal determined after extraction by the TCLP and the amount determined using a total determination method. And second, data are also presented which indicate the general extractability of various metals in soil samples using the TCLP. This study looks specifically at inorganic elements (Sb, As, Ba, Cd, Cu, Cr, Pb, Mg, Hg, Se, Ag, Sn, and Zn) in soils from a firing range. Results show that total determination methods for metals can not generally be used for heterogeneous samples, such as soil samples from a firing range. Some correlation between a total determination method and TCLP was observed when Ba and Cd were present in the samples at lower concentrations (less than 80 mg/kg for Ba and less than 25 mg/kg for Cd); however, additional data are necessary to verify this correlation.

  7. Hyperfractionated Accelerated Radiotherapy (HART) for Anaplastic Thyroid Carcinoma: Toxicity and Survival Analysis

    SciTech Connect (OSTI)

    Dandekar, Prasad; Rhys-Evans, Peter; Harrington, Kevin; Nutting, Christopher; Newbold, Kate

    2009-06-01

    Purpose: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive cancers, and the current protocol of hyperfractionated accelerated radiotherapy was initiated to improve survival while limiting toxicities. Methods and Materials: All patients with ATC from 1991 to 2002 were accrued and received megavoltage radiotherapy from the mastoid processes to the carina up to 60 Gy in twice-daily fractions of 1.8 and 2 Gy, 6 hours apart. Results: Thirty-one patients were accrued with a median age of 69 years, and 55% were women. Debulking was performed in 26%, and total thyroidectomy, in 6%, whereas 68% received radical radiotherapy alone. Local control data were available for 27 patients: 22% had a complete response, 26% had a partial response, 15% showed progressive disease, and 37% showed static disease. Median overall survival for all 31 patients was 70 days (95% confidence interval, 40-99). There was no significant difference in median survival between patients younger (70 days) and older than 70 years (42 days), between men (70 days) and women (49days), and between patients receiving postoperative radiotherapy (77 days) and radical radiotherapy alone (35 days). Grade III or higher skin erythema was seen in 56% patients; desquamation in 21%; dysphagia in 74%; and esophagitis in 79%. Conclusion: The current protocol failed to offer a significant survival benefit, was associated with severe toxicities, and thus was discontinued. There is a suggestion that younger patients with operable disease have longer survival, but this would require a larger study to confirm it.

  8. Toxicity of Select Organic Acids to the Slightly Thermophilic Acidophile Acidithiobaccillus Caldus

    SciTech Connect (OSTI)

    John E Aston; William A Apel; Brady D Lee; Brent M Peyton

    2009-02-01

    Acidithiobacillus caldus is a thermophilic acidophile found in commercial biomining, acid mine drainage systems, and natural environments. Previous work has characterized A. caldus as a chemolithotrophic autotroph capable of utilizing reduced sulfur compounds under aerobic conditions. Organic acids are especially toxic to chemolithotrophs in low-pH environments, where they diffuse more readily into the cell and deprotonate within the cytoplasm. In the present study, the toxic effects of oxaloacetate, pyruvate, 2-ketoglutarate, acetate, malate, succinate, and fumarate on A. caldus strain BC13 were examined under batch conditions. All tested organic acids exhibited some inhibitory effect. Oxaloacetate was observed to inhibit growth completely at a concentration of 250 M, whereas other organic acids were completely inhibitory at concentrations of between 1,000 and 5,000 M. In these experiments, the measured concentrations of organic acids decreased with time, indicating uptake or assimilation by the cells. Phospholipid fatty acid analyses indicated an effect of organic acids on the cellular envelope. Notable differences included an increase in cyclic fatty acids in the presence of organic acids, indicating possible instability of the cellular envelope. This was supported by field emission scanning-electron micrographs showing blebbing and sluffing in cells grown in the presence of organic acids.

  9. ABB`s investigations into air toxic emissions from fossil fuel and MSW combustion

    SciTech Connect (OSTI)

    Wesnor, J.D.

    1994-12-31

    Since passage of the Clean Air Act, Asea Brown Boveri (ABB) has been actively developing a knowledge base on the Title 3 hazardous air pollutants, more commonly called air toxics. As ABB is a multinational company, US operating companies are able to call upon work performed by European counterparts, who have faced similar legislation several years ago. In addition to the design experience and database acquired in Europe, ABB Inc. has been pursuing several other avenues to expand its air toxics knowledge. ABB Combustion Engineering (ABB CE) is presently studying the formation of organic pollutants within the combustion furnace and partitioning of trace metals among the furnace outlet streams. ABB Environmental Systems (ABBES) has reviewed available and near-term control technologies and methods. Also, both ABB CE and ABBES have conducted source sampling and analysis at commercial installations for hazardous air pollutants to determine the emission rates and removal performance of various types of equipment. Several different plants hosted these activities, allowing for variation in fuel type and composition, boiler configuration, and air pollution control equipment. This paper discusses the results of these investigations.

  10. Structure-toxicity assessment of metabolites of the aerobic bacterial transformation of substituted naphthalenes

    SciTech Connect (OSTI)

    LeBlond, J.D.; Applegate, B.M.; Menn, F.M.; Schultz, T.W.; Sayler, G.S.

    2000-05-01

    Pseudomonas fluorescens 5R, a naphthalene-degrading bacterium isolated from manufactured gas plant soil contaminated with polycyclic aromatic hydrocarbons, was examined for its degradative capacity of a number of substituted naphthalenes. In general, those compounds substituted on only one ring with an electrically neutral substituent were found to be transformed primarily to substituted salicylic acids according to the classical (NAH7) naphthalene dioxygenase-initiated upper pathway reactions of the naphthalene degradative pathway (i.e., the NAH system). Dimethylnaphthalenes with a substituent on each ring, and certain halogenated naphthalenes, were transformed via a monohydroxylation reaction to form hydroxylated dead-end products. Of the substituted salicylic acids examined, only 3- and 4-methylsalicylic acid, the respective products of the degradation of 1- and 2-methylnaphthalene, were further degraded by salicylate hydroxylase and catechol 2,3-dioxygenase, the first two enzymes of the NAH lower pathway. Using the Tetrahymena pyriformis acute toxicity assay, many of the monohydroxylated products of incomplete biodegradation were found to be polar narcotics. Substituted salicylic acids that are not further degraded by the NAH lower pathway were found to be toxic via carboxylic acid narcosis.

  11. Small heat shock proteins protect against {alpha}-synuclein-induced toxicity and aggregation

    SciTech Connect (OSTI)

    Outeiro, Tiago Fleming [Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH, Harvard Medical School, CNY 114, 16th Street, Charlestown, MA 02129 (United States); Klucken, Jochen [Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH, Harvard Medical School, CNY 114, 16th Street, Charlestown, MA 02129 (United States); Strathearn, Katherine E. [Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907-2091 (United States); Liu Fang [Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907-2091 (United States); Nguyen, Paul [Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH, Harvard Medical School, CNY 114, 16th Street, Charlestown, MA 02129 (United States); Rochet, Jean-Christophe [Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907-2091 (United States); Hyman, Bradley T. [Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH, Harvard Medical School, CNY 114, 16th Street, Charlestown, MA 02129 (United States); McLean, Pamela J. [Alzheimer's Research Unit, MassGeneral Institute for Neurodegenerative Disease, MGH, Harvard Medical School, CNY 114, 16th Street, Charlestown, MA 02129 (United States)]. E-mail: touteiro@partners.org

    2006-12-22

    Protein misfolding and inclusion formation are common events in neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD) or Huntington's disease (HD). {alpha}-Synuclein (aSyn) is the main protein component of inclusions called Lewy bodies (LB) which are pathognomic of PD, Dementia with Lewy bodies (DLB), and other diseases collectively known as LB diseases. Heat shock proteins (HSPs) are one class of the cellular quality control system that mediate protein folding, remodeling, and even disaggregation. Here, we investigated the role of the small heat shock proteins Hsp27 and {alpha}B-crystallin, in LB diseases. We demonstrate, via quantitative PCR, that Hsp27 messenger RNA levels are {approx}2-3-fold higher in DLB cases compared to control. We also show a corresponding increase in Hsp27 protein levels. Furthermore, we found that Hsp27 reduces aSyn-induced toxicity by {approx}80% in a culture model while {alpha}B-crystallin reduces toxicity by {approx}20%. In addition, intracellular inclusions were immunopositive for endogenous Hsp27, and overexpression of this protein reduced aSyn aggregation in a cell culture model.

  12. Chronomodulation of topotecan or X-radiation treatment increases treatment efficacy without enhancing acute toxicity

    SciTech Connect (OSTI)

    Mullins, Dana; Proulx, Denise; Saoudi, A.; Ng, Cheng E. . E-mail: cng@ohri.ca

    2005-05-01

    Purpose: Topotecan (TPT), a camptothecin analog, is currently used to treat human ovarian and small-cell lung cancer and is in clinical trials for other tumor sites. However, it is unknown whether chronomodulation of TPT treatment is beneficial. We examined the effects of administering TPT or X-radiation (XR) alone at different times of the day or night. Methods: We treated mice bearing human colorectal tumor xenografts at four different times representing the early rest period (9 AM or 3 HALO [hours after light onset]), late rest period (3 PM or 9 HALO), early active period (9 PM or 15 HALO), and late active period (3 AM or 21 HALO) of the mice. We gave either TPT (12 mg/kg, injected i.p.) or XR (4 Gy, directed to the tumor) twice weekly on Days 0, 4, 7, 10 within 2 weeks. Results: Treatment with either TPT or XR at 3 AM demonstrated the greatest efficacy (measured by a tumor regrowth assay) without significantly increasing acute toxicity (assessed by a decrease in leukocyte counts or body weight). Conversely, treatment at 3 PM, in particular, showed increased toxicity without any enhanced efficacy. Conclusions: Our study provided the first evidence that chronomodulation of TPT treatments, consistent with the findings of other camptothecin analogs, is potentially clinically beneficial. Additionally, our findings suggest that chronomodulation of fractionated XR treatments is also potentially clinically beneficial.

  13. Comparative toxicity of pentachlorophenol to three earthworm species in artificial soil

    SciTech Connect (OSTI)

    Fitzgerald, D.; Lanno, R.P.; Farwell, A.; Dixon, D.G.

    1994-12-31

    Although methods for standardized toxicity tests with earthworms exist, many of the test parameters and conditions have not been validated in actual tests and with different species of worms. This study evaluated the toxicity of pentachlorophenol (PCP) to three species of earthworms, Lumbricus terrestris, Eisenia fetida, and Eudrilus eugeniae using various methods of data analysis and body residues. Tests were conducted in artificial soil for a period of 28 days or until an Acute Lethality Threshold (ALT) was reached. An intensive temporal sampling regime was applied to generate sufficient data for the accurate estimation of ALTs using both LC50/time and time-to-death/soil concentration methods of data analysis. L. terrestris was tested at 15 C, E. eugeniae at 24 C, and E. fetida at both temperatures. Total body residues of PCP were measured by GC following cryogenic separation of the lipid fraction of the worm. ALTs were significantly different between E. fetida and the two larger species of worms. No effect of temperature on the ALT for E. fetida was observed, although the time taken to reach the ALT increased at the lower temperature. The relationship of PCP residues at mortality will be discussed in terms of the effects of species, body size and temperature. Limitations of the artificial soil based upon growth curves of worms will also be examined.

  14. Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Harper, Bryan; Thomas, Dennis G.; Chikkagoudar, Satish; Baker, Nathan A.; Tang, Kaizhi; Heredia-Langner, Alejandro; Lins, Roberto D.; Harper, Stacey

    2015-06-04

    The integration of rapid assays, large data sets, informatics and modeling can overcome current barriers in understanding nanomaterial structure-toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated EZ Metric scores, a combined measure of morbidity and mortality, were established at realistic exposure levels and used to develop a predictive model of nanomaterial toxicity. Hazard ranking and clustering analysis of 68 diverse nanomaterials revealed distinct patterns of toxicity related to both core composition and outermost surface chemistrymore » of nanomaterials. The resulting clusters guided the development of a predictive model of gold nanoparticle toxicity to embryonic zebrafish. In addition, our findings suggest that risk assessments based on the size and core composition of nanomaterials alone may be wholly inappropriate, especially when considering complex engineered nanomaterials. These findings reveal the need to expeditiously increase the availability of quantitative measures of nanomaterial hazard and broaden the sharing of that data and knowledge to support predictive modeling. In addition, research should continue to focus on methodologies for developing predictive models of nanomaterial hazard based on sub-lethal responses to low dose exposures.« less

  15. Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity

    SciTech Connect (OSTI)

    Harper, Bryan; Thomas, Dennis G.; Chikkagoudar, Satish; Baker, Nathan A.; Tang, Kaizhi; Heredia-Langner, Alejandro; Lins, Roberto D.; Harper, Stacey

    2015-06-04

    The integration of rapid assays, large data sets, informatics and modeling can overcome current barriers in understanding nanomaterial structure-toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard rankings for nanomaterials. Here we present the use of a rapid, low-cost assay to perform screening-level toxicity evaluations of nanomaterials in vivo. Calculated EZ Metric scores, a combined measure of morbidity and mortality, were established at realistic exposure levels and used to develop a predictive model of nanomaterial toxicity. Hazard ranking and clustering analysis of 68 diverse nanomaterials revealed distinct patterns of toxicity related to both core composition and outermost surface chemistry of nanomaterials. The resulting clusters guided the development of a predictive model of gold nanoparticle toxicity to embryonic zebrafish. In addition, our findings suggest that risk assessments based on the size and core composition of nanomaterials alone may be wholly inappropriate, especially when considering complex engineered nanomaterials. These findings reveal the need to expeditiously increase the availability of quantitative measures of nanomaterial hazard and broaden the sharing of that data and knowledge to support predictive modeling. In addition, research should continue to focus on methodologies for developing predictive models of nanomaterial hazard based on sub-lethal responses to low dose exposures.

  16. Toxicity of polychlorinated diphenyl ethers in hydra attenuata and in rat whole-embryo culture. Master's thesis

    SciTech Connect (OSTI)

    Becker, M.C.

    1991-05-01

    Polychlorinated diphenyl ethers (PCDEs) are a class of biaryl compounds that have little commercial application, but appear to be widespread in the environment. They have been found in wood preservative waste dumpsites and in fly ash from municipal waste incinerators. They have been detected in bird eggs and tissues, fish, and other edible marine organisms in the United States, Canada, and Europe. There are limited reports in the extant literature on the toxicity of PCDEs. This study was designed to evaluate the toxicity of selected PCDEs in cultures of Hydra attenuata and post-implantation rat whole embryos. The toxicity of several closely related polychlorinated biphenyls (PCBs) was evaluated in both cultures and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was evaluated in whole embryo culture. Embryonic growth and development parameters (yolk sac diameter, crown-rump length, somite count, and DNA and protein content) and gross morphology were determined. Findings indicated that these chemicals were neither embryotoxic nor teratogenic. Thus, the PCDEs, which elicit other diverse toxic and biochemical responses in rodents, are relatively inactive in these bioassays for developmental toxicity.

  17. High Efficiency Integrated Package

    SciTech Connect (OSTI)

    Ibbetson, James

    2013-09-15

    Solid-state lighting based on LEDs has emerged as a superior alternative to inefficient conventional lighting, particularly incandescent. LED lighting can lead to 80 percent energy savings; can last 50,000 hours 2-50 times longer than most bulbs; and contains no toxic lead or mercury. However, to enable mass adoption, particularly at the consumer level, the cost of LED luminaires must be reduced by an order of magnitude while achieving superior efficiency, light quality and lifetime. To become viable, energy-efficient replacement solutions must deliver system efficacies of ? 100 lumens per watt (LPW) with excellent color rendering (CRI > 85) at a cost that enables payback cycles of two years or less for commercial applications. This development will enable significant site energy savings as it targets commercial and retail lighting applications that are most sensitive to the lifetime operating costs with their extended operating hours per day. If costs are reduced substantially, dramatic energy savings can be realized by replacing incandescent lighting in the residential market as well. In light of these challenges, Cree proposed to develop a multi-chip integrated LED package with an output of > 1000 lumens of warm white light operating at an efficacy of at least 128 LPW with a CRI > 85. This product will serve as the light engine for replacement lamps and luminaires. At the end of the proposed program, this integrated package was to be used in a proof-of-concept lamp prototype to demonstrate the components viability in a common form factor. During this project Cree SBTC developed an efficient, compact warm-white LED package with an integrated remote color down-converter. Via a combination of intensive optical, electrical, and thermal optimization, a package design was obtained that met nearly all project goals. This package emitted 1295 lm under instant-on, room-temperature testing conditions, with an efficacy of 128.4 lm/W at a color temperature of ~2873K and 83 CRI. As such, the packages performance exceeds DOEs warm-white phosphor LED efficacy target for 2013. At the end of the program, we assembled an A19 sized demonstration bulb housing the integrated package which met Energy Star intensity variation requirements. With further development to reduce overall component cost, we anticipate that an integrated remote converter package such as developed during this program will find application in compact, high-efficacy LED-based lamps, particularly those requiring omnidirectional emission.

  18. Canadian Environmental Protection Act, strategic options for the management of toxic substances: Electric power generation (fossil fuel) sector, report of stakeholder consultations

    SciTech Connect (OSTI)

    1997-12-31

    The Electric Power Generation Sector Issue Table was formed to assess the management of toxic substances released from that sector, and more specifically, to develop (where warranted) goals, targets, and effective and efficient options for managing toxic releases in order to reduce potential risks to human health and the environment. This strategic options report sets out the recommendations of Issue Table members for the management of toxic substances. The introduction includes an industry profile and a review of the provincial management of electric power sector strategic options priority (SOP) substances. Chapter 2 discusses what substances are toxic, estimates releases of SOP substances from the sector, and reviews Issue Table approaches to risk assessment. Chapter 3 outlines Issue Table activities. Chapter 4 screens toxic substance management options, with evaluation of options against 13 groups of criteria. Chapter 5 presents toxic substances management proposals made to the Issue Table by the electric power generation industry, environmental groups, and Environment Canada.

  19. Intensity-Modulated Radiotherapy as Primary Therapy for Prostate Cancer: Report on Acute Toxicity After Dose Escalation With Simultaneous Integrated Boost to Intraprostatic Lesion

    SciTech Connect (OSTI)

    Fonteyne, Valerie Villeirs, Geert; Speleers, Bruno; Neve, Wilfried de; Wagter, Carlos de; Lumen, Nicolas; Meerleer, Gert de

    2008-11-01

    Purpose: To report on the acute toxicity of a third escalation level using intensity-modulated radiotherapy for prostate cancer (PCa) and the acute toxicity resulting from delivery of a simultaneous integrated boost (SIB) to an intraprostatic lesion (IPL) detected on magnetic resonance imaging (MRI), with or without spectroscopy. Methods and Materials: Between January 2002 and March 2007, we treated 230 patients with intensity-modulated radiotherapy to a third escalation level as primary therapy for prostate cancer. If an IPL (defined by MRI or MRI plus spectroscopy) was present, a SIB was delivered to the IPL. To report on acute toxicity, patients were seen weekly during treatment and 1 and 3 months after treatment. Toxicity was scored using the Radiation Therapy Oncology Group toxicity scale, supplemented by an in-house-developed scoring system. Results: The median dose to the planning target volume was 78 Gy. An IPL was found in 118 patients. The median dose to the MRI-detected IPL and MRI plus spectroscopy-detected IPL was 81 Gy and 82 Gy, respectively. No Grade 3 or 4 acute gastrointestinal toxicity developed. Grade 2 acute gastrointestinal toxicity was present in 26 patients (11%). Grade 3 genitourinary toxicity was present in 15 patients (7%), and 95 patients developed Grade 2 acute genitourinary toxicity (41%). No statistically significant increase was found in Grade 2-3 acute gastrointestinal or genitourinary toxicity after a SIB to an IPL. Conclusion: The results of our study have shown that treatment-induced acute toxicity remains low when intensity-modulated radiotherapy to 80 Gy as primary therapy for prostate cancer is used. In addition, a SIB to an IPL did not increase the severity or incidence of acute toxicity.

  20. Toxicity mitigation and solidification of municipal solid waste incinerator fly ash using alkaline activated coal ash

    SciTech Connect (OSTI)

    Ivan Diaz-Loya, E.; Allouche, Erez N.; Eklund, Sven; Joshi, Anupam R.; Kupwade-Patil, Kunal

    2012-08-15

    Highlights: Black-Right-Pointing-Pointer Incinerator fly ash (IFA) is added to an alkali activated coal fly ash (CFA) matrix. Black-Right-Pointing-Pointer Means of stabilizing the incinerator ash for use in construction applications. Black-Right-Pointing-Pointer Concrete made from IFA, CFA and IFA-CFA mixes was chemically characterized. Black-Right-Pointing-Pointer Environmentally friendly solution to IFA disposal by reducing its toxicity levels. - Abstract: Municipal solid waste (MSW) incineration is a common and effective practice to reduce the volume of solid waste in urban areas. However, the byproduct of this process is a fly ash (IFA), which contains large quantities of toxic contaminants. The purpose of this research study was to analyze the chemical, physical and mechanical behaviors resulting from the gradual introduction of IFA to an alkaline activated coal fly ash (CFA) matrix, as a mean of stabilizing the incinerator ash for use in industrial construction applications, where human exposure potential is limited. IFA and CFA were analyzed via X-ray fluorescence (XRF), X-ray diffraction (XRD) and Inductive coupled plasma (ICP) to obtain a full chemical analysis of the samples, its crystallographic characteristics and a detailed count of the eight heavy metals contemplated in US Title 40 of the Code of Federal Regulations (40 CFR). The particle size distribution of IFA and CFA was also recorded. EPA's Toxicity Characteristic Leaching Procedure (TCLP) was followed to monitor the leachability of the contaminants before and after the activation. Also images obtained via Scanning Electron Microscopy (SEM), before and after the activation, are presented. Concrete made from IFA, CFA and IFA-CFA mixes was subjected to a full mechanical characterization; tests include compressive strength, flexural strength, elastic modulus, Poisson's ratio and setting time. The leachable heavy metal contents (except for Se) were below the maximum allowable limits and in many cases even below the reporting limit. The leachable Chromium was reduced from 0.153 down to 0.0045 mg/L, Arsenic from 0.256 down to 0.132 mg/L, Selenium from 1.05 down to 0.29 mg/L, Silver from 0.011 down to .001 mg/L, Barium from 2.06 down to 0.314 mg/L and Mercury from 0.007 down to 0.001 mg/L. Although the leachable Cd exhibited an increase from 0.49 up to 0.805 mg/L and Pd from 0.002 up to 0.029 mg/L, these were well below the maximum limits of 1.00 and 5.00 mg/L, respectively.

  1. Mass-transport models to predict toxicity of inhaled gases in the upper respiratory tract

    SciTech Connect (OSTI)

    Hubal, E.A.C.; Fedkiw, P.S.; Kimbell, J.S. [North Carolina State Univ., Raleigh, NC (United States)

    1996-04-01

    Mass-transport (the movement of a chemical species) plays an important role in determining toxic responses of the upper respiratory tract (URT) to inhaled chemicals. Mathematical dosimetry models incorporate physical characteristics of mass transport and are used to predict quantitative uptake (absorption rate) and distribution of inhaled gases and vapors in the respiratory tract. Because knowledge of dose is an essential component of quantitative risk assessment, dosimetry modeling plays an important role in extrapolation of animal study results to humans. A survey of existing mathematical dosimetry models for the URT is presented, limitations of current models are discussed, and adaptations of existing models to produce a generally applicable model are suggested. Reviewed URT dosimetry models are categorized as early, lumped-parameter, and distributed-parameter models. Specific examples of other relevant modeling work are also presented. 35 refs., 11 figs., 1 tab.

  2. Proton Beam Craniospinal Irradiation Reduces Acute Toxicity for Adults With Medulloblastoma

    SciTech Connect (OSTI)

    Brown, Aaron P.; Barney, Christian L.; Grosshans, David R.; McAleer, Mary Frances; Groot, John F. de; Puduvalli, Vinay K.; Tucker, Susan L.; Crawford, Cody N.; Khan, Meena; Khatua, Soumen; Gilbert, Mark R.; Brown, Paul D.; Mahajan, Anita

    2013-06-01

    Purpose: Efficacy and acute toxicity of proton craniospinal irradiation (p-CSI) were compared with conventional photon CSI (x-CSI) for adults with medulloblastoma. Methods and Materials: Forty adult medulloblastoma patients treated with x-CSI (n=21) or p-CSI (n=19) at the University of Texas MD Anderson Cancer Center from 2003 to 2011 were retrospectively reviewed. Median CSI and total doses were 30.6 and 54 Gy, respectively. The median follow-up was 57 months (range 4-103) for x-CSI patients and 26 months (range 11-63) for p-CSI. Results: p-CSI patients lost less weight than x-CSI patients (1.2% vs 5.8%; P=.004), and less p-CSI patients had >5% weight loss compared with x-CSI (16% vs 64%; P=.004). p-CSI patients experienced less grade 2 nausea and vomiting compared with x-CSI (26% vs 71%; P=.004). Patients treated with x-CSI were more likely to have medical management of esophagitis than p-CSI patients (57% vs 5%, P<.001). p-CSI patients had a smaller reduction in peripheral white blood cells, hemoglobin, and platelets compared with x-CSI (white blood cells 46% vs 55%, P=.04; hemoglobin 88% vs 97%, P=.009; platelets 48% vs 65%, P=.05). Mean vertebral doses were significantly associated with reductions in blood counts. Conclusions: This report is the first analysis of clinical outcomes for adult medulloblastoma patients treated with p-CSI. Patients treated with p-CSI experienced less treatment-related morbidity including fewer acute gastrointestinal and hematologic toxicities.

  3. Intervention of D-glucose ameliorates the toxicity of streptozotocin in accessory sex organs of rat

    SciTech Connect (OSTI)

    Vikram, A.; Tripathi, D.N.; Ramarao, P. [Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, Punjab-160062 (India); Jena, G.B. [Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sector-67, S.A.S. Nagar, Punjab-160062 (India)], E-mail: gbjena@gmail.com

    2008-01-01

    Streptozotocin (STZ) is a naturally occurring compound isolated from Streptomyces achromogens. It is used extensively for inducing diabetes in experimental animals. Diabetes mellitus is known to have proven adverse effects on male sexual organs and their reproductive functions. The atrophy of prostate gland and other organs of the genitourinary tract were observed in experimental diabetic animals. STZ exhibits a structural resemblance to D-glucose due to the presence of sugar moiety in its structure. Pancreatic {beta}-cells mainly contain GLUT1 and GLUT2 glucose transporters. Possibly due to structural resemblance, STZ and D-glucose, share a common recognition site for entry into the {beta}-cells. The objective of the present study is to evaluate the effect of D-glucose on STZ-induced toxicity in accessory sex organs of male rats. Animals were kept on overnight fasting. One group received vehicle and served as negative control, while all other groups were given STZ (45 mg/kg). Animals that received only STZ served as positive control. The effect of D-glucose was studied on STZ treated animals with different dosage of D-glucose (250, 500, 1000 and 2000 mg/kg). Restoration of body weight, plasma glucose and plasma insulin was evident only at 1000 and 2000 mg/kg of D-glucose. The protective effect of D-glucose is evident only when it is administered simultaneously with STZ. In the present investigation, we report that simultaneous administration of D-glucose along with STZ ameliorates STZ-induced toxicity. This is evident from the restoration of accessory sex organ's weight, cellular morphology as well as insulin level.

  4. Toxicity studies on Agents GB and GD (Phase 2): 90-day subchronic study of GB (Sarin, Type I) in CD rats. Final report, Jul 85-Aug 91

    SciTech Connect (OSTI)

    Bucci, T.J.; Parker, R.M.; Crowell, J.A.; Thurman, J.D.; Gosnell, P.A.

    1991-08-01

    A two-phase Dose Range finding study and a 90-Day Subchronic study were conducted in CD rats using the organophosphate ester Sarin (Agent GB, Type I, CAS Number 107-44-8). The highest dose level without lethality in the second phase of the range finding study was designated the maximum tolerated dose (MTD). The doses selected for the subchronic study were the MTD (300 micron GBI/Kg/day), MTD/2 (150, micron GBI/Kg/day), MTD/4 (75 micron GBI/Kg/day), and a vehicle control (O micron /Kg/day). Forty-eight male and forty-eight female CD rats were randomly allocated at 11-12 weeks of age into four treatment groups (12 per sex per group). The animals were gavaged Monday through Friday for 13 weeks and euthanized with carbon dioxide at the beginning of the fourteenth week. Animals were observed daily for clinical signs of toxicity and were weighed weekly. The rats were bled (6 rats/sex/dose) during weeks -1, 1, 3, 7, and at necropsy. Necropsy examination was performed on all animals. Microscopic evaluation was performed on all high-dose and control animals, and on those tissues of lower dose animals that were abnormal at necropsy. All gross lesions and all animals dying or removed early received histological examination. A cause of death or morbidity for animals removed before the end of the study, determined from histopathological examination, was established in four of the eight cases. There were several statistically significant effects in the clinical chemistry and hematology data. These effects were scattered among the treatment groups and were not numerous enough to develop a pattern of organ toxicity.

  5. Building Toxic Metal Characterization and Decontamination Report: Area 6, Building 914

    SciTech Connect (OSTI)

    NSTec Industrial Hygiene

    2011-08-15

    The purpose of this report is to outline the toxic metal characterization and decontamination efforts in Area 6, Building 914. This includes the initial building inspection, the hotspot sampling, results/findings, building cleanup, and the verification sampling. Building 914 is a steel light frame building that was constructed in 1992. It is about 16,454 square feet, and five employees are assigned to this building. According to the building's floor plan blueprints, it could be inferred that this building was once a Wiremen/Lineman shop. In 2002-2004, the National Nuclear Security Administration Nevada Site Office embarked on a broad characterization of beryllium (Be) surface concentrations throughout the North Las Vegas Facility, the Nevada National Security Site (NNSS), and ancillary facilities like the Special Technologies Laboratory, Remote Sensing Laboratory, etc. Building 914 was part of this characterization. The results of the 2002 study illustrated that the metal housekeeping limits were within acceptable limits and from a Be standpoint, the building was determined to be fit for occupancy. On March 2, 2011, based on a request from Building 914 users, National Security Technologies, LLC (NSTec) Industrial Hygiene (IH) collected bulk samples from the southwest corner of Building 914 at heights above 6 feet where black dust had been noticed on this particular wall. IH conducted surface swipe sampling of the area and analyzed the samples for toxic metals, namely, beryllium (Be), cadmium (Cd), chromium (Cr), lead (Pb), and manganese (Mn). The sample results indicated values two to four times above the housekeeping threshold for Be, Cd, Cr, Pb, and Mn. Subsequently, the facility was closed and posted; the necessary personnel were notified; and controls were instituted for ingress and egress of the building. On March 17, 2011, IH performed an extensive sampling event involving the entire warehouse in accordance with NSTec Organization Procedure OP-P250.004, Sampling Procedures. Analysis of the results from this exercise illustrated that toxic metal contamination was ubiquitous throughout the warehouse section of this building but did not extend into the office, restroom, and break room areas. On March 22, 2011, a planning meeting was held with Environment, Safety, Health & Quality management; Operations & Infrastructure (O&I) mangement; Facility Management; Occupational Medicine; O&I Operations; and IH. After a brief discussion concerning the salient facts of the surface sample results, it was agreed that the facility and its contents required cleaning. The facility would then be re-sampled to verify cleanliness and suitability for re-occupancy. On April 18, 2011, warehouse cleanup activites began. On July 5, 2011, upon receipt of the results from the last cleaned section, the cleanup operations were concluded. The building was statistically determined to be clean; thus, it could be reoccupied and the warehouse operations could resume immediately.

  6. Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes

    SciTech Connect (OSTI)

    Doherty, Kimberly R.; Wappel, Robert L.; Talbert, Dominique R.; Trusk, Patricia B.; Moran, Diarmuid M.; Kramer, James W.; Brown, Arthur M.; Shell, Scott A.; Bacus, Sarah

    2013-10-01

    Tyrosine kinase inhibitors (TKi) have greatly improved the treatment and prognosis of multiple cancer types. However, unexpected cardiotoxicity has arisen in a subset of patients treated with these agents that was not wholly predicted by pre-clinical testing, which centers around animal toxicity studies and inhibition of the human Ether--go-go-Related Gene (hERG) channel. Therefore, we sought to determine whether a multi-parameter test panel assessing the effect of drug treatment on cellular, molecular, and electrophysiological endpoints could accurately predict cardiotoxicity. We examined how 4 FDA-approved TKi agents impacted cell viability, apoptosis, reactive oxygen species (ROS) generation, metabolic status, impedance, and ion channel function in human cardiomyocytes. The 3 drugs clinically associated with severe cardiac adverse events (crizotinib, sunitinib, nilotinib) all proved to be cardiotoxic in our in vitro tests while the relatively cardiac-safe drug erlotinib showed only minor changes in cardiac cell health. Crizotinib, an ALK/MET inhibitor, led to increased ROS production, caspase activation, cholesterol accumulation, disruption in cardiac cell beat rate, and blockage of ion channels. The multi-targeted TKi sunitinib showed decreased cardiomyocyte viability, AMPK inhibition, increased lipid accumulation, disrupted beat pattern, and hERG block. Nilotinib, a second generation Bcr-Abl inhibitor, led to increased ROS generation, caspase activation, hERG block, and an arrhythmic beat pattern. Thus, each drug showed a unique toxicity profile that may reflect the multiple mechanisms leading to cardiotoxicity. This study demonstrates that a multi-parameter approach can provide a robust characterization of drug-induced cardiomyocyte damage that can be leveraged to improve drug safety during early phase development. - Highlights: TKi with known adverse effects show unique cardiotoxicity profiles in this panel. Crizotinib increases ROS, apoptosis, and cholesterol as well as alters beat rate. Sunitinib inhibits AMPK, increases lipids and alters the cardiac beat pattern. Nilotinib causes ROS and caspase activation, decreased lipids and arrhythmia. Erlotinib did not impact ROS, caspase, or lipid levels or affect the beat pattern.

  7. Unexpected gender difference in sensitivity to the acute toxicity of dioxin in mice

    SciTech Connect (OSTI)

    Pohjanvirta, Raimo; Miettinen, Hanna; Sankari, Satu; Hegde, Nagabhooshan; Lindn, Jere; Department of Veterinary Biosciences, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 66, FI-00014 University of Helsinki

    2012-07-15

    The acute toxicity of the ubiquitous environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) varies widely among species and strains. Previous studies in rats have established that females are approximately 2-fold more sensitive to TCDD lethality than males. However, there is a surprising gap in the literature regarding possible gender-related sensitivity differences in mice. In the present study, by using three substrains of TCDD-sensitive C57BL/6 mice and transgenic mice on this background, we demonstrated that: 1) in contrast to the situation in rats, female mice are the more resistant gender; 2) the magnitude of the divergence between male and female mice depends on the substrain, but can amount to over 10-fold; 3) AH receptor protein expression levels or mutations in the primary structure of this receptor are not involved in the resistance of female mice of a C57BL/6 substrain, despite their acute LD{sub 50} for TCDD being over 5000 ?g/kg; 4) transgenic mice that globally express the rat wildtype AH receptor follow the mouse type of gender difference; 5) in gonadectomized mice, ovarian estrogens appear to enhance TCDD resistance, whereas testicular androgens seem to augment TCDD susceptibility; and 6) the gender difference correlates best with the severity of liver damage, which is also reflected in hepatic histopathology and the expression of pro-inflammatory cytokines, especially IL-6. Hence, the two closely related rodent species most often employed in toxicological risk characterization studies, rat and mouse, represent opposite examples of the influence of gender on dioxin sensitivity, further complicating the risk assessment of halogenated aromatic hydrocarbons. -- Highlights: ? In contrast to rats, male mice are more sensitive to TCDD toxicity than female mice. ? The resistance of female C57BL/6Kuo mice matches or exceeds that of male DBA/2 mice. ? The resistance of female C57BL/6Kuo mice is not based on AHR structure or abundance. ? Both androgens and estrogens appear to influence TCDD sensitivity. ? TCDD sensitivity correlates best with the severity of lesions in the liver.

  8. Fluoride-elicited developmental testicular toxicity in rats: Roles of endoplasmic reticulum stress and inflammatory response

    SciTech Connect (OSTI)

    Zhang, Shun; Jiang, Chunyang; Liu, Hongliang; Guan, Zhizhong; Zeng, Qiang; Zhang, Cheng; Lei, Rongrong; Xia, Tao; Gao, Hui; Yang, Lu; Chen, Yihu; Wu, Xue; Zhang, Xiaofei; Cui, Yushan; Yu, Linyu; Wang, Zhenglun; Wang, Aiguo

    2013-09-01

    Long-term excessive fluoride intake is known to be toxic and can damage a variety of organs and tissues in the human body. However, the molecular mechanisms underlying fluoride-induced male reproductive toxicity are not well understood. In this study, we used a rat model to simulate the situations of human exposure and aimed to evaluate the roles of endoplasmic reticulum (ER) stress and inflammatory response in fluoride-induced testicular injury. SpragueDawley rats were administered with sodium fluoride (NaF) at 25, 50 and 100 mg/L via drinking water from pre-pregnancy to gestation, birth and finally to post-puberty. And then the testes of male offspring were studied at 8 weeks of age. Our results demonstrated that fluoride treatment increased MDA accumulation, decreased SOD activity, and enhanced germ cell apoptosis. In addition, fluoride elevated mRNA and protein levels of glucose-regulated protein 78 (GRP78), inositol requiring ER-to-nucleus signal kinase 1 (IRE1), and C/EBP homologous protein (CHOP), indicating activation of ER stress signaling. Furthermore, fluoride also induced testicular inflammation, as manifested by gene up-regulation of tumor necrosis factor-? (TNF-?), interleukin-1? (IL-1?), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in a nuclear factor-?B (NF-?B)-dependent manner. These were associated with marked histopathological lesions including injury of spermatogonia, decrease of spermatocytes and absence of elongated spermatids, as well as severe ultrastructural abnormalities in testes. Taken together, our results provide compelling evidence that ER stress and inflammation would be novel and significant mechanisms responsible for fluoride-induced disturbance of spermatogenesis and germ cell loss in addition to oxidative stress. - Highlights: We used a rat model to simulate the situations of human fluoride (F) exposure. Developmental F exposure induces testicular damage related with oxidative stress. Endoplasmic reticulum stress is involved in testis disorder and germ cell apoptosis. Inflammatory response is implicated in impaired spermatogenesis and germ cell loss.

  9. Clinical Application of High-Dose, Image-Guided Intensity-Modulated Radiotherapy in High-Risk Prostate Cancer

    SciTech Connect (OSTI)

    Bayley, Andrew, E-mail: Andrew.Bayley@rmp.uhn.on.c [Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON (Canada) and Department of Radiation Oncology, University of Toronto, Toronto, ON (Canada); Rosewall, Tara; Craig, Tim; Bristow, Rob; Chung, Peter; Gospodarowicz, Mary; Menard, Cynthia; Milosevic, Michael; Warde, Padraig; Catton, Charles [Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON (Canada) and Department of Radiation Oncology, University of Toronto, Toronto, ON (Canada)

    2010-06-01

    Purpose: To report the feasibility and early toxicity of dose-escalated image-guided IMRT to the pelvic lymph nodes (LN), prostate (P), and seminal vesicles (SV). Methods and Materials: A total of 103 high-risk prostate cancer patients received two-phase, dose-escalated, image-guided IMRT with 3 years of androgen deprivation therapy. Clinical target volumes (CTVs) were delineated using computed tomography/magnetic resonance co-registration and included the prostate, portions of the SV, and the LN. Planning target volume margins (PTV) used were as follows: P (10 mm, 7 mm posteriorly), SV (10 mm), and LN (5 mm). Organs at risk (OaR) were the rectal and bladder walls, femoral heads, and large and small bowel. The IMRT was planned with an intended dose of 55.1 Gy in 29 fractions to all CTVs (Phase 1), with P+SV consecutive boost of 24.7 Gy in 13 fractions. Daily online image guidance was performed using bony landmarks and intraprostatic markers. Feasibility criteria included delivery of intended doses in 80% of patients, 95% of CTV displacements incorporated within PTV during Phase 1, and acute toxicity rate comparable to that of lower-dose pelvic techniques. Results: A total of 91 patients (88%) received the total prescription dose. All patients received at least 72 Gy. In Phase 1, 63 patients (61%) received the intended 55.1 Gy, whereas 87% of patients received at least 50 Gy. Dose reductions were caused by small bowel and rectal wall constraints. All CTVs received the planned dose in >95% of treatment fractions. There were no Radiation Therapy Oncology Group acute toxicities greater than Grade 3, although there were five incidences equivalent to Grade 3 within a median follow-up of 23 months. Conclusion: These results suggest that dose escalation to the PLN+P+SV using IMRT is feasible, with acceptable rates of acute toxicity.

  10. Biofiltration control of VOC and air toxic emissions: n-Butane and benzene

    SciTech Connect (OSTI)

    Allen, E.R.

    1996-12-31

    n-Butane and benzene vapors are routinely observed in urban atmospheres. Their presence in urban airsheds is of concern because of their ozone production potential as volatile organic compounds (VOCs) and/or potential toxicity. Also, these saturated hydrocarbons are representative of airborne aliphatic and aromatic compounds. Separate laboratory studies have been conducted on the biological elimination of n-butane (n-C{sub 4}H{sub 10}) and benzene (C{sub 6}H{sub 6}) from airstreams using treated compost biofilters. The removal efficiencies were found to exceed 90% for a conditioned biofilter medium and pollutant low concentrations (< 25 ppm) and zeroth order kinetics at higher concentrations (> 100 ppm), whereas benzene vapor elimination followed zeroth order kinetics at concentrations up to 200 ppm. The maximum n-butane and benzene elimination capacities observed for the compost biofilters and conditions employed were 25 and 70 g pollutant m{sup -3} h{sup -1}, respectively. 13 refs., 6 figs., 2 tabs.

  11. [Toxicity studies of mild gasification products]. [Quarterly report, October 1, 1992--December 31, 1992

    SciTech Connect (OSTI)

    Not Available

    1992-12-31

    Mild gasification of coal is a technology being developed by the United States Department of Energy and private industry with the hope that a cleaner method of coal use can help meet future energy needs. As the technology develops and its commercial use becomes a more viable possibility, efforts are being made to study the safety or possible toxicity of the mild gasification products. DOE and the National Institute for occupational Safety and Health (NIOSH) are cooperating through an interagency agreement to examine some of these products for their genotoxic potential. NIOSH has studied the mutagenicity of several mild gasification product samples using the Ames Salmonella/microsomal assay. As reported earlier PSIS{number_sign}830331 failed to demonstrate genotoxic activity in the Ames assay under all conditions tested. Since the mild gasification products are complex mixtures, interactions between various components are likely to occur. Such interactions between various components of complex mixtures may increase or decrease genotoxic activity in short-term assays like the Ames test. Although all synergistic interactions may not be detailed, the separate analysis of those components in several classes provides a more accurate view of the genotoxicity of each component and better allows for chemical characterization of the possible mutagens in the mixture. NIOSH has performed mutagenicity studies on the subfractions of PSIS{number_sign}830331. The results of those studies are detailed in this report.

  12. Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells

    SciTech Connect (OSTI)

    Dartel, Dorien A.M. van; Pennings, Jeroen L.A.; Schooten, Frederik J. van; Piersma, Aldert H.

    2010-03-15

    The embryonic stem cell test (EST) predicts developmental toxicity based on the inhibition of cardiomyocyte differentiation of embryonic stem cells (ESC). The subjective endpoint, the long culture duration together with the undefined applicability domain and related predictivity need further improvement to facilitate implementation of the EST into regulatory strategies. These aspects may be improved by studying gene expression changes in the ESC differentiation cultures and their modulation by compound exposure using transcriptomics. Here, we tested the developmental toxicants monobutyl phthalate and 6-aminonicotinamide. ESC were allowed to differentiated, and cardiomyocyte differentiation was assessed after 10 days of culture. RNA of solvent controls was collected after 0, 24, 48, 72 and 96 h of exposure, and RNA of developmental-toxicant-exposed cultures was collected after 24 and 96 h. Samples were hybridized to DNA microarrays, and 1355 genes were found differentially expressed among the unexposed experimental groups. These regulated genes were involved in differentiation-related processes, and Principal Component Analysis (PCA) based on these genes showed that the unexposed experimental groups appeared in chronological order in the PCA, which can therefore be regarded as a continuous representation of the differentiation track. The developmental-toxicant-exposed cultures appeared to deviate significantly from this differentiation track, which confirms the compound-modulating effects on the differentiation process. The incorporation of transcriptomics in the EST is expected to provide a more informative and improved endpoint in the EST as compared with morphology, allowing early detection of differentiation modulation. Furthermore, this approach may improve the definition of the applicability domain and predictivity of the EST.

  13. EVALUATION OF BEST AVAILABLE CONTROL TECHNOLOGY FOR TOXICS (TBACT) DOUBLE SHELL TANK FARMS PRIMARY VENTILATION SYSTEM SUPPORTING WASTE TRANSFER OPERATIONS

    SciTech Connect (OSTI)

    KELLY SE; HAASS CC; KOVACH JL; TURNER DA

    2010-06-03

    This report is an evaluation of Best Available Control Technology for Toxics (tBACT) for installation and operation of the Hanford double shell (DST) tank primary ventilation systems. The DST primary ventilation systems are being modified to support Hanford's waste retrieval, mixing, and delivery of single shell tank (SST) and DST waste throught the DST storage system to the Waste Treatment and Immobilization Plant (WTP).

  14. EVALUATION OF BEST AVAILABLE CONTROL TECHNOLOGY FOR TOXICS -TBACT- DOUBLE SHELL TANK FARMS PRIMARY VENTILATION SYSTEMS SUPPORTING WASTE TRANSFER OPERATIONS

    SciTech Connect (OSTI)

    HAAS CC; KOVACH JL; KELLY SE; TURNER DA

    2010-06-24

    This report is an evaluation of Best Available Control Technology for Toxics (tBACT) for installation and operation of the Hanford double shell (DST) tank primary ventilation systems. The DST primary ventilation systems are being modified to support Hanford's waste retrieval, mixing, and delivery of single shell tank (SST) and DST waste through the DST storage system to the Waste Treatment and Immobilizaiton Plant (WTP).

  15. VirtualToxLab A platform for estimating the toxic potential of drugs, chemicals and natural products

    SciTech Connect (OSTI)

    Vedani, Angelo; Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel ; Dobler, Max; Smieko, Martin

    2012-06-01

    The VirtualToxLab is an in silico technology for estimating the toxic potential (endocrine and metabolic disruption, some aspects of carcinogenicity and cardiotoxicity) of drugs, chemicals and natural products. The technology is based on an automated protocol that simulates and quantifies the binding of small molecules towards a series of proteins, known or suspected to trigger adverse effects. The toxic potential, a non-linear function ranging from 0.0 (none) to 1.0 (extreme), is derived from the individual binding affinities of a compound towards currently 16 target proteins: 10 nuclear receptors (androgen, estrogen ?, estrogen ?, glucocorticoid, liver X, mineralocorticoid, peroxisome proliferator-activated receptor ?, progesterone, thyroid ?, and thyroid ?), four members of the cytochrome P450 enzyme family (1A2, 2C9, 2D6, and 3A4), a cytosolic transcription factor (aryl hydrocarbon receptor) and a potassium ion channel (hERG). The interface to the technology allows building and uploading molecular structures, viewing and downloading results and, most importantly, rationalizing any prediction at the atomic level by interactively analyzing the binding mode of a compound with its target protein(s) in real-time 3D. The VirtualToxLab has been used to predict the toxic potential for over 2500 compounds: the results are posted on (http://www.virtualtoxlab.org). The free platform the OpenVirtualToxLab is accessible (in clientserver mode) over the Internet. It is free of charge for universities, governmental agencies, regulatory bodies and non-profit organizations. -- Highlights: ? In silico technology for estimating the toxic potential of drugs and chemicals. ? Simulation of binding towards 16 proteins suspected to trigger adverse effects. ? Mechanistic interpretation and real-time 3D visualization. ? Accessible over the Internet. ? Free of charge for universities, governmental agencies, regulatory bodies and NPOs.

  16. Environmental characterization studies of a high-throughput wood gasifier

    SciTech Connect (OSTI)

    Chang, H.; Niemann, R.C.; Wilzbach, K.E.; Paisley, M.

    1983-01-01

    Potential environmental effects associated with thermochemical biomass gasification have been studied by Argonne National Laboratory in cooperation with Battelle Columbus Laboratories (BCL). A series of samples from the process research unit of an indirectly heated, high-throughput wood gasifier operated by BCL has been analyzed for potentially toxic organic compounds and trace elements. The results indicate that, under the test-run conditions, the gasification of both pine and hardwood is accompanied by the formation of some oil, the heavier fraction of which gives a positive response in the Ames assay for mutagenicity and contains numerous phenols and polycyclic aromatic hydrocarbons, including some carcinogens. The implications of these observations are discussed.

  17. Dosimetric Predictors of Duodenal Toxicity After Intensity Modulated Radiation Therapy for Treatment of the Para-aortic Nodes in Gynecologic Cancer

    SciTech Connect (OSTI)

    Verma, Jonathan [Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida (United States); Sulman, Erik P.; Jhingran, Anuja [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Tucker, Susan L. [Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Rauch, Gaiane M. [Department of Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Eifel, Patricia J. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Klopp, Ann H., E-mail: aklopp@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)

    2014-02-01

    Purpose: To determine the incidence of duodenal toxicity in patients receiving intensity modulated radiation therapy (IMRT) for treatment of para-aortic nodes and to identify dosimetric parameters predictive of late duodenal toxicity. Methods and Materials: We identified 105 eligible patients with gynecologic malignancies who were treated with IMRT for gross metastatic disease in the para-aortic nodes from January 1, 2005, through December 31, 2009. Patients were treated to a nodal clinical target volume to 45 to 50.4 Gy with a boost to 60 to 66 Gy. The duodenum was contoured, and dosimetric data were exported for analysis. Duodenal toxicity was scored according to Radiation Therapy Oncology Group criteria. Univariate Cox proportional hazards analysis and recursive partitioning analysis were used to determine associations between dosimetric variables and time to toxicity and to identify the optimal threshold that separated patients according to risk of toxicity. Results: Nine of the 105 patients experienced grade 2 to grade 5 duodenal toxicity, confirmed by endoscopy in all cases. The 3-year actuarial rate of any duodenal toxicity was 11.7%. A larger volume of the duodenum receiving 55 Gy (V55) was associated with higher rates of duodenal toxicity. The 3-year actuarial rates of duodenal toxicity with V55 above and below 15 cm{sup 3} were 48.6% and 7.4%, respectively (P<.01). In Cox univariate analysis of dosimetric variables, V55 was associated with duodenal toxicity (P=.029). In recursive partitioning analysis, V55 less than 13.94% segregated all patients with duodenal toxicity. Conclusions: Dose-escalated IMRT can safely and effectively treat para-aortic nodal disease in gynecologic malignancies, provided that care is taken to limit the dose to the duodenum to reduce the risk of late duodenal toxicity. Limiting V55 to below 15 cm{sup 3} may reduce the risk of duodenal complications. In cases where the treatment cannot be delivered within these constraints, consideration should be given to other treatment approaches such as resection or initial chemotherapy.

  18. Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity

    SciTech Connect (OSTI)

    Brenner, Matthew; Kim, Jae G.; Lee, Jangwoen; Mahon, Sari B.; Lemor, Daniel; Ahdout, Rebecca; Boss, Gerry R.; Blackledge, William; Jann, Lauren; Nagasawa, Herbert T.; Patterson, Steven E.

    2010-11-01

    The aim of this study is to investigate the ability of intramuscular and intravenous sulfanegen sodium treatment to reverse cyanide effects in a rabbit model as a potential treatment for mass casualty resulting from cyanide exposure. Cyanide poisoning is a serious chemical threat from accidental or intentional exposures. Current cyanide exposure treatments, including direct binding agents, methemoglobin donors, and sulfur donors, have several limitations. Non-rhodanese mediated sulfur transferase pathways, including 3-mercaptopyruvate sulfurtransferase (3-MPST) catalyze the transfer of sulfur from 3-MP to cyanide, forming pyruvate and less toxic thiocyanate. We developed a water-soluble 3-MP prodrug, 3-mercaptopyruvatedithiane (sulfanegen sodium), with the potential to provide a continuous supply of substrate for CN detoxification. In addition to developing a mass casualty cyanide reversal agent, methods are needed to rapidly and reliably diagnose and monitor cyanide poisoning and reversal. We use non-invasive technology, diffuse optical spectroscopy (DOS) and continuous wave near infrared spectroscopy (CWNIRS) to monitor physiologic changes associated with cyanide exposure and reversal. A total of 35 animals were studied. Sulfanegen sodium was shown to reverse the effects of cyanide exposure on oxyhemoglobin and deoxyhemoglobin rapidly, significantly faster than control animals when administered by intravenous or intramuscular routes. RBC cyanide levels also returned to normal faster following both intramuscular and intravenous sulfanegen sodium treatment than controls. These studies demonstrate the clinical potential for the novel approach of supplying substrate for non-rhodanese mediated sulfur transferase pathways for cyanide detoxification. DOS and CWNIRS demonstrated their usefulness in optimizing the dose of sulfanegen sodium treatment.

  19. Protective effects and mechanisms of curcumin on podophyllotoxin toxicity in vitro and in vivo

    SciTech Connect (OSTI)

    Li, Juan; Dai, Cai-Xia; Sun, Hua; Jin, Lu; State Key Laboratory of New Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 ; Guo, Chong-Yi; Cao, Wei; Wu, Jie; Tian, Hai-Yan; Luo, Cheng; Ye, Wen-Cai; Jiang, Ren-Wang

    2012-12-01

    Podophyllotoxin (POD) is a naturally occurring lignan with pronounced antineoplastic and antiviral properties. POD binds to tubulin and prevents the formation of mitotic spindle. Although cases of overdose or accidental ingestion are quite often, no specific therapy is currently available to treat the POD intoxication. In the current investigation, the protective effects and mechanisms of curcumin (CUR) on podophyllotoxin toxicity were evaluated in vitro and in vivo. The results showed that CUR could protect POD-induced cytotoxicity by recovering the G2/M arrest and decrease the changes of membrane potential and microtubule structure in Vero cells. A significant decrease of mortality rates was observed in Swiss mice treated by intragastrical administration of POD + CUR as compared with POD alone. The POD + CUR group also exhibited decreases in plasma transaminases, alkaline phosphatase, lactate dehydrogenase, plasma urea, creatinine and malondialdehyde level but elevated superoxide dismutase and glutathione levels as compared to the POD group. Histological examination of the liver and kidney demonstrated less morphological changes in the treatment of POD + CUR as compared with POD alone. The mechanism of the protective effects might be due to the competitive binding of CUR with POD in the same colchicines binding site as revealed by the tubulin polymerization assay and the molecular docking analysis, and the antioxidant activity against the oxidative stress induced by POD. In summary, both in vitro and in vivo data indicated the promising role of CUR as a protective agent against the POD poisoning. Highlights: ? A potential antidote to treat the podophyllotoxin (POD) intoxication is found. ? Curcumin showed promising effects against POD poisoning in vitro and in vivo. ? The mechanisms lie in the antioxidant activity and competitive binding with tubulin.

  20. Reference manual for toxicity and exposure assessment and risk characterization. CERCLA Baseline Risk Assessment

    SciTech Connect (OSTI)

    1995-03-01

    The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA, 1980) (CERCLA or Superfund) was enacted to provide a program for identifying and responding to releases of hazardous substances into the environment. The Superfund Amendments and Reauthorization Act (SARA, 1986) was enacted to strengthen CERCLA by requiring that site clean-ups be permanent, and that they use treatments that significantly reduce the volume, toxicity, or mobility of hazardous pollutants. The National Oil and Hazardous Substances Pollution Contingency Plan (NCP) (USEPA, 1985; USEPA, 1990) implements the CERCLA statute, presenting a process for (1) identifying and prioritizing sites requiring remediation and (2) assessing the extent of remedial action required at each site. The process includes performing two studies: a Remedial Investigation (RI) to evaluate the nature, extent, and expected consequences of site contamination, and a Feasibility Study (FS) to select an appropriate remedial alternative adequate to reduce such risks to acceptable levels. An integral part of the RI is the evaluation of human health risks posed by hazardous substance releases. This risk evaluation serves a number of purposes within the overall context of the RI/FS process, the most essential of which is to provide an understanding of ``baseline`` risks posed by a given site. Baseline risks are those risks that would exist if no remediation or institutional controls are applied at a site. This document was written to (1) guide risk assessors through the process of interpreting EPA BRA policy and (2) help risk assessors to discuss EPA policy with regulators, decision makers, and stakeholders as it relates to conditions at a particular DOE site.

  1. FINE PARTICAL AND TOXIC METAL EMISSIONS FROM THE COMBUSTION OF SEWAGE SLUDGE/COAL MIXTURES: A SYSTEMATIC ASSESSMENT

    SciTech Connect (OSTI)

    Jost O.L. Wendt; Wayne S. Seames; Art Fernandez

    2003-09-21

    This research project focuses on pollutants from the combustion of mixtures of dried municipal sewage sludge (MSS) and pulverized coal. The objective was to determine potential tradeoffs between CO{sub 2} mitigation through using a CO{sub 2} neutral fuel, such as municipal sewage sludge, and the emergence of other potential problems such as the emission of toxic fly ash particles. The work led to new insight into mechanisms governing the partitioning of major and trace metals from the combustion of sewage sludge, and mixtures of coal and sewage sludge. The research also showed that the co-combustion of coal and sewage sludge emitted fine particulate matter that might potentially cause greater lung injury than that from the combustion of either coal alone or municipal sewage sludge alone. The reason appeared to be that the toxicity measured required the presence of large amounts of both zinc and sulfur in particles that were inhaled. MSS provided the zinc while coal provided the sulfur. Additional research showed that the toxic effects could most likely be engineered out of the process, through the introduction of kaolinite sorbent downstream of the combustion zone, or removing the sulfur from the fuel. These results are consequences of applying ''Health Effects Engineering'' to this issue. Health Effects Engineering is a new discipline arising out of this work, and is derived from using a collaboration of combustion engineers and toxicologists to mitigate the potentially bad health effects from combustion of this biomass fuel.

  2. High Energy Physics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High Energy Physics science-innovationassetsimagesicon-science.jpg High Energy Physics Investigating the field of high energy physics through experiments that strengthen our ...

  3. Extended (5-year) Outcomes of Accelerated Partial Breast Irradiation Using MammoSite Balloon Brachytherapy: Patterns of Failure, Patient Selection, and Dosimetric Correlates for Late Toxicity

    SciTech Connect (OSTI)

    Vargo, John A.; Verma, Vivek; Kim, Hayeon; Kalash, Ronny; Heron, Dwight E.; Johnson, Ronald; Beriwal, Sushil

    2014-02-01

    Purpose: Accelerated partial breast irradiation (APBI) with balloon and catheter-based brachytherapy has gained increasing popularity in recent years and is the subject of ongoing phase III trials. Initial data suggest promising local control and cosmetic results in appropriately selected patients. Long-term data continue to evolve but are limited outside of the context of the American Society of Breast Surgeons Registry Trial. Methods and Materials: A retrospective review of 157 patients completing APBI after breast-conserving surgery and axillary staging via high-dose-rate {sup 192}Ir brachytherapy from June 2002 to December 2007 was made. APBI was delivered with a single-lumen MammoSite balloon-based applicator to a median dose of 34 Gy in 10 fractions over a 5-day period. Tumor coverage and critical organ dosimetry were retrospectively collected on the basis of computed tomography completed for conformance and symmetry. Results: At a median follow-up time of 5.5 years (range, 0-10.0 years), the 5-year and 7-year actuarial incidences of ipsilateral breast control were 98%/98%, of nodal control 99%/98%, and of distant control 99%/99%, respectively. The crude rate of ipsilateral breast recurrence was 2.5% (n=4); of nodal failure, 1.9% (n=3); and of distant failure, 0.6% (n=1). The 5-year and 7-year actuarial overall survival rates were 89%/86%, with breast cancerspecific survival of 100%/99%, respectively. Good to excellent cosmetic outcomes were achieved in 93.4% of patients. Telangiectasia developed in 27% of patients, with 1-year, 3-year, and 5-year actuarial incidence of 7%/24%/33%; skin dose >100% significantly predicted for the development of telangiectasia (50% vs 14%, P<.0001). Conclusions: Long-term single-institution outcomes suggest excellent tumor control, breast cosmesis, and minimal late toxicity. Skin toxicity is a function of skin dose, which may be ameliorated with dosimetric optimization afforded by newer multicatheter brachytherapy applicators and a more rigorous skin dose constraint of ?100%.

  4. Mercury and Air Toxic Element Impacts of Coal Combustion By-Product Disposal and Utilizaton

    SciTech Connect (OSTI)

    David Hassett; Loreal Heebink; Debra Pflughoeft-Hassett; Tera Buckley; Erick Zacher; Mei Xin; Mae Sexauer Gustin; Rob Jung

    2007-03-31

    The University of North Dakota Energy & Environmental Research Center (EERC) conducted a multiyear study to evaluate the impact of mercury and other air toxic elements (ATEs) on the management of coal combustion by-products (CCBs). The ATEs evaluated in this project were arsenic, cadmium, chromium, lead, nickel, and selenium. The study included laboratory tasks to develop measurement techniques for mercury and ATE releases, sample characterization, and release experiments. A field task was also performed to measure mercury releases at a field site. Samples of fly ash and flue gas desulfurization (FGD) materials were collected preferentially from full-scale coal-fired power plants operating both without and with mercury control technologies in place. In some cases, samples from pilot- and bench-scale emission control tests were included in the laboratory studies. Several sets of 'paired' baseline and test fly ash and FGD materials collected during full-scale mercury emission control tests were also included in laboratory evaluations. Samples from mercury emission control tests all contained activated carbon (AC) and some also incorporated a sorbent-enhancing agent (EA). Laboratory release experiments focused on measuring releases of mercury under conditions designed to simulate CCB exposure to water, ambient-temperature air, elevated temperatures, and microbes in both wet and dry conditions. Results of laboratory evaluations indicated that: (1) Mercury and sometimes selenium are collected with AC used for mercury emission control and, therefore, present at higher concentrations than samples collected without mercury emission controls present. (2) Mercury is stable on CCBs collected from systems both without and with mercury emission controls present under most conditions tested, with the exception of vapor-phase releases of mercury exposed to elevated temperatures. (3) The presence of carbon either from added AC or from unburned coal can result in mercury being sorbed onto the CCB when exposed to ambient-temperature air. The environmental performance of the mercury captured on AC used as a sorbent for mercury emission control technologies indicated that current CCB management options will continue to be sufficiently protective of the environment, with the potential exception of exposure to elevated temperatures. The environmental performance of the other ATEs investigated indicated that current management options will be appropriate to the CCBs produced using AC in mercury emission controls.

  5. High-Temperature-High-Volume Lifting for Enhanced Geothermal...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-Temperature-High-Volume Lifting for Enhanced Geothermal Systems High-Temperature-High-Volume Lifting for Enhanced Geothermal Systems High-Temperature-High-Volume Lifting for ...

  6. Removal potential of toxic 2378-substituted PCDD/F from incinerator flue gases by waste-derived activated carbons

    SciTech Connect (OSTI)

    Hajizadeh, Yaghoub; Onwudili, Jude A.; Williams, Paul T.

    2011-06-15

    The application of activated carbons has become a commonly used emission control protocol for the removal or adsorption of persistent organic pollutants from the flue gas streams of waste incinerators. In this study, the 2378-substituted PCDD/F removal efficiency of three types of activated carbons derived from the pyrolysis of refuse derived fuel, textile waste and scrap tyre was investigated and compared with that of a commercial carbon. Experiments were carried out in a laboratory scale fixed-bed reactor under a simulated flue gas at 275 deg. C with a reaction period of four days. The PCDD/F in the solid matrices and exhaust gas, were analyzed using gas chromatography coupled with a triple quadrupole mass spectrometer. In the absence of activated carbon adsorbent, there was a significant increase in the concentration of toxic PCDD/F produced in the reacted flyash, reaching up to 6.6 times higher than in the raw flyash. In addition, there was a substantial release of PCDD/F into the gas phase, which was found in the flue gas trapping system. By application of the different commercial, refuse derived fuel, textile and tyre activated carbons the total PCDD/F toxic equivalent removal efficiencies in the exhaust gas stream were 58%, 57%, 64% and 52%, respectively. In general, the removal of the PCDDs was much higher with an average of 85% compared to PCDFs at 41%. Analysis of the reacted activated carbons showed that there was some formation of PCDD/F, for instance, a total of 60.6 {mu}g I-TEQ kg{sup -1} toxic PCDD/F was formed in the refuse derived fuel activated carbon compared to 34 {mu}g I-TEQ kg{sup -1} in the commercial activated carbon. The activated carbons derived from the pyrolysis of waste, therefore, showed good potential as a control material for PCDD/F emissions in waste incinerator flue gases.

  7. A Phase 2 Trial of Once-Weekly Hypofractionated Breast Irradiation: First Report of Acute Toxicity, Feasibility, and Patient Satisfaction

    SciTech Connect (OSTI)

    Dragun, Anthony E.; Quillo, Amy R.; Riley, Elizabeth C.; Roberts, Teresa L.; Hunter, Allison M.; Rai, Shesh N.; Callender, Glenda G.; Jain, Dharamvir; McMasters, Kelly M.; Spanos, William J.

    2013-03-01

    Purpose: To report on early results of a single-institution phase 2 trial of a 5-fraction, once-weekly radiation therapy regimen for patients undergoing breast-conserving surgery (BCS). Methods and Materials: Patients who underwent BCS for American Joint Committee on Cancer stage 0, I, or II breast cancer with negative surgical margins were eligible to receive whole breast radiation therapy to a dose of 30 Gy in 5 weekly fractions of 6 Gy with or without an additional boost. Elective nodal irradiation was not permitted. There were no restrictions on breast size or the use of cytotoxic chemotherapy for otherwise eligible patients. Patients were assessed at baseline, treatment completion, and at first posttreatment follow-up to assess acute toxicity (Common Terminology Criteria for Adverse Events, version 3.0) and quality of life (European Organization for Research and Treatment of Cancer QLQ-BR23). Results: Between January and September 2011, 42 eligible patients underwent weekly hypofractionated breast irradiation immediately following BCS (69.0%) or at the conclusion of cytotoxic chemotherapy (31.0%). The rates of grade ?2 radiation-induced dermatitis, pain, fatigue, and breast edema were 19.0%, 11.9%, 9.5%, and 2.4%, respectively. Only 1 grade 3 toxicitypain requiring a course of narcotic analgesicswas observed. One patient developed a superficial cellulitis (grade 2), which resolved with the use of oral antibiotics. Patient-reported moderate-to-major breast symptoms (pain, swelling, and skin problems), all decreased from baseline through 1 month, whereas breast sensitivity remained stable over the study period. Conclusions: The tolerance of weekly hypofractionated breast irradiation compares well with recent reports of daily hypofractionated whole-breast irradiation schedules. The regimen appears feasible and cost-effective. Additional follow-up with continued accrual is needed to assess late toxicity, cosmesis, and disease-specific outcomes.

  8. Arsenic toxicity induced endothelial dysfunction and dementia: Pharmacological interdiction by histone deacetylase and inducible nitric oxide synthase inhibitors

    SciTech Connect (OSTI)

    Sharma, Bhupesh Sharma, P.M.

    2013-11-15

    Arsenic toxicity has been reported to damage all the major organs including the brain and vasculature. Dementia including Alzheimer's disease (AD) and vascular dementia (VaD) are posing greater risk to the world population as it is now increasing at a faster rate. We have investigated the role of sodium butyrate, a selective histone deacetylase (HDAC) inhibitor and aminoguanidine, a selective inducible nitric oxide synthase (iNOS) inhibitor in pharmacological interdiction of arsenic toxicity induced vascular endothelial dysfunction and dementia in rats. Arsenic toxicity was done by administering arsenic drinking water to rats. Morris water-maze (MWM) test was used for assessment of learning and memory. Endothelial function was assessed using student physiograph. Oxidative stress (aortic superoxide anion, serum and brain thiobarbituric acid reactive species, brain glutathione) and nitric oxide levels (serum nitrite/nitrate) were also measured. Arsenic treated rats have shown impairment of endothelial function, learning and memory, reduction in serum nitrite/nitrate and brain GSH levels along with increase in serum and brain TBARS. Sodium butyrate as well as aminoguanidine significantly convalesce arsenic induced impairment of learning, memory, endothelial function, and alterations in various biochemical parameters. It may be concluded that arsenic induces endothelial dysfunction and dementia, whereas, sodium butyrate, a HDAC inhibitor as well as aminoguanidine, a selective iNOS inhibitor may be considered as potential agents for the management of arsenic induced endothelial dysfunction and dementia. - Highlights: • As has induced endothelial dysfunction (Edf) and vascular dementia (VaD). • As has increased oxidative stress, AChE activity and decreased serum NO. • Inhibitors of HDAC and iNOS have attenuated As induced Edf and VaD. • Both the inhibitors have attenuated As induced biochemical changes. • Inhibitor of HDAC and iNOS has shown good potential in As induced VaD.

  9. High efficiency and high concentration in photovoltaics

    SciTech Connect (OSTI)

    Yamaguchi, Masafumi; Luque, A.

    1999-10-01

    In this paper, the authors present the state-of-the-art of multijunction solar cells and the future prospects of this technology. Their use in terrestrial applications will likely be for concentrators operating at very high concentrations. Some trends are also discussed and the authors present a cost calculation showing that highly efficient cells under very high concentration would be able to produce electricity at costs competitive with electricity generation costs for some utilities.

  10. Separation of toxic metal ions, hydrophilic hydrocarbons, hydrophobic fuel and halogenated hydrocarbons and recovery of ethanol from a process stream

    DOE Patents [OSTI]

    Kansa, Edward J. (Livermore, CA); Anderson, Brian L. (Lodi, CA); Wijesinghe, Ananda M. (Tracy, CA); Viani, Brian E. (Oakland, CA)

    1999-01-01

    This invention provides a process to tremendously reduce the bulk volume of contaminants obtained from an effluent stream produced subsurface remediation. The chemicals used for the subsurface remediation are reclaimed for recycling to the remediation process. Additional reductions in contaminant bulk volume are achieved by the ultra-violet light destruction of halogenated hydrocarbons, and the complete oxidation of hydrophobic fuel hydrocarbons and hydrophilic hydrocarbons. The contaminated bulk volume will arise primarily from the disposal of the toxic metal ions. The entire process is modular, so if there are any technological breakthroughs in one or more of the component process modules, such modules can be readily replaced.

  11. Separation of toxic metal ions, hydrophilic hydrocarbons, hydrophobic fuel and halogenated hydrocarbons and recovery of ethanol from a process stream

    DOE Patents [OSTI]

    Kansa, E.J.; Anderson, B.L.; Wijesinghe, A.M.; Viani, B.E.

    1999-05-25

    This invention provides a process to tremendously reduce the bulk volume of contaminants obtained from an effluent stream produced subsurface remediation. The chemicals used for the subsurface remediation are reclaimed for recycling to the remediation process. Additional reductions in contaminant bulk volume are achieved by the ultra-violet light destruction of halogenated hydrocarbons, and the complete oxidation of hydrophobic fuel hydrocarbons and hydrophilic hydrocarbons. The contaminated bulk volume will arise primarily from the disposal of the toxic metal ions. The entire process is modular, so if there are any technological breakthroughs in one or more of the component process modules, such modules can be readily replaced. 3 figs.

  12. A Novel Method for Predicting Late Genitourinary Toxicity After Prostate Radiation Therapy and the Need for Age-Based Risk-Adapted Dose Constraints

    SciTech Connect (OSTI)

    Ahmed, Awad A.; Egleston, Brian; Alcantara, Pino; Li, Linna; Pollack, Alan; Horwitz, Eric M.; Buyyounouski, Mark K.

    2013-07-15

    Background: There are no well-established normal tissue sparing dosevolume histogram (DVH) criteria that limit the risk of urinary toxicity from prostate radiation therapy (RT). The aim of this study was to determine which criteria predict late toxicity among various DVH parameters when contouring the entire solid bladder and its contents versus the bladder wall. The area under the histogram curve (AUHC) was also analyzed. Methods and Materials: From 1993 to 2000, 503 men with prostate cancer received 3-dimensional conformal RT (median follow-up time, 71 months). The whole bladder and the bladder wall were contoured in all patients. The primary endpoint was grade ?2 genitourinary (GU) toxicity occurring ?3 months after completion of RT. Cox regressions of time to grade ?2 toxicity were estimated separately for the entire bladder and bladder wall. Concordance probability estimates (CPE) assessed model discriminative ability. Before training the models, an external random test group of 100 men was set aside for testing. Separate analyses were performed based on the mean age (? 68 vs >68 years). Results: Age, pretreatment urinary symptoms, mean dose (entire bladder and bladder wall), and AUHC (entire bladder and bladder wall) were significant (P<.05) in multivariable analysis. Overall, bladder wall CPE values were higher than solid bladder values. The AUHC for bladder wall provided the greatest discrimination for late bladder toxicity when compared with alternative DVH points, with CPE values of 0.68 for age ?68 years and 0.81 for age >68 years. Conclusion: The AUHC method based on bladder wall volumes was superior for predicting late GU toxicity. Age >68 years was associated with late grade ?2 GU toxicity, which suggests that risk-adapted dose constraints based on age should be explored.

  13. Critical dose and toxicity index of organs at risk in radiotherapy: Analyzing the calculated effects of modified dose fractionation in nonsmall cell lung cancer

    SciTech Connect (OSTI)

    Pedicini, Piernicola; Strigari, Lidia; Benassi, Marcello; Caivano, Rocchina; Fiorentino, Alba; Nappi, Antonio; Salvatore, Marco; Storto, Giovanni

    2014-04-01

    To increase the efficacy of radiotherapy for nonsmall cell lung cancer (NSCLC), many schemes of dose fractionation were assessed by a new toxicity index (I), which allows one to choose the fractionation schedules that produce less toxic treatments. Thirty-two patients affected by non resectable NSCLC were treated by standard 3-dimensional conformal radiotherapy (3DCRT) with a strategy of limited treated volume. Computed tomography datasets were employed to re plan by simultaneous integrated boost intensity-modulated radiotherapy (IMRT). The dose distributions from plans were used to test various schemes of dose fractionation, in 3DCRT as well as in IMRT, by transforming the dose-volume histogram (DVH) into a biological equivalent DVH (BDVH) and by varying the overall treatment time. The BDVHs were obtained through the toxicity index, which was defined for each of the organs at risk (OAR) by a linear quadratic model keeping an equivalent radiobiological effect on the target volume. The less toxic fractionation consisted in a severe/moderate hyper fractionation for the volume including the primary tumor and lymph nodes, followed by a hypofractionation for the reduced volume of the primary tumor. The 3DCRT and IMRT resulted, respectively, in 4.7% and 4.3% of dose sparing for the spinal cord, without significant changes for the combined-lungs toxicity (p < 0.001). Schedules with reduced overall treatment time (accelerated fractionations) led to a 12.5% dose sparing for the spinal cord (7.5% in IMRT), 8.3% dose sparing for V{sub 20} in the combined lungs (5.5% in IMRT), and also significant dose sparing for all the other OARs (p < 0.001). The toxicity index allows to choose fractionation schedules with reduced toxicity for all the OARs and equivalent radiobiological effect for the tumor in 3DCRT, as well as in IMRT, treatments of NSCLC.

  14. Exploration And Discovery In Yellowstone Lake- Results From High...

    Open Energy Info (EERE)

    and sublacustrine landslides constitute potentially significant geologic hazards. Toxic elements derived from hydrothermal processes also may significantly affect the...

  15. High Performance Computing

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HPC INL Logo Home High-Performance Computing INL's high-performance computing center provides general use scientific computing capabilities to support the lab's efforts in advanced...

  16. Guidelines for Transportation, Handling, and Use of Fast Pyrolysis Bio-Oil. Part 1. Flammability and Toxicity

    SciTech Connect (OSTI)

    Oasmaa, Anja; Kalli, Anssi; Lindfors, Christian; Elliott, Douglas C.; Springer, David L.; Peacocke, Cordner; Chiaramonti, David

    2012-05-04

    An alternative sustainable fuel, biomass-derived fast pyrolysis oil or 'bio-oil', is coming into the market. Fast pyrolysis pilot and demonstration plants for fuel applications producing tonnes of bio-oil are in operation, and commercial plants are under design. There will be increasingly larger amounts of bio-oil transportation on water and by land, leading to a need for specifications and supporting documentation. Bio-oil is different from conventional liquid fuels, and therefore must overcome both technical and marketing hurdles for its acceptability in the fuels market. A comprehensive Material Safety Data Sheet (MSDS) is required, backed with independent testing and certification. In order to standardise bio-oil quality specifications are needed. The first bio-oil burner fuel standard in ASTM (D7544) was approved in 2009. CEN standardisation has been initiated in Europe. In the EU a new chemical regulation system, REACH (Registration, Evaluation and Authorisation of Chemicals) is being applied. Registration under REACH has to be made if bio-oil is produced or imported to the EU. In the USA and Canada, bio-oil has to be filed under TOSCA (US Toxic Substances Control Act). In this paper the state of the art on standardisation is discussed, and new data for the transportation guidelines is presented. The focus is on flammability and toxicity.

  17. Prospective Study of Local Control and Late Radiation Toxicity After Intraoperative Radiation Therapy Boost for Early Breast Cancer

    SciTech Connect (OSTI)

    Chang, David W.; Marvelde, Luc te; Chua, Boon H.

    2014-01-01

    Purpose: To report the local recurrence rate and late toxicity of intraoperative radiation therapy (IORT) boost to the tumor bed using the Intrabeam System followed by external-beam whole-breast irradiation (WBI) in women with early-stage breast cancer in a prospective single-institution study. Methods and Materials: Women with breast cancer ?3 cm were recruited between February 2003 and May 2005. After breast-conserving surgery, a single dose of 5 Gy IORT boost was delivered using 50-kV x-rays to a depth of 10 mm from the applicator surface. This was followed by WBI to a total dose of 50 Gy in 25 fractions. Patients were reviewed at regular, predefined intervals. Late toxicities were recorded using the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer Late Radiation Morbidity Scoring systems. Results: Fifty-five patients completed both IORT boost and external-beam WBI. Median follow-up was 3.3 years (range, 1.4-4.1 years). There was no reported locoregional recurrence or death. One patient developed distant metastases. Grade 2 and 3 subcutaneous fibrosis was detected in 29 (53%) and 8 patients (15%), respectively. Conclusions: The use of IORT as a tumor bed boost using kV x-rays in breast-conserving therapy was associated with good local control but a clinically significant rate of grade 2 and 3 subcutaneous fibrosis.

  18. High pressure, high current, low inductance, high reliability sealed terminals

    DOE Patents [OSTI]

    Hsu, John S. (Oak Ridge, TN) [Oak Ridge, TN; McKeever, John W. (Oak Ridge, TN) [Oak Ridge, TN

    2010-03-23

    The invention is a terminal assembly having a casing with at least one delivery tapered-cone conductor and at least one return tapered-cone conductor routed there-through. The delivery and return tapered-cone conductors are electrically isolated from each other and positioned in the annuluses of ordered concentric cones at an off-normal angle. The tapered cone conductor service can be AC phase conductors and DC link conductors. The center core has at least one service conduit of gate signal leads, diagnostic signal wires, and refrigerant tubing routed there-through. A seal material is in direct contact with the casing inner surface, the tapered-cone conductors, and the service conduits thereby hermetically filling the interstitial space in the casing interior core and center core. The assembly provides simultaneous high-current, high-pressure, low-inductance, and high-reliability service.

  19. Use of genomic data in risk assessment case study: I. Evaluation of the dibutyl phthalate male reproductive development toxicity data set

    SciTech Connect (OSTI)

    Makris, Susan L.; Euling, Susan Y.; Gray, L. Earl; Benson, Robert; Foster, Paul M.D.

    2013-09-15

    A case study was conducted, using dibutyl phthalate (DBP), to explore an approach to using toxicogenomic data in risk assessment. The toxicity and toxicogenomic data sets relative to DBP-related male reproductive developmental outcomes were considered conjointly to derive information about mode and mechanism of action. In this manuscript, we describe the case study evaluation of the toxicological database for DBP, focusing on identifying the full spectrum of male reproductive developmental effects. The data were assessed to 1) evaluate low dose and low incidence findings and 2) identify male reproductive toxicity endpoints without well-established modes of action (MOAs). These efforts led to the characterization of data gaps and research needs for the toxicity and toxicogenomic studies in a risk assessment context. Further, the identification of endpoints with unexplained MOAs in the toxicity data set was useful in the subsequent evaluation of the mechanistic information that the toxicogenomic data set evaluation could provide. The extensive analysis of the toxicology data set within the MOA context provided a resource of information for DBP in attempts to hypothesize MOAs (for endpoints without a well-established MOA) and to phenotypically anchor toxicogenomic and other mechanistic data both to toxicity endpoints and to available toxicogenomic data. This case study serves as an example of the steps that can be taken to develop a toxicological data source for a risk assessment, both in general and especially for risk assessments that include toxicogenomic data.

  20. High Temperature, High Pressure Devices for Zonal Isolation in...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Temperature, High Pressure Devices for Zonal Isolation in Geothermal Wells High Temperature, High Pressure Devices for Zonal Isolation in Geothermal Wells High Temperature, ...

  1. High strength, high ductility low carbon steel

    DOE Patents [OSTI]

    Koo, Jayoung (Berkeley, CA); Thomas, Gareth (Berkeley, CA)

    1978-01-01

    A high strength, high ductility low carbon steel consisting essentially of iron, 0.05-0.15 wt% carbon, and 1-3 wt% silicon. Minor amounts of other constituents may be present. The steel is characterized by a duplex ferrite-martensite microstructure in a fibrous morphology. The microstructure is developed by heat treatment consisting of initial austenitizing treatment followed by annealing in the (.alpha. + .gamma.) range with intermediate quenching.

  2. Biochemical solubilization of toxic salts from residual geothermal brines and waste waters

    DOE Patents [OSTI]

    Premuzic, E.T.; Lin, M.S.

    1994-11-22

    A method of solubilizing metal salts such as metal sulfides in a geothermal sludge using mutant Thiobacilli selected for their ability to metabolize metal salts at high temperature is disclosed. The method includes the introduction of mutated Thiobacillus ferrooxidans and Thiobacillus thiooxidans to a geothermal sludge or brine. The microorganisms catalyze the solubilization of metal salts. For instance, in the case of metal sulfides, the microorganisms catalyze the solubilization to form soluble metal sulfates. 54 figs.

  3. Biochemical solubilization of toxic salts from residual geothermal brines and waste waters

    DOE Patents [OSTI]

    Premuzic, Eugene T. (East Moriches, NY); Lin, Mow S. (Rocky Point, NY)

    1994-11-22

    A method of solubilizing metal salts such as metal sulfides in a geothermal sludge using mutant Thiobacilli selected for their ability to metabolize metal salts at high temperature is disclosed, The method includes the introduction of mutated Thiobacillus ferrooxidans and Thiobacillus thiooxidans to a geothermal sludge or brine. The microorganisms catalyze the solubilization of metal salts, For instance, in the case of metal sulfides, the microorganisms catalyze the solubilization to form soluble metal sulfates.

  4. 1997 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect (OSTI)

    Heather McBride

    1997-07-01

    The Emergency Planning and Community Right-to-Know Act of 1986 (EPCIL4), Title III, Section 313 [also known as the Superfund Amendment and Reauthorization Act (SARA)], as modified by Executive Order 12856, requires all federal facilities to submit an annual Toxic Chemical Release Inventory report every July for the preceding calendar year. Owners and operators of manufacturing, processing, or production facilities are required to report their toxic chemical releases to all environmental mediums (air, water, soil, etc.). At Los Alamos National Laboratory (LANL), nitric acid was the only toxic chemical used in 1997 that met the reportable threshold limit of 10,000 lb. Form R is the only documentation required by the Environmental Protection Agency, and it is included in the appendix of this report. This report, as requested by DOE, is provided for documentation purposes. In addition, a detailed description of the evaluation and reporting process for chemicals and processes at LANL has been included.

  5. Substrate inhibition and control for high rate biogas production

    SciTech Connect (OSTI)

    Shin, H.S.

    1982-01-01

    This research addresses a critical aspect of the technical feasibility of biogas recovery with poultry manure using anaerobic digestion, namely, inhibition and toxicity factors limiting methane generation under high rate conditions. The research was designed to identify the limiting factors and to examine alternative pretreatment and in situ control methods for the anaerobic digestion of poultry manure as an energy producing system. Biogas production was indicated by the daily gas volume produced per unit digester capacity. Enhanced biogas generation from the anaerobic digester systems using poultry manure was studied in laboratory- and pilot-scale digester operations. It was found that ammonia nitrogen concentration above 4000 mg/l was inhibitory to biogas production. Pretreatment of the manure by elutriation was effective for decreasing inhibitory/toxic conditions. Increased gas production resulted without an indication of serious inhibition by increased volatile acids, indicating a limitation of available carbon sources. For poultry manure digestion, the optimum pH range was 7.1 to 7.6. Annual costs for pretreatment/biogas systems for 10,000, 30,000 and 50,000 birds were estimated and compared with annual surplus energy produced. The economic break-even point was achieved in digesters for greater than 30,000 birds. Capital cost of the digester system was estimated to be $18,300 with annual costs around $4000. It is anticipated that the digester system could be economically applied to smaller farms as energy costs increase.

  6. Predictors of Grade 3 or Higher Late Bowel Toxicity in Patients Undergoing Pelvic Radiation for Cervical Cancer: Results From a Prospective Study

    SciTech Connect (OSTI)

    Chopra, Supriya; Dora, Tapas; Chinnachamy, Anand N.; Thomas, Biji; Kannan, Sadhna; Engineer, Reena; Mahantshetty, Umesh; Phurailatpam, Reena; Paul, Siji N.; Shrivastava, Shyam Kishore

    2014-03-01

    Purpose: The present study investigates relationship between dosevolume parameters and severe bowel toxicity after postoperative radiation treatment (PORT) for cervical cancer. Methods and Materials: From June 2010 to December 2012, a total of 71 patients undergoing PORT were included. Small bowel (SB) and large bowel (LB) loops were contoured 2cm above the target volume. The volume of SB and LB that received 15Gy, 30Gy, and 40Gy was calculated (V15 SB, V15 LB, V30 SB, V30 LB, V40 SB, V 40 LB). On follow-up, bowel toxicity was scored using Common Terminology Criteria for Adverse Events (CTCAE), version 3.0. A reciever operating characteristic (ROC) curve identified volume thresholds that predicted for grade 3 or higher toxicity with highest specificity. All data was dichotomized across these identified cut-off values. Univariate and multivariate analysis was performed using SPSS, version15. Results: The median patient age was 47years (range, 35-65years). Of the 71 patients, 46 received image-guided intensity modulated radiation therapy, and 25 received conformal radiation (50Gy in 25 fractions for 5weeks). Overall, 63 of 71 patients received concurrent chemotherapy. On a median follow-up of 18months (range, 8-29months), grade 2 or higher bowel toxicity was seen in 22 of 71 patients (30.9%) and grade 3 or higher bowel toxicity was seen in 9 patients (12.6%). On univariate analysis, V15 SB <275 cc (P=.01), V30 SB <190 cc (P=.02), V40 SB <150 cc (P=.01), and V15 LB <250 cc (P=.03), and V40 LB <90 cc (P=.04) predicted for absence of grade 3 or higher toxicity. No other patient- or treatment-related factors were statistically significant. On multivariate analysis, only V15 SB (P=.002) and V15 LB (P=.03) were statistically significant. Conclusions: V 15Gy SB and LB are independent predictors of late grade 3 or higher toxicity. Restricting V15 SB and V15 LB to <275 cc and <250 cc can reduce grade 3 or higher toxicity to less than 5%.

  7. Reduced Toxicity With Intensity Modulated Radiation Therapy (IMRT) for Desmoplastic Small Round Cell Tumor (DSRCT): An Update on the Whole Abdominopelvic Radiation Therapy (WAP-RT) Experience

    SciTech Connect (OSTI)

    Desai, Neil B.; Stein, Nicholas F.; LaQuaglia, Michael P.; Alektiar, Kaled M.; Kushner, Brian H.; Modak, Shakeel; Magnan, Heather M.; Goodman, Karyn; Wolden, Suzanne L.

    2013-01-01

    Purpose: Desmoplastic small round cell tumor (DSRCT) is a rare malignancy typically involving the peritoneum in young men. Whole abdominopelvic radiation therapy (WAP-RT) using conventional 2-dimensional (2D) radiation therapy (RT) is used to address local recurrence but has been limited by toxicity. Our objectives were to assess the benefit of intensity modulated radiation therapy (IMRT) on toxicity and to update the largest series on radiation for DSRCT. Methods and Materials: The records of 31 patients with DSRCT treated with WAP-RT (22 with 2D-RT and 9 with IMRT) between 1992 and 2011 were retrospectively reviewed. All received multi-agent chemotherapy and maximal surgical debulking followed by 30 Gy of WAP-RT. A further focal boost of 12 to 24 Gy was used in 12 cases. Boost RT and autologous stem cell transplantation were nearly exclusive to patients treated with 2D-RT. Toxicities were assessed with the Common Terminology Criteria for Adverse Events. Dosimetric analysis compared IMRT and simulated 2D-RT dose distributions. Results: Of 31 patients, 30 completed WAP-RT, with a median follow-up after RT of 19 months. Acute toxicity was reduced with IMRT versus 2D-RT: P=.04 for gastrointestinal toxicity of grade 2 or higher (33% vs 77%); P=.02 for grade 4 hematologic toxicity (33% vs 86%); P=.01 for rates of granulocyte colony-stimulating factor; and P=.04 for rates of platelet transfusion. Post treatment red blood cell and platelet transfusion rates were also reduced (P=.01). IMRT improved target homogeneity ([D05-D95]/D05 of 21% vs 46%) and resulted in a 21% mean bone dose reduction. Small bowel obstruction was the most common late toxicity (23% overall). Updated 3-year overall survival and progression-free survival rates were 50% and 24%, respectively. Overall survival was associated with distant metastasis at diagnosis on multivariate analysis. Most failures remained intraperitoneal (88%). Conclusions: IMRT for consolidative WAP-RT in DSRCT improves hematologic toxicity in particular. Although the long-term efficacy of current treatment options remains disappointing, the improved therapeutic index of IMRT may aid in generalizing its use and allowing the addition of novel approaches such as intraperitoneal immunotherapy.

  8. Pollution prevention opportunity assessment for the K-25 Site Toxic Substances Control Act Incinerator Operations, Level III

    SciTech Connect (OSTI)

    1995-09-01

    A Level III pollution prevention opportunity assessment (PPOA) was performed for the Oak Ridge K-25 Site Toxic Substances Control Act (TSCA) Incinerator to evaluate pollution prevention (P2) options for various waste streams: The main objective of this study was to identify and evaluate options to reduce the quantities of each waste stream generated by the TSCA Incinerator operations to realize significant environmental and/or economic benefits from P2. For each of the waste streams, P2 options were evaluated following the US Environmental Protection Agency (EPA) hierarchy to (1) reduce the quantity of waste generated, (2) recycle the waste, and/or (3) use alternate waste treatment or segregation methods. This report provides process descriptions, identification and evaluation of P2 options, and final recommendations.

  9. High Energy Physics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High Energy Physics /science-innovation/_assets/images/icon-science.jpg High Energy Physics Investigating the field of high energy physics through experiments that strengthen our fundamental understanding of matter, energy, space, and time. Advanced Scientific Computing Research Basic Energy Sciences Biological and Environmental Research Fusion Energy Sciences High Energy Physics Nuclear Physics Advanced Scientific Computing Research Pioneering accelerator technology to improve the intensity of

  10. High power microwave generator

    DOE Patents [OSTI]

    Ekdahl, Carl A. (Albuquerque, NM)

    1986-01-01

    A microwave generator efficiently converts the energy of an intense relativistic electron beam (REB) into a high-power microwave emission using the Smith-Purcell effect which is related to Cerenkov radiation. Feedback for efficient beam bunching and high gain is obtained by placing a cylindrical Smith-Purcell transmission grating on the axis of a toroidal resonator. High efficiency results from the use of a thin cold annular highly-magnetized REB that is closely coupled to the resonant structure.

  11. High power microwave generator

    DOE Patents [OSTI]

    Ekdahl, C.A.

    1983-12-29

    A microwave generator efficiently converts the energy of an intense relativistic electron beam (REB) into a high-power microwave emission using the Smith-Purcell effect which is related to Cerenkov radiation. Feedback for efficient beam bunching and high gain is obtained by placing a cylindrical Smith-Purcell transmission grating on the axis of a toroidal resonator. High efficiency results from the use of a thin cold annular highly-magnetized REB that is closely coupled to the resonant structure.

  12. High performance systems

    SciTech Connect (OSTI)

    Vigil, M.B.

    1995-03-01

    This document provides a written compilation of the presentations and viewgraphs from the 1994 Conference on High Speed Computing given at the High Speed Computing Conference, {open_quotes}High Performance Systems,{close_quotes} held at Gleneden Beach, Oregon, on April 18 through 21, 1994.

  13. High power, high beam quality regenerative amplifier

    DOE Patents [OSTI]

    Hackel, L.A.; Dane, C.B.

    1993-08-24

    A regenerative laser amplifier system generates high peak power and high energy per pulse output beams enabling generation of X-rays used in X-ray lithography for manufacturing integrated circuits. The laser amplifier includes a ring shaped optical path with a limited number of components including a polarizer, a passive 90 degree phase rotator, a plurality of mirrors, a relay telescope, and a gain medium, the components being placed close to the image plane of the relay telescope to reduce diffraction or phase perturbations in order to limit high peak intensity spiking. In the ring, the beam makes two passes through the gain medium for each transit of the optical path to increase the amplifier gain to loss ratio. A beam input into the ring makes two passes around the ring, is diverted into an SBS phase conjugator and proceeds out of the SBS phase conjugator back through the ring in an equal but opposite direction for two passes, further reducing phase perturbations. A master oscillator inputs the beam through an isolation cell (Faraday or Pockels) which transmits the beam into the ring without polarization rotation. The isolation cell rotates polarization only in beams proceeding out of the ring to direct the beams out of the amplifier. The diffraction limited quality of the input beam is preserved in the amplifier so that a high power output beam having nearly the same diffraction limited quality is produced.

  14. High power, high beam quality regenerative amplifier

    DOE Patents [OSTI]

    Hackel, Lloyd A. (Livermore, CA); Dane, Clifford B. (Livermore, CA)

    1993-01-01

    A regenerative laser amplifier system generates high peak power and high energy per pulse output beams enabling generation of X-rays used in X-ray lithography for manufacturing integrated circuits. The laser amplifier includes a ring shaped optical path with a limited number of components including a polarizer, a passive 90 degree phase rotator, a plurality of mirrors, a relay telescope, and a gain medium, the components being placed close to the image plane of the relay telescope to reduce diffraction or phase perturbations in order to limit high peak intensity spiking. In the ring, the beam makes two passes through the gain medium for each transit of the optical path to increase the amplifier gain to loss ratio. A beam input into the ring makes two passes around the ring, is diverted into an SBS phase conjugator and proceeds out of the SBS phase conjugator back through the ring in an equal but opposite direction for two passes, further reducing phase perturbations. A master oscillator inputs the beam through an isolation cell (Faraday or Pockels) which transmits the beam into the ring without polarization rotation. The isolation cell rotates polarization only in beams proceeding out of the ring to direct the beams out of the amplifier. The diffraction limited quality of the input beam is preserved in the amplifier so that a high power output beam having nearly the same diffraction limited quality is produced.

  15. High Tech Halloween

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High Tech Halloween High Tech Halloween WHEN: Oct 30, 2015 4:00 PM - 6:30 PM WHERE: Bradbury Science Museum 1350 Central Avenue, Los Alamos, New Mexico, 87544 USA CONTACT: Linda Anderman (505) 665-9196 CATEGORY: Bradbury INTERNAL: Calendar Login High Tech Halloween Event Description High-Tech Halloween is the Bradbury Science Museum's contribution to Downtown Los Alamos' annual Trick-or-Treat on MainStreet event taking place the Friday before Halloween. At this year's High-Tech Halloween, you

  16. K-1435 Wastewater Treatment System for the Toxic Substances Control Act Incinerator Wastewater at the East Tennessee Technology Park, Oak Ridge, TN

    SciTech Connect (OSTI)

    Beck, Ch.A.; Tiepel, E.W.; Swientoniewski, M.D.; Crow, K.R.

    2008-07-01

    This paper will discuss the design and performance of a wastewater treatment system installed to support the operation of a hazardous waste incinerator. The Oak Ridge Toxic Substances Control Act Incinerator (TSCAI), located at the East Tennessee Technology Park (ETTP), is designed and permitted to treat Resource Conservation and Recovery Act (RCRA) wastes including characteristic and listed wastes and polychlorinated biphenyl (PCB)-contaminated mixed waste. The incinerator process generates acidic gases and particulates which consist of salts, metals, and radionuclides. These off-gases from the incinerator are treated with a wet off-gas scrubber system. The recirculated water is continuously purged (blow down), resulting in a wastewater to be treated. Additional water sources are also collected on the site for treatment, including storm water that infiltrates into diked areas and fire water from the incinerator's suppression system. To meet regulatory requirements for discharge, a wastewater treatment system (WWTS) was designed, constructed, and operated to treat these water sources. The WWTS was designed to provide for periodic fluctuation of contaminant concentrations due to various feed streams to the incinerator. Blow down consists of total suspended solids (TSS) and total dissolved solids (TDS), encompassing metals, radionuclide contamination and trace organics. The system design flow rate range is 7.95 to 17 cubic meters per hour (m3/hr) (35 to 75 gallons per minute; gpm). The system is designed with redundancy to minimize time off-line and to reduce impacts to the TSCAI operations. A novel treatment system uses several unit operations, including chemical feed systems, two-stage chemical reaction treatment, micro-filtration, sludge storage and dewatering, neutralization, granular activated carbon, effluent neutralization, and a complete programmable logic controller (PLC) and human-machine interface (HMI) control system. To meet the space requirements and to provide portability of the WWTS to other applications, the system was installed in three, over-the-road semi trailers, and interconnected with piping and power. Trailers were oriented on a small site footprint to facilitate ease of installation. A remote sump pump skid was provided to convey water from two holding sumps adjacent to the treatment process. An accumulation tank and pump were also provided to receive miscellaneous wastewaters for treatment if they meet the waste acceptance criteria. The paper will include details of the technology used in the design, the requirements for compliance, and the initial performance demonstration and jar testing results. The WWTS successfully allowed for highly efficient, high-volume treatment with compliant discharge to off-site surface water. (authors)

  17. K-1435 Wastewater Treatment System for the Toxic Substances Control Act Incinerator Wastewater at the East Tennessee Technology Park, Oak Ridge, TN

    SciTech Connect (OSTI)

    Swientoniewski M.D.

    2008-02-24

    This paper discusses the design and performance of a wastewater treatment system installed to support the operation of a hazardous waste incinerator. The Oak Ridge Toxic Substances Control Act Incinerator (TSCAI), located at the East Tennessee Technology Park (ETTP), is designed and permitted to treat Resource ConservatioN and Recovery Act (RCRA) wastes including characteristic and listed wastes and polychlorinated biphenyl (PCB)-contaminated mixed waste. the incinerator process generates acidic gases and particulates which consist of salts, metals, and radionuclides. These off-gases from the incinerator are treated with a wet off-gas scrubber system. The recirculated water is continuously purged (below down), resulting in a wastewater to be treated. Additional water sources are also collected on the site for treatment, including storm water that infiltrates into diked areas and fire water from the incinerator's suppression system. To meet regulatory requirements for discharge, a wastewater treatment system (WWTS) was designed, constructed, and operated to treat these water sources. The WWTS was designed to provide for periodic fluctuation of contaminant concentrations due to various feed streams to the incinverator. Blow down consists of total suspended solids (TSS) and total dissolved solids (TDS), encompassing metals, radionuclide contamination and trace organics. The system design flow rate range is 35 to 75 gallons per minute (gpm). The system is designed with redundancy to minimize time off-line and to reduce impacts to the TSCAI operations. A novel treatment system uses several unit operations, including chemical feed systems, two-stage chemical reaction treatment, microfiltration, sludge storage and dewatering, neutralization, granular activated carbon, effluent neutralization, and a complete programmable logic controller (PLC) and human-machine interface (HMI) control system. To meet the space requirements and to provide portability of the WWTS to other applications, the system was installed in three, over-the-road semi trailers, and interconnected with piping and power. Trailers were oriented on a small site footprint to facilitate ease of installation. A remote sump pump skid was provided to convey water from two holding sumps adjacent to the treatment process. An accumulation tank and pump were also provided to receive miscellaneous wastewaters for treatment if they meet the waste acceptance criteria. The paper includes details of the technology used in the design, the requirements for compliance, and the initial performance demonstration and jar testing results. The WWTS successfully allowed for highly efficient, high-volume treatment with compliant discharge to off-site surface water.

  18. Insidious vapors: infrared determination of NO/sub 2/ generated in a high-voltage electric arc

    SciTech Connect (OSTI)

    Carlson, E.M.; LeFevre, P.G.; Williams, R.C.

    1984-11-01

    A study of the quantities of nitrogen dioxide generated by a high-voltage electric discharge was conducted. The amount of nitrogen dioxide present was measured using infrared spectroscopy. Paraffin was used to protect the KBr sample cell from damage and NO/sub 2/. The relative toxicities of phosgene and NO/sub 2/, both generated by arcing of electrical equipment, are presented. 10 references, 2 figures, 2 tables.

  19. Low Cost, High Temperature, High Ripple Current DC Bus Capacitors...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Low Cost, High Temperature, High Ripple Current DC Bus Capacitors Low Cost, High Temperature, High Ripple Current DC Bus Capacitors 2010 DOE Vehicle Technologies and Hydrogen...

  20. High-pressure, high-temperature plastic deformation of sintered...

    Office of Scientific and Technical Information (OSTI)

    Journal Article: High-pressure, high-temperature plastic deformation of sintered diamonds Citation Details In-Document Search Title: High-pressure, high-temperature plastic ...

  1. The high-pressure-high-temperature behavior of bassanite (Journal...

    Office of Scientific and Technical Information (OSTI)

    The high-pressure-high-temperature behavior of bassanite Citation Details In-Document Search Title: The high-pressure-high-temperature behavior of bassanite The pressure evolution ...

  2. Energy Storage Testing and Analysis High Power and High Energy...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Testing and Analysis High Power and High Energy Development Energy Storage Testing and Analysis High Power and High Energy Development 2009 DOE Hydrogen Program and Vehicle ...

  3. High pressure and high temperature apparatus

    DOE Patents [OSTI]

    Voronov, Oleg A.

    2005-09-13

    A design for high pressure/high temperature apparatus and reaction cell to achieve .about.30 GPa pressure in .about.1 cm volume and .about.100 GPa pressure in .about.1 mm volumes and 20-5000.degree. C. temperatures in a static regime. The device includes profiled anvils (28) action on a reaction cell (14, 16) containing the material (26) to be processed. The reaction cell includes a heater (18) surrounded by insulating layers and screens. Surrounding the anvils are cylindrical inserts and supporting rings (30-48) whose hardness increases towards the reaction cell. These volumes may be increased considerably if applications require it, making use of presses that have larger loading force capability, larger frames and using larger anvils.

  4. Herbicide_Application_Roads_CX-00020(2).pdf

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

  5. EA-2013 Herbicide FONSI 2016-02-05.pdf

    Office of Environmental Management (EM)

  6. High output lamp with high brightness

    DOE Patents [OSTI]

    Kirkpatrick, Douglas A.; Bass, Gary K.; Copsey, Jesse F.; Garber, Jr., William E.; Kwong, Vincent H.; Levin, Izrail; MacLennan, Donald A.; Roy, Robert J.; Steiner, Paul E.; Tsai, Peter; Turner, Brian P.

    2002-01-01

    An ultra bright, low wattage inductively coupled electrodeless aperture lamp is powered by a solid state RF source in the range of several tens to several hundreds of watts at various frequencies in the range of 400 to 900 MHz. Numerous novel lamp circuits and components are disclosed including a wedding ring shaped coil having one axial and one radial lead, a high accuracy capacitor stack, a high thermal conductivity aperture cup and various other aperture bulb configurations, a coaxial capacitor arrangement, and an integrated coil and capacitor assembly. Numerous novel RF circuits are also disclosed including a high power oscillator circuit with reduced complexity resonant pole configuration, parallel RF power FET transistors with soft gate switching, a continuously variable frequency tuning circuit, a six port directional coupler, an impedance switching RF source, and an RF source with controlled frequency-load characteristics. Numerous novel RF control methods are disclosed including controlled adjustment of the operating frequency to find a resonant frequency and reduce reflected RF power, controlled switching of an impedance switched lamp system, active power control and active gate bias control.

  7. 1998 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III

    SciTech Connect (OSTI)

    Marjorie B. Stockton

    1999-11-01

    The Emergency Planning and Community Right-to-Know Act (EPCRA) of 1986 [also known as the Superfund Amendment and Reauthorization Act (SARA), Title III], as modified by Executive Order 12856, requires that all federal facilities evaluate the need to submit an annual Toxic Chemical Release Inventory report as prescribed in Title III, Section 313 of this Act. This annual report is due every July for the preceding calendar year. Owners and operators who manufacture, process, or otherwise use certain toxic chemicals above listed threshold quantities are required to report their toxic chemical releases to all environmental mediums (air, water, soil, etc.). At Los Alamos National Laboratory (LANL), no EPCRA Section 313 chemicals were used in 1998 above the reportable threshold limits of 10,000 lb or 25,000 lb. Therefore LANL was not required to submit any Toxic Chemical Release Inventory reports (Form Rs) for 1998. This document was prepared to provide a detailed description of the evaluation on chemical usage and EPCRA Section 313 threshold determinations for LANL for 1998.

  8. Highly directional thermal emitter

    DOE Patents [OSTI]

    Ribaudo, Troy; Shaner, Eric A; Davids, Paul; Peters, David W

    2015-03-24

    A highly directional thermal emitter device comprises a two-dimensional periodic array of heavily doped semiconductor structures on a surface of a substrate. The array provides a highly directional thermal emission at a peak wavelength between 3 and 15 microns when the array is heated. For example, highly doped silicon (HDSi) with a plasma frequency in the mid-wave infrared was used to fabricate nearly perfect absorbing two-dimensional gratings structures that function as highly directional thermal radiators. The absorption and emission characteristics of the HDSi devices possessed a high degree of angular dependence for infrared absorption in the 10-12 micron range, while maintaining high reflectivity of solar radiation (.about.64%) at large incidence angles.

  9. High voltage coaxial switch

    DOE Patents [OSTI]

    Rink, J.P.

    1983-07-19

    A coaxial high voltage, high current switch having a solid cylindrical cold cathode coaxially surrounded by a thin hollow cylindrical inner electrode and a larger hollow cylindrical outer electrode. A high voltage trigger between the cathode and the inner electrode causes electrons to be emitted from the cathode and flow to the inner electrode preferably through a vacuum. Some of the electrons penetrate the inner electrode and cause a volumetric discharge in the gas (which may be merely air) between the inner and outer electrodes. The discharge provides a low impedance path between a high voltage charge placed on the outer electrode and a load (which may be a high power laser) coupled to the inner electrode. For high repetition rate the gas between the inner and outer electrodes may be continuously exchanged or refreshed under pressure. 3 figs.

  10. High voltage coaxial switch

    DOE Patents [OSTI]

    Rink, John P. (Los Alamos, NM)

    1983-07-19

    A coaxial high voltage, high current switch having a solid cylindrical cold cathode coaxially surrounded by a thin hollow cylindrical inner electrode and a larger hollow cylindrical outer electrode. A high voltage trigger between the cathode and the inner electrode causes electrons to be emitted from the cathode and flow to the inner electrode preferably through a vacuum. Some of the electrons penetrate the inner electrode and cause a volumetric discharge in the gas (which may be merely air) between the inner and outer electrodes. The discharge provides a low impedance path between a high voltage charge placed on the outer electrode and a load (which may be a high power laser) coupled to the inner electrode. For high repetition rate the gas between the inner and outer electrodes may be continuously exchanged or refreshed under pressure.

  11. High temperature furnace

    DOE Patents [OSTI]

    Borkowski, Casimer J.

    1976-08-03

    A high temperature furnace for use above 2000.degree.C is provided that features fast initial heating and low power consumption at the operating temperature. The cathode is initially heated by joule heating followed by electron emission heating at the operating temperature. The cathode is designed for routine large temperature excursions without being subjected to high thermal stresses. A further characteristic of the device is the elimination of any ceramic components from the high temperature zone of the furnace.

  12. High temperature refrigerator

    DOE Patents [OSTI]

    Steyert, Jr., William A.

    1978-01-01

    A high temperature magnetic refrigerator which uses a Stirling-like cycle in which rotating magnetic working material is heated in zero field and adiabatically magnetized, cooled in high field, then adiabatically demagnetized. During this cycle said working material is in heat exchange with a pumped fluid which absorbs heat from a low temperature heat source and deposits heat in a high temperature reservoir. The magnetic refrigeration cycle operates at an efficiency 70% of Carnot.

  13. High School Science Bowl

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High School Science Bowl High School Science Bowl WHEN: Feb 07, 2015 8:00 AM - 4:00 PM WHERE: Highland High School 4700 Coal Ave SE, Albuquerque, USA CATEGORY: Community INTERNAL: Calendar Login Event Description The Science Bowl is a Jeopardy-like event for high school and middle school students who have a strong interest in mathematics and science. The competition is in the form of a round robin in the morning and double elimination after lunch. Teams consist of four students and one optional

  14. High Energy Cost Grants

    Broader source: Energy.gov [DOE]

    The High Energy Cost Grant Program provides financial assistance for the improvement of energy generation, transmission, and distribution facilities servicing eligible rural communities with home...

  15. High Performance Sustainable Buildings

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    science and bioscience capabiities. Occupational Medicine will become a High Performance Sustainable Building in 2013. On the former County landfill, a photovoltaic array field...

  16. 2002 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect (OSTI)

    M. Stockton

    2003-11-01

    For reporting year 2002, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead compounds and mercury as required under the Emergency Planning and Community Right-to-Know Act (EPCRA), Section 313. No other EPCRA Section 313 chemicals were used in 2002 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical usage and threshold determinations for LANL for calendar year 2002 as well as provide background information about the data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventory report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999 EPA promulgated a final rule on Persistent Bioaccumulative Toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable under EPCRA Section 313. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.

  17. 2006 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect (OSTI)

    Ecology and Air Quality Group (ENV-EAQ)

    2007-12-12

    For reporting year 2006, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead as required under the Emergency Planning and Community Right-to-Know Act (EPCRA) Section 313. No other EPCRA Section 313 chemicals were used in 2006 above the reportable thresholds. This document was prepared to provide a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2006, as well as to provide background information about data included on the Form R reports. Section 313 of EPCRA specifically requires facilities to submit a Toxic Chemical Release Inventory Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. In 1999, EPA promulgated a final rule on persistent bioaccumulative toxics (PBTs). This rule added several chemicals to the EPCRA Section 313 list of toxic chemicals and established lower reporting thresholds for these and other PBT chemicals that were already reportable. These lower thresholds became applicable in reporting year 2000. In 2001, EPA expanded the PBT rule to include a lower reporting threshold for lead and lead compounds. Facilities that manufacture, process, or otherwise use more than 100 lb of lead or lead compounds must submit a Form R.

  18. High power, high frequency, vacuum flange

    DOE Patents [OSTI]

    Felker, Brian (Livermore, CA); McDaniel, Michael R. (Manteca, CA)

    1993-01-01

    An improved waveguide flange is disclosed for high power operation that helps prevent arcs from being initiated at the junctions between waveguide sections. The flanges at the end of the waveguide sections have counterbores surrounding the waveguide tubes. When the sections are bolted together the counterbores form a groove that holds a fully annealed copper gasket. Each counterbore has a beveled step that is specially configured to insure the gasket forms a metal-to-metal vacuum seal without gaps or sharp edges. The resultant inner surface of the waveguide is smooth across the junctions between waveguide sections, and arcing is prevented.

  19. High power, high frequency, vacuum flange

    DOE Patents [OSTI]

    Felker, B.; McDaniel, M.R.

    1993-03-23

    An improved waveguide flange is disclosed for high power operation that helps prevent arcs from being initiated at the junctions between waveguide sections. The flanges at the end of the waveguide sections have counter bores surrounding the waveguide tubes. When the sections are bolted together the counter bores form a groove that holds a fully annealed copper gasket. Each counterbore has a beveled step that is specially configured to insure the gasket forms a metal-to-metal vacuum seal without gaps or sharp edges. The resultant inner surface of the waveguide is smooth across the junctions between waveguide sections, and arcing is prevented.

  20. High coking value pitch

    SciTech Connect (OSTI)

    Miller, Douglas J.; Chang, Ching-Feng; Lewis, Irwin C.; Lewis, Richard T.

    2014-06-10

    A high coking value pitch prepared from coal tar distillate and has a low softening point and a high carbon value while containing substantially no quinoline insolubles is disclosed. The pitch can be used as an impregnant or binder for producing carbon and graphite articles.

  1. High density photovoltaic

    SciTech Connect (OSTI)

    Haigh, R.E.; Jacobson, G.F.; Wojtczuk, S.

    1997-10-14

    Photovoltaic technology can directly generate high voltages in a solid state material through the series interconnect of many photovoltaic diodes. We are investigating the feasibility of developing an electrically isolated, high-voltage power supply using miniature photovoltaic devices that convert optical energy to electrical energy.

  2. High temperature sensor

    DOE Patents [OSTI]

    Tokarz, Richard D.

    1982-01-01

    A high temperature sensor includes a pair of electrical conductors separated by a mass of electrical insulating material. The insulating material has a measurable resistivity within the sensor that changes in relation to the temperature of the insulating material within a high temperature range (1,000 to 2,000 K.). When required, the sensor can be encased within a ceramic protective coating.

  3. High Explosives Testing

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High Explosives Testing High Explosives Testing In the 1940s, high explosives were tested at Los Alamos. August 1, 2013 The design and testing for "Little Boy" took place at Gun Site The design and testing for "Little Boy" took place at Gun Site. RELATED IMAGES http://farm8.staticflickr.com/7390/9778165821_9976c43bda_t.jpg Enlarge http://farm4.staticflickr.com/3817/9631800990_1c130beec7

  4. Projections of air toxic emissions from coal-fired utility combustion: Input for hazardous air pollutant regulators

    SciTech Connect (OSTI)

    Szpunar, C.B.

    1993-08-01

    The US Environmental Protection Agency (EPA) is required by the 1990 CAAA to promulgate rules for all ``major`` sources of any of these HAPs. According to the HAPs section of the new Title III, any stationary source emitting 10 tons per year (TPY) of one HAP or 25 TPY of a combination of HAPs will be considered and designated a major source. In contrast to the original National Emission Standards for Hazardous Air Pollutants (NESHAP), which were designed to protect public health to ``an ample margin of safety,`` the new Title III, in its first phase, will regulate by industrial category those sources emitting HAPs in excess of the 10/25-TPY threshold levels, regardless of health risks. The trace elements normally associated with coal mineral matter and the various compounds formed during coal combustion have the potential to produce hazardous air toxic emissions from coal-fired electric utilities. Under Title III, the EPA is required to perform certain studies, prior to any regulation of electric utilities; these studies are currently underway. Also, the US Department of Energy (DOE) maintains a vested interest in addressing those energy policy questions affecting electric utility generation, coal mining, and steel producing critical to this country`s economic well-being, where balancing the costs to the producers and users of energy with the benefits of environmental protection to the workers and the general populace remains of significant concern.

  5. Toxic Substances Control Act (TSCA) Polychlorinated Biphenyl (PCB)/Radioactive Waste Annual Inventory for Calendar Year 2014

    SciTech Connect (OSTI)

    Layton, Deborah L.

    2015-06-01

    The Toxic Substances Control Act, 40 CFR 761.65(a)(1) provides an exemption from the one year storage time limit for PCB/radioactive waste. PCB/radioactive waste may exceed the one year time limit provided that the provisions at 40 CFR 761.65(a)(2)(ii) and 40 CFR 761.65(a)(2)(iii) are followed. These two subsections require, (ii) "A written record documenting all continuing attempts to secure disposal is maintained until the waste is disposed of" and (iii) "The written record required by subsection (ii) of this section is available for inspection or submission if requested by EPA." EPA Region 10 has requested the Department of Energy (DOE) to submit an inventory of radioactive-contaminated PCB waste in storage at the Idaho National Laboratory (INL) for the previous calendar year. The annual inventory is separated into two parts, INL without Advanced Mixed Waste Treatment Project (AMWTP) (this includes Battelle Energy Alliance, LLC, CH2M-WG Idaho, LLC, and the Naval Reactors Facility), and AMWTP.

  6. Toxic Substances Control Act (TSCA) Polychlorinated Biphenyl (PCB)/Radioactive Waste Annual Inventory for Calendar Year 2013

    SciTech Connect (OSTI)

    no author on report

    2014-06-01

    The Toxic Substances Control Act, 40 CFR 761.65(a)(1) provides an exemption from the one year storage time limit for PCB/radioactive waste. PCB/radioactive waste may exceed the one year time limit provided that the provisions at 40 CFR 761.65(a)(2)(ii) and 40 CFR 761.65(a)(2)(iii) are followed. These two subsections require, (ii) "A written record documenting all continuing attempts to secure disposal is maintained until the waste is disposed of" and (iii) "The written record required by subsection (ii) of this section is available for inspection or submission if requested by EPA." EPA Region 10 has requested the Department of Energy (DOE) to submit an inventory of radioactive-contaminated PCB waste in storage at the Idaho National Laboratory (INL) for the previous calendar year. The annual inventory is separated into two parts, INL without Advanced Mixed Waste Treatment Project (AMWTP) (this includes Battelle Energy Alliance, LLC, CH2M-WG Idaho, LLC, and the Naval Reactors Facility), and AMWTP.

  7. Technical evaluation of topsoil substitution practices and handling of potential acid/toxic-forming materials in Texas. Special study report

    SciTech Connect (OSTI)

    Not Available

    1985-09-01

    The Texas State program approved by the Office of Surface Mining (OSM) under the Surface Mining Control and Reclamation Act of 1977 (SMCRA) allows that selected overburden materials may, if justified, be substituted for topsoil in mined land reclamation. The report presents the Office of Surface Mining Reclamation and Enforcement's (OSM's) findings regarding the practice of topsoil substitution under the approved Texas program and related reclamation problems with potential minesoil acidification. The purpose of the study was not to determine whether the substitution of overburden for topsoil should be approved or disapproved on any specific mine or soil series in Texas. The report presents a summary of pertinent technical considerations that need to be addressed in permit approvals for surface coal mines which (1) may encounter potentially acid/toxic-forming materials during mining or (2) intend to substitute overburden for topsoil as a plant growth material. The report summarizes the results of a special study OSM conducted to evaluate the technical basis and justification for reclamation plans and the substitution of overburden for topsoil as a plant growth material suitable for the reclamation of coal mines.

  8. High Performance Sustainable Building

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-11-09

    This Guide highlights the DOE O 413.3B drivers for incorporating high performance sustainable building (HPSB) principles into Critical Decisions 1 through 4 and provides guidance for implementing the Order's HPSB requirements.

  9. High Performance Sustainable Building

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2011-11-09

    This Guide provides approaches for implementing the High Performance Sustainable Building (HPSB) requirements of DOE Order 413.3B, Program and Project Management for the Acquisition of Capital Assets. Supersedes DOE G 413.3-6.

  10. High pressure furnace

    DOE Patents [OSTI]

    Morris, D.E.

    1993-09-14

    A high temperature high pressure furnace has a hybrid partially externally heated construction. A metallic vessel fabricated from an alloy having a composition of at least 45% nickel, 15% chrome, and 10% tungsten is utilized (the preferred alloy including 55% nickel, 22% chrome, 14% tungsten, 2% molybdenum, 3% iron (maximum) and 5% cobalt (maximum)). The disclosed alloy is fabricated into 11/4 or 2 inch, 32 mm or 50 mm bar stock and has a length of about 22 inches, 56 cm. This bar stock has an aperture formed therein to define a closed high temperature, high pressure oxygen chamber. The opposite and closed end of the vessel is provided with a small blind aperture into which a thermocouple can be inserted. The closed end of the vessel is inserted into an oven, preferably heated by standard nickel chrome electrical elements and having a heavily insulated exterior. 19 figures.

  11. High pressure furnace

    DOE Patents [OSTI]

    Morris, Donald E. (Kensington, CA)

    1993-01-01

    A high temperature high pressure furnace has a hybrid partially externally heated construction. A metallic vessel fabricated from an alloy having a composition of at least 45% nickel, 15% chrome, and 10% tungsten is utilized (the preferred alloy including 55% nickel, 22% chrome, 14% tungsten, 2% molybdenum, 3% iron (maximum) and 5% cobalt (maximum). The disclosed alloy is fabricated into 11/4 or 2 inch, 32 mm or 50 mm bar stock and has a length of about 22 inches, 56 cm. This bar stock has an aperture formed therein to define a closed high temperature, high pressure oxygen chamber. The opposite and closed end of the vessel is provided with a small blind aperture into which a thermocouple can be inserted. The closed end of the vessel is inserted into an oven, preferably heated by standard nickel chrome electrical elements and having a heavily insulated exterior.

  12. High pressure oxygen furnace

    DOE Patents [OSTI]

    Morris, Donald E. (Kensington, CA)

    1992-01-01

    A high temperature high pressure oxygen furnace having a hybrid partially externally heated construction is disclosed. A metallic bar fabricated from an alloy having a composition of at least 45% nickel, 15% chrome, and 10% tungsten is utilized (the preferred alloy including 55% nickel, 22% chrome, 14% tungsten, 2% molybdenum, 3% iron (maximum) and 5% cobalt (maximum). The disclosed alloy is fabricated into 11/4 inch bar stock and has a length of about 17 inches. This bar stock is gun drilled for over 16 inches of its length with 0.400 inch aperture to define a closed high temperature, high pressure oxygen chamber. The opposite and closed end of the bar is provided with a small support aperture into which both a support and a thermocouple can be inserted. The closed end of the gun drilled bar is inserted into an oven, preferably heated by standard nickel chrome electrical elements and having a heavily insulated exterior.

  13. High pressure oxygen furnace

    DOE Patents [OSTI]

    Morris, D.E.

    1992-07-14

    A high temperature high pressure oxygen furnace having a hybrid partially externally heated construction is disclosed. A metallic bar fabricated from an alloy having a composition of at least 45% nickel, 15% chrome, and 10% tungsten is utilized, the preferred alloy including 55% nickel, 22% chrome, 14% tungsten, 2% molybdenum, 3% iron (maximum) and 5% cobalt (maximum). The disclosed alloy is fabricated into 11/4 inch bar stock and has a length of about 17 inches. This bar stock is gun drilled for over 16 inches of its length with 0.400 inch aperture to define a closed high temperature, high pressure oxygen chamber. The opposite and closed end of the bar is provided with a small support aperture into which both a support and a thermocouple can be inserted. The closed end of the gun drilled bar is inserted into an oven, preferably heated by standard nickel chrome electrical elements and having a heavily insulated exterior. 5 figs.

  14. High-Temperature Superconductivity

    ScienceCinema (OSTI)

    Peter Johnson

    2010-01-08

    Like astronomers tweaking images to gain a more detailed glimpse of distant stars, physicists at Brookhaven National Laboratory have found ways to sharpen images of the energy spectra in high-temperature superconductors ? materials that carry electrical c

  15. High-Speed Photography

    SciTech Connect (OSTI)

    Paisley, D.L.; Schelev, M.Y.

    1998-08-01

    The applications of high-speed photography to a diverse set of subjects including inertial confinement fusion, laser surgical procedures, communications, automotive airbags, lightning etc. are briefly discussed. (AIP) {copyright} {ital 1998 Society of Photo-Optical Instrumentation Engineers.}

  16. High temperature pressure gauge

    DOE Patents [OSTI]

    Echtler, J. Paul (Pittsburgh, PA); Scandrol, Roy O. (Library, PA)

    1981-01-01

    A high temperature pressure gauge comprising a pressure gauge positioned in fluid communication with one end of a conduit which has a diaphragm mounted in its other end. The conduit is filled with a low melting metal alloy above the diaphragm for a portion of its length with a high temperature fluid being positioned in the remaining length of the conduit and in the pressure gauge.

  17. High efficiency incandescent lighting

    DOE Patents [OSTI]

    Bermel, Peter; Ilic, Ognjen; Chan, Walker R.; Musabeyoglu, Ahmet; Cukierman, Aviv Ruben; Harradon, Michael Robert; Celanovic, Ivan; Soljacic, Marin

    2014-09-02

    Incandescent lighting structure. The structure includes a thermal emitter that can, but does not have to, include a first photonic crystal on its surface to tailor thermal emission coupled to, in a high-view-factor geometry, a second photonic filter selected to reflect infrared radiation back to the emitter while passing visible light. This structure is highly efficient as compared to standard incandescent light bulbs.

  18. High Performance Sustainable Buildings

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Buildings Goal 3: High Performance Sustainable Buildings Maintaining the conditions of a building improves the health of not only the surrounding ecosystems, but also the well-being of its occupants. Energy Conservation» Efficient Water Use & Management» High Performance Sustainable Buildings» Greening Transportation» Green Purchasing & Green Technology» Pollution Prevention» Science Serving Sustainability» ENVIRONMENTAL SUSTAINABILITY GOALS at LANL The Radiological Laboratory

  19. High Temperature Aqueous Chemistry

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accurate knowledge of aqueous chemistry at high temperatures and pressures is important in many applications including nuclear waste disposal and energy extraction. Sandia's Defense Waste Management Programs is equipped with a state-of-the-art hydrothermal experimental system that allows us to obtain high quality kinetic and equilibrium data at temperatures and pressures of interest up to 600 o C and 1,000 bars (100 MPa). This state-of-the-art hydrothermal experimental system includes the

  20. High-temperature sensor

    DOE Patents [OSTI]

    Not Available

    1981-01-29

    A high temperature sensor is described which includes a pair of electrical conductors separated by a mass of electrical insulating material. The insulating material has a measurable resistivity within the sensor that changes in relation to the temperature of the insulating material within a high temperature range (1000 to 2000/sup 0/K). When required, the sensor can be encased within a ceramic protective coating.

  1. High conductivity composite metal

    DOE Patents [OSTI]

    Zhou, R.; Smith, J.L.; Embury, J.D.

    1998-01-06

    Electrical conductors and methods of producing them are disclosed, where the conductors possess both high strength and high conductivity. Conductors are comprised of carbon steel and a material chosen from a group consisting of copper, nickel, silver, and gold. Diffusion barriers are placed between these two materials. The components of a conductor are assembled and then the assembly is subjected to heat treating and mechanical deformation steps. 10 figs.

  2. High conductivity composite metal

    DOE Patents [OSTI]

    Zhou, Ruoyi; Smith, James L.; Embury, John David

    1998-01-01

    Electrical conductors and methods of producing them, where the conductors possess both high strength and high conductivity. Conductors are comprised of carbon steel and a material chosen from a group consisting of copper, nickel, silver, and gold. Diffusion barriers are placed between these two materials. The components of a conductor are assembled and then the assembly is subjected to heat treating and mechanical deformation steps.

  3. High Burnup Effects Program

    SciTech Connect (OSTI)

    Barner, J.O.; Cunningham, M.E.; Freshley, M.D.; Lanning, D.D.

    1990-04-01

    This is the final report of the High Burnup Effects Program (HBEP). It has been prepared to present a summary, with conclusions, of the HBEP. The HBEP was an international, group-sponsored research program managed by Battelle, Pacific Northwest Laboratories (BNW). The principal objective of the HBEP was to obtain well-characterized data related to fission gas release (FGR) for light water reactor (LWR) fuel irradiated to high burnup levels. The HBEP was organized into three tasks as follows: Task 1 -- high burnup effects evaluations; Task 2 -- fission gas sampling; and Task 3 -- parameter effects study. During the course of the HBEP, a program that extended over 10 years, 82 fuel rods from a variety of sources were characterized, irradiated, and then examined in detail after irradiation. The study of fission gas release at high burnup levels was the principal objective of the program and it may be concluded that no significant enhancement of fission gas release at high burnup levels was observed for the examined rods. The rim effect, an as yet unquantified contributor to athermal fission gas release, was concluded to be the one truly high-burnup effect. Though burnup enhancement of fission gas release was observed to be low, a full understanding of the rim region and rim effect has not yet emerged and this may be a potential area of further research. 25 refs., 23 figs., 4 tabs.

  4. High Reliability, High TemperatureThermoelectric Power Generation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Reliability, High TemperatureThermoelectric Power Generation Materials and Technologies High Reliability, High TemperatureThermoelectric Power Generation Materials and Technologies...

  5. High surface area, high permeability carbon monoliths

    SciTech Connect (OSTI)

    Lagasse, R.R.; Schroeder, J.L. [Sandia National Labs., Albuquerque, NM (United States). Organic Materials Processing Dept.

    1994-12-31

    The goal of this work is to prepare carbon monoliths having precisely tailored pore size distribution. Prior studies have demonstrated that poly(acrylonitrile) can be processed into a precursor having tailored macropore structure. Since the macropores were preserved during pyrolysis, this synthetic process provided a route to porous carbon having macropores with size =0.1 to 10{mu}m. No micropores of size <2 nm could be detected in the carbon, however, by nitrogen adsorption. In the present work, the authors have processed a different polymer, poly(vinylidene chloride) into a macroporous precursor, Pyrolysis produced carbon monoliths having macropores derived from the polymer precursor as well as extensive microporosity produced during the pyrolysis of the polymer. One of these carbons had BET surface area of 1,050 m{sup 2}/g and about 1.2 cc/g total pore volume, with about 1/3 of the total pore volume in micropores and the remainder in 1{mu}m macropores. No mesopores in the intermediate size range could be detected by nitrogen adsorption. Carbon materials having high surface area as well as micron size pores have potential applications as electrodes for double layer supercapacitors containing liquid electrolyte, or as efficient media for performing chemical separations.

  6. Partitioning planning studies: Preliminary evaluation of metal and radionuclide partitioning the high-temperature thermal treatment systems

    SciTech Connect (OSTI)

    Liekhus, K.; Grandy, J.; Chambers, A.

    1997-03-01

    A preliminary study of toxic metals and radionuclide partitioning during high-temperature processing of mixed waste has been conducted during Fiscal Year 1996 within the Environmental Management Technology Evaluation Project. The study included: (a) identification of relevant partitioning mechanisms that cause feed material to be distributed between the solid, molten, and gas phases within a thermal treatment system; (b) evaluations of existing test data from applicable demonstration test programs as a means to identify and understand elemental and species partitioning; and, (c) evaluation of theoretical or empirical partitioning models for use in predicting elemental or species partitioning in a thermal treatment system. This preliminary study was conducted to identify the need for and the viability of developing the tools capable of describing and predicting toxic metals and radionuclide partitioning in the most applicable mixed waste thermal treatment processes. This document presents the results and recommendations resulting from this study that may serve as an impetus for developing and implementing these predictive tools.

  7. UbiQD Named Top High-Growth Company and Job Creator in Northern New Mexico,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Closes Round of Financing UbiQD Named Top High-Growth Company UbiQD Honored with a Northern New Mexico 20/20 Award Honored with a Northern New Mexico 20/20 Award November 17, 2015 Dr. Matt Bergren, UbiQD Director of Applied Physics, left, and UbiQD Founder and President Dr. Hunter McDaniel Dr. Matt Bergren, UbiQD Director of Applied Physics, left, and UbiQD Founder and President Dr. Hunter McDaniel hold jars of quantum dots illuminated by blue LED flashlights. The low-toxicity, low-cost

  8. The high-pressure-high-temperature behavior of bassanite (Journal...

    Office of Scientific and Technical Information (OSTI)

    The high-pressure-high-temperature behavior of bassanite Citation Details In-Document Search Title: The high-pressure-high-temperature behavior of bassanite The pressure evolution of ...

  9. High-Pressure and High-Temperature Powder Diffraction (Journal...

    Office of Scientific and Technical Information (OSTI)

    High-Pressure and High-Temperature Powder Diffraction Citation Details In-Document Search Title: High-Pressure and High-Temperature Powder Diffraction Authors: Fei, Yingwei ; Wang, ...

  10. Advances in exposure and toxicity assessment of particulate matter: An overview of presentations at the 2009 Toxicology and Risk Assessment Conference

    SciTech Connect (OSTI)

    Gunasekar, Palur G.; Stanek, Lindsay W.

    2011-07-15

    The 2009 Toxicology and Risk Assessment Conference (TRAC) session on 'Advances in Exposure and Toxicity Assessment of Particulate Matter' was held in April 2009 in West Chester, OH. The goal of this session was to bring together toxicology, geology and risk assessment experts from the Department of Defense and academia to examine issues in exposure assessment and report on recent epidemiological findings of health effects associated with particulate matter (PM) exposure. Important aspects of PM exposure research are to detect and monitor low levels of PM with various chemical compositions and to assess the health risks associated with these exposures. As part of the overall theme, some presenters discussed collection methods for sand and dust from Iraqi and Afghanistan regions, health issues among deployed personnel, and future directions for risk assessment research among these populations. The remaining speakers focused on the toxicity of ultrafine PM and the characterization of aerosols generated during ballistic impacts of tungsten heavy alloys.

  11. Sandia Energy - High Performance Computing

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High Performance Computing Home Energy Research Advanced Scientific Computing Research (ASCR) High Performance Computing High Performance Computingcwdd2015-03-18T21:41:24+00:00...

  12. Sandia Energy - High Pressure Chemistry

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High Pressure Chemistry Home Transportation Energy Predictive Simulation of Engines Combustion Chemistry Combustion Kinetics High Pressure Chemistry High Pressure ChemistryAshley...

  13. High Temperature, High Pressure Devices for Zonal Isolation in Geothermal

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Wells | Department of Energy High Temperature, High Pressure Devices for Zonal Isolation in Geothermal Wells High Temperature, High Pressure Devices for Zonal Isolation in Geothermal Wells High Temperature, High Pressure Devices for Zonal Isolation in Geothermal Wells PDF icon fabian_ctd_ zonal_isolation_peer2013.pdf More Documents & Publications High Temperature, High Pressure Devices for Zonal Isolation in Geothermal Wells track 3: enhanced geothermal systems (EGS) | geothermal 2015

  14. High-Temperature-High-Volume Lifting for Enhanced Geothermal Systems |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy High-Temperature-High-Volume Lifting for Enhanced Geothermal Systems High-Temperature-High-Volume Lifting for Enhanced Geothermal Systems High-Temperature-High-Volume Lifting for Enhanced Geothermal Systems presentation at the April 2013 peer review meeting held in Denver, Colorado. PDF icon turnquist_high_temp_tools_peer2013.pdf More Documents & Publications High-Temperature Motor Windings for Downhole Pumps Used in Geothermal Energy Production

  15. High-energy detector

    DOE Patents [OSTI]

    Bolotnikov, Aleksey E.; Camarda, Giuseppe; Cui, Yonggang; James, Ralph B.

    2011-11-22

    The preferred embodiments are directed to a high-energy detector that is electrically shielded using an anode, a cathode, and a conducting shield to substantially reduce or eliminate electrically unshielded area. The anode and the cathode are disposed at opposite ends of the detector and the conducting shield substantially surrounds at least a portion of the longitudinal surface of the detector. The conducting shield extends longitudinally to the anode end of the detector and substantially surrounds at least a portion of the detector. Signals read from one or more of the anode, cathode, and conducting shield can be used to determine the number of electrons that are liberated as a result of high-energy particles impinge on the detector. A correction technique can be implemented to correct for liberated electron that become trapped to improve the energy resolution of the high-energy detectors disclosed herein.

  16. High brightness electron accelerator

    DOE Patents [OSTI]

    Sheffield, Richard L. (Los Alamos, NM); Carlsten, Bruce E. (Los Alamos, NM); Young, Lloyd M. (Los Alamos, NM)

    1994-01-01

    A compact high brightness linear accelerator is provided for use, e.g., in a free electron laser. The accelerator has a first plurality of acclerating cavities having end walls with four coupling slots for accelerating electrons to high velocities in the absence of quadrupole fields. A second plurality of cavities receives the high velocity electrons for further acceleration, where each of the second cavities has end walls with two coupling slots for acceleration in the absence of dipole fields. The accelerator also includes a first cavity with an extended length to provide for phase matching the electron beam along the accelerating cavities. A solenoid is provided about the photocathode that emits the electons, where the solenoid is configured to provide a substantially uniform magnetic field over the photocathode surface to minimize emittance of the electons as the electrons enter the first cavity.

  17. High resolution data acquisition

    DOE Patents [OSTI]

    Thornton, Glenn W.; Fuller, Kenneth R.

    1993-01-01

    A high resolution event interval timing system measures short time intervals such as occur in high energy physics or laser ranging. Timing is provided from a clock (38) pulse train (37) and analog circuitry (44) for generating a triangular wave (46) synchronously with the pulse train (37). The triangular wave (46) has an amplitude and slope functionally related to the time elapsed during each clock pulse in the train. A converter (18, 32) forms a first digital value of the amplitude and slope of the triangle wave at the start of the event interval and a second digital value of the amplitude and slope of the triangle wave at the end of the event interval. A counter (26) counts the clock pulse train (37) during the interval to form a gross event interval time. A computer (52) then combines the gross event interval time and the first and second digital values to output a high resolution value for the event interval.

  18. High resolution data acquisition

    DOE Patents [OSTI]

    Thornton, G.W.; Fuller, K.R.

    1993-04-06

    A high resolution event interval timing system measures short time intervals such as occur in high energy physics or laser ranging. Timing is provided from a clock, pulse train, and analog circuitry for generating a triangular wave synchronously with the pulse train (as seen in diagram on patent). The triangular wave has an amplitude and slope functionally related to the time elapsed during each clock pulse in the train. A converter forms a first digital value of the amplitude and slope of the triangle wave at the start of the event interval and a second digital value of the amplitude and slope of the triangle wave at the end of the event interval. A counter counts the clock pulse train during the interval to form a gross event interval time. A computer then combines the gross event interval time and the first and second digital values to output a high resolution value for the event interval.

  19. UbiQD Named Top High-Growth Company and Job Creator in Northern New Mexico, Closes Round of Financing

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    UbiQD Named Top High-Growth Company and Job Creator in Northern New Mexico, Closes Round of Financing November 17, 2015 UbiQD, LLC, a low-toxicity, low-cost quantum dot manufacturer, was recently recognized with a Northern New Mexico 20/20 Award that identifies high-growth companies driving regional economic growth. This award follows on the heels of a general upswing in UbiQD's business. The company closed a new investment round, bringing the total financing to more than $700,000; welcomed Dr.

  20. High strength alloys

    DOE Patents [OSTI]

    Maziasz, Phillip James [Oak Ridge, TN; Shingledecker, John Paul [Knoxville, TN; Santella, Michael Leonard [Knoxville, TN; Schneibel, Joachim Hugo [Knoxville, TN; Sikka, Vinod Kumar [Oak Ridge, TN; Vinegar, Harold J [Bellaire, TX; John, Randy Carl [Houston, TX; Kim, Dong Sub [Sugar Land, TX

    2010-08-31

    High strength metal alloys are described herein. At least one composition of a metal alloy includes chromium, nickel, copper, manganese, silicon, niobium, tungsten and iron. System, methods, and heaters that include the high strength metal alloys are described herein. At least one heater system may include a canister at least partially made from material containing at least one of the metal alloys. At least one system for heating a subterranean formation may include a tubular that is at least partially made from a material containing at least one of the metal alloys.

  1. High strength alloys

    DOE Patents [OSTI]

    Maziasz, Phillip James; Shingledecker, John Paul; Santella, Michael Leonard; Schneibel, Joachim Hugo; Sikka, Vinod Kumar; Vinegar, Harold J.; John, Randy Carl; Kim, Dong Sub

    2012-06-05

    High strength metal alloys are described herein. At least one composition of a metal alloy includes chromium, nickel, copper, manganese, silicon, niobium, tungsten and iron. System, methods, and heaters that include the high strength metal alloys are described herein. At least one heater system may include a canister at least partially made from material containing at least one of the metal alloys. At least one system for heating a subterranean formation may include a tublar that is at least partially made from a material containing at least one of the metal alloys.

  2. High Availability Electronics Standards

    SciTech Connect (OSTI)

    Larsen, R.S.; /SLAC

    2006-12-13

    Availability modeling of the proposed International Linear Collider (ILC) predicts unacceptably low uptime with current electronics systems designs. High Availability (HA) analysis is being used as a guideline for all major machine systems including sources, utilities, cryogenics, magnets, power supplies, instrumentation and controls. R&D teams are seeking to achieve total machine high availability with nominal impact on system cost. The focus of this paper is the investigation of commercial standard HA architectures and packaging for Accelerator Controls and Instrumentation. Application of HA design principles to power systems and detector instrumentation are also discussed.

  3. TOXICITY CHARACTERISTIC LEACHING PROCEDURE APPLIED TO RADIOACTIVE SALTSTONE CONTAINING TETRAPHENYLBORATE: DEVELOPMENT OF A MODIFIED ZERO-HEADSPACE EXTRACTOR

    SciTech Connect (OSTI)

    Crapse, K.; Cozzi, A.; Crawford, C.; Jurgensen, A.

    2006-09-30

    In order to assess the effect of extended curing times at elevated temperatures on saltstone containing Tank 48H waste, saltstone samples prepared as a part of a separate study were analyzed for benzene using a modification of the United States Environmental Protection Agency (USEPA) method 1311 Toxicity Characteristic Leaching Procedure (TCLP). To carry out TCLP for volatile organic analytes (VOA), such as benzene, in the Savannah River National Laboratory (SRNL) shielded cells (SC), a modified TCLP Zero-Headspace Extractor (ZHE) was developed. The modified method was demonstrated to be acceptable in a side by side comparison with an EPA recommended ZHE using nonradioactive saltstone containing tetraphenylborate (TPB). TCLP results for all saltstone samples tested containing TPB (both simulant and actual Tank 48H waste) were below the regulatory limit for benzene (0.5 mg/L). In general, higher curing temperatures corresponded to higher concentrations of benzene in TCLP extract. The TCLP performed on the simulant samples cured under the most extreme conditions (3000 mg/L TPB in salt and cured at 95 C for at least 144 days) resulted in benzene values that were greater than half the regulatory limit. Taking into account that benzene in TCLP extract was measured on the same order of magnitude as the regulatory limit, that these experimental conditions may not be representative of actual curing profiles found in the saltstone vault and that there is significant uncertainty associated with the precision of the method, it is recommended that to increase confidence in TCLP results for benzene, the maximum curing temperature of saltstone be less than 95 C. At this time, no further benzene TCLP testing is warranted. Additional verification would be recommended, however, should future processing strategies result in significant changes to salt waste composition in saltstone as factors beyond the scope of this limited study may influence the decomposition of TPB in saltstone.

  4. Resources for global risk assessment: The International Toxicity Estimates for Risk (ITER) and Risk Information Exchange (RiskIE) databases

    SciTech Connect (OSTI)

    Wullenweber, Andrea Kroner, Oliver; Kohrman, Melissa; Maier, Andrew; Dourson, Michael; Rak, Andrew; Wexler, Philip; Tomljanovic, Chuck

    2008-11-15

    The rate of chemical synthesis and use has outpaced the development of risk values and the resolution of risk assessment methodology questions. In addition, available risk values derived by different organizations may vary due to scientific judgments, mission of the organization, or use of more recently published data. Further, each organization derives values for a unique chemical list so it can be challenging to locate data on a given chemical. Two Internet resources are available to address these issues. First, the International Toxicity Estimates for Risk (ITER) database ( (www.tera.org/iter)) provides chronic human health risk assessment data from a variety of organizations worldwide in a side-by-side format, explains differences in risk values derived by different organizations, and links directly to each organization's website for more detailed information. It is also the only database that includes risk information from independent parties whose risk values have undergone independent peer review. Second, the Risk Information Exchange (RiskIE) is a database of in progress chemical risk assessment work, and includes non-chemical information related to human health risk assessment, such as training modules, white papers and risk documents. RiskIE is available at (http://www.allianceforrisk.org/RiskIE.htm), and will join ITER on National Library of Medicine's TOXNET ( (http://toxnet.nlm.nih.gov/)). Together, ITER and RiskIE provide risk assessors essential tools for easily identifying and comparing available risk data, for sharing in progress assessments, and for enhancing interaction among risk assessment groups to decrease duplication of effort and to harmonize risk assessment procedures across organizations.

  5. 2004 Toxic Chemical Release Inventory Report for the Emergency Planning and Community Right-to-Know Act of 1986, Title III, Section 313

    SciTech Connect (OSTI)

    M. Stockton

    2006-01-15

    Section 313 of Emergency Planning and Community Right-to-Know Act (EPCRA) specifically requires facilities to submit a Toxic Chemical Release Inventory Report (Form R) to the U.S. Environmental Protection Agency (EPA) and state agencies if the owners and operators manufacture, process, or otherwise use any of the listed toxic chemicals above listed threshold quantities. EPA compiles this data in the Toxic Release Inventory database. Form R reports for each chemical over threshold quantities must be submitted on or before July 1 each year and must cover activities that occurred at the facility during the previous year. For reporting year 2004, Los Alamos National Laboratory (LANL or the Laboratory) submitted Form R reports for lead compounds, nitric acid, and nitrate compounds as required under the EPCRA Section 313. No other EPCRA Section 313 chemicals were used in 2004 above the reportable thresholds. This document provides a description of the evaluation of EPCRA Section 313 chemical use and threshold determinations for LANL for calendar year 2004, as well as background information about data included on the Form R reports.

  6. Sun light mediated synthesis of gold nanoparticles as carrier for 6-mercaptopurine: Preparation, characterization and toxicity studies in zebrafish embryo model

    SciTech Connect (OSTI)

    Ganeshkumar, Moorthy; Sastry, Thotapalli Parvathaleswara; Sathish Kumar, Muniram; Dinesh, Murugan Girija; Kannappan, Sudalyandi; Suguna, Lonchin

    2012-09-15

    Highlights: ? Gold nanoparticles prepared using eco-friendly method with good in vitro stability. ? Can be used as drug delivery system. ? Did not show any toxicity in zebrafish embryo. ? More toxic to cancer cells when compared to N-Au-Mp and Mp. -- Abstract: The objective of this study is to synthesize green chemistry based gold nanoparticles by sun light irradiation method. The prepared gold nanoparticles (AuNPs) were modified using folic acid and then coupled with 6-mercaptopurine. These modified nanoparticles were used as a tool for targeted drug delivery to treat laryngeal cancer. In the present study, novel bionanocomposites containing nutrient agar coated gold nano particles (N-AuNPs) coupled with 6-mercaptopurine (drug) (N-AuNPs-Mp), folic acid (ligand) (N-AuNPs-Mp-Fa) and rhodamine (dye) (N-AuNPs-Rd), a fluorescent agent, were prepared and characterized by IR, UV, TEM, Particle size analysis and in vitro stability. The toxicity and fluorescence of N-Au was studied using zebrafish embryo model. The in vitro cytotoxicity of free Mp, N-Au-Mp and N-Au-Mp-Fa against HEp-2 cells was compared and found that the amount of Mp required to achieve 50% of growth of inhibition (IC{sub 50}) was much lower in N-Au-Mp-Fa than in free Mp and N-Au-Mp.

  7. Federal program for regulating highly hazardous materials finally takes off

    SciTech Connect (OSTI)

    Lessard, P.C. [Block Environmental Services Inc., Pleasant Hill, CA (United States)

    1996-11-01

    The Risk Management Program (RMP) rule, Section 112(r) of the Clean Air Act (CAA), was signed on May 24 and finalized on June 20. RMP is one of the most comprehensive, technically based regulatory programs for preventing, detecting and responding to accidental hazardous materials releases to have been issued in recent times. Although facilities have three years to comply, EPA estimates that the rule will affect an estimated 66,000 facilities that store highly hazardous or acutely toxic materials. The 1990 CAA Amendments are designed to prevent accidental releases of highly hazardous chemicals from stationary sources. Two significant regulatory programs that have emerged from the revised CAA are the Process Safety Management (PSM) standard and RMP. PSM is designed to protect employees and regulated by the Occupational Safety and Health Administration. RMP`s purpose is to protect the public and the environment from highly hazardous chemicals. It authorizes EPA to create a list of substances (distinct from the list generated under PSM) known to cause serious adverse effects and to implement a program for accidental chemical release prevention.

  8. High Performance Sustainable Building

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2008-06-20

    The guide supports DOE O 413.3A and provides useful information on the incorporation of high performance sustainable building principles into building-related General Plant Projects and Institutional General Plant Projects at DOE sites. Canceled by DOE G 413.3-6A. Does not cancel other directives.

  9. High speed door assembly

    DOE Patents [OSTI]

    Shapiro, C.

    1993-04-27

    A high speed door assembly is described, comprising an actuator cylinder and piston rods, a pressure supply cylinder and fittings, an electrically detonated explosive bolt, a honeycomb structured door, a honeycomb structured decelerator, and a structural steel frame encasing the assembly to close over a 3 foot diameter opening within 50 milliseconds of actuation, to contain hazardous materials and vapors within a test fixture.

  10. High Impact Technology Hub

    Broader source: Energy.gov [DOE]

    The High Impact Technology Hub is a one stop shop for information associated with technology demonstrations in occupied, operational buildings. Resources posted to Hub should accelerate the selection and evaluation of technology demonstration projects and enable transparency into DOEs market stimulation and tech to market activities.

  11. High Power Cryogenic Targets

    SciTech Connect (OSTI)

    Gregory Smith

    2011-08-01

    The development of high power cryogenic targets for use in parity violating electron scattering has been a crucial ingredient in the success of those experiments. As we chase the precision frontier, the demands and requirements for these targets have grown accordingly. We discuss the state of the art, and describe recent developments and strategies in the design of the next generation of these targets.

  12. CSTI high capacity power

    SciTech Connect (OSTI)

    Winter, J.M.

    1994-09-01

    The SP-100 program was established in 1983 by DOD, DOE, and NASA as a joint program to develop the technology necessary for space nuclear power systems for military and civil application. During FY86 and 87, the NASA SP-100 Advanced Technology Program was devised to maintain the momentum of promising technology advancement efforts started during Phase I of SP-100 and to strengthen, in key areas, the chances for successful development and growth capability of space nuclear reactor power systems for future space applications. In FY88, the Advanced Technology Program was incorporated into NASA`s new Civil Space Technology Initiative (CSTI). The CSTI Program was established to provide the foundation for technology development in automation and robotics, information, propulsion, and power. The CSTI High Capacity Power Program builds on the technology efforts of the SP-100 program, incorporates the previous NASA SP-100 Advanced Technology project, and provides a bridge to NASA Project Pathfinder. The elements of CSTI High Capacity Power development include Conversion Systems, Thermal Management, Power Management, System Diagnostics, and Environmental Interactions. Technology advancement in all areas, including materials, is required to assure the high reliability and 7 to 10 year lifetime demanded for future space nuclear power systems. The overall program will develop and demonstrate the technology base required to provide a wide range of modular power systems as well as allowing mission independence from solar and orbital attitude requirements. Several recent advancements in CSTI High Capacity power development will be discussed.

  13. High Temperature ESP Monitoring

    Broader source: Energy.gov [DOE]

    The purpose of the High Temperature ESP Monitoring project is to develop a down-hole monitoring system to be used in wells with bottom hole temperature up to 300 °C for measuring motor temperature; pump discharge pressure; and formation temperature and pressure.

  14. Highly oxidized superconductors

    DOE Patents [OSTI]

    Morris, Donald E. (Kensington, CA)

    1994-01-01

    Novel superconducting materials in the form of compounds, structures or phases are formed by performing otherwise known syntheses in a highly oxidizing atmosphere rather than that created by molecular oxygen at atmospheric pressure or below. This leads to the successful synthesis of novel superconducting compounds which are thermodynamically stable at the conditions under which they are formed.

  15. Highly oxidized superconductors

    DOE Patents [OSTI]

    Morris, D.E.

    1994-09-20

    Novel superconducting materials in the form of compounds, structures or phases are formed by performing otherwise known synthesis in a highly oxidizing atmosphere rather than that created by molecular oxygen at atmospheric pressure or below. This leads to the successful synthesis of novel superconducting compounds which are thermodynamically stable at the conditions under which they are formed. 16 figs.

  16. High expression Zymomonas promoters

    DOE Patents [OSTI]

    Viitanen, Paul V.; Tao, Luan; Zhang, Yuying; Caimi, Perry G.; McCole, Laura : Zhang, Min; Chou, Yat-Chen; McCutchen, Carol M.; Franden, Mary Ann

    2011-08-02

    Identified are mutants of the promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene, which direct improved expression levels of operably linked heterologous nucleic acids. These are high expression promoters useful for expression of chimeric genes in Zymomonas, Zymobacter, and other related bacteria.

  17. Thermoelectrics Partnership: High Performance Thermoelectric...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Performance Thermoelectric Waste Heat Recovery System Based on Zintl Phase Materials with Embedded Nanoparticles Thermoelectrics Partnership: High Performance Thermoelectric...

  18. High Selectivity Oxygen Delignification

    SciTech Connect (OSTI)

    Arthur J. Ragauskas Lucian A. Lucia Hasan Jameel

    2005-09-30

    The overall objective of this program was to develop improved extended oxygen delignification (EOD) technologies for current U.S. pulp mill operations. This was accomplished by: (1) Identifying pulping conditions that optimize O and OO performance; (2) Identifying structural features of lignin that enhance reactivity towards EOD of high kappa pulps; (3) Identifying factors minimizing carbohydrate degradation and improve pulp strength of EOD high kappa pulps; (4) Developing a simple, reproducible method of quantifying yield gains from EOD; and (5) Developing process conditions that significantly reduce the capital requirements of EOD while optimizing the yield benefits. Key research outcomes included, demonstrating the use of a mini-O sequence such as (E+O)Dkf:0.05(E+O) or Dkf:0.05(E+O)(E+O) without interstage washing could capture approximately 60% of the delignification efficiency of a conventional O-stage without the major capital requirements associated with an O-stage for conventional SW kraft pulps. The rate of formation and loss of fiber charge during an O-stage stage can be employed to maximize net fiber charge. Optimal fiber charge development and delignification are two independent parameters and do not parallel each other. It is possible to utilize an O-stage to enhance overall cellulosic fiber charge of low and high kappa SW kraft pulps which is beneficial for physical strength properties. The application of NIR and multi-variant analysis was developed into a rapid and simple method of determining the yield of pulp from an oxygen delignification stage that has real-world mill applications. A focus point of this program was the demonstration that Kraft pulping conditions and oxygen delignification of high and low-kappa SW and HW pulps are intimately related. Improved physical pulp properties and yield can be delivered by controlling the H-factor and active alkali charge. Low AA softwood kraft pulp with a kappa number 30 has an average improvement of 2% in yield and 4 cP in viscosity in comparison to high AA pulp for the oxygen delignification. This difference is also seen for high-kappa SW kraft pulps with an average improvement of {approx}3% in yield and 3 cP in viscosity for low AA high kappa number 50 pulp. Low AA hardwood kappa number 20 pulp had an average improvement of {approx}4% in yield and 6-12 cP in viscosity as compared to high AA pulp. Lower kraft cooking temperature (160 vs. 170 C) in combination with the medium AA provides a practical approach for integrating high kappa pulping of hardwoods (i.e., low rejects) with an advanced extended oxygen delignification stage. ECF pulp bleaching of low and high kappa kraft SW and HW pulps exhibit comparable optical and physical strength properties when bleached D(EPO)D.

  19. Apparatus and method for enhanced chemical processing in high pressure and atmospheric plasmas produced by high frequency electromagnetic waves

    DOE Patents [OSTI]

    Efthimion, Philip C. (Bedminister, NJ); Helfritch, Dennis J. (Flemington, NJ)

    1989-11-28

    An apparatus and method for creating high temperature plasmas for enhanced chemical processing of gaseous fluids, toxic chemicals, and the like, at a wide range of pressures, especially at atmospheric and high pressures includes an electro-magnetic resonator cavity, preferably a reentrant cavity, and a wave guiding structure which connects an electro-magnetic source to the cavity. The cavity includes an intake port and an exhaust port, each having apertures in the conductive walls of the cavity sufficient for the intake of the gaseous fluids and for the discharge of the processed gaseous fluids. The apertures are sufficiently small to prevent the leakage of the electro-magnetic radiation from the cavity. Gaseous fluid flowing from the direction of the electro-magnetic source through the guiding wave structure and into the cavity acts on the plasma to push it away from the guiding wave structure and the electro-magnetic source. The gaseous fluid flow confines the high temperature plasma inside the cavity and allows complete chemical processing of the gaseous fluids at a wide range of pressures.

  20. Fast high-temperature superconductor switch for high current applications

    Office of Scientific and Technical Information (OSTI)

    (Journal Article) | SciTech Connect Fast high-temperature superconductor switch for high current applications Citation Details In-Document Search Title: Fast high-temperature superconductor switch for high current applications Reversible operation of a high current superconductor switch based on the quench of high-resistance second generation high temperature superconducting wire is demonstrated. The quench is induced by a burst of an ac field generated by an inductively coupled

  1. High Titer and Yields Achieved with Novel, Low-Severity Pretreatment Strategy (Fact Sheet), Highlights in Research & Development, NREL (National Renewable Energy Laboratory)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A new, less toxic, NREL-developed deacetylation and mechanical refining (DMR) process achieves unexpectedly high sugar titers and yields for fermentation into advanced biofuels and chemicals. Reducing biomass resistance to deconstruction of its biopolymers to fermentable and catalyti- cally upgradeable sugars and lignin monomers with various thermal, chemical, and mechanical treatments has been a focus of intense research for the past century. However, most of the pretreatment methods utilize

  2. High-performance steels

    SciTech Connect (OSTI)

    Barsom, J.M.

    1996-03-01

    Steel is the material of choice in structures such as storage tanks, gas and oil distribution pipelines, high-rise buildings, and bridges because of its strength, ductility, and fracture toughness, as well as its repairability and recyclability. Furthermore, these properties are continually being improved via advances in steelmaking, casting, rolling, and chemistry. Developments in steelmaking have led to alloys having low sulfur, sulfide shape control, and low hydrogen. They provide reduced chemical segregation, higher fracture toughness, better through-thickness and weld heat-affected zone properties, and lower susceptibility to hydrogen cracking. Processing has moved beyond traditional practices to designed combinations of controlled rolling and cooling known as thermomechanical control processes (TMCP). In fact, chemical composition control and TMCP now enable such precise adjustment of final properties that these alloys are now known as high-performance steels (HPS), engineered materials having properties tailored for specific applications.

  3. High frequency reference electrode

    DOE Patents [OSTI]

    Kronberg, J.W.

    1994-05-31

    A high frequency reference electrode for electrochemical experiments comprises a mercury-calomel or silver-silver chloride reference electrode with a layer of platinum around it and a layer of a chemically and electrically resistant material such as TEFLON around the platinum covering all but a small ring or halo' at the tip of the reference electrode, adjacent to the active portion of the reference electrode. The voltage output of the platinum layer, which serves as a redox electrode, and that of the reference electrode are coupled by a capacitor or a set of capacitors and the coupled output transmitted to a standard laboratory potentiostat. The platinum may be applied by thermal decomposition to the surface of the reference electrode. The electrode provides superior high-frequency response over conventional electrodes. 4 figs.

  4. High frequency reference electrode

    DOE Patents [OSTI]

    Kronberg, James W.

    1994-01-01

    A high frequency reference electrode for electrochemical experiments comprises a mercury-calomel or silver-silver chloride reference electrode with a layer of platinum around it and a layer of a chemically and electrically resistant material such as TEFLON around the platinum covering all but a small ring or "halo" at the tip of the reference electrode, adjacent to the active portion of the reference electrode. The voltage output of the platinum layer, which serves as a redox electrode, and that of the reference electrode are coupled by a capacitor or a set of capacitors and the coupled output transmitted to a standard laboratory potentiostat. The platinum may be applied by thermal decomposition to the surface of the reference electrode. The electrode provides superior high-frequency response over conventional electrodes.

  5. High Temperature ESP Monitoring

    SciTech Connect (OSTI)

    Jack Booker; Brindesh Dhruva

    2011-06-20

    The objective of the High Temperature ESP Monitoring project was to develop a downhole monitoring system to be used in wells with bottom hole well temperatures up to 300C for measuring motor temperature, formation pressure, and formation temperature. These measurements are used to monitor the health of the ESP motor, to track the downhole operating conditions, and to optimize the pump operation. A 220 C based High Temperature ESP Monitoring system was commercially released for sale with Schlumberger ESP motors April of 2011 and a 250 C system with will be commercially released at the end of Q2 2011. The measurement system is now fully qualified, except for the sensor, at 300 C.

  6. High temperature probe

    DOE Patents [OSTI]

    Swan, Raymond A.

    1994-01-01

    A high temperature probe for sampling, for example, smokestack fumes, and is able to withstand temperatures of 3000.degree. F. The probe is constructed so as to prevent leakage via the seal by placing the seal inside the water jacket whereby the seal is not exposed to high temperature, which destroys the seal. The sample inlet of the probe is also provided with cooling fins about the area of the seal to provide additional cooling to prevent the seal from being destroyed. Also, a heated jacket is provided for maintaining the temperature of the gas being tested as it passes through the probe. The probe includes pressure sensing means for determining the flow velocity of an efficient being sampled. In addition, thermocouples are located in various places on the probe to monitor the temperature of the gas passing there through.

  7. High temperature measuring device

    DOE Patents [OSTI]

    Tokarz, Richard D.

    1983-01-01

    A temperature measuring device for very high design temperatures (to 2,000.degree. C.). The device comprises a homogenous base structure preferably in the form of a sphere or cylinder. The base structure contains a large number of individual walled cells. The base structure has a decreasing coefficient of elasticity within the temperature range being monitored. A predetermined quantity of inert gas is confined within each cell. The cells are dimensionally stable at the normal working temperature of the device. Increases in gaseous pressure within the cells will permanently deform the cell walls at temperatures within the high temperature range to be measured. Such deformation can be correlated to temperature by calibrating similarly constructed devices under known time and temperature conditions.

  8. Imprint-coating synthesis of selective functionalized ordered mesoporous sorbents for separation and sensors

    DOE Patents [OSTI]

    Dai, Sheng (Knoxville, TN); Burleigh, Mark C. (Lenoir City, TN); Shin, Yongsoon (Richland, WA)

    2001-01-01

    The present invention relates generally to mesoporous sorbent materials having high capacity, high selectivity, fast kinetics, and molecular recognition capability. The invention also relates to a process for preparing these mesoporous substrates through molecular imprinting techniques which differ from convention techniques in that a template molecule is bound to one end of bifunctional ligands to form a complex prior to binding of the bifunctional ligands to the substrate. The present invention also relates to methods of using the mesoporous sorbent materials, for example, in the separation of toxic metals from process effluents, paints, and other samples; detection of target molecules, such as amino acids, drugs, herbicides, fertilizers, and TNT, in samples; separation and/or detection of substances using chromatography; imaging agents; sensors; coatings; and composites.

  9. High efficiency gas burner

    DOE Patents [OSTI]

    Schuetz, Mark A. (Belmont, MA)

    1983-01-01

    A burner assembly provides for 100% premixing of fuel and air by drawing the air into at least one high velocity stream of fuel without power assist. Specifically, the nozzle assembly for injecting the fuel into a throat comprises a plurality of nozzles in a generally circular array. Preferably, swirl is imparted to the air/fuel mixture by angling the nozzles. The diffuser comprises a conical primary diffuser followed by a cusp diffuser.

  10. High-speed

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    speed three-wave polarimeter-interferometer diagnostic for Madison symmetric torus B. H. Deng, D. L. Brower, and W. X. Ding Electrical Engineering Department, University of California, Los Angeles, California 90095 M. D. Wyman, B. E. Chapman, and J. S. Sarff Department of Physics, University of Wisconsin, Madison, Wisconsin 53706 ͑Received 5 May 2006; presented on 10 May 2006; accepted 11 June 2006; published online 27 September 2006͒ A high-speed three-wave polarimeter-interferometer

  11. High current ion source

    DOE Patents [OSTI]

    Brown, Ian G. (1088 Woodside Rd., Berkeley, CA 94708); MacGill, Robert A. (645 Kern St., Richmond, CA 94805); Galvin, James E. (2 Commodore Dr. #276, Emeryville, CA 94608)

    1990-01-01

    An ion source utilizing a cathode and anode for producing an electric arc therebetween. The arc is sufficient to vaporize a portion of the cathode to form a plasma. The plasma leaves the generation region and expands through another regon. The density profile of the plasma may be flattened using a magnetic field formed within a vacuum chamber. Ions are extracted from the plasma to produce a high current broad on beam.

  12. high renewable energy penetration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    high renewable energy penetration - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Fuel Cycle Defense Waste Management Programs

  13. high-power LEDs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    high-power LEDs - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Fuel Cycle Defense Waste Management Programs Advanced Nuclear

  14. High Performance Window Attachments

    Energy Savers [EERE]

    High Performance Window Attachments D. Charlie Curcija Lawrence Berkeley National Laboratory dccurcija@lbl.gov 510-495-2602 April 4, 2013 2 | Building Technologies Office eere.energy.gov Purpose & Objectives Impact of Project: * Motivate manufacturers to make improvements in Window systems U-Factors, SHGC and daylighting utilization * Increase awareness of benefits from energy efficient window attachments Problem Statement: * A wide range of residential window attachments are available, but

  15. High voltage pulse conditioning

    DOE Patents [OSTI]

    Springfield, Ray M. (Sante Fe, NM); Wheat, Jr., Robert M. (Los Alamos, NM)

    1990-01-01

    Apparatus for conditioning high voltage pulses from particle accelerators in order to shorten the rise times of the pulses. Flashover switches in the cathode stalk of the transmission line hold off conduction for a determinable period of time, reflecting the early portion of the pulses. Diodes upstream of the switches divert energy into the magnetic and electrostatic storage of the capacitance and inductance inherent to the transmission line until the switches close.

  16. High Energy Density Microwaves

    SciTech Connect (OSTI)

    Phillips, R.M. [Stanford Linear Accelerator Center, Stanford, CA 94309 (United States)

    1999-04-01

    These proceedings represent papers presented at the RF98 Workshop entitled `High Energy Density Microwaves` held in California in October, 1998. The topics discussed were predominantly accelerator{minus}related. The Workshop dealt, for the most part, with the generation and control of electron beams, the amplification of RF signals, the design of mode converters, and the effect of very high RF field gradients. This Workshop was designed to address the concerns of the microwave tube industry worldwide, the plasma physicists who deal with very high beam currents and gigawatts of RF power, and researchers in accelerator centers around the world. Papers were presented on multibeam klystrons, gyrotron development, plasmas in microwave tubes, RF breakdown, and alternatives to conventional linear coliders at 1 TeV and above. The Workshop was partially sponsored by the US Department of Energy. There were 46 papers presented at the conference,out of which 19 have been abstracted for the Energy,Science and Technology database.(AIP)

  17. High pressure ceramic joint

    DOE Patents [OSTI]

    Ward, Michael E. (Poway, CA); Harkins, Bruce D. (San Diego, CA)

    1993-01-01

    Many recuperators have components which react to corrosive gases and are used in applications where the donor fluid includes highly corrosive gases. These recuperators have suffered reduced life, increased service or maintenance, and resulted in increased cost. The present joint when used with recuperators increases the use of ceramic components which do not react to highly corrosive gases. Thus, the present joint used with the present recuperator increases the life, reduces the service and maintenance, and reduces the increased cost associated with corrosive action of components used to manufacture recuperators. The present joint is comprised of a first ceramic member, a second ceramic member, a mechanical locking device having a groove defined in one of the first ceramic member and the second ceramic member. The joint and the mechanical locking device is further comprised of a refractory material disposed in the groove and contacting the first ceramic member and the second ceramic member. The present joint mechanically provides a high strength load bearing joint having good thermal cycling characteristics, good resistance to a corrosive environment and good steady state strength at elevated temperatures.

  18. High pressure ceramic joint

    DOE Patents [OSTI]

    Ward, M.E.; Harkins, B.D.

    1993-11-30

    Many recuperators have components which react to corrosive gases and are used in applications where the donor fluid includes highly corrosive gases. These recuperators have suffered reduced life, increased service or maintenance, and resulted in increased cost. The present joint when used with recuperators increases the use of ceramic components which do not react to highly corrosive gases. Thus, the present joint used with the present recuperator increases the life, reduces the service and maintenance, and reduces the increased cost associated with corrosive action of components used to manufacture recuperators. The present joint is comprised of a first ceramic member, a second ceramic member, a mechanical locking device having a groove defined in one of the first ceramic member and the second ceramic member. The joint and the mechanical locking device is further comprised of a refractory material disposed in the groove and contacting the first ceramic member and the second ceramic member. The present joint mechanically provides a high strength load bearing joint having good thermal cycling characteristics, good resistance to a corrosive environment and good steady state strength at elevated temperatures. 4 figures.

  19. High energy physics

    SciTech Connect (OSTI)

    Kernan, A.; Shen, B.C.; Ma, E.

    1997-07-01

    This proposal is for the continuation of the High Energy Physics program at the University of California at Riverside. In hadron collider physics the authors will complete their transition from experiment UA1 at CERN to the DZERO experiment at Fermilab. On experiment UA1 their effort will concentrate on data analysis at Riverside. At Fermilab they will coordinate the high voltage system for all detector elements. They will also carry out hardware/software development for the D0 muon detector. The TPC/Two-Gamma experiment has completed its present phase of data-taking after accumulating 160 pb{sup {minus}}1 of luminosity. The UC Riverside group will continue data and physics analysis and make minor hardware improvement for the high luminosity run. The UC Riverside group is participating in design and implementation of the data acquisition system for the OPAL experiment at LEP. Mechanical and electronics construction of the OPAL hadron calorimeter strip readout system is proceeding on schedule. Data analysis and Monte Carlo detector simulation efforts are proceeding in preparation for the first physics run when IEP operation comenses in fall 1989.

  20. High temperature interfacial superconductivity

    DOE Patents [OSTI]

    Bozovic, Ivan (Mount Sinai, NY); Logvenov, Gennady (Port Jefferson Station, NY); Gozar, Adrian Mihai (Port Jefferson, NY)

    2012-06-19

    High-temperature superconductivity confined to nanometer-scale interfaces has been a long standing goal because of potential applications in electronic devices. The spontaneous formation of a superconducting interface in bilayers consisting of an insulator (La.sub.2CuO.sub.4) and a metal (La.sub.1-xSr.sub.xCuO.sub.4), neither of which is superconducting per se, is described. Depending upon the layering sequence of the bilayers, T.sub.c may be either .about.15 K or .about.30 K. This highly robust phenomenon is confined to within 2-3 nm around the interface. After exposing the bilayer to ozone, T.sub.c exceeds 50 K and this enhanced superconductivity is also shown to originate from a 1 to 2 unit cell thick interfacial layer. The results demonstrate that engineering artificial heterostructures provides a novel, unconventional way to fabricate stable, quasi two-dimensional high T.sub.c phases and to significantly enhance superconducting properties in other superconductors. The superconducting interface may be implemented, for example, in SIS tunnel junctions or a SuFET.

  1. Preparation of highly luminescent and color tunable carbon nanodots under visible light excitation for in vitro and in vivo bio-imaging

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Zheng, Min; Li, Jing; Xie, Zhigang; Qu, Dan; Miao, Xiang; Jing, Xiabing; Sun, Zaicheng; Fan, Hongyou; Liu, Shi

    2015-11-10

    Carbon nanodots (CDs) have generated enormous excitement because of their superiority in water solubility, chemical inertness, low toxicity, ease of functionalization and resistance to photobleaching. Here we report a facile thermal pyrolysis route to prepare CDs with high quantum yield (QY) using citric acid as the carbon source and ethylene diamine derivatives (EDAs) including triethylenetetramine (TETA), tetraethylenepentamine (TEPA) and polyene polyamine (PEPA) as the passivation agents. We find that the CDs prepared from EDAs, such as TETA, TEPA and PEPA, show relatively high photoluminescence (PL) QY (11.4, 10.6, and 9.8%, respectively) at 1ex of 465 nm. The cytotoxicity of themore » CDs has been investigated through in vitro and in vivo bio-imaging studies. The results indicate that these CDs possess low toxicity and good biocompatibility. As a result, the unique properties such as the high PL QY at large excitation wave length and the low toxicity of the resulting CDs make them promising fluorescent nanoprobes for applications in optical bio-imaging and biosensing.« less

  2. HIGH EFFICIENCY SYNGAS GENERATION

    SciTech Connect (OSTI)

    Robert J. Copeland; Yevgenia Gershanovich; Brian Windecker

    2005-02-01

    This project investigated an efficient and low cost method of auto-thermally reforming natural gas to hydrogen and carbon monoxide. Reforming is the highest cost step in producing products such as methanol and Fisher Tropsch liquids (i.e., gas to liquids); and reducing the cost of reforming is the key to reducing the cost of these products. Steam reforming is expensive because of the high cost of the high nickel alloy reforming tubes (i.e., indirectly fired reforming tubes). Conventional auto-thermal or Partial Oxidation (POX) reforming minimizes the size and cost of the reformers and provides a near optimum mixture of CO and hydrogen. However POX requires pure oxygen, which consumes power and significantly increases the cost to reforming. Our high efficiency process extracts oxygen from low-pressure air with novel oxygen sorbent and transfers the oxygen to a nickel-catalyzed reformer. The syngas is generated at process pressure (typically 20 to 40 bar) without nitrogen dilution and has a 1CO to 2H{sub 2} ratio that is near optimum for the subsequent production of Fisher-Tropsch liquid to liquids and other chemicals (i.e., Gas to Liquids, GTL). Our high process efficiency comes from the way we transfer the oxygen into the reformer. All of the components of the process, except for the oxygen sorbent, are commonly used in commercial practice. A process based on a longlived, regenerable, oxygen transfer sorbent could substantially reduce the cost of natural gas reforming to syngas. Lower cost syngas (CO + 2H{sub 2}) that is the feedstock for GTL would reduce the cost of GTL and for other commercial applications (e.g., methanol, other organic chemicals). The vast gas resources of Alaska's North Slope (ANS) offer more than 22 Tcf of gas and GTL production in this application alone, and could account for as much as 300,000 to 700,000 bpd for 20 to 30+ years. We developed a new sorbent, which is an essential part of the High Efficiency Oxygen Process (HOP). We tested the sorbent and observed that it has both a good oxygen capacity and operates as a highly effective reforming catalyst. We conducted a long duration tests of the sorbent (1,500 hours of continuous operation in the HOP cycle). Although the sorbent lost some oxygen capacity with cycling, the sorbent oxygen capacity stabilized after 1,000 hours and remained constant to the end of the test, 1,500 hour. The activity of the catalyst to reform methane to a hydrogen and carbon monoxide mixture was unchanged through the oxidation/reduction cycling. Our cost and performance analyses indicated a significant reduction in the cost of GTL production when using the HOP process integrated into a GTL plant.

  3. High efficiency photoionization detector

    DOE Patents [OSTI]

    Anderson, D.F.

    1984-01-31

    A high efficiency photoionization detector is described using tetraaminoethylenes in a gaseous state having a low ionization potential and a relative photoionization cross section which closely matches the emission spectrum of xenon gas. Imaging proportional counters are also disclosed using the novel photoionization detector of the invention. The compound of greatest interest is TMAE which comprises tetrakis(dimethylamino)ethylene which has a measured ionization potential of 5.36 [+-] 0.02 eV, and a vapor pressure of 0.35 torr at 20 C. 6 figs.

  4. High temperature detonator

    DOE Patents [OSTI]

    Johnson, James O. (Los Alamos, NM); Dinegar, Robert H. (Los Alamos, NM)

    1988-01-01

    A detonator assembly is provided which is usable at high temperatures about 300.degree. C. A detonator body is provided with an internal volume defining an anvil surface. A first acceptor explosive is disposed on the anvil surface. A donor assembly having an ignition element, an explosive material, and a flying plate, are placed in the body effective to accelerate the flying plate to impact the first acceptor explosive on the anvil for detonating the first acceptor explosive. A second acceptor explosive is eccentrically located in detonation relationship with the first acceptor explosive to thereafter effect detonation of a main charge.

  5. High Tc Superconductivity

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    by C. Kim (SSRL), D. H. Lu (Stanford), K. M. Shen (Stanford) and Z.-X. Shen (Stanford/SSRL) Extensive research efforts to study the novel electronic properties of high-Tc superconductors and their related materials by angle-resolved photoemission spectroscopy at a recently commissioned Beam Line 5-4 (led by Z.-X. Shen) continue to be successful, producing many important results. These results, which are highlighted by five articles recently published in Physical Review Letters and one in

  6. Manufacturing High Temperature Systems

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Manufacturing and Scale Up Challenges Joseph Hartvigsen Ceramatec, Inc. National Renewable Energy Laboratory Golden, CO February 28, 2014 Antipode Assertions * Electric power generation is not the limitation - To misquote Jay Leno "Use all you want, we'll make more" - http://atomicinsights.com/2013/02/use-all-the-electricity-you-want-well-make-more.html * High electric costs come from working the demand curve from below rather than above * "Grid Storage" is a misleading

  7. Theoretical High Energy Physics

    SciTech Connect (OSTI)

    Christ, Norman H.; Weinberg, Erick J.

    2014-07-14

    we provide reports from each of the six faculty supported by the Department of Energy High Energy Physics Theory grant at Columbia University. Each is followed by a bibliography of the references cited. A complete list of all of the publications in the 12/1/2010-04/30/2014 period resulting from research supported by this grant is provided in the following section. The final section lists the Ph.D. dissertations based on research supported by the grant that were submitted during this period.

  8. High Energy QCD

    SciTech Connect (OSTI)

    Yuri Kovchegov

    2012-05-31

    The project significantly advanced our understanding of the theory of strong interactions known as quantum chromodynamics (QCD) in high energy collisions of elementary particles and nuclei. QCD is one of the four fundamental forces of nature, but is understood quite poorly due to the complexity of strong interactions. This project advanced our understanding of QCD in the very high energy collisions of protons and nuclei, where densities of quarks and gluons inside the colliding particles are so high (due to high energy) that complicated nonlinear interactions between quarks and gluons become important. This regime is known as gluon (or parton) saturation. The result of the project is a significant improvement of our understanding of the physics of gluon saturation: important (running coupling) corrections to the existing description of the process (the so-called Balitsky-Kovchegov equation) have been calculated, placing the BK equation in good agreement with the experimental data on deep inelastic scattering (DIS), a process where an electron is collided with the proton to probe the proton's internal structure. Corresponding cross section for quark and gluon production in DIS and nuclear collisions have been calculated and corrected correspondingly, resulting in new and interesting predictions for the physics to be probed in heavy ion collisions at the Large Hadron Collider (LHC). The dense gluon systems play an important role in collisions of ultrarelativistic large nuclei, which are performed in order to create a plasma of quarks and gluons (QGP). An important question in the field is how exactly this QGP is produced in a collision of two heavy ions. The conclusion of this project is that QGP production happens due to strong coupling effects between quarks and gluons. This made theoretical description of QGP production only possible using the methods emerging from string theory. Using these methods QGP production was well understood as a result of this project. The project was mainly accomplished by analytic calculations, with occasional use of personal computers and a supercomputer to perform numerical calculations. As such it is very economic and technically effective. The benefit to public is by broadening our understanding of fundamental physics. Strong interactions are responsible for about 98$\\%$ of the visible mass in the Universe, and their understanding is vital both for understanding how the Universe works and for which physics lies beyond the known interactions of Standard Model of particle physics.

  9. High flux reactor

    DOE Patents [OSTI]

    Lake, James A.; Heath, Russell L.; Liebenthal, John L.; DeBoisblanc, Deslonde R.; Leyse, Carl F.; Parsons, Kent; Ryskamp, John M.; Wadkins, Robert P.; Harker, Yale D.; Fillmore, Gary N.; Oh, Chang H.

    1988-01-01

    A high flux reactor is comprised of a core which is divided into two symetric segments housed in a pressure vessel. The core segments include at least one radial fuel plate. The spacing between the plates functions as a coolant flow channel. The core segments are spaced axially apart such that a coolant mixing plenum is formed between them. A channel is provided such that a portion of the coolant bypasses the first core section and goes directly into the mixing plenum. The outlet coolant from the first core segment is mixed with the bypass coolant resulting in a lower inlet temperature to the lower core segment.

  10. High speed flywheel

    DOE Patents [OSTI]

    McGrath, Stephen V. (Knoxville, TN)

    1991-01-01

    A flywheel for operation at high speeds utilizes two or more ringlike coments arranged in a spaced concentric relationship for rotation about an axis and an expansion device interposed between the components for accommodating radial growth of the components resulting from flywheel operation. The expansion device engages both of the ringlike components, and the structure of the expansion device ensures that it maintains its engagement with the components. In addition to its expansion-accommodating capacity, the expansion device also maintains flywheel stiffness during flywheel operation.

  11. High power microwave generator

    DOE Patents [OSTI]

    Minich, Roger W. (Patterson, CA)

    1988-01-01

    A device (10) for producing high-powered and coherent microwaves is described. The device comprises an evacuated, cylindrical, and hollow real cathode (20) that is driven to inwardly field emit relativistic electrons. The electrons pass through an internally disposed cylindrical and substantially electron-transparent cylindrical anode (24), proceed toward a cylindrical electron collector electrode (26), and form a cylindrical virtual cathode (32). Microwaves are produced by spatial and temporal oscillations of the cylindrical virtual cathode (32), and by electrons that reflex back and forth between the cylindrical virtual cathode (32) and the cylindrical real cathode (20).

  12. High efficiency photoionization detector

    DOE Patents [OSTI]

    Anderson, David F.

    1984-01-01

    A high efficiency photoionization detector using tetraaminoethylenes in a gaseous state having a low ionization potential and a relative photoionization cross section which closely matches the emission spectrum of xenon gas. Imaging proportional counters are also disclosed using the novel photoionization detector of the invention. The compound of greatest interest is TMAE which comprises tetrakis(dimethylamino)ethylene which has a measured ionization potential of 5.36.+-.0.02 eV, and a vapor pressure of 0.35 torr at 20.degree. C.

  13. High-nitrogen explosives

    SciTech Connect (OSTI)

    Naud, D.; Hiskey, M. A.; Kramer, J. F.; Bishop, R. L.; Harry, H. H.; Son, S. F.; Sullivan, G. K.

    2002-01-01

    The syntheses and characterization of various tetrazine and furazan compounds offer a different approach to explosives development. Traditional explosives - such as TNT or RDX - rely on the oxidation of the carbon and hydrogen atoms by the oxygen carrying nitro group to produce the explosive energy. High-nitrogen compounds rely instead on large positive heats of formation for that energy. Some of these high-nitrogen compounds have been shown to be less sensitive to initiation (e.g. by impact) when compared to traditional nitro-containing explosives of similar performances. Using the precursor, 3,6-bis-(3,5-dimethylpyrazol-1-yl)-s-tetrazine (BDT), several useful energetic compounds based on the s-tetrazine system have been synthesized and studied. The compound, 3,3{prime}-azobis(6-amino-s-tetrazine) or DAAT, detonates as a half inch rate stick despite having no oxygen in the molecule. Using perfluoroacetic acid, DAAT can be oxidized to give mixtures of N-oxide isomers (DAAT03.5) with an average oxygen content of about 3.5. This energetic mixture burns at extremely high rates and with low dependency on pressure. Another tetrazine compound of interest is 3,6-diguanidino-s-tetrazine(DGT) and its dinitrate and diperchlorate salts. DGT is easily synthesized by reacting BDT with guanidine in methanol. Using Caro's acid, DGT can be further oxidized to give 3,6-diguanidino-s-tetrazine-1,4-di-N-oxide (DGT-DO). Like DGT, the di-N-oxide can react with nitric acid or perchloric acid to give the dinitrate and the diperchlorate salts. The compounds, 4,4{prime}-diamino-3,3{prime}-azoxyfurazan (DAAF) and 4,4{prime}-diamino-3,3{prime}-azofurazan (DAAzF), may have important future roles in insensitive explosive applications. Neither DAAF nor DAAzF can be initiated by laboratory impact drop tests, yet both have in some aspects better explosive performances than 1,3,5-triamino-2,4,6-trinitrobenzene TATB - the standard of insensitive high explosives. The thermal stability of DAAzF is equal to that of hexanitrostilbene (HNS), yet it has a greater CJ pressure and detonation velocity. In an effort to reduce the critical diameter of TATB without sacrificing its insensitivity, we have studied the explosive performances of TATB mixed with DAAzlF (X-0561) and TATB mixed with DAAF (X-0563).

  14. High Risk Plan

    Office of Environmental Management (EM)

    Risk Plan John Bashista Melissa Rider Jeff Davis Timeline to date * OMB memo on Improving Government Acquisition issued July 29, 2009 - Review existing contracts and acquisition practices to save 7% of baseline contract spending (3.5% in FY 2010 and 3.5% in FY 2011) - Reduce high risk contracts by 10% the share of dollars obligated in FY2010 - Final plan was due and submitted on November 2, 2009 - OMB reviewed and requested revision Dec 23, 2009 - Revision submitted April 21, 2010 M&Os are

  15. High Temperature, High Voltage Fully Integrated Gate Driver Circuit...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    -- Washington D.C. PDF icon ape03marlino.pdf More Documents & Publications High Temperature, High Voltage Fully Integrated Gate Driver Circuit Smart Integrated Power Module ...

  16. High Temperature, High Voltage Fully Integrated Gate Driver Circuit...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    D.C. PDF icon ape003tolbert2010p.pdf More Documents & Publications High Temperature, High Voltage Fully Integrated Gate Driver Circuit Wide Bandgap Materials Smart ...

  17. High speed transient sampler

    DOE Patents [OSTI]

    McEwan, Thomas E. (Livermore, CA)

    1995-01-01

    A high speed sampler comprises a meandered sample transmission line for transmitting an input signal, a straight strobe transmission line for transmitting a strobe signal, and a plurality of sampling gates along the transmission lines. The sampling gates comprise a four terminal diode bridge having a first strobe resistor connected from a first terminal of the bridge to the positive strobe line, a second strobe resistor coupled from the third terminal of the bridge to the negative strobe line, a tap connected to the second terminal of the bridge and to the sample transmission line, and a sample holding capacitor connected to the fourth terminal of the bridge. The resistance of the first and second strobe resistors is much higher than the signal transmission line impedance in the preferred system. This results in a sampling gate which applies a very small load on the sample transmission line and on the strobe generator. The sample holding capacitor is implemented using a smaller capacitor and a larger capacitor isolated from the smaller capacitor by resistance. The high speed sampler of the present invention is also characterized by other optimizations, including transmission line tap compensation, stepped impedance strobe line, a multi-layer physical layout, and unique strobe generator design. A plurality of banks of such samplers are controlled for concatenated or interleaved sample intervals to achieve long sample lengths or short sample spacing.

  18. High speed transient sampler

    DOE Patents [OSTI]

    McEwan, T.E.

    1995-11-28

    A high speed sampler comprises a meandered sample transmission line for transmitting an input signal, a straight strobe transmission line for transmitting a strobe signal, and a plurality of sampling gates along the transmission lines. The sampling gates comprise a four terminal diode bridge having a first strobe resistor connected from a first terminal of the bridge to the positive strobe line, a second strobe resistor coupled from the third terminal of the bridge to the negative strobe line, a tap connected to the second terminal of the bridge and to the sample transmission line, and a sample holding capacitor connected to the fourth terminal of the bridge. The resistance of the first and second strobe resistors is much higher than the signal transmission line impedance in the preferred system. This results in a sampling gate which applies a very small load on the sample transmission line and on the strobe generator. The sample holding capacitor is implemented using a smaller capacitor and a larger capacitor isolated from the smaller capacitor by resistance. The high speed sampler of the present invention is also characterized by other optimizations, including transmission line tap compensation, stepped impedance strobe line, a multi-layer physical layout, and unique strobe generator design. A plurality of banks of such samplers are controlled for concatenated or interleaved sample intervals to achieve long sample lengths or short sample spacing. 17 figs.

  19. High temperature thermometric phosphors

    DOE Patents [OSTI]

    Allison, S.W.; Cates, M.R.; Boatner, L.A.; Gillies, G.T.

    1999-03-23

    A high temperature phosphor consists essentially of a material having the general formula LuPO{sub 4}:Dy{sub x},Eu{sub y} wherein: 0.1 wt % {<=} x {<=} 20 wt % and 0.1 wt % {<=} y {<=} 20 wt %. The high temperature phosphor is in contact with an article whose temperature is to be determined. The article having the phosphor in contact with it is placed in the environment for which the temperature of the article is to be determined. The phosphor is excited by a laser causing the phosphor to fluoresce. The emission from the phosphor is optically focused into a beam-splitting mirror which separates the emission into two separate emissions, the emission caused by the dysprosium dopant and the emission caused by the europium dopant. The separated emissions are optically filtered and the intensities of the emission are detected and measured. The ratio of the intensity of each emission is determined and the temperature of the article is calculated from the ratio of the intensities of the separate emissions. 2 figs.

  20. High temperature thermometric phosphors

    DOE Patents [OSTI]

    Allison, Stephen W.; Cates, Michael R.; Boatner, Lynn A.; Gillies, George T.

    1999-03-23

    A high temperature phosphor consists essentially of a material having the general formula LuPO.sub.4 :Dy.sub.(x),Eu.sub.y) wherein: 0.1 wt %.ltoreq.x.ltoreq.20 wt % and 0.1 wt %.ltoreq.y.ltoreq.20 wt %. The high temperature phosphor is in contact with an article whose temperature is to be determined. The article having the phosphor in contact with it is placed in the environment for which the temperature of the article is to be determined. The phosphor is excited by a laser causing the phosphor to fluoresce. The emission from the phosphor is optically focused into a beam-splitting mirror which separates the emission into two separate emissions, the emission caused by the dysprosium dopant and the emission caused by the europium dopent. The separated emissions are optically filtered and the intensities of the emission are detected and measured. The ratio of the intensity of each emission is determined and the temperature of the article is calculated from the ratio of the intensities of the separate emissions.

  1. High throughput optical scanner

    DOE Patents [OSTI]

    Basiji, David A. (Seattle, WA); van den Engh, Gerrit J. (Seattle, WA)

    2001-01-01

    A scanning apparatus is provided to obtain automated, rapid and sensitive scanning of substrate fluorescence, optical density or phosphorescence. The scanner uses a constant path length optical train, which enables the combination of a moving beam for high speed scanning with phase-sensitive detection for noise reduction, comprising a light source, a scanning mirror to receive light from the light source and sweep it across a steering mirror, a steering mirror to receive light from the scanning mirror and reflect it to the substrate, whereby it is swept across the substrate along a scan arc, and a photodetector to receive emitted or scattered light from the substrate, wherein the optical path length from the light source to the photodetector is substantially constant throughout the sweep across the substrate. The optical train can further include a waveguide or mirror to collect emitted or scattered light from the substrate and direct it to the photodetector. For phase-sensitive detection the light source is intensity modulated and the detector is connected to phase-sensitive detection electronics. A scanner using a substrate translator is also provided. For two dimensional imaging the substrate is translated in one dimension while the scanning mirror scans the beam in a second dimension. For a high throughput scanner, stacks of substrates are loaded onto a conveyor belt from a tray feeder.

  2. High Performance Buildings Database

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    The High Performance Buildings Database is a shared resource for the building industry, a unique central repository of in-depth information and data on high-performance, green building projects across the United States and abroad. The database includes information on the energy use, environmental performance, design process, finances, and other aspects of each project. Members of the design and construction teams are listed, as are sources for additional information. In total, up to twelve screens of detailed information are provided for each project profile. Projects range in size from small single-family homes or tenant fit-outs within buildings to large commercial and institutional buildings and even entire campuses. The database is a data repository as well. A series of Web-based data-entry templates allows anyone to enter information about a building project into the database. Once a project has been submitted, each of the partner organizations can review the entry and choose whether or not to publish that particular project on its own Web site.

  3. Improving in vitro Sertoli cell/gonocyte co-culture model for assessing male reproductive toxicity: Lessons learned from comparisons of cytotoxicity versus genomic responses to phthalates

    SciTech Connect (OSTI)

    Yu Xiaozhong; Hong, Sung Woo; Moreira, Estefania G.; Faustman, Elaine M.

    2009-09-15

    Gonocytes exist in the neonatal testis and represent a transient population of male germ-line stem cells. It has been shown that stem cell self-renewal and progeny production is probably controlled by the neighboring differentiated cells and extracellular matrix (ECM) in vivo known as niches. Recently, we developed an in vitro three-dimensional (3D) Sertoli cell/gonocyte co-culture (SGC) model with ECM overlay, which creates an in vivo-like niche and supports germ-line stem cell functioning within a 3D environment. In this study, we applied morphological and cytotoxicity evaluations, as well as microarray-based gene expression to examine the effects of different phthalate esters (PE) on this model. Known in vivo male developmentally toxic PEs (DTPE) and developmentally non-toxic PEs (DNTPE) were evaluated. We observed that DTPE induced significantly greater dose-dependent morphological changes, a decrease in cell viability and an increase in cytotoxicity compared to those treated with DNTPE. Moreover, the gene expression was more greatly altered by DTPE than by DNTPE and non-supervised cluster analysis allowed the discrimination of DTPE from the DNTPE. Our systems-based GO-Quant analysis showed significant alterations in the gene pathways involved in cell cycle, phosphate transport and apoptosis regulation with DTPE but not with DNTPE treatment. Disruptions of steroidogenesis related-gene expression such as Star, Cyp19a1, Hsd17b8, and Nr4a3 were observed in the DTPE group, but not in the DNTPE group. In summary, our observation on cell viability, cytotoxicity, and microarray-based gene expression analysis induced by PEs demonstrate that our in vitro 3D-SGC system mimicked in vivo responses for PEs and suggests that the 3D-SGC system might be useful in identifying developmental reproductive toxicants.

  4. Local Control, Toxicity, and Cosmesis in Women >70 Years Enrolled in the American Society of Breast Surgeons Accelerated Partial Breast Irradiation Registry Trial

    SciTech Connect (OSTI)

    Khan, Atif J.; Vicini, Frank A.; Beitsch, Peter; Goyal, Sharad; Kuerer, Henry M.; Keisch, Martin; Quiet, Coral; Zannis, Victor; Keleher, Angela; Snyder, Howard; Gittleman, Mark; Whitworth, Pat; Fine, Richard; Lyden, Maureen; Haffty, Bruce G.; American Society of Breast Surgeons, Columbia, MD

    2012-10-01

    Purpose: The American Society of Breast Surgeons enrolled women in a registry trial to prospectively study patients treated with the MammoSite Radiation Therapy System breast brachytherapy device. The present report examined the outcomes in women aged >70 years enrolled in the trial. Methods and Materials: A total of 1,449 primary early stage breast cancers were treated in 1,440 women. Of these, 537 occurred in women >70 years old. Fisher's exact test was performed to correlate age ({<=}70 vs. >70 years) with toxicity and with cosmesis. The association of age with local recurrence (LR) failure times was investigated by fitting a parametric model. Results: Older women were less likely to develop telangiectasias than younger women (7.9% vs. 12.4%, p = 0.0083). The incidence of other toxicities was similar. Cosmesis was good or excellent in 92% of the women >70 years old. No significant difference was found in LR as a function of age. The 5-year actuarial LR rate with invasive disease for the older vs. younger population was 2.79% and 2.92%, respectively (p = 0.5780). In women >70 years with hormone-sensitive tumors {<=}2 cm who received hormonal therapy (n = 195), the 5-year actuarial rate of LR, overall survival, disease-free survival, and cause-specific survival was 2.06%, 89.3%, 87%, and 97.5%, respectively. These outcomes were similar in women who did not receive hormonal therapy. Women with small, estrogen receptor-negative disease had worse LR, overall survival, and disease-free survival compared with receptor-positive patients. Conclusions: Accelerated partial breast irradiation with the MammoSite radiation therapy system resulted in low toxicity and produced similar cosmesis and local control at 5 years in women >70 years compared with younger women. This treatment should be considered as an alternative to omitting adjuvant radiotherapy for older women with small-volume, early-stage breast cancer.

  5. High Temperature Membrane Working Group

    Broader source: Energy.gov [DOE]

    The High Temperature Membrane Working Group consists of government, industry, and university researchers interested in developing high temperature membranes for fuel cells.

  6. Environmental acceptability of high-performance alternatives for depleted uranium penetrators

    SciTech Connect (OSTI)

    Kerley, C.R.; Easterly, C.E.; Eckerman, K.F.

    1996-08-01

    The Army`s environmental strategy for investigating material substitution and management is to measure system environmental gains/losses in all phases of the material management life cycle from cradle to grave. This study is the first in a series of new investigations, applying material life cycle concepts, to evaluate whether there are environmental benefits from increasing the use of tungsten as an alternative to depleted uranium (DU) in Kinetic Energy Penetrators (KEPs). Current military armor penetrators use DU and tungsten as base materials. Although DU alloys have provided the highest performance of any high-density alloy deployed against enemy heavy armor, its low-level radioactivity poses a number of environmental risks. These risks include exposures to the military and civilian population from inhalation, ingestion, and injection of particles. Depleted uranium is well known to be chemically toxic (kidney toxicity), and workplace exposure levels are based on its renal toxicity. Waste materials containing DU fragments are classified as low-level radioactive waste and are regulated by the Nuclear Regulatory Commission. These characteristics of DU do not preclude its use in KEPs. However, long-term management challenges associated with KEP deployment and improved public perceptions about environmental risks from military activities might be well served by a serious effort to identify, develop, and substitute alternative materials that meet performance objectives and involve fewer environmental risks. Tungsten, a leading candidate base material for KEPS, is potentially such a material because it is not radioactive. Tungsten is less well studied, however, with respect to health impacts and other environmental risks. The present study is designed to contribute to the understanding of the environmental behavior of tungsten by synthesizing available information that is relevant to its potential use as a penetrator.

  7. High-␤,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ␤, improved confinement reversed-field pinch plasmas at high density M. D. Wyman, 1,a͒ B. E. Chapman, 1 J. W. Ahn, 1 A. F. Almagri, 1 J. K. Anderson, 1 F. Bonomo, 2 D. L. Brower, 3 S. K. Combs, 4 D. Craig, 1,5 D. J. Den Hartog, 1 B. H. Deng, 3 W. X. Ding, 3 F. Ebrahimi, 1 D. A. Ennis, 1 G. Fiksel, 1 C. R. Foust, 4 P. Franz, 2 S. Gangadhara, 1 J. A. Goetz, 1 R. O'Connell, 1 S. P. Oliva, 1 S. C. Prager, 1 J. A. Reusch, 1 J. S. Sarff, 1 H. D. Stephens, 1 and T. Yates 3 1 Department of Physics,

  8. High voltage feedthrough bushing

    DOE Patents [OSTI]

    Brucker, John P. (Espanola, NM)

    1993-01-01

    A feedthrough bushing for a high voltage diode provides for using compression sealing for all sealing surfaces. A diode assembly includes a central conductor extending through the bushing and a grading ring assembly circumferentially surrounding and coaxial with the central conductor. A flexible conductive plate extends between and compressively seals against the central conductor and the grading ring assembly, wherein the flexibility of the plate allows inner and outer portions of the plate to axially translate for compression sealing against the central conductor and the grading ring assembly, respectively. The inner portion of the plate is bolted to the central conductor for affecting sealing. A compression beam is also bolted to the central conductor and engages the outer portion of the plate to urge the outer portion toward the grading ring assembly to obtain compression sealing therebetween.

  9. High Efficiency, Clean Combustion

    SciTech Connect (OSTI)

    Donald Stanton

    2010-03-31

    Energy use in trucks has been increasing at a faster rate than that of automobiles within the U.S. transportation sector. According to the Energy Information Administration (EIA) Annual Energy Outlook (AEO), a 23% increase in fuel consumption for the U.S. heavy duty truck segment is expected between 2009 to 2020. The heavy duty vehicle oil consumption is projected to grow between 2009 and 2050 while light duty vehicle (LDV) fuel consumption will eventually experience a decrease. By 2050, the oil consumption rate by LDVs is anticipated to decrease below 2009 levels due to CAFE standards and biofuel use. In contrast, the heavy duty oil consumption rate is anticipated to double. The increasing trend in oil consumption for heavy trucks is linked to the vitality, security, and growth of the U.S. economy. An essential part of a stable and vibrant U.S. economy is a productive U.S. trucking industry. Studies have shown that the U.S. gross domestic product (GDP) is strongly correlated to freight transport. Over 90% of all U.S. freight tonnage is transported by diesel power and over 75% is transported by trucks. Given the vital role that the trucking industry plays in the economy, improving the efficiency of the transportation of goods was a central focus of the Cummins High Efficient Clean Combustion (HECC) program. In a commercial vehicle, the diesel engine remains the largest source of fuel efficiency loss, but remains the greatest opportunity for fuel efficiency improvements. In addition to reducing oil consumption and the dependency on foreign oil, this project will mitigate the impact on the environment by meeting US EPA 2010 emissions regulations. Innovation is a key element in sustaining a U.S. trucking industry that is competitive in global markets. Unlike passenger vehicles, the trucking industry cannot simply downsize the vehicle and still transport the freight with improved efficiency. The truck manufacturing and supporting industries are faced with numerous challenges to reduce oil consumption and greenhouse gases, meet stringent emissions regulations, provide customer value, and improve safety. The HECC program successfully reduced engine fuel consumption and greenhouse gases while providing greater customer valve. The US EPA 2010 emissions standard poses a significant challenge for developing clean diesel powertrains that meet the DoE Vehicle Technologies Multi-Year Program Plan (MYPP) for fuel efficiency improvement while remaining affordable. Along with exhaust emissions, an emphasis on heavy duty vehicle fuel efficiency is being driven by increased energy costs as well as the potential regulation of greenhouse gases. An important element of the success of meeting emissions while significantly improving efficiency is leveraging Cummins component technologies such as fuel injection equipment, aftertreatment, turbomahcinery, electronic controls, and combustion systems. Innovation in component technology coupled with system integration is enabling Cummins to move forward with the development of high efficiency clean diesel products with a long term goal of reaching a 55% peak brake thermal efficiency for the engine plus aftertreatment system. The first step in developing high efficiency clean products has been supported by the DoE co-sponsored HECC program. The objectives of the HECC program are: (1) To design and develop advanced diesel engine architectures capable of achieving US EPA 2010 emission regulations while improving the brake thermal efficiency by 10% compared to the baseline (a state of the art 2007 production diesel engine). (2) To design and develop components and subsystems (fuel systems, air handling, controls, etc) to enable construction and development of multi-cylinder engines. (3) To perform an assessment of the commercial viability of the newly developed engine technology. (4) To specify fuel properties conducive to improvements in emissions, reliability, and fuel efficiency for engines using high-efficiency clean combustion (HECC) technologies. To demonstrate the technology is compatible with B2

  10. Hypoxia inducible factor-1 (HIF-1)flavin containing monooxygenase-2 (FMO-2) signaling acts in silver nanoparticles and silver ion toxicity in the nematode, Caenorhabditis elegans

    SciTech Connect (OSTI)

    Eom, Hyun-Jeong; Ahn, Jeong-Min; Kim, Younghun; Choi, Jinhee

    2013-07-15

    In the present study, nanotoxicity mechanism associated with silver nanoparticles (AgNPs) exposure was investigated on the nematode, Caenorhabditis elegans focusing on the hypoxia response pathway. In order to test whether AgNPs-induced hypoxia inducible factor-1 (HIF-1) activation was due to hypoxia or to oxidative stress, depletion of dissolved oxygen (DO) in the test media and a rescue effect using an antioxidant were investigated, respectively. The results suggested that oxidative stress was involved in activation of the HIF-1 pathway. We then investigated the toxicological implications of HIF-1 activation by examining the HIF-1 mediated transcriptional response. Of the genes tested, increased expression of the flavin containing monooxygenase-2 (FMO-2) gene was found to be the most significant as induced by AgNPs exposure. We found that AgNPs exposure induced FMO-2 activation in a HIF-1 and p38 MAPK PMK-1 dependent manner, and oxidative stress was involved in it. We conducted all experiments to include comparison of AgNPs and AgNO{sub 3} in order to evaluate whether any observed toxicity was due to dissolution or particle specific. The AgNPs and AgNO{sub 3} did not produce any qualitative differences in terms of exerting toxicity in the pathways observed in this study, however, considering equal amount of silver mass, in every endpoint tested the AgNPs were found to be more toxic than AgNO{sub 3}. These results suggest that Ag nanotoxicity is dependent not only on dissolution of Ag ion but also on particle specific effects and HIF-1FMO-2 pathway seems to be involved in it. - Highlights: HIF-1 signaling was investigated in C. elegans exposed to AgNPs and AgNO{sub 3}. HIF-1 and PMK-1 were needed for AgNPs- and AgNO{sub 3}-induced fmo-2 gene expression. PMK-1HIF-1FMO-2 pathway was dependent on oxidative stress. AgNPs and AgNO{sub 3} did not produce any qualitative differences in HIF-1 signaling. AgNPs were more toxic than an equal amount of silver mass contained in AgNO{sub 3}.

  11. Vehicle Technologies Office Merit Review 2015: High Energy High Power

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Battery Exceeding PHEV-40 Requirements | Department of Energy Energy High Power Battery Exceeding PHEV-40 Requirements Vehicle Technologies Office Merit Review 2015: High Energy High Power Battery Exceeding PHEV-40 Requirements Presentation given by TIAX LLC at 2015 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting about high energy high power battery exceeding PHEV-40 requirements. PDF icon es209_rempel_2015_p.pdf More

  12. Challenges to achievement of metal sustainability in our high-tech society

    SciTech Connect (OSTI)

    Izatt, Reed M.; Izatt, Steven R.; Bruening, Ronald L.; Izatt, Neil; Moyer, Bruce A

    2014-01-01

    Achievement of sustainability in metal life cycles from mining of virgin ore to consumer and industrial devices to end-of-life products requires greatly increased recycling and improved processing of metals. Electronic and other high-tech products containing precious, toxic, and specialty metals usually have short lifetimes and low recycling rates. Products containing these metals generally are incinerated, discarded as waste in landfills, or dismantled in informal recycling using crude and environmentally irresponsible procedures. Low metal recycling rates coupled with increasing demand for products containing them necessitate increased mining with attendant environmental, health, energy, water, and carbon-footprint consequences. In this tutorial review, challenges to achieving metal sustainability in present high-tech society are presented; health, environmental, and economic incentives for various stakeholders to improve metal sustainability are discussed; a case for technical improvements in separations technology, especially employing molecular recognition, is given; and global consequences of continuing on the present path are examined.

  13. FSU High Energy Physics

    SciTech Connect (OSTI)

    Prosper, Harrison B.; Adams, Todd; Askew, Andrew; Berg, Bernd; Blessing, Susan K.; Okui, Takemichi; Owens, Joseph F.; Reina, Laura; Wahl, Horst D.

    2014-12-01

    The High Energy Physics group at Florida State University (FSU), which was established in 1958, is engaged in the study of the fundamental constituents of matter and the laws by which they interact. The group comprises theoretical and experimental physicists, who sometimes collaborate on projects of mutual interest. The report highlights the main recent achievements of the group. Significant, recent, achievements of the group’s theoretical physicists include progress in making precise predictions in the theory of the Higgs boson and its associated processes, and in the theoretical understanding of mathematical quantities called parton distribution functions that are related to the structure of composite particles such as the proton. These functions are needed to compare data from particle collisions, such as the proton-proton collisions at the CERN Large Hadron Collider (LHC), with theoretical predictions. The report also describes the progress in providing analogous functions for heavy nuclei, which find application in neutrino physics. The report highlights progress in understanding quantum field theory on a lattice of points in space and time (an area of study called lattice field theory), the progress in constructing several theories of potential new physics that can be tested at the LHC, and interesting new ideas in the theory of the inflationary expansion of the very early universe. The focus of the experimental physicists is the Compact Muon Solenoid (CMS) experiment at CERN. The report, however, also includes results from the D0 experiment at Fermilab to which the group made numerous contributions over a period of many years. The experimental group is particularly interested in looking for new physics at the LHC that may provide the necessary insight to extend the standard model (SM) of particle physics. Indeed, the search for new physics is the primary task of contemporary particle physics, one motivated by the need to explain certain facts, such as the non-zero neutrino masses or the overwhelming astrophysical evidence for an invisible form of matter, called dark matter, that has had a marked effect on the evolution of structure in the universe. The report highlights the main, recent, experimental achievements of the experimental group, which include the investigation of properties of the W and Z bosons; the search for new heavy stable charged particles and the search for a proposed property of nature called supersymmetry in proton-proton collisions that yield high energy photons. In addition, we report a few results from a more general search for supersymmetry at the LHC, initiated by the group. The report also highlights the group's significant contributions, both theoretical and experimental, to the 2012 discovery of the Higgs boson and the measurement of its properties.

  14. High Temperature Membrane Working Group

    Broader source: Energy.gov [DOE]

    This presentation provides an overview of the High Temperature Membrane Working Group Meeting in May 2007.

  15. High Performance Network Monitoring

    SciTech Connect (OSTI)

    Martinez, Jesse E

    2012-08-10

    Network Monitoring requires a substantial use of data and error analysis to overcome issues with clusters. Zenoss and Splunk help to monitor system log messages that are reporting issues about the clusters to monitoring services. Infiniband infrastructure on a number of clusters upgraded to ibmon2. ibmon2 requires different filters to report errors to system administrators. Focus for this summer is to: (1) Implement ibmon2 filters on monitoring boxes to report system errors to system administrators using Zenoss and Splunk; (2) Modify and improve scripts for monitoring and administrative usage; (3) Learn more about networks including services and maintenance for high performance computing systems; and (4) Gain a life experience working with professionals under real world situations. Filters were created to account for clusters running ibmon2 v1.0.0-1 10 Filters currently implemented for ibmon2 using Python. Filters look for threshold of port counters. Over certain counts, filters report errors to on-call system administrators and modifies grid to show local host with issue.

  16. High pressure capillary connector

    SciTech Connect (OSTI)

    Renzi, Ronald F.

    2005-08-09

    A high pressure connector capable of operating at pressures of 40,000 psi or higher is provided. This connector can be employed to position a first fluid-bearing conduit that has a proximal end and a distal end to a second fluid-bearing conduit thereby providing fluid communication between the first and second fluid-bearing conduits. The connector includes (a) an internal fitting assembly having a body cavity with (i) a lower segment that defines a lower segment aperture and (ii) an interiorly threaded upper segment, (b) a first member having a first member aperture that traverses its length wherein the first member aperture is configured to accommodate the first fluid-bearing conduit and wherein the first member is positioned in the lower segment of the internal fitting assembly, and (c) a second member having a second member aperture that traverses its length wherein the second member is positioned in the upper segment of the fitting assembly and wherein a lower surface of the second member is in contact with an upper surface of the first member to assert a compressive force onto the first member and wherein the first member aperture and the second member aperture are coaxial.

  17. High power connection system

    DOE Patents [OSTI]

    Schaefer, Christopher E. (Warren, OH); Beer, Robert C. (Noblesville, IN); McCall, Mark D. (Youngstown, OH)

    2000-01-01

    A high power connection system adapted for automotive environments which provides environmental and EMI shielding includes a female connector, a male connector, and a panel mount. The female connector includes a female connector base and a snap fitted female connector cover. The male connector includes a male connector base and a snap fitted male connector cover. The female connector base has at least one female power terminal cavity for seatably receiving a respective female power terminal. The male connector base has at least one male power terminal cavity for seatably receiving a respective male power terminal. The female connector is covered by a cover seal and a conductive shroud. A pair of lock arms protrude outward from the front end of the male connector base, pass through the panel mount and interface with a lever of a lever rotatably connected to the shroud to thereby mechanically assist mating of the male and female connectors. Safety terminals in the male and female connectors provide a last-to-connect-first-to-break connection with an HVIL circuit.

  18. High capacity oil burner

    SciTech Connect (OSTI)

    Pedrosa, O.A. Jr.; Couto, N.C.; Fanqueiro, R.C.C.

    1983-11-01

    The present invention relates to a high capacity oil burner comprising a cylindrical atomizer completely surrounded by a protective cylindrical housing having a diameter from 2 to 3 times greater than the diameter of said atomizer; liquid fuels being injected under pressure into said atomizer and accumulating within said atomizer in a chamber for the accumulation of liquid fuels, and compressed air being injected into a chamber for the accumulation of air; cylindrical holes communicating said chamber for the accumulation of liquid fuels with the outside and cylindrical holes communicating said chamber for the accumulation of air with said cylindrical holes communicating the chamber for the accumulation of liquids with the outside so that the injection of compressed air into said liquid fuel discharge holes atomizes said fuel which is expelled to the outside through the end portions of said discharge holes which are circumferentially positioned to be burnt by a pilot flame; said protecting cylindrical housing having at its ends perforated circular rings into which water is injected under pressure to form a protecting fan-like water curtain at the rear end of the housing and a fan-like water curtain at the flame to reduce the formation of soot; the burning efficiency of said burner being superior to 30 barrels of liquid fuel per day/kg of the apparatus.

  19. A study of toxic emissions from a coal-fired power plant utilizing an ESP while demonstrating the ICCT CT-121 FGD Project. Final report

    SciTech Connect (OSTI)

    Not Available

    1994-06-16

    The US Department of Energy is performing comprehensive assessments of toxic emissions from eight selected coal-fired electric utility units. This program responds to the Clean Air Act Amendments of 1990, which require the US Environmental Protection Agency (EPA) to evaluate emissions of hazardous air pollutants (HAPs) from electric utility power plants for Potential health risks. The resulting data will be furnished to EPA utility power plants and health risk determinations. The assessment of emissions involves the collection and analysis of samples from the major input, process, and output streams of each of the eight power plants for selected hazardous Pollutants identified in Title III of the Clean Air Act. Additional goals are to determine the removal efficiencies of pollution control subsystems for these selected pollutants and the Concentrations associated with the particulate fraction of the flue gas stream as a function of particle size. Material balances are being performed for selected pollutants around the entire power plant and several subsystems to identify the fate of hazardous substances in each utility system. Radian Corporation was selected to perform a toxics assessment at a plant demonstrating an Innovative Clean Coal Technology (ICCT) Project. The site selected is Plant Yates Unit No. 1 of Georgia Power Company, which includes a Chiyoda Thoroughbred-121 demonstration project.

  20. A modified inflammatory bowel disease questionnaire and the Vaizey Incontinence questionnaire are more sensitive measures of acute gastrointestinal toxicity during pelvic radiotherapy than RTOG grading

    SciTech Connect (OSTI)

    Khalid, Usman; McGough, Camilla; Hackett, Claire; Blake, Peter; Harrington, Kevin J.; Khoo, Vincent S.; Tait, Diana; Norman, Andrew R.; Andreyev, H. Jervoise N. . E-mail: j@andreyev.demon.co.uk

    2006-04-01

    Purpose: Simple scales with greater sensitivity than Radiation Therapy Oncology Group (RTOG) grading to detect acute gastrointestinal toxicity during pelvic radiotherapy, could be clinically useful. Methods and Materials: Do questionnaires used in benign gastrointestinal diseases detect toxicity in patients undergoing radiotherapy? The patient-completed Inflammatory Bowel Disease (IBDQ) and Vaizey Incontinence questionnaires were compared prospectively at baseline and at Week 5 to physician-completed RTOG grading. Results: A total of 107 patients, median age 63 years, were recruited. After 5 weeks of treatment, patients with gynecologic and gastrointestinal cancer were more symptomatic than urologic patients (p 0.012; p = 0.014). Overall, 94% had altered bowel habits, 80% loose stool, 74% frequency, 65% difficult gas, 60% pain, >48% distress, 44% tenesmus, >40% restrictions in daily activity, 39% urgency, 37% fecal incontinence, and 40% required antidiarrheal medication. The median RTOG score was 1 (range, 0-2), median IBDQ score 204.5 (range, 74-224), and median Vaizey score 5 (range, 0-20). Chemotherapy preceding radiotherapy increased fecal incontinence (p 0.002). RTOG scores stabilized after 3 weeks, IBDQ scores peaked at Week 4, and Vaizey scores worsened throughout treatment. IBDQ and Vaizey scores distinguished between groups with different RTOG scores. Conclusion: The IBDQ and Vaizey questionnaires are reliable and sensitive, offering greater insight into the severity and range of symptoms compared with RTOG grading.

  1. High-Rate, High-Capacity Binder-Free Electrode

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Office of Energy Efficiency and Renewable Energy operated by the Alliance for Sustainable Energy, LLC High-Rate, High-Capacity Binder-Free Electrode Patent: PCT-09-41 Chunmei Ban ...

  2. High density, high-aspect-ratio precision polyimide nanofilters | Argonne

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    National Laboratory High density, high-aspect-ratio precision polyimide nanofilters December 1, 2009 Tweet EmailPrint Collaborative users from Creatv MicroTech, Inc. and Los Alamos National Laboratory, working with CNM's Nanofabrication & Devices Group, have demonstrated a novel fabrication process that produces high-porosity polymer nanofilters with smooth, uniform. and straight pores and high aspect ratios. Nanofilters have a wide range of applications for various size-exclusion-based

  3. Toward comprehensive studies of liquids at high pressures and high

    Office of Scientific and Technical Information (OSTI)

    temperatures: Combined structure, elastic wave velocity, and viscosity measurements in the Paris–Edinburgh cell (Journal Article) | SciTech Connect SciTech Connect Search Results Journal Article: Toward comprehensive studies of liquids at high pressures and high temperatures: Combined structure, elastic wave velocity, and viscosity measurements in the Paris–Edinburgh cell Citation Details In-Document Search Title: Toward comprehensive studies of liquids at high pressures and high

  4. High dose rate intraluminal irradiation in recurrent endobronchial carcinoma

    SciTech Connect (OSTI)

    Seagren, S.L.; Harrell, J.H.; Horn, R.A.

    1985-12-01

    Palliative therapy for previously irradiated patients with symptomatic recurrent endobronchial malignancy is a difficult problem. We have had the opportunity to treat 20 such patients with high dose rate (50-100 rad/min) endobronchial brachytherapy. Eligible patients had received previous high dose thoracic irradiation (TDF greater than or equal to 90), a performance status of greater than or equal to 50, and symptoms caused by a bronchoscopically defined and implantable lesion. The radiation is produced by a small cobalt-60 source (0.7 Ci) remotely afterloaded by cable control. The source is fed into a 4 mm diameter catheter which is placed with bronchoscopic guidance; it may oscillate if necessary to cover the lesion. A dose of 1,000 rad at 1 cm from the source is delivered. We have performed 22 procedures in 20 patients, four following YAG laser debulking. Most had cough, some with hemoptysis. Eight had dyspnea secondary to obstruction and three had obstructive pneumonitis. In 12, symptoms recurred with a mean time to recurrence of 4.3 months (range 1-9 months). Eighteen patients were followed-up and reexamined via bronchoscope 1-2.5 months following the procedure; two were lost to follow-up. All had at least 50 percent clearance of tumor, and six had complete clearance; most regressions were documented on film or videotape. In six, the palliation was durable. The procedure has been well tolerated with no toxicity. We conclude that palliative endobronchial high dose rate brachytherapy is a useful palliative modality in patients with recurrent endobronchial symptomatic carcinoma.

  5. High efficiency proportional neutron detector with solid liner internal structures

    DOE Patents [OSTI]

    Kisner, Roger Allen; Holcomb, David Eugene; Brown, Gilbert M.

    2014-08-05

    A tube-style neutron detector, a panel-style neutron detector incorporating a plurality of tube-style neutron detectors, and a panel-style neutron detector including a plurality of anode wires are provided. A plurality of channels is provided in a neutron detector such that each channel has an inner surface of a coating layer including a neutron-absorbing material. A wire anode is provided at end of each channel so that electrons generated by a charged daughter particle generated by a neutron are collected to detect a neutron-matter interaction. Moderator units can be incorporated into a neutron detector to provide improved detection efficiencies and/or to determine neutron energy spectrum. Gas-based proportional response from the neutron detectors can be employed for special nuclear material (SNM) detection. This neutron detector can provide similar performance to .sup.3He-based detectors without requiring .sup.3He and without containing toxic, flammable, or high-pressure materials.

  6. Ultra high vacuum broad band high power microwave window

    DOE Patents [OSTI]

    Nguyen-Tuong, Viet (Seaford, VA); Dylla, III, Henry Frederick (Yorktown, VA)

    1997-01-01

    An improved high vacuum microwave window has been developed that utilizes high density polyethylene coated on two sides with SiOx, SiNx, or a combination of the two. The resultant low dielectric and low loss tangent window creates a low outgassing, low permeation seal through which broad band, high power microwave energy may be passed. No matching device is necessary and the sealing technique is simple. The features of the window are broad band transmission, ultra-high vacuum compatibility with a simple sealing technique, low voltage standing wave ratio, high power transmission and low cost.

  7. Ultra high vacuum broad band high power microwave window

    DOE Patents [OSTI]

    Nguyen-Tuong, V.; Dylla, H.F. III

    1997-11-04

    An improved high vacuum microwave window has been developed that utilizes high density polyethylene coated on two sides with SiOx, SiNx, or a combination of the two. The resultant low dielectric and low loss tangent window creates a low outgassing, low permeation seal through which broad band, high power microwave energy may be passed. No matching device is necessary and the sealing technique is simple. The features of the window are broad band transmission, ultra-high vacuum compatibility with a simple sealing technique, low voltage standing wave ratio, high power transmission and low cost. 5 figs.

  8. APPARATUS FOR REGULATING HIGH VOLTAGE

    DOE Patents [OSTI]

    Morrison, K.G.

    1951-03-20

    This patent describes a high-voltage regulator of the r-f type wherein the modulation of the r-f voltage is accomplished at a high level, resulting in good stabilization over a large range of load conditions.

  9. Introduction to High Performance Computing

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Introduction to High Performance Computing Introduction to High Performance Computing June 10, 2013 Photo on 7 30 12 at 7.10 AM Downloads Download File Gerber-HPC-2.pdf...

  10. High-Pressure Hydrogen Tanks

    Broader source: Energy.gov [DOE]

    Presentation on High-Pressure Hydrogen Tanks for the DOE Hydrogen Delivery High-Pressure Tanks and Analysis Project Review Meeting held February 8-9, 2005 at Argonne National Laboratory

  11. High voltage variable diameter insulator

    DOE Patents [OSTI]

    Vanacek, D.L.; Pike, C.D.

    1982-07-13

    A high voltage feedthrough assembly having a tubular insulator extending between the ground plane ring and the high voltage ring. The insulator is made of Pyrex and decreases in diameter from the ground plane ring to the high voltage ring, producing equipotential lines almost perpendicular to the wall of the insulator to optimize the voltage-holding capability of the feedthrough assembly.

  12. Sensitivity to methylmercury toxicity is enhanced in oxoguanine glycosylase 1 knockout murine embryonic fibroblasts and is dependent on cellular proliferation capacity

    SciTech Connect (OSTI)

    Ondovcik, Stephanie L.; Tamblyn, Laura; McPherson, John Peter; Wells, Peter G.

    2013-07-01

    Methylmercury (MeHg) is a persistent environmental contaminant with potent neurotoxic action for which the underlying molecular mechanisms remain to be conclusively delineated. Our objectives herein were twofold: first, to corroborate our previous findings of an increased sensitivity of spontaneously-immortalized oxoguanine glycosylase 1-null (Ogg1{sup ?/?}) murine embryonic fibroblasts (MEFs) to MeHg through generation of Simian virus 40 (SV40) large T antigen-immortalized wild-type and Ogg1{sup ?/?} MEFs; and second, to determine whether MeHg toxicity is proliferation-dependent. As with the spontaneously-immortalized cells used previously, the SV40 large T antigen-immortalized cells exhibited similar tendencies to undergo MeHg-initiated cell cycle arrest, with increased sensitivity in the Ogg1{sup ?/?} MEFs as measured by clonogenic survival and DNA damage. Compared to exponentially growing cells, those seeded at a higher density exhibited compromised proliferation, which proved protective against MeHg-mediated cell cycle arrest and induction of DNA double strand breaks (DSBs), measured by phosphorylation of the core histone H2A variant (H2AX) on serine 139 (?H2AX), and by its functional confirmation by micronucleus assessment. This enhanced sensitivity of Ogg1{sup ?/?} MEFs to MeHg toxicity using discrete SV40 immortalization corroborates our previous studies, and suggests a novel role for OGG1 in minimizing MeHg-initiated DNA lesions that trigger replication-associated DSBs. Furthermore, proliferative capacity may determine MeHg toxicity in vivo and in utero. Accordingly, variations in cellular proliferative capacity and interindividual variability in repair activity may modulate the risk of toxicological consequences following MeHg exposure. - Highlights: SV40 large T antigen-immortalized Ogg1{sup ?/?} cells are more sensitive to MeHg. Sensitivity to MeHg is dependent on cellular proliferation capacity. OGG1 maintains genomic integrity following MeHg-initiated DNA damage. OGG1 may limit MeHg-initiated DNA lesions that trigger replication-associated DSBs. Variations in proliferation and repair activity may modulate toxicological risk.

  13. Update to agency for toxic substances and disease registry 2012 report on assessment of biota exposure to mercury originating from Savannah River Site.

    SciTech Connect (OSTI)

    Kuhne, W.

    2015-08-10

    The purpose of this report is to 1) update previous Savannah River National Laboratory (SRNL) assessment reports (Kvartek et al. 1994 and Halverson et al. 2008) on the fate of mercury in the Savannah River Site (SRS) environment and 2) address comments and recommendations from the review of SRS by the Agency for Toxic Substances and Disease Registry (ATSDR) concerning the evaluation of exposures to contaminants in biota originating from the SRS. The ATSDR reviewed and evaluated data from SRS, South Carolina Department of Health & Environmental Control (SCDHEC) and the Georgia Department of Natural Resources (GDNR) concerning the non-radioactive contaminant mercury. This report will provide a response and update to conclusions and recommendations made by the ATSDR.

  14. HIGH-INTENSITY, HIGH CHARGE-STATE HEAVY ION SOURCES

    SciTech Connect (OSTI)

    ALESSI,J.G.

    2004-08-16

    There are many accelerator applications for high intensity heavy ion sources, with recent needs including dc beams for RIA, and pulsed beams for injection into synchrotrons such as RHIC and LHC. The present status of sources producing high currents of high charge state heavy ions is reviewed. These sources include ECR, EBIS, and Laser ion sources. Benefits and limitations for these type sources are described. Possible future improvements in these sources are also mentioned.

  15. The role of intrahepatic CD3 +/CD4 −/CD8 − double negative T (DN T) cells in enhanced acetaminophen toxicity

    SciTech Connect (OSTI)

    Getachew, Yonas; Cusimano, Frank A.; James, Laura P.; Thiele, Dwain L.

    2014-10-15

    The role of the immune system, specifically NK, NKT and CD3 cells, in acetaminophen (APAP) induced liver injury remains inconsistently defined. In the present study, wild type (C57BL/6J) mice and granzyme B deficient (GrB −/−) mice were treated with acetaminophen to assess the role of the immune system in acute liver injury. Doses of acetaminophen that induced sub lethal liver injury in wild type mice unexpectedly produced fatal hepatotoxicity in granzyme B deficient (GrB −/−) mice. Analysis revealed that GrB −/− mice had an increased population of intrahepatic CD3 (+), CD4 (−), and CD8 (−) lymphocytes expressing the CD69 activation marker and Fas ligand. Depletion of these cells in the GrB −/− and wild type mice made them less susceptible to APAP injury, while depletion of NK1.1 (+) cells or both CD4 (+) and CD8 (+) T cells failed to provide the same hepatoprotection. Transfer of the GrB −/− IHLs further exacerbated liver injury and increased mortality in wild type mice but not in LRP/LPR mice, lacking fas expression. Conclusions: Acetaminophen toxicity is enhanced by the presence of activated, FasL expressing intrahepatic CD3 (+), CD4 (−), CD8 (−), NK1.1 (−) T cells. Depletion of these cells from GrB −/− mice and wild type mice greatly reduces mortality and improves the course of liver injury recovery. - Highlights: • Intrahepatic lymphocytes (IHLs) from GrB −/− mice harbor activated DNT cells. • IHLs from GrB −/− mice exhibit enhanced Fas ligand expression. • Acetaminophen toxicity is enhanced by activated, FasL expressing DNT cells.

  16. Late Patient-Reported Toxicity After Preoperative Radiotherapy or Chemoradiotherapy in Nonresectable Rectal Cancer: Results From a Randomized Phase III Study

    SciTech Connect (OSTI)

    Braendengen, Morten, E-mail: mortbrae@medisin.uio.no [Oslo University Hospital, Ulleval, Cancer Centre, Oslo (Norway); Department of Oncology and Pathology, Karolinska Institutet, Stockholm (Sweden); Tveit, Kjell Magne [Oslo University Hospital, Ulleval, Cancer Centre, Oslo (Norway); Faculty of Medicine, University of Oslo, Oslo (Norway); Bruheim, Kjersti [Oslo University Hospital, Ulleval, Cancer Centre, Oslo (Norway); Cvancarova, Milada [Department of Clinical Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo (Norway); Berglund, Ake [Department of Oncology, Radiology and Clinical Immunology, University of Uppsala, Uppsala (Sweden); Glimelius, Bengt [Department of Oncology and Pathology, Karolinska Institutet, Stockholm (Sweden); Department of Oncology, Radiology and Clinical Immunology, University of Uppsala, Uppsala (Sweden)

    2011-11-15

    Purpose: Preoperative chemoradiotherapy (CRT) is superior to radiotherapy (RT) in locally advanced rectal cancer, but the survival gain is limited. Late toxicity is, therefore, important. The aim was to compare late bowel, urinary, and sexual functions after CRT or RT. Methods and Materials: Patients (N = 207) with nonresectable rectal cancer were randomized to preoperative CRT or RT (2 Gy Multiplication-Sign 25 {+-} 5-fluorouracil/leucovorin). Extended surgery was often required. Self-reported late toxicity was scored according to the LENT SOMA criteria in a structured telephone interview and with questionnaires European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30), International Index of Erectile Function (IIEF), and sexual function -vaginal changes questionnaire (SVQ). Results: Of the 105 patients alive in Norway and Sweden after 4 to 12 years of follow-up, 78 (74%) responded. More patients in the CRT group had received a stoma (73% vs. 52%, p = 0.09). Most patients without a stoma (7 of 12 in CRT group and 9 of 16 in RT group) had incontinence for liquid stools or gas. No stoma and good anal function were seen in 5 patients (11%) in the CRT group and in 11 (30%) in the RT group (p = 0.046). Of 44 patients in the CRT group, 12 (28%) had had bowel obstruction compared with 5 of 33 (15%) in the RT group (p = 0.27). One-quarter of the patients reported urinary incontinence. The majority of men had severe erectile dysfunction. Few women reported sexual activity during the previous month. However, the majority did not have concerns about their sex life. Conclusions: Fecal incontinence and erectile dysfunction are frequent after combined treatment for locally advanced rectal cancer. There was a clear tendency for the problems to be more common after CRT than after RT.

  17. Androgenic endocrine disruptors in wastewater treatment plant effluents in India: Their influence on reproductive processes and systemic toxicity in male rats

    SciTech Connect (OSTI)

    Kumar, Vikas; Chakraborty, Ajanta; Viswanath, Gunda; Roy, Partha

    2008-01-01

    Endocrine-disrupting chemicals (EDC) are linked to human health and diseases as they mimic or block the normal functioning of endogenous hormones. The present work dealt with a comparative study of the androgenic potential of wastewater treatment plant (WWTP) influents and effluents in Northern region of India, well known for its polluted water. Water samples were screened for their androgenic potential using the Hershberger assay and when they were found positive for androgenicity, we studied their mode of action in intact rats. The data showed a significant change in the weight and structure of sex accessory tissues (SATs) of castrated and intact rats. Reverse transcriptase polymerase chain reaction (RT-PCR) analysis demonstrated a significant change in the expression patterns of the major steroidogenic enzymes in adrenal and testis: cytochrome P450{sub SCC}, cytochrome P450{sub C17}, 3{beta}-hydroxysteroid dehydrogenase, 17{beta}-hydroxysteroid dehydrogenase. This was further supported by increased enzymatic activities measured in vitro spectrophotometrically. Serum hormone profile showed a decreased level of gonadotrophic hormones and increased testosterone level. Further, increase in the serum level of alkaline phosphatase, SGPT and SGOT and histopathological changes in kidney and liver of treated animals, confirmed the toxic effects of contaminating chemicals. Analysis of water samples using HPLC and GC-MS showed the presence of various compounds and from them, four prominent aromatic compounds viz. nonylphenol, hexachlorobenzene and two testosterone equivalents, were identified. Our data suggest that despite rigorous treatment, the final treated effluent from WWTP still has enough androgenic and toxic compounds to affect general health.

  18. High-Temperature-High-Volume Lifting For Enhanced Geothermal...

    Open Energy Info (EERE)

    include high-temperature drive system materials, journal and thrust bearings, and corrosion and erosion-resistant lifting pump components. Finally, in Phase 3, the overall...

  19. High-Throughput, High-Precision Hot Testing Tool for High-Brightness

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Light-Emitting Diode Testing | Department of Energy Throughput, High-Precision Hot Testing Tool for High-Brightness Light-Emitting Diode Testing High-Throughput, High-Precision Hot Testing Tool for High-Brightness Light-Emitting Diode Testing Lead Performer: KLA-Tencor Corporation - Milpitas, CA Partners: Ocean Optics - Dunedin, FL DOE Total Funding: $3,994,729 Cost Share: $4,626,422 Project Term: 8/15/2012 - 9/30/2015 Funding Opportunity: SSL Manufacturing R&D Funding Opportunity

  20. Irradiation and Bevacizumab in High-Grade Glioma Retreatment Settings

    SciTech Connect (OSTI)

    Niyazi, Maximilian; Ganswindt, Ute; Schwarz, Silke Birgit [Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich (Germany); Kreth, Friedrich-Wilhelm; Tonn, Joerg-Christian [Department of Neurosurgery, Ludwig-Maximilians-University Munich, Munich (Germany); Geisler, Julia; Fougere, Christian la [Department of Nuclear Medicine, Ludwig-Maximilians-University Munich, Munich (Germany); Ertl, Lorenz; Linn, Jennifer [Department of Neuroradiology, Ludwig-Maximilians-University Munich, Munich (Germany); Siefert, Axel [Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich (Germany); Belka, Claus, E-mail: claus.belka@med.uni-muenchen.de [Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Munich (Germany)

    2012-01-01

    Purpose: Reirradiation is a treatment option for recurrent high-grade glioma with proven but limited effectiveness. Therapies directed against vascular endothelial growth factor have been shown to exert certain efficacy in combination with chemotherapy and have been safely tested in combination with radiotherapy in a small cohort of patients. To study the feasibility of reirradiation combined with bevacizumab treatment, the toxicity and treatment outcomes of this approach were analyzed retrospectively. Patients and Methods: After previous treatment with standard radiotherapy (with or without temozolomide) patients with recurrent malignant glioma received bevacizumab (10 mg/kg intravenous) on Day 1 and Day 15 during radiotherapy. Maintenance therapy was selected based on individual considerations, and mainly bevacizumab-containing regimens were chosen. Patients received 36 Gy in 18 fractions. Results: The data of the medical charts of the 30 patients were analyzed retrospectively. All were irradiated in a single institution and received either bevacizumab (n = 20), no additional substance (n = 7), or temozolomide (n = 3). Reirradiation was tolerated well, regardless of the added drug. In 1 patient treated with bevacizumab, a wound dehiscence occurred. Overall survival was significantly better in patients receiving bevacizumab (p = 0.03, log-rank test). In a multivariate proportional hazards Cox model, bevacizumab, Karnovsky performance status, and World Health Organization grade at relapse turned out to be the most important predictors for overall survival. Conclusion: Reirradiation with bevacizumab is a feasible and effective treatment for patients with recurrent high-grade gliomas. A randomized trial is warranted to finally answer the question whether bevacizumab adds substantial benefit to a radiotherapeutic retreatment setting.

  1. High resolution time interval meter

    DOE Patents [OSTI]

    Martin, A.D.

    1986-05-09

    Method and apparatus are provided for measuring the time interval between two events to a higher resolution than reliability available from conventional circuits and component. An internal clock pulse is provided at a frequency compatible with conventional component operating frequencies for reliable operation. Lumped constant delay circuits are provided for generating outputs at delay intervals corresponding to the desired high resolution. An initiation START pulse is input to generate first high resolution data. A termination STOP pulse is input to generate second high resolution data. Internal counters count at the low frequency internal clock pulse rate between the START and STOP pulses. The first and second high resolution data are logically combined to directly provide high resolution data to one counter and correct the count in the low resolution counter to obtain a high resolution time interval measurement.

  2. High Temperature, High Voltage Fully Integrated Gate Driver Circuit |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 10 DOE Vehicle Technologies and Hydrogen Programs Annual Merit Review and Peer Evaluation Meeting, June 7-11, 2010 -- Washington D.C. PDF icon ape003_tolbert_2010_p.pdf More Documents & Publications High Temperature, High Voltage Fully Integrated Gate Driver Circuit Wide Bandgap Materials Smart Integrated Power Module

  3. High Temperature, High Voltage Fully Integrated Gate Driver Circuit |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy 09 DOE Hydrogen Program and Vehicle Technologies Program Annual Merit Review and Peer Evaluation Meeting, May 18-22, 2009 -- Washington D.C. PDF icon ape_03_marlino.pdf More Documents & Publications High Temperature, High Voltage Fully Integrated Gate Driver Circuit Smart Integrated Power Module Wide Bandgap Materials

  4. High voltage variable diameter insulator

    DOE Patents [OSTI]

    Vanecek, David L. (Martinez, CA); Pike, Chester D. (Pinole, CA)

    1984-01-01

    A high voltage feedthrough assembly (10) having a tubular insulator (15) extending between the ground plane ring (16) and the high voltage ring (30). The insulator (15) is made of Pyrex and decreases in diameter from the ground plane ring (16) to the high voltage ring (30), producing equipotential lines almost perpendicular to the wall (27) of the insulator (15) to optimize the voltage-holding capability of the feedthrough assembly (10).

  5. Software and High Performance Computing

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Software and High Performance Computing Software and High Performance Computing Providing world-class high performance computing capability that enables unsurpassed solutions to complex problems of strategic national interest Contact thumbnail of Kathleen McDonald Head of Intellectual Property, Business Development Executive Kathleen McDonald Richard P. Feynman Center for Innovation (505) 667-5844 Email Software Computational physics, computer science, applied mathematics, statistics and the

  6. High Impact Technology Hub- Results

    Broader source: Energy.gov [DOE]

    Highlights, outcomes and activities to support the adoption of High Impact Technologies. Technology Highlights preview early results from current technology demonstrations. Case Studies overview...

  7. High Mesa | Open Energy Information

    Open Energy Info (EERE)

    High Mesa Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Exelon Wind Developer Exelon Wind Energy Purchaser Idaho Power Location...

  8. High Impact Technology HQ- Results

    Broader source: Energy.gov [DOE]

    Highlights, outcomes and activities to support the adoption of High Impact Technologies.  Technology Highlights preview early results from current technology demonstrations.  Case Studies overview...

  9. High field gradient particle accelerator

    DOE Patents [OSTI]

    Nation, John A.; Greenwald, Shlomo

    1989-01-01

    A high electric field gradient electron accelerator utilizing short duration, microwave radiation, and capable of operating at high field gradients for high energy physics applications or at reduced electric field gradients for high average current intermediate energy accelerator applications. Particles are accelerated in a smooth bore, periodic undulating waveguide, wherein the period is so selected that the particles slip an integral number of cycles of the r.f. wave every period of the structure. This phase step of the particles produces substantially continuous acceleration in a traveling wave without transverse magnetic or other guide means for the particle.

  10. High field gradient particle accelerator

    DOE Patents [OSTI]

    Nation, J.A.; Greenwald, S.

    1989-05-30

    A high electric field gradient electron accelerator utilizing short duration, microwave radiation, and capable of operating at high field gradients for high energy physics applications or at reduced electric field gradients for high average current intermediate energy accelerator applications is disclosed. Particles are accelerated in a smooth bore, periodic undulating waveguide, wherein the period is so selected that the particles slip an integral number of cycles of the r.f. wave every period of the structure. This phase step of the particles produces substantially continuous acceleration in a traveling wave without transverse magnetic or other guide means for the particle. 10 figs.

  11. Highly Enriched Uranium Materials Facility

    National Nuclear Security Administration (NNSA)

    Appropriations Subcommittee, is shown some of the technology in the Highly Enriched Uranium Materials Facility by Warehousing and Transportation Operations Manager Byron...

  12. Process for measuring degradation of sulfur hexafluoride in high voltage systems

    DOE Patents [OSTI]

    Sauers, I.

    1985-04-23

    This invention is a method of detecting the presence of toxic and corrosive by-products in high voltage systems produced by electrically induced degradation of SF/sub 6/ insulating gas in the presence of certain impurities. It is an improvement over previous methods because it is extremely sensitive, detecting by-products present in parts per billion concentrations, and because the device employed is of a simple design and takes advantage of the by-products natural affinity for fluoride ions. The method employs an ion-molecule reaction cell in which negative ions of the by-products are produced by fluorine attachment. These ions are admitted to a negative ion mass spectrometer and identified by their spectra. This spectrometry technique is an improvement over conventional techniques because the negative ion peaks are strong and not obscured by a major ion spectra of the SF/sub 6/ component as is the case in positive ion mass spectrometry.

  13. Process for measuring degradation of sulfur hexafluoride in high voltage systems

    DOE Patents [OSTI]

    Sauers, Isidor (Knoxville, TN)

    1986-01-01

    This invention is a method of detecting the presence of toxic and corrosive by-products in high voltage systems produced by electrically induced degradation of SF.sub.6 insulating gas in the presence of certain impurities. It is an improvement over previous methods because it is extremely sensitive, detecting by-products present in parts per billion concentrations, and because the device employed is of a simple design and takes advantage of the by-products natural affinity for fluoride ions. The method employs an ion-molecule reaction cell in which negative ions of the by-products are produced by fluorine attachment. These ions are admitted to a negative ion mass spectrometer and identified by their spectra. This spectrometry technique is an improvement over conventional techniques because the negative ion peaks are strong and not obscured by a major ion spectra of the SF.sub.6 component as is the case in positive ion mass spectrometry.

  14. HIGH

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Highlights International Oil Markets Prices. We have found little need to adjust our oil price forecast from last month's report, since no evidence of significantly more bullish (or bearish) sentiment on the world oil market has arisen since last month. Our estimate from the December Outlook for the November imported oil cost still looks good at $23.50 and our current estimate for December's price at $24.75 is only slightly above last month's expected December level ($24.50). Thus, annual

  15. High

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    confinement plasmas in the Madison Symmetric Torus reversed-field pinch a... B. E. Chapman, b) A. F. Almagri, J. K. Anderson, T. M. Biewer, P. K. Chattopadhyay, C.-S. Chiang, D. Craig, D. J. Den Hartog, G. Fiksel, C. B. Forest, A. K. Hansen, D. Holly, N. E. Lanier, R. O'Connell, S. C. Prager, J. C. Reardon, J. S. Sarff, and M. D. Wyman Department of Physics, University of Wisconsin-Madison, Madison, Wisconsin 53706 D. L. Brower, W. X. Ding, Y. Jiang, and S. D. Terry Department of Electrical

  16. High

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    throughput spectrometer for fast localized Doppler measurements D. Craig, a͒ D. J. Den Hartog, D. A. Ennis, S. Gangadhara, and D. Holly The Center for Magnetic Self-Organization in Laboratory and Astrophysical Plasmas, 1150 University Avenue, University of Wisconsin-Madison, Madison, Wisconsin 53706 ͑Received 26 June 2006; accepted 27 November 2006; published online 4 January 2007͒ A new custom-built duo spectrometer has been commissioned for fast localized Doppler measurements of plasma ions

  17. High

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    resolution soft x-ray tomography in the Madison Symmetric Torus P. Franz a) Consorzio RFX-Associazione EURATOM ENEA sulla fusione, Padova, Italy and Istituto Nazionale di Fisica della Materia, Unità di Ricerca di Padova, Italy F. Bonomo, G. Gadani, and L. Marrelli Consorzio RFX-Associazione EURATOM ENEA sulla fusione, Padova, Italy P. Martin and P. Piovesan Consorzio RFX-Associazione EURATOM ENEA sulla fusione, Padova, Italy and Istituto Nazionale di Fisica della Materia, Unità di Ricerca di

  18. high

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1999 Highlights International Oil Markets Prices. World oil prices for the remainder of 1999 and all of 2000 are expected to remain above $20 per barrel. EIA believes that prices will rise from average November levels (an estimated $23.50 per barrel for the price paid by U.S. refiners for imported crude) by about $1 per barrel by December, due to increased demand in the winter and Y2K precautionary building of end-user inventories (see a brief discussion on Y2K impacts below). The world oil

  19. high

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    0 Highlights International Oil Markets Prices. We have raised our world oil price projection by about $2 per barrel for this month because of assumed greater compliance by OPEC to targeted cuts, especially for the second quarter of 2000 (Figure 1). The expected decline in world petroleum inventories continues (Figure 2), and, given the generally stiff resolve of OPEC members to maintain production cuts, any sign of a turnaround in stocks may be postponed until later this year than previously

  20. high

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Summary Our short-term outlook for a wide array of energy prices has been adjusted upward as international and domestic energy supply conditions have tightened. We think that crude oil prices are as likely as not to end the year $2 to $3 per barrel higher than our previous projections. Thus, we think that the probability of West Texas Intermediate costing an average of $30 per barrel or more at midwinter is about 50 percent. On their current track, heating oil prices are likely to be about 30

  1. High temperature lightweight foamed cements

    DOE Patents [OSTI]

    Sugama, Toshifumi (Mastic Beach, NY)

    1989-01-01

    Cement slurries are disclosed which are suitable for use in geothermal wells since they can withstand high temperatures and high pressures. The formulation consists of cement, silica flour, water, a retarder, a foaming agent, a foam stabilizer, and a reinforcing agent. A process for producing these cements is also disclosed.

  2. High temperature lightweight foamed cements

    DOE Patents [OSTI]

    Sugama, Toshifumi.

    1989-10-03

    Cement slurries are disclosed which are suitable for use in geothermal wells since they can withstand high temperatures and high pressures. The formulation consists of cement, silica flour, water, a retarder, a foaming agent, a foam stabilizer, and a reinforcing agent. A process for producing these cements is also disclosed. 3 figs.

  3. Temperature controlled high voltage regulator

    DOE Patents [OSTI]

    Chiaro, Jr., Peter J. (Clinton, TN); Schulze, Gerald K. (Knoxville, TN)

    2004-04-20

    A temperature controlled high voltage regulator for automatically adjusting the high voltage applied to a radiation detector is described. The regulator is a solid state device that is independent of the attached radiation detector, enabling the regulator to be used by various models of radiation detectors, such as gas flow proportional radiation detectors.

  4. Electrokinetically pumped high pressure sprays

    DOE Patents [OSTI]

    Schoeniger, Joseph S. (Oakland, CA); Paul, Phillip H. (Livermore, CA); Schoeniger, Luke (Pittsford, NY)

    2005-11-01

    An electrokinetic pump capable of producing high pressure is combined with a nozzle having a submicron orifice to provide a high pressure spray device. Because of its small size, the device can be contained within medical devices such as an endoscope for delivering biological materials such as DNA, chemo therapeutic agents, or vaccines to tissues and cells.

  5. Electrokinetically pumped high pressure sprays

    DOE Patents [OSTI]

    Schoeniger, Joseph S. (Oakland, CA); Paul, Phillip H. (Livermore, CA); Schoeniger, Luke (Pittsford, NY)

    2002-01-01

    An electrokinetic pump capable of producing high pressure is combined with a nozzle having a submicron orifice to provide a high pressure spray device. Because of its small size, the device can be contained within medical devices such as an endoscope for delivering biological materials such as DNA, chemo therapeutic agents, or vaccines to tissues and cells.

  6. The use of field methods to evaluate the toxicity of lead to plants at a small arms firing range

    SciTech Connect (OSTI)

    DeShields, B.R.; Meredith, R.W.; Griffin, D.; Laughlin, T. [Harding Lawson Associates, Novato, CA (United States); Collins, W. [Army, Presidio of Monterey, CA (United States). Directorate of Environmental and Natural Resources Management

    1998-12-31

    The beach dunes at Fort Ord, California, were historically used as small arms firing ranges, resulting in the accumulation of spent bullets and varying concentrations of lead in soil. The form of the lead, and thus its bioavailability, is important in assessing associated ecological risks at firing ranges. Of particular interest at the beach firing ranges at Fort Ord are two species of buckwheat plants that provide habitat for an endangered butterfly. Initially, lead concentrations in soil and plant chaff were measured and root elongation bioassays were conducted. A linear correlation between lead in soil and lead in plant chaff was observed. However, the results of the bioassays were highly variable with no clear dose response pattern. Additional field studies were conducted to (1) further characterize lead concentrations in soil and plant tissue and (2) evaluate associations between soil lead concentrations and plant morphometric-variables. A relationship between soil and tissue lead concentrations was demonstrated. No significant associations between soil lead levels and plant health/condition were detected. Significant associations were observed between plant health/condition and factors other than lead.

  7. Multidisciplinary University Research Initiative: High Operating...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Research Initiative: High Operating Temperature Fluids Multidisciplinary University Research Initiative: High Operating Temperature Fluids Multidisciplinary University ...

  8. High-Performance Nanostructured Coating

    Broader source: Energy.gov [DOE]

    The High-Performance Nanostructured Coating fact sheet details a SunShot project led by a University of California, San Diego research team working to develop a new high-temperature spectrally selective coating for receiver surfaces. These receiver surfaces, used in concentrating solar power systems, rely on high-temperature SSCs to effectively absorb solar energy without emitting much blackbody radiation.The optical properties of the SSC directly determine the efficiency and maximum attainable temperature of solar receivers, which in turn influence the power-conversion efficiency and overall system cost.

  9. JC3 High Impact Assessment Bulletins | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Impact Assessment Bulletins JC3 High

  10. UESC and High Tech Facilities

    Broader source: Energy.gov [DOE]

    Presentation—given at the April 2012 Federal Utility Partnership Working Group (FUPWG) meeting—about the Federal Energy Management Program's (FEMP's) High-Tech Building Utility Energy Service Contract (UESC) Partnership led by the Lawrence Berkeley National Laboratory (LBNL).

  11. High temperature structural insulating material

    DOE Patents [OSTI]

    Chen, W.Y.

    1984-07-27

    A high temperature structural insulating material useful as a liner for cylinders of high temperature engines through the favorable combination of high service temperature (above about 800/sup 0/C), low thermal conductivity (below about 0.2 W/m/sup 0/C), and high compressive strength (above about 250 psi). The insulating material is produced by selecting hollow ceramic beads with a softening temperature above about 800/sup 0/C, a diameter within the range of 20-200 ..mu..m, and a wall thickness in the range of about 2 to 4 ..mu..m; compacting the beads and a compatible silicate binder composition under pressure and sintering conditions to provide the desired structural form with the structure having a closed-cell, compact array of bonded beads.

  12. High temperature structural insulating material

    DOE Patents [OSTI]

    Chen, Wayne Y.

    1987-01-01

    A high temperature structural insulating material useful as a liner for cylinders of high temperature engines through the favorable combination of high service temperature (above about 800.degree. C.), low thermal conductivity (below about 0.2 W/m.degree. C.), and high compressive strength (above about 250 psi). The insulating material is produced by selecting hollow ceramic beads with a softening temperature above about 800.degree. C., a diameter within the range of 20-200 .mu.m, and a wall thickness in the range of about 2-4 .mu.m; compacting the beads and a compatible silicate binder composition under pressure and sintering conditions to provide the desired structural form with the structure having a closed-cell, compact array of bonded beads.

  13. High-Level Waste Requirements

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1999-07-09

    The guide provides the criteria for determining which DOE radioactive wastes are to be managed as high-level waste in accordance with DOE M 435.1-1.

  14. High temperature current mirror amplifier

    DOE Patents [OSTI]

    Patterson, III, Raymond B. (Melbourne, FL)

    1984-05-22

    A high temperature current mirror amplifier having biasing means in the transdiode connection of the input transistor for producing a voltage to maintain the base-collector junction reversed-biased and a current means for maintaining a current through the biasing means at high temperatures so that the base-collector junction of the input transistor remained reversed-biased. For accuracy, a second current mirror is provided with a biasing means and current means on the input leg.

  15. High average power pockels cell

    DOE Patents [OSTI]

    Daly, Thomas P. (Pleasanton, CA)

    1991-01-01

    A high average power pockels cell is disclosed which reduces the effect of thermally induced strains in high average power laser technology. The pockels cell includes an elongated, substantially rectangular crystalline structure formed from a KDP-type material to eliminate shear strains. The X- and Y-axes are oriented substantially perpendicular to the edges of the crystal cross-section and to the C-axis direction of propagation to eliminate shear strains.

  16. Graphical and tabular summaries of decay characteristics for once-through PWR, LMFBR, and FFTF fuel cycle materials. [Spent fuel, high-level waste fuel can scrap

    SciTech Connect (OSTI)

    Croff, A.G.; Liberman, M.S.; Morrison, G.W.

    1982-01-01

    Based on the results of ORIGEN2 and a newly developed code called ORMANG, graphical and summary tabular characteristics of spent fuel, high-level waste, and fuel assembly structural material (cladding) waste are presented for a generic pressurized-water reactor (PWR), a liquid-metal fast breeder reactor (LMFBR), and the Fast Flux Test Facility (FFTF). The characteristics include radioactivity, thermal power, and toxicity (water dilution volume). Given are graphs and summary tables containing characteristic totals and the principal nuclide contributors as well as graphs comparing the three reactors for a single material and the three materials for a single reactor.

  17. High Flux Metallic Membranes for Hydrogen Recovery and Membrane Reactors

    SciTech Connect (OSTI)

    Buxbaum, Robert

    2010-06-30

    We made and tested over 250 new alloys for use as lower cost, higher flux hydrogen extraction membrane materials. Most of these were intermetallic, or contained significant intermetallic content, particularly based on B2 alloy compositions with at least one refractory component; B2 intermetallics resemble BCC alloys, in structure, but the atoms have relatively fixed positions, with one atom at the corners of the cube, the other at the centers. The target materals we were looking for would contain little or no expensive elements, no strongly toxic or radioactive elements, would have high flux to hydrogen, while being fabricable, brazable, and relatively immune to hydrogen embrittlement and corrosion in operation. The best combination of properties of the membrane materials we developed was, in my opinion, a Pd-coated membrane consisting of V -9 atomic % Pd. This material was relatively cheap, had 5 times the flux of Pd under the same pressure differential, was reasonably easy to fabricate and braze, and not bad in terms of embrittlement. Based on all these factors we project, about 1/3 the cost of Pd, on an area basis for a membrane designed to last 20 years, or 1/15 the cost on a flux basis. Alternatives to this membrane replaced significant fractions of the Pd with Ni and or Co. The cost for these membranes was lower, but so was the flux. We produced successful brazed products from the membrane materials, and made them into flat sheets. We tested, unsuccessfully, several means of fabricating thematerials into tubes, and eventually built a membrane reactor using a new, flat-plate design: a disc and doughnut arrangement, a design that seems well- suited to clean hydrogen production from coal. The membranes and reactor were tested successfully at Western Research. A larger equipment company (Chart Industries) produced similar results using a different flat-plate reactor design. Cost projections of the membrane are shown to be attractive.

  18. High resolution, high rate x-ray spectrometer

    DOE Patents [OSTI]

    Goulding, F.S.; Landis, D.A.

    1983-07-14

    It is an object of the invention to provide a pulse processing system for use with detected signals of a wide dynamic range which is capable of very high counting rates, with high throughput, with excellent energy resolution and a high signal-to-noise ratio. It is a further object to provide a pulse processing system wherein the fast channel resolving time is quite short and substantially independent of the energy of the detected signals. Another object is to provide a pulse processing system having a pile-up rejector circuit which will allow the maximum number of non-interfering pulses to be passed to the output. It is also an object of the invention to provide new methods for generating substantially symmetrically triangular pulses for use in both the main and fast channels of a pulse processing system.

  19. Extended length microchannels for high density high throughput electrophoresis systems

    DOE Patents [OSTI]

    Davidson, James C. (Livermore, CA); Balch, Joseph W. (Livermore, CA)

    2000-01-01

    High throughput electrophoresis systems which provide extended well-to-read distances on smaller substrates, thus compacting the overall systems. The electrophoresis systems utilize a high density array of microchannels for electrophoresis analysis with extended read lengths. The microchannel geometry can be used individually or in conjunction to increase the effective length of a separation channel while minimally impacting the packing density of channels. One embodiment uses sinusoidal microchannels, while another embodiment uses plural microchannels interconnected by a via. The extended channel systems can be applied to virtually any type of channel confined chromatography.

  20. High-Rate, High-Capacity Binder-Free Electrode

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Office of Energy Efficiency and Renewable Energy operated by the Alliance for Sustainable Energy, LLC High-Rate, High-Capacity Binder-Free Electrode Patent: PCT-09-41 Chunmei Ban Zhuangchun Wu Anne Dillon National Renewable Energy Laboratory PCT: 09-41 Binderfree electrode 2 Outline  What is the technology  Why it is better than other technologies  How far away from market  Technical details  Market analysis National Renewable Energy Laboratory PCT: 09-41 Binderfree electrode 3

  1. Final report on the developmental toxicity of ethylenediamine (CAS No. 107-15-3) in New Zealand white rabbits. Report for November-February 1992

    SciTech Connect (OSTI)

    Not Available

    1993-03-01

    Ethylenediamine (EDA) is a major industrial chemical with an estimated U.S. production of 64 million pounds in 1985. EDA is used as a chemical intermediate or solvent in manufacturing, as a paint thinner, and as a constituent of certain cosmetic, pharmaceutical and veterinary products. Based upon its widespread applications and the potential for exposure in pregnant women, EDA was evaluated for maternal and developmental toxicity using a laboratory animal model. Artificially-inseminated New Zealand White rabbits (26/group) were administered ethylenediamine (0, 10, 40 or 80 mg/kg/day) by gavage on gestational days (gd) 6 through 19. The doses administered were equivalent to 0, 22, 89 or 178 of EDA.2HC1. Maternal clinical signs, body weight, and food consumption were monitored at regular intervals throughout gestation. At termination (gd 30), the uterus was removed and examined to determine pregnancy status and to evaluate the number of resorptions, and dead or live fetuses. Dead or live fetuses were weighed, and live fetuses examined for external, visceral and skeletal defects.

  2. A CHRONIC INHALATION STUDY OF METHYL BROMIDE TOXICITY IN B6C3F1 MICE. (FINAL REPORT TO THE NATIONAL TOXICOLOGY PROGRAM)

    SciTech Connect (OSTI)

    HABER, S.B.

    1987-06-26

    This report provides a detailed account of a two year chronic inhalation study of methyl bromide toxicity in B6C3Fl mice conducted for the National Toxicology Program. Mice were randomized into three dose groups (10, 33 and 100 ppm methyl bromide) and one control group (0 ppm) per sex and exposed 5 days/week, 6 hours/day, for a total of 103 weeks. Endpoints included body weight; clinical signs and mortality, and at 6, 15 and 24 months of exposure, animals were sacrificed for organ weights, hematology and histopathology. In addition, a subgroup of animals in each dosage group was monitored for neurobehavioral and neuropathological changes. After only 20 weeks of exposure, 48% of the males and 12% of the females in the 100 ppm group had died. Exposures were terminated in that group and the surviving mice were observed for the duration of the study. Exposure of B6C3Fl mice to methyl bromide, even for only 20 weeks, produced significant changes in growth rate, mortality, organ weights and neurobehavioral functioning. These changes occurred in both males and females, but were more pronounced in males.

  3. Outcomes of High-Dose-Rate Interstitial Brachytherapy in the Treatment of Locally Advanced Cervical Cancer: Long-term Results

    SciTech Connect (OSTI)

    Pinn-Bingham, Melva; Puthawala, Ajmel A.; Syed, A.M. Nisar; Sharma, Anil; DiSaia, Philip; Berman, Michael; Tewari, Krishnansu S.; Randall-Whitis, Leslie; Mahmood, Usama; Ramsinghani, Nilam; Kuo, Jeffrey; Chen, Wen-Pin; McLaren, Christine E.

    2013-03-01

    Purpose: The purpose of this study was to determine locoregional control (LRC), disease-free survival (DFS), and toxicity of high-dose-rate interstitial brachytherapy (HDR-ISBT) in the treatment of locally advanced cervical cancer. Methods and Materials: Between March 1996 and May 2009, 116 patients with cervical cancer were treated. Of these, 106 (91%) patients had advanced disease (International Federation of Gynecology and Obstetrics stage IIB-IVA). Ten patients had stage IB, 48 had stage II, 51 had stage III, and 7 had stage IVA disease. All patients were treated with a combination of external beam radiation therapy (EBRT) to the pelvis (5040 cGy) and 2 applications of HDR-ISBT to a dose of 3600 cGy to the implanted volume. Sixty-one percent of patients also received interstitial hyperthermia, and 94 (81%) patients received chemotherapy. Results: Clinical LRC was achieved in 99 (85.3%) patients. Three-year DFS rates were 59%, 67%, 71%, and 57% for patients with stage IB, II, III, and IVA disease, respectively. The 5-year DFS and overall survival rates for the entire group were 60% and 44%, respectively. Acute and late toxicities were within acceptable limits. Conclusions: Locally advanced cervical cancer patients for whom intracavitary BT is unsuitable can achieve excellent LRC and OS with a combination of EBRT and HDR-ISBT.

  4. High resolution digital delay timer

    DOE Patents [OSTI]

    Martin, Albert D. (Los Alamos, NM)

    1988-01-01

    Method and apparatus are provided for generating an output pulse following a trigger pulse at a time delay interval preset with a resolution which is high relative to a low resolution available from supplied clock pulses. A first lumped constant delay (20) provides a first output signal (24) at predetermined interpolation intervals corresponding to the desired high resolution time interval. Latching circuits (26, 28) latch the high resolution data (24) to form a first synchronizing data set (60). A selected time interval has been preset to internal counters (142, 146, 154) and corrected for circuit propagation delay times having the same order of magnitude as the desired high resolution. Internal system clock pulses (32, 34) count down the counters to generate an internal pulse delayed by an interval which is functionally related to the preset time interval. A second LCD (184) corrects the internal signal with the high resolution time delay. A second internal pulse is then applied to a third LCD (74) to generate a second set of synchronizing data (76) which is complementary with the first set of synchronizing data (60) for presentation to logic circuits (64). The logic circuits (64) further delay the internal output signal (72) to obtain a proper phase relationship of an output signal (80) with the internal pulses (32, 34). The final delayed output signal (80) thereafter enables the output pulse generator (82) to produce the desired output pulse (84) at the preset time delay interval following input of the trigger pulse (10, 12).

  5. High Burnup Fuel Behavior Modeling

    SciTech Connect (OSTI)

    Jahingir, M.; Rand, R.; Stachowski, R.; Miles, B.; Kusagaya, K.

    2007-07-01

    This paper discusses the development and qualification of the PRIME03 code to address high burnup mechanisms and to improve uranium utilization in current and new reactor designs. Materials properties and behavioral models have been updated from previous thermal-mechanical codes to reflect the effects of burnup on fuel pellet thermal conductivity, Zircaloy creep, fuel pellet relocation, and fission gas release. These new models are based on results of in-pool and post irradiation examination (PIE) of commercial boiling water reactor (BWR) fuel rods at high burnup and results from international experimental programs. The new models incorporated into PRIME03 also address specific high burnup effects associated with formation of pellet rim porosity at high exposure. The PRIME03 code is qualified by comparison of predicted and measured fuel performance parameters for a large number of high, low, and moderate burnup test and commercial reactor rod. The extensive experimental qualification of the PRIME03 prediction capabilities confirms that it is a reliable best-estimate predictor of fuel rod thermal-mechanical performance over a wide range of design and operating conditions. (authors)

  6. Ultra High Temperature | Open Energy Information

    Open Energy Info (EERE)

    Ultra High Temperature Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Print PDF Sanyal Temperature Classification: Ultra High Temperature Dictionary.png Ultra High...

  7. Gasification of high ash, high ash fusion temperature bituminous coals

    DOE Patents [OSTI]

    Liu, Guohai; Vimalchand, Pannalal; Peng, WanWang

    2015-11-13

    This invention relates to gasification of high ash bituminous coals that have high ash fusion temperatures. The ash content can be in 15 to 45 weight percent range and ash fusion temperatures can be in 1150.degree. C. to 1500.degree. C. range as well as in excess of 1500.degree. C. In a preferred embodiment, such coals are dealt with a two stage gasification process--a relatively low temperature primary gasification step in a circulating fluidized bed transport gasifier followed by a high temperature partial oxidation step of residual char carbon and small quantities of tar. The system to process such coals further includes an internally circulating fluidized bed to effectively cool the high temperature syngas with the aid of an inert media and without the syngas contacting the heat transfer surfaces. A cyclone downstream of the syngas cooler, operating at relatively low temperatures, effectively reduces loading to a dust filtration unit. Nearly dust- and tar-free syngas for chemicals production or power generation and with over 90%, and preferably over about 98%, overall carbon conversion can be achieved with the preferred process, apparatus and methods outlined in this invention.

  8. High thermal conductivity connector having high electrical isolation

    DOE Patents [OSTI]

    Nieman, Ralph C. (Downers Grove, IL); Gonczy, John D. (Oak Lawn, IL); Nicol, Thomas H. (St. Charles, IL)

    1995-01-01

    A method and article for providing a low-thermal-resistance, high-electrical-isolation heat intercept connection. The connection method involves clamping, by thermal interference fit, an electrically isolating cylinder between an outer metallic ring and an inner metallic disk. The connection provides durable coupling of a heat sink and a heat source.

  9. Electrokinetic high pressure hydraulic system

    DOE Patents [OSTI]

    Paul, Phillip H.; Rakestraw, David J.; Arnold, Don W.; Hencken, Kenneth R.; Schoeniger, Joseph S.; Neyer, David W.

    2001-01-01

    An electrokinetic high pressure hydraulic pump for manipulating fluids in capillary-based systems. The pump uses electro-osmotic flow to provide a high pressure hydraulic system, having no moving mechanical parts, for pumping and/or compressing fluids, for providing valve means and means for opening and closing valves, for controlling fluid flow rate, and manipulating fluid flow generally and in capillary-based systems (Microsystems), in particular. The compact nature of the inventive high pressure hydraulic pump provides the ability to construct a micro-scale or capillary-based HPLC system that fulfills the desire for small sample quantity, low solvent consumption, improved efficiency, the ability to run samples in parallel, and field portability. Control of pressure and solvent flow rate is achieved by controlling the voltage applied to an electrokinetic pump.

  10. Electrokinetic high pressure hydraulic system

    DOE Patents [OSTI]

    Paul, Phillip H.; Rakestraw, David J.; Arnold, Don W.; Hencken, Kenneth R.; Schoeniger, Joseph S.; Neyer, David W.

    2003-06-03

    An electrokinetic high pressure hydraulic pump for manipulating fluids in capillary-based system. The pump uses electro-osmotic flow to provide a high pressure hydraulic system, having no moving mechanical parts, for pumping and/or compressing fluids, for providing valve means and means for opening and closing valves, for controlling fluid flow rate, and manipulating fluid flow generally and in capillary-based systems (microsystems), in particular. The compact nature of the inventive high pressure hydraulic pump provides the ability to construct a micro-scale or capillary-based HPLC system that fulfills the desire for small sample quantity, low solvent consumption, improved efficiency, the ability to run samples in parallel, and field portability. Control of pressure and solvent flow rate is achieved by controlling the voltage applied to an electrokinetic pump.

  11. High Exposure Facility Technical Description

    SciTech Connect (OSTI)

    Carter, Gregory L.; Stithem, Arthur R.; Murphy, Mark K.; Smith, Alex K.

    2008-02-12

    The High Exposure Facility is a collimated high-level gamma irradiator that is located in the basement of the 318 building. It was custom developed by PNNL back in 1982 to meet the needs for high range radiological instrument calibrations and dosimeter irradiations. At the time no commercially available product existed that could create exposure rates up to 20,000 R/h. This document is intended to pass on the design criteria that was employed to create this unique facility, while maintaining compliance with ANSI N543-1974, "General Safety Standard for Installations Using Non-Medical X-Ray and Sealed Gamma-Ray Sources, Energies up to 10 MeV."

  12. High elastic modulus polymer electrolytes

    DOE Patents [OSTI]

    Balsara, Nitash Pervez; Singh, Mohit; Eitouni, Hany Basam; Gomez, Enrique Daniel

    2013-10-22

    A polymer that combines high ionic conductivity with the structural properties required for Li electrode stability is useful as a solid phase electrolyte for high energy density, high cycle life batteries that do not suffer from failures due to side reactions and dendrite growth on the Li electrodes, and other potential applications. The polymer electrolyte includes a linear block copolymer having a conductive linear polymer block with a molecular weight of at least 5000 Daltons, a structural linear polymer block with an elastic modulus in excess of 1.times.10.sup.7 Pa and an ionic conductivity of at least 1.times.10.sup.-5 Scm.sup.-1. The electrolyte is made under dry conditions to achieve the noted characteristics.

  13. High pressure liquid level monitor

    DOE Patents [OSTI]

    Bean, Vern E. (Frederick, MD); Long, Frederick G. (Ijamsville, MD)

    1984-01-01

    A liquid level monitor for tracking the level of a coal slurry in a high-pressure vessel including a toroidal-shaped float with magnetically permeable bands thereon disposed within the vessel, two pairs of magnetic field generators and detectors disposed outside the vessel adjacent the top and bottom thereof and magnetically coupled to the magnetically permeable bands on the float, and signal processing circuitry for combining signals from the top and bottom detectors for generating a monotonically increasing analog control signal which is a function of liquid level. The control signal may be utilized to operate high-pressure control valves associated with processes in which the high-pressure vessel is used.

  14. INL High Performance Building Strategy

    SciTech Connect (OSTI)

    Jennifer D. Morton

    2010-02-01

    High performance buildings, also known as sustainable buildings and green buildings, are resource efficient structures that minimize the impact on the environment by using less energy and water, reduce solid waste and pollutants, and limit the depletion of natural resources while also providing a thermally and visually comfortable working environment that increases productivity for building occupants. As Idaho National Laboratory (INL) becomes the nations premier nuclear energy research laboratory, the physical infrastructure will be established to help accomplish this mission. This infrastructure, particularly the buildings, should incorporate high performance sustainable design features in order to be environmentally responsible and reflect an image of progressiveness and innovation to the public and prospective employees. Additionally, INL is a large consumer of energy that contributes to both carbon emissions and resource inefficiency. In the current climate of rising energy prices and political pressure for carbon reduction, this guide will help new construction project teams to design facilities that are sustainable and reduce energy costs, thereby reducing carbon emissions. With these concerns in mind, the recommendations described in the INL High Performance Building Strategy (previously called the INL Green Building Strategy) are intended to form the INL foundation for high performance building standards. This revised strategy incorporates the latest federal and DOE orders (Executive Order [EO] 13514, Federal Leadership in Environmental, Energy, and Economic Performance [2009], EO 13423, Strengthening Federal Environmental, Energy, and Transportation Management [2007], and DOE Order 430.2B, Departmental Energy, Renewable Energy, and Transportation Management [2008]), the latest guidelines, trends, and observations in high performance building construction, and the latest changes to the Leadership in Energy and Environmental Design (LEED) Green Building Rating System (LEED 2009). The document employs a two-level approach for high performance building at INL. The first level identifies the requirements of the Guiding Principles for Sustainable New Construction and Major Renovations, and the second level recommends which credits should be met when LEED Gold certification is required.

  15. High Performance Photovoltaic Project Overview

    SciTech Connect (OSTI)

    Symko-Davies, M.; McConnell, R.

    2005-01-01

    The High-Performance Photovoltaic (HiPerf PV) Project was initiated by the U.S. Department of Energy to substantially increase the viability of photovoltaics (PV) for cost-competitive applications so that PV can contribute significantly to our energy supply and environment in the 21st century. To accomplish this, the National Center for Photovoltaics (NCPV) directs in-house and subcontracted research in high-performance polycrystalline thin-film and multijunction concentrator devices. In this paper, we describe the recent research accomplishments in the in-house directed efforts and the research efforts under way in the subcontracted area.

  16. High energy overcurrent protective device

    DOE Patents [OSTI]

    Praeg, Walter F. (Palos Park, IL)

    1982-01-01

    Electrical loads connected to capacitance elements in high voltage direct current systems are protected from damage by capacitance discharge overcurrents by connecting between the capacitance element and the load, a longitudinal inductor comprising a bifilar winding wound about a magnetic core, which forms an incomplete magnetic circuit. A diode is connected across a portion of the bifilar winding which conducts a unidirectional current only. Energy discharged from the capacitance element is stored in the inductor and then dissipated in an L-R circuit including the diode and the coil winding. Multiple high voltage circuits having capacitance elements may be connected to loads through bifilar windings all wound about the aforementioned magnetic core.

  17. High temperature superconductor current leads

    DOE Patents [OSTI]

    Hull, John R. (Hinsdale, IL); Poeppel, Roger B. (Glen Ellyn, IL)

    1995-01-01

    An electrical lead having one end for connection to an apparatus in a cryogenic environment and the other end for connection to an apparatus outside the cryogenic environment. The electrical lead includes a high temperature superconductor wire and an electrically conductive material distributed therein, where the conductive material is present at the one end of the lead at a concentration in the range of from 0 to about 3% by volume, and at the other end of the lead at a concentration of less than about 20% by volume. Various embodiments are shown for groups of high temperature superconductor wires and sheaths.

  18. High ratio recirculating gas compressor

    DOE Patents [OSTI]

    Weinbrecht, J.F.

    1989-08-22

    A high ratio positive displacement recirculating rotary compressor is disclosed. The compressor includes an integral heat exchanger and recirculation conduits for returning cooled, high pressure discharge gas to the compressor housing to reducing heating of the compressor and enable higher pressure ratios to be sustained. The compressor features a recirculation system which results in continuous and uninterrupted flow of recirculation gas to the compressor with no direct leakage to either the discharge port or the intake port of the compressor, resulting in a capability of higher sustained pressure ratios without overheating of the compressor. 10 figs.

  19. Electrokinetic high pressure hydraulic system

    DOE Patents [OSTI]

    Paul, Phillip H. (Livermore, CA); Rakestraw, David J. (Fremont, CA)

    2000-01-01

    A compact high pressure hydraulic pump having no moving mechanical parts for converting electric potential to hydraulic force. The electrokinetic pump, which can generate hydraulic pressures greater than 2500 psi, can be employed to compress a fluid, either liquid or gas, and manipulate fluid flow. The pump is particularly useful for capillary-base systems. By combining the electrokinetic pump with a housing having chambers separated by a flexible member, fluid flow, including high pressure fluids, is controlled by the application of an electric potential, that can vary with time.

  20. High temperature superconductor current leads

    DOE Patents [OSTI]

    Hull, J.R.; Poeppel, R.B.

    1995-06-20

    An electrical lead is disclosed having one end for connection to an apparatus in a cryogenic environment and the other end for connection to an apparatus outside the cryogenic environment. The electrical lead includes a high temperature superconductor wire and an electrically conductive material distributed therein, where the conductive material is present at the one end of the lead at a concentration in the range of from 0 to about 3% by volume, and at the other end of the lead at a concentration of less than about 20% by volume. Various embodiments are shown for groups of high temperature superconductor wires and sheaths. 9 figs.

  1. High-Average Power Facilities

    SciTech Connect (OSTI)

    Dowell, David H.; Power, John G.; /Argonne

    2012-09-05

    There has been significant progress in the development of high-power facilities in recent years yet major challenges remain. The task of WG4 was to identify which facilities were capable of addressing the outstanding R&D issues presently preventing high-power operation. To this end, information from each of the facilities represented at the workshop was tabulated and the results are presented herein. A brief description of the major challenges is given, but the detailed elaboration can be found in the other three working group summaries.

  2. High temperature current mirror amplifier

    DOE Patents [OSTI]

    Patterson, R.B. III.

    1984-05-22

    Disclosed is a high temperature current mirror amplifier having biasing means in the transdiode connection of the input transistor for producing a voltage to maintain the base-collector junction reversed-biased and a current means for maintaining a current through the biasing means at high temperatures so that the base-collector junction of the input transistor remained reversed-biased. For accuracy, a second current mirror is provided with a biasing means and current means on the input leg. 2 figs.

  3. High ratio recirculating gas compressor

    DOE Patents [OSTI]

    Weinbrecht, John F. (601 Oakwood Pl., NE., Albuquerque, NM 87123)

    1989-01-01

    A high ratio positive displacement recirculating rotary compressor is disclosed. The compressor includes an integral heat exchanger and recirculation conduits for returning cooled, high pressure discharge gas to the compressor housing to reducing heating of the compressor and enable higher pressure ratios to be sustained. The compressor features a recirculation system which results in continuous and uninterrupted flow of recirculation gas to the compressor with no direct leakage to either the discharge port or the intake port of the compressor, resulting in a capability of higher sustained pressure ratios without overheating of the compressor.

  4. High loading uranium fuel plate

    DOE Patents [OSTI]

    Wiencek, Thomas C.; Domagala, Robert F.; Thresh, Henry R.

    1990-01-01

    Two embodiments of a high uranium fuel plate are disclosed which contain a meat comprising structured uranium compound confined between a pair of diffusion bonded ductile metal cladding plates uniformly covering the meat, the meat having a uniform high fuel loading comprising a content of uranium compound greater than about 45 Vol. % at a porosity not greater than about 10 Vol. %. In a first embodiment, the meat is a plurality of parallel wires of uranium compound. In a second embodiment, the meat is a dispersion compact containing uranium compound. The fuel plates are fabricated by a hot isostatic pressing process.

  5. Pressure Relief Devices for High-Pressure Gaseous Storage Systems: Applicability to Hydrogen Technology

    SciTech Connect (OSTI)

    Kostival, A.; Rivkin, C.; Buttner, W.; Burgess, R.

    2013-11-01

    Pressure relief devices (PRDs) are viewed as essential safety measures for high-pressure gas storage and distribution systems. These devices are used to prevent the over-pressurization of gas storage vessels and distribution equipment, except in the application of certain toxic gases. PRDs play a critical role in the implementation of most high-pressure gas storage systems and anyone working with these devices should understand their function so they can be designed, installed, and maintained properly to prevent any potentially dangerous or fatal incidents. As such, the intention of this report is to introduce the reader to the function of the common types of PRDs currently used in industry. Since high-pressure hydrogen gas storage systems are being developed to support the growing hydrogen energy infrastructure, several recent failure incidents, specifically involving hydrogen, will be examined to demonstrate the results and possible mechanisms of a device failure. The applicable codes and standards, developed to minimize the risk of failure for PRDs, will also be reviewed. Finally, because PRDs are a critical component for the development of a successful hydrogen energy infrastructure, important considerations for pressure relief devices applied in a hydrogen gas environment will be explored.

  6. Removing High Explosives from Groundwater

    Broader source: Energy.gov [DOE]

    LOS ALAMOS, N.M. – In an initiative supported by EM, Los Alamos National Laboratory’s Corrective Actions Program is addressing high explosive contamination in surface water and groundwater at a location this summer in the forests surrounding the laboratory.

  7. High-efficiency photovoltaic cells

    DOE Patents [OSTI]

    Yang, H.T.; Zehr, S.W.

    1982-06-21

    High efficiency solar converters comprised of a two cell, non-lattice matched, monolithic stacked semiconductor configuration using optimum pairs of cells having bandgaps in the range 1.6 to 1.7 eV and 0.95 to 1.1 eV, and a method of fabrication thereof, are disclosed. The high band gap subcells are fabricated using metal organic chemical vapor deposition (MOCVD), liquid phase epitaxy (LPE) or molecular beam epitaxy (MBE) to produce the required AlGaAs layers of optimized composition, thickness and doping to produce high performance, heteroface homojunction devices. The low bandgap subcells are similarly fabricated from AlGa(As)Sb compositions by LPE, MBE or MOCVD. These subcells are then coupled to form a monolithic structure by an appropriate bonding technique which also forms the required transparent intercell ohmic contact (IOC) between the two subcells. Improved ohmic contacts to the high bandgap semiconductor structure can be formed by vacuum evaporating to suitable metal or semiconductor materials which react during laser annealing to form a low bandgap semiconductor which provides a low contact resistance structure.

  8. High Impact Technology (HIT) Catalyst

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Impact Technology (HIT) Catalyst Images courtesy CREE, True Manufacturing, A.O. Smith, Bernstein Associates, Cambridge Engineering, Alliance Laundry Systems, NREL Commercial Buildings Integration Building Technologies Office 2 How can we catalyze the adoption of high impact commercial building technologies? Occupants Financial Institutions Government Utilities Scientists Manufacturers Dealers Suppliers Owners Stakeholder Engagement & Partnerships Managers Designers Engineers 3 Building

  9. High temperature turbine engine structure

    DOE Patents [OSTI]

    Boyd, Gary L. (Tempe, AZ)

    1990-01-01

    A high temperature turbine engine includes a hybrid ceramic/metallic rotor member having ceramic/metal joint structure. The disclosed joint is able to endure higher temperatures than previously possible, and aids in controlling heat transfer in the rotor member.

  10. High pressure neon arc lamp

    DOE Patents [OSTI]

    Sze, Robert C.; Bigio, Irving J.

    2003-07-15

    A high pressure neon arc lamp and method of using the same for photodynamic therapies is provided. The high pressure neon arc lamp includes a housing that encloses a quantity of neon gas pressurized to about 500 Torr to about 22,000 Torr. At each end of the housing the lamp is connected by electrodes and wires to a pulse generator. The pulse generator generates an initial pulse voltage to breakdown the impedance of the neon gas. Then the pulse generator delivers a current through the neon gas to create an electrical arc that emits light having wavelengths from about 620 nanometers to about 645 nanometers. A method for activating a photosensitizer is provided. Initially, a photosensitizer is administered to a patient and allowed time to be absorbed into target cells. Then the high pressure neon arc lamp is used to illuminate the target cells with red light having wavelengths from about 620 nanometers to about 645 nanometers. The red light activates the photosensitizers to start a chain reaction that may involve oxygen free radicals to destroy the target cells. In this manner, a high pressure neon arc lamp that is inexpensive and efficiently generates red light useful in photodynamic therapy is provided.

  11. High Performance Outdoor Lighting Accelerator

    Broader source: Energy.gov [DOE]

    Hosted by the U.S. Department of Energy (DOE)s Weatherization and Intergovernmental Programs Office (WIPO), this webinar covered the expansion of the Better Buildings platform to include the newest initiative for the public sector: the High Performance Outdoor Lighting Accelerator (HPOLA).

  12. High Performance Bulk Thermoelectric Materials

    SciTech Connect (OSTI)

    Ren, Zhifeng

    2013-03-31

    Over 13 plus years, we have carried out research on electron pairing symmetry of superconductors, growth and their field emission property studies on carbon nanotubes and semiconducting nanowires, high performance thermoelectric materials and other interesting materials. As a result of the research, we have published 104 papers, have educated six undergraduate students, twenty graduate students, nine postdocs, nine visitors, and one technician.

  13. High temperature turbine engine structure

    DOE Patents [OSTI]

    Boyd, Gary L. (Tempe, AZ)

    1991-01-01

    A high temperature turbine engine includes a rotor portion having axially stacked adjacent ceramic rotor parts. A ceramic/ceramic joint structure transmits torque between the rotor parts while maintaining coaxial alignment and axially spaced mutually parallel relation thereof despite thermal and centrifugal cycling.

  14. High precision redundant robotic manipulator

    DOE Patents [OSTI]

    Young, K.K.D.

    1998-09-22

    A high precision redundant robotic manipulator for overcoming contents imposed by obstacles or imposed by a highly congested work space is disclosed. One embodiment of the manipulator has four degrees of freedom and another embodiment has seven degrees of freedom. Each of the embodiments utilize a first selective compliant assembly robot arm (SCARA) configuration to provide high stiffness in the vertical plane, a second SCARA configuration to provide high stiffness in the horizontal plane. The seven degree of freedom embodiment also utilizes kinematic redundancy to provide the capability of avoiding obstacles that lie between the base of the manipulator and the end effector or link of the manipulator. These additional three degrees of freedom are added at the wrist link of the manipulator to provide pitch, yaw and roll. The seven degrees of freedom embodiment uses one revolute point per degree of freedom. For each of the revolute joints, a harmonic gear coupled to an electric motor is introduced, and together with properly designed based servo controllers provide an end point repeatability of less than 10 microns. 3 figs.

  15. High precision redundant robotic manipulator

    DOE Patents [OSTI]

    Young, Kar-Keung David (Mountain View, CA)

    1998-01-01

    A high precision redundant robotic manipulator for overcoming contents imposed by obstacles or imposed by a highly congested work space. One embodiment of the manipulator has four degrees of freedom and another embodiment has seven degreed of freedom. Each of the embodiments utilize a first selective compliant assembly robot arm (SCARA) configuration to provide high stiffness in the vertical plane, a second SCARA configuration to provide high stiffness in the horizontal plane. The seven degree of freedom embodiment also utilizes kinematic redundancy to provide the capability of avoiding obstacles that lie between the base of the manipulator and the end effector or link of the manipulator. These additional three degrees of freedom are added at the wrist link of the manipulator to provide pitch, yaw and roll. The seven degrees of freedom embodiment uses one revolute point per degree of freedom. For each of the revolute joints, a harmonic gear coupled to an electric motor is introduced, and together with properly designed based servo controllers provide an end point repeatability of less than 10 microns.

  16. Sandia National Laboratories: Research: High Consequence, Automation...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High-Consequence Automation Robotics Homepage About Robotics Research & Development Advanced Controls Advanced Manipulation Cybernetics High-Consequence Automation Demilitarization...

  17. Materials Characterization Capabilities at the High Temperature...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials Characterization Capabilities at the High Temperature Materials Laboratory: ... Success Stories from the High Temperature Materials Laboratory (HTML) User ...

  18. Materials Characterization Capabilities at the High Temperature...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials Characterization Capabilities at the High Temperature Materials Laboratory and ... Materials Characterization Capabilities at the High Temperature Materials Laboratory and ...

  19. High Impact Technology Catalyst: Technology Deployment Strategies...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Catalyst: Technology Deployment Strategies High Impact Technology Catalyst: Technology Deployment Strategies The Energy Department released the High Impact Technology Catalyst: ...

  20. High performance internal reforming unit for high temperature fuel cells

    DOE Patents [OSTI]

    Ma, Zhiwen (Sandy Hook, CT); Venkataraman, Ramakrishnan (New Milford, CT); Novacco, Lawrence J. (Brookfield, CT)

    2008-10-07

    A fuel reformer having an enclosure with first and second opposing surfaces, a sidewall connecting the first and second opposing surfaces and an inlet port and an outlet port in the sidewall. A plate assembly supporting a catalyst and baffles are also disposed in the enclosure. A main baffle extends into the enclosure from a point of the sidewall between the inlet and outlet ports. The main baffle cooperates with the enclosure and the plate assembly to establish a path for the flow of fuel gas through the reformer from the inlet port to the outlet port. At least a first directing baffle extends in the enclosure from one of the sidewall and the main baffle and cooperates with the plate assembly and the enclosure to alter the gas flow path. Desired graded catalyst loading pattern has been defined for optimized thermal management for the internal reforming high temperature fuel cells so as to achieve high cell performance.

  1. High energy resolution, high angular acceptance crystal monochromator

    DOE Patents [OSTI]

    Alp, Ercan E. (Bolingbrook, IL); Mooney, Timothy M. (Westmont, IL); Toellner, Thomas (Green Bay, WI)

    1996-06-04

    A 4-bounce dispersive crystal monochromator reduces the bandpass of synchrotron radiation to a 10-50 meV range without sacrificing angular acceptance. The monochromator includes the combination of an asymmetrical channel-cut single crystal of lower order reflection and a symmetrical channel-cut single crystal of higher order reflection in a nested geometric configuration. In the disclosed embodiment, a highly asymmetrically cut (.alpha.=20) outer silicon crystal (4 2 2) with low order reflection is combined with a symmetrically cut inner silicon crystal (10 6 4) with high order reflection to condition a hard x-ray component (5-30 keV) of synchrotron radiation down to the .mu.eV-neV level. Each of the crystals is coupled to the combination of a positioning inchworm and angle encoder via a respective rotation stage for accurate relative positioning of the crystals and precise energy tuning of the monochromator.

  2. High energy resolution, high angular acceptance crystal monochromator

    DOE Patents [OSTI]

    Alp, E.E.; Mooney, T.M.; Toellner, T.

    1996-06-04

    A 4-bounce dispersive crystal monochromator reduces the bandpass of synchrotron radiation to a 10-50 meV range without sacrificing angular acceptance. The monochromator includes the combination of an asymmetrical channel-cut single crystal of lower order reflection and a symmetrical channel-cut single crystal of higher order reflection in a nested geometric configuration. In the disclosed embodiment, a highly asymmetrically cut ({alpha}=20) outer silicon crystal (4 2 2) with low order reflection is combined with a symmetrically cut inner silicon crystal (10 6 4) with high order reflection to condition a hard x-ray component (5--30 keV) of synchrotron radiation down to the {micro}eV-neV level. Each of the crystals is coupled to the combination of a positioning inchworm and angle encoder via a respective rotation stage for accurate relative positioning of the crystals and precise energy tuning of the monochromator. 7 figs.

  3. High-sensitivity, high-speed continuous imaging system

    DOE Patents [OSTI]

    Watson, Scott A; Bender, III, Howard A

    2014-11-18

    A continuous imaging system for recording low levels of light typically extending over small distances with high-frame rates and with a large number of frames is described. Photodiode pixels disposed in an array having a chosen geometry, each pixel having a dedicated amplifier, analog-to-digital convertor, and memory, provide parallel operation of the system. When combined with a plurality of scintillators responsive to a selected source of radiation, in a scintillator array, the light from each scintillator being directed to a single corresponding photodiode in close proximity or lens-coupled thereto, embodiments of the present imaging system may provide images of x-ray, gamma ray, proton, and neutron sources with high efficiency.

  4. High power densities from high-temperature material interactions

    SciTech Connect (OSTI)

    Morris, J.F.

    1981-01-01

    Thermionic energy conversion (TEC) and metallic-fluid heat pipes (MFHPs) offer important and unique advantages in terrestrial and space energy processing. And they are well suited to serve together synergistically. TEC and MFHPs operate through working-fluid vaporization, condensation cycles that accept great thermal power densities at high temperatures. TEC and MFHPs have apparently simple, isolated performance mechanisms that are somewhat similar. And they also have obviously difficult, complected material problems that again are somewhat similar. Intensive investigation reveals that aspects of their operating cycles and material problems tend to merge: high-temperature material effects determine the level and lifetime of performance. Simplified equations verify the preceding statement for TEC and MFHPs. Material properties and interactions exert primary influences on operational effectiveness. And thermophysicochemical stabilities dictate operating temperatures which regulate the thermoemissive currents of TEC and the vaporization flow rates of MFHPs. Major high-temperature material problems of TEC and MFHPs have been solved. These solutions lead to productive, cost-effective applications of current TEC and MFHPs - and point to significant improvements with anticipated technological gains.

  5. Late Toxicity and Patient Self-Assessment of Breast Appearance/Satisfaction on RTOG 0319: A Phase 2 Trial of 3-Dimensional Conformal Radiation Therapy-Accelerated Partial Breast Irradiation Following Lumpectomy for Stages I and II Breast Cancer

    SciTech Connect (OSTI)

    Chafe, Susan; Moughan, Jennifer; McCormick, Beryl; Wong, John; Pass, Helen; Rabinovitch, Rachel; Arthur, Douglas W.; Petersen, Ivy; White, Julia; Vicini, Frank A.

    2013-08-01

    Purpose: Late toxicities and cosmetic analyses of patients treated with accelerated partial breast irradiation (APBI) on RTOG 0319 are presented. Methods and Materials: Patients with stages I to II breast cancer ?3 cm, negative margins, and ?3 positive nodes were eligible. Patients received three-dimensional conformal external beam radiation therapy (3D-CRT; 38.5 Gy in 10 fractions twice daily over 5 days). Toxicity and cosmesis were assessed by the patient (P), the radiation oncologist (RO), and the surgical oncologist (SO) at 3, 6, and 12 months from the completion of treatment and then annually. National Cancer Institute Common Terminology Criteria for Adverse Events, version 3.0, was used to grade toxicity. Results: Fifty-two patients were evaluable. Median follow-up was 5.3 years (range, 1.7-6.4 years). Eighty-two percent of patients rated their cosmesis as good/excellent at 1 year, with rates of 64% at 3 years. At 3 years, 31 patients were satisfied with the treatment, 5 were not satisfied but would choose 3D-CRT again, and none would choose standard radiation therapy. The worst adverse event (AE) per patient reported as definitely, probably, or possibly related to radiation therapy was 36.5% grade 1, 50% grade 2, and 5.8% grade 3 events. Grade 3 AEs were all skin or musculoskeletal-related. Treatment-related factors were evaluated to potentially establish an association with observed toxicity. Surgical bed volume, target volume, the number of beams used, and the use of bolus were not associated with late cosmesis. Conclusions: Most patients enrolled in RTOG 0319 were satisfied with their treatment, and all would choose to have the 3D-CRT APBI again.

  6. Ultrasonic Nakagami-parameter characterization of parotid-gland injury following head-and-neck radiotherapy: A feasibility study of late toxicity

    SciTech Connect (OSTI)

    Yang, Xiaofeng; Wu, Ning; Wang, Yuefeng; Tridandapani, Srini; School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332; Winship Cancer Institute, Emory University, Atlanta, Georgia 30322 ; Beitler, Jonathan J.; Yu, David S.; Curran, Walter J.; Liu, Tian; Bruner, Deborah W.; Winship Cancer Institute, Emory University, Atlanta, Georgia 30322; School of Nursing, Emory University, Atlanta, Georgia 30322

    2014-02-15

    Purpose: The study aims to investigate whether Nakagami parametersestimated from the statistical distribution of the backscattered ultrasound radio-frequency (RF) signalscould provide a means for quantitative characterization of parotid-gland injury resulting from head-and-neck radiotherapy. Methods: A preliminary clinical study was conducted with 12 postradiotherapy patients and 12 healthy volunteers. Each participant underwent one ultrasound study in which ultrasound scans were performed in the longitudinal, i.e., vertical orientation on the bilateral parotids. For the 12 patients, the mean radiation dose to the parotid glands was 37.7 9.5 Gy, and the mean follow-up time was 16.3 4.8 months. All enrolled patients experienced grade 1 or 2 late salivary-gland toxicity (RTOG/EORTC morbidity scale). The normal parotid glands served as the control group. The Nakagami-scaling and Nakagami-shape parameters were computed from the RF data to quantify radiation-induced parotid-gland changes. Results: Significant differences in Nakagami parameters were observed between the normal and postradiotherapy parotid glands. Compared with the control group, the Nakagami-scaling parameter of the postradiotherapy group decreased by 25.8% (p < 0.001), and the Nakagami-shape parameter decreased by 31.3% (p < 0.001). The area under the receiver operating characteristic curve was 0.85 for the Nakagami-scaling parameter and was 0.95 for the Nakagami-shape parameter, which further demonstrated the diagnostic efficiency of the Nakagami parameters. Conclusions: Nakagami parameters could be used to quantitatively measure parotid-gland injury following head-and-neck radiotherapy. Moreover, the clinical feasibility was demonstrated and this study provides meaningful preliminary data for future clinical investigation.

  7. Drug safety evaluation through biomarker analysis-A toxicity study in the cynomolgus monkey using an antibody-cytotoxic conjugate against ovarian cancer

    SciTech Connect (OSTI)

    Hsieh, Frank Y. Tengstrand, Elizabeth; Lee, J.-W.; Li, Lily Y.; Silverman, Lee; Riordan, Bill; Miwa, Gerald; Milton, Mark; Alden, Carl; Lee, Frank

    2007-10-01

    Antibody-cytotoxin conjugates are complex novel therapeutic agents whose toxicological properties are not presently well understood. The objective of this study was to identify serum biomarkers that correlate with MLN8866 (an Antibody-Cytotoxic Conjugate, mAb8866-CT) pathological events in monkeys and to predict the maximal tolerated dose (MTD) level using biomarkers. Cynomolgus monkeys were administered a single dose MLN8666 (5, 15 or 30 mg/kg) by intravenous infusion and evaluated over a 7-day period. Exposure levels were determined by quantifying MLN8866 levels (C{sub max} and AUC{sub 0-96h}) in serum. The increase in MLN8866 C{sub max} and AUC{sub 0-96h} was approximately dose proportional. Two biomarkers in serum (m/z 316 and m/z 368) were identified to be correlated with MLN8866 toxicological outcomes. The predicted MTD, 11.4 mg/kg, was within the MTD range set by pathology results (5-15 mg/kg). Administration of MLN8866 at 15 mg/kg and 30 mg/kg dose levels resulted in changes in hematology parameters associated with impaired hematopoiesis and bone marrow toxicity. The projected MLN8866 MTD exposure level was integrated with toxicokinetic analysis and showed C{sub max} = 236 {mu}g/mL and AUC{sub 0-96h} = 7246 h mg/mL. The safety of three different MLN8866 dosing regimens with three dosing schedules was explored with pharmacokinetic modeling.

  8. SU-E-T-501: Normal Tissue Toxicities of Pulsed Low Dose Rate Radiotherapy and Conventional Radiotherapy: An in Vivo Total Body Irradiation Study

    SciTech Connect (OSTI)

    Cvetkovic, D; Zhang, P; Wang, B; Chen, L; Ma, C

    2014-06-01

    Purpose: Pulsed low dose rate radiotherapy (PLDR) is a re-irradiation technique for therapy of recurrent cancers. We have previously shown a significant difference in the weight and survival time between the mice treated with conventional radiotherapy (CRT) and PLDR using total body irradiation (TBI). The purpose of this study was to investigate the in vivo effects of PLDR on normal mouse tissues.Materials and Methods: Twenty two male BALB/c nude mice, 4 months of age, were randomly assigned into a PLDR group (n=10), a CRT group (n=10), and a non-irradiated control group (n=2). The Siemens Artiste accelerator with 6 MV photon beams was used. The mice received a total of 18Gy in 3 fractions with a 20day interval. The CRT group received the 6Gy dose continuously at a dose rate of 300 MU/min. The PLDR group was irradiated with 0.2Gyx20 pulses with a 3min interval between the pulses. The mice were weighed thrice weekly and sacrificed 2 weeks after the last treatment. Brain, heart, lung, liver, spleen, gastrointestinal, urinary and reproductive organs, and sternal bone marrow were removed, formalin-fixed, paraffin-embedded and stained with H and E. Morphological changes were observed under a microscope. Results: Histopathological examination revealed atrophy in several irradiated organs. The degree of atrophy was mild to moderate in the PLDR group, but severe in the CRT group. The most pronounced morphological abnormalities were in the immune and hematopoietic systems, namely spleen and bone marrow. Brain hemorrhage was seen in the CRT group, but not in the PLDR group. Conclusions: Our results showed that PLDR induced less toxicity in the normal mouse tissues than conventional radiotherapy for the same dose and regimen. Considering that PLDR produces equivalent tumor control as conventional radiotherapy, it would be a good modality for treatment of recurrent cancers.

  9. Method for detecting toxic gases

    DOE Patents [OSTI]

    Stetter, Joseph R. (Naperville, IL); Zaromb, Solomon (Hinsdale, IL); Findlay, Jr., Melvin W. (Bolingbrook, IL)

    1991-01-01

    A method capable of detecting low concentrations of a pollutant or other component in air or other gas, utilizing a combination of a heating filament having a catalytic surface of a noble metal for exposure to the gas and producing a derivative chemical product from the component, and an electrochemical sensor responsive to the derivative chemical product for providing a signal indicative of the product. At concentrations in the order of about 1-100 ppm of tetrachloroethylene, neither the heating filament nor the electrochemical sensor is individually capable of sensing the pollutant. In the combination, the heating filament converts the benzyl chloride to one or more derivative chemical products which may be detected by the electrochemical sensor.

  10. Precombustion control of air toxics

    SciTech Connect (OSTI)

    Akers, D.J.; Harrison, C.; Nowak, M.; Toole-O`Neil, B.

    1996-12-31

    If regulation of hazardous air pollutant emissions from utility boilers occurs in the next few years, the least-cost, lowest-risk control method for many utilities is likely to be some form of coal cleaning. Approximately 75 percent of coal mined east of the Mississippi River is already cleaned before it is used by the electric utility industry. Current methods of coal cleaning reduce ash and sulfur content by removing ash-forming and sulfur-bearing minerals; these same methods have the capability to remove large amounts of most of the 14 elements named as hazardous air pollutants (HAPs) in Title III of the 1990 Amendments to the Clean Air Act.

  11. Method for detecting toxic gases

    DOE Patents [OSTI]

    Stetter, J.R.; Zaromb, S.; Findlay, M.W. Jr.

    1991-10-08

    A method is disclosed which is capable of detecting low concentrations of a pollutant or other component in air or other gas. This method utilizes a combination of a heating filament having a catalytic surface of a noble metal for exposure to the gas and producing a derivative chemical product from the component. An electrochemical sensor responds to the derivative chemical product for providing a signal indicative of the product. At concentrations in the order of about 1-100 ppm of tetrachloroethylene, neither the heating filament nor the electrochemical sensor is individually capable of sensing the pollutant. In the combination, the heating filament converts the benzyl chloride to one or more derivative chemical products which may be detected by the electrochemical sensor. 6 figures.

  12. High voltage photovoltaic power converter

    DOE Patents [OSTI]

    Haigh, Ronald E. (Arvada, CO); Wojtczuk, Steve (Cambridge, MA); Jacobson, Gerard F. (Livermore, CA); Hagans, Karla G. (Livermore, CA)

    2001-01-01

    An array of independently connected photovoltaic cells on a semi-insulating substrate contains reflective coatings between the cells to enhance efficiency. A uniform, flat top laser beam profile is illuminated upon the array to produce electrical current having high voltage. An essentially wireless system includes a laser energy source being fed through optic fiber and cast upon the photovoltaic cell array to prevent stray electrical signals prior to use of the current from the array. Direct bandgap, single crystal semiconductor materials, such as GaAs, are commonly used in the array. Useful applications of the system include locations where high voltages are provided to confined spaces such as in explosive detonation, accelerators, photo cathodes and medical appliances.

  13. High-temperature-measuring device

    DOE Patents [OSTI]

    Not Available

    1981-01-27

    A temperature measuring device for very high design temperatures (to 2000/sup 0/C) is described. The device comprises a homogenous base structure preferably in the form of a sphere or cylinder. The base structure contains a large number of individual walled cells. The base structure has a decreasing coefficient of elasticity within the temperature range being monitored. A predetermined quantity of inert gas is confined within each cell. The cells are dimensonally stable at the normal working temperature of the device. Increases in gaseous pressure within the cells will permanently deform the cell walls at temperatures within the high temperature range to be measured. Such deformation can be correlated to temperature by calibrating similarly constructed devices under known time and temperature conditions.

  14. High Temperature Heat Exchanger Project

    SciTech Connect (OSTI)

    Anthony E. Hechanova, Ph.D.

    2008-09-30

    The UNLV Research Foundation assembled a research consortium for high temperature heat exchanger design and materials compatibility and performance comprised of university and private industry partners under the auspices of the US DOE-NE Nuclear Hydrogen Initiative in October 2003. The objectives of the consortium were to conduct investigations of candidate materials for high temperature heat exchanger componets in hydrogen production processes and design and perform prototypical testing of heat exchangers. The initial research of the consortium focused on the intermediate heat exchanger (located between the nuclear reactor and hydrogen production plan) and the components for the hydrogen iodine decomposition process and sulfuric acid decomposition process. These heat exchanger components were deemed the most challenging from a materials performance and compatibility perspective

  15. Highly Oriented Crystals in Polythiophenes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Highly Oriented Crystals in Polythiophenes Conjugated polymers are being developed as the active semiconductor in devices such as light-emitting diodes, photovoltaic cells, and thin-film transistors (TFTs) for large-area and low-cost electronics. Vacuum deposited amorphous silicon is currently used in the TFTs that drive the active matrix liquid crystal displays (AM-LCDs) on laptops, computer monitors and televisions. TFTs are also used in disposable electronics such as radiofrequency

  16. High Flux Ti Nanofiltration Membrane

    Broader source: Energy.gov (indexed) [DOE]

    Susan MacKay, Ph.D., Cerahelix, Inc. U.S. DOE Advanced Manufacturing Office Program Review Meeting Washington, D.C. May 28-29, 2015 This presentation does not contain any proprietary, confidential, or otherwise restricted information. Project Objective To develop a ceramic filter that can separate complex mixtures at high temperature and low pH. Unique nanoscale features of the filter will enable it to perform faster, while using less energy and less pretreatment chemicals compared to competing

  17. High temperature turbine engine structure

    DOE Patents [OSTI]

    Carruthers, William D. (Mesa, AZ); Boyd, Gary L. (Tempe, AZ)

    1992-01-01

    A high temperature ceramic/metallic turbine engine includes a metallic housing which journals a rotor member of the turbine engine. A ceramic disk-like shroud portion of the engine is supported on the metallic housing portion and maintains a close running clearance with the rotor member. A ceramic spacer assembly maintains the close running clearance of the shroud portion and rotor member despite differential thermal movements between the shroud portion and metallic housing portion.

  18. High temperature turbine engine structure

    DOE Patents [OSTI]

    Carruthers, William D. (Mesa, AZ); Boyd, Gary L. (Tempe, AZ)

    1994-01-01

    A high temperature ceramic/metallic turbine engine includes a metallic housing which journals a rotor member of the turbine engine. A ceramic disk-like shroud portion of the engine is supported on the metallic housing portion and maintains a close running clearance with the rotor member. A ceramic spacer assembly maintains the close running clearance of the shroud portion and rotor member despite differential thermal movements between the shroud portion and metallic housing portion.

  19. High temperature turbine engine structure

    DOE Patents [OSTI]

    Carruthers, William D. (Mesa, AZ); Boyd, Gary L. (Tempe, AZ)

    1993-01-01

    A high temperature ceramic/metallic turbine engine includes a metallic housing which journals a rotor member of the turbine engine. A ceramic disk-like shroud portion of the engine is supported on the metallic housing portion and maintains a close running clearance with the rotor member. A ceramic spacer assembly maintains the close running clearance of the shroud portion and rotor member despite differential thermal movements between the shroud portion and metallic housing portion.

  20. High power gas laser amplifier

    DOE Patents [OSTI]

    Leland, Wallace T. (Los Alamos, NM); Stratton, Thomas F. (Los Alamos, NM)

    1981-01-01

    A high power output CO.sub.2 gas laser amplifier having a number of sections, each comprising a plurality of annular pumping chambers spaced around the circumference of a vacuum chamber containing a cold cathode, gridded electron gun. The electron beam from the electron gun ionizes the gas lasing medium in the sections. An input laser beam is split into a plurality of annular beams, each passing through the sections comprising one pumping chamber.

  1. Enabling High Efficiency Ethanol Engines

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Efficiency Ethanol Engines (VSSP 12) Presented by Robert Wagner Oak Ridge National Laboratory 2009 DOE Hydrogen Program and Vehicle Technologies Annual Merit Review This presentation does not contain any proprietary, confidential, or otherwise restricted information. May 20, 2009 Lee Slezak Vehicle Technologies U.S. Department of Energy David Smith Sentech Inc Keith Confer, John MacBain Delphi Automotive Systems Project ID: vssp_12_wagner 2 Managed by UT-Battelle for the U.S. Department of

  2. High-performance, high-volume fly ash concrete

    SciTech Connect (OSTI)

    2008-01-15

    This booklet offers the construction professional an in-depth description of the use of high-volume fly ash in concrete. Emphasis is placed on the need for increased utilization of coal-fired power plant byproducts in lieu of Portland cement materials to eliminate increased CO{sub 2} emissions during the production of cement. Also addressed is the dramatic increase in concrete performance with the use of 50+ percent fly ash volume. The booklet contains numerous color and black and white photos, charts of test results, mixtures and comparisons, and several HVFA case studies.

  3. Randomized Noninferiority Trial of Reduced High-Dose Volume Versus Standard Volume Radiation Therapy for Muscle-Invasive Bladder Cancer: Results of the BC2001 Trial (CRUK/01/004)

    SciTech Connect (OSTI)

    Huddart, Robert A.; Hall, Emma; Hussain, Syed A.; Jenkins, Peter; Rawlings, Christine; Tremlett, Jean; Crundwell, Malcolm; Adab, Fawzi A.; Sheehan, Denise; Syndikus, Isabel; Hendron, Carey; Lewis, Rebecca; Waters, Rachel; James, Nicholas D.

    2013-10-01

    Purpose: To test whether reducing radiation dose to uninvolved bladder while maintaining dose to the tumor would reduce side effects without impairing local control in the treatment of muscle-invasive bladder cancer. Methods and Materials: In this phase III multicenter trial, 219 patients were randomized to standard whole-bladder radiation therapy (sRT) or reduced high-dose volume radiation therapy (RHDVRT) that aimed to deliver full radiation dose to the tumor and 80% of maximum dose to the uninvolved bladder. Participants were also randomly assigned to receive radiation therapy alone or radiation therapy plus chemotherapy in a partial 2 2 factorial design. The primary endpoints for the radiation therapy volume comparison were late toxicity and time to locoregional recurrence (with a noninferiority margin of 10% at 2 years). Results: Overall incidence of late toxicity was less than predicted, with a cumulative 2-year Radiation Therapy Oncology Group grade 3/4 toxicity rate of 13% (95% confidence interval 8%, 20%) and no statistically significant differences between groups. The difference in 2-year locoregional recurrence free rate (RHDVRT ? sRT) was 6.4% (95% confidence interval ?7.3%, 16.8%) under an intention to treat analysis and 2.6% (?12.8%, 14.6%) in the per-protocol population. Conclusions: In this study RHDVRT did not result in a statistically significant reduction in late side effects compared with sRT, and noninferiority of locoregional control could not be concluded formally. However, overall low rates of clinically significant toxicity combined with low rates of invasive bladder cancer relapse confirm that (chemo)radiation therapy is a valid option for the treatment of muscle-invasive bladder cancer.

  4. High Efficiency Room Air Conditioner

    SciTech Connect (OSTI)

    Bansal, Pradeep

    2015-01-01

    This project was undertaken as a CRADA project between UT-Battelle and Geberal Electric Company and was funded by Department of Energy to design and develop of a high efficiency room air conditioner. A number of novel elements were investigated to improve the energy efficiency of a state-of-the-art WAC with base capacity of 10,000 BTU/h. One of the major modifications was made by downgrading its capacity from 10,000 BTU/hr to 8,000 BTU/hr by replacing the original compressor with a lower capacity (8,000 BTU/hr) but high efficiency compressor having an EER of 9.7 as compared with 9.3 of the original compressor. However, all heat exchangers from the original unit were retained to provide higher EER. The other subsequent major modifications included- (i) the AC fan motor was replaced by a brushless high efficiency ECM motor along with its fan housing, (ii) the capillary tube was replaced with a needle valve to better control the refrigerant flow and refrigerant set points, and (iii) the unit was tested with a drop-in environmentally friendly binary mixture of R32 (90% molar concentration)/R125 (10% molar concentration). The WAC was tested in the environmental chambers at ORNL as per the design rating conditions of AHAM/ASHRAE (Outdoor- 95F and 40%RH, Indoor- 80F, 51.5%RH). All these modifications resulted in enhancing the EER of the WAC by up to 25%.

  5. High Temperature Thermoelectric Materials Characterization for Automotive

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Waste Heat Recovery: Success Stories from the High Temperature Materials Laboratory (HTML) User Program | Department of Energy High Temperature Thermoelectric Materials Characterization for Automotive Waste Heat Recovery: Success Stories from the High Temperature Materials Laboratory (HTML) User Program High Temperature Thermoelectric Materials Characterization for Automotive Waste Heat Recovery: Success Stories from the High Temperature Materials Laboratory (HTML) User Program 2009 DOE

  6. High Temperature Superconductivity Partners | Department of Energy

    Office of Environmental Management (EM)

    High Temperature Superconductivity Partners High Temperature Superconductivity Partners Map showing DOE's partners/stakeholders in the High Temperature Superconductivity Program PDF icon High Temperature Superconductivity Partners More Documents & Publications DOE Superconductivity Program Stakeholders DOE Provides up to $51.8 Million to Modernize the U.S. Electric Grid System. June 27, 2007 High-Temperature Superconductivity Cable Demonstration Projects

  7. High flux solar energy transformation

    DOE Patents [OSTI]

    Winston, R.; Gleckman, P.L.; O'Gallagher, J.J.

    1991-04-09

    Disclosed are multi-stage systems for high flux transformation of solar energy allowing for uniform solar intensification by a factor of 60,000 suns or more. Preferred systems employ a focusing mirror as a primary concentrative device and a non-imaging concentrator as a secondary concentrative device with concentrative capacities of primary and secondary stages selected to provide for net solar flux intensification of greater than 2000 over 95 percent of the concentration area. Systems of the invention are readily applied as energy sources for laser pumping and in other photothermal energy utilization processes. 7 figures.

  8. High flux solar energy transformation

    DOE Patents [OSTI]

    Winston, Roland (Chicago, IL); Gleckman, Philip L. (Chicago, IL); O'Gallagher, Joseph J. (Flossmoor, IL)

    1991-04-09

    Disclosed are multi-stage systems for high flux transformation of solar energy allowing for uniform solar intensification by a factor of 60,000 suns or more. Preferred systems employ a focusing mirror as a primary concentrative device and a non-imaging concentrator as a secondary concentrative device with concentrative capacities of primary and secondary stages selected to provide for net solar flux intensification of greater than 2000 over 95 percent of the concentration area. Systems of the invention are readily applied as energy sources for laser pumping and in other photothermal energy utilization processes.

  9. High temperature sealed electrochemical cell

    DOE Patents [OSTI]

    Valentin Chung, Brice Hoani; Burke, Paul J.; Sadoway, Donald R.

    2015-10-06

    A cell for high temperature electrochemical reactions is provided. The cell includes a container, at least a portion of the container acting as a first electrode. An extension tube has a first end and a second end, the extension tube coupled to the container at the second end forming a conduit from the container to said first end. A second electrode is positioned in the container and extends out of the container via the conduit. A seal is positioned proximate the first end of the extension tube, for sealing the cell.

  10. High throughput protein production screening

    DOE Patents [OSTI]

    Beernink, Peter T.; Coleman, Matthew A.; Segelke, Brent W.

    2009-09-08

    Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic sequences, including human cDNAs using PCR and IVT methods and detecting the proteins through fluorescence or immunoblot techniques. This invention can be used to identify optimized PCR and WT conditions, codon usages and mutations. The methods are readily automated and can be used for high throughput analysis of protein expression levels, interactions, and functional states.

  11. High Intensity Polarized Electron Gun

    SciTech Connect (OSTI)

    Redwine, Robert P.

    2012-07-31

    The goal of the project was to investigate the possibility of building a very high intensity polarized electron gun for the Electron-Ion Collider. This development is crucial for the eRHIC project. The gun implements a large area cathode, ring-shaped laser beam and active cathode cooling. A polarized electron gun chamber with a large area cathode and active cathode cooling has been built and tested. A preparation chamber for cathode activation has been built and initial tests have been performed. Major parts for a load-lock chamber, where cathodes are loaded into the vacuum system, have been manufactured.

  12. High gas flow alpha detector

    DOE Patents [OSTI]

    Bolton, R.D.; Bounds, J.A.; Rawool-Sullivan, M.W.

    1996-05-07

    An alpha detector for application in areas of high velocity gas flows, such as smokestacks and air vents. A plurality of spaced apart signal collectors are placed inside an enclosure, which would include smokestacks and air vents, in sufficient numbers to substantially span said enclosure so that gas ions generated within the gas flow are electrostatically captured by the signal collector means. Electrometer means and a voltage source are connected to the signal collectors to generate an electrical field between adjacent signal collectors, and to indicate a current produced through collection of the gas ions by the signal collectors. 4 figs.

  13. High gas flow alpha detector

    DOE Patents [OSTI]

    Bolton, Richard D. (Los Alamos, NM); Bounds, John A. (Los Alamos, NM); Rawool-Sullivan, Mohini W. (Los Alamos, NM)

    1996-01-01

    An alpha detector for application in areas of high velocity gas flows, such as smokestacks and air vents. A plurality of spaced apart signal collectors are placed inside an enclosure, which would include smokestacks and air vents, in sufficient numbers to substantially span said enclosure so that gas ions generated within the gas flow are electrostatically captured by the signal collector means. Electrometer means and a voltage source are connected to the signal collectors to generate an electrical field between adjacent signal collectors, and to indicate a current produced through collection of the gas ions by the signal collectors.

  14. High voltage RF feedthrough bushing

    DOE Patents [OSTI]

    Grotz, Glenn F. (Huntington Station, NY)

    1984-01-01

    Described is a multi-element, high voltage radio frequency bushing for trmitting RF energy to an antenna located in a vacuum container. The bushing includes a center conductor of complex geometrical shape, an outer coaxial shield conductor, and a thin-walled hollow truncated cone insulator disposed between central and outer conductors. The shape of the center conductor, which includes a reverse curvature portion formed of a radially inwardly directed shoulder and a convex portion, controls the uniformity of the axial surface gradient on the insulator cone. The outer shield has a first substantially cylindrical portion and a second radially inwardly extending truncated cone portion.

  15. High-density fluid compositions

    SciTech Connect (OSTI)

    Sanders, D.C.

    1981-09-29

    Clear, high-density fluids suitable for use as well completion, packing, and perforation media comprise aqueous solutions of zinc bromide and calcium bromide having densities lying in the range of about 14.5 up to about 18.0 pounds per gallon and measured PH's lying in the range of about 3.5 up to about 6.0. Optionally, such fluids may also comprise calcium chloride and/or a soluble film-forming amine-based corrosion inhibitor. Such fluids under conditions of ordinary use exhibit low corrosion rates and have crystallization points lying well below the range of temperatures under which they are used.

  16. Electokinetic high pressure hydraulic system

    DOE Patents [OSTI]

    Paul, Phillip H. (Livermore, CA); Rakestraw, David J. (Fremont, CA)

    2000-01-01

    A compact high pressure hydraulic system having no moving parts for converting electric potential to hydraulic force and for manipulating fluids. Electro-osmotic flow is used to provide a valve and means to compress a fluid or gas in a capillary-based system. By electro-osmotically moving an electrolyte between a first position opening communication between a fluid inlet and outlet and a second position closing communication between the fluid inlet and outlet the system can be configured as a valve. The system can also be used to generate forces as large as 2500 psi that can be used to compress a fluid, either a liquid or a gas.

  17. Design of High Field Solenoids made of High Temperature Superconductors

    SciTech Connect (OSTI)

    Bartalesi, Antonio; /Pisa U.

    2010-12-01

    This thesis starts from the analytical mechanical analysis of a superconducting solenoid, loaded by self generated Lorentz forces. Also, a finite element model is proposed and verified with the analytical results. To study the anisotropic behavior of a coil made by layers of superconductor and insulation, a finite element meso-mechanic model is proposed and designed. The resulting material properties are then used in the main solenoid analysis. In parallel, design work is performed as well: an existing Insert Test Facility (ITF) is adapted and structurally verified to support a coil made of YBa{sub 2}Cu{sub 3}O{sub 7}, a High Temperature Superconductor (HTS). Finally, a technological winding process was proposed and the required tooling is designed.

  18. High-Temperature High-Efficiency Solar Thermoelectric Generators

    SciTech Connect (OSTI)

    Baranowski, LL; Warren, EL; Toberer, ES

    2014-03-01

    Inspired by recent high-efficiency thermoelectric modules, we consider thermoelectrics for terrestrial applications in concentrated solar thermoelectric generators (STEGs). The STEG is modeled as two subsystems: a TEG, and a solar absorber that efficiently captures the concentrated sunlight and limits radiative losses from the system. The TEG subsystem is modeled using thermoelectric compatibility theory; this model does not constrain the material properties to be constant with temperature. Considering a three-stage TEG based on current record modules, this model suggests that 18% efficiency could be experimentally expected with a temperature gradient of 1000A degrees C to 100A degrees C. Achieving 15% overall STEG efficiency thus requires an absorber efficiency above 85%, and we consider two methods to achieve this: solar-selective absorbers and thermally insulating cavities. When the TEG and absorber subsystem models are combined, we expect that the STEG modeled here could achieve 15% efficiency with optical concentration between 250 and 300 suns.

  19. Development of a high-throughput microfluidic integrated microarray for the detection of chimeric bioweapons.

    SciTech Connect (OSTI)

    Sheppod, Timothy; Satterfield, Brent; Hukari, Kyle W.; West, Jason A. A.; Hux, Gary A.

    2006-10-01

    The advancement of DNA cloning has significantly augmented the potential threat of a focused bioweapon assault, such as a terrorist attack. With current DNA cloning techniques, toxin genes from the most dangerous (but environmentally labile) bacterial or viral organism can now be selected and inserted into robust organism to produce an infinite number of deadly chimeric bioweapons. In order to neutralize such a threat, accurate detection of the expressed toxin genes, rather than classification on strain or genealogical decent of these organisms, is critical. The development of a high-throughput microarray approach will enable the detection of unknowns chimeric bioweapons. The development of a high-throughput microarray approach will enable the detection of unknown bioweapons. We have developed a unique microfluidic approach to capture and concentrate these threat genes (mRNA's) upto a 30 fold concentration. These captured oligonucleotides can then be used to synthesize in situ oligonucleotide copies (cDNA probes) of the captured genes. An integrated microfluidic architecture will enable us to control flows of reagents, perform clean-up steps and finally elute nanoliter volumes of synthesized oligonucleotides probes. The integrated approach has enabled a process where chimeric or conventional bioweapons can rapidly be identified based on their toxic function, rather than being restricted to information that may not identify the critical nature of the threat.

  20. Magnetic hydrogel with high coercivity

    SciTech Connect (OSTI)

    Szeri, H.; Alvero?lu, E.; Kurtan, U.; ?enel, M.; Baykal, A.

    2013-08-01

    Highlights: Polyacrylamide (PAAm) hydrogels containing magnetic BaFe{sub 12}O{sub 19} nanoparticles have been prepared. Magnetization measurements reveal that hydrogels have hard magnetic properties with high coercivity. Magnetic nanoparticles makes the gel more homogeneous and do not diffuse out of the gel during water intake. These gels are useful in applications as wastewater treatment once gels are magnetized before its usage. - Abstract: This study investigates the synthesis and characterization of polyacrylamide (PAAm) hydrogels containing magnetic BaFe{sub 12}O{sub 19} nanoparticles. Structural, electrical, and magnetic characterization of the gels have been performed with X-ray powder diffractometry, scanning electron microscopy, DC conductivity, magnetization and fluorescence spectroscopy techniques. The preparation and characterization of polyacrylamide (PAAm) hydrogels that contain 5 and 10 mg BaFe{sub 12}O{sub 19} (16 and 21 nm diameter) nanoparticles are described herein. It is seen from the fluorescence spectra that, nanoparticles surrounded to pyranine molecules so that some of pyranine molecules could not bound to the polymer strands. Electrical measurements show that presence of nanoparticles make the gel more homogeneous. Magnetization measurements reveal that hydrogels have hard magnetic properties with quite high coercivity of 4.2 kOe, which does not change with swelling. This feature makes these gels useful in applications as wastewater treatment if they are magnetized before use.