Sample records for high-throughput screening system

  1. Engineering of a High-Throughput Screening System to Identify Cellulosic Biomass,

    E-Print Network [OSTI]

    California at Riverside, University of

    - grated high-throughput (HTP) screening pipeline. Herein, we report on the engineering of a novel HTP

  2. High-throughput Microfluidic Screening Platforms for Microalgae Study 

    E-Print Network [OSTI]

    Kim, Hyun Soo

    2014-12-15T23:59:59.000Z

    parallel studies are needed, however, current microalgae culture systems are lack of high-throughput screening capabilities, and thus not suitable for the parallel studies. Here, three different high-throughput microfluidic microalgae screening platforms...

  3. High-throughput Microfluidic Screening Platforms for Microalgae Study

    E-Print Network [OSTI]

    Kim, Hyun Soo

    2014-12-15T23:59:59.000Z

    parallel studies are needed, however, current microalgae culture systems are lack of high-throughput screening capabilities, and thus not suitable for the parallel studies. Here, three different high-throughput microfluidic microalgae screening platforms...

  4. High-Throughput and Combinatorial Screening of Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-Throughput and Combinatorial Screening of Hydrogen Storage Materials (presentation) High-Throughput and Combinatorial Screening of Hydrogen Storage Materials (presentation)...

  5. High throughput protein production screening

    DOE Patents [OSTI]

    Beernink, Peter T. (Walnut Creek, CA); Coleman, Matthew A. (Oakland, CA); Segelke, Brent W. (San Ramon, CA)

    2009-09-08T23:59:59.000Z

    Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic sequences, including human cDNAs using PCR and IVT methods and detecting the proteins through fluorescence or immunoblot techniques. This invention can be used to identify optimized PCR and WT conditions, codon usages and mutations. The methods are readily automated and can be used for high throughput analysis of protein expression levels, interactions, and functional states.

  6. High Throughput/Combinatorial Screening of Hydrogen Storage Materials...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials: UOP Approaches High ThroughputCombinatorial Screening of Hydrogen Storage Materials: UOP Approaches Presentation by Adriaan Sachtler from the High Throughput...

  7. High Throughput/Combinatorial Screening of Hydrogen Storage Materials...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials (presentation) High ThroughputCombinatorial Screening of Hydrogen Storage Materials (presentation) Presented at the U.S. Department of Energy's Hydrogen Storage Meeting...

  8. High Throughput Combinatorial Screening of Biometic Metal-Organic...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Throughput Combinatorial Screening of Biometic Metal-Organic Materials for Military Hydrogen-Storage Materials (New Joint Miami UNREL DoDDLA Project) (presentation) High...

  9. Microfluidic Technologies for High-Throughput Screening Applications

    E-Print Network [OSTI]

    Quake, Stephen R.

    Microfluidic Technologies for High-Throughput Screening Applications Thesis by Todd Thorsen, patiently giving me advice on a large variety of subjects, ranging from microfluidics to optics of microfluidic devices for high-throughput screening applications, such as mutant enzyme libraries expressed

  10. Development and optimization of high-throughput zebrafish screening platform

    E-Print Network [OSTI]

    Koo, Bryan Kyo

    2010-01-01T23:59:59.000Z

    The high-throughput zebrafish screening platform is a revolutionary tool that enables subcellular precision in vivo whole animal screening of Danio Rerio. It can perform laser surgery and/or imaging in less than twenty ...

  11. ORIGINAL PAPER Propylene Epoxidation: High-Throughput Screening of Supported

    E-Print Network [OSTI]

    Senkan, Selim M.

    ORIGINAL PAPER Propylene Epoxidation: High-Throughput Screening of Supported Metal Catalysts of propylene using molecular oxygen was studied on a variety of supported metal catalysts. The most promising Propylene Á Epoxidation Á Sol­gel Á High-throughput 1 Introduction Propylene oxide (PO) is an important raw

  12. High throughput chemical munitions treatment system

    DOE Patents [OSTI]

    Haroldsen, Brent L. (Manteca, CA); Stofleth, Jerome H. (Albuquerque, NM); Didlake, Jr., John E. (Livermore, CA); Wu, Benjamin C-P (San Ramon, CA)

    2011-11-01T23:59:59.000Z

    A new High-Throughput Explosive Destruction System is disclosed. The new system is comprised of two side-by-side detonation containment vessels each comprising first and second halves that feed into a single agent treatment vessel. Both detonation containment vessels further comprise a surrounding ventilation facility. Moreover, the detonation containment vessels are designed to separate into two half-shells, wherein one shell can be moved axially away from the fixed, second half for ease of access and loading. The vessels are closed by means of a surrounding, clam-shell type locking seal mechanisms.

  13. Agenda from the U.S. Department of Energy's High Throughput Screening...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    from the U.S. Department of Energy's High Throughput Screening of Hydrogen Storage Materials Workshop on June 26, 2007 Agenda from the U.S. Department of Energy's High Throughput...

  14. High Throughput Pretreatment and Enzyme Hydrolysis of Biomass: Screening Recalcitrance in Large Sample Populations (Presentation)

    SciTech Connect (OSTI)

    Decker, S. R.

    2010-10-01T23:59:59.000Z

    Presentation on the execution of the first high-throughput thermochemical pretreatment/enzyme digestion pipeline for screening biomass for recalcitrance.

  15. Advances in High Throughput Screening of Biomass Recalcitrance (Poster)

    SciTech Connect (OSTI)

    Turner, G. B.; Decker, S. R.; Tucker, M. P.; Law, C.; Doeppke, C.; Sykes, R. W.; Davis, M. F.; Ziebell, A.

    2012-06-01T23:59:59.000Z

    This was a poster displayed at the Symposium. Advances on previous high throughput screening of biomass recalcitrance methods have resulted in improved conversion and replicate precision. Changes in plate reactor metallurgy, improved preparation of control biomass, species-specific pretreatment conditions, and enzymatic hydrolysis parameters have reduced overall coefficients of variation to an average of 6% for sample replicates. These method changes have improved plate-to-plate variation of control biomass recalcitrance and improved confidence in sugar release differences between samples. With smaller errors plant researchers can have a higher degree of assurance more low recalcitrance candidates can be identified. Significant changes in plate reactor, control biomass preparation, pretreatment conditions and enzyme have significantly reduced sample and control replicate variability. Reactor plate metallurgy significantly impacts sugar release aluminum leaching into reaction during pretreatment degrades sugars and inhibits enzyme activity. Removal of starch and extractives significantly decreases control biomass variability. New enzyme formulations give more consistent and higher conversion levels, however required re-optimization for switchgrass. Pretreatment time and temperature (severity) should be adjusted to specific biomass types i.e. woody vs. herbaceous. Desalting of enzyme preps to remove low molecular weight stabilizers and improved conversion levels likely due to water activity impacts on enzyme structure and substrate interactions not attempted here due to need to continually desalt and validate precise enzyme concentration and activity.

  16. Infrastructure to support ultra high throughput biodosimetry screening after a radiological event

    E-Print Network [OSTI]

    Brenner, David Jonathan

    GUY GARTY1 , ANDREW KARAM2 , & DAVID J. BRENNER3 1 Radiological Research Accelerator Facility, Radiological Research Accelerator Facility, Nevis Laboratories, Columbia UniverInfrastructure to support ultra high throughput biodosimetry screening after a radiological event

  17. Methods and technologies for high-throughput and high-content small animal screening

    E-Print Network [OSTI]

    Rohde, Christopher, 1979-

    2012-01-01T23:59:59.000Z

    High-throughput and high-content screening (HTS and HCS) of whole animals requires their immobilization for high-resolution imaging and manipulation. Here we present methods to enable HTS and HCS of the nematode Caenorhabditis ...

  18. On-chip sub-cellular resolution whole-animal manipulation for high-throughput in vivo screening

    E-Print Network [OSTI]

    Rohde, Christopher Benjamin

    We present a suite of technologies that can be combined to perform complex high-throughput whole-animal genetic and drug screens. When used in various combinations, these devices facilitate a variety of high-throughput ...

  19. High-Throughput and Combinatorial Screening of Hydrogen Storage...

    Broader source: Energy.gov (indexed) [DOE]

    groups at: U. Geneva (Switzerland), MPI (Germany), Stockholm University (Sweden), IFE (Norway), SRNL (USA), U. Tohoku, AIST (Japan) High-pressure Sintering Technique for Screening...

  20. High throughput solar cell ablation system

    DOE Patents [OSTI]

    Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John

    2012-09-11T23:59:59.000Z

    A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.

  1. High throughput solar cell ablation system

    DOE Patents [OSTI]

    Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John

    2014-10-14T23:59:59.000Z

    A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.

  2. High-Throughput Screening of Gene Function in Stem Cells Using Clonal Microarrays

    E-Print Network [OSTI]

    Schaffer, David V.

    High-Throughput Screening of Gene Function in Stem Cells Using Clonal Microarrays RANDOLPH S. ASHTON,a JOSEPH PELTIER,b CHRISTOPHER A. FASANO,c ANALEAH O'NEILL,b JOSHUA LEONARD,b SALLY TEMPLE,c DAVID. Sox2 transcription factor · Akt1 · Neural progenitor cells · Soft lithography ABSTRACT We describe

  3. Optical microplates for high-throughput screening of photosynthesis in lipid-producing algae{,

    E-Print Network [OSTI]

    Basu, Amar S.

    Optical microplates for high-throughput screening of photosynthesis in lipid- producing algae-producing algae of interest in 2nd generation biofuels. By conducting 96 experiments in parallel, photoirradiance the study of photosynthesis in algae. Societal challenges in energy sustainability have renewed interest

  4. Droplet microfluidic technology for single-cell high-throughput screening

    E-Print Network [OSTI]

    Perrimon, Norbert

    Droplet microfluidic technology for single-cell high-throughput screening Eric Brouzesa,b,1 (received for review March 31, 2009) We present a droplet-based microfluidic technology that enables high our droplet microfluidic platform is modular, robust, uses no moving parts, and has a wide range

  5. Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening

    SciTech Connect (OSTI)

    Cuttitta, Christina M. [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); The City University of New York, 2800 Victory Boulevard, Staten Island, NY 10314 (United States); Ericson, Daniel L. [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); University at Buffalo, SUNY, 12 Capen Hall, Buffalo, NY 14260 (United States); Scalia, Alexander [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Binghamton University, 4400 Vestal Parkway East, Binghamton, NY 11973-5000 (United States); Roessler, Christian G. [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Teplitsky, Ella [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Stony Brook University, Stony Brook, NY 11794-5215 (United States); Joshi, Karan [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); PEC University of Technology, Chandigarh (India); Campos, Olven [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33414 (United States); Agarwal, Rakhi; Allaire, Marc [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Orville, Allen M. [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Sweet, Robert M.; Soares, Alexei S., E-mail: soares@bnl.gov [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States)

    2015-01-01T23:59:59.000Z

    An acoustic high-throughput screening method is described for harvesting protein crystals and combining the protein crystals with chemicals such as a fragment library. Acoustic droplet ejection (ADE) is an emerging technology with broad applications in serial crystallography such as growing, improving and manipulating protein crystals. One application of this technology is to gently transfer crystals onto MiTeGen micromeshes with minimal solvent. Once mounted on a micromesh, each crystal can be combined with different chemicals such as crystal-improving additives or a fragment library. Acoustic crystal mounting is fast (2.33 transfers s{sup ?1}) and all transfers occur in a sealed environment that is in vapor equilibrium with the mother liquor. Here, a system is presented to retain crystals near the ejection point and away from the inaccessible dead volume at the bottom of the well by placing the crystals on a concave agarose pedestal (CAP) with the same chemical composition as the crystal mother liquor. The bowl-shaped CAP is impenetrable to crystals. Consequently, gravity will gently move the crystals into the optimal location for acoustic ejection. It is demonstrated that an agarose pedestal of this type is compatible with most commercially available crystallization conditions and that protein crystals are readily transferred from the agarose pedestal onto micromeshes with no loss in diffraction quality. It is also shown that crystals can be grown directly on CAPs, which avoids the need to transfer the crystals from the hanging drop to a CAP. This technology has been used to combine thermolysin and lysozyme crystals with an assortment of anomalously scattering heavy atoms. The results point towards a fast nanolitre method for crystal mounting and high-throughput screening.

  6. High-throughput method for optimum solubility screening for homogeneity and crystallization of proteins

    DOE Patents [OSTI]

    Kim, Sung-Hou (Moraga, CA); Kim, Rosalind (Moraga, CA); Jancarik, Jamila (Walnut Creek, CA)

    2012-01-31T23:59:59.000Z

    An optimum solubility screen in which a panel of buffers and many additives are provided in order to obtain the most homogeneous and monodisperse protein condition for protein crystallization. The present methods are useful for proteins that aggregate and cannot be concentrated prior to setting up crystallization screens. A high-throughput method using the hanging-drop method and vapor diffusion equilibrium and a panel of twenty-four buffers is further provided. Using the present methods, 14 poorly behaving proteins have been screened, resulting in 11 of the proteins having highly improved dynamic light scattering results allowing concentration of the proteins, and 9 were crystallized.

  7. Applications of Artificial Neural Networks and Fuzzy Models in High Throughput Screening: Classifying the activities of various compounds towards Cobalt

    E-Print Network [OSTI]

    Kansas, University of

    Applications of Artificial Neural Networks and Fuzzy Models in High Throughput Screening to the existing HTS method, via Quantitative Structure-Activity Relationship (QSAR) using Artificial Neural in solving non-linear pattern classification problems, we propose several different models of neural networks

  8. The Materials genome : rapid materials screening for renewable energy using high-throughput density functional theory

    E-Print Network [OSTI]

    Jain, Anubhav, Ph.D. Massachusetts Institute of Technology

    2011-01-01T23:59:59.000Z

    This thesis relates to the emerging field of high-throughput density functional theory (DFT) computation for materials design and optimization. Although highthroughput DFT is a promising new method for materials discovery, ...

  9. On-chip whole-animal manipulation for high-throughput subcellular-resolution in-vivo drug/genetic screening

    E-Print Network [OSTI]

    Yanik, Mehmet Fatih

    Techniques for rapid and automated small-animal manipulation and immobilization are necessary for high-throughput in vivo genetic/drug screens using cellular and sub-cellular features in multicellular organisms. We present ...

  10. Constant pressure high throughput membrane permeation testing system

    DOE Patents [OSTI]

    Albenze, Erik J.; Hopkinson, David P.; Luebke, David R.

    2014-09-02T23:59:59.000Z

    The disclosure relates to a membrane testing system for individual evaluation of a plurality of planar membranes subjected to a feed gas on one side and a sweep gas on a second side. The membrane testing system provides a pressurized flow of a feed and sweep gas to each membrane testing cell in a plurality of membrane testing cells while a stream of retentate gas from each membrane testing cell is ported by a retentate multiport valve for sampling or venting, and a stream of permeate gas from each membrane testing cell is ported by a permeate multiport valve for sampling or venting. Back pressure regulators and mass flow controllers act to maintain substantially equivalent gas pressures and flow rates on each side of the planar membrane throughout a sampling cycle. A digital controller may be utilized to position the retentate and permeate multiport valves cyclically, allowing for gas sampling of different membrane cells over an extended period of time.

  11. High Throughput Sample Preparation and Analysis for DNA Sequencing, PCR and Combinatorial Screening of Catalysis Based on Capillary Array Technique

    SciTech Connect (OSTI)

    Yonghua Zhang

    2002-05-27T23:59:59.000Z

    Sample preparation has been one of the major bottlenecks for many high throughput analyses. The purpose of this research was to develop new sample preparation and integration approach for DNA sequencing, PCR based DNA analysis and combinatorial screening of homogeneous catalysis based on multiplexed capillary electrophoresis with laser induced fluorescence or imaging UV absorption detection. The author first introduced a method to integrate the front-end tasks to DNA capillary-array sequencers. protocols for directly sequencing the plasmids from a single bacterial colony in fused-silica capillaries were developed. After the colony was picked, lysis was accomplished in situ in the plastic sample tube using either a thermocycler or heating block. Upon heating, the plasmids were released while chromsomal DNA and membrane proteins were denatured and precipitated to the bottom of the tube. After adding enzyme and Sanger reagents, the resulting solution was aspirated into the reaction capillaries by a syringe pump, and cycle sequencing was initiated. No deleterious effect upon the reaction efficiency, the on-line purification system, or the capillary electrophoresis separation was observed, even though the crude lysate was used as the template. Multiplexed on-line DNA sequencing data from 8 parallel channels allowed base calling up to 620 bp with an accuracy of 98%. The entire system can be automatically regenerated for repeated operation. For PCR based DNA analysis, they demonstrated that capillary electrophoresis with UV detection can be used for DNA analysis starting from clinical sample without purification. After PCR reaction using cheek cell, blood or HIV-1 gag DNA, the reaction mixtures was injected into the capillary either on-line or off-line by base stacking. The protocol was also applied to capillary array electrophoresis. The use of cheaper detection, and the elimination of purification of DNA sample before or after PCR reaction, will make this approach an attractive alternative to current methods for genetic analysis and disease diagnosis.

  12. automated high-throughput screening: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    requires rapid screening methods.3 One powerful is a powerful tool for functional genomics research and is also discussed as a potential therapeutic strategy.6 Quake, Stephen...

  13. Getter sputtering system for high-throughput fabrication of composition spreads

    SciTech Connect (OSTI)

    Gregoire, John M.; Dover, R. B. van; Jin Jing; Di Salvo, Francis J.; Abruna, Hector D. [Department of Physics, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States); Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States); Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States)

    2007-07-15T23:59:59.000Z

    We describe a sputtering system that can deposit composition spreads in an effectively UHV environment but which does not require the high-throughput paradigm to be compromised by a long pump down each time a target is changed. The system deploys four magnetron sputter guns in a cryoshroud (getter sputtering) which allows elements such as Ti and Zr to be deposited with minimal contamination by oxygen or other reactive background gases. The system also relies on custom substrate heaters to give rapid heating and cool down. The effectiveness of the gettering technique is evaluated, and example results obtained for catalytic activity of a pseudoternary composition spread are presented.

  14. High-throughput screening of shape memory alloy thin-film spreads using nanoindentation

    E-Print Network [OSTI]

    Rubloff, Gary W.

    -film libraries. Nanoindentation was performed on Ni­Mn­Al ternary composition spreads. The indentation hardness and Wyrobek3 recently set forth a series of guidelines for the use of a nanoindenter to screen combina- torial

  15. High-Throughput Assay of 9 Lysosomal Enzymes for Newborn Screening

    E-Print Network [OSTI]

    Gelb, Michael

    : There is interest in newborn screening of lysosomal storage diseases (LSDs) because of the avail- ability with a cassette of substrates and internal standards and 1 or 2 punches of a dried blood spot (DBS) from a newborn used for MS/MS quantification in the selected reaction monitoring mode. RESULTS: Analysis of blood

  16. A General Framework for Development and Data Analysis of Competitive High-Throughput Screens for Small-Molecule Inhibitors of Protein-Protein

    E-Print Network [OSTI]

    ). Recent advances in chemical biology and high-throughput (HTP)1 screening (13-15) have introduced the use sensitive, robust, and widely used HTP methods for the study of protein interactions and drug discovery (19, can serve as a sensitive molecular sensor. HTP FP assays usually detect changes in polarization caused

  17. Integrated microfluidic device for single-cell high throughput screening in dynamic gene expression analysis

    E-Print Network [OSTI]

    Hui, Lawrence Kwan Yeung

    2008-01-01T23:59:59.000Z

    P.J. , & Lee, L.P. , Microfluidics-based systems biology.T.M. & Quake, S.R. , Microfluidics: Fluid physics at theand applications of microfluidics in biology. Annu Rev

  18. Development of High-Throughput Microfluidic Impedance Spectroscopy Platform for Analyzing Microdroplets in Droplet Microfluidic System 

    E-Print Network [OSTI]

    Sobahi, Nebras MohammedKamal A.

    2014-07-22T23:59:59.000Z

    This thesis presents the development of a high-throughput microfluidic impedance spectroscopy platform for electrically detecting analyzing impedance measurements of non-contact and label free microdroplets. This microfluidic impedance spectroscopy...

  19. Development of High-Throughput Microfluidic Impedance Spectroscopy Platform for Analyzing Microdroplets in Droplet Microfluidic System

    E-Print Network [OSTI]

    Sobahi, Nebras MohammedKamal A.

    2014-07-22T23:59:59.000Z

    This thesis presents the development of a high-throughput microfluidic impedance spectroscopy platform for electrically detecting analyzing impedance measurements of non-contact and label free microdroplets. This microfluidic impedance spectroscopy...

  20. Integrated Controlling System and Unified Database for High Throughput Protein Crystallography Experiments

    SciTech Connect (OSTI)

    Gaponov, Yu.A.; Igarashi, N.; Hiraki, M.; Sasajima, K.; Matsugaki, N.; Suzuki, M.; Kosuge, T.; Wakatsuki, S. [Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba (Japan)

    2004-05-12T23:59:59.000Z

    An integrated controlling system and a unified database for high throughput protein crystallography experiments have been developed. Main features of protein crystallography experiments (purification, crystallization, crystal harvesting, data collection, data processing) were integrated into the software under development. All information necessary to perform protein crystallography experiments is stored (except raw X-ray data that are stored in a central data server) in a MySQL relational database. The database contains four mutually linked hierarchical trees describing protein crystals, data collection of protein crystal and experimental data processing. A database editor was designed and developed. The editor supports basic database functions to view, create, modify and delete user records in the database. Two search engines were realized: direct search of necessary information in the database and object oriented search. The system is based on TCP/IP secure UNIX sockets with four predefined sending and receiving behaviors, which support communications between all connected servers and clients with remote control functions (creating and modifying data for experimental conditions, data acquisition, viewing experimental data, and performing data processing). Two secure login schemes were designed and developed: a direct method (using the developed Linux clients with secure connection) and an indirect method (using the secure SSL connection using secure X11 support from any operating system with X-terminal and SSH support). A part of the system has been implemented on a new MAD beam line, NW12, at the Photon Factory Advanced Ring for general user experiments.

  1. Automated high-throughput flow-through real-time diagnostic system

    DOE Patents [OSTI]

    Regan, John Frederick

    2012-10-30T23:59:59.000Z

    An automated real-time flow-through system capable of processing multiple samples in an asynchronous, simultaneous, and parallel fashion for nucleic acid extraction and purification, followed by assay assembly, genetic amplification, multiplex detection, analysis, and decontamination. The system is able to hold and access an unlimited number of fluorescent reagents that may be used to screen samples for the presence of specific sequences. The apparatus works by associating extracted and purified sample with a series of reagent plugs that have been formed in a flow channel and delivered to a flow-through real-time amplification detector that has a multiplicity of optical windows, to which the sample-reagent plugs are placed in an operative position. The diagnostic apparatus includes sample multi-position valves, a master sample multi-position valve, a master reagent multi-position valve, reagent multi-position valves, and an optical amplification/detection system.

  2. Development of High-throughput and Robust Microfluidic Live Cell Assay Platforms for Combination Drug and Toxin Screening

    E-Print Network [OSTI]

    Wang, Han

    2012-02-14T23:59:59.000Z

    the labor-intensive and time-consuming limitations, they are too costly for general users. Microfluidic live cell screening platforms can allow precise control of cell culture microenvironments by applying accurate doses of biomolecular mixtures...

  3. High-Throughput/Combinatorial Techniques in Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    with a High Binding Energy (New Joint UC-BerkeleySymyx DoDDLA Project), Jeffrey Long, University of California, Berkeley High ThroughputCombinatorial Screening of Hydrogen...

  4. The Development of Microfabricated Microbial Fuel Cell Array as a High Throughput Screening Platform for Electrochemically Active Microbes 

    E-Print Network [OSTI]

    Hou, Huijie

    2012-02-14T23:59:59.000Z

    special thank you to Dr. Lei Li for her guidance and friendship. I am very grateful to learn not only microbiology, but also a serious research attitude from her. I thank all our group members in the NanoBio Systems lab for their support, help... .................................................................. 27 3.2.3 Assembly of the MFC array system ...................................................... 31 3.2.4 Data acquisition system and MFC array characterization ..................... 33 3.2.5 Conventional H-type MFC validation...

  5. HiTSEE: A Visualization Tool for Hit Selection and Analysis in High-Throughput Screening Experiments

    E-Print Network [OSTI]

    Deussen, Oliver

    importantly the lack of temporal control required to study dynamic processes, since a protein cannot be turned a cellular system and to elucidate the function of proteins. As genes encode proteins, gene function can be modu- lated through a mutation, which in turn perturbs the function of the protein of interest

  6. Design and fabrication of a microfluidies gradient generator system for high-throughput molecular interaction studies

    E-Print Network [OSTI]

    Chen, Guan-Jong, 1981-

    2004-01-01T23:59:59.000Z

    Design and fabrication of a microfluidics system capable of generating reproducible and controlled micro-biochemical environments that can be used as a diagnostic assay and microreactor is important. Here, a simple technique ...

  7. Improving the Yeast Three-Hybrid System for High-Throughput Target Discovery

    E-Print Network [OSTI]

    Bailey, Kyle

    2011-05-27T23:59:59.000Z

    fluorescence produced with only the yEGFP reporter (light gray) and maximal fluorescence with reporter activated by a LexA-B42 fusion (dark gray). Taken with permission from (Clark, D. D.; Peterson, B. R. Chembiochem 2005, 6, 1442). ............ 28 Figure 2... of induced yeast lacking LexA-B42 (red histogram). C) Table of relevant statistics taken from histograms. The median signal and coefficient of variation (CV) is taken from the gated population of induced cells bearing the complete system (black histogram...

  8. Applied Catalysis A: General 254 (2003) 97106 Photoionization detection (PID) as a high throughput

    E-Print Network [OSTI]

    Senkan, Selim M.

    Applied Catalysis A: General 254 (2003) 97­106 Photoionization detection (PID) as a high throughput 2002 Abstract A versatile photoionization detection (PID) system has been developed to rapidly screen libraries of catalytic materials. The PID approach involves the use of an appropriately selected dc

  9. High throughput optical scanner

    DOE Patents [OSTI]

    Basiji, David A. (Seattle, WA); van den Engh, Gerrit J. (Seattle, WA)

    2001-01-01T23:59:59.000Z

    A scanning apparatus is provided to obtain automated, rapid and sensitive scanning of substrate fluorescence, optical density or phosphorescence. The scanner uses a constant path length optical train, which enables the combination of a moving beam for high speed scanning with phase-sensitive detection for noise reduction, comprising a light source, a scanning mirror to receive light from the light source and sweep it across a steering mirror, a steering mirror to receive light from the scanning mirror and reflect it to the substrate, whereby it is swept across the substrate along a scan arc, and a photodetector to receive emitted or scattered light from the substrate, wherein the optical path length from the light source to the photodetector is substantially constant throughout the sweep across the substrate. The optical train can further include a waveguide or mirror to collect emitted or scattered light from the substrate and direct it to the photodetector. For phase-sensitive detection the light source is intensity modulated and the detector is connected to phase-sensitive detection electronics. A scanner using a substrate translator is also provided. For two dimensional imaging the substrate is translated in one dimension while the scanning mirror scans the beam in a second dimension. For a high throughput scanner, stacks of substrates are loaded onto a conveyor belt from a tray feeder.

  10. automating high-throughput blast: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to electron transfer dissoci- ation (ETD) mass spectrometry Shorter, James 15 Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium...

  11. automated high-throughput cultivations: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to electron transfer dissoci- ation (ETD) mass spectrometry Shorter, James 15 Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium...

  12. A GPU-INSPIRED SOFT PROCESSOR FOR HIGH-THROUGHPUT ACCELERATION

    E-Print Network [OSTI]

    Steffan, J. Gregory

    Methodology 35 6.1 System Simulation . . . . . . . A GPU-INSPIRED SOFT PROCESSOR FOR HIGH-THROUGHPUT ACCELERATION by Jeffrey Richard Code Kingyens Code Kingyens #12;Abstract A GPU-Inspired Soft Processor for High-Throughput Acceleration Jeffrey

  13. Vehicle Technologies Office Merit Review 2015: High-Throughput Study of Diffusion and Phase Transformation Kinetics of Magnesium-Based Systems For Automotive Cast Magnesium Alloys

    Broader source: Energy.gov [DOE]

    Presentation given by Ohio State University at 2015 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting about high-throughput study...

  14. Robofurnace: A semi-automated laboratory chemical vapor deposition system for high-throughput nanomaterial synthesis and process discovery

    SciTech Connect (OSTI)

    Oliver, C. Ryan; Westrick, William; Koehler, Jeremy; Brieland-Shoultz, Anna; Anagnostopoulos-Politis, Ilias; Cruz-Gonzalez, Tizoc [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States)] [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Hart, A. John, E-mail: ajhart@mit.edu [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

    2013-11-15T23:59:59.000Z

    Laboratory research and development on new materials, such as nanostructured thin films, often utilizes manual equipment such as tube furnaces due to its relatively low cost and ease of setup. However, these systems can be prone to inconsistent outcomes due to variations in standard operating procedures and limitations in performance such as heating and cooling rates restrict the parameter space that can be explored. Perhaps more importantly, maximization of research throughput and the successful and efficient translation of materials processing knowledge to production-scale systems, relies on the attainment of consistent outcomes. In response to this need, we present a semi-automated lab-scale chemical vapor deposition (CVD) furnace system, called “Robofurnace.” Robofurnace is an automated CVD system built around a standard tube furnace, which automates sample insertion and removal and uses motion of the furnace to achieve rapid heating and cooling. The system has a 10-sample magazine and motorized transfer arm, which isolates the samples from the lab atmosphere and enables highly repeatable placement of the sample within the tube. The system is designed to enable continuous operation of the CVD reactor, with asynchronous loading/unloading of samples. To demonstrate its performance, Robofurnace is used to develop a rapid CVD recipe for carbon nanotube (CNT) forest growth, achieving a 10-fold improvement in CNT forest mass density compared to a benchmark recipe using a manual tube furnace. In the long run, multiple systems like Robofurnace may be linked to share data among laboratories by methods such as Twitter. Our hope is Robofurnace and like automation will enable machine learning to optimize and discover relationships in complex material synthesis processes.

  15. Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods

    SciTech Connect (OSTI)

    Lewis, Amanda; Zhao, Hongbin; Hopkins, Scott

    2014-09-30T23:59:59.000Z

    This report summarizes the work completed under the U.S. Department of Energy Project Award No.: DE-FE0001181 titled “Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods.” The project started in October 1, 2009 and was finished September 30, 2014. Pall Corporation worked with Cornell University to sputter and test palladium-based ternary alloys onto silicon wafers to examine many alloys at once. With the specialized equipment at Georgia Institute of Technology that analyzed the wafers for adsorbed carbon and sulfur species six compositions were identified to have resistance to carbon and sulfur species. These compositions were deposited on Pall AccuSepź supports by Colorado School of Mines and then tested in simulated synthetic coal gas at the Pall Corporation. Two of the six alloys were chosen for further investigations based on their performance. Alloy reproducibility and long-term testing of PdAuAg and PdZrAu provided insight to the ability to manufacture these compositions for testing. PdAuAg is the most promising alloy found in this work based on the fabrication reproducibility and resistance to carbon and sulfur. Although PdZrAu had great initial resistance to carbon and sulfur species, the alloy composition has a very narrow range that hindered testing reproducibility.

  16. High-Throughput and Combinatorial Screening

    E-Print Network [OSTI]

    , for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL Hydride + H2 Complex Hydride Boride + Binary Hydride + H2 Metal Borohydride We can test six samples per vessel design complete ­ 15 sample hotplates, 3 gas detectors Achieve sample temperatures of 1200 K and H

  17. DOE Workshop HIGH THROUGHPUT/COMBINATORIAL SCREENING

    E-Print Network [OSTI]

    Properties Characterization · Optical/Electronic Materials · Vapor Phase Thin-Film Synthesis · Solution Phase Library Synthesis · HT Materials Characterization · HT Device Fabrication and Performance Evaluation #12/displays, materials for digital radiography, inorganic and organic OLEDs, TCOs Electronics Applications semiconductors

  18. Attendees list from the U.S. Department of Energy's High Throughput...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Attendees list from the U.S. Department of Energy's High Throughput Screening of Hydrogen Storage Materials Workshop on June 26, 2007 Attendees list from the U.S. Department of...

  19. LANL to certify automated influenza surveillance system

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    will design the automated high-throughput extraction and screening system for a prototype Global Bio Lab-a compact, modular laboratory that can reliably process thousands of...

  20. High throughput 3-D tissue cytometry

    E-Print Network [OSTI]

    Kwon, Hyuk-Sang, 1971-

    2007-01-01T23:59:59.000Z

    This thesis presents the ongoing technological development of high throughput 3-D tissue cytometry.and its applications in biomedicine. 3-D tissue cytometry has been developed in our laboratory based on two-photon microscopy ...

  1. High-throughput quantification of glycoprotein sialylation

    E-Print Network [OSTI]

    Markely, Lam Raga Anggara

    2011-01-01T23:59:59.000Z

    Sialic acid can improve qualities of therapeutic glycoproteins, such as circulatory half-life, biological activity, and solubility. In production of therapeutic glycoproteins, a high-throughput method (HTM) is required for ...

  2. High Throughput Materials Characterization John M. Gregoire

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Paper for Establishing a User Facility for Synchrotron-based High Throughput Materials Characterization John M. Gregoire 1 , Matthew J. Kramer 2 , Apurva Mehta 3 1 Joint Center for...

  3. High-Throughput/Combinatorial Techniques in Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D (presentation) High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D (presentation)...

  4. Potential of High-Throughput Experimentation with Ammonia Borane...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of High-Throughput Experimentation with Ammonia Borane Solid Hydrogen Storage Materials (presentation) Potential of High-Throughput Experimentation with Ammonia Borane Solid...

  5. CellVisualizer : exploring hierarchical, multi-dimensional data with applications to high-throughput microscopy

    E-Print Network [OSTI]

    Kang, InHan

    2006-01-01T23:59:59.000Z

    In this thesis, we present a system for visualizing hierarchical, multi-dimensional, memory-intensive datasets. Specifically, we designed an interactive system to visualize data collected by high-throughput microscopy and ...

  6. Chemistry & Biology Genome-Wide High-Throughput Mining

    E-Print Network [OSTI]

    Yin, Jun

    Chemistry & Biology Article Genome-Wide High-Throughput Mining of Natural-Product Biosynthetic Gene.01.006 SUMMARY We have developed a phage-display method for high-throughput mining of bacterial gene clus- ters

  7. HIGH-THROUGHPUT CELL AND PARTICLE CHARACTERIZATION USING ISO-DIELECTRIC

    E-Print Network [OSTI]

    Voldman, Joel

    HIGH-THROUGHPUT CELL AND PARTICLE CHARACTERIZATION USING ISO-DIELECTRIC SEPARATION Michael D. Vahey conductivity. Using a re- cently developed separation method - iso-dielectric separation (IDS) - we character for developing new screens. THEORY We recently developed a separa- tion method, called iso-dielectric sepa

  8. A microfluidic platform for high-throughput multiplexed protein quantitation

    E-Print Network [OSTI]

    Volpetti, Francesca; Maerkl, Sebastian

    2014-01-01T23:59:59.000Z

    We present a high-throughput microfluidic platform capable of quantitating up to 384 biomarkers in 4 distinct samples by immunoassay. The microfluidic device contains 384 unit cells, which can be individually programmed with pairs of capture and detection antibody. Samples are quantitated in each unit cell by four independent MITOMI detection areas, allowing four samples to be analyzed in parallel for a total of 1,536 assays per device. We show that the device can be pre-assembled and stored for weeks at elevated temperature and we performed proof-of-concept experiments simultaneously quantitating IL-6, IL-1\\b{eta}, TNF-{\\alpha}, PSA, and GFP. Finally, we show that the platform can be used to identify functional antibody combinations by screening 64 antibody combinations requiring up to 384 unique assays per device.

  9. Evaluation of the effects of various culture condition on Cr (VI) reduction by Shewanella oneidensis MR-1 in a novel high-throughput mini-bioreactor

    E-Print Network [OSTI]

    Tang, Yinjie J.; Laidlaw, David; Gani, Kishen; Keasling, Jay D.

    2006-01-01T23:59:59.000Z

    high-throughput mini-bioreactor Yinjie Tang †,1 , Davidexamined using a mini-bioreactor system that independentlyreduction. The mini-bioreactor system enabled the rapid

  10. Novel System for Recalcitrance Screening Will Reduce Biofuels Production Costs; The Spectrum of Clean Energy Innovation (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2010-06-01T23:59:59.000Z

    Fact sheet describes a high-throughput screening process, developed at NREL, that enables researchers to screen a large variety of biomass feedstocks for traits that indicate they would easily convert to fermentable sugars.

  11. High Throughput Operando Studies using Fourier Transform Infrared...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Throughput Operando Studies using Fourier Transform Infrared Imaging and Raman Spectroscopy. High Throughput Operando Studies using Fourier Transform Infrared Imaging and Raman...

  12. Interactive Visual Analysis of High Throughput Text Streams

    SciTech Connect (OSTI)

    Steed, Chad A [ORNL; Potok, Thomas E [ORNL; Patton, Robert M [ORNL; Goodall, John R [ORNL; Maness, Christopher S [ORNL; Senter, James K [ORNL

    2012-01-01T23:59:59.000Z

    The scale, velocity, and dynamic nature of large scale social media systems like Twitter demand a new set of visual analytics techniques that support near real-time situational awareness. Social media systems are credited with escalating social protest during recent large scale riots. Virtual communities form rapidly in these online systems, and they occasionally foster violence and unrest which is conveyed in the users language. Techniques for analyzing broad trends over these networks or reconstructing conversations within small groups have been demonstrated in recent years, but state-of- the-art tools are inadequate at supporting near real-time analysis of these high throughput streams of unstructured information. In this paper, we present an adaptive system to discover and interactively explore these virtual networks, as well as detect sentiment, highlight change, and discover spatio- temporal patterns.

  13. A High-Throughput Macromolecule Characterization System

    E-Print Network [OSTI]

    Kim, Jae Hyun

    2013-08-31T23:59:59.000Z

    stability of macromolecules in response to various environmental perturbations. Numerous proteins and macromolecular complexes have been analyzed by EPDs to summarize results from large data sets from multiple biophysical techniques. The current EPD method...

  14. A new screen scanning system based on clustering screen objects

    E-Print Network [OSTI]

    Robinson, Peter

    A new screen scanning system based on clustering screen objects Pradipta Biswas Research Student with a computer through one or two switches with the help of a scanning mechanism. In this paper we present a new scanning technique based on clustering screen objects and then compare it with two other scanning systems

  15. High Throughput Combinatorial Screening of Biometic Metal-Organic...

    Broader source: Energy.gov (indexed) [DOE]

    - 50 cm -1 ) red-shifts upon adsorption *Can be complex, depending on exact adsorption environment *Partial charge transfer weakens H-H bond, red-shift *Are such strong...

  16. NETL Studies High Throughput Membrane Screening | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Saleshttp://www.fnal.gov/directorate/nalcal/nalcal02_07_05_files/nalcal.gif Directorate1, Issue 23 NETL Scientist Wins 2011NETLNETL

  17. High Throughput Combinatorial Screening of Biometic Metal-Organic Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a r r t t m m e efor Military

  18. High Throughput/Combinatorial Screening of Hydrogen Storage Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a r r t t m m e efor

  19. High Throughput/Combinatorial Screening of Hydrogen Storage Materials: UOP

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a r r t t m m e eforApproaches |

  20. High-Throughput and Combinatorial Screening of Hydrogen Storage Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a rDepartment ofofa

  1. Adaptive Congestion Control in Broadband-ISDN: High Throughput with Sustained Quality of Service

    E-Print Network [OSTI]

    Pitsillides, Andreas

    ). The controller regulates QoS by manipulating the flow of controllable traffic into the network. Controllability. In this paper we use an adaptive feedback and feedforward control system to maximise throughput such that the QoAdaptive Congestion Control in Broadband-ISDN: High Throughput with Sustained Quality of Service

  2. New Tools for High Throughput Chemistry and Biology 

    E-Print Network [OSTI]

    Galveia, Luciano Paulo Rosa

    2011-01-01T23:59:59.000Z

    New strategies for the high-throughput determination of protease substrate specificity using a dual colour microarray based format with a small library of FRET-based peptides were developed. Integral to this process was ...

  3. High-Throughput Mass-Spectrometry Monitoring for Multisubstrate Enzymes

    E-Print Network [OSTI]

    Davis, Ben G.

    (EC 2.4.1.22), and the recently isolated Arabidopsis thaliana GT UGT72B1 (EC 2.4.1.-). The GAR (green a fast, high-throughput method for finding potential donors and acceptors from substrate libraries

  4. Screening systems adapt to changing conditions

    SciTech Connect (OSTI)

    Fiscor, S.

    2009-08-15T23:59:59.000Z

    Prep plants are installing larger screening systems and synthetic media is meeting those challenges. The largest manufacturer of synthetic screen media is Polydeck located in Spartanburg, South Carolina. The company's primary product lines include modular polyurethane and rubber screen panels and the frame systems to support the media. The modular approach overcomes a wear problem in one area of the deck common on Banana screens and facilitates maintenance. A rubber formation used in 1- x 2-pt screen panels called the Flexi design is softer and allows more vibration than standard urethane panels. The Maxi screen panel design combined with the PipeTop II frame makes the system highly versatile. 1 photo.

  5. High throughput liquid absorption preconcentrator sampling instrument

    DOE Patents [OSTI]

    Zaromb, Solomon (Hinsdale, IL); Bozen, Ralph M. (Hattiesburg, MS)

    1992-01-01T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis.

  6. High throughput liquid absorption preconcentrator sampling instrument

    DOE Patents [OSTI]

    Zaromb, S.; Bozen, R.M.

    1992-12-22T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis. 12 figs.

  7. Updating Interconnection Screens for PV System Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Abraham Ellis, Roger Hill Sandia National Laboratories Tom Key, Kristen Nicole, Jeff Smith Electric Power Research Institute Updating Interconnection Screens for PV System...

  8. IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 32, NO. 10, OCTOBER 2013 1791 DevStaR: High-Throughput Quantification

    E-Print Network [OSTI]

    Sontag, Eduardo

    of C. elegans embryonic viability in high-throughput (HTP) applications. A leading genetic model organism for the study of animal development and behavior, C. elegans is particularly amenable to HTP the algorithmic design of the DevStaR system and demonstrate its performance in scoring image data acquired in HTP

  9. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements RecentlyElectronicResources ResourcesRobust, High-Throughput Analysis of

  10. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements RecentlyElectronicResources ResourcesRobust, High-Throughput Analysis

  11. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 toAdvances WindRobust, High-Throughput

  12. A high throughput (>90%), large compensation range, single-prism femtosecond pulse compressor

    E-Print Network [OSTI]

    Kong, Lingjie

    2013-01-01T23:59:59.000Z

    We demonstrate a high throughput, large compensation range, single-prism femtosecond pulse compressor, using a single prism and two roof mirrors. The compressor has zero angular dispersion, zero spatial dispersion, zero pulse-front tilt, and unity magnification. The high efficiency is achieved by adopting two roof mirrors as the retroreflectors. We experimentally achieved ~ -14500 fs2 group delay dispersion (GDD) with 30 cm of prism tip-roof mirror prism separation, and ~90.7% system throughput with the current implementation. With better components, the throughput can be even higher.

  13. Development of Control Applications for High-Throughput Protein Crystallography Experiments

    SciTech Connect (OSTI)

    Gaponov, Yurii A.; Matsugaki, Naohiro; Honda, Nobuo; Sasajima, Kumiko; Igarashi, Noriyuki; Hiraki, Masahiko; Yamada, Yusuke; Wakatsuki, Soichi [Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba, Ibaraki (Japan)

    2007-01-19T23:59:59.000Z

    An integrated client-server control system (PCCS) with a unified relational database (PCDB) has been developed for high-throughput protein crystallography experiments on synchrotron beamlines. The major steps in protein crystallographic experiments (purification, crystallization, crystal harvesting, data collection, and data processing) are integrated into the software. All information necessary for performing protein crystallography experiments is stored in the PCDB database (except raw X-ray diffraction data, which is stored in the Network File Server). To allow all members of a protein crystallography group to participate in experiments, the system was developed as a multi-user system with secure network access based on TCP/IP secure UNIX sockets. Secure remote access to the system is possible from any operating system with X-terminal and SSH/X11 (Secure Shell with graphical user interface) support. Currently, the system covers the high-throughput X-ray data collection stages and is being commissioned at BL5A and NW12A (PF, PF-AR, KEK, Tsukuba, Japan)

  14. Updating Interconnection Screens for PV System Integration

    SciTech Connect (OSTI)

    Coddington, M.; Mather, B.; Kroposki, B.; Lynn, K.; Razon, A.; Ellis, A.; Hill, R.; Key, T.; Nicole, K.; Smith, J.

    2012-02-01T23:59:59.000Z

    This white paper evaluates the origins and usefulness of the capacity penetration screen, offer short-term solutions which could effectively allow fast-track interconnection to many PV system applications, and considers longer-term solutions for increasing PV deployment levels in a safe and reliable manner while reducing or eliminating the emphasis on the penetration screen. Short-term and longer-term alternatives approaches are offered as examples; however, specific modifications to screening procedures should be discussed with stakeholders and must ultimately be adopted by state and federal regulatory bodies.

  15. Generalized schemes for high throughput manipulation of the Desulfovibrio vulgaris Hildenborough genome

    SciTech Connect (OSTI)

    Chhabra, S.R.; Butland, G.; Elias, D.; Chandonia, J.-M.; Fok, V.; Juba, T.; Gorur, A.; Allen, S.; Leung, C.-M.; Keller, K.; Reveco, S.; Zane, G.; Semkiw, E.; Prathapam, R.; Gold, B.; Singer, M.; Ouellet, M.; Sazakal, E.; Jorgens, D.; Price, M.; Witkowska, E.; Beller, H.; Hazen, T.C.; Biggin, M.; Auer, M.; Wall, J.; Keasling, J.

    2011-07-15T23:59:59.000Z

    The ability to conduct advanced functional genomic studies of the thousands of sequenced bacteria has been hampered by the lack of available tools for making high- throughput chromosomal manipulations in a systematic manner that can be applied across diverse species. In this work, we highlight the use of synthetic biological tools to assemble custom suicide vectors with reusable and interchangeable DNA “parts” to facilitate chromosomal modification at designated loci. These constructs enable an array of downstream applications including gene replacement and creation of gene fusions with affinity purification or localization tags. We employed this approach to engineer chromosomal modifications in a bacterium that has previously proven difficult to manipulate genetically, Desulfovibrio vulgaris Hildenborough, to generate a library of over 700 strains. Furthermore, we demonstrate how these modifications can be used for examining metabolic pathways, protein-protein interactions, and protein localization. The ubiquity of suicide constructs in gene replacement throughout biology suggests that this approach can be applied to engineer a broad range of species for a diverse array of systems biological applications and is amenable to high-throughput implementation.

  16. Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

    E-Print Network [OSTI]

    Wu, Zhigang

    2009-01-01T23:59:59.000Z

    Soft inertial microfluidics for high throughput separation1 Introduction Microfluidics has gained significant advancesof mammalian cells using microfluidics 3,4 , there have been

  17. Smart Screening System (S3) In Taconite

    SciTech Connect (OSTI)

    Daryoush Allaei

    2006-09-08T23:59:59.000Z

    The conventional screening machines used in processing plants have had undesirable high noise and vibration levels. They also have had unsatisfactorily low screening efficiency, high energy consumption, high maintenance cost, low productivity, and poor worker safety. These conventional vibrating machines have been used in almost every processing plant. Most of the current material separation technology uses heavy and inefficient electric motors with an unbalanced rotating mass to generate the shaking. In addition to being excessively noisy, inefficient, and high-maintenance, these vibrating machines are often the bottleneck in the entire process. Furthermore, these motors, along with the vibrating machines and supporting structure, shake other machines and structures in the vicinity. The latter increases maintenance costs while reducing worker health and safety. The conventional vibrating fine screens at taconite processing plants have had the same problems as those listed above. This has resulted in lower screening efficiency, higher energy and maintenance cost, and lower productivity and workers safety concerns. The focus of this work is on the design of a high performance screening machine suitable for taconite processing plants. SmartScreens{trademark} technology uses miniaturized motors, based on smart materials, to generate the shaking. The underlying technologies are Energy Flow Control{trademark} and Vibration Control by Confinement{trademark}. These concepts are used to direct energy flow and confine energy efficiently and effectively to the screen function. The SmartScreens{trademark} technology addresses problems related to noise and vibration, screening efficiency, productivity, and maintenance cost and worker safety. Successful development of SmartScreens{trademark} technology will bring drastic changes to the screening and physical separation industry. The final designs for key components of the SmartScreens{trademark} have been developed. The key components include smart motor and associated electronics, resonators, and supporting structural elements. It is shown that the smart motors have an acceptable life and performance. Resonator (or motion amplifier) designs are selected based on the final system requirement and vibration characteristics. All the components for a fully functional prototype are fabricated and have been tested.

  18. High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation

    E-Print Network [OSTI]

    Zandstra, Peter W.

    High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation a microfluidic approach for high-throughput generation of 3D microenvironments with different elasticity for studies of cell fate. The generation of agarose microgels with different elastic moduli was achieved by (i

  19. Assessing the Thermoelectric Properties of Sintered Compounds via High-Throughput Ab-Initio Calculations

    E-Print Network [OSTI]

    Curtarolo, Stefano

    Assessing the Thermoelectric Properties of Sintered Compounds via High-Throughput Ab Database have been considered as nanograined, sintered-powder thermoelectrics with the high-throughput ab the electronic band gap and the carrier effective mass, and that the probability of having large thermoelectric

  20. High throughput energy efficient multi-FFT architecture on FPGAs (Draft)

    E-Print Network [OSTI]

    Prasanna, Viktor K.

    computing, High throughput FFT, Energy efficient design I. INTRODUCTION As FPGAs are programmed specifically in spread spec- trum receiver [4]. In the design of high throughput FFT architectures, energy-efficient design techniques can be used to maximize performance under power dissipation constraints. The power

  1. Parallel Interleaver Architecture with New Scheduling Scheme for High Throughput Configurable Turbo Decoder

    E-Print Network [OSTI]

    Mellor-Crummey, John

    Parallel Interleaver Architecture with New Scheduling Scheme for High Throughput Configurable Turbo}@rice.edu, yuanbinguo@huawei.com Abstract--Parallel architecture is required for high throughput turbo decoder to meet also shows great flexibility and scalability compared to prior work. Index Terms--VLSI, turbo decoder

  2. Heterogeneous High Throughput Scientific Computing with APM X-Gene and Intel Xeon Phi

    E-Print Network [OSTI]

    David Abdurachmanov; Brian Bockelman; Peter Elmer; Giulio Eulisse; Robert Knight; Shahzad Muzaffar

    2014-10-10T23:59:59.000Z

    Electrical power requirements will be a constraint on the future growth of Distributed High Throughput Computing (DHTC) as used by High Energy Physics. Performance-per-watt is a critical metric for the evaluation of computer architectures for cost- efficient computing. Additionally, future performance growth will come from heterogeneous, many-core, and high computing density platforms with specialized processors. In this paper, we examine the Intel Xeon Phi Many Integrated Cores (MIC) co-processor and Applied Micro X-Gene ARMv8 64-bit low-power server system-on-a-chip (SoC) solutions for scientific computing applications. We report our experience on software porting, performance and energy efficiency and evaluate the potential for use of such technologies in the context of distributed computing systems such as the Worldwide LHC Computing Grid (WLCG).

  3. automated high throughput: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of such a more database-centric approach. Roehm, Uwe 2009-01-01 31 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites...

  4. Towards Chip Scale Liquid Chromatography and High Throughput Immunosensing

    SciTech Connect (OSTI)

    Ni, J.

    2000-09-21T23:59:59.000Z

    This work describes several research projects aimed towards developing new instruments and novel methods for high throughput chemical and biological analysis. Approaches are taken in two directions. The first direction takes advantage of well-established semiconductor fabrication techniques and applies them to miniaturize instruments that are workhorses in analytical laboratories. Specifically, the first part of this work focused on the development of micropumps and microvalves for controlled fluid delivery. The mechanism of these micropumps and microvalves relies on the electrochemically-induced surface tension change at a mercury/electrolyte interface. A miniaturized flow injection analysis device was integrated and flow injection analyses were demonstrated. In the second part of this work, microfluidic chips were also designed, fabricated, and tested. Separations of two fluorescent dyes were demonstrated in microfabricated channels, based on an open-tubular liquid chromatography (OT LC) or an electrochemically-modulated liquid chromatography (EMLC) format. A reduction in instrument size can potentially increase analysis speed, and allow exceedingly small amounts of sample to be analyzed under diverse separation conditions. The second direction explores the surface enhanced Raman spectroscopy (SERS) as a signal transduction method for immunoassay analysis. It takes advantage of the improved detection sensitivity as a result of surface enhancement on colloidal gold, the narrow width of Raman band, and the stability of Raman scattering signals to distinguish several different species simultaneously without exploiting spatially-separated addresses on a biochip. By labeling gold nanoparticles with different Raman reporters in conjunction with different detection antibodies, a simultaneous detection of a dual-analyte immunoassay was demonstrated. Using this scheme for quantitative analysis was also studied and preliminary dose-response curves from an immunoassay of a mo del antigen were obtained. Simultaneous detection of several analytes at the same address can potentially increase the analysis speed, and can further expand the analysis capability of a microarray chip.

  5. Metal Organic Framework Research: High Throughput Discovery of Robust Metal Organic Framework for CO2 Capture

    SciTech Connect (OSTI)

    None

    2010-08-01T23:59:59.000Z

    IMPACCT Project: LBNL is developing a method for identifying the best metal organic frameworks for use in capturing CO2 from the flue gas of coal-fired power plants. Metal organic frameworks are porous, crystalline compounds that, based on their chemical structure, vary considerably in terms of their capacity to grab hold of passing CO2 molecules and their ability to withstand the harsh conditions found in the gas exhaust of coal-fired power plants. Owing primarily to their high tunability, metal organic frameworks can have an incredibly wide range of different chemical and physical properties, so identifying the best to use for CO2 capture and storage can be a difficult task. LBNL uses high-throughput instrumentation to analyze nearly 100 materials at a time, screening them for the characteristics that optimize their ability to selectively adsorb CO2 from coal exhaust. Their work will identify the most promising frameworks and accelerate their large-scale commercial development to benefit further research into reducing the cost of CO2 capture and storage.

  6. Bonus Organisms in High-Throughput Eukaryotic Whole-Genome Shorgun Assembly

    SciTech Connect (OSTI)

    Pangilinan, Jasmyn; Shapiro, Harris; Tu, Hank; Platt, Darren

    2006-02-06T23:59:59.000Z

    The DOE Joint Genome Institute has sequenced over 50 eukaryotic genomes, ranging in size from 15 MB to 1.6 GB, over a wide range of organism types. In the course of doing so, it has become clear that a substantial fraction of these data sets contains bonus organisms, usually prokaryotes, in addition to the desired genome. While some of these additional organisms are extraneous contamination, they are sometimes symbionts, and so can be of biological interest. Therefore, it is desirable to assemble the bonus organisms along with the main genome. This transforms the problem into one of metagenomic assembly, which is considerably more challenging than traditional whole-genome shotgun (WGS) assembly. The different organisms will usually be present at different sequence depths, which is difficult to handle in most WGS assemblers. In addition, with multiple distinct genomes present, chimerism can produce cross-organism combinations. Finally, there is no guarantee that only a single bonus organism will be present. For example, one JGI project contained at least two different prokaryotic contaminants, plus a 145 KB plasmid of unknown origin. We have developed techniques to routinely identify and handle such bonus organisms in a high-throughput sequencing environment. Approaches include screening and partitioning the unassembled data, and iterative subassemblies. These methods are applicable not only to bonus organisms, but also to desired components such as organelles. These procedures have the additional benefit of identifying, and allowing for the removal of, cloning artifacts such as E.coli and spurious vector inclusions.

  7. Microelectroporation device for genomic screening

    DOE Patents [OSTI]

    Perroud, Thomas D.; Renzi, Ronald F.; Negrete, Oscar; Claudnic, Mark R.

    2014-09-09T23:59:59.000Z

    We have developed an microelectroporation device that combines microarrays of oligonucleotides, microfluidic channels, and electroporation for cell transfection and high-throughput screening applications (e.g. RNA interference screens). Microarrays allow the deposition of thousands of different oligonucleotides in microscopic spots. Microfluidic channels and microwells enable efficient loading of cells into the device and prevent cross-contamination between different oligonucleotides spots. Electroporation allows optimal transfection of nucleic acids into cells (especially hard-to-transfect cells such as primary cells) by minimizing cell death while maximizing transfection efficiency. This invention has the advantage of a higher throughput and lower cost, while preventing cross-contamination compared to conventional screening technologies. Moreover, this device does not require bulky robotic liquid handling equipment and is inherently safer given that it is a closed system.

  8. High-Throughput, High-Precision Hot Testing Tool for High-Brightness...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Throughput, High-Precision Hot Testing Tool for High-Brightness Light-Emitting Diode Testing High-Throughput, High-Precision Hot Testing Tool for High-Brightness Light-Emitting...

  9. Cell bioprinting as a potential high-throughput method for fabricating cell-based biosensors (CBBs)

    E-Print Network [OSTI]

    Xu, F.

    Cell-based biosensors (CBBs) are becoming an important tool for biosecurity applications and rapid diagnostics. For current CBBs technology, cell immobilization and high throughput fabrication are the main challenges. To ...

  10. Engineering a single cell microarray platform for high throughput DNA damage and repair analysis

    E-Print Network [OSTI]

    Weingeist, David McGregor

    2012-01-01T23:59:59.000Z

    DNA damage contributes to cancer, aging, and heritable diseases. Ironically, DNA damaging agents are also commonly used in current cancer treatment. We therefore need robust, high throughput, and inexpensive tools for ...

  11. Molecular display of synthetic oligonucleotide libraries and their analysis with high throughput DNA sequencing

    E-Print Network [OSTI]

    Larman, Harry Benjamin

    2012-01-01T23:59:59.000Z

    High throughput methods in molecular biology have changed the landscape of biomedical research. In particular, advances in massively parallel DNA sequencing and synthesis technologies are defining our genomes and the ...

  12. An instrument for high-throughput measurements of fiber mechanical properties

    E-Print Network [OSTI]

    Kristofek, Grant William, 1980-

    2005-01-01T23:59:59.000Z

    In this thesis, an instrument is designed and constructed for the purpose of measuring the mechanical properties of single fibers. The instrument is intended to provide high throughput measurement of single fiber geometric ...

  13. A microfluidic device for high throughput bacterial biofilm studies Jeongyun Kim,a

    E-Print Network [OSTI]

    Wood, Thomas K.

    A microfluidic device for high throughput bacterial biofilm studies Jeongyun Kim,a Manjunath Hegde of biofilm community formation. Here, we describe the development of a PDMS-based two-layer microfluidic flow

  14. Screening method for wind energy conversion systems

    SciTech Connect (OSTI)

    McConnell, R.D.

    1980-03-01T23:59:59.000Z

    A screening method is presented for evaluating wind energy conversion systems (WECS) logically and consistently. It is a set of procedures supported by a data base for large conventional WECS. The procedures are flexible enough to accommodate concepts lacking cost and engineering detail, as is the case with many innovative wind energy conversion systems (IWECS). The method uses both value indicators and simplified cost estimating procedures. Value indicators are selected ratios of engineering parameters involving energy, mass, area, and power. Cost mass ratios and cost estimating relationships were determined from the conventional WECS data base to estimate or verify installation cost estimates for IWECS. These value indicators and cost estimating procedures are shown for conventional WECS. An application of the method to a tracked-vehicle airfoil concept is presented.

  15. Miniaturized Analytical Platforms From Nanoparticle Components: Studies in the Construction, Characterization, and High-Throughput Usage of These Novel Architectures

    SciTech Connect (OSTI)

    Andrew David Pris

    2003-08-05T23:59:59.000Z

    The scientific community has recently experienced an overall effort to reduce the physical size of many experimental components to the nanometer size range. This size is unique as the characteristics of this regime involve aspects of pure physics, biology, and chemistry. One extensively studied example of a nanometer sized experimental component, which acts as a junction between these three principle scientific theologies, is deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). These biopolymers not only contain the biological genetic guide to code for the production of life-sustaining materials, but are also being probed by physicists as a means to create electrical circuits and furthermore as controllable architectural and sensor motifs in the chemical disciplines. Possibly the most common nano-sized component between these sciences are nanoparticles composed of a variety of materials. The cross discipline employment of nanoparticles is evident from the vast amount of literature that has been produced from each of the individual communities within the last decade. Along these cross-discipline lines, this dissertation examines the use of several different types of nanoparticles with a wide array of surface chemistries to understand their adsorption properties and to construct unique miniaturized analytical and immunoassay platforms. This introduction will act as a literature review to provide key information regarding the synthesis and surface chemistries of several types of nanoparticles. This material will set the stage for a discussion of assembling ordered arrays of nanoparticles into functional platforms, architectures, and sensors. The introduction will also include a short explanation of the atomic force microscope that is used throughout the thesis to characterize the nanoparticle-based structures. Following the Introduction, four research chapters are presented as separate manuscripts. Chapter 1 examines the self-assembly of polymeric nanoparticles exhibiting a variety of surface chemistries and attempts to deconvolute general adsorption rules for their assembly on various substrates. Chapter 2 extends the usage of self-assembly of polymeric nanoparticles through a layer-by-layer deposition concept and photolithography methodologies to create analytical platforms with a vertical height controlled within the nanometer regime. This platform is then furthered in Chapter 3 by employing this integrated concept as a bio-recognition platform, with the extension of the method to a high-throughput screening system explored. Chapter 4 exploits two different types of nanoparticles, silica and gold, as multiplexed, self-assembled immunoassay sensors. This final research chapter is followed by a general summation and future prospectus section that concludes the dissertation.

  16. A search model for topological insulators with high-throughput robustness descriptors

    SciTech Connect (OSTI)

    Yang, Kesong; Setyawan, Wahyu; Wang, Shidong; Nardelli, Marco B.; Curtarolo, Stephano

    2012-05-13T23:59:59.000Z

    Topological insulators (TI) are becoming one of the most studied classes of novel materials because of their great potential for applications ranging from spintronics to quantum computers. To fully integrate TI materials in electronic devices, high-quality epitaxial single-crystalline phases with sufficiently large bulk bandgaps are necessary. Current efforts have relied mostly on costly and time-consuming trial-and-error procedures. Here we show that by defining a reliable and accessible descriptor {cflx X}TI, which represents the topological robustness or feasibility of the candidate, and by searching the quantum materials repository aflowlib.org, we have automatically discovered 28 TIs (some of them already known) in five different symmetry families. These include peculiar ternary halides, Cs{l_brace}Sn,Pb,Ge{r_brace}{l_brace}Cl,Br,I{r_brace}{sub 3}, which could have been hardly anticipated without high-throughput means. Our search model, by relying on the significance of repositories in materials development, opens new avenues for the discovery of more TIs in different and unexplored classes of systems.

  17. A microreactor array for spatially resolved measurement of catalytic activity for high-throughput catalysis science

    SciTech Connect (OSTI)

    Kondratyuk, Petro; Gumuslu, Gamze; Shukla, Shantanu; Miller, James B.; Morreale, Bryan D.; Gellman, Andrew J.

    2013-04-01T23:59:59.000Z

    We describe a 100 channel microreactor array capable of spatially resolved measurement of catalytic activity across the surface of a flat substrate. When used in conjunction with a composition spread alloy film (CSAF, e.g. Pd{sub x}Cu{sub y}Au{sub 1-x-y}) across which component concentrations vary smoothly, such measurements permit high-throughput analysis of catalytic activity and selectivity as a function of catalyst composition. In the reported implementation, the system achieves spatial resolution of 1 mm{sup 2} over a 10Ś10 mm{sup 2} area. During operation, the reactant gases are delivered at constant flow rate to 100 points of differing composition on the CSAF surface by means of a 100-channel microfluidic device. After coming into contact with the CSAF catalyst surface, the product gas mixture from each of the 100 points is withdrawn separately through a set of 100 isolated channels for analysis using a mass spectrometer. We demonstrate the operation of the device on a Pd{sub x}Cu{sub y}Au{sub 1-x-y} CSAF catalyzing the H{sub 2}-D{sub 2} exchange reaction at 333 K. In essentially a single experiment, we measured the catalytic activity over a broad swathe of concentrations from the ternary composition space of the Pd{sub x}Cu{sub y}Au{sub 1-x-y} alloy.

  18. Synthesis and characterization of four new metal 5-phosphonoisophthalates discovered by high-throughput experimentation

    SciTech Connect (OSTI)

    Bauer, Sebastian [Institute of Inorganic Chemistry, Christian-Albrechts-University, Otto-Hahn-Platz 6/7, D 24098 Kiel (Germany); Stock, Norbert [Institute of Inorganic Chemistry, Christian-Albrechts-University, Otto-Hahn-Platz 6/7, D 24098 Kiel (Germany)], E-mail: stock@ac.uni-kiel.de

    2007-11-15T23:59:59.000Z

    A new ligand, 5-diethylphosphonoisophthalic acid ((HOOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}(C{sub 2}H{sub 5}){sub 2}, H{sub 2}Et{sub 2}L), for the hydrothermal synthesis of inorganic-organic hybrid compounds was prepared and characterized by NMR-spectroscopy. Its in situ hydrolysis leads to the corresponding 5-phosphonoisophthalic acid ((HOOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}H{sub 2}, H{sub 4}L). Applying high-throughput methods, different di- and trivalent metal salts for the synthesis of crystalline metal phosphonates based on H{sub 2}Et{sub 2}L have been screened. From the resulting discovery library, single-crystals of four new compounds, [Sm{sub 2}(H{sub 2}O){sub 4}(H(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}){sub 2}].2H{sub 2}O (1), [Cu{sub 3}(H{sub 2}O)(H(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}){sub 2}].2H{sub 2}O (2), Ca{sub 2}(H{sub 2}O)[H(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}H]{sub 2} (3), and Ba{sub 2}(H{sub 2}O){sub 3}(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3} (4), have been isolated. The single-crystal structure determination of the title compounds shows H{sub 4}L to be a versatile ligand, exhibiting different types of coordination modes between the functional groups and the metal ions. A comparison of the structural features of the title compounds shows a varying degree of M-O-M connectivities. Thus, isolated metal-oxygen clusters (compounds 1 and 2), infinite M-O-M chains (compound 3), and infinite M-O-M layers (compound 4) are observed. The title compounds 1, 2, and 3 were further characterized by IR-spectroscopy, TG-, EDX-, and elemental chemical analysis. - Graphical abstract: Applying high-throughput methods, the new ligand 5-diethylphosphonoisophtalic acid, (HOOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}(C{sub 2}H{sub 5}){sub 2} (H{sub 2}Et{sub 2}L), was reacted with several di- and trivalent metal salts under hydrothermal conditions. Single-crystals of four new inorganic-organic hybrid compounds were isolated from the discovery library. The single-crystal structure analysis shows a varying M-O-M connectivity.

  19. Postdoctoral opportunities are available immediately in a project investigating molecular mechanisms of neurogenic hypertension. We take a systems biology

    E-Print Network [OSTI]

    Pillow, Jonathan

    mechanisms of neurogenic hypertension. We take a systems biology approach involving high-throughput data

  20. High-throughput scanning confocal microscope for single molecule Chandran R. Sabanayagam, John S. Eid, and Amit Mellera)

    E-Print Network [OSTI]

    Meller, Amit

    High-throughput scanning confocal microscope for single molecule analysis Chandran R. Sabanayagam and probing of single molecules, and an automatic focusing feature that enables the unattended scanning

  1. A high-throughput three-dimensional cell migration assay for toxicity screening

    E-Print Network [OSTI]

    Diseases, University of Texas Health Science Center, Houston, TX 77030 USA. There is a growing demand,19­21 . These nanoparticles are nontoxic and do not induce an inflammatory cytokine (IL-6, IL-8) response by cells22 they interact and aggregate with each other to form larger 3D cultures. This method has been shown to induce

  2. Integrated microfluidic device for single-cell high throughput screening in dynamic gene expression analysis

    E-Print Network [OSTI]

    Hui, Lawrence Kwan Yeung

    2008-01-01T23:59:59.000Z

    iv v vii ix x xii 3.3.1 Gradient Generation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

  3. High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors

    E-Print Network [OSTI]

    Davenport, Jason; Blach, Maurie; Galam, Lakshmi; Girgis, Antwan; Hall, Jessica; Blagg, Brian S. J.; Matts, Robert L.

    2014-03-03T23:59:59.000Z

    Hsp90 has become the target of intensive investigation, as inhibition of its function has the ability to simultaneously incapacitate proteins that function in pathways that represent the six hallmarks of cancer. While a ...

  4. Discovery and High-Throughput Screening of Heteroleptic Iridium Complexes for Photoinduced Hydrogen Production

    E-Print Network [OSTI]

    Bernhard, Stefan

    researchers. Simple solar devices focus or collect sunlight, harnessing radiation in order to heat dwellings December 3, 2004; E-mail: sbernhar@princeton.edu Abstract: The catalytic process of photoinduced hydrogen of the hydrogen evolution process and facilitated mechanistic studies. All six compounds investigated produced

  5. Screening for high-performance piezoelectrics using high-throughput density functional theory

    E-Print Network [OSTI]

    Armiento, Rickard R.

    We present a large-scale density functional theory (DFT) investigation of the ABO3 chemical space in the perovskite crystal structure, with the aim of identifying those that are relevant for forming piezoelectric materials. ...

  6. A high-throughput in vivo micronucleus assay for genome instability screening in mice

    E-Print Network [OSTI]

    Balmus, Gabriel; Karp, Natasha A; Ng, Bee Ling; Jackson, Stephen P; Adams, David J; McIntyre, Rebecca E

    2014-12-31T23:59:59.000Z

    .jackson@gurdon.cam.ac.uk; Ng BL – bln@sanger.ac.uk; Adams DJ – da1@sanger.ac.uk; McIntyre R – rm5@sanger.ac.uk; Primary articles: 20 McIntyre, R.E. et al. Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome. PLoS Genet 8, e... into the mouse phenotyping pipeline, we have identified radiation-sensitive mutants, which exhibit increased levels of micronucleated-RET after irradiation but not before. Within this manuscript, 150 we provide additional details on data analysis...

  7. High throughput screen for cells with high extracellular metabolite consumption--secretion rates using microfluidic droplets

    E-Print Network [OSTI]

    Wang, Benjamin L. (Benjamin Lu chen)

    2009-01-01T23:59:59.000Z

    Metabolic engineering has contributed significantly to the improvement of strains for the industrial production of various compounds. Traditionally, enzymatic steps closely associated with the product-forming pathway have ...

  8. A high-throughput, near-saturating screen for type III effector genes from Pseudomonas syringae

    E-Print Network [OSTI]

    Dangl, Jeff

    criteria defined 29 type III proteins from P. syringae pv. tomato, and 19 from P. syringae pv. phaseolicola [disease resistance (R) pro- teins], a battery of host responses is triggered, including localized

  9. First principles high throughput screening of oxynitrides for water-splitting photocatalysts

    E-Print Network [OSTI]

    Ceder, Gerbrand

    and eleven quaternary oxynitrides. Broader context Water-splitting photocatalysis directly converts the solar and Honda,1,2 the photocatalysis of water splitting has become an active research area and a promising way

  10. High-Throughput Screening Platform for Engineered Nanoparticle-Mediated Genotoxicity Using CometChip Technology

    E-Print Network [OSTI]

    Watson, Christa

    The likelihood of intentional and unintentional engineered nanoparticle (ENP) exposure has dramatically increased due to the use of nanoenabled products. Indeed, ENPs have been incorporated in many useful products and have ...

  11. High-Throughput Computational Screening of thermal conductivity, Debye temperature and Gruneisen parameter

    E-Print Network [OSTI]

    Curtarolo, Stefano

    , such us the development of new thermoelectric materials1,2 , heat sink materials for ther- mal management and Materials Science, Duke University, Durham, North Carolina 27708, USA 2 Department of Materials Science Department of Physics and Department of Chemistry, University of North Texas, Denton TX 4 Materials Science

  12. Improved Algae-based Biorefining and High-throughput Screening of Algal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogenIT |HotImpact ofVisiting20143101 101

  13. Agenda from the U.S. Department of Energy's High Throughput Screening of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The Future of1Albuquerque, NM - Building America TopAgenda - DOE TribalHydrogen

  14. An apparatus for high throughput muscle cell experimentation

    E-Print Network [OSTI]

    Garcia-Webb, Michael G. (Michael Gregory)

    2006-01-01T23:59:59.000Z

    The cardiac ventricular muscle cell (myocyte) is a key experimental system for exploring the mechanical properties of the diseased and healthy heart. The myocyte experimental model provides a higher level of physiological ...

  15. High-throughput methods for characterizing the immune repertoire

    E-Print Network [OSTI]

    Laserson, Uri

    2013-01-01T23:59:59.000Z

    The adaptive immune system is one of the primary mediators in almost every major human disease, including infections, cancer, autoimmunity, and inflammation-based disorders. It fundamentally functions as a molecular ...

  16. High-throughput imaging of heterogeneous cell organelles with an X-ray laser

    SciTech Connect (OSTI)

    Hantke, Max, F.

    2014-11-17T23:59:59.000Z

    Preprocessed detector images that were used for the paper "High-throughput imaging of heterogeneous cell organelles with an X-ray laser". The CXI file contains the entire recorded data - including both hits and blanks. It also includes down-sampled images and LCLS machine parameters. Additionally, the Cheetah configuration file is attached that was used to create the pre-processed data.

  17. High-throughput imaging of heterogeneous cell organelles with an X-ray laser

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Hantke, Max, F.

    Preprocessed detector images that were used for the paper "High-throughput imaging of heterogeneous cell organelles with an X-ray laser". The CXI file contains the entire recorded data - including both hits and blanks. It also includes down-sampled images and LCLS machine parameters. Additionally, the Cheetah configuration file is attached that was used to create the pre-processed data.

  18. Development and operation of a high-throughput accurate-wavelength lens-based spectrometera)

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bell, Ronald E.

    2014-11-01T23:59:59.000Z

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy more »wavelength calibration.« less

  19. Treatability studies on different refinery wastewater samples using high-throughput microbial electrolysis cells (MECs)

    E-Print Network [OSTI]

    Treatability studies on different refinery wastewater samples using high-throughput microbial, University Park, PA 16802, USA h i g h l i g h t s Refinery wastewaters were tested as fuels in MECs effective for treatment or pre-treatment of some refinery wastewaters. The best way to start up MECs

  20. A High-Throughput Method to Examine Protein-Nucleotide Interactions Identifies Targets of the Bacterial

    E-Print Network [OSTI]

    A High-Throughput Method to Examine Protein- Nucleotide Interactions Identifies Targets can easily be applied to examine multiple protein-protein, protein-nucleotide and nucleotide-nucleotide Protein-Nucleotide Interactions Identifies Targets of the Bacterial Transcriptional Regulatory Protein Fur

  1. High-Throughput Contention-Free Concurrent Interleaver Architecture for Multi-Standard Turbo Decoder

    E-Print Network [OSTI]

    Mellor-Crummey, John

    High-Throughput Contention-Free Concurrent Interleaver Architecture for Multi-Standard Turbo paral- lel turbo decoder architectures have been developed. However, the interleaver has become a major that can efficiently solve the memory conflict problem for parallel turbo decoders with very high

  2. Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome

    E-Print Network [OSTI]

    Bourne, Philip E.

    Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome Annotation software on a high performance computing platform such as the grid. The Encyclopedia of Life (EOL) project application to drive grid software development. It is a flagship application for the TeraGrid project [3

  3. Oblique-incidence reflectivity difference microscope for label-free high-throughput detection of biochemical

    E-Print Network [OSTI]

    Zhu, Xiangdong

    Oblique-incidence reflectivity difference microscope for label-free high-throughput detection (OI-RD) microscope, a form of polarization-modulated imaging ellipsometer, for label on the polarizer­ compensator­sample­analyzer scheme and under the off-null condition, a polarization-modulated OI

  4. METHODS AND APPLICATIONS High-throughput instant quantification of

    E-Print Network [OSTI]

    Ihee, Hyotcherl

    based on photoactive yellow protein turn off/on label Youngmin Kim,1,2 Prabhakar Ganesan,1 on the Photoactive yellow protein turn Off/On Label (POOL) system that can instantly quan- tify the concentration Gel Electrophoresis; POOL, PYP turn Off/On Label; PYP, Photoactive Yellow Protein; SUMO, Small

  5. Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

    SciTech Connect (OSTI)

    Wu, Zhigang; Willing, Ben; Bjerketorp, Joakim; Jansson, Janet K.; Hjort, Klas

    2009-01-05T23:59:59.000Z

    We developed a new approach to separate bacteria from human blood cells based on soft inertial force induced migration with flow defined curved and focused sample flow inside a microfluidic device. This approach relies on a combination of an asymmetrical sheath flow and proper channel geometry to generate a soft inertial force on the sample fluid in the curved and focused sample flow segment to deflect larger particles away while the smaller ones are kept on or near the original flow streamline. The curved and focused sample flow and inertial effect were visualized and verified using a fluorescent dye primed in the device. First the particle behavior was studied in detail using 9.9 and 1.0 {micro}m particles with a polymer-based prototype. The prototype device is compact with an active size of 3 mm{sup 2}. The soft inertial effect and deflection distance were proportional to the fluid Reynolds number (Re) and particle Reynolds number (Re{sub p}), respectively. We successfully demonstrated separation of bacteria (Escherichia coli) from human red blood cells at high cell concentrations (above 10{sup 8}/mL), using a sample flow rate of up to 18 {micro}L/min. This resulted in at least a 300-fold enrichment of bacteria at a wide range of flow rates with a controlled flow spreading. The separated cells were proven to be viable. Proteins from fractions before and after cell separation were analyzed by gel electrophoresis and staining to verify the removal of red blood cell proteins from the bacterial cell fraction. This novel microfluidic process is robust, reproducible, simple to perform, and has a high throughput compared to other cell sorting systems. Microfluidic systems based on these principles could easily be manufactured for clinical laboratory and biomedical applications.

  6. http://jbx.sagepub.com Journal of Biomolecular Screening

    E-Print Network [OSTI]

    Chang, Shih-Fu

    /1/29 SAGE Journals Online and HighWire Press platforms): (this article cites 25 articles hosted on the of high-throughput screening (HTS) procedures coupled with auto- mated microscopy to generate large

  7. High-throughput liquid-absorption preconcentrator sampling methods

    DOE Patents [OSTI]

    Zaromb, Solomon (95706 William Dr., Hinsdale, IL 60521)

    1994-01-01T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis.

  8. High-throughput liquid-absorption preconcentrator sampling methods

    DOE Patents [OSTI]

    Zaromb, S.

    1994-07-12T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis. 12 figs.

  9. Screening

    Broader source: Energy.gov [DOE]

    Screening is typically performed by an outside party or an independent renewable energy expert or team. It is a review of the possible technology options that identifies dead-ends and further...

  10. Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

    SciTech Connect (OSTI)

    Hura, Greg L.; Menon, Angeli L.; Hammel, Michal; Rambo, Robert P.; Poole II, Farris L.; Tsutakawa, Susan E.; Jenney Jr, Francis E.; Classen, Scott; Frankel, Kenneth A.; Hopkins, Robert C.; Yang, Sungjae; Scott, Joseph W.; Dillard, Bret D.; Adams, Michael W. W.; Tainer, John A.

    2009-07-20T23:59:59.000Z

    We present an efficient pipeline enabling high-throughput analysis of protein structure in solution with small angle X-ray scattering (SAXS). Our SAXS pipeline combines automated sample handling of microliter volumes, temperature and anaerobic control, rapid data collection and data analysis, and couples structural analysis with automated archiving. We subjected 50 representative proteins, mostly from Pyrococcus furiosus, to this pipeline and found that 30 were multimeric structures in solution. SAXS analysis allowed us to distinguish aggregated and unfolded proteins, define global structural parameters and oligomeric states for most samples, identify shapes and similar structures for 25 unknown structures, and determine envelopes for 41 proteins. We believe that high-throughput SAXS is an enabling technology that may change the way that structural genomics research is done.

  11. New Composite Membranes for High Throughput Solid-Liquid Separations at the Savannah River Site

    SciTech Connect (OSTI)

    Bhave, Ramesh R [ORNL

    2012-01-01T23:59:59.000Z

    New Composite Membranes for High Throughput Solid-Liquid Separations at the Savannah River Site R. Bhave (Oak Ridge National Laboratory. Oak Ridge, TN) and M. R. Poirier* (Savannah River National Laboratory, Aiken SC) Solid-liquid separation is the limiting step for many waste treatment processes at the Savannah River Site. SRNL researchers have identified the rotary microfilter as a technology to improve the rate of solid-liquid separation processes. SRNL is currently developing the rotary microfilter for radioactive service and plans to deploy the technology as part of the small column ion exchange process. The rotary microfilter can utilize any filter media that is available as a flat sheet. The current baseline membrane is a 0.5 micron (nominal) porous metal filter (Pall PMM050). Previous testing with tubular filters showed that filters composed of a ceramic membrane on top of a stainless steel support produce higher flux than filters composed only of porous metal. The authors are working to develop flat sheet filter media composed of a ceramic membrane and/or ceramic-metal composite on top of a porous stainless steel support that can be used with the rotary microfilter to substantially increase filter flux resulting in a more compact, energy efficient and cost-effective high level radioactive waste treatment system. Composite membranes with precisely controlled pore size distribution were fabricated on porous metal supports. High quality uniform porous metal (316SS) supports were fabricated to achieve high water permeability. Separative layers of several different materials such as ultrafine metal particles and ceramic oxides were used to fabricate composite membranes. The fabrication process involved several high temperature heat treatments followed by characterization of gas and liquid permeability measurements and membrane integrity analysis. The fabricated composite membrane samples were evaluated in a static test cell manufactured by SpinTek. The composite membranes were evaluated on several feed slurries: 1 wt. % strontium carbonate in deionized water, 1 wt. % monosodium titanate in simulated salt solution, and 1 wt. % simulated sludge in simulated salt solution and deionized water. Flux as a function of feed flow rate and transmembrane pressure was measured for each of the above described feed slurries. The authors will discuss the new membrane development efforts, waste slurry filtration performance evaluations and scale-up considerations.

  12. Advances in high-throughput speed, low-latency communication for embedded instrumentation ( 7th Annual SFAF Meeting, 2012)

    ScienceCinema (OSTI)

    Jordan, Scott [Physik Instrumente

    2013-02-11T23:59:59.000Z

    Scott Jordan on "Advances in high-throughput speed, low-latency communication for embedded instrumentation" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  13. High Throughput Plasmid Sequencing with Illumina and CLC Bio (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema (OSTI)

    Athavale, Ajay [Monsanto

    2013-01-25T23:59:59.000Z

    Ajay Athavale (Monsanto) presents "High Throughput Plasmid Sequencing with Illumina and CLC Bio" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  14. High Throughput Synthesis of Uniform Biocompatible Polymer Beads with High Quantum Dot Loading Using Microfluidic Jet-Mode Breakup

    E-Print Network [OSTI]

    Lee, Seung-Kon

    Uniform polymer microbeads with highly loaded quantum dots (QDs) are produced using high-throughput coherent jet breakup of a biocompatible poly(ethylene glycol) diacrylate (PEGDA) prepolymer resin, followed by in-line ...

  15. Evaluation of Tavorite-Structured Cathode Materials for Lithium-Ion Batteries Using High-Throughput Computing

    E-Print Network [OSTI]

    Mueller, Tim

    Cathode materials with structure similar to the mineral tavorite have shown promise for use in lithium-ion batteries, but this class of materials is relatively unexplored. We use high-throughput density-functional-theory ...

  16. High-throughput data mined prediction of inorganic compounds and computational discovery of new lithium-ion battery cathode materials

    E-Print Network [OSTI]

    Hautier, Geoffroy (Geoffroy T. F.)

    2011-01-01T23:59:59.000Z

    The ability to computationally predict the properties of new materials, even prior to their synthesis, has been made possible due to the current accuracy of modern ab initio techniques. In some cases, high-throughput ...

  17. High Throughput Computing Impact on Meta Genomics (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    SciTech Connect (OSTI)

    Gore, Brooklin [Morgridge Institute for Research] [Morgridge Institute for Research

    2011-10-12T23:59:59.000Z

    This presentation includes a brief background on High Throughput Computing, correlating gene transcription factors, optical mapping, genotype to phenotype mapping via QTL analysis, and current work on next gen sequencing.

  18. 2008NaturePublishingGrouphttp://www.nature.com/naturemethods BAC TransgeneOmics: a high-throughput method for

    E-Print Network [OSTI]

    Cai, Long

    to assess protein function at high throughput. Here we describe a fast and reliable pipeline to study ubiquitous or tissue-specific promoters. As a result they do not reproduce the endogenous regulation

  19. High Throughput Computing Impact on Meta Genomics (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    ScienceCinema (OSTI)

    Gore, Brooklin [Morgridge Institute for Research

    2013-01-22T23:59:59.000Z

    This presentation includes a brief background on High Throughput Computing, correlating gene transcription factors, optical mapping, genotype to phenotype mapping via QTL analysis, and current work on next gen sequencing.

  20. Coev2Net: a computational framework for boosting confidence in high-throughput protein-protein interaction datasets

    E-Print Network [OSTI]

    Hosur, Raghavendra

    Improving the quality and coverage of the protein interactome is of tantamount importance for biomedical research, particularly given the various sources of uncertainty in high-throughput techniques. We introduce a ...

  1. Screening system and method of using same

    DOE Patents [OSTI]

    Jones, David A; Gresham, Christopher A; Basiliere, Marc L; Spates, James J; Rodacy, Philip J

    2014-04-15T23:59:59.000Z

    An integrated apparatus and method for screening an object for a target material is provided. The integrated apparatus comprises a housing and an integrated screener. The housing is positionable adjacent the object, and has a channel therethrough. The integrated screener is positionable in the housing, and comprises a fan, at least one filter, a heater and an analyzer. The fan is for drawing air carrying particles and vapor through the channel of the housing. The filter(s) is/are positionable in the channel of the housing for passage of the air therethrough. The filter(s) comprise(s) at least one metal foam having a plurality of pores therein for collecting and adsorbing a sample from the particles and vapor passing therethrough. The heater is for applying heat to the at least one metal foam whereby the collected sample is desorbed from the metal foam. The analyzer detects the target material from the desorbed sample.

  2. Infrared-Based Screening System Oak Ridge National Laboratory

    E-Print Network [OSTI]

    Infrared-Based Screening System (IBSS) Oak Ridge National Laboratory managed by UT-Battelle, LLC underperforming or overworking components are identified. These thermal-based systems integrate infrared (IR) sensors or cameras, video images, and vehicle position sensors, and are generically known as infrared

  3. Solion ion source for high-efficiency, high-throughput solar cell manufacturing

    SciTech Connect (OSTI)

    Koo, John, E-mail: john-koo@amat.com; Binns, Brant; Miller, Timothy; Krause, Stephen; Skinner, Wesley; Mullin, James [Applied Materials, Inc., Varian Semiconductor Equipment Business Unit, 35 Dory Road, Gloucester, Massachusetts 01930 (United States)] [Applied Materials, Inc., Varian Semiconductor Equipment Business Unit, 35 Dory Road, Gloucester, Massachusetts 01930 (United States)

    2014-02-15T23:59:59.000Z

    In this paper, we introduce the Solion ion source for high-throughput solar cell doping. As the source power is increased to enable higher throughput, negative effects degrade the lifetime of the plasma chamber and the extraction electrodes. In order to improve efficiency, we have explored a wide range of electron energies and determined the conditions which best suit production. To extend the lifetime of the source we have developed an in situ cleaning method using only existing hardware. With these combinations, source life-times of >200 h for phosphorous and >100 h for boron ion beams have been achieved while maintaining 1100 cell-per-hour production.

  4. Managing System of Systems Requirements with a Requirements Screening Group

    SciTech Connect (OSTI)

    Ronald R. Barden

    2012-07-01T23:59:59.000Z

    Figuring out an effective and efficient way to manage not only your Requirement’s Baseline, but also the development of all your individual requirements during a Program’s/Project’s Conceptual and Development Life Cycle Stages can be both daunting and difficult. This is especially so when you are dealing with a complex and large System of Systems (SoS) Program with potentially thousands and thousands of Top Level Requirements as well as an equal number of lower level System, Subsystem and Configuration Item requirements that need to be managed. This task is made even more overwhelming when you have to add in integration with multiple requirements’ development teams (e.g., Integrated Product Development Teams (IPTs)) and/or numerous System/Subsystem Design Teams. One solution for tackling this difficult activity on a recent large System of Systems Program was to develop and make use of a Requirements Screening Group (RSG). This group is essentially a Team made up of co-chairs from the various Stakeholders with an interest in the Program of record that are enabled and accountable for Requirements Development on the Program/Project. The RSG co-chairs, often with the help of individual support team, work together as a Program Board to monitor, make decisions on, and provide guidance on all Requirements Development activities during the Conceptual and Development Life Cycle Stages of a Program/Project. In addition, the RSG can establish and maintain the Requirements Baseline, monitor and enforce requirements traceability across the entire Program, and work with other elements of the Program/Project to ensure integration and coordination.

  5. Screening Pumping Systems for Energy Savings Opportunities

    E-Print Network [OSTI]

    Casada, D.

    In most industrial settings, energy consumed by pumping systems is responsible for a major part of the overall electricity bill. In some cases, the energy is used quite efficiently; in others, it is not. Facility operators may be very familiar...

  6. Development of a high-throughput microfluidic integrated microarray for the detection of chimeric bioweapons.

    SciTech Connect (OSTI)

    Sheppod, Timothy; Satterfield, Brent; Hukari, Kyle W.; West, Jason A. A.; Hux, Gary A.

    2006-10-01T23:59:59.000Z

    The advancement of DNA cloning has significantly augmented the potential threat of a focused bioweapon assault, such as a terrorist attack. With current DNA cloning techniques, toxin genes from the most dangerous (but environmentally labile) bacterial or viral organism can now be selected and inserted into robust organism to produce an infinite number of deadly chimeric bioweapons. In order to neutralize such a threat, accurate detection of the expressed toxin genes, rather than classification on strain or genealogical decent of these organisms, is critical. The development of a high-throughput microarray approach will enable the detection of unknowns chimeric bioweapons. The development of a high-throughput microarray approach will enable the detection of unknown bioweapons. We have developed a unique microfluidic approach to capture and concentrate these threat genes (mRNA's) upto a 30 fold concentration. These captured oligonucleotides can then be used to synthesize in situ oligonucleotide copies (cDNA probes) of the captured genes. An integrated microfluidic architecture will enable us to control flows of reagents, perform clean-up steps and finally elute nanoliter volumes of synthesized oligonucleotides probes. The integrated approach has enabled a process where chimeric or conventional bioweapons can rapidly be identified based on their toxic function, rather than being restricted to information that may not identify the critical nature of the threat.

  7. Development and operation of a high-throughput accurate-wavelength lens-based spectrometer

    SciTech Connect (OSTI)

    Bell, Ronald E., E-mail: rbell@pppl.gov [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 (United States)

    2014-11-15T23:59:59.000Z

    A high-throughput spectrometer for the 400–820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm{sup ?1} grating is matched with fast f/1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy ?0.075 arc sec. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount at the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  8. Development and Operation of High-throughput Accurate-wavelength Lens-based Spectrometer

    SciTech Connect (OSTI)

    Bell, Ronald E

    2014-07-01T23:59:59.000Z

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy < 0.075 arc seconds. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount behind the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  9. Learning quantitative sequence-function relationships from high-throughput biological data

    E-Print Network [OSTI]

    Atwal, Gurinder S

    2015-01-01T23:59:59.000Z

    Understanding the transcriptional regulatory code, as well as other types of information encoded within biomolecular sequences, will require learning biophysical models of sequence-function relationships from high-throughput data. Controlling and characterizing the noise in such experiments, however, is notoriously difficult. The unpredictability of such noise creates problems for standard likelihood-based methods in statistical learning, which require that the quantitative form of experimental noise be known precisely. However, when this unpredictability is properly accounted for, important theoretical aspects of statistical learning which remain hidden in standard treatments are revealed. Specifically, one finds a close relationship between the standard inference method, based on likelihood, and an alternative inference method based on mutual information. Here we review and extend this relationship. We also describe its implications for learning sequence-function relationships from real biological data. Fin...

  10. Development and operation of a high-throughput accurate-wavelength lens-based spectrometera)

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bell, Ronald E. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543, USA

    2014-11-01T23:59:59.000Z

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy < 0.075 arc seconds. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount behind the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  11. High throughput ultrasoft x-ray polychromator for embedded impurity pellet injection studies

    SciTech Connect (OSTI)

    Stutman, D.; Finkenthal, M.; Delgado-Aparicio, L.; Tritz, K.; Tamura, N.; Kalinina, D.; Matsubara, A.; Sato, K.; Sudo, S. [Department of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218 (United States); National Institute for Fusion Science, Oroshi-cho 322-6, Toki 509-5292 (Japan); National Institute for Fusion Science, Oroshi-cho 322-6, Toki 509-5292 (Japan); and Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193 (Japan); National Institute for Fusion Science, Oroshi-cho 322-6, Toki 509-5292 (Japan); National Institute for Fusion Science, Oroshi-cho 322-6, Toki 509-5292 (Japan); and Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193 (Japan)

    2005-01-01T23:59:59.000Z

    A prototype ultrasoft x-ray polychromator has been developed for local particle transport measurements in magnetic fusion devices using the H{sub {alpha}} charge exchange emission from low-Z impurity pellets. High throughput together with few cm radial resolution in the plasma are achieved using a toroidally aligned grid collimator, while a few A spectral bandpass together with strong background rejection are obtained using planar multilayer mirrors and foil filters. As high sensitivity detectors we use a new type of compact, efficient and high-gain multichannel plates. The prototype instrument has been evaluated in the laboratory and tested on the Large Helical Device in Japan. In addition to transport studies, this type of device is of interest for next step experiments, where high beam energy and strong attenuation will make visible charge exchange recombination spectroscopy difficult.

  12. Uranium Transport in a High-Throughput Electrorefiner for EBR-II Blanket Fuel

    SciTech Connect (OSTI)

    Ahluwalia, Rajesh K.; Hua, Thanh Q.; Vaden, DeeEarl [Argonne National Laboratory (United States)

    2004-01-15T23:59:59.000Z

    A unique high-throughput Mk-V electrorefiner is being used in the electrometallurgical treatment of the metallic sodium-bonded blanket fuel from the Experimental Breeder Reactor II. Over many cycles, it transports uranium back and forth between the anodic fuel dissolution baskets and the cathode tubes until, because of imperfect adherence of the dendrites, it all ends up in the product collector at the bottom. The transport behavior of uranium in the high-throughput electrorefiner can be understood in terms of the sticking coefficients for uranium adherence to the cathode tubes in the forward direction and to the dissolution baskets in the reverse direction. The sticking coefficients are inferred from the experimental voltage and current traces and are correlated in terms of a single parameter representing the ratio of the cell current to the limiting current at the surface acting as the cathode. The correlations are incorporated into an engineering model that calculates the transport of uranium in the different modes of operation. The model also uses the experimentally derived electrorefiner operating maps that describe the relationship between the cell voltage and the cell current for the three principal transport modes. It is shown that the model correctly simulates the cycle-to-cycle variation of the voltage and current profiles. The model is used to conduct a parametric study of electrorefiner throughput rate as a function of the principal operating parameters. The throughput rate is found to improve with lowering of the basket rotation speed, reduction of UCl{sub 3} concentration in salt, and increasing the maximum cell current or cut-off voltage. Operating conditions are identified that can improve the throughput rate by 60 to 70% over that achieved at present.

  13. Bench-Top Engine System for Fast Screening of Alternative Fuels...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Bench-Top Engine System for Fast Screening of Alternative Fuels and Fuel Additives Bench-Top Engine System for Fast Screening of Alternative Fuels and Fuel Additives A bench-top...

  14. An infrared imaging method for high-throughput combinatorial investigation of hydrogenation-dehydrogenation and new phase

    E-Print Network [OSTI]

    Rubloff, Gary W.

    An infrared imaging method for high-throughput combinatorial investigation of hydrogenation Received 9 April 2009; accepted 30 June 2009; published online 30 July 2009 We have developed an infrared imaging setup enabling in situ infrared images to be acquired, and expanded on capabilities of an infrared

  15. Novel mixed polyanions lithium-ion battery cathode materials predicted by high-throughput ab initio computations

    E-Print Network [OSTI]

    Ceder, Gerbrand

    Novel mixed polyanions lithium-ion battery cathode materials predicted by high-throughput ab initio (>700 Wh/kg) cathode materials for lithium-ion batteries. 1 Introduction The widespread use of lithium-ion monoclinic phase).5 However, the field of lithium-ion batteries is very active, and a large number

  16. A Cross-Referencing-Based Droplet Manipulation Method for High-Throughput and Pin-Constrained Digital Microfluidic Arrays*

    E-Print Network [OSTI]

    Chakrabarty, Krishnendu

    -Constrained Digital Microfluidic Arrays* Tao Xu and Krishnendu Chakrabarty Department of Electrical and Computer Engineering Duke University, Durham, NC 27708, USA {tx, krish}@ee.duke.edu Abstract Digital microfluidic. As high-throughput bioassays are mapped to digital microfluidic platforms, the need for design automation

  17. been the key to their success is the use of high-throughput experiments to assess various zeo-

    E-Print Network [OSTI]

    Silver, Whendee

    it and the resulting pore structure. It could be that the hexamethonium molecules pack in such a way as to providebeen the key to their success is the use of high- throughput experiments to assess various zeo and shape of the resulting pores cor- responds to the size and shape of the organic molecule. ITQ-33

  18. GeoChip 3.0: A High Throughput Tool for Analyzing Microbial Community, Composition, Structure, and Functional Activity

    SciTech Connect (OSTI)

    He, Zhili; Deng, Ye; Nostrand, Joy Van; Tu, Qichao; Xu, Meiying; Hemme, Chris; Wu, Liyou; Hazen, Terry; Zhou, Jizhong; Li, Xingyuan; Gentry, Terry; Yin, Yifeng; Liebich, Jost

    2010-05-17T23:59:59.000Z

    Microarray-based genomic technology has been widely used for microbial community analysis, and it is expected that microarray-based genomic technologies will revolutionize the analysis of microbial community structure, function and dynamics. A new generation of functional gene arrays (GeoChip 3.0) has been developed, with 27,812 probes covering 56,990 gene variants from 292 functional gene families involved in carbon, nitrogen, phosphorus and sulfur cycles, energy metabolism, antibiotic resistance, metal resistance, and organic contaminant degradation. Those probes were derived from 2,744, 140, and 262 species for bacteria, archaea, and fungi, respectively. GeoChip 3.0 has several other distinct features, such as a common oligo reference standard (CORS) for data normalization and comparison, a software package for data management and future updating, and the gyrB gene for phylogenetic analysis. Our computational evaluation of probe specificity indicated that all designed probes had a high specificity to their corresponding targets. Also, experimental analysis with synthesized oligonucleotides and genomic DNAs showed that only 0.0036percent-0.025percent false positive rates were observed, suggesting that the designed probes are highly specific under the experimental conditions examined. In addition, GeoChip 3.0 was applied to analyze soil microbial communities in a multifactor grassland ecosystem in Minnesota, USA, which demonstrated that the structure, composition, and potential activity of soil microbial communities significantly changed with the plant species diversity. All results indicate that GeoChip 3.0 is a high throughput powerful tool for studying microbial community functional structure, and linking microbial communities to ecosystem processes and functioning. To our knowledge, GeoChip 3.0 is the most comprehensive microarrays currently available for studying microbial communities associated with geobiochemical cycling, global climate change, bioenergy, agricuture, land use, ecosystem management, environmental cleanup and restoration, bioreactor systems, and human health.

  19. High-throughput liquid-absorption air-sampling apparatus and methods

    DOE Patents [OSTI]

    Zaromb, Solomon (95706 William Dr., Hinsdale, IL 60521)

    2000-01-01T23:59:59.000Z

    A portable high-throughput liquid-absorption air sampler [PHTLAAS] has an asymmetric air inlet through which air is drawn upward by a small and light-weight centrifugal fan driven by a direct current motor that can be powered by a battery. The air inlet is so configured as to impart both rotational and downward components of motion to the sampled air near said inlet. The PHTLAAS comprises a glass tube of relatively small size through which air passes at a high rate in a swirling, highly turbulent motion, which facilitates rapid transfer of vapors and particulates to a liquid film covering the inner walls of the tube. The pressure drop through the glass tube is <10 cm of water, usually <5 cm of water. The sampler's collection efficiency is usually >20% for vapors or airborne particulates in the 2-3.mu. range and >50% for particles larger than 4.mu.. In conjunction with various analyzers, the PHTLAAS can serve to monitor a variety of hazardous or illicit airborne substances, such as lead-containing particulates, tritiated water vapor, biological aerosols, or traces of concealed drugs or explosives.

  20. automated high-throughput platform: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of the Geniom Biochip for specific elongation and labeling Cai, Long 52 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites...

  1. array-based high throughput: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roehm, Uwe 2009-01-01 13 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...

  2. aureus strains high-throughput: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roehm, Uwe 2009-01-01 14 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...

  3. antileishmanial high-throughput drug: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roehm, Uwe 2009-01-01 22 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...

  4. The Development of Microfabricated Microbial Fuel Cell Array as a High Throughput Screening Platform for Electrochemically Active Microbes

    E-Print Network [OSTI]

    Hou, Huijie

    2012-02-14T23:59:59.000Z

    Microbial fuel cells (MFCs) are novel green technologies that convert chemical energy stored in biomass into electricity through microbial metabolisms. Both fossil fuel depletion and environmental concern have fostered significant interest in MFCs...

  5. A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus

    E-Print Network [OSTI]

    Chung, Dong-Hoon; Moore, Blake P.; Matharu, Daljit S.; Golden, Jennifer E.; Maddox, Clinton; Rasmussen, Lynn; Sosa, Melinda I.; Ananthan, Subramaniam; White, E. Lucile; Jia, Fuli; Jonsson, Colleen B.; Severson, William E.

    2013-01-10T23:59:59.000Z

    Background: Human respiratory syncytial virus (hRSV) is a highly contagious pathogen and is the most common cause of bronchiolitis and pneumonia for infants and children under one year of age. Worldwide, greater than 33 ...

  6. High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons

    E-Print Network [OSTI]

    Nieland, Thomas J.

    The formation of synapses, the specialized points of chemical communication between neurons, is a highly regulated developmental process fundamental to establishing normal brain circuitry. Perturbations of synapse formation ...

  7. Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway

    E-Print Network [OSTI]

    Wu, Kai Connie; McDonald, Peter R.; Liu, Jie Jerry; Chaguturu, Rathnam; Klaassen, Curtis D.

    2012-10-08T23:59:59.000Z

    Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes involved in antioxidant defense through binding to Antioxidant Response Elements (ARE) located in the promoter regions...

  8. High-Throughput Screening of Mg-Functionalized Metal-Organic Frameworks for Hydrogen Storage near Room Temperature

    E-Print Network [OSTI]

    Colón, Yamil J.; Fairen-Jimenez, David; Wilmer, Christopher E.; Snurr, Randall Q.

    2014-01-01T23:59:59.000Z

    The hydrogen storage capabilities of 18,383 porous crystalline structures possessing various degrees of Mg functionalization and diverse physical properties were assessed through combined grand canonical Monte Carlo (GCMC) and quantum mechanical...

  9. A Cell-Based High-Throughput Screen for Novel Chemical Inducers of Fetal Hemoglobin for Treatment of Hemoglobinopathies

    E-Print Network [OSTI]

    Peterson, Kenneth R.; Costa, Flá via C.; Fedosyuk, Halyna; Neades, Renee Y.; Chazelle, Allen M.; Zelenchuk, Lesya; Fonteles, Andrea H.; Dalal, Parmita; Roy, Anuradha; Chaguturu, Rathnam; Li, Biaoru; Pace, Betty S.

    2014-09-16T23:59:59.000Z

    S (1997) Mechanism of action of hydroxyurea in the management of sickle cell anemia in adults. Semin Hematol 34(3 Suppl 3): 15–21. 5. Steinberg MH, Lu ZH, Barton FB, Terrin ML, Charache S, et al. (1997) Fetal hemoglobin in sickle cell anemia: determinants...

  10. Development of High-Throughput Screens to Target SAM-I Riboswitches (2014 DOE JGI Genomics of Energy & Environment Meeting)

    SciTech Connect (OSTI)

    Hickey, Scott [UC Berkely

    2014-03-19T23:59:59.000Z

    Scott Hickey of the University of California Berkeley speaks at the 9th Annual Genomics of Energy & Environment Meeting on March 20, 2014 in Walnut Creek, Calif.

  11. Screening portal, system and method of using same

    DOE Patents [OSTI]

    Linker, Kevin L.; Hunter, John A.; Brusseau, Charles A.

    2013-04-30T23:59:59.000Z

    A portal, system and method for screening an object for a target substance is provided. The portal includes an inflatable bladder expandable to form a test space for receiving the object and a plurality of nozzles positioned about the inflatable bladder. The nozzles are in fluid communication with a fluid source for directing air over the object whereby samples are removed from the object for examination. A collector is operatively connected to the inflatable bladder for collecting the samples removed from the object. A detector is operatively connected to the collector for examining the removed samples for the presence of the target substance. At least one preconcentrator may be operatively connected to the collector for concentrating the samples collected thereby.

  12. Artificial light and quantum order in systems of screened dipoles Xiao-Gang Wen

    E-Print Network [OSTI]

    Wen, Xiao-Gang

    Artificial light and quantum order in systems of screened dipoles Xiao-Gang Wen Department discussed. The existence of artificial light (as well as artificial electron) in condensed matter systems a new kind of order - quantum order. To test this idea in experiments, we study systems of screened

  13. A Screening Model to Explore Planning Decisions in Automotive Manufacturing Systems under Demand Uncertainty

    E-Print Network [OSTI]

    de Weck, Olivier L.

    In White assembly systems in the automotive industry by applying the developed screening model. It shows3 A Screening Model to Explore Planning Decisions in Automotive Manufacturing Systems under Demand engineering systems, as for automotive manufacturing, often require significant capital investment

  14. High-Throughput Genetic Analysis and Combinatorial Chiral Separations Based on Capillary Electrophoresis

    SciTech Connect (OSTI)

    Wenwan Zhong

    2003-08-05T23:59:59.000Z

    Capillary electrophoresis (CE) offers many advantages over conventional analytical methods, such as speed, simplicity, high resolution, low cost, and small sample consumption, especially for the separation of enantiomers. However, chiral method developments still can be time consuming and tedious. They designed a comprehensive enantioseparation protocol employing neutral and sulfated cyclodextrins as chiral selectors for common basic, neutral, and acidic compounds with a 96-capillary array system. By using only four judiciously chosen separation buffers, successful enantioseparations were achieved for 49 out of 54 test compounds spanning a large variety of pKs and structures. Therefore, unknown compounds can be screened in this manner to identify optimal enantioselective conditions in just one rn. In addition to superior separation efficiency for small molecules, CE is also the most powerful technique for DNA separations. Using the same multiplexed capillary system with UV absorption detection, the sequence of a short DNA template can be acquired without any dye-labels. Two internal standards were utilized to adjust the migration time variations among capillaries, so that the four electropherograms for the A, T, C, G Sanger reactions can be aligned and base calling can be completed with a high level of confidence. the CE separation of DNA can be applied to study differential gene expression as well. Combined with pattern recognition techniques, small variations among electropherograms obtained by the separation of cDNA fragments produced from the total RNA samples of different human tissues can be revealed. These variations reflect the differences in total RNA expression among tissues. Thus, this Ce-based approach can serve as an alternative to the DNA array techniques in gene expression analysis.

  15. Integrated crystal mounting and alignment system for high-throughput biological crystallography

    DOE Patents [OSTI]

    Nordmeyer, Robert A. (San Leandro, CA); Snell, Gyorgy P. (Richmond, CA); Cornell, Earl W. (Antioch, CA); Kolbe, William F. (Moraga, CA); Yegian, Derek T. (Oakland, CA); Earnest, Thomas N. (Berkeley, CA); Jaklevich, Joseph M. (Lafayette, CA); Cork, Carl W. (Walnut Creek, CA); Santarsiero, Bernard D. (Chicago, IL); Stevens, Raymond C. (La Jolla, CA)

    2007-09-25T23:59:59.000Z

    A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.

  16. Integrated crystal mounting and alignment system for high-throughput biological crystallography

    DOE Patents [OSTI]

    Nordmeyer, Robert A.; Snell, Gyorgy P.; Cornell, Earl W.; Kolbe, William; Yegian, Derek; Earnest, Thomas N.; Jaklevic, Joseph M.; Cork, Carl W.; Santarsiero, Bernard D.; Stevens, Raymond C.

    2005-07-19T23:59:59.000Z

    A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.

  17. Application of High Throughput Pretreatment and Co-Hydrolysis System to Thermochemical

    E-Print Network [OSTI]

    California at Riverside, University of

    Introduction Sustainable energy sources are needed to supplement petroleum use in light of limited reserves economically, a large number of factors such as feedstock quality, conversion conditions, and catalyst loadings as well as their complex interactions must be better evaluated to identify combina- tions that can

  18. New Challenges of the Computation of Multiple Sequence Alignments in the High-Throughput Era (2010 JGI/ANL HPC Workshop)

    ScienceCinema (OSTI)

    Notredame, Cedric [Centre for Genomic Regulation

    2011-06-08T23:59:59.000Z

    Cedric Notredame from the Centre for Genomic Regulation gives a presentation on "New Challenges of the Computation of Multiple Sequence Alignments in the High-Throughput Era" at the JGI/Argonne HPC Workshop on January 26, 2010.

  19. Artificial light and quantum order in systems of screened dipoles

    E-Print Network [OSTI]

    Xiao-Gang Wen

    2003-04-14T23:59:59.000Z

    The origin of light is a unsolved mystery in nature. Recently, it was suggested that light may originate from a new kind of order - quantum order. To test this idea in experiments, we study systems of screened magnetic/electric dipoles in 2D and 3D lattices. We show that our models contain an artificial light -- a photon-like collective excitation. We discuss how to design realistic devices that realize our models. We show that the ``speed of light'' and the ``fine structure constant'' of the artificial light can be tuned in our models. The properties of artificial atoms (bound states of pairs of artificial charges) are also discussed. The existence of artificial light (as well as artificial electron) in condensed matter systems suggests that elementary particles, such as light and electron, may not be elementary. They may be collective excitations of quantum order in our vacuum. Our models further suggest that a gauge theory is a string-net theory in disguise. Light is a fluctuation of nets of large closed strings and charge is the end of open strings.

  20. Definition, Expansion and Screening of Architectures for Planetary Exploration Class Nuclear Electric Propulsion and Power Systems

    E-Print Network [OSTI]

    Nuclear Electric Propulsion and Power Systems By Bryan K. Smith Submitted to the System Design, expansion and screening of Nuclear Electric Propulsion and Power concepts capable of achieving planetaryDefinition, Expansion and Screening of Architectures for Planetary Exploration Class Nuclear

  1. Equivalence Principle Violation in Weakly Vainshtein-Screened Systems Alexander V. Belikov1

    E-Print Network [OSTI]

    Hu, Wayne

    Equivalence Principle Violation in Weakly Vainshtein-Screened Systems Alexander V. Belikov1-dependent interactions cause apparent equivalence principle vi- olations. In the weakly-screened regime violations can [17­23]. In these models, all bodies accelerate equivalently in the total field of the fifth force

  2. High-throughput characterization of stresses in thin film materials libraries using Si cantilever array wafers and digital holographic microscopy

    SciTech Connect (OSTI)

    Lai, Y. W.; Ludwig, A. [Institute for Materials, Chair for Materials for Microsystems, Ruhr-Universitaet Bochum, 44780 Bochum (Germany); Materials Research Department, Ruhr-Universitaet Bochum, 44780 Bochum (Germany); Hamann, S.; Ehmann, M. [Institute for Materials, Chair for Materials for Microsystems, Ruhr-Universitaet Bochum, 44780 Bochum (Germany)

    2011-06-15T23:59:59.000Z

    We report the development of an advanced high-throughput stress characterization method for thin film materials libraries sputter-deposited on micro-machined cantilever arrays consisting of around 1500 cantilevers on 4-inch silicon-on-insulator wafers. A low-cost custom-designed digital holographic microscope (DHM) is employed to simultaneously monitor the thin film thickness, the surface topography and the curvature of each of the cantilevers before and after deposition. The variation in stress state across the thin film materials library is then calculated by Stoney's equation based on the obtained radii of curvature of the cantilevers and film thicknesses. DHM with nanometer-scale out-of-plane resolution allows stress measurements in a wide range, at least from several MPa to several GPa. By using an automatic x-y translation stage, the local stresses within a 4-inch materials library are mapped with high accuracy within 10 min. The speed of measurement is greatly improved compared with the prior laser scanning approach that needs more than an hour of measuring time. A high-throughput stress measurement of an as-deposited Fe-Pd-W materials library was evaluated for demonstration. The fast characterization method is expected to accelerate the development of (functional) thin films, e.g., (magnetic) shape memory materials, whose functionality is greatly stress dependent.

  3. Attendees list from the U.S. Department of Energy's High Throughput

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation Ahern, Michael WorcesterScreening

  4. Six-flow operations for catalyst development in Fischer-Tropsch synthesis: Bridging the gap between high-throughput experimentation and extensive product evaluation

    SciTech Connect (OSTI)

    Sartipi, Sina, E-mail: S.Sartipi@tudelft.nl, E-mail: J.Gascon@tudelft.nl; Jansma, Harrie; Bosma, Duco; Boshuizen, Bart; Makkee, Michiel; Gascon, Jorge, E-mail: S.Sartipi@tudelft.nl, E-mail: J.Gascon@tudelft.nl; Kapteijn, Freek [Department of Chemical Engineering, Catalysis Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft (Netherlands)] [Department of Chemical Engineering, Catalysis Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft (Netherlands)

    2013-12-15T23:59:59.000Z

    Design and operation of a “six-flow fixed-bed microreactor” setup for Fischer-Tropsch synthesis (FTS) is described. The unit consists of feed and mixing, flow division, reaction, separation, and analysis sections. The reactor system is made of five heating blocks with individual temperature controllers, assuring an identical isothermal zone of at least 10 cm along six fixed-bed microreactor inserts (4?mm inner diameter). Such a lab-scale setup allows running six experiments in parallel, under equal feed composition, reaction temperature, and conditions of separation and analysis equipment. It permits separate collection of wax and liquid samples (from each flow line), allowing operation with high productivities of C5+ hydrocarbons. The latter is crucial for a complete understanding of FTS product compositions and will represent an advantage over high-throughput setups with more than ten flows where such instrumental considerations lead to elevated equipment volume, cost, and operation complexity. The identical performance (of the six flows) under similar reaction conditions was assured by testing a same catalyst batch, loaded in all microreactors.

  5. Scheduling screening inspections for replaceable and non-replaceable systems

    E-Print Network [OSTI]

    Aral, Bahadir

    2009-05-15T23:59:59.000Z

    . For instance, the American Cancer Society recommends three tests to detect signs of breast cancer: mammography, clinical breast exam and breast self-examination. Additionally, the American Medical Womens Association recommends annual mammography and clin- ical... cancer. For instance, mammography?s ability to detect a breast cancer when it is already started is estimated to 77.6% in (Houssami, Ciatto, Irwig, Simpson and Macaskill, 2002). Therefore, when designing screening inspection schedules, the fallibility...

  6. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

    2014-01-01T23:59:59.000Z

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: • A novel computational framework was developed for mechanistic study of SADRs. • Off-targets of drugs were identified in large scale and in a high-throughput manner. • SADRs like cardiac disorders were systematically explored in molecular networks. • A number of ADR-associated proteins were identified.

  7. High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury

    SciTech Connect (OSTI)

    Wills, Lauren P. [MitoHealth Inc., Charleston, SC 29403 (United States); Beeson, Gyda C.; Trager, Richard E.; Lindsey, Christopher C. [Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425 (United States); Beeson, Craig C. [MitoHealth Inc., Charleston, SC 29403 (United States); Peterson, Yuri K. [Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425 (United States); Schnellmann, Rick G., E-mail: schnell@musc.edu [Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425 (United States); Ralph H. Johnson VA Medical Center, Charleston, SC 29401 (United States)

    2013-10-15T23:59:59.000Z

    Many environmental chemicals and drugs negatively affect human health through deleterious effects on mitochondrial function. Currently there is no chemical library of mitochondrial toxicants, and no reliable methods for predicting mitochondrial toxicity. We hypothesized that discrete toxicophores defined by distinct chemical entities can identify previously unidentified mitochondrial toxicants. We used a respirometric assay to screen 1760 compounds (5 ?M) from the LOPAC and ChemBridge DIVERSet libraries. Thirty-one of the assayed compounds decreased uncoupled respiration, a stress test for mitochondrial dysfunction, prior to a decrease in cell viability and reduced the oxygen consumption rate in isolated mitochondria. The mitochondrial toxicants were grouped by chemical similarity and two clusters containing four compounds each were identified. Cheminformatic analysis of one of the clusters identified previously uncharacterized mitochondrial toxicants from the ChemBridge DIVERSet. This approach will enable the identification of mitochondrial toxicants and advance the prediction of mitochondrial toxicity for both drug discovery and risk assessment. - Highlights: • Respirometric assay conducted in RPTC to create mitochondrial toxicant database. • Chemically similar mitochondrial toxicants aligned as mitochondrial toxicophores • Mitochondrial toxicophore identifies five novel mitochondrial toxicants.

  8. A microfluidics approach towards high-throughput pathogen removal from blood using margination

    E-Print Network [OSTI]

    Hou, Han Wei

    Sepsis is an adverse systemic inflammatory response caused by microbial infection in blood. This paper reports a simple microfluidic approach for intrinsic, non-specific removal of both microbes and inflammatory cellular ...

  9. A high-throughput, high-resolution spectrometer for mapping the heliopause and 3-D Solar Wind using He+ 30.4nm

    E-Print Network [OSTI]

    California at Berkeley, University of

    A high-throughput, high-resolution spectrometer for mapping the heliopause and 3-D Solar Wind using Entrance slit farm with ~ 1000 slits Photon counting imager Concave grating used near normal incidence >> Need a higher throughput diffuse EUV spectrometer solar wind respond to coronal

  10. Exploring Flexible Strategies in Engineering Systems Using Screening Models Applications to Offshore Petroleum Projects

    E-Print Network [OSTI]

    de Weck, Olivier L.

    , such as offshore petroleum exploration and production systems, generally require a significant amount of capital to Offshore Petroleum Projects by Jijun Lin B.E., Mechanical Engineering, Beijing University of Aeronautics Flexible Strategies in Engineering Systems Using Screening Models Applications to Offshore Petroleum

  11. Screening for Real Options “In” an Engineering System: A Step Towards Flexible System Development

    E-Print Network [OSTI]

    Bartolomei, Jason E.

    2006-04-07T23:59:59.000Z

    The goal of this research is to develop an analytical framework for screening for real options “in” an

  12. BioSAXS Sample Changer: a robotic sample changer for rapid and reliable high-throughput X-ray solution scattering experiments

    SciTech Connect (OSTI)

    Round, Adam, E-mail: around@embl.fr; Felisaz, Franck [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Université Grenoble Alpes–EMBL–CNRS, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Fodinger, Lukas; Gobbo, Alexandre [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Huet, Julien [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Université Grenoble Alpes–EMBL–CNRS, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Villard, Cyril [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Blanchet, Clement E., E-mail: around@embl.fr [EMBL c/o DESY, Notkestrasse 85, 22603 Hamburg (Germany); Pernot, Petra; McSweeney, Sean [ESRF, 6 Rue Jules Horowitz, 38000 Grenoble (France); Roessle, Manfred; Svergun, Dmitri I. [EMBL c/o DESY, Notkestrasse 85, 22603 Hamburg (Germany); Cipriani, Florent, E-mail: around@embl.fr [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Université Grenoble Alpes–EMBL–CNRS, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France)

    2015-01-01T23:59:59.000Z

    A robotic sample changer for solution X-ray scattering experiments optimized for speed and to use the minimum amount of material has been developed. This system is now in routine use at three high-brilliance European synchrotron sites, each capable of several hundred measurements per day. Small-angle X-ray scattering (SAXS) of macromolecules in solution is in increasing demand by an ever more diverse research community, both academic and industrial. To better serve user needs, and to allow automated and high-throughput operation, a sample changer (BioSAXS Sample Changer) that is able to perform unattended measurements of up to several hundred samples per day has been developed. The Sample Changer is able to handle and expose sample volumes of down to 5 ”l with a measurement/cleaning cycle of under 1 min. The samples are stored in standard 96-well plates and the data are collected in a vacuum-mounted capillary with automated positioning of the solution in the X-ray beam. Fast and efficient capillary cleaning avoids cross-contamination and ensures reproducibility of the measurements. Independent temperature control for the well storage and for the measurement capillary allows the samples to be kept cool while still collecting data at physiological temperatures. The Sample Changer has been installed at three major third-generation synchrotrons: on the BM29 beamline at the European Synchrotron Radiation Facility (ESRF), the P12 beamline at the PETRA-III synchrotron (EMBL@PETRA-III) and the I22/B21 beamlines at Diamond Light Source, with the latter being the first commercial unit supplied by Bruker ASC.

  13. In vivo robotics: the automation of neuroscience and other intact-system biological fields

    E-Print Network [OSTI]

    Forest, Craig R.

    Robotic and automation technologies have played a huge role in in vitro biological science, having proved critical for scientific endeavors such as genome sequencing and high-throughput screening. Robotic and automation ...

  14. Systems level characterizations of single and combination drug mechanisms of action in vitro and in vivo

    E-Print Network [OSTI]

    Pritchard, Justin (Justin Robert)

    2012-01-01T23:59:59.000Z

    Small molecule characterization is a critical limiting step in cancer drug development. At the present time, high throughput screens of natural products and combinatorial synthesis libraries generate more pharmaceutical ...

  15. On-the-fly machine-learning for high-throughput experiments: search for rare-earth-free permanent magnets

    SciTech Connect (OSTI)

    Kusne, Aaron Gilad [University of Maryland; Gao, Tieren [University of Maryland; Mehta, Apurva [SLAC National Accelerator Laboratory; Ke, Liqin [Ames Laboratory; Nguyen, Manh Cuong [Ames Laboratory; Ho, Kai-Ming [Ames Laboratory; Antropov, Vladimir [Ames Laboratory; Wang, Cai-Zhuang [Ames Laboratory; Kramer, Matthew J [Ames Laboratory; Long, Christian [University of Maryland; Takeuchi, Ichiro [University of Maryland

    2014-09-15T23:59:59.000Z

    Advanced materials characterization techniques with ever-growing data acquisition speed and storage capabilities represent a challenge in modern materials science, and new procedures to quickly assess and analyze the data are needed. Machine learning approaches are effective in reducing the complexity of data and rapidly homing in on the underlying trend in multi-dimensional data. Here, we show that by employing an algorithm called the mean shift theory to a large amount of diffraction data in high-throughput experimentation, one can streamline the process of delineating the structural evolution across compositional variations mapped on combinatorial libraries with minimal computational cost. Data collected at a synchrotron beamline are analyzed on the fly, and by integrating experimental data with the inorganic crystal structure database (ICSD), we can substantially enhance the accuracy in classifying the structural phases across ternary phase spaces. We have used this approach to identify a novel magnetic phase with enhanced magnetic anisotropy which is a candidate for rare-earth free permanent magnet.

  16. Ionospheric Threat Mitigation by Geometry Screening in Ground-Based Augmentation Systems

    E-Print Network [OSTI]

    Stanford University

    Ionospheric Threat Mitigation by Geometry Screening in Ground-Based Augmentation Systems Jiyun Lee observed during severe ionospheric storms pose potential threats to the integrity of the Ground threats, because ionospheric gradients are not observable to the ground monitor if they impact

  17. Assessment of advanced coal-gasification processes. [AVCO high throughput gasification in process; Bell High Mass Flux process; CS-R process; and Exxon Gasification process

    SciTech Connect (OSTI)

    McCarthy, J.; Ferrall, J.; Charng, T.; Houseman, J.

    1981-06-01T23:59:59.000Z

    This report represents a technical assessment of the following advanced coal gasification processes: AVCO High Throughput Gasification (HTG) Process, Bell Single - Stage High Mass Flux (HMF) Process, Cities Service/Rockwell (CS/R) Hydrogasification Process, and the Exxon Catalytic Coal Gasification (CCG) Process. Each process is evaluated for its potential to produce SNG from a bituminous coal. In addition to identifying the new technology these processes represent, key similarities/differences, strengths/weaknesses, and potential improvements to each process are identified. The AVCO HTG and the Bell HMF gasifiers share similarities with respect to: short residence time (SRT), high throughput rate, slagging and syngas as the initial raw product gas. The CS/R Hydrogasifier is also SRT but is non-slagging and produces a raw gas high in methane content. The Exxon CCG gasifier is a long residence time, catalytic fluidbed reactor producing all of the raw product methane in the gasifier.

  18. Screening study on high temperature energy transport systems

    SciTech Connect (OSTI)

    Graves, R.L.

    1980-10-01T23:59:59.000Z

    The purpose of the study described in this document is to identify the options for transporting thermal energy over long distances. The study deals specifically and exclusively with high temperature (> 400/sup 0/C(752/sup 0/F)) energy for industrial use. Energy transport is seen as a potential solution to: high unit cost of small coal and nuclear steam generators, and opposition to siting of coal or nuclear plants near populated areas. The study is of a preliminary nature but covers many options including steam, molten salts, organics, and chemical heat pipes. The development status and potential problems of these and other energy transport methods are discussed. Energy transport concepts are compared on a fundamental level based on physical properties and also are subjected to an economic study. The economic study indicated that the chemical heat pipe, under a specific set of circumstances, appeared to be the least expensive for distances greater than about 32 km (20 miles). However, if the temperature of the energy was lowered, the heat transfer salt (sodium nitrate/nitrite) system would apparently be a better economic choice for less than about 80 km (50 miles). None of the options studied appear to be more attractive than small coal-fired boilers when the transport distance is over about 64 km (40 miles). Several recommendations are made for refining the analysis.

  19. Apparatus for combinatorial screening of electrochemical materials

    DOE Patents [OSTI]

    A high throughput combinatorial screening method and apparatus for the evaluation of electrochemical materials using a single voltage source (2) is disclosed wherein temperature changes arising from the application of an electrical load to a cell array (1) are used to evaluate the relative electrochemical efficiency of the materials comprising the array. The apparatus may include an array of electrochemical cells (1) that are connected to each other in parallel or in series, an electronic load (2) for applying a voltage or current to the electrochemical cells (1), and a device (3), external to the cells, for monitoring the relative temperature of each cell when the load is applied.

    2009-12-15T23:59:59.000Z

    A high throughput combinatorial screening method and apparatus for the evaluation of electrochemical materials using a single voltage source (2) is disclosed wherein temperature changes arising from the application of an electrical load to a cell array (1) are used to evaluate the relative electrochemical efficiency of the materials comprising the array. The apparatus may include an array of electrochemical cells (1) that are connected to each other in parallel or in series, an electronic load (2) for applying a voltage or current to the electrochemical cells (1), and a device (3), external to the cells, for monitoring the relative temperature of each cell when the load is applied.

  20. Plasma Screen Floating Mount

    DOE Patents [OSTI]

    Eakle, Robert F. (New Ellenton, SC); Pak, Donald J. (Martine, GA)

    2004-10-26T23:59:59.000Z

    A mounting system for a flat display screen, particularly a plasma display screen, suspends the screen separately in each of the x-, y- and z-directions. A series of frames located by linear bearings and isolated by springs and dampers allows separate controlled movement in each axis. The system enables the use of relatively larger display screens in vehicles in which plasma screen are subject to damage from vibration.

  1. Comparative performance of modern digital mammography systems in a large breast screening program

    SciTech Connect (OSTI)

    Yaffe, Martin J., E-mail: martin.yaffe@sri.utoronto.ca; Bloomquist, Aili K.; Hunter, David M.; Mawdsley, Gordon E. [Physical Sciences Division, Sunnybrook Research Institute, Departments of Medical Biophysics and Medical Imaging, University of Toronto, Ontario M4N 3M5 (Canada)] [Physical Sciences Division, Sunnybrook Research Institute, Departments of Medical Biophysics and Medical Imaging, University of Toronto, Ontario M4N 3M5 (Canada); Chiarelli, Anna M. [Prevention and Cancer Control, Cancer Care Ontario, Dalla Lana School of Public Health, University of Toronto, Ontario M4N 3M5, Canada and Ontario Breast Screening Program, Cancer Care Ontario, Toronto, Ontario M5G 1X3 (Canada)] [Prevention and Cancer Control, Cancer Care Ontario, Dalla Lana School of Public Health, University of Toronto, Ontario M4N 3M5, Canada and Ontario Breast Screening Program, Cancer Care Ontario, Toronto, Ontario M5G 1X3 (Canada); Muradali, Derek [Ontario Breast Screening Program, Cancer Care Ontario, Toronto, Ontario M5G 1X3 (Canada)] [Ontario Breast Screening Program, Cancer Care Ontario, Toronto, Ontario M5G 1X3 (Canada); Mainprize, James G. [Physical Sciences Division, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5 (Canada)] [Physical Sciences Division, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5 (Canada)

    2013-12-15T23:59:59.000Z

    Purpose: To compare physical measures pertaining to image quality among digital mammography systems utilized in a large breast screening program. To examine qualitatively differences in these measures and differences in clinical cancer detection rates between CR and DR among sites within that program. Methods: As part of the routine quality assurance program for screening, field measurements are made of several variables considered to correlate with the diagnostic quality of medical images including: modulation transfer function, noise equivalent quanta, d? (an index of lesion detectability) and air kerma to allow estimation of mean glandular dose. In addition, images of the mammography accreditation phantom are evaluated. Results: It was found that overall there were marked differences between the performance measures of DR and CR mammography systems. In particular, the modulation transfer functions obtained with the DR systems were found to be higher, even for larger detector element sizes. Similarly, the noise equivalent quanta, d?, and the phantom scores were higher, while the failure rates associated with low signal-to-noise ratio and high dose were lower with DR. These results were consistent with previous findings in the authors’ program that the breast cancer detection rates at sites employing CR technology were, on average, 30.6% lower than those that used DR mammography. Conclusions: While the clinical study was not large enough to allow a statistically powered system-by-system assessment of cancer detection accuracy, the physical measures expressing spatial resolution, and signal-to-noise ratio are consistent with the published finding that sites employing CR systems had lower cancer detection rates than those using DR systems for screening mammography.

  2. 676 Combinatorial Chemistry & High Throughput Screening, 2007, 10, 676-697 1386-2073/07 $50.00+.00 2007 Bentham Science Publishers Ltd.

    E-Print Network [OSTI]

    Powers, Robert

    .00+.00 © 2007 Bentham Science Publishers Ltd. Functional Genomics and NMR Spectroscopy Robert Powers* Department genome project and the continued accomplishment in obtaining DNA se- quences for a vast array- nome-wide functional annotation (functional genomics) has evolved as the necessary next step. Nuclear

  3. Advances in High-Throughput Screening for Drug Discovery The UIC Center for Clinical and Translational Science is sponsoring a translational technology symposium on

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    the Harvard/MIT Broad Institute, Sam Michael, from the NIH Chemical Genomics Center, Annie Mak, from the Genomics Institute of the Novartis Research Foundation, and Marcie Glicksman, from the Harvard Neuro-Scanning-Coupled Microscopy Sam Michael, Group Leader, Automation and Compound Management, NIH Chemical Genomics Center 11

  4. Combinatorial Chemistry & High Throughput Screening, 2010, 13, 67-74 67 1386-2073/10 $55.00+.00 2010 Bentham Science Publishers Ltd.

    E-Print Network [OSTI]

    Senkan, Selim M.

    for the Direct Epoxidation of Propylene Michael Kahn1 , Anusorn Seubsai1 , Isik Onal2 and Selim Senkan*,1 1 activities and selectivities for the partial oxidation of propylene, in particular for propylene oxide (PO catalysis, partial oxidation, laser ablation, nanoparticles, array micro-reactors. 1. INTRODUCTION Propylene

  5. Combinatorial Chemistry & High Throughput Screening, 2006, 9, 247-257 247 1386-2073/06 $50.00+.00 2006 Bentham Science Publishers Ltd.

    E-Print Network [OSTI]

    Zhao, Huimin

    and pharmaceutical intermediates. Their low environmental impact is also attractive: enzymes are drawn from renewable,2]. The majority of industrial enzymes (65%) are used in technical applications by the detergent, starch, textile

  6. Combinatorial Chemistry & High Throughput Screening, 2007, 10, 111-119 111 1386-2073/07 $50.00+.00 2007 Bentham Science Publishers Ltd.

    E-Print Network [OSTI]

    Senkan, Selim M.

    chemicals and intermediates [1]. For example, propylene can be converted into acrolein and acrylic acid carbons are weaker, propylene readily is oxidized to acrolein and to acrylic acid rather than

  7. Capillary Flow Layer-by-Layer: A Microfluidic Platform for the High-Throughput Assembly and Screening of Nanolayered Film Libraries

    E-Print Network [OSTI]

    Castleberry, Steven A.

    Layer-by-layer (LbL) assembly is a powerful tool with increasing real world applications in energy, biomaterials, active surfaces, and membranes; however, the current state of the art requires individual sample construction ...

  8. Development of Quantitative FRET Technology for SENP Enzyme Kinetics Determinations and High-Sensitive High-Throughput Screening Assay for Protease Inhibitor Discovery

    E-Print Network [OSTI]

    Liu, Yan

    2012-01-01T23:59:59.000Z

    of lanthanides such as europium as the donor probe, time-studies . Since the europium probe has a much longerFRET assays are terbium and europium. Terbium offers unique

  9. High-throughput system can analyze thousands of poplar, maize, and switch grass samples at a time to help determine

    E-Print Network [OSTI]

    to help determine which biomass feedstocks are best suited for biofuels. Researchers at the National

  10. Use of Time-Aggregated Data in Economic Screening Analyses of Combined Heat and Power Systems

    SciTech Connect (OSTI)

    Hudson II, Carl Randy [ORNL

    2004-09-01T23:59:59.000Z

    Combined heat and power (CHP) projects (also known as cogeneration projects) usually undergo a series of assessments and viability checks before any commitment is made. A screening analysis, with electrical and thermal loads characterized on an annual basis, may be performed initially to quickly determine the economic viability of the proposed project. Screening analyses using time-aggregated data do not reflect several critical cost influences, however. Seasonal and diurnal variations in electrical and thermal loads, as well as time-of-use utility pricing structures, can have a dramatic impact on the economics. A more accurate economic assessment requires additional detailed data on electrical and thermal demand (e.g., hourly load data), which may not be readily available for the specific facility under study. Recent developments in CHP evaluation tools, however, can generate the needed hourly data through the use of historical data libraries and building simulation. This article utilizes model-generated hourly load data for four potential CHP applications and compares the calculated cost savings of a CHP system when evaluated on a time-aggregated (i.e., annual) basis to the savings when evaluated on an hour-by-hour basis. It is observed that the simple, aggregated analysis forecasts much greater savings (i.e., greater economic viability) than the more detailed hourly analysis. The findings confirm that the simpler tool produces results with a much more optimistic outlook, which, if taken by itself, might lead to erroneous project decisions. The more rigorous approach, being more reflective of actual requirements and conditions, presents a more accurate economic comparison of the alternatives, which, in turn, leads to better decision risk management.

  11. 'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care

    E-Print Network [OSTI]

    Clarke, Angus J; Cooper, David N; Krawczak, Michael; Tyler-Smith, Chris; Wallace, Helen M; Wilkie, Andrew O M; Raymond, Frances L; Chadwick, Ruth; Craddock, Nick; John, Ros; Gallacher, John; Chiano, Mathias

    2012-08-02T23:59:59.000Z

    the system of governance also serves other, more institutional purposes. The prospect of internet-based marketing corporations using access to research data and to electronic health records as an op- portunity to market more products seems both manipu- lative...

  12. High-throughput on-chip in vivo neural regeneration studies usingfemtosecond laser nano-surgery and microfluidics

    E-Print Network [OSTI]

    Samara, Chrysanthi

    In recent years, the advantages of using small invertebrate animals as model systems for human disease have become increasingly apparent and have resulted in three Nobel Prizes in medicine or chemistry during the last six ...

  13. A Micro-aspirator Chip Using Vacuum Expanded Microchannels for High-throughput Mechanical Characterization of Biological Cells

    E-Print Network [OSTI]

    Kim, Woosik

    2011-10-21T23:59:59.000Z

    to ultraviolet and visible light, permeable to gases and only moderately permeable to water [54-55]. The prepolymer of PDMS is commercially available, inexpensive, and easy to 16 prepare. Due to these advantages, PDMS microfluidic systems have applications... and staff for making my time at Texas A&M University a great experience. Finally, thanks to my mother and father for their patience and love and to my supporter for the endless encouragement. vii NOMENCLATURE ?TAS Micro-Total Analysis System PDMS...

  14. A GPU-INSPIRED SOFT PROCESSOR FOR HIGH-THROUGHPUT ACCELERATION Jeffrey Kingyens and J. Gregory Steffan

    E-Print Network [OSTI]

    Toronto, University of

    hardware support for up to 256 concurrent thread contexts. The key new contributions of our architecture and pipeline latency. Through simulation of a system that (i) supports AMD's CTM r5xx GPU ISA [1], and (ii RASC which integrates FPGAs into a blade server platform, and XtremeData and Nallatech that offer FPGA

  15. Cluster Computing: High-Performance, High-Availability, and High-Throughput Processing on a Network of Computers

    E-Print Network [OSTI]

    Buyya, Rajkumar

    Laboratory Dept. of Computer Science and Software Engineering The University of Melbourne, Australia {csyeo, raj}@cs.mu.oz.au 2 Parallel and Distributed Systems Laboratory Department of Computer Science for cluster computing was developed in the 1960s by IBM as an alternative of linking large mainframes

  16. A NOVEL LOW THERMAL BUDGET THIN-FILM POLYSILICON FABRICATION PROCESS FOR LARGE-AREA, HIGH-THROUGHPUT SOLAR CELL PRODUCTION

    SciTech Connect (OSTI)

    Yue Kuo

    2010-08-15T23:59:59.000Z

    A novel thin-film poly-Si fabrication process has been demonstrated. This low thermal budget process transforms the single- and multi-layer amorphous silicon thin films into a poly-Si structure in one simple step over a pulsed rapid thermal annealing process with the enhancement of an ultrathin Ni layer. The complete poly-Si solar cell was fabricated in a short period of time without deteriorating the underneath glass substrate. The unique vertical crystallization process including the mechanism is discussed. Influences of the dopant type and process parameters on crystal structure will be revealed. The poly-Si film structure has been proved using TEM, XRD, Raman, and XPS methods. The poly-Si solar cell structure and the performance have been examined. In principle, the new process is potentially applicable to produce large-area thin-film poly-Si solar cells at a high throughput and low cost. A critical issue in this process is to prevent the excessive dopant diffusion during crystallization. Process parameters and the cell structure have to be optimized to achieve the production goal.

  17. Environmental Measurement While Drilling System for Real-Time Field Screening of Contaminants

    SciTech Connect (OSTI)

    Lockwood, G.J.; Normann, R.A.; Williams, C.V.

    1999-02-22T23:59:59.000Z

    Sampling during environmental drilling is essential to fully characterize the spatial distribution and migration of subsurface contaminants. However, analysis of the samples is expensive and time-consuming: off-site laboratory analysis can take weeks or months. Real-time information on environmental conditions, drill bit location and temperature during drilling is valuable in many environmental restoration operations. This type of information can be used to provide field screening data and improved efficiency of site characterization activities. The Environmental Measurement-While-Drilling (EMWD) System represents an innovative blending of new and existing technology in order to obtain real-time data during drilling. The system consists of two subsystems. The down-hole subsystem (at the drill bit) consists of sensors, a power supply, a signal conditioning and transmitter board, and a radio-frequency (RF) coaxial cable. The up-hole subsystem consists of a battery pack/coil, pickup coil, receiver, and personal computer. The system is compatible with fluid miser drill pipe, a directional drilling technique that uses minimal drilling fluids and generates little to no secondary waste. In EMWD, downhole sensors are located behind the drill bit and linked by a high-speed data transmission system to a computer at the surface. Sandia-developed Windows{trademark}-based software is used for data display and storage. As drilling is conducted, data is collected on the nature and extent of contamination, enabling on-the-spot decisions regarding drilling and sampling strategies. Initially, the downhole sensor consisted of a simple gamma radiation detector, a Geiger-Mueller tube (GMT). The design includes data assurance techniques to increase safety by reducing the probability of giving a safe indication when an unsafe condition exists. The EMWD system has been improved by the integration of a Gamma Ray Spectrometer (GRS) in place of the GMT. The GRS consists of a sodium iodide-thallium activated crystal coupled to a photomultiplier tube (PMT). The output of the PMT goes to a multichannel analyzer (MCA).The MCA data is transmitted to the surface via a signal conditioning and transmitter board similar to that used with the GMT. The EMWD system is described and the results of the GRS field tests and field demonstration are presented.

  18. Development of a semi-automated ZLC system for rapid screening of adsorbents for carbon capture 

    E-Print Network [OSTI]

    Hu, Xiayi

    2012-06-25T23:59:59.000Z

    In this dissertation a novel ZLC setup has been developed as part of a DOE-funded grant in collaboration with UOP, to provide rapid screening of novel adsorbent materials for carbon capture (CC). The key features of the ...

  19. High-Throughput Plasmonic Nanolithography

    E-Print Network [OSTI]

    Pan, Liang

    2010-01-01T23:59:59.000Z

    heating Module..FH Control and Resist Pre-heating Module Inspired by thecontrol and resist pre-heating module using the same laser

  20. High-Throughput Plasmonic Nanolithography

    E-Print Network [OSTI]

    Pan, Liang

    2010-01-01T23:59:59.000Z

    optical near field from a bowtie aperture. Applied PhysicsUtilizing the near- field of bowtie optical nanoantennas.H-shaped, I-shaped and bowtie apertures. Although the

  1. Global health response more accurate with automated influenza...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    will design the automated high-throughput extraction and screening system for a prototype Global Bio Lab-a compact, modular laboratory that can reliably process thousands of...

  2. Engineering task plan for the development of a high pressure water drill system for BY-105 saltwell screen installation

    SciTech Connect (OSTI)

    RITTER, G.A.

    1999-02-24T23:59:59.000Z

    This engineering task plan identifies the activities required for developing an ultra high pressure water drill system for installation of a saltwell screen in Tank BY-105. A water drill system is needed to bore through the hard waste material in this tank because of the addition of Portland cement in the 1960s and/or 1970s. The activities identified in this plan include the design, procurement, and qualification testing of the water drill along with readiness preparations including developing operating procedures, training Operations personnel, and conducting an assessment of readiness.

  3. From screen to structure with a harvestable microfluidic device

    SciTech Connect (OSTI)

    Stojanoff V.; Jakonic, J.; Oren, D.A.; Nagarajan, V.; Navarro Poulsen, J.C.; Adams-Cioaba, M.A.; Bergfors, T. and Sommer, M.O.A.

    2011-06-21T23:59:59.000Z

    Advances in automation have facilitated the widespread adoption of high-throughput vapor-diffusion methods for initial crystallization screening. However, for many proteins, screening thousands of crystallization conditions fails to yield crystals of sufficient quality for structural characterization. Here, the rates of crystal identification for thaumatin, catalase and myoglobin using microfluidic Crystal Former devices and sitting-drop vapour-diffusion plates are compared. It is shown that the Crystal Former results in a greater number of identified initial crystallization conditions compared with vapor diffusion. Furthermore, crystals of thaumatin and lysozyme obtained in the Crystal Former were used directly for structure determination both in situ and upon harvesting and cryocooling. On the basis of these results, a crystallization strategy is proposed that uses multiple methods with distinct kinetic trajectories through the protein phase diagram to increase the output of crystallization pipelines.

  4. Development of a trace explosives detection portal for personnel screening

    SciTech Connect (OSTI)

    Parmeter, J.E.; Linker, K.L.; Rhykerd, C.L. Jr.; Bouchier, F.A.; Hannum, D.W.

    1998-08-01T23:59:59.000Z

    The authors discuss the development, design, and operation of a walk-through trace detection portal designed to screen personnel for explosives. Developed at Sandia National Laboratories (SNL) with primary funding from the Federal Aviation Administration (FAA) and additional support from the Department of Energy office of Safeguards and Security, this portal is intended primarily for use in airport terminals and in other localities where a very high throughput of pedestrian traffic is combined with stringent security requirements. The portal is capable of detecting both vapor and particulate contamination, with the collection of explosive material being based upon the entrainment of that material in air flows over the body of the person being screened. This portal is capable of detecting most types of common high explosives of interest to the FAA. The authors discuss the results of field testing of the portal in the Albuquerque International Airport in September, 1997 and more recent steps towards commercialization of the portal.

  5. Development & Optimization of Materials and Processes for a Cost Effective Photoelectrochemical Hydrogen Production System. Final report

    SciTech Connect (OSTI)

    McFarland, Eric W

    2011-01-17T23:59:59.000Z

    The overall project objective was to apply high throughput experimentation and combinatorial methods together with novel syntheses to discover and optimize efficient, practical, and economically sustainable materials for photoelectrochemical production of bulk hydrogen from water. Automated electrochemical synthesis and photoelectrochemical screening systems were designed and constructed and used to study a variety of new photoelectrocatalytic materials. We evaluated photocatalytic performance in the dark and under illumination with or without applied bias in a high-throughput manner and did detailed evaluation on many materials. Significant attention was given to ?-Fe2O3 based semiconductor materials and thin films with different dopants were synthesized by co-electrodeposition techniques. Approximately 30 dopants including Al, Zn, Cu, Ni, Co, Cr, Mo, Ti, Pt, etc. were investigated. Hematite thin films doped with Al, Ti, Pt, Cr, and Mo exhibited significant improvements in efficiency for photoelectrochemical water splitting compared with undoped hematite. In several cases we collaborated with theorists who used density functional theory to help explain performance trends and suggest new materials. The best materials were investigated in detail by X-ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet-visual spectroscopy (UV-Vis), X-ray photoelectron spectroscopy (XPS). The photoelectrocatalytic performance of the thin films was evaluated and their incident photon

  6. Verifying Distributed Real-time Properties of Embedded Systems via Graph Transformations and Model Checking

    E-Print Network [OSTI]

    Abdelwahed, Sherif

    S properties, such as low latency, low energy consumption, bounded jitter, high reliability, high throughput and data acquisition (SCADA) systems that manage regional power grids. Key un- resolved challenges include

  7. Preliminary Screening

    Broader source: Energy.gov [DOE]

    The first step in assessing renewable energy options is to conduct a preliminary screening to decide which technologies are worth investigating and which can be eliminated immediately. Preliminary...

  8. A screening model to explore planning decisions in automotive manufacturing systems under demand uncertainty

    E-Print Network [OSTI]

    Yang, Yingxia

    2009-01-01T23:59:59.000Z

    Large-scale, complex engineering systems, as for automotive manufacturing, often require significant capital investment and resources for systems configuration. Furthermore, these systems operate in environments that are ...

  9. Screening Analysis for the Environmental Risk Evaluation System Fiscal Year 2011 Report Environmental Effects of Offshore Wind Energy

    SciTech Connect (OSTI)

    Copping, Andrea E.; Hanna, Luke A.

    2011-11-01T23:59:59.000Z

    Potential environmental effects of offshore wind (OSW) energy development are not well understood, and yet regulatory agencies are required to make decisions in spite of substantial uncertainty about environmental impacts and their long-term consequences. An understanding of risks associated with interactions between OSW installations and avian and aquatic receptors, including animals, habitats, and ecosystems, can help define key uncertainties and focus regulatory actions and scientific studies on interactions of most concern. During FY 2011, Pacific Northwest National Laboratory (PNNL) scientists adapted and applied the Environmental Risk Evaluation System (ERES), first developed to examine the effects of marine and hydrokinetic energy devices on aquatic environments, to offshore wind development. PNNL scientists conducted a risk screening analysis on two initial OSW cases: a wind project in Lake Erie and a wind project off the Atlantic coast of the United States near Atlantic City, New Jersey. The screening analysis revealed that top-tier stressors in the two OSW cases were the dynamic effects of the device (e.g., strike), accidents/disasters, and effects of the static physical presence of the device, such as alterations in bottom habitats. Receptor interactions with these stressors at the highest tiers of risk were dominated by threatened and endangered animals. Risk to the physical environment from changes in flow regime also ranked high. Peer review of this process and results will be conducted during FY 2012. The ERES screening analysis provides an assessment of the vulnerability of environmental receptors to stressors associated with OSW installations; a probability analysis is needed to determine specific risk levels to receptors. As more data become available that document effects of offshore wind farms on specific receptors in U.S. coastal and Great Lakes waters, probability analyses will be performed.

  10. Digital I&C systems in nuclear power plants. Risk-screening of environmental stressors and a comparison of hardware unavailability with an existing analog system

    SciTech Connect (OSTI)

    Hassan, M.; Vesely, W.E.

    1998-01-01T23:59:59.000Z

    In this report, we present a screening study to identify environmental stressors for digital instrumentation and control (I&C) systems in a nuclear power plant (NPP) which can be potentially risk-significant, and compare the hardware unavailability of such a system with that of its existing analog counterpart. The stressors evaluated are temperature, humidity, vibration, radiation, electro-magnetic interference (EMI), and smoke. The results of risk-screening for an example plant, subject to some bounding assumptions and based on relative changes in plant risk (core damage frequency impacts of the stressors), indicate that humidity, EMI from lightning, and smoke can be potentially risk-significant. Risk from other sources of EMI could not be evaluated for a lack of data. Risk from temperature appears to be insignificant as that from the assumed levels of vibrations. A comparison of the hardware unavailability of the existing analog Safety Injection Actuation System (SIAS) in the example plant with that of an assumed digital upgrade of the system indicates that system unavailability may be more sensitive to the level of redundancy in elements of the digital system than to the environmental and operational variations involved. The findings of this study can be used to focus activities relating to the regulatory basis for digital I&C upgrades in NPPs, including identification of dominant stressors, data-gathering, equipment qualification, and requirements to limit the effects of environmental stressors. 30 refs., 8 figs., 26 tabs.

  11. Exploring flexible strategies in engineering systems using screening models : applications to offshore petroleum projects

    E-Print Network [OSTI]

    Lin, Jijun, Ph. D. Massachusetts Institute of Technology

    2009-01-01T23:59:59.000Z

    Engineering Systems, such as offshore petroleum exploration and production systems, generally require a significant amount of capital investment under various technical and market uncertainties. Choosing appropriate designs ...

  12. Usability Heuristics and Qualitative Indicators for the Usability Evaluation of Touch Screen Ventilator Systems

    E-Print Network [OSTI]

    Boyer, Edmond

    Ventilator Systems Dinesh Katre1, Ganesh Bhutkar2 , Shekhar Karmarkar3 1 Group Coordinator, Human complexity in the user interface, features and functionalities of ventilator systems can cause medical errors and cost the life of a patient. Therefore, the usability of ventilator systems is most crucial to ensure

  13. System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures

    DOE Patents [OSTI]

    Sundaram, S Kamakshi [Richland, WA; Riley, Brian J [West Richland, WA; Weber, Thomas J [Richland, WA; Sacksteder, Colette A [West Richland, WA; Addleman, R Shane [Benton City, WA

    2011-06-07T23:59:59.000Z

    An ATR-FTIR device and system are described that defect live-cell responses to stimuli and perturbations in real-time. The system and device can monitor perturbations resulting from exposures to various physical, chemical, and biological materials in real-time, as well as those sustained over a long period of time, including those associated with stimuli having unknown modes-of-action (e.g. nanoparticles). The device and system can also be used to identify specific chemical species or substances that profile cellular responses to these perturbations.

  14. Development of FRET-based Technologies for Dynamic and Quantitative Measurement of Protein-protein Interactions and High-throughput Screening of Small Chemical Inhibitors of the SUMO Pathway

    E-Print Network [OSTI]

    Song, Yang

    2011-01-01T23:59:59.000Z

    Figure 9A). The non- linear regression fitted the data0.96 to 0.99). From the non-linear regression, the values ofdescribed above. Both non-linear regression fitted the data

  15. System and method for generating and/or screening potential metal-organic frameworks

    DOE Patents [OSTI]

    Wilmer, Christopher E; Leaf, Michael; Snurr, Randall Q; Farha, Omar K; Hupp, Joseph T

    2014-12-02T23:59:59.000Z

    A system and method for systematically generating potential metal-organic framework (MOFs) structures given an input library of building blocks is provided herein. One or more material properties of the potential MOFs are evaluated using computational simulations. A range of material properties (surface area, pore volume, pore size distribution, powder x-ray diffraction pattern, methane adsorption capability, and the like) can be estimated, and in doing so, illuminate unidentified structure-property relationships that may only have been recognized by taking a global view of MOF structures. In addition to identifying structure-property relationships, this systematic approach to identify the MOFs of interest is used to identify one or more MOFs that may be useful for high pressure methane storage.

  16. A Cell-Based Approach for the Biosynthesis/Screening of Cyclic Peptide Libraries against Bacterial Toxins

    SciTech Connect (OSTI)

    Camarero, J A; Kimura, R; Woo, Y; Cantor, J; Steenblock, E

    2007-10-24T23:59:59.000Z

    Available methods for developing and screening small drug-like molecules able to knockout toxins or pathogenic microorganisms have some limitations. In order to be useful, these new methods must provide high-throughput analysis and identify specific binders in a short period of time. To meet this need, we are developing an approach that uses living cells to generate libraries of small biomolecules, which are then screened inside the cell for activity. Our group is using this new, combined approach to find highly specific ligands capable of disabling anthrax Lethal Factor (LF) as proof of principle. Key to our approach is the development of a method for the biosynthesis of libraries of cyclic peptides, and an efficient screening process that can be carried out inside the cell.

  17. Projection screen having reduced ambient light scattering

    DOE Patents [OSTI]

    Sweatt, William C. (Albuquerque, NM)

    2010-05-11T23:59:59.000Z

    An apparatus and method for improving the contrast between incident projected light and ambient light reflected from a projection screen are described. The efficiency of the projection screen for reflection of the projected light remains high, while permitting the projection screen to be utilized in a brightly lighted room. Light power requirements from the projection system utilized may be reduced.

  18. Wafer screening device and methods for wafer screening

    DOE Patents [OSTI]

    Sopori, Bhushan; Rupnowski, Przemyslaw

    2014-07-15T23:59:59.000Z

    Wafer breakage is a serious problem in the photovoltaic industry because a large fraction of wafers (between 5 and 10%) break during solar cell/module fabrication. The major cause of this excessive wafer breakage is that these wafers have residual microcracks--microcracks that were not completely etched. Additional propensity for breakage is caused by texture etching and incomplete edge grinding. To eliminate the cost of processing the wafers that break, it is best to remove them prior to cell fabrication. Some attempts have been made to develop optical techniques to detect microcracks. Unfortunately, it is very difficult to detect microcracks that are embedded within the roughness/texture of the wafers. Furthermore, even if such detection is successful, it is not straightforward to relate them to wafer breakage. We believe that the best way to isolate the wafers with fatal microcracks is to apply a stress to wafers--a stress that mimics the highest stress during cell/module processing. If a wafer survives this stress, it has a high probability of surviving without breakage during cell/module fabrication. Based on this, we have developed a high throughput, noncontact method for applying a predetermined stress to a wafer. The wafers are carried on a belt through a chamber that illuminates the wafer with an intense light of a predetermined intensity distribution that can be varied by changing the power to the light source. As the wafers move under the light source, each wafer undergoes a dynamic temperature profile that produces a preset elastic stress. If this stress exceeds the wafer strength, the wafer will break. The broken wafers are separated early, eliminating cost of processing into cell/module. We will describe details of the system and show comparison of breakage statistics with the breakage on a production line.

  19. Investigating the Operational Capabilities of Custom and Pedestrian Portal Monitoring Systems for Screening Livestock for Radioactive Contamination

    E-Print Network [OSTI]

    Erchinger, Jennifer

    2013-05-01T23:59:59.000Z

    radionuclide identification capabilities. An array of six sodium iodide detectors was mounted on a panel and field-tested beside a cattle chute and in a walkway. The custom portal, the Bovine Screening Portal (BSP), observed increased count rates (>10?) from a...

  20. Implementation of a DOD ELAP Conforming Quality System at a FUSRAP Site Field Temporary Radiological Screening Laboratory - 13500

    SciTech Connect (OSTI)

    Winters, M.S.; McElheny, G. [Cabrera Services Inc. 473 Silver Lane, East Hartford, CT (United States)] [Cabrera Services Inc. 473 Silver Lane, East Hartford, CT (United States); Houston, L.M.; Masset, M.R.; Spector, H.L. [United States Army Corps of Engineers -1776 Niagara Street, Buffalo, NY (United States)] [United States Army Corps of Engineers -1776 Niagara Street, Buffalo, NY (United States)

    2013-07-01T23:59:59.000Z

    A case study is presented on specific program elements that supported the transition of a temporary field radiological screening lab to an accredited operation capable of meeting client quality objectives for definitive results data. The temporary field lab is located at the Formerly Utilized Sites Remedial Action Program Linde Site in Tonawanda, NY. The site is undergoing remediation under the direction of the United States Army Corps of Engineers - Buffalo District, with Cabrera Services Inc. as the remediation contractor and operator of the on-site lab. Analysis methods employed in the on-site lab include gross counting of alpha and beta particle activity on swipes and air filters and gamma spectroscopy of soils and other solid samples. A discussion of key program elements and lessons learned may help other organizations considering pursuit of accreditation for on-site screening laboratories. (authors)

  1. Unconventional Architectures for High-Throughput Sciences

    SciTech Connect (OSTI)

    Nieplocha, Jarek; Marquez, Andres; Petrini, Fabrizio; Chavarría-Miranda, Daniel

    2007-06-15T23:59:59.000Z

    Science laboratories and sophisticated simulations are producing data of increasing volumes and complexities, and that’s posing significant challenges to current data infrastructures as terabytes to petabytes of data must be processed and analyzed. Traditional computing platforms, originally designed to support model-driven applications, are unable to meet the demands of the data-intensive scientific applications. Pacific Northwest National Laboratory (PNNL) research goes beyond “traditional supercomputing” applications to address emerging problems that need scalable, real-time solutions. The outcome is new unconventional architectures for data-intensive applications specifically designed to process the deluge of scientific data, including FPGAs, multithreaded architectures and IBM's Cell.

  2. High-ThroughputTagging of Arabidopsis Proteins

    E-Print Network [OSTI]

    Citovsky, Vitaly

    ­0124 (N.C., G.D., N.V.R.); and The Arabidopsis Information Resource (S.L., S.Y.R.) and Carnegie Institution of Washington (S.L., D.E., S.Y.R), Stanford, California 94305 We developed a high their chromogenic reac- tion products (Taylor, 1997). The use of antigenic tags, such as the T7 or HA epitopes

  3. High-throughput proteomics : optical approaches.

    SciTech Connect (OSTI)

    Davidson, George S.

    2008-09-01T23:59:59.000Z

    Realistic cell models could greatly accelerate our ability to engineer biochemical pathways and the production of valuable organic products, which would be of great use in the development of biofuels, pharmaceuticals, and the crops for the next green revolution. However, this level of engineering will require a great deal more knowledge about the mechanisms of life than is currently available. In particular, we need to understand the interactome (which proteins interact) as it is situated in the three dimensional geometry of the cell (i.e., a situated interactome), and the regulation/dynamics of these interactions. Methods for optical proteomics have become available that allow the monitoring and even disruption/control of interacting proteins in living cells. Here, a range of these methods is reviewed with respect to their role in elucidating the interactome and the relevant spatial localizations. Development of these technologies and their integration into the core competencies of research organizations can position whole institutions and teams of researchers to lead in both the fundamental science and the engineering applications of cellular biology. That leadership could be particularly important with respect to problems of national urgency centered around security, biofuels, and healthcare.

  4. High Throughput Materials Characterization John M. Gregoire

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm) Harmonicbet WhenHiggs BosonAccurate knowledge of

  5. Reverse Ecology: From Systems to Environments and Back

    E-Print Network [OSTI]

    Borenstein, Elhanan

    Chapter 15 Reverse Ecology: From Systems to Environments and Back Roie Levy and Elhanan Borenstein the environments in which they evolved and are adapted to. Re- verse Ecology--an emerging new frontier's ecology. The Reverse Ecology framework facilitates the translation of high-throughput genomic data

  6. Screening of Hydrocarbon Sources in JET

    SciTech Connect (OSTI)

    J.D. Strachan; W. Fundamenski; M. Charlet; K. Erents; J. Gafert; C. Giroud; M. von Hellermann; G. Matthews; G. McCracken; V. Philipps; J. Spence; M.F. Stamp; K-D. Zastrow; and EFDA-JET Work Programme Collaborators

    2001-06-15T23:59:59.000Z

    Carbon is the principal impurity in the Joint European Torus (JET). Methane screening experiments quantify the ability of the scrape-off layer (SOL)/divertor system to ionize carbon and transport it to the divertor, preventing core plasma contamination. Previous JET publications studied edge-localized-mode-averaged high-confinement mode screening, and separately, evaluated the methodology of low-confinement mode (L-mode) screening measurements. This paper extends the L-mode measurements to include relevant plasma parameter scans and DIVIMP modeling of the L-mode screening.

  7. Screening study for evaluation of the potential for system 80+ to consume excess plutonium - Volume 1. Final report

    SciTech Connect (OSTI)

    Not Available

    1994-04-30T23:59:59.000Z

    As part of the U.S. effort to evaluate technologies offering solutions for the safe disposal or utilization of surplus nuclear materials, the fiscal year 1993 Energy and Water Appropriations legislation provided the Department of Energy (DOE) the necessary funds to conduct multi-phased studies to determine the technical feasibility of using reactor technologies for the triple mission of burning weapons grade plutonium, producing tritium for the existing smaller weapons stockpile, and generating commercial electricity. DOE limited the studies to five advanced reactor designs. Among the technologies selected is the ABB-Combustion Engineering (ABB-CE) System 80+. The DOE study, currently in Phase ID, is proceeding with a more detailed evaluation of the design`s capability for plutonium disposition.

  8. Screening study for evaluation of the potential for system 80+ to consume excess plutonium - Volume 2. Final report

    SciTech Connect (OSTI)

    Not Available

    1994-04-30T23:59:59.000Z

    As part of the U.S. effort to evaluate technologies offering solutions for the safe disposal or utilization of surplus nuclear materials, the fiscal year 1993 Energy and Water Appropriations legislation provided the Department of Energy (DOE) the necessary funds to conduct multi-phased studies to determine the technical feasibility of using reactor technologies for the triple mission of burning weapons grade plutonium, producing tritium for the existing smaller weapons stockpile, and generating commercial electricity. DOE limited the studies to five advanced reactor designs. Among the technologies selected is the ABB-Combustion Engineering (ABB-CE) System 80+. The DOE study, currently in Phase ID, is proceeding with a more detailed evaluation of the design`s capability for plutonium disposition.

  9. Clad Degradation - FEPs Screening Arguments

    SciTech Connect (OSTI)

    E. Siegmann

    2004-03-17T23:59:59.000Z

    The purpose of this report is to document the screening of the cladding degradation features, events, and processes (FEPs) for commercial spent nuclear fuel (CSNF). This report also addresses the effect of some FEPs on both the cladding and the CSNF, DSNF, and HLW waste forms where it was considered appropriate to address the effects on both materials together. This report summarizes the work of others to screen clad degradation FEPs in a manner consistent with, and used in, the Total System Performance Assessment-License Application (TSPA-LA). This document was prepared according to ''Technical Work Plan for Waste Form Degradation Modeling, Testing, and Analyses in Support of LA'' (BSC 2004a [DIRS 167796]).

  10. Bose-Einstein Condensation on Holographic Screens

    E-Print Network [OSTI]

    Mirza, Behrouz; Raissi, Zahra

    2011-01-01T23:59:59.000Z

    We consider a boson gas on holographic screens of the Rindler and Schwartzschild spacetimes. It is shown that the gas on the stretched horizon is in a Bose-Einstein condensed state with the Hawking temperature $T_c=T_H$ if the particle number of the system be equal to the number of quantum bits of spacetime $ N \\simeq {A}/{{\\l_{p}}^{2}}$. A boson gas on a holographic screen $(r>2M)$ with the same number of particles and at Unruh temperature is also in a condensed state. Far from the horizon, the Unruh temperature is much lower than the condensation temperature $(T_c=T_{{Unruh}}+\\sqrt {f(r)} T_{Planck})$. This analysis implies a possible physical model for quantum bits of spacetime on a holographic screen. We propose a unique and physical interpretation for equipartition theorem on holographic screens. Also, we will argue that this gas is a fast scrambler.

  11. Algorithm for Screening Phasor Measurement Unit Data for Power System Events and Categories and Common Characteristics for Events Seen in Phasor Measurement Unit Relative Phase-Angle Differences and Frequency Signals

    SciTech Connect (OSTI)

    Allen, A.; Santoso, S.; Muljadi, E.

    2013-08-01T23:59:59.000Z

    A network of multiple phasor measurement units (PMU) was created, set up, and maintained at the University of Texas at Austin to obtain actual power system measurements for power system analysis. Power system analysis in this report covers a variety of time ranges, such as short- term analysis for power system disturbances and their effects on power system behavior and long- term power system behavior using modal analysis. The first objective of this report is to screen the PMU data for events. The second objective of the report is to identify and describe common characteristics extracted from power system events as measured by PMUs. The numerical characteristics for each category and how these characteristics are used to create selection rules for the algorithm are also described. Trends in PMU data related to different levels and fluctuations in wind power output are also examined.

  12. Ion beam lithography system

    DOE Patents [OSTI]

    Leung, Ka-Ngo

    2005-08-02T23:59:59.000Z

    A maskless plasma-formed ion beam lithography tool provides for patterning of sub-50 nm features on large area flat or curved substrate surfaces. The system is very compact and does not require an accelerator column and electrostatic beam scanning components. The patterns are formed by switching beamlets on or off from a two electrode blanking system with the substrate being scanned mechanically in one dimension. This arrangement can provide a maskless nano-beam lithography tool for economic and high throughput processing.

  13. Conventional Medical Screening Program

    Broader source: Energy.gov [DOE]

    Medical screening is a strategy used to identify diseases or conditions in a select population at an early stage, often before signs and symptoms develop, and to refer individuals with suspicious findings to their personal physician or a specialist for further testing, diagnosis, and treatment. The program is not intended to serve as a substitute for routine medical exams through an individual's personal physician.

  14. Hydropower Potential Screening Study

    E-Print Network [OSTI]

    Hydropower Potential Screening Study Gillian Charles GRAC 5/28/14 #12;Latest Hydropower Potential Study Creating a Buzz 2014 DOE study on undeveloped stream reaches 84.7 GW undeveloped hydropower in undeveloped stream reaches hydropower in the PNW #12;Studies at both National

  15. Preliminary Screening Analysis for the Environmental Risk Evaluation System: Task 2.1.1: Evaluating Effects of Stressors – Fiscal Year 2010 Progress Report: Environmental Effects of Marine and Hydrokinetic Energy

    SciTech Connect (OSTI)

    Anderson, Richard M.; Copping, Andrea E.; Van Cleve, Frances B.

    2010-11-15T23:59:59.000Z

    Possible environmental effects of marine and hydrokinetic (MHK) energy development are not well understood, and yet regulatory agencies are required to make decisions in spite of substantial uncertainty about environmental impacts and their long-term effects. An understanding of risk associated with likely interactions between MHK installations and aquatic receptors, including animals, habitats, and ecosystems, can help reduce the level of uncertainty and focus regulatory actions and scientific studies on interactions of most concern. As a first step in developing the Pacific Northwest National Laboratory (PNNL) Environmental Risk Evaluation System (ERES), PNNL scientists conducted a preliminary risk screening analysis on three initial MHK cases - a tidal project in Puget Sound using Open Hydro turbines, a wave project off the coast of Oregon using Ocean Power Technologies point attenuator buoys, and a riverine current project in the Mississippi River using Free Flow turbines. Through an iterative process, the screening analysis revealed that top-tier stressors in all three cases were the effects of the dynamic physical presence of the device (e.g., strike), accidents, and effects of the static physical presence of the device (e.g., habitat alteration). Receptor interactions with these stressors at the four highest tiers of risk were dominated by marine mammals (cetaceans and pinnipeds) and birds (diving and non-diving); only the riverine case (Free Flow) included different receptors in the third tier (fish) and the fourth tier (benthic invertebrates). Although this screening analysis provides a preliminary analysis of vulnerability of environmental receptors to stressors associated with MHK installations, probability analysis, especially of risk associated with chemical toxicity and accidents such as oil spills or lost gear, will be necessary to further understand high-priority risks. Subject matter expert review of this process and results is required and is planned for the first quarter of FY11. Once expert review is finalized, the screening analysis phase of ERES will be complete.

  16. Cosmic Web and Environmental Dependence of Screening: Vainshtein vs. Chameleon

    E-Print Network [OSTI]

    Bridget Falck; Kazuya Koyama; Gong-bo Zhao

    2015-03-23T23:59:59.000Z

    Theories which modify general relativity to explain the accelerated expansion of the Universe often use screening mechanisms to satisfy constraints on Solar System scales. We investigate the effects of the cosmic web and the local environmental density of dark matter halos on the screening properties of the Vainshtein and chameleon screening mechanisms. We compare the cosmic web morphology of dark matter particles, mass functions of dark matter halos, mass and radial dependence of screening, velocity dispersions and peculiar velocities, and environmental dependence of screening mechanisms in $f(R)$ and nDGP models. Using the ORIGAMI cosmic web identification routine we find that the Vainshtein mechanism depends on the cosmic web morphology of dark matter particles, since these are defined according to the dimensionality of their collapse, while the chameleon mechanism shows no morphology dependence. The chameleon screening of halos and their velocity dispersions depend on halo mass, and small halos and subhalos can be environmentally screened in the chameleon mechanism. On the other hand, the screening of halos in the Vainshtein mechanism does not depend on mass nor environment, and their velocity dispersions are suppressed. The peculiar velocities of halos in the Vainshtein mechanism are enhanced because screened objects can still feel the fifth force generated by external fields, while peculiar velocities of chameleon halos are suppressed when the halo centers are screened.

  17. www.emsl.pnnl.gov New Decade, New Tools, New Science: SyStemS biology

    E-Print Network [OSTI]

    , including high-throughput genomics, transcriptomics, proteomics, and metabolomics analyses as well as high

  18. Scientific Analysis Cover Sheet for Radionuclide Screening

    SciTech Connect (OSTI)

    G. Ragan

    2002-08-09T23:59:59.000Z

    The waste forms under consideration for disposal in the proposed repository at Yucca Mountain contain scores of radionuclides (Attachments V and VI). It would be impractical and highly inefficient to model all of these radionuclides in a total system performance assessment (TSPA). Thus, the purpose of this radionuclide screening analysis is to remove from further consideration (screen out) radionuclides that are unlikely to significantly contribute to radiation dose to the public from the proposed nuclear waste repository at Yucca Mountain. The remaining nuclides (those screened in) are recommended for consideration in TSPA modeling for license application. This analysis also covers radionuclides that are not screened in based on dose, but need to be included in TSPA modeling for other reasons. For example, U.S. Environmental Protection Agency (EPA) and U.S. Nuclear Regulatory Commission (NRC) regulations require consideration of the combined activity of Ra-226 and Ra-228 in groundwater (40 CFR 197.30, 10 CFR 63.331). Also, Cm-245, Pu-241, and U-235 decay indirectly to potentially important radionuclides, and are not identified by the screening analysis as important. The radionuclide screening analysis separately considers two different postclosure time periods: the 10,000-y regulatory period for the proposed repository at Yucca Mountain and the period after 10,000 y up to 1 million y after emplacement. The incremental effect of extending the screening for the regulatory period to 20,000 y is also addressed. Four release scenarios are considered: (1) the nominal scenario, which entails long-term degradation of disposal containers and waste forms, (2) a human-intrusion scenario, (3) an intrusive igneous event, and (4) an eruptive igneous event. Because the first three scenarios require groundwater transport, they are called groundwater scenarios below. The screening analysis considers the following waste forms: spent boiling water reactor (BWR) fuel, spent pressurized water reactor (PWR) fuel, U.S. Department of Energy (DOE) spent nuclear fuel (DSNF), and high-level waste (HLW). Average and outlying (high burnup, high initial enrichment, low age, or otherwise exceptional) forms of each waste-form type are considered. This analysis has been prepared in accordance with a technical work plan (BSC 2002c). In a review of Revision 00 of this radionuclide screening analysis, the NRC found that ''processes that affect transport in the biosphere, such as uptake by plants and bioaccumulation are not accounted for'' and that ''the direct exposure pathway is not accounted for'' (Beckman 2001, Section 5.3.2.1). The NRC also found that the solubility and sorption classes were too broadly defined, noting, for example, that Se is in the same solubility and sorptivity groups as Np and U, yet is ''more soluble than Np and U by several orders of magnitude'' (Beckman 2001, Section 5.3.2.1). This revision seeks to build upon the strengths of the earlier screening method while responding to the specific concerns raised by the NRC and other reviewers. In place of simple inhalation and ingestion dose conversion factors, the revised radionuclide screening uses screening factors that also take into account soil accumulation, uptake by plants, exposure to contaminated ground, and other features of the biosphere that were neglected in the previous screening. Whereas the previous screening analysis allowed only two solubility classes (soluble and insoluble), the revised screening introduces an intermediate solubility class to better segregate the radionuclides into transport groups.

  19. DISPLAY SCREEN EQUIPMENT REGULATIONS 1992

    E-Print Network [OSTI]

    , charts or computer-generated graphics are included. Screens whose main use is to show television or film the standards required by the Regulations. 4 RISKS FROM USING DISPLAY SCREENS The principal risk associated when

  20. Cosmic Web and Environmental Dependence of Screening: Vainshtein vs. Chameleon

    E-Print Network [OSTI]

    Falck, Bridget; Zhao, Gong-bo

    2015-01-01T23:59:59.000Z

    Theories which modify general relativity to explain the accelerated expansion of the Universe often use screening mechanisms to satisfy constraints on Solar System scales. We investigate the effects of the cosmic web and the local environmental density of dark matter halos on the screening properties of the Vainshtein and chameleon screening mechanisms. We compare the cosmic web morphology of dark matter particles, mass functions of dark matter halos, mass and radial dependence of screening, velocity dispersions and peculiar velocities, and environmental dependence of screening mechanisms in $f(R)$ and nDGP models. Using the ORIGAMI cosmic web identification routine we find that the Vainshtein mechanism depends on the cosmic web morphology of dark matter particles, since these are defined according to the dimensionality of their collapse, while the chameleon mechanism shows no morphology dependence. The chameleon screening of halos and their velocity dispersions depend on halo mass, and small halos and subhal...

  1. Page 1 of 9 Full Screen

    E-Print Network [OSTI]

    Levene, Mark

    Evolution of Database Systems Graph-Based Relational Object-Relational 1960's-1970's 1980's-1990's 1990's-Oriented programming language with a DBMS 3 One approach is to implement on top of a relational DBMS. · Object #12;Home Page Title Page Page 5 of 9 Go Back Full Screen Close Quit Object-Relational Evolution

  2. Screening Tool for Desiccant Dehumidification Applications

    E-Print Network [OSTI]

    Czachorski, M.; Worek, W. M.

    1998-01-01T23:59:59.000Z

    A state-of-the-art software tool that calculates the benefits of desiccant-based air-treatment equipment is described. The software, a Desiccant Systems Application Screening Tool, is written in the WindowsTM environment to promote user...

  3. Can infrared gravitons screen $?$?

    E-Print Network [OSTI]

    Jaume Garriga; Takahiro Tanaka

    2007-09-04T23:59:59.000Z

    It has been suggested that infrared gravitons in de Sitter space may lead to a secular screening of the effective cosmological constant. This seems to clash with the naive expectation that the curvature scalar should stay constant due to the Heisenberg equation of motion. Here, we show that the tadpole correction to the local expansion rate, which has been used in earlier analyses as an indicator of a decaying effective $\\Lambda$, is not gauge invariant. On the other hand, we construct a gauge invariant operator which measures the renormalized curvature scalar smeared over an arbitrary window function, and we find that there is no secular screening of this quantity (to any given order in perturbation theory).

  4. Dynamic Screening and Thermonuclear Reaction Rates

    E-Print Network [OSTI]

    Andrei V. Gruzinov

    1997-02-06T23:59:59.000Z

    We show that there are no dynamic screening corrections to the Salpeter's enhancement factor in the weak-screening limit.

  5. Technology support for initiation of high-throughput processing of thin-film CdTe PV modules. Phase 3 final technical report, 14 March 1997--1 April 1998

    SciTech Connect (OSTI)

    Powell, R.C.; Dorer, G.L.; Jayamaha, U.; Hanak, J.J. [Solar Cells, Inc., Toledo, OH (United States)

    1998-09-01T23:59:59.000Z

    Thin-film PV devices based on cadmium telluride have been identified as one of the candidates for high-performance, low-cost source of renewable electrical energy. Roadblocks to their becoming a part of the booming PV market growth have been a low rate of production and high manufacturing cost caused by several rate-limiting process steps. Solar Cells Inc. has focused on the development of manufacturing processes that will lead to high volume and low-cost manufacturing of solar cells and on increasing the performance of the present product. The process research in Phase 3 was concentrated on further refinement of a newly developed vapor transport deposition (VTD) process and its implementation into the manufacturing line. This development included subsystems for glass substrate transport, continuous feed of source materials, generation of source vapors, and uniform deposition of the semiconductor layers. As a result of this R and D effort, the VTD process has now achieved a status in which linear coating speeds in excess of 8 ft/min have been achieved for the semiconductor, equal to about two modules per minute, or 144 kW per 24 hour day. The process has been implemented in a production line, which is capable of round-the-clock continuous production of coated substrates 120 cm x 60 cm in size at a rate of 1 module every four minutes, equal to 18 kW/day. Currently the system cycle time is limited by the rate of glass introduction into the system and glass heating, but not by the rate of the semiconductor deposition. A new SCI record efficiency of 14.1% has been achieved for the cells.

  6. Electron Screening and Alpha-Decay

    E-Print Network [OSTI]

    Agatino Musumarra

    2010-10-21T23:59:59.000Z

    The interplay between nuclear and electromagnetic forces in astrophysical relevant reactions at very low energies is nowadays one of the major subjects of investigation in nuclear astrophysics. Puzzling results concerning the role of Electron Screening (ES) on cross sections of reactions involving light nuclei at low energy open a Pandora pot and many new questions rise on the limits and reliability of the present interpretation of the screening enhancement factor. In the present paper we discuss the simplest physical case where the ES plays an important role in order to have unambiguous determination of ES energy in a clear theoretical scenario. This is the case of alpha-decay of heavy mass nuclei. We deduce the correct sudden and adiabatic limit for such a system including the important relativistic corrections. Then we demonstrate rigorously how in this case the calculation of the sudden and the adiabatic limits leads to the same result. In order to get this result we use the Hellmann-Feynman theorem. After computing the electron screening energy for some systems we discuss the strong modifications of alpha-decay systematic due to electron screening. We conclude proposing a measurement of alpha-decay lifetime of bare nuclei in order to directly deduce ES Energy for heavy nuclei laying in the mass region around 210-240 u.

  7. Updating Technical Screens for PV Interconnection: Preprint

    SciTech Connect (OSTI)

    Coddington, M.; Ellis, A.; Lynn, K.; Razon, A.; Key, T.; Kroposki, B.; Mather, B.; Hill, R.; Nicole, K.; Smith, J.

    2012-08-01T23:59:59.000Z

    Solar photovoltaics (PV) is the dominant type of distributed generation (DG) technology interconnected to electric distribution systems in the United States, and deployment of PV systems continues to increase rapidly. Considering the rapid growth and widespread deployment of PV systems in United States electric distribution grids, it is important that interconnection procedures be as streamlined as possible to avoid unnecessary interconnection studies, costs, and delays. Because many PV interconnection applications involve high penetration scenarios, the process needs to allow for a sufficiently rigorous technical evaluation to identify and address possible system impacts. Existing interconnection procedures are designed to balance the need for efficiency and technical rigor for all DG. However, there is an implicit expectation that those procedures will be updated over time in order to remain relevant with respect to evolving standards, technology, and practical experience. Modifications to interconnection screens and procedures must focus on maintaining or improving safety and reliability, as well as accurately allocating costs and improving expediency of the interconnection process. This paper evaluates the origins and usefulness of the capacity penetration screen, offers potential short-term solutions which could effectively allow fast-track interconnection to many PV system applications, and considers longer-term solutions for increasing PV deployment levels in a safe and reliable manner while reducing or eliminating the emphasis on the penetration screen.

  8. Screening Analysis for the Environmental Risk Evaluation System Task 2.1.1.2: Evaluating Effects of Stressors Fiscal Year 2011 Progress Report - Environmental Effects of Marine and Hydrokinetic Energy

    SciTech Connect (OSTI)

    Copping, Andrea E.; Blake, Kara M.; Anderson, Richard M.; Zdanski, Laura C.; Gill, Gary A.; Ward, Jeffrey A.

    2011-09-01T23:59:59.000Z

    Potential environmental effects of marine and hydrokinetic (MHK) energy development are not well understood, and yet regulatory agencies are required to make decisions in spite of substantial uncertainty about environmental impacts and their long-term consequences. An understanding of risks associated with interactions between MHK installations and aquatic receptors, including animals, habitats, and ecosystems, can help define key uncertainties and focus regulatory actions and scientific studies on interactions of most concern. As a first step in developing the Pacific Northwest National Laboratory (PNNL) Environmental Risk Evaluation System (ERES), PNNL scientists conducted a preliminary risk screening analysis on three initial MHK cases. During FY 2011, two additional cases were added: a tidal project in the Gulf of Maine using Ocean Renewable Power Company TidGenTM turbines and a wave project planned for the coast of Oregon using Aquamarine Oyster surge devices. Through an iterative process, the screening analysis revealed that top-tier stressors in the two FY 2011 cases were the dynamic effects of the device (e.g., strike), accidents/disasters, and effects of the static physical presence of the device (e.g., habitat alteration). Receptor interactions with these stressors at the highest tiers of risk were dominated by threatened and endangered animals. Risk to the physical environment from changes in flow regime also ranked high. Peer review of this process and results will be conducted in early FY 2012. The ERES screening analysis provides an analysis of vulnerability of environmental receptors to stressors associated with MHK installations, probability analysis is needed to determine specific risk levels to receptors. “Risk” has two components: (1) The likelihood, or “probability”, of the occurrence of a given interaction or event, and (2) the potential “consequence” if that interaction or event were to occur. During FY 2011, the ERES screening analysis focused primarily on the second component of risk, “consequence”, with focused probability analysis for interactions where data was sufficient for probability modeling. Consequence analysis provides an assessment of vulnerability of environmental receptors to stressors associated with MHK installations. Probability analysis is needed to determine specific risk levels to receptors and requires significant data inputs to drive risk models. During FY 2011, two stressor-receptor interactions were examined for the probability of occurrence. The two interactions (spill probability due to an encounter between a surface vessel and an MHK device; and toxicity from anti-biofouling paints on MHK devices) were seen to present relatively low risks to marine and freshwater receptors of greatest concern in siting and permitting MHK devices. A third probability analysis was scoped and initial steps taken to understand the risk of encounter between marine animals and rotating turbine blades. This analysis will be completed in FY 2012.

  9. Fuel assembly debris screen

    SciTech Connect (OSTI)

    Yates, J.; Ewing, R.H.; Patterson, J.F.

    1991-07-09T23:59:59.000Z

    This patent describes a debris screen for a fuel assembly for a reactor to which coolant fluid is supplied. It comprises a substantially planar plate member of material impervious to fluid having an array of coolant openings extending through the plate member dimensioned to trap at least a portion of debris particles carried by the coolant; and a skirt member enclosing the periphery of the plate member; each the coolant flow opening having a coolant entry region at a lower surface of the plate member, a coolant exit region at an upper surface of the plate member and a coolant flow path extending between the entry and exit regions, the flow path including an intermediate segment laterally offset from the entry and exit regions to cause coolant to change direction of flow in the intermediate segment and thereby prevent at least a portion of the debris particles from passing through the plate member.

  10. Electron screening in nickel

    SciTech Connect (OSTI)

    Gajevic, Jelena; Lipoglavsek, Matej; Petrovic, Toni; Pelicon, Primoz [Jozef Stefan Institute, Jamova cesta 39, Ljubljana (Slovenia); Jozef Stefan Institute, Jamova cesta 39, Ljubljana (Slovenia) and Cosylab d.d, Teslova ulica 30, Ljubljana (Slovenia); Jozef Stefan Institute, Jamova cesta 39, Ljubljana (Slovenia)

    2012-11-20T23:59:59.000Z

    In order to further investigate electron screening phenomenon we studied proton induced nuclear reactions over an energy range from 1.35 to 3.08 MeV for different environments: Ni metal and NiO insulator. The measurements were based on observation of the {gamma}-ray yields of {sup 59,61,63,64,65}Cu and {sup 58,60,62}Ni. Also, we have studied the decay of {sup 61}Cu produced in the reaction {sup 60}Ni(p,{gamma}), in order to find a possible decay rate perturbation by atomic electrons and found a small difference in half-life for metallic compared to oxide environment, respectively. The present results clearly show that the metallic environment affects the fusion reactions at low energy and that it might also affect the decay rate.

  11. High-throughput comparison of gene fitness among related bacteria

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    licenses/by/2.0), which permits unrestricted use,Mutations in this gene permit second site mutations in hnsIt is known that rpoS mutants permit mutations in hns in

  12. Microchip Technology for High-Throughput Cancer Pathology

    E-Print Network [OSTI]

    Duberow, Jr, David Paul

    2009-01-01T23:59:59.000Z

    was designed using riboflavin as the photoinitiator. Allwith 6 ”L of 0.1% (w/v) riboflavin (Sigma) and 1.25 ”L 100%

  13. Optical Multiplexing for High-Throughput Spectroscopic Analysis.

    E-Print Network [OSTI]

    Ahmed, Saadiah

    2012-05-03T23:59:59.000Z

    in optical biosensor testing as it provides greater throughput and scalability while being an economical and compact solution. v NOMENCLATURE MFPF Multi Frequency Phase Fluorometer MUX Multiplexer LED Light Emitting Diode DIO Digital Input... oxidase in hybrid silicate microsphere that is coated with nanofilm and reference dye (RITC) (Fig. 1) [2]. The phosphorescent dye is excited by a green light from a LED (light emitting diode) to emit luminescence, the intensity of which is dependent...

  14. High throughput analysis of samples in flowing liquid

    DOE Patents [OSTI]

    Ambrose, W. Patrick (Los Alamos, NM); Grace, W. Kevin (Los Alamos, NM); Goodwin, Peter M. (Los Alamos, NM); Jett, James H. (Los Alamos, NM); Orden, Alan Van (Fort Collins, CO); Keller, Richard A. (White Rock, NM)

    2001-01-01T23:59:59.000Z

    Apparatus and method enable imaging multiple fluorescent sample particles in a single flow channel. A flow channel defines a flow direction for samples in a flow stream and has a viewing plane perpendicular to the flow direction. A laser beam is formed as a ribbon having a width effective to cover the viewing plane. Imaging optics are arranged to view the viewing plane to form an image of the fluorescent sample particles in the flow stream, and a camera records the image formed by the imaging optics.

  15. Potential of High-Throughput Experimentation with Ammonia Borane...

    Broader source: Energy.gov (indexed) [DOE]

    and theory - Materials Discovery DOE BES Hydrogen Fuel Initiative * Structure and dynamics (Neutron and NMR) - Experimental and computational studies of di- hydrogen bonding...

  16. Integrated microbioreactor arrays for high-throughput experimentation

    E-Print Network [OSTI]

    Lee, Harry, 1976-

    2006-01-01T23:59:59.000Z

    Bioprocesses with microbial cells play an important role in producing biopharmaceuticals such as human insulin and human growth hormone, and other products such as amino acids and biopolymers. Because bioprocesses involve ...

  17. High-throughput Synthesis and Metrology of Graphene Materials

    E-Print Network [OSTI]

    Ghazinejad, Maziar Ghazinejad

    2012-01-01T23:59:59.000Z

    and large-area graphene plane as a floor. Preparation ofgraphene was dried and prepared for dye coating. Dye Preparation and

  18. Technology Offer High-throughput Algorithm for Automated

    E-Print Network [OSTI]

    reliability enables the same LC-MS analyses with less human resources as manual correction is not necessary Chemical industry: identification and quantitation of chemical composition of various analytes, e.g. oils

  19. Optical Multiplexing for High-Throughput Spectroscopic Analysis. 

    E-Print Network [OSTI]

    Ahmed, Saadiah

    2012-05-03T23:59:59.000Z

    Implantable optical biosensors are being developed as aids for medical monitoring. Such optical biosensors are analyzed for performance in dynamic sensor testing environment. Multi-Frequency Phase Fluorometer (MFPF) is a key measuring device...

  20. High-throughput comparison of gene fitness among related bacteria

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    having a sum of the two percentile ranks less than 30% (less than the 15 th percentile). Additional files Additionala threshold of the 15 th percentile for “highly selected”

  1. Statistical Algorithms for High-throughput Biological Data /

    E-Print Network [OSTI]

    Jeong, Kyowon

    2013-01-01T23:59:59.000Z

    Nat Genet, Jun 2012. [LHW + 09] Heng Li, Bob Handsaker, Alec25(16):2078–2079, [Li11] Heng Li. Tabix: fast retrieval ofYang, Chun-Qing Song, Le-Heng Wang, Chao Liu, Yan Fu, Zuo-

  2. Towards Experimental Annotation of Genes by High Throughput Sequencing

    SciTech Connect (OSTI)

    Bradbury, Andrew [Los Alamos National Laboratory

    2010-06-03T23:59:59.000Z

    Andrew Bradbury of Los Alamos National Laboratory discusses turning annotation into a sequencing pipeline on June 3, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM

  3. Operational streamlining in a high-throughput genome sequencing center

    E-Print Network [OSTI]

    Person, Kerry P. (Kerry Patrick)

    2006-01-01T23:59:59.000Z

    Advances in medicine rely on accurate data that is rapidly provided. It is therefore critical for the Genome Sequencing platform of the Broad Institute of MIT and Harvard to continually strive to reduce cost, improve ...

  4. Methods and devices for high-throughput dielectrophoretic concentration

    DOE Patents [OSTI]

    Simmons, Blake A. (San Francisco, CA); Cummings, Eric B. (Livermore, CA); Fiechtner, Gregory J. (Germantown, MD); Fintschenko, Yolanda (Livermore, CA); McGraw, Gregory J. (Ann Arbor, MI); Salmi, Allen (Escalon, CA)

    2010-02-23T23:59:59.000Z

    Disclosed herein are methods and devices for assaying and concentrating analytes in a fluid sample using dielectrophoresis. As disclosed, the methods and devices utilize substrates having a plurality of pores through which analytes can be selectively prevented from passing, or inhibited, on application of an appropriate electric field waveform. The pores of the substrate produce nonuniform electric field having local extrema located near the pores. These nonuniform fields drive dielectrophoresis, which produces the inhibition. Arrangements of electrodes and porous substrates support continuous, bulk, multi-dimensional, and staged selective concentration.

  5. Targeted Tandem Mass Spectrometry for High-Throughput Comparative...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    states. Herein, we report on a targeted LC-MSMS capability realized with a 7 Tesla Fourier transform ion cyclotron resonance (FTICR) mass spectrometer equipped with a...

  6. High-Throughput Transfer Imprinting for Organic Semiconductors

    E-Print Network [OSTI]

    Choo, Gihoon

    2013-08-06T23:59:59.000Z

    semiconductors because heat and pressure used in thermal nanoimprint do not damage functional materials. However, issues such as residual layer removal and mold contamination still limit the application of nanoimprint for organic semiconductor patterning...

  7. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    described here, which the research team believes will help usher in the next phase of genomics research. The high flux, brilliance, and focus of the x rays from ALS Beamline 12.3.1...

  8. Microchip Technology for High-Throughput Cancer Pathology

    E-Print Network [OSTI]

    Duberow, Jr, David Paul

    2009-01-01T23:59:59.000Z

    S. , and Marra, M. Resuspension of DNA Sequencing Reactionstability. (A) Sample resuspension in low-concentrationand used as the sole resuspension buffer following sample

  9. High-throughput Synthesis and Metrology of Graphene Materials

    E-Print Network [OSTI]

    Ghazinejad, Maziar Ghazinejad

    2012-01-01T23:59:59.000Z

    24 2.5 Demonstration of PGN based Supercapacitor2-11 (a) CV curves of supercapacitor based on as-grown PGNFigure 2-12 CV curves of supercapacitor based on HNO3 acid

  10. High-Throughput Transfer Imprinting for Organic Semiconductors 

    E-Print Network [OSTI]

    Choo, Gihoon

    2013-08-06T23:59:59.000Z

    . In this work, nanoimprint-based transfer imprinting of organic semiconductor is studied. In the same time the suggested technique is simulated with COMSOL multi-physics simulator to understand its mechanism. This transfer printing technique utilize thermal...

  11. Algorithms for Next-Generation High-Throughput Sequencing Technologies

    E-Print Network [OSTI]

    Kao, Wei-Chun

    2011-01-01T23:59:59.000Z

    parameters for 4 different tiles of the 76- cycle PhiX174scores at error tolerance . . . . 2.9 Tile-specific errorsection). Normalizing by the tile-wide average c t is to

  12. High-Throughput Analytical Model to Evaluate Materials for Temperature

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem NotEnergy,ARMFormsGasReleaseSpeechesHallNot Logged3 HanfordHarry|High-PoweredSwing

  13. High-Throughput Characterization of Porous Materials Using Graphics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem NotEnergy,ARMFormsGasReleaseSpeechesHallNot Logged3

  14. High-Throughput Dry Processes for Large-Area Devices

    SciTech Connect (OSTI)

    BUSS,RICHARD J.; HEBNER,GREGORY A.; RUBY,DOUGLAS S.; YANG,PIN

    1999-11-01T23:59:59.000Z

    In October 1996, an interdisciplinary team began a three-year LDRD project to study the plasma processes of reactive ion etching and plasma-enhanced chemical vapor deposition on large-area silicon devices. The goal was to develop numerical models that could be used in a variety of applications for surface cleaning, selective etching, and thin-film deposition. Silicon solar cells were chosen as the experimental vehicle for this project because an innovative device design was identified that would benefit from immediate performance improvement using a combination of plasma etching and deposition processes. This report presents a summary of the technical accomplishments and conclusions of the team.

  15. High Throughput Analysis of Breast Cancer Specimens on the Grid

    E-Print Network [OSTI]

    cancer accounts for about 30% of all cancers and 15% of all cancer deaths in women in the United States in the United States. Women living in North America have the highest rate of breast cancer in the world [1]. In spite of the increase in the incidence of the disease, the death rates of breast cancer continue

  16. Potential of High-Throughput Experimentation with Ammonia Borane Solid

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin of Contamination in235-1Department of60 DATE:AnnualDepartment ofPotentialYield

  17. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 toAdvances WindRobust,

  18. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 toAdvances WindRobust,Robust,

  19. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 toAdvances WindRobust,Robust,Robust,

  20. Medical Screening Protocol for the Former Worker Medical Screening...

    Broader source: Energy.gov (indexed) [DOE]

    with B-reading Spirometry Physical examination Up to every 3 years Lung cancer Low-dose chest CT scan, where offered 1 Re-screening offered at 3 or 6 months for...

  1. Protein Dynamics Hit the Big Screen

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Protein Dynamics Hit the Big Screen Protein Dynamics Hit the Big Screen Now playing at a supercomputer near you: proteins in action June 29, 2005 Contact: Dan Krotz,...

  2. Optimal Screening for Preclinical Diseases

    E-Print Network [OSTI]

    Li, Ang

    2014-05-19T23:59:59.000Z

    for our model, and that it can be quickly found by any greedy-search algorithm. We further conduct numerical experimentations by which we identify sensitive model inputs. We lastly apply our model to breast cancer screening using practical information...

  3. Objective: Determine the energy use of two greenhouse insulation technologies (a bubble insulation system and an energy/shade screen) retrofitted into plastic covered greenhouses, and compare the

    E-Print Network [OSTI]

    Vermont, University of

    Objective: Determine the energy use of two greenhouse insulation technologies (a bubble insulation structures. 1. Unimproved standard double-layer poly inflated greenhouse (control) 2. Bubble insulation is around 1-2, compared to an estimated 30 for the bubble system. What did we learn? The bubble insulation

  4. Rare earth phosphors and phosphor screens

    DOE Patents [OSTI]

    Buchanan, Robert A. (Palo Alto, CA); Maple, T. Grant (Sunnyvale, CA); Sklensky, Alden F. (Sunnyvale, CA)

    1981-01-01T23:59:59.000Z

    This invention relates to rare earth phosphor screens for converting image carrying incident radiation to image carrying visible or near-visible radiation and to the rare earth phosphor materials utilized in such screens. The invention further relates to methods for converting image carrying charged particles to image carrying radiation principally in the blue and near-ultraviolet region of the spectrum and to stabilized rare earth phosphors characterized by having a continuous surface layer of the phosphors of the invention. More particularly, the phosphors of the invention are oxychlorides and oxybromides of yttrium, lanthanum and gadolinium activated with trivalent cerium and the conversion screens are of the type illustratively including x-ray conversion screens, image amplifier tube screens, neutron imaging screens, cathode ray tube screens, high energy gamma ray screens, scintillation detector screens and screens for real-time translation of image carrying high energy radiation to image carrying visible or near-visible radiation.

  5. Screening of quark-monopole in N=4 plasma

    E-Print Network [OSTI]

    Wei-shui Xu; Ding-fang Zeng

    2014-12-11T23:59:59.000Z

    We study a quark-monopole bound system moving in N=4 SYM plasma with a constant velocity by the AdS/CFT correspondence. The screening length of this system is calculated, and is smaller than that of the quark-antiquark bound state.

  6. Brighter Screens for Nondestructive Digital X-ray Radiography

    SciTech Connect (OSTI)

    Miller, Jr., A. C.; Bell, Z. W.; Carpenter, D. A.

    2003-09-15T23:59:59.000Z

    Fine resolution, bright X-ray screens are needed for digital radiography and material characterization at the Y-12 National Security Complex (Y-12). Current technology is simply not adequate for transferring high-energy X-ray images to visible light for demanding digital applications. Low energy radiography and especially emerging tomographic technologies are severely hampered for Y-12 nondestructive evaluation (NDE) applications by dim screens with poor resolution. Also, the development of more advanced materials characterization techniques, such as electron backscatter diffraction (EBSD), is driven by a design agency desire for tighter specifications and more uniform materials. Brighter screens would allow us to probe materials on a finer scale, leading to a better understanding of material behavior. A number of X-ray screen materials were studied that would be suitable for direct replacement in existing digital imaging systems. Spectroscopic evaluations were first made for a several candidates and indicated that lutetium orthosilicate (LSO) would be a promising candidate for MeV images. A relative comparison of brightness at various energies was then completed which showed that cesium iodide (CsI) could increase brightness by over an order of magnitude. Since image quality is also important for better screens, the resolving capabilities of candidate materials were measured. Resolution measurements were completed at X-ray peak energies up to 420KeV with magnified optical imaging systems, and indicated that LSO and Industrial Quality Incorporated glass (IQI) exhibited higher resolution than the CsI screen. The results give a choice of materials that can be tailored to the particular test under consideration. If high-speed images are necessary and some resolution can be sacrificed, the CsI screen will be a good choice. The screen can be replaced by an IQI or LSO unit if higher resolution is needed later, for instance to focus in on a region of interest. A number of significant findings were obtained from this study. Most important of the findings was that materials are commercially available that are much brighter than screens currently in use. This finding meets the original objective of the project. Two objectives of the study; however, were not met. We hoped to evaluate a 'quantum dot' (nanometer-sized particles of semiconductor material) wavelength conversion screen, but the manufacturer ceased production of the screen shortly before the project was started. The dot screen could be efficient in converting ultraviolet light to visible light which would have proved important for utilizing a Cherenkov screen. Since this was a very new, cutting-edge technology, an alternative supplier was not found during the study. Also, high-energy testing of a Cherenkov light screen was not performed due to difficulties in obtaining appropriate approvals for locating test equipment in the high-energy X-ray vault at Y-12. The test is still important, and is being pursued through follow-on funding sources. Although many film shots will be eliminated by the availability of high quality digital images, the largest potential gains result from the availability of clearer images that show fine detail in the parts under analysis. Digital radiographic data also offers the possibility of easily sharing data with other sites. This could prove invaluable when critical material, placement, assembly, or quality issues are pressing. Also, increased throughput in the NDE facility allows statistically significant numbers of units to be analyzed. Digital technologies may in fact be needed just to meet minimum requirements of future demands. Increased brightness screens allow for such innovations as 3-D tomographic images to be acquired in a reasonable time. Much of the skill required to interpret 'flattened' X-ray images is not needed to maneuver around the reconstructed tomogram. This study showed that several commercially available materials are much brighter than screens currently in use. The study also showed that materials othe

  7. Control System Design for Automatic Cavity Tuning Machines

    SciTech Connect (OSTI)

    Carcagno, R.; Khabiboulline, T.; Kotelnikov, S.; Makulski, A.; Nehring, R.; Nogiec, J.; Ross, M.; Schappert, W.; /Fermilab; Goessel, A.; Iversen, J.; Klinke, D.; /DESY

    2009-05-01T23:59:59.000Z

    A series of four automatic tuning machines for 9-cell TESLA-type cavities are being developed and fabricated in a collaborative effort among DESY, FNAL, and KEK. These machines are intended to support high-throughput cavity fabrication for construction of large SRF-based accelerator projects. Two of these machines will be delivered to cavity vendors for the tuning of XFEL cavities. The control system for these machines must support a high level of automation adequate for industrial use by non-experts operators. This paper describes the control system hardware and software design for these machines.

  8. Walla Walla River Basin Fish Screens Evaluations, 2006 Annual Report.

    SciTech Connect (OSTI)

    Chamness, Mickie; Abernethy, Scott; Tunnicliffe, Cherylyn [Pacific Northwest National Laboratory

    2007-01-01T23:59:59.000Z

    Pacific Northwest National Laboratory evaluated Gardena Farms, Little Walla Walla, and Garden City/Lowden II Phase II fish screen facilities and provided underwater videography beneath a leaking rubber dam in the Walla Walla River basin in 2006. Evaluations of the fish screen facilities took place in early May 2006, when juvenile salmonids are generally outmigrating. At the Gardena Farms site, extended high river levels caused accumulations of debris and sediment in the forebay. This debris covered parts of the bottom drum seals, which could lead to early deterioration of the seals and drum screen. Approach velocities were excessive at the upstream corners of most of the drums, leading to 14% of the total approach velocities exceeding 0.4 feet per second (ft/s). Consequently, the approach velocities did not meet National Marine Fisheries Service (NMFS) design criteria guidelines for juvenile fish screens. The Little Walla Walla site was found to be in good condition, with all approach, sweep, and bypass velocities within NMFS criteria. Sediment buildup was minor and did not affect the effectiveness of the screens. At Garden City/Lowden II, 94% of approach velocities met NMFS criteria of 0.4 ft/s at any time. Sweep velocities increased toward the fish ladder. The air-burst mechanism appears to keep large debris off the screens, although it does not prevent algae and periphyton from growing on the screen face, especially near the bottom of the screens. In August 2006, the Gardena Farm Irrigation District personnel requested that we look for a leak beneath the inflatable rubber dam at the Garden City/Lowden II site that was preventing water movement through the fish ladder. Using our underwater video equipment, we were able to find a gap in the sheet piling beneath the dam. Erosion of the riverbed was occurring around this gap, allowing water and cobbles to move beneath the dam. The construction engineers and irrigation district staff were able to use the video footage to resolve the problem within a couple weeks. We had hoped to also evaluate the effectiveness of modifications to louvers behind the Nursery Bridge screens when flows were higher than 350 cubic feet per second, (cfs) but were unable to do so. Based on the one measurement made in early 2006 after the modified louvers were set, it appears the modified louvers may help reduce approach velocities. The auxiliary supply water system gates also control water through the screens. Evaluating the effect of different combinations of gate and louver positions on approach velocities through the screens may help identify optimum settings for both at different river discharges.

  9. Chemical compatibility screening test results

    SciTech Connect (OSTI)

    Nigrey, P.J.; Dickens, T.G.

    1997-12-01T23:59:59.000Z

    A program for evaluating packaging components that may be used in transporting mixed-waste forms has been developed and the first phase has been completed. This effort involved the screening of ten plastic materials in four simulant mixed-waste types. These plastics were butadiene-acrylonitrile copolymer rubber, cross-linked polyethylene (XLPE), epichlorohydrin rubber, ethylene-propylene rubber (EPDM), fluorocarbon (Viton or Kel-F), polytetrafluoroethylene, high-density polyethylene (HDPE), isobutylene-isoprene copolymer rubber (butyl), polypropylene, and styrene-butadiene rubber (SBR). The selected simulant mixed wastes were (1) an aqueous alkaline mixture of sodium nitrate and sodium nitrite; (2) a chlorinated hydrocarbon mixture; (3) a simulant liquid scintillation fluid; and (4) a mixture of ketones. The testing protocol involved exposing the respective materials to 286,000 rads of gamma radiation followed by 14-day exposures to the waste types at 60{degrees}C. The seal materials were tested using vapor transport rate (VTR) measurements while the liner materials were tested using specific gravity as a metric. For these tests, a screening criterion of 0.9 g/hr/m{sup 2} for VTR and a specific gravity change of 10% was used. Based on this work, it was concluded that while all seal materials passed exposure to the aqueous simulant mixed waste, EPDM and SBR had the lowest VTRs. In the chlorinated hydrocarbon simulant mixed waste, only Viton passed the screening tests. In both the simulant scintillation fluid mixed waste and the ketone mixture simulant mixed waste, none of the seal materials met the screening criteria. For specific gravity testing of liner materials, the data showed that while all materials with the exception of polypropylene passed the screening criteria, Kel-F, HDPE, and XLPE offered the greatest resistance to the combination of radiation and chemicals.

  10. HUD CHP GUIDE #2 - FEASIBILITY SCREENING FOR CHP IN MULTIFAMILY...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    screening exercise and shows the screens for the feasibility screening tool, computer software prepared for HUD by the Oak Ridge National Laboratory (ORNL). chpguide2.pdf...

  11. Portuguese Ships on Japanese Namban Screens 

    E-Print Network [OSTI]

    Yamafune, Kotaro

    2012-10-19T23:59:59.000Z

    scenes of the first European activities in Japan. Among the subjects depicted on Namban screens, some of the most intriguing are ships: the European ships of the Age of Discovery. Namban screens were created by skillful Japanese traditional painters who...

  12. DOE: Former Worker Medical Screening Program (FWP)

    Broader source: Energy.gov [DOE]

    FWP provides no-cost medical screenings to all former DOE Federal, contractor and subcontractor employees. The screening exams are offered by third party providers from universities, labor unions,...

  13. Portuguese Ships on Japanese Namban Screens

    E-Print Network [OSTI]

    Yamafune, Kotaro

    2012-10-19T23:59:59.000Z

    scenes of the first European activities in Japan. Among the subjects depicted on Namban screens, some of the most intriguing are ships: the European ships of the Age of Discovery. Namban screens were created by skillful Japanese traditional painters who...

  14. Generalized charge-screening in relativistic Thomas–Fermi model

    SciTech Connect (OSTI)

    Akbari-Moghanjoughi, M. [Department of Physics, Faculty of Sciences, Azarbaijan Shahid Madani University, 51745-406 Tabriz, Iran and International Centre for Advanced Studies in Physical Sciences and Institute for Theoretical Physics, Ruhr University Bochum, D-44780 Bochum (Germany)

    2014-10-15T23:59:59.000Z

    In this paper, we study the charge shielding within the relativistic Thomas-Fermi model for a wide range of electron number-densities and the atomic-number of screened ions. A generalized energy-density relation is obtained using the force-balance equation and taking into account the Chandrasekhar's relativistic electron degeneracy pressure. By numerically solving a second-order nonlinear differential equation, the Thomas-Fermi screening length is investigated, and the results are compared for three distinct regimes of the solid-density, warm-dense-matter, and white-dwarfs (WDs). It is revealed that our nonlinear screening theory is compatible with the exponentially decaying Thomas-Fermi-type shielding predicted by the linear response theory. Moreover, the variation of relative Thomas-Fermi screening length shows that extremely dense quantum electron fluids are relatively poor charge shielders. Calculation of the total number of screening electrons around a nucleus shows that there is a position of maximum number of screening localized electrons around the screened nucleus, which moves closer to the point-like nucleus by increase in the plasma number density but is unaffected due to increase in the atomic-number value. It is discovered that the total number of screening electrons, (N{sub s}?r{sub TF}{sup 3}/r{sub d}{sup 3} where r{sub TF} and r{sub d} are the Thomas-Fermi and interparticle distance, respectively) has a distinct limit for extremely dense plasmas such as WD-cores and neutron star crusts, which is unique for all given values of the atomic-number. This is equal to saying that in an ultrarelativistic degeneracy limit of electron-ion plasma, the screening length couples with the system dimensionality and the plasma becomes spherically self-similar. Current analysis can provide useful information on the effects of relativistic correction to the charge screening for a wide range of plasma density, such as the inertial-confined plasmas and compact stellar objects.

  15. Updating Interconnection Screens for PV System Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron SpinPrinceton PlasmaAfternoon TalksDigitalRevisionof Energy |Michael

  16. Undergraduate research semester internship spring 1999 abstracts and research papers

    SciTech Connect (OSTI)

    Dibble, S; Fernandez, A; Mayers, C; Omikunle, A; Weiss, O

    1999-05-01T23:59:59.000Z

    This report consists of the following titles: (1) Development of Sieving Media for DNA Sequencing; (2) Protein-Protein Interaction Specificity of a Human Exonuclease; (3) Cascading Modular Biotreatment System--From Conceptual Design to Field Tests; (4) Detecting the Unseen Enemies--Biological Warfare; and (5) Development of a Functional Chip for High-Throughput Screening of Protein-DNA Interactions.

  17. MR SCREENING FORM FOR RESEARCH STAFF Page 1 of 2

    E-Print Network [OSTI]

    MR SCREENING FORM FOR RESEARCH STAFF Page 1 of 2 (PLEASE PRINT) NAME DATE: Before entering the MR environment or MR system room, you must remove all metallic objects including hearing aids, dentures, partial may be advised or required to wear earplugs or other hearing protection during the MR procedure

  18. Decision trees and integrated features for computer aided mammographic screening

    SciTech Connect (OSTI)

    Kegelmeyer, W.P. Jr.; Groshong, B.; Allmen, M.; Woods, K.

    1997-02-01T23:59:59.000Z

    Breast cancer is a serious problem, which in the United States causes 43,000 deaths a year, eventually striking 1 in 9 women. Early detection is the only effective countermeasure, and mass mammography screening is the only reliable means for early detection. Mass screening has many shortcomings which could be addressed by a computer-aided mammographic screening system. Accordingly, we have applied the pattern recognition methods developed in earlier investigations of speculated lesions in mammograms to the detection of microcalcifications and circumscribed masses, generating new, more rigorous and uniform methods for the detection of both those signs. We have also improved the pattern recognition methods themselves, through the development of a new approach to combinations of multiple classifiers.

  19. This new system will allow researchers to much more rapidly screen large numbers of samples and identify the most promising biomass feedstocks for higher efficiency and lower cost bio-

    E-Print Network [OSTI]

    of samples and identify the most promising biomass feedstocks for higher efficiency and lower cost bio- fuels conversion processes. NREL will be screening thousands of variants of different biomass feedstocks to link to develop the next generation of low-cost, easily convert- ible biomass feedstocks. To identify superior

  20. Former worekrs' notification adn medical screening Hanford

    SciTech Connect (OSTI)

    Patricia Quinn

    2005-11-30T23:59:59.000Z

    CPWR is carrying out a screening program for former Hanford construction workers. This program includes continuing screening and re-screening services for the former worker population. The Program contains the following general components: Start-up planning/needs assessment: A modified exposure assessment will be conducted to identify high-risk buildings or areas, primary exposures, and worker populations at risk. Outreach: CPWR, as the research arm of the Building and Construction Trades Department, AFL-CIO, has direct access to workers. CPWR will rely on direct mailings to lists of former workers, and work through and rely on existing organizations (unions, union pension funds, employers, DOE site administrators, etc.) to reach former workers and "get the word out." CPWR will establish/maintain an outreach office at each site listed above. This office will serve as the face of the Program to workers and their communities. Communications and intake center: CPWR has two established toll-free phone numbers (1-800-866-9663 and 1-888-464-0009). There is also a dedicated website for the program (btmed.org). Workers can register with the Program by mail, telephone, or on-line. Work history: A standardized, structured work history is administered with modules that accommodate unique exposure scenarios for different occupations and different DOE sites. A work history interview is administered by a trained program interviewer. The work histories are used to determine whether a participant is eligible for the medical examination and to interpret the findings from the medical examination. Medical evaluation: The Program contracts with local medical providers qualified to deliver occupational medical screening services. All providers are credentialed. The Program contracts with a certified national laboratory and with NIOSH certified B-readers to review x-rays. Based on the work history, the participant is referred to a credentialed medical provider who is located close to the participant's home. If it is not convenient to use a credentialed provider, the Program will make arrangements, if necessary, for the participant to receive a physical exam through the National Supplemental Screening Program. Eligible participants will receive the same core medical exam (including a Beryllium Lymphocyte Proliferation Test, BeLPT), and in addition, based on their work history, they may be assigned to exposure specific modules for asbestos, silica, lead, noise, cadmium, and chromium. Lab work will be sent to a national laboratory for processing, except the blood samples for the BeLPT, which will be sent to a DOE-approved laboratory for evaluation. Determination of work-relatedness and follow-up: A letter of findings will be sent to the participant within 60 days of the exam. The letter is written and/or reviewed by occupational medical health personnel with knowledge of the DOE site(s) where the participant has worked and will include specific follow-up recommendations. Urgent findings are followed up by the provider without delay. Evaluation and quality assurance: All data are entered into the Program Data Management System (DMS). The DMS is web-based and relies on electronic submission of results, whenever possible. A de-identified data set on all participants is provided to Duke University Medical Center for evaluation and analysis. Each participant is asked to complete a satisfaction survey. The DMS will be used for quality assurance purposes and to also report summary data to the DOE. The BTMED.ORG website is encrypted using the industry-standard Secure Sockets Layer (SSL) technology (128-bit encryption keys). Each individual that accesses the website is assigned a unique login ID, password, and token. Passwords are required to meet standards for "strength," including minimum length, multi-case, and use of numbers. The website is also protected by additional security layers including additional encryption, hardware and software firewalls, Virtual Private Networks (VPNs), and virus protection.

  1. Reverberatory screen for a radiant burner

    DOE Patents [OSTI]

    Gray, Paul E. (North East, MD)

    1999-01-01T23:59:59.000Z

    The present invention relates to porous mat gas fired radiant burner panels utilizing improved reverberatory screens. The purpose of these screens is to boost the overall radiant output of the burner relative to a burner using no screen and the same fuel-air flow rates. In one embodiment, the reverberatory screen is fabricated from ceramic composite material, which can withstand higher operating temperatures than its metallic equivalent. In another embodiment the reverberatory screen is corrugated. The corrugations add stiffness which helps to resist creep and thermally induced distortions due to temperature or thermal expansion coefficient differences. As an added benefit, it has been unexpectedly discovered that the corrugations further increase the radiant efficiency of the burner. In a preferred embodiment, the reverberatory screen is both corrugated and made from ceramic composite material.

  2. Screen Electrode Materials & Cell Chemistries and Streamlining...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    & Cell Chemistries and Streamlining Optimization of Electrode Screen Electrode Materials & Cell Chemistries and Streamlining Optimization of Electrode 2010 DOE Vehicle Technologies...

  3. Renormalization screening and collision-induced quantum interference in dense plasmas

    SciTech Connect (OSTI)

    Jung, Young-Dae, E-mail: ydjung@hanyang.ac.kr [Department of Applied Physics and Department of Bionanotechnology, Hanyang University, Ansan, Kyunggi-Do 426-791 (Korea, Republic of); Rasheed, A. [Department of Physics, Government College University, Faisalabad-38000 (Pakistan); Jamil, M. [Department of Physics, COMSATS Institute of Information Technology, Lahore 54000 (Pakistan)

    2014-07-15T23:59:59.000Z

    The influence of renormalization screening and collision-induced quantum interference in electron-electron collisions is investigated in partially ionized dense hydrogen plasmas. The effective interaction potential with the total spin-states of the collision system is considered to obtain the differential electron-electron scattering cross section. The results show that the renormalization plasma screening effect suppresses the electron-electron scattering cross section, including the quantum interference effect, especially, except for the forward and backward scattering directions. It is also shown that the renormalization plasma screening effect on the scattering cross section decreases with increasing collision energy. However, the renormalization screening effect is found to be important for the forward directions in the scattering cross section neglecting the quantum interference effect. The variations of the renormalization screening and collision-induced quantum interference effects are also discussed.

  4. Page 1 of 100 Full Screen

    E-Print Network [OSTI]

    Römisch, Werner

    ()d. #12;Home Page Title Page Contents Page 7 of 100 Go Back Full Screen Close Quit The behavior of bothHome Page Title Page Contents Page 1 of 100 Go Back Full Screen Close Quit Scenario Generation Uncertainty Quantification in Industrial and Energy Applications: Experiences and Challenges, Minneapolis

  5. NARES CULTURE FOR MRSA SCREENING I. INTRODUCTION

    E-Print Network [OSTI]

    Kay, Mark A.

    NARES CULTURE FOR MRSA SCREENING I. INTRODUCTION Active Surveillance Testing (AST) to detect newly admitted patients who are nasally colonized with MRSA is required in 2009 to comply with California Health an anterior nares specimen for MRSA screening. III. SUPPLIES 1. For children, adolescents and adults: BD BBL

  6. Automated imaging system for single molecules

    DOE Patents [OSTI]

    Schwartz, David Charles; Runnheim, Rodney; Forrest, Daniel

    2012-09-18T23:59:59.000Z

    There is provided a high throughput automated single molecule image collection and processing system that requires minimal initial user input. The unique features embodied in the present disclosure allow automated collection and initial processing of optical images of single molecules and their assemblies. Correct focus may be automatically maintained while images are collected. Uneven illumination in fluorescence microscopy is accounted for, and an overall robust imaging operation is provided yielding individual images prepared for further processing in external systems. Embodiments described herein are useful in studies of any macromolecules such as DNA, RNA, peptides and proteins. The automated image collection and processing system and method of same may be implemented and deployed over a computer network, and may be ergonomically optimized to facilitate user interaction.

  7. Observation of finite-wavelength screening in high-energy-density matter

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Chapman, D. A.; Vorberger, J.; Fletcher, L. B.; Baggott, R. A.; Divol, L.; Döppner, T.; Falcone, R. W.; Glenzer, S. H.; Gregori, G.; Guymer, T. M.; et al

    2015-04-23T23:59:59.000Z

    A key component for the description of charged particle systems is the screening of the Coulomb interaction between charge carriers. First investigated in the 1920s by Debye and Hückel for electrolytes, charge screening is important for determining the structural and transport properties of matter as diverse as astrophysical and laboratory plasmas, nuclear matter such as quark-gluon plasmas, electrons in solids, planetary cores and charged macromolecules. For systems with negligible dynamics, screening is still mostly described using a Debye–Hückel-type approach. Here, we report the novel observation of a significant departure from the Debye–Hückel-type model in high-energy-density matter by probing laser-driven, shock-compressedmore »plastic with high-energy X-rays. We use spectrally resolved X-ray scattering in a geometry that enables direct investigation of the screening cloud, and demonstrate that the observed elastic scattering amplitude is only well described within a more general approach.« less

  8. Combinatorial Approach for Hydrogen Storage Materials (presentation...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Center of Excellence Recommended Best Practices for the Characterization of Storage Properties of Hydrogen Storage Materials High ThroughputCombinatorial Screening of...

  9. A Better Drop to Drink | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    into high throughput for rapid screening for exposure to radiation, as well as bioremediation efforts that either remove heavy-metal contaminants or retard their mobility. Both...

  10. U.S. Department of Energy Categorical Exclusion Determination...

    Broader source: Energy.gov (indexed) [DOE]

    2) LBNL & Wildcat Disc. Tech - High Throughput Tools to Screen New Metal Organic Framework Materials Location: California Proposed Action or Project Description: American Recovcl)'...

  11. artificial neural analysis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Databases and Resources Websites Summary: Applications of Artificial Neural Networks and Fuzzy Models in High Throughput Screening to the existing HTS method, via Quantitative...

  12. What is Systems Biology? Computational Biology Laboratory

    E-Print Network [OSTI]

    Lee, H.C. Paul

    of high-throughput experimental techniques ­ micro-array (1995), mass spectrometry of proteins (1987), 2D* Proteins, energy, functions, etc. Building Blueprint Machines & workers Energy & supplies Physical plant ­gene-disruption data ·(protein­protein interaction) yeast two- hybrid data ·Many high-throughput exp

  13. antenatal screening lessons: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Subsequent screening should be done in accordance with CDC guidelines. Specific testing for HIV-2 should be conducted for refugees who screen positive for HIV and are native...

  14. HT Combinatorial Screening of Novel Materials for High Capacity...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    HT Combinatorial Screening of Novel Materials for High Capacity Hydrogen Storage HT Combinatorial Screening of Novel Materials for High Capacity Hydrogen Storage Presentation for...

  15. Renewable Energy Resource Maps and Screening Tools | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Resource Maps and Screening Tools Renewable Energy Resource Maps and Screening Tools Renewable energy resources are available across the United States but vary greatly depending on...

  16. Disposable Carbon Nanotube Modified Screen-Printed Biosensor...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Carbon Nanotube Modified Screen-Printed Biosensor for Amperometric Detection of Organophosphorus Pesticides and Nerve Disposable Carbon Nanotube Modified Screen-Printed Biosensor...

  17. Voltammetric Analysis of Europium at Screen-Printed Electrodes...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Voltammetric Analysis of Europium at Screen-Printed Electrodes Modified with Salicylamide Self-Assembled on Mesoporous Silica. Voltammetric Analysis of Europium at Screen-Printed...

  18. ANALYSIS OF DUST DELIQUESCENCE FOR FEP SCREENING

    SciTech Connect (OSTI)

    C. Bryan

    2005-08-26T23:59:59.000Z

    The purpose of this report is to evaluate the potential for penetration of the Alloy 22 (UNS N06022) waste package outer barrier by localized corrosion due to the deliquescence of soluble constituents in dust present on waste package surfaces. The results support a recommendation to exclude deliquescence-induced localized corrosion (pitting or crevice corrosion) of the outer barrier from the total system performance assessment for the license application (TSPA-LA). Preparation of this report, and supporting laboratory studies and calculations, were performed as part of the planned effort in Work Package AEBM21, as implemented in ''Technical Work Plan for: Screening Evaluation for Dust Deliquescence and Localized Corrosion'' (BSC 2004 [DIRS 172804]), by Bechtel SAIC Company, LLC, and staff from three national laboratories: Sandia National Laboratories, Lawrence Livermore National Laboratory (LLNL), and Lawrence Berkeley National Laboratory (LBNL). The analysis and conclusions presented in this report are quality affecting, as determined in the controlling technical work plan. A summary of background information, based on work that was not performed under a quality assurance program, is provided as Appendix E. In this instance, the use of unqualified information is provided for transparency and corroboration only, and is clearly separated from uses of qualified information. Thus, the qualification status of this information does not affect the conclusions of this report. The acceptance criteria addressed in Sections 4.2 and 7.2 were changed from the technical work plan in response to review comments received during preparation of this report.

  19. Power System Extreme Event Detection: The Vulnerability Frontier

    E-Print Network [OSTI]

    Lesieutre, Bernard C.; Pinar, Ali; Roy, Sandip

    2007-01-01T23:59:59.000Z

    Screening in Electric Power Systems,” submitted to theIEEE Transactions on Power Systems. [3] Lesieutre, B.C. , S.Donde, and A. Pinar, “Power System Extreme Event Screening

  20. Screening citrus rootstocks for alkalinity tolerance

    E-Print Network [OSTI]

    Sudahono

    1991-01-01T23:59:59.000Z

    SCREENING CITRUS ROOTSTOCKS FOR ALKALINITY TOLERANCE A Thesis by SUDAHONO Submitted to the Office of Graduate Studies of Texas ALM University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE August 1991 Major... Subject: Horticulture SCREENING CITRUS ROOTSTOCKS FOR ALKALINITY TOLERANCE A Thesis by SUDAHONO Approved as to style and content by: David H. yr (Chair of Com ttee) Robert E. Rouse (Member) ~. Err. tg~i ~PI. ~~ Frank M. Hone (Member) Calvin G...

  1. Miniaturization in Screening A Microfluidic Approach for Screening

    E-Print Network [OSTI]

    Ismagilov, Rustem F.

    equipment for varying flow rates, and even though such equipment could be as simple as a few computer vary significantly. We used a three-phase liquid/liquid/gas system to enhance reliability

  2. Qualitative vs. quantitative data: Controls on the accuracy of PID field screening in petroleum contamination assessment applications

    SciTech Connect (OSTI)

    Luessen, M.J.; Allex, M.K.; Holzel, F.R. [ATEC Associates Inc., Cincinnati, OH (United States)

    1995-09-01T23:59:59.000Z

    The use of photoionization detectors (PIDs) for field screening of soils for volatile organic contaminants has become a standard industry practice. PID screening data is generally utilized as a qualitative basis for selection of samples for laboratory analysis to quantify concentrations of specific contaminants of concern. Both qualitative field screening data and quantitative laboratory analytical data were reviewed for more than 100 hydrogeologic assessment sites in Ohio to evaluate controls on the effectiveness of field screening data. Assessment data evaluated was limited to sites at which the suspected contaminant source was a gasoline underground storage tanks system. In each case, a 10.0 eV (or greater) PID calibrated for benzene was used to screen soils which were analyzed for benzene, toluene, ethylbenzene and xylene (BTEX) by SW 846 method 8020. Controls on field screening which were evaluated for each site included (1) soil classification, (2) soil moisture, (3) weather conditions, (4) background levels, (5) equipment quality, (6) screening methodology, and (7) laboratory QA/QC. Statistical data analysis predictably indicated a general overestimate of total BTEX levels based on field screening (gasoline is approximately 25 weight percent BTEX). However, data locally indicated cases of both significant (i.e., more than an order of magnitude difference) over- and under-estimation of actual BTEX concentrations (i.e., quantitative laboratory data) by field screening data.

  3. Reactor control system upgrade for the McClellan Nuclear Radiation Center Sacramento, CA.

    SciTech Connect (OSTI)

    Power, M. A.

    1999-03-10T23:59:59.000Z

    Argonne National Laboratory is currently developing a new reactor control system for the McClellan Nuclear Radiation Facility. This new control system not only provides the same functionality as the existing control system in terms of graphic displays of reactor process variables, data archival capability, and manual, automatic, pulse and square-wave modes of operation, but adds to the functionality of the previous control system by incorporating signal processing algorithms for the validation of sensors and automatic calibration and verification of control rod worth curves. With the inclusion of these automated features, the intent of this control system is not to replace the operator but to make the process of controlling the reactor easier and safer for the operator. For instance, an automatic control rod calibration method reduces the amount of time to calibrate control rods from days to minutes, increasing overall reactor utilization. The control rod calibration curve, determined using the automatic calibration system, can be validated anytime after the calibration, as long as the reactor power is between 50W and 500W. This is done by banking all of the rods simultaneously and comparing the tabulated rod worth curves with a reactivity computer estimate. As long as the deviation between the tabulated values and the reactivity estimate is within a prescribed error band, then the system is in calibration. In order to minimize the amount of information displayed, only the essential flux-related data are displayed in graphical format on the control screen. Information from the sensor validation methods is communicated to the operators via messages, which appear in a message window. The messages inform the operators that the actual process variables do not correlate within the allowed uncertainty in the reactor system. These warnings, however, cannot cause the reactor to shutdown automatically. The reactor operator has the ultimate responsibility of using this information to either keep the reactor operating or to shut the reactor down. In addition to new developments in the signal processing realm, the new control system will be migrating from a PC-based computer platform to a Sun Solaris-based computer platform. The proven history of stability and performance of the Sun Sohuis operating system are the main advantages to this change. The I/O system will also be migrating from a PC-based data collection system, which communicates plant data to the control computer using RS-232 connections, to an Ethernet-based I/O system. The Ethernet Data Acquisition System (EDAS) modules from Intelligent Instrumentation, Inc. provide an excellent solution for embedded control of a system using the more universally-accepted data transmission standard of TCP/IP. The modules contain a PROM, which operates all of the functionality of the I/O module, including the TCP/IP network access. Thus the module does not have an internal, sophisticated operating system to provide functionality but rather a small set hard-coded of instructions, which almost eliminates the possibility of the module failing due to software problems. An internal EEPROM can be modified over the Internet to change module configurations. Once configured, the module is contacted just like any other Internet host using TCP/IP socket calls. The main advantage to this architecture is its flexibility, expandability, and high throughput.

  4. Screening Level Risk Assessment for the New Waste Calcining Facility

    SciTech Connect (OSTI)

    M. L. Abbott; K. N. Keck; R. E. Schindler; R. L. VanHorn; N. L. Hampton; M. B. Heiser

    1999-05-01T23:59:59.000Z

    This screening level risk assessment evaluates potential adverse human health and ecological impacts resulting from continued operations of the calciner at the New Waste Calcining Facility (NWCF) at the Idaho Nuclear Technology and Engineering Center (INTEC), Idaho National Engineering and Environmental Laboratory (INEEL). The assessment was conducted in accordance with the Environmental Protection Agency (EPA) report, Guidance for Performing Screening Level Risk Analyses at Combustion Facilities Burning Hazardous Waste. This screening guidance is intended to give a conservative estimate of the potential risks to determine whether a more refined assessment is warranted. The NWCF uses a fluidized-bed combustor to solidify (calcine) liquid radioactive mixed waste from the INTEC Tank Farm facility. Calciner off volatilized metal species, trace organic compounds, and low-levels of radionuclides. Conservative stack emission rates were calculated based on maximum waste solution feed samples, conservative assumptions for off gas partitioning of metals and organics, stack gas sampling for mercury, and conservative measurements of contaminant removal (decontamination factors) in the off gas treatment system. Stack emissions were modeled using the ISC3 air dispersion model to predict maximum particulate and vapor air concentrations and ground deposition rates. Results demonstrate that NWCF emissions calculated from best-available process knowledge would result in maximum onsite and offsite health and ecological impacts that are less then EPA-established criteria for operation of a combustion facility.

  5. Species for the screening assessment. Columbia River Comprehensive Impact Assessment

    SciTech Connect (OSTI)

    Becker, J.M.; Brandt, C.A.; Dauble, D.D.; Maughan, A.D.; O`Neil, T.K.

    1996-03-01T23:59:59.000Z

    Because of past nuclear production operations along the Columbia River, there is intense public and tribal interest in assessing any residual Hanford Site related contamination along the river from the Hanford Reach to the Pacific Ocean. The Columbia River Comprehensive Impact Assessment was proposed to address these concerns. The assessment of the Columbia River is being conducted in phases. The initial phase is a screening assessment of the risk, which addresses current environmental conditions for a range of potential uses. One component of the screening assessment estimates the risk from contaminants in the Columbia River to the environment. The objective of the ecological risk assessment is to determine whether contaminants from the Columbia River pose a significant threat to selected receptor species that exist in the river and riparian communities of the study area. This report (1) identifies the receptor species selected for the screening assessment of ecological risk and (2) describes the selection process. The species selection process consisted of two tiers. In Tier 1, a master species list was developed that included many plant and animal species known to occur in the aquatic and riparian systems of the Columbia River between Priest Rapids Dam and the Columbia River estuary. This master list was reduced to 368 species that occur in the study area (Priest Rapids Dam to McNary Dam). In Tier 2, the 181 Tier 1 species were qualitatively ranked based on a scoring of their potential exposure and sensitivity to contaminants using a conceptual exposure model for the study area.

  6. Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds

    E-Print Network [OSTI]

    Goodell, John R.

    An automated, silicon-based microreactor system has been developed for rapid, low-volume, multidimensional reaction screening. Use of the microfluidic platform to identify transformations of densely functionalized bicyclo ...

  7. Quantum corrections to screening at strong coupling

    E-Print Network [OSTI]

    Ajay Singh; Aninda Sinha

    2012-04-23T23:59:59.000Z

    We compute a certain class of corrections to (specific) screening lengths in strongly coupled nonabelian plasmas using the AdS/CFT correspondence. In this holographic framework, these corrections arise from various higher curvature interactions modifying the leading Einstein gravity action. The changes in the screening lengths are perturbative in inverse powers of the 't Hooft coupling or of the number of colours, as can be made precise in the context where the dual gauge theory is superconformal. We also compare the results of these holographic calculations to lattice results for the analogous screening lengths in QCD. In particular, we apply these results within the program of making quantitative comparisons between the strongly coupled quark-gluon plasma and holographic descriptions of conformal field theory.

  8. Screening the Hanford tanks for trapped gas

    SciTech Connect (OSTI)

    Whitney, P.

    1995-10-01T23:59:59.000Z

    The Hanford Site is home to 177 large, underground nuclear waste storage tanks. Hydrogen gas is generated within the waste in these tanks. This document presents the results of a screening of Hanford`s nuclear waste storage tanks for the presence of gas trapped in the waste. The method used for the screening is to look for an inverse correlation between waste level measurements and ambient atmospheric pressure. If the waste level in a tank decreases with an increase in ambient atmospheric pressure, then the compressibility may be attributed to gas trapped within the waste. In this report, this methodology is not used to estimate the volume of gas trapped in the waste. The waste level measurements used in this study were made primarily to monitor the tanks for leaks and intrusions. Four measurement devices are widely used in these tanks. Three of these measure the level of the waste surface. The remaining device measures from within a well embedded in the waste, thereby monitoring the liquid level even if the liquid level is below a dry waste crust. In the past, a steady rise in waste level has been taken as an indicator of trapped gas. This indicator is not part of the screening calculation described in this report; however, a possible explanation for the rise is given by the mathematical relation between atmospheric pressure and waste level used to support the screening calculation. The screening was applied to data from each measurement device in each tank. If any of these data for a single tank indicated trapped gas, that tank was flagged by this screening process. A total of 58 of the 177 Hanford tanks were flagged as containing trapped gas, including 21 of the 25 tanks currently on the flammable gas watch list.

  9. Internship FBI Fingerprint Procedures and Additional Screenings

    E-Print Network [OSTI]

    Gering, Jon C.

    Internship FBI Fingerprint Procedures and Additional Screenings ALL INTERNS: Required by DESE/Full-Year Internship) or August 1st (Spring Internship) o Web application https to get your fingerprints taken for your internship: 4 digit Registration #2301 Cost - $44.80 Valid

  10. Quantum Key Distribution with Screening and Analyzing

    E-Print Network [OSTI]

    Won-Ho Kye

    2006-10-04T23:59:59.000Z

    We propose a quantum key distribution scheme by using screening angles and analyzing detectors which enable to notice the presence of Eve who eavesdrops the quantum channel, as the revised protocol of the recent quantum key distribution [Phys. Rev. Lett. 95, 040501 (2005)]. We discuss the security of the proposed quantum key distribution against various attacks including impersonation attack and Trojan Horse attack.

  11. Screening and Evaluation Tool (SET) Users Guide

    SciTech Connect (OSTI)

    Layne Pincock

    2014-10-01T23:59:59.000Z

    This document is the users guide to using the Screening and Evaluation Tool (SET). SET is a tool for comparing multiple fuel cycle options against a common set of criteria and metrics. It does this using standard multi-attribute utility decision analysis methods.

  12. D & D screening risk evaluation guidance

    SciTech Connect (OSTI)

    Robers, S.K.; Golden, K.M.; Wollert, D.A.

    1995-09-01T23:59:59.000Z

    The Screening Risk Evaluation (SRE) guidance document is a set of guidelines provided for the uniform implementation of SREs performed on decontamination and decommissioning (D&D) facilities. Although this method has been developed for D&D facilities, it can be used for transition (EM-60) facilities as well. The SRE guidance produces screening risk scores reflecting levels of risk through the use of risk ranking indices. Five types of possible risk are calculated from the SRE: current releases, worker exposures, future releases, physical hazards, and criticality. The Current Release Index (CRI) calculates the current risk to human health and the environment, exterior to the building, from ongoing or probable releases within a one-year time period. The Worker Exposure Index (WEI) calculates the current risk to workers, occupants and visitors inside contaminated D&D facilities due to contaminant exposure. The Future Release Index (FRI) calculates the hypothetical risk of future releases of contaminants, after one year, to human health and the environment. The Physical Hazards Index (PHI) calculates the risks to human health due to factors other than that of contaminants. Criticality is approached as a modifying factor to the entire SRE, due to the fact that criticality issues are strictly regulated under DOE. Screening risk results will be tabulated in matrix form, and Total Risk will be calculated (weighted equation) to produce a score on which to base early action recommendations. Other recommendations from the screening risk scores will be made based either on individual index scores or from reweighted Total Risk calculations. All recommendations based on the SRE will be made based on a combination of screening risk scores, decision drivers, and other considerations, as determined on a project-by-project basis.

  13. The ALICE analysis train system

    E-Print Network [OSTI]

    Markus Zimmermann; for the ALICE collaboration

    2015-02-23T23:59:59.000Z

    In the ALICE experiment hundreds of users are analyzing big datasets on a Grid system. High throughput and short turn-around times are achieved by a centralized system called the LEGO trains. This system combines analysis from different users in so-called analysis trains which are then executed within the same Grid jobs thereby reducing the number of times the data needs to be read from the storage systems. The centralized trains improve the performance, the usability for users and the bookkeeping in comparison to single user analysis. The train system builds upon the already existing ALICE tools, i.e. the analysis framework as well as the Grid submission and monitoring infrastructure. The entry point to the train system is a web interface which is used to configure the analysis and the desired datasets as well as to test and submit the train. Several measures have been implemented to reduce the time a train needs to finish and to increase the CPU efficiency.

  14. National Security Science and Technology Initiative: Air Cargo Screening

    SciTech Connect (OSTI)

    Bingham, Philip R [ORNL; White, Tim [Pacific Northwest National Laboratory (PNNL); Cespedes, Ernesto [Idaho National Laboratory (INL); Bowerman, Biays [Brookhaven National Laboratory (BNL); Bush, John [Battelle

    2010-11-01T23:59:59.000Z

    The non-intrusive inspection (NII) of consolidated air cargo carried on commercial passenger aircraft continues to be a technically challenging, high-priority requirement of the Department of Homeland Security's Science and Technology Directorate (DHS S&T), the Transportation Security Agency and the Federal Aviation Administration. The goal of deploying a screening system that can reliably and cost-effectively detect explosive threats in consolidated cargo without adversely affecting the flow of commerce will require significant technical advances that will take years to develop. To address this critical National Security need, the Battelle Memorial Institute (Battelle), under a Cooperative Research and Development Agreement (CRADA) with four of its associated US Department of Energy (DOE) National Laboratories (Oak Ridge, Pacific Northwest, Idaho, and Brookhaven), conducted a research and development initiative focused on identifying, evaluating, and integrating technologies for screening consolidated air cargo for the presence of explosive threats. Battelle invested $8.5M of internal research and development funds during fiscal years 2007 through 2009. The primary results of this effort are described in this document and can be summarized as follows: (1) Completed a gap analysis that identified threat signatures and observables, candidate technologies for detection, their current state of development, and provided recommendations for improvements to meet air cargo screening requirements. (2) Defined a Commodity/Threat/Detection matrix that focuses modeling and experimental efforts, identifies technology gaps and game-changing opportunities, and provides a means of summarizing current and emerging capabilities. (3) Defined key properties (e.g., elemental composition, average density, effective atomic weight) for basic commodity and explosive benchmarks, developed virtual models of the physical distributions (pallets) of three commodity types and three explosive benchmarks combinations, and conducted modeling and simulation studies to begin populating the matrix of commodities, threats, and detection technologies. (4) Designed and fabricated basic (homogeneous) commodity test pallets and fabricated inert stimulants to support experiments and to validate modeling/simulation results. (5) Developed/expanded the team's capabilities to conduct full-scale imaging (neutron and x-ray) experiments of air cargo commodities and explosive benchmarks. (6) Conducted experiments to improve the collection of trace particles of explosives from a variety of surfaces representative of air cargo materials by means of mechanical (air/vibration/pressure), thermal, and electrostatic methods. Air cargo screening is a difficult challenge that will require significant investment in both research and development to find a suitable solution to ensure the safety of passengers without significantly hindering the flow of commodities. The initiative funded by Battelle has positioned this group to make major contributions in meeting the air cargo challenge by developing collaborations, developing laboratory test systems, improving knowledge of the challenges (both technical and business) for air cargo screening, and increasing the understanding of the capabilities for current inspection methods (x-ray radiography, x-ray backscatter, etc.) and potential future inspection methods (neutron radiography, fusion of detector modalities, advanced trace detection, etc.). Lastly, air cargo screening is still an issue that will benefit from collaboration between Department of Energy Laboratories and Battelle. On January 7, 2010, DHS Secretary Napolitano joined White House Press Secretary Robert Gibbs and Assistant to the President for Counterterrorism and Homeland Security John Brennan to announce several recommendations DHS has made to the President for improving the technology and procedures used to protect air travel from acts of terrorism. (This announcement followed the 25 Dec'09 Delta/Northwest Airlines Flight 253 terror attack.) Secretary Napolitano out

  15. Laboratory to change vehicle traffic-screening regimen at vehicle...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Changes to vehicle traffic-screening Laboratory to change vehicle traffic-screening regimen at vehicle inspection station Lanes two through five will be open 24 hours a day and...

  16. Microfluidic in vivo screen identifies compounds enhancing neuronal

    E-Print Network [OSTI]

    Haggarty, Stephen

    Compound screening is a powerful tool to identify new therapeutic targets, drug leads, and elucidate the fundamental mechanisms of biological processes. We report here the results of the first in vivo small-molecule screens ...

  17. Weakly screened thermonuclear reactions in astrophysical plasmas: Improving Salpeter's model

    E-Print Network [OSTI]

    Theodore E. Liolios

    2003-06-23T23:59:59.000Z

    This paper presents a detailed study of the electron degeneracy and nonlinear screening effects which play a crucial role in the validity of Salpeter's weak-screening model. The limitations of that model are investigated and an improved one is proposed which can take into account nonlinear screening effects. Its application to the solar pp reaction derives an accurate screening enhancement factor and provides a very reliable estimation of the associated neutrino flux uncertanties.

  18. A Semiconductor Microlaser for Intracavity Flow Cytometry

    SciTech Connect (OSTI)

    Akhil, O.; Copeland, G.C.; Dunne, J.L.; Gourley, P.L.; Hendricks, J.K.; McDonald, A.E.

    1999-01-20T23:59:59.000Z

    Semiconductor microlasers are attractive components for micro-analysis systems because of their ability to emit coherent intense light from a small aperture. By using a surface-emitting semiconductor geometry, we were able to incorporate fluid flow inside a laser microcavity for the first time. This confers significant advantages for high throughput screening of cells, particulates and fluid analytes in a sensitive microdevice. In this paper we discuss the intracavity microfluidics and present preliminary results with flowing blood and brain cells.

  19. Screening properties of four mesoscale smoothed charge models, with application to dissipative particle dynamics

    E-Print Network [OSTI]

    Patrick B. Warren; Andrey Vlasov

    2014-02-25T23:59:59.000Z

    We extend our previous study [J. Chem. Phys. 138, 204907 (2013)] to quantify the screening properties of four mesoscale smoothed charge models used in dissipative particle dynamics. Using a combination of the hypernetted chain integral equation closure and the random phase approximation, we identify regions where the models exhibit a real-valued screening length, and the extent to which this agrees with the Debye length in the physical system. We find that the second moment of the smoothed charge distribution is a good predictor of this behaviour. We are thus able to recommend a consistent set of parameters for the models.

  20. Electron Cloud with Inverted Beam Screens

    E-Print Network [OSTI]

    Maury Cuna, H

    2011-01-01T23:59:59.000Z

    We report the results of computer simulations studying the effect of wrongly oriented LHC beam screens on the local electron-cloud heat load and density. At 3.5 or 7-TeV energy and for maximum secondary emission-yield values below 1.5, with the inverted sawtooth orientation about ten times higher heat load is expected than for the standard orientation, and the wrongly oriented sawtooth chambers could lead to a local heat-load bottleneck during the process of surface conditioning at 25-ns bunch spacing. The available cooling margin can be significantly increased by correcting the sawtooth orientations at least for two dipole magnets in LHC arc cells 26 and 32 R3, in order that there be no half-cell cooling loop containing more than one inverted screen.

  1. Screening technology reduces ash in spiral circuits

    SciTech Connect (OSTI)

    Brodzik, P. [Derrick Corp., Buffalo, NY (United States)

    2007-05-15T23:59:59.000Z

    In 2006, the James River Coal Co. selected the Stack Sizer to remove the minus 100 mesh high ash clay fraction from the clean coal spiral product circuits at the McCoy-Elkhorn Bevins Branch prep plant and at the Blue Diamond Leatherwood prep plant in Kentucky. The Stack Sizer is a multi-deck, high-frequency vibrating screen capable of separations as fine as 75 microns when fitted with Derrick Corp.'s patented high open area urethane screen panels. Full-scale lab tests and more than 10 months of continuous production have confirmed that the Stack Sizer fitted with Derrick 100 micron urethane screen panels consistently produces a clean coal fraction that ranges from 8 to 10% ash. Currently, each five-deck Stack Sizer operating at the Bevins Branch and Leatherwood prep plants is producing approximately 33 tons per hour of clean coal containing about 9% ash. This represents a clean coal yield of about 75% and an ash reduction of about 11% from the feed slurry. 3 figs. 2 tabs.

  2. Dynamic screening correction for solar p-p reaction rates

    E-Print Network [OSTI]

    Mussack, Katie; 10.1088/0004-637X/729/2/96

    2011-01-01T23:59:59.000Z

    The solar abundance controversy inspires renewed investigations of the basic physics used to develop solar models. Here we examine the correction to the proton-proton reaction rate due to dynamic screening effects. Starting with the dynamic screening energy from the molecular-dynamics simulations of Mao et al., we compute a reaction-rate correction for dynamic screening. We find that, contrary to static screening theory, this dynamic screening does not significantly change the reaction rate from that of the bare Coulomb potential.

  3. Advanced Gas Cooled Nuclear Reactor Materials Evaluation and Development Program: Topical report I, selection of candidate alloys. Volume 3. Selection of surface coating/substrate systems for screening creep and structural stability studies

    SciTech Connect (OSTI)

    Not Available

    1980-06-20T23:59:59.000Z

    Considering the high temperature, low O/sub 2/, high C environment of operation in the Very High Temperature Reactor (VHTR) Systems, the utilization of coatings is envisaged to hold potential for extending component lifetimes through the formation of stable and continuous oxide films with enhanced resistance to C diffusion. A survey of the current state of technology for high temperature coatings has been performed. The usefulness of these coatings on the Mo, Ni, and Fe base alloys is discussed. Specifically, no coating substitute was identified for TZM other than the well known W-3 (pack silicide) and Al/sub 2/O/sub 3/ forming coatings were recommended for the Fe and Ni base structural materials. Recommendations as to coating types and processng have been made based on the predicted VHTR component size, shape, base metal and operational environment. Four tests designed to evaluate the effects of selected combinations of coatings and substrate matrices are recommended for consideration.

  4. Operations capability improvement of a molecular biology laboratory in a high throughput genome sequencing center

    E-Print Network [OSTI]

    Vokoun, Matthew R. (Matthew Richard)

    2005-01-01T23:59:59.000Z

    The Broad Institute is a research collaboration of MIT, Harvard University and affiliated hospitals, and the Whitehead Institute for Biomedical Research. Its scientific mission is to "(1) create tools for genomic medicine ...

  5. ComparativeComparative InteractomicsInteractomics comparative genomics of high throughput data

    E-Print Network [OSTI]

    Utrecht, Universiteit

    of quality of expert curation (to use as source or reference) and most prolific HTP data (complex mean absence of co- complex membership #12;Estimating absence of interactions from HTP dataEstimating absence of interactions from HTP data --> yeast; what do we call an absence of interaction data> yeast

  6. Real Time Pulse Pile-up Recovery in a High Throughput Digital Pulse Processor

    SciTech Connect (OSTI)

    Scoullar, Paul A. B.; McLean, Chris C. [Southern Innovation, Melbourne (Australia); Evans, Rob J. [Department of Electrical and Electronic Engineering, University of Melbourne (Australia)

    2011-12-13T23:59:59.000Z

    Detection and measurement of radiation is used extensively for non-invasive material characterization in a range of industries. However, many practical applications are frustrated by pulse pile-up within the detector. Pulse pile-up, which occurs when multiple radiation events arrive within the temporal resolving time of the detector, degrades the fidelity of subsequent material analysis. Traditional pulse processing techniques use fast digital filters and logic circuits to detect piled-up events and discard the corrupted data, however, this leads to substantial detector dead time. Consequently, there is considerable interest in more complex signal-processing algorithms to extend the performance of pulse processors and improve material characterization techniques. We present a technology for real-time decoding of pulse pile-up events. It is a model-based signal-processing algorithm able to accurately characterize the number, time-of-arrival and energy of all events in the detector output. Even in the presence of severe multi-pulse pile-up, the composite events are decoded and the energy and time-of-arrival recovered. The technology has been evaluated using a range of detectors, sources and count rates. An exceptional improvement over traditional pulse processing techniques is demonstrated.

  7. High-Throughput Automated Luminescent Magnetic Particle-Based Immunoassay to Monitor

    E-Print Network [OSTI]

    Hammock, Bruce D.

    immunoassay de- scribed here is sensitive, simple to use, and more rapid than the previously reported standard significantly reduce the time and labor required for chromato- graphic separation and detection of multiple

  8. Examination of mammalian microRNAs by high-throughput sequencing

    E-Print Network [OSTI]

    Chiang, HyoJin Rosaria

    2011-01-01T23:59:59.000Z

    Small non-coding RNAs play an important role in a wide range of cellular events. MicroRNAs (miRNAs) are an abundant class of small RNAs that post-transcriptionally repress expression of their target genes. Since miRNA ...

  9. Development of a high throughput 3D perfused liver tissue bioreactor

    E-Print Network [OSTI]

    Inman, Samuel Walker

    2006-01-01T23:59:59.000Z

    This thesis describes the development of a device designed for culturing liver tissue in a 3D perfused environment. Cells form tissue inside miniature channels of a scaffold, and the tissue is perfused with culture medium ...

  10. Geochip: A high throughput genomic tool for linking community structure to functions

    E-Print Network [OSTI]

    Van Nostrand, Joy D.

    2009-01-01T23:59:59.000Z

    soil samples from two oilfields, Daqing and Shengli, locatedall samples from the Daqing oilfield grouping together whilecommunity from the Shengli oilfield was separate (Figure 2),

  11. Database Requirements for Workflow Management in a HighThroughput Genome Laboratory 1

    E-Print Network [OSTI]

    Bonner, Anthony

    @genome.wi.mit.edu 2 University of Toronto Department of Computer Science 10 King's College Rd Toronto, ON, Canada M5S constitutes an audit trail, or event history, and has much the same function as a laboratory notebook number P50 HG00098, and from the U.S. Department of Energy under contract DE­FG02­95ER62101. 1 #12

  12. LabFlow1: a Database Benchmark for HighThroughput Workflow Management ?

    E-Print Network [OSTI]

    Bonner, Anthony

    @db.toronto.edu Adel Shrufi 1 shrufi@db.toronto.edu Steve Rozen 2 steve@genome.wi.mit.edu 1 University of Toronto of workflow activity. This DBMS maintains an audit trail, or event history, that records the results of each Genome Research, grant number P50 HG00098, and from the U.S. Department of Energy under contract DE­FG02

  13. LabFlow1: a Database Benchmark for HighThroughput Workflow Management \\Lambda

    E-Print Network [OSTI]

    Bonner, Anthony

    University of Toronto Department of Computer Science 10 King's College Rd Toronto, ON, Canada M5S 1A4 2 track of workflow activity. This DBMS maintains an audit trail, or event history, that records number P50 HG00098, and from the U.S. Department of Energy under contract DE­FG02­95ER62101. #12

  14. High-throughput approaches to sourcing of human hepatocytes for cell-based therapies

    E-Print Network [OSTI]

    Shan, Jing (Jing Meghan)

    2014-01-01T23:59:59.000Z

    Chronic liver disease affects more than 500 million people worldwide. The only therapy shown to directly prevent mortality is organ transplantation. However, there is growing discrepancy between supply and demand of ...

  15. The Development of a High-throughput Microdroplet Bioreactor Device for Microbial Studies

    E-Print Network [OSTI]

    Guzman, Adrian

    2012-10-19T23:59:59.000Z

    Current PCR Polymerase Chain Reaction MOS-FET Metal-Oxide-Semiconductor Field-Effect Transistor BSA Bovine Serum Albumin GFP Green Fluorescent Protein RFP Red Fluorescent Protein LED Light Emitting Diode PMT Photomultiplier Tubes...

  16. Ultra-high Throughput Real-time Instruments for Capturing Fast Signals and Rare Events

    E-Print Network [OSTI]

    Buckley, Brandon Walter

    2013-01-01T23:59:59.000Z

    from non-linear regression. . . . . . . . . . Conceptually,was estimated from non-linear regression. Un-Equalized RealRF band- width. A non-linear regression estimated the chirp

  17. High-throughput single-molecule fluorescence spectroscopy using parallel detection

    E-Print Network [OSTI]

    Michalet, Xavier

    -molecule imaging). In this section, we briefly discuss the technique and data analysis used in standard solution-based , S. Tisad , F. Zappad , S. Covad , S. Weissa a Dept of Chemistry & Biochemistry, Los Angeles, CA, USA 90095; b Nesher Technologies, Los Angeles, CA; c Dept of Physics & Astronomy, UCLA, Los Angeles, CA

  18. High-throughput metal nanoparticle catalysis by pulsed laser ablation Selim Senkan a,*, Michael Kahn a

    E-Print Network [OSTI]

    Senkan, Selim M.

    of propylene. In less than a day, over 40 different catalytic materials of nanoparticles supported on g-Al2O3 oxidation products of propylene with one-pass yields of about 13% at 275 8C. # 2006 Published by Elsevier B of propylene oxide from propylene, hydrogen and oxygen [5]. On the other hand, larger Au nanoparticles result

  19. High-throughput microfluidic living cell arrays for spatiotemporal gene expression profiling

    E-Print Network [OSTI]

    King, Kevin R. (Kevin Robert), 1976-

    2008-01-01T23:59:59.000Z

    The cellular microenvironment is remarkably complex. In the small space near each cell, growth factors are liberated from extracellular matrix, cytokines are secreted from neighboring cells, and hormones arrive from distant ...

  20. Technology assessment and feasibility study of high-throughput single cell force spectroscopy

    E-Print Network [OSTI]

    Cheng, He, M. Eng. Massachusetts Institute of Technology

    2010-01-01T23:59:59.000Z

    In the last decade, the field of single cell mechanics has emerged with the development of high resolution experimental and computational methods, providing significant amount of information about individual cells instead ...

  1. High-throughput detection of ethanol-producing cyanobacteria in a microdroplet platform

    E-Print Network [OSTI]

    Abalde-Cela, Sara; Gould, Anna; Liu, Xin; Kazamia, Elena; Smith, Alison G.; Abell, Chris

    2015-03-17T23:59:59.000Z

    crops such as maize or sugar cane [2]. In particular, bioethanol is emerging as one of the most promising non-fossil energy resources, due to its abil- ity to be a ‘drop-in’ fuel mixed with gasoline (petrol). However, bioethanol production from sugars... obtained from arable crops requires high land areas to meet the energy requirements and so competes with land for food production. As a consequence, the need for alternative bioethanol producers is a critical issue in the biofuel field [3,4]. Microalgae...

  2. Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray

    E-Print Network [OSTI]

    Hook, Andrew L.

    Atomic force microscopy has been applied to an acrylate polymer microarray to achieve a full topographic characterisation. This process discovered a small number of hydro-responsive materials created from monomers with ...

  3. Development and Application of a High Throughput Methodology to Characterize and Formulate Protein-Based Therapeutics

    E-Print Network [OSTI]

    Hu, Lei

    2012-12-31T23:59:59.000Z

    simultaneously, including UV absorption, light scattering, and near- and far- UV CD by employing a multimodal spectrometer (Chapter 2). Fluorescence spectral data are also collected on the same instrument although not simultaneously. The method is developed...

  4. analyzing high-throughput sequencing: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    biological sample analysis abundance variabilities within sample cohorts. Mass spectrometry (MS) based platforms have attracted Clemmer, David E. 11 The use of coded PCR...

  5. A high-throughput microfluidic device to study neurite response to growth factor gradients

    E-Print Network [OSTI]

    Kothapalli, Chandrasekhar R.

    Studying neurite guidance by diffusible or substrate bound gradients is challenging with current techniques. In this study, we present the design, fabrication and utility of a microfluidic device to study neurite guidance ...

  6. Cyber-T web server: differential analysis of high-throughput data

    E-Print Network [OSTI]

    Kayala, M. A; Baldi, P.

    2012-01-01T23:59:59.000Z

    10.1093/nar/gks420 Cyber-T web server: differential analysisin the Cyber-T web server, is one of the most widelyan update to the Cyber-T web server, incorporating several

  7. Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics

    E-Print Network [OSTI]

    Hughes, Travis K.

    An innovative, microwell-based platform for single-cell RNA sequencing (RNA-seq) combines cost efficiency, scalability and parallelizability, and will enable many new avenues of biological inquiry.

  8. PVD synthesis and high-throughput property characterization of Ni?Fe?Cr alloy libraries

    SciTech Connect (OSTI)

    Rar, A.; Frafjord, J.J.; Fowlkes, Jason D.; Specht, E.D.; Rack, P.D.; Santella, M.L.; Bei, H.; George, E.P.; Pharr, G.M. (Tennessee-K); (Tennessee-K); (ORNL)

    2010-11-10T23:59:59.000Z

    Three methods of alloy library synthesis, thick-layer deposition followed by interdiffusion, composition-spread codeposition and electron-beam melting of thick deposited layers, have been applied to Ni-Fe-Cr ternary and Ni-Cr binary alloys. Structural XRD mapping and mechanical characterization by means of nanoindentation have been used to characterize the properties of the libraries. The library synthesis methods are compared from the point of view of the structural and mechanical information they can provide.

  9. A GPU-Like Soft Processor for High-Throughput Acceleration

    E-Print Network [OSTI]

    Steffan, J. Gregory

    into a blade server platform, and XtremeData and Nallatech that offer FPGA accelerator modules that can of the implementation, testing, and debugging required for devel- oping real hardware. Behavioral synthesis techniques the advantages of (i) supporting a familiar programming model and environment and (ii) being portable across

  10. Air-stable ink for scalable, high-throughput layer deposition

    DOE Patents [OSTI]

    Weil, Benjamin D; Connor, Stephen T; Cui, Yi

    2014-02-11T23:59:59.000Z

    A method for producing and depositing air-stable, easily decomposable, vulcanized ink on any of a wide range of substrates is disclosed. The ink enables high-volume production of optoelectronic and/or electronic devices using scalable production methods, such as roll-to-roll transfer, fast rolling processes, and the like.

  11. High throughput 3D optical microscopy : from image cytometry to endomicroscopy

    E-Print Network [OSTI]

    Choi, Heejin

    2014-01-01T23:59:59.000Z

    Optical microscopy is an imaging technique that allows morphological mapping of intracellular structures with submicron resolution. More importantly, optical microscopy is a technique that can readily provide images with ...

  12. High-throughput two-hybrid analysis The promise and the peril

    E-Print Network [OSTI]

    Dunham, Maitreya

    , reduction in reagent costs and further refinements of the approach. As throughput escalates, so does use. The first stage is the initial description of a method: the prototype version. Typically. For a large fraction of new technologies, few other examples beyond this proto- type are ever described

  13. High-throughput Characterization of Porous Materials Using Graphics Processing Units

    E-Print Network [OSTI]

    Kim, Jihan

    2013-01-01T23:59:59.000Z

    A.E. ; Purcell, T. Computer Graphics Forum 2007, 26(1), 80-of Porous Materials Using Graphics Processing Units Jihanof Porous Materials Using Graphics Processing Units Jihan

  14. Multi-Channel and Multi-Rate Adaptation for High-Throughput Wireless Networks

    E-Print Network [OSTI]

    Nguyen, Duy Duc

    2012-01-01T23:59:59.000Z

    layer. Unlike wired networks, wireless networks have to deal2 Background Wireless Networks Wireless technology is allWLAN), wireless mesh networks, wireless metropolitan area

  15. Structural inference of native and partially folded RNA by high-throughput contact mapping

    E-Print Network [OSTI]

    Herschlag, Dan

    of the P4­P6 RNA that is stabilized by high concentrations of monovalent salt and whose partial order to the dynamic but otherwise similar molten globule states of proteins. With its applicability to nearly any of large RNA molecules and RNA/protein complexes. hydroxyl radical molten globule Tetrahymena ribozyme two

  16. High throughput parallel backside contacting and periodic texturing for high-efficiency solar cells

    DOE Patents [OSTI]

    Daniel, Claus; Blue, Craig A.; Ott, Ronald D.

    2014-08-19T23:59:59.000Z

    Disclosed are configurations of long-range ordered features of solar cell materials, and methods for forming same. Some features include electrical access openings through a backing layer to a photovoltaic material in the solar cell. Some features include textured features disposed adjacent a surface of a solar cell material. Typically the long-range ordered features are formed by ablating the solar cell material with a laser interference pattern from at least two laser beams.

  17. The Development of a High-throughput Microdroplet Bioreactor Device for Microbial Studies 

    E-Print Network [OSTI]

    Guzman, Adrian

    2012-10-19T23:59:59.000Z

    Current PCR Polymerase Chain Reaction MOS-FET Metal-Oxide-Semiconductor Field-Effect Transistor BSA Bovine Serum Albumin GFP Green Fluorescent Protein RFP Red Fluorescent Protein LED Light Emitting Diode PMT Photomultiplier Tubes...

  18. Lensfree Optical Tomography for High-Throughput 3D Imaging on a Chip

    E-Print Network [OSTI]

    ISIKMAN, SERHAN OMER

    2012-01-01T23:59:59.000Z

    microscope with light-emitting diode illumination. Opt.source such as a light emitting diode (LED). The fundamentalchip microscope, 24 light-emitting diodes (LEDs - each with

  19. HIGH-THROUGHPUT/COMBINATORIAL TECHNIQUES IN HYDROGEN STORAGE MATERIALS R&D WORKSHOP

    E-Print Network [OSTI]

    , academia, and national laboratories. The objectives of this meeting were to: · Assess the potential is solution-based with solids handling similar to proven combinatorial methods. Exploration of new structures-ray scattering (SAXS) to determine pore size (needs development), hydrogen uptake me

  20. An ultra-high throughput mutational spectrometer for human genetic diagnostics

    E-Print Network [OSTI]

    Forest, Craig Richard, 1978-

    2007-01-01T23:59:59.000Z

    Discovering the genetic causes of common diseases may require scanning for mutations in all of the genes in a million people, a significant undertaking. Such discoveries would revolutionize biotechnology, potentially ...

  1. High-throughput, dual probe biological assays based on single molecule detection

    DOE Patents [OSTI]

    Hollars, Christopher W. (Brentwood, CA); Huser, Thomas R. (Livermore, CA); Lane, Stephen M. (Oakland, CA); Balhorn, Rodney L. (Livermore, CA); Bakajin, Olgica (San Leandro, CA); Darrow, Christopher (Pleasanton, CA); Satcher, Jr., Joe H. (Patterson, CA)

    2006-07-11T23:59:59.000Z

    A method and apparatus with the sensitivity to detect and identify single target molecules through the localization of dual, fluorescently labeled probe molecules. This can be accomplished through specific attachment of the taget to a surface or in a two-dimensional (2D) flowing fluid sheet having approximate dimensions of 0.5 .mu.m.times.100 .mu.m.times.100 .mu.m. A device using these methods would have 10.sup.3 10.sup.4 greater throughput than previous one-dimensional (1D) micro-stream devices having 1 .mu.m.sup.3 interrogation volumes and would for the first time allow immuno- and DNA assays at ultra-low (femtomolar) concentrations to be performed in short time periods (.about.10 minutes). The use of novel labels (such as metal or semiconductor nanoparticles) may be incorporated to further extend the sensitivity possibly into the attomolar range.

  2. Encoded hydrogel microparticles for high-throughput molecular diagnostics and personalized medicine

    E-Print Network [OSTI]

    Chapin, Stephen Clifford

    2012-01-01T23:59:59.000Z

    The ability to accurately detect and quantify biological molecules in complex mixtures is crucial in basic research as well as in clinical settings. Advancements in genetic analysis, molecular diagnostics, and patient-tailored ...

  3. SNP Calling Using Genotype Model Selection on High-Throughput Sequencing Data

    E-Print Network [OSTI]

    Murillo, Gabriel Hiroshi

    2012-01-01T23:59:59.000Z

    10, March 2009. [35] Heng Li. Fastq format specification.Accessed: 10/16/2012. [36] Heng Li. Pileup format. http://Ac- cessed: 10/16/2012. [37] Heng Li. Mathematical notes on

  4. Antibody-functionalized nanoporous surfaces enable high throughput specific cell capture

    E-Print Network [OSTI]

    Mittal, Sukant

    2012-01-01T23:59:59.000Z

    Adhesion-based cell capture on surfaces in microfluidic devices forms the basis of numerous biomedical diagnostics and in vitro assays. Solid surface microfluidic platforms have been widely explored for biomedical diagnostics ...

  5. VLPW: The Very Long Packet Window Architecture for High Throughput Network-On-Chip Router Designs

    E-Print Network [OSTI]

    Gu, Haiyin

    2012-10-19T23:59:59.000Z

    -chip routers and the ideal interconnect fabric. To improve throughput, VLPW optimizes Switch Allocation (SA) efficiency. Existing SA normally applies Round-Robin scheduling to arbitrate among the packets targeting the same output port. However, this simple...

  6. irm-EAMS routine measurements: high precision; high accuracy; high throughput

    E-Print Network [OSTI]

    Eurovector EA allows to exchange the reactors separately (and fast). Exchange of the Mg(ClO4)2 water traps and selective CO2 trapping; Improved halide robustness of the combustion reactor using CeO2., Rapid Comm. Mass) inside the EA are exchanged regularly. On the CE-EA, combustion and reduction reactors are always

  7. Advancing the High Throughput Identification of Liver Fibrosis Protein Signatures Using Multiplexed Ion Mobility Spectrometry

    SciTech Connect (OSTI)

    Baker, Erin Shammel; Burnum-Johnson, Kristin E.; Jacobs, Jon M.; Diamond, Deborah L.; Brown, Roslyn N.; Ibrahim, Yehia M.; Orton, Daniel J.; Piehowski, Paul D.; Purdy, David E.; Moore, Ronald J.; Danielson, William F.; Monroe, Matthew E.; Crowell, Kevin L.; Slysz, Gordon W.; Gritsenko, Marina A.; Sandoval, John D.; Lamarche, Brian L.; Matzke, Melissa M.; Webb-Robertson, Bobbie-Jo M.; Simons, Brenna C.; McMahon, Brian J.; Bhattacharya, Renuka; Perkins, James D.; Carithers, Robert L.; Strom, Susan; Self, Steven; Katze, Michael G.; Anderson, Gordon A.; Smith, Richard D.

    2014-04-01T23:59:59.000Z

    Rapid diagnosis of disease states using less invasive, safer, and more clinically acceptable approaches than presently employed is an imperative goal for the field of medicine. While mass spectrometry (MS)-based proteomics approaches have attempted to meet these objectives, challenges such as the enormous dynamic range of protein concentrations in clinically relevant biofluid samples coupled with the need to address human biodiversity have slowed their employment. Herein, we report on the use of a new platform that addresses these challenges by coupling technical advances in rapid gas phase multiplexed ion mobility spectrometry (IMS) separations [1, 2] with liquid chromatography (LC) and MS to dramatically increase measurement sensitivity and throughput, further enabling future MS-based clinical applications. An initial application of the LC-IMS-MS platform for the analysis of blood serum samples from stratified post-liver transplant patients with recurrent fibrosis progression illustrates its potential utility for disease characterization and use in personalized medicine [3, 4].

  8. Inch-Scale High Throughput Metrology of Graphene and Patterned Graphene Oxide

    E-Print Network [OSTI]

    Pleskot, Dennis

    2013-01-01T23:59:59.000Z

    Strength of Monolayer Graphene Science 2008 321, 385-388. 5.Novoselov, K. S. The rise of graphene Nature 2007 6 183-191.A. Thermal properties of graphene and nanostructured carbon

  9. High Throughput Identification, Purification and Structural Characterization of Water Soluble Protein Complexes in Desulfovibrio vulgaris

    SciTech Connect (OSTI)

    Dong,, Ming; Han, Bong-Gyoon; Liu, Hui-Hai; Malik, J.; Geller, Jil; Yang, Li; Choi, M.; Chandonia, John-Marc; Arbelaez, Pablo; Sterling, H. J.; Typke, Dieter; Shatsky, Max; Brenner, Steve; Fisher, Susan; Williams, Evan; Szakal, Evelin; Allen, S.; Hall, S. C.; Hazen, Terry; Witkowska, H. E.; Jin, Jiming; Glaeser, Robert; Biggin, Mark

    2010-05-17T23:59:59.000Z

    Our scheme for the tagless purification of water soluble complexes. 10 g of protein from a crude bacterial extract is first fractionated by ammonium sulfate precipitation and then by a series of chromatographic steps: anion exchange (IEX), hydrophobic interaction (HIC), and finally size exclusion (Gel Filtration). Fractions from the last chromatography step are trypsin digested and peptides labeled with iTRAQ reagents to allow multiplexing and quantitation during mass spectrometric analysis. Elution profiles of identified proteins are then subjected to clustering analysis.

  10. High-throughput genomic analysis of virulence and resistance mechanisms among microbial pathogens

    E-Print Network [OSTI]

    Tewhey, Ryan Stephen

    2012-01-01T23:59:59.000Z

    al. (2010). Evolution of MRSA during hospital transmissionphylogenetic tree CA-MRSA isolates and the reference strainand antibiotic resistance costs by MRSA. The ISME journal 4,

  11. Automated detection and classification of circulating cancer cells via high-throughput microscopy

    E-Print Network [OSTI]

    Agustin, Ramses Martinez

    2007-01-01T23:59:59.000Z

    sample (1/100 dilution in MDA-MB-231) with highest positivesample (1/200 dilution in MDA-MB-231) with highest positivesample (1/200 dilution in MDA-MB-468) with highest positive

  12. High-throughput, single-worm tracking and analysis in Caenorhabditis elegans

    E-Print Network [OSTI]

    Yemini, Eviatar

    2013-01-08T23:59:59.000Z

    Microfluidic Environment. PLoS ONE 3, e2550 (2008). 18. Berri, S., Boyle, J. H., Tassieri, M., Hope, I. A. & Cohen, N. Forward locomotion of the nematode C. elegans is achieved through modulation of a single gait. HFSP J 3, 186–193 (2009). 19. Fang-Yen, C. et...

  13. Hybrid CMOS/Nanodevice Circuits for High Throughput Pattern Matching Applications

    E-Print Network [OSTI]

    Sherwood, Tim

    , Timothy Sherwood2 , and Dmitri B. Strukov1* 1 Electrical and Computer Engineering Department, University Figure 1. Pattern matching with island-type FPGA circuits: (a) general idea, and (b) matching operation addressable memories (T/CAMs) (Fig. 2) [8, 9]. These approaches rely on patterns being loaded into specially

  14. High-throughput experimental and computational tools for exploring immunity and the microbiome

    E-Print Network [OSTI]

    Papa, Eliseo

    2012-01-01T23:59:59.000Z

    Humans live in association with trillions of microbes and yet we know remarkably little about their symbiotic relationship. The role these microorganisms have in humans has been characterized only in the case of few bacteria ...

  15. Polymer microfluidic device for high-throughput single-cell encapsulation, lysis, and biological assay

    E-Print Network [OSTI]

    Brackbill, Timothy Peter

    2012-01-01T23:59:59.000Z

    rheology through microfluidics,” Advanced Materials, vol.Berthier and P. Silberzan, Microfluidics for Biotechnology.A. P. Lee, “Droplet microfluidics,” Lab on a Chip, vol. 8,

  16. High-Throughput 3D Structural Homology Detection via NMR Resonance Christopher James Langmead

    E-Print Network [OSTI]

    Richardson, David

    is the number of residues in the tar- get protein and c is the maximum edge weight in an integer- weighted for two dissimilar amino acid sequences to fold to the "same" ter- tiary structure. For example, the RMSD

  17. A Warm Near-Infrared High-Resolution Spectrograph with Very High Throughput (WINERED)

    E-Print Network [OSTI]

    Kondo, Sohei; Kobayashi, Naoto; Yasui, Chikako; Mito, Hiroyuki; Fukue, Kei; Nakanishi, Kenshi; Kawanishi, Takafumi; Nakaoka, Tetsuya; Otsubo, Shogo; Kinoshita, Masaomi; Kitano, Ayaka; Hamano, Satoshi; Mizumoto, Misaki; Yamamoto, Ryo; Izumi, Natsuko; Matsunaga, Noriyuki; Kawakita, Hideyo

    2015-01-01T23:59:59.000Z

    WINERED is a newly built high-efficiency (throughput$ > 25-30\\%$) and high-resolution spectrograph customized for short NIR bands at 0.9-1.35 ${\\rm \\mu}$m. WINERED is equipped with ambient temperature optics and a cryogenic camera using a 1.7 ${\\rm \\mu}$m cut-off HgCdTe HAWAII-2RG array detector. WINERED has two grating modes: one with a conventional reflective echelle grating (R$\\sim$28,300), which covers 0.9-1.35 $\\mu$m simultaneously, the other with ZnSe or ZnS immersion grating (R$\\sim$100,000). We have completed the development of WINERED except for the immersion grating, and started engineering and science observations at the Nasmyth platform of the 1.3 m Araki Telescope at Koyama Astronomical Observatory of Kyoto-Sangyo University in Japan. We confirmed that the spectral resolution ($R\\sim$ 28,300) and the throughput ($>$ 40\\% w/o telescope/atmosphere/array QE) meet our specifications. We measured ambient thermal backgrounds (e.g., 0.06 ${\\rm [e^{-}/sec/pixel]}$ at 287 K), which are roughly consistent ...

  18. The First Extrasolar Planet Discovered with a New Generation High Throughput Doppler Instrument

    E-Print Network [OSTI]

    Complutense de Madrid, Universidad

    was confirmed by radial velocity observations with the ET at the KPNO 2.1 m tele- scope and also at the 9 m is an effective method for planet detection. In addition, the ET concept is adaptable to multiple-object Doppler activity as the cause of the radial velocity variability. Our photometric observations rule out transits

  19. High-throughput Microfluidics and Ultrafast Optics for in Vivo Compound/Genetic Discoveries

    E-Print Network [OSTI]

    Rohde, Christopher Benjamin

    Therapeutic treatment of spinal cord injuries, brain trauma, stroke, and neurodegenerative diseases will greatly benefit from the discovery of compounds that enhance neuronal regeneration following injury. We previously ...

  20. alphascreen high-throughput assay: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: provided a blueprint of the DNA present in each human cell, genomics research is now focusing on the study) Hybridizing these primers with the genomic...

  1. automated high-throughput assay: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: provided a blueprint of the DNA present in each human cell, genomics research is now focusing on the study) Hybridizing these primers with the genomic...

  2. Identification and correction of systematic error in high-throughput sequence data

    E-Print Network [OSTI]

    Meacham, Frazer; Boffelli, Dario; Dhahbi, Joseph; Martin, David IK; Singer, Meromit; Pachter, Lior

    2011-01-01T23:59:59.000Z

    The reads were mapped with Bowtie [10] allowing up to twothe refer- ence genome with Bowtie and refined our analysisto the virus genome using Bowtie, obtaining 382.2Ś coverage

  3. Novel SNP Discovery in African Buffalo, Syncerus caffer, Using High-Throughput Sequencing

    E-Print Network [OSTI]

    Steve Kemp

    and Bowtie software packages. A mean depth of 2.76 coverage over the mapped regions was obtained. Btau4 gene annotation was added to all SNPs identified within gene regions. Bowtie and BWA identified a maximum of 2 SNPs, 43­54% of the Bowtie SNPs and 57­58% of the BWA SNPs were confirmed as polymorphic. dN/dS ratios

  4. Characterization and High Throughput Analysis of Metal Hydrides for Hydrogen Storage

    E-Print Network [OSTI]

    Barcelo, Steven James

    2009-01-01T23:59:59.000Z

    Hydrides for Energy Storage. A.F. Andresen and A.J. Maeland,Metal Hydrides for Hydrogen Storage by Steven James BarceloMetal Hydrides for Hydrogen Storage by Steven James Barcelo

  5. High Throughput Ab initio Modeling of Charge Transport for Bio-Molecular-Electronics

    E-Print Network [OSTI]

    Bruque, Nicolas A.

    2009-01-01T23:59:59.000Z

    DNA-Based Molecular Electronics. vol. 725. New York: AIP,Heath, “Whence molecular electronics? ” Science, vol. 306,model,” J. Computational Electronics, vol. 6, no. 4, pp.

  6. ORIGINAL PAPER The RABiT: high-throughput technology for assessing global DSB

    E-Print Network [OSTI]

    Brenner, David Jonathan

    . Turner · P. Sharma · J. R. Perrier · A. Bertucci · L. Smilenov · G. Johnson · M. Taveras · D. J. Brenner, and it has a H. C. Turner (&) Á P. Sharma Á J. R. Perrier Á A. Bertucci Á L. Smilenov Á G. Johnson Á M

  7. Analysis of High-Throughput Sequencing and Annotation Strategies for Phage Genomes

    E-Print Network [OSTI]

    Chisholm, Sallie (Penny)

    Background: Bacterial viruses (phages) play a critical role in shaping microbial populations as they influence both host mortality and horizontal gene transfer. As such, they have a significant impact on local and global ...

  8. High throughput lessons from the LHC experience.Johnston.TNC2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tier 1 centers into their computing clusters at universities ("Tier 2" centers) for analysis. 2 The management of this data - from CERN (Tier 0) to Tier 1 data center to Tier 2...

  9. SNP Calling Using Genotype Model Selection on High-Throughput Sequencing Data

    E-Print Network [OSTI]

    Murillo, Gabriel Hiroshi

    2012-01-01T23:59:59.000Z

    II [44] Atlas-SNP2 [59] inGAP [54] SAMtools [39] VarScan [and Stephan C. Schuster. inGAP: an in- tegrated next-

  10. Ultra-high-aspect-ratio nanofluidic channels for high-throughput biological applications

    E-Print Network [OSTI]

    Mao, Pan

    2009-01-01T23:59:59.000Z

    The development of micro/nanofluidics is expected to be the enabling technology for sample preparation of proteomic biosamples, which has been the bottleneck in proteomics. Most microfabricated nanofluidic channels, such ...

  11. Biochemical & Thermochemical High Throughput Characterization of Feedstocks Presentation for BETO 2015 Project Peer Review

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureCommentsEnergyand SustainedBio-Oil Deployment in the Home Heating 20

  12. Biochemical & Thermochemical High Throughput Characterization of Feedstocks for BETO 2015 Project Peer Review

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureCommentsEnergyand SustainedBio-Oil Deployment in the Home Heating 20

  13. Bayesian Model Selection for High-dimensional High-throughput Data

    E-Print Network [OSTI]

    Joshi, Adarsh

    2012-07-16T23:59:59.000Z

    LIST OF TABLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . x LIST OF FIGURES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi CHAPTER I INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . 1 II... BAYESIAN HYPOTHESIS TESTING USING TEST STATISTICS 7 2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.3 Bayes? factors based on test statistics: testing...

  14. Polymer microfluidic device for high-throughput single-cell encapsulation, lysis, and biological assay

    E-Print Network [OSTI]

    Brackbill, Timothy Peter

    2012-01-01T23:59:59.000Z

    is a valid assumption. The viscosity of the oil was alsoassumption is often wrong, be- Table 4.2: Summary of measured viscosities from capillary measurement. Oil/

  15. High-throughput Isolation and Characterization of Untagged Membrane Protein Complexes: Outer Membrane Complexes

    E-Print Network [OSTI]

    , Evelin D. Szakal,§, Haichuan Liu,§ Steven C. Hall,§ Susan J. Fisher,,§ Bonita R. Lam, Mary E. Singer, Jil

  16. High-throughput multispot single-molecule spectroscopy Ryan A. Colyera*

    E-Print Network [OSTI]

    Michalet, Xavier

    an approach to multiple spot generation which is flexible, user-friendly, and rapidly adjustable so-spot generation methods, such as the use of microlens arrays with a static configuration 3 , 2D fiber arrays (e on silicon (LCOS) devices with computationally complex pattern generation 4, 5 . However, we desire

  17. Estimating enrichment of repetitive elements from high-throughput sequence data

    E-Print Network [OSTI]

    Luquette, Lovelace J.

    We describe computational methods for analysis of repetitive elements from short-read sequencing data, and apply them to study histone modifications associated with the repetitive elements in human and mouse cells. Our ...

  18. High throughput lessons from the LHC experience.Johnston.TNC2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm) Harmonicbet WhenHiggs BosonAccurate knowledgeHighHighhigh

  19. High-Throughput, High-Precision Hot Testing Tool for High-Brightness

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking of Blythe Solar PowerCommercial Cold Climate HeatEnergy

  20. High-Throughput/Combinatorial Techniques in Hydrogen Storage Materials R&D

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking of Blythe Solar PowerCommercial Cold Climate HeatEnergy| Department of

  1. Algorithms and tools for high-throughput geometry-based analysis of

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem NotEnergy,ARMForms About BecomeTechnologies | Blandine Jerome

  2. High-Throughput Methodology for Discovery of Metal-Organic Frameworks with

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a rDepartment ofofa High Binding

  3. High-Throughput Program for the Discovery of NOx Reduction Catalysts |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a rDepartment ofofa High

  4. High-Throughput/Combinatorial Techniques in Hydrogen Storage Materials R&D

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a rDepartment ofofa(presentation)

  5. Process of Integrating Screening and Detailed Risk-based Modeling Analyses to Ensure Consistent and Scientifically Defensible Results

    SciTech Connect (OSTI)

    Buck, John W.; McDonald, John P.; Taira, Randal Y.

    2002-11-01T23:59:59.000Z

    To support cleanup and closure of these tanks, modeling is performed to understand and predict potential impacts to human health and the environment. Pacific Northwest National Laboratory developed a screening tool for the United States Department of Energy, Office of River Protection that estimates the long-term human health risk, from a strategic planning perspective, posed by potential tank releases to the environment. This tool is being conditioned to more detailed model analyses to ensure consistency between studies and to provide scientific defensibility. Once the conditioning is complete, the system will be used to screen alternative cleanup and closure strategies. The integration of screening and detailed models provides consistent analyses, efficiencies in resources, and positive feedback between the various modeling groups. This approach of conditioning a screening methodology to more detailed analyses provides decision-makers with timely and defensible information and increases confidence in the results on the part of clients, regulators, and stakeholders.

  6. Impact of Screening on Behavior During Storage and Cost of Ground Small-Diameter Pine Trees: A Case Study

    SciTech Connect (OSTI)

    Erin Searcy; Brad D Blackwelder; Mark E Delwiche; Allison E Ray; Kevin L Kenney

    2011-10-01T23:59:59.000Z

    Whole comminuted trees are known to self-heat and undergo quality changes during storage. Trommel screening after grinding is a process that removes fines from the screened material and removes a large proportion of high-ash, high-nutrient material. In this study, the trade-off between an increase in preprocessing cost from trommel screening and an increase in quality of the screened material was examined. Fresh lodgepole pine (Pinus contorta) was comminuted using a drum grinder with a 10-cm screen, and the resulting material was distributed into separate fines and overs piles. A third pile of unscreened material, the unsorted pile, was also examined. The three piles exhibited different characteristics during a 6-week storage period. The overs pile was much slower to heat. The overs pile reached a maximum temperature of 56.88 degrees C, which was lower than the maximum reached by the other two piles (65.98 degrees C and 63.48 degrees C for the unsorted and fines, respectively). The overs also cooled faster and dried to a more uniform moisture content and had a lower ash content than the other two piles. Both piles of sorted material exhibited improved airflow and more drying than the unsorted material. Looking at supply system costs from preprocessing through in-feed into thermochemical conversion, this study found that trommel screening reduced system costs by over $3.50 per dry matter ton and stabilized material during storage.

  7. Screening analysis of solar thermochemical hydrogen concepts.

    SciTech Connect (OSTI)

    Diver, Richard B., Jr.; Kolb, Gregory J.

    2008-03-01T23:59:59.000Z

    A screening analysis was performed to identify concentrating solar power (CSP) concepts that produce hydrogen with the highest efficiency. Several CSP concepts were identified that have the potential to be much more efficient than today's low-temperature electrolysis technology. They combine a central receiver or dish with either a thermochemical cycle or high-temperature electrolyzer that operate at temperatures >600 C. The solar-to-hydrogen efficiencies of the best central receiver concepts exceed 20%, significantly better than the 14% value predicted for low-temperature electrolysis.

  8. Electron screening effect on stellar thermonuclear fusion

    E-Print Network [OSTI]

    Potekhin, A Y

    2013-01-01T23:59:59.000Z

    We study the impact of plasma correlation effects on nonresonant thermonuclear reactions for various stellar objects, namely in the liquid envelopes of neutron stars, and the interiors of white dwarfs, low-mass stars, and substellar objects. We examine in particular the effect of electron screening on the enhancement of thermonuclear reactions in dense plasmas within and beyond the linear mixing rule approximation as well as the corrections due to quantum effects at high density. In addition, we examine some recent unconventional (Yukawa-potential and "quantum-tail") theoretical results on stellar thermonuclear fusions and show that these scenarios do not apply to stellar conditions.

  9. National Supplemental Screening Program | Department of Energy

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed offOCHCO2:Introduction toManagement ofConverDyn NOPRNancyNational Supplemental Screening Program

  10. BCHP Screening Tool | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof EnergyInnovation in Carbon CaptureAtria PowerAxeonBCHP Screening Tool Jump to:

  11. Strong plasma screening in thermonuclear reactions: Electron drop model

    E-Print Network [OSTI]

    Kravchuk, P A

    2014-01-01T23:59:59.000Z

    We analyze enhancement of thermonuclear fusion reactions due to strong plasma screening in dense matter using a simple electron drop model. The model assumes fusion in a potential that is screened by an effective electron cloud around colliding nuclei (extended Salpeter ion-sphere model). We calculate the mean field screened Coulomb potentials for atomic nuclei with equal and nonequal charges, appropriate astrophysical S factors, and enhancement factors of reaction rates. As a byproduct, we study analytic behavior of the screening potential at small separations between the reactants. In this model, astrophysical S factors depend not only on nuclear physics but on plasma screening as well. The enhancement factors are in good agreement with calculations by other methods. This allows us to formulate the combined, pure analytic model of strong plasma screening in thermonuclear reactions. The results can be useful for simulating nuclear burning in white dwarfs and neutron stars.

  12. Strong plasma screening in thermonuclear reactions: Electron drop model

    E-Print Network [OSTI]

    P. A. Kravchuk; D. G. Yakovlev

    2014-01-11T23:59:59.000Z

    We analyze enhancement of thermonuclear fusion reactions due to strong plasma screening in dense matter using a simple electron drop model. The model assumes fusion in a potential that is screened by an effective electron cloud around colliding nuclei (extended Salpeter ion-sphere model). We calculate the mean field screened Coulomb potentials for atomic nuclei with equal and nonequal charges, appropriate astrophysical S factors, and enhancement factors of reaction rates. As a byproduct, we study analytic behavior of the screening potential at small separations between the reactants. In this model, astrophysical S factors depend not only on nuclear physics but on plasma screening as well. The enhancement factors are in good agreement with calculations by other methods. This allows us to formulate the combined, pure analytic model of strong plasma screening in thermonuclear reactions. The results can be useful for simulating nuclear burning in white dwarfs and neutron stars.

  13. Non-equilibrium thermodynamics of gravitational screens

    E-Print Network [OSTI]

    Laurent Freidel; Yuki Yokokura

    2014-05-19T23:59:59.000Z

    We study the Einstein gravity equations projected on a timelike surface, which represents the time evolution of what we call a gravitational screen. We show that such a screen possesses a surface tension and an internal energy, and that the Einstein equations reduce to the thermodynamic equations of a viscous bubble. We also provide a complete dictionary between gravitational and thermodynamical variables. In the non-viscous cases there are three thermodynamic equations which characterise a bubble dynamics: These are the first law, the Marangoni flow equation and the Young-Laplace equation. In all three equations the surface tension plays a central role: In the first law it appears as a work term per unit area, in the Marangoni flow its gradient drives a force, and in the Young-Laplace equation it contributes to a pressure proportional to the surface curvature. The gravity equations appear as a natural generalization of these bubble equations when the bubble itself is viscous and dynamical. In particular, it shows that the mechanism of entropy production for the viscous bubble is mapped onto the production of gravitational waves. We also review the relationship between surface tension and temperature, and discuss the usual black-hole thermodynamics from this point of view.

  14. Final Report - Phylogenomic tools and web resources for the Systems Biology Knowledgebase

    SciTech Connect (OSTI)

    Sjolander, Kimmen

    2014-11-07T23:59:59.000Z

    The major advance during this last reporting period (8/15/12 to present) is our release of data on the PhyloFacts website: phylogenetic trees, multiple sequence alignments and other data for protein families are now available for download from http://phylogenomics.berkeley.edu/data/. This project as a whole aimed to develop high-throughput functional annotation systems that exploit information from protein 3D structure and evolution to provide highly precise inferences of various aspects of gene function, including molecular function, biological process, pathway association, Pfam domains, cellular localization and so on. We accomplished these aims by developing and testing different systems on a database of protein family trees: the PhyloFacts Phylogenomic Encyclopedia (at http://phylogenomics.berkeley.edu/phylofacts/ ).

  15. active screen plasma: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    reactions: Electron drop model CERN Preprints Summary: We analyze enhancement of thermonuclear fusion reactions due to strong plasma screening in dense matter using a...

  16. Yakima River Basin Phase II Fish Screen Evaluations, 2001.

    SciTech Connect (OSTI)

    Carter, J.A.; McMichael, Geoffrey A.; Chamness, M.A.

    2002-01-01T23:59:59.000Z

    In the summer and fall of 2001 the Pacific Northwest National Laboratory (PNNL) evaluated 23 Phase II fish screen sites in the Yakima River Basin as part of a multi-year study for the Bonneville Power Administration (BPA) on the effectiveness of fish screening devices. Data were collected to determine if velocities in front of the screens and in the bypasses met current National Marine Fisheries Service (NMFS) criteria to promote safe and timely fish passage and whether bypass outfall conditions allowed fish to safely return to the river. Based on our studies in 2001, we concluded that: in general, water velocity conditions at the screen sites met fish passage criteria set forth by the NMFS; most facilities efficiently protected juvenile fish from entrainment, impingement, or migration delay; automated cleaning brushes generally functioned properly; chains and other moving parts were well greased and operative; and removal of sediment build-up and accumulated leafy and woody debris are areas that continue to improve. Continued periodic screen evaluations will increase the effectiveness of screen operation and maintenance practices by confirming the effectiveness (or ineffectiveness) of screen operating procedures at individual sites. Where procedures are being followed and problems still occur, evaluation results can be used to suggest means to better protect fish at screening facilities. There has been a progressive improvement in the maintenance and effectiveness of fish screen facilities in the Yakima River Basin during the last several years, in part, as a result of regular screen evaluations and the rapid feedback of information necessary to improve operations and design of these important fish protection devices. Continued periodic screen evaluations will increase the effectiveness of screen operation and maintenance practices by confirming the effectiveness (or ineffectiveness) of screen operating procedures at individual sites. Where procedures are being followed and problems still occur, evaluation results can be used to suggest means to better protect fish at screening facilities. There has been a progressive improvement in the maintenance and effectiveness of fish screen facilities in the Yakima River Basin during the last several years, in part, as a result of regular screen evaluations and the rapid feedback of information necessary to improve operations and design of these important fish protection devices.

  17. Roof screening for underground coal mines: recent developments

    SciTech Connect (OSTI)

    Compton, C.S.; Gallagher, S.; Molinda, G.M.; Mark, C.; Wilson, G.

    2008-06-15T23:59:59.000Z

    The use of screens to control falls of the immediate roof or roof skin (that is between the installed primary and secondary roof supports) is described. 5 figs.

  18. Combining in vivo and in silico screening for protein stability

    E-Print Network [OSTI]

    Barakat, Nora Hisham

    2007-01-01T23:59:59.000Z

    Implications for the Protein Folding Code". Biochemistry 44(Proteolytic selection for protein folding using filamentousin vivo screening for protein folding and increased protein

  19. abuse screening tool: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (HPV Druzdzel, Marek J. 3 The Feasibility of Tablet Computer Screening for Opioid Abuse in the Emergency Department University of California eScholarship Repository...

  20. abuse screening tools: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (HPV Druzdzel, Marek J. 3 The Feasibility of Tablet Computer Screening for Opioid Abuse in the Emergency Department University of California eScholarship Repository...

  1. assessing screening practices: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Katherine B. Gibney; Karin Leder; Daniel P. Obrien; Caroline Marshall; Beverley-ann Biggs 16 The Pittsburgh Cervical Cancer Screening Model A Risk Assessment Tool Computer...

  2. Coal storage hopper with vibrating-screen agitator

    DOE Patents [OSTI]

    Daw, C.S.; Lackey, M.E.; Sy, R.L.

    1982-04-27T23:59:59.000Z

    The present invention is directed to a vibrating screen agitator in a coal storage hopper for assuring the uniform feed of coal having sufficient moisture content to effect agglomeration and bridging thereof in the coal hopper from the latter onto a conveyer mechanism. The vibrating scrren agitator is provided by a plurality of transversely oriented and vertically spaced apart screens in the storage hopper with a plurality of vertically oriented rods attached to the screens. The rods are vibrated to effect the vibration of the screens and the breaking up of agglomerates in the coal which might impede the uniform flow of the coal from the hopper onto a conveyer.

  3. FIELD SCREENING FOR HALOGENATED VOLATILE ORGANIC COMPOUNDS

    SciTech Connect (OSTI)

    John F. Schabron; Joseph F. Rovani, Jr.; Theresa M. Bomstad

    2003-07-01T23:59:59.000Z

    Western Research Institute (WRI) is continuing work toward the development of new screening methodology and a test kit to measure halogenated volatile organic compounds (VOCs) in the field. Heated diode and corona discharge sensors are commonly used to detect leaks of refrigerants from air conditioners, freezers, and refrigerators. They are both selective to the presence of halogens. In prior work, the devices were tested for response to carbon tetrachloride, heptane, toluene, and water vapors. In the current work, sensor response was evaluated with sixteen halogenated VOCs relative to carbon tetrachloride. The results show that the response of the various chlorinated VOCs is within an order of magnitude of the response to carbon tetrachloride for each of the sensors. Thus, for field screening a single response factor can be used. Both types of leak detectors are being further modified to provide an on-board LCD signal readout, which is related to VOC concentration. The units will be fully portable and will operate with 115-V line or battery power. Signal background, noise level, and response data on the Bacharach heated diode detector and the TIF corona discharge detector show that when the response curves are plotted against the log of concentration, the plot is linear to the upper limit for the particular unit, with some curvature at lower levels. When response is plotted directly against concentration, the response is linear at the low end and is curved at the high end. The dynamic ranges for carbon tetrachloride of the two devices from the lower detection limit (S/N=2) to signal saturation are 4-850 vapor parts per million (vppm) for the corona discharge unit and 0.01-70 vppm for the heated diode unit. Additional circuit modifications are being made to lower the detection limit and increase the dynamic response range of the corona discharge unit. The results indicate that both devices show potential utility for future analytical method development work toward the goal of developing a portable test kit for screening halogenated VOCs in the field.

  4. Performance assessment of CsI(Tl) screens on various substrates for X-ray imaging

    E-Print Network [OSTI]

    Feng, Zhaodong; Zhang, Hongkai; Zhao, Bozhen; Qin, Xiubo; Wei, Cunfeng; Liu, Yu; Wei, Long

    2015-01-01T23:59:59.000Z

    Thallium-doped cesium iodide (CsI(Tl)) screens are widely used in X-ray imaging devices because of the columnar structure of CsI(Tl) layer, but few reports focus on the optical role of the substrate in the screen system. In this paper, four substrates including fused silica (SiO2), silver-film coated SiO2, graphite (C) and fiber optic plate (FOP) are used to fabricate CsI(Tl) screens by thermal evaporation. Their imaging performance is evaluated by relative light output (RLO), modulation transfer function (MTF), normalized noise power spectrum (NNPS) and noise equivalent quanta (NEQ). The results reveal that although CsI(Tl) film on graphite plate yields images with the lowest light output, it presents relatively higher spatial resolution and better signal-to-noise characteristics. However, films on SiO2 plate obtain low MTF but high NNPS curves, whether or not coated with silver film. Furthermore, scintillation screens on FOP have bright images with low NNPS and high NEQ, but have the lowest MTF. By controll...

  5. Screened thermonuclear reactions and predictive stellar evolution of detached double-lined eclipsing binaries

    E-Print Network [OSTI]

    Theodore Liolios; Theocharis Kosmas

    2005-07-06T23:59:59.000Z

    The low energy fusion cross sections of charged-particle nuclear reactions (and the respective reaction rates) in stellar plasmas are enhanced due to plasma screening effects. We study the impact of those effects on predictive stellar evolution simulations for detached double-lined eclipsing binaries. We follow the evolution of binary systems (pre-main sequence or main sequence stars) with precisely determined radii and masses from 1.1Mo to 23Mo (from their birth until their present state). The results indicate that all the discrepancies between the screened and unscreened models (in terms of luminosity, stellar radius, and effective temperature) are within the observational uncertainties. Moreover, no nucleosynthetic or compositional variation was found due to screening corrections. Therefore all thermonuclear screening effects on the charged-particle nuclear reactions that occur in the binary stars considered in this work (from their birth until their present state) can be totally disregarded. In other words, all relevant charged-particle nuclear reactions can be safely assumed to take place in a vacuum, thus simplifying and accelerating the simulation processes.

  6. Apparatus and method for radioactive waste screening

    DOE Patents [OSTI]

    Akers, Douglas W.; Roybal, Lyle G.; Salomon, Hopi; Williams, Charles Leroy

    2012-09-04T23:59:59.000Z

    An apparatus and method relating to screening radioactive waste are disclosed for ensuring that at least one calculated parameter for the measurement data of a sample falls within a range between an upper limit and a lower limit prior to the sample being packaged for disposal. The apparatus includes a radiation detector configured for detecting radioactivity and radionuclide content of the of the sample of radioactive waste and generating measurement data in response thereto, and a collimator including at least one aperture to direct a field of view of the radiation detector. The method includes measuring a radioactive content of a sample, and calculating one or more parameters from the radioactive content of the sample.

  7. Maximum screening fields of superconducting multilayer structures

    E-Print Network [OSTI]

    Gurevich, Alex

    2015-01-01T23:59:59.000Z

    It is shown that a multilayer comprised of alternating thin superconducting and insulating layers on a thick substrate can fully screen the applied magnetic field exceeding the superheating fields $H_s$ of both the superconducting layers and the substrate, the maximum Meissner field is achieved at an optimum multilayer thickness. For instance, a dirty layer of thickness $\\sim 0.1\\; \\mu$m at the Nb surface could increase $H_s\\simeq 240$ mT of a clean Nb up to $H_s\\simeq 290$ mT. Optimized multilayers of Nb$_3$Sn, NbN, some of the iron pnictides, or alloyed Nb deposited onto the surface of the Nb resonator cavities could potentially double the rf breakdown field, pushing the peak accelerating electric fields above 100 MV/m while protecting the cavity from dendritic thermomagnetic avalanches caused by local penetration of vortices.

  8. Results of the material screening program of the NEXT experiment

    E-Print Network [OSTI]

    Dafni, T; Bandac, I; Bettini, A; Borges, F I G M; Camargo, M; Carcel, S; Cebrian, S; Cervera, A; Conde, C A N; Diaz, J; Esteve, R; Fernandes, L M P; Fernandez, M; Ferrario, P; Ferreira, A L; Freitas, E D C; Gehman, V M; Goldschmidt, A; Gomez, H; Gomez-Cadenas, J J; Gonzalez-Diaz, D; Gutierrez, R M; Hauptman, J; Morata, J A Hernando; Herrera, D C; Iguaz, F J; Irastorza, I G; Labarga, L; Laing, A; Liubarsky, I; Lorca, D; Losada, M; Luzon, G; Mari, A; Martin-Albo, J; Martinez, A; Martinez-Lema, G; Miller, T; Monrabal, F; Monserrate, M; Monteiro, C M B; Mora, F J; Moutinho, L M; Vidal, J Munoz; Nebot-Guinot, M; Nygren, D; Oliveira, C A B; Perez, J; Aparicio, J L Perez; Renner, J; Ripoll, L; Rodriguez, A; Rodriguez, J; Santos, F P; Santos, J M F dos; Segui, L; Serra, L; Shuman, D; Simon, A; Sofka, C; Sorel, M; Toledo, J F; Torrent, J; Tsamalaidze, Z; Veloso, J F C A; Villar, J A; Webb, R C; White, J T; Yahlali, N

    2014-01-01T23:59:59.000Z

    The 'Neutrino Experiment with a Xenon TPC (NEXT)', intended to investigate neutrinoless double beta decay, requires extremely low background levels. An extensive material screening and selection process to assess the radioactivity of components is underway combining several techniques, including germanium gamma-ray spectrometry performed at the Canfranc Underground Laboratory; recent results of this material screening program are presented here.

  9. Simplex-based screening designs for estimating metamodels

    E-Print Network [OSTI]

    Boyer, Edmond

    by one factor. In this article, we introduce a non-OAT simplex-based design for the elementary effectsSimplex-based screening designs for estimating metamodels Gilles Pujol Ecole Nationale Superieure experiments, sensitivity analysis, factor screening, elementary effect, simplex design 1 Introduction

  10. allergy screen test: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    allergy screen test First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 LATEX ALLERGY SCREENING...

  11. Environmental Screening and Evaluation of Energy-using Products

    E-Print Network [OSTI]

    .2 ENVIRONMENTAL SCREENING BASED ON THE ECOINVENT DATABASE 40 5.3 ECOLABEL REQUIREMENTS 48 5.4 TECHNOLOGY.2 ENVIRONMENTAL SCREENING BASED ON THE ECOINVENT DATABASE 58 6.3 ECOLABEL REQUIREMENTS 61 6.4 TECHNOLOGY ON THE ECOINVENT DATABASE 73 8.3 ECOLABEL REQUIREMENTS 73 8.4 TECHNOLOGY AND MARKET TRENDS 73 8.5 CONCLUSION 74 8

  12. Building up the screening below the femtosecond scale

    E-Print Network [OSTI]

    Muińo, Ricardo Díez

    Building up the screening below the femtosecond scale A. Borisov a;b D. S#19;anchez-Portal b;c R. D that the screening is built-up locally on a time scale well below the femtosecond for typical metallic densities. At this ultrashort time scale, the time evolution is not a#11;ected by the cluster boundary conditions, and our

  13. Pre-Employment Screening: How New EEOC Guidance Affects

    E-Print Network [OSTI]

    Weaver, Harold A. "Hal"

    Pre-Employment Screening: How New EEOC Guidance Affects Criminal Background Checks & Potentially Increases Employer Risks An HRWebAdvisor Webinar by Mark A. de Bernardo, Esq. Jackson Lewis LLP #12;HRWebAdvisor Webinar: Pre-Employment Screening 2 Our webinars are designed to be accurate

  14. Conservation Screening Curves to Compare Efficiency Investments to Power Plants

    E-Print Network [OSTI]

    methodology to compare supply and demand-side resources. The screening curve approach supplements with load curve approach supplements with load shape information the data contained in a supply curve of conservedLBL-27286 Conservation Screening Curves to Compare Efficiency Investments to Power Plants Jonathan

  15. Results of the material screening program of the NEXT experiment

    E-Print Network [OSTI]

    T. Dafni; V. Alvarez; I. Bandac; A. Bettini; F. I. G. M. Borges; M. Camargo; S. Carcel; S. Cebrian; A. Cervera; C. A. N. Conde; J. Diaz; R. Esteve; L. M. P. Fernandes; M. Fernandez; P. Ferrario; A. L. Ferreira; E. D. C. Freitas; V. M. Gehman; A. Goldschmidt; H. Gomez; J. J. Gomez-Cadenas; D. Gonzalez-Diaz; R. M. Gutierrez; J. Hauptman; J. A. Hernando Morata; D. C. Herrera; F. J. Iguaz; I. G. Irastorza; L. Labarga; A. Laing; I. Liubarsky; D. Lorca; M. Losada; G. Luzon; A. Mari; J. Martin-Albo; A. Martinez; G. Martinez-Lema; T. Miller; F. Monrabal; M. Monserrate; C. M. B. Monteiro; F. J. Mora; L. M. Moutinho; J. Munoz Vidal; M. Nebot-Guinot; D. Nygren; C. A. B. Oliveira; J. Perez; J. L. Perez Aparicio; J. Renner; L. Ripoll; A. Rodriguez; J. Rodriguez; F. P. Santos; J. M. F. dos Santos; L. Segui; L. Serra; D. Shuman; A. Simon; C. Sofka; M. Sorel; J. F. Toledo; J. Torrent; Z. Tsamalaidze; J. F. C. A. Veloso; J. A. Villar; R. C. Webb; J. T. White; N. Yahlali

    2014-11-05T23:59:59.000Z

    The 'Neutrino Experiment with a Xenon TPC (NEXT)', intended to investigate neutrinoless double beta decay, requires extremely low background levels. An extensive material screening and selection process to assess the radioactivity of components is underway combining several techniques, including germanium gamma-ray spectrometry performed at the Canfranc Underground Laboratory; recent results of this material screening program are presented here.

  16. Lead Screening for NH Soils: Minimizing Health Risks

    E-Print Network [OSTI]

    New Hampshire, University of

    family. On your soil test report, if the lead screening levels are elevated, you will receive in populated areas include the use of lead paint around homes (pre- 1970s), the use of lead-arsenate for pest does a "lead screening" test that indicates whether or not lead could pose a health risk for your

  17. METHODS AND APPLICATIONS White and green screening with circular

    E-Print Network [OSTI]

    Regan, Lynne

    METHODS AND APPLICATIONS White and green screening with circular polymerase extension cloning frustrating. Here, we present a stream- lined cloning strategy that incorporates a powerful white and green, or substitution libraries. Keywords: GFP; blue-white screening; circular polymerase extension cloning; Phusion

  18. A Personal Touch -Recognizing Users Based on Touch Screen Behavior

    E-Print Network [OSTI]

    of user interaction of personal smart phones and touch screen based devices are often shared among severalA Personal Touch - Recognizing Users Based on Touch Screen Behavior Sarah Martina Kolly Computer, there are still many open research questions concerning the basic input properties of these devices. We performed

  19. High-Solids Enzymatic Saccharification Screening Method for Lignocellulosic Biomass (Poster)

    SciTech Connect (OSTI)

    Roche, C. M.; Stickel, J. J.

    2009-05-01T23:59:59.000Z

    The ability to screen new biomass pretreatments and advanced enzyme systems at process-relevant conditions is key to developing economically viable lignocellulosic ethanol. While much research is being invested in developing pretreatment technologies and enzyme systems that will more efficiently convert cellulosic biomass to sugars, the current standard reactor vessel, a shake flask, that is used for screening enzymatic saccharification of cellulosic biomass is inadequate at high-solids conditions. Shake flasks do not provide adequate mixing at high solids conditions. In this work, a roller bottle reactor was identified as a small-scale high-solids saccharification reaction vessel, and a method was developed for use in screening both pretreated biomass and enzyme systems at process-relevant conditions. This new method addresses mixing issues observed in high-solids saccharifications. In addition, yield calculations from sugar concentrations on a mass basis were used to account for the two-phase nature of the saccharification slurry, which eliminates discontinuities in comparing high-solids to low-solids saccharifications that occur when using concentrations on a volume basis. The roller bottle reactors out-performed the shake flasks by 5% for an initial insoluble solids loading of 15% and 140% for an initial soluble solids loading of 30%. The reactor system and method was compared at bench and floor scales and determined to be scalable for initial insoluble solids loading in the range of 15% to 30%. Pretreatment and enzyme screening results indicate that mid severity pretreated biomass is more digestible than the low and high severity biomass and GC220 is a superior enzyme to Spezyme CP.

  20. One piece microwave container screens for electrodeless lamps

    DOE Patents [OSTI]

    Turner, Brian (Myersville, MD); Ury, Michael (Bethesda, MD)

    1998-01-01T23:59:59.000Z

    A microwave powered electrodeless lamp includes an improved screen unit having mesh and solid sections with an internal reflector to reflect light into a light-transmitting chamber defined in the lamp microwave cavity by the reflector and the mesh section. A discharge envelope of a bulb is disposed in the light-transmitting chamber. Light emitted from the envelope is prevented by the reflector from entering the cavity portion bounded by the solid section of the screen. Replacing mesh material by solid metal material as part of the screen unit significantly reduces leakage of microwave energy from the lamp. The solid section has multiple compliant fingers defined therein for engaging the periphery of a flange on the waveguide unit so that a hose clamp can easily secure the screen to the assembly. Screen units of this type having different mesh section configurations can be interchanged in the lamp assembly to produce different respective illumination patterns.