Sample records for high throughput tools

  1. High-Throughput, High-Precision Hot Testing Tool for High-Brightness...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Throughput, High-Precision Hot Testing Tool for High-Brightness Light-Emitting Diode Testing High-Throughput, High-Precision Hot Testing Tool for High-Brightness Light-Emitting...

  2. New Tools for High Throughput Chemistry and Biology 

    E-Print Network [OSTI]

    Galveia, Luciano Paulo Rosa

    2011-01-01T23:59:59.000Z

    New strategies for the high-throughput determination of protease substrate specificity using a dual colour microarray based format with a small library of FRET-based peptides were developed. Integral to this process was ...

  3. GeoChip 3.0: A High Throughput Tool for Analyzing Microbial Community, Composition, Structure, and Functional Activity

    SciTech Connect (OSTI)

    He, Zhili; Deng, Ye; Nostrand, Joy Van; Tu, Qichao; Xu, Meiying; Hemme, Chris; Wu, Liyou; Hazen, Terry; Zhou, Jizhong; Li, Xingyuan; Gentry, Terry; Yin, Yifeng; Liebich, Jost

    2010-05-17T23:59:59.000Z

    Microarray-based genomic technology has been widely used for microbial community analysis, and it is expected that microarray-based genomic technologies will revolutionize the analysis of microbial community structure, function and dynamics. A new generation of functional gene arrays (GeoChip 3.0) has been developed, with 27,812 probes covering 56,990 gene variants from 292 functional gene families involved in carbon, nitrogen, phosphorus and sulfur cycles, energy metabolism, antibiotic resistance, metal resistance, and organic contaminant degradation. Those probes were derived from 2,744, 140, and 262 species for bacteria, archaea, and fungi, respectively. GeoChip 3.0 has several other distinct features, such as a common oligo reference standard (CORS) for data normalization and comparison, a software package for data management and future updating, and the gyrB gene for phylogenetic analysis. Our computational evaluation of probe specificity indicated that all designed probes had a high specificity to their corresponding targets. Also, experimental analysis with synthesized oligonucleotides and genomic DNAs showed that only 0.0036percent-0.025percent false positive rates were observed, suggesting that the designed probes are highly specific under the experimental conditions examined. In addition, GeoChip 3.0 was applied to analyze soil microbial communities in a multifactor grassland ecosystem in Minnesota, USA, which demonstrated that the structure, composition, and potential activity of soil microbial communities significantly changed with the plant species diversity. All results indicate that GeoChip 3.0 is a high throughput powerful tool for studying microbial community functional structure, and linking microbial communities to ecosystem processes and functioning. To our knowledge, GeoChip 3.0 is the most comprehensive microarrays currently available for studying microbial communities associated with geobiochemical cycling, global climate change, bioenergy, agricuture, land use, ecosystem management, environmental cleanup and restoration, bioreactor systems, and human health.

  4. High throughput optical scanner

    DOE Patents [OSTI]

    Basiji, David A. (Seattle, WA); van den Engh, Gerrit J. (Seattle, WA)

    2001-01-01T23:59:59.000Z

    A scanning apparatus is provided to obtain automated, rapid and sensitive scanning of substrate fluorescence, optical density or phosphorescence. The scanner uses a constant path length optical train, which enables the combination of a moving beam for high speed scanning with phase-sensitive detection for noise reduction, comprising a light source, a scanning mirror to receive light from the light source and sweep it across a steering mirror, a steering mirror to receive light from the scanning mirror and reflect it to the substrate, whereby it is swept across the substrate along a scan arc, and a photodetector to receive emitted or scattered light from the substrate, wherein the optical path length from the light source to the photodetector is substantially constant throughout the sweep across the substrate. The optical train can further include a waveguide or mirror to collect emitted or scattered light from the substrate and direct it to the photodetector. For phase-sensitive detection the light source is intensity modulated and the detector is connected to phase-sensitive detection electronics. A scanner using a substrate translator is also provided. For two dimensional imaging the substrate is translated in one dimension while the scanning mirror scans the beam in a second dimension. For a high throughput scanner, stacks of substrates are loaded onto a conveyor belt from a tray feeder.

  5. Development and optimization of high-throughput zebrafish screening platform

    E-Print Network [OSTI]

    Koo, Bryan Kyo

    2010-01-01T23:59:59.000Z

    The high-throughput zebrafish screening platform is a revolutionary tool that enables subcellular precision in vivo whole animal screening of Danio Rerio. It can perform laser surgery and/or imaging in less than twenty ...

  6. High throughput protein production screening

    DOE Patents [OSTI]

    Beernink, Peter T. (Walnut Creek, CA); Coleman, Matthew A. (Oakland, CA); Segelke, Brent W. (San Ramon, CA)

    2009-09-08T23:59:59.000Z

    Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic sequences, including human cDNAs using PCR and IVT methods and detecting the proteins through fluorescence or immunoblot techniques. This invention can be used to identify optimized PCR and WT conditions, codon usages and mutations. The methods are readily automated and can be used for high throughput analysis of protein expression levels, interactions, and functional states.

  7. GeoChip 3.0: A High Throughput Tool for Analyzing Microbial Community, Composition, Structure, and Functional Activity

    E-Print Network [OSTI]

    He, Zhili

    2010-01-01T23:59:59.000Z

    as automatic updates. 3. GeoChip 3.0 analyses showed thatindicating that GeoChip 3.0 has a high specificity.evaluation of GeoChip 3.0 A. B. Clustering analysis of nifH

  8. High-Throughput/Combinatorial Techniques in Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D (presentation) High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D (presentation)...

  9. High Throughput/Combinatorial Screening of Hydrogen Storage Materials...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials: UOP Approaches High ThroughputCombinatorial Screening of Hydrogen Storage Materials: UOP Approaches Presentation by Adriaan Sachtler from the High Throughput...

  10. High-Throughput and Combinatorial Screening of Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-Throughput and Combinatorial Screening of Hydrogen Storage Materials (presentation) High-Throughput and Combinatorial Screening of Hydrogen Storage Materials (presentation)...

  11. Potential of High-Throughput Experimentation with Ammonia Borane...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of High-Throughput Experimentation with Ammonia Borane Solid Hydrogen Storage Materials (presentation) Potential of High-Throughput Experimentation with Ammonia Borane Solid...

  12. High throughput 3-D tissue cytometry

    E-Print Network [OSTI]

    Kwon, Hyuk-Sang, 1971-

    2007-01-01T23:59:59.000Z

    This thesis presents the ongoing technological development of high throughput 3-D tissue cytometry.and its applications in biomedicine. 3-D tissue cytometry has been developed in our laboratory based on two-photon microscopy ...

  13. High-throughput quantification of glycoprotein sialylation

    E-Print Network [OSTI]

    Markely, Lam Raga Anggara

    2011-01-01T23:59:59.000Z

    Sialic acid can improve qualities of therapeutic glycoproteins, such as circulatory half-life, biological activity, and solubility. In production of therapeutic glycoproteins, a high-throughput method (HTM) is required for ...

  14. High Throughput Materials Characterization John M. Gregoire

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Paper for Establishing a User Facility for Synchrotron-based High Throughput Materials Characterization John M. Gregoire 1 , Matthew J. Kramer 2 , Apurva Mehta 3 1 Joint Center for...

  15. High Throughput Operando Studies using Fourier Transform Infrared...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Throughput Operando Studies using Fourier Transform Infrared Imaging and Raman Spectroscopy. High Throughput Operando Studies using Fourier Transform Infrared Imaging and Raman...

  16. High-throughput Microfluidic Screening Platforms for Microalgae Study 

    E-Print Network [OSTI]

    Kim, Hyun Soo

    2014-12-15T23:59:59.000Z

    parallel studies are needed, however, current microalgae culture systems are lack of high-throughput screening capabilities, and thus not suitable for the parallel studies. Here, three different high-throughput microfluidic microalgae screening platforms...

  17. Chemistry & Biology Genome-Wide High-Throughput Mining

    E-Print Network [OSTI]

    Yin, Jun

    Chemistry & Biology Article Genome-Wide High-Throughput Mining of Natural-Product Biosynthetic Gene.01.006 SUMMARY We have developed a phage-display method for high-throughput mining of bacterial gene clus- ters

  18. High-throughput Microfluidic Screening Platforms for Microalgae Study

    E-Print Network [OSTI]

    Kim, Hyun Soo

    2014-12-15T23:59:59.000Z

    parallel studies are needed, however, current microalgae culture systems are lack of high-throughput screening capabilities, and thus not suitable for the parallel studies. Here, three different high-throughput microfluidic microalgae screening platforms...

  19. 2011 DoD High Performance Computing Modernization Program Users Group Conference A Web-based High-Throughput Tool for Next-Generation Sequence Annotation

    E-Print Network [OSTI]

    320 2011 DoD High Performance Computing Modernization Program Users Group Conference A Web deployed on the Mana Linux cluster at the Maui High Performance Computing Center. The two components

  20. Cell bioprinting as a potential high-throughput method for fabricating cell-based biosensors (CBBs)

    E-Print Network [OSTI]

    Xu, F.

    Cell-based biosensors (CBBs) are becoming an important tool for biosecurity applications and rapid diagnostics. For current CBBs technology, cell immobilization and high throughput fabrication are the main challenges. To ...

  1. Engineering a single cell microarray platform for high throughput DNA damage and repair analysis

    E-Print Network [OSTI]

    Weingeist, David McGregor

    2012-01-01T23:59:59.000Z

    DNA damage contributes to cancer, aging, and heritable diseases. Ironically, DNA damaging agents are also commonly used in current cancer treatment. We therefore need robust, high throughput, and inexpensive tools for ...

  2. High-Throughput/Combinatorial Techniques in Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    with a High Binding Energy (New Joint UC-BerkeleySymyx DoDDLA Project), Jeffrey Long, University of California, Berkeley High ThroughputCombinatorial Screening of Hydrogen...

  3. High Throughput Combinatorial Screening of Biometic Metal-Organic...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Throughput Combinatorial Screening of Biometic Metal-Organic Materials for Military Hydrogen-Storage Materials (New Joint Miami UNREL DoDDLA Project) (presentation) High...

  4. High throughput chemical munitions treatment system

    DOE Patents [OSTI]

    Haroldsen, Brent L. (Manteca, CA); Stofleth, Jerome H. (Albuquerque, NM); Didlake, Jr., John E. (Livermore, CA); Wu, Benjamin C-P (San Ramon, CA)

    2011-11-01T23:59:59.000Z

    A new High-Throughput Explosive Destruction System is disclosed. The new system is comprised of two side-by-side detonation containment vessels each comprising first and second halves that feed into a single agent treatment vessel. Both detonation containment vessels further comprise a surrounding ventilation facility. Moreover, the detonation containment vessels are designed to separate into two half-shells, wherein one shell can be moved axially away from the fixed, second half for ease of access and loading. The vessels are closed by means of a surrounding, clam-shell type locking seal mechanisms.

  5. High Throughput/Combinatorial Screening of Hydrogen Storage Materials...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials (presentation) High ThroughputCombinatorial Screening of Hydrogen Storage Materials (presentation) Presented at the U.S. Department of Energy's Hydrogen Storage Meeting...

  6. ORIGINAL PAPER Propylene Epoxidation: High-Throughput Screening of Supported

    E-Print Network [OSTI]

    Senkan, Selim M.

    ORIGINAL PAPER Propylene Epoxidation: High-Throughput Screening of Supported Metal Catalysts of propylene using molecular oxygen was studied on a variety of supported metal catalysts. The most promising Propylene Á Epoxidation Á Sol­gel Á High-throughput 1 Introduction Propylene oxide (PO) is an important raw

  7. Microfluidic Technologies for High-Throughput Screening Applications

    E-Print Network [OSTI]

    Quake, Stephen R.

    Microfluidic Technologies for High-Throughput Screening Applications Thesis by Todd Thorsen, patiently giving me advice on a large variety of subjects, ranging from microfluidics to optics of microfluidic devices for high-throughput screening applications, such as mutant enzyme libraries expressed

  8. Interactive Visual Analysis of High Throughput Text Streams

    SciTech Connect (OSTI)

    Steed, Chad A [ORNL; Potok, Thomas E [ORNL; Patton, Robert M [ORNL; Goodall, John R [ORNL; Maness, Christopher S [ORNL; Senter, James K [ORNL

    2012-01-01T23:59:59.000Z

    The scale, velocity, and dynamic nature of large scale social media systems like Twitter demand a new set of visual analytics techniques that support near real-time situational awareness. Social media systems are credited with escalating social protest during recent large scale riots. Virtual communities form rapidly in these online systems, and they occasionally foster violence and unrest which is conveyed in the users language. Techniques for analyzing broad trends over these networks or reconstructing conversations within small groups have been demonstrated in recent years, but state-of- the-art tools are inadequate at supporting near real-time analysis of these high throughput streams of unstructured information. In this paper, we present an adaptive system to discover and interactively explore these virtual networks, as well as detect sentiment, highlight change, and discover spatio- temporal patterns.

  9. High-Throughput Mass-Spectrometry Monitoring for Multisubstrate Enzymes

    E-Print Network [OSTI]

    Davis, Ben G.

    (EC 2.4.1.22), and the recently isolated Arabidopsis thaliana GT UGT72B1 (EC 2.4.1.-). The GAR (green a fast, high-throughput method for finding potential donors and acceptors from substrate libraries

  10. A GPU-INSPIRED SOFT PROCESSOR FOR HIGH-THROUGHPUT ACCELERATION

    E-Print Network [OSTI]

    Steffan, J. Gregory

    Methodology 35 6.1 System Simulation . . . . . . . A GPU-INSPIRED SOFT PROCESSOR FOR HIGH-THROUGHPUT ACCELERATION by Jeffrey Richard Code Kingyens Code Kingyens #12;Abstract A GPU-Inspired Soft Processor for High-Throughput Acceleration Jeffrey

  11. Agenda from the U.S. Department of Energy's High Throughput Screening...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    from the U.S. Department of Energy's High Throughput Screening of Hydrogen Storage Materials Workshop on June 26, 2007 Agenda from the U.S. Department of Energy's High Throughput...

  12. Engineering of a High-Throughput Screening System to Identify Cellulosic Biomass,

    E-Print Network [OSTI]

    California at Riverside, University of

    - grated high-throughput (HTP) screening pipeline. Herein, we report on the engineering of a novel HTP

  13. High-ThroughputTagging of Arabidopsis Proteins

    E-Print Network [OSTI]

    Citovsky, Vitaly

    ­0124 (N.C., G.D., N.V.R.); and The Arabidopsis Information Resource (S.L., S.Y.R.) and Carnegie Institution of Washington (S.L., D.E., S.Y.R), Stanford, California 94305 We developed a high their chromogenic reac- tion products (Taylor, 1997). The use of antigenic tags, such as the T7 or HA epitopes

  14. Methods and technologies for high-throughput and high-content small animal screening

    E-Print Network [OSTI]

    Rohde, Christopher, 1979-

    2012-01-01T23:59:59.000Z

    High-throughput and high-content screening (HTS and HCS) of whole animals requires their immobilization for high-resolution imaging and manipulation. Here we present methods to enable HTS and HCS of the nematode Caenorhabditis ...

  15. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements RecentlyElectronicResources ResourcesRobust, High-Throughput Analysis of

  16. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Scienceand Requirements RecentlyElectronicResources ResourcesRobust, High-Throughput Analysis

  17. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 toAdvances WindRobust, High-Throughput

  18. automating high-throughput blast: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to electron transfer dissoci- ation (ETD) mass spectrometry Shorter, James 15 Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium...

  19. automated high-throughput cultivations: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to electron transfer dissoci- ation (ETD) mass spectrometry Shorter, James 15 Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium...

  20. High Throughput Pretreatment and Enzyme Hydrolysis of Biomass: Screening Recalcitrance in Large Sample Populations (Presentation)

    SciTech Connect (OSTI)

    Decker, S. R.

    2010-10-01T23:59:59.000Z

    Presentation on the execution of the first high-throughput thermochemical pretreatment/enzyme digestion pipeline for screening biomass for recalcitrance.

  1. Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

    E-Print Network [OSTI]

    Wu, Zhigang

    2009-01-01T23:59:59.000Z

    Soft inertial microfluidics for high throughput separation1 Introduction Microfluidics has gained significant advancesof mammalian cells using microfluidics 3,4 , there have been

  2. A microfluidic platform for high-throughput multiplexed protein quantitation

    E-Print Network [OSTI]

    Volpetti, Francesca; Maerkl, Sebastian

    2014-01-01T23:59:59.000Z

    We present a high-throughput microfluidic platform capable of quantitating up to 384 biomarkers in 4 distinct samples by immunoassay. The microfluidic device contains 384 unit cells, which can be individually programmed with pairs of capture and detection antibody. Samples are quantitated in each unit cell by four independent MITOMI detection areas, allowing four samples to be analyzed in parallel for a total of 1,536 assays per device. We show that the device can be pre-assembled and stored for weeks at elevated temperature and we performed proof-of-concept experiments simultaneously quantitating IL-6, IL-1\\b{eta}, TNF-{\\alpha}, PSA, and GFP. Finally, we show that the platform can be used to identify functional antibody combinations by screening 64 antibody combinations requiring up to 384 unique assays per device.

  3. Generalized schemes for high throughput manipulation of the Desulfovibrio vulgaris Hildenborough genome

    SciTech Connect (OSTI)

    Chhabra, S.R.; Butland, G.; Elias, D.; Chandonia, J.-M.; Fok, V.; Juba, T.; Gorur, A.; Allen, S.; Leung, C.-M.; Keller, K.; Reveco, S.; Zane, G.; Semkiw, E.; Prathapam, R.; Gold, B.; Singer, M.; Ouellet, M.; Sazakal, E.; Jorgens, D.; Price, M.; Witkowska, E.; Beller, H.; Hazen, T.C.; Biggin, M.; Auer, M.; Wall, J.; Keasling, J.

    2011-07-15T23:59:59.000Z

    The ability to conduct advanced functional genomic studies of the thousands of sequenced bacteria has been hampered by the lack of available tools for making high- throughput chromosomal manipulations in a systematic manner that can be applied across diverse species. In this work, we highlight the use of synthetic biological tools to assemble custom suicide vectors with reusable and interchangeable DNA “parts” to facilitate chromosomal modification at designated loci. These constructs enable an array of downstream applications including gene replacement and creation of gene fusions with affinity purification or localization tags. We employed this approach to engineer chromosomal modifications in a bacterium that has previously proven difficult to manipulate genetically, Desulfovibrio vulgaris Hildenborough, to generate a library of over 700 strains. Furthermore, we demonstrate how these modifications can be used for examining metabolic pathways, protein-protein interactions, and protein localization. The ubiquity of suicide constructs in gene replacement throughout biology suggests that this approach can be applied to engineer a broad range of species for a diverse array of systems biological applications and is amenable to high-throughput implementation.

  4. High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation

    E-Print Network [OSTI]

    Zandstra, Peter W.

    High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation a microfluidic approach for high-throughput generation of 3D microenvironments with different elasticity for studies of cell fate. The generation of agarose microgels with different elastic moduli was achieved by (i

  5. Assessing the Thermoelectric Properties of Sintered Compounds via High-Throughput Ab-Initio Calculations

    E-Print Network [OSTI]

    Curtarolo, Stefano

    Assessing the Thermoelectric Properties of Sintered Compounds via High-Throughput Ab Database have been considered as nanograined, sintered-powder thermoelectrics with the high-throughput ab the electronic band gap and the carrier effective mass, and that the probability of having large thermoelectric

  6. High throughput energy efficient multi-FFT architecture on FPGAs (Draft)

    E-Print Network [OSTI]

    Prasanna, Viktor K.

    computing, High throughput FFT, Energy efficient design I. INTRODUCTION As FPGAs are programmed specifically in spread spec- trum receiver [4]. In the design of high throughput FFT architectures, energy-efficient design techniques can be used to maximize performance under power dissipation constraints. The power

  7. Parallel Interleaver Architecture with New Scheduling Scheme for High Throughput Configurable Turbo Decoder

    E-Print Network [OSTI]

    Mellor-Crummey, John

    Parallel Interleaver Architecture with New Scheduling Scheme for High Throughput Configurable Turbo}@rice.edu, yuanbinguo@huawei.com Abstract--Parallel architecture is required for high throughput turbo decoder to meet also shows great flexibility and scalability compared to prior work. Index Terms--VLSI, turbo decoder

  8. Adaptive Congestion Control in Broadband-ISDN: High Throughput with Sustained Quality of Service

    E-Print Network [OSTI]

    Pitsillides, Andreas

    ). The controller regulates QoS by manipulating the flow of controllable traffic into the network. Controllability. In this paper we use an adaptive feedback and feedforward control system to maximise throughput such that the QoAdaptive Congestion Control in Broadband-ISDN: High Throughput with Sustained Quality of Service

  9. On-chip sub-cellular resolution whole-animal manipulation for high-throughput in vivo screening

    E-Print Network [OSTI]

    Rohde, Christopher Benjamin

    We present a suite of technologies that can be combined to perform complex high-throughput whole-animal genetic and drug screens. When used in various combinations, these devices facilitate a variety of high-throughput ...

  10. Solion ion source for high-efficiency, high-throughput solar cell manufacturing

    SciTech Connect (OSTI)

    Koo, John, E-mail: john-koo@amat.com; Binns, Brant; Miller, Timothy; Krause, Stephen; Skinner, Wesley; Mullin, James [Applied Materials, Inc., Varian Semiconductor Equipment Business Unit, 35 Dory Road, Gloucester, Massachusetts 01930 (United States)] [Applied Materials, Inc., Varian Semiconductor Equipment Business Unit, 35 Dory Road, Gloucester, Massachusetts 01930 (United States)

    2014-02-15T23:59:59.000Z

    In this paper, we introduce the Solion ion source for high-throughput solar cell doping. As the source power is increased to enable higher throughput, negative effects degrade the lifetime of the plasma chamber and the extraction electrodes. In order to improve efficiency, we have explored a wide range of electron energies and determined the conditions which best suit production. To extend the lifetime of the source we have developed an in situ cleaning method using only existing hardware. With these combinations, source life-times of >200 h for phosphorous and >100 h for boron ion beams have been achieved while maintaining 1100 cell-per-hour production.

  11. Advances in High Throughput Screening of Biomass Recalcitrance (Poster)

    SciTech Connect (OSTI)

    Turner, G. B.; Decker, S. R.; Tucker, M. P.; Law, C.; Doeppke, C.; Sykes, R. W.; Davis, M. F.; Ziebell, A.

    2012-06-01T23:59:59.000Z

    This was a poster displayed at the Symposium. Advances on previous high throughput screening of biomass recalcitrance methods have resulted in improved conversion and replicate precision. Changes in plate reactor metallurgy, improved preparation of control biomass, species-specific pretreatment conditions, and enzymatic hydrolysis parameters have reduced overall coefficients of variation to an average of 6% for sample replicates. These method changes have improved plate-to-plate variation of control biomass recalcitrance and improved confidence in sugar release differences between samples. With smaller errors plant researchers can have a higher degree of assurance more low recalcitrance candidates can be identified. Significant changes in plate reactor, control biomass preparation, pretreatment conditions and enzyme have significantly reduced sample and control replicate variability. Reactor plate metallurgy significantly impacts sugar release aluminum leaching into reaction during pretreatment degrades sugars and inhibits enzyme activity. Removal of starch and extractives significantly decreases control biomass variability. New enzyme formulations give more consistent and higher conversion levels, however required re-optimization for switchgrass. Pretreatment time and temperature (severity) should be adjusted to specific biomass types i.e. woody vs. herbaceous. Desalting of enzyme preps to remove low molecular weight stabilizers and improved conversion levels likely due to water activity impacts on enzyme structure and substrate interactions not attempted here due to need to continually desalt and validate precise enzyme concentration and activity.

  12. ENHANCED DOE HIGH LEVEL WASTE MELTER THROUGHPUT STUDIES: SRNL GLASS SELECTION STRATEGY

    SciTech Connect (OSTI)

    Raszewski, F; Tommy Edwards, T; David Peeler, D

    2008-01-23T23:59:59.000Z

    The Department of Energy has authorized a team of glass formulation and processing experts at the Savannah River National Laboratory (SRNL), the Pacific Northwest National Laboratory (PNNL), and the Vitreous State Laboratory (VSL) at Catholic University of America to develop a systematic approach to increase high level waste melter throughput (by increasing waste loading with minimal or positive impacts on melt rate). This task is aimed at proof-of-principle testing and the development of tools to improve waste loading and melt rate, which will lead to higher waste throughput. Four specific tasks have been proposed to meet these objectives (for details, see WSRC-STI-2007-00483): (1) Integration and Oversight, (2) Crystal Accumulation Modeling (led by PNNL)/Higher Waste Loading Glasses (led by SRNL), (3) Melt Rate Evaluation and Modeling, and (4) Melter Scale Demonstrations. Task 2, Crystal Accumulation Modeling/Higher Waste Loading Glasses is the focus of this report. The objective of this study is to provide supplemental data to support the possible use of alternative melter technologies and/or implementation of alternative process control models or strategies to target higher waste loadings (WLs) for the Defense Waste Processing Facility (DWPF)--ultimately leading to higher waste throughputs and a reduced mission life. The glass selection strategy discussed in this report was developed to gain insight into specific technical issues that could limit or compromise the ability of glass formulation efforts to target higher WLs for future sludge batches at the Savannah River Site (SRS). These technical issues include Al-dissolution, higher TiO{sub 2} limits and homogeneity issues for coupled-operations, Al{sub 2}O{sub 3} solubility, and nepheline formation. To address these technical issues, a test matrix of 28 glass compositions has been developed based on 5 different sludge projections for future processing. The glasses will be fabricated and characterized based on the protocols outlined in the SRNL Task and Quality Assurance (QA) plan.

  13. Towards Chip Scale Liquid Chromatography and High Throughput Immunosensing

    SciTech Connect (OSTI)

    Ni, J.

    2000-09-21T23:59:59.000Z

    This work describes several research projects aimed towards developing new instruments and novel methods for high throughput chemical and biological analysis. Approaches are taken in two directions. The first direction takes advantage of well-established semiconductor fabrication techniques and applies them to miniaturize instruments that are workhorses in analytical laboratories. Specifically, the first part of this work focused on the development of micropumps and microvalves for controlled fluid delivery. The mechanism of these micropumps and microvalves relies on the electrochemically-induced surface tension change at a mercury/electrolyte interface. A miniaturized flow injection analysis device was integrated and flow injection analyses were demonstrated. In the second part of this work, microfluidic chips were also designed, fabricated, and tested. Separations of two fluorescent dyes were demonstrated in microfabricated channels, based on an open-tubular liquid chromatography (OT LC) or an electrochemically-modulated liquid chromatography (EMLC) format. A reduction in instrument size can potentially increase analysis speed, and allow exceedingly small amounts of sample to be analyzed under diverse separation conditions. The second direction explores the surface enhanced Raman spectroscopy (SERS) as a signal transduction method for immunoassay analysis. It takes advantage of the improved detection sensitivity as a result of surface enhancement on colloidal gold, the narrow width of Raman band, and the stability of Raman scattering signals to distinguish several different species simultaneously without exploiting spatially-separated addresses on a biochip. By labeling gold nanoparticles with different Raman reporters in conjunction with different detection antibodies, a simultaneous detection of a dual-analyte immunoassay was demonstrated. Using this scheme for quantitative analysis was also studied and preliminary dose-response curves from an immunoassay of a mo del antigen were obtained. Simultaneous detection of several analytes at the same address can potentially increase the analysis speed, and can further expand the analysis capability of a microarray chip.

  14. A high throughput (>90%), large compensation range, single-prism femtosecond pulse compressor

    E-Print Network [OSTI]

    Kong, Lingjie

    2013-01-01T23:59:59.000Z

    We demonstrate a high throughput, large compensation range, single-prism femtosecond pulse compressor, using a single prism and two roof mirrors. The compressor has zero angular dispersion, zero spatial dispersion, zero pulse-front tilt, and unity magnification. The high efficiency is achieved by adopting two roof mirrors as the retroreflectors. We experimentally achieved ~ -14500 fs2 group delay dispersion (GDD) with 30 cm of prism tip-roof mirror prism separation, and ~90.7% system throughput with the current implementation. With better components, the throughput can be even higher.

  15. CellVisualizer : exploring hierarchical, multi-dimensional data with applications to high-throughput microscopy

    E-Print Network [OSTI]

    Kang, InHan

    2006-01-01T23:59:59.000Z

    In this thesis, we present a system for visualizing hierarchical, multi-dimensional, memory-intensive datasets. Specifically, we designed an interactive system to visualize data collected by high-throughput microscopy and ...

  16. Development of High-Throughput Microfluidic Impedance Spectroscopy Platform for Analyzing Microdroplets in Droplet Microfluidic System 

    E-Print Network [OSTI]

    Sobahi, Nebras MohammedKamal A.

    2014-07-22T23:59:59.000Z

    This thesis presents the development of a high-throughput microfluidic impedance spectroscopy platform for electrically detecting analyzing impedance measurements of non-contact and label free microdroplets. This microfluidic impedance spectroscopy...

  17. Infrastructure to support ultra high throughput biodosimetry screening after a radiological event

    E-Print Network [OSTI]

    Brenner, David Jonathan

    GUY GARTY1 , ANDREW KARAM2 , & DAVID J. BRENNER3 1 Radiological Research Accelerator Facility, Radiological Research Accelerator Facility, Nevis Laboratories, Columbia UniverInfrastructure to support ultra high throughput biodosimetry screening after a radiological event

  18. The Materials genome : rapid materials screening for renewable energy using high-throughput density functional theory

    E-Print Network [OSTI]

    Jain, Anubhav, Ph.D. Massachusetts Institute of Technology

    2011-01-01T23:59:59.000Z

    This thesis relates to the emerging field of high-throughput density functional theory (DFT) computation for materials design and optimization. Although highthroughput DFT is a promising new method for materials discovery, ...

  19. Attendees list from the U.S. Department of Energy's High Throughput...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Attendees list from the U.S. Department of Energy's High Throughput Screening of Hydrogen Storage Materials Workshop on June 26, 2007 Attendees list from the U.S. Department of...

  20. Molecular display of synthetic oligonucleotide libraries and their analysis with high throughput DNA sequencing

    E-Print Network [OSTI]

    Larman, Harry Benjamin

    2012-01-01T23:59:59.000Z

    High throughput methods in molecular biology have changed the landscape of biomedical research. In particular, advances in massively parallel DNA sequencing and synthesis technologies are defining our genomes and the ...

  1. An instrument for high-throughput measurements of fiber mechanical properties

    E-Print Network [OSTI]

    Kristofek, Grant William, 1980-

    2005-01-01T23:59:59.000Z

    In this thesis, an instrument is designed and constructed for the purpose of measuring the mechanical properties of single fibers. The instrument is intended to provide high throughput measurement of single fiber geometric ...

  2. A microfluidic device for high throughput bacterial biofilm studies Jeongyun Kim,a

    E-Print Network [OSTI]

    Wood, Thomas K.

    A microfluidic device for high throughput bacterial biofilm studies Jeongyun Kim,a Manjunath Hegde of biofilm community formation. Here, we describe the development of a PDMS-based two-layer microfluidic flow

  3. Development of High-Throughput Microfluidic Impedance Spectroscopy Platform for Analyzing Microdroplets in Droplet Microfluidic System

    E-Print Network [OSTI]

    Sobahi, Nebras MohammedKamal A.

    2014-07-22T23:59:59.000Z

    This thesis presents the development of a high-throughput microfluidic impedance spectroscopy platform for electrically detecting analyzing impedance measurements of non-contact and label free microdroplets. This microfluidic impedance spectroscopy...

  4. Optical Multiplexing for High-Throughput Spectroscopic Analysis.

    E-Print Network [OSTI]

    Ahmed, Saadiah

    2012-05-03T23:59:59.000Z

    in optical biosensor testing as it provides greater throughput and scalability while being an economical and compact solution. v NOMENCLATURE MFPF Multi Frequency Phase Fluorometer MUX Multiplexer LED Light Emitting Diode DIO Digital Input... oxidase in hybrid silicate microsphere that is coated with nanofilm and reference dye (RITC) (Fig. 1) [2]. The phosphorescent dye is excited by a green light from a LED (light emitting diode) to emit luminescence, the intensity of which is dependent...

  5. High Throughput Synthesis of Uniform Biocompatible Polymer Beads with High Quantum Dot Loading Using Microfluidic Jet-Mode Breakup

    E-Print Network [OSTI]

    Lee, Seung-Kon

    Uniform polymer microbeads with highly loaded quantum dots (QDs) are produced using high-throughput coherent jet breakup of a biocompatible poly(ethylene glycol) diacrylate (PEGDA) prepolymer resin, followed by in-line ...

  6. High-throughput scanning confocal microscope for single molecule Chandran R. Sabanayagam, John S. Eid, and Amit Mellera)

    E-Print Network [OSTI]

    Meller, Amit

    High-throughput scanning confocal microscope for single molecule analysis Chandran R. Sabanayagam and probing of single molecules, and an automatic focusing feature that enables the unattended scanning

  7. Droplet microfluidic technology for single-cell high-throughput screening

    E-Print Network [OSTI]

    Perrimon, Norbert

    Droplet microfluidic technology for single-cell high-throughput screening Eric Brouzesa,b,1 (received for review March 31, 2009) We present a droplet-based microfluidic technology that enables high our droplet microfluidic platform is modular, robust, uses no moving parts, and has a wide range

  8. High-Throughput Contention-Free Concurrent Interleaver Architecture for Multi-Standard Turbo Decoder

    E-Print Network [OSTI]

    Mellor-Crummey, John

    High-Throughput Contention-Free Concurrent Interleaver Architecture for Multi-Standard Turbo paral- lel turbo decoder architectures have been developed. However, the interleaver has become a major that can efficiently solve the memory conflict problem for parallel turbo decoders with very high

  9. Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome

    E-Print Network [OSTI]

    Bourne, Philip E.

    Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome Annotation software on a high performance computing platform such as the grid. The Encyclopedia of Life (EOL) project application to drive grid software development. It is a flagship application for the TeraGrid project [3

  10. A Warm Near-Infrared High-Resolution Spectrograph with Very High Throughput (WINERED)

    E-Print Network [OSTI]

    Kondo, Sohei; Kobayashi, Naoto; Yasui, Chikako; Mito, Hiroyuki; Fukue, Kei; Nakanishi, Kenshi; Kawanishi, Takafumi; Nakaoka, Tetsuya; Otsubo, Shogo; Kinoshita, Masaomi; Kitano, Ayaka; Hamano, Satoshi; Mizumoto, Misaki; Yamamoto, Ryo; Izumi, Natsuko; Matsunaga, Noriyuki; Kawakita, Hideyo

    2015-01-01T23:59:59.000Z

    WINERED is a newly built high-efficiency (throughput$ > 25-30\\%$) and high-resolution spectrograph customized for short NIR bands at 0.9-1.35 ${\\rm \\mu}$m. WINERED is equipped with ambient temperature optics and a cryogenic camera using a 1.7 ${\\rm \\mu}$m cut-off HgCdTe HAWAII-2RG array detector. WINERED has two grating modes: one with a conventional reflective echelle grating (R$\\sim$28,300), which covers 0.9-1.35 $\\mu$m simultaneously, the other with ZnSe or ZnS immersion grating (R$\\sim$100,000). We have completed the development of WINERED except for the immersion grating, and started engineering and science observations at the Nasmyth platform of the 1.3 m Araki Telescope at Koyama Astronomical Observatory of Kyoto-Sangyo University in Japan. We confirmed that the spectral resolution ($R\\sim$ 28,300) and the throughput ($>$ 40\\% w/o telescope/atmosphere/array QE) meet our specifications. We measured ambient thermal backgrounds (e.g., 0.06 ${\\rm [e^{-}/sec/pixel]}$ at 287 K), which are roughly consistent ...

  11. Low Cost Lithography Tool for High Brightness LED Manufacturing

    SciTech Connect (OSTI)

    Andrew Hawryluk; Emily True

    2012-06-30T23:59:59.000Z

    The objective of this activity was to address the need for improved manufacturing tools for LEDs. Improvements include lower cost (both capital equipment cost reductions and cost-ofownership reductions), better automation and better yields. To meet the DOE objective of $1- 2/kilolumen, it will be necessary to develop these highly automated manufacturing tools. Lithography is used extensively in the fabrication of high-brightness LEDs, but the tools used to date are not scalable to high-volume manufacturing. This activity addressed the LED lithography process. During R&D and low volume manufacturing, most LED companies use contact-printers. However, several industries have shown that these printers are incompatible with high volume manufacturing and the LED industry needs to evolve to projection steppers. The need for projection lithography tools for LED manufacturing is identified in the Solid State Lighting Manufacturing Roadmap Draft, June 2009. The Roadmap states that Projection tools are needed by 2011. This work will modify a stepper, originally designed for semiconductor manufacturing, for use in LED manufacturing. This work addresses improvements to yield, material handling, automation and throughput for LED manufacturing while reducing the capital equipment cost.

  12. High-Throughput Screening of Gene Function in Stem Cells Using Clonal Microarrays

    E-Print Network [OSTI]

    Schaffer, David V.

    High-Throughput Screening of Gene Function in Stem Cells Using Clonal Microarrays RANDOLPH S. ASHTON,a JOSEPH PELTIER,b CHRISTOPHER A. FASANO,c ANALEAH O'NEILL,b JOSHUA LEONARD,b SALLY TEMPLE,c DAVID. Sox2 transcription factor · Akt1 · Neural progenitor cells · Soft lithography ABSTRACT We describe

  13. High-throughput imaging of heterogeneous cell organelles with an X-ray laser

    SciTech Connect (OSTI)

    Hantke, Max, F.

    2014-11-17T23:59:59.000Z

    Preprocessed detector images that were used for the paper "High-throughput imaging of heterogeneous cell organelles with an X-ray laser". The CXI file contains the entire recorded data - including both hits and blanks. It also includes down-sampled images and LCLS machine parameters. Additionally, the Cheetah configuration file is attached that was used to create the pre-processed data.

  14. High-throughput imaging of heterogeneous cell organelles with an X-ray laser

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Hantke, Max, F.

    Preprocessed detector images that were used for the paper "High-throughput imaging of heterogeneous cell organelles with an X-ray laser". The CXI file contains the entire recorded data - including both hits and blanks. It also includes down-sampled images and LCLS machine parameters. Additionally, the Cheetah configuration file is attached that was used to create the pre-processed data.

  15. Development and operation of a high-throughput accurate-wavelength lens-based spectrometera)

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bell, Ronald E.

    2014-11-01T23:59:59.000Z

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy more »wavelength calibration.« less

  16. Treatability studies on different refinery wastewater samples using high-throughput microbial electrolysis cells (MECs)

    E-Print Network [OSTI]

    Treatability studies on different refinery wastewater samples using high-throughput microbial, University Park, PA 16802, USA h i g h l i g h t s Refinery wastewaters were tested as fuels in MECs effective for treatment or pre-treatment of some refinery wastewaters. The best way to start up MECs

  17. Optical microplates for high-throughput screening of photosynthesis in lipid-producing algae{,

    E-Print Network [OSTI]

    Basu, Amar S.

    Optical microplates for high-throughput screening of photosynthesis in lipid- producing algae-producing algae of interest in 2nd generation biofuels. By conducting 96 experiments in parallel, photoirradiance the study of photosynthesis in algae. Societal challenges in energy sustainability have renewed interest

  18. Applied Catalysis A: General 254 (2003) 97106 Photoionization detection (PID) as a high throughput

    E-Print Network [OSTI]

    Senkan, Selim M.

    Applied Catalysis A: General 254 (2003) 97­106 Photoionization detection (PID) as a high throughput 2002 Abstract A versatile photoionization detection (PID) system has been developed to rapidly screen libraries of catalytic materials. The PID approach involves the use of an appropriately selected dc

  19. A High-Throughput Method to Examine Protein-Nucleotide Interactions Identifies Targets of the Bacterial

    E-Print Network [OSTI]

    A High-Throughput Method to Examine Protein- Nucleotide Interactions Identifies Targets can easily be applied to examine multiple protein-protein, protein-nucleotide and nucleotide-nucleotide Protein-Nucleotide Interactions Identifies Targets of the Bacterial Transcriptional Regulatory Protein Fur

  20. Oblique-incidence reflectivity difference microscope for label-free high-throughput detection of biochemical

    E-Print Network [OSTI]

    Zhu, Xiangdong

    Oblique-incidence reflectivity difference microscope for label-free high-throughput detection (OI-RD) microscope, a form of polarization-modulated imaging ellipsometer, for label on the polarizer­ compensator­sample­analyzer scheme and under the off-null condition, a polarization-modulated OI

  1. HIGH-THROUGHPUT CELL AND PARTICLE CHARACTERIZATION USING ISO-DIELECTRIC

    E-Print Network [OSTI]

    Voldman, Joel

    HIGH-THROUGHPUT CELL AND PARTICLE CHARACTERIZATION USING ISO-DIELECTRIC SEPARATION Michael D. Vahey conductivity. Using a re- cently developed separation method - iso-dielectric separation (IDS) - we character for developing new screens. THEORY We recently developed a separa- tion method, called iso-dielectric sepa

  2. automated high throughput: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of such a more database-centric approach. Roehm, Uwe 2009-01-01 31 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites...

  3. High-Throughput and Combinatorial Screening of Hydrogen Storage...

    Broader source: Energy.gov (indexed) [DOE]

    groups at: U. Geneva (Switzerland), MPI (Germany), Stockholm University (Sweden), IFE (Norway), SRNL (USA), U. Tohoku, AIST (Japan) High-pressure Sintering Technique for Screening...

  4. GeoChip 3.0 as a high-thoughput tool for analyzing microbial community composition, structure, and functional activity

    E-Print Network [OSTI]

    He, Z.

    2010-01-01T23:59:59.000Z

    GeoChip 3.0 as a High-Throughput Tool for Analyzinggene arrays (FGAs; GeoChip 3.0) has been developed, with ~contaminant degradation. GeoChip 3.0 also has several other

  5. High-throughput comparison of gene fitness among related bacteria

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    having a sum of the two percentile ranks less than 30% (less than the 15 th percentile). Additional files Additionala threshold of the 15 th percentile for “highly selected”

  6. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    described here, which the research team believes will help usher in the next phase of genomics research. The high flux, brilliance, and focus of the x rays from ALS Beamline 12.3.1...

  7. Uranium Transport in a High-Throughput Electrorefiner for EBR-II Blanket Fuel

    SciTech Connect (OSTI)

    Ahluwalia, Rajesh K.; Hua, Thanh Q.; Vaden, DeeEarl [Argonne National Laboratory (United States)

    2004-01-15T23:59:59.000Z

    A unique high-throughput Mk-V electrorefiner is being used in the electrometallurgical treatment of the metallic sodium-bonded blanket fuel from the Experimental Breeder Reactor II. Over many cycles, it transports uranium back and forth between the anodic fuel dissolution baskets and the cathode tubes until, because of imperfect adherence of the dendrites, it all ends up in the product collector at the bottom. The transport behavior of uranium in the high-throughput electrorefiner can be understood in terms of the sticking coefficients for uranium adherence to the cathode tubes in the forward direction and to the dissolution baskets in the reverse direction. The sticking coefficients are inferred from the experimental voltage and current traces and are correlated in terms of a single parameter representing the ratio of the cell current to the limiting current at the surface acting as the cathode. The correlations are incorporated into an engineering model that calculates the transport of uranium in the different modes of operation. The model also uses the experimentally derived electrorefiner operating maps that describe the relationship between the cell voltage and the cell current for the three principal transport modes. It is shown that the model correctly simulates the cycle-to-cycle variation of the voltage and current profiles. The model is used to conduct a parametric study of electrorefiner throughput rate as a function of the principal operating parameters. The throughput rate is found to improve with lowering of the basket rotation speed, reduction of UCl{sub 3} concentration in salt, and increasing the maximum cell current or cut-off voltage. Operating conditions are identified that can improve the throughput rate by 60 to 70% over that achieved at present.

  8. High-Throughput Analytical Model to Evaluate Materials for Temperature

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem NotEnergy,ARMFormsGasReleaseSpeechesHallNot Logged3 HanfordHarry|High-PoweredSwing

  9. Melter Throughput Enhancements for High-Iron HLW

    SciTech Connect (OSTI)

    Kruger, A. A. [Department of Energy, Office of River Protection, Richland, Washington (United States); Gan, Hoa [The Catholic University of America, Washington, DC (United States); Joseph, Innocent [The Catholic University of America, Washington, DC (United States); Pegg, Ian L. [The Catholic University of America, Washington, DC (United States); Matlack, Keith S. [The Catholic University of America, Washington, DC (United States); Chaudhuri, Malabika [The Catholic University of America, Washington, DC (United States); Kot, Wing [The Catholic University of America, Washington, DC (United States)

    2012-12-26T23:59:59.000Z

    This report describes work performed to develop and test new glass and feed formulations in order to increase glass melting rates in high waste loading glass formulations for HLW with high concentrations of iron. Testing was designed to identify glass and melter feed formulations that optimize waste loading and waste processing rate while meeting all processing and product quality requirements. The work included preparation and characterization of crucible melts to assess melt rate using a vertical gradient furnace system and to develop new formulations with enhanced melt rate. Testing evaluated the effects of waste loading on glass properties and the maximum waste loading that can be achieved. The results from crucible-scale testing supported subsequent DuraMelter 100 (DM100) tests designed to examine the effects of enhanced glass and feed formulations on waste processing rate and product quality. The DM100 was selected as the platform for these tests due to its extensive previous use in processing rate determination for various HLW streams and glass compositions.

  10. Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

    SciTech Connect (OSTI)

    Hura, Greg L.; Menon, Angeli L.; Hammel, Michal; Rambo, Robert P.; Poole II, Farris L.; Tsutakawa, Susan E.; Jenney Jr, Francis E.; Classen, Scott; Frankel, Kenneth A.; Hopkins, Robert C.; Yang, Sungjae; Scott, Joseph W.; Dillard, Bret D.; Adams, Michael W. W.; Tainer, John A.

    2009-07-20T23:59:59.000Z

    We present an efficient pipeline enabling high-throughput analysis of protein structure in solution with small angle X-ray scattering (SAXS). Our SAXS pipeline combines automated sample handling of microliter volumes, temperature and anaerobic control, rapid data collection and data analysis, and couples structural analysis with automated archiving. We subjected 50 representative proteins, mostly from Pyrococcus furiosus, to this pipeline and found that 30 were multimeric structures in solution. SAXS analysis allowed us to distinguish aggregated and unfolded proteins, define global structural parameters and oligomeric states for most samples, identify shapes and similar structures for 25 unknown structures, and determine envelopes for 41 proteins. We believe that high-throughput SAXS is an enabling technology that may change the way that structural genomics research is done.

  11. Advances in high-throughput speed, low-latency communication for embedded instrumentation ( 7th Annual SFAF Meeting, 2012)

    ScienceCinema (OSTI)

    Jordan, Scott [Physik Instrumente

    2013-02-11T23:59:59.000Z

    Scott Jordan on "Advances in high-throughput speed, low-latency communication for embedded instrumentation" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  12. High Throughput Plasmid Sequencing with Illumina and CLC Bio (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema (OSTI)

    Athavale, Ajay [Monsanto

    2013-01-25T23:59:59.000Z

    Ajay Athavale (Monsanto) presents "High Throughput Plasmid Sequencing with Illumina and CLC Bio" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  13. Evaluation of Tavorite-Structured Cathode Materials for Lithium-Ion Batteries Using High-Throughput Computing

    E-Print Network [OSTI]

    Mueller, Tim

    Cathode materials with structure similar to the mineral tavorite have shown promise for use in lithium-ion batteries, but this class of materials is relatively unexplored. We use high-throughput density-functional-theory ...

  14. High-throughput data mined prediction of inorganic compounds and computational discovery of new lithium-ion battery cathode materials

    E-Print Network [OSTI]

    Hautier, Geoffroy (Geoffroy T. F.)

    2011-01-01T23:59:59.000Z

    The ability to computationally predict the properties of new materials, even prior to their synthesis, has been made possible due to the current accuracy of modern ab initio techniques. In some cases, high-throughput ...

  15. High Throughput Computing Impact on Meta Genomics (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    SciTech Connect (OSTI)

    Gore, Brooklin [Morgridge Institute for Research] [Morgridge Institute for Research

    2011-10-12T23:59:59.000Z

    This presentation includes a brief background on High Throughput Computing, correlating gene transcription factors, optical mapping, genotype to phenotype mapping via QTL analysis, and current work on next gen sequencing.

  16. 2008NaturePublishingGrouphttp://www.nature.com/naturemethods BAC TransgeneOmics: a high-throughput method for

    E-Print Network [OSTI]

    Cai, Long

    to assess protein function at high throughput. Here we describe a fast and reliable pipeline to study ubiquitous or tissue-specific promoters. As a result they do not reproduce the endogenous regulation

  17. High Throughput Computing Impact on Meta Genomics (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    ScienceCinema (OSTI)

    Gore, Brooklin [Morgridge Institute for Research

    2013-01-22T23:59:59.000Z

    This presentation includes a brief background on High Throughput Computing, correlating gene transcription factors, optical mapping, genotype to phenotype mapping via QTL analysis, and current work on next gen sequencing.

  18. Coev2Net: a computational framework for boosting confidence in high-throughput protein-protein interaction datasets

    E-Print Network [OSTI]

    Hosur, Raghavendra

    Improving the quality and coverage of the protein interactome is of tantamount importance for biomedical research, particularly given the various sources of uncertainty in high-throughput techniques. We introduce a ...

  19. A high-throughput, high-resolution spectrometer for mapping the heliopause and 3-D Solar Wind using He+ 30.4nm

    E-Print Network [OSTI]

    California at Berkeley, University of

    A high-throughput, high-resolution spectrometer for mapping the heliopause and 3-D Solar Wind using Entrance slit farm with ~ 1000 slits Photon counting imager Concave grating used near normal incidence >> Need a higher throughput diffuse EUV spectrometer solar wind respond to coronal

  20. High-throughput method for optimum solubility screening for homogeneity and crystallization of proteins

    DOE Patents [OSTI]

    Kim, Sung-Hou (Moraga, CA); Kim, Rosalind (Moraga, CA); Jancarik, Jamila (Walnut Creek, CA)

    2012-01-31T23:59:59.000Z

    An optimum solubility screen in which a panel of buffers and many additives are provided in order to obtain the most homogeneous and monodisperse protein condition for protein crystallization. The present methods are useful for proteins that aggregate and cannot be concentrated prior to setting up crystallization screens. A high-throughput method using the hanging-drop method and vapor diffusion equilibrium and a panel of twenty-four buffers is further provided. Using the present methods, 14 poorly behaving proteins have been screened, resulting in 11 of the proteins having highly improved dynamic light scattering results allowing concentration of the proteins, and 9 were crystallized.

  1. Getter sputtering system for high-throughput fabrication of composition spreads

    SciTech Connect (OSTI)

    Gregoire, John M.; Dover, R. B. van; Jin Jing; Di Salvo, Francis J.; Abruna, Hector D. [Department of Physics, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States); Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States); Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States)

    2007-07-15T23:59:59.000Z

    We describe a sputtering system that can deposit composition spreads in an effectively UHV environment but which does not require the high-throughput paradigm to be compromised by a long pump down each time a target is changed. The system deploys four magnetron sputter guns in a cryoshroud (getter sputtering) which allows elements such as Ti and Zr to be deposited with minimal contamination by oxygen or other reactive background gases. The system also relies on custom substrate heaters to give rapid heating and cool down. The effectiveness of the gettering technique is evaluated, and example results obtained for catalytic activity of a pseudoternary composition spread are presented.

  2. High throughput ultrasoft x-ray polychromator for embedded impurity pellet injection studies

    SciTech Connect (OSTI)

    Stutman, D.; Finkenthal, M.; Delgado-Aparicio, L.; Tritz, K.; Tamura, N.; Kalinina, D.; Matsubara, A.; Sato, K.; Sudo, S. [Department of Physics and Astronomy, Johns Hopkins University, Baltimore, Maryland 21218 (United States); National Institute for Fusion Science, Oroshi-cho 322-6, Toki 509-5292 (Japan); National Institute for Fusion Science, Oroshi-cho 322-6, Toki 509-5292 (Japan); and Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193 (Japan); National Institute for Fusion Science, Oroshi-cho 322-6, Toki 509-5292 (Japan); National Institute for Fusion Science, Oroshi-cho 322-6, Toki 509-5292 (Japan); and Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193 (Japan)

    2005-01-01T23:59:59.000Z

    A prototype ultrasoft x-ray polychromator has been developed for local particle transport measurements in magnetic fusion devices using the H{sub {alpha}} charge exchange emission from low-Z impurity pellets. High throughput together with few cm radial resolution in the plasma are achieved using a toroidally aligned grid collimator, while a few A spectral bandpass together with strong background rejection are obtained using planar multilayer mirrors and foil filters. As high sensitivity detectors we use a new type of compact, efficient and high-gain multichannel plates. The prototype instrument has been evaluated in the laboratory and tested on the Large Helical Device in Japan. In addition to transport studies, this type of device is of interest for next step experiments, where high beam energy and strong attenuation will make visible charge exchange recombination spectroscopy difficult.

  3. High-Throughput, High-Precision Hot Testing Tool for High-Brightness

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking of Blythe Solar PowerCommercial Cold Climate HeatEnergy

  4. Development of Control Applications for High-Throughput Protein Crystallography Experiments

    SciTech Connect (OSTI)

    Gaponov, Yurii A.; Matsugaki, Naohiro; Honda, Nobuo; Sasajima, Kumiko; Igarashi, Noriyuki; Hiraki, Masahiko; Yamada, Yusuke; Wakatsuki, Soichi [Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, 1-1 Oho, Tsukuba, Ibaraki (Japan)

    2007-01-19T23:59:59.000Z

    An integrated client-server control system (PCCS) with a unified relational database (PCDB) has been developed for high-throughput protein crystallography experiments on synchrotron beamlines. The major steps in protein crystallographic experiments (purification, crystallization, crystal harvesting, data collection, and data processing) are integrated into the software. All information necessary for performing protein crystallography experiments is stored in the PCDB database (except raw X-ray diffraction data, which is stored in the Network File Server). To allow all members of a protein crystallography group to participate in experiments, the system was developed as a multi-user system with secure network access based on TCP/IP secure UNIX sockets. Secure remote access to the system is possible from any operating system with X-terminal and SSH/X11 (Secure Shell with graphical user interface) support. Currently, the system covers the high-throughput X-ray data collection stages and is being commissioned at BL5A and NW12A (PF, PF-AR, KEK, Tsukuba, Japan)

  5. Development of a high-throughput microfluidic integrated microarray for the detection of chimeric bioweapons.

    SciTech Connect (OSTI)

    Sheppod, Timothy; Satterfield, Brent; Hukari, Kyle W.; West, Jason A. A.; Hux, Gary A.

    2006-10-01T23:59:59.000Z

    The advancement of DNA cloning has significantly augmented the potential threat of a focused bioweapon assault, such as a terrorist attack. With current DNA cloning techniques, toxin genes from the most dangerous (but environmentally labile) bacterial or viral organism can now be selected and inserted into robust organism to produce an infinite number of deadly chimeric bioweapons. In order to neutralize such a threat, accurate detection of the expressed toxin genes, rather than classification on strain or genealogical decent of these organisms, is critical. The development of a high-throughput microarray approach will enable the detection of unknowns chimeric bioweapons. The development of a high-throughput microarray approach will enable the detection of unknown bioweapons. We have developed a unique microfluidic approach to capture and concentrate these threat genes (mRNA's) upto a 30 fold concentration. These captured oligonucleotides can then be used to synthesize in situ oligonucleotide copies (cDNA probes) of the captured genes. An integrated microfluidic architecture will enable us to control flows of reagents, perform clean-up steps and finally elute nanoliter volumes of synthesized oligonucleotides probes. The integrated approach has enabled a process where chimeric or conventional bioweapons can rapidly be identified based on their toxic function, rather than being restricted to information that may not identify the critical nature of the threat.

  6. Heterogeneous High Throughput Scientific Computing with APM X-Gene and Intel Xeon Phi

    E-Print Network [OSTI]

    David Abdurachmanov; Brian Bockelman; Peter Elmer; Giulio Eulisse; Robert Knight; Shahzad Muzaffar

    2014-10-10T23:59:59.000Z

    Electrical power requirements will be a constraint on the future growth of Distributed High Throughput Computing (DHTC) as used by High Energy Physics. Performance-per-watt is a critical metric for the evaluation of computer architectures for cost- efficient computing. Additionally, future performance growth will come from heterogeneous, many-core, and high computing density platforms with specialized processors. In this paper, we examine the Intel Xeon Phi Many Integrated Cores (MIC) co-processor and Applied Micro X-Gene ARMv8 64-bit low-power server system-on-a-chip (SoC) solutions for scientific computing applications. We report our experience on software porting, performance and energy efficiency and evaluate the potential for use of such technologies in the context of distributed computing systems such as the Worldwide LHC Computing Grid (WLCG).

  7. Development and operation of a high-throughput accurate-wavelength lens-based spectrometer

    SciTech Connect (OSTI)

    Bell, Ronald E., E-mail: rbell@pppl.gov [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 (United States)

    2014-11-15T23:59:59.000Z

    A high-throughput spectrometer for the 400–820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm{sup ?1} grating is matched with fast f/1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy ?0.075 arc sec. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount at the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  8. Development and Operation of High-throughput Accurate-wavelength Lens-based Spectrometer

    SciTech Connect (OSTI)

    Bell, Ronald E

    2014-07-01T23:59:59.000Z

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy < 0.075 arc seconds. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount behind the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  9. Development and operation of a high-throughput accurate-wavelength lens-based spectrometera)

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Bell, Ronald E. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543, USA

    2014-11-01T23:59:59.000Z

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy < 0.075 arc seconds. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount behind the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  10. Evaluation of the effects of various culture condition on Cr (VI) reduction by Shewanella oneidensis MR-1 in a novel high-throughput mini-bioreactor

    E-Print Network [OSTI]

    Tang, Yinjie J.; Laidlaw, David; Gani, Kishen; Keasling, Jay D.

    2006-01-01T23:59:59.000Z

    high-throughput mini-bioreactor Yinjie Tang †,1 , Davidexamined using a mini-bioreactor system that independentlyreduction. The mini-bioreactor system enabled the rapid

  11. Learning quantitative sequence-function relationships from high-throughput biological data

    E-Print Network [OSTI]

    Atwal, Gurinder S

    2015-01-01T23:59:59.000Z

    Understanding the transcriptional regulatory code, as well as other types of information encoded within biomolecular sequences, will require learning biophysical models of sequence-function relationships from high-throughput data. Controlling and characterizing the noise in such experiments, however, is notoriously difficult. The unpredictability of such noise creates problems for standard likelihood-based methods in statistical learning, which require that the quantitative form of experimental noise be known precisely. However, when this unpredictability is properly accounted for, important theoretical aspects of statistical learning which remain hidden in standard treatments are revealed. Specifically, one finds a close relationship between the standard inference method, based on likelihood, and an alternative inference method based on mutual information. Here we review and extend this relationship. We also describe its implications for learning sequence-function relationships from real biological data. Fin...

  12. Integrated crystal mounting and alignment system for high-throughput biological crystallography

    DOE Patents [OSTI]

    Nordmeyer, Robert A. (San Leandro, CA); Snell, Gyorgy P. (Richmond, CA); Cornell, Earl W. (Antioch, CA); Kolbe, William F. (Moraga, CA); Yegian, Derek T. (Oakland, CA); Earnest, Thomas N. (Berkeley, CA); Jaklevich, Joseph M. (Lafayette, CA); Cork, Carl W. (Walnut Creek, CA); Santarsiero, Bernard D. (Chicago, IL); Stevens, Raymond C. (La Jolla, CA)

    2007-09-25T23:59:59.000Z

    A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.

  13. Integrated crystal mounting and alignment system for high-throughput biological crystallography

    DOE Patents [OSTI]

    Nordmeyer, Robert A.; Snell, Gyorgy P.; Cornell, Earl W.; Kolbe, William; Yegian, Derek; Earnest, Thomas N.; Jaklevic, Joseph M.; Cork, Carl W.; Santarsiero, Bernard D.; Stevens, Raymond C.

    2005-07-19T23:59:59.000Z

    A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.

  14. Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening

    SciTech Connect (OSTI)

    Cuttitta, Christina M. [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); The City University of New York, 2800 Victory Boulevard, Staten Island, NY 10314 (United States); Ericson, Daniel L. [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); University at Buffalo, SUNY, 12 Capen Hall, Buffalo, NY 14260 (United States); Scalia, Alexander [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Binghamton University, 4400 Vestal Parkway East, Binghamton, NY 11973-5000 (United States); Roessler, Christian G. [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Teplitsky, Ella [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Stony Brook University, Stony Brook, NY 11794-5215 (United States); Joshi, Karan [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); PEC University of Technology, Chandigarh (India); Campos, Olven [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33414 (United States); Agarwal, Rakhi; Allaire, Marc [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Orville, Allen M. [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Brookhaven National Laboratory, Upton, NY 11973-5000 (United States); Sweet, Robert M.; Soares, Alexei S., E-mail: soares@bnl.gov [Brookhaven National Laboratory, Upton, NY 11973-5000 (United States)

    2015-01-01T23:59:59.000Z

    An acoustic high-throughput screening method is described for harvesting protein crystals and combining the protein crystals with chemicals such as a fragment library. Acoustic droplet ejection (ADE) is an emerging technology with broad applications in serial crystallography such as growing, improving and manipulating protein crystals. One application of this technology is to gently transfer crystals onto MiTeGen micromeshes with minimal solvent. Once mounted on a micromesh, each crystal can be combined with different chemicals such as crystal-improving additives or a fragment library. Acoustic crystal mounting is fast (2.33 transfers s{sup ?1}) and all transfers occur in a sealed environment that is in vapor equilibrium with the mother liquor. Here, a system is presented to retain crystals near the ejection point and away from the inaccessible dead volume at the bottom of the well by placing the crystals on a concave agarose pedestal (CAP) with the same chemical composition as the crystal mother liquor. The bowl-shaped CAP is impenetrable to crystals. Consequently, gravity will gently move the crystals into the optimal location for acoustic ejection. It is demonstrated that an agarose pedestal of this type is compatible with most commercially available crystallization conditions and that protein crystals are readily transferred from the agarose pedestal onto micromeshes with no loss in diffraction quality. It is also shown that crystals can be grown directly on CAPs, which avoids the need to transfer the crystals from the hanging drop to a CAP. This technology has been used to combine thermolysin and lysozyme crystals with an assortment of anomalously scattering heavy atoms. The results point towards a fast nanolitre method for crystal mounting and high-throughput screening.

  15. An infrared imaging method for high-throughput combinatorial investigation of hydrogenation-dehydrogenation and new phase

    E-Print Network [OSTI]

    Rubloff, Gary W.

    An infrared imaging method for high-throughput combinatorial investigation of hydrogenation Received 9 April 2009; accepted 30 June 2009; published online 30 July 2009 We have developed an infrared imaging setup enabling in situ infrared images to be acquired, and expanded on capabilities of an infrared

  16. Novel mixed polyanions lithium-ion battery cathode materials predicted by high-throughput ab initio computations

    E-Print Network [OSTI]

    Ceder, Gerbrand

    Novel mixed polyanions lithium-ion battery cathode materials predicted by high-throughput ab initio (>700 Wh/kg) cathode materials for lithium-ion batteries. 1 Introduction The widespread use of lithium-ion monoclinic phase).5 However, the field of lithium-ion batteries is very active, and a large number

  17. IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 32, NO. 10, OCTOBER 2013 1791 DevStaR: High-Throughput Quantification

    E-Print Network [OSTI]

    Sontag, Eduardo

    of C. elegans embryonic viability in high-throughput (HTP) applications. A leading genetic model organism for the study of animal development and behavior, C. elegans is particularly amenable to HTP the algorithmic design of the DevStaR system and demonstrate its performance in scoring image data acquired in HTP

  18. A Cross-Referencing-Based Droplet Manipulation Method for High-Throughput and Pin-Constrained Digital Microfluidic Arrays*

    E-Print Network [OSTI]

    Chakrabarty, Krishnendu

    -Constrained Digital Microfluidic Arrays* Tao Xu and Krishnendu Chakrabarty Department of Electrical and Computer Engineering Duke University, Durham, NC 27708, USA {tx, krish}@ee.duke.edu Abstract Digital microfluidic. As high-throughput bioassays are mapped to digital microfluidic platforms, the need for design automation

  19. been the key to their success is the use of high-throughput experiments to assess various zeo-

    E-Print Network [OSTI]

    Silver, Whendee

    it and the resulting pore structure. It could be that the hexamethonium molecules pack in such a way as to providebeen the key to their success is the use of high- throughput experiments to assess various zeo and shape of the resulting pores cor- responds to the size and shape of the organic molecule. ITQ-33

  20. Applications of Artificial Neural Networks and Fuzzy Models in High Throughput Screening: Classifying the activities of various compounds towards Cobalt

    E-Print Network [OSTI]

    Kansas, University of

    Applications of Artificial Neural Networks and Fuzzy Models in High Throughput Screening to the existing HTS method, via Quantitative Structure-Activity Relationship (QSAR) using Artificial Neural in solving non-linear pattern classification problems, we propose several different models of neural networks

  1. High-throughput liquid-absorption air-sampling apparatus and methods

    DOE Patents [OSTI]

    Zaromb, Solomon (95706 William Dr., Hinsdale, IL 60521)

    2000-01-01T23:59:59.000Z

    A portable high-throughput liquid-absorption air sampler [PHTLAAS] has an asymmetric air inlet through which air is drawn upward by a small and light-weight centrifugal fan driven by a direct current motor that can be powered by a battery. The air inlet is so configured as to impart both rotational and downward components of motion to the sampled air near said inlet. The PHTLAAS comprises a glass tube of relatively small size through which air passes at a high rate in a swirling, highly turbulent motion, which facilitates rapid transfer of vapors and particulates to a liquid film covering the inner walls of the tube. The pressure drop through the glass tube is <10 cm of water, usually <5 cm of water. The sampler's collection efficiency is usually >20% for vapors or airborne particulates in the 2-3.mu. range and >50% for particles larger than 4.mu.. In conjunction with various analyzers, the PHTLAAS can serve to monitor a variety of hazardous or illicit airborne substances, such as lead-containing particulates, tritiated water vapor, biological aerosols, or traces of concealed drugs or explosives.

  2. A search model for topological insulators with high-throughput robustness descriptors

    SciTech Connect (OSTI)

    Yang, Kesong; Setyawan, Wahyu; Wang, Shidong; Nardelli, Marco B.; Curtarolo, Stephano

    2012-05-13T23:59:59.000Z

    Topological insulators (TI) are becoming one of the most studied classes of novel materials because of their great potential for applications ranging from spintronics to quantum computers. To fully integrate TI materials in electronic devices, high-quality epitaxial single-crystalline phases with sufficiently large bulk bandgaps are necessary. Current efforts have relied mostly on costly and time-consuming trial-and-error procedures. Here we show that by defining a reliable and accessible descriptor {cflx X}TI, which represents the topological robustness or feasibility of the candidate, and by searching the quantum materials repository aflowlib.org, we have automatically discovered 28 TIs (some of them already known) in five different symmetry families. These include peculiar ternary halides, Cs{l_brace}Sn,Pb,Ge{r_brace}{l_brace}Cl,Br,I{r_brace}{sub 3}, which could have been hardly anticipated without high-throughput means. Our search model, by relying on the significance of repositories in materials development, opens new avenues for the discovery of more TIs in different and unexplored classes of systems.

  3. Metal Organic Framework Research: High Throughput Discovery of Robust Metal Organic Framework for CO2 Capture

    SciTech Connect (OSTI)

    None

    2010-08-01T23:59:59.000Z

    IMPACCT Project: LBNL is developing a method for identifying the best metal organic frameworks for use in capturing CO2 from the flue gas of coal-fired power plants. Metal organic frameworks are porous, crystalline compounds that, based on their chemical structure, vary considerably in terms of their capacity to grab hold of passing CO2 molecules and their ability to withstand the harsh conditions found in the gas exhaust of coal-fired power plants. Owing primarily to their high tunability, metal organic frameworks can have an incredibly wide range of different chemical and physical properties, so identifying the best to use for CO2 capture and storage can be a difficult task. LBNL uses high-throughput instrumentation to analyze nearly 100 materials at a time, screening them for the characteristics that optimize their ability to selectively adsorb CO2 from coal exhaust. Their work will identify the most promising frameworks and accelerate their large-scale commercial development to benefit further research into reducing the cost of CO2 capture and storage.

  4. FBI Fingerprint Image Capture System High-Speed-Front-End throughput modeling

    SciTech Connect (OSTI)

    Rathke, P.M.

    1993-09-01T23:59:59.000Z

    The Federal Bureau of Investigation (FBI) has undertaken a major modernization effort called the Integrated Automated Fingerprint Identification System (IAFISS). This system will provide centralized identification services using automated fingerprint, subject descriptor, mugshot, and document processing. A high-speed Fingerprint Image Capture System (FICS) is under development as part of the IAFIS program. The FICS will capture digital and microfilm images of FBI fingerprint cards for input into a central database. One FICS design supports two front-end scanning subsystems, known as the High-Speed-Front-End (HSFE) and Low-Speed-Front-End, to supply image data to a common data processing subsystem. The production rate of the HSFE is critical to meeting the FBI`s fingerprint card processing schedule. A model of the HSFE has been developed to help identify the issues driving the production rate, assist in the development of component specifications, and guide the evolution of an operations plan. A description of the model development is given, the assumptions are presented, and some HSFE throughput analysis is performed.

  5. VLPW: The Very Long Packet Window Architecture for High Throughput Network-On-Chip Router Designs

    E-Print Network [OSTI]

    Gu, Haiyin

    2012-10-19T23:59:59.000Z

    -chip routers and the ideal interconnect fabric. To improve throughput, VLPW optimizes Switch Allocation (SA) efficiency. Existing SA normally applies Round-Robin scheduling to arbitrate among the packets targeting the same output port. However, this simple...

  6. Integrated Controlling System and Unified Database for High Throughput Protein Crystallography Experiments

    SciTech Connect (OSTI)

    Gaponov, Yu.A.; Igarashi, N.; Hiraki, M.; Sasajima, K.; Matsugaki, N.; Suzuki, M.; Kosuge, T.; Wakatsuki, S. [Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba (Japan)

    2004-05-12T23:59:59.000Z

    An integrated controlling system and a unified database for high throughput protein crystallography experiments have been developed. Main features of protein crystallography experiments (purification, crystallization, crystal harvesting, data collection, data processing) were integrated into the software under development. All information necessary to perform protein crystallography experiments is stored (except raw X-ray data that are stored in a central data server) in a MySQL relational database. The database contains four mutually linked hierarchical trees describing protein crystals, data collection of protein crystal and experimental data processing. A database editor was designed and developed. The editor supports basic database functions to view, create, modify and delete user records in the database. Two search engines were realized: direct search of necessary information in the database and object oriented search. The system is based on TCP/IP secure UNIX sockets with four predefined sending and receiving behaviors, which support communications between all connected servers and clients with remote control functions (creating and modifying data for experimental conditions, data acquisition, viewing experimental data, and performing data processing). Two secure login schemes were designed and developed: a direct method (using the developed Linux clients with secure connection) and an indirect method (using the secure SSL connection using secure X11 support from any operating system with X-terminal and SSH support). A part of the system has been implemented on a new MAD beam line, NW12, at the Photon Factory Advanced Ring for general user experiments.

  7. Bonus Organisms in High-Throughput Eukaryotic Whole-Genome Shorgun Assembly

    SciTech Connect (OSTI)

    Pangilinan, Jasmyn; Shapiro, Harris; Tu, Hank; Platt, Darren

    2006-02-06T23:59:59.000Z

    The DOE Joint Genome Institute has sequenced over 50 eukaryotic genomes, ranging in size from 15 MB to 1.6 GB, over a wide range of organism types. In the course of doing so, it has become clear that a substantial fraction of these data sets contains bonus organisms, usually prokaryotes, in addition to the desired genome. While some of these additional organisms are extraneous contamination, they are sometimes symbionts, and so can be of biological interest. Therefore, it is desirable to assemble the bonus organisms along with the main genome. This transforms the problem into one of metagenomic assembly, which is considerably more challenging than traditional whole-genome shotgun (WGS) assembly. The different organisms will usually be present at different sequence depths, which is difficult to handle in most WGS assemblers. In addition, with multiple distinct genomes present, chimerism can produce cross-organism combinations. Finally, there is no guarantee that only a single bonus organism will be present. For example, one JGI project contained at least two different prokaryotic contaminants, plus a 145 KB plasmid of unknown origin. We have developed techniques to routinely identify and handle such bonus organisms in a high-throughput sequencing environment. Approaches include screening and partitioning the unassembled data, and iterative subassemblies. These methods are applicable not only to bonus organisms, but also to desired components such as organelles. These procedures have the additional benefit of identifying, and allowing for the removal of, cloning artifacts such as E.coli and spurious vector inclusions.

  8. A microreactor array for spatially resolved measurement of catalytic activity for high-throughput catalysis science

    SciTech Connect (OSTI)

    Kondratyuk, Petro; Gumuslu, Gamze; Shukla, Shantanu; Miller, James B.; Morreale, Bryan D.; Gellman, Andrew J.

    2013-04-01T23:59:59.000Z

    We describe a 100 channel microreactor array capable of spatially resolved measurement of catalytic activity across the surface of a flat substrate. When used in conjunction with a composition spread alloy film (CSAF, e.g. Pd{sub x}Cu{sub y}Au{sub 1-x-y}) across which component concentrations vary smoothly, such measurements permit high-throughput analysis of catalytic activity and selectivity as a function of catalyst composition. In the reported implementation, the system achieves spatial resolution of 1 mm{sup 2} over a 10Ś10 mm{sup 2} area. During operation, the reactant gases are delivered at constant flow rate to 100 points of differing composition on the CSAF surface by means of a 100-channel microfluidic device. After coming into contact with the CSAF catalyst surface, the product gas mixture from each of the 100 points is withdrawn separately through a set of 100 isolated channels for analysis using a mass spectrometer. We demonstrate the operation of the device on a Pd{sub x}Cu{sub y}Au{sub 1-x-y} CSAF catalyzing the H{sub 2}-D{sub 2} exchange reaction at 333 K. In essentially a single experiment, we measured the catalytic activity over a broad swathe of concentrations from the ternary composition space of the Pd{sub x}Cu{sub y}Au{sub 1-x-y} alloy.

  9. Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

    SciTech Connect (OSTI)

    Wu, Zhigang; Willing, Ben; Bjerketorp, Joakim; Jansson, Janet K.; Hjort, Klas

    2009-01-05T23:59:59.000Z

    We developed a new approach to separate bacteria from human blood cells based on soft inertial force induced migration with flow defined curved and focused sample flow inside a microfluidic device. This approach relies on a combination of an asymmetrical sheath flow and proper channel geometry to generate a soft inertial force on the sample fluid in the curved and focused sample flow segment to deflect larger particles away while the smaller ones are kept on or near the original flow streamline. The curved and focused sample flow and inertial effect were visualized and verified using a fluorescent dye primed in the device. First the particle behavior was studied in detail using 9.9 and 1.0 {micro}m particles with a polymer-based prototype. The prototype device is compact with an active size of 3 mm{sup 2}. The soft inertial effect and deflection distance were proportional to the fluid Reynolds number (Re) and particle Reynolds number (Re{sub p}), respectively. We successfully demonstrated separation of bacteria (Escherichia coli) from human red blood cells at high cell concentrations (above 10{sup 8}/mL), using a sample flow rate of up to 18 {micro}L/min. This resulted in at least a 300-fold enrichment of bacteria at a wide range of flow rates with a controlled flow spreading. The separated cells were proven to be viable. Proteins from fractions before and after cell separation were analyzed by gel electrophoresis and staining to verify the removal of red blood cell proteins from the bacterial cell fraction. This novel microfluidic process is robust, reproducible, simple to perform, and has a high throughput compared to other cell sorting systems. Microfluidic systems based on these principles could easily be manufactured for clinical laboratory and biomedical applications.

  10. New Composite Membranes for High Throughput Solid-Liquid Separations at the Savannah River Site

    SciTech Connect (OSTI)

    Bhave, Ramesh R [ORNL

    2012-01-01T23:59:59.000Z

    New Composite Membranes for High Throughput Solid-Liquid Separations at the Savannah River Site R. Bhave (Oak Ridge National Laboratory. Oak Ridge, TN) and M. R. Poirier* (Savannah River National Laboratory, Aiken SC) Solid-liquid separation is the limiting step for many waste treatment processes at the Savannah River Site. SRNL researchers have identified the rotary microfilter as a technology to improve the rate of solid-liquid separation processes. SRNL is currently developing the rotary microfilter for radioactive service and plans to deploy the technology as part of the small column ion exchange process. The rotary microfilter can utilize any filter media that is available as a flat sheet. The current baseline membrane is a 0.5 micron (nominal) porous metal filter (Pall PMM050). Previous testing with tubular filters showed that filters composed of a ceramic membrane on top of a stainless steel support produce higher flux than filters composed only of porous metal. The authors are working to develop flat sheet filter media composed of a ceramic membrane and/or ceramic-metal composite on top of a porous stainless steel support that can be used with the rotary microfilter to substantially increase filter flux resulting in a more compact, energy efficient and cost-effective high level radioactive waste treatment system. Composite membranes with precisely controlled pore size distribution were fabricated on porous metal supports. High quality uniform porous metal (316SS) supports were fabricated to achieve high water permeability. Separative layers of several different materials such as ultrafine metal particles and ceramic oxides were used to fabricate composite membranes. The fabrication process involved several high temperature heat treatments followed by characterization of gas and liquid permeability measurements and membrane integrity analysis. The fabricated composite membrane samples were evaluated in a static test cell manufactured by SpinTek. The composite membranes were evaluated on several feed slurries: 1 wt. % strontium carbonate in deionized water, 1 wt. % monosodium titanate in simulated salt solution, and 1 wt. % simulated sludge in simulated salt solution and deionized water. Flux as a function of feed flow rate and transmembrane pressure was measured for each of the above described feed slurries. The authors will discuss the new membrane development efforts, waste slurry filtration performance evaluations and scale-up considerations.

  11. Synthesis and characterization of four new metal 5-phosphonoisophthalates discovered by high-throughput experimentation

    SciTech Connect (OSTI)

    Bauer, Sebastian [Institute of Inorganic Chemistry, Christian-Albrechts-University, Otto-Hahn-Platz 6/7, D 24098 Kiel (Germany); Stock, Norbert [Institute of Inorganic Chemistry, Christian-Albrechts-University, Otto-Hahn-Platz 6/7, D 24098 Kiel (Germany)], E-mail: stock@ac.uni-kiel.de

    2007-11-15T23:59:59.000Z

    A new ligand, 5-diethylphosphonoisophthalic acid ((HOOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}(C{sub 2}H{sub 5}){sub 2}, H{sub 2}Et{sub 2}L), for the hydrothermal synthesis of inorganic-organic hybrid compounds was prepared and characterized by NMR-spectroscopy. Its in situ hydrolysis leads to the corresponding 5-phosphonoisophthalic acid ((HOOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}H{sub 2}, H{sub 4}L). Applying high-throughput methods, different di- and trivalent metal salts for the synthesis of crystalline metal phosphonates based on H{sub 2}Et{sub 2}L have been screened. From the resulting discovery library, single-crystals of four new compounds, [Sm{sub 2}(H{sub 2}O){sub 4}(H(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}){sub 2}].2H{sub 2}O (1), [Cu{sub 3}(H{sub 2}O)(H(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}){sub 2}].2H{sub 2}O (2), Ca{sub 2}(H{sub 2}O)[H(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}H]{sub 2} (3), and Ba{sub 2}(H{sub 2}O){sub 3}(OOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3} (4), have been isolated. The single-crystal structure determination of the title compounds shows H{sub 4}L to be a versatile ligand, exhibiting different types of coordination modes between the functional groups and the metal ions. A comparison of the structural features of the title compounds shows a varying degree of M-O-M connectivities. Thus, isolated metal-oxygen clusters (compounds 1 and 2), infinite M-O-M chains (compound 3), and infinite M-O-M layers (compound 4) are observed. The title compounds 1, 2, and 3 were further characterized by IR-spectroscopy, TG-, EDX-, and elemental chemical analysis. - Graphical abstract: Applying high-throughput methods, the new ligand 5-diethylphosphonoisophtalic acid, (HOOC){sub 2}C{sub 6}H{sub 3}-PO{sub 3}(C{sub 2}H{sub 5}){sub 2} (H{sub 2}Et{sub 2}L), was reacted with several di- and trivalent metal salts under hydrothermal conditions. Single-crystals of four new inorganic-organic hybrid compounds were isolated from the discovery library. The single-crystal structure analysis shows a varying M-O-M connectivity.

  12. RESULTS OF THE FY09 ENHANCED DOE HIGH LEVEL WASTE MELTER THROUGHPUT STUDIES AT SRNL

    SciTech Connect (OSTI)

    Johnson, F.; Edwards, T.

    2010-06-23T23:59:59.000Z

    High-level waste (HLW) throughput (i.e., the amount of waste processed per unit time) is a function of two critical parameters: waste loading (WL) and melt rate. For the Waste Treatment and Immobilization Plant (WTP) at the Hanford Site and the Defense Waste Processing Facility (DWPF) at the Savannah River Site (SRS), increasing HLW throughput would significantly reduce the overall mission life cycle costs for the Department of Energy (DOE). The objective of this task is to develop data, assess property models, and refine or develop the necessary models to support increased WL of HLW at SRS. It is a continuation of the studies initiated in FY07, but is under the specific guidance of a Task Change Request (TCR)/Work Authorization received from DOE headquarters (Project Number RV071301). Using the data generated in FY07, FY08 and historical data, two test matrices (60 glasses total) were developed at the Savannah River National Laboratory (SRNL) in order to generate data in broader compositional regions. These glasses were fabricated and characterized using chemical composition analysis, X-ray Diffraction (XRD), viscosity, liquidus temperature (TL) measurement and durability as defined by the Product Consistency Test (PCT). The results of this study are summarized below: (1) In general, the current durability model predicts the durabilities of higher waste loading glasses quite well. A few of the glasses exhibited poorer durability than predicted. (2) Some of the glasses exhibited anomalous behavior with respect to durability (normalized leachate for boron (NL [B])). The quenched samples of FY09EM21-02, -07 and -21 contained no nepheline or other wasteform affecting crystals, but have unacceptable NL [B] values (> 10 g/L). The ccc sample of FY09EM21-07 has a NL [B] value that is more than one half the value of the quenched sample. These glasses also have lower concentrations of Al{sub 2}O{sub 3} and SiO{sub 2}. (3) Five of the ccc samples (EM-13, -14, -15, -29 and -30) completely crystallized with both magnetite and nepheline, and still had extremely low NL [B] values. These particular glasses have more CaO present than any of the other glasses in the matrix. It appears that while all of the glasses contain nepheline, the NL [B] values decrease as the CaO concentration increases from 2.3 wt% to 4.3 wt%. A different form of nepheline may be created at higher concentrations of CaO that does not significantly reduce glass durability. (4) The T{sub L} model appears to be under-predicting the measured values of higher waste loading glasses. Trends in T{sub L} with composition are not evident in the data from these studies. (5) A small number of glasses in the FY09 matrix have measured viscosities that are much lower than the viscosity range over which the current model was developed. The decrease in viscosity is due to a higher concentration of non-bridging oxygens (NBO). A high iron concentration is the cause of the increase in NBO. Durability, viscosity and T{sub L} data collected during FY07 and FY09 that specifically targeted higher waste loading glasses was compiled and assessed. It appears that additional data may be required to expand the coverage of the T{sub L} and viscosity models for higher waste loading glasses. In general, the compositional regions of the higher waste loading glasses are very different than those used to develop these models. On the other hand, the current durability model seems to be applicable to the new data. At this time, there is no evidence to modify this model; however additional experimental studies should be conducted to determine the cause of the anomalous durability data.

  13. Distribution System Analysis Tools for Studying High Penetration of PV

    E-Print Network [OSTI]

    Distribution System Analysis Tools for Studying High Penetration of PV with Grid Support Features Electric Energy System #12;#12;Distribution System Analysis Tools for Studying High Penetration of PV project titled "Distribution System Analysis Tools for Studying High Penetration of PV with Grid Support

  14. High-throughput two-hybrid analysis The promise and the peril

    E-Print Network [OSTI]

    Dunham, Maitreya

    , reduction in reagent costs and further refinements of the approach. As throughput escalates, so does use. The first stage is the initial description of a method: the prototype version. Typically. For a large fraction of new technologies, few other examples beyond this proto- type are ever described

  15. Throughput analysis for MIMO systems in the high SNR regime Narayan Prasad and Mahesh K. Varanasi

    E-Print Network [OSTI]

    Varanasi, Mahesh K.

    . The throughputs of MISO and SIMO fading channels are extensively analyzed and it is shown that asymptoti- cally [1, 2] and is defined as the maximum rate that can be transmitted reliably over all channel realiza rate which can be reliably transmitted This work was supported in part by NSF Grant CCF-0431170

  16. On-chip whole-animal manipulation for high-throughput subcellular-resolution in-vivo drug/genetic screening

    E-Print Network [OSTI]

    Yanik, Mehmet Fatih

    Techniques for rapid and automated small-animal manipulation and immobilization are necessary for high-throughput in vivo genetic/drug screens using cellular and sub-cellular features in multicellular organisms. We present ...

  17. New Challenges of the Computation of Multiple Sequence Alignments in the High-Throughput Era (2010 JGI/ANL HPC Workshop)

    ScienceCinema (OSTI)

    Notredame, Cedric [Centre for Genomic Regulation

    2011-06-08T23:59:59.000Z

    Cedric Notredame from the Centre for Genomic Regulation gives a presentation on "New Challenges of the Computation of Multiple Sequence Alignments in the High-Throughput Era" at the JGI/Argonne HPC Workshop on January 26, 2010.

  18. Vehicle Technologies Office Merit Review 2015: High-Throughput Study of Diffusion and Phase Transformation Kinetics of Magnesium-Based Systems For Automotive Cast Magnesium Alloys

    Broader source: Energy.gov [DOE]

    Presentation given by Ohio State University at 2015 DOE Hydrogen and Fuel Cells Program and Vehicle Technologies Office Annual Merit Review and Peer Evaluation Meeting about high-throughput study...

  19. Assessment of advanced coal-gasification processes. [AVCO high throughput gasification in process; Bell High Mass Flux process; CS-R process; and Exxon Gasification process

    SciTech Connect (OSTI)

    McCarthy, J.; Ferrall, J.; Charng, T.; Houseman, J.

    1981-06-01T23:59:59.000Z

    This report represents a technical assessment of the following advanced coal gasification processes: AVCO High Throughput Gasification (HTG) Process, Bell Single - Stage High Mass Flux (HMF) Process, Cities Service/Rockwell (CS/R) Hydrogasification Process, and the Exxon Catalytic Coal Gasification (CCG) Process. Each process is evaluated for its potential to produce SNG from a bituminous coal. In addition to identifying the new technology these processes represent, key similarities/differences, strengths/weaknesses, and potential improvements to each process are identified. The AVCO HTG and the Bell HMF gasifiers share similarities with respect to: short residence time (SRT), high throughput rate, slagging and syngas as the initial raw product gas. The CS/R Hydrogasifier is also SRT but is non-slagging and produces a raw gas high in methane content. The Exxon CCG gasifier is a long residence time, catalytic fluidbed reactor producing all of the raw product methane in the gasifier.

  20. Advanced Environments and Tools for High Performance Computing

    E-Print Network [OSTI]

    Walker, David W.

    Advanced Environments and Tools for High Performance Computing Problem-Solving Environments Environments and Tools for High Performance Computing. The conference was chaired by Professor D. W. Walker and managing distributed high performance comput- ing resources is important for a PSE to meet the requirements

  1. Feasibility and Design Studies for a High Temperature Downhole Tool

    Broader source: Energy.gov [DOE]

    Project objective: Perform feasibility and design studies for a high temperature downhole tool; which uses nuclear techniques for characterization purposes; using measurements and modeling/simulation.

  2. High-throughput characterization of stresses in thin film materials libraries using Si cantilever array wafers and digital holographic microscopy

    SciTech Connect (OSTI)

    Lai, Y. W.; Ludwig, A. [Institute for Materials, Chair for Materials for Microsystems, Ruhr-Universitaet Bochum, 44780 Bochum (Germany); Materials Research Department, Ruhr-Universitaet Bochum, 44780 Bochum (Germany); Hamann, S.; Ehmann, M. [Institute for Materials, Chair for Materials for Microsystems, Ruhr-Universitaet Bochum, 44780 Bochum (Germany)

    2011-06-15T23:59:59.000Z

    We report the development of an advanced high-throughput stress characterization method for thin film materials libraries sputter-deposited on micro-machined cantilever arrays consisting of around 1500 cantilevers on 4-inch silicon-on-insulator wafers. A low-cost custom-designed digital holographic microscope (DHM) is employed to simultaneously monitor the thin film thickness, the surface topography and the curvature of each of the cantilevers before and after deposition. The variation in stress state across the thin film materials library is then calculated by Stoney's equation based on the obtained radii of curvature of the cantilevers and film thicknesses. DHM with nanometer-scale out-of-plane resolution allows stress measurements in a wide range, at least from several MPa to several GPa. By using an automatic x-y translation stage, the local stresses within a 4-inch materials library are mapped with high accuracy within 10 min. The speed of measurement is greatly improved compared with the prior laser scanning approach that needs more than an hour of measuring time. A high-throughput stress measurement of an as-deposited Fe-Pd-W materials library was evaluated for demonstration. The fast characterization method is expected to accelerate the development of (functional) thin films, e.g., (magnetic) shape memory materials, whose functionality is greatly stress dependent.

  3. RECENT PROCESS AND EQUIPMENT IMPROVEMENTS TO INCREASE HIGH LEVEL WASTE THROUGHPUT AT THE DEFENSE WASTE PROCESSING FACILITY

    SciTech Connect (OSTI)

    Odriscoll, R; Allan Barnes, A; Jim Coleman, J; Timothy Glover, T; Robert Hopkins, R; Dan Iverson, D; Jeff Leita, J

    2008-01-15T23:59:59.000Z

    The Savannah River Site's (SRS) Defense Waste Processing Facility (DWPF) began stabilizing high level waste (HLW) in a glass matrix in 1996. Over the past few years, there have been several process and equipment improvements at the DWPF to increase the rate at which the high level waste can be stabilized. These improvements have either directly increased waste processing rates or have desensitized the process to upsets, thereby minimizing downtime and increasing production. Improvements due to optimization of waste throughput with increased HLW loading of the glass resulted in a 6% waste throughput increase based upon operational efficiencies. Improvements in canister production include the pour spout heated bellows liner (5%), glass surge (siphon) protection software (2%), melter feed pump software logic change to prevent spurious interlocks of the feed pump with subsequent dilution of feed stock (2%) and optimization of the steam atomized scrubber (SAS) operation to minimize downtime (3%) for a total increase in canister production of 12%. A number of process recovery efforts have allowed continued operation. These include the off gas system pluggage and restoration, slurry mix evaporator (SME) tank repair and replacement, remote cleaning of melter top head center nozzle, remote melter internal inspection, SAS pump J-Tube recovery, inadvertent pour scenario resolutions, dome heater transformer bus bar cooling water leak repair and new Infra-red camera for determination of glass height in the canister are discussed.

  4. automated high-throughput screening: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    requires rapid screening methods.3 One powerful is a powerful tool for functional genomics research and is also discussed as a potential therapeutic strategy.6 Quake, Stephen...

  5. Geochip: A high throughput genomic tool for linking community structure to functions

    E-Print Network [OSTI]

    Van Nostrand, Joy D.

    2009-01-01T23:59:59.000Z

    soil samples from two oilfields, Daqing and Shengli, locatedall samples from the Daqing oilfield grouping together whilecommunity from the Shengli oilfield was separate (Figure 2),

  6. High-throughput experimental and computational tools for exploring immunity and the microbiome

    E-Print Network [OSTI]

    Papa, Eliseo

    2012-01-01T23:59:59.000Z

    Humans live in association with trillions of microbes and yet we know remarkably little about their symbiotic relationship. The role these microorganisms have in humans has been characterized only in the case of few bacteria ...

  7. Algorithms and tools for high-throughput geometry-based analysis of

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem NotEnergy,ARMForms About BecomeTechnologies | Blandine Jerome

  8. High-throughput, dual probe biological assays based on single molecule detection

    DOE Patents [OSTI]

    Hollars, Christopher W. (Brentwood, CA); Huser, Thomas R. (Livermore, CA); Lane, Stephen M. (Oakland, CA); Balhorn, Rodney L. (Livermore, CA); Bakajin, Olgica (San Leandro, CA); Darrow, Christopher (Pleasanton, CA); Satcher, Jr., Joe H. (Patterson, CA)

    2006-07-11T23:59:59.000Z

    A method and apparatus with the sensitivity to detect and identify single target molecules through the localization of dual, fluorescently labeled probe molecules. This can be accomplished through specific attachment of the taget to a surface or in a two-dimensional (2D) flowing fluid sheet having approximate dimensions of 0.5 .mu.m.times.100 .mu.m.times.100 .mu.m. A device using these methods would have 10.sup.3 10.sup.4 greater throughput than previous one-dimensional (1D) micro-stream devices having 1 .mu.m.sup.3 interrogation volumes and would for the first time allow immuno- and DNA assays at ultra-low (femtomolar) concentrations to be performed in short time periods (.about.10 minutes). The use of novel labels (such as metal or semiconductor nanoparticles) may be incorporated to further extend the sensitivity possibly into the attomolar range.

  9. Advancing the High Throughput Identification of Liver Fibrosis Protein Signatures Using Multiplexed Ion Mobility Spectrometry

    SciTech Connect (OSTI)

    Baker, Erin Shammel; Burnum-Johnson, Kristin E.; Jacobs, Jon M.; Diamond, Deborah L.; Brown, Roslyn N.; Ibrahim, Yehia M.; Orton, Daniel J.; Piehowski, Paul D.; Purdy, David E.; Moore, Ronald J.; Danielson, William F.; Monroe, Matthew E.; Crowell, Kevin L.; Slysz, Gordon W.; Gritsenko, Marina A.; Sandoval, John D.; Lamarche, Brian L.; Matzke, Melissa M.; Webb-Robertson, Bobbie-Jo M.; Simons, Brenna C.; McMahon, Brian J.; Bhattacharya, Renuka; Perkins, James D.; Carithers, Robert L.; Strom, Susan; Self, Steven; Katze, Michael G.; Anderson, Gordon A.; Smith, Richard D.

    2014-04-01T23:59:59.000Z

    Rapid diagnosis of disease states using less invasive, safer, and more clinically acceptable approaches than presently employed is an imperative goal for the field of medicine. While mass spectrometry (MS)-based proteomics approaches have attempted to meet these objectives, challenges such as the enormous dynamic range of protein concentrations in clinically relevant biofluid samples coupled with the need to address human biodiversity have slowed their employment. Herein, we report on the use of a new platform that addresses these challenges by coupling technical advances in rapid gas phase multiplexed ion mobility spectrometry (IMS) separations [1, 2] with liquid chromatography (LC) and MS to dramatically increase measurement sensitivity and throughput, further enabling future MS-based clinical applications. An initial application of the LC-IMS-MS platform for the analysis of blood serum samples from stratified post-liver transplant patients with recurrent fibrosis progression illustrates its potential utility for disease characterization and use in personalized medicine [3, 4].

  10. Operations capability improvement of a molecular biology laboratory in a high throughput genome sequencing center

    E-Print Network [OSTI]

    Vokoun, Matthew R. (Matthew Richard)

    2005-01-01T23:59:59.000Z

    The Broad Institute is a research collaboration of MIT, Harvard University and affiliated hospitals, and the Whitehead Institute for Biomedical Research. Its scientific mission is to "(1) create tools for genomic medicine ...

  11. Now available at the DNA Sequencing and Genotyping Core Facility OpenArray High-throughput nanofluidic PCR technology

    E-Print Network [OSTI]

    Ruvinsky, Ilya

    -throughput nanofluidic PCR technology from Life Technologies/Applied Biosystems Application/ Service Area Types · Experimental flexibility ­ open-format layout · Nanofluidic design reduces reagent usage Questions? Contact

  12. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

    2014-01-01T23:59:59.000Z

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: • A novel computational framework was developed for mechanistic study of SADRs. • Off-targets of drugs were identified in large scale and in a high-throughput manner. • SADRs like cardiac disorders were systematically explored in molecular networks. • A number of ADR-associated proteins were identified.

  13. High power laser perforating tools and systems

    DOE Patents [OSTI]

    Zediker, Mark S; Rinzler, Charles C; Faircloth, Brian O; Koblick, Yeshaya; Moxley, Joel F

    2014-04-22T23:59:59.000Z

    ystems devices and methods for the transmission of 1 kW or more of laser energy deep into the earth and for the suppression of associated nonlinear phenomena. Systems, devices and methods for the laser perforation of a borehole in the earth. These systems can deliver high power laser energy down a deep borehole, while maintaining the high power to perforate such boreholes.

  14. Quantifying the source of reentrant line variability and the effects of processes standardization on tool availability variability

    E-Print Network [OSTI]

    Peavey, Milo Camp

    2007-01-01T23:59:59.000Z

    This thesis quantifies the sensitivity of tool availability variability with respect to product throughput and examines how Intel's High Precision Maintenance initiative can be used to minimize these effects. Tools with ...

  15. A General Framework for Development and Data Analysis of Competitive High-Throughput Screens for Small-Molecule Inhibitors of Protein-Protein

    E-Print Network [OSTI]

    ). Recent advances in chemical biology and high-throughput (HTP)1 screening (13-15) have introduced the use sensitive, robust, and widely used HTP methods for the study of protein interactions and drug discovery (19, can serve as a sensitive molecular sensor. HTP FP assays usually detect changes in polarization caused

  16. automated high-throughput platform: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of the Geniom Biochip for specific elongation and labeling Cai, Long 52 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites...

  17. array-based high throughput: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roehm, Uwe 2009-01-01 13 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...

  18. aureus strains high-throughput: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roehm, Uwe 2009-01-01 14 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...

  19. antileishmanial high-throughput drug: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roehm, Uwe 2009-01-01 22 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...

  20. Technology assessment and feasibility study of high-throughput single cell force spectroscopy

    E-Print Network [OSTI]

    Cheng, He, M. Eng. Massachusetts Institute of Technology

    2010-01-01T23:59:59.000Z

    In the last decade, the field of single cell mechanics has emerged with the development of high resolution experimental and computational methods, providing significant amount of information about individual cells instead ...

  1. On-the-fly machine-learning for high-throughput experiments: search for rare-earth-free permanent magnets

    SciTech Connect (OSTI)

    Kusne, Aaron Gilad [University of Maryland; Gao, Tieren [University of Maryland; Mehta, Apurva [SLAC National Accelerator Laboratory; Ke, Liqin [Ames Laboratory; Nguyen, Manh Cuong [Ames Laboratory; Ho, Kai-Ming [Ames Laboratory; Antropov, Vladimir [Ames Laboratory; Wang, Cai-Zhuang [Ames Laboratory; Kramer, Matthew J [Ames Laboratory; Long, Christian [University of Maryland; Takeuchi, Ichiro [University of Maryland

    2014-09-15T23:59:59.000Z

    Advanced materials characterization techniques with ever-growing data acquisition speed and storage capabilities represent a challenge in modern materials science, and new procedures to quickly assess and analyze the data are needed. Machine learning approaches are effective in reducing the complexity of data and rapidly homing in on the underlying trend in multi-dimensional data. Here, we show that by employing an algorithm called the mean shift theory to a large amount of diffraction data in high-throughput experimentation, one can streamline the process of delineating the structural evolution across compositional variations mapped on combinatorial libraries with minimal computational cost. Data collected at a synchrotron beamline are analyzed on the fly, and by integrating experimental data with the inorganic crystal structure database (ICSD), we can substantially enhance the accuracy in classifying the structural phases across ternary phase spaces. We have used this approach to identify a novel magnetic phase with enhanced magnetic anisotropy which is a candidate for rare-earth free permanent magnet.

  2. Air-stable ink for scalable, high-throughput layer deposition

    DOE Patents [OSTI]

    Weil, Benjamin D; Connor, Stephen T; Cui, Yi

    2014-02-11T23:59:59.000Z

    A method for producing and depositing air-stable, easily decomposable, vulcanized ink on any of a wide range of substrates is disclosed. The ink enables high-volume production of optoelectronic and/or electronic devices using scalable production methods, such as roll-to-roll transfer, fast rolling processes, and the like.

  3. Structural inference of native and partially folded RNA by high-throughput contact mapping

    E-Print Network [OSTI]

    Herschlag, Dan

    of the P4­P6 RNA that is stabilized by high concentrations of monovalent salt and whose partial order to the dynamic but otherwise similar molten globule states of proteins. With its applicability to nearly any of large RNA molecules and RNA/protein complexes. hydroxyl radical molten globule Tetrahymena ribozyme two

  4. High-throughput detection of ethanol-producing cyanobacteria in a microdroplet platform

    E-Print Network [OSTI]

    Abalde-Cela, Sara; Gould, Anna; Liu, Xin; Kazamia, Elena; Smith, Alison G.; Abell, Chris

    2015-03-17T23:59:59.000Z

    crops such as maize or sugar cane [2]. In particular, bioethanol is emerging as one of the most promising non-fossil energy resources, due to its abil- ity to be a ‘drop-in’ fuel mixed with gasoline (petrol). However, bioethanol production from sugars... obtained from arable crops requires high land areas to meet the energy requirements and so competes with land for food production. As a consequence, the need for alternative bioethanol producers is a critical issue in the biofuel field [3,4]. Microalgae...

  5. High throughput lessons from the LHC experience.Johnston.TNC2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm) Harmonicbet WhenHiggs BosonAccurate knowledgeHighHighhigh

  6. Improved Algae-based Biorefining and High-throughput Screening of Algal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOEThe Bonneville PowerCherries 82981-1cnHigh School footballHydrogenIT |HotImpact ofVisiting20143101 101

  7. High-Throughput Methodology for Discovery of Metal-Organic Frameworks with

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a rDepartment ofofa High Binding

  8. High-Throughput Program for the Discovery of NOx Reduction Catalysts |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a rDepartment ofofa High

  9. High-Throughput Genetic Analysis and Combinatorial Chiral Separations Based on Capillary Electrophoresis

    SciTech Connect (OSTI)

    Wenwan Zhong

    2003-08-05T23:59:59.000Z

    Capillary electrophoresis (CE) offers many advantages over conventional analytical methods, such as speed, simplicity, high resolution, low cost, and small sample consumption, especially for the separation of enantiomers. However, chiral method developments still can be time consuming and tedious. They designed a comprehensive enantioseparation protocol employing neutral and sulfated cyclodextrins as chiral selectors for common basic, neutral, and acidic compounds with a 96-capillary array system. By using only four judiciously chosen separation buffers, successful enantioseparations were achieved for 49 out of 54 test compounds spanning a large variety of pKs and structures. Therefore, unknown compounds can be screened in this manner to identify optimal enantioselective conditions in just one rn. In addition to superior separation efficiency for small molecules, CE is also the most powerful technique for DNA separations. Using the same multiplexed capillary system with UV absorption detection, the sequence of a short DNA template can be acquired without any dye-labels. Two internal standards were utilized to adjust the migration time variations among capillaries, so that the four electropherograms for the A, T, C, G Sanger reactions can be aligned and base calling can be completed with a high level of confidence. the CE separation of DNA can be applied to study differential gene expression as well. Combined with pattern recognition techniques, small variations among electropherograms obtained by the separation of cDNA fragments produced from the total RNA samples of different human tissues can be revealed. These variations reflect the differences in total RNA expression among tissues. Thus, this Ce-based approach can serve as an alternative to the DNA array techniques in gene expression analysis.

  10. High Throughput Sample Preparation and Analysis for DNA Sequencing, PCR and Combinatorial Screening of Catalysis Based on Capillary Array Technique

    SciTech Connect (OSTI)

    Yonghua Zhang

    2002-05-27T23:59:59.000Z

    Sample preparation has been one of the major bottlenecks for many high throughput analyses. The purpose of this research was to develop new sample preparation and integration approach for DNA sequencing, PCR based DNA analysis and combinatorial screening of homogeneous catalysis based on multiplexed capillary electrophoresis with laser induced fluorescence or imaging UV absorption detection. The author first introduced a method to integrate the front-end tasks to DNA capillary-array sequencers. protocols for directly sequencing the plasmids from a single bacterial colony in fused-silica capillaries were developed. After the colony was picked, lysis was accomplished in situ in the plastic sample tube using either a thermocycler or heating block. Upon heating, the plasmids were released while chromsomal DNA and membrane proteins were denatured and precipitated to the bottom of the tube. After adding enzyme and Sanger reagents, the resulting solution was aspirated into the reaction capillaries by a syringe pump, and cycle sequencing was initiated. No deleterious effect upon the reaction efficiency, the on-line purification system, or the capillary electrophoresis separation was observed, even though the crude lysate was used as the template. Multiplexed on-line DNA sequencing data from 8 parallel channels allowed base calling up to 620 bp with an accuracy of 98%. The entire system can be automatically regenerated for repeated operation. For PCR based DNA analysis, they demonstrated that capillary electrophoresis with UV detection can be used for DNA analysis starting from clinical sample without purification. After PCR reaction using cheek cell, blood or HIV-1 gag DNA, the reaction mixtures was injected into the capillary either on-line or off-line by base stacking. The protocol was also applied to capillary array electrophoresis. The use of cheaper detection, and the elimination of purification of DNA sample before or after PCR reaction, will make this approach an attractive alternative to current methods for genetic analysis and disease diagnosis.

  11. Robofurnace: A semi-automated laboratory chemical vapor deposition system for high-throughput nanomaterial synthesis and process discovery

    SciTech Connect (OSTI)

    Oliver, C. Ryan; Westrick, William; Koehler, Jeremy; Brieland-Shoultz, Anna; Anagnostopoulos-Politis, Ilias; Cruz-Gonzalez, Tizoc [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States)] [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Hart, A. John, E-mail: ajhart@mit.edu [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

    2013-11-15T23:59:59.000Z

    Laboratory research and development on new materials, such as nanostructured thin films, often utilizes manual equipment such as tube furnaces due to its relatively low cost and ease of setup. However, these systems can be prone to inconsistent outcomes due to variations in standard operating procedures and limitations in performance such as heating and cooling rates restrict the parameter space that can be explored. Perhaps more importantly, maximization of research throughput and the successful and efficient translation of materials processing knowledge to production-scale systems, relies on the attainment of consistent outcomes. In response to this need, we present a semi-automated lab-scale chemical vapor deposition (CVD) furnace system, called “Robofurnace.” Robofurnace is an automated CVD system built around a standard tube furnace, which automates sample insertion and removal and uses motion of the furnace to achieve rapid heating and cooling. The system has a 10-sample magazine and motorized transfer arm, which isolates the samples from the lab atmosphere and enables highly repeatable placement of the sample within the tube. The system is designed to enable continuous operation of the CVD reactor, with asynchronous loading/unloading of samples. To demonstrate its performance, Robofurnace is used to develop a rapid CVD recipe for carbon nanotube (CNT) forest growth, achieving a 10-fold improvement in CNT forest mass density compared to a benchmark recipe using a manual tube furnace. In the long run, multiple systems like Robofurnace may be linked to share data among laboratories by methods such as Twitter. Our hope is Robofurnace and like automation will enable machine learning to optimize and discover relationships in complex material synthesis processes.

  12. High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons

    E-Print Network [OSTI]

    Nieland, Thomas J.

    The formation of synapses, the specialized points of chemical communication between neurons, is a highly regulated developmental process fundamental to establishing normal brain circuitry. Perturbations of synapse formation ...

  13. An Innovative High-Temperature High-Pressure Measurement While Drilling (MWD) Tool

    SciTech Connect (OSTI)

    Brian Boling

    2007-06-01T23:59:59.000Z

    Measurement while drilling (MWD) tools specified to 150 C (302 F) that provide wellbore surveys, real-time inclination, and natural gamma ray detection are a commodity item in the oilfield services industry. MWD tools specified to 175 C (347 F) that routinely demonstrate highly reliable operation are available from only a few service companies. Commercial MWD tools that reliably operate to 200 C (392 F) for extended periods of time and offer features like real-time gamma ray, retrievability, and reseatability are nonexistent. Need for these higher temperature tools will increase as wells become hotter in the search for new oil and gas resources. The goal of this project was to design a retrievable and reseatable high-pressure/high-temperature MWD tool with real-time continuous inclination, vibration detection, annular pressure, and gamma ray detection. This report describes the development of such a tool from concept, through feasibility, and into field testing and preliminary development planning. It describes the challenges encountered in the design of the tool, along with testing results and decisions about the commercial viability of the tool in the configuration in which it was developed. The decision was made not to commercialize the tool developed under this project because of a combination of battery technology problems and modulation power consumption at the required depths.

  14. High Throughput, Low Toxic Processing of Very Thin, High Efficiency CIGSS Solar Cells: Final Report, December 2008

    SciTech Connect (OSTI)

    Dhere, N. G.

    2009-04-01T23:59:59.000Z

    The work carried out during this project presents the use of diethylselenium or other organometallic precursors as low-toxicity alternative selenium sources for preparing a high-quality absorber.

  15. Beyond differential expression : methods and tools for mining the transcriptomic landscape of human tissue and disease

    E-Print Network [OSTI]

    Schmid, Patrick R. (Patrick Raphael)

    2012-01-01T23:59:59.000Z

    Although there are a variety of high-throughput technologies used to perform biological experiments, DNA microarrays have become a standard tool in the modern biologist's arsenal. Microarray experiments provide measurements ...

  16. Miniaturized Analytical Platforms From Nanoparticle Components: Studies in the Construction, Characterization, and High-Throughput Usage of These Novel Architectures

    SciTech Connect (OSTI)

    Andrew David Pris

    2003-08-05T23:59:59.000Z

    The scientific community has recently experienced an overall effort to reduce the physical size of many experimental components to the nanometer size range. This size is unique as the characteristics of this regime involve aspects of pure physics, biology, and chemistry. One extensively studied example of a nanometer sized experimental component, which acts as a junction between these three principle scientific theologies, is deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). These biopolymers not only contain the biological genetic guide to code for the production of life-sustaining materials, but are also being probed by physicists as a means to create electrical circuits and furthermore as controllable architectural and sensor motifs in the chemical disciplines. Possibly the most common nano-sized component between these sciences are nanoparticles composed of a variety of materials. The cross discipline employment of nanoparticles is evident from the vast amount of literature that has been produced from each of the individual communities within the last decade. Along these cross-discipline lines, this dissertation examines the use of several different types of nanoparticles with a wide array of surface chemistries to understand their adsorption properties and to construct unique miniaturized analytical and immunoassay platforms. This introduction will act as a literature review to provide key information regarding the synthesis and surface chemistries of several types of nanoparticles. This material will set the stage for a discussion of assembling ordered arrays of nanoparticles into functional platforms, architectures, and sensors. The introduction will also include a short explanation of the atomic force microscope that is used throughout the thesis to characterize the nanoparticle-based structures. Following the Introduction, four research chapters are presented as separate manuscripts. Chapter 1 examines the self-assembly of polymeric nanoparticles exhibiting a variety of surface chemistries and attempts to deconvolute general adsorption rules for their assembly on various substrates. Chapter 2 extends the usage of self-assembly of polymeric nanoparticles through a layer-by-layer deposition concept and photolithography methodologies to create analytical platforms with a vertical height controlled within the nanometer regime. This platform is then furthered in Chapter 3 by employing this integrated concept as a bio-recognition platform, with the extension of the method to a high-throughput screening system explored. Chapter 4 exploits two different types of nanoparticles, silica and gold, as multiplexed, self-assembled immunoassay sensors. This final research chapter is followed by a general summation and future prospectus section that concludes the dissertation.

  17. Nanocoatings for High-Efficiency Industrial Hydraulic and Tooling Systems

    SciTech Connect (OSTI)

    Clifton B. Higdon III

    2011-01-07T23:59:59.000Z

    Industrial manufacturing in the U.S. accounts for roughly one third of the 98 quadrillion Btu total energy consumption. Motor system losses amount to 1.3 quadrillion Btu, which represents the largest proportional loss of any end-use category, while pumps alone represent over 574 trillion BTU (TBTU) of energy loss each year. The efficiency of machines with moving components is a function of the amount of energy lost to heat because of friction between contacting surfaces. The friction between these interfaces also contributes to downtime and the loss of productivity through component wear and subsequent repair. The production of new replacement parts requires additional energy. Among efforts to reduce energy losses, wear-resistant, low-friction coatings on rotating and sliding components offer a promising approach that is fully compatible with existing equipment and processes. In addition to lubrication, one of the most desirable solutions is to apply a protective coating or surface treatment to rotating or sliding components to reduce their friction coefficients, thereby leading to reduced wear. Historically, a number of materials such as diamond-like carbon (DLC), titanium nitride (TiN), titanium aluminum nitride (TiAlN), and tungsten carbide (WC) have been examined as tribological coatings. The primary objective of this project was the development of a variety of thin film nanocoatings, derived from the AlMgB14 system, with a focus on reducing wear and friction in both industrial hydraulics and cutting tool applications. Proof-of-concept studies leading up to this project had shown that the constituent phases, AlMgB14 and TiB2, were capable of producing low-friction coatings by pulsed laser deposition. These coatings combine high hardness with a low friction coefficient, and were shown to substantially reduce wear in laboratory tribology tests. Selection of the two applications was based largely on the concept of improved mechanical interface efficiencies for energy conservation. In mobile hydraulic systems, efficiency gains through low friction would translate into improved fuel economy and fewer greenhouse gas emissions. Stationary hydraulic systems, accordingly, would consume less electrical power. Reduced tooling wear in machining operations would translate to greater operating yields, while lowering the energy consumed during processing. The AlMgB14 nanocoatings technology progressed beyond baseline laboratory tests into measurable energy savings and enhancements to product durability. Three key hydraulic markets were identified over the course of the project that will benefit from implementation: industrial vane pumps, orbiting valve-in-star hydraulic motors, and variable displacement piston pumps. In the vane pump application, the overall product efficiency was improved by as much as 11%. Similar results were observed with the hydraulic motors tested, where efficiency gains of over 10% were noted. For variable displacement piston pumps, overall efficiency was improved by 5%. For cutting tools, the most significant gains in productivity (and, accordingly, the efficiency of the machining process as a whole) were associated with the roughing and finishing of titanium components for aerospace systems. Use of the AlMgB14 nanocoating in customer field tests has shown that the coated tools were able to withstand machining rates as high as 500sfm (limited only by the substrate material), with relatively low flank wear when compared to other industrial offerings. AlMgB14 coated tools exhibited a 60% improvement over similarly applied TiAlN thin films. Furthermore, AlMgB14-based coatings in these particular tests lasted twice as long than their TiAlN counterparts at the 500sfm feed rates. Full implementation of the technology into the industrial hydraulic and cutting tool markets equates to a worldwide energy savings of 46 trillion BTU/year by 2030. U.S.-based GHG emissions associated with the markets identified would fall accordingly, dropping by as much as 50,000 tonnes annually.

  18. Development of new tools and applications for high-throughput sequencing of microbiomes in environmental or clinical samples

    E-Print Network [OSTI]

    Blackburn, Matthew Christopher

    2010-01-01T23:59:59.000Z

    Novel sequencing technologies are rapidly advancing studies of microbial community structure and diversity. Sequencing platforms like the Illumina Genome Analyzer II (GAI1) and the Applied Biosystems SOLiD enable experiments ...

  19. HiTSEE: A Visualization Tool for Hit Selection and Analysis in High-Throughput Screening Experiments

    E-Print Network [OSTI]

    Deussen, Oliver

    importantly the lack of temporal control required to study dynamic processes, since a protein cannot be turned a cellular system and to elucidate the function of proteins. As genes encode proteins, gene function can be modu- lated through a mutation, which in turn perturbs the function of the protein of interest

  20. High-Tech Tools for Teaching Physics: the Physics Education Technology Project

    E-Print Network [OSTI]

    Colorado at Boulder, University of

    MS #06-020 High-Tech Tools for Teaching Physics: the Physics Education Technology Project Noah Teaching and Learning September 15, 2006 #12;MS #06-020 High-Tech Tools for Teaching Physics: the Physics the Physics Education Technology (PhET) project, identifies features of these educational tools

  1. Six-flow operations for catalyst development in Fischer-Tropsch synthesis: Bridging the gap between high-throughput experimentation and extensive product evaluation

    SciTech Connect (OSTI)

    Sartipi, Sina, E-mail: S.Sartipi@tudelft.nl, E-mail: J.Gascon@tudelft.nl; Jansma, Harrie; Bosma, Duco; Boshuizen, Bart; Makkee, Michiel; Gascon, Jorge, E-mail: S.Sartipi@tudelft.nl, E-mail: J.Gascon@tudelft.nl; Kapteijn, Freek [Department of Chemical Engineering, Catalysis Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft (Netherlands)] [Department of Chemical Engineering, Catalysis Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft (Netherlands)

    2013-12-15T23:59:59.000Z

    Design and operation of a “six-flow fixed-bed microreactor” setup for Fischer-Tropsch synthesis (FTS) is described. The unit consists of feed and mixing, flow division, reaction, separation, and analysis sections. The reactor system is made of five heating blocks with individual temperature controllers, assuring an identical isothermal zone of at least 10 cm along six fixed-bed microreactor inserts (4?mm inner diameter). Such a lab-scale setup allows running six experiments in parallel, under equal feed composition, reaction temperature, and conditions of separation and analysis equipment. It permits separate collection of wax and liquid samples (from each flow line), allowing operation with high productivities of C5+ hydrocarbons. The latter is crucial for a complete understanding of FTS product compositions and will represent an advantage over high-throughput setups with more than ten flows where such instrumental considerations lead to elevated equipment volume, cost, and operation complexity. The identical performance (of the six flows) under similar reaction conditions was assured by testing a same catalyst batch, loaded in all microreactors.

  2. General High Performance Adaptive Robust Motion Control of Machine Tools Mohammed Al-Majed++

    E-Print Network [OSTI]

    Yao, Bin

    the advantages and improved performance obtained via the ARC design. I. Introduction Modern mechanical systems,4] is applied to the high performance motion control of machine tools to make the resulting closed-loop systemGeneral High Performance Adaptive Robust Motion Control of Machine Tools Bin Yao + Mohammed Al

  3. Nonendocytic Delivery of Functional Engineered Nanoparticles into the Cytoplasm of Live Cells Using a Novel, High-Throughput Microfluidic Device

    E-Print Network [OSTI]

    Lee, Jungmin

    The ability to straightforwardly deliver engineered nanoparticles into the cell cytosol with high viability will vastly expand the range of biological applications. Nanoparticles could potentially be used as delivery ...

  4. A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus

    E-Print Network [OSTI]

    Chung, Dong-Hoon; Moore, Blake P.; Matharu, Daljit S.; Golden, Jennifer E.; Maddox, Clinton; Rasmussen, Lynn; Sosa, Melinda I.; Ananthan, Subramaniam; White, E. Lucile; Jia, Fuli; Jonsson, Colleen B.; Severson, William E.

    2013-01-10T23:59:59.000Z

    Background: Human respiratory syncytial virus (hRSV) is a highly contagious pathogen and is the most common cause of bronchiolitis and pneumonia for infants and children under one year of age. Worldwide, greater than 33 ...

  5. CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells

    E-Print Network [OSTI]

    Ge, Jing

    DNA damaging agents can promote aging, disease and cancer and they are ubiquitous in the environment and produced within human cells as normal cellular metabolites. Ironically, at high doses DNA damaging agents are also ...

  6. A NOVEL LOW THERMAL BUDGET THIN-FILM POLYSILICON FABRICATION PROCESS FOR LARGE-AREA, HIGH-THROUGHPUT SOLAR CELL PRODUCTION

    SciTech Connect (OSTI)

    Yue Kuo

    2010-08-15T23:59:59.000Z

    A novel thin-film poly-Si fabrication process has been demonstrated. This low thermal budget process transforms the single- and multi-layer amorphous silicon thin films into a poly-Si structure in one simple step over a pulsed rapid thermal annealing process with the enhancement of an ultrathin Ni layer. The complete poly-Si solar cell was fabricated in a short period of time without deteriorating the underneath glass substrate. The unique vertical crystallization process including the mechanism is discussed. Influences of the dopant type and process parameters on crystal structure will be revealed. The poly-Si film structure has been proved using TEM, XRD, Raman, and XPS methods. The poly-Si solar cell structure and the performance have been examined. In principle, the new process is potentially applicable to produce large-area thin-film poly-Si solar cells at a high throughput and low cost. A critical issue in this process is to prevent the excessive dopant diffusion during crystallization. Process parameters and the cell structure have to be optimized to achieve the production goal.

  7. Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods

    SciTech Connect (OSTI)

    Lewis, Amanda; Zhao, Hongbin; Hopkins, Scott

    2014-09-30T23:59:59.000Z

    This report summarizes the work completed under the U.S. Department of Energy Project Award No.: DE-FE0001181 titled “Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods.” The project started in October 1, 2009 and was finished September 30, 2014. Pall Corporation worked with Cornell University to sputter and test palladium-based ternary alloys onto silicon wafers to examine many alloys at once. With the specialized equipment at Georgia Institute of Technology that analyzed the wafers for adsorbed carbon and sulfur species six compositions were identified to have resistance to carbon and sulfur species. These compositions were deposited on Pall AccuSepź supports by Colorado School of Mines and then tested in simulated synthetic coal gas at the Pall Corporation. Two of the six alloys were chosen for further investigations based on their performance. Alloy reproducibility and long-term testing of PdAuAg and PdZrAu provided insight to the ability to manufacture these compositions for testing. PdAuAg is the most promising alloy found in this work based on the fabrication reproducibility and resistance to carbon and sulfur. Although PdZrAu had great initial resistance to carbon and sulfur species, the alloy composition has a very narrow range that hindered testing reproducibility.

  8. High-Temperature Downhole Tools | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are8COaBulkTransmissionSitingProcess.pdfGetecGtel Jump to: navigation, search Name:HidraliaWellsDownhole Tools Jump to:

  9. Nanocoatings for High-Efficiency Industrial and Tooling Systems

    SciTech Connect (OSTI)

    Blau, P; Qu, J.; Higdon, C. (Eaton Corporation)

    2011-02-01T23:59:59.000Z

    This industry-driven project was the result of a successful response by Eaton Corporation to a DOE/ITP Program industry call. It consisted of three phases in which ORNL participated. In addition to Eaton Corporation and ORNL (CRADA), the project team included Ames Laboratory, who developed the underlying concept for aluminum-magnesium-boron based nanocomposite coatings [1], and Greenleaf, a small tooling manufacturer in western Pennsylvania. This report focuses on the portion of this work that was conducted by ORNL in a CRADA with Eaton Corporation. A comprehensive final report for the entire effort, which ended in September 2010, has been prepared by Eaton Corporation. Phase I, “Proof of Concept” ran for one year (September 1, 2006 to September 30, 2007) during which the applicability of AlMgB14 single-phase and nanocomposite coatings on hydraulic material coupons and components as well as on tool inserts was demonstrated.. The coating processes used either plasma laser deposition (PLD) or physical vapor deposition (PVD). During Phase I, ORNL conducted laboratory-scale pin-on-disk and reciprocating pin-on-flat tests of coatings produced by PLD and PVD. Non-coated M2 tool steel was used as a baseline for comparison, and the material for the sliding counterface was Type 52100 bearing steel since it simulated the pump materials. Initial tests were run mainly in a commercial hydraulic fluid named Mobil DTE-24, but some tests were later run in a water-glycol mixture as well. A tribosystem analysis was conducted to define the operating conditions of pump components and to help develop simulative tests in Phase II. Phase II, “Coating Process Scale-up” was intended to use scaled-up process to generate prototype parts. This involved both PLD practices at Ames Lab, and a PVD scale-up study at Eaton using its production capable equipment. There was also a limited scale-up study at Greenleaf for the tooling application. ORNL continued to conduct friction and wear tests on process variants and developed tests to better simulate the applications of interest. ORNL also employed existing lubrication models to better understand hydraulic pump frictional behavior and test results. Phase III, “Functional Testing” focused on finalizing the strategy for commercialization of AlMgB14 coatings for both hydraulic and tooling systems. ORNL continued to provide tribology testing and analysis support for hydraulic pump applications. It included both laboratory-scale coupon testing and the analysis of friction and wear data from full component-level tests performed at Eaton Corp. Laboratory-scale tribology test methods are used to characterize the behavior of nanocomposite coatings prior to running them in full-sized hydraulic pumps. This task also includes developing tribosystems analyses, both to provide a better understanding of the performance of coated surfaces in alternate hydraulic fluids, and to help design useful laboratory protocols. Analysis also includes modeling the lubrication conditions and identifying the physical processes by which wear and friction of the contact interface changes over time. This final report summarizes ORNL’s portion of the nanocomposite coatings development effort and presents both generated data and the analyses that were used in the course of this effort.

  10. BioSAXS Sample Changer: a robotic sample changer for rapid and reliable high-throughput X-ray solution scattering experiments

    SciTech Connect (OSTI)

    Round, Adam, E-mail: around@embl.fr; Felisaz, Franck [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Université Grenoble Alpes–EMBL–CNRS, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Fodinger, Lukas; Gobbo, Alexandre [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Huet, Julien [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Université Grenoble Alpes–EMBL–CNRS, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Villard, Cyril [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Blanchet, Clement E., E-mail: around@embl.fr [EMBL c/o DESY, Notkestrasse 85, 22603 Hamburg (Germany); Pernot, Petra; McSweeney, Sean [ESRF, 6 Rue Jules Horowitz, 38000 Grenoble (France); Roessle, Manfred; Svergun, Dmitri I. [EMBL c/o DESY, Notkestrasse 85, 22603 Hamburg (Germany); Cipriani, Florent, E-mail: around@embl.fr [European Molecular Biology Laboratory, Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France); Université Grenoble Alpes–EMBL–CNRS, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble (France)

    2015-01-01T23:59:59.000Z

    A robotic sample changer for solution X-ray scattering experiments optimized for speed and to use the minimum amount of material has been developed. This system is now in routine use at three high-brilliance European synchrotron sites, each capable of several hundred measurements per day. Small-angle X-ray scattering (SAXS) of macromolecules in solution is in increasing demand by an ever more diverse research community, both academic and industrial. To better serve user needs, and to allow automated and high-throughput operation, a sample changer (BioSAXS Sample Changer) that is able to perform unattended measurements of up to several hundred samples per day has been developed. The Sample Changer is able to handle and expose sample volumes of down to 5 ”l with a measurement/cleaning cycle of under 1 min. The samples are stored in standard 96-well plates and the data are collected in a vacuum-mounted capillary with automated positioning of the solution in the X-ray beam. Fast and efficient capillary cleaning avoids cross-contamination and ensures reproducibility of the measurements. Independent temperature control for the well storage and for the measurement capillary allows the samples to be kept cool while still collecting data at physiological temperatures. The Sample Changer has been installed at three major third-generation synchrotrons: on the BM29 beamline at the European Synchrotron Radiation Facility (ESRF), the P12 beamline at the PETRA-III synchrotron (EMBL@PETRA-III) and the I22/B21 beamlines at Diamond Light Source, with the latter being the first commercial unit supplied by Bruker ASC.

  11. High power laser workover and completion tools and systems

    DOE Patents [OSTI]

    Zediker, Mark S; Rinzler, Charles C; Faircloth, Brian O; Koblick, Yeshaya; Moxley, Joel F

    2014-10-28T23:59:59.000Z

    Workover and completion systems, devices and methods for utilizing 10 kW or more laser energy transmitted deep into the earth with the suppression of associated nonlinear phenomena. Systems and devices for the laser workover and completion of a borehole in the earth. These systems and devices can deliver high power laser energy down a deep borehole, while maintaining the high power to perform laser workover and completion operations in such boreholes deep within the earth.

  12. High bandwidth rotary fast tool servos and a hybrid rotary/linear electromagnetic actuator

    E-Print Network [OSTI]

    Montesanti, Richard Clement

    2005-01-01T23:59:59.000Z

    This thesis describes the development of two high bandwidth short-stroke rotary fast tool servos and the hybrid rotary/linear electromagnetic actuator developed for one of them. Design insights, trade-off methodologies, ...

  13. High-Throughput Plasmonic Nanolithography

    E-Print Network [OSTI]

    Pan, Liang

    2010-01-01T23:59:59.000Z

    heating Module..FH Control and Resist Pre-heating Module Inspired by thecontrol and resist pre-heating module using the same laser

  14. High-Throughput Plasmonic Nanolithography

    E-Print Network [OSTI]

    Pan, Liang

    2010-01-01T23:59:59.000Z

    optical near field from a bowtie aperture. Applied PhysicsUtilizing the near- field of bowtie optical nanoantennas.H-shaped, I-shaped and bowtie apertures. Although the

  15. High Energy Colliders as Tools to Understand the Early Universe

    SciTech Connect (OSTI)

    Tait, Tim (ANL) [ANL

    2008-08-16T23:59:59.000Z

    Cosmological observations have reached a new era of precision, and reveal many interesting and puzzling features of the Universe. I will briefly review two of the most exciting mysteries: the nature of the dark components of the Universe, and the origin of the asymmetry between matter and anti-matter. I will argue that our best hope of unraveling these questions will need to combine information from the heavens with measurements in the lab at high energy particle accelerators. The end of run II of the Tevatron, the up-coming Large Hadron Collider and proposed International Linear Collider all have great potential to help us answer these questions in the near future.

  16. Improved Modeling Tools Development for High Penetration Solar

    SciTech Connect (OSTI)

    Washom, Byron

    2014-12-11T23:59:59.000Z

    One of the significant objectives of the High Penetration solar research is to help the DOE understand, anticipate, and minimize grid operation impacts as more solar resources are added to the electric power system. For Task 2.2, an effective, reliable approach to predicting solar energy availability for energy generation forecasts using the University of California, San Diego (UCSD) Sky Imager technology has been demonstrated. Granular cloud and ramp forecasts for the next 5 to 20 minutes over an area of 10 square miles were developed. Sky images taken every 30 seconds are processed to determine cloud locations and cloud motion vectors yielding future cloud shadow locations respective to distributed generation or utility solar power plants in the area. The performance of the method depends on cloud characteristics. On days with more advective cloud conditions, the developed method outperforms persistence forecasts by up to 30% (based on mean absolute error). On days with dynamic conditions, the method performs worse than persistence. Sky Imagers hold promise for ramp forecasting and ramp mitigation in conjunction with inverter controls and energy storage. The pre-commercial Sky Imager solar forecasting algorithm was documented with licensing information and was a Sunshot website highlight

  17. www.emsl.pnnl.gov New Decade, New Tools, New Science: SyStemS biology

    E-Print Network [OSTI]

    , including high-throughput genomics, transcriptomics, proteomics, and metabolomics analyses as well as high

  18. Driving Down HB-LED Costs: Implementation of Process Simulation Tools and Temperature Control Methods of High Yield MOCVD Growth

    SciTech Connect (OSTI)

    William Quinn

    2012-04-30T23:59:59.000Z

    The overall objective of this multi-faceted program is to develop epitaxial growth systems that meet a goal of 75% (4X) cost reduction in the epitaxy phase of HB-LED manufacture. A 75% reduction in yielded epitaxy cost is necessary in order to achieve the cost goals for widespread penetration of HB-LEDâ??s into back-lighting units (BLU) for LCD panels and ultimately for solid-state lighting (SSL). To do this, the program will address significant improvements in overall equipment Cost of Ownership, or CoO. CoO is a model that includes all costs associated with the epitaxy portion of production. These aspects include cost of yield, capital cost, operational costs, and maintenance costs. We divide the program into three phases where later phases will incorporate the gains of prior phases. Phase one activities are enabling technologies. In collaboration with Sandia National Laboratories we develop a Fluent-compatible chemistry predictive model and a set of mid-infrared and near-ultraviolet pyrometer monitoring tools. Where previously the modeling of the reactor dynamics were studied within FLUENT alone, here, FLUENT and Chemkin are integrated into a comprehensive model of fluid dynamics and the most advanced transport equations developed for Chemkin. Specifically, the Chemkin model offered the key reaction terms for gas-phase nucleation, a key consideration in the optimization of the MOCVD process. This new predictive model is used to design new MOCVD reactors with optimized growth conditions and the newly developed pyrometers are used monitor and control the MOCVD process temperature to within 0.5°C run-to-run and within each wafer. This portion of the grant is in collaboration with partners at Sandia National Laboratories. Phase two activities are continuous improvement projects which extend the current reactor platform along the lines of improved operational efficiency, improved systems control for throughput, and carrier modifications for increased yield. Programmatically, improvements made in Phase I are applied to developments of Phase II when applicable. Phase three is the culmination of the individual tasks from both phases one and two applied to proposed production platforms. We selectively combine previously demonstrated tasks and other options to develop a high-volume production-worthy MOCVD system demonstrating >3x throughput, 1.3x capital efficiency, and 0.7x cost of ownership. In a parallel demonstration we validate the concept of an improved, larger deposition system which utilizes the predictive modeling of chemistry-based flow analysis and extensions of the improvements demonstrated on the current platforms. This validation includes the build and testing of a prototype version of the hardware and demonstration of 69% reduction in the cost of ownership. Also, in this phase we present a stand-alone project to develop a high-temperature system which improves source efficiency by 30% while concurrently increasing growth rate by 1.3x. The material quality is held to the same material quality specifications of our existing baseline processes. The merits of other line item tasks in phase three are discussed for inclusion on next-generation platforms.

  19. GeoChip 3.0 as a high-thoughput tool for analyzing microbial community composition, structure, and functional activity

    SciTech Connect (OSTI)

    He, Z.; Deng, Y.; Van Nostrand, J.D.; Tu, Q.; Xu, M.; Hemme, C.L.; Li, X.; Wu, L.; Gentry, T.J.; Yin, Y.; Liebich, J.; Hazen, T.C.; Zhou, J.

    2010-04-01T23:59:59.000Z

    A new generation of functional gene arrays (FGAs; GeoChip 3.0) has been developed, with {approx}28,000 probes covering approximately 57,000 gene variants from 292 functional gene families involved in carbon, nitrogen, phosphorus and sulfur cycles, energy metabolism, antibiotic resistance, metal resistance and organic contaminant degradation. GeoChip 3.0 also has several other distinct features, such as a common oligo reference standard (CORS) for data normalization and comparison, a software package for data management and future updating and the gyrB gene for phylogenetic analysis. Computational evaluation of probe specificity indicated that all designed probes would have a high specificity to their corresponding targets. Experimental analysis with synthesized oligonucleotides and genomic DNAs showed that only 0.0036-0.025% false-positive rates were observed, suggesting that the designed probes are highly specific under the experimental conditions examined. In addition, GeoChip 3.0 was applied to analyze soil microbial communities in a multifactor grassland ecosystem in Minnesota, USA, which showed that the structure, composition and potential activity of soil microbial communities significantly changed with the plant species diversity. As expected, GeoChip 3.0 is a high-throughput powerful tool for studying microbial community functional structure, and linking microbial communities to ecosystem processes and functioning.

  20. Unsteady, high Reynolds number validation cases for a multi-phase CFD analysis tool have been

    E-Print Network [OSTI]

    Kunz, Robert Francis

    and constituent volume fraction transport/generation for liquid, condensable vapor and non-condensable gas fields1 Abstract Unsteady, high Reynolds number validation cases for a multi-phase CFD analysis tool have of the effect of cavitation number, Reynolds number and turbulence model has been made. Analysis of the modeled

  1. CgWind: A high-order accurate simulation tool for wind turbines and wind farms

    SciTech Connect (OSTI)

    Chand, K K; Henshaw, W D; Lundquist, K A; Singer, M A

    2010-02-22T23:59:59.000Z

    CgWind is a high-fidelity large eddy simulation (LES) tool designed to meet the modeling needs of wind turbine and wind park engineers. This tool combines several advanced computational technologies in order to model accurately the complex and dynamic nature of wind energy applications. The composite grid approach provides high-quality structured grids for the efficient implementation of high-order accurate discretizations of the incompressible Navier-Stokes equations. Composite grids also provide a natural mechanism for modeling bodies in relative motion and complex geometry. Advanced algorithms such as matrix-free multigrid, compact discretizations and approximate factorization will allow CgWind to perform highly resolved calculations efficiently on a wide class of computing resources. Also in development are nonlinear LES subgrid-scale models required to simulate the many interacting scales present in large wind turbine applications. This paper outlines our approach, the current status of CgWind and future development plans.

  2. Challenges in the development of high-fidelity LWR core neutronics tools

    SciTech Connect (OSTI)

    Smith, K.; Forget, B. [Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge MA 02139 (United States)

    2013-07-01T23:59:59.000Z

    Modern computing has made possible the solution of extremely large-scale reactor simulations, and the literature has numerous examples of high-resolution methods (often Monte Carlo) applied to full-core reactor problems. However, there are currently no examples in the literature of application of such 'High-Fidelity' or 'First Principles' methods to operating Light Water Reactor (LWR) analysis. This paper seeks to remind code developers, project managers, and analysts of the many important aspects of LWR simulation that must be incorporated to produce truly high-fidelity analysis tools. The authors offer a monetary prize to the first person (or group) that successfully solves a new two-cycle operational PWR depletion benchmark problem using high-fidelity tools and demonstrates acceptable accuracy by comparison with measured operational plant data (open source) provided to the reactor analysis community. (authors)

  3. Acts -- A collection of high performing software tools for scientific computing

    SciTech Connect (OSTI)

    Drummond, L.A.; Marques, O.A.

    2002-11-01T23:59:59.000Z

    During the past decades there has been a continuous growth in the number of physical and societal problems that have been successfully studied and solved by means of computational modeling and simulation. Further, many new discoveries depend on high performance computer simulations to satisfy their demands for large computational resources and short response time. The Advanced CompuTational Software (ACTS) Collection brings together a number of general-purpose computational tool development projects funded and supported by the U.S. Department of Energy (DOE). These tools make it easier for scientific code developers to write high performance applications for parallel computers. They tackle a number of computational issues that are common to a large number of scientific applications, mainly implementation of numerical algorithms, and support for code development, execution and optimization. The ACTS collection promotes code portability, reusability, reduction of duplicate efforts, and tool maturity. This paper presents a brief introduction to the functionality available in ACTS. It also highlight the tools that are in demand by Climate and Weather modelers.

  4. SOWFA Super-Controller: A High-Fidelity Tool for Evaluating Wind Plant Control Approaches

    SciTech Connect (OSTI)

    Fleming, P.; Gebraad, P.; van Wingerden, J. W.; Lee, S.; Churchfield, M.; Scholbrock, A.; Michalakes, J.; Johnson, K.; Moriarty, P.

    2013-01-01T23:59:59.000Z

    This paper presents a new tool for testing wind plant controllers in the Simulator for Offshore Wind Farm Applications (SOWFA). SOWFA is a high-fidelity simulator for the interaction between wind turbine dynamics and the fluid flow in a wind plant. The new super-controller testing environment in SOWFA allows for the implementation of the majority of the wind plant control strategies proposed in the literature.

  5. Capillary Flow Layer-by-Layer: A Microfluidic Platform for the High-Throughput Assembly and Screening of Nanolayered Film Libraries

    E-Print Network [OSTI]

    Castleberry, Steven A.

    Layer-by-layer (LbL) assembly is a powerful tool with increasing real world applications in energy, biomaterials, active surfaces, and membranes; however, the current state of the art requires individual sample construction ...

  6. Cleanup and Dismantling of Highly Contaminated Ventilation Systems Using Robotic Tools - 13162

    SciTech Connect (OSTI)

    Chambon, Frederic [AREVA FEDERAL SERVICES, Columbia MD (United States)] [AREVA FEDERAL SERVICES, Columbia MD (United States); CIZEL, Jean-Pierre [AREVA BE/NV, Marcoule (France)] [AREVA BE/NV, Marcoule (France); Blanchard, Samuel [CEA DEN/DPAD, Marcoule (France)] [CEA DEN/DPAD, Marcoule (France)

    2013-07-01T23:59:59.000Z

    The UP1 plant reprocessed nearly 20,000 tons of used natural uranium gas cooled reactor fuel coming from the first generation of civil nuclear reactors in France. Following operating incidents in the eighties, the ventilation system of the continuous dissolution line facility was shut down and replaced. Two types of remote controlled tool carriers were developed to perform the decontamination and dismantling operations of the highly contaminated ventilation duct network. The first one, a dedicated small robot, was designed from scratch to retrieve a thick powder deposit within a duct. The robot, managed and confined by two dedicated glove boxes, was equipped for intervention inside the ventilation duct and used for carrying various cleanup and inspection tools. The second type, consisting of robotic tools developed on the base of an industrial platform, was used for the clean-up and dismantling of the ventilation duct system. Depending on the type of work to be performed, on the shape constraints of the rooms and any equipment to be dismantled, different kinds of robotic tools were developed and installed on a Brokk 40 carrier. After more than ten years of ventilation duct D and D operations at the UP1 plant, a lot of experience was acquired about remote operations. The three main important lessons learned in terms of remote controlled operation are: characterizing the initial conditions as much as reasonably possible, performing non-radioactive full scale testing and making it as simple and modular as possible. (authors)

  7. A High Performance Computing Platform for Performing High-Volume Studies With Windows-based Power Grid Tools

    SciTech Connect (OSTI)

    Chen, Yousu; Huang, Zhenyu

    2014-08-31T23:59:59.000Z

    Serial Windows-based programs are widely used in power utilities. For applications that require high volume simulations, the single CPU runtime can be on the order of days or weeks. The lengthy runtime, along with the availability of low cost hardware, is leading utilities to seriously consider High Performance Computing (HPC) techniques. However, the vast majority of the HPC computers are still Linux-based and many HPC applications have been custom developed external to the core simulation engine without consideration for ease of use. This has created a technical gap for applying HPC-based tools to today’s power grid studies. To fill this gap and accelerate the acceptance and adoption of HPC for power grid applications, this paper presents a prototype of generic HPC platform for running Windows-based power grid programs on Linux-based HPC environment. The preliminary results show that the runtime can be reduced from weeks to hours to improve work efficiency.

  8. Development of a high-temperature diagnostics-while-drilling tool.

    SciTech Connect (OSTI)

    Chavira, David J.; Huey, David (Stress Engineering Services, Inc.); Hetmaniak, Chris (Stress Engineering Services, Inc.); Polsky, Yarom; King, Dennis K.; Jacobson, Ronald David; Blankenship, Douglas Alan; Knudsen, Steven Dell; Henfling, Joseph Anthony; Mansure, Arthur James

    2009-01-01T23:59:59.000Z

    The envisioned benefits of Diagnostics-While-Drilling (DWD) are based on the principle that high-speed, real-time information from the downhole environment will promote better control of the drilling process. Although in practice a DWD system could provide information related to any aspect of exploration and production of subsurface resources, the current DWD system provides data on drilling dynamics. This particular set of new tools provided by DWD will allow quicker detection of problems, reduce drilling flat-time and facilitate more efficient drilling (drilling optimization) with the overarching result of decreased drilling costs. In addition to providing the driller with an improved, real-time picture of the drilling conditions downhole, data generated from DWD systems provides researchers with valuable, high fidelity data sets necessary for developing and validating enhanced understanding of the drilling process. Toward this end, the availability of DWD creates a synergy with other Sandia Geothermal programs, such as the hard-rock bit program, where the introduction of alternative rock-reduction technologies are contingent on the reduction or elimination of damaging dynamic effects. More detailed descriptions of the rationale for the program and early development efforts are described in more detail by others [SAND2003-2069 and SAND2000-0239]. A first-generation low-temperature (LT) DWD system was fielded in a series of proof-of-concept tests (POC) to validate functionality. Using the LT system, DWD was subsequently used to support a single-laboratory/multiple-partner CRADA (Cooperative Research and Development Agreement) entitled Advanced Drag Bits for Hard-Rock Drilling. The drag-bit CRADA was established between Sandia and four bit companies, and involved testing of a PDC bit from each company [Wise, et al., 2003, 2004] in the same lithologic interval at the Gas Technology Institute (GTI) test facility near Catoosa, OK. In addition, the LT DWD system has been fielded in cost-sharing efforts with an industrial partner to support the development of new generation hard-rock drag bits. Following the demonstrated success of the POC DWD system, efforts were initiated in FY05 to design, fabricate and test a high-temperature (HT) capable version of the DWD system. The design temperature for the HT DWD system was 225 C. Programmatic requirements dictated that a HT DWD tool be developed during FY05 and that a working system be demonstrated before the end of FY05. During initial design discussions regarding a high-temperature system it was decided that, to the extent possible, the HT DWD system would maintain functionality similar to the low temperature system, that is, the HT DWD system would also be designed to provide the driller with real-time information on bit and bottom-hole-assembly (BHA) dynamics while drilling. Additionally, because of time and fiscal constraints associated with the HT system development, the design of the HT DWD tool would follow that of the LT tool. The downhole electronics package would be contained in a concentrically located pressure barrel and the use of externally applied strain gages with thru-tool connectors would also be used in the new design. Also, in order to maximize the potential wells available for the HT DWD system and to allow better comparison with the low-temperature design, the diameter of the tool was maintained at 7-inches. This report discusses the efforts associated with the development of a DWD system capable of sustained operation at 225 C. This report documents work performed in the second phase of the Diagnostics-While-Drilling (DWD) project in which a high-temperature (HT) version of the phase 1 low-temperature (LT) proof-of-concept (POC) DWD tool was built and tested. Descriptions of the design, fabrication and field testing of the HT tool are provided. Background on prior phases of the project can be found in SAND2003-2069 and SAND2000-0239.

  9. Methanol masers as tools to study high-mass star formation

    E-Print Network [OSTI]

    Michele Pestalozzi

    2007-04-23T23:59:59.000Z

    In this contribution I will attempt to show that the study of galactic 6.7 and 12.2GHz methanol masers themselves, as opposed to the use of methanol masers as signposts, can yield important conclusions contributing to the understanding of high-mass star formation. Due to their exclusive association with star formation, methanol masers are the best tools to do this, and their large number allows to probe the entire Galaxy. In particular I will focus on the determination of the luminosity function of methanol masers and on the determination of an unambiguous signature for a circumstellar masing disc seen edge-on. Finally I will try to point out some future fields of research in the study of methanol masers.

  10. gEMpicker: A Highly Parallel GPU-Accelerated Particle Picking Tool for Cryo-Electron Microscopy

    E-Print Network [OSTI]

    Boyer, Edmond

    gEMpicker: A Highly Parallel GPU-Accelerated Particle Picking Tool for Cryo-Electron Microscopy Abstract Background: Picking images of particles in cryo-electron micrographs is an important step particle images. Thus, a computational bottleneck in reaching high resolution is the accurate and automatic

  11. Unconventional Architectures for High-Throughput Sciences

    SciTech Connect (OSTI)

    Nieplocha, Jarek; Marquez, Andres; Petrini, Fabrizio; Chavarría-Miranda, Daniel

    2007-06-15T23:59:59.000Z

    Science laboratories and sophisticated simulations are producing data of increasing volumes and complexities, and that’s posing significant challenges to current data infrastructures as terabytes to petabytes of data must be processed and analyzed. Traditional computing platforms, originally designed to support model-driven applications, are unable to meet the demands of the data-intensive scientific applications. Pacific Northwest National Laboratory (PNNL) research goes beyond “traditional supercomputing” applications to address emerging problems that need scalable, real-time solutions. The outcome is new unconventional architectures for data-intensive applications specifically designed to process the deluge of scientific data, including FPGAs, multithreaded architectures and IBM's Cell.

  12. High throughput liquid absorption preconcentrator sampling instrument

    DOE Patents [OSTI]

    Zaromb, Solomon (Hinsdale, IL); Bozen, Ralph M. (Hattiesburg, MS)

    1992-01-01T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis.

  13. High-Throughput and Combinatorial Screening

    E-Print Network [OSTI]

    , for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL Hydride + H2 Complex Hydride Boride + Binary Hydride + H2 Metal Borohydride We can test six samples per vessel design complete ­ 15 sample hotplates, 3 gas detectors Achieve sample temperatures of 1200 K and H

  14. A High-Throughput Macromolecule Characterization System

    E-Print Network [OSTI]

    Kim, Jae Hyun

    2013-08-31T23:59:59.000Z

    stability of macromolecules in response to various environmental perturbations. Numerous proteins and macromolecular complexes have been analyzed by EPDs to summarize results from large data sets from multiple biophysical techniques. The current EPD method...

  15. High throughput liquid absorption preconcentrator sampling instrument

    DOE Patents [OSTI]

    Zaromb, S.; Bozen, R.M.

    1992-12-22T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis. 12 figs.

  16. High throughput solar cell ablation system

    DOE Patents [OSTI]

    Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John

    2012-09-11T23:59:59.000Z

    A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.

  17. High throughput solar cell ablation system

    DOE Patents [OSTI]

    Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John

    2014-10-14T23:59:59.000Z

    A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.

  18. DOE Workshop HIGH THROUGHPUT/COMBINATORIAL SCREENING

    E-Print Network [OSTI]

    Properties Characterization · Optical/Electronic Materials · Vapor Phase Thin-Film Synthesis · Solution Phase Library Synthesis · HT Materials Characterization · HT Device Fabrication and Performance Evaluation #12/displays, materials for digital radiography, inorganic and organic OLEDs, TCOs Electronics Applications semiconductors

  19. High-throughput proteomics : optical approaches.

    SciTech Connect (OSTI)

    Davidson, George S.

    2008-09-01T23:59:59.000Z

    Realistic cell models could greatly accelerate our ability to engineer biochemical pathways and the production of valuable organic products, which would be of great use in the development of biofuels, pharmaceuticals, and the crops for the next green revolution. However, this level of engineering will require a great deal more knowledge about the mechanisms of life than is currently available. In particular, we need to understand the interactome (which proteins interact) as it is situated in the three dimensional geometry of the cell (i.e., a situated interactome), and the regulation/dynamics of these interactions. Methods for optical proteomics have become available that allow the monitoring and even disruption/control of interacting proteins in living cells. Here, a range of these methods is reviewed with respect to their role in elucidating the interactome and the relevant spatial localizations. Development of these technologies and their integration into the core competencies of research organizations can position whole institutions and teams of researchers to lead in both the fundamental science and the engineering applications of cellular biology. That leadership could be particularly important with respect to problems of national urgency centered around security, biofuels, and healthcare.

  20. High Throughput Materials Characterization John M. Gregoire

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) EnvironmentalGyroSolé(tm) Harmonicbet WhenHiggs BosonAccurate knowledge of

  1. On Achieving Optimal Throughput with Network Coding

    E-Print Network [OSTI]

    Li, Baochun

    to the problem of optimizing end-to- end throughput in undirected data networks. We first illustrate the powerOn Achieving Optimal Throughput with Network Coding Zongpeng Li, Baochun Li, Dan Jiang, Lap Chi Lau Abstract-- With the constraints of network topologies and link capacities, achieving the optimal end

  2. Final Project Report: Tools for the Development of High Performance Energy Applications and Systems

    SciTech Connect (OSTI)

    Hollingsworth, Jeff

    2014-10-22T23:59:59.000Z

    This project concentrated on various aspects of creating tool infrastructure to make it easier to program large-scale parallel computers. The research conducted during this project is summarized in this report. The complete details of the work are available in the ten publications listed at the end of the report. Many of the concepts created during this project have been incorporated into tools and made available as freely downloadable software (at www.dyninst.org). It also supported the Ph.D. studies of three students.

  3. DESIGN AND CHARACTERIZATION OF A NOVEL ICP PLASMA TOOL FOR HIGH SPEED AND HIGH ACCURACY DRIE PROCESSING

    E-Print Network [OSTI]

    Technische Universiteit Delft

    the ion density profile across the plasma chamber in a research DRIE tool. The plasma conditions are: Ar ion density. Process chamber centre EdgeEdge 0 100 200 300 400 Sheetthickness(m) Process chamber argon ion density measured in a conventional ICP. 0 0.2 0.4 0.6 0.8 1 Process chamber centre Edge

  4. Active wear and failure mechanisms of TiN-coated high speed steel and TiN-coated cemented carbide tools when machining powder metallurgically made stainless steels

    SciTech Connect (OSTI)

    Jiang, L.; Haenninen, H.; Paro, J.; Kauppinen, V. [Helsinki Univ. of Technology, Espoo (Finland)

    1996-09-01T23:59:59.000Z

    In this study, active wear and failure mechanisms of both TiN-coated high speed steel and TiN-coated cemented carbide tools when machining stainless steels made by powder metallurgy in low and high cutting speed ranges, respectively, have been investigated. Abrasive wear mechanisms, fatigue-induced failure, and adhesive and diffusion wear mechanisms mainly affected the tool life of TiN-coated high speed steel tools at cutting speeds below 35 m/min, between 35 and 45 m/min, and over 45 m/min, respectively. Additionally, fatigue-induced failure was active at cutting speeds over 45 m/min in the low cutting speed range when machining powder metallurgically made duplex stainless steel 2205 and austenitic stainless steel 316L. In the high cutting speed range, from 100 to 250 m/min, fatigue-induced failure together with diffusion wear mechanism, affected the tool life of TiN-coated cemented carbide tools when machining both 316L and 2205 stainless steels. It was noticed that the tool life of TiN-coated high speed steel tools used in the low cutting speed range when machining 2205 steel was longer than that when machining 316L steel, whereas the tool life of TiN-coated cemented carbide tools used in the high cutting speed range when machining 316L steel was longer than that when machining 2205 steel.

  5. Cantilever Sensors: Nanomechanical Tools for Diagnostics

    E-Print Network [OSTI]

    Datar, Ram

    Cantilever sensors have attracted considerable attention over the last decade because of their potential as a highly sensitive sensor platform for high throughput and multiplexed detection of proteins and nucleic acids. A ...

  6. Conformance Tool High Level Design Document: IEC 61850 Cyber Security Acceleration Project

    SciTech Connect (OSTI)

    Edgar, Thomas W.

    2013-05-01T23:59:59.000Z

    This document is the high level design document for the Pacific Northwest National Laboratory (PNNL) IEC 62351-3, 4 and 6 standards conformance test software toolkit.

  7. Stable Throughput in a Cognitive Wireless Network

    E-Print Network [OSTI]

    Fanous, Anthony

    2012-01-01T23:59:59.000Z

    We study, from a network layer perspective, the effect of an Ad-Hoc secondary network with N nodes randomly accessing the spectrum licensed to a primary node during the idle slots of the primary user. If the sensing is perfect, then the secondary nodes do not interfere with the primary node and hence do not affect its stable throughput. In case of imperfect sensing, it is shown that if the primary user's arrival rate is less than some calculated finite value, cognitive nodes can employ any transmission power or probabilities without affecting the primary user's stability; otherwise, the secondary nodes should control their transmission parameters to reduce the interference on the primary. It is also shown that in contrast with the primary's maximum stable throughput which strictly decreases with increased sensing errors, the throughput of the secondary nodes might increase with sensing errors as more transmission opportunities become available to them. Finally, we explore the use of the secondary nodes as rel...

  8. Development of a High-Temperature Diagnostics-While-Drilling Tool

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the YouTube| DepartmentStatementDepartment ofVisitsDeterminationsProgramHigh-Tonnage |SANDIA

  9. Throughput Analysis of Wireless Ad-Hoc Cognitive Radio Networks 

    E-Print Network [OSTI]

    Banaei, Armin

    2014-04-25T23:59:59.000Z

    In this dissertation we consider the throughput performance of cognitive radio networks and derive the optimal sensing and access schemes for secondary users that maximizes their sum-throughput while guaranteeing certain ...

  10. Maximum Throughput Power Control in CDMA Wireless Networks

    E-Print Network [OSTI]

    Mellor-Crummey, John

    Maximum Throughput Power Control in CDMA Wireless Networks Anastasios Giannoulis Department introduce cross­layer, distributed power control algorithms that guarantee maximum possible data throughput performing dynamic routing and scheduling together with power control. The cross­layer interaction consists

  11. An overlay architecture for throughput optimal multipath routing

    E-Print Network [OSTI]

    Jones, Nathaniel M.

    Legacy networks are often designed to operate with simple single-path routing, like shortest-path, which is known to be throughput suboptimal. On the other hand, previously proposed throughput optimal policies (i.e., ...

  12. Throughput Analysis of Wireless Ad-Hoc Cognitive Radio Networks

    E-Print Network [OSTI]

    Banaei, Armin

    2014-04-25T23:59:59.000Z

    In this dissertation we consider the throughput performance of cognitive radio networks and derive the optimal sensing and access schemes for secondary users that maximizes their sum-throughput while guaranteeing certain quality of service...

  13. High-resolution microcalorimeter detectors as a tool in the future of nuclear safeguards

    SciTech Connect (OSTI)

    Hoteling, Nathan J [Los Alamos National Laboratory; Hoover, Andrew S [Los Alamos National Laboratory

    2010-01-01T23:59:59.000Z

    New measurements are presented from the LANL-NIST microcalorimeter array for two standard plutonium sources. The results demonstrate substantially smaller error bars obtained from the spectral analysis program FRAM. Some areas of improvement to the analysis technique have been identified, indicating that the micro calorimeter results can be improved upon. These results support the viability of a device for performing real nuclear safeguards measurements in the near future. The challenge of providing reliably accurate and precise data is a critical component of any safeguards initiative. In the realm of nuclear safeguards, this is an especially daunting task since inaccurate and/or imprecise data could have very serious international consequences. As such, there is a constant drive within the community to establish better measurement and analysis techniques in order to further reduce the associated errors and uncertainties. Even with todays state of the art equipment, measurement uncertainties can extend to several significant quantities worth of material over a relatively modest period of time. Furthermore, there is a strong desire for improved nondestructive analysis techniques in order to reduce both the cost, turnover rate, and inconvenience of destructive analyses. One promising new technology that may help to realize these goals is that of gamma-ray microcalorimeter detectors. The hallmark quality of this new technique is the ability to achieve energy resolution nearly an order of magnitude better than typical planar high-purity germanium (HPGe) detectors. Such an improvement may help reduce uncertainties associated with, for instance, plutonium isotopics or uranium enrichment measurements. This may, in turn, help to reduce uncertainties in total plutonium and/or uranium content in a given sample without the need for destructive analysis. In this paper, we will describe this new detector technology as well as some recent measurements carried out with the LANL-NIST gamma-ray microcalorimeter ({micro}cal) array. Discussion will focus on the capabilities of this technology as well as the progress toward a practical measurement device.

  14. PROCESS CHANGES TO DWPF TO INCREASE THROUGHPUT AND INCORPORATE SALT STREAMS

    SciTech Connect (OSTI)

    Herman, C; David Peeler, D; Tommy Edwards, T; Michael Stone, M; Michael02 Smith, M

    2007-06-13T23:59:59.000Z

    The Defense Waste Processing Facility (DWPF) has been vitrifying High Level Waste sludge since 1996. Sludge batch 1a, 1b, 2, and 3 have been successfully stabilized. In the last several years, the Savannah River National Laboratory (SRNL) has worked with DWPF to implement process and compositional changes to improve throughput. These changes allowed significant increases in waste throughput for processing of sludge batch 3 and will be necessary to maintain reasonable throughput for Sludge Batch 4 (SB4). SB4 processing was initiated in June 2007 and will be the first significantly HM-type sludge batch processed. This sludge is high in aluminum and other components troublesome to DWPF processing. In addition, coupled processing is scheduled to start in the next fiscal year, which will also impact throughput. Coupled processing will begin with the incorporation of waste streams from the Actinide Removal Process and the Modular Caustic Side Solvent Extraction Unit and will eventually transition to the feed from the larger scale Salt Waste Processing Facility. A discussion of the programs to improve throughput and implement salt processing will be provided.

  15. New hydrocracking catalysts increase throughput, run length

    SciTech Connect (OSTI)

    Huizinga, T. [Shell Internationale Petroleum Mij., The Hague (Netherlands); Theunissen, J.M.H. [Rayong Refinery Co. Ltd., Rayong (Thailand); Minderhoud, H.; Veen, R. van [Koninklijke/Shell-Lab., Amsterdam (Netherlands)

    1995-06-26T23:59:59.000Z

    An improved, second-stage hydrocracking catalyst has been developed by combining stabilized Y zeolites with amorphous silica alumina cracking components. A commercial application of this catalyst, along with a new, first-stage zeolitic hydrocracking catalyst, resulted in increased unit throughput and cycle length. The paper discusses the hydrocracking process, first-stage catalysts, second-stage catalysts, hydrogenation process, commercial results, and product properties.

  16. Trapped Capacity: Scheduling under a Power Cap to Maximize Machine-Room Throughput

    E-Print Network [OSTI]

    Pakin, Scott

    in the machine room and thereby increase system throughput. Our goal is not to reduce energy or power consumption power and energy in machine rooms. In practice the power for machine rooms is well over-provisioned, specified by high energy LINPACK runs or nameplate power estimates. This results in a considerable amount

  17. Veeco Develops Tools to Drive Down HBLED Costs

    Broader source: Energy.gov [DOE]

    Veeco is working in partnership with Sandia National Laboratories and Philips Lumileds to drive down the cost of high-brightness LEDs by implementing process simulation tools and by improving temperature measurement and control methods to increase MOCVD yield. Veeco is working with Sandia to reduce the cost of ownership (COO) of the deposition equipment by, for example, using a heated flow flange, which reduces the consumption of the expensive precursors (ammonia, nitrogen, hydrogen, and the metal organics) by 40 percent. Two different types of pyrometers developed by Sandia and Veeco are being tested by Philips Lumileds to control the substrate temperature, which helps determine the color of the LED. If all works according to plan, the COO will be reduced by at least 75 percent by improving throughput, growth uniformity, yield, and temperature stabilization.

  18. Method and apparatus for maximizing throughput of indirectly heated rotary kilns

    DOE Patents [OSTI]

    Coates, Ralph L; Smoot, L. Douglas; Hatfield, Kent E

    2012-10-30T23:59:59.000Z

    An apparatus and method for achieving improved throughput capacity of indirectly heated rotary kilns used to produce pyrolysis products such as shale oils or coal oils that are susceptible to decomposition by high kiln wall temperatures is disclosed. High throughput is achieved by firing the kiln such that optimum wall temperatures are maintained beginning at the point where the materials enter the heating section of the kiln and extending to the point where the materials leave the heated section. Multiple high velocity burners are arranged such that combustion products directly impact on the area of the kiln wall covered internally by the solid material being heated. Firing rates for the burners are controlled to maintain optimum wall temperatures.

  19. Percussion tool

    DOE Patents [OSTI]

    Reed, Teddy R.

    2006-11-28T23:59:59.000Z

    A percussion tool is described and which includes a housing mounting a tool bit; a reciprocally moveable hammer borne by the housing and which is operable to repeatedly strike the tool bit; and a reciprocally moveable piston enclosed within the hammer and which imparts reciprocal movement to the reciprocally moveable hammer.

  20. Streak Seeding Automation Using Silicon Tools CUCS-015-06

    E-Print Network [OSTI]

    Georgiev, Atanas

    diseases. Despite the recent impressive achievements in the high-throughput (HTP) protein crystallography solution by the modern HTP software. In pilot studies of Phase 1 of the Protein Structure Initiative (PSI

  1. Simrank: Rapid and sensitive general-purpose k-mer search tool

    SciTech Connect (OSTI)

    DeSantis, T.Z.; Keller, K.; Karaoz, U.; Alekseyenko, A.V; Singh, N.N.S.; Brodie, E.L; Pei, Z.; Andersen, G.L; Larsen, N.

    2011-04-01T23:59:59.000Z

    Terabyte-scale collections of string-encoded data are expected from consortia efforts such as the Human Microbiome Project (http://nihroadmap.nih.gov/hmp). Intra- and inter-project data similarity searches are enabled by rapid k-mer matching strategies. Software applications for sequence database partitioning, guide tree estimation, molecular classification and alignment acceleration have benefited from embedded k-mer searches as sub-routines. However, a rapid, general-purpose, open-source, flexible, stand-alone k-mer tool has not been available. Here we present a stand-alone utility, Simrank, which allows users to rapidly identify database strings the most similar to query strings. Performance testing of Simrank and related tools against DNA, RNA, protein and human-languages found Simrank 10X to 928X faster depending on the dataset. Simrank provides molecular ecologists with a high-throughput, open source choice for comparing large sequence sets to find similarity.

  2. Technology support for initiation of high-throughput processing of thin-film CdTe PV modules. Phase 3 final technical report, 14 March 1997--1 April 1998

    SciTech Connect (OSTI)

    Powell, R.C.; Dorer, G.L.; Jayamaha, U.; Hanak, J.J. [Solar Cells, Inc., Toledo, OH (United States)

    1998-09-01T23:59:59.000Z

    Thin-film PV devices based on cadmium telluride have been identified as one of the candidates for high-performance, low-cost source of renewable electrical energy. Roadblocks to their becoming a part of the booming PV market growth have been a low rate of production and high manufacturing cost caused by several rate-limiting process steps. Solar Cells Inc. has focused on the development of manufacturing processes that will lead to high volume and low-cost manufacturing of solar cells and on increasing the performance of the present product. The process research in Phase 3 was concentrated on further refinement of a newly developed vapor transport deposition (VTD) process and its implementation into the manufacturing line. This development included subsystems for glass substrate transport, continuous feed of source materials, generation of source vapors, and uniform deposition of the semiconductor layers. As a result of this R and D effort, the VTD process has now achieved a status in which linear coating speeds in excess of 8 ft/min have been achieved for the semiconductor, equal to about two modules per minute, or 144 kW per 24 hour day. The process has been implemented in a production line, which is capable of round-the-clock continuous production of coated substrates 120 cm x 60 cm in size at a rate of 1 module every four minutes, equal to 18 kW/day. Currently the system cycle time is limited by the rate of glass introduction into the system and glass heating, but not by the rate of the semiconductor deposition. A new SCI record efficiency of 14.1% has been achieved for the cells.

  3. Tests using the Globus "gsiftp" tool between Caltech and Argonne

    E-Print Network [OSTI]

    DRAFT Tests using the Globus "gsiftp" tool between Caltech and Argonne Julian Bunn, 16th December 1999 Introduction Measurements of throughput on the WAN from Caltech/CACR to Argonne/MCS were made/null on the Argonne machine. The CACR machine used was the 256-CPU Exemplar X- class "neptune

  4. Techniques and tools for measuring energy efficiency of scientific software applications

    E-Print Network [OSTI]

    Abdurachmanov, David; Eulisse, Giulio; Knight, Robert; Niemi, Tapio; Nurminen, Jukka K; Nyback, Filip; Pestana, Goncalo; Ou, Zhonghong; Khan, Kashif

    2014-01-01T23:59:59.000Z

    The scale of scientific High Performance Computing (HPC) and High Throughput Computing (HTC) has increased significantly in recent years, and is becoming sensitive to total energy use and cost. Energy-efficiency has thus become an important concern in scientific fields such as High Energy Physics (HEP). There has been a growing interest in utilizing alternate architectures, such as low power ARM processors, to replace traditional Intel x86 architectures. Nevertheless, even though such solutions have been successfully used in mobile applications with low I/O and memory demands, it is unclear if they are suitable and more energy-efficient in the scientific computing environment. Furthermore, there is a lack of tools and experience to derive and compare power consumption between the architectures for various workloads, and eventually to support software optimizations for energy efficiency. To that end, we have performed several physical and software-based measurements of workloads from HEP applications running o...

  5. Throughput-cost analysis of optical flow switching

    E-Print Network [OSTI]

    Chan, Vincent W. S.

    In this paper, we employ a cost model embodying major sources of capital expenditure (CapEx) to compare the throughput-cost tradeoff offered by optical flow switching to that of more traditional optical network architectures.

  6. Maximizing the throughput of large ad hoc wireless networks

    E-Print Network [OSTI]

    Hua, Y; Huang, Y; Garcia-Luna-Aceves, J J

    2006-01-01T23:59:59.000Z

    multi-input, single-output (MISO) protocol. During eachthe maximum throughput of the MISO protocol, in bits-meters/s/ Hz/node, is C MISO = (n ? 1) A log 2 1 + 2n P T ? h

  7. Using Channel Output Feedback to Increase Throughput in Hybrid-ARQ

    E-Print Network [OSTI]

    Agrawal, Mayur; Love, David J; Balakrishnan, Venkataramanan

    2011-01-01T23:59:59.000Z

    Since its inclusion in the High Speed Downlink Packet Access (HSPDA) standard, the hybrid-ARQ protocol has become very popular in packet transmission schemes. Hybrid-ARQ combines the normal automatic repeat request (ARQ) method with error correction codes to increase reliability and throughput. The use of rate-compatible punctured turbo codes has been shown to work well for block fading channels. In this paper, we look at improving upon this performance using feedback information from the receiver; in particular, using a turbo code in conjunction with a proposed linear feedback code for the Rayleigh fading channels. The new hybrid-ARQ scheme is extended to various different multiple-antenna scenarios (MIMO/MISO/SISO) with varying amounts of feedback information. Simulations are given to illustrate gains in throughput.

  8. Multiscale Toxicology- Building the Next Generation Tools for Toxicology

    SciTech Connect (OSTI)

    Retterer, S. T. [ORNL] [ORNL; Holsapple, M. P. [Battelle Memorial Institute] [Battelle Memorial Institute

    2013-10-31T23:59:59.000Z

    A Cooperative Research and Development Agreement (CRADA) was established between Battelle Memorial Institute (BMI), Pacific Northwest National Laboratory (PNNL), Oak Ridge National Laboratory (ORNL), Brookhaven National Laboratory (BNL), Lawrence Livermore National Laboratory (LLNL) with the goal of combining the analytical and synthetic strengths of the National Laboratories with BMI?s expertise in basic and translational medical research to develop a collaborative pipeline and suite of high throughput and imaging technologies that could be used to provide a more comprehensive understanding of material and drug toxicology in humans. The Multi-Scale Toxicity Initiative (MSTI), consisting of the team members above, was established to coordinate cellular scale, high-throughput in vitro testing, computational modeling and whole animal in vivo toxicology studies between MSTI team members. Development of a common, well-characterized set of materials for testing was identified as a crucial need for the initiative. Two research tracks were established by BMI during the course of the CRADA. The first research track focused on the development of tools and techniques for understanding the toxicity of nanomaterials, specifically inorganic nanoparticles (NPs). ORNL?s work focused primarily on the synthesis, functionalization and characterization of a common set of NPs for dissemination to the participating laboratories. These particles were synthesized to retain the same surface characteristics and size, but to allow visualization using the variety of imaging technologies present across the team. Characterization included the quantitative analysis of physical and chemical properties of the materials as well as the preliminary assessment of NP toxicity using commercially available toxicity screens and emerging optical imaging strategies. Additional efforts examined the development of high-throughput microfluidic and imaging assays for measuring NP uptake, localization, and toxicity in vitro. The second research track within the MSTI CRADA focused on the development of ex vivo animal models for examining druginduced cardiotoxicity. ORNL's role in the second track was limited initially, but was later expanded to include the development of microfluidic platforms that might facilitate the translation of Cardiac 'Microwire' technologies developed at the University of Toronto into a functional platform for drug screening and predictive assessment of cardiotoxicity via highthroughput measurements of contractility. This work was coordinated by BMI with the Centre for the Commercialization of Regenerative Medicine (CCRM) and the University of Toronto (U Toronto). This partnership was expanded and culminated in the submission of proposal to Work for Others (WFO) agencies to explore the development of a broader set of microphysiological systems, a so call human-on-a-chip, that could be used for toxicity screening and the evaluation of bio-threat countermeasures.

  9. Design Concept Evaluation Using System Throughput Model

    SciTech Connect (OSTI)

    G. Sequeira; W. M. Nutt Ph.D

    2004-05-28T23:59:59.000Z

    The U.S. Department of Energy (DOE) Office of Civilian Radioactive Waste Management (OCRWM) is currently developing the technical bases to support the submittal of a license application for construction of a geologic repository at Yucca Mountain, Nevada to the U.S. Nuclear Regulatory Commission. The Office of Repository Development (ORD) is responsible for developing the design of the proposed repository surface facilities for the handling of spent nuclear fuel and high level nuclear waste. Preliminary design activities are underway to sufficiently develop the repository surface facilities design for inclusion in the license application. The design continues to evolve to meet mission needs and to satisfy both regulatory and program requirements. A system engineering approach is being used in the design process since the proposed repository facilities are dynamically linked by a series of sub-systems and complex operations. In addition, the proposed repository facility is a major system element of the overall waste management process being developed by the OCRWM. Such an approach includes iterative probabilistic dynamic simulation as an integral part of the design evolution process. A dynamic simulation tool helps to determine if: (1) the mission and design requirements are complete, robust, and well integrated; (2) the design solutions under development meet the design requirements and mission goals; (3) opportunities exist where the system can be improved and/or optimized; and (4) proposed changes to the mission, and design requirements have a positive or negative impact on overall system performance and if design changes may be necessary to satisfy these changes. This paper will discuss the type of simulation employed to model the waste handling operations. It will then discuss the process being used to develop the Yucca Mountain surface facilities model. The latest simulation model and the results of the simulation and how the data were used in the design evolution process will also be discussed. Since the use of dynamic simulation is iterative and integral to the design effort, future activities will also be summarized. The paper will close discussing lessons learned from applying dynamic simulation to designing complex systems, and will discuss what pitfalls to avoid and recommendations for developing flexibility in system model development.

  10. Development and application of management tools within a high-mix, low-volume lean aerospace manufacturing environment

    E-Print Network [OSTI]

    McKenney, Kevin (Kevin Bryan), 1977-

    2005-01-01T23:59:59.000Z

    The design and implementation of a lean production system is a complex task requiring an intimate understanding of the fundamental lean principles. Much of the published lean literature is written at a high level of ...

  11. High-throughput comparison of gene fitness among related bacteria

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    licenses/by/2.0), which permits unrestricted use,Mutations in this gene permit second site mutations in hnsIt is known that rpoS mutants permit mutations in hns in

  12. Microchip Technology for High-Throughput Cancer Pathology

    E-Print Network [OSTI]

    Duberow, Jr, David Paul

    2009-01-01T23:59:59.000Z

    was designed using riboflavin as the photoinitiator. Allwith 6 ”L of 0.1% (w/v) riboflavin (Sigma) and 1.25 ”L 100%

  13. High-throughput liquid-absorption preconcentrator sampling methods

    DOE Patents [OSTI]

    Zaromb, Solomon (95706 William Dr., Hinsdale, IL 60521)

    1994-01-01T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis.

  14. High throughput analysis of samples in flowing liquid

    DOE Patents [OSTI]

    Ambrose, W. Patrick (Los Alamos, NM); Grace, W. Kevin (Los Alamos, NM); Goodwin, Peter M. (Los Alamos, NM); Jett, James H. (Los Alamos, NM); Orden, Alan Van (Fort Collins, CO); Keller, Richard A. (White Rock, NM)

    2001-01-01T23:59:59.000Z

    Apparatus and method enable imaging multiple fluorescent sample particles in a single flow channel. A flow channel defines a flow direction for samples in a flow stream and has a viewing plane perpendicular to the flow direction. A laser beam is formed as a ribbon having a width effective to cover the viewing plane. Imaging optics are arranged to view the viewing plane to form an image of the fluorescent sample particles in the flow stream, and a camera records the image formed by the imaging optics.

  15. Potential of High-Throughput Experimentation with Ammonia Borane...

    Broader source: Energy.gov (indexed) [DOE]

    and theory - Materials Discovery DOE BES Hydrogen Fuel Initiative * Structure and dynamics (Neutron and NMR) - Experimental and computational studies of di- hydrogen bonding...

  16. Integrated microbioreactor arrays for high-throughput experimentation

    E-Print Network [OSTI]

    Lee, Harry, 1976-

    2006-01-01T23:59:59.000Z

    Bioprocesses with microbial cells play an important role in producing biopharmaceuticals such as human insulin and human growth hormone, and other products such as amino acids and biopolymers. Because bioprocesses involve ...

  17. High-throughput Synthesis and Metrology of Graphene Materials

    E-Print Network [OSTI]

    Ghazinejad, Maziar Ghazinejad

    2012-01-01T23:59:59.000Z

    and large-area graphene plane as a floor. Preparation ofgraphene was dried and prepared for dye coating. Dye Preparation and

  18. Constant pressure high throughput membrane permeation testing system

    DOE Patents [OSTI]

    Albenze, Erik J.; Hopkinson, David P.; Luebke, David R.

    2014-09-02T23:59:59.000Z

    The disclosure relates to a membrane testing system for individual evaluation of a plurality of planar membranes subjected to a feed gas on one side and a sweep gas on a second side. The membrane testing system provides a pressurized flow of a feed and sweep gas to each membrane testing cell in a plurality of membrane testing cells while a stream of retentate gas from each membrane testing cell is ported by a retentate multiport valve for sampling or venting, and a stream of permeate gas from each membrane testing cell is ported by a permeate multiport valve for sampling or venting. Back pressure regulators and mass flow controllers act to maintain substantially equivalent gas pressures and flow rates on each side of the planar membrane throughout a sampling cycle. A digital controller may be utilized to position the retentate and permeate multiport valves cyclically, allowing for gas sampling of different membrane cells over an extended period of time.

  19. High mass throughput particle generation using multiple nozzle spraying

    DOE Patents [OSTI]

    Pui, David Y. H. (Plymouth, MN); Chen, Da-Ren (Creve Coeur, MO)

    2009-03-03T23:59:59.000Z

    Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.

  20. Technology Offer High-throughput Algorithm for Automated

    E-Print Network [OSTI]

    reliability enables the same LC-MS analyses with less human resources as manual correction is not necessary Chemical industry: identification and quantitation of chemical composition of various analytes, e.g. oils

  1. Optical Multiplexing for High-Throughput Spectroscopic Analysis. 

    E-Print Network [OSTI]

    Ahmed, Saadiah

    2012-05-03T23:59:59.000Z

    Implantable optical biosensors are being developed as aids for medical monitoring. Such optical biosensors are analyzed for performance in dynamic sensor testing environment. Multi-Frequency Phase Fluorometer (MFPF) is a key measuring device...

  2. Statistical Algorithms for High-throughput Biological Data /

    E-Print Network [OSTI]

    Jeong, Kyowon

    2013-01-01T23:59:59.000Z

    Nat Genet, Jun 2012. [LHW + 09] Heng Li, Bob Handsaker, Alec25(16):2078–2079, [Li11] Heng Li. Tabix: fast retrieval ofYang, Chun-Qing Song, Le-Heng Wang, Chao Liu, Yan Fu, Zuo-

  3. An apparatus for high throughput muscle cell experimentation

    E-Print Network [OSTI]

    Garcia-Webb, Michael G. (Michael Gregory)

    2006-01-01T23:59:59.000Z

    The cardiac ventricular muscle cell (myocyte) is a key experimental system for exploring the mechanical properties of the diseased and healthy heart. The myocyte experimental model provides a higher level of physiological ...

  4. Towards Experimental Annotation of Genes by High Throughput Sequencing

    SciTech Connect (OSTI)

    Bradbury, Andrew [Los Alamos National Laboratory

    2010-06-03T23:59:59.000Z

    Andrew Bradbury of Los Alamos National Laboratory discusses turning annotation into a sequencing pipeline on June 3, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM

  5. High-throughput liquid-absorption preconcentrator sampling methods

    DOE Patents [OSTI]

    Zaromb, S.

    1994-07-12T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis. 12 figs.

  6. Operational streamlining in a high-throughput genome sequencing center

    E-Print Network [OSTI]

    Person, Kerry P. (Kerry Patrick)

    2006-01-01T23:59:59.000Z

    Advances in medicine rely on accurate data that is rapidly provided. It is therefore critical for the Genome Sequencing platform of the Broad Institute of MIT and Harvard to continually strive to reduce cost, improve ...

  7. Methods and devices for high-throughput dielectrophoretic concentration

    DOE Patents [OSTI]

    Simmons, Blake A. (San Francisco, CA); Cummings, Eric B. (Livermore, CA); Fiechtner, Gregory J. (Germantown, MD); Fintschenko, Yolanda (Livermore, CA); McGraw, Gregory J. (Ann Arbor, MI); Salmi, Allen (Escalon, CA)

    2010-02-23T23:59:59.000Z

    Disclosed herein are methods and devices for assaying and concentrating analytes in a fluid sample using dielectrophoresis. As disclosed, the methods and devices utilize substrates having a plurality of pores through which analytes can be selectively prevented from passing, or inhibited, on application of an appropriate electric field waveform. The pores of the substrate produce nonuniform electric field having local extrema located near the pores. These nonuniform fields drive dielectrophoresis, which produces the inhibition. Arrangements of electrodes and porous substrates support continuous, bulk, multi-dimensional, and staged selective concentration.

  8. Targeted Tandem Mass Spectrometry for High-Throughput Comparative...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    states. Herein, we report on a targeted LC-MSMS capability realized with a 7 Tesla Fourier transform ion cyclotron resonance (FTICR) mass spectrometer equipped with a...

  9. High Throughput Combinatorial Screening of Biometic Metal-Organic...

    Broader source: Energy.gov (indexed) [DOE]

    - 50 cm -1 ) red-shifts upon adsorption *Can be complex, depending on exact adsorption environment *Partial charge transfer weakens H-H bond, red-shift *Are such strong...

  10. High-Throughput Transfer Imprinting for Organic Semiconductors

    E-Print Network [OSTI]

    Choo, Gihoon

    2013-08-06T23:59:59.000Z

    semiconductors because heat and pressure used in thermal nanoimprint do not damage functional materials. However, issues such as residual layer removal and mold contamination still limit the application of nanoimprint for organic semiconductor patterning...

  11. Microchip Technology for High-Throughput Cancer Pathology

    E-Print Network [OSTI]

    Duberow, Jr, David Paul

    2009-01-01T23:59:59.000Z

    S. , and Marra, M. Resuspension of DNA Sequencing Reactionstability. (A) Sample resuspension in low-concentrationand used as the sole resuspension buffer following sample

  12. High-throughput methods for characterizing the immune repertoire

    E-Print Network [OSTI]

    Laserson, Uri

    2013-01-01T23:59:59.000Z

    The adaptive immune system is one of the primary mediators in almost every major human disease, including infections, cancer, autoimmunity, and inflammation-based disorders. It fundamentally functions as a molecular ...

  13. High-throughput Synthesis and Metrology of Graphene Materials

    E-Print Network [OSTI]

    Ghazinejad, Maziar Ghazinejad

    2012-01-01T23:59:59.000Z

    24 2.5 Demonstration of PGN based Supercapacitor2-11 (a) CV curves of supercapacitor based on as-grown PGNFigure 2-12 CV curves of supercapacitor based on HNO3 acid

  14. High-Throughput Transfer Imprinting for Organic Semiconductors 

    E-Print Network [OSTI]

    Choo, Gihoon

    2013-08-06T23:59:59.000Z

    . In this work, nanoimprint-based transfer imprinting of organic semiconductor is studied. In the same time the suggested technique is simulated with COMSOL multi-physics simulator to understand its mechanism. This transfer printing technique utilize thermal...

  15. Algorithms for Next-Generation High-Throughput Sequencing Technologies

    E-Print Network [OSTI]

    Kao, Wei-Chun

    2011-01-01T23:59:59.000Z

    parameters for 4 different tiles of the 76- cycle PhiX174scores at error tolerance . . . . 2.9 Tile-specific errorsection). Normalizing by the tile-wide average c t is to

  16. High-Throughput Characterization of Porous Materials Using Graphics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOnItem NotEnergy,ARMFormsGasReleaseSpeechesHallNot Logged3

  17. High-Throughput Dry Processes for Large-Area Devices

    SciTech Connect (OSTI)

    BUSS,RICHARD J.; HEBNER,GREGORY A.; RUBY,DOUGLAS S.; YANG,PIN

    1999-11-01T23:59:59.000Z

    In October 1996, an interdisciplinary team began a three-year LDRD project to study the plasma processes of reactive ion etching and plasma-enhanced chemical vapor deposition on large-area silicon devices. The goal was to develop numerical models that could be used in a variety of applications for surface cleaning, selective etching, and thin-film deposition. Silicon solar cells were chosen as the experimental vehicle for this project because an innovative device design was identified that would benefit from immediate performance improvement using a combination of plasma etching and deposition processes. This report presents a summary of the technical accomplishments and conclusions of the team.

  18. METHODS AND APPLICATIONS High-throughput instant quantification of

    E-Print Network [OSTI]

    Ihee, Hyotcherl

    based on photoactive yellow protein turn off/on label Youngmin Kim,1,2 Prabhakar Ganesan,1 on the Photoactive yellow protein turn Off/On Label (POOL) system that can instantly quan- tify the concentration Gel Electrophoresis; POOL, PYP turn Off/On Label; PYP, Photoactive Yellow Protein; SUMO, Small

  19. High Throughput Analysis of Breast Cancer Specimens on the Grid

    E-Print Network [OSTI]

    cancer accounts for about 30% of all cancers and 15% of all cancer deaths in women in the United States in the United States. Women living in North America have the highest rate of breast cancer in the world [1]. In spite of the increase in the incidence of the disease, the death rates of breast cancer continue

  20. NETL Studies High Throughput Membrane Screening | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Saleshttp://www.fnal.gov/directorate/nalcal/nalcal02_07_05_files/nalcal.gif Directorate1, Issue 23 NETL Scientist Wins 2011NETLNETL

  1. Potential of High-Throughput Experimentation with Ammonia Borane Solid

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOrigin of Contamination in235-1Department of60 DATE:AnnualDepartment ofPotentialYield

  2. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 toAdvances WindRobust,

  3. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 toAdvances WindRobust,Robust,

  4. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What's PossibleRadiation Protection TechnicalResonantNovember 15 toAdvances WindRobust,Robust,Robust,

  5. High Throughput Combinatorial Screening of Biometic Metal-Organic Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a r r t t m m e efor Military

  6. High Throughput/Combinatorial Screening of Hydrogen Storage Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a r r t t m m e efor

  7. High Throughput/Combinatorial Screening of Hydrogen Storage Materials: UOP

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a r r t t m m e eforApproaches |

  8. High-Throughput and Combinatorial Screening of Hydrogen Storage Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a rDepartment ofofa

  9. Queer Tools

    E-Print Network [OSTI]

    Hacker, Randi; Tsutsui, William

    2007-11-19T23:59:59.000Z

    Broadcast Transcript: Chindogu. Did someone say "Bless you?" No need. This is a Japanese word that means "queer tools" and it was coined to describe the Japanese penchant for unusual inventions. From toilet paper rolls that attach to the head...

  10. Workflow Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    at NERSC go here. Galaxy - Galaxy is a web based workflow tool that is use by the genomics community. It allows you to define job dependencies via a web based workflow engine....

  11. Tools | JCESR

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tools JCESR Logos Logos are available for download in jpg format. To view the full-size logo file, click the description under the version of the logo you are interested in. When...

  12. Techniques and tools for measuring energy efficiency of scientific software applications

    E-Print Network [OSTI]

    David Abdurachmanov; Peter Elmer; Giulio Eulisse; Robert Knight; Tapio Niemi; Jukka K. Nurminen; Filip Nyback; Goncalo Pestana; Zhonghong Ou; Kashif Khan

    2014-10-10T23:59:59.000Z

    The scale of scientific High Performance Computing (HPC) and High Throughput Computing (HTC) has increased significantly in recent years, and is becoming sensitive to total energy use and cost. Energy-efficiency has thus become an important concern in scientific fields such as High Energy Physics (HEP). There has been a growing interest in utilizing alternate architectures, such as low power ARM processors, to replace traditional Intel x86 architectures. Nevertheless, even though such solutions have been successfully used in mobile applications with low I/O and memory demands, it is unclear if they are suitable and more energy-efficient in the scientific computing environment. Furthermore, there is a lack of tools and experience to derive and compare power consumption between the architectures for various workloads, and eventually to support software optimizations for energy efficiency. To that end, we have performed several physical and software-based measurements of workloads from HEP applications running on ARM and Intel architectures, and compare their power consumption and performance. We leverage several profiling tools (both in hardware and software) to extract different characteristics of the power use. We report the results of these measurements and the experience gained in developing a set of measurement techniques and profiling tools to accurately assess the power consumption for scientific workloads.

  13. Toward a Performance/Resilience Tool for Hardware/Software Co-Design of High-Performance Computing Systems

    SciTech Connect (OSTI)

    Engelmann, Christian [ORNL] [ORNL; Naughton, III, Thomas J [ORNL

    2013-01-01T23:59:59.000Z

    xSim is a simulation-based performance investigation toolkit that permits running high-performance computing (HPC) applications in a controlled environment with millions of concurrent execution threads, while observing application performance in a simulated extreme-scale system for hardware/software co-design. The presented work details newly developed features for xSim that permit the injection of MPI process failures, the propagation/detection/notification of such failures within the simulation, and their handling using application-level checkpoint/restart. These new capabilities enable the observation of application behavior and performance under failure within a simulated future-generation HPC system using the most common fault handling technique.

  14. Pulsed-laser heating: a tool for studying degradation of materials subjected to repeated high-temperature excursions

    SciTech Connect (OSTI)

    Goldberg, A.; Cornell, R.H.

    1980-08-21T23:59:59.000Z

    The use of pulsed-laser heating was evaluated as a means to obtain high cyclic peak temperatures with short rise times. A two-stage neodymium glass laser was used which produces a 600-..mu..s pulse with energy outputs of up to 100 J. Small disk-shaped samples of AISI 4340 steel served as targets. Some of these were coated with a tungsten deposit. The rear face of some of the targets was instrumented for evaluation of temperature, strain, and stress response. Post-shot metallographic evaluations were made on a number of targets. We saw evidence of surface melting, cracking, and phase transformation. Surface damage was related to differences in the number of pulse cycles and input energy level, variables in the target materials, and the extent of strain-induced stresses. These experiments were performed in air at 1 atm and ambient laboratory temperature. 36 figures.

  15. Workflow Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengtheningWildfires may contribute more to &83 3.3 Table3WorkToolsTools

  16. Development of a HT Seismic Tool

    Broader source: Energy.gov [DOE]

    The program objective is to design; fabricate and field test two high temperature (HT) seismic tools in an EGS application.

  17. Slide system for machine tools

    DOE Patents [OSTI]

    Douglass, S.S.; Green, W.L.

    1980-06-12T23:59:59.000Z

    The present invention relates to a machine tool which permits the machining of nonaxisymmetric surfaces on a workpiece while rotating the workpiece about a central axis of rotation. The machine tool comprises a conventional two-slide system (X-Y) with one of these slides being provided with a relatively short travel high-speed auxiliary slide which carries the material-removing tool. The auxiliary slide is synchronized with the spindle speed and the position of the other two slides and provides a high-speed reciprocating motion required for the displacement of the cutting tool for generating a nonaxisymmetric surface at a selected location on the workpiece.

  18. Downhole tool

    DOE Patents [OSTI]

    Hall, David R.; Muradov, Andrei; Pixton, David S.; Dahlgren, Scott Steven; Briscoe, Michael A.

    2007-03-20T23:59:59.000Z

    A double shouldered downhole tool connection comprises box and pin connections having mating threads intermediate mating primary and secondary shoulders. The connection further comprises a secondary shoulder component retained in the box connection intermediate a floating component and the primary shoulders. The secondary shoulder component and the pin connection cooperate to transfer a portion of makeup load to the box connection. The downhole tool may be selected from the group consisting of drill pipe, drill collars, production pipe, and reamers. The floating component may be selected from the group consisting of electronics modules, generators, gyroscopes, power sources, and stators. The secondary shoulder component may comprises an interface to the box connection selected from the group consisting of radial grooves, axial grooves, tapered grooves, radial protrusions, axial protrusions, tapered protrusions, shoulders, and threads.

  19. System Software and Tools for High Performance Computing Environments: A report on the findings of the Pasadena Workshop, April 14--16, 1992

    SciTech Connect (OSTI)

    Sterling, T. [Universities Space Research Association, Washington, DC (United States); Messina, P. [Jet Propulsion Lab., Pasadena, CA (United States); Chen, M. [Yale Univ., New Haven, CT (United States)] [and others

    1993-04-01T23:59:59.000Z

    The Pasadena Workshop on System Software and Tools for High Performance Computing Environments was held at the Jet Propulsion Laboratory from April 14 through April 16, 1992. The workshop was sponsored by a number of Federal agencies committed to the advancement of high performance computing (HPC) both as a means to advance their respective missions and as a national resource to enhance American productivity and competitiveness. Over a hundred experts in related fields from industry, academia, and government were invited to participate in this effort to assess the current status of software technology in support of HPC systems. The overall objectives of the workshop were to understand the requirements and current limitations of HPC software technology and to contribute to a basis for establishing new directions in research and development for software technology in HPC environments. This report includes reports written by the participants of the workshop`s seven working groups. Materials presented at the workshop are reproduced in appendices. Additional chapters summarize the findings and analyze their implications for future directions in HPC software technology development.

  20. FLUID: Improving Throughputs in Enterprise Wireless LANs through Flexible Channelization

    E-Print Network [OSTI]

    Liblit, Ben

    the usefulness of flexible channels in the context of 802.11-based networks. Current 802.11 hardware can provideFLUID: Improving Throughputs in Enterprise Wireless LANs through Flexible Channelization Shravan for designing 802.11 wireless LANs (WLANs) using flexible channelization -- the choice of an appropriate channel

  1. Storage Performance Virtualization via Throughput and Latency Control

    E-Print Network [OSTI]

    Riska, Alma

    Storage Performance Virtualization via Throughput and Latency Control JIANYONG ZHANG, ANAND storage systems. A consequence of this trend is the need to serve multiple users and/or workloads of the underlying storage system; (2) couple rate and latency allocation in a single scheduler, making them less

  2. On the Throughput Capacity of Heterogeneous Wireless Networks

    E-Print Network [OSTI]

    Latchman, Haniph A.

    On the Throughput Capacity of Heterogeneous Wireless Networks Pan Li, Member, IEEE, and Yuguang of wireless networks. However, it is commonly assumed that all nodes in the network are identical. The issue of heterogeneous wireless networks with general network settings. Specifically, we consider an extended network

  3. Maximizing Throughput in Wireless Networks with Finite Internal Buffers

    E-Print Network [OSTI]

    Chang, Cheng-Shang

    Maximizing Throughput in Wireless Networks with Finite Internal Buffers Ching-Min Lien, Cheng of a discrete-time wireless network, where only certain sets of links can transmit simultaneously. It is well of the configuration vectors determines the capacity region of the wireless network. In the literature, packet

  4. Dynamic Power Allocation For Maximizing Throughput in Energy Harvesting

    E-Print Network [OSTI]

    Vaze, Rahul

    1 Dynamic Power Allocation For Maximizing Throughput in Energy Harvesting Communication System general case of arbitrarily varying energy arrivals is considered, where neither the future energy arrival strategy that invests available energy uniformly over all remaining slots until the next energy arrival

  5. Applying Speculative Technique to Improve TCP Throughput over Lossy Links

    E-Print Network [OSTI]

    Atiquzzaman, Mohammed

    @ou.edu Abstract-- The throughput degradation of Transport Control Protocol (TCP) over lossy links due performance due to control hazards in CPU design. First, two types of loss events in networks with lossy links links are involved in TCP connections. The objective of this paper is to propose a protocol

  6. Enhanced resolution and throughput of Fresnel incoherent correlation holography (FINCH)

    E-Print Network [OSTI]

    Rosen, Joseph

    Enhanced resolution and throughput of Fresnel incoherent correlation holography (FINCH) using dual Montgomery County Campus, Rockville, Maryland 20850, USA * barakk@ee.bgu.ac.il Abstract: Fresnel incoherent Fresnel holography," Opt. Lett. 32(8), 912­914 (2007). 7. J. Rosen and G. Brooker, "Fluorescence

  7. Applying Speculative Technique to Improve TCP Throughput over Lossy Links

    E-Print Network [OSTI]

    Minnesota, University of

    , Mohammed Atiquzzaman Honeywell Labs 3660 Technology Drive Minneapolis, MN 55418, USA E-mail: haowei.bai@honeywell #12;Applying Speculative Technique to Improve TCP Throughput over Lossy Links Haowei Bai Honeywell Labs 3660 Technology Drive Minneapolis, MN 55418 haowei.bai@honeywell.com David Lilja Electrical

  8. Improving Bluetooth EDR Data Throughput Using FEC and Interleaving

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Improving Bluetooth EDR Data Throughput Using FEC and Interleaving Ling-Jyh Chen1 , Tony Sun2 Enhanced Data Rate (EDR) mode detailed in the new Bluetooth spec v2.0. We first studied the APT algorithm/IFEC coding schemes for the new EDR packet types, assessed their ability to alleviate the impact of burst

  9. High Sensitivity Proteomics Assisted Discovery of a Novel Operon...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the water oxidation reactions of the photosynthetic electron transport chain in plants, algae, and cyanobacteria. Utilizing a high-throughput proteomic analysis of isolated PSII...

  10. ascidiacea high genome: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Daniel S. (Daniel Southwick), 1977- 2004-01-01 3 Data Management for High-Throughput Genomics CERN Preprints Summary: Today's sequencing technology allows sequencing an individual...

  11. A TRANSPORTATION RISK ASSESSMENT TOOL FOR ANALYZING THE TRANSPORT OF SPENT NUCLEAR FUEL AND HIGH-LEVEL RADIOACTIVE WASTE TO THE PROPOSED YUCCA MOUNTAIN REPOSITORY

    SciTech Connect (OSTI)

    NA

    2001-02-15T23:59:59.000Z

    The Yucca Mountain Draft Environmental Impact Statement (DEIS) analysis addressed the potential for transporting spent nuclear fuel and high-level radioactive waste from 77 origins for 34 types of spent fuel and high-level radioactive waste, 49,914 legal weight truck shipments, and 10,911 rail shipments. The analysis evaluated transportation over 59,250 unique shipment links for travel outside Nevada (shipment segments in urban, suburban or rural zones by state), and 22,611 links in Nevada. In addition, the analysis modeled the behavior of 41 isotopes, 1091 source terms, and used 8850 food transfer factors (distinct factors by isotope for each state). The analysis also used mode-specific accident rates for legal weight truck, rail, and heavy haul truck by state, and barge by waterway. This complex mix of data and information required an innovative approach to assess the transportation impacts. The approach employed a Microsoft{reg_sign} Access database tool that incorporated data from many sources, including unit risk factors calculated using the RADTRAN IV transportation risk assessment computer program. Using Microsoft{reg_sign} Access, the analysts organized data (such as state-specific accident and fatality rates) into tables and developed queries to obtain the overall transportation impacts. Queries are instructions to the database describing how to use data contained in the database tables. While a query might be applied to thousands of table entries, there is only one sequence of queries that is used to calculate a particular transportation impact. For example, the incident-free dose to off-link populations in a state is calculated by a query that uses route segment lengths for each route in a state that could be used by shipments, populations for each segment, number of shipments on each segment, and an incident-free unit risk factor calculated using RADTRAN IV. In addition to providing a method for using large volumes of data in the calculations, the queries provide a straight-forward means used to verify results. Another advantage of using the MS Access database was the ability to develop query hierarchies using nested queries. Calculations were broken into a series of steps, each step represented by a query. For example, the first query might calculate the number of shipment kilometers traveled through urban, rural and suburban zones for all states. Subsequent queries could join the shipment kilometers query results with another table containing unit risk factors calculated using RADTRAN IV to produce radiological impacts. Through the use of queries, impacts by origin, mode, fuel type or many other parameters can be obtained. The paper will show both the flexibility of the assessment tool and the ease it provides for verifying results.

  12. On Optimal Throughput-Energy Curve for Multi-hop Wireless Networks

    E-Print Network [OSTI]

    Hou, Y. Thomas

    Laboratory Washington, DC, USA Abstract--Network throughput and energy consumption are two important throughput under some energy constraint or minimizing energy consumption while satisfying some throughput, through- put and energy consumption are two key performance metrics that bear in the minds of network

  13. Workflow Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del SolStrengtheningWildfires may contribute more to &83 3.3 Table3WorkTools

  14. Modelling the Impact of User Mobility on the Throughput in Networks of Wireless 802.11 LANs

    E-Print Network [OSTI]

    van der Mei, Rob

    Modelling the Impact of User Mobility on the Throughput in Networks of Wireless 802.11 LANs Sandjai The Netherlands Email: sbhulai@few.vu.nl Rob van der Mei a,b b CWI Advanced Communication Networks P.O. Box 94079@feweb.vu.nl Abstract-- The wireless LAN technology 802.11, also called Wi-Fi, offers high speed wireless Internet

  15. irm-EAMS routine measurements: high precision; high accuracy; high throughput

    E-Print Network [OSTI]

    Eurovector EA allows to exchange the reactors separately (and fast). Exchange of the Mg(ClO4)2 water traps and selective CO2 trapping; Improved halide robustness of the combustion reactor using CeO2., Rapid Comm. Mass) inside the EA are exchanged regularly. On the CE-EA, combustion and reduction reactors are always

  16. EFFECTS OF SCHEDULING AND SPACING TOOLS ON CONTROLLERS' PERFORMANCE AND PERCEPTIONS OF THEIR WORKLOAD

    E-Print Network [OSTI]

    operations earned cautiously acceptable ratings, indicating the prototype tools have value. The goals level of throughput at airports and improving the efficiency of traffic management in dense terminal] and Europe (Single European Sky Air Traffic Management Research) [5, 6] aims to develop trajectory management

  17. Operational Simulation Tools and Long Term Strategic Planning...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Operational Simulation Tools and Long Term Strategic Planning for High Penetrations of PV in the Southeastern U.S. Operational Simulation Tools and Long Term Strategic Planning for...

  18. Tools | Department of Energy

    Office of Environmental Management (EM)

    Tools Tools logofemp.png The Federal Energy Management Program (FEMP) offers links to tools that can help agencies reduce energy use and meet federal laws and requirements. Tools...

  19. In: Proceedings of the 2005 IEEE International Symposium on Workload Characterization (IISWC), October 2005, c IEEE Comprehensive Throughput Evaluation of LANs in Clusters of PCs

    E-Print Network [OSTI]

    characteristics of net- works for clusters. A first microbenchmark tests the basic pro- cessing limitations. A second microbenchmark tests arbitrary communication pat- terns by pairwise connecting nodes for high-speed throughput tests. A third and slightly more realistic microbenchmark ex- ecutes an all-to-all personalised

  20. A Transportation Risk Assessment Tool for Analyzing the Transport of Spent Nuclear Fuel and High-Level Radioactive Waste to the Proposed Yucca Mountain Repository

    SciTech Connect (OSTI)

    Ralph Best; T. Winnard; S. Ross; R. Best

    2001-08-17T23:59:59.000Z

    The Yucca Mountain Transportation Database was developed as a data management tool for assembling and integrating data from multiple sources to compile the potential transportation impacts presented in the Draft Environmental Impact Statement for a Geologic Repository for the Disposal of Spent Nuclear Fuel and High-Level Radioactive Waste at Yucca Mountain, Nye County, Nevada (DEIS). The database uses the results from existing models and codes such as RADTRAN, RISKIND, INTERLINE, and HIGHWAY to estimate transportation-related impacts of transporting spent nuclear fuel and high-level radioactive waste from commercial reactors and U. S. Department of Energy (DOE) facilities to Yucca Mountain. The source tables in the database are compendiums of information from many diverse sources including: radionuclide quantities for each waste type; route and route characteristics for rail, legal-weight truck, heavy haul. truck, and barge transport options; state-specific accident and fatality rates for routes selected for analysis; packaging and shipment data by waste type; unit risk factors; the complex behavior of the packaged waste forms in severe transport accidents; and the effects of exposure to radiation or the isotopic specific effects of radionclides should they be released in severe transportation accidents. The database works together with the codes RADTRAN (Neuhauser, et al, 1994) and RISKlND (Yuan, et al, 1995) to calculate incident-free dose and accident risk. For the incident-free transportation scenario, the database uses RADTRAN and RISKIND-generated data to calculate doses to offlink populations, onlink populations, people at stops, crews, inspectors, workers at intermodal transfer stations, guards at overnight stops, and escorts, as well as non-radioactive pollution health effects. For accident scenarios, the database uses RADTRAN-generated data to calculate dose risks based on ingestion, inhalation, resuspension, immersion (cloudshine), and groundshine as well as non-radioactive traffic fatalities. The Yucca Mountain EIS Transportation Database was developed using Microsoft Access 97{trademark} software and the Microsoft Windows NT{trademark} operating system. The database consists of tables for storing data, forms for selecting data for querying, and queries for retrieving the data in a predefined format. Database queries retrieve records based on input parameters and are used to calculate incident-free and accident doses using unit risk factors obtained from RADTRAN results. The next section briefly provides some background that led to the development of the database approach used in preparing the Yucca Mountain DEIS. Subsequent sections provide additional details on the database structure and types of impacts calculated using the database.

  1. Automated Steel Cleanliness Analysis Tool (ASCAT)

    SciTech Connect (OSTI)

    Gary Casuccio (RJ Lee Group); Michael Potter (RJ Lee Group); Fred Schwerer (RJ Lee Group); Dr. Richard J. Fruehan (Carnegie Mellon University); Dr. Scott Story (US Steel)

    2005-12-30T23:59:59.000Z

    The objective of this study was to develop the Automated Steel Cleanliness Analysis Tool (ASCATTM) to permit steelmakers to evaluate the quality of the steel through the analysis of individual inclusions. By characterizing individual inclusions, determinations can be made as to the cleanliness of the steel. Understanding the complicating effects of inclusions in the steelmaking process and on the resulting properties of steel allows the steel producer to increase throughput, better control the process, reduce remelts, and improve the quality of the product. The ASCAT (Figure 1) is a steel-smart inclusion analysis tool developed around a customized next-generation computer controlled scanning electron microscopy (NG-CCSEM) hardware platform that permits acquisition of inclusion size and composition data at a rate never before possible in SEM-based instruments. With built-in customized ''intelligent'' software, the inclusion data is automatically sorted into clusters representing different inclusion types to define the characteristics of a particular heat (Figure 2). The ASCAT represents an innovative new tool for the collection of statistically meaningful data on inclusions, and provides a means of understanding the complicated effects of inclusions in the steel making process and on the resulting properties of steel. Research conducted by RJLG with AISI (American Iron and Steel Institute) and SMA (Steel Manufactures of America) members indicates that the ASCAT has application in high-grade bar, sheet, plate, tin products, pipes, SBQ, tire cord, welding rod, and specialty steels and alloys where control of inclusions, whether natural or engineered, are crucial to their specification for a given end-use. Example applications include castability of calcium treated steel; interstitial free (IF) degasser grade slag conditioning practice; tundish clogging and erosion minimization; degasser circulation and optimization; quality assessment/steel cleanliness; slab, billet or bloom disposition; and alloy development. Additional benefits of ASCAT include the identification of inclusions that tend to clog nozzles or interact with refractory materials. Several papers outlining the benefits of the ASCAT have been presented and published in the literature. The paper entitled ''Inclusion Analysis to Predict Casting Behavior'' was awarded the American Iron and Steel Institute (AISI) Medal in 2004 for special merit and importance to the steel industry. The ASCAT represents a quantum leap in inclusion analysis and will allow steel producers to evaluate the quality of steel and implement appropriate process improvements. In terms of performance, the ASCAT (1) allows for accurate classification of inclusions by chemistry and morphological parameters, (2) can characterize hundreds of inclusions within minutes, (3) is easy to use (does not require experts), (4) is robust, and (5) has excellent image quality for conventional SEM investigations (e.g., the ASCAT can be utilized as a dual use instrument). In summary, the ASCAT will significantly advance the tools of the industry and addresses an urgent and broadly recognized need of the steel industry. Commercialization of the ASCAT will focus on (1) a sales strategy that leverages our Industry Partners; (2) use of ''technical selling'' through papers and seminars; (3) leveraging RJ Lee Group's consulting services, and packaging of the product with a extensive consulting and training program; (4) partnering with established SEM distributors; (5) establishing relationships with professional organizations associated with the steel industry; and (6) an individualized plant by plant direct sales program.

  2. Development and implementation of a remote audit tool for high dose rate (HDR) Ir-192 brachytherapy using optically stimulated luminescence dosimetry

    SciTech Connect (OSTI)

    Casey, Kevin E.; Kry, Stephen F.; Howell, Rebecca M.; Followill, David [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030 (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030 (United States); Alvarez, Paola; Lawyer, Ann [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)

    2013-11-15T23:59:59.000Z

    Purpose: The aim of this work was to create a mailable phantom with measurement accuracy suitable for Radiological Physics Center (RPC) audits of high dose-rate (HDR) brachytherapy sources at institutions participating in National Cancer Institute-funded cooperative clinical trials. Optically stimulated luminescence dosimeters (OSLDs) were chosen as the dosimeter to be used with the phantom.Methods: The authors designed and built an 8 Ś 8 Ś 10 cm{sup 3} prototype phantom that had two slots capable of holding Al{sub 2}O{sub 3}:C OSLDs (nanoDots; Landauer, Glenwood, IL) and a single channel capable of accepting all {sup 192}Ir HDR brachytherapy sources in current clinical use in the United States. The authors irradiated the phantom with Nucletron and Varian {sup 192}Ir HDR sources in order to determine correction factors for linearity with dose and the combined effects of irradiation energy and phantom characteristics. The phantom was then sent to eight institutions which volunteered to perform trial remote audits.Results: The linearity correction factor was k{sub L}= (?9.43 Ś 10{sup ?5}Ś dose) + 1.009, where dose is in cGy, which differed from that determined by the RPC for the same batch of dosimeters using {sup 60}Co irradiation. Separate block correction factors were determined for current versions of both Nucletron and Varian {sup 192}Ir HDR sources and these vendor-specific correction factors differed by almost 2.6%. For the Nucletron source, the correction factor was 1.026 [95% confidence interval (CI) = 1.023–1.028], and for the Varian source, it was 1.000 (95% CI = 0.995–1.005). Variations in lateral source positioning up to 0.8 mm and distal/proximal source positioning up to 10 mm had minimal effect on dose measurement accuracy. The overall dose measurement uncertainty of the system was estimated to be 2.4% and 2.5% for the Nucletron and Varian sources, respectively (95% CI). This uncertainty was sufficient to establish a ±5% acceptance criterion for source strength audits under a formal RPC audit program. Trial audits of four Nucletron sources and four Varian sources revealed an average RPC-to-institution dose ratio of 1.000 (standard deviation = 0.011).Conclusions: The authors have created an OSLD-based {sup 192}Ir HDR brachytherapy source remote audit tool which offers sufficient dose measurement accuracy to allow the RPC to establish a remote audit program with a ±5% acceptance criterion. The feasibility of the system has been demonstrated with eight trial audits to date.

  3. Tools and Strategies to Data Understanding

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    may be interchangeable. VisualizationAnalyticsVisit Matlab Python tools: Numpy, Scipy, iPython, matplotlib Paraview Mathematica Perl IDL Python TCLTK... Read More peg High...

  4. TNA Data Collection Tool

    Broader source: Energy.gov [DOE]

    The TNA Data Collection Tool Instructions provides guidance on how to complete the TNA Data Collection Tool. The TNA Data Collection Tool is an Excel spreadsheet that the organization's designating training POC will use to populate their organizations training needs.

  5. The power tool

    SciTech Connect (OSTI)

    HAYFIELD, J.P.

    1999-02-01T23:59:59.000Z

    POWER Tool--Planning, Optimization, Waste Estimating and Resourcing tool, a hand-held field estimating unit and relational database software tool for optimizing disassembly and final waste form of contaminated systems and equipment.

  6. SMOV3B WFPC2 UV Contamination Monitoring and Throughput Check

    E-Print Network [OSTI]

    Sirianni, Marco

    1 SMOV3B WFPC2 UV Contamination Monitoring and Throughput Check A. M. Koekemoer, S. Gonzaga, L is potentially susceptible to significant decreases as a result of contaminants deposited on the cold CCD windows intensive monitoring of this contamination using the F170W filter, to ensure that the throughput never

  7. Throughput-Lifetime Tradeoffs in Multihop Wireless Networks under an SINR-based

    E-Print Network [OSTI]

    Rosenberg, Catherine P.

    1 Throughput-Lifetime Tradeoffs in Multihop Wireless Networks under an SINR-based Interference crucial design objectives for a number of multihop wireless network applica- tions. As these two this tradeoff between the network throughput and lifetime, for the case of fixed wireless networks where link

  8. Improving TCP Throughput over Lossy Links Using Protocol-Level Speculations

    E-Print Network [OSTI]

    Minnesota, University of

    Improving TCP Throughput over Lossy Links Using Protocol-Level Speculations Haowei Bai Honeywell@ou.edu Abstract-- The degradation of Transport Control Protocol (TCP) throughput in networks with lossy links. This is very similar to processor performance degradation due to control hazards in CPU design. First, two

  9. High throughput parallel backside contacting and periodic texturing for high-efficiency solar cells

    DOE Patents [OSTI]

    Daniel, Claus; Blue, Craig A.; Ott, Ronald D.

    2014-08-19T23:59:59.000Z

    Disclosed are configurations of long-range ordered features of solar cell materials, and methods for forming same. Some features include electrical access openings through a backing layer to a photovoltaic material in the solar cell. Some features include textured features disposed adjacent a surface of a solar cell material. Typically the long-range ordered features are formed by ablating the solar cell material with a laser interference pattern from at least two laser beams.

  10. Screening for high-performance piezoelectrics using high-throughput density functional theory

    E-Print Network [OSTI]

    Armiento, Rickard R.

    We present a large-scale density functional theory (DFT) investigation of the ABO3 chemical space in the perovskite crystal structure, with the aim of identifying those that are relevant for forming piezoelectric materials. ...

  11. High throughput screen for cells with high extracellular metabolite consumption--secretion rates using microfluidic droplets

    E-Print Network [OSTI]

    Wang, Benjamin L. (Benjamin Lu chen)

    2009-01-01T23:59:59.000Z

    Metabolic engineering has contributed significantly to the improvement of strains for the industrial production of various compounds. Traditionally, enzymatic steps closely associated with the product-forming pathway have ...

  12. Ultra-high-aspect-ratio nanofluidic channels for high-throughput biological applications

    E-Print Network [OSTI]

    Mao, Pan

    2009-01-01T23:59:59.000Z

    The development of micro/nanofluidics is expected to be the enabling technology for sample preparation of proteomic biosamples, which has been the bottleneck in proteomics. Most microfabricated nanofluidic channels, such ...

  13. Bayesian Model Selection for High-dimensional High-throughput Data

    E-Print Network [OSTI]

    Joshi, Adarsh

    2012-07-16T23:59:59.000Z

    LIST OF TABLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . x LIST OF FIGURES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi CHAPTER I INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . 1 II... BAYESIAN HYPOTHESIS TESTING USING TEST STATISTICS 7 2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.3 Bayes? factors based on test statistics: testing...

  14. Foundational Tools for Petascale Computing

    SciTech Connect (OSTI)

    Miller, Barton

    2014-05-19T23:59:59.000Z

    The Paradyn project has a history of developing algorithms, techniques, and software that push the cutting edge of tool technology for high-end computing systems. Under this funding, we are working on a three-year agenda to make substantial new advances in support of new and emerging Petascale systems. The overall goal for this work is to address the steady increase in complexity of these petascale systems. Our work covers two key areas: (1) The analysis, instrumentation and control of binary programs. Work in this area falls under the general framework of the Dyninst API tool kits. (2) Infrastructure for building tools and applications at extreme scale. Work in this area falls under the general framework of the MRNet scalability framework. Note that work done under this funding is closely related to work done under a contemporaneous grant, “High-Performance Energy Applications and Systems”, SC0004061/FG02-10ER25972, UW PRJ36WV.

  15. Planning Tool for Strategic Evaluation of Facility Plans - 13570

    SciTech Connect (OSTI)

    Magoulas, Virginia; Cercy, Michael [Savannah River National Laboratory, Savannah River Site, Aiken, SC 29808 (United States)] [Savannah River National Laboratory, Savannah River Site, Aiken, SC 29808 (United States); Hall, Irin [Newport News Shipbuilding, 4101 Washington Ave., Newport News, VA 23607 (United States)] [Newport News Shipbuilding, 4101 Washington Ave., Newport News, VA 23607 (United States)

    2013-07-01T23:59:59.000Z

    Savannah River National Laboratory (SRNL) has developed a strategic planning tool for the evaluation of the utilization of its unique resources for processing and research and development of nuclear materials. The Planning Tool is a strategic level tool for assessing multiple missions that could be conducted utilizing the SRNL facilities and showcasing the plan. Traditional approaches using standard scheduling tools and laying out a strategy on paper tended to be labor intensive and offered either a limited or cluttered view for visualizing and communicating results. A tool that can assess the process throughput, duration, and utilization of the facility was needed. SRNL teamed with Newport News Shipbuilding (NNS), a division of Huntington Ingalls Industries, to create the next generation Planning Tool. The goal of this collaboration was to create a simulation based tool that allows for quick evaluation of strategies with respect to new or changing missions, and clearly communicates results to the decision makers. This tool has been built upon a mature modeling and simulation software previously developed by NNS. The Planning Tool provides a forum for capturing dependencies, constraints, activity flows, and variable factors. It is also a platform for quickly evaluating multiple mission scenarios, dynamically adding/updating scenarios, generating multiple views for evaluating/communicating results, and understanding where there are areas of risks and opportunities with respect to capacity. The Planning Tool that has been developed is useful in that it presents a clear visual plan for the missions at the Savannah River Site (SRS). It not only assists in communicating the plans to SRS corporate management, but also allows the area stakeholders a visual look at the future plans for SRS. The design of this tool makes it easily deployable to other facility and mission planning endeavors. (authors)

  16. Applications (Grid Tools)

    E-Print Network [OSTI]

    Buyya, Rajkumar

    Grid Fabric Software Grid Applications Core Grid Middleware User-Level Middleware (Grid Tools) !"# $ %& ' ( ) * #& + '& ' , - . / # ) ) 0 # * 1 PDB CDB Grid Fabric Hardware &+ '' + ) , '1 '1 ' % - * # ( Grid Fabric Software Grid Applications Core Grid Middleware User-Level Middleware (Grid Tools) !"# $ %& ' ( ) * #& + '& ' , - . / # ) ) 0

  17. OOTW COST TOOLS

    SciTech Connect (OSTI)

    HARTLEY, D.S.III; PACKARD, S.L.

    1998-09-01T23:59:59.000Z

    This document reports the results of a study of cost tools to support the analysis of Operations Other Than War (OOTW). It recommends the continued development of the Department of Defense (DoD) Contingency Operational Support Tool (COST) as the basic cost analysis tool for 00TWS. It also recommends modifications to be included in future versions of COST and the development of an 00TW mission planning tool to supply valid input for costing.

  18. Adjustable cutting tool holder

    SciTech Connect (OSTI)

    Steinhour, William Lee III; West, Drew; Honeycutt, Steve; Frank, Steven; Krishnamurthy, Kallutla

    2000-09-21T23:59:59.000Z

    This patent application describes a device for varying the geometry of a cutting tool for use in machining operations.

  19. A direct-write thick-film lithography process for multi-parameter control of tooling in continuous roll-to-roll microcontact printing

    E-Print Network [OSTI]

    Nietner, Larissa F

    2014-01-01T23:59:59.000Z

    Roll-to-roll (R2R) microcontact printing ([mu]CP) aims to transform micron-precision soft lithography in a continuous, large-scale, high-throughput process for large-area surface patterning, flexible electronics and ...

  20. Throughput Optimal Scheduling in the Presence of Heavy-Tailed Traffic

    E-Print Network [OSTI]

    Jagannathan, Krishna Prasanna

    We investigate the tail behavior of the steady-state queue occupancies under throughput optimal scheduling in the presence of heavy-tailed traffic. We consider a system consisting of two parallel queues, served by a single ...

  1. Table Set-up with Modern Engineering Tools Target Aud ience: Parents of elementary school students (grades 3-6) and Middle and High School Students

    E-Print Network [OSTI]

    Linhardt, Robert J.

    of a 40 lumen equivalent LED bulb (cluster of single LEDs) attached , the Lamp specifications spreadsheet (grades 3-6) and Middle and High School Students Objectives: 1. Introduce LED technology and design by using the USB Microscope. 2. Introduce the LED and bulb as an efficient alternative to conventional

  2. Wachs Cutter Tooling Station (4495)

    Broader source: Energy.gov (indexed) [DOE]

    purchase, build and install Wachs cutter tooling. The Wachs Cutter Tooling Station is similar to previously operated facility tooling and will utilize an existing hydraulic unit....

  3. Rotary fast tool servo system and methods

    DOE Patents [OSTI]

    Montesanti, Richard C. (Cambridge, MA); Trumper, David L. (Plaistow, NH)

    2007-10-02T23:59:59.000Z

    A high bandwidth rotary fast tool servo provides tool motion in a direction nominally parallel to the surface-normal of a workpiece at the point of contact between the cutting tool and workpiece. Three or more flexure blades having all ends fixed are used to form an axis of rotation for a swing arm that carries a cutting tool at a set radius from the axis of rotation. An actuator rotates a swing arm assembly such that a cutting tool is moved in and away from the lathe-mounted, rotating workpiece in a rapid and controlled manner in order to machine the workpiece. A pair of position sensors provides rotation and position information for a swing arm to a control system. A control system commands and coordinates motion of the fast tool servo with the motion of a spindle, rotating table, cross-feed slide, and in-feed slide of a precision lathe.

  4. Machine tool locator

    DOE Patents [OSTI]

    Hanlon, John A. (Los Alamos, NM); Gill, Timothy J. (Stanley, NM)

    2001-01-01T23:59:59.000Z

    Machine tools can be accurately measured and positioned on manufacturing machines within very small tolerances by use of an autocollimator on a 3-axis mount on a manufacturing machine and positioned so as to focus on a reference tooling ball or a machine tool, a digital camera connected to the viewing end of the autocollimator, and a marker and measure generator for receiving digital images from the camera, then displaying or measuring distances between the projection reticle and the reference reticle on the monitoring screen, and relating the distances to the actual position of the autocollimator relative to the reference tooling ball. The images and measurements are used to set the position of the machine tool and to measure the size and shape of the machine tool tip, and examine cutting edge wear. patent

  5. Deployment of a Suite of High-Performance Computational Tools for Multi-scale Multi-physics Simulation of Generation IV Reactors

    SciTech Connect (OSTI)

    Podowski, Michael Z

    2013-01-03T23:59:59.000Z

    The overall objective of this project has been to deploy advanced simulation capabilities for next generation reactor systems utilizing newly available, high-performance computing facilities. The approach includes the following major components: The development of new simulation capabilities using state-of-the-art computer codes of different scales: molecular dynamics (MD) level, DNS (FronTier and PHASTA) and CFD (NPHASE-CMFD); The development of advanced numerical solvers for large-size computational problems; The deployment of a multiple-code computational platform for multiscale simulations of gas/liquid two-phase flow during reactor transients and accidents; and Application of the new computational methodology to study the progression of loss-of-flow accident in sodium fast reactor (SFR).

  6. Leveraging on Easy Java Simulation tool and open source computer simulation library to create interactive digital media for mass customization of high school physics curriculum

    E-Print Network [OSTI]

    Wee, Loo Kang

    2012-01-01T23:59:59.000Z

    This paper highlights the diverse possibilities in the rich community of educators from the Conceptual Learning of Science (CoLoS) and Open Source Physics (OSP) movement to engage, enable and empower educators and students, to create interactive digital media through computer modeling. This concept revolves around a paradigmatic shift towards participatory learning through immersive computer modeling, as opposed to using technology for information transmission. We aim to engage high school educators to professionally develop themselves by creating and customizing simulations possible through Easy Java Simulation (Ejs) and its learning community. Ejs allows educators to be designers of learning environments through modifying source codes of the simulation. Educators can conduct lessons with students' using these interactive digital simulations and rapidly enhance the simulation through changing the source codes personally. Ejs toolkit, its library of simulations and growing community contributed simulation cod...

  7. Certification Status Search Tool

    E-Print Network [OSTI]

    Certification Status Search Tool (SB/DVBE) Illustrated User Manual #12;2 Certification Status Search Tool (SB/DVBE) Rev. 5/14/09 Copyright © 2008 RFP Depot, LLC dba BidSync All Rights Reserved://www.bidsync.com #12;3 Certification Status Search Tool (SB/DVBE) Rev. 5/14/09 Introduction BidSync is a powerful e

  8. Moving Large Data Sets Over High-Performance Long Distance Networks

    SciTech Connect (OSTI)

    Hodson, Stephen W [ORNL; Poole, Stephen W [ORNL; Ruwart, Thomas [ORNL; Settlemyer, Bradley W [ORNL

    2011-04-01T23:59:59.000Z

    In this project we look at the performance characteristics of three tools used to move large data sets over dedicated long distance networking infrastructure. Although performance studies of wide area networks have been a frequent topic of interest, performance analyses have tended to focus on network latency characteristics and peak throughput using network traffic generators. In this study we instead perform an end-to-end long distance networking analysis that includes reading large data sets from a source file system and committing large data sets to a destination file system. An evaluation of end-to-end data movement is also an evaluation of the system configurations employed and the tools used to move the data. For this paper, we have built several storage platforms and connected them with a high performance long distance network configuration. We use these systems to analyze the capabilities of three data movement tools: BBcp, GridFTP, and XDD. Our studies demonstrate that existing data movement tools do not provide efficient performance levels or exercise the storage devices in their highest performance modes. We describe the device information required to achieve high levels of I/O performance and discuss how this data is applicable in use cases beyond data movement performance.

  9. Wireline logging tool catalog

    SciTech Connect (OSTI)

    Verdier, M.

    1986-01-01T23:59:59.000Z

    This book provides discussions on wireline logging tools. The contents are resistivity, radioactivity, acoustic, formation dip and borehold geometry, formation sampling, and auxiliary services.

  10. High Througput Combinatorial Techniques in Hydrogen Storage Materials...

    Broader source: Energy.gov (indexed) [DOE]

    and surface area measurements (high-throughput techniques need development). 5. Aerogels Page 2 of 5 Synthesis is based on standard sol-gel processes and should be similar to...

  11. 21T High Resolution Mass Accuracy Capability | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    mass analyzer with co-located capabilities in high - throughput omics, imaging, and microfluidics. The 21T FTICR MS will be the best, if not the only, capability in the world to...

  12. Chip breaking system for automated machine tool

    DOE Patents [OSTI]

    Arehart, Theodore A. (Clinton, TN); Carey, Donald O. (Oak Ridge, TN)

    1987-01-01T23:59:59.000Z

    The invention is a rotary selectively directional valve assembly for use in an automated turret lathe for directing a stream of high pressure liquid machining coolant to the interface of a machine tool and workpiece for breaking up ribbon-shaped chips during the formation thereof so as to inhibit scratching or other marring of the machined surfaces by these ribbon-shaped chips. The valve assembly is provided by a manifold arrangement having a plurality of circumferentially spaced apart ports each coupled to a machine tool. The manifold is rotatable with the turret when the turret is positioned for alignment of a machine tool in a machining relationship with the workpiece. The manifold is connected to a non-rotational header having a single passageway therethrough which conveys the high pressure coolant to only the port in the manifold which is in registry with the tool disposed in a working relationship with the workpiece. To position the machine tools the turret is rotated and one of the tools is placed in a material-removing relationship of the workpiece. The passageway in the header and one of the ports in the manifold arrangement are then automatically aligned to supply the machining coolant to the machine tool workpiece interface for breaking up of the chips as well as cooling the tool and workpiece during the machining operation.

  13. Fluid sampling tool

    DOE Patents [OSTI]

    Johnston, Roger G. (Los Alamos, NM); Garcia, Anthony R. E. (Espanola, NM); Martinez, Ronald K. (Santa Cruz, NM)

    2001-09-25T23:59:59.000Z

    The invention includes a rotatable tool for collecting fluid through the wall of a container. The tool includes a fluid collection section with a cylindrical shank having an end portion for drilling a hole in the container wall when the tool is rotated, and a threaded portion for tapping the hole in the container wall. A passageway in the shank in communication with at least one radial inlet hole in the drilling end and an opening at the end of the shank is adapted to receive fluid from the container. The tool also includes a cylindrical chamber affixed to the end of the shank opposite to the drilling portion thereof for receiving and storing fluid passing through the passageway. The tool also includes a flexible, deformable gasket that provides a fluid-tight chamber to confine kerf generated during the drilling and tapping of the hole. The invention also includes a fluid extractor section for extracting fluid samples from the fluid collecting section.

  14. OOTW Force Design Tools

    SciTech Connect (OSTI)

    Bell, R.E.; Hartley, D.S.III; Packard, S.L.

    1999-05-01T23:59:59.000Z

    This report documents refined requirements for tools to aid the process of force design in Operations Other Than War (OOTWs). It recommends actions for the creation of one tool and work on other tools relating to mission planning. It also identifies the governmental agencies and commands with interests in each tool, from whom should come the user advisory groups overseeing the respective tool development activities. The understanding of OOTWs and their analytical support requirements has matured to the point where action can be taken in three areas: force design, collaborative analysis, and impact analysis. While the nature of the action and the length of time before complete results can be expected depends on the area, in each case the action should begin immediately. Force design for OOTWs is not a technically difficult process. Like force design for combat operations, it is a process of matching the capabilities of forces against the specified and implied tasks of the operation, considering the constraints of logistics, transport and force availabilities. However, there is a critical difference that restricts the usefulness of combat force design tools for OOTWs: the combat tools are built to infer non-combat capability requirements from combat capability requirements and cannot reverse the direction of the inference, as is required for OOTWs. Recently, OOTWs have played a larger role in force assessment, system effectiveness and tradeoff analysis, and concept and doctrine development and analysis. In the first Quadrennial Defense Review (QDR), each of the Services created its own OOTW force design tool. Unfortunately, the tools address different parts of the problem and do not coordinate the use of competing capabilities. These tools satisfied the immediate requirements of the QDR, but do not provide a long-term cost-effective solution.

  15. SOFTWARE Open Access The HTS barcode checker pipeline, a tool for

    E-Print Network [OSTI]

    Kaski, Samuel

    of trade in endangered species, and can aid in safeguarding these species from extinction in the wild traded species from high-throughput sequencing data Youri Lammers1 , Tamara Peelen2 , Rutger A Vos1 contain parts of species protected by the Convention on International Trade in Endangered Species of Wild

  16. Global Solar Opportunity Tool: A Tool for Policy Makers and Energy...

    Open Energy Info (EERE)

    Global Solar Opportunity Tool: A Tool for Policy Makers and Energy Analysts Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Global Solar Opportunity Tool: A Tool for...

  17. A Deeply Pipelined CABAC Decoder for HEVC Supporting Level 6.2 High-tier Applications

    E-Print Network [OSTI]

    Chen, Yu-Hsin

    High Efficiency Video Coding (HEVC) is the latest video coding standard that specifies video resolutions up to 8K Ultra-HD (UHD) at 120 fps to support the next decade of video applications. This results in high-throughput ...

  18. Cluster Computing: High-Performance, High-Availability, and High-Throughput Processing on a Network of Computers

    E-Print Network [OSTI]

    Buyya, Rajkumar

    Laboratory Dept. of Computer Science and Software Engineering The University of Melbourne, Australia {csyeo, raj}@cs.mu.oz.au 2 Parallel and Distributed Systems Laboratory Department of Computer Science for cluster computing was developed in the 1960s by IBM as an alternative of linking large mainframes

  19. advanced control tools: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    systems. This tool has been applied to the control of a high purity distillation column also modeled in SIMULINK including non linear hydrodynamic effects. Also LabVIEW...

  20. Computational Tools to Accelerate Commercial Development

    SciTech Connect (OSTI)

    Miller, David C.

    2013-01-01T23:59:59.000Z

    The goals of the work reported are: to develop new computational tools and models to enable industry to more rapidly develop and deploy new advanced energy technologies; to demonstrate the capabilities of the CCSI Toolset on non-proprietary case studies; and to deploy the CCSI Toolset to industry. Challenges of simulating carbon capture (and other) processes include: dealing with multiple scales (particle, device, and whole process scales); integration across scales; verification, validation, and uncertainty; and decision support. The tools cover: risk analysis and decision making; validated, high-fidelity CFD; high-resolution filtered sub-models; process design and optimization tools; advanced process control and dynamics; process models; basic data sub-models; and cross-cutting integration tools.

  1. Minds, Brains and Tools 

    E-Print Network [OSTI]

    Clark, Andy

    2002-01-01T23:59:59.000Z

    The selected texts for this discussion were two recent pieces by Dennett (“Things About Things” and “Making Tools for Thinking” – henceforth TAT and MTT respectively) and one oldie-but-goodie (“Styles of Mental Representation”, ...

  2. Friction stir welding tool

    DOE Patents [OSTI]

    Tolle, Charles R. (Idaho Falls, ID); Clark, Denis E. (Idaho Falls, ID); Barnes, Timothy A. (Ammon, ID)

    2008-04-15T23:59:59.000Z

    A friction stir welding tool is described and which includes a shank portion; a shoulder portion which is releasably engageable with the shank portion; and a pin which is releasably engageable with the shoulder portion.

  3. Sandia Modeling Tool Webinar

    Broader source: Energy.gov [DOE]

    Hosted by the Energy Department and Western Area Power Administration, this webinar will show attendees about what collaborative, stakeholder-driven modeling is and how the modeling tools and process developed by Sandia can be used in Indian Country.

  4. UNIX Public Tools

    Broader source: Energy.gov [DOE]

    SATAN, the System Administrator Tool for Analyzing Networks, is a network security analyzer designed by Dan Farmer and Wietse Venema. SATAN scans systems connected to the network noting the...

  5. Smart tool holder

    DOE Patents [OSTI]

    Day, Robert Dean (Los Alamos, NM); Foreman, Larry R. (Los Alamos, NM); Hatch, Douglas J. (Los Alamos, NM); Meadows, Mark S. (Boston, MA)

    1998-01-01T23:59:59.000Z

    There is provided an apparatus for machining surfaces to accuracies within the nanometer range by use of electrical current flow through the contact of the cutting tool with the workpiece as a feedback signal to control depth of cut.

  6. PPA Tools and Update

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PPA Tools & Update Chandra Shah chandra.shah@nel.gov October 21, 2010 2 | FEDERAL ENERGY MANAGEMENT PROGRAM femp.energy.gov * PPA (15 minutes) - Resources - Discussion * URESC (15...

  7. Modeling of Tool Wear and Tool Fracture in Micromilling

    E-Print Network [OSTI]

    Shiosaki, Dominic

    2012-02-14T23:59:59.000Z

    of aluminum and titanium. Finite element analysis and tool modeling compliment experimental data. Cumulative tool wear based on Taylor model shows decreasing tool life with increasing feed rate and increasing cutting speed on aluminum. Inconsistent results...

  8. Analytic expressions for atomic layer deposition: Coverage, throughput, and materials utilization in cross-flow, particle coating, and spatial atomic layer deposition

    SciTech Connect (OSTI)

    Yanguas-Gil, Angel; Elam, Jeffrey W., E-mail: jelam@anl.gov [Argonne National Laboratory, Energy Systems Division, 9700 S Cass Ave, Lemont, Illinois 60439 (United States)

    2014-05-15T23:59:59.000Z

    In this work, the authors present analytic models for atomic layer deposition (ALD) in three common experimental configurations: cross-flow, particle coating, and spatial ALD. These models, based on the plug-flow and well-mixed approximations, allow us to determine the minimum dose times and materials utilization for all three configurations. A comparison between the three models shows that throughput and precursor utilization can each be expressed by universal equations, in which the particularity of the experimental system is contained in a single parameter related to the residence time of the precursor in the reactor. For the case of cross-flow reactors, the authors show how simple analytic expressions for the reactor saturation profiles agree well with experimental results. Consequently, the analytic model can be used to extract information about the ALD surface chemistry (e.g., the reaction probability) by comparing the analytic and experimental saturation profiles, providing a useful tool for characterizing new and existing ALD processes.

  9. 2005 International Conference on Wireless Networks, Communications and Mobile Computing Improving TCP Throughput over Lossy Links Using

    E-Print Network [OSTI]

    Atiquzzaman, Mohammed

    TCP Throughput over Lossy Links Using Protocol-Level Speculations Haowei Bai Honeywell Labs 3660- The degradation of Transport Control Protocol (TCP) throughput in networks with lossy links is mainly due to processor performance degradation due to control hazards in CPU design. First, two types of loss events

  10. Data Mining Tools Irfan Altas

    E-Print Network [OSTI]

    Turlach, Berwin A.

    Data Mining Tools Irfan Altas School of Information Studies, Charles Sturt University Wagga Wagga discuss several scalable and parallel discovery and predictive data mining tools. They successfully Data mining tools, thin plate splines, BMARS, revolver, regression, smoothing, addi­ tive models

  11. Boosted top: experimental tools overview

    E-Print Network [OSTI]

    Emanuele Usai; for the ATLAS; CMS Collaborations

    2015-01-05T23:59:59.000Z

    An overview of tools and methods for the reconstruction of high-boost top quark decays at the LHC is given in this report. The focus is on hadronic decays, in particular an overview of the current status of top quark taggers in physics analyses is presented. The most widely used jet substructure techniques, normally used in combination with top quark taggers, are reviewed. Special techniques to treat pileup in large cone jets are described, along with a comparison of the performance of several boosted top quark reconstruction techniques.

  12. Program Development Tools and Infrastructures

    SciTech Connect (OSTI)

    Schulz, M

    2012-03-12T23:59:59.000Z

    Exascale class machines will exhibit a new level of complexity: they will feature an unprecedented number of cores and threads, will most likely be heterogeneous and deeply hierarchical, and offer a range of new hardware techniques (such as speculative threading, transactional memory, programmable prefetching, and programmable accelerators), which all have to be utilized for an application to realize the full potential of the machine. Additionally, users will be faced with less memory per core, fixed total power budgets, and sharply reduced MTBFs. At the same time, it is expected that the complexity of applications will rise sharply for exascale systems, both to implement new science possible at exascale and to exploit the new hardware features necessary to achieve exascale performance. This is particularly true for many of the NNSA codes, which are large and often highly complex integrated simulation codes that push the limits of everything in the system including language features. To overcome these limitations and to enable users to reach exascale performance, users will expect a new generation of tools that address the bottlenecks of exascale machines, that work seamlessly with the (set of) programming models on the target machines, that scale with the machine, that provide automatic analysis capabilities, and that are flexible and modular enough to overcome the complexities and changing demands of the exascale architectures. Further, any tool must be robust enough to handle the complexity of large integrated codes while keeping the user's learning curve low. With the ASC program, in particular the CSSE (Computational Systems and Software Engineering) and CCE (Common Compute Environment) projects, we are working towards a new generation of tools that fulfill these requirements and that provide our users as well as the larger HPC community with the necessary tools, techniques, and methodologies required to make exascale performance a reality.

  13. Route Throughput Analysis with Spectral Reuse for Multi-Rate Mobile Ad Hoc Networks

    E-Print Network [OSTI]

    Tseng, Yu-Chee

    networks (MANETs) have received a lot of attention for its flexible network architecture. While many network (MANET) is a flexible and dynamic architecture that is attractive due to its ease in network1 Route Throughput Analysis with Spectral Reuse for Multi-Rate Mobile Ad Hoc Networks Lien-Wu Chen

  14. Joint Power Control and Link Scheduling in Wireless Networks for Throughput Optimization

    E-Print Network [OSTI]

    Huang, Jianwei

    Joint Power Control and Link Scheduling in Wireless Networks for Throughput Optimization Liqun Fu--This paper concerns the problem of finding the minimum-length TDMA frame of a power-controlled wire- less formulate the general joint link scheduling and power control problem as an in- teger linear programming

  15. Throughput Optimization in Multi-hop Wireless Networks with Multi-packet Reception and

    E-Print Network [OSTI]

    Jayaweera, Sudharman K.

    Mexico College, Espanola, NM - USA Electrical & Computer Engineering Dept., University of New Mexico layer have enabled the simultaneous reception of multiple packets by a node in wireless net- works. We model for the throughput optimization in MPR-capable wireless net- works, where nodes have one or more

  16. Accounting for Memory Use, Cost, Throughput, and Latency in the Design of a Media Server

    E-Print Network [OSTI]

    Chang, Edward Y.

    : the per­stream costs and the worst­case initial latency before a new media request can be satisfied. WeAccounting for Memory Use, Cost, Throughput, and Latency in the Design of a Media Server Edward scheduling and data place­ ment ones. We show that, some disk latency reduction techniques can

  17. SCHEDULING ABOVE MAC TO MAXIMIZE BATTERY LIFETIME AND THROUGHPUT IN WLANS

    E-Print Network [OSTI]

    Simunic, Tajana

    SCHEDULING ABOVE MAC TO MAXIMIZE BATTERY LIFETIME AND THROUGHPUT IN WLANS Edoardo Regini, Daeseob Diego La Jolla, CA 92093 {eregini, dalim, tajana}@ucsd.edu ABSTRACT Maximizing battery lifetime. This is because in heavy traffic conditions, the chance of nodes to successfully transmit a packet decreases

  18. Throughput Validation of an Advanced Channel Assignment Algorithm in IEEE 802.11 Mohamad Haidar

    E-Print Network [OSTI]

    Akl, Robert

    assignment for hot-spot service areas in a WLAN by formulating an Integer Linear Programming (ILP) modelThroughput Validation of an Advanced Channel Assignment Algorithm in IEEE 802.11 WLAN Mohamad channel-assignment algorithm at the Access Points (APs) of a Wireless Local Area Network (WLAN

  19. Effect of Height (Fresnel Clearance) on Signal Strength and Throughput for

    E-Print Network [OSTI]

    Liblit, Ben

    Effect of Height (Fresnel Clearance) on Signal Strength and Throughput for Medium and Long Distance obstruction height · Ignoring Fresnel Clearance For 20Km long Wireless Link, Fresnel Clearance requires around, height 4 m at Q ensures 100% Fresnel Clearance On Physical Inspection: No LOS even at 8 meters Distance

  20. Cherish every Joule: Maximizing throughput with an eye on network-wide energy consumption

    E-Print Network [OSTI]

    Hou, Y. Thomas

    Cherish every Joule: Maximizing throughput with an eye on network-wide energy consumption Canming: {jcm, yshi, thou, wjlou}@vt.edu Abstract Conserving network-wide energy consumption is becoming of wireless networks, the concern of energy consumption is becoming in- creasingly important for network

  1. Figure 2 Analysis Tool Interface Level-1 / PBBT Analysis Tool

    E-Print Network [OSTI]

    Figure 2 ­ Analysis Tool Interface Level-1 / PBBT Analysis Tool Introduction The Level-1/PBBT Analysis Tool (LPAT) was designed to assist in the analysis of North American Standard Level-1 Inspection. The data incorporated into the tool includes the results of Level-1 inspections with accompanying PBBT test

  2. High Efficiency, Low Cost Solar Cells Manufactured Using 'Silicon Ink' on Thin Crystalline Silicon Wafers

    SciTech Connect (OSTI)

    Antoniadis, H.

    2011-03-01T23:59:59.000Z

    Reported are the development and demonstration of a 17% efficient 25mm x 25mm crystalline Silicon solar cell and a 16% efficient 125mm x 125mm crystalline Silicon solar cell, both produced by Ink-jet printing Silicon Ink on a thin crystalline Silicon wafer. To achieve these objectives, processing approaches were developed to print the Silicon Ink in a predetermined pattern to form a high efficiency selective emitter, remove the solvents in the Silicon Ink and fuse the deposited particle Silicon films. Additionally, standard solar cell manufacturing equipment with slightly modified processes were used to complete the fabrication of the Silicon Ink high efficiency solar cells. Also reported are the development and demonstration of a 18.5% efficient 125mm x 125mm monocrystalline Silicon cell, and a 17% efficient 125mm x 125mm multicrystalline Silicon cell, by utilizing high throughput Ink-jet and screen printing technologies. To achieve these objectives, Innovalight developed new high throughput processing tools to print and fuse both p and n type particle Silicon Inks in a predetermined pat-tern applied either on the front or the back of the cell. Additionally, a customized Ink-jet and screen printing systems, coupled with customized substrate handling solution, customized printing algorithms, and a customized ink drying process, in combination with a purchased turn-key line, were used to complete the high efficiency solar cells. This development work delivered a process capable of high volume producing 18.5% efficient crystalline Silicon solar cells and enabled the Innovalight to commercialize its technology by the summer of 2010.

  3. Flow-Through Microfluidic Device for High-Efficiency Transfection of Mammalian Cells through Combined Microelectroporation and Sonoporation

    E-Print Network [OSTI]

    Longsine, Whitney Leigh

    2012-07-16T23:59:59.000Z

    In this study we are presenting a proof-of-concept microfluidic device that simultaneously applies the conditions required for microelectroporation and micro-sonoporation in a flow-through fashion that allows for high throughput, high efficiency...

  4. Drum lid removal tool

    DOE Patents [OSTI]

    Pella, Bernard M. (Martinez, GA); Smith, Philip D. (North Augusta, SC)

    2010-08-24T23:59:59.000Z

    A tool for removing the lid of a metal drum wherein the lid is clamped over the drum rim without protruding edges, the tool having an elongated handle with a blade carried by an angularly positioned holder affixed to the midsection of the handle, the blade being of selected width to slice between lid lip and the drum rim and, when the blade is so positioned, upward motion of the blade handle will cause the blade to pry the lip from the rim and allow the lid to be removed.

  5. Tools | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently AskedEnergyIssuesEnergy SolarRadioactiveI Disposal Sites25, 2015ToolkitTools Tools

  6. Tools | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn'tOriginEducationVideoStrategic|Industrial Sector,DepartmentFebruary 19, 2015TonyTools for theTools

  7. ComparativeComparative InteractomicsInteractomics comparative genomics of high throughput data

    E-Print Network [OSTI]

    Utrecht, Universiteit

    of quality of expert curation (to use as source or reference) and most prolific HTP data (complex mean absence of co- complex membership #12;Estimating absence of interactions from HTP dataEstimating absence of interactions from HTP data --> yeast; what do we call an absence of interaction data> yeast

  8. Real Time Pulse Pile-up Recovery in a High Throughput Digital Pulse Processor

    SciTech Connect (OSTI)

    Scoullar, Paul A. B.; McLean, Chris C. [Southern Innovation, Melbourne (Australia); Evans, Rob J. [Department of Electrical and Electronic Engineering, University of Melbourne (Australia)

    2011-12-13T23:59:59.000Z

    Detection and measurement of radiation is used extensively for non-invasive material characterization in a range of industries. However, many practical applications are frustrated by pulse pile-up within the detector. Pulse pile-up, which occurs when multiple radiation events arrive within the temporal resolving time of the detector, degrades the fidelity of subsequent material analysis. Traditional pulse processing techniques use fast digital filters and logic circuits to detect piled-up events and discard the corrupted data, however, this leads to substantial detector dead time. Consequently, there is considerable interest in more complex signal-processing algorithms to extend the performance of pulse processors and improve material characterization techniques. We present a technology for real-time decoding of pulse pile-up events. It is a model-based signal-processing algorithm able to accurately characterize the number, time-of-arrival and energy of all events in the detector output. Even in the presence of severe multi-pulse pile-up, the composite events are decoded and the energy and time-of-arrival recovered. The technology has been evaluated using a range of detectors, sources and count rates. An exceptional improvement over traditional pulse processing techniques is demonstrated.

  9. High-throughput screening of shape memory alloy thin-film spreads using nanoindentation

    E-Print Network [OSTI]

    Rubloff, Gary W.

    -film libraries. Nanoindentation was performed on Ni­Mn­Al ternary composition spreads. The indentation hardness and Wyrobek3 recently set forth a series of guidelines for the use of a nanoindenter to screen combina- torial

  10. High-Throughput Automated Luminescent Magnetic Particle-Based Immunoassay to Monitor

    E-Print Network [OSTI]

    Hammock, Bruce D.

    immunoassay de- scribed here is sensitive, simple to use, and more rapid than the previously reported standard significantly reduce the time and labor required for chromato- graphic separation and detection of multiple

  11. Examination of mammalian microRNAs by high-throughput sequencing

    E-Print Network [OSTI]

    Chiang, HyoJin Rosaria

    2011-01-01T23:59:59.000Z

    Small non-coding RNAs play an important role in a wide range of cellular events. MicroRNAs (miRNAs) are an abundant class of small RNAs that post-transcriptionally repress expression of their target genes. Since miRNA ...

  12. Development of a high throughput 3D perfused liver tissue bioreactor

    E-Print Network [OSTI]

    Inman, Samuel Walker

    2006-01-01T23:59:59.000Z

    This thesis describes the development of a device designed for culturing liver tissue in a 3D perfused environment. Cells form tissue inside miniature channels of a scaffold, and the tissue is perfused with culture medium ...

  13. Database Requirements for Workflow Management in a HighThroughput Genome Laboratory 1

    E-Print Network [OSTI]

    Bonner, Anthony

    @genome.wi.mit.edu 2 University of Toronto Department of Computer Science 10 King's College Rd Toronto, ON, Canada M5S constitutes an audit trail, or event history, and has much the same function as a laboratory notebook number P50 HG00098, and from the U.S. Department of Energy under contract DE­FG02­95ER62101. 1 #12

  14. LabFlow1: a Database Benchmark for HighThroughput Workflow Management ?

    E-Print Network [OSTI]

    Bonner, Anthony

    @db.toronto.edu Adel Shrufi 1 shrufi@db.toronto.edu Steve Rozen 2 steve@genome.wi.mit.edu 1 University of Toronto of workflow activity. This DBMS maintains an audit trail, or event history, that records the results of each Genome Research, grant number P50 HG00098, and from the U.S. Department of Energy under contract DE­FG02

  15. LabFlow1: a Database Benchmark for HighThroughput Workflow Management \\Lambda

    E-Print Network [OSTI]

    Bonner, Anthony

    University of Toronto Department of Computer Science 10 King's College Rd Toronto, ON, Canada M5S 1A4 2 track of workflow activity. This DBMS maintains an audit trail, or event history, that records number P50 HG00098, and from the U.S. Department of Energy under contract DE­FG02­95ER62101. #12

  16. High-throughput approaches to sourcing of human hepatocytes for cell-based therapies

    E-Print Network [OSTI]

    Shan, Jing (Jing Meghan)

    2014-01-01T23:59:59.000Z

    Chronic liver disease affects more than 500 million people worldwide. The only therapy shown to directly prevent mortality is organ transplantation. However, there is growing discrepancy between supply and demand of ...

  17. The Development of a High-throughput Microdroplet Bioreactor Device for Microbial Studies

    E-Print Network [OSTI]

    Guzman, Adrian

    2012-10-19T23:59:59.000Z

    Current PCR Polymerase Chain Reaction MOS-FET Metal-Oxide-Semiconductor Field-Effect Transistor BSA Bovine Serum Albumin GFP Green Fluorescent Protein RFP Red Fluorescent Protein LED Light Emitting Diode PMT Photomultiplier Tubes...

  18. Ultra-high Throughput Real-time Instruments for Capturing Fast Signals and Rare Events

    E-Print Network [OSTI]

    Buckley, Brandon Walter

    2013-01-01T23:59:59.000Z

    from non-linear regression. . . . . . . . . . Conceptually,was estimated from non-linear regression. Un-Equalized RealRF band- width. A non-linear regression estimated the chirp

  19. Identification of GPR65, a novel regulator of matrix metalloproteinases using high through-put screening

    SciTech Connect (OSTI)

    Xu, Hongbo; Chen, Xiaohong; Huang, Junwei [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China)] [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China); Deng, Weiwei [Functional Genomics Group, Chinese National Human Genome Center (CHGB) at Beijing (China)] [Functional Genomics Group, Chinese National Human Genome Center (CHGB) at Beijing (China); Zhong, Qi [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China)] [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China); Yue, Changli [Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing (China)] [Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing (China); Wang, Pingzhang, E-mail: wangpzh@bjmu.edu.cn [Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University Center for Human Disease Genomics, Key Laboratory of Medical Immunology, Ministry of Health (China) [Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University Center for Human Disease Genomics, Key Laboratory of Medical Immunology, Ministry of Health (China); Functional Genomics Group, Chinese National Human Genome Center (CHGB) at Beijing (China); Huang, Zhigang, E-mail: enthuangzhigang@sohu.com [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China)] [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China)

    2013-06-21T23:59:59.000Z

    Highlights: •A novel mechanism of MMP3 regulation by proton-sensing G-protein-coupled receptors was defined. •GPR65 was identified to induce the MMP3 expression. •GPR65 mediated MMP induction under acidic conditions. •AP-1 binding site in MMP3 promoter was crucial for MMP3 induction. •GPR65 overexpression can accelerate the invision of A549 cells. -- Abstract: Matrix metalloproteinases (MMPs) are over-expressed in nearly all cancers. To study novel regulatory factors of MMP expression in head and neck cancer (HNC), we screened a total of 636 candidate genes encoding putative human transmembrane proteins using MMP promoter reporter in a dual luciferase assay system. Three genes GPR65, AXL and TNFRSF10B dramatically activated the induction of MMP3 expression. The induction of MMP expression by GPR65 was further confirmed in A549 and/or FaDu cells. GPR65 mediated MMP induction under acidic conditions. The AP-1 binding site in MMP3 promoter was crucial for MMP3 induction. Moreover, the A549 cells infected by recombinant adenovirus of GPR65 showed accelerated cell invasion. In conclusion, we validate that GPR65 is vital regulatory genes upstream of MMP3, and define a novel mechanism of MMP3 regulation by proton-sensing G-protein-coupled receptors.

  20. High-throughput single-molecule fluorescence spectroscopy using parallel detection

    E-Print Network [OSTI]

    Michalet, Xavier

    -molecule imaging). In this section, we briefly discuss the technique and data analysis used in standard solution-based , S. Tisad , F. Zappad , S. Covad , S. Weissa a Dept of Chemistry & Biochemistry, Los Angeles, CA, USA 90095; b Nesher Technologies, Los Angeles, CA; c Dept of Physics & Astronomy, UCLA, Los Angeles, CA

  1. High-throughput metal nanoparticle catalysis by pulsed laser ablation Selim Senkan a,*, Michael Kahn a

    E-Print Network [OSTI]

    Senkan, Selim M.

    of propylene. In less than a day, over 40 different catalytic materials of nanoparticles supported on g-Al2O3 oxidation products of propylene with one-pass yields of about 13% at 275 8C. # 2006 Published by Elsevier B of propylene oxide from propylene, hydrogen and oxygen [5]. On the other hand, larger Au nanoparticles result

  2. A high-throughput three-dimensional cell migration assay for toxicity screening

    E-Print Network [OSTI]

    Diseases, University of Texas Health Science Center, Houston, TX 77030 USA. There is a growing demand,19­21 . These nanoparticles are nontoxic and do not induce an inflammatory cytokine (IL-6, IL-8) response by cells22 they interact and aggregate with each other to form larger 3D cultures. This method has been shown to induce

  3. High-throughput microfluidic living cell arrays for spatiotemporal gene expression profiling

    E-Print Network [OSTI]

    King, Kevin R. (Kevin Robert), 1976-

    2008-01-01T23:59:59.000Z

    The cellular microenvironment is remarkably complex. In the small space near each cell, growth factors are liberated from extracellular matrix, cytokines are secreted from neighboring cells, and hormones arrive from distant ...

  4. Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray

    E-Print Network [OSTI]

    Hook, Andrew L.

    Atomic force microscopy has been applied to an acrylate polymer microarray to achieve a full topographic characterisation. This process discovered a small number of hydro-responsive materials created from monomers with ...

  5. Development and Application of a High Throughput Methodology to Characterize and Formulate Protein-Based Therapeutics

    E-Print Network [OSTI]

    Hu, Lei

    2012-12-31T23:59:59.000Z

    simultaneously, including UV absorption, light scattering, and near- and far- UV CD by employing a multimodal spectrometer (Chapter 2). Fluorescence spectral data are also collected on the same instrument although not simultaneously. The method is developed...

  6. analyzing high-throughput sequencing: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    biological sample analysis abundance variabilities within sample cohorts. Mass spectrometry (MS) based platforms have attracted Clemmer, David E. 11 The use of coded PCR...

  7. Integrated microfluidic device for single-cell high throughput screening in dynamic gene expression analysis

    E-Print Network [OSTI]

    Hui, Lawrence Kwan Yeung

    2008-01-01T23:59:59.000Z

    iv v vii ix x xii 3.3.1 Gradient Generation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

  8. High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors

    E-Print Network [OSTI]

    Davenport, Jason; Blach, Maurie; Galam, Lakshmi; Girgis, Antwan; Hall, Jessica; Blagg, Brian S. J.; Matts, Robert L.

    2014-03-03T23:59:59.000Z

    Hsp90 has become the target of intensive investigation, as inhibition of its function has the ability to simultaneously incapacitate proteins that function in pathways that represent the six hallmarks of cancer. While a ...

  9. A high-throughput microfluidic device to study neurite response to growth factor gradients

    E-Print Network [OSTI]

    Kothapalli, Chandrasekhar R.

    Studying neurite guidance by diffusible or substrate bound gradients is challenging with current techniques. In this study, we present the design, fabrication and utility of a microfluidic device to study neurite guidance ...

  10. Cyber-T web server: differential analysis of high-throughput data

    E-Print Network [OSTI]

    Kayala, M. A; Baldi, P.

    2012-01-01T23:59:59.000Z

    10.1093/nar/gks420 Cyber-T web server: differential analysisin the Cyber-T web server, is one of the most widelyan update to the Cyber-T web server, incorporating several

  11. Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics

    E-Print Network [OSTI]

    Hughes, Travis K.

    An innovative, microwell-based platform for single-cell RNA sequencing (RNA-seq) combines cost efficiency, scalability and parallelizability, and will enable many new avenues of biological inquiry.

  12. PVD synthesis and high-throughput property characterization of Ni?Fe?Cr alloy libraries

    SciTech Connect (OSTI)

    Rar, A.; Frafjord, J.J.; Fowlkes, Jason D.; Specht, E.D.; Rack, P.D.; Santella, M.L.; Bei, H.; George, E.P.; Pharr, G.M. (Tennessee-K); (Tennessee-K); (ORNL)

    2010-11-10T23:59:59.000Z

    Three methods of alloy library synthesis, thick-layer deposition followed by interdiffusion, composition-spread codeposition and electron-beam melting of thick deposited layers, have been applied to Ni-Fe-Cr ternary and Ni-Cr binary alloys. Structural XRD mapping and mechanical characterization by means of nanoindentation have been used to characterize the properties of the libraries. The library synthesis methods are compared from the point of view of the structural and mechanical information they can provide.

  13. Discovery and High-Throughput Screening of Heteroleptic Iridium Complexes for Photoinduced Hydrogen Production

    E-Print Network [OSTI]

    Bernhard, Stefan

    researchers. Simple solar devices focus or collect sunlight, harnessing radiation in order to heat dwellings December 3, 2004; E-mail: sbernhar@princeton.edu Abstract: The catalytic process of photoinduced hydrogen of the hydrogen evolution process and facilitated mechanistic studies. All six compounds investigated produced

  14. A GPU-Like Soft Processor for High-Throughput Acceleration

    E-Print Network [OSTI]

    Steffan, J. Gregory

    into a blade server platform, and XtremeData and Nallatech that offer FPGA accelerator modules that can of the implementation, testing, and debugging required for devel- oping real hardware. Behavioral synthesis techniques the advantages of (i) supporting a familiar programming model and environment and (ii) being portable across

  15. High throughput 3D optical microscopy : from image cytometry to endomicroscopy

    E-Print Network [OSTI]

    Choi, Heejin

    2014-01-01T23:59:59.000Z

    Optical microscopy is an imaging technique that allows morphological mapping of intracellular structures with submicron resolution. More importantly, optical microscopy is a technique that can readily provide images with ...

  16. High-throughput Characterization of Porous Materials Using Graphics Processing Units

    E-Print Network [OSTI]

    Kim, Jihan

    2013-01-01T23:59:59.000Z

    A.E. ; Purcell, T. Computer Graphics Forum 2007, 26(1), 80-of Porous Materials Using Graphics Processing Units Jihanof Porous Materials Using Graphics Processing Units Jihan

  17. Multi-Channel and Multi-Rate Adaptation for High-Throughput Wireless Networks

    E-Print Network [OSTI]

    Nguyen, Duy Duc

    2012-01-01T23:59:59.000Z

    layer. Unlike wired networks, wireless networks have to deal2 Background Wireless Networks Wireless technology is allWLAN), wireless mesh networks, wireless metropolitan area

  18. The Development of a High-throughput Microdroplet Bioreactor Device for Microbial Studies 

    E-Print Network [OSTI]

    Guzman, Adrian

    2012-10-19T23:59:59.000Z

    Current PCR Polymerase Chain Reaction MOS-FET Metal-Oxide-Semiconductor Field-Effect Transistor BSA Bovine Serum Albumin GFP Green Fluorescent Protein RFP Red Fluorescent Protein LED Light Emitting Diode PMT Photomultiplier Tubes...

  19. Lensfree Optical Tomography for High-Throughput 3D Imaging on a Chip

    E-Print Network [OSTI]

    ISIKMAN, SERHAN OMER

    2012-01-01T23:59:59.000Z

    microscope with light-emitting diode illumination. Opt.source such as a light emitting diode (LED). The fundamentalchip microscope, 24 light-emitting diodes (LEDs - each with

  20. Improving the Yeast Three-Hybrid System for High-Throughput Target Discovery

    E-Print Network [OSTI]

    Bailey, Kyle

    2011-05-27T23:59:59.000Z

    fluorescence produced with only the yEGFP reporter (light gray) and maximal fluorescence with reporter activated by a LexA-B42 fusion (dark gray). Taken with permission from (Clark, D. D.; Peterson, B. R. Chembiochem 2005, 6, 1442). ............ 28 Figure 2... of induced yeast lacking LexA-B42 (red histogram). C) Table of relevant statistics taken from histograms. The median signal and coefficient of variation (CV) is taken from the gated population of induced cells bearing the complete system (black histogram...

  1. HIGH-THROUGHPUT/COMBINATORIAL TECHNIQUES IN HYDROGEN STORAGE MATERIALS R&D WORKSHOP

    E-Print Network [OSTI]

    , academia, and national laboratories. The objectives of this meeting were to: · Assess the potential is solution-based with solids handling similar to proven combinatorial methods. Exploration of new structures-ray scattering (SAXS) to determine pore size (needs development), hydrogen uptake me

  2. An ultra-high throughput mutational spectrometer for human genetic diagnostics

    E-Print Network [OSTI]

    Forest, Craig Richard, 1978-

    2007-01-01T23:59:59.000Z

    Discovering the genetic causes of common diseases may require scanning for mutations in all of the genes in a million people, a significant undertaking. Such discoveries would revolutionize biotechnology, potentially ...

  3. Encoded hydrogel microparticles for high-throughput molecular diagnostics and personalized medicine

    E-Print Network [OSTI]

    Chapin, Stephen Clifford

    2012-01-01T23:59:59.000Z

    The ability to accurately detect and quantify biological molecules in complex mixtures is crucial in basic research as well as in clinical settings. Advancements in genetic analysis, molecular diagnostics, and patient-tailored ...

  4. SNP Calling Using Genotype Model Selection on High-Throughput Sequencing Data

    E-Print Network [OSTI]

    Murillo, Gabriel Hiroshi

    2012-01-01T23:59:59.000Z

    10, March 2009. [35] Heng Li. Fastq format specification.Accessed: 10/16/2012. [36] Heng Li. Pileup format. http://Ac- cessed: 10/16/2012. [37] Heng Li. Mathematical notes on

  5. Antibody-functionalized nanoporous surfaces enable high throughput specific cell capture

    E-Print Network [OSTI]

    Mittal, Sukant

    2012-01-01T23:59:59.000Z

    Adhesion-based cell capture on surfaces in microfluidic devices forms the basis of numerous biomedical diagnostics and in vitro assays. Solid surface microfluidic platforms have been widely explored for biomedical diagnostics ...

  6. Inch-Scale High Throughput Metrology of Graphene and Patterned Graphene Oxide

    E-Print Network [OSTI]

    Pleskot, Dennis

    2013-01-01T23:59:59.000Z

    Strength of Monolayer Graphene Science 2008 321, 385-388. 5.Novoselov, K. S. The rise of graphene Nature 2007 6 183-191.A. Thermal properties of graphene and nanostructured carbon

  7. A high-throughput in vivo micronucleus assay for genome instability screening in mice

    E-Print Network [OSTI]

    Balmus, Gabriel; Karp, Natasha A; Ng, Bee Ling; Jackson, Stephen P; Adams, David J; McIntyre, Rebecca E

    2014-12-31T23:59:59.000Z

    .jackson@gurdon.cam.ac.uk; Ng BL – bln@sanger.ac.uk; Adams DJ – da1@sanger.ac.uk; McIntyre R – rm5@sanger.ac.uk; Primary articles: 20 McIntyre, R.E. et al. Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome. PLoS Genet 8, e... into the mouse phenotyping pipeline, we have identified radiation-sensitive mutants, which exhibit increased levels of micronucleated-RET after irradiation but not before. Within this manuscript, 150 we provide additional details on data analysis...

  8. High Throughput Identification, Purification and Structural Characterization of Water Soluble Protein Complexes in Desulfovibrio vulgaris

    SciTech Connect (OSTI)

    Dong,, Ming; Han, Bong-Gyoon; Liu, Hui-Hai; Malik, J.; Geller, Jil; Yang, Li; Choi, M.; Chandonia, John-Marc; Arbelaez, Pablo; Sterling, H. J.; Typke, Dieter; Shatsky, Max; Brenner, Steve; Fisher, Susan; Williams, Evan; Szakal, Evelin; Allen, S.; Hall, S. C.; Hazen, Terry; Witkowska, H. E.; Jin, Jiming; Glaeser, Robert; Biggin, Mark

    2010-05-17T23:59:59.000Z

    Our scheme for the tagless purification of water soluble complexes. 10 g of protein from a crude bacterial extract is first fractionated by ammonium sulfate precipitation and then by a series of chromatographic steps: anion exchange (IEX), hydrophobic interaction (HIC), and finally size exclusion (Gel Filtration). Fractions from the last chromatography step are trypsin digested and peptides labeled with iTRAQ reagents to allow multiplexing and quantitation during mass spectrometric analysis. Elution profiles of identified proteins are then subjected to clustering analysis.

  9. High-throughput genomic analysis of virulence and resistance mechanisms among microbial pathogens

    E-Print Network [OSTI]

    Tewhey, Ryan Stephen

    2012-01-01T23:59:59.000Z

    al. (2010). Evolution of MRSA during hospital transmissionphylogenetic tree CA-MRSA isolates and the reference strainand antibiotic resistance costs by MRSA. The ISME journal 4,

  10. Automated detection and classification of circulating cancer cells via high-throughput microscopy

    E-Print Network [OSTI]

    Agustin, Ramses Martinez

    2007-01-01T23:59:59.000Z

    sample (1/100 dilution in MDA-MB-231) with highest positivesample (1/200 dilution in MDA-MB-231) with highest positivesample (1/200 dilution in MDA-MB-468) with highest positive

  11. High-throughput, single-worm tracking and analysis in Caenorhabditis elegans

    E-Print Network [OSTI]

    Yemini, Eviatar

    2013-01-08T23:59:59.000Z

    Microfluidic Environment. PLoS ONE 3, e2550 (2008). 18. Berri, S., Boyle, J. H., Tassieri, M., Hope, I. A. & Cohen, N. Forward locomotion of the nematode C. elegans is achieved through modulation of a single gait. HFSP J 3, 186–193 (2009). 19. Fang-Yen, C. et...

  12. Design and fabrication of a microfluidies gradient generator system for high-throughput molecular interaction studies

    E-Print Network [OSTI]

    Chen, Guan-Jong, 1981-

    2004-01-01T23:59:59.000Z

    Design and fabrication of a microfluidics system capable of generating reproducible and controlled micro-biochemical environments that can be used as a diagnostic assay and microreactor is important. Here, a simple technique ...

  13. Hybrid CMOS/Nanodevice Circuits for High Throughput Pattern Matching Applications

    E-Print Network [OSTI]

    Sherwood, Tim

    , Timothy Sherwood2 , and Dmitri B. Strukov1* 1 Electrical and Computer Engineering Department, University Figure 1. Pattern matching with island-type FPGA circuits: (a) general idea, and (b) matching operation addressable memories (T/CAMs) (Fig. 2) [8, 9]. These approaches rely on patterns being loaded into specially

  14. Application of High Throughput Pretreatment and Co-Hydrolysis System to Thermochemical

    E-Print Network [OSTI]

    California at Riverside, University of

    Introduction Sustainable energy sources are needed to supplement petroleum use in light of limited reserves economically, a large number of factors such as feedstock quality, conversion conditions, and catalyst loadings as well as their complex interactions must be better evaluated to identify combina- tions that can

  15. Polymer microfluidic device for high-throughput single-cell encapsulation, lysis, and biological assay

    E-Print Network [OSTI]

    Brackbill, Timothy Peter

    2012-01-01T23:59:59.000Z

    rheology through microfluidics,” Advanced Materials, vol.Berthier and P. Silberzan, Microfluidics for Biotechnology.A. P. Lee, “Droplet microfluidics,” Lab on a Chip, vol. 8,

  16. High-Throughput 3D Structural Homology Detection via NMR Resonance Christopher James Langmead

    E-Print Network [OSTI]

    Richardson, David

    is the number of residues in the tar- get protein and c is the maximum edge weight in an integer- weighted for two dissimilar amino acid sequences to fold to the "same" ter- tiary structure. For example, the RMSD

  17. A high-throughput, near-saturating screen for type III effector genes from Pseudomonas syringae

    E-Print Network [OSTI]

    Dangl, Jeff

    criteria defined 29 type III proteins from P. syringae pv. tomato, and 19 from P. syringae pv. phaseolicola [disease resistance (R) pro- teins], a battery of host responses is triggered, including localized

  18. The First Extrasolar Planet Discovered with a New Generation High Throughput Doppler Instrument

    E-Print Network [OSTI]

    Complutense de Madrid, Universidad

    was confirmed by radial velocity observations with the ET at the KPNO 2.1 m tele- scope and also at the 9 m is an effective method for planet detection. In addition, the ET concept is adaptable to multiple-object Doppler activity as the cause of the radial velocity variability. Our photometric observations rule out transits

  19. A microfluidics approach towards high-throughput pathogen removal from blood using margination

    E-Print Network [OSTI]

    Hou, Han Wei

    Sepsis is an adverse systemic inflammatory response caused by microbial infection in blood. This paper reports a simple microfluidic approach for intrinsic, non-specific removal of both microbes and inflammatory cellular ...

  20. High-throughput Microfluidics and Ultrafast Optics for in Vivo Compound/Genetic Discoveries

    E-Print Network [OSTI]

    Rohde, Christopher Benjamin

    Therapeutic treatment of spinal cord injuries, brain trauma, stroke, and neurodegenerative diseases will greatly benefit from the discovery of compounds that enhance neuronal regeneration following injury. We previously ...

  1. alphascreen high-throughput assay: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: provided a blueprint of the DNA present in each human cell, genomics research is now focusing on the study) Hybridizing these primers with the genomic...

  2. automated high-throughput assay: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: provided a blueprint of the DNA present in each human cell, genomics research is now focusing on the study) Hybridizing these primers with the genomic...

  3. Integrated microfluidic device for single-cell high throughput screening in dynamic gene expression analysis

    E-Print Network [OSTI]

    Hui, Lawrence Kwan Yeung

    2008-01-01T23:59:59.000Z

    P.J. , & Lee, L.P. , Microfluidics-based systems biology.T.M. & Quake, S.R. , Microfluidics: Fluid physics at theand applications of microfluidics in biology. Annu Rev

  4. Identification and correction of systematic error in high-throughput sequence data

    E-Print Network [OSTI]

    Meacham, Frazer; Boffelli, Dario; Dhahbi, Joseph; Martin, David IK; Singer, Meromit; Pachter, Lior

    2011-01-01T23:59:59.000Z

    The reads were mapped with Bowtie [10] allowing up to twothe refer- ence genome with Bowtie and refined our analysisto the virus genome using Bowtie, obtaining 382.2Ś coverage

  5. Novel SNP Discovery in African Buffalo, Syncerus caffer, Using High-Throughput Sequencing

    E-Print Network [OSTI]

    Steve Kemp

    and Bowtie software packages. A mean depth of 2.76 coverage over the mapped regions was obtained. Btau4 gene annotation was added to all SNPs identified within gene regions. Bowtie and BWA identified a maximum of 2 SNPs, 43­54% of the Bowtie SNPs and 57­58% of the BWA SNPs were confirmed as polymorphic. dN/dS ratios

  6. Characterization and High Throughput Analysis of Metal Hydrides for Hydrogen Storage

    E-Print Network [OSTI]

    Barcelo, Steven James

    2009-01-01T23:59:59.000Z

    Hydrides for Energy Storage. A.F. Andresen and A.J. Maeland,Metal Hydrides for Hydrogen Storage by Steven James BarceloMetal Hydrides for Hydrogen Storage by Steven James Barcelo

  7. High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury

    SciTech Connect (OSTI)

    Wills, Lauren P. [MitoHealth Inc., Charleston, SC 29403 (United States); Beeson, Gyda C.; Trager, Richard E.; Lindsey, Christopher C. [Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425 (United States); Beeson, Craig C. [MitoHealth Inc., Charleston, SC 29403 (United States); Peterson, Yuri K. [Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425 (United States); Schnellmann, Rick G., E-mail: schnell@musc.edu [Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425 (United States); Ralph H. Johnson VA Medical Center, Charleston, SC 29401 (United States)

    2013-10-15T23:59:59.000Z

    Many environmental chemicals and drugs negatively affect human health through deleterious effects on mitochondrial function. Currently there is no chemical library of mitochondrial toxicants, and no reliable methods for predicting mitochondrial toxicity. We hypothesized that discrete toxicophores defined by distinct chemical entities can identify previously unidentified mitochondrial toxicants. We used a respirometric assay to screen 1760 compounds (5 ?M) from the LOPAC and ChemBridge DIVERSet libraries. Thirty-one of the assayed compounds decreased uncoupled respiration, a stress test for mitochondrial dysfunction, prior to a decrease in cell viability and reduced the oxygen consumption rate in isolated mitochondria. The mitochondrial toxicants were grouped by chemical similarity and two clusters containing four compounds each were identified. Cheminformatic analysis of one of the clusters identified previously uncharacterized mitochondrial toxicants from the ChemBridge DIVERSet. This approach will enable the identification of mitochondrial toxicants and advance the prediction of mitochondrial toxicity for both drug discovery and risk assessment. - Highlights: • Respirometric assay conducted in RPTC to create mitochondrial toxicant database. • Chemically similar mitochondrial toxicants aligned as mitochondrial toxicophores • Mitochondrial toxicophore identifies five novel mitochondrial toxicants.

  8. High-Throughput Assay of 9 Lysosomal Enzymes for Newborn Screening

    E-Print Network [OSTI]

    Gelb, Michael

    : There is interest in newborn screening of lysosomal storage diseases (LSDs) because of the avail- ability with a cassette of substrates and internal standards and 1 or 2 punches of a dried blood spot (DBS) from a newborn used for MS/MS quantification in the selected reaction monitoring mode. RESULTS: Analysis of blood

  9. High Throughput Ab initio Modeling of Charge Transport for Bio-Molecular-Electronics

    E-Print Network [OSTI]

    Bruque, Nicolas A.

    2009-01-01T23:59:59.000Z

    DNA-Based Molecular Electronics. vol. 725. New York: AIP,Heath, “Whence molecular electronics? ” Science, vol. 306,model,” J. Computational Electronics, vol. 6, no. 4, pp.

  10. ORIGINAL PAPER The RABiT: high-throughput technology for assessing global DSB

    E-Print Network [OSTI]

    Brenner, David Jonathan

    . Turner · P. Sharma · J. R. Perrier · A. Bertucci · L. Smilenov · G. Johnson · M. Taveras · D. J. Brenner, and it has a H. C. Turner (&) Á P. Sharma Á J. R. Perrier Á A. Bertucci Á L. Smilenov Á G. Johnson Á M

  11. Analysis of High-Throughput Sequencing and Annotation Strategies for Phage Genomes

    E-Print Network [OSTI]

    Chisholm, Sallie (Penny)

    Background: Bacterial viruses (phages) play a critical role in shaping microbial populations as they influence both host mortality and horizontal gene transfer. As such, they have a significant impact on local and global ...

  12. High throughput lessons from the LHC experience.Johnston.TNC2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tier 1 centers into their computing clusters at universities ("Tier 2" centers) for analysis. 2 The management of this data - from CERN (Tier 0) to Tier 1 data center to Tier 2...

  13. SNP Calling Using Genotype Model Selection on High-Throughput Sequencing Data

    E-Print Network [OSTI]

    Murillo, Gabriel Hiroshi

    2012-01-01T23:59:59.000Z

    II [44] Atlas-SNP2 [59] inGAP [54] SAMtools [39] VarScan [and Stephan C. Schuster. inGAP: an in- tegrated next-

  14. Biochemical & Thermochemical High Throughput Characterization of Feedstocks Presentation for BETO 2015 Project Peer Review

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureCommentsEnergyand SustainedBio-Oil Deployment in the Home Heating 20

  15. Biochemical & Thermochemical High Throughput Characterization of Feedstocks for BETO 2015 Project Peer Review

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureCommentsEnergyand SustainedBio-Oil Deployment in the Home Heating 20

  16. First principles high throughput screening of oxynitrides for water-splitting photocatalysts

    E-Print Network [OSTI]

    Ceder, Gerbrand

    and eleven quaternary oxynitrides. Broader context Water-splitting photocatalysis directly converts the solar and Honda,1,2 the photocatalysis of water splitting has become an active research area and a promising way

  17. High-Throughput Screening Platform for Engineered Nanoparticle-Mediated Genotoxicity Using CometChip Technology

    E-Print Network [OSTI]

    Watson, Christa

    The likelihood of intentional and unintentional engineered nanoparticle (ENP) exposure has dramatically increased due to the use of nanoenabled products. Indeed, ENPs have been incorporated in many useful products and have ...

  18. Automated high-throughput flow-through real-time diagnostic system

    DOE Patents [OSTI]

    Regan, John Frederick

    2012-10-30T23:59:59.000Z

    An automated real-time flow-through system capable of processing multiple samples in an asynchronous, simultaneous, and parallel fashion for nucleic acid extraction and purification, followed by assay assembly, genetic amplification, multiplex detection, analysis, and decontamination. The system is able to hold and access an unlimited number of fluorescent reagents that may be used to screen samples for the presence of specific sequences. The apparatus works by associating extracted and purified sample with a series of reagent plugs that have been formed in a flow channel and delivered to a flow-through real-time amplification detector that has a multiplicity of optical windows, to which the sample-reagent plugs are placed in an operative position. The diagnostic apparatus includes sample multi-position valves, a master sample multi-position valve, a master reagent multi-position valve, reagent multi-position valves, and an optical amplification/detection system.

  19. Polymer microfluidic device for high-throughput single-cell encapsulation, lysis, and biological assay

    E-Print Network [OSTI]

    Brackbill, Timothy Peter

    2012-01-01T23:59:59.000Z

    is a valid assumption. The viscosity of the oil was alsoassumption is often wrong, be- Table 4.2: Summary of measured viscosities from capillary measurement. Oil/

  20. High-Throughput Computational Screening of thermal conductivity, Debye temperature and Gruneisen parameter

    E-Print Network [OSTI]

    Curtarolo, Stefano

    , such us the development of new thermoelectric materials1,2 , heat sink materials for ther- mal management and Materials Science, Duke University, Durham, North Carolina 27708, USA 2 Department of Materials Science Department of Physics and Department of Chemistry, University of North Texas, Denton TX 4 Materials Science

  1. High-throughput Isolation and Characterization of Untagged Membrane Protein Complexes: Outer Membrane Complexes

    E-Print Network [OSTI]

    , Evelin D. Szakal,§, Haichuan Liu,§ Steven C. Hall,§ Susan J. Fisher,,§ Bonita R. Lam, Mary E. Singer, Jil

  2. High-throughput multispot single-molecule spectroscopy Ryan A. Colyera*

    E-Print Network [OSTI]

    Michalet, Xavier

    an approach to multiple spot generation which is flexible, user-friendly, and rapidly adjustable so-spot generation methods, such as the use of microlens arrays with a static configuration 3 , 2D fiber arrays (e on silicon (LCOS) devices with computationally complex pattern generation 4, 5 . However, we desire

  3. Estimating enrichment of repetitive elements from high-throughput sequence data

    E-Print Network [OSTI]

    Luquette, Lovelace J.

    We describe computational methods for analysis of repetitive elements from short-read sequencing data, and apply them to study histone modifications associated with the repetitive elements in human and mouse cells. Our ...

  4. High-Throughput/Combinatorial Techniques in Hydrogen Storage Materials R&D

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page onYouTube YouTube Note: Since the.pdfBreaking of Blythe Solar PowerCommercial Cold Climate HeatEnergy| Department of

  5. Attendees list from the U.S. Department of Energy's High Throughput

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The FutureComments from TarasaName Affiliation Ahern, Michael WorcesterScreening

  6. Agenda from the U.S. Department of Energy's High Throughput Screening of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't Your Destiny: The Future of1Albuquerque, NM - Building America TopAgenda - DOE TribalHydrogen

  7. High-Throughput/Combinatorial Techniques in Hydrogen Storage Materials R&D

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport(Fact Sheet), GeothermalGridHYDROGEND D e e p p a a rDepartment ofofa(presentation)

  8. Tools for Authentication

    SciTech Connect (OSTI)

    White, G

    2008-07-09T23:59:59.000Z

    Many recent Non-proliferation and Arms Control software projects include a software authentication component. In this context, 'authentication' is defined as determining that a software package performs only its intended purpose and performs that purpose correctly and reliably over many years. In addition to visual inspection by knowledgeable computer scientists, automated tools are needed to highlight suspicious code constructs both to aid the visual inspection and to guide program development. While many commercial tools are available for portions of the authentication task, they are proprietary, and have limited extensibility. An open-source, extensible tool can be customized to the unique needs of each project (projects can have both common and custom rules to detect flaws and security holes). Any such extensible tool must be based on a complete language compiler infrastructure, that is, one that can parse and digest the full language through its standard grammar. ROSE is precisely such a compiler infrastructure developed within DOE. ROSE is a robust source-to-source analysis and optimization infrastructure currently addressing large, million-line DOE applications in C, C++, and FORTRAN. This year, it has been extended to support the automated analysis of binaries. We continue to extend ROSE to address a number of security-specific requirements and apply it to software authentication for Non-proliferation and Arms Control projects. We will give an update on the status of our work.

  9. Electrically powered hand tool

    DOE Patents [OSTI]

    Myers, Kurt S.; Reed, Teddy R.

    2007-01-16T23:59:59.000Z

    An electrically powered hand tool is described and which includes a three phase electrical motor having a plurality of poles; an electrical motor drive electrically coupled with the three phase electrical motor; and a source of electrical power which is converted to greater than about 208 volts three-phase and which is electrically coupled with the electrical motor drive.

  10. Smart tool holder

    DOE Patents [OSTI]

    Day, R.D.; Foreman, L.R.; Hatch, D.J.; Meadows, M.S.

    1998-09-08T23:59:59.000Z

    There is provided an apparatus for machining surfaces to accuracies within the nanometer range by use of electrical current flow through the contact of the cutting tool with the workpiece as a feedback signal to control depth of cut. 3 figs.

  11. A novel polymeric microelectrode array for highly parallel, long-term neuronal culture and stimulation

    E-Print Network [OSTI]

    Talei Franzesi, Giovanni

    2008-01-01T23:59:59.000Z

    Cell-based high-throughput screening is emerging as a disruptive technology in drug discovery; however, massively parallel electrical assaying of neurons and cardiomyocites has until now been prohibitively expensive. To ...

  12. Performance evaluation of bound diamond ring tools

    SciTech Connect (OSTI)

    Piscotty, M.A.; Taylor, J.S.; Blaedel, K.L.

    1995-07-14T23:59:59.000Z

    LLNL is collaborating with the Center for Optics Manufacturing (COM) and the American Precision Optics Manufacturers Association (APOMA) to optimize bound diamond ring tools for the spherical generation of high quality optical surfaces. An important element of this work is establishing an experimentally-verified link between tooling properties and workpiece quality indicators such as roughness, subsurface damage and removal rate. In this paper, we report on a standardized methodology for assessing ring tool performance and its preliminary application to a set of commercially-available wheels. Our goals are to (1) assist optics manufacturers (users of the ring tools) in evaluating tools and in assessing their applicability for a given operation, and (2) provide performance feedback to wheel manufacturers to help optimize tooling for the optics industry. Our paper includes measurements of wheel performance for three 2-4 micron diamond bronze-bond wheels that were supplied by different manufacturers to nominally- identical specifications. Preliminary data suggests that the difference in performance levels among the wheels were small.

  13. Fluid blade disablement tool

    DOE Patents [OSTI]

    Jakaboski, Juan-Carlos (Albuquerque, NM); Hughs, Chance G. (Albuquerque, NM); Todd, Steven N. (Rio Rancho, NM)

    2012-01-10T23:59:59.000Z

    A fluid blade disablement (FBD) tool that forms both a focused fluid projectile that resembles a blade, which can provide precision penetration of a barrier wall, and a broad fluid projectile that functions substantially like a hammer, which can produce general disruption of structures behind the barrier wall. Embodiments of the FBD tool comprise a container capable of holding fluid, an explosive assembly which is positioned within the container and which comprises an explosive holder and explosive, and a means for detonating. The container has a concavity on the side adjacent to the exposed surface of the explosive. The position of the concavity relative to the explosive and its construction of materials with thicknesses that facilitate inversion and/or rupture of the concavity wall enable the formation of a sharp and coherent blade of fluid advancing ahead of the detonation gases.

  14. Pneumatic soil removal tool

    DOE Patents [OSTI]

    Neuhaus, J.E.

    1992-10-13T23:59:59.000Z

    A soil removal tool is provided for removing radioactive soil, rock and other debris from the bottom of an excavation, while permitting the operator to be located outside of a containment for that excavation. The tool includes a fixed jaw, secured to one end of an elongate pipe, which cooperates with a movable jaw pivotably mounted on the pipe. Movement of the movable jaw is controlled by a pneumatic cylinder mounted on the pipe. The actuator rod of the pneumatic cylinder is connected to a collar which is slidably mounted on the pipe and forms part of the pivotable mounting assembly for the movable jaw. Air is supplied to the pneumatic cylinder through a handle connected to the pipe, under the control of an actuator valve mounted on the handle, to provide movement of the movable jaw. 3 figs.

  15. Pneumatic soil removal tool

    DOE Patents [OSTI]

    Neuhaus, John E. (Newport News, VA)

    1992-01-01T23:59:59.000Z

    A soil removal tool is provided for removing radioactive soil, rock and other debris from the bottom of an excavation, while permitting the operator to be located outside of a containment for that excavation. The tool includes a fixed jaw, secured to one end of an elongate pipe, which cooperates with a movable jaw pivotably mounted on the pipe. Movement of the movable jaw is controlled by a pneumatic cylinder mounted on the pipe. The actuator rod of the pneumatic cylinder is connected to a collar which is slidably mounted on the pipe and forms part of the pivotable mounting assembly for the movable jaw. Air is supplied to the pneumatic cylinder through a handle connected to the pipe, under the control of an actuator valve mounted on the handle, to provide movement of the movable jaw.

  16. Algal functional annotation tool

    SciTech Connect (OSTI)

    Lopez, D. [UCLA; Casero, D. [UCLA; Cokus, S. J. [UCLA; Merchant, S. S. [UCLA; Pellegrini, M. [UCLA

    2012-07-01T23:59:59.000Z

    The Algal Functional Annotation Tool is a web-based comprehensive analysis suite integrating annotation data from several pathway, ontology, and protein family databases. The current version provides annotation for the model alga Chlamydomonas reinhardtii, and in the future will include additional genomes. The site allows users to interpret large gene lists by identifying associated functional terms, and their enrichment. Additionally, expression data for several experimental conditions were compiled and analyzed to provide an expression-based enrichment search. A tool to search for functionally-related genes based on gene expression across these conditions is also provided. Other features include dynamic visualization of genes on KEGG pathway maps and batch gene identifier conversion.

  17. Java Vertexing Tools

    SciTech Connect (OSTI)

    Strube, Jan; /Oregon U.; Graf, Norman; /SLAC

    2006-03-03T23:59:59.000Z

    This document describes the implementation of the topological vertex finding algorithm ZVTOP within the org.lcsim reconstruction and analysis framework. At the present date, Java vertexing tools allow users to perform topological vertexing on tracks that have been obtained from a Fast MC simulation. An implementation that will be able to handle fully reconstructed events is being designed from the ground up for longevity and maintainability.

  18. Frequency Response Analysis Tool

    SciTech Connect (OSTI)

    Etingov, Pavel V.; Kosterev, Dmitry; Dai, T.

    2014-12-31T23:59:59.000Z

    Frequency response has received a lot of attention in recent years at the national level, which culminated in the development and approval of North American Electricity Reliability Corporation (NERC) BAL-003-1 Frequency Response and Frequency Bias Setting Reliability Standard. This report is prepared to describe the details of the work conducted by Pacific Northwest National Laboratory (PNNL) in collaboration with the Bonneville Power Administration and Western Electricity Coordinating Council (WECC) Joint Synchronized Information Subcommittee (JSIS) to develop a frequency response analysis tool (FRAT). The document provides the details on the methodology and main features of the FRAT. The tool manages the database of under-frequency events and calculates the frequency response baseline. Frequency response calculations are consistent with frequency response measure (FRM) in NERC BAL-003-1 for an interconnection and balancing authority. The FRAT can use both phasor measurement unit (PMU) data, where available, and supervisory control and data acquisition (SCADA) data. The tool is also capable of automatically generating NERC Frequency Response Survey (FRS) forms required by BAL-003-1 Standard.

  19. Dewarless Logging Tool - 1st Generation

    SciTech Connect (OSTI)

    HENFLING,JOSEPH A.; NORMANN,RANDY A.

    2000-08-01T23:59:59.000Z

    This report focuses on Sandia National Laboratories' effort to create high-temperature logging tools for geothermal applications without the need for heat shielding. One of the mechanisms for failure in conventional downhole tools is temperature. They can only survive a limited number of hours in high temperature environments. For the first time since the evolution of integrated circuits, components are now commercially available that are qualified to 225 C with many continuing to work up to 300 C. These components are primarily based on Silicon-On-Insulator (SOI) technology. Sandia has developed and tested a simple data logger based on this technology that operates up to 300 C with a few limiting components operating to only 250 C without thermal protection. An actual well log to 240 C without shielding is discussed. The first prototype high-temperature tool measures pressure and temperature using a wire-line for power and communication. The tool is based around the HT83C51 microcontroller. A brief discussion of the background and status of the High Temperature Instrumentation program at Sandia, objectives, data logger development, and future project plans are given.

  20. Increasing throughput of multiplexed electrical bus in pipe-lined architecture

    DOE Patents [OSTI]

    Asaad, Sameh; Brezzo, Bernard V; Kapur, Mohit

    2014-05-27T23:59:59.000Z

    Techniques are disclosed for increasing the throughput of a multiplexed electrical bus by exploiting available pipeline stages of a computer or other system. For example, a method for increasing a throughput of an electrical bus that connects at least two devices in a system comprises introducing at least one signal hold stage in a signal-receiving one of the two devices, such that a maximum frequency at which the two devices are operated is not limited by a number of cycles of an operating frequency of the electrical bus needed for a signal to propagate from a signal-transmitting one of the two devices to the signal-receiving one of the two devices. Preferably, the signal hold stage introduced in the signal-receiving one of the two devices is a pipeline stage re-allocated from the signal-transmitting one of the two devices.

  1. A simple packet retransmission strategy for throughput and delay enhancement on power line communication channels

    SciTech Connect (OSTI)

    Onunga, J.O. (Kenya Posts and Telecommunications Corp., Nairobi (Kenya)); Donaldson, R.W. (Univ. of British Columbia, Vancouver (Canada). Dept. of Electrical Engineering)

    1993-07-01T23:59:59.000Z

    A new, simple, and effective communication protocol is developed and evaluated for use on power line distribution networks. The protocol involves retransmission of unacknowledged packets, which are sent in either single or multiple (N) copies in accordance with estimates of communication link quality. Multiple packet copies can be code combined at the receiver, using majority voting on each bit position, to reduce packet error rates. Adaptive link quality estimates are based on the receipt or absence of positive acknowledgements. Information throughput efficiency is calculated and N optimized in terms of system variables. Performance benefits of code combining are clearly demonstrated. The algorithm was implemented and tested using a five-station intrabuilding power line communications network operating at 1.2, 2.4, 4.8 and 9.6 kbit/s data rate. Substantial throughput and delay improvement occurred on poor quality links, without degrading performance on good links.

  2. A Review of High Occupancy Vehicle (HOV) Lane Performance and...

    Open Energy Info (EERE)

    High Occupancy Vehicle (HOV) Lane Performance and Policy Options in the United States: Final Report Jump to: navigation, search Tool Summary LAUNCH TOOL Name: A Review of High...

  3. Development Tools at NERSC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625govInstrumentstdmadapInactiveVisitingContract Management FermiDavid Turner David3DepthDetectingNERSC Helps3Tools

  4. 5, 12291261, 2012 diagnostic tool

    E-Print Network [OSTI]

    Gettelman, Andrew

    GMDD 5, 1229­1261, 2012 Community diagnostic tool A. Gettelman et al. Title Page Abstract to the corresponding final paper in GMD if available. A community diagnostic tool for Chemistry Climate Model Community diagnostic tool A. Gettelman et al. Title Page Abstract Introduction Conclusions References Tables

  5. Command Line Tools Cloud Computing

    E-Print Network [OSTI]

    Ferrara, Katherine W.

    Command Line Tools Cloud Computing #12;Everybody (or nearly everybody) loves GUI. AWS Command Line of advanced features. After surviving the cloud computing class till now, Your are almost a command line guru! You need AWS command line tools, ec2-api-tools, to maximize the power of AWS cloud computing. Plugging

  6. BEAM EMITTANCE MEASUREMENT TOOL FOR CEBAF OPERATIONS

    SciTech Connect (OSTI)

    Chevtsov, Pavel; Tiefenback, Michael

    2008-10-01T23:59:59.000Z

    A new software tool was created at Jefferson Lab to measure the emittance of the CEBAF electron beams. The tool consists of device control and data analysis applications. The device control application handles the work of wire scanners and writes their measurement results as well as the information about accelerator settings during these measurements into wire scanner data files. The data analysis application reads these files and calculates the beam emittance on the basis of a wire scanner data processing model. Both applications are computer platform independent but are mostly used on LINUX PCs recently installed in the accelerator control room. The new tool significantly simplifies beam emittance measurement procedures for accelerator operations and contributes to a very high availability of the CEBAF machine for the nuclear physics program at Jefferson Lab.

  7. Butt Joint Tool Commissioning

    SciTech Connect (OSTI)

    Martovetsky, N N

    2007-12-06T23:59:59.000Z

    ITER Central Solenoid uses butt joints for connecting the pancakes in the CS module. The principles of the butt joining of the CICC were developed by the JAPT during CSMC project. The difference between the CSMC butt joint and the CS butt joint is that the CS butt joint is an in-line joint, while the CSMC is a double joint through a hairpin jumper. The CS butt joint has to carry the hoop load. The straight length of the joint is only 320 mm, and the vacuum chamber around the joint has to have a split in the clamp shell. These requirements are challenging. Fig.1 presents a CSMC joint, and Fig.2 shows a CS butt joint. The butt joint procedure was verified and demonstrated. The tool is capable of achieving all specified parameters. The vacuum in the end was a little higher than the target, which is not critical and readily correctable. We consider, tentatively that the procedure is established. Unexpectedly, we discover significant temperature nonuniformity in the joint cross section, which is not formally a violation of the specs, but is a point of concern. All testing parameters are recorded for QA purposes. We plan to modify the butt joining tool to improve its convenience of operation and provide all features necessary for production of butt joints by qualified personnel.

  8. One of John Dempsey Hospital's new quality improvement tools

    E-Print Network [OSTI]

    Oliver, Douglas L.

    One of John Dempsey Hospital's new quality improvement tools borrows lessons learned from the nuclear power industry, manufac turing and aviation. "Safety is a science. Reliability is a science, is a former Navy pilot. "We're learning specific tools based on high reliability tech niques to improve

  9. Downhole tool adapted for telemetry

    DOE Patents [OSTI]

    Hall, David R. (Provo, UT); Fox, Joe (Provo, UT)

    2010-12-14T23:59:59.000Z

    A cycleable downhole tool such as a Jar, a hydraulic hammer, and a shock absorber adapted for telemetry. This invention applies to other tools where the active components of the tool are displaced when the tool is rotationally or translationally cycled. The invention consists of inductive or contact transmission rings that are connected by an extensible conductor. The extensible conductor permits the transmission of the signal before, after, and during the cycling of the tool. The signal may be continuous or intermittent during cycling. The invention also applies to downhole tools that do not cycle, but in operation are under such stress that an extensible conductor is beneficial. The extensible conductor may also consist of an extensible portion and a fixed portion. The extensible conductor also features clamps that maintain the conductor under stresses greater than that seen by the tool, and seals that are capable of protecting against downhole pressure and contamination.

  10. Summary Xylem vulnerability to cavitation is a promising criterion for identifying trees with high drought tolerance, but

    E-Print Network [OSTI]

    Mencuccini, Maurizio

    Summary Xylem vulnerability to cavitation is a promising criterion for identifying trees with high drought tolerance, but traditional techniques for measuring cavitation resistance are unsuitablefor throughput screening of cavitation resistance in five poplar (Populus spp.) andfour willow (Salix spp

  11. Electronic authoring tools

    SciTech Connect (OSTI)

    Hurford, J.M.

    1987-01-01T23:59:59.000Z

    More than a decade ago, word processing software revolutionized the way documents were prepared, and productivity was increased. But the editing and formatting capabilities of most word processors did very little to prevent errors in spelling, typing, grammar, diction, style, or organization from slipping through to the final documents. In the past few years, the number of software tools that aid the author has increased substantially. They now vary in scope from simple spelling checkers to sophisticated diction analyzers and idea processors. Moreover, writing-aid-software described in this report is now available for many types of computing systems, including personal computers, scientific workstations, and mainframes. The various pieces of software can be used in interactive or non-interactive (batch) modes.

  12. Steam System Tool Suite Introduction Guide

    E-Print Network [OSTI]

    Oak Ridge National Laboratory

    Steam System Tool Suite Introduction Guide Alternate Text Narratives and Graphic.............................................................................................................................6 Modules Steam System Scoping Tool (SSST)........................................................................................8 Steam System Assessment Tool (SSAT

  13. Sandia Energy - Smart Grid Tools and Technology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Smart Grid Tools and Technology Home Stationary Power Grid Modernization Renewable Energy Integration Smart Grid Tools and Technology Smart Grid Tools and TechnologyTara...

  14. Supporting integrated design through interlinked tools: The Labs21 toolkit

    SciTech Connect (OSTI)

    Mathew, Paul; Bell, Geoffrey; Carlisle, Nancy; Sartor, Dale; van Geet, Otto; Lintner, William; Wirdzek, Phil

    2003-09-15T23:59:59.000Z

    The sustainable design of complex building types such as laboratories and hospitals can be particularly challenging, given their inherent complexity of systems, health and safety requirements, long-term flexibility and adaptability needs, energy use intensity, and environmental impacts. Tools such as design guides, energy benchmarking, and LEED rating systems are especially helpful to support sustainable design in such buildings. Furthermore, designers need guidance on how to effectively and appropriately use each tool within the context of an integrated design process involving multiple actors with various objectives. Toward this end, the Laboratories for the 21st Century (Labs21) program has developed an interlinked set of tools -- the Labs21 Toolkit -- to support an integrated design process for sustainable laboratories. Labs21 is a voluntary partnership program sponsored by the U.S. Environmental Protection Agency (EPA) and U.S. Department of Energy (DOE) to improve the environment al performance of U.S. laboratories. In this paper, we present the Labs21 Toolkit, and illustrate how these tools can be used to support sustainable design within an integrated design process. The tool kit includes core information tools, as well as process-related tools, as indicated below: Core information tools: -A Design Guide, which is a compendium of publications on energy efficiency in laboratories -Case Studies that showcase high-performance design features and applications. -Best Practice Guides that highlight industry-leading sustainable design strategies. -A web-based Benchmarking Tool to benchmark laboratory energy performance.Process tools: -A Design Intent Tool, which can be used to used to plan, document, and verify that a facility's design intent is being met at each stage of the design process. The Environmental Performance Criteria (EPC), a rating system specifically designed for laboratory facilities that builds on the LEED(TM) system. -A web-based Process Manual, that provides a ''portal'' to the tools and a step-by-step process for using these tools during each stage of the design process.

  15. Survey of Existing Tools for Formal Verification.

    SciTech Connect (OSTI)

    Punnoose, Ratish J.; Armstrong, Robert C.; Wong, Matthew H.; Jackson, Mayo

    2014-12-01T23:59:59.000Z

    Formal methods have come into wide use because of their effectiveness in verifying %22safety and security%22 requirements of digital systems; a set of requirements for which testing is mostly ineffective. Formal methods are routinely used in the design and verification of high-consequence digital systems in industry. This report outlines our work in assessing the capabilities of commercial and open source formal tools and the ways in which they can be leveraged in digital design workflows.

  16. Automated energy monitoring of machine tools

    E-Print Network [OSTI]

    Vijayaraghavan, Athulan; Dornfeld, David

    2010-01-01T23:59:59.000Z

    in manufacturing the tooling for many consumer products,process parameters, tooling, and cutting ?uid based on

  17. Information Technology Tools for Multifamily Building Programs...

    Energy Savers [EERE]

    Information Technology Tools for Multifamily Building Programs Information Technology Tools for Multifamily Building Programs Better Buildings Neighborhood Program Multifamily ...

  18. Natural System Evaluation and Tool Development: International...

    Energy Savers [EERE]

    Natural System Evaluation and Tool Development: International Collaborations - FY'13 Progress Report Natural System Evaluation and Tool Development: International Collaborations -...

  19. Your UNIX Account Basic Unix Tools

    E-Print Network [OSTI]

    Qiu, Weigang

    Your UNIX Account 2 Basic Unix Tools 3 Unix Power Tools Weigang Qiu Introduction & UNIX Tutorial #12 & UNIX Tutorial #12;Your UNIX Account Basic Unix Tools Unix Power Tools UNIX Directory Structure FileYour UNIX Account Basic Unix Tools Unix Power Tools Introduction & UNIX Tutorial Weigang Qiu

  20. Security tasks are highly interdependent.

    E-Print Network [OSTI]

    Motivation Security tasks are highly interdependent. To improve security tools, we need to understand how security practitioners collaborate in their organizations. Security practitioners in context Exchange of Information Develop security tools that: · Integrate information from different communication