Sample records for high throughput tools

  1. High-Throughput, High-Precision Hot Testing Tool for High-Brightness...

    Energy Savers [EERE]

    Throughput, High-Precision Hot Testing Tool for High-Brightness Light-Emitting Diode Testing High-Throughput, High-Precision Hot Testing Tool for High-Brightness Light-Emitting...

  2. New Tools for High Throughput Chemistry and Biology

    E-Print Network [OSTI]

    Galveia, Luciano Paulo Rosa

    2011-01-01T23:59:59.000Z

    New strategies for the high-throughput determination of protease substrate specificity using a dual colour microarray based format with a small library of FRET-based peptides were developed. Integral to this process was ...

  3. ORIGINAL ARTICLE GeoChip 3.0 as a high-throughput tool for analyzing

    E-Print Network [OSTI]

    Hazen, Terry

    significantly changed with the plant species diversity. As expected, GeoChip 3.0 is a high-throughput powerful Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA and 8 Virtual Institute Keywords: microarray; functional genes; microbial community; plant diversity Introduction Microorganisms

  4. ORIGINAL ARTICLE GeoChip 3.0 as a high-throughput tool for analyzing

    E-Print Network [OSTI]

    Weiblen, George D

    significantly changed with the plant species diversity. As expected, GeoChip 3.0 is a high-throughput powerful Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA and 8 Virtual Institute in microbial ecology Keywords: microarray; functional genes; microbial community; plant diversity Introduction

  5. High throughput optical scanner

    DOE Patents [OSTI]

    Basiji, David A. (Seattle, WA); van den Engh, Gerrit J. (Seattle, WA)

    2001-01-01T23:59:59.000Z

    A scanning apparatus is provided to obtain automated, rapid and sensitive scanning of substrate fluorescence, optical density or phosphorescence. The scanner uses a constant path length optical train, which enables the combination of a moving beam for high speed scanning with phase-sensitive detection for noise reduction, comprising a light source, a scanning mirror to receive light from the light source and sweep it across a steering mirror, a steering mirror to receive light from the scanning mirror and reflect it to the substrate, whereby it is swept across the substrate along a scan arc, and a photodetector to receive emitted or scattered light from the substrate, wherein the optical path length from the light source to the photodetector is substantially constant throughout the sweep across the substrate. The optical train can further include a waveguide or mirror to collect emitted or scattered light from the substrate and direct it to the photodetector. For phase-sensitive detection the light source is intensity modulated and the detector is connected to phase-sensitive detection electronics. A scanner using a substrate translator is also provided. For two dimensional imaging the substrate is translated in one dimension while the scanning mirror scans the beam in a second dimension. For a high throughput scanner, stacks of substrates are loaded onto a conveyor belt from a tray feeder.

  6. Development and optimization of high-throughput zebrafish screening platform

    E-Print Network [OSTI]

    Koo, Bryan Kyo

    2010-01-01T23:59:59.000Z

    The high-throughput zebrafish screening platform is a revolutionary tool that enables subcellular precision in vivo whole animal screening of Danio Rerio. It can perform laser surgery and/or imaging in less than twenty ...

  7. High throughput protein production screening

    DOE Patents [OSTI]

    Beernink, Peter T. (Walnut Creek, CA); Coleman, Matthew A. (Oakland, CA); Segelke, Brent W. (San Ramon, CA)

    2009-09-08T23:59:59.000Z

    Methods, compositions, and kits for the cell-free production and analysis of proteins are provided. The invention allows for the production of proteins from prokaryotic sequences or eukaryotic sequences, including human cDNAs using PCR and IVT methods and detecting the proteins through fluorescence or immunoblot techniques. This invention can be used to identify optimized PCR and WT conditions, codon usages and mutations. The methods are readily automated and can be used for high throughput analysis of protein expression levels, interactions, and functional states.

  8. High-Throughput/Combinatorial Techniques in Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D (presentation) High-ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D (presentation)...

  9. High Throughput/Combinatorial Screening of Hydrogen Storage Materials...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials: UOP Approaches High ThroughputCombinatorial Screening of Hydrogen Storage Materials: UOP Approaches Presentation by Adriaan Sachtler from the High Throughput...

  10. High-Throughput and Combinatorial Screening of Hydrogen Storage...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High-Throughput and Combinatorial Screening of Hydrogen Storage Materials (presentation) High-Throughput and Combinatorial Screening of Hydrogen Storage Materials (presentation)...

  11. Potential of High-Throughput Experimentation with Ammonia Borane...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of High-Throughput Experimentation with Ammonia Borane Solid Hydrogen Storage Materials (presentation) Potential of High-Throughput Experimentation with Ammonia Borane Solid...

  12. High Throughput/Combinatorial Screening of Hydrogen Storage Materials...

    Broader source: Energy.gov (indexed) [DOE]

    UOP LLC. All rights reserved. High ThroughputCombinatorial Screening of Hydrogen Storage Materials: UOP Approaches High ThroughputCombinatorial Screening of Hydrogen Storage...

  13. High-throughput quantification of glycoprotein sialylation

    E-Print Network [OSTI]

    Markely, Lam Raga Anggara

    2011-01-01T23:59:59.000Z

    Sialic acid can improve qualities of therapeutic glycoproteins, such as circulatory half-life, biological activity, and solubility. In production of therapeutic glycoproteins, a high-throughput method (HTM) is required for ...

  14. High Throughput Materials Characterization John M. Gregoire

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Paper for Establishing a User Facility for Synchrotron-based High Throughput Materials Characterization John M. Gregoire 1 , Matthew J. Kramer 2 , Apurva Mehta 3 1 Joint Center for...

  15. High Throughput Operando Studies using Fourier Transform Infrared...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Throughput Operando Studies using Fourier Transform Infrared Imaging and Raman Spectroscopy. High Throughput Operando Studies using Fourier Transform Infrared Imaging and Raman...

  16. 2011 DoD High Performance Computing Modernization Program Users Group Conference A Web-based High-Throughput Tool for Next-Generation Sequence Annotation

    E-Print Network [OSTI]

    320 2011 DoD High Performance Computing Modernization Program Users Group Conference A Web deployed on the Mana Linux cluster at the Maui High Performance Computing Center. The two components

  17. Cell bioprinting as a potential high-throughput method for fabricating cell-based biosensors (CBBs)

    E-Print Network [OSTI]

    Xu, F.

    Cell-based biosensors (CBBs) are becoming an important tool for biosecurity applications and rapid diagnostics. For current CBBs technology, cell immobilization and high throughput fabrication are the main challenges. To ...

  18. High throughput chemical munitions treatment system

    DOE Patents [OSTI]

    Haroldsen, Brent L. (Manteca, CA); Stofleth, Jerome H. (Albuquerque, NM); Didlake, Jr., John E. (Livermore, CA); Wu, Benjamin C-P (San Ramon, CA)

    2011-11-01T23:59:59.000Z

    A new High-Throughput Explosive Destruction System is disclosed. The new system is comprised of two side-by-side detonation containment vessels each comprising first and second halves that feed into a single agent treatment vessel. Both detonation containment vessels further comprise a surrounding ventilation facility. Moreover, the detonation containment vessels are designed to separate into two half-shells, wherein one shell can be moved axially away from the fixed, second half for ease of access and loading. The vessels are closed by means of a surrounding, clam-shell type locking seal mechanisms.

  19. High Throughput Combinatorial Screening of Biometic Metal-Organic...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    High Throughput Combinatorial Screening of Biometic Metal-Organic Materials for Military Hydrogen-Storage Materials (New Joint Miami UNREL DoDDLA Project) (presentation) High...

  20. High Throughput/Combinatorial Screening of Hydrogen Storage Materials...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials (presentation) High ThroughputCombinatorial Screening of Hydrogen Storage Materials (presentation) Presented at the U.S. Department of Energy's Hydrogen Storage Meeting...

  1. High Throughput/Combinatorial Screening of Hydrogen Storage Materials...

    Broader source: Energy.gov (indexed) [DOE]

    technologies and software to increase R&D efficiency in chemical, energy, electronics, pharmaceutical and academic labs. * Pioneer of High Throughput Research (HTR) for...

  2. ORIGINAL ARTICLE Combining high-throughput sequencing with fruit

    E-Print Network [OSTI]

    Bruns, Tom

    ORIGINAL ARTICLE Combining high-throughput sequencing with fruit body surveys reveals contrasting communities were mostly confined to fruit bodies, whereas mycelial interactions were studied in the laboratory. Here we combine high-throughput sequencing with a fruit body inventory to study simultaneously mycelial

  3. Microfluidic Technologies for High-Throughput Screening Applications

    E-Print Network [OSTI]

    Quake, Stephen R.

    Microfluidic Technologies for High-Throughput Screening Applications Thesis by Todd Thorsen, patiently giving me advice on a large variety of subjects, ranging from microfluidics to optics of microfluidic devices for high-throughput screening applications, such as mutant enzyme libraries expressed

  4. Netest: A Tool to Measure the Maximum Burst Size, Available Bandwidth and Achievable Throughput

    SciTech Connect (OSTI)

    Jin, Guojun; Tierney, Brian

    2003-01-31T23:59:59.000Z

    Distinguishing available bandwidth and achievable throughput is essential for improving network applications' performance. Achievable throughput is the throughput considering a number of factors such as network protocol, host speed, network path, and TCP buffer space, where as available bandwidth only considers the network path. Without understanding this difference, trying to improve network applications' performance is like ''blind men feeling the elephant'' [4]. In this paper, we define and distinguish bandwidth and throughput, and debate which part of each is achievable and which is available. Also, we introduce and discuss a new concept - Maximum Burst Size that is crucial to the network performance and bandwidth sharing. A tool, netest, is introduced to help users to determine the available bandwidth, and provides information to achieve better throughput with fairness of sharing the available bandwidth, thus reducing misuse of the network.

  5. High-Throughput/Combinatorial Techniques in Hydrogen Storage...

    Broader source: Energy.gov (indexed) [DOE]

    Storage (New DoDDLA Project), Ali T-Raissi, University of Central Florida, Florida Solar Energy Center High-Throughput Methodology for Discovery of Metal-Organic Frameworks...

  6. Temperature response of the ultra-high throughput mutational spectrometer

    E-Print Network [OSTI]

    Suen, Timothy W. (Timothy Wu)

    2005-01-01T23:59:59.000Z

    The Ultra-High Throughput Mutational Spectrometer is an instrument designed to separate mutant from wild type DNA through capillary electrophoresis. Since this technique uses the melting point of the molecule to distinguish ...

  7. High throughput optical sensor arrays for drug screening

    E-Print Network [OSTI]

    Harjes, Daniel I

    2006-01-01T23:59:59.000Z

    In the world of drug discovery, high throughput whole cell assays are a critical step in discovering therapeutically relevant drug compounds [1]. This report details the development of several novel sensor systems capable ...

  8. High-throughput vertebrate total analysis/screening platform

    E-Print Network [OSTI]

    Chang, Tsung-Yao, Ph. D. Massachusetts Institute of Technology

    2012-01-01T23:59:59.000Z

    High-throughput screening (HTS) is seen as one of the most promising technologies to facilitate biomedical studies and pharmaceutical discoveries. Although large varieties of in vitro HTS technologies have opened great ...

  9. High throughput lessons from the LHC experience.Johnston.TNC2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    both ends (typically a GPS- based clock, or comparable). These tools are OWAMP 22 and HADES 23. Throughput is measured with BWCTL (a wrapper and controller for iperf throughput...

  10. Approaches to High Throughput Physical Organic Chemistry

    E-Print Network [OSTI]

    Portal, Christophe

    2008-01-01T23:59:59.000Z

    compounds, using positive electrospray MS as the sole analytical tool. A version of the construct allowed HT reactivity profiling to be carried out on a range of ten carboxylic acids, ten aldehydes and ten isonitriles in the Ugi 4-component condensation...

  11. Research Focus High-throughput screens for fluorescent dye discovery

    E-Print Network [OSTI]

    Carpenter, Anne E.

    Research Focus High-throughput screens for fluorescent dye discovery Vebjorn Ljosa and Anne E of a combinatorial library of fluorescent compounds discovered fluorescent dyes that were able to distinguish myoblasts from differentiated myotubes. New fluorescent dyes that respond to biologically relevant changes

  12. High Throughput Spectrum-aware Routing for Cognitive Radio Networks

    E-Print Network [OSTI]

    Zhao, Ben Y.

    High Throughput Spectrum-aware Routing for Cognitive Radio Networks Ashwin Sampath, Lei Yang, Lili, wireless nodes equipped with cognitive radios [11] do not operate on statically as- signed spectrum who own the spectrum, e.g. analog TV broadcast stations. Such flexibility means cognitive radios can

  13. High Throughput Spectrumaware Routing for Cognitive Radio Networks

    E-Print Network [OSTI]

    Zhao, Ben Y.

    High Throughput Spectrum­aware Routing for Cognitive Radio Networks Ashwin Sampath, Lei Yang, Lili, wireless nodes equipped with cognitive radios [11] do not operate on statically as­ signed spectrum. Instead, they identify and use locally unused licensed spectrum while avoiding disruptions to legacy users

  14. High Throughput Materials Characterization John M. Gregoire

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickr FlickrGuidedCH2M HILLAdministrationHigh SchoolHigh

  15. Agenda from the U.S. Department of Energy's High Throughput Screening...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    from the U.S. Department of Energy's High Throughput Screening of Hydrogen Storage Materials Workshop on June 26, 2007 Agenda from the U.S. Department of Energy's High Throughput...

  16. Engineering of a High-Throughput Screening System to Identify Cellulosic Biomass,

    E-Print Network [OSTI]

    California at Riverside, University of

    - grated high-throughput (HTP) screening pipeline. Herein, we report on the engineering of a novel HTP

  17. PIPA: A High-Throughput Pipeline for Protein Function Annotation Chenggang Yu, Valmik Desai, Nela Zavaljevski, and Jaques Reifman

    E-Print Network [OSTI]

    PIPA: A High-Throughput Pipeline for Protein Function Annotation Chenggang Yu, Valmik Desai, Nela of multisource predictions. We developed Pipeline for Protein Annotation (PIPA), a genome-wide protein function annotation pipeline that runs in a high-performance computing environment. PIPA integrates different tools

  18. Methods and technologies for high-throughput and high-content small animal screening

    E-Print Network [OSTI]

    Rohde, Christopher, 1979-

    2012-01-01T23:59:59.000Z

    High-throughput and high-content screening (HTS and HCS) of whole animals requires their immobilization for high-resolution imaging and manipulation. Here we present methods to enable HTS and HCS of the nematode Caenorhabditis ...

  19. Grid Workflow Software for a High-Throughput Proteome Annotation Pipeline

    E-Print Network [OSTI]

    Bourne, Philip E.

    Grid Workflow Software for a High-Throughput Proteome Annotation Pipeline Adam Birnbaum1 , James-Throughput Proteome 69 Protein Data Bank [9]. Despite the advent of high throughput crystallization pipelines [25 Annotation Pipeline (iGAP) [28]. iGAP, which incorporates a number of well established bioinformatics

  20. Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

    E-Print Network [OSTI]

    Wu, Zhigang

    2009-01-01T23:59:59.000Z

    Soft inertial microfluidics for high throughput separation1 Introduction Microfluidics has gained significant advancesof mammalian cells using microfluidics 3,4 , there have been

  1. automating high-throughput blast: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to electron transfer dissoci- ation (ETD) mass spectrometry Shorter, James 15 Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium...

  2. Inch-Scale High Throughput Metrology of Graphene and Patterned Graphene Oxide.

    E-Print Network [OSTI]

    Pleskot, Dennis

    2013-01-01T23:59:59.000Z

    ??Abstract Inch-Scale High Throughput Metrology of Graphene and Patterned Graphene Oxide by Dennis Pleskot Master of Science, Graduate Program in Materials Science and Engineering University (more)

  3. A microfluidic platform for high-throughput multiplexed protein quantitation

    E-Print Network [OSTI]

    Volpetti, Francesca; Maerkl, Sebastian

    2014-01-01T23:59:59.000Z

    We present a high-throughput microfluidic platform capable of quantitating up to 384 biomarkers in 4 distinct samples by immunoassay. The microfluidic device contains 384 unit cells, which can be individually programmed with pairs of capture and detection antibody. Samples are quantitated in each unit cell by four independent MITOMI detection areas, allowing four samples to be analyzed in parallel for a total of 1,536 assays per device. We show that the device can be pre-assembled and stored for weeks at elevated temperature and we performed proof-of-concept experiments simultaneously quantitating IL-6, IL-1\\b{eta}, TNF-{\\alpha}, PSA, and GFP. Finally, we show that the platform can be used to identify functional antibody combinations by screening 64 antibody combinations requiring up to 384 unique assays per device.

  4. Generalized schemes for high throughput manipulation of the Desulfovibrio vulgaris Hildenborough genome

    SciTech Connect (OSTI)

    Chhabra, S.R.; Butland, G.; Elias, D.; Chandonia, J.-M.; Fok, V.; Juba, T.; Gorur, A.; Allen, S.; Leung, C.-M.; Keller, K.; Reveco, S.; Zane, G.; Semkiw, E.; Prathapam, R.; Gold, B.; Singer, M.; Ouellet, M.; Sazakal, E.; Jorgens, D.; Price, M.; Witkowska, E.; Beller, H.; Hazen, T.C.; Biggin, M.; Auer, M.; Wall, J.; Keasling, J.

    2011-07-15T23:59:59.000Z

    The ability to conduct advanced functional genomic studies of the thousands of sequenced bacteria has been hampered by the lack of available tools for making high- throughput chromosomal manipulations in a systematic manner that can be applied across diverse species. In this work, we highlight the use of synthetic biological tools to assemble custom suicide vectors with reusable and interchangeable DNA parts to facilitate chromosomal modification at designated loci. These constructs enable an array of downstream applications including gene replacement and creation of gene fusions with affinity purification or localization tags. We employed this approach to engineer chromosomal modifications in a bacterium that has previously proven difficult to manipulate genetically, Desulfovibrio vulgaris Hildenborough, to generate a library of over 700 strains. Furthermore, we demonstrate how these modifications can be used for examining metabolic pathways, protein-protein interactions, and protein localization. The ubiquity of suicide constructs in gene replacement throughout biology suggests that this approach can be applied to engineer a broad range of species for a diverse array of systems biological applications and is amenable to high-throughput implementation.

  5. HIGH-THROUGHPUT/COMBINATORIAL TECHNIQUES IN HYDROGEN STORAGE MATERIALS R&D WORKSHOP

    E-Print Network [OSTI]

    HIGH-THROUGHPUT/COMBINATORIAL TECHNIQUES IN HYDROGEN STORAGE MATERIALS R&D WORKSHOP U.S. Department 26, 2007, DOE's Hydrogen Storage Program held a one-day High- Throughput/Combinatorial Techniques in Hydrogen Storage Materials R&D meeting to identify how to better implement high

  6. High throughput energy efficient multi-FFT architecture on FPGAs (Draft)

    E-Print Network [OSTI]

    Prasanna, Viktor K.

    computing, High throughput FFT, Energy efficient design I. INTRODUCTION As FPGAs are programmed specifically in spread spec- trum receiver [4]. In the design of high throughput FFT architectures, energy-efficient design techniques can be used to maximize performance under power dissipation constraints. The power

  7. High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation

    E-Print Network [OSTI]

    Zandstra, Peter W.

    High-throughput generation of hydrogel microbeads with varying elasticity for cell encapsulation a microfluidic approach for high-throughput generation of 3D microenvironments with different elasticity for studies of cell fate. The generation of agarose microgels with different elastic moduli was achieved by (i

  8. High-throughput metal nanoparticle catalysis by pulsed laser ablation Selim Senkan a,*, Michael Kahn a

    E-Print Network [OSTI]

    Senkan, Selim M.

    High-throughput metal nanoparticle catalysis by pulsed laser ablation Selim Senkan a,*, Michael online 18 July 2006 Abstract A high-throughput pulsed laser ablation (HT-PLA) system was developed-TEM) and energy dispersive X-ray (EDX) spectroscopy, respectively. The supported nanoparticles created by HT

  9. Parallel Interleaver Architecture with New Scheduling Scheme for High Throughput Configurable Turbo Decoder

    E-Print Network [OSTI]

    Mellor-Crummey, John

    Parallel Interleaver Architecture with New Scheduling Scheme for High Throughput Configurable Turbo}@rice.edu, yuanbinguo@huawei.com Abstract--Parallel architecture is required for high throughput turbo decoder to meet also shows great flexibility and scalability compared to prior work. Index Terms--VLSI, turbo decoder

  10. CONTINUOUS ROLL-TO-ROLL SERPENTINE DEPOSITION FOR HIGH THROUGHPUT a-Si PV MANUFACTURING

    E-Print Network [OSTI]

    Deng, Xunming

    a number of advantages in a fully automated high throughput PV module production plant [l-18--a significant problem in many glass substrate amorphous silicon alloy PV module manufacturing plants. ECDCONTINUOUS ROLL-TO-ROLL SERPENTINE DEPOSITION FOR HIGH THROUGHPUT a-Si PV MANUFACTURING M. Izu, H

  11. High-Throughput/Combinatorial Techniques in Hydrogen Storage...

    Broader source: Energy.gov (indexed) [DOE]

    ThroughputCombinatorial Techniques in Hydrogen Storage Materials R&D Ned Stetson, Larry Blair 1 , Grace Ordaz, Carole Read, George Thomas 2 , and Sunita Satyapal Suite 900, 7475...

  12. FastForward: High-Throughput Dual-Radio Streaming Gholamhossein Ekbatanifard

    E-Print Network [OSTI]

    Kuzmanov, Georgi

    amount of data at high throughput and/or low latency. For example, structural health of the Golden Gate end-to-end throughput is limited to 1/2 the radio capacity. To bridge this performance gap we present Bridge was sampled at 1 KHz in [1]. Brimon, a railway monitoring system, generates about 7 KB in each

  13. High-throughput analysis of thin-film stresses using arrays of micromachined cantilever beams

    E-Print Network [OSTI]

    High-throughput analysis of thin-film stresses using arrays of micromachined cantilever beams Hyun-throughput residual stress measurements on thin films by means of micromachined cantilever beams and an array of parallel laser beams. In this technique, the film of interest is deposited onto a silicon substrate

  14. Determination of Monomethylhydrazine with a High-Throughput, All-Fiber Near-Infrared

    E-Print Network [OSTI]

    Reid, Scott A.

    Determination of Monomethylhydrazine with a High-Throughput, All-Fiber Near-Infrared Spectrometer-throughput near-infrared spectrophotometer has been successfully constructed by synergistic use of this integrated and wide spectral band- width in the near-infrared region from 1500 to 1600 nm. This spectral region

  15. Advances in High Throughput Screening of Biomass Recalcitrance (Poster)

    SciTech Connect (OSTI)

    Turner, G. B.; Decker, S. R.; Tucker, M. P.; Law, C.; Doeppke, C.; Sykes, R. W.; Davis, M. F.; Ziebell, A.

    2012-06-01T23:59:59.000Z

    This was a poster displayed at the Symposium. Advances on previous high throughput screening of biomass recalcitrance methods have resulted in improved conversion and replicate precision. Changes in plate reactor metallurgy, improved preparation of control biomass, species-specific pretreatment conditions, and enzymatic hydrolysis parameters have reduced overall coefficients of variation to an average of 6% for sample replicates. These method changes have improved plate-to-plate variation of control biomass recalcitrance and improved confidence in sugar release differences between samples. With smaller errors plant researchers can have a higher degree of assurance more low recalcitrance candidates can be identified. Significant changes in plate reactor, control biomass preparation, pretreatment conditions and enzyme have significantly reduced sample and control replicate variability. Reactor plate metallurgy significantly impacts sugar release aluminum leaching into reaction during pretreatment degrades sugars and inhibits enzyme activity. Removal of starch and extractives significantly decreases control biomass variability. New enzyme formulations give more consistent and higher conversion levels, however required re-optimization for switchgrass. Pretreatment time and temperature (severity) should be adjusted to specific biomass types i.e. woody vs. herbaceous. Desalting of enzyme preps to remove low molecular weight stabilizers and improved conversion levels likely due to water activity impacts on enzyme structure and substrate interactions not attempted here due to need to continually desalt and validate precise enzyme concentration and activity.

  16. E-Print Network 3.0 - alphascreen high-throughput assay Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Session Chair: James F. Leary 3:20-4:05 James F. Leary, "High throughput cell analysis... French and Jiyan Chen Long Lifetime Measurements in High ... Source: Xu, X. Nancy -...

  17. ENHANCED DOE HIGH LEVEL WASTE MELTER THROUGHPUT STUDIES: SRNL GLASS SELECTION STRATEGY

    SciTech Connect (OSTI)

    Raszewski, F; Tommy Edwards, T; David Peeler, D

    2008-01-23T23:59:59.000Z

    The Department of Energy has authorized a team of glass formulation and processing experts at the Savannah River National Laboratory (SRNL), the Pacific Northwest National Laboratory (PNNL), and the Vitreous State Laboratory (VSL) at Catholic University of America to develop a systematic approach to increase high level waste melter throughput (by increasing waste loading with minimal or positive impacts on melt rate). This task is aimed at proof-of-principle testing and the development of tools to improve waste loading and melt rate, which will lead to higher waste throughput. Four specific tasks have been proposed to meet these objectives (for details, see WSRC-STI-2007-00483): (1) Integration and Oversight, (2) Crystal Accumulation Modeling (led by PNNL)/Higher Waste Loading Glasses (led by SRNL), (3) Melt Rate Evaluation and Modeling, and (4) Melter Scale Demonstrations. Task 2, Crystal Accumulation Modeling/Higher Waste Loading Glasses is the focus of this report. The objective of this study is to provide supplemental data to support the possible use of alternative melter technologies and/or implementation of alternative process control models or strategies to target higher waste loadings (WLs) for the Defense Waste Processing Facility (DWPF)--ultimately leading to higher waste throughputs and a reduced mission life. The glass selection strategy discussed in this report was developed to gain insight into specific technical issues that could limit or compromise the ability of glass formulation efforts to target higher WLs for future sludge batches at the Savannah River Site (SRS). These technical issues include Al-dissolution, higher TiO{sub 2} limits and homogeneity issues for coupled-operations, Al{sub 2}O{sub 3} solubility, and nepheline formation. To address these technical issues, a test matrix of 28 glass compositions has been developed based on 5 different sludge projections for future processing. The glasses will be fabricated and characterized based on the protocols outlined in the SRNL Task and Quality Assurance (QA) plan.

  18. Low inlet gas velocity high throughput biomass gasifier

    DOE Patents [OSTI]

    Feldmann, Herman F. (Worthington, OH); Paisley, Mark A. (Upper Arlington, OH)

    1989-01-01T23:59:59.000Z

    The present invention discloses a novel method of operating a gasifier for production of fuel gas from carbonaceous fuels. The process disclosed enables operating in an entrained mode using inlet gas velocities of less than 7 feet per second, feedstock throughputs exceeding 4000 lbs/ft.sup.2 -hr, and pressures below 100 psia.

  19. A high throughput (>90%), large compensation range, single-prism femtosecond pulse compressor

    E-Print Network [OSTI]

    Kong, Lingjie

    2013-01-01T23:59:59.000Z

    We demonstrate a high throughput, large compensation range, single-prism femtosecond pulse compressor, using a single prism and two roof mirrors. The compressor has zero angular dispersion, zero spatial dispersion, zero pulse-front tilt, and unity magnification. The high efficiency is achieved by adopting two roof mirrors as the retroreflectors. We experimentally achieved ~ -14500 fs2 group delay dispersion (GDD) with 30 cm of prism tip-roof mirror prism separation, and ~90.7% system throughput with the current implementation. With better components, the throughput can be even higher.

  20. Attendees list from the U.S. Department of Energy's High Throughput...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Attendees list from the U.S. Department of Energy's High Throughput Screening of Hydrogen Storage Materials Workshop on June 26, 2007 Attendees list from the U.S. Department of...

  1. Molecular display of synthetic oligonucleotide libraries and their analysis with high throughput DNA sequencing

    E-Print Network [OSTI]

    Larman, Harry Benjamin

    2012-01-01T23:59:59.000Z

    High throughput methods in molecular biology have changed the landscape of biomedical research. In particular, advances in massively parallel DNA sequencing and synthesis technologies are defining our genomes and the ...

  2. An instrument for high-throughput measurements of fiber mechanical properties

    E-Print Network [OSTI]

    Kristofek, Grant William, 1980-

    2005-01-01T23:59:59.000Z

    In this thesis, an instrument is designed and constructed for the purpose of measuring the mechanical properties of single fibers. The instrument is intended to provide high throughput measurement of single fiber geometric ...

  3. Discovery and High-Throughput Screening of Heteroleptic Iridium Complexes for Photoinduced Hydrogen Production

    E-Print Network [OSTI]

    Bernhard, Stefan

    high-throughput photophysical techniques, to identify six potential photosensitizers for use researchers. Simple solar devices focus or collect sunlight, harnessing radiation in order to heat dwellings or drive turbines. Photovoltaic cells can convert solar radiation directly to electrical current

  4. The Materials genome : rapid materials screening for renewable energy using high-throughput density functional theory

    E-Print Network [OSTI]

    Jain, Anubhav, Ph.D. Massachusetts Institute of Technology

    2011-01-01T23:59:59.000Z

    This thesis relates to the emerging field of high-throughput density functional theory (DFT) computation for materials design and optimization. Although highthroughput DFT is a promising new method for materials discovery, ...

  5. Using High Throughput Screening to Acquire Promising Drug Candidates Against Mycobacterium tuberculosis

    E-Print Network [OSTI]

    LaiHing, Steven 1983-

    2011-07-27T23:59:59.000Z

    infection. High Throughput Screening can be used to both find and analyze promising drug candidates. Using automation, thousands of compounds can be tested against an attenuated strain of Tuberculosis and separate the promising compounds from the ineffective...

  6. Combined Catalysis and Optical Screening for High Throughput Discovery of Solar Fuels Catalysts

    E-Print Network [OSTI]

    Faraon, Andrei

    Combined Catalysis and Optical Screening for High Throughput Discovery of Solar Fuels Catalysts J,b a Joint Center for Artificial Photosynthesis, California Institute of Technology, Pasadena, California 91125, USA b Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720

  7. Development of High-Throughput Microfluidic Impedance Spectroscopy Platform for Analyzing Microdroplets in Droplet Microfluidic System

    E-Print Network [OSTI]

    Sobahi, Nebras MohammedKamal A.

    2014-07-22T23:59:59.000Z

    This thesis presents the development of a high-throughput microfluidic impedance spectroscopy platform for electrically detecting analyzing impedance measurements of non-contact and label free microdroplets. This microfluidic impedance spectroscopy...

  8. A microfluidic device for high throughput bacterial biofilm studies Jeongyun Kim,a

    E-Print Network [OSTI]

    Wood, Thomas K.

    A microfluidic device for high throughput bacterial biofilm studies Jeongyun Kim,a Manjunath Hegde of biofilm community formation. Here, we describe the development of a PDMS-based two-layer microfluidic flow

  9. Computational tools for high-throughput discovery in biology

    E-Print Network [OSTI]

    Jones, Neil Christopher

    2007-01-01T23:59:59.000Z

    approach of a Service Oriented Architecture, where softwaredescribed as a service oriented architecture. Several ofWhile a Service Oriented Architecture (usually implemented

  10. Optical Multiplexing for High-Throughput Spectroscopic Analysis.

    E-Print Network [OSTI]

    Ahmed, Saadiah

    2012-05-03T23:59:59.000Z

    in optical biosensor testing as it provides greater throughput and scalability while being an economical and compact solution. v NOMENCLATURE MFPF Multi Frequency Phase Fluorometer MUX Multiplexer LED Light Emitting Diode DIO Digital Input... oxidase in hybrid silicate microsphere that is coated with nanofilm and reference dye (RITC) (Fig. 1) [2]. The phosphorescent dye is excited by a green light from a LED (light emitting diode) to emit luminescence, the intensity of which is dependent...

  11. High Throughput Synthesis of Uniform Biocompatible Polymer Beads with High Quantum Dot Loading Using Microfluidic Jet-Mode Breakup

    E-Print Network [OSTI]

    Lee, Seung-Kon

    Uniform polymer microbeads with highly loaded quantum dots (QDs) are produced using high-throughput coherent jet breakup of a biocompatible poly(ethylene glycol) diacrylate (PEGDA) prepolymer resin, followed by in-line ...

  12. Low Cost Lithography Tool for High Brightness LED Manufacturing

    SciTech Connect (OSTI)

    Andrew Hawryluk; Emily True

    2012-06-30T23:59:59.000Z

    The objective of this activity was to address the need for improved manufacturing tools for LEDs. Improvements include lower cost (both capital equipment cost reductions and cost-ofownership reductions), better automation and better yields. To meet the DOE objective of $1- 2/kilolumen, it will be necessary to develop these highly automated manufacturing tools. Lithography is used extensively in the fabrication of high-brightness LEDs, but the tools used to date are not scalable to high-volume manufacturing. This activity addressed the LED lithography process. During R&D and low volume manufacturing, most LED companies use contact-printers. However, several industries have shown that these printers are incompatible with high volume manufacturing and the LED industry needs to evolve to projection steppers. The need for projection lithography tools for LED manufacturing is identified in the Solid State Lighting Manufacturing Roadmap Draft, June 2009. The Roadmap states that Projection tools are needed by 2011. This work will modify a stepper, originally designed for semiconductor manufacturing, for use in LED manufacturing. This work addresses improvements to yield, material handling, automation and throughput for LED manufacturing while reducing the capital equipment cost.

  13. Droplet microfluidic technology for single-cell high-throughput screening

    E-Print Network [OSTI]

    Perrimon, Norbert

    Droplet microfluidic technology for single-cell high-throughput screening Eric Brouzesa,b,1 (received for review March 31, 2009) We present a droplet-based microfluidic technology that enables high our droplet microfluidic platform is modular, robust, uses no moving parts, and has a wide range

  14. High-Throughput Contention-Free Concurrent Interleaver Architecture for Multi-Standard Turbo Decoder

    E-Print Network [OSTI]

    Mellor-Crummey, John

    High-Throughput Contention-Free Concurrent Interleaver Architecture for Multi-Standard Turbo paral- lel turbo decoder architectures have been developed. However, the interleaver has become a major that can efficiently solve the memory conflict problem for parallel turbo decoders with very high

  15. Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome

    E-Print Network [OSTI]

    Bourne, Philip E.

    Grid Portal Interface for Interactive Use and Monitoring of High-Throughput Proteome Annotation software on a high performance computing platform such as the grid. The Encyclopedia of Life (EOL) project application to drive grid software development. It is a flagship application for the TeraGrid project [3

  16. A Warm Near-Infrared High-Resolution Spectrograph with Very High Throughput (WINERED)

    E-Print Network [OSTI]

    Kondo, Sohei; Kobayashi, Naoto; Yasui, Chikako; Mito, Hiroyuki; Fukue, Kei; Nakanishi, Kenshi; Kawanishi, Takafumi; Nakaoka, Tetsuya; Otsubo, Shogo; Kinoshita, Masaomi; Kitano, Ayaka; Hamano, Satoshi; Mizumoto, Misaki; Yamamoto, Ryo; Izumi, Natsuko; Matsunaga, Noriyuki; Kawakita, Hideyo

    2015-01-01T23:59:59.000Z

    WINERED is a newly built high-efficiency (throughput$ > 25-30\\%$) and high-resolution spectrograph customized for short NIR bands at 0.9-1.35 ${\\rm \\mu}$m. WINERED is equipped with ambient temperature optics and a cryogenic camera using a 1.7 ${\\rm \\mu}$m cut-off HgCdTe HAWAII-2RG array detector. WINERED has two grating modes: one with a conventional reflective echelle grating (R$\\sim$28,300), which covers 0.9-1.35 $\\mu$m simultaneously, the other with ZnSe or ZnS immersion grating (R$\\sim$100,000). We have completed the development of WINERED except for the immersion grating, and started engineering and science observations at the Nasmyth platform of the 1.3 m Araki Telescope at Koyama Astronomical Observatory of Kyoto-Sangyo University in Japan. We confirmed that the spectral resolution ($R\\sim$ 28,300) and the throughput ($>$ 40\\% w/o telescope/atmosphere/array QE) meet our specifications. We measured ambient thermal backgrounds (e.g., 0.06 ${\\rm [e^{-}/sec/pixel]}$ at 287 K), which are roughly consistent ...

  17. Treatability studies on different refinery wastewater samples using high-throughput microbial electrolysis cells (MECs)

    E-Print Network [OSTI]

    Treatability studies on different refinery wastewater samples using high-throughput microbial, University Park, PA 16802, USA h i g h l i g h t s Refinery wastewaters were tested as fuels in MECs effective for treatment or pre-treatment of some refinery wastewaters. The best way to start up MECs

  18. Optical microplates for high-throughput screening of photosynthesis in lipid-producing algae{,

    E-Print Network [OSTI]

    Basu, Amar S.

    Optical microplates for high-throughput screening of photosynthesis in lipid- producing algae-producing algae of interest in 2nd generation biofuels. By conducting 96 experiments in parallel, photoirradiance the study of photosynthesis in algae. Societal challenges in energy sustainability have renewed interest

  19. Applied Catalysis A: General 254 (2003) 97106 Photoionization detection (PID) as a high throughput

    E-Print Network [OSTI]

    Senkan, Selim M.

    Applied Catalysis A: General 254 (2003) 97­106 Photoionization detection (PID) as a high throughput 2002 Abstract A versatile photoionization detection (PID) system has been developed to rapidly screen libraries of catalytic materials. The PID approach involves the use of an appropriately selected dc

  20. High-throughput imaging of heterogeneous cell organelles with an X-ray laser

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Hantke, Max, F.

    Preprocessed detector images that were used for the paper "High-throughput imaging of heterogeneous cell organelles with an X-ray laser". The CXI file contains the entire recorded data - including both hits and blanks. It also includes down-sampled images and LCLS machine parameters. Additionally, the Cheetah configuration file is attached that was used to create the pre-processed data.

  1. A High-Throughput Method to Examine Protein-Nucleotide Interactions Identifies Targets of the Bacterial

    E-Print Network [OSTI]

    A High-Throughput Method to Examine Protein- Nucleotide Interactions Identifies Targets can easily be applied to examine multiple protein-protein, protein-nucleotide and nucleotide-nucleotide Protein-Nucleotide Interactions Identifies Targets of the Bacterial Transcriptional Regulatory Protein Fur

  2. High-Throughput Screening of Gene Function in Stem Cells Using Clonal Microarrays

    E-Print Network [OSTI]

    Schaffer, David V.

    High-Throughput Screening of Gene Function in Stem Cells Using Clonal Microarrays RANDOLPH S. ASHTON,a JOSEPH PELTIER,b CHRISTOPHER A. FASANO,c ANALEAH O'NEILL,b JOSHUA LEONARD,b SALLY TEMPLE,c DAVID. Sox2 transcription factor Akt1 Neural progenitor cells Soft lithography ABSTRACT We describe

  3. HIGH-THROUGHPUT CELL AND PARTICLE CHARACTERIZATION USING ISO-DIELECTRIC

    E-Print Network [OSTI]

    Voldman, Joel

    HIGH-THROUGHPUT CELL AND PARTICLE CHARACTERIZATION USING ISO-DIELECTRIC SEPARATION Michael D. Vahey conductivity. Using a re- cently developed separation method - iso-dielectric separation (IDS) - we character for developing new screens. THEORY We recently developed a separa- tion method, called iso-dielectric sepa

  4. HIGH-THROUGHPUT COOPERATIVE TRANSMISSIONS USING ADAPTIVE COMPLEX-FIELD NETWORK CODING

    E-Print Network [OSTI]

    Pleite, Alfonso Cano

    HIGH-THROUGHPUT COOPERATIVE TRANSMISSIONS USING ADAPTIVE COMPLEX-FIELD NETWORK CODING Guobing Li1 , Alfonso Cano2 , and Georgios B. Giannakis2 1 School of Elect. and Info. Engr., Xi'an Jiaotong University. In this pa- per, a novel cooperation protocol is developed based on adap- tive complex-field wireless network

  5. automated high throughput: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of such a more database-centric approach. Roehm, Uwe 2009-01-01 31 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites...

  6. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    described here, which the research team believes will help usher in the next phase of genomics research. The high flux, brilliance, and focus of the x rays from ALS Beamline 12.3.1...

  7. High Throughput/Combinatorial Screening of Hydrogen Storage Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeatMulti-Dimensional Subject:Ground Hawaii HIGH PERFORMANCE andHighWellsfor

  8. High Throughput Combinatorial Screening of Biometic Metal-Organic Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeatMulti-Dimensional Subject:Ground Hawaii HIGH PERFORMANCE andHighWellsfor Military

  9. High Throughput/Combinatorial Screening of Hydrogen Storage Materials: UOP

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeatMulti-Dimensional Subject:Ground Hawaii HIGH PERFORMANCE andHighWellsforApproaches

  10. Uranium Transport in a High-Throughput Electrorefiner for EBR-II Blanket Fuel

    SciTech Connect (OSTI)

    Ahluwalia, Rajesh K.; Hua, Thanh Q.; Vaden, DeeEarl [Argonne National Laboratory (United States)

    2004-01-15T23:59:59.000Z

    A unique high-throughput Mk-V electrorefiner is being used in the electrometallurgical treatment of the metallic sodium-bonded blanket fuel from the Experimental Breeder Reactor II. Over many cycles, it transports uranium back and forth between the anodic fuel dissolution baskets and the cathode tubes until, because of imperfect adherence of the dendrites, it all ends up in the product collector at the bottom. The transport behavior of uranium in the high-throughput electrorefiner can be understood in terms of the sticking coefficients for uranium adherence to the cathode tubes in the forward direction and to the dissolution baskets in the reverse direction. The sticking coefficients are inferred from the experimental voltage and current traces and are correlated in terms of a single parameter representing the ratio of the cell current to the limiting current at the surface acting as the cathode. The correlations are incorporated into an engineering model that calculates the transport of uranium in the different modes of operation. The model also uses the experimentally derived electrorefiner operating maps that describe the relationship between the cell voltage and the cell current for the three principal transport modes. It is shown that the model correctly simulates the cycle-to-cycle variation of the voltage and current profiles. The model is used to conduct a parametric study of electrorefiner throughput rate as a function of the principal operating parameters. The throughput rate is found to improve with lowering of the basket rotation speed, reduction of UCl{sub 3} concentration in salt, and increasing the maximum cell current or cut-off voltage. Operating conditions are identified that can improve the throughput rate by 60 to 70% over that achieved at present.

  11. Automated Purification of Recombinant Proteins: Combining High-throughput

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone byDearTechnical InformationAugust 29,with High Yield. |

  12. Melter Throughput Enhancements for High-Iron HLW

    SciTech Connect (OSTI)

    Kruger, A. A. [Department of Energy, Office of River Protection, Richland, Washington (United States); Gan, Hoa [The Catholic University of America, Washington, DC (United States); Joseph, Innocent [The Catholic University of America, Washington, DC (United States); Pegg, Ian L. [The Catholic University of America, Washington, DC (United States); Matlack, Keith S. [The Catholic University of America, Washington, DC (United States); Chaudhuri, Malabika [The Catholic University of America, Washington, DC (United States); Kot, Wing [The Catholic University of America, Washington, DC (United States)

    2012-12-26T23:59:59.000Z

    This report describes work performed to develop and test new glass and feed formulations in order to increase glass melting rates in high waste loading glass formulations for HLW with high concentrations of iron. Testing was designed to identify glass and melter feed formulations that optimize waste loading and waste processing rate while meeting all processing and product quality requirements. The work included preparation and characterization of crucible melts to assess melt rate using a vertical gradient furnace system and to develop new formulations with enhanced melt rate. Testing evaluated the effects of waste loading on glass properties and the maximum waste loading that can be achieved. The results from crucible-scale testing supported subsequent DuraMelter 100 (DM100) tests designed to examine the effects of enhanced glass and feed formulations on waste processing rate and product quality. The DM100 was selected as the platform for these tests due to its extensive previous use in processing rate determination for various HLW streams and glass compositions.

  13. A high-throughput infrastructure for density functional theory calculations Anubhav Jain, Geoffroy Hautier, Charles J. Moore, Shyue Ping Ong, Christopher C. Fischer,

    E-Print Network [OSTI]

    Ceder, Gerbrand

    A high-throughput infrastructure for density functional theory calculations Anubhav Jain, Geoffroy-throughput computation Density functional theory Materials screening GGA Formation enthalpies a b s t r a c t The use of high-throughput density functional theory (DFT) calculations to screen for new materials and conduct

  14. High Throughput Computing Impact on Meta Genomics (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    SciTech Connect (OSTI)

    Gore, Brooklin [Morgridge Institute for Research] [Morgridge Institute for Research

    2011-10-12T23:59:59.000Z

    This presentation includes a brief background on High Throughput Computing, correlating gene transcription factors, optical mapping, genotype to phenotype mapping via QTL analysis, and current work on next gen sequencing.

  15. A High-Throughput Screen for Wnt/?-Catenin Signaling Pathway Modulators in Human iPSC-Derived Neural Progenitors

    E-Print Network [OSTI]

    Zhao, Wen-Ning

    Wnt/?-catenin signaling has emerged as a central player in pathways implicated in the pathophysiology and treatment of neuropsychiatric disorders. To identify potential novel therapeutics for these disorders, high-throughput ...

  16. Evaluation of Tavorite-Structured Cathode Materials for Lithium-Ion Batteries Using High-Throughput Computing

    E-Print Network [OSTI]

    Mueller, Tim

    Cathode materials with structure similar to the mineral tavorite have shown promise for use in lithium-ion batteries, but this class of materials is relatively unexplored. We use high-throughput density-functional-theory ...

  17. High-throughput data mined prediction of inorganic compounds and computational discovery of new lithium-ion battery cathode materials

    E-Print Network [OSTI]

    Hautier, Geoffroy (Geoffroy T. F.)

    2011-01-01T23:59:59.000Z

    The ability to computationally predict the properties of new materials, even prior to their synthesis, has been made possible due to the current accuracy of modern ab initio techniques. In some cases, high-throughput ...

  18. High Throughput Computing Impact on Meta Genomics (Metagenomics Informatics Challenges Workshop: 10K Genomes at a Time)

    ScienceCinema (OSTI)

    Gore, Brooklin [Morgridge Institute for Research

    2013-01-22T23:59:59.000Z

    This presentation includes a brief background on High Throughput Computing, correlating gene transcription factors, optical mapping, genotype to phenotype mapping via QTL analysis, and current work on next gen sequencing.

  19. Advances in high-throughput speed, low-latency communication for embedded instrumentation ( 7th Annual SFAF Meeting, 2012)

    ScienceCinema (OSTI)

    Jordan, Scott [Physik Instrumente

    2013-02-11T23:59:59.000Z

    Scott Jordan on "Advances in high-throughput speed, low-latency communication for embedded instrumentation" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  20. High Throughput Plasmid Sequencing with Illumina and CLC Bio (Seventh Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting 2012)

    ScienceCinema (OSTI)

    Athavale, Ajay [Monsanto

    2013-01-25T23:59:59.000Z

    Ajay Athavale (Monsanto) presents "High Throughput Plasmid Sequencing with Illumina and CLC Bio" at the 7th Annual Sequencing, Finishing, Analysis in the Future (SFAF) Meeting held in June, 2012 in Santa Fe, NM.

  1. A high-throughput, high-resolution spectrometer for mapping the heliopause and 3-D Solar Wind using He+ 30.4nm

    E-Print Network [OSTI]

    California at Berkeley, University of

    A high-throughput, high-resolution spectrometer for mapping the heliopause and 3-D Solar Wind using Entrance slit farm with ~ 1000 slits Photon counting imager Concave grating used near normal incidence >> Need a higher throughput diffuse EUV spectrometer solar wind respond to coronal

  2. High-Throughput, High-Precision Hot Testing Tool for High-Brightness

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:Year in3.pdfEnergy Health and Productivity QuestionnaireSingle Emitter |VolumeEnergyR

  3. Getter sputtering system for high-throughput fabrication of composition spreads

    SciTech Connect (OSTI)

    Gregoire, John M.; Dover, R. B. van; Jin Jing; Di Salvo, Francis J.; Abruna, Hector D. [Department of Physics, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States); Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States); Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853 (United States) and Cornell Fuel Cell Institute, Cornell University, Ithaca, New York 14853 (United States)

    2007-07-15T23:59:59.000Z

    We describe a sputtering system that can deposit composition spreads in an effectively UHV environment but which does not require the high-throughput paradigm to be compromised by a long pump down each time a target is changed. The system deploys four magnetron sputter guns in a cryoshroud (getter sputtering) which allows elements such as Ti and Zr to be deposited with minimal contamination by oxygen or other reactive background gases. The system also relies on custom substrate heaters to give rapid heating and cool down. The effectiveness of the gettering technique is evaluated, and example results obtained for catalytic activity of a pseudoternary composition spread are presented.

  4. High-throughput, single-worm tracking and analysis in Caenorhabditis elegans

    E-Print Network [OSTI]

    Yemini, Eviatar

    2013-01-08T23:59:59.000Z

    significantly impact worm phenotype. An assessment of the statistical ? indicates that, for popular behavioral features, roughly 10 worms discriminate a mean difference of two standard deviations from wild-type behavior with well over 90% power and, 20 worms... Measu remen ts Enviro nment al Restri ctions Other Benef its Table 2.1: Single-Worm Tracker Comparison High-Throughput, Single-Worm Tracking and Analysis in C. elegans 20 Figure 2.1: WT1 Tracking Hardware A picture of the WT1 hardware...

  5. High-Throughput Thin Film Approach for Screening of Temperature-Pressure-Composition Phase Space

    SciTech Connect (OSTI)

    Zakutayev, A.; Subramaniyan, A.; Caskey, C. M.; Ndione, P. F.; Richards, R. M.; O'Hayre, R.; Ginley, D. S.

    2013-01-01T23:59:59.000Z

    Many solar energy technologies, for example CIGS and CdTe photovoltaics, utilize materials in thin film form. The equilibrium phase diagrams for these and other more novel solar energy materials are not known or are irrelevant because of the non-equilibrium character of the thin film growth processes. We demonstrate a high-throughput thin film approach for screening of temperature-pressure-composition phase diagrams and phase spaces. The examples in focus are novel solar absorbers Cu-N, Cu-O and p-type transparent conductors in the Cr2O3-MnO system. The composition axis of the Cr2O3-MnO phase diagram was screened using a composition spread method. The temperature axis of the Mn-O phase diagram was screened using a temperature spread method. The pressure axes of the Cu-N and Cu-O phase diagrams were screened using rate spread method with the aid of non-equilibrium growth phenomena. Overall these three methods constitute an approach to high-throughput screening of inorganic thin film phase diagrams. This research is supported by U.S. Department of Energy as a part of two NextGen Sunshot projects and an Energy Frontier Research Center.

  6. Development of a high-throughput microfluidic integrated microarray for the detection of chimeric bioweapons.

    SciTech Connect (OSTI)

    Sheppod, Timothy; Satterfield, Brent; Hukari, Kyle W.; West, Jason A. A.; Hux, Gary A.

    2006-10-01T23:59:59.000Z

    The advancement of DNA cloning has significantly augmented the potential threat of a focused bioweapon assault, such as a terrorist attack. With current DNA cloning techniques, toxin genes from the most dangerous (but environmentally labile) bacterial or viral organism can now be selected and inserted into robust organism to produce an infinite number of deadly chimeric bioweapons. In order to neutralize such a threat, accurate detection of the expressed toxin genes, rather than classification on strain or genealogical decent of these organisms, is critical. The development of a high-throughput microarray approach will enable the detection of unknowns chimeric bioweapons. The development of a high-throughput microarray approach will enable the detection of unknown bioweapons. We have developed a unique microfluidic approach to capture and concentrate these threat genes (mRNA's) upto a 30 fold concentration. These captured oligonucleotides can then be used to synthesize in situ oligonucleotide copies (cDNA probes) of the captured genes. An integrated microfluidic architecture will enable us to control flows of reagents, perform clean-up steps and finally elute nanoliter volumes of synthesized oligonucleotides probes. The integrated approach has enabled a process where chimeric or conventional bioweapons can rapidly be identified based on their toxic function, rather than being restricted to information that may not identify the critical nature of the threat.

  7. Heterogeneous High Throughput Scientific Computing with APM X-Gene and Intel Xeon Phi

    E-Print Network [OSTI]

    David Abdurachmanov; Brian Bockelman; Peter Elmer; Giulio Eulisse; Robert Knight; Shahzad Muzaffar

    2014-10-10T23:59:59.000Z

    Electrical power requirements will be a constraint on the future growth of Distributed High Throughput Computing (DHTC) as used by High Energy Physics. Performance-per-watt is a critical metric for the evaluation of computer architectures for cost- efficient computing. Additionally, future performance growth will come from heterogeneous, many-core, and high computing density platforms with specialized processors. In this paper, we examine the Intel Xeon Phi Many Integrated Cores (MIC) co-processor and Applied Micro X-Gene ARMv8 64-bit low-power server system-on-a-chip (SoC) solutions for scientific computing applications. We report our experience on software porting, performance and energy efficiency and evaluate the potential for use of such technologies in the context of distributed computing systems such as the Worldwide LHC Computing Grid (WLCG).

  8. Development and operation of a high-throughput accurate-wavelength lens-based spectrometer

    SciTech Connect (OSTI)

    Bell, Ronald E., E-mail: rbell@pppl.gov [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 (United States)

    2014-11-15T23:59:59.000Z

    A high-throughput spectrometer for the 400820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm{sup ?1} grating is matched with fast f/1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy ?0.075 arc sec. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount at the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  9. Development and Operation of High-throughput Accurate-wavelength Lens-based Spectrometer

    SciTech Connect (OSTI)

    Bell, Ronald E

    2014-07-01T23:59:59.000Z

    A high-throughput spectrometer for the 400-820 nm wavelength range has been developed for charge exchange recombination spectroscopy or general spectroscopy. A large 2160 mm-1 grating is matched with fast f /1.8 200 mm lenses, which provide stigmatic imaging. A precision optical encoder measures the grating angle with an accuracy < 0.075 arc seconds. A high quantum efficiency low-etaloning CCD detector allows operation at longer wavelengths. A patch panel allows input fibers to interface with interchangeable fiber holders that attach to a kinematic mount behind the entrance slit. Computer-controlled hardware allows automated control of wavelength, timing, f-number, automated data collection, and wavelength calibration.

  10. Integrated crystal mounting and alignment system for high-throughput biological crystallography

    DOE Patents [OSTI]

    Nordmeyer, Robert A.; Snell, Gyorgy P.; Cornell, Earl W.; Kolbe, William; Yegian, Derek; Earnest, Thomas N.; Jaklevic, Joseph M.; Cork, Carl W.; Santarsiero, Bernard D.; Stevens, Raymond C.

    2005-07-19T23:59:59.000Z

    A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.

  11. Integrated crystal mounting and alignment system for high-throughput biological crystallography

    DOE Patents [OSTI]

    Nordmeyer, Robert A. (San Leandro, CA); Snell, Gyorgy P. (Richmond, CA); Cornell, Earl W. (Antioch, CA); Kolbe, William F. (Moraga, CA); Yegian, Derek T. (Oakland, CA); Earnest, Thomas N. (Berkeley, CA); Jaklevich, Joseph M. (Lafayette, CA); Cork, Carl W. (Walnut Creek, CA); Santarsiero, Bernard D. (Chicago, IL); Stevens, Raymond C. (La Jolla, CA)

    2007-09-25T23:59:59.000Z

    A method and apparatus for the transportation, remote and unattended mounting, and visual alignment and monitoring of protein crystals for synchrotron generated x-ray diffraction analysis. The protein samples are maintained at liquid nitrogen temperatures at all times: during shipment, before mounting, mounting, alignment, data acquisition and following removal. The samples must additionally be stably aligned to within a few microns at a point in space. The ability to accurately perform these tasks remotely and automatically leads to a significant increase in sample throughput and reliability for high-volume protein characterization efforts. Since the protein samples are placed in a shipping-compatible layered stack of sample cassettes each holding many samples, a large number of samples can be shipped in a single cryogenic shipping container.

  12. Nanoelectrospray ion generation for high-throughput mass spectrometry using a micromachined ultrasonic ejector array

    SciTech Connect (OSTI)

    Aderogba, S.; Meacham, J.M.; Degertekin, F.L.; Fedorov, A.G.; Fernandez, F.M. [G.W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States); School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332 (United States)

    2005-05-16T23:59:59.000Z

    Ultrasonic electrospray ionization (ESI) for high-throughput mass spectrometry is demonstrated using a silicon micromachined microarray. The device uses a micromachined ultrasonic atomizer operating in the 900 kHz-2.5 MHz range for droplet generation and a metal electrode in the fluid cavity for ionization. Since the atomization and ionization processes are separated, the ultrasonic ESI source shows the potential for operation at low voltages with a wide range of solvents in contrast with conventional capillary ESI technology. This is demonstrated using the ultrasonic ESI microarray to obtain the mass spectrum of a 10 {mu}M reserpine sample on a time of flight mass spectrometer with 197:1 signal-to-noise ratio at an ionization potential of 200 V.

  13. An infrared imaging method for high-throughput combinatorial investigation of hydrogenation-dehydrogenation and new phase

    E-Print Network [OSTI]

    Rubloff, Gary W.

    An infrared imaging method for high-throughput combinatorial investigation of hydrogenation Received 9 April 2009; accepted 30 June 2009; published online 30 July 2009 We have developed an infrared imaging setup enabling in situ infrared images to be acquired, and expanded on capabilities of an infrared

  14. PIPELINED PARALLEL ARCHITECTURE FOR HIGH THROUGHPUT MAP DETECTORS Ruwan Ratnayake, Gu-Yeon Wei and Aleksandar Kavcic

    E-Print Network [OSTI]

    Kavcic, Aleksandar

    PIPELINED PARALLEL ARCHITECTURE FOR HIGH THROUGHPUT MAP DETECTORS Ruwan Ratnayake, Gu-Yeon Wei performance close to the channel capacity limits. Deep pipelined architecture for the forward only method, where as FB-BCJR only allow sequential state metric computations. Parallelism facilitates pipelining, re

  15. IEEE TRANSACTIONS ON MEDICAL IMAGING, VOL. 32, NO. 10, OCTOBER 2013 1791 DevStaR: High-Throughput Quantification

    E-Print Network [OSTI]

    Sontag, Eduardo

    of C. elegans embryonic viability in high-throughput (HTP) applications. A leading genetic model organism for the study of animal development and behavior, C. elegans is particularly amenable to HTP the algorithmic design of the DevStaR system and demonstrate its performance in scoring image data acquired in HTP

  16. A Cross-Referencing-Based Droplet Manipulation Method for High-Throughput and Pin-Constrained Digital Microfluidic Arrays*

    E-Print Network [OSTI]

    Chakrabarty, Krishnendu

    -Constrained Digital Microfluidic Arrays* Tao Xu and Krishnendu Chakrabarty Department of Electrical and Computer Engineering Duke University, Durham, NC 27708, USA {tx, krish}@ee.duke.edu Abstract Digital microfluidic. As high-throughput bioassays are mapped to digital microfluidic platforms, the need for design automation

  17. A search model for topological insulators with high-throughput robustness descriptors

    SciTech Connect (OSTI)

    Yang, Kesong; Setyawan, Wahyu; Wang, Shidong; Nardelli, Marco B.; Curtarolo, Stephano

    2012-05-13T23:59:59.000Z

    Topological insulators (TI) are becoming one of the most studied classes of novel materials because of their great potential for applications ranging from spintronics to quantum computers. To fully integrate TI materials in electronic devices, high-quality epitaxial single-crystalline phases with sufficiently large bulk bandgaps are necessary. Current efforts have relied mostly on costly and time-consuming trial-and-error procedures. Here we show that by defining a reliable and accessible descriptor {cflx X}TI, which represents the topological robustness or feasibility of the candidate, and by searching the quantum materials repository aflowlib.org, we have automatically discovered 28 TIs (some of them already known) in five different symmetry families. These include peculiar ternary halides, Cs{l_brace}Sn,Pb,Ge{r_brace}{l_brace}Cl,Br,I{r_brace}{sub 3}, which could have been hardly anticipated without high-throughput means. Our search model, by relying on the significance of repositories in materials development, opens new avenues for the discovery of more TIs in different and unexplored classes of systems.

  18. FBI Fingerprint Image Capture System High-Speed-Front-End throughput modeling

    SciTech Connect (OSTI)

    Rathke, P.M.

    1993-09-01T23:59:59.000Z

    The Federal Bureau of Investigation (FBI) has undertaken a major modernization effort called the Integrated Automated Fingerprint Identification System (IAFISS). This system will provide centralized identification services using automated fingerprint, subject descriptor, mugshot, and document processing. A high-speed Fingerprint Image Capture System (FICS) is under development as part of the IAFIS program. The FICS will capture digital and microfilm images of FBI fingerprint cards for input into a central database. One FICS design supports two front-end scanning subsystems, known as the High-Speed-Front-End (HSFE) and Low-Speed-Front-End, to supply image data to a common data processing subsystem. The production rate of the HSFE is critical to meeting the FBI`s fingerprint card processing schedule. A model of the HSFE has been developed to help identify the issues driving the production rate, assist in the development of component specifications, and guide the evolution of an operations plan. A description of the model development is given, the assumptions are presented, and some HSFE throughput analysis is performed.

  19. Evaluation of a New Remote Handling Design for High Throughput Annular Centrifugal Contactors

    SciTech Connect (OSTI)

    David H. Meikrantz; Troy G. Garn; Jack D. Law; Lawrence L. Macaluso

    2009-09-01T23:59:59.000Z

    Advanced designs of nuclear fuel recycling plants are expected to include more ambitious goals for aqueous based separations including; higher separations efficiency, high-level waste minimization, and a greater focus on continuous processes to minimize cost and footprint. Therefore, Annular Centrifugal Contactors (ACCs) are destined to play a more important role for such future processing schemes. Previous efforts defined and characterized the performance of commercial 5 cm and 12.5 cm single-stage ACCs in a cold environment. The next logical step, the design and evaluation of remote capable pilot scale ACCs in a hot or radioactive environment was reported earlier. This report includes the development of remote designs for ACCs that can process the large throughput rates needed in future nuclear fuel recycling plants. Novel designs were developed for the remote interconnection of contactor units, clean-in-place and drain connections, and a new solids removal collection chamber. A three stage, 12.5 cm diameter rotor module has been constructed and evaluated for operational function and remote handling in highly radioactive environments. This design is scalable to commercial CINC ACC models from V-05 to V-20 with total throughput rates ranging from 20 to 650 liters per minute. The V-05R three stage prototype was manufactured by the commercial vendor for ACCs in the U.S., CINC mfg. It employs three standard V-05 clean-in-place (CIP) units modified for remote service and replacement via new methods of connection for solution inlets, outlets, drain and CIP. Hydraulic testing and functional checks were successfully conducted and then the prototype was evaluated for remote handling and maintenance suitability. Removal and replacement of the center position V-05R ACC unit in the three stage prototype was demonstrated using an overhead rail mounted PaR manipulator. This evaluation confirmed the efficacy of this innovative design for interconnecting and cleaning individual stages while retaining the benefits of commercially reliable ACC equipment for remote applications in the nuclear industry. Minor modifications and suggestions for improved manual remote servicing by the remote handling specialists were provided but successful removal and replacement was demonstrated in the first prototype.

  20. VLPW: The Very Long Packet Window Architecture for High Throughput Network-On-Chip Router Designs

    E-Print Network [OSTI]

    Gu, Haiyin

    2012-10-19T23:59:59.000Z

    -chip routers and the ideal interconnect fabric. To improve throughput, VLPW optimizes Switch Allocation (SA) efficiency. Existing SA normally applies Round-Robin scheduling to arbitrate among the packets targeting the same output port. However, this simple...

  1. High Throughput Software for Powder Diffraction and its Application to Heterogeneous Catalysis

    E-Print Network [OSTI]

    Taha Sochi

    2010-12-20T23:59:59.000Z

    In this thesis we investigate high throughput computational methods for processing large quantities of data collected from synchrotrons and their application to spectral analysis of powder diffraction data. We also present the main product of this PhD programme, specifically a software called 'EasyDD' developed by the author. This software was created to meet the increasing demand on data processing and analysis capabilities as required by modern detectors which produce huge quantities of data. Modern detectors coupled with the high intensity X-ray sources available at synchrotrons have led to the situation where datasets can be collected in ever shorter time scales and in ever larger numbers. Such large volumes of datasets pose a data processing bottleneck which augments with current and future instrument development. EasyDD has achieved its objectives and made significant contributions to scientific research. It can also be used as a model for more mature attempts in the future. EasyDD is currently in use by a number of researchers in a number of academic and research institutions to process high-energy diffraction data. These include data collected by different techniques such as Energy Dispersive Diffraction, Angle Dispersive Diffraction and Computer Aided Tomography. EasyDD has already been used in a number of published studies, and is currently in use by the High Energy X-Ray Imaging Technology project. The software was also used by the author to process and analyse datasets collected from synchrotron radiation facilities. In this regard, the thesis presents novel scientific research involving the use of EasyDD to handle large diffraction datasets in the study of alumina-supported metal oxide catalyst bodies. These data were collected using Tomographic Energy Dispersive Diffraction Imaging and Computer Aided Tomography techniques.

  2. Integrated Controlling System and Unified Database for High Throughput Protein Crystallography Experiments

    SciTech Connect (OSTI)

    Gaponov, Yu.A.; Igarashi, N.; Hiraki, M.; Sasajima, K.; Matsugaki, N.; Suzuki, M.; Kosuge, T.; Wakatsuki, S. [Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba (Japan)

    2004-05-12T23:59:59.000Z

    An integrated controlling system and a unified database for high throughput protein crystallography experiments have been developed. Main features of protein crystallography experiments (purification, crystallization, crystal harvesting, data collection, data processing) were integrated into the software under development. All information necessary to perform protein crystallography experiments is stored (except raw X-ray data that are stored in a central data server) in a MySQL relational database. The database contains four mutually linked hierarchical trees describing protein crystals, data collection of protein crystal and experimental data processing. A database editor was designed and developed. The editor supports basic database functions to view, create, modify and delete user records in the database. Two search engines were realized: direct search of necessary information in the database and object oriented search. The system is based on TCP/IP secure UNIX sockets with four predefined sending and receiving behaviors, which support communications between all connected servers and clients with remote control functions (creating and modifying data for experimental conditions, data acquisition, viewing experimental data, and performing data processing). Two secure login schemes were designed and developed: a direct method (using the developed Linux clients with secure connection) and an indirect method (using the secure SSL connection using secure X11 support from any operating system with X-terminal and SSH support). A part of the system has been implemented on a new MAD beam line, NW12, at the Photon Factory Advanced Ring for general user experiments.

  3. A microreactor array for spatially resolved measurement of catalytic activity for high-throughput catalysis science

    SciTech Connect (OSTI)

    Kondratyuk, Petro; Gumuslu, Gamze; Shukla, Shantanu; Miller, James B.; Morreale, Bryan D.; Gellman, Andrew J.

    2013-04-01T23:59:59.000Z

    We describe a 100 channel microreactor array capable of spatially resolved measurement of catalytic activity across the surface of a flat substrate. When used in conjunction with a composition spread alloy film (CSAF, e.g. Pd{sub x}Cu{sub y}Au{sub 1-x-y}) across which component concentrations vary smoothly, such measurements permit high-throughput analysis of catalytic activity and selectivity as a function of catalyst composition. In the reported implementation, the system achieves spatial resolution of 1 mm{sup 2} over a 1010 mm{sup 2} area. During operation, the reactant gases are delivered at constant flow rate to 100 points of differing composition on the CSAF surface by means of a 100-channel microfluidic device. After coming into contact with the CSAF catalyst surface, the product gas mixture from each of the 100 points is withdrawn separately through a set of 100 isolated channels for analysis using a mass spectrometer. We demonstrate the operation of the device on a Pd{sub x}Cu{sub y}Au{sub 1-x-y} CSAF catalyzing the H{sub 2}-D{sub 2} exchange reaction at 333 K. In essentially a single experiment, we measured the catalytic activity over a broad swathe of concentrations from the ternary composition space of the Pd{sub x}Cu{sub y}Au{sub 1-x-y} alloy.

  4. PHYSICAL REVIEW B 84, 014103 (2011) Screening for high-performance piezoelectrics using high-throughput density functional theory

    E-Print Network [OSTI]

    Ceder, Gerbrand

    -throughput density functional theory Rickard Armiento,1 Boris Kozinsky,2 Marco Fornari,3 and Gerbrand Ceder1 1-scale density functional theory (DFT) investigation of the ABO3 chemical space in the perovskite crystal-throughput density functional theory19,20 calculations. The last decades have seen a rapid increase of computational

  5. Soft inertial microfluidics for high throughput separation of bacteria from human blood cells

    SciTech Connect (OSTI)

    Wu, Zhigang; Willing, Ben; Bjerketorp, Joakim; Jansson, Janet K.; Hjort, Klas

    2009-01-05T23:59:59.000Z

    We developed a new approach to separate bacteria from human blood cells based on soft inertial force induced migration with flow defined curved and focused sample flow inside a microfluidic device. This approach relies on a combination of an asymmetrical sheath flow and proper channel geometry to generate a soft inertial force on the sample fluid in the curved and focused sample flow segment to deflect larger particles away while the smaller ones are kept on or near the original flow streamline. The curved and focused sample flow and inertial effect were visualized and verified using a fluorescent dye primed in the device. First the particle behavior was studied in detail using 9.9 and 1.0 {micro}m particles with a polymer-based prototype. The prototype device is compact with an active size of 3 mm{sup 2}. The soft inertial effect and deflection distance were proportional to the fluid Reynolds number (Re) and particle Reynolds number (Re{sub p}), respectively. We successfully demonstrated separation of bacteria (Escherichia coli) from human red blood cells at high cell concentrations (above 10{sup 8}/mL), using a sample flow rate of up to 18 {micro}L/min. This resulted in at least a 300-fold enrichment of bacteria at a wide range of flow rates with a controlled flow spreading. The separated cells were proven to be viable. Proteins from fractions before and after cell separation were analyzed by gel electrophoresis and staining to verify the removal of red blood cell proteins from the bacterial cell fraction. This novel microfluidic process is robust, reproducible, simple to perform, and has a high throughput compared to other cell sorting systems. Microfluidic systems based on these principles could easily be manufactured for clinical laboratory and biomedical applications.

  6. New Challenges of the Computation of Multiple Sequence Alignments in the High-Throughput Era (2010 JGI/ANL HPC Workshop)

    ScienceCinema (OSTI)

    Notredame, Cedric [Centre for Genomic Regulation

    2011-06-08T23:59:59.000Z

    Cedric Notredame from the Centre for Genomic Regulation gives a presentation on "New Challenges of the Computation of Multiple Sequence Alignments in the High-Throughput Era" at the JGI/Argonne HPC Workshop on January 26, 2010.

  7. Advanced Environments and Tools for High Performance Computing

    E-Print Network [OSTI]

    Walker, David W.

    Advanced Environments and Tools for High Performance Computing Problem-Solving Environments Environments and Tools for High Performance Computing. The conference was chaired by Professor D. W. Walker and managing distributed high performance comput- ing resources is important for a PSE to meet the requirements

  8. Feasibility and Design Studies for a High Temperature Downhole Tool

    Broader source: Energy.gov [DOE]

    Project objective: Perform feasibility and design studies for a high temperature downhole tool; which uses nuclear techniques for characterization purposes; using measurements and modeling/simulation.

  9. Scalable Computational Methods for the Analysis of High-Throughput Biological Data

    SciTech Connect (OSTI)

    Langston, Michael A.

    2012-09-06T23:59:59.000Z

    This primary focus of this research project is elucidating genetic regulatory mechanisms that control an organism?¢????s responses to low-dose ionizing radiation. Although low doses (at most ten centigrays) are not lethal to humans, they elicit a highly complex physiological response, with the ultimate outcome in terms of risk to human health unknown. The tools of molecular biology and computational science will be harnessed to study coordinated changes in gene expression that orchestrate the mechanisms a cell uses to manage the radiation stimulus. High performance implementations of novel algorithms that exploit the principles of fixed-parameter tractability will be used to extract gene sets suggestive of co-regulation. Genomic mining will be performed to scrutinize, winnow and highlight the most promising gene sets for more detailed investigation. The overall goal is to increase our understanding of the health risks associated with exposures to low levels of radiation.

  10. Assessment of advanced coal-gasification processes. [AVCO high throughput gasification in process; Bell High Mass Flux process; CS-R process; and Exxon Gasification process

    SciTech Connect (OSTI)

    McCarthy, J.; Ferrall, J.; Charng, T.; Houseman, J.

    1981-06-01T23:59:59.000Z

    This report represents a technical assessment of the following advanced coal gasification processes: AVCO High Throughput Gasification (HTG) Process, Bell Single - Stage High Mass Flux (HMF) Process, Cities Service/Rockwell (CS/R) Hydrogasification Process, and the Exxon Catalytic Coal Gasification (CCG) Process. Each process is evaluated for its potential to produce SNG from a bituminous coal. In addition to identifying the new technology these processes represent, key similarities/differences, strengths/weaknesses, and potential improvements to each process are identified. The AVCO HTG and the Bell HMF gasifiers share similarities with respect to: short residence time (SRT), high throughput rate, slagging and syngas as the initial raw product gas. The CS/R Hydrogasifier is also SRT but is non-slagging and produces a raw gas high in methane content. The Exxon CCG gasifier is a long residence time, catalytic fluidbed reactor producing all of the raw product methane in the gasifier.

  11. Geochip: A high throughput genomic tool for linking community structure to functions

    E-Print Network [OSTI]

    Van Nostrand, Joy D.

    2009-01-01T23:59:59.000Z

    soil samples from two oilfields, Daqing and Shengli, locatedall samples from the Daqing oilfield grouping together whilecommunity from the Shengli oilfield was separate (Figure 2),

  12. Algorithms and tools for high-throughput geometry-based analysis of

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation InInformationCenterResearch Highlights MediaFuelAbout UsAdvisory PanelsTechnologies

  13. E-Print Network 3.0 - analyzing high-throughput sequencing Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and managed by Collection: Renewable Energy 2 Applying model-based methods to analyze genomics data Zhaohui Qin Summary: tools to extract scientific insights from massive and noisy...

  14. RECENT PROCESS AND EQUIPMENT IMPROVEMENTS TO INCREASE HIGH LEVEL WASTE THROUGHPUT AT THE DEFENSE WASTE PROCESSING FACILITY

    SciTech Connect (OSTI)

    Odriscoll, R; Allan Barnes, A; Jim Coleman, J; Timothy Glover, T; Robert Hopkins, R; Dan Iverson, D; Jeff Leita, J

    2008-01-15T23:59:59.000Z

    The Savannah River Site's (SRS) Defense Waste Processing Facility (DWPF) began stabilizing high level waste (HLW) in a glass matrix in 1996. Over the past few years, there have been several process and equipment improvements at the DWPF to increase the rate at which the high level waste can be stabilized. These improvements have either directly increased waste processing rates or have desensitized the process to upsets, thereby minimizing downtime and increasing production. Improvements due to optimization of waste throughput with increased HLW loading of the glass resulted in a 6% waste throughput increase based upon operational efficiencies. Improvements in canister production include the pour spout heated bellows liner (5%), glass surge (siphon) protection software (2%), melter feed pump software logic change to prevent spurious interlocks of the feed pump with subsequent dilution of feed stock (2%) and optimization of the steam atomized scrubber (SAS) operation to minimize downtime (3%) for a total increase in canister production of 12%. A number of process recovery efforts have allowed continued operation. These include the off gas system pluggage and restoration, slurry mix evaporator (SME) tank repair and replacement, remote cleaning of melter top head center nozzle, remote melter internal inspection, SAS pump J-Tube recovery, inadvertent pour scenario resolutions, dome heater transformer bus bar cooling water leak repair and new Infra-red camera for determination of glass height in the canister are discussed.

  15. High power laser perforating tools and systems

    DOE Patents [OSTI]

    Zediker, Mark S; Rinzler, Charles C; Faircloth, Brian O; Koblick, Yeshaya; Moxley, Joel F

    2014-04-22T23:59:59.000Z

    ystems devices and methods for the transmission of 1 kW or more of laser energy deep into the earth and for the suppression of associated nonlinear phenomena. Systems, devices and methods for the laser perforation of a borehole in the earth. These systems can deliver high power laser energy down a deep borehole, while maintaining the high power to perforate such boreholes.

  16. Operations capability improvement of a molecular biology laboratory in a high throughput genome sequencing center

    E-Print Network [OSTI]

    Vokoun, Matthew R. (Matthew Richard)

    2005-01-01T23:59:59.000Z

    The Broad Institute is a research collaboration of MIT, Harvard University and affiliated hospitals, and the Whitehead Institute for Biomedical Research. Its scientific mission is to "(1) create tools for genomic medicine ...

  17. Determination of gene expression patterns using high-throughput RNA in situ hybridizaion to whole-mount Drosophila embryos

    SciTech Connect (OSTI)

    Weiszmann, R.; Hammonds, A.S.; Celniker, S.E.

    2009-04-09T23:59:59.000Z

    We describe a high-throughput protocol for RNA in situ hybridization (ISH) to Drosophila embryos in a 96-well format. cDNA or genomic DNA templates are amplified by PCR and then digoxigenin-labeled ribonucleotides are incorporated into antisense RNA probes by in vitro transcription. The quality of each probe is evaluated before ISH using a RNA probe quantification (dot blot) assay. RNA probes are hybridized to fixed, mixed-staged Drosophila embryos in 96-well plates. The resulting stained embryos can be examined and photographed immediately or stored at 4oC for later analysis. Starting with fixed, staged embryos, the protocol takes 6 d from probe template production through hybridization. Preparation of fixed embryos requires a minimum of 2 weeks to collect embryos representing all stages. The method has been used to determine the expression patterns of over 6,000 genes throughout embryogenesis.

  18. High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics

    SciTech Connect (OSTI)

    Pan, Jian-Bo [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Nan; Pan, Wen; Hong, Ru [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Wang, Hao [Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China); Ji, Zhi-Liang, E-mail: appo@xmu.edu.cn [State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102 (China); Department of Chemical Biology, College of Chemistry and Chemical Engineering, The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005 (China)

    2014-01-01T23:59:59.000Z

    Drugs may induce adverse drug reactions (ADRs) when they unexpectedly bind to proteins other than their therapeutic targets. Identification of these undesired protein binding partners, called off-targets, can facilitate toxicity assessment in the early stages of drug development. In this study, a computational framework was introduced for the exploration of idiosyncratic mechanisms underlying analgesic-induced severe adverse drug reactions (SADRs). The putative analgesic-target interactions were predicted by performing reverse docking of analgesics or their active metabolites against human/mammal protein structures in a high-throughput manner. Subsequently, bioinformatics analyses were undertaken to identify ADR-associated proteins (ADRAPs) and pathways. Using the pathways and ADRAPs that this analysis identified, the mechanisms of SADRs such as cardiac disorders were explored. For instance, 53 putative ADRAPs and 24 pathways were linked with cardiac disorders, of which 10 ADRAPs were confirmed by previous experiments. Moreover, it was inferred that pathways such as base excision repair, glycolysis/glyconeogenesis, ErbB signaling, calcium signaling, and phosphatidyl inositol signaling likely play pivotal roles in drug-induced cardiac disorders. In conclusion, our framework offers an opportunity to globally understand SADRs at the molecular level, which has been difficult to realize through experiments. It also provides some valuable clues for drug repurposing. - Highlights: A novel computational framework was developed for mechanistic study of SADRs. Off-targets of drugs were identified in large scale and in a high-throughput manner. SADRs like cardiac disorders were systematically explored in molecular networks. A number of ADR-associated proteins were identified.

  19. A General Framework for Development and Data Analysis of Competitive High-Throughput Screens for Small-Molecule Inhibitors of Protein-Protein

    E-Print Network [OSTI]

    ). Recent advances in chemical biology and high-throughput (HTP)1 screening (13-15) have introduced the use sensitive, robust, and widely used HTP methods for the study of protein interactions and drug discovery (19, can serve as a sensitive molecular sensor. HTP FP assays usually detect changes in polarization caused

  20. 494 IEEE TRANSACTIONS ON VERY LARGE SCALE INTEGRATION (VLSI) SYSTEMS, VOL. 13, NO. 4, APRIL 2005 Memory Sub-Banking Scheme for High Throughput

    E-Print Network [OSTI]

    Kambhampati, Subbarao

    decoding latency, and reduced memory energy consumption. Our contributions include deriva- tion, and energy consumption and provide a tradeoff analysis between the different parameters. The main implementations (both single port and dual port) of the SW SISO decoder that achieves high throughput, low

  1. array-based high throughput: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roehm, Uwe 2009-01-01 13 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...

  2. aureus strains high-throughput: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roehm, Uwe 2009-01-01 14 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...

  3. antileishmanial high-throughput drug: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Roehm, Uwe 2009-01-01 22 DOE Workshop HIGH THROUGHPUTCOMBINATORIAL SCREENING Energy Storage, Conversion and Utilization Websites Summary: and academic labs. Pioneer...

  4. Development of a high-throughput fermentation assay using colorimetric measurement of gas production.

    E-Print Network [OSTI]

    Bly, Steven

    2008-01-01T23:59:59.000Z

    ??Typical methods for determining ethanol production from biomass feedstocks involve the use of High Performance Liquid Chromatography (HPLC) or Gas Chromatography (GC). Such methods require (more)

  5. High Throughput Ultralong (20 cm) Nanowire Fabrication Using a Wafer-Scale Nanograting Template

    E-Print Network [OSTI]

    -gu, Daejeon, 305-701, Republic of Korea LG Innotek Components & Materials R&D Center, 55 Hanyang Daehak actively explored as promising nanostructured materials for high performance flexible electronics (centimeter- long) nanowires are highly attractive from the perspective of electronic performance, device

  6. Application of High Throughput Pretreatment and Co-Hydrolysis System to Thermochemical

    E-Print Network [OSTI]

    California at Riverside, University of

    and enzymatic hydrolysis conditions. Although hydrothermal pretreatment is currently being employed in most high were compared to results from hydrothermal pretreatments, providing new insights in understanding their recalcitrance and consolidating processing of enzymes and microorganisms to overcome biomass recalci- trance

  7. High throughput lessons from the LHC experience.Johnston.TNC2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickr FlickrGuidedCH2M HILLAdministrationHighHigh oil productionhigh

  8. Interfacing Capillary Electrophoresis and 2D-Infrared Spectroscopy for High Throughput Proteomics

    E-Print Network [OSTI]

    Rosso, Lula

    and parameters defining the wettability of the substrate plate such as buffer conductivity, applied electric efficiency, the sample therefore needs to be concentrated onto an area while a linear motor stage is translating the substrate plate beneath. A high analyte area Optical

  9. Air-stable ink for scalable, high-throughput layer deposition

    DOE Patents [OSTI]

    Weil, Benjamin D; Connor, Stephen T; Cui, Yi

    2014-02-11T23:59:59.000Z

    A method for producing and depositing air-stable, easily decomposable, vulcanized ink on any of a wide range of substrates is disclosed. The ink enables high-volume production of optoelectronic and/or electronic devices using scalable production methods, such as roll-to-roll transfer, fast rolling processes, and the like.

  10. Development of a multiplexed microbioreactor system for high-throughput bioprocessing

    E-Print Network [OSTI]

    Sinskey, Anthony J.

    . However, this is a challenge with current bioreactor technology. The high cost and labor required and fluidic connectors, their sterilization, and disassembly and cleaning. While some fermentation parameters), for example, operates six reactors in parallel, and the ``Fedbatch-Pro'' (DASGIP AG, Germany) includes up

  11. On-the-fly machine-learning for high-throughput experiments: search for rare-earth-free permanent magnets

    SciTech Connect (OSTI)

    Kusne, Aaron Gilad [University of Maryland; Gao, Tieren [University of Maryland; Mehta, Apurva [SLAC National Accelerator Laboratory; Ke, Liqin [Ames Laboratory; Nguyen, Manh Cuong [Ames Laboratory; Ho, Kai-Ming [Ames Laboratory; Antropov, Vladimir [Ames Laboratory; Wang, Cai-Zhuang [Ames Laboratory; Kramer, Matthew J [Ames Laboratory; Long, Christian [University of Maryland; Takeuchi, Ichiro [University of Maryland

    2014-09-15T23:59:59.000Z

    Advanced materials characterization techniques with ever-growing data acquisition speed and storage capabilities represent a challenge in modern materials science, and new procedures to quickly assess and analyze the data are needed. Machine learning approaches are effective in reducing the complexity of data and rapidly homing in on the underlying trend in multi-dimensional data. Here, we show that by employing an algorithm called the mean shift theory to a large amount of diffraction data in high-throughput experimentation, one can streamline the process of delineating the structural evolution across compositional variations mapped on combinatorial libraries with minimal computational cost. Data collected at a synchrotron beamline are analyzed on the fly, and by integrating experimental data with the inorganic crystal structure database (ICSD), we can substantially enhance the accuracy in classifying the structural phases across ternary phase spaces. We have used this approach to identify a novel magnetic phase with enhanced magnetic anisotropy which is a candidate for rare-earth free permanent magnet.

  12. High-Throughput Program for the Discovery of NOx Reduction Catalysts |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeatMulti-Dimensional Subject:Ground HawaiiWaste Heat Recovery: Successa High

  13. High-Throughput Methodology for Discovery of Metal-Organic Frameworks with

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeatMulti-Dimensional Subject:Ground HawaiiWaste Heat Recovery: Successa High Binding

  14. High-Throughput Genetic Analysis and Combinatorial Chiral Separations Based on Capillary Electrophoresis

    SciTech Connect (OSTI)

    Wenwan Zhong

    2003-08-05T23:59:59.000Z

    Capillary electrophoresis (CE) offers many advantages over conventional analytical methods, such as speed, simplicity, high resolution, low cost, and small sample consumption, especially for the separation of enantiomers. However, chiral method developments still can be time consuming and tedious. They designed a comprehensive enantioseparation protocol employing neutral and sulfated cyclodextrins as chiral selectors for common basic, neutral, and acidic compounds with a 96-capillary array system. By using only four judiciously chosen separation buffers, successful enantioseparations were achieved for 49 out of 54 test compounds spanning a large variety of pKs and structures. Therefore, unknown compounds can be screened in this manner to identify optimal enantioselective conditions in just one rn. In addition to superior separation efficiency for small molecules, CE is also the most powerful technique for DNA separations. Using the same multiplexed capillary system with UV absorption detection, the sequence of a short DNA template can be acquired without any dye-labels. Two internal standards were utilized to adjust the migration time variations among capillaries, so that the four electropherograms for the A, T, C, G Sanger reactions can be aligned and base calling can be completed with a high level of confidence. the CE separation of DNA can be applied to study differential gene expression as well. Combined with pattern recognition techniques, small variations among electropherograms obtained by the separation of cDNA fragments produced from the total RNA samples of different human tissues can be revealed. These variations reflect the differences in total RNA expression among tissues. Thus, this Ce-based approach can serve as an alternative to the DNA array techniques in gene expression analysis.

  15. An Innovative High-Temperature High-Pressure Measurement While Drilling (MWD) Tool

    SciTech Connect (OSTI)

    Brian Boling

    2007-06-01T23:59:59.000Z

    Measurement while drilling (MWD) tools specified to 150 C (302 F) that provide wellbore surveys, real-time inclination, and natural gamma ray detection are a commodity item in the oilfield services industry. MWD tools specified to 175 C (347 F) that routinely demonstrate highly reliable operation are available from only a few service companies. Commercial MWD tools that reliably operate to 200 C (392 F) for extended periods of time and offer features like real-time gamma ray, retrievability, and reseatability are nonexistent. Need for these higher temperature tools will increase as wells become hotter in the search for new oil and gas resources. The goal of this project was to design a retrievable and reseatable high-pressure/high-temperature MWD tool with real-time continuous inclination, vibration detection, annular pressure, and gamma ray detection. This report describes the development of such a tool from concept, through feasibility, and into field testing and preliminary development planning. It describes the challenges encountered in the design of the tool, along with testing results and decisions about the commercial viability of the tool in the configuration in which it was developed. The decision was made not to commercialize the tool developed under this project because of a combination of battery technology problems and modulation power consumption at the required depths.

  16. Robofurnace: A semi-automated laboratory chemical vapor deposition system for high-throughput nanomaterial synthesis and process discovery

    SciTech Connect (OSTI)

    Oliver, C. Ryan; Westrick, William; Koehler, Jeremy; Brieland-Shoultz, Anna; Anagnostopoulos-Politis, Ilias; Cruz-Gonzalez, Tizoc [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States)] [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Hart, A. John, E-mail: ajhart@mit.edu [Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109 (United States); Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

    2013-11-15T23:59:59.000Z

    Laboratory research and development on new materials, such as nanostructured thin films, often utilizes manual equipment such as tube furnaces due to its relatively low cost and ease of setup. However, these systems can be prone to inconsistent outcomes due to variations in standard operating procedures and limitations in performance such as heating and cooling rates restrict the parameter space that can be explored. Perhaps more importantly, maximization of research throughput and the successful and efficient translation of materials processing knowledge to production-scale systems, relies on the attainment of consistent outcomes. In response to this need, we present a semi-automated lab-scale chemical vapor deposition (CVD) furnace system, called Robofurnace. Robofurnace is an automated CVD system built around a standard tube furnace, which automates sample insertion and removal and uses motion of the furnace to achieve rapid heating and cooling. The system has a 10-sample magazine and motorized transfer arm, which isolates the samples from the lab atmosphere and enables highly repeatable placement of the sample within the tube. The system is designed to enable continuous operation of the CVD reactor, with asynchronous loading/unloading of samples. To demonstrate its performance, Robofurnace is used to develop a rapid CVD recipe for carbon nanotube (CNT) forest growth, achieving a 10-fold improvement in CNT forest mass density compared to a benchmark recipe using a manual tube furnace. In the long run, multiple systems like Robofurnace may be linked to share data among laboratories by methods such as Twitter. Our hope is Robofurnace and like automation will enable machine learning to optimize and discover relationships in complex material synthesis processes.

  17. High Throughput Sample Preparation and Analysis for DNA Sequencing, PCR and Combinatorial Screening of Catalysis Based on Capillary Array Technique

    SciTech Connect (OSTI)

    Yonghua Zhang

    2002-05-27T23:59:59.000Z

    Sample preparation has been one of the major bottlenecks for many high throughput analyses. The purpose of this research was to develop new sample preparation and integration approach for DNA sequencing, PCR based DNA analysis and combinatorial screening of homogeneous catalysis based on multiplexed capillary electrophoresis with laser induced fluorescence or imaging UV absorption detection. The author first introduced a method to integrate the front-end tasks to DNA capillary-array sequencers. protocols for directly sequencing the plasmids from a single bacterial colony in fused-silica capillaries were developed. After the colony was picked, lysis was accomplished in situ in the plastic sample tube using either a thermocycler or heating block. Upon heating, the plasmids were released while chromsomal DNA and membrane proteins were denatured and precipitated to the bottom of the tube. After adding enzyme and Sanger reagents, the resulting solution was aspirated into the reaction capillaries by a syringe pump, and cycle sequencing was initiated. No deleterious effect upon the reaction efficiency, the on-line purification system, or the capillary electrophoresis separation was observed, even though the crude lysate was used as the template. Multiplexed on-line DNA sequencing data from 8 parallel channels allowed base calling up to 620 bp with an accuracy of 98%. The entire system can be automatically regenerated for repeated operation. For PCR based DNA analysis, they demonstrated that capillary electrophoresis with UV detection can be used for DNA analysis starting from clinical sample without purification. After PCR reaction using cheek cell, blood or HIV-1 gag DNA, the reaction mixtures was injected into the capillary either on-line or off-line by base stacking. The protocol was also applied to capillary array electrophoresis. The use of cheaper detection, and the elimination of purification of DNA sample before or after PCR reaction, will make this approach an attractive alternative to current methods for genetic analysis and disease diagnosis.

  18. High Content Image Analysis Identifies Novel Regulators of Synaptogenesis in a High-Throughput RNAi Screen of Primary Neurons

    E-Print Network [OSTI]

    Nieland, Thomas J.

    The formation of synapses, the specialized points of chemical communication between neurons, is a highly regulated developmental process fundamental to establishing normal brain circuitry. Perturbations of synapse formation ...

  19. Beyond differential expression : methods and tools for mining the transcriptomic landscape of human tissue and disease

    E-Print Network [OSTI]

    Schmid, Patrick R. (Patrick Raphael)

    2012-01-01T23:59:59.000Z

    Although there are a variety of high-throughput technologies used to perform biological experiments, DNA microarrays have become a standard tool in the modern biologist's arsenal. Microarray experiments provide measurements ...

  20. Miniaturized Analytical Platforms From Nanoparticle Components: Studies in the Construction, Characterization, and High-Throughput Usage of These Novel Architectures

    SciTech Connect (OSTI)

    Andrew David Pris

    2003-08-05T23:59:59.000Z

    The scientific community has recently experienced an overall effort to reduce the physical size of many experimental components to the nanometer size range. This size is unique as the characteristics of this regime involve aspects of pure physics, biology, and chemistry. One extensively studied example of a nanometer sized experimental component, which acts as a junction between these three principle scientific theologies, is deoxyribonucleic acid (DNA) or ribonucleic acid (RNA). These biopolymers not only contain the biological genetic guide to code for the production of life-sustaining materials, but are also being probed by physicists as a means to create electrical circuits and furthermore as controllable architectural and sensor motifs in the chemical disciplines. Possibly the most common nano-sized component between these sciences are nanoparticles composed of a variety of materials. The cross discipline employment of nanoparticles is evident from the vast amount of literature that has been produced from each of the individual communities within the last decade. Along these cross-discipline lines, this dissertation examines the use of several different types of nanoparticles with a wide array of surface chemistries to understand their adsorption properties and to construct unique miniaturized analytical and immunoassay platforms. This introduction will act as a literature review to provide key information regarding the synthesis and surface chemistries of several types of nanoparticles. This material will set the stage for a discussion of assembling ordered arrays of nanoparticles into functional platforms, architectures, and sensors. The introduction will also include a short explanation of the atomic force microscope that is used throughout the thesis to characterize the nanoparticle-based structures. Following the Introduction, four research chapters are presented as separate manuscripts. Chapter 1 examines the self-assembly of polymeric nanoparticles exhibiting a variety of surface chemistries and attempts to deconvolute general adsorption rules for their assembly on various substrates. Chapter 2 extends the usage of self-assembly of polymeric nanoparticles through a layer-by-layer deposition concept and photolithography methodologies to create analytical platforms with a vertical height controlled within the nanometer regime. This platform is then furthered in Chapter 3 by employing this integrated concept as a bio-recognition platform, with the extension of the method to a high-throughput screening system explored. Chapter 4 exploits two different types of nanoparticles, silica and gold, as multiplexed, self-assembled immunoassay sensors. This final research chapter is followed by a general summation and future prospectus section that concludes the dissertation.

  1. Nanocoatings for High-Efficiency Industrial Hydraulic and Tooling Systems

    SciTech Connect (OSTI)

    Clifton B. Higdon III

    2011-01-07T23:59:59.000Z

    Industrial manufacturing in the U.S. accounts for roughly one third of the 98 quadrillion Btu total energy consumption. Motor system losses amount to 1.3 quadrillion Btu, which represents the largest proportional loss of any end-use category, while pumps alone represent over 574 trillion BTU (TBTU) of energy loss each year. The efficiency of machines with moving components is a function of the amount of energy lost to heat because of friction between contacting surfaces. The friction between these interfaces also contributes to downtime and the loss of productivity through component wear and subsequent repair. The production of new replacement parts requires additional energy. Among efforts to reduce energy losses, wear-resistant, low-friction coatings on rotating and sliding components offer a promising approach that is fully compatible with existing equipment and processes. In addition to lubrication, one of the most desirable solutions is to apply a protective coating or surface treatment to rotating or sliding components to reduce their friction coefficients, thereby leading to reduced wear. Historically, a number of materials such as diamond-like carbon (DLC), titanium nitride (TiN), titanium aluminum nitride (TiAlN), and tungsten carbide (WC) have been examined as tribological coatings. The primary objective of this project was the development of a variety of thin film nanocoatings, derived from the AlMgB14 system, with a focus on reducing wear and friction in both industrial hydraulics and cutting tool applications. Proof-of-concept studies leading up to this project had shown that the constituent phases, AlMgB14 and TiB2, were capable of producing low-friction coatings by pulsed laser deposition. These coatings combine high hardness with a low friction coefficient, and were shown to substantially reduce wear in laboratory tribology tests. Selection of the two applications was based largely on the concept of improved mechanical interface efficiencies for energy conservation. In mobile hydraulic systems, efficiency gains through low friction would translate into improved fuel economy and fewer greenhouse gas emissions. Stationary hydraulic systems, accordingly, would consume less electrical power. Reduced tooling wear in machining operations would translate to greater operating yields, while lowering the energy consumed during processing. The AlMgB14 nanocoatings technology progressed beyond baseline laboratory tests into measurable energy savings and enhancements to product durability. Three key hydraulic markets were identified over the course of the project that will benefit from implementation: industrial vane pumps, orbiting valve-in-star hydraulic motors, and variable displacement piston pumps. In the vane pump application, the overall product efficiency was improved by as much as 11%. Similar results were observed with the hydraulic motors tested, where efficiency gains of over 10% were noted. For variable displacement piston pumps, overall efficiency was improved by 5%. For cutting tools, the most significant gains in productivity (and, accordingly, the efficiency of the machining process as a whole) were associated with the roughing and finishing of titanium components for aerospace systems. Use of the AlMgB14 nanocoating in customer field tests has shown that the coated tools were able to withstand machining rates as high as 500sfm (limited only by the substrate material), with relatively low flank wear when compared to other industrial offerings. AlMgB14 coated tools exhibited a 60% improvement over similarly applied TiAlN thin films. Furthermore, AlMgB14-based coatings in these particular tests lasted twice as long than their TiAlN counterparts at the 500sfm feed rates. Full implementation of the technology into the industrial hydraulic and cutting tool markets equates to a worldwide energy savings of 46 trillion BTU/year by 2030. U.S.-based GHG emissions associated with the markets identified would fall accordingly, dropping by as much as 50,000 tonnes annually.

  2. Structural and Aerodynamic Interaction Computational Tool for Highly Reconfigurable Wings

    E-Print Network [OSTI]

    Eisenbeis, Brian Joseph

    2011-10-21T23:59:59.000Z

    of the aerospace industry, and a reconfigurable wing is a significant element of a morphing aircraft. This thesis develops two tools for analyzing wing configurations with multiple geometric degrees-of-freedom: the structural tool and the aerodynamic and structural...

  3. High-Tech Tools for Teaching Physics: the Physics Education Technology Project

    E-Print Network [OSTI]

    Colorado at Boulder, University of

    MS #06-020 High-Tech Tools for Teaching Physics: the Physics Education Technology Project Noah Teaching and Learning September 15, 2006 #12;MS #06-020 High-Tech Tools for Teaching Physics: the Physics the Physics Education Technology (PhET) project, identifies features of these educational tools

  4. HiTSEE: A Visualization Tool for Hit Selection and Analysis in High-Throughput Screening Experiments

    E-Print Network [OSTI]

    Deussen, Oliver

    importantly the lack of temporal control required to study dynamic processes, since a protein cannot be turned a cellular system and to elucidate the function of proteins. As genes encode proteins, gene function can be modu- lated through a mutation, which in turn perturbs the function of the protein of interest

  5. Development of new tools and applications for high-throughput sequencing of microbiomes in environmental or clinical samples

    E-Print Network [OSTI]

    Blackburn, Matthew Christopher

    2010-01-01T23:59:59.000Z

    Novel sequencing technologies are rapidly advancing studies of microbial community structure and diversity. Sequencing platforms like the Illumina Genome Analyzer II (GAI1) and the Applied Biosystems SOLiD enable experiments ...

  6. High-Temperature Downhole Tools | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data CenterFranconia, Virginia: Energy Resources Jump to: navigation,Ohio:GreerHi Gtel Jump to: navigation,Solar Power PlantWellsNationalTools 2

  7. Nanocoatings for High-Efficiency Industrial and Tooling Systems

    SciTech Connect (OSTI)

    Blau, P; Qu, J.; Higdon, C. (Eaton Corporation)

    2011-02-01T23:59:59.000Z

    This industry-driven project was the result of a successful response by Eaton Corporation to a DOE/ITP Program industry call. It consisted of three phases in which ORNL participated. In addition to Eaton Corporation and ORNL (CRADA), the project team included Ames Laboratory, who developed the underlying concept for aluminum-magnesium-boron based nanocomposite coatings [1], and Greenleaf, a small tooling manufacturer in western Pennsylvania. This report focuses on the portion of this work that was conducted by ORNL in a CRADA with Eaton Corporation. A comprehensive final report for the entire effort, which ended in September 2010, has been prepared by Eaton Corporation. Phase I, Proof of Concept ran for one year (September 1, 2006 to September 30, 2007) during which the applicability of AlMgB14 single-phase and nanocomposite coatings on hydraulic material coupons and components as well as on tool inserts was demonstrated.. The coating processes used either plasma laser deposition (PLD) or physical vapor deposition (PVD). During Phase I, ORNL conducted laboratory-scale pin-on-disk and reciprocating pin-on-flat tests of coatings produced by PLD and PVD. Non-coated M2 tool steel was used as a baseline for comparison, and the material for the sliding counterface was Type 52100 bearing steel since it simulated the pump materials. Initial tests were run mainly in a commercial hydraulic fluid named Mobil DTE-24, but some tests were later run in a water-glycol mixture as well. A tribosystem analysis was conducted to define the operating conditions of pump components and to help develop simulative tests in Phase II. Phase II, Coating Process Scale-up was intended to use scaled-up process to generate prototype parts. This involved both PLD practices at Ames Lab, and a PVD scale-up study at Eaton using its production capable equipment. There was also a limited scale-up study at Greenleaf for the tooling application. ORNL continued to conduct friction and wear tests on process variants and developed tests to better simulate the applications of interest. ORNL also employed existing lubrication models to better understand hydraulic pump frictional behavior and test results. Phase III, Functional Testing focused on finalizing the strategy for commercialization of AlMgB14 coatings for both hydraulic and tooling systems. ORNL continued to provide tribology testing and analysis support for hydraulic pump applications. It included both laboratory-scale coupon testing and the analysis of friction and wear data from full component-level tests performed at Eaton Corp. Laboratory-scale tribology test methods are used to characterize the behavior of nanocomposite coatings prior to running them in full-sized hydraulic pumps. This task also includes developing tribosystems analyses, both to provide a better understanding of the performance of coated surfaces in alternate hydraulic fluids, and to help design useful laboratory protocols. Analysis also includes modeling the lubrication conditions and identifying the physical processes by which wear and friction of the contact interface changes over time. This final report summarizes ORNLs portion of the nanocomposite coatings development effort and presents both generated data and the analyses that were used in the course of this effort.

  8. Six-flow operations for catalyst development in Fischer-Tropsch synthesis: Bridging the gap between high-throughput experimentation and extensive product evaluation

    SciTech Connect (OSTI)

    Sartipi, Sina, E-mail: S.Sartipi@tudelft.nl, E-mail: J.Gascon@tudelft.nl; Jansma, Harrie; Bosma, Duco; Boshuizen, Bart; Makkee, Michiel; Gascon, Jorge, E-mail: S.Sartipi@tudelft.nl, E-mail: J.Gascon@tudelft.nl; Kapteijn, Freek [Department of Chemical Engineering, Catalysis Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft (Netherlands)] [Department of Chemical Engineering, Catalysis Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft (Netherlands)

    2013-12-15T23:59:59.000Z

    Design and operation of a six-flow fixed-bed microreactor setup for Fischer-Tropsch synthesis (FTS) is described. The unit consists of feed and mixing, flow division, reaction, separation, and analysis sections. The reactor system is made of five heating blocks with individual temperature controllers, assuring an identical isothermal zone of at least 10 cm along six fixed-bed microreactor inserts (4?mm inner diameter). Such a lab-scale setup allows running six experiments in parallel, under equal feed composition, reaction temperature, and conditions of separation and analysis equipment. It permits separate collection of wax and liquid samples (from each flow line), allowing operation with high productivities of C5+ hydrocarbons. The latter is crucial for a complete understanding of FTS product compositions and will represent an advantage over high-throughput setups with more than ten flows where such instrumental considerations lead to elevated equipment volume, cost, and operation complexity. The identical performance (of the six flows) under similar reaction conditions was assured by testing a same catalyst batch, loaded in all microreactors.

  9. CometChip: A High-throughput 96-Well Platform for Measuring DNA Damage in Microarrayed Human Cells

    E-Print Network [OSTI]

    Ge, Jing

    DNA damaging agents can promote aging, disease and cancer and they are ubiquitous in the environment and produced within human cells as normal cellular metabolites. Ironically, at high doses DNA damaging agents are also ...

  10. High power laser workover and completion tools and systems

    DOE Patents [OSTI]

    Zediker, Mark S; Rinzler, Charles C; Faircloth, Brian O; Koblick, Yeshaya; Moxley, Joel F

    2014-10-28T23:59:59.000Z

    Workover and completion systems, devices and methods for utilizing 10 kW or more laser energy transmitted deep into the earth with the suppression of associated nonlinear phenomena. Systems and devices for the laser workover and completion of a borehole in the earth. These systems and devices can deliver high power laser energy down a deep borehole, while maintaining the high power to perform laser workover and completion operations in such boreholes deep within the earth.

  11. Nanograined half-Heusler semiconductors as advanced thermoelectrics: an ab-initio high-throughput statistical study

    E-Print Network [OSTI]

    Curtarolo, Stefano

    the thermoelectric effect to scavenge electric power from waste heat has long been an attractive route in the pursuit of sustainable en- ergy generation.1 Despite recent progress, the goal of producing efficient thermoelectricNanograined half-Heusler semiconductors as advanced thermoelectrics: an ab-initio high

  12. Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods

    SciTech Connect (OSTI)

    Lewis, Amanda; Zhao, Hongbin; Hopkins, Scott

    2014-09-30T23:59:59.000Z

    This report summarizes the work completed under the U.S. Department of Energy Project Award No.: DE-FE0001181 titled Designing and Validating Ternary Pd Alloys for Optimum Sulfur/Carbon Resistance in Hydrogen Separation and Carbon Capture Membrane Systems Using High-Throughput Combinatorial Methods. The project started in October 1, 2009 and was finished September 30, 2014. Pall Corporation worked with Cornell University to sputter and test palladium-based ternary alloys onto silicon wafers to examine many alloys at once. With the specialized equipment at Georgia Institute of Technology that analyzed the wafers for adsorbed carbon and sulfur species six compositions were identified to have resistance to carbon and sulfur species. These compositions were deposited on Pall AccuSep supports by Colorado School of Mines and then tested in simulated synthetic coal gas at the Pall Corporation. Two of the six alloys were chosen for further investigations based on their performance. Alloy reproducibility and long-term testing of PdAuAg and PdZrAu provided insight to the ability to manufacture these compositions for testing. PdAuAg is the most promising alloy found in this work based on the fabrication reproducibility and resistance to carbon and sulfur. Although PdZrAu had great initial resistance to carbon and sulfur species, the alloy composition has a very narrow range that hindered testing reproducibility.

  13. High bandwidth rotary fast tool servos and a hybrid rotary/linear electromagnetic actuator

    E-Print Network [OSTI]

    Montesanti, Richard Clement

    2005-01-01T23:59:59.000Z

    This thesis describes the development of two high bandwidth short-stroke rotary fast tool servos and the hybrid rotary/linear electromagnetic actuator developed for one of them. Design insights, trade-off methodologies, ...

  14. High Energy Colliders as Tools to Understand the Early Universe

    SciTech Connect (OSTI)

    Tait, Tim (ANL) [ANL

    2008-08-16T23:59:59.000Z

    Cosmological observations have reached a new era of precision, and reveal many interesting and puzzling features of the Universe. I will briefly review two of the most exciting mysteries: the nature of the dark components of the Universe, and the origin of the asymmetry between matter and anti-matter. I will argue that our best hope of unraveling these questions will need to combine information from the heavens with measurements in the lab at high energy particle accelerators. The end of run II of the Tevatron, the up-coming Large Hadron Collider and proposed International Linear Collider all have great potential to help us answer these questions in the near future.

  15. Improved Modeling Tools Development for High Penetration Solar

    SciTech Connect (OSTI)

    Washom, Byron

    2014-12-11T23:59:59.000Z

    One of the significant objectives of the High Penetration solar research is to help the DOE understand, anticipate, and minimize grid operation impacts as more solar resources are added to the electric power system. For Task 2.2, an effective, reliable approach to predicting solar energy availability for energy generation forecasts using the University of California, San Diego (UCSD) Sky Imager technology has been demonstrated. Granular cloud and ramp forecasts for the next 5 to 20 minutes over an area of 10 square miles were developed. Sky images taken every 30 seconds are processed to determine cloud locations and cloud motion vectors yielding future cloud shadow locations respective to distributed generation or utility solar power plants in the area. The performance of the method depends on cloud characteristics. On days with more advective cloud conditions, the developed method outperforms persistence forecasts by up to 30% (based on mean absolute error). On days with dynamic conditions, the method performs worse than persistence. Sky Imagers hold promise for ramp forecasting and ramp mitigation in conjunction with inverter controls and energy storage. The pre-commercial Sky Imager solar forecasting algorithm was documented with licensing information and was a Sunshot website highlight

  16. High throughput reproducible cantilever functionalization

    DOE Patents [OSTI]

    Evans, Barbara R; Lee, Ida

    2014-01-21T23:59:59.000Z

    A method for functionalizing cantilevers is provided that includes providing a holder having a plurality of channels each having a width for accepting a cantilever probe and a plurality of probes. A plurality of cantilever probes are fastened to the plurality of channels of the holder by the spring clips. The wells of a well plate are filled with a functionalization solution, wherein adjacent wells in the well plate are separated by a dimension that is substantially equal to a dimension separating adjacent channels of the plurality of channels. Each cantilever probe that is fastened within the plurality of channels of the holder is applied to the functionalization solution that is contained in the wells of the well plate.

  17. High-Throughput Plasmonic Nanolithography

    E-Print Network [OSTI]

    Pan, Liang

    2010-01-01T23:59:59.000Z

    by a thin layer of Perfluoropolyether (PFPE) as a lubricant2-nm thick lubricant Perfluoropolyether (PFPE) was also dip-

  18. High-throughput Process Development

    E-Print Network [OSTI]

    Lebendiker, Mario

    .2 Screening experiments in PreDictor plates vs small-scale columns....................................5 1 Chromatography Principles and Methods 18-1022-29 Antibody Purification Handbook 18-1037-46 Ion Exchange Protein Purification Handbook Principles and Methods 18-1142-75 Protein Purification Handbook 18

  19. Driving Down HB-LED Costs: Implementation of Process Simulation Tools and Temperature Control Methods of High Yield MOCVD Growth

    SciTech Connect (OSTI)

    William Quinn

    2012-04-30T23:59:59.000Z

    The overall objective of this multi-faceted program is to develop epitaxial growth systems that meet a goal of 75% (4X) cost reduction in the epitaxy phase of HB-LED manufacture. A 75% reduction in yielded epitaxy cost is necessary in order to achieve the cost goals for widespread penetration of HB-LED??s into back-lighting units (BLU) for LCD panels and ultimately for solid-state lighting (SSL). To do this, the program will address significant improvements in overall equipment Cost of Ownership, or CoO. CoO is a model that includes all costs associated with the epitaxy portion of production. These aspects include cost of yield, capital cost, operational costs, and maintenance costs. We divide the program into three phases where later phases will incorporate the gains of prior phases. Phase one activities are enabling technologies. In collaboration with Sandia National Laboratories we develop a Fluent-compatible chemistry predictive model and a set of mid-infrared and near-ultraviolet pyrometer monitoring tools. Where previously the modeling of the reactor dynamics were studied within FLUENT alone, here, FLUENT and Chemkin are integrated into a comprehensive model of fluid dynamics and the most advanced transport equations developed for Chemkin. Specifically, the Chemkin model offered the key reaction terms for gas-phase nucleation, a key consideration in the optimization of the MOCVD process. This new predictive model is used to design new MOCVD reactors with optimized growth conditions and the newly developed pyrometers are used monitor and control the MOCVD process temperature to within 0.5°C run-to-run and within each wafer. This portion of the grant is in collaboration with partners at Sandia National Laboratories. Phase two activities are continuous improvement projects which extend the current reactor platform along the lines of improved operational efficiency, improved systems control for throughput, and carrier modifications for increased yield. Programmatically, improvements made in Phase I are applied to developments of Phase II when applicable. Phase three is the culmination of the individual tasks from both phases one and two applied to proposed production platforms. We selectively combine previously demonstrated tasks and other options to develop a high-volume production-worthy MOCVD system demonstrating >3x throughput, 1.3x capital efficiency, and 0.7x cost of ownership. In a parallel demonstration we validate the concept of an improved, larger deposition system which utilizes the predictive modeling of chemistry-based flow analysis and extensions of the improvements demonstrated on the current platforms. This validation includes the build and testing of a prototype version of the hardware and demonstration of 69% reduction in the cost of ownership. Also, in this phase we present a stand-alone project to develop a high-temperature system which improves source efficiency by 30% while concurrently increasing growth rate by 1.3x. The material quality is held to the same material quality specifications of our existing baseline processes. The merits of other line item tasks in phase three are discussed for inclusion on next-generation platforms.

  20. Unsteady, high Reynolds number validation cases for a multi-phase CFD analysis tool have been

    E-Print Network [OSTI]

    Kunz, Robert Francis

    and constituent volume fraction transport/generation for liquid, condensable vapor and non-condensable gas fields1 Abstract Unsteady, high Reynolds number validation cases for a multi-phase CFD analysis tool have of the effect of cavitation number, Reynolds number and turbulence model has been made. Analysis of the modeled

  1. www.emsl.pnnl.gov New Decade, New Tools, New Science: SyStemS biology

    E-Print Network [OSTI]

    , including high-throughput genomics, transcriptomics, proteomics, and metabolomics analyses as well as high

  2. CgWind: A high-order accurate simulation tool for wind turbines and wind farms

    SciTech Connect (OSTI)

    Chand, K K; Henshaw, W D; Lundquist, K A; Singer, M A

    2010-02-22T23:59:59.000Z

    CgWind is a high-fidelity large eddy simulation (LES) tool designed to meet the modeling needs of wind turbine and wind park engineers. This tool combines several advanced computational technologies in order to model accurately the complex and dynamic nature of wind energy applications. The composite grid approach provides high-quality structured grids for the efficient implementation of high-order accurate discretizations of the incompressible Navier-Stokes equations. Composite grids also provide a natural mechanism for modeling bodies in relative motion and complex geometry. Advanced algorithms such as matrix-free multigrid, compact discretizations and approximate factorization will allow CgWind to perform highly resolved calculations efficiently on a wide class of computing resources. Also in development are nonlinear LES subgrid-scale models required to simulate the many interacting scales present in large wind turbine applications. This paper outlines our approach, the current status of CgWind and future development plans.

  3. SOWFA Super-Controller: A High-Fidelity Tool for Evaluating Wind Plant Control Approaches

    SciTech Connect (OSTI)

    Fleming, P.; Gebraad, P.; van Wingerden, J. W.; Lee, S.; Churchfield, M.; Scholbrock, A.; Michalakes, J.; Johnson, K.; Moriarty, P.

    2013-01-01T23:59:59.000Z

    This paper presents a new tool for testing wind plant controllers in the Simulator for Offshore Wind Farm Applications (SOWFA). SOWFA is a high-fidelity simulator for the interaction between wind turbine dynamics and the fluid flow in a wind plant. The new super-controller testing environment in SOWFA allows for the implementation of the majority of the wind plant control strategies proposed in the literature.

  4. Evaluation of servo, geometric and dynamic error sources on five axis high-speed machine tool

    E-Print Network [OSTI]

    Andolfatto, Loc; Mayer, Ren

    2011-01-01T23:59:59.000Z

    Many sources of errors exist in the manufacturing process of complex shapes. Some approximations occur at each step from the design geometry to the machined part. The aim of the paper is to present a method to evaluate the effect of high speed and high dynamic load on volumetric errors at the tool center point. The interpolator output signals and the machine encoder signals are recorded and compared to evaluate the contouring errors resulting from each axis follow-up error. The machine encoder signals are also compared to the actual tool center point position as recorded with a non-contact measuring instrument called CapBall to evaluate the total geometric errors. The novelty of the work lies in the method that is proposed to decompose the geometric errors in two categories: the quasi-static geometric errors independent from the speed of the trajectory and the dynamic geometric errors, dependent on the programmed feed rate and resulting from the machine structure deflection during the acceleration of its axes...

  5. A High Performance Computing Platform for Performing High-Volume Studies With Windows-based Power Grid Tools

    SciTech Connect (OSTI)

    Chen, Yousu; Huang, Zhenyu

    2014-08-31T23:59:59.000Z

    Serial Windows-based programs are widely used in power utilities. For applications that require high volume simulations, the single CPU runtime can be on the order of days or weeks. The lengthy runtime, along with the availability of low cost hardware, is leading utilities to seriously consider High Performance Computing (HPC) techniques. However, the vast majority of the HPC computers are still Linux-based and many HPC applications have been custom developed external to the core simulation engine without consideration for ease of use. This has created a technical gap for applying HPC-based tools to todays power grid studies. To fill this gap and accelerate the acceptance and adoption of HPC for power grid applications, this paper presents a prototype of generic HPC platform for running Windows-based power grid programs on Linux-based HPC environment. The preliminary results show that the runtime can be reduced from weeks to hours to improve work efficiency.

  6. Development of a high-temperature diagnostics-while-drilling tool.

    SciTech Connect (OSTI)

    Chavira, David J.; Huey, David (Stress Engineering Services, Inc.); Hetmaniak, Chris (Stress Engineering Services, Inc.); Polsky, Yarom; King, Dennis K.; Jacobson, Ronald David; Blankenship, Douglas Alan; Knudsen, Steven Dell; Henfling, Joseph Anthony; Mansure, Arthur James

    2009-01-01T23:59:59.000Z

    The envisioned benefits of Diagnostics-While-Drilling (DWD) are based on the principle that high-speed, real-time information from the downhole environment will promote better control of the drilling process. Although in practice a DWD system could provide information related to any aspect of exploration and production of subsurface resources, the current DWD system provides data on drilling dynamics. This particular set of new tools provided by DWD will allow quicker detection of problems, reduce drilling flat-time and facilitate more efficient drilling (drilling optimization) with the overarching result of decreased drilling costs. In addition to providing the driller with an improved, real-time picture of the drilling conditions downhole, data generated from DWD systems provides researchers with valuable, high fidelity data sets necessary for developing and validating enhanced understanding of the drilling process. Toward this end, the availability of DWD creates a synergy with other Sandia Geothermal programs, such as the hard-rock bit program, where the introduction of alternative rock-reduction technologies are contingent on the reduction or elimination of damaging dynamic effects. More detailed descriptions of the rationale for the program and early development efforts are described in more detail by others [SAND2003-2069 and SAND2000-0239]. A first-generation low-temperature (LT) DWD system was fielded in a series of proof-of-concept tests (POC) to validate functionality. Using the LT system, DWD was subsequently used to support a single-laboratory/multiple-partner CRADA (Cooperative Research and Development Agreement) entitled Advanced Drag Bits for Hard-Rock Drilling. The drag-bit CRADA was established between Sandia and four bit companies, and involved testing of a PDC bit from each company [Wise, et al., 2003, 2004] in the same lithologic interval at the Gas Technology Institute (GTI) test facility near Catoosa, OK. In addition, the LT DWD system has been fielded in cost-sharing efforts with an industrial partner to support the development of new generation hard-rock drag bits. Following the demonstrated success of the POC DWD system, efforts were initiated in FY05 to design, fabricate and test a high-temperature (HT) capable version of the DWD system. The design temperature for the HT DWD system was 225 C. Programmatic requirements dictated that a HT DWD tool be developed during FY05 and that a working system be demonstrated before the end of FY05. During initial design discussions regarding a high-temperature system it was decided that, to the extent possible, the HT DWD system would maintain functionality similar to the low temperature system, that is, the HT DWD system would also be designed to provide the driller with real-time information on bit and bottom-hole-assembly (BHA) dynamics while drilling. Additionally, because of time and fiscal constraints associated with the HT system development, the design of the HT DWD tool would follow that of the LT tool. The downhole electronics package would be contained in a concentrically located pressure barrel and the use of externally applied strain gages with thru-tool connectors would also be used in the new design. Also, in order to maximize the potential wells available for the HT DWD system and to allow better comparison with the low-temperature design, the diameter of the tool was maintained at 7-inches. This report discusses the efforts associated with the development of a DWD system capable of sustained operation at 225 C. This report documents work performed in the second phase of the Diagnostics-While-Drilling (DWD) project in which a high-temperature (HT) version of the phase 1 low-temperature (LT) proof-of-concept (POC) DWD tool was built and tested. Descriptions of the design, fabrication and field testing of the HT tool are provided. Background on prior phases of the project can be found in SAND2003-2069 and SAND2000-0239.

  7. XGet: a highly scalable and efficient file transfer tool for clusters

    SciTech Connect (OSTI)

    Greenberg, Hugh [Los Alamos National Laboratory; Ionkov, Latchesar [Los Alamos National Laboratory; Minnich, Ronald [SNL

    2008-01-01T23:59:59.000Z

    As clusters rapidly grow in size, transferring files between nodes can no longer be solved by the traditional transfer utilities due to their inherent lack of scalability. In this paper, we describe a new file transfer utility called XGet, which was designed to address the scalability problem of standard tools. We compared XGet against four transfer tools: Bittorrent, Rsync, TFTP, and Udpcast and our results show that XGet's performance is superior to the these utilities in many cases.

  8. Final Project Report: Tools for the Development of High Performance Energy Applications and Systems

    SciTech Connect (OSTI)

    Hollingsworth, Jeff

    2014-10-22T23:59:59.000Z

    This project concentrated on various aspects of creating tool infrastructure to make it easier to program large-scale parallel computers. The research conducted during this project is summarized in this report. The complete details of the work are available in the ten publications listed at the end of the report. Many of the concepts created during this project have been incorporated into tools and made available as freely downloadable software (at www.dyninst.org). It also supported the Ph.D. studies of three students.

  9. Technology support for high-throughput processing of thin-film CdTe PV modules: Annual technical report, Phase 1, 1 April 1998--31 March 1999

    SciTech Connect (OSTI)

    Rose, D.H.; Powell, R.C.; Grecu, D.; Jayamaha, U.; Hanak, J.J.; Bohland, J.; Smigielski, K.; Dorer, G.L.

    1999-10-25T23:59:59.000Z

    This report describes work performed by First Solar, L.L.C., during Phase 1 of this 3-year subcontract. The research effort of this subcontract is divided into four areas: (1) process and equipment development, (2) efficiency improvement, (3) characterization and analysis, and (4) environmental, health, and safety. As part of the process development effort, the output of the pilot-production facility was increased. More than 6,200 8-ft{sup 2} CdS/CdTe plates were produced during Phase 1--more than double the total number produced prior to Phase 1. This increase in pilot-production rate was accomplished without a loss in the PV conversion efficiency: the average total-area AM1.5 efficiency of sub-modules produced during the reporting period was 6.4%. Several measurement techniques, such as large-area measurement of CdS thickness, were developed to aid process improvement, and the vapor-transport deposition method was refined. CdTe thickness uniformity and reproducibility were improved. From a population of more than 1,100 plates, the mean standard deviation within a plate was 7.3% and the standard deviation of individual-plate averages was 6.8%. As part of the efficiency-improvement task, research was done on devices with thin-CdS and buffer layers. A cell with 13.9% efficiency was produced on a high-quality substrate, and higher than 12% efficiency was achieved with a cell with no CdS layer. A number of experiments were performed as part of the characterization and analysis task. The temperature dependence of CdTe modules was investigated; the power output was found to be relatively insensitive (<5%) to temperature in the 25 to 50 C range. As part of the characterization and analysis task, considerable effort was also given to reliability verification and improvement. The most carefully monitored array, located at the NREL, was found to have unchanged power output within the margin of error of measurement (5%) after 5 years in the field. The first round of National CdTe Team stability tests were concluded. One back-contact formulation resulted in cells that increased in efficiency as a result of 9,700 hours of light soaking. As part of the environmental, health, and safety task, an emissions survey was performed for the pilot-production facility. For production of 360 modules/day, it was predicted that the cadmium emissions would be only 0.015% of the level that would require any permitting; however, methanol emissions may require permitting if anticipated process changes are not implemented. Process improvements in edge delete, CdS material preparation, waste compaction, CdCl{sub 2}-vapor collection, and wastewater treatment were made, resulting in reduced costs, reduced emissions, and improved operator safety.

  10. A high-throughput distributed DNA

    E-Print Network [OSTI]

    Weller, Jennifer Walsh

    of royalty provided that (1) each reproduction is done without alteration and (2) the Journal reference, of this paper may be copied or distributed royalty free without further permission by computer-based and other

  11. High-throughput hyperdimensional vertebrate phenotyping

    E-Print Network [OSTI]

    Pardo-Martin, Carlos

    Most gene mutations and biologically active molecules cause complex responses in animals that cannot be predicted by cell culture models. Yet animal studies remain too slow and their analyses are often limited to only a ...

  12. High Throughput Single Molecule Investigation of Transcription

    E-Print Network [OSTI]

    Kim, Soohong

    2012-01-01T23:59:59.000Z

    Dots. Nano Letters 9, 15981603. 4. Ebenstein, Y. , Gassman,Dots. Nano Letters 9, 1598-1603 (2009). Ebenstein, Y. ,

  13. High Throughput Single Molecule Investigation of Transcription

    E-Print Network [OSTI]

    Kim, Soohong

    2012-01-01T23:59:59.000Z

    Single Molecule Protein Folding in a Coaxial Mixer. Biophys.Kinetic Studies of Protein Folding. Anal. Chem. 76, 7169-Molecule Measurement of Protein Folding Kinetics . Science

  14. High throughput liquid absorption preconcentrator sampling instrument

    DOE Patents [OSTI]

    Zaromb, S.; Bozen, R.M.

    1992-12-22T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis. 12 figs.

  15. Optimal Assembly for High Throughput Shotgun Sequencing

    E-Print Network [OSTI]

    Bresler, Guy; Bresler, Ma'ayan; Tse, David

    2013-01-01T23:59:59.000Z

    suf- ficient conditions for success in terms of repeat-between the sufficient condition guaranteeing the success ofby a read). Condition (a) K > ? interleaved for success of

  16. DOE Workshop HIGH THROUGHPUT/COMBINATORIAL SCREENING

    E-Print Network [OSTI]

    Optimization: 2o Screening Lab Reactor Pilot Plant Plant Experiments per day Symyx Industry 1000's 100's 10's 1 · Parallel Reactor Technology · HT Polymer Characterization · Heterogeneous Catalysis · Substrate Synthesis · Catalyst Preparation · Parallel Reactor Technology · HT Product Characterization · Specialty Polymers

  17. High throughput solar cell ablation system

    DOE Patents [OSTI]

    Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John

    2012-09-11T23:59:59.000Z

    A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.

  18. High throughput solar cell ablation system

    DOE Patents [OSTI]

    Harley, Gabriel; Pass, Thomas; Cousins, Peter John; Viatella, John

    2014-10-14T23:59:59.000Z

    A solar cell is formed using a solar cell ablation system. The ablation system includes a single laser source and several laser scanners. The laser scanners include a master laser scanner, with the rest of the laser scanners being slaved to the master laser scanner. A laser beam from the laser source is split into several laser beams, with the laser beams being scanned onto corresponding wafers using the laser scanners in accordance with one or more patterns. The laser beams may be scanned on the wafers using the same or different power levels of the laser source.

  19. High-throughput proteomics : optical approaches.

    SciTech Connect (OSTI)

    Davidson, George S.

    2008-09-01T23:59:59.000Z

    Realistic cell models could greatly accelerate our ability to engineer biochemical pathways and the production of valuable organic products, which would be of great use in the development of biofuels, pharmaceuticals, and the crops for the next green revolution. However, this level of engineering will require a great deal more knowledge about the mechanisms of life than is currently available. In particular, we need to understand the interactome (which proteins interact) as it is situated in the three dimensional geometry of the cell (i.e., a situated interactome), and the regulation/dynamics of these interactions. Methods for optical proteomics have become available that allow the monitoring and even disruption/control of interacting proteins in living cells. Here, a range of these methods is reviewed with respect to their role in elucidating the interactome and the relevant spatial localizations. Development of these technologies and their integration into the core competencies of research organizations can position whole institutions and teams of researchers to lead in both the fundamental science and the engineering applications of cellular biology. That leadership could be particularly important with respect to problems of national urgency centered around security, biofuels, and healthcare.

  20. High Throughput Single Molecule Investigation of Transcription

    E-Print Network [OSTI]

    Kim, Soohong

    2012-01-01T23:59:59.000Z

    Squires, T. & Quake, S. Microfluidics: Fluid physics at themerged two techniques: microfluidics and single- moleculeassay equipped with microfluidics. Chapter three describes

  1. High-Throughput and Combinatorial Screening

    E-Print Network [OSTI]

    , for the United States Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL Hydride + H2 Complex Hydride Boride + Binary Hydride + H2 Metal Borohydride We can test six samples per vessel design complete ­ 15 sample hotplates, 3 gas detectors Achieve sample temperatures of 1200 K and H

  2. A High-Throughput Macromolecule Characterization System

    E-Print Network [OSTI]

    Kim, Jae Hyun

    2013-08-31T23:59:59.000Z

    stability of macromolecules in response to various environmental perturbations. Numerous proteins and macromolecular complexes have been analyzed by EPDs to summarize results from large data sets from multiple biophysical techniques. The current EPD method...

  3. Active wear and failure mechanisms of TiN-coated high speed steel and TiN-coated cemented carbide tools when machining powder metallurgically made stainless steels

    SciTech Connect (OSTI)

    Jiang, L.; Haenninen, H.; Paro, J.; Kauppinen, V. [Helsinki Univ. of Technology, Espoo (Finland)

    1996-09-01T23:59:59.000Z

    In this study, active wear and failure mechanisms of both TiN-coated high speed steel and TiN-coated cemented carbide tools when machining stainless steels made by powder metallurgy in low and high cutting speed ranges, respectively, have been investigated. Abrasive wear mechanisms, fatigue-induced failure, and adhesive and diffusion wear mechanisms mainly affected the tool life of TiN-coated high speed steel tools at cutting speeds below 35 m/min, between 35 and 45 m/min, and over 45 m/min, respectively. Additionally, fatigue-induced failure was active at cutting speeds over 45 m/min in the low cutting speed range when machining powder metallurgically made duplex stainless steel 2205 and austenitic stainless steel 316L. In the high cutting speed range, from 100 to 250 m/min, fatigue-induced failure together with diffusion wear mechanism, affected the tool life of TiN-coated cemented carbide tools when machining both 316L and 2205 stainless steels. It was noticed that the tool life of TiN-coated high speed steel tools used in the low cutting speed range when machining 2205 steel was longer than that when machining 316L steel, whereas the tool life of TiN-coated cemented carbide tools used in the high cutting speed range when machining 316L steel was longer than that when machining 2205 steel.

  4. Conformance Tool High Level Design Document: IEC 61850 Cyber Security Acceleration Project

    SciTech Connect (OSTI)

    Edgar, Thomas W.

    2013-05-01T23:59:59.000Z

    This document is the high level design document for the Pacific Northwest National Laboratory (PNNL) IEC 62351-3, 4 and 6 standards conformance test software toolkit.

  5. High Temperature Tools and Sensors, Down-hole Pumps and Drilling |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeatMulti-Dimensional Subject:Ground Hawaii HIGH PERFORMANCE andHigh

  6. High-tech tool predicts fire behavior in bark beetle-ravaged forests

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-SeriesFlickr FlickrGuidedCH2MLLC High-Rate, High-Capacityand

  7. High-resolution microcalorimeter detectors as a tool in the future of nuclear safeguards

    SciTech Connect (OSTI)

    Hoteling, Nathan J [Los Alamos National Laboratory; Hoover, Andrew S [Los Alamos National Laboratory

    2010-01-01T23:59:59.000Z

    New measurements are presented from the LANL-NIST microcalorimeter array for two standard plutonium sources. The results demonstrate substantially smaller error bars obtained from the spectral analysis program FRAM. Some areas of improvement to the analysis technique have been identified, indicating that the micro calorimeter results can be improved upon. These results support the viability of a device for performing real nuclear safeguards measurements in the near future. The challenge of providing reliably accurate and precise data is a critical component of any safeguards initiative. In the realm of nuclear safeguards, this is an especially daunting task since inaccurate and/or imprecise data could have very serious international consequences. As such, there is a constant drive within the community to establish better measurement and analysis techniques in order to further reduce the associated errors and uncertainties. Even with todays state of the art equipment, measurement uncertainties can extend to several significant quantities worth of material over a relatively modest period of time. Furthermore, there is a strong desire for improved nondestructive analysis techniques in order to reduce both the cost, turnover rate, and inconvenience of destructive analyses. One promising new technology that may help to realize these goals is that of gamma-ray microcalorimeter detectors. The hallmark quality of this new technique is the ability to achieve energy resolution nearly an order of magnitude better than typical planar high-purity germanium (HPGe) detectors. Such an improvement may help reduce uncertainties associated with, for instance, plutonium isotopics or uranium enrichment measurements. This may, in turn, help to reduce uncertainties in total plutonium and/or uranium content in a given sample without the need for destructive analysis. In this paper, we will describe this new detector technology as well as some recent measurements carried out with the LANL-NIST gamma-ray microcalorimeter ({micro}cal) array. Discussion will focus on the capabilities of this technology as well as the progress toward a practical measurement device.

  8. New hydrocracking catalysts increase throughput, run length

    SciTech Connect (OSTI)

    Huizinga, T. [Shell Internationale Petroleum Mij., The Hague (Netherlands); Theunissen, J.M.H. [Rayong Refinery Co. Ltd., Rayong (Thailand); Minderhoud, H.; Veen, R. van [Koninklijke/Shell-Lab., Amsterdam (Netherlands)

    1995-06-26T23:59:59.000Z

    An improved, second-stage hydrocracking catalyst has been developed by combining stabilized Y zeolites with amorphous silica alumina cracking components. A commercial application of this catalyst, along with a new, first-stage zeolitic hydrocracking catalyst, resulted in increased unit throughput and cycle length. The paper discusses the hydrocracking process, first-stage catalysts, second-stage catalysts, hydrogenation process, commercial results, and product properties.

  9. Industrial Implementation of a Coordinator MPC for Maximizing Throughput at a

    E-Print Network [OSTI]

    Skogestad, Sigurd

    offshore fields. This set high demands, not only to the plant efficiency and its regularity, but alsoIndustrial Implementation of a Coordinator MPC for Maximizing Throughput at a Large-Scale Gas Plant°arstø gas plant is described. The "coordinator MPC" coordinates the flows through the network

  10. Percussion tool

    DOE Patents [OSTI]

    Reed, Teddy R.

    2006-11-28T23:59:59.000Z

    A percussion tool is described and which includes a housing mounting a tool bit; a reciprocally moveable hammer borne by the housing and which is operable to repeatedly strike the tool bit; and a reciprocally moveable piston enclosed within the hammer and which imparts reciprocal movement to the reciprocally moveable hammer.

  11. Veeco Develops Tools to Drive Down HBLED Costs

    Broader source: Energy.gov [DOE]

    Veeco is working in partnership with Sandia National Laboratories and Philips Lumileds to drive down the cost of high-brightness LEDs by implementing process simulation tools and by improving temperature measurement and control methods to increase MOCVD yield. Veeco is working with Sandia to reduce the cost of ownership (COO) of the deposition equipment by, for example, using a heated flow flange, which reduces the consumption of the expensive precursors (ammonia, nitrogen, hydrogen, and the metal organics) by 40 percent. Two different types of pyrometers developed by Sandia and Veeco are being tested by Philips Lumileds to control the substrate temperature, which helps determine the color of the LED. If all works according to plan, the COO will be reduced by at least 75 percent by improving throughput, growth uniformity, yield, and temperature stabilization.

  12. Simrank: Rapid and sensitive general-purpose k-mer search tool

    SciTech Connect (OSTI)

    DeSantis, T.Z.; Keller, K.; Karaoz, U.; Alekseyenko, A.V; Singh, N.N.S.; Brodie, E.L; Pei, Z.; Andersen, G.L; Larsen, N.

    2011-04-01T23:59:59.000Z

    Terabyte-scale collections of string-encoded data are expected from consortia efforts such as the Human Microbiome Project (http://nihroadmap.nih.gov/hmp). Intra- and inter-project data similarity searches are enabled by rapid k-mer matching strategies. Software applications for sequence database partitioning, guide tree estimation, molecular classification and alignment acceleration have benefited from embedded k-mer searches as sub-routines. However, a rapid, general-purpose, open-source, flexible, stand-alone k-mer tool has not been available. Here we present a stand-alone utility, Simrank, which allows users to rapidly identify database strings the most similar to query strings. Performance testing of Simrank and related tools against DNA, RNA, protein and human-languages found Simrank 10X to 928X faster depending on the dataset. Simrank provides molecular ecologists with a high-throughput, open source choice for comparing large sequence sets to find similarity.

  13. Streak Seeding Automation Using Silicon Tools CUCS-015-06

    E-Print Network [OSTI]

    Georgiev, Atanas

    diseases. Despite the recent impressive achievements in the high-throughput (HTP) protein crystallography solution by the modern HTP software. In pilot studies of Phase 1 of the Protein Structure Initiative (PSI

  14. Method and apparatus for maximizing throughput of indirectly heated rotary kilns

    DOE Patents [OSTI]

    Coates, Ralph L; Smoot, L. Douglas; Hatfield, Kent E

    2012-10-30T23:59:59.000Z

    An apparatus and method for achieving improved throughput capacity of indirectly heated rotary kilns used to produce pyrolysis products such as shale oils or coal oils that are susceptible to decomposition by high kiln wall temperatures is disclosed. High throughput is achieved by firing the kiln such that optimum wall temperatures are maintained beginning at the point where the materials enter the heating section of the kiln and extending to the point where the materials leave the heated section. Multiple high velocity burners are arranged such that combustion products directly impact on the area of the kiln wall covered internally by the solid material being heated. Firing rates for the burners are controlled to maintain optimum wall temperatures.

  15. Tests using the Globus "gsiftp" tool between Caltech and Argonne

    E-Print Network [OSTI]

    DRAFT Tests using the Globus "gsiftp" tool between Caltech and Argonne Julian Bunn, 16th December 1999 Introduction Measurements of throughput on the WAN from Caltech/CACR to Argonne/MCS were made/null on the Argonne machine. The CACR machine used was the 256-CPU Exemplar X- class "neptune

  16. Techniques and tools for measuring energy efficiency of scientific software applications

    E-Print Network [OSTI]

    Abdurachmanov, David; Eulisse, Giulio; Knight, Robert; Niemi, Tapio; Nurminen, Jukka K; Nyback, Filip; Pestana, Goncalo; Ou, Zhonghong; Khan, Kashif

    2014-01-01T23:59:59.000Z

    The scale of scientific High Performance Computing (HPC) and High Throughput Computing (HTC) has increased significantly in recent years, and is becoming sensitive to total energy use and cost. Energy-efficiency has thus become an important concern in scientific fields such as High Energy Physics (HEP). There has been a growing interest in utilizing alternate architectures, such as low power ARM processors, to replace traditional Intel x86 architectures. Nevertheless, even though such solutions have been successfully used in mobile applications with low I/O and memory demands, it is unclear if they are suitable and more energy-efficient in the scientific computing environment. Furthermore, there is a lack of tools and experience to derive and compare power consumption between the architectures for various workloads, and eventually to support software optimizations for energy efficiency. To that end, we have performed several physical and software-based measurements of workloads from HEP applications running o...

  17. Workflow Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    at NERSC go here. Galaxy - Galaxy is a web based workflow tool that is use by the genomics community. It allows you to define job dependencies via a web based workflow engine....

  18. Queer Tools

    E-Print Network [OSTI]

    Hacker, Randi; Tsutsui, William

    2007-11-19T23:59:59.000Z

    Broadcast Transcript: Chindogu. Did someone say "Bless you?" No need. This is a Japanese word that means "queer tools" and it was coined to describe the Japanese penchant for unusual inventions. From toilet paper rolls that attach to the head...

  19. How the HYPATIA analysis tool is used as a hands-on experience to introduce HEP to high schools

    E-Print Network [OSTI]

    The ATLAS collaboration

    2015-01-01T23:59:59.000Z

    HYPATIA'' is a tool for interactive analysis of data from the ATLAS experiment at the Large Hadron Collider of CERN. It has been created by the authors and has been evolving over a number of years. It is available in a dowloadable version, which is regularly used in the International Masterclasses, and an online version which now exists in the form of a webapp. Furthermore, the data from ATLAS, which are necessary for performing different educational analysis paths, are available online. Such examples of interactive analyses vary from the estimation of the magnetic field of the ATLAS solenoid magnet, to detecting \\textquotedblleft pseudo\\textquotedblright~ Higgs events. These applications have been used in recent years in a large number of schools in the form of a half-day mini local (or even remote) masterclass. These activities have been supported by various European Union outreach programs which give emphasis to promoting science education in schools through new methods based on the inquiry based technique...

  20. Development and application of management tools within a high-mix, low-volume lean aerospace manufacturing environment

    E-Print Network [OSTI]

    McKenney, Kevin (Kevin Bryan), 1977-

    2005-01-01T23:59:59.000Z

    The design and implementation of a lean production system is a complex task requiring an intimate understanding of the fundamental lean principles. Much of the published lean literature is written at a high level of ...

  1. Multiscale Toxicology- Building the Next Generation Tools for Toxicology

    SciTech Connect (OSTI)

    Retterer, S. T. [ORNL] [ORNL; Holsapple, M. P. [Battelle Memorial Institute] [Battelle Memorial Institute

    2013-10-31T23:59:59.000Z

    A Cooperative Research and Development Agreement (CRADA) was established between Battelle Memorial Institute (BMI), Pacific Northwest National Laboratory (PNNL), Oak Ridge National Laboratory (ORNL), Brookhaven National Laboratory (BNL), Lawrence Livermore National Laboratory (LLNL) with the goal of combining the analytical and synthetic strengths of the National Laboratories with BMI?s expertise in basic and translational medical research to develop a collaborative pipeline and suite of high throughput and imaging technologies that could be used to provide a more comprehensive understanding of material and drug toxicology in humans. The Multi-Scale Toxicity Initiative (MSTI), consisting of the team members above, was established to coordinate cellular scale, high-throughput in vitro testing, computational modeling and whole animal in vivo toxicology studies between MSTI team members. Development of a common, well-characterized set of materials for testing was identified as a crucial need for the initiative. Two research tracks were established by BMI during the course of the CRADA. The first research track focused on the development of tools and techniques for understanding the toxicity of nanomaterials, specifically inorganic nanoparticles (NPs). ORNL?s work focused primarily on the synthesis, functionalization and characterization of a common set of NPs for dissemination to the participating laboratories. These particles were synthesized to retain the same surface characteristics and size, but to allow visualization using the variety of imaging technologies present across the team. Characterization included the quantitative analysis of physical and chemical properties of the materials as well as the preliminary assessment of NP toxicity using commercially available toxicity screens and emerging optical imaging strategies. Additional efforts examined the development of high-throughput microfluidic and imaging assays for measuring NP uptake, localization, and toxicity in vitro. The second research track within the MSTI CRADA focused on the development of ex vivo animal models for examining druginduced cardiotoxicity. ORNL's role in the second track was limited initially, but was later expanded to include the development of microfluidic platforms that might facilitate the translation of Cardiac 'Microwire' technologies developed at the University of Toronto into a functional platform for drug screening and predictive assessment of cardiotoxicity via highthroughput measurements of contractility. This work was coordinated by BMI with the Centre for the Commercialization of Regenerative Medicine (CCRM) and the University of Toronto (U Toronto). This partnership was expanded and culminated in the submission of proposal to Work for Others (WFO) agencies to explore the development of a broader set of microphysiological systems, a so call human-on-a-chip, that could be used for toxicity screening and the evaluation of bio-threat countermeasures.

  2. New capability will help accelerate design improvements by providing a high-fidelity simulation tool to study power

    E-Print Network [OSTI]

    New capability will help accelerate design improvements by providing a high-fidelity simulation augmentation and use of the combined LES-hydroelastic code will help accelerate the development of effective, efficient, and reliable hydrokinetic energy conversion technologies, thus helping to lower the cost

  3. Throughput-cost analysis of optical flow switching

    E-Print Network [OSTI]

    Chan, Vincent W. S.

    In this paper, we employ a cost model embodying major sources of capital expenditure (CapEx) to compare the throughput-cost tradeoff offered by optical flow switching to that of more traditional optical network architectures.

  4. Maximizing the throughput of large ad hoc wireless networks

    E-Print Network [OSTI]

    Hua, Y; Huang, Y; Garcia-Luna-Aceves, J J

    2006-01-01T23:59:59.000Z

    multi-input, single-output (MISO) protocol. During eachthe maximum throughput of the MISO protocol, in bits-meters/s/ Hz/node, is C MISO = (n ? 1) A log 2 1 + 2n P T ? h

  5. A scalable tools communication infrastructure.

    SciTech Connect (OSTI)

    Buntinas, D.; Bosilca, G.; Graham, R. L.; Vallee, G.; Watson, G. R.; Mathematics and Computer Science; Univ. of Tennessee; ORNL; IBM

    2008-07-01T23:59:59.000Z

    The Scalable Tools Communication Infrastructure (STCI) is an open source collaborative effort intended to provide high-performance, scalable, resilient, and portable communications and process control services for a wide variety of user and system tools. STCI is aimed specifically at tools for ultrascale computing and uses a component architecture to simplify tailoring the infrastructure to a wide range of scenarios. This paper describes STCI's design philosophy, the various components that will be used to provide an STCI implementation for a range of ultrascale platforms, and a range of tool types. These include tools supporting parallel run-time environments, such as MPI, parallel application correctness tools and performance analysis tools, as well as system monitoring and management tools.

  6. A Scalable Tools Communication Infrastructure

    SciTech Connect (OSTI)

    Buntinas, Darius [Argonne National Laboratory (ANL); Bosilca, George [University of Tennessee, Knoxville (UTK); Graham, Richard L [ORNL; Vallee, Geoffroy R [ORNL; Watson, Gregory R. [IBM T. J. Watson Research Center

    2008-01-01T23:59:59.000Z

    The Scalable Tools Communication Infrastructure (STCI) is an open source collaborative effort intended to provide high-performance, scalable, resilient, and portable communications and process control services for a wide variety of user and system tools. STCI is aimed specifically at tools for ultrascale computing and uses a component architecture to simplify tailoring the infrastructure to a wide range of scenarios. This paper describes STCI's design philosophy, the various components that will be used to provide an STCI implementation for a range of ultrascale platforms, and a range of tool types. These include tools supporting parallel run-time environments, such as MPI, parallel application correctness tools and performance analysis tools, as well as system monitoring and management tools.

  7. Toward a Performance/Resilience Tool for Hardware/Software Co-Design of High-Performance Computing Systems

    SciTech Connect (OSTI)

    Engelmann, Christian [ORNL] [ORNL; Naughton, III, Thomas J [ORNL

    2013-01-01T23:59:59.000Z

    xSim is a simulation-based performance investigation toolkit that permits running high-performance computing (HPC) applications in a controlled environment with millions of concurrent execution threads, while observing application performance in a simulated extreme-scale system for hardware/software co-design. The presented work details newly developed features for xSim that permit the injection of MPI process failures, the propagation/detection/notification of such failures within the simulation, and their handling using application-level checkpoint/restart. These new capabilities enable the observation of application behavior and performance under failure within a simulated future-generation HPC system using the most common fault handling technique.

  8. Statistical Algorithms for High-throughput Biological Data /

    E-Print Network [OSTI]

    Jeong, Kyowon

    2013-01-01T23:59:59.000Z

    Nat Genet, Jun 2012. [LHW + 09] Heng Li, Bob Handsaker, Alec25(16):20782079, [Li11] Heng Li. Tabix: fast retrieval ofYang, Chun-Qing Song, Le-Heng Wang, Chao Liu, Yan Fu, Zuo-

  9. High-throughput liquid-absorption preconcentrator sampling methods

    DOE Patents [OSTI]

    Zaromb, S.

    1994-07-12T23:59:59.000Z

    A system for detecting trace concentrations of an analyte in air includes a preconcentrator for the analyte and an analyte detector. The preconcentrator includes an elongated tubular container comprising a wettable material. The wettable material is continuously wetted with an analyte-sorbing liquid which flows from one part of the container to a lower end. Sampled air flows through the container in contact with the wetted material with a swirling motion which results in efficient transfer of analyte vapors or aerosol particles to the sorbing liquid and preconcentration of traces of analyte in the liquid. The preconcentrated traces of analyte may be either detected within the container or removed therefrom for injection into a separate detection means or for subsequent analysis. 12 figs.

  10. High-Throughput Mode Liquid Microjunction Surface Sampling Probe

    SciTech Connect (OSTI)

    Van Berkel, Gary J [ORNL; Kertesz, Vilmos [ORNL; King, Richard C. [PharmaCadence

    2009-01-01T23:59:59.000Z

    A simple and automated spot sampling operation mode for a liquid microjunction surface sampling probe/electrospray ionization mass spectrometry (LMJ-SSP/ESI-MS) system is reported. Prior manual and automated spot sampling methods with this probe relied on a careful, relatively slow alignment of the probe and surface distance (<20 m spacing) to form the probe-to-surface liquid microjunction critical to successful surface sampling. Moreover, sampling multiple spots required retraction of the surface from the probe and a repeat of this careful probe-to-surface distance alignment at the next sampling position. With the method described here, the probe was not positioned as close to the surface, the exact probeto-surface positioning was found to be less critical (spanning distances from about 100-300 m), and this distance was not altered during the sampling of an entire array of sample spots. With the probe positioned within the appropriate distance from the surface, the liquid microjunction was formed by letting the liquid from the sampling end of the probe extend out from the probe to the surface. This was accomplished by reducing the selfaspiration liquid flow rate of the probe to a value less than the volume flow rate pumped into the probe. When the self-aspiration rate of the probe was subsequently increased, analytes on the surface that dissolved at the liquid microjunction were aspirated back into the probe with the liquid that created the liquid microjunction and electrosprayed. Presented here are the basics of this new sampling mode, as well as data that illustrate the potential analytical capabilities of the device to conduct highthroughput quantitative analysis.

  11. Operational streamlining in a high-throughput genome sequencing center

    E-Print Network [OSTI]

    Person, Kerry P. (Kerry Patrick)

    2006-01-01T23:59:59.000Z

    Advances in medicine rely on accurate data that is rapidly provided. It is therefore critical for the Genome Sequencing platform of the Broad Institute of MIT and Harvard to continually strive to reduce cost, improve ...

  12. Methods and devices for high-throughput dielectrophoretic concentration

    DOE Patents [OSTI]

    Simmons, Blake A. (San Francisco, CA); Cummings, Eric B. (Livermore, CA); Fiechtner, Gregory J. (Germantown, MD); Fintschenko, Yolanda (Livermore, CA); McGraw, Gregory J. (Ann Arbor, MI); Salmi, Allen (Escalon, CA)

    2010-02-23T23:59:59.000Z

    Disclosed herein are methods and devices for assaying and concentrating analytes in a fluid sample using dielectrophoresis. As disclosed, the methods and devices utilize substrates having a plurality of pores through which analytes can be selectively prevented from passing, or inhibited, on application of an appropriate electric field waveform. The pores of the substrate produce nonuniform electric field having local extrema located near the pores. These nonuniform fields drive dielectrophoresis, which produces the inhibition. Arrangements of electrodes and porous substrates support continuous, bulk, multi-dimensional, and staged selective concentration.

  13. Integrated microbioreactor arrays for high-throughput experimentation

    E-Print Network [OSTI]

    Lee, Harry, 1976-

    2006-01-01T23:59:59.000Z

    Bioprocesses with microbial cells play an important role in producing biopharmaceuticals such as human insulin and human growth hormone, and other products such as amino acids and biopolymers. Because bioprocesses involve ...

  14. High Throughput Combinatorial Screening of Biometic Metal-Organic...

    Broader source: Energy.gov (indexed) [DOE]

    - 50 cm -1 ) red-shifts upon adsorption *Can be complex, depending on exact adsorption environment *Partial charge transfer weakens H-H bond, red-shift *Are such strong...

  15. An apparatus for high throughput muscle cell experimentation

    E-Print Network [OSTI]

    Garcia-Webb, Michael G. (Michael Gregory)

    2006-01-01T23:59:59.000Z

    The cardiac ventricular muscle cell (myocyte) is a key experimental system for exploring the mechanical properties of the diseased and healthy heart. The myocyte experimental model provides a higher level of physiological ...

  16. High-Throughput and Combinatorial Screening of Hydrogen Storage...

    Broader source: Energy.gov (indexed) [DOE]

    method The sintering technique is used by groups at: U. Geneva (Switzerland), MPI (Germany), Stockholm University (Sweden), IFE (Norway), SRNL (USA), U. Tohoku, AIST (Japan)...

  17. Constant pressure high throughput membrane permeation testing system

    DOE Patents [OSTI]

    Albenze, Erik J.; Hopkinson, David P.; Luebke, David R.

    2014-09-02T23:59:59.000Z

    The disclosure relates to a membrane testing system for individual evaluation of a plurality of planar membranes subjected to a feed gas on one side and a sweep gas on a second side. The membrane testing system provides a pressurized flow of a feed and sweep gas to each membrane testing cell in a plurality of membrane testing cells while a stream of retentate gas from each membrane testing cell is ported by a retentate multiport valve for sampling or venting, and a stream of permeate gas from each membrane testing cell is ported by a permeate multiport valve for sampling or venting. Back pressure regulators and mass flow controllers act to maintain substantially equivalent gas pressures and flow rates on each side of the planar membrane throughout a sampling cycle. A digital controller may be utilized to position the retentate and permeate multiport valves cyclically, allowing for gas sampling of different membrane cells over an extended period of time.

  18. High-Throughput Transfer Imprinting for Organic Semiconductors

    E-Print Network [OSTI]

    Choo, Gihoon

    2013-08-06T23:59:59.000Z

    focused infrared laser heats stamping layer(PMMA) up to glass transition temperature within very short time. And the pressure applied through the roller presses the flat mold and the pattern is imprinted on the PMMA layer. This method can imprint... with higher speed and achieved wider area of imprinting than conventional imprint method. [17] MOLD Substrate PMMA IR Roller Figure 8 Concept of roller imprinting based on focus infrared heating. 17 CHAPTER II PROBLEM STATEMENT...

  19. Technology Offer High-throughput Algorithm for Automated

    E-Print Network [OSTI]

    reliability enables the same LC-MS analyses with less human resources as manual correction is not necessary Chemical industry: identification and quantitation of chemical composition of various analytes, e.g. oils

  20. High throughput analysis of samples in flowing liquid

    DOE Patents [OSTI]

    Ambrose, W. Patrick (Los Alamos, NM); Grace, W. Kevin (Los Alamos, NM); Goodwin, Peter M. (Los Alamos, NM); Jett, James H. (Los Alamos, NM); Orden, Alan Van (Fort Collins, CO); Keller, Richard A. (White Rock, NM)

    2001-01-01T23:59:59.000Z

    Apparatus and method enable imaging multiple fluorescent sample particles in a single flow channel. A flow channel defines a flow direction for samples in a flow stream and has a viewing plane perpendicular to the flow direction. A laser beam is formed as a ribbon having a width effective to cover the viewing plane. Imaging optics are arranged to view the viewing plane to form an image of the fluorescent sample particles in the flow stream, and a camera records the image formed by the imaging optics.

  1. High-throughput comparison of gene fitness among related bacteria

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    licenses/by/2.0), which permits unrestricted use,Mutations in this gene permit second site mutations in hnsIt is known that rpoS mutants permit mutations in hns in

  2. Vectorized AES core for high-throughput secure environments

    E-Print Network [OSTI]

    Kuzmanov, Georgi

    `odul D6 Campus Nord, 08034 Barcelona, Spain Phone: +34 934 017 001, Fax: +34 934 017 055 mpericas the evaluation of an encryption core capable of handling multiple data streams. The de- sign is oriented towards cryptographic engines with multiple streams to better exploit the available bandwidth. Several specific cases

  3. High-throughput Synthesis and Metrology of Graphene Materials

    E-Print Network [OSTI]

    Ghazinejad, Maziar Ghazinejad

    2012-01-01T23:59:59.000Z

    24 2.5 Demonstration of PGN based Supercapacitor2-11 (a) CV curves of supercapacitor based on as-grown PGNFigure 2-12 CV curves of supercapacitor based on HNO3 acid

  4. Potential of High-Throughput Experimentation with Ammonia Borane...

    Broader source: Energy.gov (indexed) [DOE]

    and theory - Materials Discovery DOE BES Hydrogen Fuel Initiative * Structure and dynamics (Neutron and NMR) - Experimental and computational studies of di- hydrogen bonding...

  5. Targeted Tandem Mass Spectrometry for High-Throughput Comparative

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security AdministrationcontrollerNanocrystallineForeign ObjectOUR8, 2013 FINAL MEETINGEnergy

  6. Catalyst Structure-Performance Relationship Identified by High-Throughput

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation Proposed New Substation Sites ProposedOccupational Health Services >CatalysisOperando

  7. High mass throughput particle generation using multiple nozzle spraying

    DOE Patents [OSTI]

    Pui, David Y. H. (Plymouth, MN); Chen, Da-Ren (Creve Coeur, MO)

    2009-03-03T23:59:59.000Z

    Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.

  8. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassive Solar HomePromisingStories »SubmitterJ. NorbyN. ComptonRobotRobust,

  9. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas ConchasPassive Solar HomePromisingStories »SubmitterJ. NorbyN. ComptonRobotRobust,Robust,

  10. High Throughput Operando Studies using Fourier Transform Infrared Imaging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinement plasmas in thein the Assembly of PhotosystemVehicles andand

  11. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared0 Resource Program SeptemberRobertIntelligentRobust,

  12. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared0 Resource Program SeptemberRobertIntelligentRobust,Robust,

  13. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared0 Resource Program SeptemberRobertIntelligentRobust,Robust,Robust,

  14. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared0 Resource Program

  15. Potential of High-Throughput Experimentation with Ammonia Borane Solid

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankCombustion | Department ofT ib l L d FNEPA/309 Reviewers | DepartmentSiteMaryland | YieldHydrogen Storage

  16. High-Throughput Analytical Model to Evaluate Materials for Temperature

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest Region service area.Portal Solar Photovoltaic SolarSwing Adsorption

  17. High-Throughput Characterization of Porous Materials Using Graphics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest Region service area.Portal Solar Photovoltaic SolarSwing

  18. High-Throughput and Combinatorial Screening of Hydrogen Storage Materials

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeatMulti-Dimensional Subject:Ground HawaiiWaste Heat Recovery: Successa

  19. NETL Studies High Throughput Membrane Screening | netl.doe.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Opticalhttp://www.fnal.gov/directorate/nalcal/nalcal02_07_05_files/nalcal.gifAEnergy Scientist Named FinalistNETLNETL

  20. Advancing the High Throughput Identification of Liver Fibrosis Protein

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc Documentation RUCProductstwrmrAre theAdministratorCFM LEAP Aircraft

  1. Antibody Microarrays for High-Throughput, Multianalyte Analysis. | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone by E-mail ShareRedAndreasAnodedemonstrates that

  2. Techniques and tools for measuring energy efficiency of scientific software applications

    E-Print Network [OSTI]

    David Abdurachmanov; Peter Elmer; Giulio Eulisse; Robert Knight; Tapio Niemi; Jukka K. Nurminen; Filip Nyback; Goncalo Pestana; Zhonghong Ou; Kashif Khan

    2014-10-10T23:59:59.000Z

    The scale of scientific High Performance Computing (HPC) and High Throughput Computing (HTC) has increased significantly in recent years, and is becoming sensitive to total energy use and cost. Energy-efficiency has thus become an important concern in scientific fields such as High Energy Physics (HEP). There has been a growing interest in utilizing alternate architectures, such as low power ARM processors, to replace traditional Intel x86 architectures. Nevertheless, even though such solutions have been successfully used in mobile applications with low I/O and memory demands, it is unclear if they are suitable and more energy-efficient in the scientific computing environment. Furthermore, there is a lack of tools and experience to derive and compare power consumption between the architectures for various workloads, and eventually to support software optimizations for energy efficiency. To that end, we have performed several physical and software-based measurements of workloads from HEP applications running on ARM and Intel architectures, and compare their power consumption and performance. We leverage several profiling tools (both in hardware and software) to extract different characteristics of the power use. We report the results of these measurements and the experience gained in developing a set of measurement techniques and profiling tools to accurately assess the power consumption for scientific workloads.

  3. Development of a HT Seismic Tool

    Broader source: Energy.gov [DOE]

    The program objective is to design; fabricate and field test two high temperature (HT) seismic tools in an EGS application.

  4. Slide system for machine tools

    DOE Patents [OSTI]

    Douglass, Spivey S. (Oak Ridge, TN); Green, Walter L. (Knoxville, TN)

    1982-01-01T23:59:59.000Z

    The present invention relates to a machine tool which permits the machining of nonaxisymmetric surfaces on a workpiece while rotating the workpiece about a central axis of rotation. The machine tool comprises a conventional two-slide system (X-Y) with one of these slides being provided with a relatively short travel high-speed auxiliary slide which carries the material-removing tool. The auxiliary slide is synchronized with the spindle speed and the position of the other two slides and provides a high-speed reciprocating motion required for the displacement of the cutting tool for generating a nonaxisymmetric surface at a selected location on the workpiece.

  5. Slide system for machine tools

    DOE Patents [OSTI]

    Douglass, S.S.; Green, W.L.

    1980-06-12T23:59:59.000Z

    The present invention relates to a machine tool which permits the machining of nonaxisymmetric surfaces on a workpiece while rotating the workpiece about a central axis of rotation. The machine tool comprises a conventional two-slide system (X-Y) with one of these slides being provided with a relatively short travel high-speed auxiliary slide which carries the material-removing tool. The auxiliary slide is synchronized with the spindle speed and the position of the other two slides and provides a high-speed reciprocating motion required for the displacement of the cutting tool for generating a nonaxisymmetric surface at a selected location on the workpiece.

  6. System Software and Tools for High Performance Computing Environments: A report on the findings of the Pasadena Workshop, April 14--16, 1992

    SciTech Connect (OSTI)

    Sterling, T. [Universities Space Research Association, Washington, DC (United States); Messina, P. [Jet Propulsion Lab., Pasadena, CA (United States); Chen, M. [Yale Univ., New Haven, CT (United States)] [and others

    1993-04-01T23:59:59.000Z

    The Pasadena Workshop on System Software and Tools for High Performance Computing Environments was held at the Jet Propulsion Laboratory from April 14 through April 16, 1992. The workshop was sponsored by a number of Federal agencies committed to the advancement of high performance computing (HPC) both as a means to advance their respective missions and as a national resource to enhance American productivity and competitiveness. Over a hundred experts in related fields from industry, academia, and government were invited to participate in this effort to assess the current status of software technology in support of HPC systems. The overall objectives of the workshop were to understand the requirements and current limitations of HPC software technology and to contribute to a basis for establishing new directions in research and development for software technology in HPC environments. This report includes reports written by the participants of the workshop`s seven working groups. Materials presented at the workshop are reproduced in appendices. Additional chapters summarize the findings and analyze their implications for future directions in HPC software technology development.

  7. Research Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest RegionatSearch Welcome toResearch Areas OurLANLSoftware & Tools

  8. Tools | JCESR

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation Desert Southwest RegionatSearchScheduled System BurstLongTitan Titan is a two-beamTools JCESR

  9. Enrollment Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series toESnet4: Networking for37EnergyNuclear SecurityEnolEnrollment Tools

  10. Customization for tool design

    SciTech Connect (OSTI)

    Michaelson, B.

    1985-10-01T23:59:59.000Z

    ICEMDDN capabilities have been adapted to the specific needs of the tool designer for creation of tool and gage designs. A customized graphic system allows the designer to concentrate on the design task, not on the mechanics of the graphs system. Prerequisites of customization include management support, user acceptance, user contributions, CAD/CAM operations support and cooperation from Control Data Corporation. Benefits from customization included a measurable increase in design production, better completion schedules, high quality drawings with better accuracy, and job satisfaction from participation in system development and improvement.

  11. A TRANSPORTATION RISK ASSESSMENT TOOL FOR ANALYZING THE TRANSPORT OF SPENT NUCLEAR FUEL AND HIGH-LEVEL RADIOACTIVE WASTE TO THE PROPOSED YUCCA MOUNTAIN REPOSITORY

    SciTech Connect (OSTI)

    NA

    2001-02-15T23:59:59.000Z

    The Yucca Mountain Draft Environmental Impact Statement (DEIS) analysis addressed the potential for transporting spent nuclear fuel and high-level radioactive waste from 77 origins for 34 types of spent fuel and high-level radioactive waste, 49,914 legal weight truck shipments, and 10,911 rail shipments. The analysis evaluated transportation over 59,250 unique shipment links for travel outside Nevada (shipment segments in urban, suburban or rural zones by state), and 22,611 links in Nevada. In addition, the analysis modeled the behavior of 41 isotopes, 1091 source terms, and used 8850 food transfer factors (distinct factors by isotope for each state). The analysis also used mode-specific accident rates for legal weight truck, rail, and heavy haul truck by state, and barge by waterway. This complex mix of data and information required an innovative approach to assess the transportation impacts. The approach employed a Microsoft{reg_sign} Access database tool that incorporated data from many sources, including unit risk factors calculated using the RADTRAN IV transportation risk assessment computer program. Using Microsoft{reg_sign} Access, the analysts organized data (such as state-specific accident and fatality rates) into tables and developed queries to obtain the overall transportation impacts. Queries are instructions to the database describing how to use data contained in the database tables. While a query might be applied to thousands of table entries, there is only one sequence of queries that is used to calculate a particular transportation impact. For example, the incident-free dose to off-link populations in a state is calculated by a query that uses route segment lengths for each route in a state that could be used by shipments, populations for each segment, number of shipments on each segment, and an incident-free unit risk factor calculated using RADTRAN IV. In addition to providing a method for using large volumes of data in the calculations, the queries provide a straight-forward means used to verify results. Another advantage of using the MS Access database was the ability to develop query hierarchies using nested queries. Calculations were broken into a series of steps, each step represented by a query. For example, the first query might calculate the number of shipment kilometers traveled through urban, rural and suburban zones for all states. Subsequent queries could join the shipment kilometers query results with another table containing unit risk factors calculated using RADTRAN IV to produce radiological impacts. Through the use of queries, impacts by origin, mode, fuel type or many other parameters can be obtained. The paper will show both the flexibility of the assessment tool and the ease it provides for verifying results.

  12. Modeling of Tool Wear and Tool Fracture in Micromilling

    E-Print Network [OSTI]

    Shiosaki, Dominic

    2012-02-14T23:59:59.000Z

    implants. Micromilling has the potential to be the most cost effective and efficient material removal process due to ease of use and accessibility of the tools. This research analyzes vibration of a high speed spindle and then studies micromilling...

  13. Applying Speculative Technique to Improve TCP Throughput over Lossy Links

    E-Print Network [OSTI]

    Atiquzzaman, Mohammed

    @ou.edu Abstract-- The throughput degradation of Transport Control Protocol (TCP) over lossy links due performance due to control hazards in CPU design. First, two types of loss events in networks with lossy links links are involved in TCP connections. The objective of this paper is to propose a protocol

  14. Reliability and Throughput in Future Automotive Communication Networks

    E-Print Network [OSTI]

    Rajkumar, Ragunathan "Raj"

    Reliability and Throughput in Future Automotive Communication Networks John Liu, Timothy TaltyStar. This action created a new industry called automotive telematics, helping to save lives and providing, the automotive telematics industry has experienced a healthy growth in North America. During the current economic

  15. Dynamic Power Allocation For Maximizing Throughput in Energy Harvesting

    E-Print Network [OSTI]

    Vaze, Rahul

    1 Dynamic Power Allocation For Maximizing Throughput in Energy Harvesting Communication System general case of arbitrarily varying energy arrivals is considered, where neither the future energy arrival strategy that invests available energy uniformly over all remaining slots until the next energy arrival

  16. Automatic Memory Partitioning and Scheduling for Throughput and Power Optimization

    E-Print Network [OSTI]

    Cong, Jason "Jingsheng"

    - matic memory partitioning technique which can efficiently improve throughput and reduce energy to tackle this problem is to increase memory ports in the final memory imple- mentations. However, recent research in [16] shows that the size of memory cells increases almost quadratically with port number N

  17. Throughput Enhancing Cooperative Spectrum Sensing Strategies for Cognitive Radios

    E-Print Network [OSTI]

    Yener, Aylin

    Throughput Enhancing Cooperative Spectrum Sensing Strategies for Cognitive Radios Kyounghwan Lee growth of wireless services continues to accelerate the exhaustion of usable radio spectrum. The radio channels licensed to the primary users. A main chal- lenge in this case is to design a spectrum sensing

  18. Optimizing Throughput and Energy in Online Deadline Scheduling

    E-Print Network [OSTI]

    Wong, Prudence W.H.

    of all jobs. An optimal schedule is expected to maximize the throughput, and furthermore, its energy a scheduling algorithm, one has to face the dilemma of selecting more jobs and being conservative in energy jobs; O(1)-competitive online algorithms with respect to energy usage have been known [Yao et al. 1995

  19. Results of the WFPC2 SM3a Lyman-Throughput Check (proposals 8492, 8494,

    E-Print Network [OSTI]

    Sirianni, Marco

    and F122M filters, are designed to monitor the far-UV throughput for any signs of degradation which may and I. Heyer March 16, 2000 ABSTRACT The far-UV throughput of WFPC2 was monitored during December 1999 and January 2000 for any signs of unexpected throughput degradation following Servicing Mission 3a

  20. High Sensitivity Proteomics Assisted Discovery of a Novel Operon...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the water oxidation reactions of the photosynthetic electron transport chain in plants, algae, and cyanobacteria. Utilizing a high-throughput proteomic analysis of isolated PSII...

  1. ascidiacea high genome: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Daniel S. (Daniel Southwick), 1977- 2004-01-01 3 Data Management for High-Throughput Genomics CERN Preprints Summary: Today's sequencing technology allows sequencing an individual...

  2. A Transportation Risk Assessment Tool for Analyzing the Transport of Spent Nuclear Fuel and High-Level Radioactive Waste to the Proposed Yucca Mountain Repository

    SciTech Connect (OSTI)

    Ralph Best; T. Winnard; S. Ross; R. Best

    2001-08-17T23:59:59.000Z

    The Yucca Mountain Transportation Database was developed as a data management tool for assembling and integrating data from multiple sources to compile the potential transportation impacts presented in the Draft Environmental Impact Statement for a Geologic Repository for the Disposal of Spent Nuclear Fuel and High-Level Radioactive Waste at Yucca Mountain, Nye County, Nevada (DEIS). The database uses the results from existing models and codes such as RADTRAN, RISKIND, INTERLINE, and HIGHWAY to estimate transportation-related impacts of transporting spent nuclear fuel and high-level radioactive waste from commercial reactors and U. S. Department of Energy (DOE) facilities to Yucca Mountain. The source tables in the database are compendiums of information from many diverse sources including: radionuclide quantities for each waste type; route and route characteristics for rail, legal-weight truck, heavy haul. truck, and barge transport options; state-specific accident and fatality rates for routes selected for analysis; packaging and shipment data by waste type; unit risk factors; the complex behavior of the packaged waste forms in severe transport accidents; and the effects of exposure to radiation or the isotopic specific effects of radionclides should they be released in severe transportation accidents. The database works together with the codes RADTRAN (Neuhauser, et al, 1994) and RISKlND (Yuan, et al, 1995) to calculate incident-free dose and accident risk. For the incident-free transportation scenario, the database uses RADTRAN and RISKIND-generated data to calculate doses to offlink populations, onlink populations, people at stops, crews, inspectors, workers at intermodal transfer stations, guards at overnight stops, and escorts, as well as non-radioactive pollution health effects. For accident scenarios, the database uses RADTRAN-generated data to calculate dose risks based on ingestion, inhalation, resuspension, immersion (cloudshine), and groundshine as well as non-radioactive traffic fatalities. The Yucca Mountain EIS Transportation Database was developed using Microsoft Access 97{trademark} software and the Microsoft Windows NT{trademark} operating system. The database consists of tables for storing data, forms for selecting data for querying, and queries for retrieving the data in a predefined format. Database queries retrieve records based on input parameters and are used to calculate incident-free and accident doses using unit risk factors obtained from RADTRAN results. The next section briefly provides some background that led to the development of the database approach used in preparing the Yucca Mountain DEIS. Subsequent sections provide additional details on the database structure and types of impacts calculated using the database.

  3. A Mission-Centric Visualization Tool for Cybersecurity Situation Awareness

    E-Print Network [OSTI]

    California at Santa Barbara, University of

    A Mission-Centric Visualization Tool for Cybersecurity Situation Awareness Nichole Stockman Four tool that provides high- level situation awareness for cybersecurity scenarios. Our visualization tool competition, which was designed to mirror general cybersecurity scenar- ios that would be encountered

  4. Automated Steel Cleanliness Analysis Tool (ASCAT)

    SciTech Connect (OSTI)

    Gary Casuccio (RJ Lee Group); Michael Potter (RJ Lee Group); Fred Schwerer (RJ Lee Group); Dr. Richard J. Fruehan (Carnegie Mellon University); Dr. Scott Story (US Steel)

    2005-12-30T23:59:59.000Z

    The objective of this study was to develop the Automated Steel Cleanliness Analysis Tool (ASCATTM) to permit steelmakers to evaluate the quality of the steel through the analysis of individual inclusions. By characterizing individual inclusions, determinations can be made as to the cleanliness of the steel. Understanding the complicating effects of inclusions in the steelmaking process and on the resulting properties of steel allows the steel producer to increase throughput, better control the process, reduce remelts, and improve the quality of the product. The ASCAT (Figure 1) is a steel-smart inclusion analysis tool developed around a customized next-generation computer controlled scanning electron microscopy (NG-CCSEM) hardware platform that permits acquisition of inclusion size and composition data at a rate never before possible in SEM-based instruments. With built-in customized ''intelligent'' software, the inclusion data is automatically sorted into clusters representing different inclusion types to define the characteristics of a particular heat (Figure 2). The ASCAT represents an innovative new tool for the collection of statistically meaningful data on inclusions, and provides a means of understanding the complicated effects of inclusions in the steel making process and on the resulting properties of steel. Research conducted by RJLG with AISI (American Iron and Steel Institute) and SMA (Steel Manufactures of America) members indicates that the ASCAT has application in high-grade bar, sheet, plate, tin products, pipes, SBQ, tire cord, welding rod, and specialty steels and alloys where control of inclusions, whether natural or engineered, are crucial to their specification for a given end-use. Example applications include castability of calcium treated steel; interstitial free (IF) degasser grade slag conditioning practice; tundish clogging and erosion minimization; degasser circulation and optimization; quality assessment/steel cleanliness; slab, billet or bloom disposition; and alloy development. Additional benefits of ASCAT include the identification of inclusions that tend to clog nozzles or interact with refractory materials. Several papers outlining the benefits of the ASCAT have been presented and published in the literature. The paper entitled ''Inclusion Analysis to Predict Casting Behavior'' was awarded the American Iron and Steel Institute (AISI) Medal in 2004 for special merit and importance to the steel industry. The ASCAT represents a quantum leap in inclusion analysis and will allow steel producers to evaluate the quality of steel and implement appropriate process improvements. In terms of performance, the ASCAT (1) allows for accurate classification of inclusions by chemistry and morphological parameters, (2) can characterize hundreds of inclusions within minutes, (3) is easy to use (does not require experts), (4) is robust, and (5) has excellent image quality for conventional SEM investigations (e.g., the ASCAT can be utilized as a dual use instrument). In summary, the ASCAT will significantly advance the tools of the industry and addresses an urgent and broadly recognized need of the steel industry. Commercialization of the ASCAT will focus on (1) a sales strategy that leverages our Industry Partners; (2) use of ''technical selling'' through papers and seminars; (3) leveraging RJ Lee Group's consulting services, and packaging of the product with a extensive consulting and training program; (4) partnering with established SEM distributors; (5) establishing relationships with professional organizations associated with the steel industry; and (6) an individualized plant by plant direct sales program.

  5. Development and implementation of a remote audit tool for high dose rate (HDR) Ir-192 brachytherapy using optically stimulated luminescence dosimetry

    SciTech Connect (OSTI)

    Casey, Kevin E.; Kry, Stephen F.; Howell, Rebecca M.; Followill, David [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030 (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 and The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, Texas 77030 (United States); Alvarez, Paola; Lawyer, Ann [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)] [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 (United States)

    2013-11-15T23:59:59.000Z

    Purpose: The aim of this work was to create a mailable phantom with measurement accuracy suitable for Radiological Physics Center (RPC) audits of high dose-rate (HDR) brachytherapy sources at institutions participating in National Cancer Institute-funded cooperative clinical trials. Optically stimulated luminescence dosimeters (OSLDs) were chosen as the dosimeter to be used with the phantom.Methods: The authors designed and built an 8 8 10 cm{sup 3} prototype phantom that had two slots capable of holding Al{sub 2}O{sub 3}:C OSLDs (nanoDots; Landauer, Glenwood, IL) and a single channel capable of accepting all {sup 192}Ir HDR brachytherapy sources in current clinical use in the United States. The authors irradiated the phantom with Nucletron and Varian {sup 192}Ir HDR sources in order to determine correction factors for linearity with dose and the combined effects of irradiation energy and phantom characteristics. The phantom was then sent to eight institutions which volunteered to perform trial remote audits.Results: The linearity correction factor was k{sub L}= (?9.43 10{sup ?5} dose) + 1.009, where dose is in cGy, which differed from that determined by the RPC for the same batch of dosimeters using {sup 60}Co irradiation. Separate block correction factors were determined for current versions of both Nucletron and Varian {sup 192}Ir HDR sources and these vendor-specific correction factors differed by almost 2.6%. For the Nucletron source, the correction factor was 1.026 [95% confidence interval (CI) = 1.0231.028], and for the Varian source, it was 1.000 (95% CI = 0.9951.005). Variations in lateral source positioning up to 0.8 mm and distal/proximal source positioning up to 10 mm had minimal effect on dose measurement accuracy. The overall dose measurement uncertainty of the system was estimated to be 2.4% and 2.5% for the Nucletron and Varian sources, respectively (95% CI). This uncertainty was sufficient to establish a 5% acceptance criterion for source strength audits under a formal RPC audit program. Trial audits of four Nucletron sources and four Varian sources revealed an average RPC-to-institution dose ratio of 1.000 (standard deviation = 0.011).Conclusions: The authors have created an OSLD-based {sup 192}Ir HDR brachytherapy source remote audit tool which offers sufficient dose measurement accuracy to allow the RPC to establish a remote audit program with a 5% acceptance criterion. The feasibility of the system has been demonstrated with eight trial audits to date.

  6. The power tool

    SciTech Connect (OSTI)

    HAYFIELD, J.P.

    1999-02-01T23:59:59.000Z

    POWER Tool--Planning, Optimization, Waste Estimating and Resourcing tool, a hand-held field estimating unit and relational database software tool for optimizing disassembly and final waste form of contaminated systems and equipment.

  7. TNA Data Collection Tool

    Broader source: Energy.gov [DOE]

    The TNA Data Collection Tool Instructions provides guidance on how to complete the TNA Data Collection Tool. The TNA Data Collection Tool is an Excel spreadsheet that the organization's designating training POC will use to populate their organizations training needs.

  8. FASTBUS simulation tools

    SciTech Connect (OSTI)

    Dean, T.D. (Stanford Linear Accelerator Center, Menlo Park, CA (United States)); Haney, M.J. (Illinois Univ., Urbana, IL (United States))

    1991-10-01T23:59:59.000Z

    A generalized model of a FASTBUS master is presented. The model is used with simulation tools to aid in the specification, design, and production of FASTBUS slave modules. The model provides a mechanism to interact with the electrical schematics and software models to predict performance. The model is written in the IEEE std 1076-1987 hardware description language VHDL. A model of the ATC logic is also presented. VHDL was chosen to provide portability to various platforms and simulation tools. The models, in conjunction with most commercially available simulators, will perform all of the transactions specified in IEEE std 960-1989. The models may be used to study the behavior of electrical schematics and other software models and detect violations of the FASTBUS protocol. For example, a hardware design of a slave module could be studied, protocol violations detected and corrected before committing money to prototype development. The master model accepts a stream of high level commands from an ASCII file to initiate FASTBUS transactions. The high level command language is based on the FASTBUS standard routines listed in IEEE std 1177-1989. Using this standard-based command language to direct the model of the master, hardware engineers can simulate FASTBUS transactions in the language used by physicists and programmers to operate FASTBUS systems. 15 refs., 6 figs.

  9. Hazardous Waste/Mixed Waste Treatment Building throughput study

    SciTech Connect (OSTI)

    England, J.L.; Kanzleiter, J.P.

    1991-12-18T23:59:59.000Z

    The hazardous waste/mixed waste HW/MW Treatment Building (TB) is the specified treatment location for solid hazardous waste/mixed waste at SRS. This report provides throughput information on the facility based on known and projected waste generation rates. The HW/MW TB will have an annual waste input for the first four years of approximately 38,000 ft{sup 3} and have an annual treated waste output of approximately 50,000 ft{sup 3}. After the first four years of operation it will have an annual waste input of approximately 16,000 ft{sup 3} and an annual waste output of approximately 18,000 ft. There are several waste streams that cannot be accurately predicted (e.g. environmental restoration, decommissioning, and decontamination). The equipment and process area sizing for the initial four years should allow excess processing capability for these poorly defined waste streams. A treatment process description and process flow of the waste is included to aid in understanding the computations of the throughput. A description of the treated wastes is also included.

  10. Foundational Tools for Petascale Computing

    SciTech Connect (OSTI)

    Miller, Barton

    2014-05-19T23:59:59.000Z

    The Paradyn project has a history of developing algorithms, techniques, and software that push the cutting edge of tool technology for high-end computing systems. Under this funding, we are working on a three-year agenda to make substantial new advances in support of new and emerging Petascale systems. The overall goal for this work is to address the steady increase in complexity of these petascale systems. Our work covers two key areas: (1) The analysis, instrumentation and control of binary programs. Work in this area falls under the general framework of the Dyninst API tool kits. (2) Infrastructure for building tools and applications at extreme scale. Work in this area falls under the general framework of the MRNet scalability framework. Note that work done under this funding is closely related to work done under a contemporaneous grant, High-Performance Energy Applications and Systems, SC0004061/FG02-10ER25972, UW PRJ36WV.

  11. Planning Tool for Strategic Evaluation of Facility Plans - 13570

    SciTech Connect (OSTI)

    Magoulas, Virginia; Cercy, Michael [Savannah River National Laboratory, Savannah River Site, Aiken, SC 29808 (United States)] [Savannah River National Laboratory, Savannah River Site, Aiken, SC 29808 (United States); Hall, Irin [Newport News Shipbuilding, 4101 Washington Ave., Newport News, VA 23607 (United States)] [Newport News Shipbuilding, 4101 Washington Ave., Newport News, VA 23607 (United States)

    2013-07-01T23:59:59.000Z

    Savannah River National Laboratory (SRNL) has developed a strategic planning tool for the evaluation of the utilization of its unique resources for processing and research and development of nuclear materials. The Planning Tool is a strategic level tool for assessing multiple missions that could be conducted utilizing the SRNL facilities and showcasing the plan. Traditional approaches using standard scheduling tools and laying out a strategy on paper tended to be labor intensive and offered either a limited or cluttered view for visualizing and communicating results. A tool that can assess the process throughput, duration, and utilization of the facility was needed. SRNL teamed with Newport News Shipbuilding (NNS), a division of Huntington Ingalls Industries, to create the next generation Planning Tool. The goal of this collaboration was to create a simulation based tool that allows for quick evaluation of strategies with respect to new or changing missions, and clearly communicates results to the decision makers. This tool has been built upon a mature modeling and simulation software previously developed by NNS. The Planning Tool provides a forum for capturing dependencies, constraints, activity flows, and variable factors. It is also a platform for quickly evaluating multiple mission scenarios, dynamically adding/updating scenarios, generating multiple views for evaluating/communicating results, and understanding where there are areas of risks and opportunities with respect to capacity. The Planning Tool that has been developed is useful in that it presents a clear visual plan for the missions at the Savannah River Site (SRS). It not only assists in communicating the plans to SRS corporate management, but also allows the area stakeholders a visual look at the future plans for SRS. The design of this tool makes it easily deployable to other facility and mission planning endeavors. (authors)

  12. Applications (Grid Tools)

    E-Print Network [OSTI]

    Buyya, Rajkumar

    Grid Fabric Software Grid Applications Core Grid Middleware User-Level Middleware (Grid Tools) !"# $ %& ' ( ) * #& + '& ' , - . / # ) ) 0 # * 1 PDB CDB Grid Fabric Hardware &+ '' + ) , '1 '1 ' % - * # ( Grid Fabric Software Grid Applications Core Grid Middleware User-Level Middleware (Grid Tools) !"# $ %& ' ( ) * #& + '& ' , - . / # ) ) 0

  13. Maximizing Throughput of UAV-Relaying Networks with the Load-Carry-and-Deliver Paradigm

    E-Print Network [OSTI]

    Kung, H. T.

    Maximizing Throughput of UAV-Relaying Networks with the Load-Carry-and-Deliver Paradigm Chen Unmanned Aerial Vehicles (UAVs) to relay messages between two distant ground nodes. For delay-tolerant applications like latency-insensitive bulk data transfer, we seek to maximize throughput by having a UAV load

  14. Improving TCP Throughput over Lossy Links Using Protocol-Level Speculations

    E-Print Network [OSTI]

    Minnesota, University of

    Improving TCP Throughput over Lossy Links Using Protocol-Level Speculations Haowei Bai Honeywell@ou.edu Abstract-- The degradation of Transport Control Protocol (TCP) throughput in networks with lossy links. This is very similar to processor performance degradation due to control hazards in CPU design. First, two

  15. OOTW COST TOOLS

    SciTech Connect (OSTI)

    HARTLEY, D.S.III; PACKARD, S.L.

    1998-09-01T23:59:59.000Z

    This document reports the results of a study of cost tools to support the analysis of Operations Other Than War (OOTW). It recommends the continued development of the Department of Defense (DoD) Contingency Operational Support Tool (COST) as the basic cost analysis tool for 00TWS. It also recommends modifications to be included in future versions of COST and the development of an 00TW mission planning tool to supply valid input for costing.

  16. Screening for high-performance piezoelectrics using high-throughput density functional theory

    E-Print Network [OSTI]

    Armiento, Rickard R.

    We present a large-scale density functional theory (DFT) investigation of the ABO3 chemical space in the perovskite crystal structure, with the aim of identifying those that are relevant for forming piezoelectric materials. ...

  17. High-Throughput Methodology for Discovery of Metal-Organic Frameworks with a High

    E-Print Network [OSTI]

    of California, Berkeley Lily Ackerman and Thomas R. Boussie Symyx Technologies, Inc. #12;A Tetrazolate

  18. High throughput parallel backside contacting and periodic texturing for high-efficiency solar cells

    SciTech Connect (OSTI)

    Daniel, Claus; Blue, Craig A.; Ott, Ronald D.

    2014-08-19T23:59:59.000Z

    Disclosed are configurations of long-range ordered features of solar cell materials, and methods for forming same. Some features include electrical access openings through a backing layer to a photovoltaic material in the solar cell. Some features include textured features disposed adjacent a surface of a solar cell material. Typically the long-range ordered features are formed by ablating the solar cell material with a laser interference pattern from at least two laser beams.

  19. High throughput screen for cells with high extracellular metabolite consumption--secretion rates using microfluidic droplets

    E-Print Network [OSTI]

    Wang, Benjamin L. (Benjamin Lu chen)

    2009-01-01T23:59:59.000Z

    Metabolic engineering has contributed significantly to the improvement of strains for the industrial production of various compounds. Traditionally, enzymatic steps closely associated with the product-forming pathway have ...

  20. Ultra-high-aspect-ratio nanofluidic channels for high-throughput biological applications

    E-Print Network [OSTI]

    Mao, Pan

    2009-01-01T23:59:59.000Z

    The development of micro/nanofluidics is expected to be the enabling technology for sample preparation of proteomic biosamples, which has been the bottleneck in proteomics. Most microfabricated nanofluidic channels, such ...

  1. Bayesian Model Selection for High-dimensional High-throughput Data

    E-Print Network [OSTI]

    Joshi, Adarsh

    2012-07-16T23:59:59.000Z

    LIST OF TABLES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . x LIST OF FIGURES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi CHAPTER I INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . 1 II... BAYESIAN HYPOTHESIS TESTING USING TEST STATISTICS 7 2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.3 Bayes? factors based on test statistics: testing...

  2. Wachs Cutter Tooling Station (4495)

    Broader source: Energy.gov (indexed) [DOE]

    purchase, build and install Wachs cutter tooling. The Wachs Cutter Tooling Station is similar to previously operated facility tooling and will utilize an existing hydraulic unit....

  3. High Performance Interconnect System Design for Future Chip Multiprocessors

    E-Print Network [OSTI]

    Wang, Lei

    2013-05-02T23:59:59.000Z

    constraints of power and area, and provide ultra low latencies and high throughput. In this research, we explore different techniques to design high performance NOC. First, existing NOCs mostly use Dimension Order Routing (DOR) to determine the route taken...

  4. Rotary fast tool servo system and methods

    DOE Patents [OSTI]

    Montesanti, Richard C. (Cambridge, MA); Trumper, David L. (Plaistow, NH)

    2007-10-02T23:59:59.000Z

    A high bandwidth rotary fast tool servo provides tool motion in a direction nominally parallel to the surface-normal of a workpiece at the point of contact between the cutting tool and workpiece. Three or more flexure blades having all ends fixed are used to form an axis of rotation for a swing arm that carries a cutting tool at a set radius from the axis of rotation. An actuator rotates a swing arm assembly such that a cutting tool is moved in and away from the lathe-mounted, rotating workpiece in a rapid and controlled manner in order to machine the workpiece. A pair of position sensors provides rotation and position information for a swing arm to a control system. A control system commands and coordinates motion of the fast tool servo with the motion of a spindle, rotating table, cross-feed slide, and in-feed slide of a precision lathe.

  5. Machine tool locator

    DOE Patents [OSTI]

    Hanlon, John A. (Los Alamos, NM); Gill, Timothy J. (Stanley, NM)

    2001-01-01T23:59:59.000Z

    Machine tools can be accurately measured and positioned on manufacturing machines within very small tolerances by use of an autocollimator on a 3-axis mount on a manufacturing machine and positioned so as to focus on a reference tooling ball or a machine tool, a digital camera connected to the viewing end of the autocollimator, and a marker and measure generator for receiving digital images from the camera, then displaying or measuring distances between the projection reticle and the reference reticle on the monitoring screen, and relating the distances to the actual position of the autocollimator relative to the reference tooling ball. The images and measurements are used to set the position of the machine tool and to measure the size and shape of the machine tool tip, and examine cutting edge wear. patent

  6. Certification Status Search Tool

    E-Print Network [OSTI]

    Certification Status Search Tool (SB/DVBE) Illustrated User Manual #12;2 Certification Status Search Tool (SB/DVBE) Rev. 5/14/09 Copyright © 2008 RFP Depot, LLC dba BidSync All Rights Reserved://www.bidsync.com #12;3 Certification Status Search Tool (SB/DVBE) Rev. 5/14/09 Introduction BidSync is a powerful e

  7. BlackboardSectioningTool Course Sectioning The Sectioning Tool

    E-Print Network [OSTI]

    Bou-Zeid, Elie

    sectioning tool: Consult the online help provided within the sectioning tool Call the OIT Help Desk at (609 by those preferences, select Enable/Configure Student Preference Tool. Need help using the BlackboardBlackboardSectioningTool Course Sectioning 1 The Sectioning Tool The Sectioning Tool is a course

  8. Manifold tool guide

    DOE Patents [OSTI]

    Djordjevic, A.

    1983-12-27T23:59:59.000Z

    A tool guide is described that makes possible the insertion of cleaning and/or inspection tools into a manifold pipe that will dislocate and extract the accumulated sediment in such manifold pipes. The tool guide basically comprises a right angled tube (or other angled tube as required) which can be inserted in a large tube and locked into a radially extending cross pipe by adjustable spacer rods and a spring-loaded cone, whereby appropriate cleaning tools can be inserted into the cross pipe for cleaning, inspection, etc. 3 figs.

  9. Manifold tool guide

    DOE Patents [OSTI]

    Djordjevic, A.

    1982-07-08T23:59:59.000Z

    A tool guide that makes possible the insertion of cleaning and/or inspection tools into a manifold pipe that will dislocate and extract the accumulated sediment in such manifold pipes. The tool guide basically comprises a right angled tube (or other angled tube as required) which can be inserted in a large tube and locked into a radially extending cross pipe by adjustable spacer rods and a spring-loaded cone, whereby appropriate cleaning tools can be inserted into to cross pipe for cleaning, inspection, etc.

  10. Manifold tool guide

    DOE Patents [OSTI]

    Djordjevic, Aleksandar (Thousand Oaks, CA)

    1983-12-27T23:59:59.000Z

    A tool guide that makes possible the insertion of cleaning and/or inspection tools into a manifold pipe that will dislocate and extract the accumulated sediment in such manifold pipes. The tool guide basically comprises a right angled tube (or other angled tube as required) which can be inserted in a large tube and locked into a radially extending cross pipe by adjustable spacer rods and a spring-loaded cone, whereby appropriate cleaning tools can be inserted into to cross pipe for cleaning, inspection, etc.

  11. Wireline logging tool catalog

    SciTech Connect (OSTI)

    Verdier, M.

    1986-01-01T23:59:59.000Z

    This book provides discussions on wireline logging tools. The contents are resistivity, radioactivity, acoustic, formation dip and borehold geometry, formation sampling, and auxiliary services.

  12. A direct-write thick-film lithography process for multi-parameter control of tooling in continuous roll-to-roll microcontact printing

    E-Print Network [OSTI]

    Nietner, Larissa F

    2014-01-01T23:59:59.000Z

    Roll-to-roll (R2R) microcontact printing ([mu]CP) aims to transform micron-precision soft lithography in a continuous, large-scale, high-throughput process for large-area surface patterning, flexible electronics and ...

  13. Deployment of a Suite of High-Performance Computational Tools for Multi-scale Multi-physics Simulation of Generation IV Reactors

    SciTech Connect (OSTI)

    Michael Z. Podowski

    2013-01-03T23:59:59.000Z

    The overall objective of this project has been to deploy advanced simulation capabilities for next generation reactor systems utilizing newly available, high-performance computing facilities. The approach includes the following major components: The development of new simulation capabilities using state-of-the-art computer codes of different scales: molecular dynamics (MD) level, DNS (FronTier and PHASTA) and CFD (NPHASE-CMFD); The development of advanced numerical solvers for large-size computational problems; The deployment of a multiple-code computational platform for multiscale simulations of gas/liquid two-phase flow during reactor transients and accidents; and Application of the new computational methodology to study the progression of loss-of-flow accident in sodium fast reactor (SFR).

  14. Leveraging on Easy Java Simulation tool and open source computer simulation library to create interactive digital media for mass customization of high school physics curriculum

    E-Print Network [OSTI]

    Wee, Loo Kang

    2012-01-01T23:59:59.000Z

    This paper highlights the diverse possibilities in the rich community of educators from the Conceptual Learning of Science (CoLoS) and Open Source Physics (OSP) movement to engage, enable and empower educators and students, to create interactive digital media through computer modeling. This concept revolves around a paradigmatic shift towards participatory learning through immersive computer modeling, as opposed to using technology for information transmission. We aim to engage high school educators to professionally develop themselves by creating and customizing simulations possible through Easy Java Simulation (Ejs) and its learning community. Ejs allows educators to be designers of learning environments through modifying source codes of the simulation. Educators can conduct lessons with students' using these interactive digital simulations and rapidly enhance the simulation through changing the source codes personally. Ejs toolkit, its library of simulations and growing community contributed simulation cod...

  15. Fluid sampling tool

    DOE Patents [OSTI]

    Johnston, Roger G. (Los Alamos, NM); Garcia, Anthony R. E. (Espanola, NM); Martinez, Ronald K. (Santa Cruz, NM)

    2001-09-25T23:59:59.000Z

    The invention includes a rotatable tool for collecting fluid through the wall of a container. The tool includes a fluid collection section with a cylindrical shank having an end portion for drilling a hole in the container wall when the tool is rotated, and a threaded portion for tapping the hole in the container wall. A passageway in the shank in communication with at least one radial inlet hole in the drilling end and an opening at the end of the shank is adapted to receive fluid from the container. The tool also includes a cylindrical chamber affixed to the end of the shank opposite to the drilling portion thereof for receiving and storing fluid passing through the passageway. The tool also includes a flexible, deformable gasket that provides a fluid-tight chamber to confine kerf generated during the drilling and tapping of the hole. The invention also includes a fluid extractor section for extracting fluid samples from the fluid collecting section.

  16. OOTW Force Design Tools

    SciTech Connect (OSTI)

    Bell, R.E.; Hartley, D.S.III; Packard, S.L.

    1999-05-01T23:59:59.000Z

    This report documents refined requirements for tools to aid the process of force design in Operations Other Than War (OOTWs). It recommends actions for the creation of one tool and work on other tools relating to mission planning. It also identifies the governmental agencies and commands with interests in each tool, from whom should come the user advisory groups overseeing the respective tool development activities. The understanding of OOTWs and their analytical support requirements has matured to the point where action can be taken in three areas: force design, collaborative analysis, and impact analysis. While the nature of the action and the length of time before complete results can be expected depends on the area, in each case the action should begin immediately. Force design for OOTWs is not a technically difficult process. Like force design for combat operations, it is a process of matching the capabilities of forces against the specified and implied tasks of the operation, considering the constraints of logistics, transport and force availabilities. However, there is a critical difference that restricts the usefulness of combat force design tools for OOTWs: the combat tools are built to infer non-combat capability requirements from combat capability requirements and cannot reverse the direction of the inference, as is required for OOTWs. Recently, OOTWs have played a larger role in force assessment, system effectiveness and tradeoff analysis, and concept and doctrine development and analysis. In the first Quadrennial Defense Review (QDR), each of the Services created its own OOTW force design tool. Unfortunately, the tools address different parts of the problem and do not coordinate the use of competing capabilities. These tools satisfied the immediate requirements of the QDR, but do not provide a long-term cost-effective solution.

  17. Chip breaking system for automated machine tool

    DOE Patents [OSTI]

    Arehart, Theodore A. (Clinton, TN); Carey, Donald O. (Oak Ridge, TN)

    1987-01-01T23:59:59.000Z

    The invention is a rotary selectively directional valve assembly for use in an automated turret lathe for directing a stream of high pressure liquid machining coolant to the interface of a machine tool and workpiece for breaking up ribbon-shaped chips during the formation thereof so as to inhibit scratching or other marring of the machined surfaces by these ribbon-shaped chips. The valve assembly is provided by a manifold arrangement having a plurality of circumferentially spaced apart ports each coupled to a machine tool. The manifold is rotatable with the turret when the turret is positioned for alignment of a machine tool in a machining relationship with the workpiece. The manifold is connected to a non-rotational header having a single passageway therethrough which conveys the high pressure coolant to only the port in the manifold which is in registry with the tool disposed in a working relationship with the workpiece. To position the machine tools the turret is rotated and one of the tools is placed in a material-removing relationship of the workpiece. The passageway in the header and one of the ports in the manifold arrangement are then automatically aligned to supply the machining coolant to the machine tool workpiece interface for breaking up of the chips as well as cooling the tool and workpiece during the machining operation.

  18. Tools used for hand deburring

    SciTech Connect (OSTI)

    Gillespie, L.K.

    1981-03-01T23:59:59.000Z

    This guide is designed to help in quick identification of those tools most commonly used to deburr hand size or smaller parts. Photographs and textual descriptions are used to provide rapid yet detailed information. The data presented include the Bendix Kansas City Division coded tool number, tool description, tool crib in which the tool can be found, the maximum and minimum inventory requirements, the cost of each tool, and the number of the illustration that shows the tool.

  19. Friction stir welding tool

    DOE Patents [OSTI]

    Tolle, Charles R. (Idaho Falls, ID); Clark, Denis E. (Idaho Falls, ID); Barnes, Timothy A. (Ammon, ID)

    2008-04-15T23:59:59.000Z

    A friction stir welding tool is described and which includes a shank portion; a shoulder portion which is releasably engageable with the shank portion; and a pin which is releasably engageable with the shoulder portion.

  20. Sandia Modeling Tool Webinar

    Broader source: Energy.gov [DOE]

    Hosted by the Energy Department and Western Area Power Administration, this webinar will show attendees about what collaborative, stakeholder-driven modeling is and how the modeling tools and process developed by Sandia can be used in Indian Country.

  1. Smart tool holder

    DOE Patents [OSTI]

    Day, Robert Dean (Los Alamos, NM); Foreman, Larry R. (Los Alamos, NM); Hatch, Douglas J. (Los Alamos, NM); Meadows, Mark S. (Boston, MA)

    1998-01-01T23:59:59.000Z

    There is provided an apparatus for machining surfaces to accuracies within the nanometer range by use of electrical current flow through the contact of the cutting tool with the workpiece as a feedback signal to control depth of cut.

  2. UNIX Public Tools

    Broader source: Energy.gov [DOE]

    SATAN, the System Administrator Tool for Analyzing Networks, is a network security analyzer designed byDan Farmerand Wietse Venema. SATAN scans systems connected to the network noting the...

  3. Minds, Brains and Tools

    E-Print Network [OSTI]

    Clark, Andy

    2002-01-01T23:59:59.000Z

    The selected texts for this discussion were two recent pieces by Dennett (Things About Things and Making Tools for Thinking henceforth TAT and MTT respectively) and one oldie-but-goodie (Styles of Mental Representation, ...

  4. ATLAS Distributed Computing Monitoring tools after full 2 years of LHC data taking

    E-Print Network [OSTI]

    Schovancov, J; The ATLAS collaboration

    2012-01-01T23:59:59.000Z

    This paper details variety of Monitoring tools used within the ATLAS Distributed Computing during the first 2 years of LHC data taking. We discuss tools used to monitor data processing from the very first steps performed at the Tier-0 facility at CERN after data is read out of the ATLAS detector, through data transfers to the ATLAS computing centers distributed world-wide. We present an overview of monitoring tools used daily to track ATLAS Distributed Computing activities ranging from network performance and data transfers throughput, through data processing and readiness of the computing services at the ATLAS computing centers, to the reliability and usability of the ATLAS computing centers. Described tools provide monitoring for issues of different level of criticality: from spotting issues with the instant online monitoring to the long-term accounting information.

  5. Computational Tools to Accelerate Commercial Development

    SciTech Connect (OSTI)

    Miller, David C.

    2013-01-01T23:59:59.000Z

    The goals of the work reported are: to develop new computational tools and models to enable industry to more rapidly develop and deploy new advanced energy technologies; to demonstrate the capabilities of the CCSI Toolset on non-proprietary case studies; and to deploy the CCSI Toolset to industry. Challenges of simulating carbon capture (and other) processes include: dealing with multiple scales (particle, device, and whole process scales); integration across scales; verification, validation, and uncertainty; and decision support. The tools cover: risk analysis and decision making; validated, high-fidelity CFD; high-resolution filtered sub-models; process design and optimization tools; advanced process control and dynamics; process models; basic data sub-models; and cross-cutting integration tools.

  6. SOFTWARE Open Access The HTS barcode checker pipeline, a tool for

    E-Print Network [OSTI]

    Kaski, Samuel

    of trade in endangered species, and can aid in safeguarding these species from extinction in the wild traded species from high-throughput sequencing data Youri Lammers1 , Tamara Peelen2 , Rutger A Vos1 contain parts of species protected by the Convention on International Trade in Endangered Species of Wild

  7. Quaternary Borate Deposits As A Geothermal Exploration Tool In...

    Open Energy Info (EERE)

    Borate Deposits As A Geothermal Exploration Tool In The Great Basin Abstract A close spatial relationship exists between Quaternary borate deposits and moderate to high...

  8. High Througput Combinatorial Techniques in Hydrogen Storage Materials...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and surface area measurements (high-throughput techniques need development). 5. Aerogels Page 2 of 5 Synthesis is based on standard sol-gel processes and should be similar to...

  9. Program Development Tools and Infrastructures

    SciTech Connect (OSTI)

    Schulz, M

    2012-03-12T23:59:59.000Z

    Exascale class machines will exhibit a new level of complexity: they will feature an unprecedented number of cores and threads, will most likely be heterogeneous and deeply hierarchical, and offer a range of new hardware techniques (such as speculative threading, transactional memory, programmable prefetching, and programmable accelerators), which all have to be utilized for an application to realize the full potential of the machine. Additionally, users will be faced with less memory per core, fixed total power budgets, and sharply reduced MTBFs. At the same time, it is expected that the complexity of applications will rise sharply for exascale systems, both to implement new science possible at exascale and to exploit the new hardware features necessary to achieve exascale performance. This is particularly true for many of the NNSA codes, which are large and often highly complex integrated simulation codes that push the limits of everything in the system including language features. To overcome these limitations and to enable users to reach exascale performance, users will expect a new generation of tools that address the bottlenecks of exascale machines, that work seamlessly with the (set of) programming models on the target machines, that scale with the machine, that provide automatic analysis capabilities, and that are flexible and modular enough to overcome the complexities and changing demands of the exascale architectures. Further, any tool must be robust enough to handle the complexity of large integrated codes while keeping the user's learning curve low. With the ASC program, in particular the CSSE (Computational Systems and Software Engineering) and CCE (Common Compute Environment) projects, we are working towards a new generation of tools that fulfill these requirements and that provide our users as well as the larger HPC community with the necessary tools, techniques, and methodologies required to make exascale performance a reality.

  10. Boosted top: experimental tools overview

    E-Print Network [OSTI]

    Emanuele Usai; for the ATLAS; CMS Collaborations

    2015-01-05T23:59:59.000Z

    An overview of tools and methods for the reconstruction of high-boost top quark decays at the LHC is given in this report. The focus is on hadronic decays, in particular an overview of the current status of top quark taggers in physics analyses is presented. The most widely used jet substructure techniques, normally used in combination with top quark taggers, are reviewed. Special techniques to treat pileup in large cone jets are described, along with a comparison of the performance of several boosted top quark reconstruction techniques.

  11. Figure 2 Analysis Tool Interface Level-1 / PBBT Analysis Tool

    E-Print Network [OSTI]

    Figure 2 ­ Analysis Tool Interface Level-1 / PBBT Analysis Tool Introduction The Level-1/PBBT Analysis Tool (LPAT) was designed to assist in the analysis of North American Standard Level-1 Inspection. The data incorporated into the tool includes the results of Level-1 inspections with accompanying PBBT test

  12. Drum lid removal tool

    DOE Patents [OSTI]

    Pella, Bernard M. (Martinez, GA); Smith, Philip D. (North Augusta, SC)

    2010-08-24T23:59:59.000Z

    A tool for removing the lid of a metal drum wherein the lid is clamped over the drum rim without protruding edges, the tool having an elongated handle with a blade carried by an angularly positioned holder affixed to the midsection of the handle, the blade being of selected width to slice between lid lip and the drum rim and, when the blade is so positioned, upward motion of the blade handle will cause the blade to pry the lip from the rim and allow the lid to be removed.

  13. PDSF Software and Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLas Conchas recoveryLaboratorySpeedingOptimizingTools Software and Tools Chos Chos is used to

  14. A Deeply Pipelined CABAC Decoder for HEVC Supporting Level 6.2 High-tier Applications

    E-Print Network [OSTI]

    Chen, Yu-Hsin

    High Efficiency Video Coding (HEVC) is the latest video coding standard that specifies video resolutions up to 8K Ultra-HD (UHD) at 120 fps to support the next decade of video applications. This results in high-throughput ...

  15. Smart tool holder

    DOE Patents [OSTI]

    Day, R.D.; Foreman, L.R.; Hatch, D.J.; Meadows, M.S.

    1998-09-08T23:59:59.000Z

    There is provided an apparatus for machining surfaces to accuracies within the nanometer range by use of electrical current flow through the contact of the cutting tool with the workpiece as a feedback signal to control depth of cut. 3 figs.

  16. 2005 International Conference on Wireless Networks, Communications and Mobile Computing Improving TCP Throughput over Lossy Links Using

    E-Print Network [OSTI]

    Atiquzzaman, Mohammed

    TCP Throughput over Lossy Links Using Protocol-Level Speculations Haowei Bai Honeywell Labs 3660- The degradation of Transport Control Protocol (TCP) throughput in networks with lossy links is mainly due to processor performance degradation due to control hazards in CPU design. First, two types of loss events

  17. Optimization of Comminution Circuit Throughput and Product Size Distribution by Simulation and Control

    SciTech Connect (OSTI)

    S.K. Kawatra; T.C. Eisele; T. Weldum; D. Larsen; R. Mariani; J. Pletka

    2005-07-01T23:59:59.000Z

    The goal of this project was to improve energy efficiency of industrial crushing and grinding operations (comminution). Mathematical models of the comminution process were used to study methods for optimizing the product size distribution, so that the amount of excessively fine material produced could be minimized. The goal was to save energy by reducing the amount of material that was ground below the target size, while simultaneously reducing the quantity of materials wasted as ''slimes'' that were too fine to be useful. Extensive plant sampling and mathematical modeling of the grinding circuits was carried out to determine how to correct this problem. The approaches taken included (1) Modeling of the circuit to determine process bottlenecks that restrict flowrates in one area while forcing other parts of the circuit to overgrind the material; (2) Modeling of hydrocyclones to determine the mechanisms responsible for retaining fine, high-density particles in the circuit until they are overground, and improving existing models to accurately account for this behavior; and (3) Evaluation of the potential of advanced technologies to improve comminution efficiency and produce sharper product size distributions with less overgrinding. The mathematical models were used to simulate novel circuits for minimizing overgrinding and increasing throughput, and it is estimated that a single plant grinding 15 million tons of ore per year saves up to 82.5 million kWhr/year, or 8.6 x 10{sup 11} BTU/year. Implementation of this technology in the midwestern iron ore industry, which grinds an estimated 150 million tons of ore annually to produce over 50 million tons of iron ore concentrate, would save an estimated 1 x 10{sup 13} BTU/year.

  18. Throughput-driven design of networks-on-chip

    E-Print Network [OSTI]

    Sunkam Ramanujam, Rohit

    2011-01-01T23:59:59.000Z

    Symposium on Computer Architecture, ISCA 06, pages 130 [18]on High Performance Computer Architecture, HPCA 08, pagessymposium on Computer architecture, ISCA 07, pages 138149,

  19. Pneumatic soil removal tool

    DOE Patents [OSTI]

    Neuhaus, J.E.

    1992-10-13T23:59:59.000Z

    A soil removal tool is provided for removing radioactive soil, rock and other debris from the bottom of an excavation, while permitting the operator to be located outside of a containment for that excavation. The tool includes a fixed jaw, secured to one end of an elongate pipe, which cooperates with a movable jaw pivotably mounted on the pipe. Movement of the movable jaw is controlled by a pneumatic cylinder mounted on the pipe. The actuator rod of the pneumatic cylinder is connected to a collar which is slidably mounted on the pipe and forms part of the pivotable mounting assembly for the movable jaw. Air is supplied to the pneumatic cylinder through a handle connected to the pipe, under the control of an actuator valve mounted on the handle, to provide movement of the movable jaw. 3 figs.

  20. Pneumatic soil removal tool

    DOE Patents [OSTI]

    Neuhaus, John E. (Newport News, VA)

    1992-01-01T23:59:59.000Z

    A soil removal tool is provided for removing radioactive soil, rock and other debris from the bottom of an excavation, while permitting the operator to be located outside of a containment for that excavation. The tool includes a fixed jaw, secured to one end of an elongate pipe, which cooperates with a movable jaw pivotably mounted on the pipe. Movement of the movable jaw is controlled by a pneumatic cylinder mounted on the pipe. The actuator rod of the pneumatic cylinder is connected to a collar which is slidably mounted on the pipe and forms part of the pivotable mounting assembly for the movable jaw. Air is supplied to the pneumatic cylinder through a handle connected to the pipe, under the control of an actuator valve mounted on the handle, to provide movement of the movable jaw.

  1. Fluid blade disablement tool

    DOE Patents [OSTI]

    Jakaboski, Juan-Carlos (Albuquerque, NM); Hughs, Chance G. (Albuquerque, NM); Todd, Steven N. (Rio Rancho, NM)

    2012-01-10T23:59:59.000Z

    A fluid blade disablement (FBD) tool that forms both a focused fluid projectile that resembles a blade, which can provide precision penetration of a barrier wall, and a broad fluid projectile that functions substantially like a hammer, which can produce general disruption of structures behind the barrier wall. Embodiments of the FBD tool comprise a container capable of holding fluid, an explosive assembly which is positioned within the container and which comprises an explosive holder and explosive, and a means for detonating. The container has a concavity on the side adjacent to the exposed surface of the explosive. The position of the concavity relative to the explosive and its construction of materials with thicknesses that facilitate inversion and/or rupture of the concavity wall enable the formation of a sharp and coherent blade of fluid advancing ahead of the detonation gases.

  2. Java Vertexing Tools

    SciTech Connect (OSTI)

    Strube, Jan; /Oregon U.; Graf, Norman; /SLAC

    2006-03-03T23:59:59.000Z

    This document describes the implementation of the topological vertex finding algorithm ZVTOP within the org.lcsim reconstruction and analysis framework. At the present date, Java vertexing tools allow users to perform topological vertexing on tracks that have been obtained from a Fast MC simulation. An implementation that will be able to handle fully reconstructed events is being designed from the ground up for longevity and maintainability.

  3. Fluid sampling tool

    DOE Patents [OSTI]

    Garcia, A.R.; Johnston, R.G.; Martinez, R.K.

    1999-05-25T23:59:59.000Z

    A fluid sampling tool is described for sampling fluid from a container. The tool has a fluid collecting portion which is drilled into the container wall, thereby affixing it to the wall. The tool may have a fluid extracting section which withdraws fluid collected by the fluid collecting section. The fluid collecting section has a fluted shank with an end configured to drill a hole into a container wall. The shank has a threaded portion for tapping the borehole. The shank is threadably engaged to a cylindrical housing having an inner axial passageway sealed at one end by a septum. A flexible member having a cylindrical portion and a bulbous portion is provided. The housing can be slid into an inner axial passageway in the cylindrical portion and sealed to the flexible member. The bulbous portion has an outer lip defining an opening. The housing is clamped into the chuck of a drill, the lip of the bulbous section is pressed against a container wall until the shank touches the wall, and the user operates the drill. Wall shavings (kerf) are confined in a chamber formed in the bulbous section as it folds when the shank advances inside the container. After sufficient advancement of the shank, an o-ring makes a seal with the container wall. 6 figs.

  4. Frequency Response Analysis Tool

    SciTech Connect (OSTI)

    Etingov, Pavel V.; Kosterev, Dmitry; Dai, T.

    2014-12-31T23:59:59.000Z

    Frequency response has received a lot of attention in recent years at the national level, which culminated in the development and approval of North American Electricity Reliability Corporation (NERC) BAL-003-1 Frequency Response and Frequency Bias Setting Reliability Standard. This report is prepared to describe the details of the work conducted by Pacific Northwest National Laboratory (PNNL) in collaboration with the Bonneville Power Administration and Western Electricity Coordinating Council (WECC) Joint Synchronized Information Subcommittee (JSIS) to develop a frequency response analysis tool (FRAT). The document provides the details on the methodology and main features of the FRAT. The tool manages the database of under-frequency events and calculates the frequency response baseline. Frequency response calculations are consistent with frequency response measure (FRM) in NERC BAL-003-1 for an interconnection and balancing authority. The FRAT can use both phasor measurement unit (PMU) data, where available, and supervisory control and data acquisition (SCADA) data. The tool is also capable of automatically generating NERC Frequency Response Survey (FRS) forms required by BAL-003-1 Standard.

  5. Exploiting concurrency to improve latency and throughput in a hybrid storage system

    E-Print Network [OSTI]

    Reddy, Narasimha

    Exploiting concurrency to improve latency and throughput in a hybrid storage system Xiaojian Wu, A the problem of how to improve the performance of hybrid storage system employing solid state disks and hard parallelism in the storage system effectively to improve through- put and latency simultaneously. We

  6. Area and Throughput Trade-Offs in the Design of Pipelined Discrete Wavelet Transform Architectures

    E-Print Network [OSTI]

    Boyer, Edmond

    Area and Throughput Trade-Offs in the Design of Pipelined Discrete Wavelet Transform Architectures wavelet transform (DWT) as a linear space-to-frequency transform of the image domain in an irreversible compression. This irreversible discrete wavelet transform is implemented by FIR filter using 9/7 Daubechies

  7. Throughput and Ergodic Capacity of Wireless Energy Harvesting Based DF Relaying Network

    E-Print Network [OSTI]

    Zhou, Xiangyun "Sean"

    -to-point communication systems and studied rate-energy trade-off assuming single-input-single-output (SISO) [1], [3Throughput and Ergodic Capacity of Wireless Energy Harvesting Based DF Relaying Network Ali A-and-forward (DF) relaying network based on wireless energy harvesting. The energy constrained relay node first

  8. MIMO Ad Hoc Networks: Medium Access Control, Saturation Throughput and Optimal Hop Distance

    E-Print Network [OSTI]

    Reisslein, Martin

    1 MIMO Ad Hoc Networks: Medium Access Control, Saturation Throughput and Optimal Hop Distance Ming in mobile ad hoc networks. Specifically, we focus on ad hoc networks where the spa- tial diversity technique technique can enhance the performance of mobile ad hoc networks significantly. Key words: ad hoc networks

  9. Cherish every Joule: Maximizing throughput with an eye on network-wide energy consumption

    E-Print Network [OSTI]

    Hou, Y. Thomas

    Cherish every Joule: Maximizing throughput with an eye on network-wide energy consumption Canming: {jcm, yshi, thou, wjlou}@vt.edu Abstract Conserving network-wide energy consumption is becoming of wireless networks, the concern of energy consumption is becoming in- creasingly important for network

  10. On Throughput Maximization of Time Division Multiple Access with Energy Harvesting Users

    E-Print Network [OSTI]

    Dai, Huaiyu

    1 On Throughput Maximization of Time Division Multiple Access with Energy Harvesting Users Juan Liu a multiple access channel, where multiple users equipped with energy harvesting batteries com- municate assumed that the users' energy harvesting processes and storage status are known to all the users before

  11. Short-Term Throughput Maximization for Battery Limited Energy Harvesting Nodes

    E-Print Network [OSTI]

    Yener, Aylin

    for energy recharge. Under the assumption of an increasing concave power-rate relationship, the short completion time of a given amount of data were found for an energy harvesting node under the assumptionShort-Term Throughput Maximization for Battery Limited Energy Harvesting Nodes Kaya Tutuncuoglu

  12. A Framework for Throughput and Energy Efficiency in Mobile ad Hoc Networks

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    throughput and energy consumption - while maintaining connectivity. As an application, we evaluate two well on exhaustible power sources, such as batteries, and hence have strict requirements on the energy consumption networks which allows us to compare the average energy and time cost of different networks but exhibiting

  13. Minimizing the Energy Cost of Throughput in a Linear Pipeline by Opportunistic Time Borrowing

    E-Print Network [OSTI]

    Pedram, Massoud

    Minimizing the Energy Cost of Throughput in a Linear Pipeline by Opportunistic Time Borrowing a technique to optimize the energy-delay product of a synchronous linear pipeline circuit with dynamic error and clock frequency of the design by exploiting slacks that are present in various stages of the pipeline

  14. Joint Power Control and Link Scheduling in Wireless Networks for Throughput Optimization

    E-Print Network [OSTI]

    Huang, Jianwei

    Joint Power Control and Link Scheduling in Wireless Networks for Throughput Optimization Liqun Fu formulate the general joint link scheduling and power control problem as an in- teger linear programming optimality. Index Terms--scheduling, power control, SINR constraints. I. INTRODUCTION Due to their unconfined

  15. Performance evaluation of bound diamond ring tools

    SciTech Connect (OSTI)

    Piscotty, M.A.; Taylor, J.S.; Blaedel, K.L.

    1995-07-14T23:59:59.000Z

    LLNL is collaborating with the Center for Optics Manufacturing (COM) and the American Precision Optics Manufacturers Association (APOMA) to optimize bound diamond ring tools for the spherical generation of high quality optical surfaces. An important element of this work is establishing an experimentally-verified link between tooling properties and workpiece quality indicators such as roughness, subsurface damage and removal rate. In this paper, we report on a standardized methodology for assessing ring tool performance and its preliminary application to a set of commercially-available wheels. Our goals are to (1) assist optics manufacturers (users of the ring tools) in evaluating tools and in assessing their applicability for a given operation, and (2) provide performance feedback to wheel manufacturers to help optimize tooling for the optics industry. Our paper includes measurements of wheel performance for three 2-4 micron diamond bronze-bond wheels that were supplied by different manufacturers to nominally- identical specifications. Preliminary data suggests that the difference in performance levels among the wheels were small.

  16. CIMFUELS: Commercial practice--tools vs. solutions

    SciTech Connect (OSTI)

    Latour, P.R.

    1997-03-01T23:59:59.000Z

    Continuing the them of CIMFUELS` recent editorials on good management practice, the nature of commercial offerings and practices between CIM providers and their fuel and petrochemical operating company customers and clients also warrants discussion. The commercial practices of the CIMFUELS business in this unstructured, fast changing, high technology global business has suffered unduly from inadequate distinction between tools and solutions.

  17. High Efficiency, Low Cost Solar Cells Manufactured Using 'Silicon Ink' on Thin Crystalline Silicon Wafers

    SciTech Connect (OSTI)

    Antoniadis, H.

    2011-03-01T23:59:59.000Z

    Reported are the development and demonstration of a 17% efficient 25mm x 25mm crystalline Silicon solar cell and a 16% efficient 125mm x 125mm crystalline Silicon solar cell, both produced by Ink-jet printing Silicon Ink on a thin crystalline Silicon wafer. To achieve these objectives, processing approaches were developed to print the Silicon Ink in a predetermined pattern to form a high efficiency selective emitter, remove the solvents in the Silicon Ink and fuse the deposited particle Silicon films. Additionally, standard solar cell manufacturing equipment with slightly modified processes were used to complete the fabrication of the Silicon Ink high efficiency solar cells. Also reported are the development and demonstration of a 18.5% efficient 125mm x 125mm monocrystalline Silicon cell, and a 17% efficient 125mm x 125mm multicrystalline Silicon cell, by utilizing high throughput Ink-jet and screen printing technologies. To achieve these objectives, Innovalight developed new high throughput processing tools to print and fuse both p and n type particle Silicon Inks in a predetermined pat-tern applied either on the front or the back of the cell. Additionally, a customized Ink-jet and screen printing systems, coupled with customized substrate handling solution, customized printing algorithms, and a customized ink drying process, in combination with a purchased turn-key line, were used to complete the high efficiency solar cells. This development work delivered a process capable of high volume producing 18.5% efficient crystalline Silicon solar cells and enabled the Innovalight to commercialize its technology by the summer of 2010.

  18. SNP Calling Using Genotype Model Selection on High-Throughput Sequencing Data

    E-Print Network [OSTI]

    Murillo, Gabriel Hiroshi

    2012-01-01T23:59:59.000Z

    10, March 2009. [35] Heng Li. Fastq format specification.Accessed: 10/16/2012. [36] Heng Li. Pileup format. http://Ac- cessed: 10/16/2012. [37] Heng Li. Mathematical notes on

  19. Attendees list from the U.S. Department of Energy's High Throughput...

    Broader source: Energy.gov (indexed) [DOE]

    Larry Blair DOE Tom Boussie Symyx Technologies Bob Bowman JPL Larry Cook NIST Alan Cooper Air Products Kristin Deason Sentech Pete DeSanto Air Products R. Greg Downing NIST Mike...

  20. Improving the Yeast Three-Hybrid System for High-Throughput Target Discovery

    E-Print Network [OSTI]

    Bailey, Kyle

    2011-05-27T23:59:59.000Z

    of the requirements for the degree of Master of Science. ________________________________ Chairperson Dr. Blake R. Peterson ________________________________ Dr. Gary Grunewald ________________________________ Dr.... Gary Grunewald and Dr. Jeff Krise, and my research advisor Dr. Blake Peterson. Additional thanks to Dr. Peterson for guidance, patience, and support over the past years. v TABLE OF CONTENTS ABSTRACT...

  1. High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury

    SciTech Connect (OSTI)

    Wills, Lauren P. [MitoHealth Inc., Charleston, SC 29403 (United States); Beeson, Gyda C.; Trager, Richard E.; Lindsey, Christopher C. [Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425 (United States); Beeson, Craig C. [MitoHealth Inc., Charleston, SC 29403 (United States); Peterson, Yuri K. [Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425 (United States); Schnellmann, Rick G., E-mail: schnell@musc.edu [Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425 (United States); Ralph H. Johnson VA Medical Center, Charleston, SC 29401 (United States)

    2013-10-15T23:59:59.000Z

    Many environmental chemicals and drugs negatively affect human health through deleterious effects on mitochondrial function. Currently there is no chemical library of mitochondrial toxicants, and no reliable methods for predicting mitochondrial toxicity. We hypothesized that discrete toxicophores defined by distinct chemical entities can identify previously unidentified mitochondrial toxicants. We used a respirometric assay to screen 1760 compounds (5 ?M) from the LOPAC and ChemBridge DIVERSet libraries. Thirty-one of the assayed compounds decreased uncoupled respiration, a stress test for mitochondrial dysfunction, prior to a decrease in cell viability and reduced the oxygen consumption rate in isolated mitochondria. The mitochondrial toxicants were grouped by chemical similarity and two clusters containing four compounds each were identified. Cheminformatic analysis of one of the clusters identified previously uncharacterized mitochondrial toxicants from the ChemBridge DIVERSet. This approach will enable the identification of mitochondrial toxicants and advance the prediction of mitochondrial toxicity for both drug discovery and risk assessment. - Highlights: Respirometric assay conducted in RPTC to create mitochondrial toxicant database. Chemically similar mitochondrial toxicants aligned as mitochondrial toxicophores Mitochondrial toxicophore identifies five novel mitochondrial toxicants.

  2. Polymer microfluidic device for high-throughput single-cell encapsulation, lysis, and biological assay

    E-Print Network [OSTI]

    Brackbill, Timothy Peter

    2012-01-01T23:59:59.000Z

    rheology through microfluidics, Advanced Materials, vol.Berthier and P. Silberzan, Microfluidics for Biotechnology.A. P. Lee, Droplet microfluidics, Lab on a Chip, vol. 8,

  3. High Throughput Identification, Purification and Structural Characterization of Water Soluble Protein Complexes in Desulfovibrio vulgaris

    SciTech Connect (OSTI)

    Dong,, Ming; Han, Bong-Gyoon; Liu, Hui-Hai; Malik, J.; Geller, Jil; Yang, Li; Choi, M.; Chandonia, John-Marc; Arbelaez, Pablo; Sterling, H. J.; Typke, Dieter; Shatsky, Max; Brenner, Steve; Fisher, Susan; Williams, Evan; Szakal, Evelin; Allen, S.; Hall, S. C.; Hazen, Terry; Witkowska, H. E.; Jin, Jiming; Glaeser, Robert; Biggin, Mark

    2010-05-17T23:59:59.000Z

    Our scheme for the tagless purification of water soluble complexes. 10 g of protein from a crude bacterial extract is first fractionated by ammonium sulfate precipitation and then by a series of chromatographic steps: anion exchange (IEX), hydrophobic interaction (HIC), and finally size exclusion (Gel Filtration). Fractions from the last chromatography step are trypsin digested and peptides labeled with iTRAQ reagents to allow multiplexing and quantitation during mass spectrometric analysis. Elution profiles of identified proteins are then subjected to clustering analysis.

  4. Improved High Maximum Stable Throughput FCFS Tree Algorithms with Interference Cancellation

    E-Print Network [OSTI]

    Middelheimlaan 1 B-2020 Antwerp, Belgium ABSTRACT Tree algorithms form a well researched class of collision res-detection mechanisms). In point-to- multipoint access networks, such as DVB-RCS satellite net- works and hybrid, Mikhailov and Vvedenskaya [12]. These algorithms were the first to have a provable MST above zero. Afterward

  5. High-throughput genomic analysis of virulence and resistance mechanisms among microbial pathogens

    E-Print Network [OSTI]

    Tewhey, Ryan Stephen

    2012-01-01T23:59:59.000Z

    al. (2010). Evolution of MRSA during hospital transmissionphylogenetic tree CA-MRSA isolates and the reference strainand antibiotic resistance costs by MRSA. The ISME journal 4,

  6. Using Clustering Techniques to Improve Hit Selection in High-Throughput Screening

    E-Print Network [OSTI]

    Makarenkov, Vladimir

    control. This makes the correct identification of active compounds quite difficult. The incoherencies and Makarenkov,7 and Makarenkov et al.8,9 Another factor that influences the identification of active compounds plate or in the bulk of the data). This method is not statistically justified and can lead to some

  7. Identification of GPR65, a novel regulator of matrix metalloproteinases using high through-put screening

    SciTech Connect (OSTI)

    Xu, Hongbo; Chen, Xiaohong; Huang, Junwei [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China)] [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China); Deng, Weiwei [Functional Genomics Group, Chinese National Human Genome Center (CHGB) at Beijing (China)] [Functional Genomics Group, Chinese National Human Genome Center (CHGB) at Beijing (China); Zhong, Qi [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China)] [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China); Yue, Changli [Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing (China)] [Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing (China); Wang, Pingzhang, E-mail: wangpzh@bjmu.edu.cn [Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University Center for Human Disease Genomics, Key Laboratory of Medical Immunology, Ministry of Health (China) [Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Peking University Center for Human Disease Genomics, Key Laboratory of Medical Immunology, Ministry of Health (China); Functional Genomics Group, Chinese National Human Genome Center (CHGB) at Beijing (China); Huang, Zhigang, E-mail: enthuangzhigang@sohu.com [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China)] [Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery, Beijing (China)

    2013-06-21T23:59:59.000Z

    Highlights: A novel mechanism of MMP3 regulation by proton-sensing G-protein-coupled receptors was defined. GPR65 was identified to induce the MMP3 expression. GPR65 mediated MMP induction under acidic conditions. AP-1 binding site in MMP3 promoter was crucial for MMP3 induction. GPR65 overexpression can accelerate the invision of A549 cells. -- Abstract: Matrix metalloproteinases (MMPs) are over-expressed in nearly all cancers. To study novel regulatory factors of MMP expression in head and neck cancer (HNC), we screened a total of 636 candidate genes encoding putative human transmembrane proteins using MMP promoter reporter in a dual luciferase assay system. Three genes GPR65, AXL and TNFRSF10B dramatically activated the induction of MMP3 expression. The induction of MMP expression by GPR65 was further confirmed in A549 and/or FaDu cells. GPR65 mediated MMP induction under acidic conditions. The AP-1 binding site in MMP3 promoter was crucial for MMP3 induction. Moreover, the A549 cells infected by recombinant adenovirus of GPR65 showed accelerated cell invasion. In conclusion, we validate that GPR65 is vital regulatory genes upstream of MMP3, and define a novel mechanism of MMP3 regulation by proton-sensing G-protein-coupled receptors.

  8. A high-throughput, near-saturating screen for type III effector genes from Pseudomonas syringae

    E-Print Network [OSTI]

    Dangl, Jeff

    criteria defined 29 type III proteins from P. syringae pv. tomato, and 19 from P. syringae pv. phaseolicola [disease resistance (R) pro- teins], a battery of host responses is triggered, including localized

  9. Characterization and High Throughput Analysis of Metal Hydrides for Hydrogen Storage

    E-Print Network [OSTI]

    Barcelo, Steven James

    2009-01-01T23:59:59.000Z

    Metal Hydrides for Hydrogen Storage by Steven James BarceloMetal Hydrides for Hydrogen Storage by Steven James BarceloCo-chair Efficient hydrogen storage is required for fuel

  10. Characterization and High Throughput Analysis of Metal Hydrides for Hydrogen Storage.

    E-Print Network [OSTI]

    Barcelo, Steven James

    2009-01-01T23:59:59.000Z

    ??Efficient hydrogen storage is required for fuel cell vehicles to be competitive with those driven by internal combustion engines. Current methods of storage such as (more)

  11. MCAM: Multiple Clustering Analysis Methodology for Deriving Hypotheses and Insights from High-Throughput Proteomic Datasets

    E-Print Network [OSTI]

    Naegle, Kristen Marie

    Advances in proteomic technologies continue to substantially accelerate capability for generating experimental data on protein levels, states, and activities in biological samples. For example, studies on receptor tyrosine ...

  12. Low-damage high-throughput grazing-angle sputter deposition on graphene

    SciTech Connect (OSTI)

    Chen, C.-T.; Gajek, M.; Raoux, S. [IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598 (United States); Casu, E. A. [IBM Thomas J. Watson Research Center, Yorktown Heights, New York 10598 (United States); Politecnico di Torino, Turin 10129 (Italy)

    2013-07-15T23:59:59.000Z

    Despite the prevalence of sputter deposition in the microelectronics industry, it has seen very limited applications for graphene electronics. In this letter, we report systematic investigation of the sputtering induced damages in graphene and identify the energetic sputtering gas neutrals as the primary cause of graphene disorder. We further demonstrate a grazing-incidence sputtering configuration that strongly suppresses fast neutral bombardment and retains graphene structure integrity, creating considerably lower damage than electron-beam evaporation. Such sputtering technique yields fully covered, smooth thin dielectric films, highlighting its potential for contact metals, gate oxides, and tunnel barriers fabrication in graphene device applications.

  13. Development and Application of a High Throughput Methodology to Characterize and Formulate Protein-Based Therapeutics

    E-Print Network [OSTI]

    Hu, Lei

    2012-12-31T23:59:59.000Z

    simultaneously, including UV absorption, light scattering, and near- and far- UV CD by employing a multimodal spectrometer (Chapter 2). Fluorescence spectral data are also collected on the same instrument although not simultaneously. The method is developed...

  14. High-Throughput In Situ Parametric Studies of Cytochrome P450 Catalysis

    E-Print Network [OSTI]

    Traylor, Matthew John

    2010-01-01T23:59:59.000Z

    of data quality in pharmaceutical industry, J Chromatogr Agenerally useful to pharmaceutical industries to facilitateimportance to the pharmaceutical industry in the metabolic

  15. High-Throughput Screen of Natural Product Libraries for Hsp90 Inhibitors

    E-Print Network [OSTI]

    Davenport, Jason; Blach, Maurie; Galam, Lakshmi; Girgis, Antwan; Hall, Jessica; Blagg, Brian S. J.; Matts, Robert L.

    2014-03-03T23:59:59.000Z

    and negative controls to make the calculation. Robust statistics [32], which minimizes the effects of outliers on the statistical analysis, were used to calculate the median, robust standard deviation (rSD) and the robust percent coefficient of variance (%r....041 13 rSD). The Microsource compounds were part of a previously published screen [29] that had a Z-factor of 0.62 0.09. The Z-factors for the TimTec and Analyticon screens were 0.77 0.18 and 0.64 0.14, respectively. The %rCV for the screens...

  16. Integrated microfluidic device for single-cell high throughput screening in dynamic gene expression analysis

    E-Print Network [OSTI]

    Hui, Lawrence Kwan Yeung

    2008-01-01T23:59:59.000Z

    iv v vii ix x xii 3.3.1 Gradient Generation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

  17. Antibody-functionalized nanoporous surfaces enable high throughput specific cell capture

    E-Print Network [OSTI]

    Mittal, Sukant

    2012-01-01T23:59:59.000Z

    Adhesion-based cell capture on surfaces in microfluidic devices forms the basis of numerous biomedical diagnostics and in vitro assays. Solid surface microfluidic platforms have been widely explored for biomedical diagnostics ...

  18. Estimating enrichment of repetitive elements from high-throughput sequence data

    E-Print Network [OSTI]

    Luquette, Lovelace J.

    We describe computational methods for analysis of repetitive elements from short-read sequencing data, and apply them to study histone modifications associated with the repetitive elements in human and mouse cells. Our ...

  19. PVD synthesis and high-throughput property characterization of Ni?Fe?Cr alloy libraries

    SciTech Connect (OSTI)

    Rar, A.; Frafjord, J.J.; Fowlkes, Jason D.; Specht, E.D.; Rack, P.D.; Santella, M.L.; Bei, H.; George, E.P.; Pharr, G.M. (Tennessee-K); (Tennessee-K); (ORNL)

    2010-11-10T23:59:59.000Z

    Three methods of alloy library synthesis, thick-layer deposition followed by interdiffusion, composition-spread codeposition and electron-beam melting of thick deposited layers, have been applied to Ni-Fe-Cr ternary and Ni-Cr binary alloys. Structural XRD mapping and mechanical characterization by means of nanoindentation have been used to characterize the properties of the libraries. The library synthesis methods are compared from the point of view of the structural and mechanical information they can provide.

  20. Automated high-throughput flow-through real-time diagnostic system

    DOE Patents [OSTI]

    Regan, John Frederick

    2012-10-30T23:59:59.000Z

    An automated real-time flow-through system capable of processing multiple samples in an asynchronous, simultaneous, and parallel fashion for nucleic acid extraction and purification, followed by assay assembly, genetic amplification, multiplex detection, analysis, and decontamination. The system is able to hold and access an unlimited number of fluorescent reagents that may be used to screen samples for the presence of specific sequences. The apparatus works by associating extracted and purified sample with a series of reagent plugs that have been formed in a flow channel and delivered to a flow-through real-time amplification detector that has a multiplicity of optical windows, to which the sample-reagent plugs are placed in an operative position. The diagnostic apparatus includes sample multi-position valves, a master sample multi-position valve, a master reagent multi-position valve, reagent multi-position valves, and an optical amplification/detection system.

  1. High throughput 3D optical microscopy : from image cytometry to endomicroscopy

    E-Print Network [OSTI]

    Choi, Heejin

    2014-01-01T23:59:59.000Z

    Optical microscopy is an imaging technique that allows morphological mapping of intracellular structures with submicron resolution. More importantly, optical microscopy is a technique that can readily provide images with ...

  2. SUPPLEMENTAL INFORMATION Treatability of Complex Effluents in High-Throughput and Bench Scale Microbial

    E-Print Network [OSTI]

    . The efficiency was calculated using only recovered hydrogen and combined hydrogen and methane, using the heat of combustion to calculate the energy contained in the gas. Figure S13. Open circuit gas production and COD

  3. A high-throughput in vivo micronucleus assay for genome instability screening in mice

    E-Print Network [OSTI]

    Balmus, Gabriel; Karp, Natasha A; Ng, Bee Ling; Jackson, Stephen P; Adams, David J; McIntyre, Rebecca E

    2014-12-31T23:59:59.000Z

    ? pH meter (e.g. Meter Toledo MP220) 275 ? Biological safety cabinet (e.g. Fisher Scientific, #12372419) ? Reciprocating shaker (e.g. Stuart SSL2) ? Aluminum foil (e.g. Terinex) ? Single-use 0.22 m filters (e.g. Corning, #430521) ? 10 ml...

  4. Inch-Scale High Throughput Metrology of Graphene and Patterned Graphene Oxide

    E-Print Network [OSTI]

    Pleskot, Dennis

    2013-01-01T23:59:59.000Z

    Strength of Monolayer Graphene Science 2008 321, 385-388. 5.Novoselov, K. S. The rise of graphene Nature 2007 6 183-191.A. Thermal properties of graphene and nanostructured carbon

  5. Application of High Throughput Pretreatment and Co-Hydrolysis System to Thermochemical

    E-Print Network [OSTI]

    California at Riverside, University of

    Introduction Sustainable energy sources are needed to supplement petroleum use in light of limited reserves economically, a large number of factors such as feedstock quality, conversion conditions, and catalyst loadings as well as their complex interactions must be better evaluated to identify combina- tions that can

  6. High throughput low power decoder architectures for low density parity check codes

    E-Print Network [OSTI]

    Selvarathinam, Anand Manivannan

    2005-11-01T23:59:59.000Z

    . The dynamic scheme performs X soft iterations, then a parity checker cHT that computes the number of parity checks in error. Based on cHT value, the decoder decides on performing either soft iterations or a hard iteration. The advantage of the hard iteration...

  7. High-throughput indentational elasticity measurements of hydrogel extracellular matrix substrates

    E-Print Network [OSTI]

    Kumar, Sanjay

    their surroundings, including the extracellular matrix ECM and the solid-state biopolymeric scaffold to which cells

  8. ADAPTIVE MATRIX METRICS FOR ATTRIBUTE DEPENDENCE ANALYSIS IN DIFFERENTIAL HIGH-THROUGHPUT DATA

    E-Print Network [OSTI]

    Biehl, Michael

    . Corresponding author email: stricker@ipk-gatersleben.de ABSTRACT Data-driven metric adaptation is proposed descent method [7]. 2. METHOD ­ MATRIX LEARNING As input q-dimensional row vectors x R1?q are as- sumed

  9. An ultra-high throughput mutational spectrometer for human genetic diagnostics

    E-Print Network [OSTI]

    Forest, Craig Richard, 1978-

    2007-01-01T23:59:59.000Z

    Discovering the genetic causes of common diseases may require scanning for mutations in all of the genes in a million people, a significant undertaking. Such discoveries would revolutionize biotechnology, potentially ...

  10. NSF ITR Project ABSTRACTION HIERARCHY MODELING OF HIGH-THROUGHPUT SCREENING

    E-Print Network [OSTI]

    Kaber, David B.

    that are also integrated in the HTS line), this equipment has no proprietary control #12;software. The labeling/configuration" dialogs presented through an assay method programming application/interface used to control the entire AUTOMATION David B.Kaber & Steffen Junginger Overview: This document presents abstraction hierarchy (AH

  11. E-Print Network 3.0 - automated high-throughput platform Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    more rapidly screen large numbers of samples and identify the most promising biomass feedstocks for higher efficiency and lower cost bio- Summary: -Riverside (UCR), developed a...

  12. E-Print Network 3.0 - automated high-throughput screening Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    more rapidly screen large numbers of samples and identify the most promising biomass feedstocks for higher efficiency and lower cost bio- Summary: in the cost of biofuel...

  13. E-Print Network 3.0 - automated high-throughput assay Sample...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    more rapidly screen large numbers of samples and identify the most promising biomass feedstocks for higher efficiency and lower cost bio- Summary: analysts, and can require...

  14. The Development of a High-throughput Microdroplet Bioreactor Device for Microbial Studies

    E-Print Network [OSTI]

    Guzman, Adrian

    2012-10-19T23:59:59.000Z

    Current PCR Polymerase Chain Reaction MOS-FET Metal-Oxide-Semiconductor Field-Effect Transistor BSA Bovine Serum Albumin GFP Green Fluorescent Protein RFP Red Fluorescent Protein LED Light Emitting Diode PMT Photomultiplier Tubes...

  15. E-Print Network 3.0 - automated high-throughput cultivations...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and assay system... that within the next 5-10 years miniaturized and automated microfluidicsnanotech platforms that ... Source: Kjellstrm, Hedvig - School of Computer...

  16. Database Requirements for Workflow Management in a HighThroughput Genome Laboratory 1

    E-Print Network [OSTI]

    Bonner, Anthony

    @genome.wi.mit.edu 2 University of Toronto Department of Computer Science 10 King's College Rd Toronto, ON, Canada M5S constitutes an audit trail, or event history, and has much the same function as a laboratory notebook number P50 HG00098, and from the U.S. Department of Energy under contract DE­FG02­95ER62101. 1 #12

  17. LabFlow1: a Database Benchmark for HighThroughput Workflow Management ?

    E-Print Network [OSTI]

    Bonner, Anthony

    @db.toronto.edu Adel Shrufi 1 shrufi@db.toronto.edu Steve Rozen 2 steve@genome.wi.mit.edu 1 University of Toronto of workflow activity. This DBMS maintains an audit trail, or event history, that records the results of each Genome Research, grant number P50 HG00098, and from the U.S. Department of Energy under contract DE­FG02

  18. LabFlow1: a Database Benchmark for HighThroughput Workflow Management \\Lambda

    E-Print Network [OSTI]

    Bonner, Anthony

    University of Toronto Department of Computer Science 10 King's College Rd Toronto, ON, Canada M5S 1A4 2 track of workflow activity. This DBMS maintains an audit trail, or event history, that records number P50 HG00098, and from the U.S. Department of Energy under contract DE­FG02­95ER62101. #12

  19. Development of a high throughput 3D perfused liver tissue bioreactor

    E-Print Network [OSTI]

    Inman, Samuel Walker

    2006-01-01T23:59:59.000Z

    This thesis describes the development of a device designed for culturing liver tissue in a 3D perfused environment. Cells form tissue inside miniature channels of a scaffold, and the tissue is perfused with culture medium ...

  20. Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray

    E-Print Network [OSTI]

    Hook, Andrew L.

    Atomic force microscopy has been applied to an acrylate polymer microarray to achieve a full topographic characterisation. This process discovered a small number of hydro-responsive materials created from monomers with ...

  1. Inferring interactions, expression programs and regulatory networks from high throughput biological data

    E-Print Network [OSTI]

    Bar-Joseph, Ziv, 1971-

    2003-01-01T23:59:59.000Z

    (cont.) For the networks level I present an algorithm that efficiently combines complementary large-scale expression and protein-DNA binding data to discover co-regulated modules of genes. This algorithm is extended so ...

  2. ComparativeComparative InteractomicsInteractomics comparative genomics of high throughput data

    E-Print Network [OSTI]

    Utrecht, Universiteit

    of quality of expert curation (to use as source or reference) and most prolific HTP data (complex mean absence of co- complex membership #12;Estimating absence of interactions from HTP dataEstimating absence of interactions from HTP data --> yeast; what do we call an absence of interaction data> yeast

  3. High-throughput approaches to sourcing of human hepatocytes for cell-based therapies

    E-Print Network [OSTI]

    Shan, Jing (Jing Meghan)

    2014-01-01T23:59:59.000Z

    Chronic liver disease affects more than 500 million people worldwide. The only therapy shown to directly prevent mortality is organ transplantation. However, there is growing discrepancy between supply and demand of ...

  4. ORIGINAL PAPER The RABiT: high-throughput technology for assessing global DSB

    E-Print Network [OSTI]

    Brenner, David Jonathan

    . Turner · P. Sharma · J. R. Perrier · A. Bertucci · L. Smilenov · G. Johnson · M. Taveras · D. J. Brenner, and it has a H. C. Turner (&) Á P. Sharma Á J. R. Perrier Á A. Bertucci Á L. Smilenov Á G. Johnson Á M

  5. Analysis of High-Throughput Sequencing and Annotation Strategies for Phage Genomes

    E-Print Network [OSTI]

    Chisholm, Sallie (Penny)

    Background: Bacterial viruses (phages) play a critical role in shaping microbial populations as they influence both host mortality and horizontal gene transfer. As such, they have a significant impact on local and global ...

  6. Integrated microfluidic device for single-cell high throughput screening in dynamic gene expression analysis

    E-Print Network [OSTI]

    Hui, Lawrence Kwan Yeung

    2008-01-01T23:59:59.000Z

    P.J. , & Lee, L.P. , Microfluidics-based systems biology.T.M. & Quake, S.R. , Microfluidics: Fluid physics at theand applications of microfluidics in biology. Annu Rev

  7. The First Extrasolar Planet Discovered with a New Generation High Throughput Doppler Instrument

    E-Print Network [OSTI]

    Jian Ge; Julian van Eyken; Suvrath Mahadevan; Curtis DeWitt; Stephen R. Kane; Roger Cohen; Andrew Vanden Heuvel; Scott W. Fleming; Pengcheng Guo; Gregory W. Henry; Donald P. Schneider; Lawrence W. Ramsey; Robert A. Wittenmyer; Michael Endl; William D. Cochran; Eric B. Ford; Eduardo L. Martin; Garik Israelian; Jeff Valenti; David Montes

    2006-05-10T23:59:59.000Z

    We report the detection of the first extrasolar planet, ET-1 (HD 102195b), using the Exoplanet Tracker (ET), a new generation Doppler instrument. The planet orbits HD 102195, a young star with solar metallicity that may be part of the local association. The planet imparts radial velocity variability to the star with a semiamplitude of $63.4\\pm2.0$ m s$^{-1}$ and a period of 4.11 days. The planetary minimum mass ($m \\sin i$) is $0.488\\pm0.015$ $M_J$.

  8. The First Extrasolar Planet Discovered with a New Generation High Throughput Doppler Instrument

    E-Print Network [OSTI]

    Complutense de Madrid, Universidad

    ), using the Exoplanet Tracker (ET), a new generation Doppler instrument. The planet orbits HD 102195, a young star with solar metallicity that may be part of the local association. The planet imparts radial

  9. Virtual Histology of Transgenic Mouse Embryos for High-Throughput Phenotyping

    E-Print Network [OSTI]

    Capecchi, Mario R.

    . Capecchi4,5 , Charles Keller3* 1 Scientific Computing and Imaging Institute, University of Utah, Salt Lake of Pediatrics, University of Utah, Salt Lake City, Utah, United States of America, 3 Department of Cellular Genetics, University of Utah, Salt Lake City, Utah, United States of America, 5 Howard Hughes Medical

  10. High-Throughput Computational Screening of thermal conductivity, Debye temperature and Gruneisen parameter

    E-Print Network [OSTI]

    Curtarolo, Stefano

    thermal properties such as the Debye temperature and the thermal conductivity of materials. We demonstrate studied for the past few decades6 . Low thermal conductivity mate- rials constitute the basis of a new and predict the thermal conductivity of differ- ent materials8,9,11­16 . Such evaluation of the higher

  11. Encoded hydrogel microparticles for high-throughput molecular diagnostics and personalized medicine

    E-Print Network [OSTI]

    Chapin, Stephen Clifford

    2012-01-01T23:59:59.000Z

    The ability to accurately detect and quantify biological molecules in complex mixtures is crucial in basic research as well as in clinical settings. Advancements in genetic analysis, molecular diagnostics, and patient-tailored ...

  12. High-throughput Microfluidics and Ultrafast Optics for in Vivo Compound/Genetic Discoveries

    E-Print Network [OSTI]

    Rohde, Christopher Benjamin

    Therapeutic treatment of spinal cord injuries, brain trauma, stroke, and neurodegenerative diseases will greatly benefit from the discovery of compounds that enhance neuronal regeneration following injury. We previously ...

  13. High-throughput microfluidic living cell arrays for spatiotemporal gene expression profiling

    E-Print Network [OSTI]

    King, Kevin R. (Kevin Robert), 1976-

    2008-01-01T23:59:59.000Z

    The cellular microenvironment is remarkably complex. In the small space near each cell, growth factors are liberated from extracellular matrix, cytokines are secreted from neighboring cells, and hormones arrive from distant ...

  14. Use of high-throughput mass spectrometry to elucidate host pathogen

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear SecurityTensile Strain Switched Ferromagnetism inS-4500II Field Emission SEM

  15. High-throughput Characterization of Porous Materials Using Graphics Processing Units

    E-Print Network [OSTI]

    Kim, Jihan

    2013-01-01T23:59:59.000Z

    A.E. ; Purcell, T. Computer Graphics Forum 2007, 26(1), 80-of Porous Materials Using Graphics Processing Units Jihanof Porous Materials Using Graphics Processing Units Jihan

  16. High Throughput Web Inspection System using Time-stretch Real-time Imaging

    E-Print Network [OSTI]

    Kim, Chanju

    2013-01-01T23:59:59.000Z

    successfully report a dark-field web inspection system withsample substrate for our dark-field web inspection systemweb inspection system exploiting time- stretch and utilizing the merits coming from dark-

  17. Pathway-centric approaches to the analysis of high-throughput genomics data.

    E-Print Network [OSTI]

    Hnzelmann, Sonja, 1981-

    2012-01-01T23:59:59.000Z

    ??In the last decade, molecular biology has expanded from a reductionist view to a systems-wide view that tries to unravel the complex interactions of cellular (more)

  18. Agenda from the U.S. Department of Energy's High Throughput Screening of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartment of EnergyAdministrative2|DepartmentDOEHydrogen Storage Materials

  19. High-Throughput/Combinatorial Techniques in Hydrogen Storage Materials R&D

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:Year in3.pdfEnergy Health and Productivity QuestionnaireSingle Emitter |VolumeEnergyR|

  20. Improved Algae-based Biorefining and High-throughput Screening of Algal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmospheric Optical Depth7-1D: Vegetation ProposedUsingFun withconfinementEtching.348 270 300 219 255 135 1982-2015 East

  1. High-Throughput/Combinatorial Techniques in Hydrogen Storage Materials R&D

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-UpHeatMulti-Dimensional Subject:Ground HawaiiWaste Heat Recovery: Successa(presentation)

  2. Biochemical & Thermochemical High Throughput Characterization of Feedstocks Presentation for BETO 2015 Project Peer Review

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartmentTie Ltd: ScopeDepartment1, 2011 DRAFTofBio-Oil Deployment in the Home 20

  3. Biochemical & Thermochemical High Throughput Characterization of Feedstocks for BETO 2015 Project Peer Review

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartmentTie Ltd: ScopeDepartment1, 2011 DRAFTofBio-Oil Deployment in the Home 20

  4. Attendees list from the U.S. Department of Energy's High Throughput

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:YearRound-Up fromDepartmentTie Ltd: Scope Change #1Impacts5)Integration - Strategy andNameScreening

  5. Quantum-Dot-Based Electrochemical Immunoassay for High-Throughput Screening

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr MayAtmosphericNuclear Security Administration the1 -the Mid-Infrared at 278, 298, and 323 K. |Quantum Field Theory &formats forof

  6. An LC-IMS-MS Platform Providing Increased Dynamic Range for High-Throughput

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to someone by E-mail ShareRed CrossAn Iridate with Fermi Arcs AnProteomic

  7. High-Throughput Screening for Functional Adenosine to Inosine RNA Editing Systems

    E-Print Network [OSTI]

    Beal, Peter A.

    and Peter A. Beal* Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah sequence changes to maintain an open reading frame and create a stop codon *Corresponding author, beal

  8. Development Tools at NERSC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsruc DocumentationP-Series to UserProduct: CrudeOfficeNERSC Helps Develop Next-GenEMSL ResearchTools

  9. ARM - Data Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformationbudapest Comments? We would love toContact Information Related LinksDailyJulygovData Tools Data

  10. Flow-Through Microfluidic Device for High-Efficiency Transfection of Mammalian Cells through Combined Microelectroporation and Sonoporation

    E-Print Network [OSTI]

    Longsine, Whitney Leigh

    2012-07-16T23:59:59.000Z

    In this study we are presenting a proof-of-concept microfluidic device that simultaneously applies the conditions required for microelectroporation and micro-sonoporation in a flow-through fashion that allows for high throughput, high efficiency...

  11. 5, 12291261, 2012 diagnostic tool

    E-Print Network [OSTI]

    Gettelman, Andrew

    GMDD 5, 1229­1261, 2012 Community diagnostic tool A. Gettelman et al. Title Page Abstract to the corresponding final paper in GMD if available. A community diagnostic tool for Chemistry Climate Model Community diagnostic tool A. Gettelman et al. Title Page Abstract Introduction Conclusions References Tables

  12. NISTIR 7100 PDA Forensic Tools

    E-Print Network [OSTI]

    NISTIR 7100 PDA Forensic Tools: AnOverviewandAnalysis RickAyers WayneJansen #12;ii NISTIR 7100 C O M P U T E R S E C U R I T Y PDA Forensic Tools: An Overview and Analysis Rick Ayers Wayne Jansen incident, forensic examiners require tools that allow the proper retrieval and speedy examination

  13. Butt Joint Tool Commissioning

    SciTech Connect (OSTI)

    Martovetsky, N N

    2007-12-06T23:59:59.000Z

    ITER Central Solenoid uses butt joints for connecting the pancakes in the CS module. The principles of the butt joining of the CICC were developed by the JAPT during CSMC project. The difference between the CSMC butt joint and the CS butt joint is that the CS butt joint is an in-line joint, while the CSMC is a double joint through a hairpin jumper. The CS butt joint has to carry the hoop load. The straight length of the joint is only 320 mm, and the vacuum chamber around the joint has to have a split in the clamp shell. These requirements are challenging. Fig.1 presents a CSMC joint, and Fig.2 shows a CS butt joint. The butt joint procedure was verified and demonstrated. The tool is capable of achieving all specified parameters. The vacuum in the end was a little higher than the target, which is not critical and readily correctable. We consider, tentatively that the procedure is established. Unexpectedly, we discover significant temperature nonuniformity in the joint cross section, which is not formally a violation of the specs, but is a point of concern. All testing parameters are recorded for QA purposes. We plan to modify the butt joining tool to improve its convenience of operation and provide all features necessary for production of butt joints by qualified personnel.

  14. BEAM EMITTANCE MEASUREMENT TOOL FOR CEBAF OPERATIONS

    SciTech Connect (OSTI)

    Chevtsov, Pavel; Tiefenback, Michael

    2008-10-01T23:59:59.000Z

    A new software tool was created at Jefferson Lab to measure the emittance of the CEBAF electron beams. The tool consists of device control and data analysis applications. The device control application handles the work of wire scanners and writes their measurement results as well as the information about accelerator settings during these measurements into wire scanner data files. The data analysis application reads these files and calculates the beam emittance on the basis of a wire scanner data processing model. Both applications are computer platform independent but are mostly used on LINUX PCs recently installed in the accelerator control room. The new tool significantly simplifies beam emittance measurement procedures for accelerator operations and contributes to a very high availability of the CEBAF machine for the nuclear physics program at Jefferson Lab.

  15. Downhole tool adapted for telemetry

    DOE Patents [OSTI]

    Hall, David R. (Provo, UT); Fox, Joe (Provo, UT)

    2010-12-14T23:59:59.000Z

    A cycleable downhole tool such as a Jar, a hydraulic hammer, and a shock absorber adapted for telemetry. This invention applies to other tools where the active components of the tool are displaced when the tool is rotationally or translationally cycled. The invention consists of inductive or contact transmission rings that are connected by an extensible conductor. The extensible conductor permits the transmission of the signal before, after, and during the cycling of the tool. The signal may be continuous or intermittent during cycling. The invention also applies to downhole tools that do not cycle, but in operation are under such stress that an extensible conductor is beneficial. The extensible conductor may also consist of an extensible portion and a fixed portion. The extensible conductor also features clamps that maintain the conductor under stresses greater than that seen by the tool, and seals that are capable of protecting against downhole pressure and contamination.

  16. Development of a HT seismic downhole tool.

    SciTech Connect (OSTI)

    Maldonado, Frank P.; Greving, Jeffrey J.; Henfling, Joseph Anthony; Chavira, David J.; Uhl, James Eugene; Polsky, Yarom

    2009-06-01T23:59:59.000Z

    Enhanced Geothermal Systems (EGS) require the stimulation of the drilled well, likely through hydraulic fracturing. Whether fracturing of the rock occurs by shear destabilization of natural fractures or by extensional failure of weaker zones, control of the fracture process will be required to create the flow paths necessary for effective heat mining. As such, microseismic monitoring provides one method for real-time mapping of the fractures created during the hydraulic fracturing process. This monitoring is necessary to help assess stimulation effectiveness and provide the information necessary to properly create the reservoir. In addition, reservoir monitoring of the microseismic activity can provide information on reservoir performance and evolution over time. To our knowledge, no seismic tool exists that will operate above 125 C for the long monitoring durations that may be necessary. Replacing failed tools is costly and introduces potential errors such as depth variance, etc. Sandia has designed a high temperature seismic tool for long-term deployment in geothermal applications. It is capable of detecting microseismic events and operating continuously at temperatures up to 240 C. This project includes the design and fabrication of two High Temperature (HT) seismic tools that will have the capability to operate in both temporary and long-term monitoring modes. To ensure the developed tool meets industry requirements for high sampling rates (>2ksps) and high resolution (24-bit Analog-to-Digital Converter) two electronic designs will be implemented. One electronic design will utilize newly developed 200 C electronic components. The other design will use qualified Silicon-on-Insulator (SOI) devices and will have a continuous operating temperature of 240 C.

  17. Global Solar Opportunity Tool: A Tool for Policy Makers and Energy...

    Open Energy Info (EERE)

    and Energy Analysts Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Global Solar Opportunity Tool: A Tool for Policy Makers and Energy Analysts Focus Area: Solar...

  18. Electronic authoring tools

    SciTech Connect (OSTI)

    Hurford, J.M.

    1987-01-01T23:59:59.000Z

    More than a decade ago, word processing software revolutionized the way documents were prepared, and productivity was increased. But the editing and formatting capabilities of most word processors did very little to prevent errors in spelling, typing, grammar, diction, style, or organization from slipping through to the final documents. In the past few years, the number of software tools that aid the author has increased substantially. They now vary in scope from simple spelling checkers to sophisticated diction analyzers and idea processors. Moreover, writing-aid-software described in this report is now available for many types of computing systems, including personal computers, scientific workstations, and mainframes. The various pieces of software can be used in interactive or non-interactive (batch) modes.

  19. One of John Dempsey Hospital's new quality improvement tools

    E-Print Network [OSTI]

    Oliver, Douglas L.

    One of John Dempsey Hospital's new quality improvement tools borrows lessons learned from the nuclear power industry, manufac turing and aviation. "Safety is a science. Reliability is a science, is a former Navy pilot. "We're learning specific tools based on high reliability tech niques to improve

  20. A novel polymeric microelectrode array for highly parallel, long-term neuronal culture and stimulation

    E-Print Network [OSTI]

    Talei Franzesi, Giovanni

    2008-01-01T23:59:59.000Z

    Cell-based high-throughput screening is emerging as a disruptive technology in drug discovery; however, massively parallel electrical assaying of neurons and cardiomyocites has until now been prohibitively expensive. To ...

  1. Increasing throughput of multiplexed electrical bus in pipe-lined architecture

    DOE Patents [OSTI]

    Asaad, Sameh; Brezzo, Bernard V; Kapur, Mohit

    2014-05-27T23:59:59.000Z

    Techniques are disclosed for increasing the throughput of a multiplexed electrical bus by exploiting available pipeline stages of a computer or other system. For example, a method for increasing a throughput of an electrical bus that connects at least two devices in a system comprises introducing at least one signal hold stage in a signal-receiving one of the two devices, such that a maximum frequency at which the two devices are operated is not limited by a number of cycles of an operating frequency of the electrical bus needed for a signal to propagate from a signal-transmitting one of the two devices to the signal-receiving one of the two devices. Preferably, the signal hold stage introduced in the signal-receiving one of the two devices is a pipeline stage re-allocated from the signal-transmitting one of the two devices.

  2. A simple packet retransmission strategy for throughput and delay enhancement on power line communication channels

    SciTech Connect (OSTI)

    Onunga, J.O. (Kenya Posts and Telecommunications Corp., Nairobi (Kenya)); Donaldson, R.W. (Univ. of British Columbia, Vancouver (Canada). Dept. of Electrical Engineering)

    1993-07-01T23:59:59.000Z

    A new, simple, and effective communication protocol is developed and evaluated for use on power line distribution networks. The protocol involves retransmission of unacknowledged packets, which are sent in either single or multiple (N) copies in accordance with estimates of communication link quality. Multiple packet copies can be code combined at the receiver, using majority voting on each bit position, to reduce packet error rates. Adaptive link quality estimates are based on the receipt or absence of positive acknowledgements. Information throughput efficiency is calculated and N optimized in terms of system variables. Performance benefits of code combining are clearly demonstrated. The algorithm was implemented and tested using a five-station intrabuilding power line communications network operating at 1.2, 2.4, 4.8 and 9.6 kbit/s data rate. Substantial throughput and delay improvement occurred on poor quality links, without degrading performance on good links.

  3. Steam System Tool Suite Introduction Guide

    E-Print Network [OSTI]

    Oak Ridge National Laboratory

    Steam System Tool Suite Introduction Guide Alternate Text Narratives and Graphic.............................................................................................................................6 Modules Steam System Scoping Tool (SSST)........................................................................................8 Steam System Assessment Tool (SSAT

  4. Virtual Crosswalk Analysis Tool (VCAT)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    standard business representations show only the intended relationships and miss the rest. Social networking and data mining tools may show intended relationships and ignore the...

  5. Tool Wear in Friction Drilling

    SciTech Connect (OSTI)

    Miller, Scott F [ORNL; Blau, Peter Julian [ORNL; Shih, Albert J. [University of Michigan

    2007-01-01T23:59:59.000Z

    This study investigated the wear of carbide tools used in friction drilling, a nontraditional hole-making process. In friction drilling, a rotating conical tool uses the heat generated by friction to soften and penetrate a thin workpiece and create a bushing without generating chips. The wear of a hard tungsten carbide tool used for friction drilling a low carbon steel workpiece has been investigated. Tool wear characteristics were studied by measuring its weight change, detecting changes in its shape with a coordinate measuring machine, and making observations of wear damage using scanning electron microscopy. Energy dispersive spectroscopy was applied to analyze the change in chemical composition of the tool surface due to drilling. In addition, the thrust force and torque during drilling and the hole size were measured periodically to monitor the effects of tool wear. Results indicate that the carbide tool is durable, showing minimal tool wear after drilling 11000 holes, but observations also indicate progressively severe abrasive grooving on the tool tip.

  6. Supporting integrated design through interlinked tools: The Labs21 toolkit

    SciTech Connect (OSTI)

    Mathew, Paul; Bell, Geoffrey; Carlisle, Nancy; Sartor, Dale; van Geet, Otto; Lintner, William; Wirdzek, Phil

    2003-09-15T23:59:59.000Z

    The sustainable design of complex building types such as laboratories and hospitals can be particularly challenging, given their inherent complexity of systems, health and safety requirements, long-term flexibility and adaptability needs, energy use intensity, and environmental impacts. Tools such as design guides, energy benchmarking, and LEED rating systems are especially helpful to support sustainable design in such buildings. Furthermore, designers need guidance on how to effectively and appropriately use each tool within the context of an integrated design process involving multiple actors with various objectives. Toward this end, the Laboratories for the 21st Century (Labs21) program has developed an interlinked set of tools -- the Labs21 Toolkit -- to support an integrated design process for sustainable laboratories. Labs21 is a voluntary partnership program sponsored by the U.S. Environmental Protection Agency (EPA) and U.S. Department of Energy (DOE) to improve the environment al performance of U.S. laboratories. In this paper, we present the Labs21 Toolkit, and illustrate how these tools can be used to support sustainable design within an integrated design process. The tool kit includes core information tools, as well as process-related tools, as indicated below: Core information tools: -A Design Guide, which is a compendium of publications on energy efficiency in laboratories -Case Studies that showcase high-performance design features and applications. -Best Practice Guides that highlight industry-leading sustainable design strategies. -A web-based Benchmarking Tool to benchmark laboratory energy performance.Process tools: -A Design Intent Tool, which can be used to used to plan, document, and verify that a facility's design intent is being met at each stage of the design process. The Environmental Performance Criteria (EPC), a rating system specifically designed for laboratory facilities that builds on the LEED(TM) system. -A web-based Process Manual, that provides a ''portal'' to the tools and a step-by-step process for using these tools during each stage of the design process.

  7. Prototyping Regional Discrimination Tools with Matseis

    SciTech Connect (OSTI)

    Chael, Eric; Harris, Mark; Young, Chris; Mayeda, Kevin; Walter, William; Taylor, Steve; Velasco, Aaron

    1999-08-03T23:59:59.000Z

    To facilitate the development testing and comparison of regional seismic discriminants, we have implemented some of the most promising techniques in Matseis, a-Matlab-based seismic processing toolkit. The existing Matseis package provides graphical tools for analyzing seismic data from a network of stations. It can access data via a CSS 3.0 database, or from static files in a format defined by the user. Waveforms are displayed in a record-section format, with overlays for IASPE191 travel-time curves. The user can pick arrivals and locate events, then show the results on a map. Tools are available for spectral and polarization measurements, as well as beam forming and f-k analysis with array data. Additionally, one has full access to the Matlab environment and any functions available there, as well as to portions of the U.S. Department of Energy Knowledge Base. Recently, we have added some new tools to Matseis for calculating regional discrimination measurements. The first of these performs Lg coda analysis as developed by Mayeda and coworkers at Lawrence Livermore National Laboratory (LLNL). Lg coda magnitudes are calculated from the amplitudes of the coda envelopes in narrow frequency bands. Ratios of these amplitudes between high- and low-frequency bands provide a spectral-ratio discriminant for regional events. The second tool we have implemented measures P/Lg phase ratios, using the MDAC technique of Taylor (Los Alamos National Laboratory) and Walter (LLNL). P and Lg amplitudes are obtained at select frequencies, then corrected for source magnitude and propagation path. Finally, we added a tool for analyzing long-period Rayleigh and Love arrivals, useful for moment:magnitude and LQ:LR discrimination. Because all these tools have been written as Matlab functions, they can be easily modified to experiment with different processing details. The performance of the discriminants can be evaluated using any event available in the database.

  8. Information Technology Tools for Multifamily Building Programs...

    Energy Savers [EERE]

    Information Technology Tools for Multifamily Building Programs Information Technology Tools for Multifamily Building Programs Better Buildings Neighborhood Program Multifamily ...

  9. Automated energy monitoring of machine tools

    E-Print Network [OSTI]

    Vijayaraghavan, Athulan; Dornfeld, David

    2010-01-01T23:59:59.000Z

    in manufacturing the tooling for many consumer products,process parameters, tooling, and cutting ?uid based on

  10. Survey of Existing Tools for Formal Verification.

    SciTech Connect (OSTI)

    Punnoose, Ratish J.; Armstrong, Robert C.; Wong, Matthew H.; Jackson, Mayo

    2014-12-01T23:59:59.000Z

    Formal methods have come into wide use because of their effectiveness in verifying %22safety and security%22 requirements of digital systems; a set of requirements for which testing is mostly ineffective. Formal methods are routinely used in the design and verification of high-consequence digital systems in industry. This report outlines our work in assessing the capabilities of commercial and open source formal tools and the ways in which they can be leveraged in digital design workflows.

  11. Computational Tools for Supersymmetry Calculations

    E-Print Network [OSTI]

    Howard Baer

    2009-12-16T23:59:59.000Z

    I present a brief overview of a variety of computational tools for supersymmetry calculations, including: spectrum generators, cross section and branching fraction calculators, low energy constraints, general purpose event generators, matrix element event generators, SUSY dark matter codes, parameter extraction codes and Les Houches interface tools.

  12. Tools for charged Higgs bosons

    E-Print Network [OSTI]

    Oscar Stl

    2010-12-13T23:59:59.000Z

    We review the status of publicly available software tools applicable to charged Higgs physics. A selection of codes are highlighted in more detail, focusing on new developments that have taken place since the previous charged Higgs workshop in 2008. We conclude that phenomenologists now have the tools ready to face the LHC data. A new webpage collecting charged Higgs resources is presented.

  13. Data Mining Tools Irfan Altas

    E-Print Network [OSTI]

    Turlach, Berwin A.

    Data Mining Tools Irfan Altas School of Information Studies, Charles Sturt University Wagga Wagga discuss several scalable and parallel discovery and predictive data mining tools. They successfully address many of the computational challenges associated with the analy sis of data sets with millions

  14. Vehicle assisted harpoon breaching tool

    DOE Patents [OSTI]

    Pacheco, James E. (Albuquerque, NM); Highland, Steven E. (Albuquerque, NM)

    2011-02-15T23:59:59.000Z

    A harpoon breaching tool that allows security officers, SWAT teams, police, firemen, soldiers, or others to forcibly breach metal doors or walls very quickly (in a few seconds), without explosives. The harpoon breaching tool can be mounted to a vehicle's standard receiver hitch.

  15. Science with Virtual Observatory Tools

    E-Print Network [OSTI]

    P. Padovani

    2004-11-12T23:59:59.000Z

    The Virtual Observatory is now mature enough to produce cutting-edge science results. The exploitation of astronomical data beyond classical identification limits with interoperable tools for statistical identification of sources has become a reality. I present the discovery of 68 optically faint, obscured (i.e., type 2) active galactic nuclei (AGN) candidates in the two GOODS fields using the Astrophysical Virtual Observatory (AVO) prototype. Thirty-one of these sources have high estimated X-ray powers (>10^44 erg/s) and therefore qualify as optically obscured quasars, the so-called QSO 2. The number of these objects in the GOODS fields is now 40, an improvement of a factor > 4 when compared to the only 9 such sources previously known. By going ~ 3 magnitudes fainter than previously known type 2 AGN in the GOODS fields the AVO is sampling a region of redshift -- power space much harder to reach with classical methods. I also discuss the AVO move to our next phase, the EURO-VO, and our short-term plans to continue doing science with the Virtual Observatory.

  16. Summary Xylem vulnerability to cavitation is a promising criterion for identifying trees with high drought tolerance, but

    E-Print Network [OSTI]

    Mencuccini, Maurizio

    Summary Xylem vulnerability to cavitation is a promising criterion for identifying trees with high drought tolerance, but traditional techniques for measuring cavitation resistance are unsuitablefor throughput screening of cavitation resistance in five poplar (Populus spp.) andfour willow (Salix spp

  17. Tools for dynamic model development

    E-Print Network [OSTI]

    Schaber, Spencer Daniel

    2014-01-01T23:59:59.000Z

    For this thesis, several tools for dynamic model development were developed and analyzed. Dynamic models can be used to simulate and optimize the behavior of a great number of natural and engineered systems, from the ...

  18. Nonstandard Tools for Nonsmooth Analysis

    E-Print Network [OSTI]

    S. S. Kutateladze

    2012-06-11T23:59:59.000Z

    This is an overview of the basic tools of nonsmooth analysis which are grounded on nonstandard models of set theory. By way of illustration we give a criterion for an infinitesimally optimal path of a general discrete dynamic system.

  19. Management System Verification (MSV) Tool

    Broader source: Energy.gov [DOE]

    The MSV process developed by ACC is a tool (not a requirement) that DOE sites may consider to help determine whether their ES&H program is truly integrated into all work at all levels by all employees.

  20. Seal for fluid forming tools

    DOE Patents [OSTI]

    Golovashchenko, Sergey Fedorovich (Beverly Hills, MI); Bonnen, John Joseph Francis (Milford, MI)

    2012-03-20T23:59:59.000Z

    An electro-hydraulic forming tool for forming a sheet metal blank in a one-sided die has first and second rigid rings that engage opposite sides of a sheet metal blank. The rigid rings are contained within slots on a die portion and a hydraulic force applicator portion of the forming tool. The seals are either resiliently biased by an elastomeric member or inherently resiliently biased into contact with the blank.

  1. Eastern Energy Zones Mapping Tool

    Broader source: Energy.gov [DOE]

    The Eastern Interconnection States Planning Council (EISPC) has released the Energy Zones (EZ) Mapping Tool, a free, web-based interactive tool that will help states and other stakeholders in the Eastern Interconnection identify geographic areas suitable for the development of clean energy resources (natural gas, sequestration or utilitization locations for C02 from coal, nuclear, and renewable) which can potentially provide significant amounts of new electric power generation.

  2. Full-scale tests help improve reliability of DST tools

    SciTech Connect (OSTI)

    Ringgenberg, P. [Halliburton Energy Services, Dallas, TX (United States); Self, J.C. [Statoil, Stavanger (Norway)

    1996-08-05T23:59:59.000Z

    A joint-industry project set up procedures and full scale tests to determine the reliability and integrity of drill stem test (DST) tools for use in difficult high pressure, high temperature wells. These DST tool tests helped determine changes needed to address reliability in high pressure, high temperature (HPHT) conditions and has demonstrated that DST tools could maintain integrity in this type of environment. Eleven major operators and service/testing companies in the Norway/U.K. area undertook a joint industry study to address these problems and to determine methods to increase the reliability of DST operations in HPHT well testing. Emphasis was placed on the selection of the downhole equipment used for the HPHT drill stem tests and design of the full scale testing of the North-Sea-area field tools in use. Additionally, an investigation was to be made to establish methods that could be used to verify and increase equipment reliability. The project also included design parameters for contingency conditions that were not normally present during equipment operations but could exist in emergency situations. Eleven tools, including tester valves, multiple-cycle circulating valves, bypass valves, and safety/circulating valves, from different service company/suppliers were rigorously tested. The paper describes the project, the tools tested, test methods, and results.

  3. Design tools for passive solar applications

    SciTech Connect (OSTI)

    Balcomb, J.D.

    1986-04-01T23:59:59.000Z

    Examples of passive solar design tools are given, categorized as either evaluation tools or guidance tools. A trend toward microcomputer-based tools is noted; however, these are usually developed for use by engineers rather than architects. The need for more instructive tools targeted specifically to designers is emphasized.

  4. Computational Tools for Accelerating Carbon Capture Process Development

    SciTech Connect (OSTI)

    Miller, David

    2013-01-01T23:59:59.000Z

    The goals of the work reported are: to develop new computational tools and models to enable industry to more rapidly develop and deploy new advanced energy technologies; to demonstrate the capabilities of the CCSI Toolset on non-proprietary case studies; and to deploy the CCSI Toolset to industry. Challenges of simulating carbon capture (and other) processes include: dealing with multiple scales (particle, device, and whole process scales); integration across scales; verification, validation, and uncertainty; and decision support. The tools cover: risk analysis and decision making; validated, high-fidelity CFD; high-resolution filtered sub-models; process design and optimization tools; advanced process control and dynamics; process models; basic data sub-models; and cross-cutting integration tools.

  5. E-Print Network 3.0 - amazingly versatile tool Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Department of Physics, High Energy Physics Group Collection: Physics 96 Creating Sustainability and Value in Uncertain Times Summary: with complicated tools, some of them still...

  6. NREL Developing a Numerical Simulation Tool to Study Hydrokinetic Energy Conversion Devices and Arrays (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2012-02-01T23:59:59.000Z

    New code will help accelerate design improvements by providing a high-fidelity simulation tool to study power performance, structural loading, and the interactions between devices in arrays.

  7. Design Tool for Cryogenic Thermal Insulation Systems

    SciTech Connect (OSTI)

    Demko, Jonathan A [ORNL] [ORNL; Fesmire, J. E. [NASA Kennedy Space Center, Kennedy Space Center, Florida] [NASA Kennedy Space Center, Kennedy Space Center, Florida; Augustynowicz, S. D. [Sierra Lobo Inc., Kennedy Space Center, Florida] [Sierra Lobo Inc., Kennedy Space Center, Florida

    2008-01-01T23:59:59.000Z

    Thermal isolation of low-temperature systems from ambient environments is a constant issue faced by practitioners of cryogenics. For energy-efficient systems and processes to be realized, thermal insulation must be considered as an integrated system, not merely an add-on element. A design tool to determine the performance of insulation systems for comparative trade-off studies of different available material options was developed. The approach is to apply thermal analysis to standard shapes (plane walls, cylinders, spheres) that are relatively simple to characterize with a one-dimensional analytical or numerical model. The user describes the system hot and cold boundary geometry and the operating environment. Basic outputs such as heat load and temperature profiles are determined. The user can select from a built-in insulation material database or input user defined materials. Existing information has been combined with the new experimental thermal conductivity data produced by the Cryogenics Test Laboratory for cryogenic and vacuum environments, including high vacuum, soft vacuum, and no vacuum. Materials in the design tool include multilayer insulation, aerogel blankets, aerogel bulk-fill, foams, powders, composites, and other insulation system constructions. A comparison of the design tool to a specific composite thermal insulation system is given.

  8. NREL: Technology Deployment - Models and Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for improving this tool? Please send us an email with your thoughts. The Community Solar Scenario Tool (CSST) provides a "first cut" analysis of different community or...

  9. NREL: Systems Engineering - Models and Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and Tools The NREL Systems Engineering Initiative develops, integrates, and analyzes wind energy system models. NREL has developed an overall integrated system analysis tool...

  10. Clean Cities & Transportation Tools | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    & Transportation Tools Clean Cities & Transportation Tools U.S. Department of Energy (DOE) Technical Assistance Project (TAP) for state and local officials Webinar presentation on...

  11. VISTA - computational tools for comparative genomics

    E-Print Network [OSTI]

    Frazer, Kelly A.; Pachter, Lior; Poliakov, Alexander; Rubin, Edward M.; Dubchak, Inna

    2004-01-01T23:59:59.000Z

    tools for comparative genomics Kelly A. Frazer 1 , LiorBerkeley, CA, 94720 Genomics Division, Lawrence Berkeleymultiple comparative genomics tools and provides users with

  12. Tools for Living and Tools for Learning Stefan Carmien and Gerhard Fischer

    E-Print Network [OSTI]

    Fischer, Gerhard

    Tools for Living and Tools for Learning Stefan Carmien and Gerhard Fischer University of Colorado as tools, particularly computational artifacts. We introduce the notions of tools for living and tools for the design of artifacts. The tools concept is then studied in the context of the Memory Aiding Prompting

  13. Combination drilling and skiving tool

    DOE Patents [OSTI]

    Stone, William J. (Kansas City, MO)

    1989-01-01T23:59:59.000Z

    A combination drilling and skiving tool including a longitudinally extending hollow skiving sleeve slidably and concentrically mounted on a right-handed twist drill. Dogs or pawls provided on the internal periphery of the skiving sleeve engage with the helical grooves of the drill. During a clockwise rotation of the tool, the drill moves downwardly and the sleeve translates upwardly, so that the drill performs a drilling operation on a workpiece. On the other hand, the drill moves upwardly and the sleeve translates downwardly, when the tool is rotated in a counter-clockwise direction, and the sleeve performs a skiving operation. The drilling and skiving operations are separate, independent and exclusive of each other.

  14. A Review of High Occupancy Vehicle (HOV) Lane Performance and...

    Open Energy Info (EERE)

    Occupancy Vehicle (HOV) Lane Performance and Policy Options in the United States: Final Report Jump to: navigation, search Tool Summary LAUNCH TOOL Name: A Review of High Occupancy...

  15. U.S. Department of Energy Categorical Exclusion Determination...

    Broader source: Energy.gov (indexed) [DOE]

    2) LBNL & Wildcat Disc. Tech - High Throughput Tools to Screen New Metal Organic Framework Materials Location: California Proposed Action or Project Description: American Recovcl)'...

  16. Analytic tools for information warfare

    SciTech Connect (OSTI)

    Vandewart, R.L.; Craft, R.L.

    1996-05-01T23:59:59.000Z

    Information warfare and system surety (tradeoffs between system functionality, security, safety, reliability, cost, usability) have many mechanisms in common. Sandia`s experience has shown that an information system must be assessed from a {ital system} perspective in order to adequately identify and mitigate the risks present in the system. While some tools are available to help in this work, the process is largely manual. An integrated, extensible set of assessment tools would help the surety analyst. This paper describes one approach to surety assessment used at Sandia, identifies the difficulties in this process, and proposes a set of features desirable in an automated environment to support this process.

  17. Tools for measuring surface cleanliness

    DOE Patents [OSTI]

    Schroder, Mark Stewart (Hendersonville, NC); Woodmansee, Donald Ernest (Simpsonville, SC); Beadie, Douglas Frank (Greenville, SC)

    2002-01-01T23:59:59.000Z

    A procedure and tools for quantifying surface cleanliness are described. Cleanliness of a target surface is quantified by wiping a prescribed area of the surface with a flexible, bright white cloth swatch, preferably mounted on a special tool. The cloth picks up a substantial amount of any particulate surface contamination. The amount of contamination is determined by measuring the reflectivity loss of the cloth before and after wiping on the contaminated system and comparing that loss to a previous calibration with similar contamination. In the alternative, a visual comparison of the contaminated cloth to a contamination key provides an indication of the surface cleanliness.

  18. Using Performance Tools to Support Experiments in HPC Resilience

    SciTech Connect (OSTI)

    Naughton, III, Thomas J [ORNL; Boehm, Swen [ORNL] [ORNL; Engelmann, Christian [ORNL] [ORNL; Vallee, Geoffroy R [ORNL] [ORNL

    2014-01-01T23:59:59.000Z

    The high performance computing (HPC) community is working to address fault tolerance and resilience concerns for current and future large scale computing platforms. This is driving enhancements in the programming environ- ments, specifically research on enhancing message passing libraries to support fault tolerant computing capabilities. The community has also recognized that tools for resilience experimentation are greatly lacking. However, we argue that there are several parallels between performance tools and resilience tools . As such, we believe the rich set of HPC performance-focused tools can be extended (repurposed) to benefit the resilience community. In this paper, we describe the initial motivation to leverage standard HPC per- formance analysis techniques to aid in developing diagnostic tools to assist fault tolerance experiments for HPC applications. These diagnosis procedures help to provide context for the system when the errors (failures) occurred. We describe our initial work in leveraging an MPI performance trace tool to assist in provid- ing global context during fault injection experiments. Such tools will assist the HPC resilience community as they extend existing and new application codes to support fault tolerances.

  19. Utility Maximization for Resolving Throughput/Reliability Trade-offs in an Unreliable Network with Multipath Routing

    E-Print Network [OSTI]

    Utility Maximization for Resolving Throughput/Reliability Trade-offs in an Unreliable Network can be characterized by some utility function, the goal of balancing competing requirements for each user as well as across different users is to maximize the aggregate utility. The framework assumes

  20. VCAT: Visual Crosswalk Analysis Tool

    SciTech Connect (OSTI)

    Cleland, Timothy J. [Los Alamos National Laboratory; Forslund, David W. [Los Alamos National Laboratory; Cleland, Catherine A. [Los Alamos National Laboratory

    2012-08-31T23:59:59.000Z

    VCAT is a knowledge modeling and analysis tool. It was synthesized from ideas in functional analysis, business process modeling, and complex network science. VCAT discovers synergies by analyzing natural language descriptions. Specifically, it creates visual analytic perspectives that capture intended organization structures, then overlays the serendipitous relationships that point to potential synergies within an organization or across multiple organizations.

  1. From Metaphor to Analytic Tool

    E-Print Network [OSTI]

    Process Tracing From Metaphor to Analytic Tool Edited by ANDREW BENNETT and JEFFREY T. CHECKEL process tracing." Andrew Bennett is Professor of Government at Georgetown Uni versity. He is also: © VvoeVale/iStock.com series cover design: sue watson "Bennett and Checkel have assembled an im- pressive

  2. DREAM tool increases space weather predictions

    E-Print Network [OSTI]

    - 1 - DREAM tool increases space weather predictions April 13, 2012 Predicting space weather improved by new DREAM modeling tool Earth's radiation belts can now be studied with a new modeling tool DREAM comes into play. Radiation belt structure and dynamics revealed DREAM is a modeling tool

  3. Search Tool for Leveraged Procurement Agreements

    E-Print Network [OSTI]

    Search Tool for Leveraged Procurement Agreements (LPA) Illustrated User Manual #12;2 Search Tool://www.bidsync.com #12;3 Search Tool for Leveraged Procurement Agreements (LPA) Rev. 5/5/09 Introduction Bid: Select Search Contracts/Leveraged Procurement Agreements (LPA's). #12;4 Search Tool for Leveraged

  4. Energy Performance Certification of Buildings: A Policy Tool...

    Open Energy Info (EERE)

    Buildings: A Policy Tool to Improve Energy Efficiency Jump to: navigation, search Tool Summary LAUNCH TOOL Name: Energy Performance Certification of Buildings: A Policy Tool to...

  5. High-Temperature-High-Volume Lifting for Enhanced Geothermal...

    Broader source: Energy.gov (indexed) [DOE]

    Norman Turnquist GE Global Research High Temperature Tools and Sensors, Down-hole Pumps and Drilling May 19, 2010 This presentation does not contain any proprietary...

  6. Want to help build the tools to make `molecular movies' of protein machines?

    E-Print Network [OSTI]

    Uppsala Universitet

    Want to help build the tools to make `molecular movies' of protein machines? When: Research Research Topic: We are looking for a highly motivated student to help build a state-of-the-art single and instrument control would be highly desirable, but is not required. § A chance to help develop imaging tools

  7. Thoughts on Prospects for New Characterization Tools

    SciTech Connect (OSTI)

    Gaspar, Dan; Baer, Donald R.

    2007-09-20T23:59:59.000Z

    One of the key challenges for many imaging characterization methods is in preparing samples. For instance, TEM sample preparation for complex structures or soft materials is currently time consuming and expensive. Improving the throughput and decreasing the cost of key technologies such as focused ion beam (FIB) and cryo-ultramicrotoming sample preparation would aid in accelerating nanoscale research in soft materials, complex structures and at the intersection of biology and nanotechnology.

  8. Intrusion detection sensor testing tools

    SciTech Connect (OSTI)

    Hayward, D.R.

    1994-08-01T23:59:59.000Z

    Intrusion detection sensors must be frequently tested to verify that they are operational, and they must be periodically tested to verify that they are functioning at required performance levels. Concerns involving this testing can include: The significant amount of manpower required, inconsistent results due to variability in methods and personnel, exposure of personnel to hazardous environments, and difficulty in obtaining access to the areas containing some of the intrusion sensors. To address these concerns, the Department of Energy directed Sandia National Labs. to develop intrusion detection sensor testing tools. Over the past two years Sandia has developed several sensor testing tool prototypes. This paper describes the evolution of an exterior intrusion detection sensor tester and automatic data logger, and also describes various interior intrusion detection sensor test fixtures that can be remotely activated to simulate an intruder.

  9. Toole County Secondary Data Analysis

    E-Print Network [OSTI]

    Maxwell, Bruce D.

    Infarction prevalence (Heart Attack) 4.4% 4.1% 6.0% All Sites Cancer 461.9 455.5 543.2 1 Community) Leading Causes of Death County1 Montana1,2 Nation2 1. Heart Disease 2. Cancer 3. CLRD* 1. Cancer 2. Heart Disease 3.CLRD* 1. Heart Disease 2. Cancer 3. CLRD* #12; Toole County Secondary Data

  10. High performance computing Igal G. Rasin

    E-Print Network [OSTI]

    Adler, Joan

    High performance computing Igal G. Rasin Department of Chemical Engineering, Technion Israel with different parallelization techniques and tools used in high performance computing (HPC). The tutorial

  11. APS Guideline for Hand Tool and Portable Power Tool Usage

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLasDelivered‰PNGExperience4AJ01) (See95TI07)Operations2AP-XPSAPS Floor Coordinators APSHand Tool

  12. Interactive graphical tools for three-dimensional mesh redistribution

    SciTech Connect (OSTI)

    Dobbs, L.A.

    1996-03-01T23:59:59.000Z

    Three-dimensional meshes modeling nonlinear problems such as sheet metal forming, metal forging, heat transfer during welding, the propagation of microwaves through gases, and automobile crashes require highly refined meshes in local areas to accurately represent areas of high curvature, stress, and strain. These locally refined areas develop late in the simulation and/or move during the course of the simulation, thus making it difficult to predict their exact location. This thesis is a systematic study of new tools scientists can use with redistribution algorithms to enhance the solution results and reduce the time to build, solve, and analyze nonlinear finite element problems. Participatory design techniques including Contextual Inquiry and Design were used to study and analyze the process of solving such problems. This study and analysis led to the in-depth understanding of the types of interactions performed by FEM scientists. Based on this understanding, a prototype tool was designed to support these interactions. Scientists participated in evaluating the design as well as the implementation of the prototype tool. The study, analysis, prototype tool design, and the results of the evaluation of the prototype tool are described in this thesis.

  13. Ultratech Develops an Improved Lithography Tool for LED Wafer Manufacturing

    Broader source: Energy.gov [DOE]

    Ultratech modified an existing lithography tool used for semiconductor manufacturing to better meet the cost and performance targets of the high-brightness LED manufacturing industry. The goal was to make the equipment compatible with the wide range of substrate diameters and thicknesses prevalent in the industry while reducing the capital cost and the overall cost of ownership (COO).

  14. Built Environment Analysis Tool: April 2013

    SciTech Connect (OSTI)

    Porter, C.

    2013-05-01T23:59:59.000Z

    This documentation describes the tool development. It was created to evaluate the effects of built environment scenarios on transportation energy and greenhouse gas (GHG) emissions. This documentation also provides guidance on how to apply the tool.

  15. Remixing physical objects through tangible tools

    E-Print Network [OSTI]

    Follmer, Sean (Sean Weston)

    2011-01-01T23:59:59.000Z

    In this document we present new tools for remixing physical objects. These tools allow users to copy, edit and manipulate the properties of one or more objects to create a new physical object. We already have these ...

  16. Optimization of nave dynamic binary instrumentation Tools/

    E-Print Network [OSTI]

    Kleckner, Reid (Reid N.)

    2011-01-01T23:59:59.000Z

    The proliferation of dynamic program analysis tools has done much to ease the burden of developing complex software. However, creating such tools remains a challenge. Dynamic binary instrumentation frameworks such as ...

  17. Material feedback in digital design tools

    E-Print Network [OSTI]

    Stanton, Christian J

    2009-01-01T23:59:59.000Z

    How do design tools feedback material behavior to the designer? Digital design tools in use by designers today provide a rich environment for design of form but offer little feedback of the material that ultimately realize ...

  18. Alternative Fuels Data Center: Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May Jun Jul(Summary)morphinanInformation InInformationCenterResearch HighlightsTools Printable Version Share this resource Send a

  19. The Xygra gun simulation tool.

    SciTech Connect (OSTI)

    Garasi, Christopher Joseph; Lamppa, Derek C.; Aubuchon, Matthew S.; Shirley, David Noyes; Robinson, Allen Conrad; Russo, Thomas V.

    2008-12-01T23:59:59.000Z

    Inductive electromagnetic launchers, or coilguns, use discrete solenoidal coils to accelerate a coaxial conductive armature. To date, Sandia has been using an internally developed code, SLINGSHOT, as a point-mass lumped circuit element simulation tool for modeling coilgun behavior for design and verification purposes. This code has shortcomings in terms of accurately modeling gun performance under stressful electromagnetic propulsion environments. To correct for these limitations, it was decided to attempt to closely couple two Sandia simulation codes, Xyce and ALEGRA, to develop a more rigorous simulation capability for demanding launch applications. This report summarizes the modifications made to each respective code and the path forward to completing interfacing between them.

  20. mirabootcamp-tools-2014.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE:1 First Use of Energy for All Purposes (Fuel and Nonfuel),Feet) Year Jan Feb Mar Apr May JunDatastreamsmmcrcalgovInstrumentsrucLasDelivered energy consumption byAbout SRNLBuildings andExternal LinksBG/Q Performance Tools