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Sample records for hep research snowmass

  1. SNOWMASS (DPF Community Summer Study)

    SciTech Connect (OSTI)

    Cronin-Hennessy, et al, Daniel

    2013-08-06

    The 2013 Community Summer Study, known as Snowmass," brought together nearly 700 physicists to identify the critical research directions for the United States particle physics program. Commissioned by the American Physical Society, this meeting was the culmination of intense work over the past year by more than 1000 physicists that defined the most important questions for this field and identified the most promising opportunities to address them. This Snowmass study report is a key resource for setting priorities in particle physics.

  2. Snowmass Computing Frontier I2: Distributed

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    panelists from different parts of the grid world: operations, technology, security, big thinking Snowmass report will summarize the discussion Listened carefully to...

  3. pMSSM Benchmark Models for Snowmass 2013 (Journal Article) |...

    Office of Scientific and Technical Information (OSTI)

    Journal Article: pMSSM Benchmark Models for Snowmass 2013 Citation Details In-Document Search Title: pMSSM Benchmark Models for Snowmass 2013 Authors: Cahill-Rowley, Matthew W. ; ...

  4. HEP Budget | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Budget High Energy Physics (HEP) HEP Home About Organization Chart .pdf file (106KB) Staff HEP Budget HEP Committees of Visitors Directions Jobs University Research & National Labs ...

  5. 2001 Snowmass Accelerator R & D report (Conference) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Citation Details In-Document Search Title: 2001 Snowmass Accelerator R & D report Authors: Chao, Alexander ; Davidson, Ronald ; Dragt, Alexander ; Dugan, Gerald ; Holtkamp, Norbert ...

  6. HEP Committees of Visitors | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Committees of Visitors High Energy Physics (HEP) HEP Home About Organization Chart .pdf file (106KB) Staff HEP Budget HEP Committees of Visitors Directions Jobs University Research ...

  7. REPORT OF THE SNOWMASS M6 WORKING GROUP ON HIGH INTENSITY PROTON SOURCES.

    SciTech Connect (OSTI)

    CHOU,W.; WEI,J.

    2001-08-14

    The M6 working group had more than 40 active participants (listed in Section 4). During the three weeks at Snowmass, there were about 50 presentations, covering a wide range of topics associated with high intensity proton sources. The talks are listed in Section 5. This group also had joint sessions with a number of other working groups, including E1 (Neutrino Factories and Muon Colliders), E5 (Fixed-Target Experiments), M1 (Muon Based Systems), T4 (Particle Sources), T5 (Beam dynamics), T7 (High Performance Computing) and T9 (Diagnostics). The M6 group performed a survey of the beam parameters of existing and proposed high intensity proton sources, in particular, of the proton drivers. The results are listed in Table 1. These parameters are compared with the requirements of high-energy physics users of secondary beams in Working Groups E1 and E5. According to the consensus reached in the E1 and E5 groups, the U.S. HEP program requires an intense proton source, a 1-4 MW Proton Driver, by the end of this decade.

  8. Linear Collider Physics Resource Book Snowmass 2001

    SciTech Connect (OSTI)

    Ronan , M.T.

    2001-06-01

    The American particle physics community can look forward to a well-conceived and vital program of experimentation for the next ten years, using both colliders and fixed target beams to study a wide variety of pressing questions. Beyond 2010, these programs will be reaching the end of their expected lives. The CERN LHC will provide an experimental program of the first importance. But beyond the LHC, the American community needs a coherent plan. The Snowmass 2001 Workshop and the deliberations of the HEPAP subpanel offer a rare opportunity to engage the full community in planning our future for the next decade or more. A major accelerator project requires a decade from the beginning of an engineering design to the receipt of the first data. So it is now time to decide whether to begin a new accelerator project that will operate in the years soon after 2010. We believe that the world high-energy physics community needs such a project. With the great promise of discovery in physics at the next energy scale, and with the opportunity for the uncovering of profound insights, we cannot allow our field to contract to a single experimental program at a single laboratory in the world. We believe that an e{sup +}e{sup -} linear collider is an excellent choice for the next major project in high-energy physics. Applying experimental techniques very different from those used at hadron colliders, an e{sup +}e{sup -} linear collider will allow us to build on the discoveries made at the Tevatron and the LHC, and to add a level of precision and clarity that will be necessary to understand the physics of the next energy scale. It is not necessary to anticipate specific results from the hadron collider programs to argue for constructing an e{sup +}e{sup -} linear collider; in any scenario that is now discussed, physics will benefit from the new information that e{sup +}e{sup -} experiments can provide. This last point merits further emphasis. If a new accelerator could be designed and

  9. HEP-NERSCWorkshop.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP/NERSC Requirements Gathering Workshop Yukiko Sekine Program Manager, Facilities Division Advanced Scientific Computing Research Office of Science, DOE November 12 & 13, 2009 Advanced Scientific Computing Research Topics for Discussion * Current approaches to NERSC requirements gathering * Benefits of SC/HQ-centric requirements gathering for NERSC resources in the context of Programmatic mission needs * 2009 NERSC requirements gathering workshop schedule * An example outcome from

  10. pMSSM Benchmark Models for Snowmass 2013 (Journal Article) |...

    Office of Scientific and Technical Information (OSTI)

    National Accelerator Laboratory (SLAC) Sponsoring Org: US DOE Office of Science (DOE SC) Country of Publication: United States Language: English Subject: Experiment-HEP, ...

  11. HEP Early Career Opportunities | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Early Career Opportunities High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Closed Funding Opportunity Announcements (FOAs) Closed Lab Announcements Award Search / Public Abstracts HEP Early Career Opportunities Review Policy / Proposal Guidelines / Reporting Requirements Additional Requirements and Guidance for Digital Data Management Acknowledgements of Federal Support Advisory Committees Community Resources Contact

  12. HEP at Work | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Conference Rooms Computing Environment, Safety & Health Committees Wiki SharePoint Indico Travel Form Career Opportunities Staff Directory About HEP at Work Career Opportunities Staff Directory Argonne National Laboratory High Energy Physics Research Facilities Capabilities Initiatives Publications News & Events HEP at Work Conference Rooms Computing Environment, Safety & Health Committees Wiki SharePoint Indico Travel Form HEP at Work This page contains links to resources and tools

  13. LINEAR COLLIDER PHYSICS RESOURCE BOOK FOR SNOWMASS 2001.

    SciTech Connect (OSTI)

    ABE,T.; DAWSON,S.; HEINEMEYER,S.; MARCIANO,W.; PAIGE,F.; TURCOT,A.S.; ET AL

    2001-05-03

    The American particle physics community can look forward to a well-conceived and vital program of experimentation for the next ten years, using both colliders and fixed target beams to study a wide variety of pressing questions. Beyond 2010, these programs will be reaching the end of their expected lives. The CERN LHC will provide an experimental program of the first importance. But beyond the LHC, the American community needs a coherent plan. The Snowmass 2001 Workshop and the deliberations of the HEPAP subpanel offer a rare opportunity to engage the full community in planning our future for the next decade or more. A major accelerator project requires a decade from the beginning of an engineering design to the receipt of the first data. So it is now time to decide whether to begin a new accelerator project that will operate in the years soon after 2010. We believe that the world high-energy physics community needs such a project. With the great promise of discovery in physics at the next energy scale, and with the opportunity for the uncovering of profound insights, we cannot allow our field to contract to a single experimental program at a single laboratory in the world. We believe that an e{sup +}e{sup {minus}} linear collider is an excellent choice for the next major project in high-energy physics. Applying experimental techniques very different from those used at hadron colliders, an e{sup +}e{sup {minus}} linear collider will allow us to build on the discoveries made at the Tevatron and the LHC, and to add a level of precision and clarity that will be necessary to understand the physics of the next energy scale. It is not necessary to anticipate specific results from the hadron collider programs to argue for constructing an e{sup +}e{sup {minus}} linear collider; in any scenario that is now discussed, physics will benefit from the new information that e{sup +}e{sup {minus}} experiments can provide.

  14. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Presentations HEP Exascale Review Presentations Sort by: Default | Name | Date (low-high) | Date (high-low) | Source | Category HEP Requirements Review June 10, 2015 | Author(s): Barbara Helland, DOE ASCR | Download File: RequirementsreviewsHellandV3150610.pdf | pdf | 2.1 MB Opening Remarks June 10, 2015 | Author(s): Rob Roser, Salman Habib, Richard Gerber | Download File: HEP-ASCR-Exascale-opening-remarkssh.pdf | pdf | 187 KB P5 Science Drivers: Accelerator Experiments June 10, 2015 |

  15. HEP_Exaflop_brower

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Requirements Reviews: High Energy Physics Rich Brower (SciDAC software co-directorCUDA fellow) ... Lattice Field Theory has Come of Age HEP Need For Precision * Fundamental ...

  16. HEP Staff Directory | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Employee Spotlights About HEP at Work Career Opportunities Staff Directory Argonne National Laboratory High Energy Physics Research Facilities Capabilities Initiatives Publications News & Events Staff Directory Employee Spotlights HEP Staff Directory Name Title E-mail Abelof, Gabriel Joint Appointment Adams, Carolyn Electronic Technician cadams@anl.gov Anderson, John T. Principal Electronics Engineer Anthony, Michael Electronics Assistant mtanthony@anl.gov Arbelaez, Chrystian Posada

  17. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | 2.1 MB Opening Remarks June 10, 2015 | Author(s): Rob Roser, Salman Habib, Richard Gerber | Download File: HEP-ASCR-Exascale-opening-remarkssh.pdf | pdf | 187 KB Traditional...

  18. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | 2.1 MB Opening Remarks June 10, 2015 | Author(s): Rob Roser, Salman Habib, Richard Gerber | Download File: HEP-ASCR-Exascale-opening-remarkssh.pdf | pdf | 187 KB P5 Science...

  19. High Energy Physics (HEP) Homepage | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Programs » HEP Home High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » Intermediate Neutrino Research Program Awards ANNIE External link and PROSPECT External link will investigate the

  20. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Requirements Review June 10, 2015 | Author(s): Barbara Helland, DOE ASCR | Download File: RequirementsreviewsHellandV3150610.pdf | pdf | 2.1 MB Opening Remarks June 10, 2015 | Author(s): Rob Roser, Salman Habib, Richard Gerber | Download File: HEP-ASCR-Exascale-opening-remarkssh.pdf | pdf | 187 KB Traditional HPC needs: particle accelerators June 10, 2015 | Author(s): Jean-Luc Vay | Download File: DOEExascaleReviewVay.pdf | pdf | 19 MB P5 Science Drivers: Theory June 10, 2015 | Author(s):

  1. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALCF Future Systems June 10, 2015 | Author(s): Tim Williams | Download File: ExascaleReqsHEPALCF3systems.pdf | pdf | 3.1 MB ASCR Facility Plans June 10, 2015 | Author(s): Sudip Dosanjh | Download File: ASCR-Facilities-IntroHEP.pdf | pdf | 12 MB Computational Cosmology June 10, 2015 | Author(s): Katrin Heitmann | Download File: cosmohepascrheitmann.pdf | pdf | 6.5 MB Data Movement in HEP June 10, 2015 | Author(s): Brian Bockelman | Download File: Exascale-Data-Movement.pdf | pdf | 311 KB ESnet

  2. HEP-Tsung.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    F. S. Tsung, HEP Workshop Project Summary -- Simulations of Plasma Based Accelerator Experiments Around the World. UCLA/IST is making a strong effort to quickly deploy simulation modeling to experimental teams - Laboratory frame simulations of LWFA's in OSIRIS - Boosted frame simulations of LWFA's in OSIRIS - Laboratory frame simulations of LWFA/PWFA's in QuickPIC Plasma based accelerators can achieve accelerating gradients 1,000 x that of those created by conventional accelerators. Recently, 2

  3. HEP Computing | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Computing A number of computing resources are available for HEP employees and visitors. Problem Report or Service Request - Send email to the computing group and log it on the Problem Report Page. (Note: You need to be connected to the ANL network or to be running VPN to submit a problem report.) New Users or Visitors - Start here if you are new to Argonne HEP. Password Help Email Windows Desktops Laptops Linux Users HEP Division FAQs - Find answers for commonly requested information here.

  4. Amber_HEP-NERSC.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DOE HEP Program Perspective HEP/NERSC Workshop November 12, 2009 2 What is High Energy Physics? The High Energy Physics (HEP) program mission is to understand how the universe works at its most fundamental level. We do this by:  Discovering the most elementary constituents of matter and energy,  Probing the interactions between them,  And exploring the basic nature of space and time. 3 The Three Frontiers of HEP  At the Energy Frontier, powerful accelerators are used to create new

  5. Snowmass. Colorado,

    Office of Scientific and Technical Information (OSTI)

    data analysis methods, characterization of the test esplosive, and esperimental results. ... The present test program was performed on the Sandia National Laboratories (Albuquerque) ...

  6. cet091110-hep_hpc.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Detector Simulation and Analysis Craig E. Tull, Ph.D. Staff Scientist/Group Leader Science Software Systems Group Computational Research Division Berkeley Lab Computing Sciences November 12, 2009 Rockville, MD HEP-HCG | Rockville | November 12, 2009 1. Detector Simulation and Analysis Overview Summarize the projects in your science area and their scientific objectives for the next 3-5 years * Current and past users of NERSC: - ATLAS - LHC accelerator at CERN, Geneva (PI: Ian Hinchliff) - Daya

  7. Future HEP Accelerators: The US Perspective

    SciTech Connect (OSTI)

    Bhat, Pushpalatha; Shiltsev, Vladimir

    2015-11-02

    Accelerator technology has advanced tremendously since the introduction of accelerators in the 1930s, and particle accelerators have become indispensable instruments in high energy physics (HEP) research to probe Nature at smaller and smaller distances. At present, accelerator facilities can be classified into Energy Frontier colliders that enable direct discoveries and studies of high mass scale particles and Intensity Frontier accelerators for exploration of extremely rare processes, usually at relatively low energies. The near term strategies of the global energy frontier particle physics community are centered on fully exploiting the physics potential of the Large Hadron Collider (LHC) at CERN through its high-luminosity upgrade (HL-LHC), while the intensity frontier HEP research is focused on studies of neutrinos at the MW-scale beam power accelerator facilities, such as Fermilab Main Injector with the planned PIP-II SRF linac project. A number of next generation accelerator facilities have been proposed and are currently under consideration for the medium- and long-term future programs of accelerator-based HEP research. In this paper, we briefly review the post-LHC energy frontier options, both for lepton and hadron colliders in various regions of the world, as well as possible future intensity frontier accelerator facilities.

  8. Report of the Snowmass T4 working group on particle sources: Positron sources, anti-proton sources and secondary beams

    SciTech Connect (OSTI)

    N. Mokhov et al.

    2002-12-05

    This report documents the activities of the Snowmass 2001 T4 Particle Sources Working Group. T4 was charged with examining the most challenging aspects of positron sources for linear colliders and antiproton sources for proton-antiproton colliders, and the secondary beams of interest to the physics community that will be available from the next generation of high-energy particle accelerators. The leading issues, limiting technologies, and most important R and D efforts of positron production, antiproton production, and secondary beams are discussed in this paper. A listing of T4 Presentations is included.

  9. HEP Science Network Requirements--Final Report

    SciTech Connect (OSTI)

    Bakken, Jon; Barczyk, Artur; Blatecky, Alan; Boehnlein, Amber; Carlson, Rich; Chekanov, Sergei; Cotter, Steve; Cottrell, Les; Crawford, Glen; Crawford, Matt; Dart, Eli; Dattoria, Vince; Ernst, Michael; Fisk, Ian; Gardner, Rob; Johnston, Bill; Kent, Steve; Lammel, Stephan; Loken, Stewart; Metzger, Joe; Mount, Richard; Ndousse-Fetter, Thomas; Newman, Harvey; Schopf, Jennifer; Sekine, Yukiko; Stone, Alan; Tierney, Brian; Tull, Craig; Zurawski, Jason

    2010-04-27

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the US Department of Energy Office of Science, the single largest supporter of basic research in the physical sciences in the United States. In support of the Office of Science programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In August 2009 ESnet and the Office of High Energy Physics (HEP), of the DOE Office of Science, organized a workshop to characterize the networking requirements of the programs funded by HEP. The International HEP community has been a leader in data intensive science from the beginning. HEP data sets have historically been the largest of all scientific data sets, and the communty of interest the most distributed. The HEP community was also the first to embrace Grid technologies. The requirements identified at the workshop are summarized below, and described in more detail in the case studies and the Findings section: (1) There will be more LHC Tier-3 sites than orginally thought, and likely more Tier-2 to Tier-2 traffic than was envisioned. It it not yet known what the impact of this will be on ESnet, but we will need to keep an eye on this traffic. (2) The LHC Tier-1 sites (BNL and FNAL) predict the need for 40-50 Gbps of data movement capacity in 2-5 years, and 100-200 Gbps in 5-10 years for HEP program related traffic. Other key HEP sites include LHC Tier-2 and Tier-3 sites, many of which are located at universities. To support the LHC, ESnet must continue its collaborations with university and international networks. (3) While in all cases the deployed 'raw' network bandwidth must exceed the user requirements in order to meet the data transfer and reliability requirements, network engineering for trans-Atlantic connectivity

  10. HEP Final Project Report

    SciTech Connect (OSTI)

    Chen, Chunhui

    2013-05-21

    In this report, we summarize the research activity funded by the DOE award DE-FG02-12ER41827 (DE-SC0007892) during the funding period (May 1, 2012- March 31, 2013).

  11. HEP Open Funding Opportunities

    Office of Science (SC) Website

    - and is the principal federal funding agency of - the Nation's research programs in high-energy physics, nuclear physics, and fusion energy sciences. en 8BF3F791-EE84-4768-BCDF-E...

  12. HEP/NP Requirements Review 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP/NP Requirements Review 2013 Science Engagement Move your data Programs & Workshops Science Requirements Reviews Network Requirements Reviews Documents and Background Materials FAQ for Case Study Authors BER Requirements Review 2015 ASCR Requirements Review 2015 Previous Reviews HEP/NP Requirements Review 2013 HEP Attendees 2013 FES Requirements Review 2014 BES Requirements Review 2014 Requirements Review Reports Case Studies Contact Us Technical Assistance: 1 800-33-ESnet (Inside US) 1

  13. NERSC/DOE HEP Requirements Workshop Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | DOE HEP Overview November 12, 2009 | Author(s): Amber Boehnlein | Workshop Logistics November 12, 2009 | Author(s): Harvey Wasserman | NERSC Role in High Energy Physics...

  14. HEP BPI QCI Testing Reminders

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    HEP BPI QCI Testing Reminders Field Exams: * The video camera i s not to video you, but to listen to us as proctors * Use your field guide - make sure you talk about or demonstrate each item fully * If something doesn't look "right" (manometer, combustion analyzer etc..) check settings and if needed start over - this way you don't m iss a step or t ake the wrong readings * Consult correct BPI standards and m ake recommendations based o charts & action tables * Read f ully the

  15. University Research National Labs | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    About » University Research & National Labs » University Research National Labs Alpha Listing High Energy Physics (HEP) HEP Home About Organization Chart .pdf file (106KB) Staff HEP Budget HEP Committees of Visitors Directions Jobs University Research & National Labs University Research National Labs Alpha Listing Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department

  16. Using HEP Technology to Fight Cancer

    SciTech Connect (OSTI)

    Le Du, Patrick

    2004-06-30

    Many engineering and physics HEP groups are now collaborating with medical doctors and biomedical scientists to develop new modern and 'state of the art' radiation instruments for cancer diagnostics and treatment. This presentation will review some of these studies, oriented towards the imaging fields for diagnostic (Positron Emission Tomography and Computed Tomography) and particle therapy for tumor treatment (from proton to light ions). I will try, using appropriate examples, to show what are the challenges and where the development of HEP concepts, tools and techniques can be used.

  17. HEP-v2-for-dist

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Case S tudy: C on.nuing S tudies o f P lasma B ased Accelerators ( mp113) * PI: W. B. Mori (UCLA) * Presenter: F. S. Tsung (UCLA) Users: W. An, A. Davidson, V. K. Decyk, (UCLA), J. Vieira, L. Silva (IST), W. Lu (UCLA/ Tsinghua) F. S. Tsung, HEP Workshop HEP R equirements: Con.nuing S tudies o f P lasma B ased A ccelerators ( mp113) (PI: W . B . M ori, P resenter: F . S . T sung) An alternate scheme to accelerate particles using plasmas is the Plasma WakeField Accelerator (PWFA) concept where a

  18. Research | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    the Accelerator Stewardship program. HEP Research Subprograms Energy Frontier Energy Frontier ... Accelerator Stewardship coordinates with accelerator user communities and ...

  19. 2015-06-LATBauerdick-DOE-ASCR-HEP.key

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lothar A. T. Bauerdick
 U.S. CMS Operations Program Manager June 10, 2015 HEP Facility Plans LATBauerdick I DOE SC Exascale Requirements Reviews -High Energy Physics 06/10/15 Distributed Facilities and Sharing of Resources * Experimental HEP mostly uses distributed high-throughput computing ✦ Before LHC most of the computing and storage capacity was at a 
 central experiment data center ✦ now most HEP experiments have adopted distributed computing, with global workflow, scheduling, and

  20. Detector systems for future HEP experiments (Journal Article...

    Office of Scientific and Technical Information (OSTI)

    SciTech Connect Search Results Journal Article: Detector systems for future HEP ... OSTI Identifier: 21182524 Resource Type: Journal Article Resource Relation: Journal Name: ...

  1. White Paper on DOE-HEP Accelerator Modeling Science Activities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    modeling science within the Department of Energy (DOE) Office of High Energy Physics (HEP) and (b) increasing the community-wide coordination and integration of code development. ...

  2. HEP Budget | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Budget Budget Budget Home About Budget by Program ASCR Budget BES Budget BER Budget FES Budget HEP Budget NP Budget WDTS Budget SLI Budget S&S Budget SCPD Budget GAO Audit Reports External Links Contact Information Budget U.S. Department of Energy SC-41/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3541 F: (301) 903-9524 More Information » Budget by Program HEP Budget Print Text Size: A A A FeedbackShare Page The following links contain HEP's budget

  3. HEP Committees of Visitors | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEPAP Home HEP Committees of Visitors High Energy Physics Advisory Panel (HEPAP) HEPAP Home Meetings 2016 HEPAP Membership ChargesReports Charter .pdf file (44KB) HEP ...

  4. A high-elevation, multi-proxy biotic and environmental record of MIS 64 from the Ziegler Reservoir fossil site, Snowmass Village, Colorado, USA

    SciTech Connect (OSTI)

    Ian M. Miller; Mitchell A. Plummer; Various Others

    2014-10-01

    In North America, terrestrial records of biodiversity and climate change that span Marine Oxygen Isotope Stage (MIS) 5 are rare. Where found, they provide insight into how the coupling of the oceanatmosphere system is manifested in biotic and environmental records and how the biosphere responds to climate change. In 20102011, construction at Ziegler Reservoir near Snowmass Village, Colorado (USA) revealed a nearly continuous, lacustrine/wetland sedimentary sequence that preserved evidence of past plant communities between ~140 and 55 ka, including all of MIS 5. At an elevation of 2705 m, the Ziegler Reservoir fossil site also contained thousands of well-preserved bones of late Pleistocene megafauna, including mastodons, mammoths, ground sloths, horses, camels, deer, bison, black bear, coyotes, and bighorn sheep. In addition, the site contained more than 26,000 bones from at least 30 species of small animals including salamanders, otters, muskrats, minks, rabbits, beavers, frogs, lizards, snakes, fish, and birds. The combination of macro- and micro-vertebrates, invertebrates, terrestrial and aquatic plant macrofossils, a detailed pollen record, and a robust, directly dated stratigraphic framework shows that high-elevation ecosystems in the Rocky Mountains of Colorado are climatically sensitive and varied dramatically throughout MIS 5

  5. HEP Collider HPC Use, Prospects and Wishes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Collider HPC Use, Prospects and Wishes Tom L eCompte High E nergy P hysics D ivision Argonne N a4onal L aboratory 2 Outline § Overview o f t he S cience § Overview o f H PC u se T oday § Some E xtrapola?ons t o t he F uture I a m a n L HC e xperimenter. T his t alk i s a rranged a round t hat experience - a t t he p resent ? me, w e a re t he o nly m ajor experimental H EP g roup u sing H PCs a t t his s cale. 3 Collider Physics for Non-Physicists § We c ollide p ar?cles t

  6. FES BER HEP NP BES ASCR NERSC Science Highlights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    detail. (Saye, LBNL, Science Advances) High Energy Physics Model confirms existence of an ... Brown-Dwarf Companion to Accre*ng White Dwarf HEP PI: E. Baron (Univ. of Oklahoma) ...

  7. West Foster Creek Expansion Project 2007 HEP Report.

    SciTech Connect (OSTI)

    Ashley, Paul R.

    2008-02-01

    During April and May 2007, the Columbia Basin Fish and Wildlife Authority's (CBFWA) Regional HEP Team (RHT) conducted baseline Habitat Evaluation Procedures (HEP) (USFWS 1980, 1980a) analyses on five parcels collectively designated the West Foster Creek Expansion Project (3,756.48 acres). The purpose of the HEP analyses was to document extant habitat conditions and to determine how many baseline/protection habitat units (HUs) to credit Bonneville Power Administration (BPA) for funding maintenance and enhancement activities on project lands as partial mitigation for habitat losses associated with construction of Grand Coulee and Chief Joseph Dams. HEP evaluation models included mule deer (Odocoileus hemionus), western meadowlark (Sturnella neglecta), sharp-tailed grouse, (Tympanuchus phasianellus), Bobcat (Lynx rufus), mink (Neovison vison), mallard (Anas platyrhynchos), and black-capped chickadee (Parus atricapillus). Combined 2007 baseline HEP results show that 4,946.44 habitat units were generated on 3,756.48 acres (1.32 HUs per acre). HEP results/habitat conditions were generally similar for like cover types at all sites. Unlike crediting of habitat units (HUs) on other WDFW owned lands, Bonneville Power Administration received full credit for HUs generated on these sites.

  8. Building global HEP systems on Kerberos

    SciTech Connect (OSTI)

    Crawford, Matt; /Fermilab

    2004-12-01

    As an underpinning of AFS and Windows 2000, and as a formally proven security protocol [1] in its own right, Kerberos is ubiquitous among HEP sites. Fermilab and users from other sites have taken advantage of this and built a diversity of distributed applications over Kerberos v5. We present several projects in which this security infrastructure has been leveraged to meet the requirements of geographically dispersed collaborations. These range from straightforward ''Kerberization'' of applications such as database and batch services, to quick tricks like simulating a user-authenticated web service with AFS and the ''file'': schema, to more complex systems. Examples of the latter include experiment control room operations and the Central Analysis Farm (CAF). We present several use cases and their security models, and examine how they attempt to address some of the outstanding problems of secure distributed computing: delegation of the least necessary privilege; establishment of trust between a user and a remote processing facility; credentials for long-queued or long-running processes, and automated processes running without any user's presence; security of remotely-stored credentials; and ability to scale to the numbers of sites, machines and users expected in the collaborations of the coming decade.

  9. Shillapoo Wildlife Area 2007 Follow-up HEP Report.

    SciTech Connect (OSTI)

    Ashley, Paul R.

    2008-03-01

    In April and May 2007 the Regional HEP Team (RHT) conducted a follow-up HEP analysis on the Egger (612 acres) and Herzog (210 acres) parcels located at the north end of the Shillapoo Wildlife Area. The Egger and Herzog parcels have been managed with Bonneville Power Administration funds since acquired in 1998 and 2001 respectively. Slightly more than 936 habitat units (936.47) or 1.14 HUs per acre was generated as an outcome of the 2007 follow-up HEP surveys. Results included 1.65 black-capped chickadee HUs, 280.57 great blue heron HUs, 581.45 Canada goose HUs, 40 mallard HUs, and 32.80 mink HUs. Introduction A follow-up Habitat Evaluation Procedures (HEP) (USFWS 1980) analysis was conducted by the Columbia Basin Fish and Wildlife Authority's (CBFWA) Regional HEP Team (RHT) during April and May 2007 to document changes in habitat quality and to determine the number of habitat units (HUs) to credit Bonneville Power Administration (BPA) for providing operation and maintenance (O&M) funds since WDFW acquired the parcels. The 2007 follow-up HEP evaluation was limited to Shillapoo Wildlife Area (SWA) parcels purchased with Bonneville Power Administration funds. D. Budd (pers. comm.) reported WDFW purchased the 612 acre Egger Farms parcel on November 2, 1998 for $1,737,0001 and the 210 acre Herzog acquisition on June 21, 2001 for $500,000 with Memorandum of Agreement funds (BPA and WDFW 1996) as partial fulfillment of BPA's wildlife mitigation obligation for construction of Bonneville and John Day Dams (Rasmussen and Wright 1989). Anticipating the eventual acquisition of the Egger and Herzog properties, WDFW conducted HEP surveys on these lands in 1994 to determine the potential number of habitat units to be credited to BPA. As a result, HEP surveys and habitat unit calculations were completed as much as seven years prior to acquiring the sites. The term 'Shillapoo Wildlife Area' will be used to describe only the Herzog and Egger parcels in this document. Details and

  10. Sensor Compendium - A Snowmass Whitepaper-

    SciTech Connect (OSTI)

    Artuso, M.; Battaglia, M.; Bolla, G.; Bortoletto, D.; Caberera, B.; Carlstrom, J E; Chang, C. L.; Cooper, W.; Da Via, C.; Demarteau, M.; Fast, J.; Frisch, H.

    2013-10-01

    Sensors play a key role in detecting both charged particles and photons for all three frontiers in Particle Physics. The signals from an individual sensor that can be used include ionization deposited, phonons created, or light emitted from excitations of the material. The individual sensors are then typically arrayed for detection of individual particles or groups of particles. Mounting of new, ever higher performance experiments, often depend on advances in sensors in a range of performance characteristics. These performance metrics can include position resolution for passing particles, time resolution on particles impacting the sensor, and overall rate capabilities. In addition the feasible detector area and cost frequently provides a limit to what can be built and therefore is often another area where improvements are important. Finally, radiation tolerance is becoming a requirement in a broad array of devices. We present a status report on a broad category of sensors, including challenges for the future and work in progress to solve those challenges.

  11. An Object-oriented minimization package for HEP

    SciTech Connect (OSTI)

    Mark S Fischler and David Sachs

    2003-07-02

    A portion of the HEP community has perceived the need for a minimization package written in C++ and taking advantage of the Object-Oriented nature of that language. To be acceptable for HEP, such a package must at least encompass all the capabilities of Minuit. Aside from the slight plus of not relying on outside Fortran compilation, the advantages that a C++ package based on O-O design would confer over the multitude of available C++ Minuit-wrappers include: Easier extensibility to different algorithms and forms of constraints; and usage modes which would not be available in the global-common-based Minuit design. An example of the latter is a job pursuing two ongoing minimization problems simultaneously. We discuss the design and implementation of such a package, which extends Minuit only in minor ways but which greatly diminishes the programming effort (if not the algorithm thought) needed to make more significant extensions.

  12. Katrin Heitmann DOE HEP/ASCR Exascale Requirements Review

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Katrin Heitmann DOE HEP/ASCR Exascale Requirements Review June 10, 2015 Computational Cosmology Katrin Heitmann, Los Alamos National Laboratory Benasque Cosmology Workshop, August 2010 Roles of Cosmological Simulations in DE Survey Science * First part of end-to-end simulation * Control of systematics (1) Cosmology simulations and the survey (2) Solving the Inverse Problem from the LSST Science Book Cosmology Mock catalogs Athmosphere Optics Detector Images * Exploring fundamental physics *

  13. HEP-FCE Working Group on Libraries and Tools

    SciTech Connect (OSTI)

    Borgland, Anders; Elmer, Peter; Kirby, Michael; Patton, Simon; Potekhin, Maxim; Viren, Brett; Yanny, Brian

    2014-12-19

    The High-Energy Physics Forum for Computational Excellence (HEP-FCE) was formed by the Department of Energy as a follow-up to a recent report from the Topical Panel on Computing[1] and the associated P5 recommendation[2]. It is a pilot project distributed across the DOE Labs. During this initial incubation period the Forum is to develop a plan for a robust, long-term organization structure and a functioning web presence for forum activities and outreach, and a study of hardware and software needs across the HEP program. In the following sections we give this working group’s “vision” for aspects and qualities we wish to see in a future HEP-FCE. We then give a prioritized list of technical activities with suggested scoping and deliverables that can be expected to provide cross-experiment benefits. The remaining bulk of the report gives a technical survey of some specific “areas of opportunity” for cross-experiment benefit in the realm of software libs/tools. This survey serves as support for the vision and prioritized list. For each area we describe the ways that cross-experiment benefit is achieved today, as well as describe known failings or pitfalls where such benefit has failed to be achieved and which should be avoided in the future. For both cases, we try to give concrete examples. Each area then ends with an examination of what opportunities exist for improvements in that particular area.

  14. Langston University - High Energy Physics (LU-HEP)

    SciTech Connect (OSTI)

    Snow, Dr., Joel

    2012-08-13

    as MC production coordinator MC production increased very significantly. In the first year of the PI's tenure as production coordinator production was 159M events and 6.7~TB of data. During the last year of the project period production was 2,342~M events and 262~TB of data. That is a factor of 15 increase in events and 39 in data volume. The increase occurred with improvements in computer hardware and networks, through the use of grid technology on diverse resources, and through increased automation and efficiency of the production process. LU HEP developed and deployed the automatic MC request processing system in use at FNAL. The complementary strategies of automation and grid production served DZero well. Fermilab has recognized LU HEP's contribution to DZero by allowing the PI to devote full time to research activities by appointing him a guest scientist for the last six years of the project period.

  15. HEP Supported Workshops & Conferences | U.S. DOE Office of Science...

    Office of Science (SC) Website

    to learn more about a HEP-supported workshop or conference. Accelerators for America's Future External link Particle Accelerator Conference 2011 (PAC11) External link Fundamental...

  16. Measurements of the {sup 6}He+p resonant scattering

    SciTech Connect (OSTI)

    Condori, R. Pampa; Lichtenthler, R.; Lpine-Szily, A.; Gasques, L. R.; Morais, M. C.; Scarduelli, V. B.; Leistenschneider, E.; Alcntara-Nez, J. A.; Faria, P. N. de; Mendes Jr, D. R.; Pires, K. C. C.; Shorto, J. M. B.

    2014-11-11

    Measurements of the p({sup 6}He,p) elastic scattering excitation function have been performed in the RIBRAS system using a {sup 6}He secondary beam and a CH{sub 2} polyethylene thick target. The motivation is to observe states of the compound nucleus {sup 7}Li in the excitation energy range of E{sub exc}{sup 7Li}?=?10.8-11.8MeV, where the isobaric analog state of {sup 7}He ground state lies. Excitation functions have been obtained at three laboratory angles ?{sub lab} = 0, 20, and 25 which correspond to ?{sub c.m} = 180, 140, and 130.

  17. HEP Committees of Visitors | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Committees of Visitors HEP Committees of Visitors Print Text Size: A A A FeedbackShare Page High Energy Physics Advisory Panel (HEPAP) The links below provide an archive of High ...

  18. HEP User Facilities | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP User Facilities User Facilities User Facilities Home User Facilities at a Glance All User Facilities ASCR User Facilities BES User Facilities BER User Facilities FES User Facilities HEP User Facilities NP User Facilities User Resources User Statistics Policies and Processes Frequently Asked Questions User Facility Science Highlights User Facility News Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 P: (202) 586-5430 User

  19. Habitat Evaluation Procedures (HEP) Report : Grand Coulee Dam Mitigation, 1996-1999 Technical Report.

    SciTech Connect (OSTI)

    Kieffer, B.; Singer, Kelly; Abrahamson, Twa-le

    1999-07-01

    The purpose of this Habitat Evaluation Procedures (HEP) study was to determine baseline habitat units and to estimate future habitat units for Bonneville Power Administration (BPA) mitigation projects on the Spokane Indian Reservation. The mitigation between BPA and the Spokane Tribe of Indians (STOI) is for wildlife habitat losses on account of the construction of Grand Coulee Dam. Analysis of the HEP survey data will assist in mitigation crediting and appropriate management of the mitigation lands.

  20. Study of a Docker Use-Case for HEP

    SciTech Connect (OSTI)

    Kowalkowski, Jim; Lyon, Adam; Paterno, Marc

    2016-01-01

    Over the past few years, container technology has become increasingly promising as a means to seamlessly make our software available across a wider range of platforms. In December 2015, we decided to put together a set of docker images that serve as a demonstration of this container technology for managing a run-time environment for art-related software projects, and also serve as a set of test cases for evaluation of performance. Docker[1] containers provide a way to “wrap up a piece of software in a complete filesystem that contains everything it needs to run”. In combination with Shifter[2], such containers provide a way to run software developed and deployed on “typical” HEP platforms (such as SLF 6, in common use at Fermilab and on OSG platforms) on HPC facilities at NERSC. Docker containers provide a means of delivering software that can be run on a variety of hosts without needing to be compiled specially for each OS to be supported. This could substantially reduce the effort required to create and validate a new release, since one build could be suitable for use on both grid machines (both FermiGrid and OSG) as well as any machine capable of running the Docker container. In addition, docker containers may provide for a quick and easy way for users to install and use a software release in a standardized environment. This report contains the results and status of this demonstration and evaluation.

  1. BES-HEP Connections: Common Problems in Condensed Matter and High Energy Physics, Round Table Discussion

    SciTech Connect (OSTI)

    Fradkin, Eduardo; Maldacena, Juan; Chatterjee, Lali; Davenport, James W

    2015-02-02

    On February 2, 2015 the Offices of High Energy Physics (HEP) and Basic Energy Sciences (BES) convened a Round Table discussion among a group of physicists on ‘Common Problems in Condensed Matter and High Energy Physics’. This was motivated by the realization that both fields deal with quantum many body problems, share many of the same challenges, use quantum field theoretical approaches and have productively interacted in the past. The meeting brought together physicists with intersecting interests to explore recent developments and identify possible areas of collaboration.... Several topics were identified as offering great opportunity for discovery and advancement in both condensed matter physics and particle physics research. These included topological phases of matter, the use of entanglement as a tool to study nontrivial quantum systems in condensed matter and gravity, the gauge-gravity duality, non-Fermi liquids, the interplay of transport and anomalies, and strongly interacting disordered systems. Many of the condensed matter problems are realizable in laboratory experiments, where new methods beyond the usual quasi-particle approximation are needed to explain the observed exotic and anomalous results. Tools and techniques such as lattice gauge theories, numerical simulations of many-body systems, and tensor networks are seen as valuable to both communities and will likely benefit from collaborative development.

  2. Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells

    SciTech Connect (OSTI)

    Sekiya, Mika; Hiraishi, Ako; Touyama, Maiko [Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8572 (Japan); Sakamoto, Kazuichi [Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8572 (Japan)], E-mail: sakamoto@biol.tsukuba.ac.jp

    2008-10-31

    SREBP1c (sterol regulatory element-binding protein 1c) is a metabolic-syndrome-associated transcription factor that controls fatty acid biosynthesis under glucose/insulin stimulation. Oxidative stress increases lipid accumulation, which promotes the generation of reactive oxygen species (ROS). However, we know little about the role of oxidative stress in fatty acid biosynthesis. To clarify the action of oxidative stress in lipid accumulation via SREBP1c, we examined SREBP1c activity in H{sub 2}O{sub 2}-treated mammalian cells. We introduced a luciferase reporter plasmid carrying the SREBP1c-binding site into HepG2 or COS-7 cells. With increasing H{sub 2}O{sub 2} dose, SREBP1c transcriptional activity increased in HepG2 cells but declined in COS-7 cells. RT-PCR analysis revealed that mRNA expression of SREBP1c gene or of SREBP1c-regulated genes rose H{sub 2}O{sub 2} dose-dependently in HepG2 cells but dropped in COS-7 cells. Lipid accumulation and levels of the nuclear form of SREBP1c increased in H{sub 2}O{sub 2}-stimulated HepG2 cells. ROS may stimulate lipid accumulation in HepG2 cells via SREBP1c activation.

  3. HepSim: A Repository with Predictions for High-Energy Physics Experiments

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Chekanov, S. V.

    2015-01-01

    A file repository for calculations of cross sections and kinematic distributions using Monte Carlo generators for high-energy collisions is discussed. The repository is used to facilitate effective preservation and archiving of data from theoretical calculations and for comparisons with experimental data. The HepSim data library is publicly accessible and includes a number of Monte Carlo event samples with Standard Model predictions for current and future experiments. The HepSim project includes a software package to automate the process of downloading and viewing online Monte Carlo event samples. Data streaming over a network for end-user analysis is discussed.

  4. West Foster Creek 2007 Follow-up Habitat Evaluation Procedures (HEP) Report.

    SciTech Connect (OSTI)

    Ashley, Paul R.

    2008-02-01

    A follow-up habitat evaluation procedures (HEP) analysis was conducted on the West Foster Creek (Smith acquisition) wildlife mitigation site in May 2007 to determine the number of additional habitat units to credit Bonneville Power Administration (BPA) for providing funds to enhance and maintain the project site as partial mitigation for habitat losses associated with construction of Grand Coulee Dam. The West Foster Creek 2007 follow-up HEP survey generated 2,981.96 habitat units (HU) or 1.51 HUs per acre for a 34% increase (+751.34 HUs) above baseline HU credit (the 1999 baseline HEP survey generated 2,230.62 habitat units or 1.13 HUs per acre). The 2007 follow-up HEP analysis yielded 1,380.26 sharp-tailed grouse (Tympanuchus phasianellus) habitat units, 879.40 mule deer (Odocoileus hemionus) HUs, and 722.29 western meadowlark (Sturnella neglecta) habitat units. Mule deer and sharp-tailed grouse habitat units increased by 346.42 HUs and 470.62 HUs respectively over baseline (1999) survey results due largely to cessation of livestock grazing and subsequent passive restoration. In contrast, the western meadowlark generated slightly fewer habitat units in 2007 (-67.31) than in 1999, because of increased shrub cover, which lowers habitat suitability for that species.

  5. Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Research Isotopes produced at Los Alamos National Laboratory are saving lives, advancing cutting-edge research and keeping the U.S. safe. Research thorium test foil A thorium test foil target for proof-of-concept actinium-225 production In addition to our routine isotope products, the LANL Isotope Program is focused on developing the next suite of isotopes and services to meet the Nation's emerging needs. The LANL Isotope Program's R&D strategy is focused on four main areas (see

  6. FES BER HEP NP BES ASCR NERSC Science Highlights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    March 2016 Science Highlights March 2016 Energy & Environment Simula'ons support findings that migra'on of liquids and gases due to fracking have not had a widespread impact on drinking water. (Moridis , LBNL, Water Resources Research) Climate Researchers have reduced the 'me needed to detect important features in large climate datasets from years to hours. (O'Brien, LBNL. Env. Sci. & Tech) High Energy Physics New tools handle increasingly large datasets produced by ATLAS experiments at

  7. Research

    SciTech Connect (OSTI)

    1999-10-01

    Subjects covered in this section are: (1) PCAST panel promotes energy research cooperation; (2) Letter issued by ANS urges funding balance in FFTF restart consideration and (3) FESAC panel releases report on priorities and balance.

  8. Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The LANL Isotope Program's R&D strategy is focused on four main areas (see article list below for recent efforts in these areas): Medical Applications are a key focus for research ...

  9. Constraints on Higgs Properties and SUSY Partners in the pMSSM...

    Office of Scientific and Technical Information (OSTI)

    Resource Relation: Conference: Contributed to the Community Summer Stury 2013: Snowmass on the Mississippi (CSS 2013), 29 Jul - 6 Aug 2013. Minneapolis, MN, USA Research Org: SLAC ...

  10. Silica bioreplication preserves three-dimensional spheroid structures of human pluripotent stem cells and HepG2 cells

    SciTech Connect (OSTI)

    Lou, Yan-Ru; Kanninen, Liisa; Kaehr, Bryan; Townson, Jason L.; Niklander, Johanna; Harjumäki, Riina; Jeffrey Brinker, C.; Yliperttula, Marjo

    2015-09-01

    Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, they are increasingly employed as models for cancer and drug research, as well as tissue engineering. It has proven challenging to stabilize spheroid architectures for detailed morphological examination. Here we overcome this issue using a silica bioreplication (SBR) process employed on spheroids formed from human pluripotent stem cells (hPSCs) and hepatocellular carcinoma HepG2 cells cultured in the nanofibrillar cellulose (NFC) hydrogel. The cells in the spheroids are more round and tightly interacting with each other than those in 2D cultures, and they develop microvilli-like structures on the cell membranes as seen in 2D cultures. Furthermore, SBR preserves extracellular matrix-like materials and cellular proteins. In conclusion, these findings provide the first evidence of intact hPSC spheroid architectures and similar fine structures to 2D-cultured cells, providing a pathway to enable our understanding of morphogenesis in 3D cultures.

  11. Silica bioreplication preserves three-dimensional spheroid structures of human pluripotent stem cells and HepG2 cells

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lou, Yan-Ru; Kanninen, Liisa; Kaehr, Bryan; Townson, Jason L.; Niklander, Johanna; Harjumäki, Riina; Jeffrey Brinker, C.; Yliperttula, Marjo

    2015-09-01

    Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, they are increasingly employed as models for cancer and drug research, as well as tissue engineering. It has proven challenging to stabilize spheroid architectures for detailed morphological examination. Here we overcome this issue using a silica bioreplication (SBR) process employed on spheroids formed from human pluripotent stem cells (hPSCs) and hepatocellular carcinoma HepG2 cells cultured in the nanofibrillar cellulose (NFC) hydrogel. The cells in the spheroids are more round and tightly interacting with each other than thosemore » in 2D cultures, and they develop microvilli-like structures on the cell membranes as seen in 2D cultures. Furthermore, SBR preserves extracellular matrix-like materials and cellular proteins. In conclusion, these findings provide the first evidence of intact hPSC spheroid architectures and similar fine structures to 2D-cultured cells, providing a pathway to enable our understanding of morphogenesis in 3D cultures.« less

  12. High-Performance Secure Database Access Technologies for HEP Grids

    SciTech Connect (OSTI)

    Matthew Vranicar; John Weicher

    2006-04-17

    The Large Hadron Collider (LHC) at the CERN Laboratory will become the largest scientific instrument in the world when it starts operations in 2007. Large Scale Analysis Computer Systems (computational grids) are required to extract rare signals of new physics from petabytes of LHC detector data. In addition to file-based event data, LHC data processing applications require access to large amounts of data in relational databases: detector conditions, calibrations, etc. U.S. high energy physicists demand efficient performance of grid computing applications in LHC physics research where world-wide remote participation is vital to their success. To empower physicists with data-intensive analysis capabilities a whole hyperinfrastructure of distributed databases cross-cuts a multi-tier hierarchy of computational grids. The crosscutting allows separation of concerns across both the global environment of a federation of computational grids and the local environment of a physicist’s computer used for analysis. Very few efforts are on-going in the area of database and grid integration research. Most of these are outside of the U.S. and rely on traditional approaches to secure database access via an extraneous security layer separate from the database system core, preventing efficient data transfers. Our findings are shared by the Database Access and Integration Services Working Group of the Global Grid Forum, who states that "Research and development activities relating to the Grid have generally focused on applications where data is stored in files. However, in many scientific and commercial domains, database management systems have a central role in data storage, access, organization, authorization, etc, for numerous applications.” There is a clear opportunity for a technological breakthrough, requiring innovative steps to provide high-performance secure database access technologies for grid computing. We believe that an innovative database architecture where the

  13. Habitat Evaluation Procedures (HEP) Report : Hellsgate Project, 1999-2000 Technical Report.

    SciTech Connect (OSTI)

    Berger, Matthew

    2000-05-01

    A Habitat Evaluation Procedure (HEP) study was conducted on lands acquired and/or managed (4,568 acres total) by the Hellsgate Big Game Winter Range Wildlife Mitigation Project (Hellsgate project) to mitigate some of the losses associated with the original construction and operation of Grand Coulee Dam and inundation of habitats behind the dams. Three separate properties, totaling 2,224 acres were purchased in 1998. One property composed of two separate parcels, mostly grassland lies southeast of the town of Nespelem in Okanogan County (770 acres) and was formerly called the Hinman property. The former Hinman property lies within an area the Tribes have set aside for the protection and preservation of the sharp-tailed grouse (Agency Butte unit). This special management area minus the Hinman acquisition contains 2,388 acres in a long-term lease with the Tribes. The second property lies just south of the Silver Creek turnoff (Ferry County) and is bisected by the Hellsgate Road (part of the Friedlander unit). This parcel contains 60 acres of riparian and conifer forest cover. The third property (now named the Sand Hills unit) acquired for mitigation (1,394 acres) lies within the Hellsgate Reserve in Ferry County. This new acquisition links two existing mitigation parcels (the old Sand Hills parcels and the Lundstrum Flat parcel, all former Kuehne purchases) together forming one large unit. HEP team members included individuals from the Colville Confederated Tribes Fish and Wildlife Department (CTCR), Washington Department of Fish and Wildlife (WDFW), and Bureau of Land Management (BLM). The HEP team conducted a baseline habitat survey using the following HEP species models: mule deer (Odocoileus hemionus), mink (Mustela vison), downy woodpecker (Picoides pubescens), bobcat (Lynx rufus), yellow warbler (Dendroica petechia), and sharp-tailed grouse (Tympanuchus phasianellus columbianus). HEP analysis and results are discussed within the body of the text. The cover types

  14. Habitat Evaluation Procedures (HEP) Report; Precious Lands Wildlife Management Area, Technical Report 2000-2003.

    SciTech Connect (OSTI)

    Kozusko, Shana

    2003-12-01

    The Nez Perce Tribe (NPT) currently manages a 15,325 acre parcel of land known as the Precious Lands Wildlife Management Area that was purchased as mitigation for losses incurred by construction of the four lower Snake River dams. The Management Area is located in northern Wallowa County, Oregon and southern Asotin County, Washington (Figure 1). It is divided into three management parcels--the Buford parcel is located on Buford Creek and straddles the WA-OR state line, and the Tamarack and Basin parcels are contiguous to each other and located between the Joseph Creek and Cottonwood Creek drainages in Wallowa County, OR. The project was developed under the Pacific Northwest Electric Power Planning and Conservation Act of 1980 (P.L. 96-501), with funding from the Bonneville Power Administration (BPA). The acreage protected under this contract will be credited to BPA as habitat permanently dedicated to wildlife and wildlife mitigation. A modeling strategy known as Habitat Evaluation Procedure (HEP) was developed by the U.S. Fish and Wildlife Service and adopted by BPA as a habitat equivalency accounting system. Nine wildlife species models were used to evaluate distinct cover type features and provide a measure of habitat quality. Models measure a wide range of life requisite variables for each species and monitor overall trends in vegetation community health and diversity. One product of HEP is an evaluation of habitat quality expressed in Habitat Units (HUs). This HU accounting system is used to determine the amount of credit BPA receives for mitigation lands. After construction of the four lower Snake River dams, a HEP loss assessment was conducted to determine how many Habitat Units were inundated behind the dams. Twelve target species were used in that evaluation: Canada goose, mallard, river otter, downy woodpecker, song sparrow, yellow warbler, marsh wren, western meadowlark, chukar, ring-necked pheasant, California quail, and mule deer. The U.S. Army Corp of

  15. Habitat Evaluation Procedures (HEP) Report : Rainwater Wildlife Area, 1998-2001 Technical Report.

    SciTech Connect (OSTI)

    Childs, Allen

    2004-01-01

    The 8,768 acre Rainwater Wildlife Area was acquired in September 1998 by the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) through an agreement with Bonneville Power Administration (BPA) to partially offset habitat losses associated with construction of the John Day and McNary hydroelectric facilities on the mainstem Columbia River. U.S. Fish and Wildlife Service (USFWS) Habitat Evaluation Procedures (HEP) were used to determine the number of habitat units credited to BPA for acquired lands. Upland and riparian forest, upland and riparian shrub, and grassland rover types are evaluated in this study. Targeted wildlife species include downy woodpecker (Picoides pubescens), black-capped chickadee (Parus atricopillus), blue grouse (Dendragapus obscurus), great blue heron (Ardea herodias), yellow warbler (Dendroica petechia), mink (Mustela vison), and Western meadowlark (Sturnella neglects). Habitat surveys were conducted in 1998 and 1999 in accordance with published HEP protocols and included 65,300, 594m{sup 2} plots, and 112 one-tenth-acre plots. Between 153.3 and 7,187.46 acres were evaluated for each target wildlife mitigation species. Derived habitat suitability indices were multiplied by corresponding cover-type acreages to determine the number of habitat units for each species. The total baseline habitat units credited to BPA for the Rainwater Wildlife Area and its seven target species is 5,185.3 habitat units. Factors limiting habitat suitability are related to the direct, indirect, and cumulative effects of past livestock grazing, road construction, and timber harvest which have simplified the structure, composition, and diversity of native plant communities. Alternatives for protecting and improving habitat suitability include exclusion of livestock grazing, road de-commissioning/obliteration, reforestation and thinning, control of competing and unwanted vegetation (including noxious weeds), reestablishing displaced or reduced native

  16. Cyclosporine A and palmitic acid treatment synergistically induce cytotoxicity in HepG2 cells

    SciTech Connect (OSTI)

    Luo, Yi Rana, Payal; Will, Yvonne

    2012-06-01

    Immunosuppressant cyclosporine A (CsA) treatment can cause severe side effects. Patients taking immunosuppressant after organ transplantation often display hyperlipidemia and obesity. Elevated levels of free fatty acids have been linked to the etiology of metabolic syndromes, nonalcoholic fatty liver and steatohepatitis. The contribution of free fatty acids to CsA-induced toxicity is not known. In this study we explored the effect of palmitic acid on CsA-induced toxicity in HepG2 cells. CsA by itself at therapeutic exposure levels did not induce detectible cytotoxicity in HepG2 cells. Co-treatment of palmitic acid and CsA resulted in a dose dependent increase in cytotoxicity, suggesting that fatty acid could sensitize cells to CsA-induced cytotoxicity at the therapeutic doses of CsA. A synergized induction of caspase-3/7 activity was also observed, indicating that apoptosis may contribute to the cytotoxicity. We demonstrated that CsA reduced cellular oxygen consumption which was further exacerbated by palmitic acid, implicating that impaired mitochondrial respiration might be an underlying mechanism for the enhanced toxicity. Inhibition of c-Jun N-terminal kinase (JNK) attenuated palmitic acid and CsA induced toxicity, suggesting that JNK activation plays an important role in mediating the enhanced palmitic acid/CsA-induced toxicity. Our data suggest that elevated FFA levels, especially saturated FFA such as palmitic acid, may be predisposing factors for CsA toxicity, and patients with underlying diseases that would elevate free fatty acids may be susceptible to CsA-induced toxicity. Furthermore, hyperlipidemia/obesity resulting from immunosuppressive therapy may aggravate CsA-induced toxicity and worsen the outcome in transplant patients. -- Highlights: ? Palmitic acid and cyclosporine (CsA) synergistically increased cytotoxicity. ? The impairment of mitochondrial functions may contribute to the enhanced toxicity. ? Inhibition of JNK activity attenuated palmitate

  17. Staff | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    About Staff High Energy Physics (HEP) HEP Home About Organization Chart .pdf file (106KB) Staff HEP Budget HEP Committees of Visitors Directions Jobs University Research & ...

  18. Directions | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Directions High Energy Physics (HEP) HEP Home About Organization Chart .pdf file (106KB) Staff HEP Budget HEP Committees of Visitors Directions Jobs University Research & National ...

  19. Eicosapentaenoic acid (EPA) induced apoptosis in HepG2 cells through ROSCa{sup 2+}JNK mitochondrial pathways

    SciTech Connect (OSTI)

    Zhang, Yuanyuan; Han, Lirong; Qi, Wentao; Cheng, Dai; Ma, Xiaolei; Hou, Lihua; Cao, Xiaohong; Wang, Chunling

    2015-01-24

    Highlights: EPA evoked ROS formation, [Ca{sup 2+}]{sub c} accumulation, the opening of MPTP and the phosphorylation of JNK. EPA-induced [Ca{sup 2+}]{sub c} elevation was depended on production of ROS. EPA-induced ROS generation, [Ca{sup 2+}]{sub c} increase, and JNK activated caused MPTP opening. The apoptosis induced by EPA was related to release of cytochrome C through the MPTP. EPA induced HepG2 cells apoptosis through ROSCa{sup 2+}JNK mitochondrial pathways. - Abstract: Eicosapentaenoic acid (EPA), a well-known dietary n?3 PUFAS, has been considered to inhibit proliferation of tumor cells. However, the molecular mechanism related to EPA-induced liver cancer cells apoptosis has not been reported. In this study, we investigated the effect of EPA on HepG2 cells proliferation and apoptosis mechanism through mitochondrial pathways. EPA inhibited proliferation of HepG2 cells in a dose-dependent manner and had no significant effect on the cell viability of humor normal liver L-02 cells. It was found that EPA initially evoked ROS formation, leading to [Ca{sup 2+}]{sub c} accumulation and the mitochondrial permeability transition pore (MPTP) opening; EPA-induced HepG2 cells apoptosis was inhibited by N-acetylcysteine (NAC, an inhibitor of ROS), 1,2-bis (2-aminophenoxy) ethane-N,N,N?,N?-tetraacetic acid (BAPTA-AM, a chelator of calcium) and CsA (inhibitor of MPTP). The relationship between ROS production, the increase of cytoplasmic Ca and MPTP opening was detected. It seems that ROS may act as an upstream regulator of EPA-induced [Ca{sup 2+}]{sub c} generation, moreover, generation of ROS, overload of mitochondrial [Ca{sup 2+}]{sub c}, and JNK activated cause the opening of MPTP. Western blotting results showed that EPA elevated the phosphorylation status of JNK, processes associated with the ROS generation. Simultaneously, the apoptosis induced by EPA was related to release of cytochrome C from mitochondria to cytoplasm through the MPTP and activation of

  20. OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle

    SciTech Connect (OSTI)

    Zhong, Wenbin; Zhou, You; Li, Jiwei; Mysore, Raghavendra; Luo, Wei; Li, Shiqian; Chang, Mau-Sun; Olkkonen, Vesa M.; Yan, Daoguang

    2014-04-01

    We earlier identified OSBP-related protein 8 (ORP8) as an endoplasmic reticulum/nuclear envelope oxysterol-binding protein implicated in cellular lipid homeostasis, migration, and organization of the microtubule cytoskeleton. Here, a yeast two-hybrid screen identified Homo sapiens sperm associated antigen 5 (SPAG5)/Astrin as interaction partner of ORP8. The putative interaction was further confirmed by pull-down and co-immunoprecipitation assays. ORP8 did not colocalize with kinetochore-associated SPAG5 in mitotic HepG2 or HuH7 cells, but overexpressed ORP8 was capable of recruiting SPAG5 onto endoplasmic reticulum membranes in interphase cells. In our experiments, 25-hydroxycholesterol (25OHC) retarded the HepG2 cell cycle, causing accumulation in G2/M phase; ORP8 overexpression resulted in the same phenotype. Importantly, ORP8 knock-down dramatically inhibited the oxysterol effect on HepG2 cell cycle, suggesting a mediating role of ORP8. Furthermore, knock-down of SPAG5 significantly reduced the effects of both ORP8 overexpression and 25OHC on the cell cycle, placing SPAG5 downstream of the two cell-cycle interfering factors. Taken together, the present results suggest that ORP8 may via SPAG5 mediate oxysterol interference of the HepG2 cell cycle. - Highlights: The oxysterol-binding protein ORP8 was found to interact with the mitotic regulator SPAG5/Astrin. Treatment of HepG2 cells with 25-hydroxycholesterol caused cell cycle retardation in G2/M. ORP8 overexpression caused a similar G2/M accumulation, and ORP8 knock-down reversed the 25-hydroxycholesterol effect. Reduction of cellular of SPAG5/Astrin reversed the cell cycle effects of both 25-hydroxycholesterol and ORP8 overexpression. Our results suggest that ORP8 mediates via SPAG5/Astrin the oxysterol interference of HepG2 cell cycle.

  1. Report of the 2005 Snowmass Top/QCD Working Group

    SciTech Connect (OSTI)

    Juste, A.; Kiyo, Y.; Petriello, F.; Teubner, T.; Agashe, K.; Batra, P.; Baur, U.; Berger, C.F.; Cembranos, J.A.R.; Gehrmann-De Ridder, A.; Gehrmann, T.; Glover, E.W.N.; Godfrey, S.; Hoang, A.; Perelstein, M.; Sullivan, Z.; Tait, T.; Zhu, S.; /Johns Hopkins U. /Princeton, Inst. Advanced Study /Syracuse U. /Argonne /SUNY, Buffalo /SLAC /UC, Irvine /Zurich, ETH /Zurich U. /Durham U., IPPP /Ottawa Carleton Inst. Phys. /Munich, Max Planck Inst. /Cornell U., CIHEP /Peking U.

    2006-01-17

    This report discusses several topics in both top quark physics and QCD at an International Linear Collider (ILC). Issues such as measurements at the t tbar threshold, including both theoretical and machine requirements, and the determination of electroweak top quark couplings are reviewed. New results concerning the potential of a 500 GeV e+e collider for measuring Wtb couplings and the top quark Yukawa coupling are presented. The status of higher order QCD corrections to jet production cross sections, heavy quark form factors, and longitudinal gauge boson scattering, needed for percent-level studies at the ILC, are reviewed. A new study of the measurement of the hadronic structure of the photon at a gamma gamma collider is presented. The effects on top quark properties from several models of new physics, including composite models, Little Higgs theories, and CPT violation, are studied.

  2. 2001 Snowmass Accelerator R & D report (Conference) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Authors: Chao, Alexander ; Davidson, Ronald ; Dragt, Alexander ; Dugan, Gerald ; Holtkamp, Norbert ; Joshi, Chan ; Roser, Thomas ; Ruth, Ronald ; Seeman, John ; Strait, Jim ...

  3. ILC Comes to Snowmass (Journal Article) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Report Number(s): SLAC-REPRINT-2005-160 Journal ID: ISSN 0304-288X; CECOA2; TRN: US0601282 DOE Contract Number: AC02-76SF00515 Resource Type: Journal Article Resource Relation: ...

  4. LRD-22, a novel dual dithiocarbamatic acid ester, inhibits Aurora-A kinase and induces apoptosis and cell cycle arrest in HepG2 cells

    SciTech Connect (OSTI)

    Wang, Huiling; Li, Ridong; Li, Li; Ge, Zemei; Zhou, Rouli; Li, Runtao

    2015-02-27

    In this study we investigated the antitumor activity of the novel dual dithiocarbamatic acid ester LRD-22 in vitro and in vivo. Several cancer cell lines were employed to determine the effect of LRD-22 on cell growth, and the MTT assay showed there was a significant decrease in viable tumor cell numbers in the presence of LRD-22, especially in the HepG2 cell line. Colony formation assay also showed LRD-22 strongly inhibits HepG2 cell growth. Evaluation of the mechanism involved showed that inhibitory effects of LRD-22 on cell growth are due to induction of apoptosis and G2/M arrest. LRD-22 inhibited Aurora-A phosphorylation at Thr{sub 288} and subsequently impaired p53 phosphorylation at Ser{sub 315} which was associated with the proteasome degradation pathway. Tumor suppressor protein p53 is stabilized by this mechanism and accumulates through inhibition of Aurora-A kinase activity via treatment with LRD-22. In vivo study of HepG2 xenograft in nude mice also shows LRD-22 suppresses tumor growth at a concentration of 5 mg/kg without animals suffering loss of body weight. In conclusion, our results demonstrate LRD-22 acts as an Aurora-A kinase inhibitor to induce apoptosis and inhibit proliferation in HepG2 cells, and should be considered as a promising targeting agent for HCC therapy. - Highlights: • LRD-22 significantly inhibits cancer cell growth, especially in the HepG2 cell line. • The inhibitory effect of LRD-22 is due to induction of apoptosis and cell cycle arrest. • LRD-22 inhibits Aurora-A phosphorylation which results in subsequent impairment of the p53 pathway. • LRD-22 suppresses tumor growth in xenograft mice without body weight loss.

  5. Nanoscale Science Research Centers (NSRCs) | U.S. DOE Office of Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (SC) Nanoscale Science Research Centers (NSRCs) User Facilities User Facilities Home User Facilities at a Glance All User Facilities ASCR User Facilities BES User Facilities X-Ray Light Sources Neutron Scattering Facilities Nanoscale Science Research Centers (NSRCs) BER User Facilities FES User Facilities HEP User Facilities NP User Facilities User Resources User Statistics Policies and Processes Frequently Asked Questions User Facility Science Highlights User Facility News Contact

  6. Internalisation and multiple phosphorylation of γ-Conglutin, the lupin seed glycaemia-lowering protein, in HepG2 cells

    SciTech Connect (OSTI)

    Capraro, Jessica; Magni, Chiara; Faoro, Franco; Maffi, Dario; Scarafoni, Alessio; Tedeschi, Gabriella; Maffioli, Elisa; Parolari, Anna; Manzoni, Cristina; Lovati, Maria Rosa; Duranti, Marcello

    2013-08-09

    Highlights: •A glycaemia-reducing lupin seed protein is internalized by HepG2 cells. •The protein accumulates in the cytosol in an intact form. •The internalized protein is multiply phosphorylated. -- Abstract: Lupin seed γ-Conglutin is a protein capable of reducing glycaemia in mammalians and increasing glucose uptake by model cells. This work investigated whether γ-Conglutin is internalised into the target cells and undergoes any covalent change during the process, as a first step to understanding its mechanism of action. To this purpose, γ-Conglutin-treated and untreated HepG2 cells were submitted to confocal and transmission electron microscopy. Immune-revelation of γ-Conglutin at various intervals revealed its accumulation inside the cytosol. In parallel, 2D-electrophoresis of the cell lysates and antibody reaction of the blotted maps showed the presence of the protein intact subunits inside the treated cells, whilest no trace of the protein was found in the control cells. However, γ-Conglutin-related spots with an unexpectedly low pI were also observed in the maps. These spots were excised, trypsin-treated and submitted to MS/MS spectrometric analysis. The presence of phosphorylated amino acids was detected. These findings, by showing that γ-Conglutin is internalised by HepG2 cells in an intact form and is modified by multiple phosphorylation, open the way to the understanding of the lupin γ-Conglutin insulin-mimetic activity.

  7. Research Techniques

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Techniques Research Techniques Print Coming Soon

  8. Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans

    SciTech Connect (OSTI)

    Atienzar, Franck A.; Novik, Eric I.; Gerets, Helga H.; Parekh, Amit; Delatour, Claude; Cardenas, Alvaro; MacDonald, James; Yarmush, Martin L.; Dhalluin, Stphane

    2014-02-15

    Drug Induced Liver Injury (DILI) is a major cause of attrition during early and late stage drug development. Consequently, there is a need to develop better in vitro primary hepatocyte models from different species for predicting hepatotoxicity in both animals and humans early in drug development. Dog is often chosen as the non-rodent species for toxicology studies. Unfortunately, dog in vitro models allowing long term cultures are not available. The objective of the present manuscript is to describe the development of a co-culture dog model for predicting hepatotoxic drugs in humans and to compare the predictivity of the canine model along with primary human hepatocytes and HepG2 cells. After rigorous optimization, the dog co-culture model displayed metabolic capacities that were maintained up to 2 weeks which indicates that such model could be also used for long term metabolism studies. Most of the human hepatotoxic drugs were detected with a sensitivity of approximately 80% (n = 40) for the three cellular models. Nevertheless, the specificity was low approximately 40% for the HepG2 cells and hepatocytes compared to 72.7% for the canine model (n = 11). Furthermore, the dog co-culture model showed a higher superiority for the classification of 5 pairs of close structural analogs with different DILI concerns in comparison to both human cellular models. Finally, the reproducibility of the canine system was also satisfactory with a coefficient of correlation of 75.2% (n = 14). Overall, the present manuscript indicates that the dog co-culture model may represent a relevant tool to perform chronic hepatotoxicity and metabolism studies. - Highlights: Importance of species differences in drug development. Relevance of dog co-culture model for metabolism and toxicology studies. Hepatotoxicity: higher predictivity of dog co-culture vs HepG2 and human hepatocytes.

  9. 2013 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    3 High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits ... Reports HEP Sponsored Workshops and Conferences Contact Information High Energy Physics ...

  10. Facility Ops | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    High Energy Physics (HEP) HEP Home About Research Facilities User Facilities Facility Ops Projects, Missions, and Status Science Highlights Benefits of HEP Funding Opportunities ...

  11. 2012-2008 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    2-2008 High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights ... Reports HEP Sponsored Workshops and Conferences Contact Information High Energy Physics ...

  12. LBNL Scientist Shares 2011 Physics Nobel Prize | U.S. DOE Office...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    LBNL Scientist Shares 2011 Physics Nobel Prize High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory ...

  13. Funding Opportunities | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Opportunities High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Closed Funding Opportunity Announcements (FOAs) ...

  14. News and Resources | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    News and Resources High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources ...

  15. 2013 | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3 High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Featured Content ...

  16. Universe in a (Blue) Bottle | U.S. DOE Office of Science (SC...

    Office of Science (SC) Website

    Universe in a (Blue) Bottle High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community ...

  17. 2014 | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    4 High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Featured Content ...

  18. Community Resources | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Resources High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Featured ...

  19. HEP Science Highlights

    Office of Science (SC) Website

    neutrinos and antineutrinos are the same particle, and to see if neutrinos respect a natural symmetry, the reversal of time, need to be carried out. The discovery also...

  20. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALCF Future Systems June 10, 2015 | Author(s): Tim Williams | Download File: ExascaleReqsHEPALCF3systems.pdf | pdf | 3.1 MB ASCR Facility Plans June 10, 2015 | Author(s): Sudip...

  1. hep.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HPC Requirements Workshop: Cosmic Microwave Background Data Simulation & Analysis Julian Borrill Computational Cosmology Center, Berkeley Lab & Space Sciences Laboratory, UC Berkeley Overview * 3 NERSC repositories - mp107: O(10) NSF/NASA/DOE/international suborbital experiments - planck: current ESA/NASA satellite mission (with DOE IAA) - cmbpol: proposed NASA satellite mission * O(100) users, 4 projects (Planck, EBEX, PolarBear, QUIET), 2 modules (cmb, planck) * LBNL/UC Berkeley,

  2. Experimental High Energy Physics Research: Direct Detection of Dark Matter

    SciTech Connect (OSTI)

    Witherell, Michael S.

    2014-10-02

    The grant supported research on an experimental search for evidence of dark matter interactions with normal matter. The PI carried out the research as a member of the LUX and LZ collaborations. The LUX research team collected a first data set with the LUX experiment, a large liquid xenon detector installed in the Sanford Underground Research Facility (SURF). The first results were published in Physical Review Letters on March 4, 2014. The journal Nature named the LUX result a scientific highlight of the year for 2013. In addition, the LZ collaboration submitted the full proposal for the Lux Zeplin experiment, which has since been approved by DOE-HEP as a second-generation dark matter experiment. Witherell is the Level 2 manager for the Outer Detector System on the LUX-Zeplin experiment.

  3. Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit

    SciTech Connect (OSTI)

    Boylan, Joan M.; Salomon, Arthur R.; Tantravahi, Umadevi; Gruppuso, Philip A.

    2015-07-15

    Protein phosphatase 6 (PP6) is a ubiquitous Ser/Thr phosphatase involved in an array of cellular processes. To assess the potential of PP6 as a therapeutic target in liver disorders, we attenuated expression of the PP6 catalytic subunit in HepG2 cells using lentiviral-transduced shRNA. Two PP6 knock-down (PP6KD) cell lines (90% reduction of PP6-C protein content) were studied in depth. Both proliferated at a rate similar to control cells. However, flow cytometry indicated G2/M cell cycle arrest that was accounted for by a shift of the cells from a diploid to tetraploid state. PP6KD cells did not show an increase in apoptosis, nor did they exhibit reduced viability in the presence of bleomycin or taxol. Gene expression analysis by microarray showed attenuated anti-inflammatory signaling. Genes associated with DNA replication were downregulated. Mass spectrometry-based phosphoproteomic analysis yielded 80 phosphopeptides representing 56 proteins that were significantly affected by a stable reduction in PP6-C. Proteins involved in DNA replication, DNA damage repair and pre-mRNA splicing were overrepresented among these. PP6KD cells showed intact mTOR signaling. Our studies demonstrated involvement of PP6 in a diverse set of biological pathways and an adaptive response that may limit the effectiveness of targeting PP6 in liver disorders. - Highlights: • Lentiviral-transduced shRNA was used to generate a stable knockdown of PP6 in HepG2 cells. • Cells adapted to reduced PP6; cell proliferation was unaffected, and cell survival was normal. • However, PP6 knockdown was associated with a transition to a tetraploid state. • Genomic profiling showed downregulated anti-inflammatory signaling and DNA replication. • Phosphoproteomic profiling showed changes in proteins associated with DNA replication and repair.

  4. Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells

    SciTech Connect (OSTI)

    Chen, Yue; Zhang, Shunfen; Zhou, Tianyan; Huang, Chaoqun; McLaughlin, Alicia; Chen, Guangping

    2013-04-15

    Cytosolic sulfotransferases are one of the major families of phase II drug metabolizing enzymes. Sulfotransferase-catalyzed sulfonation regulates hormone activities, metabolizes drugs, detoxifies xenobiotics, and bioactivates carcinogens. Human dehydroepiandrosterone sulfotransferase (hSULT2A1) plays important biological roles by sulfating endogenous hydroxysteroids and exogenous xenobiotics. Genistein, mainly existing in soy food products, is a naturally occurring phytoestrogen with both chemopreventive and chemotherapeutic potential. Our previous studies have shown that genistein significantly induces hSULT2A1 in Hep G2 and Caco-2 cells. In this study, we investigated the roles of liver X receptor (LXRα) in the genistein induction of hSULT2A1. LXRs have been shown to induce expression of mouse Sult2a9 and hSULT2A1 gene. Our results demonstrate that LXRα mediates the genistein induction of hSULT2A1, supported by Western blot analysis results, hSULT2A1 promoter driven luciferase reporter gene assay results, and mRNA interference results. Chromatin immunoprecipitation (ChIP) assay results demonstrate that genistein increase the recruitment of hLXRα binding to the hSULT2A1 promoter. These results suggest that hLXRα plays an important role in the hSULT2A1 gene regulation. The biological functions of phytoestrogens may partially relate to their induction activity toward hydroxysteroid SULT. - Highlights: ► Liver X receptor α mediated genistein induction of hSULT2A1 in Hep G2 cells. ► LXRα and RXRα dimerization further activated this induction. ► Western blot results agreed well with luciferase reporter gene assay results. ► LXRs gene silencing significantly decreased hSULT2A1 expression. ► ChIP analysis suggested that genistein enhances hLXRα binding to the hSULT2A1 promoter.

  5. Plasmatic concentration of organochlorine lindane acts as metabolic disruptors in HepG2 liver cell line by inducing mitochondrial disorder

    SciTech Connect (OSTI)

    Benarbia, Mohammed el Amine; Macherel, David; Faure, Sbastien; Jacques, Caroline; Andriantsitohaina, Ramaroson; Malthiry, Yves

    2013-10-15

    Lindane (LD) is a persistent environmental pollutant that has been the subject of several toxicological studies. However, concentrations used in most of the reported studies were relatively higher than those found in the blood of the contaminated area residents and effects of low concentrations remain poorly investigated. Moreover, effects on cell metabolism and mitochondrial function of exposure to LD have received little attention. This study was designed to explore the effects of low concentrations of LD on cellular metabolism and mitochondrial function, using the hepatocarcinoma cell line HepG2. Cells were exposed to LD for 24, 48 and 72 h and different parameters linked with mitochondrial regulation and energy metabolism were analyzed. Despite having any impact on cellular viability, exposure to LD at plasmatic concentrations led to an increase of maximal respiratory capacity, complex I activity, intracellular ATP and NO release but decreased uncoupled respiration to ATP synthesis and medium lactate levels. In addition, LD exposure resulted in the upregulation of mitochondrial biogenesis genes. We suggest that, at plasmatic concentrations, LD acts as a metabolic disruptor through impaired mitochondrial function and regulation with an impact on cellular energetic metabolism. In addition, we propose that a cellular assay based on the analysis of mitochondria function, such as described here for LD, may be applicable for larger studies on the effects of low concentrations of xenobiotics, because of the exquisite sensitivity of this organelle. - Highlights: Our data clearly demonstrated in HepG2 cells that exposure at plasmatic low concentrations of LD were able to: Impair mitochondrial function Caused alteration on nucleo-mitochondrial cross-talk Increase nitric oxide release and protein nitration Impair cellular energetic metabolism and lipid accumulation.

  6. Transportation Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    transportation-research TRACC RESEARCH Computational Fluid Dynamics Computational Structural Mechanics Transportation Systems Modeling Transportation Research Current Research Overview The U.S. Department of Transportation (USDOT) has established its only high-performance computing and engineering analysis research facility at Argonne National Laboratory to provide applications support in key areas of applied research and development for the USDOT community. The Transportation Research and

  7. Research Gallery

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    Research Gallery Research Gallery Exhibits in this gallery capture Laboratory's leading-edge research in many areas of science and technology to help solve national problems...

  8. Inhibition of SH2-domain-containing inositol 5-phosphatase (SHIP2) ameliorates palmitate induced-apoptosis through regulating Akt/FOXO1 pathway and ROS production in HepG2 cells

    SciTech Connect (OSTI)

    Gorgani-Firuzjaee, Sattar; Adeli, Khosrow; Meshkani, Reza

    2015-08-21

    The serine–threonine kinase Akt regulates proliferation and survival by phosphorylating a network of protein substrates; however, the role of a negative regulator of the Akt pathway, the SH2-domain-containing inositol 5-phosphatase (SHIP2) in apoptosis of the hepatocytes, remains unknown. In the present study, we studied the molecular mechanisms linking SHIP2 expression to apoptosis using overexpression or suppression of SHIP2 gene in HepG2 cells exposed to palmitate (0.5 mM). Overexpression of the dominant negative mutant SHIP2 (SHIP2-DN) significantly reduced palmitate-induced apoptosis in HepG2 cells, as these cells had increased cell viability, decreased apoptotic cell death and reduced the activity of caspase-3, cytochrome c and poly (ADP-ribose) polymerase. Overexpression of the wild-type SHIP2 gene led to a massive apoptosis in HepG2 cells. The protection from palmitate-induced apoptosis by SHIP2 inhibition was accompanied by a decrease in the generation of reactive oxygen species (ROS). In addition, SHIP2 inhibition was accompanied by an increased Akt and FOXO-1 phosphorylation, whereas overexpression of the wild-type SHIP2 gene had the opposite effects. Taken together, these findings suggest that SHIP2 expression level is an important determinant of hepatic lipoapotosis and its inhibition can potentially be a target in treatment of hepatic lipoapoptosis in diabetic patients. - Highlights: • Lipoapoptosis is the major contributor to the development of NAFLD. • The PI3-K/Akt pathway regulates apoptosis in different cells. • The role of negative regulator of this pathway, SHIP2 in lipoapoptosis is unknown. • SHIP2 inhibition significantly reduces palmitate-induced apoptosis in HepG2 cells. • SHIP2 inhibition prevents palmitate induced-apoptosis by regulating Akt/FOXO1 pathway.

  9. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Submitter: Area of Research: Journal Reference: N/A

  10. A study of B(s)0 to J/psi phi in the D0 experiment and an example of HEP technology transfer

    SciTech Connect (OSTI)

    Bauer, Daniela Ursula

    2002-01-01

    After years of preparation, data taking with the upgraded D0 detector at the Tevatron proton-antiproton collider has begun. The large amount of data produced in a p{bar p}-collider requires sophisticated triggers to filter out the interesting events. Described in this thesis is the development of trigger software for the newly implemented Silicon Microstrip Tracker. D0 is a multi-purpose detector with a broad physics program. one area being studied at D0 is B mesons. An algorithm for reconstructing the B{sub s}{sup 0} and B{sub d}{sup 0} mesons and for measuring their lifetimes has been developed and is described in this thesis. The results suggest that an improvement of the current lifetime measurements can be achieved within the next two years. The reconstruction of a J/{psi} meson forms the basis for a wide range of b-physics. Data taken with the muon system during the commissioning period of the detector has been analyzed and a signal for the J/{psi} meson has been found. Systematic transfer of HEP technologies into other areas and their commercial exploitation plays an important role in the future of particle physics. An area of particular interest is DNA sequencing as shown by the recent completion of the sequencing of the human genome. The final part of this thesis details the development of a simulation for a high throughput sequencing device which is currently being developed at Imperial College.

  11. Research Highlights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Highlights Form Submit a New Research Highlight Sort Highlights Submitter Title Research Area Working Group Submission Date DOE Progress Reports Notable Research Findings for 2001-2006 Office of Science Abstracts Database Research Highlights Summaries Research Highlights Members of ARM's science team are major contributors to radiation and cloud research. ARM investigators publish about 150 refereed journal articles per year, and ARM data are used in many studies published by other scientific

  12. Research Projects

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    Current Research Projects Joint Los Alamos National LaboratoryUCSD Research Projects Collaborations between Los Alamos National Laboratory and the University of California at San...

  13. Research Highlight

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    Fog and Rain in the Amazon For original submission and image(s), see ARM Research Highlights http:www.arm.govsciencehighlights Research Highlight The diurnal and seasonal...

  14. Research Highlight

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    to Terrestrial Radiation Download a printable PDF Submitter: Mitchell, D. L., Desert Research Institute Area of Research: General Circulation and Single Column Models...

  15. Coherent Scattering Investigations at the Spallation Neutron Source: a Snowmass White Paper

    SciTech Connect (OSTI)

    Akimov, D. Moscow Engineering Physics Institute , Russia; Bernstein, A. Lawrence Livermore National Laboratory; BarbeauP.,; Barton, P. J. Lawrence Berkeley National Laboratory; Bolozdynya, A. Moscow Engineering Physics Institute , Russia; Cabrera-Palmer, B. Sandia National Laboratories; Cavanna, F. Yale University; Cianciolo, Vince ORNL; Collar, J. University of Chicago, Enrico Fermi Institute; Cooper, R. J. Indiana University; Dean, D. J. Oak Ridge National Laboratory; Efremenko, Yuri University of Tennessee and Oak Ridge National Laboratory; Etenko, A. Moscow Engineering Physics Institute , Russia; Fields, N. University of Chicago, Enrico Fermi Institute; Foxe, M. Pennsylvania State University, University Park, PA; Figueroa-Feliciano, E. Massachusetts Institute of Technology; Fomin, N. University of Tennessee, Knoxville; Gallmeier, F. Oak Ridge National Laboratory; Garishvili, I. University of Tennessee, Knoxville; Gerling, M. Sandia National Laboratories; Green, M. University of North Carolina, Chapel Hill; Greene, Geoffrey University of Tennessee, Knoxville; Hatzikoutelis, A. University of Tennessee, Knoxville; Henning, Reyco University of North Carolina, Chapel Hill; Hix, R. University of Tennessee and Oak Ridge National Laboratory; Hogan, D. University of California-Berkeley; Hornback, D. University of Tennessee and Oak Ridge National Laboratory; Jovanovic, I. Pennsylvania State University, University Park, PA; Hossbach, T. Pacific Northwest National Laboratory; Iverson, Erik B ORNL; Klein, S. R. Lawrence Berkeley National Laboratory; Khromov, A. Moscow Engineering Physics Institute , Russia; Link, J. Virginia Polytechnic Institute and State University; Louis, W. Los Alamos National Laboratory; Lu, W. Oak Ridge National Laboratory; Mauger, C. Los Alamos National Laboratory; Marleau, P. Sandia National Laboratories; Markoff, D. North Carolina Central University, Durham; Martin, R. D. University of South Dakota; Mueller, Paul Edward ORNL; Newby, J. Oak Ridge National Laboratory; Orrell, John L. Pacific Northwest National Laboratory; O'Shaughnessy, C. University of North Carolina, Chapel Hill; Penttila, Seppo Oak Ridge National Laboratory; Patton, K. North Carolina State University, Raleigh; Poon, A. W. Lawrence Berkeley National Laboratory; Radford, David C ORNL; Reyna, D. Sandia National Laboratories; Ray, H. University of Florida, Gainesville; Scholberg, K. Duke University, North Carolina; Sosnovtsev, V. Moscow Engineering Physics Institute , Russia; Tayloe, R. Indiana University; Vetter, K. Lawrence Berkeley National Laboratory; Virtue, C. Laurentian University, Canada; Wilkerson, J. University of North Carolina, Chapel Hill; Yoo, J. Fermi National Accelerator Laboratory; Yu, Chang-Hong ORNL

    2013-01-01

    The Spallation Neutron Source (SNS) at Oak Ridge National Laboratory, Tennessee, provides an intense flux of neutrinos in the few tens-of-MeV range, with a sharply-pulsed timing structure that is beneficial for background rejection. In this white paper, we describe how the SNS source can be used for a measurement of coherent elastic neutrino-nucleus scattering (CENNS), and the physics reach of different phases of such an experimental program (CSI: Coherent Scattering Investigations at the SNS).

  16. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SPartICus Submitter: Mishra, S., DOE - SunShot Initiative, AAAS S&T Policy Fellow Mitchell, D. L., Desert Research Institute Area of Research: General Circulation and Single...

  17. Research Projects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    LaboratoryNational Security Education Center Menu NSEC Educational Programs Los Alamos Dynamics Summer School Science of Signatures Advanced Studies Institute Judicial Science School SHM Data Sets and Software Research Projects Current Projects Past Projects Publications NSEC » Engineering Institute » Research Projects » Joint Los Alamos National Laboratory/UCSD research projects Past Research Projects Previous collaborations between Los Alamos National Laboratory and the University of

  18. Research Mission

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cells, fuels, gasification, innovative process technologies, methane hydrates, turbine thermal management, and unconventional gas and oil resources. Key research initiatives ...

  19. Research Areas

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Areas Our Vision National User Facilities Research Areas In Focus Global Solutions ⇒ Navigate Section Our Vision National User Facilities Research Areas In Focus Global Solutions Biosciences The Biosciences Area forges multidisciplinary teams to solve national challenges in energy, environment and health issues; and to advance the engineering of biological systems for sustainable manufacturing. Biosciences Area research is coordinated through three divisions and is enabled by Berkeley

  20. Current Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Current Research The U.S. Department of Transportation (USDOT) has established its only high-performance computing and engineering analysis research facility at Argonne National Laboratory to provide applications support in key areas of applied research and development for the USDOT community. The Transportation Research and Analysis Computing Center (TRACC) features a state-of-the-art massively parallel computer system, advanced scientific visualization capability, high-speed network

  1. Research Library

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Guides Video Tutorials Mobile Resources Alerts Bibliographic Management Scholarly Communication & Open Access Copyright Open Access ORCID Primo LANL Research Library: delivering essential knowledge services for national security sciences since 1947 About the Research Library Mission We deliver agile, responsive knowledge services, connecting people with information, technology and resources. Vision Essential knowledge services for national security sciences. The Research Library provides

  2. Methods Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Methods Research Methods being developed by MANTISSA Researchers Celeste: Bayesian modeling for astronomical images Randomized Linear Algebra for BioImaging Large-Scale PCA for Climate Efficient Graph Analytics for Genomics Unsupervised Learning for Neuroscience Deep Learning for Object Recognition Deep Learning for Daya Bay Unsupervised Learning in Neuroscience Last edited: 2016-07-18 16:52:3

  3. Postdoctoral Research Awards Annual Research Meeting: Joseph...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Joseph Mondloch Postdoctoral Research Awards Annual Research Meeting: Joseph Mondloch Postdoctoral Research Awards Annual Research Meeting: Joseph Mondloch poster presentation. ...

  4. COMP-1h.EPS

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Ballpoint pens Bandages Beach umbrellas Boats Cameras Candles Candies and gum Car battery cases Car enamel Cassettes Caulking CDscomputer disks Cellular phones Clothesline Coffee ...

  5. COMP-1h.EPS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tents Tires Toilet seats Tool boxes Tool racks Toothbrushes Toothpaste Transparent tape Trash bags TV cabinets Umbrellas Unbreakable dishes Upholstery Vaporizers Vinyl flooring...

  6. HEP-Req_SLAC.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laboratory Large Scale Computing and Storage Requirements for High Energy Physics NERSCASCRHEP Workshop, Washington D.C., November 12-13, 2009 NERSC Project * Project ...

  7. IntroHEP-compressed.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ASCR Facility Plans --- 1 --- June 1 0, 2 015 Projections on Moore's Law and other trends Figure c ourtesy o f Kunle O lukotun, Lance H ammond, H erb S u=er, a nd Burton S mith, 2 004 2 0 1 10 100 1000 10000 100000 1000000 10000000 1970 1975 1980 1985 1990 1995 2000 2005 2010 Transistors (Thousands) Frequency (MHz) Power (W) Cores 1.E+01 1.E+02 1.E+03 1.E+04 1.E+05 1.E+06 1.E+07 1/1/1992 1/1/1996 1/1/2000 1/1/2004 1/1/2008 1/1/2012 1/1/2016 1/1/2020 1/1/2024 Energy per Flop (pJ) Heavyweight

  8. Researchers - JCAP

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Researchers Who We Are JCAP Mission JCAP At A Glance Fact Sheets Organizational Chart Recent Science Technology Transfer Awards & Honors Senior Management Scientific Leadership Researchers Governance & Advisory Boards Operations & Administration Who we are Overview JCAP Mission JCAP At A Glance Fact Sheets Organizational Chart Our Achievements Recent Science Technology Transfer Awards & Honors Our People Senior Management Scientific Leadership Researchers Governance &

  9. Environmental Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Dist. Category UC-l 1, 13 DE@ 010764 Health & Environmental Research Summary of Accomplishments Prepared by Office of Energy Research /U.S. Department of Energy Washington, D.C. 20585 Reprinted April 1984 Published by Technical Information Center/U.S. Department of Energy The purpose of this brief narrative is to foster an awareness of a publicly funded health and environmental research program chartered nearly forty years ago, of its contributions toward the national goal of safe and

  10. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Back to Basics: Theoretical Studies on Storm Clouds and Implications for Modeling For original submission and image(s), see ARM Research Highlights http://www.arm.gov/science/highlights/ Research Highlight Storms associated with deep convection are a key component of weather and climate. For example, they produce a large share of precipitation that falls to the Earth's surface, and their anvil shields act as a thermal blanket on the planet. To understand the behavior of these storms, researchers

  11. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Radiative Forcing by Long-Lived Greenhouse Gases: Calculations with the AER Models Download a printable PDF Submitter: Iacono, M. J., Atmospheric & Environmental Research, Inc. Delamere, J. S., Tech-X Corporation Mlawer, E. J., Atmospheric & Environmental Research, Inc. Collins, W. D., Lawrence Berkeley National Laboratory Area of Research: General Circulation and Single Column Models/Parameterizations Working Group(s): Radiative Processes Journal Reference: Iacono, MJ, JS Delamere, EJ

  12. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climatology of Aerosol Optical Depth in North-Central Oklahoma: 1992-2008 Download a printable PDF Submitter: Michalsky, J. J., Cooperative Institute for Research in Environmental Sciences Area of Research: Aerosol Properties Working Group(s): Aerosol Life Cycle Journal Reference: Michalsky J, F Denn, C Flynn, G Hodges, P Kiedron, A Koontz, J Schlemmer, and SE Schwartz. 2010. "Climatology of aerosol optical depth in north-central Oklahoma: 1992-2008." Journal of Geophysical Research -

  13. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Partial Mechanistic Understanding of the North American Monsoon Download a printable PDF Submitter: Erfani, E., Desert Research Institute Area of Research: Atmospheric Thermodynamics and Vertical Structures Working Group(s): Cloud-Aerosol-Precipitation Interactions Journal Reference: Erfani E and DL Mitchell. 2014. "A partial mechanistic understanding of the North American monsoon." Journal of Geophysical Research - Atmospheres, 119(23), 10.1002/2014JD022038. a) Dependence of

  14. Research Highlights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Organizations » ADCLES » Chemistry » Research Highlights Research Highlights A publication highlights recent advances Contact Us Division Leader David Morris Deputy Division Leader Mark McCleskey (505) 667-4457 Division Office (505) 667-4457 Email Extraordinary work from Chemistry Division staff 2016 Santa Fe Community College receives equipment from Chemistry Division 7/28 Breaking the Bond 7/25 Students Receive DOE Research Awards 6/27 High-efficiency nanoelectrocatalysts 6/1 Physicist

  15. NETL Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Research One of the U.S. Department of Energy's (DOE) three strategic goals contained in the DOE's 2014-2018 Strategic Plan is to advance foundational science, innovate energy technologies, and inform data driven policies that enhance US economic growth and job creation, energy security, and environmental quality. DOE's National Energy Technology Laboratory contributes to this strategic goal through cutting-edge research and development focused on efficient energy use and clean energy

  16. PNNL: Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research at PNNL Research is our business With an unwavering focus on our missions, scientists and engineers at PNNL deliver science and technology. We conduct basic research that advances the frontiers of science. We translate discoveries into tools and technologies in science, energy, the environment and national security. For more than four decades, our experts have teamed with government, industry and academia to tackle some of the toughest problems facing our nation. The result: We're

  17. Research Approach

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Approach Research Approach NETL's onsite research approach is based on integrating simulation tools with targeted experimental validation at real-life conditions in the lab and in the field. Simulation tools increase confidence in designs, thereby reducing the risk associated with incorporating multiple innovative technologies, realizing scale-up, and predicting the behavior and properties of real materials. The scientific underpinnings encoded into these models also ensure that

  18. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Climate Research Facility located near Lamont, Oklahoma. Measurements from ARM Raman lidar and Doppler radar instruments were used to both initialize and evaluate the model. A...

  19. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in the Doppler spectra. Over the North Slope of Alaska, researchers used cloud radar Doppler velocity spectra, lidar backscattering coefficients and depolarization ratios, and...

  20. UNIRIB: Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of the University Radioactive Ion Beam (UNIRIB) consortium is to perform nuclear physics research, and provide training and education. UNIRIB member universities have gained...

  1. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Turner, D. D., National Oceanic and Atmospheric Administration Area of Research: Radiation Processes Working Group(s): Cloud Life Cycle Journal Reference: Paine SN, DD Turner, ...

  2. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    "Roobik" Is Part of the Answer, Not a Puzzle Submitter: Turner, D. D., National Oceanic and Atmospheric Administration Area of Research: Radiation Processes Working Group(s): ...

  3. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Submitter: Turner, D. D., National Oceanic and Atmospheric Administration Area of Research: Radiation Processes Working Group(s): Radiative Processes Journal Reference: Turner DD. ...

  4. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mlawer, E. J., Atmospheric & Environmental Research, Inc. Turner, D. D., National Oceanic ... Journal Reference: Cady-Pereira, K, M Shephard, E Mlawer, D Turner, S Clough, and T ...

  5. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Size Distributions with Help from Satellites Download a printable PDF Submitter: Mitchell, D. L., Desert Research Institute d'Entremont, R. P., Atmospheric and Environmental...

  6. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Download a printable PDF Submitter: Liu, Y., Brookhaven National Laboratory Zhang, M., ... By addressing the two plausible factors together, researchers at Brookhaven National ...

  7. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Spiraling Through a Storm PI Contact: Giangrande, S., Brookhaven National Laboratory Area of Research: Cloud Processes Working Group(s): Cloud Life Cycle Journal Reference: ...

  8. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Improving Entrainment Rate Parameterization Download a printable PDF Submitter: Liu, Y., Brookhaven National Laboratory Area of Research: Cloud Processes Working Group(s): Cloud ...

  9. Research | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the science behind them-for a future powered by clean energy. Subscribe Stay connected with the latest news and research breakthroughs from NREL. Sign up now Photo...

  10. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Hagos, S. M., Pacific Northwest National Laboratory Area of Research: Atmospheric Thermodynamics and Vertical Structures Working Group(s): Cloud Life Cycle Journal Reference: NA...

  11. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Submitter: Westwater, E. R., University of Colorado Area of Research: Atmospheric Thermodynamics and Vertical Structures Working Group(s): Cloud Properties Journal Reference:...

  12. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Liljegren, J. C., Argonne National Laboratory Area of Research: Atmospheric Thermodynamics and Vertical Structures Working Group(s): Cloud Properties, Radiative Processes...

  13. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Effects of Sea Spray on the Thermodynamics of the Hurricane Boundary Layer Download a printable PDF Submitter: Khain, A., The Hebrew University of Jerusalem Area of Research:...

  14. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fall Speeds of Cirrus Crystals Faster Than Expected PI Contact: Fridlind, A. M., NASA - Goddard Institute for Space Studies Area of Research: Cloud Processes Working Group(s): ...

  15. Research Library

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    For more resources see the Reports page. First try: IHS Standards Expert login more ... Library Catalog Los Alamos Authors Los Alamos Research Online Review & Approval System ...

  16. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a printable PDF Submitter: Marshak, A., NASA - Goddard Space Flight Center Area of Research: Radiation Processes Working Group(s): Cloud-Aerosol-Precipitation Interactions...

  17. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Influence of Dust Composition on Cloud Droplet Formation Download a printable PDF Submitter: Chuang, C., Lawrence Livermore National Laboratory Area of Research: Aerosol Properties...

  18. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Burning on the Prairies Submitter: Bhattacharya, A., Pacific Northwest National Laboratory Area of Research: Radiation Processes Working Group(s): Cloud-Aerosol-Precipitation...

  19. Research Proposals

    Broader source: Energy.gov [DOE]

    The EERE Postdoctoral Research Awards are intended to be an avenue for significant energy efficiency and renewable energy innovation. To enable the participants' creativity as they conduct their...

  20. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Long-Term Impacts of Aerosols on the Vertical Development of Clouds and Precipitation Download a printable PDF Submitter: Li, Z., University of Maryland Area of Research:...

  1. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Broadband Albedo Observations in the Southern Great Plains Submitter: Lamb, P. J., University of Oklahoma Area of Research: Aerosol Properties Working Group(s): Aerosol Journal...

  2. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    over the MJO Download a printable PDF Submitter: Del Genio, A. D., National Aeronautics and Space Administration Area of Research: Cloud DistributionsCharacterizations...

  3. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Get Organized Download a printable PDF Submitter: Del Genio, A. D., National Aeronautics and Space Administration Area of Research: Cloud Processes Working Group(s): Cloud...

  4. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Power in the Vertical: Using Wind Profiler Data to Study Precipitation Download a printable PDF Submitter: Kollias, P., Stony Brook University Area of Research: Radiation Processes ...

  5. Research Projects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Past Research Projects Composite-to-Steel Joint Integrity Monitoring and Assessment Collaboration between Los Alamos National Laboratory and the University of California at San ...

  6. Research Areas

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in diverse research areas such as cell biology, lithography, infrared microscopy, radiology, and x-ray tomography. Time-Resolved These techniques exploit the pulsed nature of...

  7. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ARM Sites Enable Assessment of Cluster Analysis for Identifying Cloud Regimes Submitter: Jakob, C., Monash University Area of Research: Cloud DistributionsCharacterizations...

  8. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nucleation Events Download a printable PDF Submitter: McMurry, P. ., University of Minnesota Area of Research: Aerosol Properties Working Group(s): Aerosol Life Cycle Journal ...

  9. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Differences Between Tropical and Trade-Wind Shallow Cumuli Download a printable PDF Submitter: Ghate, V. P., Argonne National Laboratory Area of Research: Vertical Velocity Working...

  10. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    to Lose Download a printable PDF Submitter: Laskin, A., Pacific Northwest National Laboratory Fast, J. ., Pacific Northwest National Laboratory Area of Research: Aerosol...

  11. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Area of Research: Cloud DistributionsCharacterizations Working Group(s): Cloud Life Cycle Journal Reference: Zhao Y, GG Mace, and JM Comstock. 2011. "The occurrence of particle ...

  12. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a printable PDF Submitter: Lin, Y., Geophysical Fluid Dynamics Laboratory Area of Research: General Circulation and Single Column ModelsParameterizations Working Group(s):...

  13. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and ARM Data Submitter: Somerville, R. C., Scripps Institution of Oceanography Area of Research: General Circulation and Single Column ModelsParameterizations Working Group(s):...

  14. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    PDF Submitter: McComiskey, A. C., National Oceanic and Atmospheric Administration Area of Research: Cloud-Aerosol-Precipitation Interactions Working Group(s): Aerosol Life Cycle,...

  15. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fog and Rain in the Amazon Download a printable PDF Submitter: Gentine, P., Columbia University Sobel, A., Columbia University Area of Research: Cloud-Aerosol-Precipitation...

  16. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Chamber Studies Uncover New Pathways for Atmospheric Aerosol Growth PI Contact: Smith, J., University of California, Irvine Area of Research: Aerosol Processes Working Group(s): ...

  17. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    They may appear innocuous, but researchers show that they contain an increasing number of particles released from human-caused pollution. Air currents sweep over Oklahoma City to ...

  18. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Northwest National Laboratory, researchers found that a significant increase in the amount of light scattered by the clouds was caused by the amount of pollution in the air. ...

  19. Research in High Energy Physics at Duke University

    SciTech Connect (OSTI)

    Kotwal, Ashutosh V.; Goshaw, Al; Kruse, Mark; Oh, Seog; Scholberg, Kate; Walter, Chris

    2013-07-29

    This is the Closeout Report for the research grant in experimental elementary particle physics, carried out by the Duke University High Energy Physics (HEP) group. We re- port on physics results and detector development carried out under this grant, focussing on the recent three-year grant period (2010 to 2013). The Duke HEP group consisted of seven faculty members, two senior scientists, #12;ve postdocs and eight graduate students. There were three thrusts of the research program. Measurements at the energy frontier at CDF and ATLAS were used to test aspects of elementary particle theory described by the Stan- dard Model (SM) and to search for new forces and particles beyond those contained within the SM. The neutrino sector was explored using data obtained from a large neutrino detector located in Japan, and R & D was conducted on new experiments to be built in the US. The measurements provided information about neutrino masses and the manner in which neutri- nos change species in particle beams. Two years ago we have started a new research program in rare processes based on the Mu2E experiment at Fermilab. This research is motivated by the search for the #22; ! e transition with unprecedented sensitivity, a transition forbidden in the standard model but allowed in supersymmetric and other models of new physics. The high energy research program used proton and antiproton colliding beams. The experiments were done at the Fermilab Tevatron (proton-antiproton collisions at a center of mass energy of 1.96 TeV) and at the CERN Large Hadron Collider (proton-proton collisions at 7-8 TeV). The neutrino program used data obtained from the Super-Kamiokande detec- tor. This water-#12;lled Cherenkov counter was used to detect and measure the properties of neutrinos produced in cosmic ray showers, and from neutrino beams produced from acceler- ators in Japan. The Mu2E experiment will use a special stopped muon beam to be built at Fermilab.

  20. Research in High Energy Physics at Duke University

    SciTech Connect (OSTI)

    Goshaw, Alfred; Kotwal, Ashutosh; Kruse, Mark; Oh, Seog; Scholberg, Kate; Walter, Chris

    2013-07-29

    This is the Closeout Report for the research grant in experimental elementary particle physics, carried out by the Duke University High Energy Physics (HEP) group. We re- port on physics results and detector development carried out under this grant, focussing on the recent three-year grant period (2010 to 2013). The Duke HEP group consisted of seven faculty members, two senior scientists, five postdocs and eight graduate students. There were three thrusts of the research program. Measurements at the energy frontier at CDF and ATLAS were used to test aspects of elementary particle theory described by the Stan- dard Model (SM) and to search for new forces and particles beyond those contained within the SM. The neutrino sector was explored using data obtained from a large neutrino detector located in Japan, and R & D was conducted on new experiments to be built in the US. The measurements provided information about neutrino masses and the manner in which neutri- nos change species in particle beams. Two years ago we have started a new research program in rare processes based on the Mu2E experiment at Fermilab. This research is motivated by the search for the #22;{mu} {yields} e transition with unprecedented sensitivity, a transition forbidden in the standard model but allowed in supersymmetric and other models of new physics. The high energy research program used proton and antiproton colliding beams. The experiments were done at the Fermilab Tevatron (proton-antiproton collisions at a center of mass energy of 1.96 TeV) and at the CERN Large Hadron Collider (proton-proton collisions at 7-8 TeV). The neutrino program used data obtained from the Super-Kamiokande detector. This water-filled Cherenkov counter was used to detect and measure the properties of neutrinos produced in cosmic ray showers, and from neutrino beams produced from acceler- ators in Japan. The Mu2E experiment will use a special stopped muon beam to be built at Fermilab.

  1. Research | Photosynthetic Antenna Research Center

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Research Mission Statement The objective of PARC is to understand the basic scientific principles that underpin the efficient functioning of natural photosynthetic antenna systems as a basis for design of biohybrid and bioinspired architectures for next-generation systems for solar-energy conversion. Scientific Themes Through basic scientific research, PARC seeks to understand the principles of light harvesting and energy funneling as applied to The PARC Vision Graphic three

  2. Bioprocessing research

    SciTech Connect (OSTI)

    Kaufman, E.N.

    1996-06-01

    This section describes research and development activities performed for the Fossil Energy Bioprocessing Research Program. This program includes fundamental research for coal applications that investigates advanced reactor design for conversion of coal and coal liquids, the use of enzymes in pure organic media, and development of biological processes for the conversion of coal residuum. In addition, the program includes studies on advanced bioreactor systems for the treatment of gaseous substrates and the conversion to liquid fuels, removal of heteroatoms from heavy oils, renewable hydrogen production, remediation of oil containing soils. The program also includes natural gas and oil technology partnership support.

  3. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Observing Warm Clouds in 3D Using ARM Scanning Cloud Radars and a Novel Ensemble Method Download a printable PDF Submitter: Fielding, M. D., University of Reading Area of Research:...

  4. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Download a printable PDF Submitter: Albrecht, B. A., University of Miami Area of Research: Cloud Processes Working Group(s): Cloud Life Cycle Journal Reference: Albrecht B, M Fang, ...

  5. Research Projects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The primary objective of this research effort is to develop and prototype a novel unmanned ground vehicle (UGV), as illustrated in the figure, that could be used for unmanned ...

  6. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ARM Program Research Improves Longwave Radiative Transfer Models Submitter: Turner, D. D., ... resolution infrared radiance. D.D. Turner, D.C. Tobin, S.A. Clough, P.D. Brown, ...

  7. Research Highlight

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    in Climate Models: Results from TC4 and ISDAC Download a printable PDF Submitter: Mitchell, D. L., Desert Research Institute Mishra, S., DOE - SunShot Initiative, AAAS S&T...

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    Area of Research: Aerosol Processes Working Group(s): Aerosol Life Cycle Journal Reference: Kulkarni G, S China, S Liu, M Nandasiri, N Sharma, J Wilson, AC Aiken, D Chand, A ...

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    MAGIC Ship-based Observations Help Validate Satellite Microwave Liquid Water Path PI Contact: Painemal, D., NASA LaRC SSAI Minnis, P., NASA - Langley Research Center Area of ...

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    To Rain or Not to Rain...Aerosols May Be the Answer Download a printable PDF Submitter: Li, Z., University of Maryland Area of Research: Cloud-Aerosol-Precipitation Interactions...

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    Area of Research: Cloud DistributionsCharacterizations Working Group(s): Cloud Modeling Journal Reference: Naud, C, A Del Genio, GG Mace, S Benson, EE Clothiaux, and P Kollias. ...

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    Area of Research: Cloud DistributionsCharacterizations Working Group(s): Cloud Properties Journal Reference: Wang X, KN Liou, SS Ou, GG Mace, and M Deng. 2009. "Remote sensing of ...

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    Dependence of Entrainment in Shallow Cumulus Convection on Vertical Velocity and Distance to Cloud Edge PI Contact: Kuang, Z., Harvard University Area of Research: Cloud Processes Working Group(s): Cloud Life Cycle Journal Reference: Tian Y and Z Kuang. 2016. "Dependence of entrainment in shallow cumulus convection on vertical velocity and distance to cloud edge." Geophysical Research Letters, , doi:10.1002/2016GL069005. ONLINE. Percentage change in (a) vertical velocity, (b) distance

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    Three Dimensions Are Better Than Two, When It Comes to Representing Aerosols PI Contact: Ching, J., Pacific Northwest National Laboratory Area of Research: Aerosol Properties Working Group(s): Aerosol Life Cycle Journal Reference: Ching J, RA Zaveri, RC Easter, N Riemer, and JD Fast. 2016. "A three-dimensional sectional representation of aerosol mixing state for simulating optical properties and cloud condensation nuclei." Journal of Geophysical Research - Atmospheres, 121(10),

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    Research Projects Joint Los Alamos National Laboratory/UCSD Research Projects Collaborations between Los Alamos National Laboratory and the University of California at San Diego (UCSD) Jacobs School of Engineering Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI Director Michael Todd (858) 534-5951 Professional Staff Assistant Jutta Kayser (505) 663-5649 Email Administrative Assistant Stacy Baker (505) 663-5233 Email "Since 2003, LANL has funded numerous collaborative

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    Testing and Comparing the Modified Anomalous Diffraction Approximation Submitter: Mitchell, D. L., Desert Research Institute Area of Research: Cloud Distributions/Characterizations Working Group(s): Radiative Processes Journal Reference: Mitchell, D.L., A.J. Baran, W.P. Arnott, C. Schmitt, 2006: Testing and comparing the anomalous diffraction approximation. J. Atmos. Sci., 63, 2948-2962. Comparison of MADA and T-matrix with measured Qext. Regions without data were contaminated by water vapor or

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    Quantifying Error in the Radiative Forcing of the First Aerosol Indirect Effect Submitter: McComiskey, A. C., National Oceanic and Atmospheric Administration Area of Research: Aerosol Properties Working Group(s): Aerosol Journal Reference: Submitted to Geophysical Research Letters, 06-27-2007. Radiative forcing of aerosol indirect as function of CCN number density and LWP in units of W/m2 per 5% IE error. A survey of recently published works shows that values used to represent the magnitude of

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    Characterization of Atmospheric Aerosols Using MFRSR Measurements Download a printable PDF Submitter: Alexandrov, M. D., Columbia University Area of Research: Aerosol Properties Working Group(s): Aerosol Journal Reference: Alexandrov, MD, AA Lacis, BE Carlson, and B Cairns. 2007. "Characterization of atmospheric aerosols using MFRSR measurements." (Journal of Geophysical Research 113, DO8204. Sample spectral optical depths of atmospheric constituents in 300 - 900 nm spectral range:

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    Improving Convection Parameterization Using ARM Observations and NCAR Community Atmosphere Model Download a printable PDF Submitter: Zhang, G., University of California, San Diego Area of Research: General Circulation and Single Column Models/Parameterizations Working Group(s): Cloud Modeling Journal Reference: Li, G, and GJ Zhang. 2008. "Understanding biases in shortwave cloud radiative forcing in the National Center for Atmospheric Research Community Atmosphere Model (CAM3) during El

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    Wide Angle Imaging Lidar: Active Optical Sensor Technology for Ground-Based Probing of Dense Clouds Download a printable PDF Submitter: Davis, A. B., Jet Propulsion Laboratory Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud Properties Journal Reference: Davis, AB. 2008. "Multiple-scattering lidar from both sides of the clouds: Addressing internal structure." Journal of Geophysical Research 113, D14S10, doi:10.1029/2007JD009666. Figure 1. Lidar

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    Threshold Radar Reflectivity Separating Precipitating from Non-Precipitating Clouds Download a printable PDF Submitter: Liu, Y., Brookhaven National Laboratory Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud Properties Journal Reference: Liu, Y, B Geerts, PH Daum, R McGraw, and M Miller. 2008. "Threshold radar reflectivity for drizzling clouds." Geophysical Research Letters 35, L03807, doi:10.1029/2007GL031201. Figure 1 shows the comparison of the

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    Cloud-Radiation Effects on Sea Ice Loss Download a printable PDF Submitter: Stephens, G. L., Colorado State University Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud Properties Journal Reference: Kay, JE, T L'Ecuyer, A Gettelman, G Stephens, and C O'Dell. "The contribution of cloud and radiation anomalies to the 2007 Arctic sea ice extent minimum." To appear in Geophysical Research Letters. Clouds and downwelling radiation 2007-2006 differences (June

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    Minimal Shortwave Anomalous Absorption Found over ACRF Sites Download a printable PDF Submitter: Dong, X., University of Arizona Minnis, P., NASA - Langley Research Center Area of Research: Radiation Processes Working Group(s): Radiative Processes Journal Reference: Dong, X, BA Wielicki, B Xi, Y Hu, GG Mace, S Benson, F Rose, S Kato, T Charlock, and P Minnis. 2008. "Using observations of deep convective systems to constrain atmospheric column absorption of solar radiation in the optically

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    Small Ice Crystals on Ice Sedimentation Rates in Cirrus Clouds and GCM Simulations Download a printable PDF Submitter: Mitchell, D. L., Desert Research Institute Rasch, P., Pacific Northwest National Laboratory Ivanova, D., Embry-Riddle Aeronautical University McFarquhar, G., University of Illinois, Urbana Nousiainen, T. P., University of Helsinki Area of Research: General Circulation and Single Column Models/Parameterizations Working Group(s): Cloud Properties Journal Reference: Mitchell, DL, P

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    Arctic Aerosol Study Flies By Download a printable PDF Submitter: Schmid, B., Pacific Northwest National Laboratory Area of Research: Aerosol Properties Working Group(s): Aerosol Journal Reference: ARM Climate Research Facility Operations Update, April 30, 2008, Edition Preliminary screening and analysis of images from the time-resolved aerosol collector indicate particles laden with carbon and sulfur. These data were obtained on April 8, 2008. Image courtesy of Alexander Laskin, PNNL. Images

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    The Surprisingly Large Contribution of Small Marine Clouds to Cloud Fraction and Reflectance Download a printable PDF Submitter: Oreopoulos, L., NASA Feingold, G., NOAA - Earth System Research Laboratory Koren, I., Weizmann Institute of Science Remer, L., NASA - GSFC, Laboratory for Atmospheres Area of Research: Clouds with Low Optical [Water] Depths (CLOWD) Working Group(s): Cloud Properties Journal Reference: Koren, I, L Oreopoulos, G Feingold, LA Remer, and O Altaratz. 2008. "How small

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    Atmospheric Aerosol Measurements on Cloudy Days: a New Method Download a printable PDF Submitter: Kassianov, E., Pacific Northwest National Laboratory Ovchinnikov, M., Pacific Northwest National Laboratory Area of Research: Aerosol Properties Working Group(s): Aerosol Journal Reference: Kassianov, EI, and M Ovtchinnikov. 2008. "On reflectance ratios and aerosol optical depth retrieval in the presence of cumulus clouds." Geophysical Research Letters doi:10.1029/2008GL033231.

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    Detection and Retrieval of Cirrus Clouds in the Tropics from AIRS: Validation from ARM Data Submitter: Yue, Q., Jet Propulsion Laboratory/California Institute of Technology Liou, K., University of California, Los Angeles Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud Properties Journal Reference: Yue Q and KN Liou. 2009. "Cirrus cloud optical and microphysical properties determined from AIRS infrared spectra." Geophysical Research Letters, 36, L05810,

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    Thin Is In Download a printable PDF Submitter: Tomlinson, J., Pacific Northwest National Laboratory Long, C. N., NOAA Global Monitoring Division/CIRES Comstock, J. M., Pacific Northwest National Laboratory Ronfeld, D., Pacific Northwest National Laboratory Area of Research: Radiation Processes Working Group(s): Cloud Properties Journal Reference: N/A The Twin Otter takes off to test the onboard instruments for the RACORO field campaign that began in January 2009. Researchers are gathering data

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    The Influence of Parameterized Ice Habit on Simulated Mixed-Phase Arctic Clouds Download a printable PDF Submitter: Harrington, J. Y., Pennsylvania State University Avramov, A., Columbia University Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud Modeling Journal Reference: Avramov A and JY Harrington. 2010. "Influence of parameterized ice habit on simulated mixed phase Arctic clouds." Journal of Geophysical Research - Atmospheres, 115, D03205,

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    Clouds Brighten Up the Sky Near Them Download a printable PDF Submitter: Varnai, T., University of Maryland, Baltimore County/JCEST Marshak, A., NASA - Goddard Space Flight Center Area of Research: Radiation Processes Working Group(s): Radiative Processes Journal Reference: Varnai T and A Marshak. 2009. "MODIS observations of enhanced clear sky reflectance near clouds." Geophysical Research Letters, 36, L06807, doi:10.1029/2008GL037089. Figure 1. Illustration of clouds enhancing the

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    Comparison of Ground-Based Millimeter-Wave Observations During RHUBC I Submitter: Cimini, D., CETEMPS - Dipartimento di Fisica Westwater, E. R., University of Colorado Payne, V., Jet Propulsion Laboratory/California Institute of Technology Turner, D. D., National Oceanic and Atmospheric Administration Mlawer, E. J., Atmospheric & Environmental Research, Inc. Exner, M., Radiometrics Corporation Cadeddu, M. P., Argonne National Laboratory Area of Research: Radiation Processes Working Group(s):

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    New Method for Retrieving Cloud Heights from Satellite Data Download a printable PDF Submitter: Chang, F., Science Systems and Applications, Inc. Minnis, P., NASA - Langley Research Center Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud Properties Journal Reference: Chang F, P Minnis, B Lin, MM Khaiyer, R Palikonda, and DA Spangenberg. 2010. "A modified method for inferring cloud top height using GOES-12 imager 10.7- and 13.3-µm data." Journal of

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    Surface Summertime Radiative Forcing by Shallow Cumuli at the ARM SGP Download a printable PDF Submitter: Berg, L., Pacific Northwest National Laboratory Area of Research: Radiation Processes Working Group(s): Cloud Life Cycle Journal Reference: Berg LK, EI Kassianov, CN Long, and DL Mills. 2011. "Surface summertime radiative forcing by shallow cumuli at the ARM SGP." Journal of Geophysical Research - Atmospheres, 116, D01202, 10.1029/2010JD014593. Histogram of hourly average shortwave

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    Adoption of RRTMG in the NCAR CAM5 and CESM1 Global Climate Models Download a printable PDF Submitter: Iacono, M. J., Atmospheric & Environmental Research, Inc. Collins, W. D., Lawrence Berkeley National Laboratory Area of Research: General Circulation and Single Column Models/Parameterizations Working Group(s): Cloud-Aerosol-Precipitation Interactions Journal Reference: N/A Figure 1. Shortwave cloud forcing for three versions of the NCAR Community Atmosphere Model (CAM) with CERES

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    Cumuli Impact on Solar Radiation at Surface: Spectral Changes Download a printable PDF Submitter: Kassianov, E., Pacific Northwest National Laboratory Area of Research: Aerosol Properties Working Group(s): Aerosol Life Cycle, Cloud Life Cycle, Cloud-Aerosol-Precipitation Interactions Journal Reference: Kassianov E, J Barnard, LK Berg, CN Long, and C Flynn. 2011. "Shortwave spectral radiative forcing of cumulus clouds from surface observations." Geophysical Research Letters, 38, L07801,

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    Possible Impact of Homogeneous Freezing Nucleation on in Situ Measurements Download a printable PDF Submitter: Mitchell, D. L., Desert Research Institute Mishra, S., DOE - SunShot Initiative, AAAS S&T Policy Fellow Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud Life Cycle, Cloud-Aerosol-Precipitation Interactions Journal Reference: Mitchell DL, S Mishra, and RP Lawson. 2011. Cirrus Clouds and Climate Engineering: New Findings on Ice Nucleation and Theoretical

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    Ice Heating Up Cold Clouds Download a printable PDF Submitter: Ovchinnikov, M., Pacific Northwest National Laboratory Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud-Aerosol-Precipitation Interactions Journal Reference: Ovchinnikov M, A Korolev, and J Fan. 2011. "Effects of ice number concentration on dynamics of a shallow mixed-phase stratiform cloud." Journal of Geophysical Research - Atmospheres, 116, D00T06, doi:10.1029/2011JD015888. The mighty cloud

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    Putting the Pieces Together Download a printable PDF Submitter: Fan, J., Pacific Northwest National Laboratory Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud Life Cycle Journal Reference: Fan J, S Ghan, M Ovchinnikov, X Liu, P Rasch, and A Korolev. 2011. "Representation of arctic mixed-phase clouds and the Wegener-Bergeron-Findeisen process in climate models: Perspectives from a cloud-resolving study." Journal of Geophysical Research - Atmospheres, 116,

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    Development and Recent Evaluation of the MT_CKD Model of Continuum Absorption Download a printable PDF Submitter: Mlawer, E. J., Atmospheric & Environmental Research, Inc. Area of Research: Radiation Processes Working Group(s): Cloud Life Cycle Journal Reference: Mlawer EJ, VH Payne, J Moncet, JS Delamere, MJ Alvarado, and DD Tobin. 2012. "Development and recent evaluation of the MT_CKD model of continuum absorption." Philosophical Transactions of The Royal Society A, 370, doi:

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    Pollution + Storm Clouds = Warmer Atmosphere Download a printable PDF Submitter: Fan, J., Pacific Northwest National Laboratory Area of Research: Cloud-Aerosol-Precipitation Interactions Working Group(s): Cloud-Aerosol-Precipitation Interactions Journal Reference: Fan J, D Rosenfeld, Y Ding, L Leung, and Z Li. 2012. "Potential aerosol indirect effects on atmospheric circulation and radiative forcing through deep convection." Geophysical Research Letters, 39, L09806,

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    Aerosols Help Heat Up the Yangtze River Delta in China Download a printable PDF Submitter: Flynn, C. J., Pacific Northwest National Laboratory Area of Research: Aerosol Properties Working Group(s): Aerosol Life Cycle Journal Reference: Liu J, Z Li, Y Zheng, C Flynn, and M Cribb. 2012. "Seasonal variations of aerosol optical properties, vertical distribution and associated radiative effects in the Yangtze Delta region of China." Journal of Geophysical Research, 117, D00K38,

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    ARM Measurements Help to Evaluate Radiation Codes Used in Global Modeling Download a printable PDF Submitter: Oreopoulos, L., NASA Mlawer, E. J., Atmospheric & Environmental Research, Inc. Area of Research: Radiation Processes Working Group(s): Cloud Life Cycle Journal Reference: Oreopoulos L, E Mlawer, J Delamere, T Shippert, J Cole, B Fomin, M Iacono, Z Jin, J Li, J Manners, P Raisanen, F Rose, Y Zhang, MJ Wilson, and WB Rossow. 2012. "The Continual Intercomparison of Radiation Codes:

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    "Invisible" Giants in the Sky Download a printable PDF Submitter: Kassianov, E., Pacific Northwest National Laboratory Area of Research: Radiation Processes Working Group(s): Aerosol Life Cycle Journal Reference: Kassianov E, M Pekour, and J Barnard. 2012. "Aerosols in central California: Unexpectedly large contribution of coarse mode to aerosol radiative forcing." Geophysical Research Letters, 39, L20806, doi:10.1029/2012GL053469. Daily averaged values of (a, b) the direct

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    Lord of the Wings: Elevated Particles a Rising Star Download a printable PDF Submitter: Kassianov, E., Pacific Northwest National Laboratory Area of Research: Radiation Processes Working Group(s): Aerosol Life Cycle Journal Reference: Kassianov E, C Flynn, J Redemann, B Schmid, PB Russell, and A Sinyuk. 2012. "Initial assessment of the Spectrometer for Sky-Scanning, Sun-Tracking Atmospheric Research (4STAR)-based aerosol retrieval: Sensitivity study." Atmosphere, 3,

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    Quantifying the Magnitude of Anomalous Solar Absorption Submitter: Ackerman, T. P., University of Washington Area of Research: General Circulation and Single Column Models/Parameterizations Working Group(s): Cloud Modeling Journal Reference: N/A Figure 1 Spurred by a series of articles published in 1995 claiming solar absorption in cloudy atmospheres far exceeded model predictions, Atmospheric Radiation Measurement (ARM) Program researchers at the Southern Great Plains (SGP) site in Oklahoma

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    Chinese Researchers Report Reliable Method for Monitoring Soil Moisture Submitter: Bhattacharya, A., Pacific Northwest National Laboratory Area of Research: Surface Properties Working Group(s): Cloud Life Cycle Journal Reference: Sun L, R Sun, XW Li, SL Liang, and RH Zhang. 2012. "Monitoring surface soil moisture status based on remotely sensed surface temperature and vegetation index information." Agricultural and Forest Meteorology, 166, doi:10.1016/j.agrformet.2012.07.015. Shown

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    Evaluation of Cloud Properties in Major Reanalyses Download a printable PDF Submitter: Liu, Y., Brookhaven National Laboratory Wu, W., Brookhaven National Laboratory Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud Life Cycle Journal Reference: Wu W, YG Liu, and AK Betts. 2012. "Observationally based evaluation of NWP reanalyses in modeling cloud properties over the Southern Great Plains." Journal of Geophysical Research - Atmospheres, 117, D12202,

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    A Decade and Counting Download a printable PDF Submitter: Long, C. N., NOAA Global Monitoring Division/CIRES Area of Research: Radiation Processes Working Group(s): Cloud-Aerosol-Precipitation Interactions Journal Reference: Long CN, SA McFarlane, A Del Genio, P Minnis, TP Ackerman, J Mather, J Comstock, GG Mace, M Jensen, and C Jakob. 2013. "ARM research in the equatorial western Pacific - a decade and counting." Bulletin of the American Meteorological Society, 94(5),

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    Field Campaign Resource Allocation Using Statistical Decision Analysis Download a printable PDF Submitter: Hanlon, C., Pennsylvania State University Area of Research: Cloud Processes Working Group(s): Cloud Life Cycle Journal Reference: Hanlon CJ, JB Stefik, AA Small, J Verlinde, and GS Young. 2013. "Statistical decision analysis for flight decision support: The SPartICus campaign." Journal of Geophysical Research - Atmospheres, , . ACCEPTED. In many atmospheric science field

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    The Brass Ring of Climate Modeling Download a printable PDF Submitter: Ghan, S. J., Pacific Northwest National Laboratory Area of Research: Aerosol Processes Working Group(s): Cloud-Aerosol-Precipitation Interactions Journal Reference: Ghan SJ, SJ Smith, M Wang, K Zhang, K Pringle, K Carslaw, J Pierce, S Bauer, and P Adams. 2013. "A simple model of global aerosol indirect effects." Journal of Geophysical Research - Atmospheres, 118, 1-20. The simple model of aerosol effects on clouds

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    Twenty Years Serving Climate Science Download a printable PDF Submitter: Mather, J. H., Pacific Northwest National Laboratory Area of Research: Cloud Processes Working Group(s): Aerosol Life Cycle, Cloud Life Cycle, Cloud-Aerosol-Precipitation Interactions Journal Reference: Mather JH and JW Voyles. 2013. "The ARM Climate Research Facility: a review of structure and capabilities." Bulletin of the American Meteorological Society, 94(3), doi:10.1175/BAMS-D-11-00218.1. A scanning ARM

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    CCN and Vertical Velocity Influences Submitter: Hudson, J. G., Desert Research Institute Area of Research: Cloud-Aerosol-Precipitation Interactions Working Group(s): Cloud-Aerosol-Precipitation Interactions Journal Reference: Hudson JG and S Noble. 2013. "CCN and vertical velocity influences on droplet concentrations and supersaturations in clean and polluted stratus clouds." Journal of the Atmospheric Sciences, 71(1), 10.1175/JAS-D-13-086.1. Figure 1. Effective cloud supersaturation

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    Hemispherical Simulations Show Impact of Aerosols on Cloud Reflectivity Submitter: Rotstayn, L., Commonwealth Scientific and Industrial Research Organization Area of Research: Aerosol Properties Working Group(s): Aerosol Journal Reference: Rotstayn, L., and Y. Liu, Sensitivity of the First Indirect Aerosol Effect to an Increase in Cloud Droplet Spectral Dispersion with Droplet Number Concentration, Journal of Climate: Vol. 16, No. 21, pp.3476-3481, May 2003. Figure 1. Measurements of the

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    Digging Into Climate Models' Needs with SPADE Download a printable PDF Submitter: Gustafson, W. I., Pacific Northwest National Laboratory Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud Life Cycle Journal Reference: Gustafson WI, PL Ma, H Xiao, B Singh, PJ Rasch, and JD Fast. 2013. "The separate physics and dynamics experiment (SPADE) framework for determining resolution awareness: A case study of microphysics." Journal of Geophysical Research -

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    Invisible Giants in the Sky Download a printable PDF Submitter: Kassianov, E., Pacific Northwest National Laboratory Area of Research: Cloud-Aerosol-Precipitation Interactions Working Group(s): Cloud-Aerosol-Precipitation Interactions Journal Reference: Kassianov E, M Pekour, and J Barnard. 2012. "Aerosols in central California: Unexpectedly large contribution of coarse mode to aerosol radiative forcing." Geophysical Research Letters, 39, L20806, doi:10.1029/2012GL053469. Photo

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    Nailing Down Ice in a Cloud Model Download a printable PDF Submitter: Comstock, J. M., Pacific Northwest National Laboratory Area of Research: Cloud Processes Working Group(s): Cloud Life Cycle Journal Reference: Comstock JM, A Protat, SA McFarlane, J Delanoë, and M Deng. 2013. "Assessment of uncertainty in cloud radiative effects and heating rates through retrieval algorithm differences: Analysis using 3 Years of ARM data at Darwin, Australia." Journal of Geophysical Research -

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    The Overambitious Other Carbon Submitter: Church, J., Pacific Northwest National Laboratory Area of Research: Aerosol Properties Working Group(s): Aerosol Life Cycle Journal Reference: Song C, M Gyawali, RA Zaveri, JE Shilling, and WP Arnott. 2013. "Light absorption by secondary organic aerosol from α-pinene: Effects of oxidants, seed aerosol acidity, and relative humidity." Journal of Geophysical Research - Atmospheres, 118, doi:10.1002/jgrd.50767. Time-dependent Mass Absorption

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    Observational Analysis of Land-Atmosphere Coupling for Climate Model Evaluation Download a printable PDF Submitter: Phillips, T. J., Lawrence Livermore National Laboratory Klein, S., Lawrence Livermore National Laboratory Area of Research: Surface Properties Working Group(s): Cloud Life Cycle Journal Reference: Phillips TJ and SA Klein. 2014. "Land-atmosphere coupling manifested in warm-season observations on the U.S. southern great plains." Journal of Geophysical Research -

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    A Revealing Look Inside Northern Australian Wet Season Precipitation Download a printable PDF Submitter: Giangrande, S., Brookhaven National Laboratory Area of Research: Surface Properties Working Group(s): Cloud Life Cycle Journal Reference: Giangrande SE, M Bartholomew, M Pope, S Collis, and MP Jensen. 2014. "A Summary of Precipitation Characteristics from the 2006-2011 Northern Australian Wet Seasons as Revealed by ARM Disdrometer Research Facilities (Darwin, Australia)." Journal of

  1. Research Highlight

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    MBL Aerosol Properties and Their Impact on CCN at the Azores-AMF Site Download a printable PDF Submitter: Dong, X., University of Arizona Area of Research: Aerosol Properties Working Group(s): Cloud-Aerosol-Precipitation Interactions Journal Reference: Logan T, B Xi, and X Dong. 2014. "Aerosol properties and their influences on marine boundary layer cloud condensation nuclei at the ARM mobile facility over the Azores." Journal of Geophysical Research - Atmospheres, 119(8),

  2. Research Highlight

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    Accuracy of GFS and ECMWF Hurricane Sandy Track Forecasts Dependent on Cumulus Parameterization Download a printable PDF Submitter: Bassill, N. P., University of Utah Zipser, E., University of Utah Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud Life Cycle Journal Reference: Bassill NP. 2014. "Accuracy of early GFS and ECMWF Sandy (2012) track forecasts: Evidence for a dependence on cumulus parameterization." Geophysical Research Letters, ,

  3. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research Masters the Misunderstood Mixed-Phase Cloud Download a printable PDF Submitter: Ovchinnikov, M., Pacific Northwest National Laboratory Area of Research: Cloud-Aerosol-Precipitation Interactions Working Group(s): Cloud Life Cycle, Cloud-Aerosol-Precipitation Interactions Journal Reference: Ovchinnikov M, AS Ackerman, A Avramov, A Cheng, J Fan, AM Fridland, S Ghan, J Harrington, C Hoose, A Korolev, GM McFarquhar, H Morrison, M Paukert, J Savre, BJ Shipway, MD Shupe, A Solomon, and K

  4. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Checking Up on Tropical Sunlight Download a printable PDF Submitter: Riihimaki, L., Pacific Northwest National Laboratory Long, C. N., NOAA Global Monitoring Division/CIRES Area of Research: Radiation Processes Working Group(s): Cloud Life Cycle Journal Reference: Riihimaki LD and CN Long. 2014. "Spatial variability of surface irradiance measurements at the Manus ARM site." Journal of Geophysical Research - Atmospheres, 119(9), 5475-5491. ACCEPTED. The radiometer system used at the

  5. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Gas-Phase Dry Deposition as a Major Removal Mechanism for Secondary Organic Aerosols (SOA) Download a printable PDF Submitter: Hodzic, A., NCAR Area of Research: Aerosol Properties Working Group(s): Aerosol Life Cycle Journal Reference: Hodzic A, B Aumont, C Knote, J Lee-Taylor, S Madronich, and G Tyndall. 2014. "Volatility dependence of Henry's law constants of condensable organics: Application to estimate depositional loss of secondary organic aerosols." Geophysical Research Letters,

  6. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Interactions Between Cumulus Convection and Its Environment as Revealed by MC3E Download a printable PDF Submitter: Xie, S., Lawrence Livermore National Laboratory Area of Research: Atmospheric Thermodynamics and Vertical Structures Working Group(s): Cloud Life Cycle Journal Reference: Xie S, Y Zhang, SE Giangrande, MP Jensen, R McCoy, and M Zhang. 2014. "Interactions between cumulus convection and its environment as revealed by the MC3E sounding array." Journal of Geophysical Research

  7. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Comparison of Vertical Velocities in Cirrus Derived from Aircraft and Ground-based Radar Download a printable PDF Submitter: Muhlbauer, A., University of Washington Kalesse, H., Leibniz Institute for Tropospheric Research Area of Research: Vertical Velocity Working Group(s): Cloud Life Cycle Journal Reference: Muhlbauer A, H Kalesse, and P Kollias. 2014. "Vertical velocities and turbulence in midlatitude anvil cirrus: A comparison between in situ aircraft measurements and ground-based

  8. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Quantifying the Importance of Cold Pool Mechanisms for Convection Triggering Download a printable PDF Submitter: Kuang, Z., Harvard University Area of Research: Cloud Processes Working Group(s): Cloud Life Cycle Journal Reference: Torri G, Z Kuang, and Y Tian. 2015. "Mechanisms for convection triggering by cold pools." Geophysical Research Letters, , . ACCEPTED. Horizontal sections of (left) potential temperature and (right) water vapor specific humidity at 25 m from the model surface.

  9. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Observed Relations Between Snowfall Microphysics and Triple-Frequency Radar Observations Download a printable PDF Submitter: Kneifel, S., McGill University Area of Research: Cloud Processes Working Group(s): Cloud Life Cycle Journal Reference: Kneifel S, A von Lerber, J Tiira, D Moisseev, P Kollias, and J Leinonen. 2015. "Observed relations between snowfall microphysics and triple-frequency radar measurements." Journal of Geophysical Research - Atmospheres, 120(12),

  10. Research Highlight

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    How Well Are Shallow Convective Clouds Simulated in the CAM5 Model? Download a printable PDF Submitter: Chandra, A. S., University of Miami Area of Research: Cloud Distributions/Characterizations Working Group(s): Cloud Life Cycle Journal Reference: Chandra AS, C Zhang, SA Klein, and H Ma. 2015. "Low-cloud characteristics over the tropical western Pacific from ARM observations and CAM5 simulations." Journal of Geophysical Research - Atmospheres, 120, 52402, doi:10.1002/2015JD02.