National Library of Energy BETA

Sample records for hep medicine homeland

  1. Medicine | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Medicine High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Medicine Homeland Security Industry Computing Sciences Workforce Development A Growing List Accelerators for Americas Future External link Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More

  2. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Presentations HEP Exascale Review Presentations Sort by: Default | Name | Date (low-high) | Date (high-low) | Source | Category HEP Requirements Review June 10, 2015 | Author(s): Barbara Helland, DOE ASCR | Download File: RequirementsreviewsHellandV3150610.pdf | pdf | 2.1 MB Opening Remarks June 10, 2015 | Author(s): Rob Roser, Salman Habib, Richard Gerber | Download File: HEP-ASCR-Exascale-opening-remarkssh.pdf | pdf | 187 KB P5 Science Drivers: Accelerator Experiments June 10, 2015 |

  3. HEP_Exaflop_brower

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Requirements Reviews: High Energy Physics Rich Brower (SciDAC software co-directorCUDA fellow) ... Lattice Field Theory has Come of Age HEP Need For Precision * Fundamental ...

  4. Homeland Security and Defense Applications

    SciTech Connect (OSTI)

    2014-11-06

    Homeland Security and Defense Applications personnel are the best in the world at detecting and locating dirty bombs, loose nukes, and other radiological sources. The site trains the Nation's emergency responders, who would be among the first to confront a radiological or nuclear emergency. Homeland Security and Defense Applications highly training personnel, characterize the threat environment, produce specialized radiological nuclear detection equipment, train personnel on the equipment and its uses, test and evaluate the equipment, and develop different kinds of high-tech equipment to defeat terrorists. In New York City for example, NNSS scientists assisted in characterizing the radiological nuclear environment after 9/11, and produced specialized radiological nuclear equipment to assist local officials in their Homeland Security efforts.

  5. Homeland Security and Defense Applications

    ScienceCinema (OSTI)

    None

    2015-01-09

    Homeland Security and Defense Applications personnel are the best in the world at detecting and locating dirty bombs, loose nukes, and other radiological sources. The site trains the Nation's emergency responders, who would be among the first to confront a radiological or nuclear emergency. Homeland Security and Defense Applications highly training personnel, characterize the threat environment, produce specialized radiological nuclear detection equipment, train personnel on the equipment and its uses, test and evaluate the equipment, and develop different kinds of high-tech equipment to defeat terrorists. In New York City for example, NNSS scientists assisted in characterizing the radiological nuclear environment after 9/11, and produced specialized radiological nuclear equipment to assist local officials in their Homeland Security efforts.

  6. Homeland Renewable Energy LLC | Open Energy Information

    Open Energy Info (EERE)

    Homeland Renewable Energy LLC Jump to: navigation, search Name: Homeland Renewable Energy LLC Place: Langhorne, Pennsylvania Zip: 19047 Product: Holding company for Fibrowatt LLC...

  7. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | 2.1 MB Opening Remarks June 10, 2015 | Author(s): Rob Roser, Salman Habib, Richard Gerber | Download File: HEP-ASCR-Exascale-opening-remarkssh.pdf | pdf | 187 KB Traditional...

  8. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | 2.1 MB Opening Remarks June 10, 2015 | Author(s): Rob Roser, Salman Habib, Richard Gerber | Download File: HEP-ASCR-Exascale-opening-remarkssh.pdf | pdf | 187 KB P5 Science...

  9. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Requirements Review June 10, 2015 | Author(s): Barbara Helland, DOE ASCR | Download File: RequirementsreviewsHellandV3150610.pdf | pdf | 2.1 MB Opening Remarks June 10, 2015 | Author(s): Rob Roser, Salman Habib, Richard Gerber | Download File: HEP-ASCR-Exascale-opening-remarkssh.pdf | pdf | 187 KB Traditional HPC needs: particle accelerators June 10, 2015 | Author(s): Jean-Luc Vay | Download File: DOEExascaleReviewVay.pdf | pdf | 19 MB P5 Science Drivers: Theory June 10, 2015 | Author(s):

  10. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALCF Future Systems June 10, 2015 | Author(s): Tim Williams | Download File: ExascaleReqsHEPALCF3systems.pdf | pdf | 3.1 MB ASCR Facility Plans June 10, 2015 | Author(s): Sudip Dosanjh | Download File: ASCR-Facilities-IntroHEP.pdf | pdf | 12 MB Computational Cosmology June 10, 2015 | Author(s): Katrin Heitmann | Download File: cosmohepascrheitmann.pdf | pdf | 6.5 MB Data Movement in HEP June 10, 2015 | Author(s): Brian Bockelman | Download File: Exascale-Data-Movement.pdf | pdf | 311 KB ESnet

  11. HEP-NERSCWorkshop.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP/NERSC Requirements Gathering Workshop Yukiko Sekine Program Manager, Facilities Division Advanced Scientific Computing Research Office of Science, DOE November 12 & 13, 2009 Advanced Scientific Computing Research Topics for Discussion * Current approaches to NERSC requirements gathering * Benefits of SC/HQ-centric requirements gathering for NERSC resources in the context of Programmatic mission needs * 2009 NERSC requirements gathering workshop schedule * An example outcome from

  12. HEP-Tsung.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    F. S. Tsung, HEP Workshop Project Summary -- Simulations of Plasma Based Accelerator Experiments Around the World. UCLA/IST is making a strong effort to quickly deploy simulation modeling to experimental teams - Laboratory frame simulations of LWFA's in OSIRIS - Boosted frame simulations of LWFA's in OSIRIS - Laboratory frame simulations of LWFA/PWFA's in QuickPIC Plasma based accelerators can achieve accelerating gradients 1,000 x that of those created by conventional accelerators. Recently, 2

  13. HEP Budget | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Budget High Energy Physics (HEP) HEP Home About Organization Chart .pdf file (106KB) Staff HEP Budget HEP Committees of Visitors Directions Jobs University Research & National Labs ...

  14. HEP Computing | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Computing A number of computing resources are available for HEP employees and visitors. Problem Report or Service Request - Send email to the computing group and log it on the Problem Report Page. (Note: You need to be connected to the ANL network or to be running VPN to submit a problem report.) New Users or Visitors - Start here if you are new to Argonne HEP. Password Help Email Windows Desktops Laptops Linux Users HEP Division FAQs - Find answers for commonly requested information here.

  15. Amber_HEP-NERSC.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DOE HEP Program Perspective HEP/NERSC Workshop November 12, 2009 2 What is High Energy Physics? The High Energy Physics (HEP) program mission is to understand how the universe works at its most fundamental level. We do this by:  Discovering the most elementary constituents of matter and energy,  Probing the interactions between them,  And exploring the basic nature of space and time. 3 The Three Frontiers of HEP  At the Energy Frontier, powerful accelerators are used to create new

  16. NREL: Technology Deployment - Strengthening Homeland Security...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Strengthening Homeland Security through Sustainable Energy News Executive Order 13693 ... established at DHS. Under that purview, the Mission Sustainable Energy program was formed. ...

  17. Reimbursable Work for Department of Homeland Security

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-02-28

    To authorize a modified process for the acceptance, performance, and administration of work from the Department of Homeland Security (DHS) by Department of Energy (DOE) contractor and federally operated laboratories, sites, and other facilities.

  18. U.S. Homeland Security R&D Budgets

    SciTech Connect (OSTI)

    Halvorson, C S

    2009-03-30

    The FY09 budgets for homeland security research and development programs in the U.S. are summarized. Homeland security policy developments that can influence future efforts are discussed. Initial indications of the new administration direction on homeland security R&D are summarized. An overview of the Optics and Photonics in Global Homeland Security V conference is presented.

  19. HEP Committees of Visitors | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Committees of Visitors High Energy Physics (HEP) HEP Home About Organization Chart .pdf file (106KB) Staff HEP Budget HEP Committees of Visitors Directions Jobs University Research ...

  20. HEP at Work | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Conference Rooms Computing Environment, Safety & Health Committees Wiki SharePoint Indico Travel Form Career Opportunities Staff Directory About HEP at Work Career Opportunities Staff Directory Argonne National Laboratory High Energy Physics Research Facilities Capabilities Initiatives Publications News & Events HEP at Work Conference Rooms Computing Environment, Safety & Health Committees Wiki SharePoint Indico Travel Form HEP at Work This page contains links to resources and tools

  1. HEP/NP Requirements Review 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP/NP Requirements Review 2013 Science Engagement Move your data Programs & Workshops Science Requirements Reviews Network Requirements Reviews Documents and Background Materials FAQ for Case Study Authors BER Requirements Review 2015 ASCR Requirements Review 2015 Previous Reviews HEP/NP Requirements Review 2013 HEP Attendees 2013 FES Requirements Review 2014 BES Requirements Review 2014 Requirements Review Reports Case Studies Contact Us Technical Assistance: 1 800-33-ESnet (Inside US) 1

  2. NERSC/DOE HEP Requirements Workshop Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | DOE HEP Overview November 12, 2009 | Author(s): Amber Boehnlein | Workshop Logistics November 12, 2009 | Author(s): Harvey Wasserman | NERSC Role in High Energy Physics...

  3. HEP BPI QCI Testing Reminders

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    HEP BPI QCI Testing Reminders Field Exams: * The video camera i s not to video you, but to listen to us as proctors * Use your field guide - make sure you talk about or demonstrate each item fully * If something doesn't look "right" (manometer, combustion analyzer etc..) check settings and if needed start over - this way you don't m iss a step or t ake the wrong readings * Consult correct BPI standards and m ake recommendations based o charts & action tables * Read f ully the

  4. Before the Senate Homeland Security and Governmental Affairs Subcommittee

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    on Contracting Oversight | Department of Energy Homeland Security and Governmental Affairs Subcommittee on Contracting Oversight Before the Senate Homeland Security and Governmental Affairs Subcommittee on Contracting Oversight Before the Senate Homeland Security and Governmental Affairs Subcommittee on Contracting Oversight By: Ingrid Kolb, Director Office of Management Subject: Improving Federal Contract Auditing 02-01-2011 Final MA Testimony (16.97 KB) More Documents & Publications

  5. Hearing Before the House Homeland Security Subcommittee on Oversight and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Management Efficiency | Department of Energy Homeland Security Subcommittee on Oversight and Management Efficiency Hearing Before the House Homeland Security Subcommittee on Oversight and Management Efficiency 5-17-16_Patricia_Hoffman FT HHS (166.72 KB) More Documents & Publications Testimony of Patricia A. Hoffman, Assistant Secretary for Office of Electricity Delivery and Energy Reliability, before the House Homeland Security Committee May 17, 2016 Joint Electromagnetic Pulse

  6. Before the Senate Homeland Security and Governmental Affairs...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Before the Senate Homeland Security and Governmental Affairs Subcommittee on Contracting Oversight By: Ingrid Kolb, Director Office of Management Subject: Improving Federal ...

  7. Indiana Department of Homeland Security - NNPP Exercise | Department...

    Office of Environmental Management (EM)

    Indiana Department of Homeland Security - NNPP Exercise (1.68 MB) More Documents & Publications Kentucky National Guard Radiation Specialist Course DOE Office of Nuclear Energy ...

  8. Before Senate Committee on Homeland Security and Governmental...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    on Homeland Security and Governmental Affairs, United States Senate By: Michael C. Kane, Chief Human Capital Officer, U.S. Department of Energy Subject: Inspiring Students to...

  9. ORISE: California Homeland Security Exercise and Evaluation Program...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    California Homeland Security Exercise and Evaluation Program (HSEEP) Training The Oak Ridge Institute for Science and Education (ORISE) and the California Governor's Office of ...

  10. Preliminary Benchmarking and MCNP Simulation Results for Homeland...

    Office of Scientific and Technical Information (OSTI)

    Preliminary Benchmarking and MCNP Simulation Results for Homeland Security Citation ... Visit OSTI to utilize additional information resources in energy science and technology. A ...

  11. Reimbursable Work for the Department of Homeland Security

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-08-17

    The Order establishes DOE policies and procedures for the acceptance, performance, and administration of reimbursable work directly funded by the Department of Homeland Security.

  12. Preliminary Benchmarking and MCNP Simulation Results for Homeland...

    Office of Scientific and Technical Information (OSTI)

    Preliminary Benchmarking and MCNP Simulation Results for Homeland Security Citation Details In-Document Search Title: Preliminary Benchmarking and MCNP Simulation Results for ...

  13. Hearing Before the House Homeland Security Subcommittee on Oversight...

    Energy Savers [EERE]

    for Office of Electricity Delivery and Energy Reliability, before the House Homeland Security Committee May 17, 2016 Joint Electromagnetic Pulse Resilience Strategy ...

  14. HEP Staff Directory | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Employee Spotlights About HEP at Work Career Opportunities Staff Directory Argonne National Laboratory High Energy Physics Research Facilities Capabilities Initiatives Publications News & Events Staff Directory Employee Spotlights HEP Staff Directory Name Title E-mail Abelof, Gabriel Joint Appointment Adams, Carolyn Electronic Technician cadams@anl.gov Anderson, John T. Principal Electronics Engineer Anthony, Michael Electronics Assistant mtanthony@anl.gov Arbelaez, Chrystian Posada

  15. Medicine Lodge Intermediate Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Medicine Lodge

  16. Science and Technology Challenges for Homeland Security

    SciTech Connect (OSTI)

    Murray, C A

    2006-03-24

    Preventing and protecting against catastrophic terrorism is a complex and dynamic challenge. Small groups or individuals can use advanced technology to cause massive destruction, and the rapid pace of technology and ease of information dissemination continually gives terrorists new tools. A 100% defense is not possible. It's a numbers problem--there are simply too many possible targets to protect and too many potential attack scenarios and adversaries to defend against. However, science and technology (S&T) is a powerful force multiplier for defense. We must use S&T to get ahead of the game by making terrorist attacks more difficult to execute, more likely to be interdicted, and less devastating in terms of casualties, economic damage, or lasting disruption. Several S&T areas have potential to significantly enhance homeland security efforts with regard to detecting radiation, pathogens, explosives, and chemical signatures of weapons activities. All of these areas require interdisciplinary research and development (R&D), and many critically depend on advances in materials science. For example, the science of nuclear signatures lies at the core of efforts to develop enhanced radiation detection and nuclear attribution capabilities. Current radiation detectors require cryogenic cooling and are too bulky and expensive. Novel signatures of nuclear decay, new detector materials that provide high resolution at ambient temperatures, and new imaging detectors are needed. Such technologies will improve our ability to detect and locate small, distant, or moving sources and to discriminate threat materials from legitimate sources. A more complete understanding of isotopic ratios via secondary ion mass spectrometry (SIMS), NanoSIMS, or yet-to-be-developed technologies is required to elucidate critical characteristics of nuclear materials (e.g., isotopics, age, reprocessing) in order to identify their source and route history. S&T challenges abound in the biodefense arena as

  17. Department of Homeland Security | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Department of Homeland Security NNSA Receives Excellence Award for Radiological Security Enhancements in Hawaii HONOLULU - At an official event this week, the City and County of Honolulu presented the Department of Energy's (DOE) National Nuclear Security Administration (NNSA) with the Homeland Security Excellence Award for DOE/NNSA's Office of Radiological Security's (ORS) efforts... NNSA to Participate in Aerial Radiation Training Exercise in Philadelphia, Pennsylvania (WASHINGTON, D.C.) - On

  18. Using HEP Technology to Fight Cancer

    SciTech Connect (OSTI)

    Le Du, Patrick

    2004-06-30

    Many engineering and physics HEP groups are now collaborating with medical doctors and biomedical scientists to develop new modern and 'state of the art' radiation instruments for cancer diagnostics and treatment. This presentation will review some of these studies, oriented towards the imaging fields for diagnostic (Positron Emission Tomography and Computed Tomography) and particle therapy for tumor treatment (from proton to light ions). I will try, using appropriate examples, to show what are the challenges and where the development of HEP concepts, tools and techniques can be used.

  19. HEP-v2-for-dist

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Case S tudy: C on.nuing S tudies o f P lasma B ased Accelerators ( mp113) * PI: W. B. Mori (UCLA) * Presenter: F. S. Tsung (UCLA) Users: W. An, A. Davidson, V. K. Decyk, (UCLA), J. Vieira, L. Silva (IST), W. Lu (UCLA/ Tsinghua) F. S. Tsung, HEP Workshop HEP R equirements: Con.nuing S tudies o f P lasma B ased A ccelerators ( mp113) (PI: W . B . M ori, P resenter: F . S . T sung) An alternate scheme to accelerate particles using plasmas is the Plasma WakeField Accelerator (PWFA) concept where a

  20. Proposed New Accelerator Design for Homeland Security X-Ray Applicatio...

    Office of Scientific and Technical Information (OSTI)

    Design for Homeland Security X-Ray Applications Citation Details In-Document Search Title: Proposed New Accelerator Design for Homeland Security X-Ray Applications In the ...

  1. Reimbursable Work for the Department of Homeland Security

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-08-17

    The Order establishes DOE policies and procedures for the acceptance, performance, and administration of reimbursable work directly funded by the Department of Homeland Security. Cancels DOE N 481.1 and DOE N 251.62. Admin Chg 1, dated 3-14-11.

  2. Reimbursable Work for the Department of Homeland Security

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-08-17

    The Order establishes DOE policies and procedures for the acceptance, performance, and administration of reimbursable work directly funded by the Department of Homeland Security. Admin Chg 2, dated 6-30-14, supersedes DOE O 484.1 Admin Chg 1. Certified 1-15-15

  3. HEP Science Network Requirements--Final Report

    SciTech Connect (OSTI)

    Bakken, Jon; Barczyk, Artur; Blatecky, Alan; Boehnlein, Amber; Carlson, Rich; Chekanov, Sergei; Cotter, Steve; Cottrell, Les; Crawford, Glen; Crawford, Matt; Dart, Eli; Dattoria, Vince; Ernst, Michael; Fisk, Ian; Gardner, Rob; Johnston, Bill; Kent, Steve; Lammel, Stephan; Loken, Stewart; Metzger, Joe; Mount, Richard; Ndousse-Fetter, Thomas; Newman, Harvey; Schopf, Jennifer; Sekine, Yukiko; Stone, Alan; Tierney, Brian; Tull, Craig; Zurawski, Jason

    2010-04-27

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the US Department of Energy Office of Science, the single largest supporter of basic research in the physical sciences in the United States. In support of the Office of Science programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In August 2009 ESnet and the Office of High Energy Physics (HEP), of the DOE Office of Science, organized a workshop to characterize the networking requirements of the programs funded by HEP. The International HEP community has been a leader in data intensive science from the beginning. HEP data sets have historically been the largest of all scientific data sets, and the communty of interest the most distributed. The HEP community was also the first to embrace Grid technologies. The requirements identified at the workshop are summarized below, and described in more detail in the case studies and the Findings section: (1) There will be more LHC Tier-3 sites than orginally thought, and likely more Tier-2 to Tier-2 traffic than was envisioned. It it not yet known what the impact of this will be on ESnet, but we will need to keep an eye on this traffic. (2) The LHC Tier-1 sites (BNL and FNAL) predict the need for 40-50 Gbps of data movement capacity in 2-5 years, and 100-200 Gbps in 5-10 years for HEP program related traffic. Other key HEP sites include LHC Tier-2 and Tier-3 sites, many of which are located at universities. To support the LHC, ESnet must continue its collaborations with university and international networks. (3) While in all cases the deployed 'raw' network bandwidth must exceed the user requirements in order to meet the data transfer and reliability requirements, network engineering for trans-Atlantic connectivity

  4. cet091110-hep_hpc.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Detector Simulation and Analysis Craig E. Tull, Ph.D. Staff Scientist/Group Leader Science Software Systems Group Computational Research Division Berkeley Lab Computing Sciences November 12, 2009 Rockville, MD HEP-HCG | Rockville | November 12, 2009 1. Detector Simulation and Analysis Overview Summarize the projects in your science area and their scientific objectives for the next 3-5 years * Current and past users of NERSC: - ATLAS - LHC accelerator at CERN, Geneva (PI: Ian Hinchliff) - Daya

  5. Future HEP Accelerators: The US Perspective

    SciTech Connect (OSTI)

    Bhat, Pushpalatha; Shiltsev, Vladimir

    2015-11-02

    Accelerator technology has advanced tremendously since the introduction of accelerators in the 1930s, and particle accelerators have become indispensable instruments in high energy physics (HEP) research to probe Nature at smaller and smaller distances. At present, accelerator facilities can be classified into Energy Frontier colliders that enable direct discoveries and studies of high mass scale particles and Intensity Frontier accelerators for exploration of extremely rare processes, usually at relatively low energies. The near term strategies of the global energy frontier particle physics community are centered on fully exploiting the physics potential of the Large Hadron Collider (LHC) at CERN through its high-luminosity upgrade (HL-LHC), while the intensity frontier HEP research is focused on studies of neutrinos at the MW-scale beam power accelerator facilities, such as Fermilab Main Injector with the planned PIP-II SRF linac project. A number of next generation accelerator facilities have been proposed and are currently under consideration for the medium- and long-term future programs of accelerator-based HEP research. In this paper, we briefly review the post-LHC energy frontier options, both for lepton and hadron colliders in various regions of the world, as well as possible future intensity frontier accelerator facilities.

  6. HEP Early Career Opportunities | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Early Career Opportunities High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Closed Funding Opportunity Announcements (FOAs) Closed Lab Announcements Award Search / Public Abstracts HEP Early Career Opportunities Review Policy / Proposal Guidelines / Reporting Requirements Additional Requirements and Guidance for Digital Data Management Acknowledgements of Federal Support Advisory Committees Community Resources Contact

  7. 2015-06-LATBauerdick-DOE-ASCR-HEP.key

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Lothar A. T. Bauerdick
 U.S. CMS Operations Program Manager June 10, 2015 HEP Facility Plans LATBauerdick I DOE SC Exascale Requirements Reviews -High Energy Physics 06/10/15 Distributed Facilities and Sharing of Resources * Experimental HEP mostly uses distributed high-throughput computing ✦ Before LHC most of the computing and storage capacity was at a 
 central experiment data center ✦ now most HEP experiments have adopted distributed computing, with global workflow, scheduling, and

  8. Detector systems for future HEP experiments (Journal Article...

    Office of Scientific and Technical Information (OSTI)

    SciTech Connect Search Results Journal Article: Detector systems for future HEP ... OSTI Identifier: 21182524 Resource Type: Journal Article Resource Relation: Journal Name: ...

  9. White Paper on DOE-HEP Accelerator Modeling Science Activities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    modeling science within the Department of Energy (DOE) Office of High Energy Physics (HEP) and (b) increasing the community-wide coordination and integration of code development. ...

  10. HEP Budget | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Budget Budget Budget Home About Budget by Program ASCR Budget BES Budget BER Budget FES Budget HEP Budget NP Budget WDTS Budget SLI Budget S&S Budget SCPD Budget GAO Audit Reports External Links Contact Information Budget U.S. Department of Energy SC-41/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3541 F: (301) 903-9524 More Information » Budget by Program HEP Budget Print Text Size: A A A FeedbackShare Page The following links contain HEP's budget

  11. Homeland Security and Emergency Management Coordination (HSEMC) Program |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration | (NNSA) Homeland Security and Emergency Management Coordination (HSEMC) Program NNSA ensures that capabilities are in place to respond to any NNSA and Department of Energy facility emergency. It is also the nation's premier responder to any nuclear or radiological incident within the United States or abroad and provides operational planning and training to counter both domestic and international nuclear terrorism. NNSA ensures that capabilities are

  12. Homeland Security Presidential Directive (HSPD)-12 | National Nuclear

    National Nuclear Security Administration (NNSA)

    Security Administration | (NNSA) Homeland Security Presidential Directive (HSPD)-12 HSPD-12 mandates a common identification standard for all Federal employees and contractors who have a need to access government facilities and information systems. The NNSA goal is to develop a common solution for effective and secure logical and physical access for longer than six months. Individuals who have a valid need to access NNSA-owned security areas, facilities and information systems will be issued

  13. Notices DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    4008 Federal Register / Vol. 80, No. 204 / Thursday, October 22, 2015 / Notices DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management Agency [Docket ID FEMA-2015-0006] Guidelines for Implementing Executive Order 11988, Floodplain Management, and Executive Order 13690, Establishing a Federal Flood Risk Management Standard and a Process for Further Soliciting and Considering Stakeholder Input AGENCY: Federal Emergency Management Agency, DHS. ACTION: Notice. SUMMARY: This notice serves to

  14. Unmanned and Unattended Response Capability for Homeland Defense

    SciTech Connect (OSTI)

    BENNETT, PHIL C.

    2002-11-01

    An analysis was conducted of the potential for unmanned and unattended robotic technologies for forward-based, immediate response capabilities that enables access and controlled task performance. The authors analyze high-impact response scenarios in conjunction with homeland security organizations, such as the NNSA Office of Emergency Response, the FBI, the National Guard, and the Army Technical Escort Unit, to cover a range of radiological, chemical and biological threats. They conducted an analysis of the potential of forward-based, unmanned and unattended robotic technologies to accelerate and enhance emergency and crisis response by Homeland Defense organizations. Response systems concepts were developed utilizing new technologies supported by existing emerging threats base technologies to meet the defined response scenarios. These systems will pre-position robotic and remote sensing capabilities stationed close to multiple sites for immediate action. Analysis of assembled systems included experimental activities to determine potential efficacy in the response scenarios, and iteration on systems concepts and remote sensing and robotic technologies, creating new immediate response capabilities for Homeland Defense.

  15. HEP Committees of Visitors | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEPAP Home HEP Committees of Visitors High Energy Physics Advisory Panel (HEPAP) HEPAP Home Meetings 2016 HEPAP Membership ChargesReports Charter .pdf file (44KB) HEP ...

  16. Active, Non-Intrusive Inspection Technologies for Homeland Defense

    SciTech Connect (OSTI)

    James L. Jones

    2003-06-01

    Active, non-intrusive inspection or interrogation technologies have been used for 100 years - with the primary focus being radiographic imaging. During the last 50 years, various active interrogation systems have been investigated and most have revealed many unique and interesting capabilities and advantages that have already benefited the general public. Unfortunately, except for medical and specific industrial applications, these unique capabilities have not been widely adopted, largely due to the complexity of the technology, the overconfident reliance on passive detection systems to handle most challenges, and the unrealistic public concerns regarding radiation safety issues for a given active inspection deployment. The unique homeland security challenges facing the United States today are inviting more "out-of-the-box" solutions and are demanding the effective technological solutions that only active interrogation systems can provide. While revolutionary new solutions are always desired, these technology advancements are rare, and when found, usually take a long time to fully understand and implement for a given application. What's becoming more evident is that focusing on under-developed, but well-understood, active inspection technologies can provide many of the needed "out-of-the-box" solutions. This paper presents a brief historical overview of active interrogation. It identifies some of the major homeland defense challenges being confronted and the commercial and research technologies presently available and being pursued. Finally, the paper addresses the role of the Idaho National Engineering and Environmental Laboratory and its partner, the Idaho Accelerator Center at Idaho State University, in promoting and developing active inspection technologies for homeland defense.

  17. Overview of accelerators with potential use in homeland security

    SciTech Connect (OSTI)

    Garnett, Robert W.

    2015-01-01

    Quite a broad range of accelerators have been applied to solving many of the challenging problems related to homeland security and defense. These accelerator systems range from relatively small, simple, and compact, to large and complex, based on the specific application requirements. They have been used or proposed as sources of primary and secondary probe beams for applications such as radiography and to induce specific reactions that are key signatures for detecting conventional explosives or fissile material. A brief overview and description of these accelerator systems, their specifications, and application will be presented. Some recent technology trends will also be discussed.

  18. Overview of accelerators with potential use in homeland security

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Garnett, Robert W.

    2015-01-01

    Quite a broad range of accelerators have been applied to solving many of the challenging problems related to homeland security and defense. These accelerator systems range from relatively small, simple, and compact, to large and complex, based on the specific application requirements. They have been used or proposed as sources of primary and secondary probe beams for applications such as radiography and to induce specific reactions that are key signatures for detecting conventional explosives or fissile material. A brief overview and description of these accelerator systems, their specifications, and application will be presented. Some recent technology trends will also bemore » discussed.« less

  19. DOE Order 484.1, Reimbursable Work for the Department of Homeland...

    Office of Environmental Management (EM)

    Order 484.1, Reimbursable Work for the Department of Homeland Security Change DOE Order 484.1, Reimbursable Work for the Department of Homeland Security Change The purpose of this ...

  20. HEP Collider HPC Use, Prospects and Wishes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Collider HPC Use, Prospects and Wishes Tom L eCompte High E nergy P hysics D ivision Argonne N a4onal L aboratory 2 Outline § Overview o f t he S cience § Overview o f H PC u se T oday § Some E xtrapola?ons t o t he F uture I a m a n L HC e xperimenter. T his t alk i s a rranged a round t hat experience - a t t he p resent ? me, w e a re t he o nly m ajor experimental H EP g roup u sing H PCs a t t his s cale. 3 Collider Physics for Non-Physicists § We c ollide p ar?cles t

  1. A Geospatial Integrated Problem Solving Environment for Homeland Security Applications

    SciTech Connect (OSTI)

    Koch, Daniel B

    2010-01-01

    Effective planning, response, and recovery (PRR) involving terrorist attacks or natural disasters come with a vast array of information needs. Much of the required information originates from disparate sources in widely differing formats. However, one common attribute the information often possesses is physical location. The organization and visualization of this information can be critical to the success of the PRR mission. Organizing information geospatially is often the most intuitive for the user. In the course of developing a field tool for the U.S. Department of Homeland Security (DHS) Office for Bombing Prevention, a geospatial integrated problem solving environment software framework was developed by Oak Ridge National Laboratory. This framework has proven useful as well in a number of other DHS, Department of Defense, and Department of Energy projects. An overview of the software architecture along with application examples are presented.

  2. FES BER HEP NP BES ASCR NERSC Science Highlights

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    detail. (Saye, LBNL, Science Advances) High Energy Physics Model confirms existence of an ... Brown-Dwarf Companion to Accre*ng White Dwarf HEP PI: E. Baron (Univ. of Oklahoma) ...

  3. West Foster Creek Expansion Project 2007 HEP Report.

    SciTech Connect (OSTI)

    Ashley, Paul R.

    2008-02-01

    During April and May 2007, the Columbia Basin Fish and Wildlife Authority's (CBFWA) Regional HEP Team (RHT) conducted baseline Habitat Evaluation Procedures (HEP) (USFWS 1980, 1980a) analyses on five parcels collectively designated the West Foster Creek Expansion Project (3,756.48 acres). The purpose of the HEP analyses was to document extant habitat conditions and to determine how many baseline/protection habitat units (HUs) to credit Bonneville Power Administration (BPA) for funding maintenance and enhancement activities on project lands as partial mitigation for habitat losses associated with construction of Grand Coulee and Chief Joseph Dams. HEP evaluation models included mule deer (Odocoileus hemionus), western meadowlark (Sturnella neglecta), sharp-tailed grouse, (Tympanuchus phasianellus), Bobcat (Lynx rufus), mink (Neovison vison), mallard (Anas platyrhynchos), and black-capped chickadee (Parus atricapillus). Combined 2007 baseline HEP results show that 4,946.44 habitat units were generated on 3,756.48 acres (1.32 HUs per acre). HEP results/habitat conditions were generally similar for like cover types at all sites. Unlike crediting of habitat units (HUs) on other WDFW owned lands, Bonneville Power Administration received full credit for HUs generated on these sites.

  4. Building global HEP systems on Kerberos

    SciTech Connect (OSTI)

    Crawford, Matt; /Fermilab

    2004-12-01

    As an underpinning of AFS and Windows 2000, and as a formally proven security protocol [1] in its own right, Kerberos is ubiquitous among HEP sites. Fermilab and users from other sites have taken advantage of this and built a diversity of distributed applications over Kerberos v5. We present several projects in which this security infrastructure has been leveraged to meet the requirements of geographically dispersed collaborations. These range from straightforward ''Kerberization'' of applications such as database and batch services, to quick tricks like simulating a user-authenticated web service with AFS and the ''file'': schema, to more complex systems. Examples of the latter include experiment control room operations and the Central Analysis Farm (CAF). We present several use cases and their security models, and examine how they attempt to address some of the outstanding problems of secure distributed computing: delegation of the least necessary privilege; establishment of trust between a user and a remote processing facility; credentials for long-queued or long-running processes, and automated processes running without any user's presence; security of remotely-stored credentials; and ability to scale to the numbers of sites, machines and users expected in the collaborations of the coming decade.

  5. DOE Order 484.1, Reimbursable Work for the Department of Homeland Security

    Office of Environmental Management (EM)

    Change | Department of Energy Order 484.1, Reimbursable Work for the Department of Homeland Security Change DOE Order 484.1, Reimbursable Work for the Department of Homeland Security Change The purpose of this Flash is to inform contracting personnel that the department issued an administrative change to DOE Order 484.1, Reimbursable Work for the Department of Homeland Security. The changes update organizational names and references. Attached is a summary of the change with the updated

  6. ORISE: U.S. Department of Homeland Security is seeking faculty...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    U.S. Department of Homeland Security is seeking faculty, graduate students and undergraduate students for summer 2016 research programs Deadlines to apply occur in December 2015...

  7. Before the House Subcommittee on Counterterrorism and Intelligence- Committee on Homeland Security

    Broader source: Energy.gov [DOE]

    Subject: Implications of Refinery Closures for U.S. Homeland Security and Critical Infrastructure Safety By: Howard Gruenspecht, Acting Administrator of the Energy Information Administration

  8. Shillapoo Wildlife Area 2007 Follow-up HEP Report.

    SciTech Connect (OSTI)

    Ashley, Paul R.

    2008-03-01

    In April and May 2007 the Regional HEP Team (RHT) conducted a follow-up HEP analysis on the Egger (612 acres) and Herzog (210 acres) parcels located at the north end of the Shillapoo Wildlife Area. The Egger and Herzog parcels have been managed with Bonneville Power Administration funds since acquired in 1998 and 2001 respectively. Slightly more than 936 habitat units (936.47) or 1.14 HUs per acre was generated as an outcome of the 2007 follow-up HEP surveys. Results included 1.65 black-capped chickadee HUs, 280.57 great blue heron HUs, 581.45 Canada goose HUs, 40 mallard HUs, and 32.80 mink HUs. Introduction A follow-up Habitat Evaluation Procedures (HEP) (USFWS 1980) analysis was conducted by the Columbia Basin Fish and Wildlife Authority's (CBFWA) Regional HEP Team (RHT) during April and May 2007 to document changes in habitat quality and to determine the number of habitat units (HUs) to credit Bonneville Power Administration (BPA) for providing operation and maintenance (O&M) funds since WDFW acquired the parcels. The 2007 follow-up HEP evaluation was limited to Shillapoo Wildlife Area (SWA) parcels purchased with Bonneville Power Administration funds. D. Budd (pers. comm.) reported WDFW purchased the 612 acre Egger Farms parcel on November 2, 1998 for $1,737,0001 and the 210 acre Herzog acquisition on June 21, 2001 for $500,000 with Memorandum of Agreement funds (BPA and WDFW 1996) as partial fulfillment of BPA's wildlife mitigation obligation for construction of Bonneville and John Day Dams (Rasmussen and Wright 1989). Anticipating the eventual acquisition of the Egger and Herzog properties, WDFW conducted HEP surveys on these lands in 1994 to determine the potential number of habitat units to be credited to BPA. As a result, HEP surveys and habitat unit calculations were completed as much as seven years prior to acquiring the sites. The term 'Shillapoo Wildlife Area' will be used to describe only the Herzog and Egger parcels in this document. Details and

  9. High Energy Physics (HEP) Homepage | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Programs » HEP Home High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » Intermediate Neutrino Research Program Awards ANNIE External link and PROSPECT External link will investigate the

  10. ORISE: U.S. Department of Homeland Security Summer Research Team Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    now accepting applications for 2015 now accepting applications for 2015 Summer Research Team Program with U.S. Department of Homeland Security Opportunities are open to research teams of faculty and students from Minority-Serving Institutions FOR IMMEDIATE RELEASE Nov. 25, 2014 FY15-03 OAK RIDGE, Tenn.-ORISE is currently accepting applications for the 2015 U.S. Department of Homeland Security Summer Research Team Program for Minority Serving Institutions (MSI). The program engages faculty

  11. ORISE: U.S. Department of Homeland Security is seeking faculty, graduate

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    students and undergraduate students for summer 2016 research programs U.S. Department of Homeland Security is seeking faculty, graduate students and undergraduate students for summer 2016 research programs Deadlines to apply occur in December 2015 FOR IMMEDIATE RELEASE Nov. 19, 2015 FY16-07 OAK RIDGE, Tenn.-The U.S. Department of Homeland Security (DHS) is seeking faculty, undergraduate and graduate students interested in participating in one of its 10-week programs in summer 2016, including

  12. An Object-oriented minimization package for HEP

    SciTech Connect (OSTI)

    Mark S Fischler and David Sachs

    2003-07-02

    A portion of the HEP community has perceived the need for a minimization package written in C++ and taking advantage of the Object-Oriented nature of that language. To be acceptable for HEP, such a package must at least encompass all the capabilities of Minuit. Aside from the slight plus of not relying on outside Fortran compilation, the advantages that a C++ package based on O-O design would confer over the multitude of available C++ Minuit-wrappers include: Easier extensibility to different algorithms and forms of constraints; and usage modes which would not be available in the global-common-based Minuit design. An example of the latter is a job pursuing two ongoing minimization problems simultaneously. We discuss the design and implementation of such a package, which extends Minuit only in minor ways but which greatly diminishes the programming effort (if not the algorithm thought) needed to make more significant extensions.

  13. Katrin Heitmann DOE HEP/ASCR Exascale Requirements Review

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Katrin Heitmann DOE HEP/ASCR Exascale Requirements Review June 10, 2015 Computational Cosmology Katrin Heitmann, Los Alamos National Laboratory Benasque Cosmology Workshop, August 2010 Roles of Cosmological Simulations in DE Survey Science * First part of end-to-end simulation * Control of systematics (1) Cosmology simulations and the survey (2) Solving the Inverse Problem from the LSST Science Book Cosmology Mock catalogs Athmosphere Optics Detector Images * Exploring fundamental physics *

  14. HEP-FCE Working Group on Libraries and Tools

    SciTech Connect (OSTI)

    Borgland, Anders; Elmer, Peter; Kirby, Michael; Patton, Simon; Potekhin, Maxim; Viren, Brett; Yanny, Brian

    2014-12-19

    The High-Energy Physics Forum for Computational Excellence (HEP-FCE) was formed by the Department of Energy as a follow-up to a recent report from the Topical Panel on Computing[1] and the associated P5 recommendation[2]. It is a pilot project distributed across the DOE Labs. During this initial incubation period the Forum is to develop a plan for a robust, long-term organization structure and a functioning web presence for forum activities and outreach, and a study of hardware and software needs across the HEP program. In the following sections we give this working group’s “vision” for aspects and qualities we wish to see in a future HEP-FCE. We then give a prioritized list of technical activities with suggested scoping and deliverables that can be expected to provide cross-experiment benefits. The remaining bulk of the report gives a technical survey of some specific “areas of opportunity” for cross-experiment benefit in the realm of software libs/tools. This survey serves as support for the vision and prioritized list. For each area we describe the ways that cross-experiment benefit is achieved today, as well as describe known failings or pitfalls where such benefit has failed to be achieved and which should be avoided in the future. For both cases, we try to give concrete examples. Each area then ends with an examination of what opportunities exist for improvements in that particular area.

  15. HEP Supported Workshops & Conferences | U.S. DOE Office of Science...

    Office of Science (SC) Website

    to learn more about a HEP-supported workshop or conference. Accelerators for America's Future External link Particle Accelerator Conference 2011 (PAC11) External link Fundamental...

  16. Measurements of the {sup 6}He+p resonant scattering

    SciTech Connect (OSTI)

    Condori, R. Pampa; Lichtenthler, R.; Lpine-Szily, A.; Gasques, L. R.; Morais, M. C.; Scarduelli, V. B.; Leistenschneider, E.; Alcntara-Nez, J. A.; Faria, P. N. de; Mendes Jr, D. R.; Pires, K. C. C.; Shorto, J. M. B.

    2014-11-11

    Measurements of the p({sup 6}He,p) elastic scattering excitation function have been performed in the RIBRAS system using a {sup 6}He secondary beam and a CH{sub 2} polyethylene thick target. The motivation is to observe states of the compound nucleus {sup 7}Li in the excitation energy range of E{sub exc}{sup 7Li}?=?10.8-11.8MeV, where the isobaric analog state of {sup 7}He ground state lies. Excitation functions have been obtained at three laboratory angles ?{sub lab} = 0, 20, and 25 which correspond to ?{sub c.m} = 180, 140, and 130.

  17. DOE O 484.1 Admin Chg 1, Reimbursable Work for the Department of Homeland Security

    Broader source: Energy.gov [DOE]

    The Department has made administrative changes to the above listed Directive. The order establishes DOE policies and procedures for the acceptance, performance, and administration of reimbursable work directly funded by the Department of Homeland Security. DOE N 481.1 and DOE N 251.62 are cancelled.

  18. Before the House Subcommittee on Emerging Threats, Cyber Security and Science and Technology Committee on Homeland Security

    Broader source: Energy.gov [DOE]

    Before the House Subcommittee on Emerging Threats, Cyber Security and Science and Technology Committee on Homeland SecurityBy: Patricia Hoffman, Acting Assistant Secretary for Electricity Delivery...

  19. NREL Earns Award For Efforts in Homeland Security - News Releases | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Earns Award For Efforts in Homeland Security February 10, 2004 Golden, Colo. - The Federal Laboratory Consortium for Technology (FLC) has recognized the Department of Energy's National Renewable Energy Laboratory with an award for Outstanding Technology Development in recognition of the Lab's long-term efforts for "Using Renewables to Safeguard the Energy Infrastructure of the U.S." "This award recognizes the outstanding work of all our Laboratory staff," said Tom Williams,

  20. Homeland security: safeguarding America's future with energy efficiency and renewable energy technologies

    SciTech Connect (OSTI)

    None, None

    2002-08-01

    The State Energy Advisory Board (STEAB) presents this 10th annual report following the one-year anniversary of the September 11, 2001 terrorist attacks on the World Trade Center and the Pentagon. This event has had profound impacts on all segments of American society, not the least of which is this countrys energy sector. Long before September 11, a number of energy issues grabbed the nations attention, including opening the Arctic National Wildlife Refuge to oil and natural gas exploration, the power crisis in California, nationwide natural gas and gasoline price increases, and the administrations May 2001 National Energy Policy. However, the events of September 11 refocused attention on the prominent role energy plays in the countrys homeland security. For the most part, the energy aspects of homeland security have focused on the physical security of critical energy emergency planning and energy infrastructure, such as power plants, refineries, and power and fuel transmission systems. While STEAB recognizes the importance of protecting our existing energy infrastructure, this should not be the sole focus of homeland security as it relates to energy.

  1. HEP Committees of Visitors | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Committees of Visitors HEP Committees of Visitors Print Text Size: A A A FeedbackShare Page High Energy Physics Advisory Panel (HEPAP) The links below provide an archive of High ...

  2. HEP User Facilities | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP User Facilities User Facilities User Facilities Home User Facilities at a Glance All User Facilities ASCR User Facilities BES User Facilities BER User Facilities FES User Facilities HEP User Facilities NP User Facilities User Resources User Statistics Policies and Processes Frequently Asked Questions User Facility Science Highlights User Facility News Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 P: (202) 586-5430 User

  3. Habitat Evaluation Procedures (HEP) Report : Grand Coulee Dam Mitigation, 1996-1999 Technical Report.

    SciTech Connect (OSTI)

    Kieffer, B.; Singer, Kelly; Abrahamson, Twa-le

    1999-07-01

    The purpose of this Habitat Evaluation Procedures (HEP) study was to determine baseline habitat units and to estimate future habitat units for Bonneville Power Administration (BPA) mitigation projects on the Spokane Indian Reservation. The mitigation between BPA and the Spokane Tribe of Indians (STOI) is for wildlife habitat losses on account of the construction of Grand Coulee Dam. Analysis of the HEP survey data will assist in mitigation crediting and appropriate management of the mitigation lands.

  4. Study of a Docker Use-Case for HEP

    SciTech Connect (OSTI)

    Kowalkowski, Jim; Lyon, Adam; Paterno, Marc

    2016-01-01

    Over the past few years, container technology has become increasingly promising as a means to seamlessly make our software available across a wider range of platforms. In December 2015, we decided to put together a set of docker images that serve as a demonstration of this container technology for managing a run-time environment for art-related software projects, and also serve as a set of test cases for evaluation of performance. Docker[1] containers provide a way to “wrap up a piece of software in a complete filesystem that contains everything it needs to run”. In combination with Shifter[2], such containers provide a way to run software developed and deployed on “typical” HEP platforms (such as SLF 6, in common use at Fermilab and on OSG platforms) on HPC facilities at NERSC. Docker containers provide a means of delivering software that can be run on a variety of hosts without needing to be compiled specially for each OS to be supported. This could substantially reduce the effort required to create and validate a new release, since one build could be suitable for use on both grid machines (both FermiGrid and OSG) as well as any machine capable of running the Docker container. In addition, docker containers may provide for a quick and easy way for users to install and use a software release in a standardized environment. This report contains the results and status of this demonstration and evaluation.

  5. Department of Homeland Security, Science and Technology Directorate, Borders and Maritime Security Division: Renewable Energy Research Roadmap

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Department of Homeland Security NNSA Receives Excellence Award for Radiological Security Enhancements in Hawaii HONOLULU - At an official event this week, the City and County of Honolulu presented the Department of Energy's (DOE) National Nuclear Security Administration (NNSA) with the Homeland Security Excellence Award for DOE/NNSA's Office of Radiological Security's (ORS) efforts... NNSA to Participate in Aerial Radiation Training Exercise in Philadelphia, Pennsylvania (WASHINGTON, D.C.) - On

  6. Risk Assessment Using The Homeland-Defense Operational Planning System (HOPS)

    SciTech Connect (OSTI)

    Price, D E; Durling, R L

    2005-10-10

    The Homeland-Defense Operational Planning System (HOPS), is a new operational planning tool leveraging Lawrence Livermore National Laboratory's expertise in weapons systems and in sparse information analysis to support the defense of the U.S. homeland. HOPS provides planners with a basis to make decisions to protect against acts of terrorism, focusing on the defense of facilities critical to U.S. infrastructure. Criticality of facilities, structures, and systems is evaluated on a composite matrix of specific projected casualty, economic, and sociopolitical impact bins. Based on these criteria, significant unidentified vulnerabilities are identified and secured. To provide insight into potential successes by malevolent actors, HOPS analysts strive to base their efforts mainly on unclassified open-source data. However, more cooperation is needed between HOPS analysts and facility representatives to provide an advantage to those whose task is to defend these facilities. Evaluated facilities include: refineries, major ports, nuclear power plants and other nuclear licensees, dams, government installations, convention centers, sports stadiums, tourist venues, and public and freight transportation systems. A generalized summary of analyses of U.S. infrastructure facilities will be presented.

  7. High-Resolution Laser-Induced Breakdown Spectroscopy used in Homeland Security and Forensic Applications

    SciTech Connect (OSTI)

    Martin, Madhavi Z; Wullschleger, Stan D; Vass, Arpad Alexander; Martin, Rodger Carl; Grissino-Mayer, Henri

    2006-01-01

    The technique of laser-induced breakdown spectroscopy (LIBS) to detect elements for a variety of homeland security applications such as nuclear materials identification and inventory,and forensic applications has been demonstrated. For nuclear materials applications, we detected and profiled metals in coatings that were used to encapsulate nuclear fuel. Multivariate analysis has been successfully employed in the quantification of elements present in treated wood and engineered wood composites. These examples demonstrate that LIBS-based techniques are inherently well suited for diverse environmental applications related to homeland security. Three key advantages are evident: (1) small samples (mg) are sufficient; (2) samples can be analyzed by LIBS very rapidly, and (3) biological materials such as human and animal bones and wood can be analyzed with minimal sample preparation. For forensic applications they have used LIBS to determine differences in animal and human bones. They have also applied this technique in the determination of counterfeit and non-counterfeit currency. They recently applied LIBS in helping to solve a murder case.

  8. Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells

    SciTech Connect (OSTI)

    Sekiya, Mika; Hiraishi, Ako; Touyama, Maiko [Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8572 (Japan); Sakamoto, Kazuichi [Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8572 (Japan)], E-mail: sakamoto@biol.tsukuba.ac.jp

    2008-10-31

    SREBP1c (sterol regulatory element-binding protein 1c) is a metabolic-syndrome-associated transcription factor that controls fatty acid biosynthesis under glucose/insulin stimulation. Oxidative stress increases lipid accumulation, which promotes the generation of reactive oxygen species (ROS). However, we know little about the role of oxidative stress in fatty acid biosynthesis. To clarify the action of oxidative stress in lipid accumulation via SREBP1c, we examined SREBP1c activity in H{sub 2}O{sub 2}-treated mammalian cells. We introduced a luciferase reporter plasmid carrying the SREBP1c-binding site into HepG2 or COS-7 cells. With increasing H{sub 2}O{sub 2} dose, SREBP1c transcriptional activity increased in HepG2 cells but declined in COS-7 cells. RT-PCR analysis revealed that mRNA expression of SREBP1c gene or of SREBP1c-regulated genes rose H{sub 2}O{sub 2} dose-dependently in HepG2 cells but dropped in COS-7 cells. Lipid accumulation and levels of the nuclear form of SREBP1c increased in H{sub 2}O{sub 2}-stimulated HepG2 cells. ROS may stimulate lipid accumulation in HepG2 cells via SREBP1c activation.

  9. Langston University - High Energy Physics (LU-HEP)

    SciTech Connect (OSTI)

    Snow, Dr., Joel

    2012-08-13

    as MC production coordinator MC production increased very significantly. In the first year of the PI's tenure as production coordinator production was 159M events and 6.7~TB of data. During the last year of the project period production was 2,342~M events and 262~TB of data. That is a factor of 15 increase in events and 39 in data volume. The increase occurred with improvements in computer hardware and networks, through the use of grid technology on diverse resources, and through increased automation and efficiency of the production process. LU HEP developed and deployed the automatic MC request processing system in use at FNAL. The complementary strategies of automation and grid production served DZero well. Fermilab has recognized LU HEP's contribution to DZero by allowing the PI to devote full time to research activities by appointing him a guest scientist for the last six years of the project period.

  10. HepSim: A Repository with Predictions for High-Energy Physics Experiments

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Chekanov, S. V.

    2015-01-01

    A file repository for calculations of cross sections and kinematic distributions using Monte Carlo generators for high-energy collisions is discussed. The repository is used to facilitate effective preservation and archiving of data from theoretical calculations and for comparisons with experimental data. The HepSim data library is publicly accessible and includes a number of Monte Carlo event samples with Standard Model predictions for current and future experiments. The HepSim project includes a software package to automate the process of downloading and viewing online Monte Carlo event samples. Data streaming over a network for end-user analysis is discussed.

  11. Compact Dielectric Wall Accelerator Development For Intensity Modulated Proton Therapy And Homeland Security Applications

    SciTech Connect (OSTI)

    Chen, Y -; Caporaso, G J; Guethlein, G; Sampayan, S; Akana, G; Anaya, R; Blackfield, D; Cook, E; Falabella, S; Gower, E; Harris, J; Hawkins, S; Hickman, B; Holmes, C; Horner, A; Nelson, S; Paul, A; Pearson, D; Poole, B; Richardson, R; Sanders, D; Stanley, J; Sullivan, J; Wang, L; Watson, J; Weir, J

    2009-06-17

    Compact dielectric wall (DWA) accelerator technology is being developed at the Lawrence Livermore National Laboratory. The DWA accelerator uses fast switched high voltage transmission lines to generate pulsed electric fields on the inside of a high gradient insulating (HGI) acceleration tube. Its high electric field gradients are achieved by the use of alternating insulators and conductors and short pulse times. The DWA concept can be applied to accelerate charge particle beams with any charge to mass ratio and energy. Based on the DWA system, a novel compact proton therapy accelerator is being developed. This proton therapy system will produce individual pulses that can be varied in intensity, energy and spot width. The system will be capable of being sited in a conventional linac vault and provide intensity modulated rotational therapy. The status of the developmental new technologies that make the compact system possible will be reviewed. These include, high gradient vacuum insulators, solid dielectric materials, SiC photoconductive switches and compact proton sources. Applications of the DWA accelerator to problems in homeland security will also be discussed.

  12. Department of Homeland Security's Science & Technology Directorate Announces New Cybersecurity Risk Analysis Tool on the Commercial Market

    Broader source: Energy.gov [DOE]

    The Department of Homeland Security (DHS) Science and Technology Directorate (S&T) announced that a fifth cybersecurity technology has been licensed for commercialization as a part of the Cyber Security Division's Transition to Practice (TTP) program, thanks to a new tool developed by researchers at the Department of Energy's Pacific Northwest National Laboratory.

  13. West Foster Creek 2007 Follow-up Habitat Evaluation Procedures (HEP) Report.

    SciTech Connect (OSTI)

    Ashley, Paul R.

    2008-02-01

    A follow-up habitat evaluation procedures (HEP) analysis was conducted on the West Foster Creek (Smith acquisition) wildlife mitigation site in May 2007 to determine the number of additional habitat units to credit Bonneville Power Administration (BPA) for providing funds to enhance and maintain the project site as partial mitigation for habitat losses associated with construction of Grand Coulee Dam. The West Foster Creek 2007 follow-up HEP survey generated 2,981.96 habitat units (HU) or 1.51 HUs per acre for a 34% increase (+751.34 HUs) above baseline HU credit (the 1999 baseline HEP survey generated 2,230.62 habitat units or 1.13 HUs per acre). The 2007 follow-up HEP analysis yielded 1,380.26 sharp-tailed grouse (Tympanuchus phasianellus) habitat units, 879.40 mule deer (Odocoileus hemionus) HUs, and 722.29 western meadowlark (Sturnella neglecta) habitat units. Mule deer and sharp-tailed grouse habitat units increased by 346.42 HUs and 470.62 HUs respectively over baseline (1999) survey results due largely to cessation of livestock grazing and subsequent passive restoration. In contrast, the western meadowlark generated slightly fewer habitat units in 2007 (-67.31) than in 1999, because of increased shrub cover, which lowers habitat suitability for that species.

  14. Deputy Assistant Secretary Matt Moury's Written Testimony Before the Subcommittee on Financial and Contracting Oversight Committee on Homeland Security and Government Affairs (March 11, 2014)

    Broader source: Energy.gov [DOE]

    Written statement of Deputy Assistant Secretary Matt Moury's Written Testimony Before the Subcommittee on Financial and Contracting Oversight Committee on Homeland Security and Government Affairs...

  15. Occupational Medicine - Assistant PIA, Idaho National Laboratory...

    Energy Savers [EERE]

    Occupational Medicine - Assistant PIA, Idaho National Laboratory Occupational Medicine - Assistant PIA, Idaho National Laboratory Occupational Medicine - Assistant PIA, Idaho...

  16. PIA - Richland Occupational Medicine Contract | Department of...

    Energy Savers [EERE]

    PIA - Richland Occupational Medicine Contract PIA - Richland Occupational Medicine Contract PIA - Richland Occupational Medicine Contract PDF icon PIA - Richland Occupational...

  17. Occupational Medicine | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Occupational Medicine The Occupational Medicine office provides medical surveillance examinations and consultations to Ames Laboratory and university employees according to federal and state regulations. The Occupational Medicine office enhances the efficiency of existing safety and health programs and assists in the reduction of workplace injuries and illnesses.

  18. Habitat Evaluation Procedures (HEP) Report : Hellsgate Project, 1999-2000 Technical Report.

    SciTech Connect (OSTI)

    Berger, Matthew

    2000-05-01

    A Habitat Evaluation Procedure (HEP) study was conducted on lands acquired and/or managed (4,568 acres total) by the Hellsgate Big Game Winter Range Wildlife Mitigation Project (Hellsgate project) to mitigate some of the losses associated with the original construction and operation of Grand Coulee Dam and inundation of habitats behind the dams. Three separate properties, totaling 2,224 acres were purchased in 1998. One property composed of two separate parcels, mostly grassland lies southeast of the town of Nespelem in Okanogan County (770 acres) and was formerly called the Hinman property. The former Hinman property lies within an area the Tribes have set aside for the protection and preservation of the sharp-tailed grouse (Agency Butte unit). This special management area minus the Hinman acquisition contains 2,388 acres in a long-term lease with the Tribes. The second property lies just south of the Silver Creek turnoff (Ferry County) and is bisected by the Hellsgate Road (part of the Friedlander unit). This parcel contains 60 acres of riparian and conifer forest cover. The third property (now named the Sand Hills unit) acquired for mitigation (1,394 acres) lies within the Hellsgate Reserve in Ferry County. This new acquisition links two existing mitigation parcels (the old Sand Hills parcels and the Lundstrum Flat parcel, all former Kuehne purchases) together forming one large unit. HEP team members included individuals from the Colville Confederated Tribes Fish and Wildlife Department (CTCR), Washington Department of Fish and Wildlife (WDFW), and Bureau of Land Management (BLM). The HEP team conducted a baseline habitat survey using the following HEP species models: mule deer (Odocoileus hemionus), mink (Mustela vison), downy woodpecker (Picoides pubescens), bobcat (Lynx rufus), yellow warbler (Dendroica petechia), and sharp-tailed grouse (Tympanuchus phasianellus columbianus). HEP analysis and results are discussed within the body of the text. The cover types

  19. Habitat Evaluation Procedures (HEP) Report; Precious Lands Wildlife Management Area, Technical Report 2000-2003.

    SciTech Connect (OSTI)

    Kozusko, Shana

    2003-12-01

    The Nez Perce Tribe (NPT) currently manages a 15,325 acre parcel of land known as the Precious Lands Wildlife Management Area that was purchased as mitigation for losses incurred by construction of the four lower Snake River dams. The Management Area is located in northern Wallowa County, Oregon and southern Asotin County, Washington (Figure 1). It is divided into three management parcels--the Buford parcel is located on Buford Creek and straddles the WA-OR state line, and the Tamarack and Basin parcels are contiguous to each other and located between the Joseph Creek and Cottonwood Creek drainages in Wallowa County, OR. The project was developed under the Pacific Northwest Electric Power Planning and Conservation Act of 1980 (P.L. 96-501), with funding from the Bonneville Power Administration (BPA). The acreage protected under this contract will be credited to BPA as habitat permanently dedicated to wildlife and wildlife mitigation. A modeling strategy known as Habitat Evaluation Procedure (HEP) was developed by the U.S. Fish and Wildlife Service and adopted by BPA as a habitat equivalency accounting system. Nine wildlife species models were used to evaluate distinct cover type features and provide a measure of habitat quality. Models measure a wide range of life requisite variables for each species and monitor overall trends in vegetation community health and diversity. One product of HEP is an evaluation of habitat quality expressed in Habitat Units (HUs). This HU accounting system is used to determine the amount of credit BPA receives for mitigation lands. After construction of the four lower Snake River dams, a HEP loss assessment was conducted to determine how many Habitat Units were inundated behind the dams. Twelve target species were used in that evaluation: Canada goose, mallard, river otter, downy woodpecker, song sparrow, yellow warbler, marsh wren, western meadowlark, chukar, ring-necked pheasant, California quail, and mule deer. The U.S. Army Corp of

  20. SAMPLING AND MASS SPECTROMETRY APPROACHES FOR THE DETECTION OF DRUGS AND FOREIGN CONTAMINANTS IN BREATH FOR HOMELAND SECURITY APPLICATIONS

    SciTech Connect (OSTI)

    Martin, A N

    2009-01-27

    Homeland security relies heavily on analytical chemistry to identify suspicious materials and persons. Traditionally this role has focused on attribution, determining the type and origin of an explosive, for example. But as technology advances, analytical chemistry can and will play an important role in the prevention and preemption of terrorist attacks. More sensitive and selective detection techniques can allow suspicious materials and persons to be identified even before a final destructive product is made. The work presented herein focuses on the use of commercial and novel detection techniques for application to the prevention of terrorist activities. Although drugs are not commonly thought of when discussing terrorism, narcoterrorism has become a significant threat in the 21st century. The role of the drug trade in the funding of terrorist groups is prevalent; thus, reducing the trafficking of illegal drugs can play a role in the prevention of terrorism by cutting off much needed funding. To do so, sensitive, specific, and robust analytical equipment is needed to quickly identify a suspected drug sample no matter what matrix it is in. Single Particle Aerosol Mass Spectrometry (SPAMS) is a novel technique that has previously been applied to biological and chemical detection. The current work applies SPAMS to drug analysis, identifying the active ingredients in single component, multi-component, and multi-tablet drug samples in a relatively non-destructive manner. In order to do so, a sampling apparatus was created to allow particle generation from drug tablets with on-line introduction to the SPAMS instrument. Rules trees were developed to automate the identification of drug samples on a single particle basis. A novel analytical scheme was also developed to identify suspect individuals based on chemical signatures in human breath. Human breath was sampled using an RTube{trademark} and the trace volatile organic compounds (VOCs) were preconcentrated using solid

  1. Habitat Evaluation Procedures (HEP) Report : Rainwater Wildlife Area, 1998-2001 Technical Report.

    SciTech Connect (OSTI)

    Childs, Allen

    2004-01-01

    The 8,768 acre Rainwater Wildlife Area was acquired in September 1998 by the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) through an agreement with Bonneville Power Administration (BPA) to partially offset habitat losses associated with construction of the John Day and McNary hydroelectric facilities on the mainstem Columbia River. U.S. Fish and Wildlife Service (USFWS) Habitat Evaluation Procedures (HEP) were used to determine the number of habitat units credited to BPA for acquired lands. Upland and riparian forest, upland and riparian shrub, and grassland rover types are evaluated in this study. Targeted wildlife species include downy woodpecker (Picoides pubescens), black-capped chickadee (Parus atricopillus), blue grouse (Dendragapus obscurus), great blue heron (Ardea herodias), yellow warbler (Dendroica petechia), mink (Mustela vison), and Western meadowlark (Sturnella neglects). Habitat surveys were conducted in 1998 and 1999 in accordance with published HEP protocols and included 65,300, 594m{sup 2} plots, and 112 one-tenth-acre plots. Between 153.3 and 7,187.46 acres were evaluated for each target wildlife mitigation species. Derived habitat suitability indices were multiplied by corresponding cover-type acreages to determine the number of habitat units for each species. The total baseline habitat units credited to BPA for the Rainwater Wildlife Area and its seven target species is 5,185.3 habitat units. Factors limiting habitat suitability are related to the direct, indirect, and cumulative effects of past livestock grazing, road construction, and timber harvest which have simplified the structure, composition, and diversity of native plant communities. Alternatives for protecting and improving habitat suitability include exclusion of livestock grazing, road de-commissioning/obliteration, reforestation and thinning, control of competing and unwanted vegetation (including noxious weeds), reestablishing displaced or reduced native

  2. Cyclosporine A and palmitic acid treatment synergistically induce cytotoxicity in HepG2 cells

    SciTech Connect (OSTI)

    Luo, Yi Rana, Payal; Will, Yvonne

    2012-06-01

    Immunosuppressant cyclosporine A (CsA) treatment can cause severe side effects. Patients taking immunosuppressant after organ transplantation often display hyperlipidemia and obesity. Elevated levels of free fatty acids have been linked to the etiology of metabolic syndromes, nonalcoholic fatty liver and steatohepatitis. The contribution of free fatty acids to CsA-induced toxicity is not known. In this study we explored the effect of palmitic acid on CsA-induced toxicity in HepG2 cells. CsA by itself at therapeutic exposure levels did not induce detectible cytotoxicity in HepG2 cells. Co-treatment of palmitic acid and CsA resulted in a dose dependent increase in cytotoxicity, suggesting that fatty acid could sensitize cells to CsA-induced cytotoxicity at the therapeutic doses of CsA. A synergized induction of caspase-3/7 activity was also observed, indicating that apoptosis may contribute to the cytotoxicity. We demonstrated that CsA reduced cellular oxygen consumption which was further exacerbated by palmitic acid, implicating that impaired mitochondrial respiration might be an underlying mechanism for the enhanced toxicity. Inhibition of c-Jun N-terminal kinase (JNK) attenuated palmitic acid and CsA induced toxicity, suggesting that JNK activation plays an important role in mediating the enhanced palmitic acid/CsA-induced toxicity. Our data suggest that elevated FFA levels, especially saturated FFA such as palmitic acid, may be predisposing factors for CsA toxicity, and patients with underlying diseases that would elevate free fatty acids may be susceptible to CsA-induced toxicity. Furthermore, hyperlipidemia/obesity resulting from immunosuppressive therapy may aggravate CsA-induced toxicity and worsen the outcome in transplant patients. -- Highlights: ? Palmitic acid and cyclosporine (CsA) synergistically increased cytotoxicity. ? The impairment of mitochondrial functions may contribute to the enhanced toxicity. ? Inhibition of JNK activity attenuated palmitate

  3. Nuclear medicine imaging system

    DOE Patents [OSTI]

    Bennett, Gerald W.; Brill, A. Bertrand; Bizais, Yves J. C.; Rowe, R. Wanda; Zubal, I. George

    1986-01-01

    A nuclear medicine imaging system having two large field of view scintillation cameras mounted on a rotatable gantry and being movable diametrically toward or away from each other is disclosed. In addition, each camera may be rotated about an axis perpendicular to the diameter of the gantry. The movement of the cameras allows the system to be used for a variety of studies, including positron annihilation, and conventional single photon emission, as well as static orthogonal dual multi-pinhole tomography. In orthogonal dual multi-pinhole tomography, each camera is fitted with a seven pinhole collimator to provide seven views from slightly different perspectives. By using two cameras at an angle to each other, improved sensitivity and depth resolution is achieved. The computer system and interface acquires and stores a broad range of information in list mode, including patient physiological data, energy data over the full range detected by the cameras, and the camera position. The list mode acquisition permits the study of attenuation as a result of Compton scatter, as well as studies involving the isolation and correlation of energy with a range of physiological conditions.

  4. Nuclear medicine imaging system

    DOE Patents [OSTI]

    Bennett, Gerald W.; Brill, A. Bertrand; Bizais, Yves J.; Rowe, R. Wanda; Zubal, I. George

    1986-01-07

    A nuclear medicine imaging system having two large field of view scintillation cameras mounted on a rotatable gantry and being movable diametrically toward or away from each other is disclosed. In addition, each camera may be rotated about an axis perpendicular to the diameter of the gantry. The movement of the cameras allows the system to be used for a variety of studies, including positron annihilation, and conventional single photon emission, as well as static orthogonal dual multi-pinhole tomography. In orthogonal dual multi-pinhole tomography, each camera is fitted with a seven pinhole collimator to provide seven views from slightly different perspectives. By using two cameras at an angle to each other, improved sensitivity and depth resolution is achieved. The computer system and interface acquires and stores a broad range of information in list mode, including patient physiological data, energy data over the full range detected by the cameras, and the camera position. The list mode acquisition permits the study of attenuation as a result of Compton scatter, as well as studies involving the isolation and correlation of energy with a range of physiological conditions.

  5. BES-HEP Connections: Common Problems in Condensed Matter and High Energy Physics, Round Table Discussion

    SciTech Connect (OSTI)

    Fradkin, Eduardo; Maldacena, Juan; Chatterjee, Lali; Davenport, James W

    2015-02-02

    On February 2, 2015 the Offices of High Energy Physics (HEP) and Basic Energy Sciences (BES) convened a Round Table discussion among a group of physicists on ‘Common Problems in Condensed Matter and High Energy Physics’. This was motivated by the realization that both fields deal with quantum many body problems, share many of the same challenges, use quantum field theoretical approaches and have productively interacted in the past. The meeting brought together physicists with intersecting interests to explore recent developments and identify possible areas of collaboration.... Several topics were identified as offering great opportunity for discovery and advancement in both condensed matter physics and particle physics research. These included topological phases of matter, the use of entanglement as a tool to study nontrivial quantum systems in condensed matter and gravity, the gauge-gravity duality, non-Fermi liquids, the interplay of transport and anomalies, and strongly interacting disordered systems. Many of the condensed matter problems are realizable in laboratory experiments, where new methods beyond the usual quasi-particle approximation are needed to explain the observed exotic and anomalous results. Tools and techniques such as lattice gauge theories, numerical simulations of many-body systems, and tensor networks are seen as valuable to both communities and will likely benefit from collaborative development.

  6. Occupational Medicine Workshops and Webinars

    Broader source: Energy.gov [DOE]

    The DOE Annual Occupational Medicine Workshop & Webinar (OMWW) is a valuable training opportunity established by the Office of Health, Safety, and Security in support of hundreds of medical and allied health professionals located at over four dozen locations across the Department. Their vital work in the field of Occupational Medicine encompasses medical qualification examinations, injury and illness management, disability management, workers’ compensation, and much more.

  7. Occupational Medicine - Assistant PIA, Idaho National Laboratory |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Medicine - Assistant PIA, Idaho National Laboratory Occupational Medicine - Assistant PIA, Idaho National Laboratory Occupational Medicine - Assistant PIA, Idaho National Laboratory Occupational Medicine - Assistant PIA, Idaho National Laboratory (268.86 KB) More Documents & Publications Occupational Medical Surveillance System (OMSS) PIA, Idaho National Laboratory Occupational Injury & Illness System (01&15) PIA, Idaho National Laboratory PIA - INL Education

  8. Eicosapentaenoic acid (EPA) induced apoptosis in HepG2 cells through ROSCa{sup 2+}JNK mitochondrial pathways

    SciTech Connect (OSTI)

    Zhang, Yuanyuan; Han, Lirong; Qi, Wentao; Cheng, Dai; Ma, Xiaolei; Hou, Lihua; Cao, Xiaohong; Wang, Chunling

    2015-01-24

    Highlights: EPA evoked ROS formation, [Ca{sup 2+}]{sub c} accumulation, the opening of MPTP and the phosphorylation of JNK. EPA-induced [Ca{sup 2+}]{sub c} elevation was depended on production of ROS. EPA-induced ROS generation, [Ca{sup 2+}]{sub c} increase, and JNK activated caused MPTP opening. The apoptosis induced by EPA was related to release of cytochrome C through the MPTP. EPA induced HepG2 cells apoptosis through ROSCa{sup 2+}JNK mitochondrial pathways. - Abstract: Eicosapentaenoic acid (EPA), a well-known dietary n?3 PUFAS, has been considered to inhibit proliferation of tumor cells. However, the molecular mechanism related to EPA-induced liver cancer cells apoptosis has not been reported. In this study, we investigated the effect of EPA on HepG2 cells proliferation and apoptosis mechanism through mitochondrial pathways. EPA inhibited proliferation of HepG2 cells in a dose-dependent manner and had no significant effect on the cell viability of humor normal liver L-02 cells. It was found that EPA initially evoked ROS formation, leading to [Ca{sup 2+}]{sub c} accumulation and the mitochondrial permeability transition pore (MPTP) opening; EPA-induced HepG2 cells apoptosis was inhibited by N-acetylcysteine (NAC, an inhibitor of ROS), 1,2-bis (2-aminophenoxy) ethane-N,N,N?,N?-tetraacetic acid (BAPTA-AM, a chelator of calcium) and CsA (inhibitor of MPTP). The relationship between ROS production, the increase of cytoplasmic Ca and MPTP opening was detected. It seems that ROS may act as an upstream regulator of EPA-induced [Ca{sup 2+}]{sub c} generation, moreover, generation of ROS, overload of mitochondrial [Ca{sup 2+}]{sub c}, and JNK activated cause the opening of MPTP. Western blotting results showed that EPA elevated the phosphorylation status of JNK, processes associated with the ROS generation. Simultaneously, the apoptosis induced by EPA was related to release of cytochrome C from mitochondria to cytoplasm through the MPTP and activation of

  9. OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle

    SciTech Connect (OSTI)

    Zhong, Wenbin; Zhou, You; Li, Jiwei; Mysore, Raghavendra; Luo, Wei; Li, Shiqian; Chang, Mau-Sun; Olkkonen, Vesa M.; Yan, Daoguang

    2014-04-01

    We earlier identified OSBP-related protein 8 (ORP8) as an endoplasmic reticulum/nuclear envelope oxysterol-binding protein implicated in cellular lipid homeostasis, migration, and organization of the microtubule cytoskeleton. Here, a yeast two-hybrid screen identified Homo sapiens sperm associated antigen 5 (SPAG5)/Astrin as interaction partner of ORP8. The putative interaction was further confirmed by pull-down and co-immunoprecipitation assays. ORP8 did not colocalize with kinetochore-associated SPAG5 in mitotic HepG2 or HuH7 cells, but overexpressed ORP8 was capable of recruiting SPAG5 onto endoplasmic reticulum membranes in interphase cells. In our experiments, 25-hydroxycholesterol (25OHC) retarded the HepG2 cell cycle, causing accumulation in G2/M phase; ORP8 overexpression resulted in the same phenotype. Importantly, ORP8 knock-down dramatically inhibited the oxysterol effect on HepG2 cell cycle, suggesting a mediating role of ORP8. Furthermore, knock-down of SPAG5 significantly reduced the effects of both ORP8 overexpression and 25OHC on the cell cycle, placing SPAG5 downstream of the two cell-cycle interfering factors. Taken together, the present results suggest that ORP8 may via SPAG5 mediate oxysterol interference of the HepG2 cell cycle. - Highlights: The oxysterol-binding protein ORP8 was found to interact with the mitotic regulator SPAG5/Astrin. Treatment of HepG2 cells with 25-hydroxycholesterol caused cell cycle retardation in G2/M. ORP8 overexpression caused a similar G2/M accumulation, and ORP8 knock-down reversed the 25-hydroxycholesterol effect. Reduction of cellular of SPAG5/Astrin reversed the cell cycle effects of both 25-hydroxycholesterol and ORP8 overexpression. Our results suggest that ORP8 mediates via SPAG5/Astrin the oxysterol interference of HepG2 cell cycle.

  10. AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS...

    Office of Scientific and Technical Information (OSTI)

    Converting energy to medical progress nuclear medicine NONE 62 RADIOLOGY AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS; NUCLEAR MEDICINE; PATIENTS; RADIATION...

  11. RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; NUCLEAR MEDICINE; HISTORICAL

    Office of Scientific and Technical Information (OSTI)

    The early days Richards, P. 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; NUCLEAR MEDICINE; HISTORICAL ASPECTS; TECHNETIUM 99; COLLOIDS; MOLYBDENUM...

  12. LRD-22, a novel dual dithiocarbamatic acid ester, inhibits Aurora-A kinase and induces apoptosis and cell cycle arrest in HepG2 cells

    SciTech Connect (OSTI)

    Wang, Huiling; Li, Ridong; Li, Li; Ge, Zemei; Zhou, Rouli; Li, Runtao

    2015-02-27

    In this study we investigated the antitumor activity of the novel dual dithiocarbamatic acid ester LRD-22 in vitro and in vivo. Several cancer cell lines were employed to determine the effect of LRD-22 on cell growth, and the MTT assay showed there was a significant decrease in viable tumor cell numbers in the presence of LRD-22, especially in the HepG2 cell line. Colony formation assay also showed LRD-22 strongly inhibits HepG2 cell growth. Evaluation of the mechanism involved showed that inhibitory effects of LRD-22 on cell growth are due to induction of apoptosis and G2/M arrest. LRD-22 inhibited Aurora-A phosphorylation at Thr{sub 288} and subsequently impaired p53 phosphorylation at Ser{sub 315} which was associated with the proteasome degradation pathway. Tumor suppressor protein p53 is stabilized by this mechanism and accumulates through inhibition of Aurora-A kinase activity via treatment with LRD-22. In vivo study of HepG2 xenograft in nude mice also shows LRD-22 suppresses tumor growth at a concentration of 5 mg/kg without animals suffering loss of body weight. In conclusion, our results demonstrate LRD-22 acts as an Aurora-A kinase inhibitor to induce apoptosis and inhibit proliferation in HepG2 cells, and should be considered as a promising targeting agent for HCC therapy. - Highlights: • LRD-22 significantly inhibits cancer cell growth, especially in the HepG2 cell line. • The inhibitory effect of LRD-22 is due to induction of apoptosis and cell cycle arrest. • LRD-22 inhibits Aurora-A phosphorylation which results in subsequent impairment of the p53 pathway. • LRD-22 suppresses tumor growth in xenograft mice without body weight loss.

  13. Impact of Nuclear Medicine on Emergency Response

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    February » Impact of Nuclear Medicine on Emergency Response Impact of Nuclear Medicine on Emergency Response WHEN: Feb 26, 2016 6:00 PM - 8:00 PM WHERE: Courtyard Marriott, Santa Fe CONTACT: Evelyn Mullen (505) 665-7576 CATEGORY: Community TYPE: Meeting INTERNAL: Calendar Login Event Description A number of novel isotopes and associated drug compounds are being developed, both in the US and elsewhere, for diagnosis and therapy in the field of nuclear medicine. The accelerator at Los Alamos is

  14. ORISE: Radiation Emergency Medicine - Continuing Medical Education...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Radiation Emergency Medicine Dates Scheduled Register Online August 9-12, 2016 Fee: 200 ... The course begins with a discussion of the fundamentals of radiation physics, radiation ...

  15. Medicine Lake Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Page Technique Activity Start Date Activity End Date Reference Material Geothermal Literature Review At Medicine Lake Geothermal Area (1984) Geothermal Literature Review 1984...

  16. Department of Homeland Security | NISAC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Disclosure | Department of Energy Department of Energy-funded Bioenergy Research Centers File 500th Invention Disclosure Department of Energy-funded Bioenergy Research Centers File 500th Invention Disclosure March 7, 2016 - 2:47pm Addthis News release from Oak Ridge National Laboratory and the Great Lakes Bioenergy Research Center OAK RIDGE, Tenn., March 3, 2016-Three U.S. Department of Energy-funded research centers - the BioEnergy Science Center (Oak Ridge National Laboratory), the Great

  17. Homeland Security Presidential Directive 7

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... confidence in our national economic and political institutions. (8) Federal departments ... Federal infrastructure protection and risk management activities within and across ...

  18. PIA - Richland Occupational Medicine Contract | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Medicine Contract PIA - Richland Occupational Medicine Contract PIA - Richland Occupational Medicine Contract PIA - Richland Occupational Medicine Contract (60.05 KB) More Documents & Publications Occupational Medical Surveillance System (OMSS) PIA, Idaho National Laboratory Occupational Medicine - Assistant PIA, Idaho National Laboratory

  19. Internalisation and multiple phosphorylation of γ-Conglutin, the lupin seed glycaemia-lowering protein, in HepG2 cells

    SciTech Connect (OSTI)

    Capraro, Jessica; Magni, Chiara; Faoro, Franco; Maffi, Dario; Scarafoni, Alessio; Tedeschi, Gabriella; Maffioli, Elisa; Parolari, Anna; Manzoni, Cristina; Lovati, Maria Rosa; Duranti, Marcello

    2013-08-09

    Highlights: •A glycaemia-reducing lupin seed protein is internalized by HepG2 cells. •The protein accumulates in the cytosol in an intact form. •The internalized protein is multiply phosphorylated. -- Abstract: Lupin seed γ-Conglutin is a protein capable of reducing glycaemia in mammalians and increasing glucose uptake by model cells. This work investigated whether γ-Conglutin is internalised into the target cells and undergoes any covalent change during the process, as a first step to understanding its mechanism of action. To this purpose, γ-Conglutin-treated and untreated HepG2 cells were submitted to confocal and transmission electron microscopy. Immune-revelation of γ-Conglutin at various intervals revealed its accumulation inside the cytosol. In parallel, 2D-electrophoresis of the cell lysates and antibody reaction of the blotted maps showed the presence of the protein intact subunits inside the treated cells, whilest no trace of the protein was found in the control cells. However, γ-Conglutin-related spots with an unexpectedly low pI were also observed in the maps. These spots were excised, trypsin-treated and submitted to MS/MS spectrometric analysis. The presence of phosphorylated amino acids was detected. These findings, by showing that γ-Conglutin is internalised by HepG2 cells in an intact form and is modified by multiple phosphorylation, open the way to the understanding of the lupin γ-Conglutin insulin-mimetic activity.

  20. Silica bioreplication preserves three-dimensional spheroid structures of human pluripotent stem cells and HepG2 cells

    SciTech Connect (OSTI)

    Lou, Yan-Ru; Kanninen, Liisa; Kaehr, Bryan; Townson, Jason L.; Niklander, Johanna; Harjumäki, Riina; Jeffrey Brinker, C.; Yliperttula, Marjo

    2015-09-01

    Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, they are increasingly employed as models for cancer and drug research, as well as tissue engineering. It has proven challenging to stabilize spheroid architectures for detailed morphological examination. Here we overcome this issue using a silica bioreplication (SBR) process employed on spheroids formed from human pluripotent stem cells (hPSCs) and hepatocellular carcinoma HepG2 cells cultured in the nanofibrillar cellulose (NFC) hydrogel. The cells in the spheroids are more round and tightly interacting with each other than those in 2D cultures, and they develop microvilli-like structures on the cell membranes as seen in 2D cultures. Furthermore, SBR preserves extracellular matrix-like materials and cellular proteins. In conclusion, these findings provide the first evidence of intact hPSC spheroid architectures and similar fine structures to 2D-cultured cells, providing a pathway to enable our understanding of morphogenesis in 3D cultures.

  1. Silica bioreplication preserves three-dimensional spheroid structures of human pluripotent stem cells and HepG2 cells

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Lou, Yan-Ru; Kanninen, Liisa; Kaehr, Bryan; Townson, Jason L.; Niklander, Johanna; Harjumäki, Riina; Jeffrey Brinker, C.; Yliperttula, Marjo

    2015-09-01

    Three-dimensional (3D) cell cultures produce more in vivo-like multicellular structures such as spheroids that cannot be obtained in two-dimensional (2D) cell cultures. Thus, they are increasingly employed as models for cancer and drug research, as well as tissue engineering. It has proven challenging to stabilize spheroid architectures for detailed morphological examination. Here we overcome this issue using a silica bioreplication (SBR) process employed on spheroids formed from human pluripotent stem cells (hPSCs) and hepatocellular carcinoma HepG2 cells cultured in the nanofibrillar cellulose (NFC) hydrogel. The cells in the spheroids are more round and tightly interacting with each other than thosemore » in 2D cultures, and they develop microvilli-like structures on the cell membranes as seen in 2D cultures. Furthermore, SBR preserves extracellular matrix-like materials and cellular proteins. In conclusion, these findings provide the first evidence of intact hPSC spheroid architectures and similar fine structures to 2D-cultured cells, providing a pathway to enable our understanding of morphogenesis in 3D cultures.« less

  2. Federal technology transfer requirements :a focused study of principal agencies approaches with implications for the Department of Homeland Security.

    SciTech Connect (OSTI)

    Koker, Denise; Micheau, Jill M.

    2006-07-01

    This report provides relevant information and analysis to the Department of Homeland Security (DHS) that will assist DHS in determining how to meet the requirements of federal technology transfer legislation. These legal requirements are grouped into five categories: (1) establishing an Office of Research and Technology Applications, or providing the functions thereof; (2) information management; (3) enabling agreements with non-federal partners; (4) royalty sharing; and (5) invention ownership/obligations. These five categories provide the organizing framework for this study, which benchmarks other federal agencies/laboratories engaged in technology transfer/transition Four key agencies--the Department of Health & Human Services (HHS), the U.S. Department of Agriculture (USDA), the Department of Energy (DOE), and the Department of Defense (DoD)--and several of their laboratories have been surveyed. An analysis of DHS's mission needs for commercializing R&D compared to those agencies/laboratories is presented with implications and next steps for DHS's consideration. Federal technology transfer legislation, requirements, and practices have evolved over the decades as agencies and laboratories have grown more knowledgeable and sophisticated in their efforts to conduct technology transfer and as needs and opinions in the federal sector have changed with regards to what is appropriate. The need to address requirements in a fairly thorough manner has, therefore, resulted in a lengthy paper. There are two ways to find summary information. Each chapter concludes with a summary, and there is an overall ''Summary and Next Steps'' chapter on pages 57-60. For those readers who are unable to read the entire document, we recommend referring to these pages.

  3. Improved Meteorological Input for Atmospheric Release Decision support Systems and an Integrated LES Modeling System for Atmospheric Dispersion of Toxic Agents: Homeland Security Applications

    SciTech Connect (OSTI)

    Arnold, E; Simpson, M; Larsen, S; Gash, J; Aluzzi, F; Lundquist, J; Sugiyama, G

    2010-04-26

    When hazardous material is accidently or intentionally released into the atmosphere, emergency response organizations look to decision support systems (DSSs) to translate contaminant information provided by atmospheric models into effective decisions to protect the public and emergency responders and to mitigate subsequent consequences. The Department of Homeland Security (DHS)-led Interagency Modeling and Atmospheric Assessment Center (IMAAC) is one of the primary DSSs utilized by emergency management organizations. IMAAC is responsible for providing 'a single piont for the coordination and dissemination of Federal dispersion modeling and hazard prediction products that represent the Federal position' during actual or potential incidents under the National Response Plan. The Department of Energy's (DOE) National Atmospheric Release Advisory Center (NARAC), locatec at the Lawrence Livermore National Laboratory (LLNL), serves as the primary operations center of the IMAAC. A key component of atmospheric release decision support systems is meteorological information - models and data of winds, turbulence, and other atmospheric boundary-layer parameters. The accuracy of contaminant predictions is strongly dependent on the quality of this information. Therefore, the effectiveness of DSSs can be enhanced by improving the meteorological options available to drive atmospheric transport and fate models. The overall goal of this project was to develop and evaluate new meteorological modeling capabilities for DSSs based on the use of NASA Earth-science data sets in order to enhance the atmospheric-hazard information provided to emergency managers and responders. The final report describes the LLNL contributions to this multi-institutional effort. LLNL developed an approach to utilize NCAR meteorological predictions using NASA MODIS data for the New York City (NYC) region and demonstrated the potential impact of the use of different data sources and data parameterizations on

  4. Converting energy to medical progress [nuclear medicine] (Technical...

    Office of Scientific and Technical Information (OSTI)

    Converting energy to medical progress nuclear medicine Citation Details In-Document Search Title: Converting energy to medical progress nuclear medicine You are accessing a ...

  5. Medicine Bow Wind Farm II | Open Energy Information

    Open Energy Info (EERE)

    II Jump to: navigation, search Name Medicine Bow Wind Farm II Facility Medicine Bow Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Platte...

  6. Medicine Bow Wind Farm IV | Open Energy Information

    Open Energy Info (EERE)

    IV Jump to: navigation, search Name Medicine Bow Wind Farm IV Facility Medicine Bow Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Platte...

  7. Static Temperature Survey At Medicine Lake Area (Warpinski, Et...

    Open Energy Info (EERE)

    GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Static Temperature Survey At Medicine Lake Area (Warpinski, Et Al., 2002) Exploration Activity Details Location Medicine...

  8. Mercury Vapor At Medicine Lake Area (Kooten, 1987) | Open Energy...

    Open Energy Info (EERE)

    Medicine Lake Area (Kooten, 1987) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Mercury Vapor At Medicine Lake Area (Kooten, 1987) Exploration...

  9. Medicine Bow Wind Farm III | Open Energy Information

    Open Energy Info (EERE)

    III Jump to: navigation, search Name Medicine Bow Wind Farm III Facility Medicine Bow Sector Wind energy Facility Type Small Scale Wind Facility Status In Service Owner Platte...

  10. Medicine Hot Springs Pool & Spa Low Temperature Geothermal Facility...

    Open Energy Info (EERE)

    Pool & Spa Low Temperature Geothermal Facility Jump to: navigation, search Name Medicine Hot Springs Pool & Spa Low Temperature Geothermal Facility Facility Medicine Hot...

  11. Medicine Bow Wind Farm I | Open Energy Information

    Open Energy Info (EERE)

    I Jump to: navigation, search Name Medicine Bow Wind Farm I Facility Medicine Bow Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Platte...

  12. Symes Hotel and Medicinal Springs Pool & Spa Low Temperature...

    Open Energy Info (EERE)

    Symes Hotel and Medicinal Springs Pool & Spa Low Temperature Geothermal Facility Jump to: navigation, search Name Symes Hotel and Medicinal Springs Pool & Spa Low Temperature...

  13. Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans

    SciTech Connect (OSTI)

    Atienzar, Franck A.; Novik, Eric I.; Gerets, Helga H.; Parekh, Amit; Delatour, Claude; Cardenas, Alvaro; MacDonald, James; Yarmush, Martin L.; Dhalluin, Stphane

    2014-02-15

    Drug Induced Liver Injury (DILI) is a major cause of attrition during early and late stage drug development. Consequently, there is a need to develop better in vitro primary hepatocyte models from different species for predicting hepatotoxicity in both animals and humans early in drug development. Dog is often chosen as the non-rodent species for toxicology studies. Unfortunately, dog in vitro models allowing long term cultures are not available. The objective of the present manuscript is to describe the development of a co-culture dog model for predicting hepatotoxic drugs in humans and to compare the predictivity of the canine model along with primary human hepatocytes and HepG2 cells. After rigorous optimization, the dog co-culture model displayed metabolic capacities that were maintained up to 2 weeks which indicates that such model could be also used for long term metabolism studies. Most of the human hepatotoxic drugs were detected with a sensitivity of approximately 80% (n = 40) for the three cellular models. Nevertheless, the specificity was low approximately 40% for the HepG2 cells and hepatocytes compared to 72.7% for the canine model (n = 11). Furthermore, the dog co-culture model showed a higher superiority for the classification of 5 pairs of close structural analogs with different DILI concerns in comparison to both human cellular models. Finally, the reproducibility of the canine system was also satisfactory with a coefficient of correlation of 75.2% (n = 14). Overall, the present manuscript indicates that the dog co-culture model may represent a relevant tool to perform chronic hepatotoxicity and metabolism studies. - Highlights: Importance of species differences in drug development. Relevance of dog co-culture model for metabolism and toxicology studies. Hepatotoxicity: higher predictivity of dog co-culture vs HepG2 and human hepatocytes.

  14. Report on Department of Homeland Security Sponsored Research Project at Lawrence Livermore National Laboratory on Preparation for an Improvised Nuclear Device Event

    SciTech Connect (OSTI)

    A., B

    2008-07-31

    Following the events of September 11th, a litany of imaginable horribles was trotted out before an anxious and concerned public. To date, government agencies and academics are still grappling with how to best respond to such catastrophes, and as Senator Lieberman's quote says above, now is the time to plan and prepare for such events. One of the nation's worst fears is that terrorists might detonate an improvised nuclear device (IND) in an American city. With 9/11 serving as the catalyst, the government and many NGOs have invested money into research and development of response capabilities throughout the country. Yet, there is still much to learn about how to best respond to an IND event. My summer 2008 internship at Lawrence Livermore National Laboratory afforded me the opportunity to look in depth at the preparedness process and the research that has been conducted on this issue. While at the laboratory I was tasked to collect, combine, and process research on how cities and the federal government can best prepare for the horrific prospect of an IND event. Specific projects that I was involved with were meeting reports, research reviews, and a full project report. Working directly with Brooke Buddemeier and his support team at the National Atmospheric Release Advisory Center, I was able to witness first hand, preparation for meetings with response planners to inform them of the challenges that an IND event would pose to the affected communities. In addition, I supported the Homeland Security Institute team (HSI), which was looking at IND preparation and preparing a Congressional report. I participated in meetings at which local responders expressed their concerns and contributed valuable information to the response plan. I specialized in the psycho-social aspects of an IND event and served as a technical advisor to some of the research groups. Alongside attending and supporting these meetings, I worked on an independent research project which collected

  15. HEP Science Highlights

    Office of Science (SC) Website

    neutrinos and antineutrinos are the same particle, and to see if neutrinos respect a natural symmetry, the reversal of time, need to be carried out. The discovery also...

  16. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALCF Future Systems June 10, 2015 | Author(s): Tim Williams | Download File: ExascaleReqsHEPALCF3systems.pdf | pdf | 3.1 MB ASCR Facility Plans June 10, 2015 | Author(s): Sudip...

  17. HEP Final Project Report

    SciTech Connect (OSTI)

    Chen, Chunhui

    2013-05-21

    In this report, we summarize the research activity funded by the DOE award DE-FG02-12ER41827 (DE-SC0007892) during the funding period (May 1, 2012- March 31, 2013).

  18. HEP Open Funding Opportunities

    Office of Science (SC) Website

    - and is the principal federal funding agency of - the Nation's research programs in high-energy physics, nuclear physics, and fusion energy sciences. en 8BF3F791-EE84-4768-BCDF-E...

  19. hep.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HPC Requirements Workshop: Cosmic Microwave Background Data Simulation & Analysis Julian Borrill Computational Cosmology Center, Berkeley Lab & Space Sciences Laboratory, UC Berkeley Overview * 3 NERSC repositories - mp107: O(10) NSF/NASA/DOE/international suborbital experiments - planck: current ESA/NASA satellite mission (with DOE IAA) - cmbpol: proposed NASA satellite mission * O(100) users, 4 projects (Planck, EBEX, PolarBear, QUIET), 2 modules (cmb, planck) * LBNL/UC Berkeley,

  20. Biology and Medicine Division: Annual report 1986

    SciTech Connect (OSTI)

    Not Available

    1987-04-01

    The Biology and Medicine Division continues to make important contributions in scientific areas in which it has a long-established leadership role. For 50 years the Division has pioneered in the application of radioisotopes and charged particles to biology and medicine. There is a growing emphasis on cellular and molecular applications in the work of all the Division's research groups. The powerful tools of genetic engineering, the use of recombinant products, the analytical application of DNA probes, and the use of restriction fragment length polymorphic DNA are described and proposed for increasing use in the future.

  1. Geothermal Literature Review At Medicine Lake Geothermal Area...

    Open Energy Info (EERE)

    navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Geothermal Literature Review At Medicine Lake Geothermal Area (1984) Exploration Activity Details Location...

  2. Therapeutic potential of nanoceria in regenerative medicine

    SciTech Connect (OSTI)

    Das, Soumen; Chigurupati, Srinivasulu; Dowding, Janet; Munusamy, Prabhakaran; Baer, Donald R.; McGinnis, James F.; Mattson, Mark P.; Self, William; Seal, Sudipta

    2014-11-01

    Tissue engineering and regenerative medicine aim to achieve functional restoration of tissue or cells damaged through disease, aging or trauma. Advancement of tissue engineering requires innovation in the field of 3D scaffolding, and functionalization with bioactive molecules. Nanotechnology offers advanced materials with patterned nano-morphologies for cell growth and different molecular substrates which can support cell survival and functions. Cerium oxide nanoparticles (nanoceria) can control intracellular as well as extracellular reactive oxygen and nitrogen species. Recent findings suggest that nanoceria can enhance long-term cell survival, enable cell migration and proliferation, and promote stem cell differentiation. Moreover, the self-regenerative property of nanoceria permits a small dose to remain catalytically active for extended time. This review summarizes the possibilities and applications of nanoceria in the field of tissue engineering and regenerative medicine.

  3. (Coordinated research programs in nuclear medicine)

    SciTech Connect (OSTI)

    Knapp, F.F. Jr.

    1990-10-03

    The traveler visited the Clinic for Nuclear Medicine at the University of Bonn, West Germany, to review, organize, and plan collaborative studies. He also met with the editorial board of the journal NucCompact -- European/American Communications in Nuclear Medicine, on which he serves as US editor. He also visited colleagues at the Cyclotron Research Center (CRC) at the University of Liege, Belgium, to coordinate clinical applications of the ultrashort-lived iridium-191m radionuclide obtained from the osmium-190/iridium-191m generator system. The traveler planned and coordinated continuing collaboration with colleagues at the CRC for further applications of this generator system. He also visited the University of Metz, Metz, France, to organize a three-center project for the synthesis and evaluation of various receptor-specific cerebral imaging agents, involving the Oak Ridge National Laboratory (ORNL), CRC, and the University of Metz.

  4. Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit

    SciTech Connect (OSTI)

    Boylan, Joan M.; Salomon, Arthur R.; Tantravahi, Umadevi; Gruppuso, Philip A.

    2015-07-15

    Protein phosphatase 6 (PP6) is a ubiquitous Ser/Thr phosphatase involved in an array of cellular processes. To assess the potential of PP6 as a therapeutic target in liver disorders, we attenuated expression of the PP6 catalytic subunit in HepG2 cells using lentiviral-transduced shRNA. Two PP6 knock-down (PP6KD) cell lines (90% reduction of PP6-C protein content) were studied in depth. Both proliferated at a rate similar to control cells. However, flow cytometry indicated G2/M cell cycle arrest that was accounted for by a shift of the cells from a diploid to tetraploid state. PP6KD cells did not show an increase in apoptosis, nor did they exhibit reduced viability in the presence of bleomycin or taxol. Gene expression analysis by microarray showed attenuated anti-inflammatory signaling. Genes associated with DNA replication were downregulated. Mass spectrometry-based phosphoproteomic analysis yielded 80 phosphopeptides representing 56 proteins that were significantly affected by a stable reduction in PP6-C. Proteins involved in DNA replication, DNA damage repair and pre-mRNA splicing were overrepresented among these. PP6KD cells showed intact mTOR signaling. Our studies demonstrated involvement of PP6 in a diverse set of biological pathways and an adaptive response that may limit the effectiveness of targeting PP6 in liver disorders. - Highlights: • Lentiviral-transduced shRNA was used to generate a stable knockdown of PP6 in HepG2 cells. • Cells adapted to reduced PP6; cell proliferation was unaffected, and cell survival was normal. • However, PP6 knockdown was associated with a transition to a tetraploid state. • Genomic profiling showed downregulated anti-inflammatory signaling and DNA replication. • Phosphoproteomic profiling showed changes in proteins associated with DNA replication and repair.

  5. Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells

    SciTech Connect (OSTI)

    Chen, Yue; Zhang, Shunfen; Zhou, Tianyan; Huang, Chaoqun; McLaughlin, Alicia; Chen, Guangping

    2013-04-15

    Cytosolic sulfotransferases are one of the major families of phase II drug metabolizing enzymes. Sulfotransferase-catalyzed sulfonation regulates hormone activities, metabolizes drugs, detoxifies xenobiotics, and bioactivates carcinogens. Human dehydroepiandrosterone sulfotransferase (hSULT2A1) plays important biological roles by sulfating endogenous hydroxysteroids and exogenous xenobiotics. Genistein, mainly existing in soy food products, is a naturally occurring phytoestrogen with both chemopreventive and chemotherapeutic potential. Our previous studies have shown that genistein significantly induces hSULT2A1 in Hep G2 and Caco-2 cells. In this study, we investigated the roles of liver X receptor (LXRα) in the genistein induction of hSULT2A1. LXRs have been shown to induce expression of mouse Sult2a9 and hSULT2A1 gene. Our results demonstrate that LXRα mediates the genistein induction of hSULT2A1, supported by Western blot analysis results, hSULT2A1 promoter driven luciferase reporter gene assay results, and mRNA interference results. Chromatin immunoprecipitation (ChIP) assay results demonstrate that genistein increase the recruitment of hLXRα binding to the hSULT2A1 promoter. These results suggest that hLXRα plays an important role in the hSULT2A1 gene regulation. The biological functions of phytoestrogens may partially relate to their induction activity toward hydroxysteroid SULT. - Highlights: ► Liver X receptor α mediated genistein induction of hSULT2A1 in Hep G2 cells. ► LXRα and RXRα dimerization further activated this induction. ► Western blot results agreed well with luciferase reporter gene assay results. ► LXRs gene silencing significantly decreased hSULT2A1 expression. ► ChIP analysis suggested that genistein enhances hLXRα binding to the hSULT2A1 promoter.

  6. Plasmatic concentration of organochlorine lindane acts as metabolic disruptors in HepG2 liver cell line by inducing mitochondrial disorder

    SciTech Connect (OSTI)

    Benarbia, Mohammed el Amine; Macherel, David; Faure, Sbastien; Jacques, Caroline; Andriantsitohaina, Ramaroson; Malthiry, Yves

    2013-10-15

    Lindane (LD) is a persistent environmental pollutant that has been the subject of several toxicological studies. However, concentrations used in most of the reported studies were relatively higher than those found in the blood of the contaminated area residents and effects of low concentrations remain poorly investigated. Moreover, effects on cell metabolism and mitochondrial function of exposure to LD have received little attention. This study was designed to explore the effects of low concentrations of LD on cellular metabolism and mitochondrial function, using the hepatocarcinoma cell line HepG2. Cells were exposed to LD for 24, 48 and 72 h and different parameters linked with mitochondrial regulation and energy metabolism were analyzed. Despite having any impact on cellular viability, exposure to LD at plasmatic concentrations led to an increase of maximal respiratory capacity, complex I activity, intracellular ATP and NO release but decreased uncoupled respiration to ATP synthesis and medium lactate levels. In addition, LD exposure resulted in the upregulation of mitochondrial biogenesis genes. We suggest that, at plasmatic concentrations, LD acts as a metabolic disruptor through impaired mitochondrial function and regulation with an impact on cellular energetic metabolism. In addition, we propose that a cellular assay based on the analysis of mitochondria function, such as described here for LD, may be applicable for larger studies on the effects of low concentrations of xenobiotics, because of the exquisite sensitivity of this organelle. - Highlights: Our data clearly demonstrated in HepG2 cells that exposure at plasmatic low concentrations of LD were able to: Impair mitochondrial function Caused alteration on nucleo-mitochondrial cross-talk Increase nitric oxide release and protein nitration Impair cellular energetic metabolism and lipid accumulation.

  7. PRIVACY IMPACT ASSESSMENT: OCCUPATIONAL MEDICINE- INL OCCUPATIONAL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    OCCUPATIONAL MEDICINE- INL OCCUPATIONAL MEDICAL SUVEILLANCE SYSTEM (OMSS) PIA Template Version 3 - May, 2009 Department of Energy Privacy Impact Assessment (PIA) Guidance is provided in the template. See DOE Order 206.1, Department of Energy Privacy Program, Appendix A, Privacy Impact Assessments, for requirements and additional guidance for conducting a PIA: http://www.directives.doe.gov/pdfs/doe/doetextlneword/206/o2061.pdf Please complete electronically: no hand-written submissions will be

  8. PRIVACY IMPACT ASSESSMENT: Occupational Medicine Assistant PIA

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Medicine - Assistant PIA Template Version 3 - May, 2009 Department of Energy Privacy Impact Assessment (PIA) Guidance is provided in the template. See DOE Order 206.1, Deparlment of Energy Privacy Program, Appendix A, Privacy Impact Assessments, for requirements and additional guidance for conducting a PIA: http://www.directives.doe.gov/pdfs/doe/doetextlneword/206/o2061.pdf Please complete electronically: no hand-written submissions will be accepted. This template may not be modified. MODULE 1-

  9. Integrative Genomics and Computational Systems Medicine

    SciTech Connect (OSTI)

    McDermott, Jason E.; Huang, Yufei; Zhang, Bing; Xu, Hua; Zhao, Zhongming

    2014-01-01

    The exponential growth in generation of large amounts of genomic data from biological samples has driven the emerging field of systems medicine. This field is promising because it improves our understanding of disease processes at the systems level. However, the field is still in its young stage. There exists a great need for novel computational methods and approaches to effectively utilize and integrate various omics data.

  10. Converting Energy to Medical Progress [Nuclear Medicine

    DOE R&D Accomplishments [OSTI]

    2001-04-01

    For over 50 years the Office of Biological and Environmental Research (BER) of the United States Department of Energy (DOE) has been investing to advance environmental and biomedical knowledge connected to energy. The BER Medical Sciences program fosters research to develop beneficial applications of nuclear technologies for medical diagnosis and treatment of many diseases. Today, nuclear medicine helps millions of patients annually in the United States. Nearly every nuclear medicine scan or test used today was made possible by past BER-funded research on radiotracers, radiation detection devices, gamma cameras, PET and SPECT scanners, and computer science. The heart of biological research within BER has always been the pursuit of improved human health. The nuclear medicine of tomorrow will depend greatly on today's BER-supported research, particularly in the discovery of radiopharmaceuticals that seek specific molecular and genetic targets, the design of advanced scanners needed to create meaningful images with these future radiotracers, and the promise of new radiopharmaceutical treatments for cancers and genetic diseases.

  11. January 2013 Most Viewed Documents for Biology And Medicine ...

    Office of Scientific and Technical Information (OSTI)

    January 2013 Most Viewed Documents for Biology And Medicine Nevada Test Site Radiological Control Manual Radiological Control Managers' Council Nevada Test Site Effects of ionizing ...

  12. ORISE: Advanced Radiation Medicine | REAC/TS Continuing Medical...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Advanced Radiation Medicine Dates Scheduled Register Online August 15-19, 2016 Fee: 275 ... information on the diagnosis and management of ionizing radiation injuries and illnesses. ...

  13. The role of general nuclear medicine in breast cancer

    SciTech Connect (OSTI)

    Greene, Lacey R; Wilkinson, Deborah

    2015-03-15

    The rising incidence of breast cancer worldwide has prompted many improvements to current care. Routine nuclear medicine is a major contributor to a full gamut of clinical studies such as early lesion detection and stratification; guiding, monitoring, and predicting response to therapy; and monitoring progression, recurrence or metastases. Developments in instrumentation such as the high-resolution dedicated breast device coupled with the diagnostic versatility of conventional cameras have reinserted nuclear medicine as a valuable tool in the broader clinical setting. This review outlines the role of general nuclear medicine, concluding that targeted radiopharmaceuticals and versatile instrumentation position nuclear medicine as a powerful modality for patients with breast cancer.

  14. March 2016 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    March 2016 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. Brookhaven National Lab., Upton, NY (United ...

  15. Stepout-Deepening Wells At Medicine Lake Area (Warpinski, Et...

    Open Energy Info (EERE)

    2) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Stepout-Deepening Wells At Medicine Lake Area (Warpinski, Et Al., 2002) Exploration Activity...

  16. National Library of Medicine Web Resources for Student Health Professionals

    SciTech Connect (OSTI)

    Womble, R.

    2010-04-02

    Familiarize students affiliated with the Student National Medical Association with the National Library of Medicine's online resources that address medical conditions, health disparities, and public health preparedness needs.

  17. April 2013 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    April 2013 Most Viewed Documents for Biology And Medicine Publications in biomedical and environmental sciences programs, 1981 Moody, J.B. (comp.) (1982) 306 Drug Retention Times ...

  18. June 2015 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    June 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. Brookhaven National Lab., Upton, NY (United ...

  19. September 2015 Most Viewed Documents for Biology And Medicine...

    Office of Scientific and Technical Information (OSTI)

    September 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. Brookhaven National Lab., Upton, NY (United ...

  20. March 2014 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    March 2014 Most Viewed Documents for Biology And Medicine Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) ...

  1. Most Viewed Documents - Biology and Medicine | OSTI, US Dept...

    Office of Scientific and Technical Information (OSTI)

    - Biology and Medicine Drug Retention Times Center for Human Reliability Studies (2007) External dose-rate conversion factors for calculation of dose to the public Not Available ...

  2. December 2015 Most Viewed Documents for Biology And Medicine...

    Office of Scientific and Technical Information (OSTI)

    December 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. Brookhaven National Lab., Upton, NY (United ...

  3. DOE Research and Development Accomplishments Nobels in Medicine Associated

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    with the DOE and Predecessors Nobels in Medicine Associated with the DOE and Predecessors Information about affiliations: Office of Science DOE Nobel Laureates Alphabetical Listing Chronological Listing A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 2003 1997 1983 1979 1962 1958 1946 1934 Name Year Nobel Prize In Year Nobel Prize In B 2003 George Wells Beadle 1958 Physiology or Medicine Sir Peter Mansfield Physiology or Medicine C 1997 Allan M. Cormack 1979 Physiology or Medicine

  4. Inhibition of SH2-domain-containing inositol 5-phosphatase (SHIP2) ameliorates palmitate induced-apoptosis through regulating Akt/FOXO1 pathway and ROS production in HepG2 cells

    SciTech Connect (OSTI)

    Gorgani-Firuzjaee, Sattar; Adeli, Khosrow; Meshkani, Reza

    2015-08-21

    The serine–threonine kinase Akt regulates proliferation and survival by phosphorylating a network of protein substrates; however, the role of a negative regulator of the Akt pathway, the SH2-domain-containing inositol 5-phosphatase (SHIP2) in apoptosis of the hepatocytes, remains unknown. In the present study, we studied the molecular mechanisms linking SHIP2 expression to apoptosis using overexpression or suppression of SHIP2 gene in HepG2 cells exposed to palmitate (0.5 mM). Overexpression of the dominant negative mutant SHIP2 (SHIP2-DN) significantly reduced palmitate-induced apoptosis in HepG2 cells, as these cells had increased cell viability, decreased apoptotic cell death and reduced the activity of caspase-3, cytochrome c and poly (ADP-ribose) polymerase. Overexpression of the wild-type SHIP2 gene led to a massive apoptosis in HepG2 cells. The protection from palmitate-induced apoptosis by SHIP2 inhibition was accompanied by a decrease in the generation of reactive oxygen species (ROS). In addition, SHIP2 inhibition was accompanied by an increased Akt and FOXO-1 phosphorylation, whereas overexpression of the wild-type SHIP2 gene had the opposite effects. Taken together, these findings suggest that SHIP2 expression level is an important determinant of hepatic lipoapotosis and its inhibition can potentially be a target in treatment of hepatic lipoapoptosis in diabetic patients. - Highlights: • Lipoapoptosis is the major contributor to the development of NAFLD. • The PI3-K/Akt pathway regulates apoptosis in different cells. • The role of negative regulator of this pathway, SHIP2 in lipoapoptosis is unknown. • SHIP2 inhibition significantly reduces palmitate-induced apoptosis in HepG2 cells. • SHIP2 inhibition prevents palmitate induced-apoptosis by regulating Akt/FOXO1 pathway.

  5. A study of B(s)0 to J/psi phi in the D0 experiment and an example of HEP technology transfer

    SciTech Connect (OSTI)

    Bauer, Daniela Ursula

    2002-01-01

    After years of preparation, data taking with the upgraded D0 detector at the Tevatron proton-antiproton collider has begun. The large amount of data produced in a p{bar p}-collider requires sophisticated triggers to filter out the interesting events. Described in this thesis is the development of trigger software for the newly implemented Silicon Microstrip Tracker. D0 is a multi-purpose detector with a broad physics program. one area being studied at D0 is B mesons. An algorithm for reconstructing the B{sub s}{sup 0} and B{sub d}{sup 0} mesons and for measuring their lifetimes has been developed and is described in this thesis. The results suggest that an improvement of the current lifetime measurements can be achieved within the next two years. The reconstruction of a J/{psi} meson forms the basis for a wide range of b-physics. Data taken with the muon system during the commissioning period of the detector has been analyzed and a signal for the J/{psi} meson has been found. Systematic transfer of HEP technologies into other areas and their commercial exploitation plays an important role in the future of particle physics. An area of particular interest is DNA sequencing as shown by the recent completion of the sequencing of the human genome. The final part of this thesis details the development of a simulation for a high throughput sequencing device which is currently being developed at Imperial College.

  6. Biology and Medicine Division annual report, 1985

    SciTech Connect (OSTI)

    Not Available

    1986-04-01

    This book briefly describes the activities of the Biology and Medicine Division of the Lawrence Berkeley Laboratory. During the past year the Donner Pavilion program on the treatment of arteriovenous malformations in the brain has chalked up very significant successes. The disease control rate has been high and objective measures of success using cerebral angiography have been established. The new high resolution positron emitting tomographic imager has been demonstrated to operate successfully. In the Radiation Biophysics program, the availability of higher mass ions up to uranium has allowed us cell and tissue studies in a radiation domain that is entirely new. Using uranium beams, investigators have already made new and exciting findings that are described in the body of the report.

  7. Germanium detectors in homeland security at PNNL

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Stave, S.

    2015-05-01

    Neutron and gamma-ray detection is used for non-proliferation and national security applications. While lower energy resolution detectors such as NaI(Tl) have their place, high purity germanium (HPGe) also has a role to play. A detection with HPGe is often a characterization due to the very high energy resolution. However, HPGe crystals remain small and expensive leaving arrays of smaller crystals as an excellent solution. PNNL has developed two similar HPGe arrays for two very different applications. One array, the Multisensor Aerial Radiation Survey (MARS) detector is a fieldable array that has been tested on trucks, boats, and helicopters. The CASCADESmore » HPGe array is an array designed to assay samples in a low background environment. The history of HPGe arrays at PNNL and the development of MARS and CASCADES will be detailed in this paper along with some of the other applications of HPGe at PNNL.« less

  8. Reimbursable Work for Department of Homeland Security

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-04-21

    This revised Notice contains additional information and direction to cognizant DOE contracting officers and other affected Federal and contractor personnel identifying the processes and requirements to ensure the efficient implementation of the MOA. DOE N 251.62, dated 04-21-05, extends this directive until 4-21-06. Cancels DOE N 481.1.

  9. Germanium detectors in homeland security at PNNL

    SciTech Connect (OSTI)

    Stave, S.

    2015-05-01

    Neutron and gamma-ray detection is used for non-proliferation and national security applications. While lower energy resolution detectors such as NaI(Tl) have their place, high purity germanium (HPGe) also has a role to play. A detection with HPGe is often a characterization due to the very high energy resolution. However, HPGe crystals remain small and expensive leaving arrays of smaller crystals as an excellent solution. PNNL has developed two similar HPGe arrays for two very different applications. One array, the Multisensor Aerial Radiation Survey (MARS) detector is a fieldable array that has been tested on trucks, boats, and helicopters. The CASCADES HPGe array is an array designed to assay samples in a low background environment. The history of HPGe arrays at PNNL and the development of MARS and CASCADES will be detailed in this paper along with some of the other applications of HPGe at PNNL.

  10. Homeland Security and Emergency Management Coordination (HSEMC...

    National Nuclear Security Administration (NNSA)

    Program NNSA ensures that capabilities are in place to respond to any NNSA and Department of Energy facility emergency. It is also the nation's premier responder to any nuclear ...

  11. NAMP Participates in Homeland Security Exercise

    Broader source: Energy.gov [DOE]

    CARLSBAD, N.M. – A program led by EM’s Carlsbad Field Office (CBFO) that coordinates analytical capabilities throughout DOE for response to potential national radiological incidents participated in a multi-agency exercise that simulated emergency response scenarios in Denver and Chicago.

  12. Department of Homeland Security's Science & Technology Directorate...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Five of those technologies - Quantum Secured Communication, Hyperion, NeMS, PathScan and now PACRAT have successfully transitioned to the marketplace through commercial licenses. ...

  13. New Mexico Center for Isotopes in Medicine

    SciTech Connect (OSTI)

    Burchiel, Scott W.

    2012-12-13

    The purpose of the New Mexico Center for Isotopes in Medicine (NMCIM) is to support research, education and service missions of the UNM College of Pharmacy Radiopharmaceutical Sciences Program (COP RSP) and the Cancer Research and Treatment Center (CRTC). NMCIM developed and coordinated unique translational research in cancer radioimaging and radiotherapy agents based on novel molecules developed at UNM and elsewhere. NMCIM was the primary interface for novel radioisotopes and radiochemistries developed at the Los Alamos National Laboratory (LANL) for SPECT/PET imaging and therapy. NMCIM coordinated the use of the small animal imaging facility with the CRTC provided support services to assist investigators in their studies. NMCIM developed education and training programs that benefited professional, graduate, and postdoctoral students that utilized its unique facilities and technologies. UNM COP RSP has been active in writing research and training grants, as well as supporting contract research with industrial partners. The ultimate goal of NMCIM is to bring new radiopharmaceutical imaging and therapeutic agents into clinical trials that will benefit the health and well being of cancer and other patients in New Mexico and the U.S.

  14. Pathways, Networks and Systems Medicine Conferences

    SciTech Connect (OSTI)

    Nadeau, Joseph H.

    2013-11-25

    The 6th Pathways, Networks and Systems Medicine Conference was held at the Minoa Palace Conference Center, Chania, Crete, Greece (16-21 June 2008). The Organizing Committee was composed of Joe Nadeau (CWRU, Cleveland), Rudi Balling (German Research Centre, Brauschweig), David Galas (Institute for Systems Biology, Seattle), Lee Hood (Institute for Systems Biology, Seattle), Diane Isonaka (Seattle), Fotis Kafatos (Imperial College, London), John Lambris (Univ. Pennsylvania, Philadelphia),Harris Lewin (Univ. of Indiana, Urbana-Champaign), Edison Liu (Genome Institute of Singapore, Singapore), and Shankar Subramaniam (Univ. California, San Diego). A total of 101 individuals from 21 countries participated in the conference: USA (48), Canada (5), France (5), Austria (4), Germany (3), Italy (3), UK (3), Greece (2), New Zealand (2), Singapore (2), Argentina (1), Australia (1), Cuba (1), Denmark (1), Japan (1), Mexico (1), Netherlands (1), Spain (1), Sweden (1), Switzerland (1). With respect to speakers, 29 were established faculty members and 13 were graduate students or postdoctoral fellows. With respect to gender representation, among speakers, 13 were female and 28 were male, and among all participants 43 were female and 58 were male. Program these included the following topics: Cancer Pathways and Networks (Day 1), Metabolic Disease Networks (Day 2), Day 3 ? Organs, Pathways and Stem Cells (Day 3), and Day 4 ? Inflammation, Immunity, Microbes and the Environment (Day 4). Proceedings of the Conference were not published.

  15. Optical fibers in medicine II: SPIE volume 713

    SciTech Connect (OSTI)

    Katzir, A.

    1987-01-01

    The papers are organized under the following titles: Therapeutic applications of optical fibers; Optical fibers in cardiology, Imaging and diagnostics; Selected readings in optical fibers in medicine; and Manufacturers of laser and fiber optic equipment for medical applications.

  16. Science on Tap - Why Los Alamos produces isotopes for medicine...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science on Tap - Why Los Alamos produces isotopes for medicine and industry At the Bradbury Latest Issue:June 2016 all issues All Issues submit Science on Tap - Why Los Alamos ...

  17. Medicine Lake, Minnesota: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    Hide Map This article is a stub. You can help OpenEI by expanding it. Medicine Lake is a city in Hennepin County, Minnesota. It falls under Minnesota's 3rd...

  18. Biology and Medicine Division annual report, 1982-1983

    SciTech Connect (OSTI)

    Not Available

    1984-04-01

    This annual report presents brief summaries of research activities during 1982 to 1983. Program activities have been individually entered into EDB. They include research medicine, radiosurgery, environmental physiology, radiation biophysics, and structural biophysics. (ACR)

  19. March 2015 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    5 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. Brookhaven National Lab., Upton, NY (United States)|State ...

  20. Converting energy to medical progress [nuclear medicine] (Technical Report)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | SciTech Connect Converting energy to medical progress [nuclear medicine] Citation Details In-Document Search Title: Converting energy to medical progress [nuclear medicine] × You are accessing a document from the Department of Energy's (DOE) SciTech Connect. This site is a product of DOE's Office of Scientific and Technical Information (OSTI) and is provided as a public service. Visit OSTI to utilize additional information resources in energy science and technology. A paper copy of this

  1. COMP-1h.EPS

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Ballpoint pens Bandages Beach umbrellas Boats Cameras Candles Candies and gum Car battery cases Car enamel Cassettes Caulking CDscomputer disks Cellular phones Clothesline Coffee ...

  2. COMP-1h.EPS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tents Tires Toilet seats Tool boxes Tool racks Toothbrushes Toothpaste Transparent tape Trash bags TV cabinets Umbrellas Unbreakable dishes Upholstery Vaporizers Vinyl flooring...

  3. HEP-Req_SLAC.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laboratory Large Scale Computing and Storage Requirements for High Energy Physics NERSCASCRHEP Workshop, Washington D.C., November 12-13, 2009 NERSC Project * Project ...

  4. IntroHEP-compressed.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ASCR Facility Plans --- 1 --- June 1 0, 2 015 Projections on Moore's Law and other trends Figure c ourtesy o f Kunle O lukotun, Lance H ammond, H erb S u=er, a nd Burton S mith, 2 004 2 0 1 10 100 1000 10000 100000 1000000 10000000 1970 1975 1980 1985 1990 1995 2000 2005 2010 Transistors (Thousands) Frequency (MHz) Power (W) Cores 1.E+01 1.E+02 1.E+03 1.E+04 1.E+05 1.E+06 1.E+07 1/1/1992 1/1/1996 1/1/2000 1/1/2004 1/1/2008 1/1/2012 1/1/2016 1/1/2020 1/1/2024 Energy per Flop (pJ) Heavyweight

  5. Physics in medicine and biology encyclopedia 2-volume set

    SciTech Connect (OSTI)

    McAinsh, T.F.

    1986-01-01

    The Physics in Medicine and Biology Encyclopedia provides in two volumes a review of a wide range of topics of current interest in medical physics, bioengineering and biophysics. The Encyclopedia is extensively cross-referenced, indexed and illustrated, and all articles are complete with fully verified bibliographies. A glossary gives full details of specialized terms appearing in the Encyclopedia.

  6. Determination of elements in ayurvedic medicinal plants by AAS

    SciTech Connect (OSTI)

    Teerthe, Santoshkumar S.; Kerur, B. R.

    2015-08-28

    India has a rich country for the uses of Ayurvedic medicinal plants for treatment and also the north- Karnataka boasts an unparallel diversity of medicinal plants. The present study attempts to estimate and compare the level of trace and heavy metals in some selected leaves and root samples of Ayurvedic medicinal plants such as Mg, Al, K, Cr, Mn, Fe, Cu, Zn, and Cd. The samples are collected from different places of North-Karnataka regions and sample solutions prepared as the ratio of 1:25:25+950ml=1000ppm.the trace and heavy elemental concentration was estimated using Atomic Absorption Spectrometric (AAS) Method. The average concentrations of Mg, Mn, Fe and Zn, are ranging from 2ppm to 5250.2ppm and potassium (K) has more concentration as compare to all other. The other elements likes Al, Cr, Cu, and Cd were also estimed and presented in the table. Therefore, these medicinal plants are rich in some essential minerals, especially K, Mg, Mn, Fe and Zn which are essential for human health.

  7. Dictionary/handbook of nuclear medicine and clinical imaging

    SciTech Connect (OSTI)

    Iturralde, M.P. )

    1989-01-01

    This book covers the following topics: Fundamentals of English medical etymology, Abbreviations, acronyms, symbols, denotations, and signs commonly used or defined in the dictionary, Characteristics of the elements, Characteristics of practicable radioisotopes and of selected radionuclides commonly used in nuclear medicine, Properties and production of radionuclides, Radioactive decay, Radiopharmaceuticals, and Radiation dosimetry.

  8. EIS-0432: Medicine Bow Fuel & Power Coal-to-Liquid Facility in...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2: Medicine Bow Fuel & Power Coal-to-Liquid Facility in Carbon County, WY EIS-0432: Medicine Bow Fuel & Power Coal-to-Liquid Facility in Carbon County, WY Documents Available for ...

  9. ORISE: Advanced Radiation Medicine | REAC/TS Continuing Medical Education

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Course Advanced Radiation Medicine Dates Scheduled Register Online April 24-28, 2017 August 14-18, 2017 Fee: $275 Maximum enrollment: 28 30 hours AMA PRA Category 1 Credits(tm) This 4½-day course includes more advanced information for medical practitioners. This program is academically more rigorous than the REM course and is primarily for Physicians, Physician Assistants, Nurse Practitioners, and Nurses desiring an advanced level of information on the diagnosis and management of ionizing

  10. Assessment of OEP health's risk in nuclear medicine

    SciTech Connect (OSTI)

    Santacruz-Gomez, K.; Manzano, C.; Melendrez, R.; Castaneda, B.; Barboza-Flores, M.; Pedroza-Montero, M.

    2012-10-23

    The use of ionizing radiation has been increased in recent years within medical applications. Nuclear Medicine Department offers both treatment and diagnosis of diseases using radioisotopes to controlled doses. Despite the great benefits to the patient, there is an inherent risk to workers which remains in contact with radiation sources for long periods. These personnel must be monitored to avoid deterministic effects. In this work, we retrospectively evaluated occupationally exposed personnel (OEP) to ionizing radiation in nuclear medicine during the last five years. We assessed both area and personal dosimetry of this department in a known Clinic in Sonora. Our results show an annual equivalent dose average of 4.49 {+-} 0.70 mSv in OEP without showing alarming changes in clinical parameters analyzed. These results allow us to conclude that health of OEP in nuclear medicine of this clinic has not been at risk during the evaluated period. However, we may suggest the use of individual profiles based on specific radiosensitivity markers.

  11. ORISE: Radiation Emergency Medicine | REAC/TS Continuing Medical Education

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Course Radiation Emergency Medicine Dates Scheduled Register Online October 11-14, 2016 February 7-10, 2017 February 28 - March 3, 2017 April 18-21, 2017 June 13-16, 2017 August 8-11, 2017 Fee: $200 Maximum enrollment: 22 24.5 hours AMA PRA Category 1 Credits(tm) This 3½-day course is intended for Physicians, Physician Assistants, Nurse Practitioners, Nurses and other healthcare providers. First responders, emergency management, and public health professionals may find the course

  12. Core Analysis At Medicine Lake Area (Clausen Et Al, 2006) | Open...

    Open Energy Info (EERE)

    Lisle, 1995; Nemcok and Gayer, 1996). References Steven Clausen, Michal Nemcok, Joseph Moore, Jeffrey Hulen, John Bartley (2006) Mapping Fractures In The Medicine Lake Geothermal...

  13. Flexible nuclear medicine camera and method of using

    DOE Patents [OSTI]

    Dilmanian, F.A.; Packer, S.; Slatkin, D.N.

    1996-12-10

    A nuclear medicine camera and method of use photographically record radioactive decay particles emitted from a source, for example a small, previously undetectable breast cancer, inside a patient. The camera includes a flexible frame containing a window, a photographic film, and a scintillation screen, with or without a gamma-ray collimator. The frame flexes for following the contour of the examination site on the patient, with the window being disposed in substantially abutting contact with the skin of the patient for reducing the distance between the film and the radiation source inside the patient. The frame is removably affixed to the patient at the examination site for allowing the patient mobility to wear the frame for a predetermined exposure time period. The exposure time may be several days for obtaining early qualitative detection of small malignant neoplasms. 11 figs.

  14. Flexible nuclear medicine camera and method of using

    DOE Patents [OSTI]

    Dilmanian, F. Avraham; Packer, Samuel; Slatkin, Daniel N.

    1996-12-10

    A nuclear medicine camera 10 and method of use photographically record radioactive decay particles emitted from a source, for example a small, previously undetectable breast cancer, inside a patient. The camera 10 includes a flexible frame 20 containing a window 22, a photographic film 24, and a scintillation screen 26, with or without a gamma-ray collimator 34. The frame 20 flexes for following the contour of the examination site on the patient, with the window 22 being disposed in substantially abutting contact with the skin of the patient for reducing the distance between the film 24 and the radiation source inside the patient. The frame 20 is removably affixed to the patient at the examination site for allowing the patient mobility to wear the frame 20 for a predetermined exposure time period. The exposure time may be several days for obtaining early qualitative detection of small malignant neoplasms.

  15. Textbook of clinical occupational and environmental medicine. 2nd ed.

    SciTech Connect (OSTI)

    Rosenstock, L.; Cullen, M.; Brodkin, C.; Redlich, C.

    2004-12-15

    Comprehensive and updated throughout, this new edition makes it easy to detect, diagnose, and treat the full spectrum of problems caused by occupational or environmental factors, including physical, chemical, and biologic agents. An international cast of experts offers in-depth, authoritative guidance on clinical problems as well as the legal and regulatory issues impacting the practice of occupational and environmental medicine today. Section 1 is on principles and practice. Section 2 on work sectors and special populations includes a chapter on mining. Section 3 on occupational diseases and injuries includes several chapters of relevance to the coal mining industry, including diseases of the lung and pleura covering silicosis, respiratory diseases of coal miners, and malignancies of the respiratory tract and pleura. Section 4 on hazards in the workplace and the environment includes a chapter on mineral dusts. Section 5 covers policy, regulation and control.

  16. Biology and Medicine Division annual report, 1981-1982. [Lead abstract

    SciTech Connect (OSTI)

    Not Available

    1983-04-01

    Separate abstracts were prepared for the 61 research reports in the 1981-1982 annual report for the Biology and Medicine Division of the Lawrence Berkeley Laboratory. Programs reviewed include research medicine, Donner Pavilion, environmental physiology, radiation biophysics and structural biophysics. (KRM)

  17. Ernest Orlando Lawrence (1901-1958), Cyclotron and Medicine

    SciTech Connect (OSTI)

    Chu, William T.

    2005-09-01

    On August 8, 2001, Lawrence Berkeley National Laboratory celebrated the centennial of the birth of its founder (and namesake), Ernest Orlando Lawrence. For the occasion, many speeches were given and old speeches were remembered. We recall the words of the late Luis Alvarez, a Nobel Laureate and one of the Lawrence's closest colleagues: ''Lawrence will always be remembered as the inventor of the cyclotron, but more importantly, he should be remembered as the inventor of the modern way of doing science''. J. L. Heilbron and R. W. Seidel, in the introduction of their book, ''Lawrence and His Laboratory'' stated, ''The motives and mechanisms that shaped the growth of the Laboratory helped to force deep changes in the scientific estate and in the wider society. In the entrepreneurship of its founder, Ernest Orlando Lawrence, these motives, mechanisms, and changes came together in a tight focus. He mobilized great and small philanthropists, state and local governments, corporations, and plutocrats, volunteers and virtuosos. The work they supported, from astrophysics and atomic bombs, from radiochemistry to nuclear medicine, shaped the way we observe, control, and manipulate our environment.'' Indeed, all over the civilized world, the ways we do science changed forever after Lawrence built his famed Radiation Laboratory. In this editorial, we epitomize his legacy of changing the way we do medicine, thereby affecting the health and well being of all humanity. This year marks the 75th anniversary of the invention of the cyclotron by Ernest Orlando Lawrence at the University of California at Berkeley. Lawrence conceived the idea of the cyclotron early in 1929 after reading an article by Rolf Wideroe on high-energy accelerators. In the spring of 1930 one of his students, Nels Edlefsen, constructed two crude models of a cyclotron. Later in the fall of the same year, another student, M. Stanley Livingston, constructed a 13-cm diameter model that had all the features of early

  18. STRUCTURAL BIOLOGY AND MOLECULAR MEDICINE RESEARCH PROGRAM (LSBMM)

    SciTech Connect (OSTI)

    Eisenberg, David S.

    2008-07-15

    The UCLA-DOE Institute of Genomics and Proteomics is an organized research unit of the University of California, sponsored by the Department of Energy through the mechanism of a Cooperative Agreement. Today the Institute consists of 10 Principal Investigators and 7 Associate Members, developing and applying technologies to promote the biological and environmental missions of the Department of Energy, and 5 Core Technology Centers to sustain this work. The focus is on understanding genomes, pathways and molecular machines in organisms of interest to DOE, with special emphasis on developing enabling technologies. Since it was founded in 1947, the UCLA-DOE Institute has adapted its mission to the research needs of DOE and its progenitor agencies as these research needs have changed. The Institute started as the AEC Laboratory of Nuclear Medicine, directed by Stafford Warren, who later became the founding Dean of the UCLA School of Medicine. In this sense, the entire UCLA medical center grew out of the precursor of our Institute. In 1963, the mission of the Institute was expanded into environmental studies by Director Ray Lunt. I became the third director in 1993, and in close consultation with David Galas and John Wooley of DOE, shifted the mission of the Institute towards genomics and proteomics. Since 1993, the Principal Investigators and Core Technology Centers are entirely new, and the Institute has separated from its former division concerned with PET imaging. The UCLA-DOE Institute shares the space of Boyer Hall with the Molecular Biology Institute, and assumes responsibility for the operation of the main core facilities. Fig. 1 gives the organizational chart of the Institute. Some of the benefits to the public of research carried out at the UCLA-DOE Institute include the following: The development of publicly accessible, web-based databases, including the Database of Protein Interactions, and the ProLinks database of genomicly inferred protein function linkages

  19. EIS-0432: Medicine Bow Fuel & Power Coal-to-Liquid Facility in Carbon

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    County, WY | Department of Energy 2: Medicine Bow Fuel & Power Coal-to-Liquid Facility in Carbon County, WY EIS-0432: Medicine Bow Fuel & Power Coal-to-Liquid Facility in Carbon County, WY Documents Available for Download November 27, 2009 EIS-0432: Notice of Intent to Prepare an Environmental Impact Statement Federal Loan Guarantee to Support the Construction and Startup of the Medicine Bow Fuel & Power Coal-to-Liquid Facility in Carbon County, Wyoming December 16, 2009

  20. National Atmospheric Release Advisory Center (NARAC) Capabilities for Homeland Security

    SciTech Connect (OSTI)

    Sugiyama, G; Nasstrom, J; Baskett, R; Simpson, M

    2010-03-08

    The Department of Energy's National Atmospheric Release Advisory Center (NARAC) provides critical information during hazardous airborne releases as part of an integrated national preparedness and response strategy. Located at Lawrence Livermore National Laboratory, NARAC provides 24/7 tools and expert services to map the spread of hazardous material accidentally or intentionally released into the atmosphere. NARAC graphical products show affected areas and populations, potential casualties, and health effect or protective action guideline levels. LLNL experts produce quality-assured analyses based on field data to assist decision makers and responders. NARAC staff and collaborators conduct research and development into new science, tools, capabilities, and technologies in strategically important areas related to airborne transport and fate modeling and emergency response. This paper provides a brief overview of some of NARAC's activities, capabilities, and research and development.

  1. Phase Contrast X-ray Imaging Signatures for Homeland Security...

    Office of Scientific and Technical Information (OSTI)

    We investigate the length scales to which our imaging system is sensitive. Authors: Miller, Erin A. ; White, Timothy A. ; McDonald, Benjamin S. ; Seifert, Allen ; Flynn, Michael J. ...

  2. PNNLs Data Intensive Computing research battles Homeland Security threats

    ScienceCinema (OSTI)

    David Thurman; Joe Kielman; Katherine Wolf; David Atkinson

    2012-12-31

    The Pacific Northwest National Laboratorys (PNNL's) approach to data intensive computing (DIC) is focused on three key research areas: hybrid hardware architecture, software architectures, and analytic algorithms. Advancements in these areas will help to address, and solve, DIC issues associated with capturing, managing, analyzing and understanding, in near real time, data at volumes and rates that push the frontiers of current technologies.

  3. Homeland Security Presidential Directive HSPD-7 (December 17, 2003)

    Office of Energy Efficiency and Renewable Energy (EERE)

    This directive establishes a national policy for Federal departments and agencies to identify and prioritize United States critical infrastructure and key resources and to protect them from...

  4. Monte Carlo Simulations for Homeland Security Using Anthropomorphic Phantoms

    SciTech Connect (OSTI)

    Burns, Kimberly A.

    2008-01-01

    A radiological dispersion device (RDD) is a device which deliberately releases radioactive material for the purpose of causing terror or harm. In the event that a dirty bomb is detonated, there may be airborne radioactive material that can be inhaled as well as settle on an individuals leading to external contamination.

  5. How ORISE is Making a Difference: Homeland Security

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    In order to do that, experts from a wide-range of disciplines-such as cyber security, border security, or even airline security-must work together for the prevention of...

  6. Homeland Security Science, Technology, Engineering, Mathematics Career Development Program Report

    SciTech Connect (OSTI)

    Bryson, Kathleen H.

    2009-11-06

    Report including the background, reserach and recommendations to expand the current DHS HS-STEM Career Development Program.

  7. Before the Senate Homeland Security and Governmental Affairs...

    Energy Savers [EERE]

    Office of Procurement and Assistance Management, Office of Management Subject: Cost-Plus Award Fee PDF icon 8-3-09FinalTestimony(Simpson).pdf More Documents & Publications...

  8. Before the Senate Homeland Security and Governmental Affairs...

    Broader source: Energy.gov (indexed) [DOE]

    and International Security By: Richard Kidd, Program Manager Federal Energy Management Program, Office of Energy Efficiency and Renewable Energy Subject: Cutting the Federal...

  9. Homeland Security | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    developed by high energy physicists to study the characteristics of neutrinos and antineutrinos, as a demonstration of a new monitoring technology for nuclear nonproliferation. ...

  10. Nuclear Medicine at Berkeley Lab: From Pioneering Beginnings to Today (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Budinger, Thomas [LBNL, Center for Functional Imaging

    2011-10-04

    Summer Lecture Series 2006: Thomas Budinger, head of Berkeley Lab's Center for Functional Imaging, discusses Berkeley Lab's rich history pioneering the field of nuclear medicine, from radioisotopes to medical imaging.

  11. Structure of Chinese Herbal-based Medicine Captured by ATP on...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structure of Chinese Herbal-based Medicine Captured by ATP on a Human tRNA Synthetase ... The structure of this co-crystal is the first for human ProRS. However, most ...

  12. Cancer Research Center Indiana University School of Medicine

    SciTech Connect (OSTI)

    Not Available

    1994-08-01

    The Department of Energy (DOE) proposes to authorize the Indiana School of Medicine to proceed with the detailed design, construction and equipping of the proposed Cancer Research Center (CRC). A grant was executed with the University on April 21, 1992. A four-story building with basement would be constructed on the proposed site over a 24-month period. The proposed project would bring together, in one building, three existing hematology/oncology basic research programs, with improved cost-effectiveness through the sharing of common resources. The proposed site is currently covered with asphaltic pavement and is used as a campus parking lot. The surrounding area is developed campus, characterized by buildings, walkways, with minimal lawns and plantings. The proposed site has no history of prior structures and no evidence of potential sources of prior contamination of the soil. Environmental impacts of construction would be limited to minor increases in traffic, and the typical noises associated with standard building construction. The proposed CRC project operation would involve the use radionuclides and various hazardous materials in conducting clinical studies. Storage, removal and disposal of hazardous wastes would be managed under existing University programs that comply with federal and state requirements. Radiological safety programs would be governed by Nuclear Regulatory Commission (NRC) license and applicable Environmental Protection Agency (EPA) regulations. There are no other NEPA reviews currently active which are in relationship to this proposed site. The proposed project is part of a Medical Campus master plan and is consistent with applicable local zoning and land use requirements.

  13. 2015 DOE Annual Occupational Medicine Workshop & Webinar (OMWW)- March 16-17, 2015

    Broader source: Energy.gov [DOE]

    The 2015 DOE Annual Occupational Medicine Workshop & Webinar (OMWW) is a valuable training opportunity established by the Office of Health, Safety, and Security in support of hundreds of medical, allied health professionals, and subject matter experts from over four dozen locations across the Department. Their vital work in the field of Occupational Medicine encompasses medical qualification examinations, injury and illness management, disability management, workers’ compensation, and much more.

  14. Symposium on Data Preservation in HEP

    ScienceCinema (OSTI)

    None

    2011-10-06

    1. A view point on data preservation in High Energy Physics by Rolf Heuer 2. Results from the PARSE.Insight project by Salvatore Mele 3. The ICFA-DPHEP study group by Cristinel Diaconu 4. Discussion

  15. FES BER HEP NP BES ASCR

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    December 2015 NERSC Science Highlights Science Highlights December 2015 Chemistry Simula'ons run at NERSC lead to the predic'on of a new phase of superionic ice, a special form of ice that could exist on Uranus and Neptune (Roberto Car , Princeton U., Nature Comm.) Fusion Energy 3D simula'ons run at NERSC help gain new insights into fusion plasma behavior that will improve the ability to stabilize a tokamak reactor (S. Jardin , Princeton Plasma Physics Lab, Phys. Rev. Lett.) High Energy &

  16. FES BER HEP NP BES ASCR

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    September 2015 NERSC Science Highlights NERSC Science Highlights September 2015 Fusion Energy 3D simula*ons yield new insights into why plasma in a Tokamak fusion reactor fails to reach required temperatures (R. Davidson/E. Belova , PPPL) Renewable Energy Ensemble simula*ons of flow through geothermal fracture networks improve reliability & economics of renewable geothermal energy. (Melior Innovations Inc.) Geophysics 3D scan of Earth's interior connects plumes of hot rock rising through the

  17. HEP/NP Requirements Review 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NP Program Offices. These requirements will serve as input to the ESnet architecture and planning processes, and will help ensure that ESnet continues to provide world-class...

  18. Microsoft Word - HEP2017_FINAL.docx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2012 Large Scale Computing and Storage Requirements for High Energy Physics: Target 2017 2 DISCLAIMER ... and data tools, as well as a system of distributed computing worldwide. ...

  19. Microsoft Word - HEP2017_FINAL.docx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Large Scale Computing and Storage Requirements for High Energy Physics: Target 2017 2 DISCLAIMER This ... and data tools, as well as a system of distributed computing worldwide. ...

  20. HEP-NUG-WS-forcray.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEPNERSCASCR Requirements Workshop Large Scale Computing and Storage Requirements for High Energy Physics NERSC Lawrence Berkeley National Laboratory Workshop Held Nov 12-13, ...

  1. nersc-for-hep-theory.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ph.D.! NERSC User Services High Performance Computing and Big Data at NERSC --- 1 --- April 3 , 2 013 Outline * What i s N ERSC? * Who r uns a t N ERSC? * Can y ou u se/do y ou n eed H igh P erformance CompuDng a nd D ata S ervices? --- 2 --- What is NERSC? --- 3 --- NERSC is the High Performance Production Computing Center for the DOE Office of Science 4 NERSC's f ocus i s o n e nabling s cienDfic producDvity * 1,500 r efereed p ublica1ons p er y ear * ~10 m ajor j ournal c overs p er y ear *

  2. Fermilab at Work | Physics Links: HEP Labs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Linear Accelerator Center LNS at Cornell University CERN (Geneva, Switzerland) DESY (Hamburg, Germany) KEK (Tsukuba, Japan) JINR (Dubna, Russia) JLab ANL (High Energy Physics) LBL...

  3. Development of taste sensor system for differentiation of Indonesian herbal medicines

    SciTech Connect (OSTI)

    Kaltsum, U.; Triyana, K. Siswanta, D.

    2014-09-25

    In Indonesia, herbal medicines are usually produced by small and medium enterprises which are relatively low in quality control. The purpose of this paper is to report that we have developed a taste sensor system with global selectivity, i.e., electronic tongue (e-tongue) for differentiation of Indonesian herbal medicines. The e-tongue was composed of five kinds of ion selective electrodes as working electrodes, data acquisition system, and pattern recognition system. Each ion selective electrode (ISE) was built by attaching lipid/polymer membrane. For this purpose, the five kinds of membranes were built by mixing lipid, plasticizer (nitrophenyl octyl ether/NPOE), polyvinyl chloride (PVC), and tetrahydrofuran (THF). In this study, we employed five kinds of lipid, namely oleic acid (OA), dioctyl phosphate (DOP), decyl alcohol (DA), dodecylamine (DDC), and trioctyl methyl ammonium chloride (TOMA). In this case, the membranes transform information of taste substances into electric signal. The five kinds of Indonesian herbal medicine were purchased from local supermarket in Yogyakarta, i.e., kunyit asam (made from turmeric and tamarind), beras kencur (made from rice and kencur), jahe wangi (made from ginger and fragrance), sirih wangi (made from betel leaf), and temulawak (made from Javanese ginger). Prior to detecting the taste from the Indonesian herbal medicine samples, each ion selective electrode was tested with five basic taste samples, i.e., for saltiness, sweetness, umami, bitterness, and sourness. All ISEs showed global selectivity to all samples. Furthermore, the array of ISEs showed specific response pattern to each Indonesian herbal medicine. For pattern recognition system, we employed principle component analysis (PCA). As a result, the e-tongue was able to differentiate five kinds of Indonesian herbal medicines, proven by the total variance of first and second principle components is about 93%. For the future, the e-tongue may be developed for quality

  4. Interdisciplinary Dialogue for Education, Collaboration, and Innovation: Intelligent Biology and Medicine In and Beyond 2013

    SciTech Connect (OSTI)

    Zhang, Bing; Huang, Yufei; McDermott, Jason E.; Posey, Rebecca H.; Xu, Hua; Zhao, Zhongming

    2013-12-09

    The 2013 International Conference on Intelligent Biology and Medicine (ICIBM 2013) was held on August 11-13, 2013 in Nashville, Tennessee, USA. The conference included six scientific sessions, two tutorial sessions, one workshop, two poster sessions, and four keynote presentations that covered cutting-edge research topics in bioinformatics, systems biology, computational medicine, and intelligent computing. Here, we present a summary of the conference and an editorial report of the supplements to BMC Genomics and BMC Systems Biology that include 19 research papers selected from ICIBM 2013.

  5. HIV/AIDS Information Resources from the National Library of Medicine-STOP

    SciTech Connect (OSTI)

    Templin-Branner, W. and N. Dancy

    2010-06-15

    The HIV/AIDS Information Resources from the National Library of Medicine training is designed specifically for the UNCFSP HBCU Screening, Testing, Outreach, and Prevention (STOP) HIV/AIDS Program project members to provide valuable health information resources from the National Library of Medicine and other reliable sources to increase awareness of the wealth of treatment information and educational materials that are available on the Internet and to improve prevention and treatment education for their clients. These resources will also meet the needs of community-based organizations

  6. DOE - Office of Legacy Management -- Long Island College of Medicine - NY

    Office of Legacy Management (LM)

    0-14 Long Island College of Medicine - NY 0-14 FUSRAP Considered Sites Site: Long Island College of Medicine (NY.0-14 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: New York , New York NY.0-14-1 Evaluation Year: 1987 NY.0-14-1 Site Operations: Performed research utilizing small quantities of radioactive materials in a controlled environment. NY.0-14-1 Site Disposition: Eliminated - Potential for contamination remote NY.0-14-1

  7. Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines

    SciTech Connect (OSTI)

    Brandon, Esther F.A.; Bosch, Tessa M.; Deenen, Maarten J.; Levink, Rianne; Wal, Everdina van der; Meerveld, Joyce B.M. van; Bijl, Monique; Beijnen, Jos H. |; Schellens, Jan H.M. |; Meijerman, Irma . E-mail: I.Meijerman@pharm.uu.nl

    2006-02-15

    Human cell lines are often used for in vitro biotransformation and transport studies of drugs. In vivo, genetic polymorphisms have been identified in drug-metabolizing enzymes and ABC-drug transporters leading to altered enzyme activity, or a change in the inducibility of these enzymes. These genetic polymorphisms could also influence the outcome of studies using human cell lines. Therefore, the aim of our study was to pharmacogenotype four cell lines frequently used in drug metabolism and transport studies, HepG2, IGROV-1, CaCo-2 and LS180, for genetic polymorphisms in biotransformation enzymes and drug transporters. The results indicate that, despite the presence of some genetic polymorphisms, no real effects influencing the activity of metabolizing enzymes or drug transporters in the investigated cell lines are expected. However, this characterization will be an aid in the interpretation of the results of biotransformation and transport studies using these in vitro cell models.

  8. Structure of Chinese Herbal-based Medicine Captured by ATP on a Human tRNA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Synthetase | Stanford Synchrotron Radiation Lightsource Structure of Chinese Herbal-based Medicine Captured by ATP on a Human tRNA Synthetase Thursday, October 31, 2013 For thousands of years the Chinese have been using the Chang Shan herb (Dichroa febrifuga Lour) to treat malaria-induced fevers (1). The active ingredient in the herb was eventually shown to be a small molecule known as febrifugine. A halogenated derivative of febrifugine, called halofuginone (HF), has been tested in clinical

  9. Diagnostic and therapeutic applications of diode lasers and solid state lasers in medicine. Progress report

    SciTech Connect (OSTI)

    Jacques, S.L.; Welch, A.J.; Motamedi, M.; Rastegar, S.; Tittel, F.; Esterowitz, L.

    1993-05-01

    The Texas Medical Center in Houston and the nearby UT Medical Branch at Galveston together constitute a major center of medical research activities. Laser applications in medicine are under development with the engineering assistance of the collaborating engineering enters at Rice University, UT-Austin, Texas A&M Univ. In addition, this collective is collaborating with the naval Research Laboratory, where new developments in laser design are underway, in order to transfer promising new laser technology rapidly into the medical environment.

  10. TOXNET and Beyond: Using the National Library of Medicine's Environmental Health and Toxicology Portal

    SciTech Connect (OSTI)

    Templin-Branner, W.

    2010-10-20

    The National Library of Medicine's Environmental Health and Toxicology Portal provides access to numerous databases that can help you explore environmental chemicals and risks. TOXNET and Beyond: Using NLM's Environmental Health and Toxicology Portal conveys the fundamentals of searching the NLM's TOXNET system of databases in chemistry, toxicology, environmental health, and related fields. In addition to TOXNET, the course will highlight various resources available through the Environmental Health and Toxicology Portal.

  11. September 2013 Most Viewed Documents for Biology And Medicine | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy Office of Scientific and Technical Information September 2013 Most Viewed Documents for Biology And Medicine Drug Retention Times Center for Human Reliability Studies (2007) 29 Oleoresin Capsicum toxicology evaluation and hazard review Archuleta, M.M. (1995) 27 SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE GENERATOR SETS. KRISHNA,C.R. (1999) 27 Site-Directed Research and Development FY 2012 Annual Report , (2013) 27 Human radiation studies: Remembering the early years. Oral

  12. September 2015 Most Viewed Documents for Biology And Medicine | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy Office of Scientific and Technical Information September 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. [Brookhaven National Lab., Upton, NY (United States)]|[State Univ. of New York at Stony Brook, Stony Brook, NY (United States). Dept. of Psychiatry]; Fowler, J.S.; Logan, J.; Wang, G.J. [Brookhaven National Lab., Upton, NY (United States)] (1995) 168 Drug Retention Times Center for Human Reliability

  13. Diagnostic and therapeutic applications of diode lasers and solid state lasers in medicine

    SciTech Connect (OSTI)

    Jacques, S.L. . Cancer Center); Welch, A.J. ); Motamedi, M. . Medical Branch); Rastegar, S. ); Tittel, F. ); Esterowitz, L. )

    1992-05-01

    The Texas Medical Center in Houston and the nearby UT Medical Branch at Galveston together constitute a major center of medical research activities. Laser applications in medicine are under development with the engineering assistance of the colloborating engineering centers at Rice University, UT-Austin, and Texas A M Univ. In addition, this collective is collaborating with the Naval Research Laboratory, where new developments in laser design are underway, in order to transfer promising new laser technology rapidly into the medical environment.

  14. Software optimized on Mira advances design of mini-proteins for medicines,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    materials | Argonne National Laboratory Software optimized on Mira advances design of mini-proteins for medicines, materials By Katie Elyce Jones * February 12, 2016 Tweet EmailPrint When diseases like cancer and AIDS affect millions of people each year and rare but deadly infections like Ebola move faster than treatment, the race to make effective drugs becomes a sprint. That's why University of Washington (UW) researchers are using one of the nation's most powerful supercomputers, the

  15. April 2013 Most Viewed Documents for Biology And Medicine | OSTI, US Dept

    Office of Scientific and Technical Information (OSTI)

    of Energy Office of Scientific and Technical Information April 2013 Most Viewed Documents for Biology And Medicine Publications in biomedical and environmental sciences programs, 1981 Moody, J.B. (comp.) (1982) 306 Drug Retention Times Center for Human Reliability Studies (2007) 99 SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE GENERATOR SETS. KRISHNA,C.R. (1999) 95 Defining the Effectiveness of UV Lamps Installed in Circulating Air Ductwork Douglas VanOsdell; Karin Foarde (2002) 84

  16. December 2015 Most Viewed Documents for Biology And Medicine | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy Office of Scientific and Technical Information December 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. [Brookhaven National Lab., Upton, NY (United States)]|[State Univ. of New York at Stony Brook, Stony Brook, NY (United States). Dept. of Psychiatry]; Fowler, J.S.; Logan, J.; Wang, G.J. [Brookhaven National Lab., Upton, NY (United States)] (1995) 160 Drug Retention Times Center for Human Reliability

  17. January 2013 Most Viewed Documents for Biology And Medicine | OSTI, US Dept

    Office of Scientific and Technical Information (OSTI)

    of Energy Office of Scientific and Technical Information January 2013 Most Viewed Documents for Biology And Medicine Nevada Test Site Radiological Control Manual Radiological Control Managers' Council Nevada Test Site Effects of ionizing radiation on the boreal forest: Canada's FIG experiment, with implications for radionuclides Amiro, B.D.; Sheppard, S.C Assessment of atmospheric metallic pollution in the metropolitan region of Sao Paulo, Brazil, employing Tillandsia usneoides L. as

  18. July 2013 Most Viewed Documents for Biology And Medicine | OSTI, US Dept of

    Office of Scientific and Technical Information (OSTI)

    Energy Office of Scientific and Technical Information July 2013 Most Viewed Documents for Biology And Medicine Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) 51 SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE GENERATOR SETS. KRISHNA,C.R. (1999) 46 Human radiation studies: Remembering the early years. Oral history of Donner Lab Administrator Baird G. Whaley, August 15, 1994 NONE (1995) 40 Human radiation studies:

  19. June 2014 Most Viewed Documents for Biology And Medicine | OSTI, US Dept of

    Office of Scientific and Technical Information (OSTI)

    Energy Office of Scientific and Technical Information June 2014 Most Viewed Documents for Biology And Medicine Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files Randolph Schwarz; Leland L. Carter; Alysia Schwarz (2005) 37 Geothermal demonstration: Zunil food dehydration facility Maldonado, O. (Consultecnia, Guatemala City (Guatemala)); Altseimer, J.; Thayer, G.R. (Los Alamos National Lab., NM (United States)); Cooper, L.

  20. June 2015 Most Viewed Documents for Biology And Medicine | OSTI, US Dept of

    Office of Scientific and Technical Information (OSTI)

    Energy Office of Scientific and Technical Information June 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. [Brookhaven National Lab., Upton, NY (United States)]|[State Univ. of New York at Stony Brook, Stony Brook, NY (United States). Dept. of Psychiatry]; Fowler, J.S.; Logan, J.; Wang, G.J. [Brookhaven National Lab., Upton, NY (United States)] (1995) 115 Dose and volume specification for reporting interstitial therapy

  1. March 2014 Most Viewed Documents for Biology And Medicine | OSTI, US Dept

    Office of Scientific and Technical Information (OSTI)

    of Energy Office of Scientific and Technical Information March 2014 Most Viewed Documents for Biology And Medicine Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) 30 Dose and volume specification for reporting interstitial therapy NONE (1997) 29 Geothermal demonstration: Zunil food dehydration facility Maldonado, O. (Consultecnia, Guatemala City (Guatemala)); Altseimer, J.; Thayer, G.R. (Los Alamos National Lab., NM

  2. Most Viewed Documents for Biology and Medicine: December 2014 | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy Office of Scientific and Technical Information Most Viewed Documents for Biology and Medicine: December 2014 Dose and volume specification for reporting interstitial therapy NONE (1997) 38 Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files Randolph Schwarz; Leland L. Carter; Alysia Schwarz (2005) 38 Drug Retention Times Center for Human Reliability Studies (2007) 34 Degradation of high concentrations of

  3. Most Viewed Documents for Biology and Medicine: September 2014 | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy Office of Scientific and Technical Information for Biology and Medicine: September 2014 Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files Randolph Schwarz; Leland L. Carter; Alysia Schwarz (2005) 32 Dose and volume specification for reporting interstitial therapy NONE (1997) 28 Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) 27 Drug

  4. Caribbean Equal Access Program: HIV/AIDS Information Resources from the National Library of Medicine

    SciTech Connect (OSTI)

    Nancy Dancy, NLM, and Wilma Templin-Branner, ORISE

    2009-01-01

    As the treatment and management of HIV/AIDS continues to evolve with new scientific breakthroughs, treatment discoveries, and management challenges, it is difficult for people living with HIV/AIDS and those who care for them to keep up with the latest information on HIV/AIDS prevention, treatment, and research. The National Library of Medicine, of the National Institutes of Health, has a wealth of health information resources freely available on the Internet to address these needs.

  5. TECTONIC VERSUS VOLCANIC ORIGIN OF THE SUMMIT DEPRESSION AT MEDICINE LAKE VOLCANO, CALIFORNIA

    SciTech Connect (OSTI)

    Mark Leon Gwynn

    2010-05-01

    Medicine Lake Volcano is a Quaternary shield volcano located in a tectonically complex and active zone at the transition between the Basin and Range Province and the Cascade Range of the Pacific Province. The volcano is topped by a 7x12 km elliptical depression surrounded by a discontinuous constructional ring of basaltic to rhyolitic lava flows. This thesis explores the possibility that the depression may have formed due to regional extension (rift basin) or dextral shear (pull-apart basin) rather than through caldera collapse and examines the relationship between regional tectonics and localized volcanism. Existing data consisting of temperature and magnetotelluric surveys, alteration mineral studies, and core logging were compiled and supplemented with additional core logging, field observations, and fault striae studies in paleomagnetically oriented core samples. These results were then synthesized with regional fault data from existing maps and databases. Faulting patterns near the caldera, extension directions derived from fault striae P and T axes, and three-dimensional temperature and alteration mineral models are consistent with slip across arcuate ring faults related to magma chamber deflation during flank eruptions and/or a pyroclastic eruption at about 180 ka. These results are not consistent with a rift or pull-apart basin. Limited subsidence can be attributed to the relatively small volume of ash-flow tuff released by the only known major pyroclastic eruption and is inconsistent with the observed topographic relief. The additional relief can be explained by constructional volcanism. Striae from unoriented and oriented core, augmented by striae measurements in outcrop suggest that Walker Lane dextral shear, which can be reasonably projected from the southeast, has probably propagated into the Medicine Lake area. Most volcanic vents across Medicine Lake Volcano strike north-south, suggesting they are controlled by crustal weakness related to Basin and

  6. Tectonic versus volcanic origin of the summit depression at Medicine Lake Volcano, California

    SciTech Connect (OSTI)

    Mark Leon Gwynn

    2010-05-01

    Medicine Lake Volcano is a Quaternary shield volcano located in a tectonically complex and active zone at the transition between the Basin and Range Province and the Cascade Range of the Pacific Province. The volcano is topped by a 7x12 km elliptical depression surrounded by a discontinuous constructional ring of basaltic to rhyolitic lava flows. This thesis explores the possibility that the depression may have formed due to regional extension (rift basin) or dextral shear (pull-apart basin) rather than through caldera collapse and examines the relationship between regional tectonics and localized volcanism. Existing data consisting of temperature and magnetotelluric surveys, alteration mineral studies, and core logging were compiled and supplemented with additional core logging, field observations, and fault striae studies in paleomagnetically oriented core samples. These results were then synthesized with regional fault data from existing maps and databases. Faulting patterns near the caldera, extension directions derived from fault striae P and T axes, and three-dimensional temperature and alteration mineral models are consistent with slip across arcuate ring faults related to magma chamber deflation during flank eruptions and/or a pyroclastic eruption at about 180 ka. These results are not consistent with a rift or pull-apart basin. Limited subsidence can be attributed to the relatively small volume of ash-flow tuff released by the only known major pyroclastic eruption and is inconsistent with the observed topographic relief. The additional relief can be explained by constructional volcanism. Striae from unoriented and oriented core, augmented by striae measurements in outcrop suggest that Walker Lane dextral shear, which can be reasonably projected from the southeast, has probably propagated into the Medicine Lake area. Most volcanic vents across Medicine Lake Volcano strike north-south, suggesting they are controlled by crustal weakness related to Basin and

  7. A New Route to Nano Self-Assembly

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    potential for breakthroughs that reverberate through nearly every sector of the economy (medicine, computing, energy, homeland security) is so great that it has already...

  8. Science and Technology Review March 2012 (Technical Report) ...

    Office of Scientific and Technical Information (OSTI)

    and (6) Chemical Sensor Is All Wires, No Batteries - Livermore's 'batteryless' nanowire sensor could benefit applications in diverse fields such as homeland security and medicine. ...

  9. GUIDELINES FOR BREASTFEEDING MOTHERS IN NUCLEAR MEDICINE LATEST REVISION DATE: 9/3/96

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GUIDELINES FOR BREASTFEEDING MOTHERS IN NUCLEAR MEDICINE LATEST REVISION DATE: 9/3/96 The material in this document has been developed as part of a NUREG document (1492). The data in this document may also be quoted as a personal communication from the Radiation Internal Dose Information Center. Please contact the center with any questions or comments about the data. Richard E. Toohey, 423-576-3448 phone, 423-576-8673 fax, tooheyr@orau.gov e-mail Audrey T. Stelson, 423-576-3450 phone,

  10. March 2015 Most Viewed Documents for Biology And Medicine | OSTI, US Dept

    Office of Scientific and Technical Information (OSTI)

    of Energy Office of Scientific and Technical Information 5 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. [Brookhaven National Lab., Upton, NY (United States)]|[State Univ. of New York at Stony Brook, Stony Brook, NY (United States). Dept. of Psychiatry]; Fowler, J.S.; Logan, J.; Wang, G.J. [Brookhaven National Lab., Upton, NY (United States)] (1995) 134 Drug Retention Times Center for Human Reliability Studies (2007) 114