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Sample records for hep medicine homeland

  1. Benefits of HEP | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Benefits of HEP High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Medicine Homeland Security Industry Computing Sciences Workforce Development A Growing List Accelerators for Americas Future External link Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us

  2. Medicine | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Medicine High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Medicine Homeland Security Industry Computing Sciences Workforce Development A Growing List Accelerators for Americas Future External link Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More

  3. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Presentations HEP Exascale Review Presentations Sort by: Default | Name | Date (low-high) | Date (high-low) | Source | Category HEP Requirements Review June 10, 2015 | Author(s): Barbara Helland, DOE ASCR | Download File: RequirementsreviewsHellandV3150610.pdf | pdf | 2.1 MB Opening Remarks June 10, 2015 | Author(s): Rob Roser, Salman Habib, Richard Gerber | Download File: HEP-ASCR-Exascale-opening-remarkssh.pdf | pdf | 187 KB P5 Science Drivers: Accelerator Experiments June 10, 2015 |

  4. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | 2.1 MB Opening Remarks June 10, 2015 | Author(s): Rob Roser, Salman Habib, Richard Gerber | Download File: HEP-ASCR-Exascale-opening-remarkssh.pdf | pdf | 187 KB Traditional...

  5. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | 2.1 MB Opening Remarks June 10, 2015 | Author(s): Rob Roser, Salman Habib, Richard Gerber | Download File: HEP-ASCR-Exascale-opening-remarkssh.pdf | pdf | 187 KB P5 Science...

  6. Homeland Security and Defense Applications

    ScienceCinema (OSTI)

    None

    2015-01-09

    Homeland Security and Defense Applications personnel are the best in the world at detecting and locating dirty bombs, loose nukes, and other radiological sources. The site trains the Nation's emergency responders, who would be among the first to confront a radiological or nuclear emergency. Homeland Security and Defense Applications highly training personnel, characterize the threat environment, produce specialized radiological nuclear detection equipment, train personnel on the equipment and its uses, test and evaluate the equipment, and develop different kinds of high-tech equipment to defeat terrorists. In New York City for example, NNSS scientists assisted in characterizing the radiological nuclear environment after 9/11, and produced specialized radiological nuclear equipment to assist local officials in their Homeland Security efforts.

  7. Homeland Renewable Energy LLC | Open Energy Information

    Open Energy Info (EERE)

    Homeland Renewable Energy LLC Jump to: navigation, search Name: Homeland Renewable Energy LLC Place: Langhorne, Pennsylvania Zip: 19047 Product: Holding company for Fibrowatt LLC...

  8. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Requirements Review June 10, 2015 | Author(s): Barbara Helland, DOE ASCR | Download File: RequirementsreviewsHellandV3150610.pdf | pdf | 2.1 MB Opening Remarks June 10, 2015 | Author(s): Rob Roser, Salman Habib, Richard Gerber | Download File: HEP-ASCR-Exascale-opening-remarkssh.pdf | pdf | 187 KB Traditional HPC needs: particle accelerators June 10, 2015 | Author(s): Jean-Luc Vay | Download File: DOEExascaleReviewVay.pdf | pdf | 19 MB P5 Science Drivers: Theory June 10, 2015 | Author(s):

  9. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALCF Future Systems June 10, 2015 | Author(s): Tim Williams | Download File: ExascaleReqsHEPALCF3systems.pdf | pdf | 3.1 MB ASCR Facility Plans June 10, 2015 | Author(s): Sudip Dosanjh | Download File: ASCR-Facilities-IntroHEP.pdf | pdf | 12 MB Computational Cosmology June 10, 2015 | Author(s): Katrin Heitmann | Download File: cosmohepascrheitmann.pdf | pdf | 6.5 MB Data Movement in HEP June 10, 2015 | Author(s): Brian Bockelman | Download File: Exascale-Data-Movement.pdf | pdf | 311 KB ESnet

  10. HEP-NERSCWorkshop.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP/NERSC Requirements Gathering Workshop Yukiko Sekine Program Manager, Facilities Division Advanced Scientific Computing Research Office of Science, DOE November 12 & 13, 2009 Advanced Scientific Computing Research Topics for Discussion * Current approaches to NERSC requirements gathering * Benefits of SC/HQ-centric requirements gathering for NERSC resources in the context of Programmatic mission needs * 2009 NERSC requirements gathering workshop schedule * An example outcome from

  11. HEP-Tsung.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    F. S. Tsung, HEP Workshop Project Summary -- Simulations of Plasma Based Accelerator Experiments Around the World. UCLA/IST is making a strong effort to quickly deploy simulation modeling to experimental teams - Laboratory frame simulations of LWFA's in OSIRIS - Boosted frame simulations of LWFA's in OSIRIS - Laboratory frame simulations of LWFA/PWFA's in QuickPIC Plasma based accelerators can achieve accelerating gradients 1,000 x that of those created by conventional accelerators. Recently, 2

  12. Amber_HEP-NERSC.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    DOE HEP Program Perspective HEP/NERSC Workshop November 12, 2009 2 What is High Energy Physics? The High Energy Physics (HEP) program mission is to understand how the universe works at its most fundamental level. We do this by:  Discovering the most elementary constituents of matter and energy,  Probing the interactions between them,  And exploring the basic nature of space and time. 3 The Three Frontiers of HEP  At the Energy Frontier, powerful accelerators are used to create new

  13. Department of Homeland Security's Science & Technology Directorate...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Homeland Security's Science & Technology Directorate Announces New Cybersecurity Risk ... Five of those technologies - Quantum Secured Communication, Hyperion, NeMS, PathScan and ...

  14. Reimbursable Work for Department of Homeland Security

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-02-28

    To authorize a modified process for the acceptance, performance, and administration of work from the Department of Homeland Security (DHS) by Department of Energy (DOE) contractor and federally operated laboratories, sites, and other facilities.

  15. NREL: Technology Deployment - Strengthening Homeland Security through

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sustainable Energy Strengthening Homeland Security through Sustainable Energy News Executive Order 13693 "Planning for Federal Sustainability in the Next Decade" Sponsors U.S. Department of Energy Key Partners U.S. Department of Homeland Security Related Stories U.S. Navy National Park Service U.S. Marine Corps Contact Rachel Romero, 303.275.3908 U.S. Customs and Border Protection Black Hawk helicopter flying above University of Phoenix Stadium, site of Super Bowl XLIX. Energy

  16. U.S. Homeland Security R&D Budgets

    SciTech Connect (OSTI)

    Halvorson, C S

    2009-03-30

    The FY09 budgets for homeland security research and development programs in the U.S. are summarized. Homeland security policy developments that can influence future efforts are discussed. Initial indications of the new administration direction on homeland security R&D are summarized. An overview of the Optics and Photonics in Global Homeland Security V conference is presented.

  17. HEP-Req_SLAC.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    For Accelerator Modeling Finite Element Approach Lie-Quan Lee SLAC National Accelerator Laboratory Large Scale Computing and Storage Requirements for High Energy Physics NERSC/ASCR/HEP Workshop, Washington D.C., November 12-13, 2009 NERSC Project * Project name: Advanced Modeling for Particle Accelerators * Principle Investigator: Kwok Ko * Participating institutions: - SLAC, BNL, FNAL, ORNL, TJNAF - CW09 Users * ANL * CERN * Cornell University * Los Alamos Lab * Michigan State University * Paul

  18. HEP/NP Requirements Review 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP/NP Requirements Review 2013 Science Engagement Move your data Programs & Workshops Science Requirements Reviews Network Requirements Reviews Documents and Background Materials FAQ for Case Study Authors BER Requirements Review 2015 ASCR Requirements Review 2015 Previous Reviews HEP/NP Requirements Review 2013 HEP Attendees 2013 FES Requirements Review 2014 BES Requirements Review 2014 Requirements Review Reports Case Studies Contact Us Technical Assistance: 1 800-33-ESnet (Inside US) 1

  19. NERSC/DOE HEP Requirements Workshop Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | DOE HEP Overview November 12, 2009 | Author(s): Amber Boehnlein | Workshop Logistics November 12, 2009 | Author(s): Harvey Wasserman | NERSC Role in High Energy Physics...

  20. Before the Senate Homeland Security and Governmental Affairs Subcommittee

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    on Contracting Oversight | Department of Energy Homeland Security and Governmental Affairs Subcommittee on Contracting Oversight Before the Senate Homeland Security and Governmental Affairs Subcommittee on Contracting Oversight Before the Senate Homeland Security and Governmental Affairs Subcommittee on Contracting Oversight By: Ingrid Kolb, Director Office of Management Subject: Improving Federal Contract Auditing PDF icon 02-01-2011 Final MA Testimony More Documents & Publications

  1. Department of Homeland Security's Science & Technology Directorate

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Announces New Cybersecurity Risk Analysis Tool on the Commercial Market | Department of Energy Homeland Security's Science & Technology Directorate Announces New Cybersecurity Risk Analysis Tool on the Commercial Market Department of Homeland Security's Science & Technology Directorate Announces New Cybersecurity Risk Analysis Tool on the Commercial Market April 14, 2016 - 10:19am Addthis News release from Pacific Northwest National Laboratory and the U.S. Department of Homeland

  2. Preliminary Benchmarking and MCNP Simulation Results for Homeland...

    Office of Scientific and Technical Information (OSTI)

    Preliminary Benchmarking and MCNP Simulation Results for Homeland Security Citation ... Visit OSTI to utilize additional information resources in energy science and technology. A ...

  3. Preliminary Benchmarking and MCNP Simulation Results for Homeland...

    Office of Scientific and Technical Information (OSTI)

    Preliminary Benchmarking and MCNP Simulation Results for Homeland Security Citation Details In-Document Search Title: Preliminary Benchmarking and MCNP Simulation Results for ...

  4. ORISE: California Homeland Security Exercise and Evaluation Program...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    California Homeland Security Exercise and Evaluation Program (HSEEP) Training The Oak Ridge Institute for Science and Education (ORISE) and the California Governor's Office of ...

  5. Before Senate Committee on Homeland Security and Governmental...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    on Homeland Security and Governmental Affairs, United States Senate By: Michael C. Kane, Chief Human Capital Officer, U.S. Department of Energy Subject: Inspiring Students to...

  6. Before the Senate Homeland Security and Governmental Affairs...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Before the Senate Homeland Security and Governmental Affairs Subcommittee on Contracting Oversight By: Ingrid Kolb, Director Office of Management Subject: Improving Federal ...

  7. Reimbursable Work for the Department of Homeland Security

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-08-17

    The Order establishes DOE policies and procedures for the acceptance, performance, and administration of reimbursable work directly funded by the Department of Homeland Security.

  8. HEP Budget | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Budget High Energy Physics (HEP) HEP Home About Organization Chart .pdf file (141KB) Staff HEP Budget HEP Committees of Visitors Directions Jobs University Research & National Labs Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More

  9. Science and Technology Challenges for Homeland Security

    SciTech Connect (OSTI)

    Murray, C A

    2006-03-24

    Preventing and protecting against catastrophic terrorism is a complex and dynamic challenge. Small groups or individuals can use advanced technology to cause massive destruction, and the rapid pace of technology and ease of information dissemination continually gives terrorists new tools. A 100% defense is not possible. It's a numbers problem--there are simply too many possible targets to protect and too many potential attack scenarios and adversaries to defend against. However, science and technology (S&T) is a powerful force multiplier for defense. We must use S&T to get ahead of the game by making terrorist attacks more difficult to execute, more likely to be interdicted, and less devastating in terms of casualties, economic damage, or lasting disruption. Several S&T areas have potential to significantly enhance homeland security efforts with regard to detecting radiation, pathogens, explosives, and chemical signatures of weapons activities. All of these areas require interdisciplinary research and development (R&D), and many critically depend on advances in materials science. For example, the science of nuclear signatures lies at the core of efforts to develop enhanced radiation detection and nuclear attribution capabilities. Current radiation detectors require cryogenic cooling and are too bulky and expensive. Novel signatures of nuclear decay, new detector materials that provide high resolution at ambient temperatures, and new imaging detectors are needed. Such technologies will improve our ability to detect and locate small, distant, or moving sources and to discriminate threat materials from legitimate sources. A more complete understanding of isotopic ratios via secondary ion mass spectrometry (SIMS), NanoSIMS, or yet-to-be-developed technologies is required to elucidate critical characteristics of nuclear materials (e.g., isotopics, age, reprocessing) in order to identify their source and route history. S&T challenges abound in the biodefense arena as well. Improved biodetectors are needed--autonomous instruments that continuously monitor the environment for threat pathogens, promptly alert authorities in the event of a positive detection, and have an extremely low false alarm rate. Because many threat pathogens are endemic to various regions of the world, the natural microbial environment must be characterized so that background detections can be distinguished from a deliberate release. In addition, most current detection approaches require an a priori knowledge of the pathogens of concern and thus won't work in the face of a new, naturally occurring disease, such as a mutated avian influenza that effects humans, or a deliberately manipulated organism. Thus, we must move from species-specific detection to function-based detection based on a fundamental understanding of the mechanisms and genetic markers of infectivity, pathogenicity, antibiotic resistance, and other traits that distinguish a harmful organism from an innocuous one. Last but not least, new vaccines and treatments are needed, which in turn require in-depth understanding of cellular surfaces, protein folding, and myriad nano-bio aspects of host-pathogen interactions. Much attention is being devoted to countering weapons-of-mass-destruction terrorism, since Al-Qaeda and other terrorist groups have repeatedly stated their intention to acquire and use nuclear, chemical, or biological weapons. However, terrorists in Iraq and elsewhere continue to wreak havoc using improvised explosive devices. Thus, there is a pressing security need for better methods for detecting explosive materials and devices. Transformational S&T such as pulsed fast-neutron analysis or terahertz spectroscopy for material- and element-specific imaging offer the promise of greatly improved explosive detection. For bioscience-based approaches, the development of highly multiplexed transducer arrays and molecular recognition methods that mimic biological systems would similarly provide the foundation for vastly improved capabilities. Likewise, new materials an

  10. Medicine Lodge Intermediate Facility

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Medicine Lodge

  11. High Energy Physics (HEP) Homepage | U.S. DOE Office of Science...

    Office of Science (SC) Website

    Programs HEP Home High Energy Physics (HEP) HEP Home About Research Facilities Science ... Resources Contact Information High Energy Physics U.S. Department of Energy SC-25...

  12. Using HEP Technology to Fight Cancer

    SciTech Connect (OSTI)

    Le Du, Patrick

    2004-06-30

    Many engineering and physics HEP groups are now collaborating with medical doctors and biomedical scientists to develop new modern and 'state of the art' radiation instruments for cancer diagnostics and treatment. This presentation will review some of these studies, oriented towards the imaging fields for diagnostic (Positron Emission Tomography and Computed Tomography) and particle therapy for tumor treatment (from proton to light ions). I will try, using appropriate examples, to show what are the challenges and where the development of HEP concepts, tools and techniques can be used.

  13. HEP-v2-for-dist

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Case S tudy: C on.nuing S tudies o f P lasma B ased Accelerators ( mp113) * PI: W. B. Mori (UCLA) * Presenter: F. S. Tsung (UCLA) Users: W. An, A. Davidson, V. K. Decyk, (UCLA), J. Vieira, L. Silva (IST), W. Lu (UCLA/ Tsinghua) F. S. Tsung, HEP Workshop HEP R equirements: Con.nuing S tudies o f P lasma B ased A ccelerators ( mp113) (PI: W . B . M ori, P resenter: F . S . T sung) An alternate scheme to accelerate particles using plasmas is the Plasma WakeField Accelerator (PWFA) concept where a

  14. HEP Science Network Requirements--Final Report

    SciTech Connect (OSTI)

    Bakken, Jon; Barczyk, Artur; Blatecky, Alan; Boehnlein, Amber; Carlson, Rich; Chekanov, Sergei; Cotter, Steve; Cottrell, Les; Crawford, Glen; Crawford, Matt; Dart, Eli; Dattoria, Vince; Ernst, Michael; Fisk, Ian; Gardner, Rob; Johnston, Bill; Kent, Steve; Lammel, Stephan; Loken, Stewart; Metzger, Joe; Mount, Richard; Ndousse-Fetter, Thomas; Newman, Harvey; Schopf, Jennifer; Sekine, Yukiko; Stone, Alan; Tierney, Brian; Tull, Craig; Zurawski, Jason

    2010-04-27

    The Energy Sciences Network (ESnet) is the primary provider of network connectivity for the US Department of Energy Office of Science, the single largest supporter of basic research in the physical sciences in the United States. In support of the Office of Science programs, ESnet regularly updates and refreshes its understanding of the networking requirements of the instruments, facilities, scientists, and science programs that it serves. This focus has helped ESnet to be a highly successful enabler of scientific discovery for over 20 years. In August 2009 ESnet and the Office of High Energy Physics (HEP), of the DOE Office of Science, organized a workshop to characterize the networking requirements of the programs funded by HEP. The International HEP community has been a leader in data intensive science from the beginning. HEP data sets have historically been the largest of all scientific data sets, and the communty of interest the most distributed. The HEP community was also the first to embrace Grid technologies. The requirements identified at the workshop are summarized below, and described in more detail in the case studies and the Findings section: (1) There will be more LHC Tier-3 sites than orginally thought, and likely more Tier-2 to Tier-2 traffic than was envisioned. It it not yet known what the impact of this will be on ESnet, but we will need to keep an eye on this traffic. (2) The LHC Tier-1 sites (BNL and FNAL) predict the need for 40-50 Gbps of data movement capacity in 2-5 years, and 100-200 Gbps in 5-10 years for HEP program related traffic. Other key HEP sites include LHC Tier-2 and Tier-3 sites, many of which are located at universities. To support the LHC, ESnet must continue its collaborations with university and international networks. (3) While in all cases the deployed 'raw' network bandwidth must exceed the user requirements in order to meet the data transfer and reliability requirements, network engineering for trans-Atlantic connectivity is more complex than network engineering for intra-US connectivity. This is because transoceanic circuits have lower reliability and longer repair times when compared with land-based circuits. Therefore, trans-Atlantic connectivity requires greater deployed bandwidth and diversity to ensure reliability and service continuity of the user-level required data transfer rates. (4) Trans-Atlantic traffic load and patterns must be monitored, and projections adjusted if necessary. There is currently a shutdown planned for the LHC in 2012 that may affect projections of trans-Atlantic bandwidth requirements. (5) There is a significant need for network tuning and troubleshooting during the establishment of new LHC Tier-2 and Tier-3 facilities. ESnet will work with the HEP community to help new sites effectively use the network. (6) SLAC is building the CCD camera for the LSST. This project will require significant bandwidth (up to 30Gbps) to NCSA over the next few years. (7) The accelerator modeling program at SLAC could require the movement of 1PB simulation data sets from the Leadership Computing Facilities at Argonne and Oak Ridge to SLAC. The data sets would need to be moved overnight, and moving 1PB in eight hours requires more than 300Gbps of throughput. This requirement is dependent on the deployment of analysis capabilities at SLAC, and is about five years away. (8) It is difficult to achieve high data transfer throughput to sites in China. Projects that need to transfer data in or out of China are encouraged to deploy test and measurement infrastructure (e.g. perfSONAR) and allow time for performance tuning.

  15. cet091110-hep_hpc.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Detector Simulation and Analysis Craig E. Tull, Ph.D. Staff Scientist/Group Leader Science Software Systems Group Computational Research Division Berkeley Lab Computing Sciences November 12, 2009 Rockville, MD HEP-HCG | Rockville | November 12, 2009 1. Detector Simulation and Analysis Overview Summarize the projects in your science area and their scientific objectives for the next 3-5 years * Current and past users of NERSC: - ATLAS - LHC accelerator at CERN, Geneva (PI: Ian Hinchliff) - Daya

  16. HEP-NUG-WS-forcray.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP/NERSC/ASCR Requirements Workshop Large Scale Computing and Storage Requirements for High Energy Physics NERSC Lawrence Berkeley National Laboratory Workshop Held Nov 12-13, 2009, Rockville, MD October 28, 2010, NERSC OSF, Oakland, CA! NERSC Requirements Workshops * Goal: Ensure that NERSC continues to provide the world-class facilities and services needed to support DOE Office of Science Research" * Method: Hold workshops to derive and document each DOE SC Office's HPC requirements for

  17. Department of Homeland Security | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Department of Homeland Security NNSA to Participate in Aerial Radiation Training Exercise in Philadelphia, Pennsylvania (WASHINGTON, D.C.) - On March 21 through March 24, the Department of Energy's National Nuclear Security Administration (NNSA) will participate in a federal and state/local training exercise in Philadelphia that will also include the Philadelphia Police Department and the Departments of Defense

  18. Reimbursable Work for the Department of Homeland Security

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-08-17

    The Order establishes DOE policies and procedures for the acceptance, performance, and administration of reimbursable work directly funded by the Department of Homeland Security. Cancels DOE N 481.1 and DOE N 251.62. Admin Chg 1, dated 3-14-11.

  19. Reimbursable Work for the Department of Homeland Security

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2006-08-17

    The Order establishes DOE policies and procedures for the acceptance, performance, and administration of reimbursable work directly funded by the Department of Homeland Security. Admin Chg 2, dated 6-30-14, supersedes DOE O 484.1 Admin Chg 1. Certified 1-15-15

  20. HEP Early Career Opportunities | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Early Career Opportunities High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Closed Funding Opportunity Announcements (FOAs) Closed Lab Announcements Award Search / Public Abstracts HEP Early Career Opportunities Review Policy / Proposal Guidelines / Reporting Requirements Additional Requirements and Guidance for Digital Data Management Acknowledgements of Federal Support Advisory Committees Community Resources Contact

  1. HEP Budget | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Budget Budget Budget Home About Budget by Program ASCR Budget BES Budget BER Budget FES Budget HEP Budget NP Budget WDTS Budget SLI Budget S&S Budget SCPD Budget GAO Audit Reports External Links Contact Information Budget U.S. Department of Energy SC-41/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3541 F: (301) 903-9524 More Information » Budget by Program HEP Budget Print Text Size: A A A FeedbackShare Page The following links contain HEP's budget

  2. Homeland Security | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Security Administration Homeland Security Presidential Directive (HSPD)-12 HSPD-12 mandates a common identification standard for all Federal employees and contractors who have a need to access government facilities and information systems. The NNSA goal is to develop a common solution for effective and secure logical and physical access for longer than six months. Individuals who have a valid need to access NNSA-owned security areas, facilities and information systems will be issued an

  3. Homeland Security Presidential Directive (HSPD)-12 | National Nuclear

    National Nuclear Security Administration (NNSA)

    Security Administration Homeland Security Presidential Directive (HSPD)-12 HSPD-12 mandates a common identification standard for all Federal employees and contractors who have a need to access government facilities and information systems. The NNSA goal is to develop a common solution for effective and secure logical and physical access for longer than six months. Individuals who have a valid need to access NNSA-owned security areas, facilities and information systems will be issued an

  4. Homeland Security and Emergency Management Coordination (HSEMC) Program |

    National Nuclear Security Administration (NNSA)

    National Nuclear Security Administration Homeland Security and Emergency Management Coordination (HSEMC) Program NNSA ensures that capabilities are in place to respond to any NNSA and Department of Energy facility emergency. It is also the nation's premier responder to any nuclear or radiological incident within the United States or abroad and provides operational planning and training to counter both domestic and international nuclear terrorism. NNSA ensures that capabilities are in place

  5. Unmanned and Unattended Response Capability for Homeland Defense

    SciTech Connect (OSTI)

    BENNETT, PHIL C.

    2002-11-01

    An analysis was conducted of the potential for unmanned and unattended robotic technologies for forward-based, immediate response capabilities that enables access and controlled task performance. The authors analyze high-impact response scenarios in conjunction with homeland security organizations, such as the NNSA Office of Emergency Response, the FBI, the National Guard, and the Army Technical Escort Unit, to cover a range of radiological, chemical and biological threats. They conducted an analysis of the potential of forward-based, unmanned and unattended robotic technologies to accelerate and enhance emergency and crisis response by Homeland Defense organizations. Response systems concepts were developed utilizing new technologies supported by existing emerging threats base technologies to meet the defined response scenarios. These systems will pre-position robotic and remote sensing capabilities stationed close to multiple sites for immediate action. Analysis of assembled systems included experimental activities to determine potential efficacy in the response scenarios, and iteration on systems concepts and remote sensing and robotic technologies, creating new immediate response capabilities for Homeland Defense.

  6. HEP Committees of Visitors | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEPAP Home » HEP Committees of Visitors High Energy Physics Advisory Panel (HEPAP) HEPAP Home Meetings 2016 HEPAP Membership Charges/Reports Charter .pdf file (44KB) HEP Committees of Visitors Federal Advisory Committees HEP Home HEP Committees of Visitors Print Text Size: A A A FeedbackShare Page High Energy Physics Advisory Panel (HEPAP) » The links below provide an archive of High Energy Physics (HEP) Committees of Visitors (COV) reports and responses. 2013 HEPAP COV Report on HEP Program

  7. HEP Supported Workshops & Conferences | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Sponsored Workshops and Conferences High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources News Archives Reports HEP Sponsored Workshops and Conferences Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » Community Resources HEP

  8. Active, Non-Intrusive Inspection Technologies for Homeland Defense

    SciTech Connect (OSTI)

    James L. Jones

    2003-06-01

    Active, non-intrusive inspection or interrogation technologies have been used for 100 years - with the primary focus being radiographic imaging. During the last 50 years, various active interrogation systems have been investigated and most have revealed many unique and interesting capabilities and advantages that have already benefited the general public. Unfortunately, except for medical and specific industrial applications, these unique capabilities have not been widely adopted, largely due to the complexity of the technology, the overconfident reliance on passive detection systems to handle most challenges, and the unrealistic public concerns regarding radiation safety issues for a given active inspection deployment. The unique homeland security challenges facing the United States today are inviting more "out-of-the-box" solutions and are demanding the effective technological solutions that only active interrogation systems can provide. While revolutionary new solutions are always desired, these technology advancements are rare, and when found, usually take a long time to fully understand and implement for a given application. What's becoming more evident is that focusing on under-developed, but well-understood, active inspection technologies can provide many of the needed "out-of-the-box" solutions. This paper presents a brief historical overview of active interrogation. It identifies some of the major homeland defense challenges being confronted and the commercial and research technologies presently available and being pursued. Finally, the paper addresses the role of the Idaho National Engineering and Environmental Laboratory and its partner, the Idaho Accelerator Center at Idaho State University, in promoting and developing active inspection technologies for homeland defense.

  9. Overview of accelerators with potential use in homeland security

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Garnett, Robert W.

    2015-01-01

    Quite a broad range of accelerators have been applied to solving many of the challenging problems related to homeland security and defense. These accelerator systems range from relatively small, simple, and compact, to large and complex, based on the specific application requirements. They have been used or proposed as sources of primary and secondary probe beams for applications such as radiography and to induce specific reactions that are key signatures for detecting conventional explosives or fissile material. A brief overview and description of these accelerator systems, their specifications, and application will be presented. Some recent technology trends will also bemore » discussed.« less

  10. Overview of accelerators with potential use in homeland security

    SciTech Connect (OSTI)

    Garnett, Robert W.

    2015-01-01

    Quite a broad range of accelerators have been applied to solving many of the challenging problems related to homeland security and defense. These accelerator systems range from relatively small, simple, and compact, to large and complex, based on the specific application requirements. They have been used or proposed as sources of primary and secondary probe beams for applications such as radiography and to induce specific reactions that are key signatures for detecting conventional explosives or fissile material. A brief overview and description of these accelerator systems, their specifications, and application will be presented. Some recent technology trends will also be discussed.

  11. HEP Collider HPC Use, Prospects and Wishes

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Collider HPC Use, Prospects and Wishes Tom L eCompte High E nergy P hysics D ivision Argonne N a4onal L aboratory 2 Outline § Overview o f t he S cience § Overview o f H PC u se T oday § Some E xtrapola?ons t o t he F uture I a m a n L HC e xperimenter. T his t alk i s a rranged a round t hat experience - a t t he p resent ? me, w e a re t he o nly m ajor experimental H EP g roup u sing H PCs a t t his s cale. 3 Collider Physics for Non-Physicists § We c ollide p ar?cles t

  12. A Geospatial Integrated Problem Solving Environment for Homeland Security Applications

    SciTech Connect (OSTI)

    Koch, Daniel B

    2010-01-01

    Effective planning, response, and recovery (PRR) involving terrorist attacks or natural disasters come with a vast array of information needs. Much of the required information originates from disparate sources in widely differing formats. However, one common attribute the information often possesses is physical location. The organization and visualization of this information can be critical to the success of the PRR mission. Organizing information geospatially is often the most intuitive for the user. In the course of developing a field tool for the U.S. Department of Homeland Security (DHS) Office for Bombing Prevention, a geospatial integrated problem solving environment software framework was developed by Oak Ridge National Laboratory. This framework has proven useful as well in a number of other DHS, Department of Defense, and Department of Energy projects. An overview of the software architecture along with application examples are presented.

  13. HEP Committees of Visitors | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Committees of Visitors High Energy Physics (HEP) HEP Home About Organization Chart .pdf file (141KB) Staff HEP Budget HEP Committees of Visitors Directions Jobs University Research & National Labs Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E:

  14. West Foster Creek Expansion Project 2007 HEP Report.

    SciTech Connect (OSTI)

    Ashley, Paul R.

    2008-02-01

    During April and May 2007, the Columbia Basin Fish and Wildlife Authority's (CBFWA) Regional HEP Team (RHT) conducted baseline Habitat Evaluation Procedures (HEP) (USFWS 1980, 1980a) analyses on five parcels collectively designated the West Foster Creek Expansion Project (3,756.48 acres). The purpose of the HEP analyses was to document extant habitat conditions and to determine how many baseline/protection habitat units (HUs) to credit Bonneville Power Administration (BPA) for funding maintenance and enhancement activities on project lands as partial mitigation for habitat losses associated with construction of Grand Coulee and Chief Joseph Dams. HEP evaluation models included mule deer (Odocoileus hemionus), western meadowlark (Sturnella neglecta), sharp-tailed grouse, (Tympanuchus phasianellus), Bobcat (Lynx rufus), mink (Neovison vison), mallard (Anas platyrhynchos), and black-capped chickadee (Parus atricapillus). Combined 2007 baseline HEP results show that 4,946.44 habitat units were generated on 3,756.48 acres (1.32 HUs per acre). HEP results/habitat conditions were generally similar for like cover types at all sites. Unlike crediting of habitat units (HUs) on other WDFW owned lands, Bonneville Power Administration received full credit for HUs generated on these sites.

  15. Shillapoo Wildlife Area 2007 Follow-up HEP Report.

    SciTech Connect (OSTI)

    Ashley, Paul R.

    2008-03-01

    In April and May 2007 the Regional HEP Team (RHT) conducted a follow-up HEP analysis on the Egger (612 acres) and Herzog (210 acres) parcels located at the north end of the Shillapoo Wildlife Area. The Egger and Herzog parcels have been managed with Bonneville Power Administration funds since acquired in 1998 and 2001 respectively. Slightly more than 936 habitat units (936.47) or 1.14 HUs per acre was generated as an outcome of the 2007 follow-up HEP surveys. Results included 1.65 black-capped chickadee HUs, 280.57 great blue heron HUs, 581.45 Canada goose HUs, 40 mallard HUs, and 32.80 mink HUs. Introduction A follow-up Habitat Evaluation Procedures (HEP) (USFWS 1980) analysis was conducted by the Columbia Basin Fish and Wildlife Authority's (CBFWA) Regional HEP Team (RHT) during April and May 2007 to document changes in habitat quality and to determine the number of habitat units (HUs) to credit Bonneville Power Administration (BPA) for providing operation and maintenance (O&M) funds since WDFW acquired the parcels. The 2007 follow-up HEP evaluation was limited to Shillapoo Wildlife Area (SWA) parcels purchased with Bonneville Power Administration funds. D. Budd (pers. comm.) reported WDFW purchased the 612 acre Egger Farms parcel on November 2, 1998 for $1,737,0001 and the 210 acre Herzog acquisition on June 21, 2001 for $500,000 with Memorandum of Agreement funds (BPA and WDFW 1996) as partial fulfillment of BPA's wildlife mitigation obligation for construction of Bonneville and John Day Dams (Rasmussen and Wright 1989). Anticipating the eventual acquisition of the Egger and Herzog properties, WDFW conducted HEP surveys on these lands in 1994 to determine the potential number of habitat units to be credited to BPA. As a result, HEP surveys and habitat unit calculations were completed as much as seven years prior to acquiring the sites. The term 'Shillapoo Wildlife Area' will be used to describe only the Herzog and Egger parcels in this document. Details and results of the HEP analysis are included in this report.

  16. DOE Order 484.1, Reimbursable Work for the Department of Homeland Security

    Office of Environmental Management (EM)

    Change | Department of Energy Order 484.1, Reimbursable Work for the Department of Homeland Security Change DOE Order 484.1, Reimbursable Work for the Department of Homeland Security Change The purpose of this Flash is to inform contracting personnel that the department issued an administrative change to DOE Order 484.1, Reimbursable Work for the Department of Homeland Security. The changes update organizational names and references. Attached is a summary of the change with the updated

  17. Before the House Subcommittee on Counterterrorism and Intelligence- Committee on Homeland Security

    Broader source: Energy.gov [DOE]

    Subject: Implications of Refinery Closures for U.S. Homeland Security and Critical Infrastructure Safety By: Howard Gruenspecht, Acting Administrator of the Energy Information Administration

  18. ORISE: U.S. Department of Homeland Security is seeking faculty...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    U.S. Department of Homeland Security is seeking faculty, graduate students and undergraduate students for summer 2016 research programs Deadlines to apply occur in December 2015...

  19. ORISE: U.S. Department of Homeland Security Summer Research Team Program

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    now accepting applications for 2015 now accepting applications for 2015 Summer Research Team Program with U.S. Department of Homeland Security Opportunities are open to research teams of faculty and students from Minority-Serving Institutions FOR IMMEDIATE RELEASE Nov. 25, 2014 FY15-03 OAK RIDGE, Tenn.-ORISE is currently accepting applications for the 2015 U.S. Department of Homeland Security Summer Research Team Program for Minority Serving Institutions (MSI). The program engages faculty

  20. ORISE: U.S. Department of Homeland Security is seeking faculty, graduate

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    students and undergraduate students for summer 2016 research programs U.S. Department of Homeland Security is seeking faculty, graduate students and undergraduate students for summer 2016 research programs Deadlines to apply occur in December 2015 FOR IMMEDIATE RELEASE Nov. 19, 2015 FY16-07 OAK RIDGE, Tenn.-The U.S. Department of Homeland Security (DHS) is seeking faculty, undergraduate and graduate students interested in participating in one of its 10-week programs in summer 2016, including

  1. Proposed New Accelerator Design for Homeland Security X-Ray Applications

    Office of Scientific and Technical Information (OSTI)

    (Conference) | SciTech Connect Proposed New Accelerator Design for Homeland Security X-Ray Applications Citation Details In-Document Search Title: Proposed New Accelerator Design for Homeland Security X-Ray Applications In the security and inspection market, there is a push towards highly mobile, reduced-dose active interrogation scanning and imaging systems to allow operation in urban environments. To achieve these goals, the accelerator system design needs to be smaller than existing

  2. White Paper on DOE-HEP Accelerator Modeling Science Activities

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    White Paper on DOE-HEP Accelerator Modeling Science Activities J.-L. Vay, C. G. R. Geddes, A. Koniges - Lawrence Berkeley National Laboratory A. Friedman, D. P. Grote - Lawrence Livermore National Laboratory D. L. Bruhwiler - RadiaSoft LLC J. P. Verboncoeur - Michigan State University Objective Toward the goal of maximizing the impact of computer modeling on the design of future particle accelerators and the development of new accelerator techniques & technologies, this white paper presents

  3. Katrin Heitmann DOE HEP/ASCR Exascale Requirements Review

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Katrin Heitmann DOE HEP/ASCR Exascale Requirements Review June 10, 2015 Computational Cosmology Katrin Heitmann, Los Alamos National Laboratory Benasque Cosmology Workshop, August 2010 Roles of Cosmological Simulations in DE Survey Science * First part of end-to-end simulation * Control of systematics (1) Cosmology simulations and the survey (2) Solving the Inverse Problem from the LSST Science Book Cosmology Mock catalogs Athmosphere Optics Detector Images * Exploring fundamental physics *

  4. HEP-FCE Working Group on Libraries and Tools

    SciTech Connect (OSTI)

    Borgland, Anders; Elmer, Peter; Kirby, Michael; Patton, Simon; Potekhin, Maxim; Viren, Brett; Yanny, Brian

    2014-12-19

    The High-Energy Physics Forum for Computational Excellence (HEP-FCE) was formed by the Department of Energy as a follow-up to a recent report from the Topical Panel on Computing[1] and the associated P5 recommendation[2]. It is a pilot project distributed across the DOE Labs. During this initial incubation period the Forum is to develop a plan for a robust, long-term organization structure and a functioning web presence for forum activities and outreach, and a study of hardware and software needs across the HEP program. In the following sections we give this working group’s “vision” for aspects and qualities we wish to see in a future HEP-FCE. We then give a prioritized list of technical activities with suggested scoping and deliverables that can be expected to provide cross-experiment benefits. The remaining bulk of the report gives a technical survey of some specific “areas of opportunity” for cross-experiment benefit in the realm of software libs/tools. This survey serves as support for the vision and prioritized list. For each area we describe the ways that cross-experiment benefit is achieved today, as well as describe known failings or pitfalls where such benefit has failed to be achieved and which should be avoided in the future. For both cases, we try to give concrete examples. Each area then ends with an examination of what opportunities exist for improvements in that particular area.

  5. Measurements of the {sup 6}He+p resonant scattering

    SciTech Connect (OSTI)

    Condori, R. Pampa; Lichtenthler, R.; Lpine-Szily, A.; Gasques, L. R.; Morais, M. C.; Scarduelli, V. B.; Leistenschneider, E.; Alcntara-Nez, J. A.; Faria, P. N. de; Mendes Jr, D. R.; Pires, K. C. C.; Shorto, J. M. B.

    2014-11-11

    Measurements of the p({sup 6}He,p) elastic scattering excitation function have been performed in the RIBRAS system using a {sup 6}He secondary beam and a CH{sub 2} polyethylene thick target. The motivation is to observe states of the compound nucleus {sup 7}Li in the excitation energy range of E{sub exc}{sup 7Li}?=?10.8-11.8MeV, where the isobaric analog state of {sup 7}He ground state lies. Excitation functions have been obtained at three laboratory angles ?{sub lab} = 0, 20, and 25 which correspond to ?{sub c.m} = 180, 140, and 130.

  6. Before the House Subcommittee on Emerging Threats, Cyber Security and Science and Technology Committee on Homeland Security

    Broader source: Energy.gov [DOE]

    Before the House Subcommittee on Emerging Threats, Cyber Security and Science and Technology Committee on Homeland SecurityBy: Patricia Hoffman, Acting Assistant Secretary for Electricity Delivery...

  7. NREL Earns Award For Efforts in Homeland Security - News Releases | NREL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Earns Award For Efforts in Homeland Security February 10, 2004 Golden, Colo. - The Federal Laboratory Consortium for Technology (FLC) has recognized the Department of Energy's National Renewable Energy Laboratory with an award for Outstanding Technology Development in recognition of the Lab's long-term efforts for "Using Renewables to Safeguard the Energy Infrastructure of the U.S." "This award recognizes the outstanding work of all our Laboratory staff," said Tom Williams,

  8. Homeland security: safeguarding America's future with energy efficiency and renewable energy technologies

    SciTech Connect (OSTI)

    None, None

    2002-08-01

    The State Energy Advisory Board (STEAB) presents this 10th annual report following the one-year anniversary of the September 11, 2001 terrorist attacks on the World Trade Center and the Pentagon. This event has had profound impacts on all segments of American society, not the least of which is this countrys energy sector. Long before September 11, a number of energy issues grabbed the nations attention, including opening the Arctic National Wildlife Refuge to oil and natural gas exploration, the power crisis in California, nationwide natural gas and gasoline price increases, and the administrations May 2001 National Energy Policy. However, the events of September 11 refocused attention on the prominent role energy plays in the countrys homeland security. For the most part, the energy aspects of homeland security have focused on the physical security of critical energy emergency planning and energy infrastructure, such as power plants, refineries, and power and fuel transmission systems. While STEAB recognizes the importance of protecting our existing energy infrastructure, this should not be the sole focus of homeland security as it relates to energy.

  9. Habitat Evaluation Procedures (HEP) Report : Grand Coulee Dam Mitigation, 1996-1999 Technical Report.

    SciTech Connect (OSTI)

    Kieffer, B.; Singer, Kelly; Abrahamson, Twa-le

    1999-07-01

    The purpose of this Habitat Evaluation Procedures (HEP) study was to determine baseline habitat units and to estimate future habitat units for Bonneville Power Administration (BPA) mitigation projects on the Spokane Indian Reservation. The mitigation between BPA and the Spokane Tribe of Indians (STOI) is for wildlife habitat losses on account of the construction of Grand Coulee Dam. Analysis of the HEP survey data will assist in mitigation crediting and appropriate management of the mitigation lands.

  10. Detector systems for future HEP experiments (Journal Article) | SciTech

    Office of Scientific and Technical Information (OSTI)

    Connect SciTech Connect Search Results Journal Article: Detector systems for future HEP experiments Citation Details In-Document Search Title: Detector systems for future HEP experiments Some thoughts are presented on the development of detector systems for future high energy physics experiments. These systems must be able to achieve simultaneous, reliable, high-efficiency identification and measurement of all objects that make up an 'event'. This will require a world-wide collaborative

  11. HEP Committees of Visitors | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    HEP Committees of Visitors Deputy Director for Science Programs Deputy Director Home Mission & Functions Deputy Director Biography Organization Staff Presentations & Testimony Federal Advisory Committees Committees of Visitors ASCR Committees of Visitors BES Committees of Visitors BER Committees of Visitors FES Committees of Visitors HEP Committees of Visitors NP Committees of Visitors WDTS Committees of Visitors Contact Information Deputy Director for Science Programs U.S. Department of

  12. Risk Assessment Using The Homeland-Defense Operational Planning System (HOPS)

    SciTech Connect (OSTI)

    Price, D E; Durling, R L

    2005-10-10

    The Homeland-Defense Operational Planning System (HOPS), is a new operational planning tool leveraging Lawrence Livermore National Laboratory's expertise in weapons systems and in sparse information analysis to support the defense of the U.S. homeland. HOPS provides planners with a basis to make decisions to protect against acts of terrorism, focusing on the defense of facilities critical to U.S. infrastructure. Criticality of facilities, structures, and systems is evaluated on a composite matrix of specific projected casualty, economic, and sociopolitical impact bins. Based on these criteria, significant unidentified vulnerabilities are identified and secured. To provide insight into potential successes by malevolent actors, HOPS analysts strive to base their efforts mainly on unclassified open-source data. However, more cooperation is needed between HOPS analysts and facility representatives to provide an advantage to those whose task is to defend these facilities. Evaluated facilities include: refineries, major ports, nuclear power plants and other nuclear licensees, dams, government installations, convention centers, sports stadiums, tourist venues, and public and freight transportation systems. A generalized summary of analyses of U.S. infrastructure facilities will be presented.

  13. High-Resolution Laser-Induced Breakdown Spectroscopy used in Homeland Security and Forensic Applications

    SciTech Connect (OSTI)

    Martin, Madhavi Z; Wullschleger, Stan D; Vass, Arpad Alexander; Martin, Rodger Carl; Grissino-Mayer, Henri

    2006-01-01

    The technique of laser-induced breakdown spectroscopy (LIBS) to detect elements for a variety of homeland security applications such as nuclear materials identification and inventory,and forensic applications has been demonstrated. For nuclear materials applications, we detected and profiled metals in coatings that were used to encapsulate nuclear fuel. Multivariate analysis has been successfully employed in the quantification of elements present in treated wood and engineered wood composites. These examples demonstrate that LIBS-based techniques are inherently well suited for diverse environmental applications related to homeland security. Three key advantages are evident: (1) small samples (mg) are sufficient; (2) samples can be analyzed by LIBS very rapidly, and (3) biological materials such as human and animal bones and wood can be analyzed with minimal sample preparation. For forensic applications they have used LIBS to determine differences in animal and human bones. They have also applied this technique in the determination of counterfeit and non-counterfeit currency. They recently applied LIBS in helping to solve a murder case.

  14. Oxidative stress induced lipid accumulation via SREBP1c activation in HepG2 cells

    SciTech Connect (OSTI)

    Sekiya, Mika; Hiraishi, Ako; Touyama, Maiko [Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8572 (Japan); Sakamoto, Kazuichi [Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8572 (Japan)], E-mail: sakamoto@biol.tsukuba.ac.jp

    2008-10-31

    SREBP1c (sterol regulatory element-binding protein 1c) is a metabolic-syndrome-associated transcription factor that controls fatty acid biosynthesis under glucose/insulin stimulation. Oxidative stress increases lipid accumulation, which promotes the generation of reactive oxygen species (ROS). However, we know little about the role of oxidative stress in fatty acid biosynthesis. To clarify the action of oxidative stress in lipid accumulation via SREBP1c, we examined SREBP1c activity in H{sub 2}O{sub 2}-treated mammalian cells. We introduced a luciferase reporter plasmid carrying the SREBP1c-binding site into HepG2 or COS-7 cells. With increasing H{sub 2}O{sub 2} dose, SREBP1c transcriptional activity increased in HepG2 cells but declined in COS-7 cells. RT-PCR analysis revealed that mRNA expression of SREBP1c gene or of SREBP1c-regulated genes rose H{sub 2}O{sub 2} dose-dependently in HepG2 cells but dropped in COS-7 cells. Lipid accumulation and levels of the nuclear form of SREBP1c increased in H{sub 2}O{sub 2}-stimulated HepG2 cells. ROS may stimulate lipid accumulation in HepG2 cells via SREBP1c activation.

  15. A Growing List | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Growing List High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Medicine Homeland Security Industry Computing Sciences Workforce Development A Growing List Accelerators for Americas Future External link Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us

  16. Gold-Stud Bump Bonding for HEP Applications (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Conference: Gold-Stud Bump Bonding for HEP Applications Citation Details In-Document Search Title: Gold-Stud Bump Bonding for HEP Applications Authors: Tripathi, S.M. ; /UC, Davis ; Holbrook, B. ; /UC, Davis ; Irving, M. ; /UC, Davis ; Lander, R.L. ; /UC, Davis ; Woods, M. ; /UC, Davis ; Brau, J.E. ; /Oregon U. ; Frey, R.E. ; /Oregon U. ; Strom, D. ; /Oregon U. ; Breidenbach, M. ; /SLAC ; Freytag, D. ; /SLAC more »; Haller, G. ; /SLAC ; Herbst, R. ; /SLAC ; Jaros, J. ; /SLAC ; Nelson, T. ;

  17. HepSim: A Repository with Predictions for High-Energy Physics Experiments

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Chekanov, S. V.

    2015-01-01

    A file repository for calculations of cross sections and kinematic distributions using Monte Carlo generators for high-energy collisions is discussed. The repository is used to facilitate effective preservation and archiving of data from theoretical calculations and for comparisons with experimental data. The HepSim data library is publicly accessible and includes a number of Monte Carlo event samples with Standard Model predictions for current and future experiments. The HepSim project includes a software package to automate the process of downloading and viewing online Monte Carlo event samples. Data streaming over a network for end-user analysis is discussed.

  18. West Foster Creek 2007 Follow-up Habitat Evaluation Procedures (HEP) Report.

    SciTech Connect (OSTI)

    Ashley, Paul R.

    2008-02-01

    A follow-up habitat evaluation procedures (HEP) analysis was conducted on the West Foster Creek (Smith acquisition) wildlife mitigation site in May 2007 to determine the number of additional habitat units to credit Bonneville Power Administration (BPA) for providing funds to enhance and maintain the project site as partial mitigation for habitat losses associated with construction of Grand Coulee Dam. The West Foster Creek 2007 follow-up HEP survey generated 2,981.96 habitat units (HU) or 1.51 HUs per acre for a 34% increase (+751.34 HUs) above baseline HU credit (the 1999 baseline HEP survey generated 2,230.62 habitat units or 1.13 HUs per acre). The 2007 follow-up HEP analysis yielded 1,380.26 sharp-tailed grouse (Tympanuchus phasianellus) habitat units, 879.40 mule deer (Odocoileus hemionus) HUs, and 722.29 western meadowlark (Sturnella neglecta) habitat units. Mule deer and sharp-tailed grouse habitat units increased by 346.42 HUs and 470.62 HUs respectively over baseline (1999) survey results due largely to cessation of livestock grazing and subsequent passive restoration. In contrast, the western meadowlark generated slightly fewer habitat units in 2007 (-67.31) than in 1999, because of increased shrub cover, which lowers habitat suitability for that species.

  19. Deputy Assistant Secretary Matt Moury's Written Testimony Before the Subcommittee on Financial and Contracting Oversight Committee on Homeland Security and Government Affairs (March 11, 2014)

    Broader source: Energy.gov [DOE]

    Written statement of Deputy Assistant Secretary Matt Moury's Written Testimony Before the Subcommittee on Financial and Contracting Oversight Committee on Homeland Security and Government Affairs...

  20. Occupational Medicine - Assistant PIA, Idaho National Laboratory...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Medicine - Assistant PIA, Idaho National Laboratory Occupational Medicine - Assistant PIA, Idaho National Laboratory Occupational Medicine - Assistant PIA, Idaho National ...

  1. Occupational Medicine - Assistant PIA, Idaho National Laboratory...

    Energy Savers [EERE]

    Occupational Medicine - Assistant PIA, Idaho National Laboratory Occupational Medicine - Assistant PIA, Idaho National Laboratory Occupational Medicine - Assistant PIA, Idaho...

  2. PIA - Richland Occupational Medicine Contract | Department of...

    Energy Savers [EERE]

    PIA - Richland Occupational Medicine Contract PIA - Richland Occupational Medicine Contract PIA - Richland Occupational Medicine Contract PDF icon PIA - Richland Occupational...

  3. Barbara Helland Advanced Scientific Computing Research NERSC-HEP Requirements Review

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    7-28, 2012 Barbara Helland Advanced Scientific Computing Research NERSC-HEP Requirements Review 1 Science C ase S tudies d rive d iscussions Program R equirements R eviews  Program offices evaluated every two-three years  Participants include program managers, PI/ Scientists, ESnet/NERSC staff and management  User-driven discussion of science opportunities and needs  What: Instruments and facilities, data scale, computational requirements  How: science process, data analysis,

  4. PIA - Richland Occupational Medicine Contract | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Medicine Contract PIA - Richland Occupational Medicine Contract PIA - Richland Occupational Medicine Contract PDF icon PIA - Richland Occupational Medicine Contract More Documents ...

  5. U. S. Government purposes. ANL-HEP-CP-88-42

    Office of Scientific and Technical Information (OSTI)

    authored bv a comracior>oi the U. S. Government under contract No. W-31-109-ENG-38, Accordingly, the U. S. Government retains a nonexclusive, royalty-tree license to publish or reproduce the published form of this contribution, or allow others to do so, for U. S. Government purposes. ANL-HEP-CP-88-42 DE89 003647 NUCLEAR DEPENDENCE OF STRUCTURE FUNCTIONS IN THE SHADOWING REGION OF DEEP INELASTIC SCATTERING* EDMOND L. BERGER and JIANWEI QIU High Energy Physics Division, Argonne Natiorjd

  6. Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2

    Office of Scientific and Technical Information (OSTI)

    hepatoma cell line (Journal Article) | SciTech Connect SciTech Connect Search Results Journal Article: Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line Citation Details In-Document Search Title: Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line Diterpenoid tanshinones including tanshinone IIA (TIIA), cryptotanshinone (CTS), tanshinone I (TI) and dihydrotanshinone I (DHTI) are the major bioactive components

  7. Occupational Medicine Variance Request

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Laboratory | Department of Energy Medical Surveillance System (OMSS) PIA, Idaho National Laboratory Occupational Medical Surveillance System (OMSS) PIA, Idaho National Laboratory Occupational Medical Surveillance System (OMSS) PIA, Idaho National Laboratory PDF icon Occupational Medical Surveillance System (OMSS) PIA, Idaho National Laboratory More Documents & Publications Occupational Medicine - Assistant PIA, Idaho National Laboratory Occupational Injury & Illness System

  8. Habitat Evaluation Procedures (HEP) Report : Hellsgate Project, 1999-2000 Technical Report.

    SciTech Connect (OSTI)

    Berger, Matthew

    2000-05-01

    A Habitat Evaluation Procedure (HEP) study was conducted on lands acquired and/or managed (4,568 acres total) by the Hellsgate Big Game Winter Range Wildlife Mitigation Project (Hellsgate project) to mitigate some of the losses associated with the original construction and operation of Grand Coulee Dam and inundation of habitats behind the dams. Three separate properties, totaling 2,224 acres were purchased in 1998. One property composed of two separate parcels, mostly grassland lies southeast of the town of Nespelem in Okanogan County (770 acres) and was formerly called the Hinman property. The former Hinman property lies within an area the Tribes have set aside for the protection and preservation of the sharp-tailed grouse (Agency Butte unit). This special management area minus the Hinman acquisition contains 2,388 acres in a long-term lease with the Tribes. The second property lies just south of the Silver Creek turnoff (Ferry County) and is bisected by the Hellsgate Road (part of the Friedlander unit). This parcel contains 60 acres of riparian and conifer forest cover. The third property (now named the Sand Hills unit) acquired for mitigation (1,394 acres) lies within the Hellsgate Reserve in Ferry County. This new acquisition links two existing mitigation parcels (the old Sand Hills parcels and the Lundstrum Flat parcel, all former Kuehne purchases) together forming one large unit. HEP team members included individuals from the Colville Confederated Tribes Fish and Wildlife Department (CTCR), Washington Department of Fish and Wildlife (WDFW), and Bureau of Land Management (BLM). The HEP team conducted a baseline habitat survey using the following HEP species models: mule deer (Odocoileus hemionus), mink (Mustela vison), downy woodpecker (Picoides pubescens), bobcat (Lynx rufus), yellow warbler (Dendroica petechia), and sharp-tailed grouse (Tympanuchus phasianellus columbianus). HEP analysis and results are discussed within the body of the text. The cover types evaluated for this study were grasslands, shrub-steppe, rock, conifer forest and woodland, and riparian. These same cover types were evaluated for other Hellsgate Project acquisitions within the same geographic area. Mule deer habitat on the Sand Hills unit rated good overall for winter food and cover in the shrub-steppe and conifer woodland cover types. Sharp-tailed grouse habitat on the former Hinman property and special management area rated good for nesting and brood rearing in the grassland cover type. Mink habitat on the Friedlander parcel rated poor due to lack of food and cover in and along the riparian cover type. The Downy woodpecker rated poor for food and cover on the Friedlander parcel in the conifer forest cover type. This species also rated poor on the conifer woodland habitat on the Hinman parcel. Yellow warbler habitat on the Agency Butte Special Management area rated very poor due to lack of shrubs for cover and reproduction around the scattered semi/permanent ponds that occur on the area. Bobcat habitat on this same area rated poor due to lack of cover and food. Fragmentation of existing quality habitat is also a problem for both these species. This report is an analysis of baseline habitat conditions on mitigation and managed lands, and provides estimated habitat units for mitigation crediting purposes. In addition, this information will be used to manage these lands for the benefit of wildlife.

  9. Habitat Evaluation Procedures (HEP) Report; Precious Lands Wildlife Management Area, Technical Report 2000-2003.

    SciTech Connect (OSTI)

    Kozusko, Shana

    2003-12-01

    The Nez Perce Tribe (NPT) currently manages a 15,325 acre parcel of land known as the Precious Lands Wildlife Management Area that was purchased as mitigation for losses incurred by construction of the four lower Snake River dams. The Management Area is located in northern Wallowa County, Oregon and southern Asotin County, Washington (Figure 1). It is divided into three management parcels--the Buford parcel is located on Buford Creek and straddles the WA-OR state line, and the Tamarack and Basin parcels are contiguous to each other and located between the Joseph Creek and Cottonwood Creek drainages in Wallowa County, OR. The project was developed under the Pacific Northwest Electric Power Planning and Conservation Act of 1980 (P.L. 96-501), with funding from the Bonneville Power Administration (BPA). The acreage protected under this contract will be credited to BPA as habitat permanently dedicated to wildlife and wildlife mitigation. A modeling strategy known as Habitat Evaluation Procedure (HEP) was developed by the U.S. Fish and Wildlife Service and adopted by BPA as a habitat equivalency accounting system. Nine wildlife species models were used to evaluate distinct cover type features and provide a measure of habitat quality. Models measure a wide range of life requisite variables for each species and monitor overall trends in vegetation community health and diversity. One product of HEP is an evaluation of habitat quality expressed in Habitat Units (HUs). This HU accounting system is used to determine the amount of credit BPA receives for mitigation lands. After construction of the four lower Snake River dams, a HEP loss assessment was conducted to determine how many Habitat Units were inundated behind the dams. Twelve target species were used in that evaluation: Canada goose, mallard, river otter, downy woodpecker, song sparrow, yellow warbler, marsh wren, western meadowlark, chukar, ring-necked pheasant, California quail, and mule deer. The U.S. Army Corp of Engineers and the Washington Department of fish and Wildlife subsequently purchased numerous properties to mitigate for the identified Snake River losses. These projects, however, were not sufficient to mitigate for all the HU's lost. The Northwest Power Planning Council amended the remaining 26,774 HU's into their 1994-1995 Fish and Wildlife Program as being unmitigated (NPPC 2000), which allowed the Nez Perce Tribe to contract with BPA to provide HU's through the Precious Lands Project. The Precious Lands project contains a different composition of cover types than those assessed during the lower Snake loss assessment. For example, no mallard or Canada goose habitat exists on Precious Lands but the area does contain conifer forest, which was not present on the area inundated by dam construction. These cover type differences have resulted in a slightly different suite of species for the current HEP assessment. Target species for Precious Lands are downy woodpecker, yellow warbler, song sparrow, California Quail, mule deer, sharp-tailed grouse (brood rearing), west em meadowlark, beaver, and black-capped chickadee. This list is a reflection of the available cover types and the management objectives of the Nez Perce Tribe. For example, chukar was not used in the present assessment because it is an introduced Eurasian game bird that does not provide an accurate representation of the ecological health of the native grasslands it was supposed to represent. Initial model runs using the chukar confirmed this suspicion so the brood-rearing section of the sharp-tailed grouse model was used instead. Additionally, the beaver model was used in place of the river otter model because the otter model used in the loss assessment was not a published model, was overly simplistic, and did not provide an accurate assessment of riparian condition. The beaver model, however, provides a detailed evaluation of overstory class structure that the NPT felt was a good compliment to the yellow warbler and song sparrow models that evaluated understory shrub layers. Overall, such substitutions should result in a more accurate evaluation of the ecological conditions on Precious Lands, and provide better information for decision making. A baseline HEP analysis was initiated on the Precious Lands in 2000, and data collection continued throughout the 2001 and 2002 field seasons. In the future, HEP analysis will be used to evaluate habitat changes resulting from management activities. Repeat surveys will be useful in assessing long-term trends in plant community health, weed encroachment, wildlife limiting factors, habitat degradation, and establishing desired future condition guidelines for the management program.

  10. Occupational Medicine | The Ames Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    state regulations. The Occupational Medicine office enhances the efficiency of existing safety and health programs and assists in the reduction of workplace injuries and illnesses....

  11. Habitat Evaluation Procedures (HEP) Report : Rainwater Wildlife Area, 1998-2001 Technical Report.

    SciTech Connect (OSTI)

    Childs, Allen

    2004-01-01

    The 8,768 acre Rainwater Wildlife Area was acquired in September 1998 by the Confederated Tribes of the Umatilla Indian Reservation (CTUIR) through an agreement with Bonneville Power Administration (BPA) to partially offset habitat losses associated with construction of the John Day and McNary hydroelectric facilities on the mainstem Columbia River. U.S. Fish and Wildlife Service (USFWS) Habitat Evaluation Procedures (HEP) were used to determine the number of habitat units credited to BPA for acquired lands. Upland and riparian forest, upland and riparian shrub, and grassland rover types are evaluated in this study. Targeted wildlife species include downy woodpecker (Picoides pubescens), black-capped chickadee (Parus atricopillus), blue grouse (Dendragapus obscurus), great blue heron (Ardea herodias), yellow warbler (Dendroica petechia), mink (Mustela vison), and Western meadowlark (Sturnella neglects). Habitat surveys were conducted in 1998 and 1999 in accordance with published HEP protocols and included 65,300, 594m{sup 2} plots, and 112 one-tenth-acre plots. Between 153.3 and 7,187.46 acres were evaluated for each target wildlife mitigation species. Derived habitat suitability indices were multiplied by corresponding cover-type acreages to determine the number of habitat units for each species. The total baseline habitat units credited to BPA for the Rainwater Wildlife Area and its seven target species is 5,185.3 habitat units. Factors limiting habitat suitability are related to the direct, indirect, and cumulative effects of past livestock grazing, road construction, and timber harvest which have simplified the structure, composition, and diversity of native plant communities. Alternatives for protecting and improving habitat suitability include exclusion of livestock grazing, road de-commissioning/obliteration, reforestation and thinning, control of competing and unwanted vegetation (including noxious weeds), reestablishing displaced or reduced native vegetation species, allowance of normative processes such as fire occurrence, and facilitating development of natural stable stream channels and associated floodplains. Implementation of habitat enhancement and restoration activities could generate an additional 1,850 habitat units in 10 years. Baseline and estimated future habitat units total 7,035.3 for the Rainwater Wildlife Area. Habitat protection, enhancement and restoration will require long-term commitments from managers to increase probabilities of success and meet the goals and objectives of the Northwest Power Planning Council's Fish and Wildlife Mitigation Program. Longer-term benefits of protection and enhancement activities include increases in native species diversity and plant community resiliency in all cover types. Watershed conditions, including floodplain/riparian, and instream habitat quality should improve as well providing multiple benefits for terrestrial and aquatic resources. While such benefits are not necessarily recognized by HEP models and reflected in the number of habitat units generated, they are consistent with the NPPC Fish and Wildlife Program.

  12. SAMPLING AND MASS SPECTROMETRY APPROACHES FOR THE DETECTION OF DRUGS AND FOREIGN CONTAMINANTS IN BREATH FOR HOMELAND SECURITY APPLICATIONS

    SciTech Connect (OSTI)

    Martin, A N

    2009-01-27

    Homeland security relies heavily on analytical chemistry to identify suspicious materials and persons. Traditionally this role has focused on attribution, determining the type and origin of an explosive, for example. But as technology advances, analytical chemistry can and will play an important role in the prevention and preemption of terrorist attacks. More sensitive and selective detection techniques can allow suspicious materials and persons to be identified even before a final destructive product is made. The work presented herein focuses on the use of commercial and novel detection techniques for application to the prevention of terrorist activities. Although drugs are not commonly thought of when discussing terrorism, narcoterrorism has become a significant threat in the 21st century. The role of the drug trade in the funding of terrorist groups is prevalent; thus, reducing the trafficking of illegal drugs can play a role in the prevention of terrorism by cutting off much needed funding. To do so, sensitive, specific, and robust analytical equipment is needed to quickly identify a suspected drug sample no matter what matrix it is in. Single Particle Aerosol Mass Spectrometry (SPAMS) is a novel technique that has previously been applied to biological and chemical detection. The current work applies SPAMS to drug analysis, identifying the active ingredients in single component, multi-component, and multi-tablet drug samples in a relatively non-destructive manner. In order to do so, a sampling apparatus was created to allow particle generation from drug tablets with on-line introduction to the SPAMS instrument. Rules trees were developed to automate the identification of drug samples on a single particle basis. A novel analytical scheme was also developed to identify suspect individuals based on chemical signatures in human breath. Human breath was sampled using an RTube{trademark} and the trace volatile organic compounds (VOCs) were preconcentrated using solid phase microextraction (SPME) and identified using gas chromatography - mass spectrometry (GC-MS). Modifications to the sampling apparatus allowed for increased VOC collection efficiency, and reduced the time of sampling and analysis by over 25%. The VOCs are present in breath due to either endogenous production, or exposure to an external source through absorption, inhalation, or ingestion. Detection of these exogenous chemicals can provide information on the prior location and activities of the subject. Breath samples collected before and after exposure in a hardware store and nail salon were analyzed to investigate the prior location of a subject; breath samples collected before and after oral exposure to terpenes and terpenoid compounds, pseudoephedrine, and inhalation exposure to hexamine and other explosive related compounds were analyzed to investigate the prior activity of a subject. The elimination of such compounds from the body was also monitored. In application, this technique may provide an early warning system to identify persons of interest in the prevention and preemption stages of homeland security.

  13. Cyclosporine A and palmitic acid treatment synergistically induce cytotoxicity in HepG2 cells

    SciTech Connect (OSTI)

    Luo, Yi Rana, Payal; Will, Yvonne

    2012-06-01

    Immunosuppressant cyclosporine A (CsA) treatment can cause severe side effects. Patients taking immunosuppressant after organ transplantation often display hyperlipidemia and obesity. Elevated levels of free fatty acids have been linked to the etiology of metabolic syndromes, nonalcoholic fatty liver and steatohepatitis. The contribution of free fatty acids to CsA-induced toxicity is not known. In this study we explored the effect of palmitic acid on CsA-induced toxicity in HepG2 cells. CsA by itself at therapeutic exposure levels did not induce detectible cytotoxicity in HepG2 cells. Co-treatment of palmitic acid and CsA resulted in a dose dependent increase in cytotoxicity, suggesting that fatty acid could sensitize cells to CsA-induced cytotoxicity at the therapeutic doses of CsA. A synergized induction of caspase-3/7 activity was also observed, indicating that apoptosis may contribute to the cytotoxicity. We demonstrated that CsA reduced cellular oxygen consumption which was further exacerbated by palmitic acid, implicating that impaired mitochondrial respiration might be an underlying mechanism for the enhanced toxicity. Inhibition of c-Jun N-terminal kinase (JNK) attenuated palmitic acid and CsA induced toxicity, suggesting that JNK activation plays an important role in mediating the enhanced palmitic acid/CsA-induced toxicity. Our data suggest that elevated FFA levels, especially saturated FFA such as palmitic acid, may be predisposing factors for CsA toxicity, and patients with underlying diseases that would elevate free fatty acids may be susceptible to CsA-induced toxicity. Furthermore, hyperlipidemia/obesity resulting from immunosuppressive therapy may aggravate CsA-induced toxicity and worsen the outcome in transplant patients. -- Highlights: ? Palmitic acid and cyclosporine (CsA) synergistically increased cytotoxicity. ? The impairment of mitochondrial functions may contribute to the enhanced toxicity. ? Inhibition of JNK activity attenuated palmitate/ CsA induced toxicity. ? Palmitate sensitizes cells to the toxicity induced by CsA at therapeutic exposure. ? Elevated free fatty acids may predispose the patients to CsA-induced toxicity.

  14. Nuclear medicine imaging system

    DOE Patents [OSTI]

    Bennett, Gerald W.; Brill, A. Bertrand; Bizais, Yves J. C.; Rowe, R. Wanda; Zubal, I. George

    1986-01-01

    A nuclear medicine imaging system having two large field of view scintillation cameras mounted on a rotatable gantry and being movable diametrically toward or away from each other is disclosed. In addition, each camera may be rotated about an axis perpendicular to the diameter of the gantry. The movement of the cameras allows the system to be used for a variety of studies, including positron annihilation, and conventional single photon emission, as well as static orthogonal dual multi-pinhole tomography. In orthogonal dual multi-pinhole tomography, each camera is fitted with a seven pinhole collimator to provide seven views from slightly different perspectives. By using two cameras at an angle to each other, improved sensitivity and depth resolution is achieved. The computer system and interface acquires and stores a broad range of information in list mode, including patient physiological data, energy data over the full range detected by the cameras, and the camera position. The list mode acquisition permits the study of attenuation as a result of Compton scatter, as well as studies involving the isolation and correlation of energy with a range of physiological conditions.

  15. Occupational Medicine Workshops and Webinars

    Broader source: Energy.gov [DOE]

    The DOE Annual Occupational Medicine Workshop & Webinar (OMWW) is a valuable training opportunity established by the Office of Health, Safety, and Security in support of hundreds of medical and allied health professionals located at over four dozen locations across the Department. Their vital work in the field of Occupational Medicine encompasses medical qualification examinations, injury and illness management, disability management, workers’ compensation, and much more.

  16. Eicosapentaenoic acid (EPA) induced apoptosis in HepG2 cells through ROSCa{sup 2+}JNK mitochondrial pathways

    SciTech Connect (OSTI)

    Zhang, Yuanyuan; Han, Lirong; Qi, Wentao; Cheng, Dai; Ma, Xiaolei; Hou, Lihua; Cao, Xiaohong; Wang, Chunling

    2015-01-24

    Highlights: EPA evoked ROS formation, [Ca{sup 2+}]{sub c} accumulation, the opening of MPTP and the phosphorylation of JNK. EPA-induced [Ca{sup 2+}]{sub c} elevation was depended on production of ROS. EPA-induced ROS generation, [Ca{sup 2+}]{sub c} increase, and JNK activated caused MPTP opening. The apoptosis induced by EPA was related to release of cytochrome C through the MPTP. EPA induced HepG2 cells apoptosis through ROSCa{sup 2+}JNK mitochondrial pathways. - Abstract: Eicosapentaenoic acid (EPA), a well-known dietary n?3 PUFAS, has been considered to inhibit proliferation of tumor cells. However, the molecular mechanism related to EPA-induced liver cancer cells apoptosis has not been reported. In this study, we investigated the effect of EPA on HepG2 cells proliferation and apoptosis mechanism through mitochondrial pathways. EPA inhibited proliferation of HepG2 cells in a dose-dependent manner and had no significant effect on the cell viability of humor normal liver L-02 cells. It was found that EPA initially evoked ROS formation, leading to [Ca{sup 2+}]{sub c} accumulation and the mitochondrial permeability transition pore (MPTP) opening; EPA-induced HepG2 cells apoptosis was inhibited by N-acetylcysteine (NAC, an inhibitor of ROS), 1,2-bis (2-aminophenoxy) ethane-N,N,N?,N?-tetraacetic acid (BAPTA-AM, a chelator of calcium) and CsA (inhibitor of MPTP). The relationship between ROS production, the increase of cytoplasmic Ca and MPTP opening was detected. It seems that ROS may act as an upstream regulator of EPA-induced [Ca{sup 2+}]{sub c} generation, moreover, generation of ROS, overload of mitochondrial [Ca{sup 2+}]{sub c}, and JNK activated cause the opening of MPTP. Western blotting results showed that EPA elevated the phosphorylation status of JNK, processes associated with the ROS generation. Simultaneously, the apoptosis induced by EPA was related to release of cytochrome C from mitochondria to cytoplasm through the MPTP and activation of caspase-9 and caspase-3. These results suggest that EPA induces apoptosis through ROSCa{sup 2+}JNK mitochondrial pathways.

  17. OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle

    SciTech Connect (OSTI)

    Zhong, Wenbin; Zhou, You; Li, Jiwei; Mysore, Raghavendra; Luo, Wei; Li, Shiqian; Chang, Mau-Sun; Olkkonen, Vesa M.; Yan, Daoguang

    2014-04-01

    We earlier identified OSBP-related protein 8 (ORP8) as an endoplasmic reticulum/nuclear envelope oxysterol-binding protein implicated in cellular lipid homeostasis, migration, and organization of the microtubule cytoskeleton. Here, a yeast two-hybrid screen identified Homo sapiens sperm associated antigen 5 (SPAG5)/Astrin as interaction partner of ORP8. The putative interaction was further confirmed by pull-down and co-immunoprecipitation assays. ORP8 did not colocalize with kinetochore-associated SPAG5 in mitotic HepG2 or HuH7 cells, but overexpressed ORP8 was capable of recruiting SPAG5 onto endoplasmic reticulum membranes in interphase cells. In our experiments, 25-hydroxycholesterol (25OHC) retarded the HepG2 cell cycle, causing accumulation in G2/M phase; ORP8 overexpression resulted in the same phenotype. Importantly, ORP8 knock-down dramatically inhibited the oxysterol effect on HepG2 cell cycle, suggesting a mediating role of ORP8. Furthermore, knock-down of SPAG5 significantly reduced the effects of both ORP8 overexpression and 25OHC on the cell cycle, placing SPAG5 downstream of the two cell-cycle interfering factors. Taken together, the present results suggest that ORP8 may via SPAG5 mediate oxysterol interference of the HepG2 cell cycle. - Highlights: The oxysterol-binding protein ORP8 was found to interact with the mitotic regulator SPAG5/Astrin. Treatment of HepG2 cells with 25-hydroxycholesterol caused cell cycle retardation in G2/M. ORP8 overexpression caused a similar G2/M accumulation, and ORP8 knock-down reversed the 25-hydroxycholesterol effect. Reduction of cellular of SPAG5/Astrin reversed the cell cycle effects of both 25-hydroxycholesterol and ORP8 overexpression. Our results suggest that ORP8 mediates via SPAG5/Astrin the oxysterol interference of HepG2 cell cycle.

  18. AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS...

    Office of Scientific and Technical Information (OSTI)

    Converting energy to medical progress nuclear medicine NONE 62 RADIOLOGY AND NUCLEAR MEDICINE; DIAGNOSIS; DISEASES; GAMMA CAMERAS; GENETICS; NUCLEAR MEDICINE; PATIENTS; RADIATION...

  19. RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; NUCLEAR MEDICINE; HISTORICAL

    Office of Scientific and Technical Information (OSTI)

    The early days Richards, P. 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; NUCLEAR MEDICINE; HISTORICAL ASPECTS; TECHNETIUM 99; COLLOIDS; MOLYBDENUM...

  20. LRD-22, a novel dual dithiocarbamatic acid ester, inhibits Aurora-A kinase and induces apoptosis and cell cycle arrest in HepG2 cells

    SciTech Connect (OSTI)

    Wang, Huiling; Li, Ridong; Li, Li; Ge, Zemei; Zhou, Rouli; Li, Runtao

    2015-02-27

    In this study we investigated the antitumor activity of the novel dual dithiocarbamatic acid ester LRD-22 in vitro and in vivo. Several cancer cell lines were employed to determine the effect of LRD-22 on cell growth, and the MTT assay showed there was a significant decrease in viable tumor cell numbers in the presence of LRD-22, especially in the HepG2 cell line. Colony formation assay also showed LRD-22 strongly inhibits HepG2 cell growth. Evaluation of the mechanism involved showed that inhibitory effects of LRD-22 on cell growth are due to induction of apoptosis and G2/M arrest. LRD-22 inhibited Aurora-A phosphorylation at Thr{sub 288} and subsequently impaired p53 phosphorylation at Ser{sub 315} which was associated with the proteasome degradation pathway. Tumor suppressor protein p53 is stabilized by this mechanism and accumulates through inhibition of Aurora-A kinase activity via treatment with LRD-22. In vivo study of HepG2 xenograft in nude mice also shows LRD-22 suppresses tumor growth at a concentration of 5 mg/kg without animals suffering loss of body weight. In conclusion, our results demonstrate LRD-22 acts as an Aurora-A kinase inhibitor to induce apoptosis and inhibit proliferation in HepG2 cells, and should be considered as a promising targeting agent for HCC therapy. - Highlights: • LRD-22 significantly inhibits cancer cell growth, especially in the HepG2 cell line. • The inhibitory effect of LRD-22 is due to induction of apoptosis and cell cycle arrest. • LRD-22 inhibits Aurora-A phosphorylation which results in subsequent impairment of the p53 pathway. • LRD-22 suppresses tumor growth in xenograft mice without body weight loss.

  1. Homeland Security Presidential Directive 7

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Sector-Specific Agencies, there are special functions of various Federal departments and agencies and components of the Executive Office of the President related to critical ...

  2. Department of Homeland Security | NISAC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Disclosure | Department of Energy Department of Energy-funded Bioenergy Research Centers File 500th Invention Disclosure Department of Energy-funded Bioenergy Research Centers File 500th Invention Disclosure March 7, 2016 - 2:47pm Addthis News release from Oak Ridge National Laboratory and the Great Lakes Bioenergy Research Center OAK RIDGE, Tenn., March 3, 2016-Three U.S. Department of Energy-funded research centers - the BioEnergy Science Center (Oak Ridge National Laboratory), the Great

  3. Impact of Nuclear Medicine on Emergency Response

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    February » Impact of Nuclear Medicine on Emergency Response Impact of Nuclear Medicine on Emergency Response WHEN: Feb 26, 2016 6:00 PM - 8:00 PM WHERE: Courtyard Marriott, Santa Fe CONTACT: Evelyn Mullen (505) 665-7576 CATEGORY: Community TYPE: Meeting INTERNAL: Calendar Login Event Description A number of novel isotopes and associated drug compounds are being developed, both in the US and elsewhere, for diagnosis and therapy in the field of nuclear medicine. The accelerator at Los Alamos is

  4. Medicine Lake Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Page Technique Activity Start Date Activity End Date Reference Material Geothermal Literature Review At Medicine Lake Geothermal Area (1984) Geothermal Literature Review 1984...

  5. Internalisation and multiple phosphorylation of γ-Conglutin, the lupin seed glycaemia-lowering protein, in HepG2 cells

    SciTech Connect (OSTI)

    Capraro, Jessica; Magni, Chiara; Faoro, Franco; Maffi, Dario; Scarafoni, Alessio; Tedeschi, Gabriella; Maffioli, Elisa; Parolari, Anna; Manzoni, Cristina; Lovati, Maria Rosa; Duranti, Marcello

    2013-08-09

    Highlights: •A glycaemia-reducing lupin seed protein is internalized by HepG2 cells. •The protein accumulates in the cytosol in an intact form. •The internalized protein is multiply phosphorylated. -- Abstract: Lupin seed γ-Conglutin is a protein capable of reducing glycaemia in mammalians and increasing glucose uptake by model cells. This work investigated whether γ-Conglutin is internalised into the target cells and undergoes any covalent change during the process, as a first step to understanding its mechanism of action. To this purpose, γ-Conglutin-treated and untreated HepG2 cells were submitted to confocal and transmission electron microscopy. Immune-revelation of γ-Conglutin at various intervals revealed its accumulation inside the cytosol. In parallel, 2D-electrophoresis of the cell lysates and antibody reaction of the blotted maps showed the presence of the protein intact subunits inside the treated cells, whilest no trace of the protein was found in the control cells. However, γ-Conglutin-related spots with an unexpectedly low pI were also observed in the maps. These spots were excised, trypsin-treated and submitted to MS/MS spectrometric analysis. The presence of phosphorylated amino acids was detected. These findings, by showing that γ-Conglutin is internalised by HepG2 cells in an intact form and is modified by multiple phosphorylation, open the way to the understanding of the lupin γ-Conglutin insulin-mimetic activity.

  6. Improved Meteorological Input for Atmospheric Release Decision support Systems and an Integrated LES Modeling System for Atmospheric Dispersion of Toxic Agents: Homeland Security Applications

    SciTech Connect (OSTI)

    Arnold, E; Simpson, M; Larsen, S; Gash, J; Aluzzi, F; Lundquist, J; Sugiyama, G

    2010-04-26

    When hazardous material is accidently or intentionally released into the atmosphere, emergency response organizations look to decision support systems (DSSs) to translate contaminant information provided by atmospheric models into effective decisions to protect the public and emergency responders and to mitigate subsequent consequences. The Department of Homeland Security (DHS)-led Interagency Modeling and Atmospheric Assessment Center (IMAAC) is one of the primary DSSs utilized by emergency management organizations. IMAAC is responsible for providing 'a single piont for the coordination and dissemination of Federal dispersion modeling and hazard prediction products that represent the Federal position' during actual or potential incidents under the National Response Plan. The Department of Energy's (DOE) National Atmospheric Release Advisory Center (NARAC), locatec at the Lawrence Livermore National Laboratory (LLNL), serves as the primary operations center of the IMAAC. A key component of atmospheric release decision support systems is meteorological information - models and data of winds, turbulence, and other atmospheric boundary-layer parameters. The accuracy of contaminant predictions is strongly dependent on the quality of this information. Therefore, the effectiveness of DSSs can be enhanced by improving the meteorological options available to drive atmospheric transport and fate models. The overall goal of this project was to develop and evaluate new meteorological modeling capabilities for DSSs based on the use of NASA Earth-science data sets in order to enhance the atmospheric-hazard information provided to emergency managers and responders. The final report describes the LLNL contributions to this multi-institutional effort. LLNL developed an approach to utilize NCAR meteorological predictions using NASA MODIS data for the New York City (NYC) region and demonstrated the potential impact of the use of different data sources and data parameterizations on IMAAC/NARAC fate and transport predictions. A case study involving coastal sea breeze circulation patterns in the NYC region was used to investigate the sensitivity of atmospheric dispersion results on the source of three-dimensional wind field data.

  7. Symes Hotel and Medicinal Springs Pool & Spa Low Temperature...

    Open Energy Info (EERE)

    Symes Hotel and Medicinal Springs Pool & Spa Low Temperature Geothermal Facility Jump to: navigation, search Name Symes Hotel and Medicinal Springs Pool & Spa Low Temperature...

  8. Medicine Bow Wind Farm II | Open Energy Information

    Open Energy Info (EERE)

    II Jump to: navigation, search Name Medicine Bow Wind Farm II Facility Medicine Bow Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Platte...

  9. Medicine Bow Wind Farm IV | Open Energy Information

    Open Energy Info (EERE)

    IV Jump to: navigation, search Name Medicine Bow Wind Farm IV Facility Medicine Bow Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Platte...

  10. Static Temperature Survey At Medicine Lake Area (Warpinski, Et...

    Open Energy Info (EERE)

    GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Static Temperature Survey At Medicine Lake Area (Warpinski, Et Al., 2002) Exploration Activity Details Location Medicine...

  11. Mercury Vapor At Medicine Lake Area (Kooten, 1987) | Open Energy...

    Open Energy Info (EERE)

    Medicine Lake Area (Kooten, 1987) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Mercury Vapor At Medicine Lake Area (Kooten, 1987) Exploration...

  12. Medicine Bow Wind Farm III | Open Energy Information

    Open Energy Info (EERE)

    III Jump to: navigation, search Name Medicine Bow Wind Farm III Facility Medicine Bow Sector Wind energy Facility Type Small Scale Wind Facility Status In Service Owner Platte...

  13. Medicine Hot Springs Pool & Spa Low Temperature Geothermal Facility...

    Open Energy Info (EERE)

    Pool & Spa Low Temperature Geothermal Facility Jump to: navigation, search Name Medicine Hot Springs Pool & Spa Low Temperature Geothermal Facility Facility Medicine Hot...

  14. Medicine Bow Wind Farm I | Open Energy Information

    Open Energy Info (EERE)

    I Jump to: navigation, search Name Medicine Bow Wind Farm I Facility Medicine Bow Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Platte...

  15. Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans

    SciTech Connect (OSTI)

    Atienzar, Franck A.; Novik, Eric I.; Gerets, Helga H.; Parekh, Amit; Delatour, Claude; Cardenas, Alvaro; MacDonald, James; Yarmush, Martin L.; Dhalluin, Stphane

    2014-02-15

    Drug Induced Liver Injury (DILI) is a major cause of attrition during early and late stage drug development. Consequently, there is a need to develop better in vitro primary hepatocyte models from different species for predicting hepatotoxicity in both animals and humans early in drug development. Dog is often chosen as the non-rodent species for toxicology studies. Unfortunately, dog in vitro models allowing long term cultures are not available. The objective of the present manuscript is to describe the development of a co-culture dog model for predicting hepatotoxic drugs in humans and to compare the predictivity of the canine model along with primary human hepatocytes and HepG2 cells. After rigorous optimization, the dog co-culture model displayed metabolic capacities that were maintained up to 2 weeks which indicates that such model could be also used for long term metabolism studies. Most of the human hepatotoxic drugs were detected with a sensitivity of approximately 80% (n = 40) for the three cellular models. Nevertheless, the specificity was low approximately 40% for the HepG2 cells and hepatocytes compared to 72.7% for the canine model (n = 11). Furthermore, the dog co-culture model showed a higher superiority for the classification of 5 pairs of close structural analogs with different DILI concerns in comparison to both human cellular models. Finally, the reproducibility of the canine system was also satisfactory with a coefficient of correlation of 75.2% (n = 14). Overall, the present manuscript indicates that the dog co-culture model may represent a relevant tool to perform chronic hepatotoxicity and metabolism studies. - Highlights: Importance of species differences in drug development. Relevance of dog co-culture model for metabolism and toxicology studies. Hepatotoxicity: higher predictivity of dog co-culture vs HepG2 and human hepatocytes.

  16. HEP Exascale Review Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALCF Future Systems June 10, 2015 | Author(s): Tim Williams | Download File: ExascaleReqsHEPALCF3systems.pdf | pdf | 3.1 MB ASCR Facility Plans June 10, 2015 | Author(s): Sudip...

  17. hep.ppt

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Overview * 3 NERSC repositories - mp107: O(10) NSFNASADOEinternational suborbital experiments - planck: current ESANASA satellite mission (with DOE IAA) - cmbpol: proposed ...

  18. HEP Final Project Report

    SciTech Connect (OSTI)

    Chen, Chunhui

    2013-05-21

    In this report, we summarize the research activity funded by the DOE award DE-FG02-12ER41827 (DE-SC0007892) during the funding period (May 1, 2012- March 31, 2013).

  19. HEP Open Funding Opportunities

    Office of Science (SC) Website

    - and is the principal federal funding agency of - the Nation's research programs in high-energy physics, nuclear physics, and fusion energy sciences. en 8BF3F791-EE84-4768-BCDF-E...

  20. HEP Science Highlights

    Office of Science (SC) Website

    neutrinos and antineutrinos are the same particle, and to see if neutrinos respect a natural symmetry, the reversal of time, need to be carried out. The discovery also...

  1. HEP_Exaflop_brower

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Requirements Reviews: High Energy Physics Rich Brower (SciDAC software co-director/CUDA fellow) June 10, 2015 Lattice Field Theory Strong Dynamics in Standard Model and Beyond * PRECISION P HYSICS * M ul/---scale A LGORITHMS * Parallel S OFTWARE/HARDWARE 3 P art U SQCD P rogram 2 Algorithm Application Architecture Hard to find Sweet Spot CM-2 100 Mflops (1989) BF/Q 1 Pflops (2012) Future GPU/PHI architectures will soon get us there! What about spectacular Algorithms/Software? 10 7 increase in 25

  2. Report on Department of Homeland Security Sponsored Research Project at Lawrence Livermore National Laboratory on Preparation for an Improvised Nuclear Device Event

    SciTech Connect (OSTI)

    A., B

    2008-07-31

    Following the events of September 11th, a litany of imaginable horribles was trotted out before an anxious and concerned public. To date, government agencies and academics are still grappling with how to best respond to such catastrophes, and as Senator Lieberman's quote says above, now is the time to plan and prepare for such events. One of the nation's worst fears is that terrorists might detonate an improvised nuclear device (IND) in an American city. With 9/11 serving as the catalyst, the government and many NGOs have invested money into research and development of response capabilities throughout the country. Yet, there is still much to learn about how to best respond to an IND event. My summer 2008 internship at Lawrence Livermore National Laboratory afforded me the opportunity to look in depth at the preparedness process and the research that has been conducted on this issue. While at the laboratory I was tasked to collect, combine, and process research on how cities and the federal government can best prepare for the horrific prospect of an IND event. Specific projects that I was involved with were meeting reports, research reviews, and a full project report. Working directly with Brooke Buddemeier and his support team at the National Atmospheric Release Advisory Center, I was able to witness first hand, preparation for meetings with response planners to inform them of the challenges that an IND event would pose to the affected communities. In addition, I supported the Homeland Security Institute team (HSI), which was looking at IND preparation and preparing a Congressional report. I participated in meetings at which local responders expressed their concerns and contributed valuable information to the response plan. I specialized in the psycho-social aspects of an IND event and served as a technical advisor to some of the research groups. Alongside attending and supporting these meetings, I worked on an independent research project which collected information from across disciplines to outline where the state of knowledge on IND response is. In addition, the report looked at meetings that were held over the summer in various cities. The meetings were attended by both federal responders and local responders. The meetings explored issues regarding IND preparation and how to mitigate the effects of an IND detonation. Looking at the research and current preparation activity the report found that the state of knowledge in responding and communicating is a mixed bag. Some aspects of an IND attack are well understood, some are not, but much is left to synthesize. The effects of an IND would be devastating, yet much can be done to mitigate those effects through education, preparation, and research. A major gap in current knowledge is how to effectively communicate with the public before an attack. Little research on the effectiveness of public education has been done, but it is likely that educating the public about the effects of an IND and how to best protect oneself could save many lives.

  3. LABORATORY OF NUCLEAR MEDICINE AND RADIATION BIOLOGY

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    MEDICINE AND RADIATION BIOLOGY 900 VETERAN AVENUE UNIVERSITY OF CALIFORNIA, LOS ANGELES, CALIFORNIA 90024 AND DEPARTMENT OF RADIOLOGICAL SCIENCES UCLA SCHOOL OF MEDICINE, LOS ANGELES, CALIFORNIA 90024 This manuscript is a contribution to the monograph edited by Daniel S. Berman and Dean Mason, entitled "Clinical Nuclear Cardiology". These studies were supported by Contract #DE-AM03-76-SF00012 between the U.S. Department of Energy and the University of California Prepared for the U.S.

  4. Biology and Medicine Division: Annual report 1986

    SciTech Connect (OSTI)

    Not Available

    1987-04-01

    The Biology and Medicine Division continues to make important contributions in scientific areas in which it has a long-established leadership role. For 50 years the Division has pioneered in the application of radioisotopes and charged particles to biology and medicine. There is a growing emphasis on cellular and molecular applications in the work of all the Division's research groups. The powerful tools of genetic engineering, the use of recombinant products, the analytical application of DNA probes, and the use of restriction fragment length polymorphic DNA are described and proposed for increasing use in the future.

  5. Fermilab | Science | Particle Physics | Benefits of Particle...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Homeland Security In this Section: thumb Medicine thumb Homeland Security thumb Industry thumb Computing thumb Sciences thumb Workforce Development thumb A Growing List Homeland...

  6. Adaptation of HepG2 cells to a steady-state reduction in the content of protein phosphatase 6 (PP6) catalytic subunit

    SciTech Connect (OSTI)

    Boylan, Joan M.; Salomon, Arthur R.; Tantravahi, Umadevi; Gruppuso, Philip A.

    2015-07-15

    Protein phosphatase 6 (PP6) is a ubiquitous Ser/Thr phosphatase involved in an array of cellular processes. To assess the potential of PP6 as a therapeutic target in liver disorders, we attenuated expression of the PP6 catalytic subunit in HepG2 cells using lentiviral-transduced shRNA. Two PP6 knock-down (PP6KD) cell lines (90% reduction of PP6-C protein content) were studied in depth. Both proliferated at a rate similar to control cells. However, flow cytometry indicated G2/M cell cycle arrest that was accounted for by a shift of the cells from a diploid to tetraploid state. PP6KD cells did not show an increase in apoptosis, nor did they exhibit reduced viability in the presence of bleomycin or taxol. Gene expression analysis by microarray showed attenuated anti-inflammatory signaling. Genes associated with DNA replication were downregulated. Mass spectrometry-based phosphoproteomic analysis yielded 80 phosphopeptides representing 56 proteins that were significantly affected by a stable reduction in PP6-C. Proteins involved in DNA replication, DNA damage repair and pre-mRNA splicing were overrepresented among these. PP6KD cells showed intact mTOR signaling. Our studies demonstrated involvement of PP6 in a diverse set of biological pathways and an adaptive response that may limit the effectiveness of targeting PP6 in liver disorders. - Highlights: • Lentiviral-transduced shRNA was used to generate a stable knockdown of PP6 in HepG2 cells. • Cells adapted to reduced PP6; cell proliferation was unaffected, and cell survival was normal. • However, PP6 knockdown was associated with a transition to a tetraploid state. • Genomic profiling showed downregulated anti-inflammatory signaling and DNA replication. • Phosphoproteomic profiling showed changes in proteins associated with DNA replication and repair.

  7. Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells

    SciTech Connect (OSTI)

    Chen, Yue; Zhang, Shunfen; Zhou, Tianyan; Huang, Chaoqun; McLaughlin, Alicia; Chen, Guangping

    2013-04-15

    Cytosolic sulfotransferases are one of the major families of phase II drug metabolizing enzymes. Sulfotransferase-catalyzed sulfonation regulates hormone activities, metabolizes drugs, detoxifies xenobiotics, and bioactivates carcinogens. Human dehydroepiandrosterone sulfotransferase (hSULT2A1) plays important biological roles by sulfating endogenous hydroxysteroids and exogenous xenobiotics. Genistein, mainly existing in soy food products, is a naturally occurring phytoestrogen with both chemopreventive and chemotherapeutic potential. Our previous studies have shown that genistein significantly induces hSULT2A1 in Hep G2 and Caco-2 cells. In this study, we investigated the roles of liver X receptor (LXRα) in the genistein induction of hSULT2A1. LXRs have been shown to induce expression of mouse Sult2a9 and hSULT2A1 gene. Our results demonstrate that LXRα mediates the genistein induction of hSULT2A1, supported by Western blot analysis results, hSULT2A1 promoter driven luciferase reporter gene assay results, and mRNA interference results. Chromatin immunoprecipitation (ChIP) assay results demonstrate that genistein increase the recruitment of hLXRα binding to the hSULT2A1 promoter. These results suggest that hLXRα plays an important role in the hSULT2A1 gene regulation. The biological functions of phytoestrogens may partially relate to their induction activity toward hydroxysteroid SULT. - Highlights: ► Liver X receptor α mediated genistein induction of hSULT2A1 in Hep G2 cells. ► LXRα and RXRα dimerization further activated this induction. ► Western blot results agreed well with luciferase reporter gene assay results. ► LXRs gene silencing significantly decreased hSULT2A1 expression. ► ChIP analysis suggested that genistein enhances hLXRα binding to the hSULT2A1 promoter.

  8. Plasmatic concentration of organochlorine lindane acts as metabolic disruptors in HepG2 liver cell line by inducing mitochondrial disorder

    SciTech Connect (OSTI)

    Benarbia, Mohammed el Amine; Macherel, David; Faure, Sbastien; Jacques, Caroline; Andriantsitohaina, Ramaroson; Malthiry, Yves

    2013-10-15

    Lindane (LD) is a persistent environmental pollutant that has been the subject of several toxicological studies. However, concentrations used in most of the reported studies were relatively higher than those found in the blood of the contaminated area residents and effects of low concentrations remain poorly investigated. Moreover, effects on cell metabolism and mitochondrial function of exposure to LD have received little attention. This study was designed to explore the effects of low concentrations of LD on cellular metabolism and mitochondrial function, using the hepatocarcinoma cell line HepG2. Cells were exposed to LD for 24, 48 and 72 h and different parameters linked with mitochondrial regulation and energy metabolism were analyzed. Despite having any impact on cellular viability, exposure to LD at plasmatic concentrations led to an increase of maximal respiratory capacity, complex I activity, intracellular ATP and NO release but decreased uncoupled respiration to ATP synthesis and medium lactate levels. In addition, LD exposure resulted in the upregulation of mitochondrial biogenesis genes. We suggest that, at plasmatic concentrations, LD acts as a metabolic disruptor through impaired mitochondrial function and regulation with an impact on cellular energetic metabolism. In addition, we propose that a cellular assay based on the analysis of mitochondria function, such as described here for LD, may be applicable for larger studies on the effects of low concentrations of xenobiotics, because of the exquisite sensitivity of this organelle. - Highlights: Our data clearly demonstrated in HepG2 cells that exposure at plasmatic low concentrations of LD were able to: Impair mitochondrial function Caused alteration on nucleo-mitochondrial cross-talk Increase nitric oxide release and protein nitration Impair cellular energetic metabolism and lipid accumulation.

  9. Geothermal Literature Review At Medicine Lake Geothermal Area...

    Open Energy Info (EERE)

    navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Geothermal Literature Review At Medicine Lake Geothermal Area (1984) Exploration Activity Details Location...

  10. 2015 DOE Annual Occupational Medicine Workshop & Webinar (OMWW) - March

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    16-17, 2015 | Department of Energy DOE Annual Occupational Medicine Workshop & Webinar (OMWW) - March 16-17, 2015 2015 DOE Annual Occupational Medicine Workshop & Webinar (OMWW) - March 16-17, 2015 December 18, 2014 - 3:13pm Addthis 2015 DOE Annual Occupational Medicine Workshop & Webinar (OMWW) - March 16-17, 2015 The DOE Annual Occupational Medicine Workshop & Webinar (OMWW) is a valuable training opportunity established by the Office of Health, Safety, and Security in

  11. Therapeutic potential of nanoceria in regenerative medicine

    SciTech Connect (OSTI)

    Das, Soumen; Chigurupati, Srinivasulu; Dowding, Janet; Munusamy, Prabhakaran; Baer, Donald R.; McGinnis, James F.; Mattson, Mark P.; Self, William; Seal, Sudipta

    2014-11-01

    Tissue engineering and regenerative medicine aim to achieve functional restoration of tissue or cells damaged through disease, aging or trauma. Advancement of tissue engineering requires innovation in the field of 3D scaffolding, and functionalization with bioactive molecules. Nanotechnology offers advanced materials with patterned nano-morphologies for cell growth and different molecular substrates which can support cell survival and functions. Cerium oxide nanoparticles (nanoceria) can control intracellular as well as extracellular reactive oxygen and nitrogen species. Recent findings suggest that nanoceria can enhance long-term cell survival, enable cell migration and proliferation, and promote stem cell differentiation. Moreover, the self-regenerative property of nanoceria permits a small dose to remain catalytically active for extended time. This review summarizes the possibilities and applications of nanoceria in the field of tissue engineering and regenerative medicine.

  12. PRIVACY IMPACT ASSESSMENT: OCCUPATIONAL MEDICINE- INL OCCUPATIONAL

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    OCCUPATIONAL MEDICINE- INL OCCUPATIONAL MEDICAL SUVEILLANCE SYSTEM (OMSS) PIA Template Version 3 - May, 2009 Department of Energy Privacy Impact Assessment (PIA) Guidance is provided in the template. See DOE Order 206.1, Department of Energy Privacy Program, Appendix A, Privacy Impact Assessments, for requirements and additional guidance for conducting a PIA: http://www.directives.doe.gov/pdfs/doe/doetextlneword/206/o2061.pdf Please complete electronically: no hand-written submissions will be

  13. PRIVACY IMPACT ASSESSMENT: Occupational Medicine Assistant PIA

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Medicine - Assistant PIA Template Version 3 - May, 2009 Department of Energy Privacy Impact Assessment (PIA) Guidance is provided in the template. See DOE Order 206.1, Deparlment of Energy Privacy Program, Appendix A, Privacy Impact Assessments, for requirements and additional guidance for conducting a PIA: http://www.directives.doe.gov/pdfs/doe/doetextlneword/206/o2061.pdf Please complete electronically: no hand-written submissions will be accepted. This template may not be modified. MODULE 1-

  14. Integrative Genomics and Computational Systems Medicine

    SciTech Connect (OSTI)

    McDermott, Jason E.; Huang, Yufei; Zhang, Bing; Xu, Hua; Zhao, Zhongming

    2014-01-01

    The exponential growth in generation of large amounts of genomic data from biological samples has driven the emerging field of systems medicine. This field is promising because it improves our understanding of disease processes at the systems level. However, the field is still in its young stage. There exists a great need for novel computational methods and approaches to effectively utilize and integrate various omics data.

  15. Converting Energy to Medical Progress [Nuclear Medicine

    DOE R&D Accomplishments [OSTI]

    2001-04-01

    For over 50 years the Office of Biological and Environmental Research (BER) of the United States Department of Energy (DOE) has been investing to advance environmental and biomedical knowledge connected to energy. The BER Medical Sciences program fosters research to develop beneficial applications of nuclear technologies for medical diagnosis and treatment of many diseases. Today, nuclear medicine helps millions of patients annually in the United States. Nearly every nuclear medicine scan or test used today was made possible by past BER-funded research on radiotracers, radiation detection devices, gamma cameras, PET and SPECT scanners, and computer science. The heart of biological research within BER has always been the pursuit of improved human health. The nuclear medicine of tomorrow will depend greatly on today's BER-supported research, particularly in the discovery of radiopharmaceuticals that seek specific molecular and genetic targets, the design of advanced scanners needed to create meaningful images with these future radiotracers, and the promise of new radiopharmaceutical treatments for cancers and genetic diseases.

  16. 2015 DOE Annual Occupational Medicine Workshop and Webinar (OMWW) |

    Energy Savers [EERE]

    Department of Energy 15 DOE Annual Occupational Medicine Workshop and Webinar (OMWW) 2015 DOE Annual Occupational Medicine Workshop and Webinar (OMWW) March 16-17, 2015 DOE Annual Occupational Medicine Workshop and Webinar (OMWW): Registration, Directions, Lodging, and Access REGISTRATION AND CONFERENCE SYSTEM The 2015 DOE Annual OMWW will be held March 16-17 in the Small Auditorium on the ground floor of the DOE Headquarters Forrestal Building in Washington, DC. Registration for the 2015

  17. DOE Research and Development Accomplishments Nobels in Medicine...

    Office of Scientific and Technical Information (OSTI)

    Nobels in Medicine Associated with the DOE and Predecessors Information about affiliations: Office of Science DOE Nobel Laureates Alphabetical Listing Chronological Listing A B C D ...

  18. National Library of Medicine Web Resources for Student Health Professionals

    SciTech Connect (OSTI)

    Womble, R.

    2010-04-02

    Familiarize students affiliated with the Student National Medical Association with the National Library of Medicine's online resources that address medical conditions, health disparities, and public health preparedness needs.

  19. Stepout-Deepening Wells At Medicine Lake Area (Warpinski, Et...

    Open Energy Info (EERE)

    2) Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Exploration Activity: Stepout-Deepening Wells At Medicine Lake Area (Warpinski, Et Al., 2002) Exploration Activity...

  20. The role of general nuclear medicine in breast cancer

    SciTech Connect (OSTI)

    Greene, Lacey R; Wilkinson, Deborah

    2015-03-15

    The rising incidence of breast cancer worldwide has prompted many improvements to current care. Routine nuclear medicine is a major contributor to a full gamut of clinical studies such as early lesion detection and stratification; guiding, monitoring, and predicting response to therapy; and monitoring progression, recurrence or metastases. Developments in instrumentation such as the high-resolution dedicated breast device coupled with the diagnostic versatility of conventional cameras have reinserted nuclear medicine as a valuable tool in the broader clinical setting. This review outlines the role of general nuclear medicine, concluding that targeted radiopharmaceuticals and versatile instrumentation position nuclear medicine as a powerful modality for patients with breast cancer.

  1. Biology and Medicine Division annual report, 1985

    SciTech Connect (OSTI)

    Not Available

    1986-04-01

    This book briefly describes the activities of the Biology and Medicine Division of the Lawrence Berkeley Laboratory. During the past year the Donner Pavilion program on the treatment of arteriovenous malformations in the brain has chalked up very significant successes. The disease control rate has been high and objective measures of success using cerebral angiography have been established. The new high resolution positron emitting tomographic imager has been demonstrated to operate successfully. In the Radiation Biophysics program, the availability of higher mass ions up to uranium has allowed us cell and tissue studies in a radiation domain that is entirely new. Using uranium beams, investigators have already made new and exciting findings that are described in the body of the report.

  2. Homeland Security and Emergency Management Coordination (HSEMC...

    National Nuclear Security Administration (NNSA)

    Blog Home About Us Our Programs ... The Office of Emergency Management assists the NNSA and Department of Energy sites in ... the NNSA Emergency Management System (EMS). ...

  3. NAMP Participates in Homeland Security Exercise

    Broader source: Energy.gov [DOE]

    CARLSBAD, N.M. – A program led by EM’s Carlsbad Field Office (CBFO) that coordinates analytical capabilities throughout DOE for response to potential national radiological incidents participated in a multi-agency exercise that simulated emergency response scenarios in Denver and Chicago.

  4. Reimbursable Work for Department of Homeland Security

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-04-21

    This revised Notice contains additional information and direction to cognizant DOE contracting officers and other affected Federal and contractor personnel identifying the processes and requirements to ensure the efficient implementation of the MOA. DOE N 251.62, dated 04-21-05, extends this directive until 4-21-06. Cancels DOE N 481.1.

  5. Germanium detectors in homeland security at PNNL

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Stave, S.

    2015-05-01

    Neutron and gamma-ray detection is used for non-proliferation and national security applications. While lower energy resolution detectors such as NaI(Tl) have their place, high purity germanium (HPGe) also has a role to play. A detection with HPGe is often a characterization due to the very high energy resolution. However, HPGe crystals remain small and expensive leaving arrays of smaller crystals as an excellent solution. PNNL has developed two similar HPGe arrays for two very different applications. One array, the Multisensor Aerial Radiation Survey (MARS) detector is a fieldable array that has been tested on trucks, boats, and helicopters. The CASCADESmore » HPGe array is an array designed to assay samples in a low background environment. The history of HPGe arrays at PNNL and the development of MARS and CASCADES will be detailed in this paper along with some of the other applications of HPGe at PNNL.« less

  6. Germanium detectors in homeland security at PNNL

    SciTech Connect (OSTI)

    Stave, S.

    2015-05-01

    Neutron and gamma-ray detection is used for non-proliferation and national security applications. While lower energy resolution detectors such as NaI(Tl) have their place, high purity germanium (HPGe) also has a role to play. A detection with HPGe is often a characterization due to the very high energy resolution. However, HPGe crystals remain small and expensive leaving arrays of smaller crystals as an excellent solution. PNNL has developed two similar HPGe arrays for two very different applications. One array, the Multisensor Aerial Radiation Survey (MARS) detector is a fieldable array that has been tested on trucks, boats, and helicopters. The CASCADES HPGe array is an array designed to assay samples in a low background environment. The history of HPGe arrays at PNNL and the development of MARS and CASCADES will be detailed in this paper along with some of the other applications of HPGe at PNNL.

  7. Pathways, Networks and Systems Medicine Conferences

    SciTech Connect (OSTI)

    Nadeau, Joseph H.

    2013-11-25

    The 6th Pathways, Networks and Systems Medicine Conference was held at the Minoa Palace Conference Center, Chania, Crete, Greece (16-21 June 2008). The Organizing Committee was composed of Joe Nadeau (CWRU, Cleveland), Rudi Balling (German Research Centre, Brauschweig), David Galas (Institute for Systems Biology, Seattle), Lee Hood (Institute for Systems Biology, Seattle), Diane Isonaka (Seattle), Fotis Kafatos (Imperial College, London), John Lambris (Univ. Pennsylvania, Philadelphia),Harris Lewin (Univ. of Indiana, Urbana-Champaign), Edison Liu (Genome Institute of Singapore, Singapore), and Shankar Subramaniam (Univ. California, San Diego). A total of 101 individuals from 21 countries participated in the conference: USA (48), Canada (5), France (5), Austria (4), Germany (3), Italy (3), UK (3), Greece (2), New Zealand (2), Singapore (2), Argentina (1), Australia (1), Cuba (1), Denmark (1), Japan (1), Mexico (1), Netherlands (1), Spain (1), Sweden (1), Switzerland (1). With respect to speakers, 29 were established faculty members and 13 were graduate students or postdoctoral fellows. With respect to gender representation, among speakers, 13 were female and 28 were male, and among all participants 43 were female and 58 were male. Program these included the following topics: Cancer Pathways and Networks (Day 1), Metabolic Disease Networks (Day 2), Day 3 ? Organs, Pathways and Stem Cells (Day 3), and Day 4 ? Inflammation, Immunity, Microbes and the Environment (Day 4). Proceedings of the Conference were not published.

  8. Medicine Lake, Minnesota: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    Hide Map This article is a stub. You can help OpenEI by expanding it. Medicine Lake is a city in Hennepin County, Minnesota. It falls under Minnesota's 3rd...

  9. Biology and Medicine Division annual report, 1982-1983

    SciTech Connect (OSTI)

    Not Available

    1984-04-01

    This annual report presents brief summaries of research activities during 1982 to 1983. Program activities have been individually entered into EDB. They include research medicine, radiosurgery, environmental physiology, radiation biophysics, and structural biophysics. (ACR)

  10. September 2013 Most Viewed Documents for Biology And Medicine...

    Office of Scientific and Technical Information (OSTI)

    September 2013 Most Viewed Documents for Biology And Medicine Science Subject Feed Drug ... KRISHNA,C.R. (1999) 27 > Site-Directed Research and Development FY 2012 Annual Report , ...

  11. IntroHEP-compressed.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ASCR Facility Plans --- 1 --- June 1 0, 2 015 Projections on Moore's Law and other trends Figure c ourtesy o f Kunle O lukotun, Lance H ammond, H erb S u=er, a nd Burton S mith, 2 004 2 0 1 10 100 1000 10000 100000 1000000 10000000 1970 1975 1980 1985 1990 1995 2000 2005 2010 Transistors (Thousands) Frequency (MHz) Power (W) Cores 1.E+01 1.E+02 1.E+03 1.E+04 1.E+05 1.E+06 1.E+07 1/1/1992 1/1/1996 1/1/2000 1/1/2004 1/1/2008 1/1/2012 1/1/2016 1/1/2020 1/1/2024 Energy per Flop (pJ) Heavyweight

  12. HEP BPI QCI Testing Reminders

    Energy Savers [EERE]

    HEAT Loan Minimum Standards and Requirements HEAT Loan Minimum Standards and Requirements Presents additional resources on loan standards and requirements from Elise Avers' presentation on HEAT Loan Minimum Standards and Requirements. PDF icon Minimum Standards and Requirements More Documents & Publications Building America Best Practices Series Vol. 14: Energy Renovations - HVAC: A Guide for Contractors to Share with Homeowners STEP Financial Incentives Summary Energy Saver 101: Home

  13. COMP-1h.EPS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Tents Tires Toilet seats Tool boxes Tool racks Toothbrushes Toothpaste Transparent tape Trash bags TV cabinets Umbrellas Unbreakable dishes Upholstery Vaporizers Vinyl flooring...

  14. COMP-1h.EPS

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Ballpoint pens Bandages Beach umbrellas Boats Cameras Candles Candies and gum Car battery cases Car enamel Cassettes Caulking CDscomputer disks Cellular phones Clothesline Coffee ...

  15. Physics in medicine and biology encyclopedia 2-volume set

    SciTech Connect (OSTI)

    McAinsh, T.F.

    1986-01-01

    The Physics in Medicine and Biology Encyclopedia provides in two volumes a review of a wide range of topics of current interest in medical physics, bioengineering and biophysics. The Encyclopedia is extensively cross-referenced, indexed and illustrated, and all articles are complete with fully verified bibliographies. A glossary gives full details of specialized terms appearing in the Encyclopedia.

  16. Dictionary/handbook of nuclear medicine and clinical imaging

    SciTech Connect (OSTI)

    Iturralde, M.P. )

    1989-01-01

    This book covers the following topics: Fundamentals of English medical etymology, Abbreviations, acronyms, symbols, denotations, and signs commonly used or defined in the dictionary, Characteristics of the elements, Characteristics of practicable radioisotopes and of selected radionuclides commonly used in nuclear medicine, Properties and production of radionuclides, Radioactive decay, Radiopharmaceuticals, and Radiation dosimetry.

  17. EIS-0432: Medicine Bow Fuel & Power Coal-to-Liquid Facility in...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2: Medicine Bow Fuel & Power Coal-to-Liquid Facility in Carbon County, WY EIS-0432: Medicine Bow Fuel & Power Coal-to-Liquid Facility in Carbon County, WY Documents Available for ...

  18. ORISE: Advanced Radiation Medicine | REAC/TS Continuing Medical Education

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Course Advanced Radiation Medicine Dates Scheduled Register Online August 15-19, 2016 Fee: $275 Maximum enrollment: 28 30 hours AMA PRA Category 1 Credits(tm) This 4½-day course includes more advanced information for medical practitioners. This program is academically more rigorous than the REM course and is primarily for Physicians, Physician Assistants, Nurse Practitioners, and Nurses desiring an advanced level of information on the diagnosis and management of ionizing radiation injuries

  19. ORISE: Radiation Emergency Medicine - Continuing Medical Education Course

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Radiation Emergency Medicine Dates Scheduled Register Online June 14-17, 2016 August 9-12, 2016 Fee: $200 Maximum enrollment: 24 24.5 hours AMA PRA Category 1 Credits(tm) This 3½-day course is intended for Physicians, Physician Assistants, Nurse Practitioners, Nurses and other healthcare providers. First responders, emergency management, and public health professionals may find the course beneficial. The course emphasizes the practical aspects of initial hospital management of irradiated and/or

  20. CHRONOLOGY OF EVENTS IN DIVISION OF BIOLOGY AND MEDICINE PROGRAMS

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    CHRONOLOGY OF EVENTS IN DIVISION OF BIOLOGY AND MEDICINE PROGRAMS 1927 1936 December 1944 1946 August 1947 Discovery of the specific mutagenic effects of ionizing radiation by Muller. First cyclotron-produced radioisotope, phosphorus 32, administered to a patient suffering from leukemia at University of California, Berkeley. Initiation of first large scale mammalian genetics study (in mice) at the University of Rochester. First shipment of reactor-produced radioisotope, carbon 14, to independent

  1. Equal Access Initiative: HIV/AIDS Information Resources from the National Library of Medicine

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Equal Access Initiative: HIV/AIDS Information Resources from the National Library of Medicine Instructors: Nicole Dancy, National Library of Medicine Wilma Templin-Branner, Oak Ridge Institute for Science and Education For Grantees of National Minority AIDS Council 2010 Equal Access Initiative Computer Grants Program United States Conference on AIDS September 11, 2010 2 Purpose  To familiarize participants with reliable online health information from the National Library of Medicine and other

  2. Core Analysis At Medicine Lake Area (Clausen Et Al, 2006) | Open...

    Open Energy Info (EERE)

    Lisle, 1995; Nemcok and Gayer, 1996). References Steven Clausen, Michal Nemcok, Joseph Moore, Jeffrey Hulen, John Bartley (2006) Mapping Fractures In The Medicine Lake Geothermal...

  3. Flexible nuclear medicine camera and method of using

    DOE Patents [OSTI]

    Dilmanian, F. Avraham; Packer, Samuel; Slatkin, Daniel N.

    1996-12-10

    A nuclear medicine camera 10 and method of use photographically record radioactive decay particles emitted from a source, for example a small, previously undetectable breast cancer, inside a patient. The camera 10 includes a flexible frame 20 containing a window 22, a photographic film 24, and a scintillation screen 26, with or without a gamma-ray collimator 34. The frame 20 flexes for following the contour of the examination site on the patient, with the window 22 being disposed in substantially abutting contact with the skin of the patient for reducing the distance between the film 24 and the radiation source inside the patient. The frame 20 is removably affixed to the patient at the examination site for allowing the patient mobility to wear the frame 20 for a predetermined exposure time period. The exposure time may be several days for obtaining early qualitative detection of small malignant neoplasms.

  4. Flexible nuclear medicine camera and method of using

    DOE Patents [OSTI]

    Dilmanian, F.A.; Packer, S.; Slatkin, D.N.

    1996-12-10

    A nuclear medicine camera and method of use photographically record radioactive decay particles emitted from a source, for example a small, previously undetectable breast cancer, inside a patient. The camera includes a flexible frame containing a window, a photographic film, and a scintillation screen, with or without a gamma-ray collimator. The frame flexes for following the contour of the examination site on the patient, with the window being disposed in substantially abutting contact with the skin of the patient for reducing the distance between the film and the radiation source inside the patient. The frame is removably affixed to the patient at the examination site for allowing the patient mobility to wear the frame for a predetermined exposure time period. The exposure time may be several days for obtaining early qualitative detection of small malignant neoplasms. 11 figs.

  5. Biology and Medicine Division annual report, 1981-1982. [Lead abstract

    SciTech Connect (OSTI)

    Not Available

    1983-04-01

    Separate abstracts were prepared for the 61 research reports in the 1981-1982 annual report for the Biology and Medicine Division of the Lawrence Berkeley Laboratory. Programs reviewed include research medicine, Donner Pavilion, environmental physiology, radiation biophysics and structural biophysics. (KRM)

  6. Ernest Orlando Lawrence (1901-1958), Cyclotron and Medicine

    SciTech Connect (OSTI)

    Chu, William T.

    2005-09-01

    On August 8, 2001, Lawrence Berkeley National Laboratory celebrated the centennial of the birth of its founder (and namesake), Ernest Orlando Lawrence. For the occasion, many speeches were given and old speeches were remembered. We recall the words of the late Luis Alvarez, a Nobel Laureate and one of the Lawrence's closest colleagues: ''Lawrence will always be remembered as the inventor of the cyclotron, but more importantly, he should be remembered as the inventor of the modern way of doing science''. J. L. Heilbron and R. W. Seidel, in the introduction of their book, ''Lawrence and His Laboratory'' stated, ''The motives and mechanisms that shaped the growth of the Laboratory helped to force deep changes in the scientific estate and in the wider society. In the entrepreneurship of its founder, Ernest Orlando Lawrence, these motives, mechanisms, and changes came together in a tight focus. He mobilized great and small philanthropists, state and local governments, corporations, and plutocrats, volunteers and virtuosos. The work they supported, from astrophysics and atomic bombs, from radiochemistry to nuclear medicine, shaped the way we observe, control, and manipulate our environment.'' Indeed, all over the civilized world, the ways we do science changed forever after Lawrence built his famed Radiation Laboratory. In this editorial, we epitomize his legacy of changing the way we do medicine, thereby affecting the health and well being of all humanity. This year marks the 75th anniversary of the invention of the cyclotron by Ernest Orlando Lawrence at the University of California at Berkeley. Lawrence conceived the idea of the cyclotron early in 1929 after reading an article by Rolf Wideroe on high-energy accelerators. In the spring of 1930 one of his students, Nels Edlefsen, constructed two crude models of a cyclotron. Later in the fall of the same year, another student, M. Stanley Livingston, constructed a 13-cm diameter model that had all the features of early cyclotrons, accelerating protons to 80,000 volts using less than 1,000 volts on a semi-circular accelerating electrode, now called the ''dee''. Following the discovery by J. D. Cockcroft and E. T. S. Walton of how to produce larger currents at higher voltages, Lawrence constructed the first two-dee 27-Inch (69-cm) Cyclotron, which produced protons and deuterons of 4.8 MeV. The 27-Inch Cyclotron was used extensively in early investigations of nuclear reactions involving neutrons and artificial radioactivity. In 1939, working with William Brobeck, Lawrence constructed the 60-Inch (150-cm) Cyclotron, which accelerated deuterons to 19 MeV. It was housed in the Crocker Laboratory, where scientists first made transmutations of some elements, discovered several transuranic elements, and created hundreds of radioisotopes of known elements. At the Crocker Laboratory the new medical modality called nuclear medicine was born, which used radioisotopes for diagnosis and treatment of human diseases. In 1939 Lawrence was awarded the Nobel Prize in Physics, and later element 103 was named ''Lawrencium'' in his honor.

  7. Monte Carlo Simulations for Homeland Security Using Anthropomorphic Phantoms

    SciTech Connect (OSTI)

    Burns, Kimberly A.

    2008-01-01

    A radiological dispersion device (RDD) is a device which deliberately releases radioactive material for the purpose of causing terror or harm. In the event that a dirty bomb is detonated, there may be airborne radioactive material that can be inhaled as well as settle on an individuals leading to external contamination.

  8. Homeland Security Presidential Directive HSPD-7 (December 17...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    PDF icon HSPD-7.pdf More Documents & Publications National Infrastructure Protection Plan DOE O 206.2 Identity, Credential, and Access Management (ICAM) Energy Emergency ...

  9. Before the Senate Homeland Security and Governmental Affairs...

    Energy Savers [EERE]

    Office of Procurement and Assistance Management, Office of Management Subject: Cost-Plus Award Fee PDF icon 8-3-09FinalTestimony(Simpson).pdf More Documents & Publications...

  10. National Atmospheric Release Advisory Center (NARAC) Capabilities for Homeland Security

    SciTech Connect (OSTI)

    Sugiyama, G; Nasstrom, J; Baskett, R; Simpson, M

    2010-03-08

    The Department of Energy's National Atmospheric Release Advisory Center (NARAC) provides critical information during hazardous airborne releases as part of an integrated national preparedness and response strategy. Located at Lawrence Livermore National Laboratory, NARAC provides 24/7 tools and expert services to map the spread of hazardous material accidentally or intentionally released into the atmosphere. NARAC graphical products show affected areas and populations, potential casualties, and health effect or protective action guideline levels. LLNL experts produce quality-assured analyses based on field data to assist decision makers and responders. NARAC staff and collaborators conduct research and development into new science, tools, capabilities, and technologies in strategically important areas related to airborne transport and fate modeling and emergency response. This paper provides a brief overview of some of NARAC's activities, capabilities, and research and development.

  11. Department of Homeland Security, Science and Technology Directorate...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... solutions for air, land, and maritime borders along ... its energy-such as coal, natural gas, and oil-renewable energy ... refueling * Mobility requirements A number of ...

  12. Before the Senate Homeland Security and Governmental Affairs...

    Broader source: Energy.gov (indexed) [DOE]

    and International Security By: Richard Kidd, Program Manager Federal Energy Management Program, Office of Energy Efficiency and Renewable Energy Subject: Cutting the Federal...

  13. Indiana Department of Homeland Security - NNPP Exercise | Department of

    Office of Environmental Management (EM)

    Department of Energy Special Study, Department of Energy - August 2003 Independent Oversight Special Study, Department of Energy - August 2003 August 2003 Special Study of the Department of Energy's Management of Suspect/Counterfeit Items This report provides the results of a special study of the U.S. Department of Energy's (DOE) management of suspect/counterfeit items. The study was conducted from May through August 2003 by the DOE Office of Independent Oversight and Performance Assurance

  14. How ORISE is Making a Difference: Homeland Security

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Microgrids Work How Microgrids Work June 17, 2014 - 10:27am Addthis Microgrid equipment at the National Wind Technology Center in Colorado. | Photo courtesy of the National Renewable Energy Lab. Microgrid equipment at the National Wind Technology Center in Colorado. | Photo courtesy of the National Renewable Energy Lab. Allison Lantero Allison Lantero Digital Content Specialist, Office of Public Affairs How can I participate? Join us today for our microgrids Twitter Office Hours at 2 p.m. ET,

  15. PNNLs Data Intensive Computing research battles Homeland Security threats

    ScienceCinema (OSTI)

    David Thurman; Joe Kielman; Katherine Wolf; David Atkinson

    2012-12-31

    The Pacific Northwest National Laboratorys (PNNL's) approach to data intensive computing (DIC) is focused on three key research areas: hybrid hardware architecture, software architectures, and analytic algorithms. Advancements in these areas will help to address, and solve, DIC issues associated with capturing, managing, analyzing and understanding, in near real time, data at volumes and rates that push the frontiers of current technologies.

  16. Notices DEPARTMENT OF HOMELAND SECURITY Federal Emergency Management

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Agency Docket ID FEMA-2015-0006 Guidelines for Implementing Executive Order 11988, Floodplain Management, and Executive Order 13690, Establishing a Federal Flood Risk ...

  17. EIS-0432: Medicine Bow Fuel & Power Coal-to-Liquid Facility in Carbon

    Energy Savers [EERE]

    County, WY | Department of Energy 2: Medicine Bow Fuel & Power Coal-to-Liquid Facility in Carbon County, WY EIS-0432: Medicine Bow Fuel & Power Coal-to-Liquid Facility in Carbon County, WY Documents Available for Download November 27, 2009 EIS-0432: Notice of Intent to Prepare an Environmental Impact Statement Federal Loan Guarantee to Support the Construction and Startup of the Medicine Bow Fuel & Power Coal-to-Liquid Facility in Carbon County, Wyoming December 16, 2009

  18. FES BER HEP NP BES ASCR

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    fracture networks improve reliability & economics of renewable geothermal energy. (Melior ... fracture networks improve reliability & economics of renewable geothermal energy. ...

  19. HEP/NP Requirements Review 2013

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    NP Program Offices. These requirements will serve as input to the ESnet architecture and planning processes, and will help ensure that ESnet continues to provide world-class...

  20. nersc-for-hep-theory.pptx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ph.D. NERSC User Services High Performance Computing and Big Data at NERSC --- 1 --- April 3 , 2 013 Outline * What i s N ERSC? * Who r uns a t N ERSC? * Can y ou u sedo y ou n ...

  1. Symposium on Data Preservation in HEP

    ScienceCinema (OSTI)

    None

    2011-10-06

    1. A view point on data preservation in High Energy Physics by Rolf Heuer 2. Results from the PARSE.Insight project by Salvatore Mele 3. The ICFA-DPHEP study group by Cristinel Diaconu 4. Discussion

  2. Microsoft Word - HEP2017_FINAL.docx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Large Scale Computing and Storage Requirements for High Energy Physics: Target 2017 21 Figure 1 Historical usage ... We plan to do many such simulations to create a library of ...

  3. FES BER HEP NP BES ASCR

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    December 2015 NERSC Science Highlights Science Highlights December 2015 Chemistry Simula'ons run at NERSC lead to the predic'on of a new phase of superionic ice, a special form of ice that could exist on Uranus and Neptune (Roberto Car , Princeton U., Nature Comm.) Fusion Energy 3D simula'ons run at NERSC help gain new insights into fusion plasma behavior that will improve the ability to stabilize a tokamak reactor (S. Jardin , Princeton Plasma Physics Lab, Phys. Rev. Lett.) High Energy &

  4. Microsoft Word - HEP2017_FINAL.docx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... number generation and Fourierspherical harmonic transforms) and map-making (requiring a ... To combat this we usually use a spatial grid with coarse resolution (relative to the ...

  5. Fermilab at Work | Physics Links: HEP Labs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Linear Accelerator Center LNS at Cornell University CERN (Geneva, Switzerland) DESY (Hamburg, Germany) KEK (Tsukuba, Japan) JINR (Dubna, Russia) JLab ANL (High Energy Physics) LBL...

  6. Cancer Research Center Indiana University School of Medicine

    SciTech Connect (OSTI)

    Not Available

    1994-08-01

    The Department of Energy (DOE) proposes to authorize the Indiana School of Medicine to proceed with the detailed design, construction and equipping of the proposed Cancer Research Center (CRC). A grant was executed with the University on April 21, 1992. A four-story building with basement would be constructed on the proposed site over a 24-month period. The proposed project would bring together, in one building, three existing hematology/oncology basic research programs, with improved cost-effectiveness through the sharing of common resources. The proposed site is currently covered with asphaltic pavement and is used as a campus parking lot. The surrounding area is developed campus, characterized by buildings, walkways, with minimal lawns and plantings. The proposed site has no history of prior structures and no evidence of potential sources of prior contamination of the soil. Environmental impacts of construction would be limited to minor increases in traffic, and the typical noises associated with standard building construction. The proposed CRC project operation would involve the use radionuclides and various hazardous materials in conducting clinical studies. Storage, removal and disposal of hazardous wastes would be managed under existing University programs that comply with federal and state requirements. Radiological safety programs would be governed by Nuclear Regulatory Commission (NRC) license and applicable Environmental Protection Agency (EPA) regulations. There are no other NEPA reviews currently active which are in relationship to this proposed site. The proposed project is part of a Medical Campus master plan and is consistent with applicable local zoning and land use requirements.

  7. Nuclear Medicine at Berkeley Lab: From Pioneering Beginnings to Today (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Budinger, Thomas [LBNL, Center for Functional Imaging

    2011-10-04

    Summer Lecture Series 2006: Thomas Budinger, head of Berkeley Lab's Center for Functional Imaging, discusses Berkeley Lab's rich history pioneering the field of nuclear medicine, from radioisotopes to medical imaging.

  8. Software optimized on Mira advances design of mini-proteins for medicines,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    materials | Argonne Leadership Computing Facility Software optimized on Mira advances design of mini-proteins for medicines, materials Author: Katie Jones February 13, 2016 Facebook Twitter LinkedIn Google E-mail Printer-friendly version Scientists at the University of Washington are using Mira to virtually design unique, artificial peptides, or short proteins. Peptides have the best properties of two different classes of medical drugs today and could enable future, peptide-based medicines

  9. New Technology Paves Way for Highly Sensitive Photodetectors with

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Applications in High Energy Physics, Medicine, and National Security | U.S. DOE Office of Science (SC) New Technology Paves Way for Highly Sensitive Photodetectors with Applications in High Energy Physics, Medicine, and National Security High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000

  10. Development of taste sensor system for differentiation of Indonesian herbal medicines

    SciTech Connect (OSTI)

    Kaltsum, U.; Triyana, K. Siswanta, D.

    2014-09-25

    In Indonesia, herbal medicines are usually produced by small and medium enterprises which are relatively low in quality control. The purpose of this paper is to report that we have developed a taste sensor system with global selectivity, i.e., electronic tongue (e-tongue) for differentiation of Indonesian herbal medicines. The e-tongue was composed of five kinds of ion selective electrodes as working electrodes, data acquisition system, and pattern recognition system. Each ion selective electrode (ISE) was built by attaching lipid/polymer membrane. For this purpose, the five kinds of membranes were built by mixing lipid, plasticizer (nitrophenyl octyl ether/NPOE), polyvinyl chloride (PVC), and tetrahydrofuran (THF). In this study, we employed five kinds of lipid, namely oleic acid (OA), dioctyl phosphate (DOP), decyl alcohol (DA), dodecylamine (DDC), and trioctyl methyl ammonium chloride (TOMA). In this case, the membranes transform information of taste substances into electric signal. The five kinds of Indonesian herbal medicine were purchased from local supermarket in Yogyakarta, i.e., kunyit asam (made from turmeric and tamarind), beras kencur (made from rice and kencur), jahe wangi (made from ginger and fragrance), sirih wangi (made from betel leaf), and temulawak (made from Javanese ginger). Prior to detecting the taste from the Indonesian herbal medicine samples, each ion selective electrode was tested with five basic taste samples, i.e., for saltiness, sweetness, umami, bitterness, and sourness. All ISEs showed global selectivity to all samples. Furthermore, the array of ISEs showed specific response pattern to each Indonesian herbal medicine. For pattern recognition system, we employed principle component analysis (PCA). As a result, the e-tongue was able to differentiate five kinds of Indonesian herbal medicines, proven by the total variance of first and second principle components is about 93%. For the future, the e-tongue may be developed for quality control application in herbal medicine industries.

  11. Validation of in vitro cell models used in drug metabolism and transport studies; genotyping of cytochrome P450, phase II enzymes and drug transporter polymorphisms in the human hepatoma (HepG2), ovarian carcinoma (IGROV-1) and colon carcinoma (CaCo-2, LS180) cell lines

    SciTech Connect (OSTI)

    Brandon, Esther F.A.; Bosch, Tessa M.; Deenen, Maarten J.; Levink, Rianne; Wal, Everdina van der; Meerveld, Joyce B.M. van; Bijl, Monique; Beijnen, Jos H. |; Schellens, Jan H.M. |; Meijerman, Irma . E-mail: I.Meijerman@pharm.uu.nl

    2006-02-15

    Human cell lines are often used for in vitro biotransformation and transport studies of drugs. In vivo, genetic polymorphisms have been identified in drug-metabolizing enzymes and ABC-drug transporters leading to altered enzyme activity, or a change in the inducibility of these enzymes. These genetic polymorphisms could also influence the outcome of studies using human cell lines. Therefore, the aim of our study was to pharmacogenotype four cell lines frequently used in drug metabolism and transport studies, HepG2, IGROV-1, CaCo-2 and LS180, for genetic polymorphisms in biotransformation enzymes and drug transporters. The results indicate that, despite the presence of some genetic polymorphisms, no real effects influencing the activity of metabolizing enzymes or drug transporters in the investigated cell lines are expected. However, this characterization will be an aid in the interpretation of the results of biotransformation and transport studies using these in vitro cell models.

  12. HIV/AIDS Information Resources from the National Library of Medicine-STOP

    SciTech Connect (OSTI)

    Templin-Branner, W. and N. Dancy

    2010-06-15

    The HIV/AIDS Information Resources from the National Library of Medicine training is designed specifically for the UNCFSP HBCU Screening, Testing, Outreach, and Prevention (STOP) HIV/AIDS Program project members to provide valuable health information resources from the National Library of Medicine and other reliable sources to increase awareness of the wealth of treatment information and educational materials that are available on the Internet and to improve prevention and treatment education for their clients. These resources will also meet the needs of community-based organizations

  13. Interdisciplinary Dialogue for Education, Collaboration, and Innovation: Intelligent Biology and Medicine In and Beyond 2013

    SciTech Connect (OSTI)

    Zhang, Bing; Huang, Yufei; McDermott, Jason E.; Posey, Rebecca H.; Xu, Hua; Zhao, Zhongming

    2013-12-09

    The 2013 International Conference on Intelligent Biology and Medicine (ICIBM 2013) was held on August 11-13, 2013 in Nashville, Tennessee, USA. The conference included six scientific sessions, two tutorial sessions, one workshop, two poster sessions, and four keynote presentations that covered cutting-edge research topics in bioinformatics, systems biology, computational medicine, and intelligent computing. Here, we present a summary of the conference and an editorial report of the supplements to BMC Genomics and BMC Systems Biology that include 19 research papers selected from ICIBM 2013.

  14. DOE - Office of Legacy Management -- Long Island College of Medicine - NY

    Office of Legacy Management (LM)

    0-14 Long Island College of Medicine - NY 0-14 FUSRAP Considered Sites Site: Long Island College of Medicine (NY.0-14 ) Eliminated from consideration under FUSRAP Designated Name: Not Designated Alternate Name: None Location: New York , New York NY.0-14-1 Evaluation Year: 1987 NY.0-14-1 Site Operations: Performed research utilizing small quantities of radioactive materials in a controlled environment. NY.0-14-1 Site Disposition: Eliminated - Potential for contamination remote NY.0-14-1

  15. March 2016 Most Viewed Documents for Biology And Medicine | OSTI, US Dept

    Office of Scientific and Technical Information (OSTI)

    of Energy, Office of Scientific and Technical Information March 2016 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. [Brookhaven National Lab., Upton, NY (United States)]|[State Univ. of New York at Stony Brook, Stony Brook, NY (United States). Dept. of Psychiatry]; Fowler, J.S.; Logan, J.; Wang, G.J. [Brookhaven National Lab., Upton, NY (United States)] (1995) 206 Drug Retention Times Center for Human Reliability Studies

  16. April 2013 Most Viewed Documents for Biology And Medicine | OSTI, US Dept

    Office of Scientific and Technical Information (OSTI)

    of Energy, Office of Scientific and Technical Information April 2013 Most Viewed Documents for Biology And Medicine Science Subject Feed Publications in biomedical and environmental sciences programs, 1981 Moody, J.B. (comp.) (1982) 306 /> Drug Retention Times Center for Human Reliability Studies (2007) 99 /> SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE GENERATOR SETS. KRISHNA,C.R. (1999) 95 /> Defining the Effectiveness of UV Lamps Installed in Circulating Air Ductwork Douglas

  17. Caribbean Equal Access Program: HIV/AIDS Information Resources from the National Library of Medicine

    SciTech Connect (OSTI)

    Nancy Dancy, NLM, and Wilma Templin-Branner, ORISE

    2009-01-01

    As the treatment and management of HIV/AIDS continues to evolve with new scientific breakthroughs, treatment discoveries, and management challenges, it is difficult for people living with HIV/AIDS and those who care for them to keep up with the latest information on HIV/AIDS prevention, treatment, and research. The National Library of Medicine, of the National Institutes of Health, has a wealth of health information resources freely available on the Internet to address these needs.

  18. Diagnostic and therapeutic applications of diode lasers and solid state lasers in medicine

    SciTech Connect (OSTI)

    Jacques, S.L. . Cancer Center); Welch, A.J. ); Motamedi, M. . Medical Branch); Rastegar, S. ); Tittel, F. ); Esterowitz, L. )

    1992-05-01

    The Texas Medical Center in Houston and the nearby UT Medical Branch at Galveston together constitute a major center of medical research activities. Laser applications in medicine are under development with the engineering assistance of the colloborating engineering centers at Rice University, UT-Austin, and Texas A M Univ. In addition, this collective is collaborating with the Naval Research Laboratory, where new developments in laser design are underway, in order to transfer promising new laser technology rapidly into the medical environment.

  19. ORISE: Equal Access Initiative - HIV/AIDS Information Resources from the National Library of Medicine

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EQUAL ACCESS INITIATIVE: HIV/AIDS Information Resources from the National Library of Medicine A Training Course developed for the Grant Recipients of the National Minority AIDS Council 2010 Equal Access Initiative Computer Grants Presented at United States Conference on AIDS Orlando, Florida September 11, 2010 Disclaimer Every effort has been made to ensure that the screen graphics and the exercises in this document are up-to-date and accurate. However, due to the frequency of Web updates, they

  20. Structure of Chinese Herbal-based Medicine Captured by ATP on a Human tRNA

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Synthetase | Stanford Synchrotron Radiation Lightsource Structure of Chinese Herbal-based Medicine Captured by ATP on a Human tRNA Synthetase Thursday, October 31, 2013 For thousands of years the Chinese have been using the Chang Shan herb (Dichroa febrifuga Lour) to treat malaria-induced fevers (1). The active ingredient in the herb was eventually shown to be a small molecule known as febrifugine. A halogenated derivative of febrifugine, called halofuginone (HF), has been tested in clinical

  1. Diagnostic and therapeutic applications of diode lasers and solid state lasers in medicine. Progress report

    SciTech Connect (OSTI)

    Jacques, S.L.; Welch, A.J.; Motamedi, M.; Rastegar, S.; Tittel, F.; Esterowitz, L.

    1993-05-01

    The Texas Medical Center in Houston and the nearby UT Medical Branch at Galveston together constitute a major center of medical research activities. Laser applications in medicine are under development with the engineering assistance of the collaborating engineering enters at Rice University, UT-Austin, Texas A&M Univ. In addition, this collective is collaborating with the naval Research Laboratory, where new developments in laser design are underway, in order to transfer promising new laser technology rapidly into the medical environment.

  2. September 2013 Most Viewed Documents for Biology And Medicine | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy, Office of Scientific and Technical Information September 2013 Most Viewed Documents for Biology And Medicine Science Subject Feed Drug Retention Times Center for Human Reliability Studies (2007) 29 /> Oleoresin Capsicum toxicology evaluation and hazard review Archuleta, M.M. (1995) 27 /> SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE GENERATOR SETS. KRISHNA,C.R. (1999) 27 /> Site-Directed Research and Development FY 2012 Annual Report , (2013) 27 /> Human

  3. September 2015 Most Viewed Documents for Biology And Medicine | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy, Office of Scientific and Technical Information September 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. [Brookhaven National Lab., Upton, NY (United States)]|[State Univ. of New York at Stony Brook, Stony Brook, NY (United States). Dept. of Psychiatry]; Fowler, J.S.; Logan, J.; Wang, G.J. [Brookhaven National Lab., Upton, NY (United States)] (1995) 168 Drug Retention Times Center for Human Reliability

  4. January 2013 Most Viewed Documents for Biology And Medicine | OSTI, US Dept

    Office of Scientific and Technical Information (OSTI)

    of Energy, Office of Scientific and Technical Information January 2013 Most Viewed Documents for Biology And Medicine Nevada Test Site Radiological Control Manual Radiological Control Managers' Council Nevada Test Site Effects of ionizing radiation on the boreal forest: Canada's FIG experiment, with implications for radionuclides Amiro, B.D.; Sheppard, S.C Assessment of atmospheric metallic pollution in the metropolitan region of Sao Paulo, Brazil, employing Tillandsia usneoides L. as

  5. July 2013 Most Viewed Documents for Biology And Medicine | OSTI, US Dept of

    Office of Scientific and Technical Information (OSTI)

    Energy, Office of Scientific and Technical Information July 2013 Most Viewed Documents for Biology And Medicine Science Subject Feed Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) 51 /> SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE GENERATOR SETS. KRISHNA,C.R. (1999) 46 /> Human radiation studies: Remembering the early years. Oral history of Donner Lab Administrator Baird G. Whaley, August 15, 1994 NONE (1995)

  6. June 2014 Most Viewed Documents for Biology And Medicine | OSTI, US Dept of

    Office of Scientific and Technical Information (OSTI)

    Energy, Office of Scientific and Technical Information June 2014 Most Viewed Documents for Biology And Medicine Science Subject Feed Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files Randolph Schwarz; Leland L. Carter; Alysia Schwarz (2005) 37 /> Geothermal demonstration: Zunil food dehydration facility Maldonado, O. (Consultecnia, Guatemala City (Guatemala)); Altseimer, J.; Thayer, G.R. (Los Alamos National Lab., NM

  7. June 2015 Most Viewed Documents for Biology And Medicine | OSTI, US Dept of

    Office of Scientific and Technical Information (OSTI)

    Energy, Office of Scientific and Technical Information June 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. [Brookhaven National Lab., Upton, NY (United States)]|[State Univ. of New York at Stony Brook, Stony Brook, NY (United States). Dept. of Psychiatry]; Fowler, J.S.; Logan, J.; Wang, G.J. [Brookhaven National Lab., Upton, NY (United States)] (1995) 115 Dose and volume specification for reporting interstitial therapy

  8. March 2014 Most Viewed Documents for Biology And Medicine | OSTI, US Dept

    Office of Scientific and Technical Information (OSTI)

    of Energy, Office of Scientific and Technical Information 4 Most Viewed Documents for Biology And Medicine Science Subject Feed Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) 30 /> Dose and volume specification for reporting interstitial therapy NONE (1997) 29 /> Geothermal demonstration: Zunil food dehydration facility Maldonado, O. (Consultecnia, Guatemala City (Guatemala)); Altseimer, J.; Thayer, G.R. (Los

  9. Most Viewed Documents for Biology and Medicine: December 2014 | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy, Office of Scientific and Technical Information Most Viewed Documents for Biology and Medicine: December 2014 Dose and volume specification for reporting interstitial therapy NONE (1997) 38 Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files Randolph Schwarz; Leland L. Carter; Alysia Schwarz (2005) 38 Drug Retention Times Center for Human Reliability Studies (2007) 34 Degradation of high concentrations of

  10. Most Viewed Documents for Biology and Medicine: September 2014 | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy, Office of Scientific and Technical Information for Biology and Medicine: September 2014 Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided Design (CAD) Files Randolph Schwarz; Leland L. Carter; Alysia Schwarz (2005) 32 Dose and volume specification for reporting interstitial therapy NONE (1997) 28 Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) 27 Drug

  11. December 2015 Most Viewed Documents for Biology And Medicine | OSTI, US

    Office of Scientific and Technical Information (OSTI)

    Dept of Energy, Office of Scientific and Technical Information December 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. [Brookhaven National Lab., Upton, NY (United States)]|[State Univ. of New York at Stony Brook, Stony Brook, NY (United States). Dept. of Psychiatry]; Fowler, J.S.; Logan, J.; Wang, G.J. [Brookhaven National Lab., Upton, NY (United States)] (1995) 160 Drug Retention Times Center for Human Reliability

  12. TOXNET and Beyond: Using the National Library of Medicine's Environmental Health and Toxicology Portal

    SciTech Connect (OSTI)

    Templin-Branner, W.

    2010-10-20

    The National Library of Medicine's Environmental Health and Toxicology Portal provides access to numerous databases that can help you explore environmental chemicals and risks. TOXNET and Beyond: Using NLM's Environmental Health and Toxicology Portal conveys the fundamentals of searching the NLM's TOXNET system of databases in chemistry, toxicology, environmental health, and related fields. In addition to TOXNET, the course will highlight various resources available through the Environmental Health and Toxicology Portal.

  13. Software optimized on Mira advances design of mini-proteins for medicines,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    materials | Argonne National Laboratory Software optimized on Mira advances design of mini-proteins for medicines, materials By Katie Elyce Jones * February 12, 2016 Tweet EmailPrint When diseases like cancer and AIDS affect millions of people each year and rare but deadly infections like Ebola move faster than treatment, the race to make effective drugs becomes a sprint. That's why University of Washington (UW) researchers are using one of the nation's most powerful supercomputers, the

  14. TECTONIC VERSUS VOLCANIC ORIGIN OF THE SUMMIT DEPRESSION AT MEDICINE LAKE VOLCANO, CALIFORNIA

    SciTech Connect (OSTI)

    Mark Leon Gwynn

    2010-05-01

    Medicine Lake Volcano is a Quaternary shield volcano located in a tectonically complex and active zone at the transition between the Basin and Range Province and the Cascade Range of the Pacific Province. The volcano is topped by a 7x12 km elliptical depression surrounded by a discontinuous constructional ring of basaltic to rhyolitic lava flows. This thesis explores the possibility that the depression may have formed due to regional extension (rift basin) or dextral shear (pull-apart basin) rather than through caldera collapse and examines the relationship between regional tectonics and localized volcanism. Existing data consisting of temperature and magnetotelluric surveys, alteration mineral studies, and core logging were compiled and supplemented with additional core logging, field observations, and fault striae studies in paleomagnetically oriented core samples. These results were then synthesized with regional fault data from existing maps and databases. Faulting patterns near the caldera, extension directions derived from fault striae P and T axes, and three-dimensional temperature and alteration mineral models are consistent with slip across arcuate ring faults related to magma chamber deflation during flank eruptions and/or a pyroclastic eruption at about 180 ka. These results are not consistent with a rift or pull-apart basin. Limited subsidence can be attributed to the relatively small volume of ash-flow tuff released by the only known major pyroclastic eruption and is inconsistent with the observed topographic relief. The additional relief can be explained by constructional volcanism. Striae from unoriented and oriented core, augmented by striae measurements in outcrop suggest that Walker Lane dextral shear, which can be reasonably projected from the southeast, has probably propagated into the Medicine Lake area. Most volcanic vents across Medicine Lake Volcano strike north-south, suggesting they are controlled by crustal weakness related to Basin and Range extension. Interaction of dextral shear, Basin and Range extension, and the zone of crustal weakness expressed as the Mount Shasta-Medicine Lake volcanic highland controlled the location and initiation of Medicine Lake Volcano at about 500 ka.

  15. Tectonic versus volcanic origin of the summit depression at Medicine Lake Volcano, California

    SciTech Connect (OSTI)

    Mark Leon Gwynn

    2010-05-01

    Medicine Lake Volcano is a Quaternary shield volcano located in a tectonically complex and active zone at the transition between the Basin and Range Province and the Cascade Range of the Pacific Province. The volcano is topped by a 7x12 km elliptical depression surrounded by a discontinuous constructional ring of basaltic to rhyolitic lava flows. This thesis explores the possibility that the depression may have formed due to regional extension (rift basin) or dextral shear (pull-apart basin) rather than through caldera collapse and examines the relationship between regional tectonics and localized volcanism. Existing data consisting of temperature and magnetotelluric surveys, alteration mineral studies, and core logging were compiled and supplemented with additional core logging, field observations, and fault striae studies in paleomagnetically oriented core samples. These results were then synthesized with regional fault data from existing maps and databases. Faulting patterns near the caldera, extension directions derived from fault striae P and T axes, and three-dimensional temperature and alteration mineral models are consistent with slip across arcuate ring faults related to magma chamber deflation during flank eruptions and/or a pyroclastic eruption at about 180 ka. These results are not consistent with a rift or pull-apart basin. Limited subsidence can be attributed to the relatively small volume of ash-flow tuff released by the only known major pyroclastic eruption and is inconsistent with the observed topographic relief. The additional relief can be explained by constructional volcanism. Striae from unoriented and oriented core, augmented by striae measurements in outcrop suggest that Walker Lane dextral shear, which can be reasonably projected from the southeast, has probably propagated into the Medicine Lake area. Most volcanic vents across Medicine Lake Volcano strike north-south, suggesting they are controlled by crustal weakness related to Basin and Range extension. Interaction of dextral shear, Basin and Range extension, and the zone of crustal weakness expressed as the Mount Shasta-Medicine Lake volcanic highland controlled the location and initiation of Medicine Lake Volcano at about 500 ka.

  16. A New Route to Nano Self-Assembly

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    potential for breakthroughs that reverberate through nearly every sector of the economy (medicine, computing, energy, homeland security) is so great that it has already...

  17. Fermilab | Science | Particle Physics | Benefits of Particle...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Workforce Development In this Section: thumb Medicine thumb Homeland Security thumb ... communications, biophysics and finance-wherever the workforce requires highly ...

  18. March 2015 Most Viewed Documents for Biology And Medicine | OSTI, US Dept

    Office of Scientific and Technical Information (OSTI)

    of Energy, Office of Scientific and Technical Information 5 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. [Brookhaven National Lab., Upton, NY (United States)]|[State Univ. of New York at Stony Brook, Stony Brook, NY (United States). Dept. of Psychiatry]; Fowler, J.S.; Logan, J.; Wang, G.J. [Brookhaven National Lab., Upton, NY (United States)] (1995) 134 Drug Retention Times Center for Human Reliability Studies (2007) 114

  19. Investigation of therapeutic potentials of some selected medicinal plants using neutron activation analysis

    SciTech Connect (OSTI)

    Abubakar, Sani; Isa, Nasiru Fage; Usman, Ahmed Rufai; Khandaker, Mayeen Uddin; Abubakar, Nuraddeen

    2015-04-24

    Series of attempts were made to investigate concentrations of trace elements and their therapeutic properties in various medicinal plants. In this study, samples of some commonly used plants were collected from Bauchi State, Nigeria. They includes leaves of azadirachta indica (neem), Moringa Oleifera (moringa), jatropha curcas (purgin Nut), guiera senegalensis (custard apple) and anogeissus leiocarpus (African birch). These samples were analyzed for their trace elements contents with both short and long irradiation protocols of Instrumental Neutron Activation Analysis (INAA) at Nigerian Research Reactor-1 (NIRR-1) of Ahmadu Bello University, Zaria, Nigeria. The level of trace elements found varies from one sample to another, with some reported at hundreds of mg/Kg dry weight. The results have been compared with the available literature data. The presence of these trace elements indicates promising potentials of these plants for relief of certain ailments.

  20. Neurotoxicological effects of cinnabar (a Chinese mineral medicine, HgS) in mice

    SciTech Connect (OSTI)

    Huang, C.-F.; Liu, S.-H.; Lin-Shiau, S.-Y.

    2007-10-15

    Cinnabar, a naturally occurring mercuric sulfide (HgS), has long been used in combination with traditional Chinese medicine as a sedative for more than 2000 years. Up to date, its pharmacological and toxicological effects are still unclear, especially in clinical low-dose and long-term use. In this study, we attempted to elucidate the effects of cinnabar on the time course of changes in locomotor activities, pentobarbital-induced sleeping time, motor equilibrium performance and neurobiochemical activities in mice during 3- to 11-week administration at a clinical dose of 10 mg/kg/day. The results showed that cinnabar was significantly absorbed by gastrointestinal (G-I) tract and transported to brain tissues. The spontaneous locomotor activities of male mice but not female mice were preferentially suppressed. Moreover, frequencies of jump and stereotype-1 episodes were progressively decreased after 3-week oral administration in male and female mice. Pentobarbital-induced sleeping time was prolonged and the retention time on a rotating rod (60 rpm) was reduced after treatment with cinnabar for 6 weeks and then progressively to a greater extent until the 11-week experiment. In addition, the biochemical changes in blood and brain tissues were studied; the inhibition of Na{sup +}/K{sup +}-ATPase activities, increased production of lipid peroxidation (LPO) and nitric oxide (NO) were found with a greater extent in male mice than those in female mice, which were apparently correlated with their differences in the neurological responses observed. In conclusion, these findings, for the first time, provide evidence of the pharmacological and toxicological basis for understanding the sedative and neurotoxic effects of cinnabar used as a Chinese mineral medicine for more than 2000 years.

  1. Nuclear Medicine Program progress report for quarter ending June 30, 1993

    SciTech Connect (OSTI)

    Knapp, F.F. Jr.; Ambrose, K.R.; Beets, A.L.; Callahan, A.P.; Hsieh, B.T.; McPherson, D.W.; Mirzadeh, S.; Lambert, C.R.

    1993-07-01

    The ``IQNP`` agent is an antagonist for the cholinergic-muscarinic receptor. Since the IQNP molecule has two asymmetric centers and either cis or trans isomerism of the vinyl iodide, there are eight possible isomeric combinations. In this report, the systematic synthesis, purification and animal testing of several isomers of radioiodinated ``IQNP`` are reported. A dramatic and unexpected relation between the absolute configuration at the two asymmetric centers and the stereochemistry of the vinyl iodide on receptor specificity was observed. The E-(R)(R) isomer shows specific and significant localization (per cent dose/gram at 6 hours) in receptor-rich cerebral structures (i.e. Cortex = 1.38 + 0.31; Striatum = 1.22 + 0.20) and low uptake in tissues rich in the M{sub 2} subtype (Heart = 0.10; Cerebellum = 0.04). In contrast, the E-(R)(S) isomer shows very low receptor-specific uptake (Cortex = 0.04; Striatum = 0.02), demonstrating the importance of absolute configuration at the acetate center. An unexpected and important observation is that the stereochemistry of the vinyl iodine appears to affect receptor subtype specificity, since the Z-(R,S)(R) isomer shows much higher uptake in the heart (0.56 + 0.12) and cerebellum (0.17 + 0.04). Studies are now in progress to confirm these exciting results in vitro. Progress has also continued during this period with several collaborative programs. The first large-scale clinical tungsten-188/rhenium-188 generator prototype (500 mCi) was fabricated and supplied to the Center for Molecular Medicine and Immunology (CMMI), in Newark, New Jersey, for Phase I clinical trials of rhenium-188-labeled anti CEA antibodies for patient treatment. Collaborative studies are also continuing in conjunction with the Nuclear Medicine Department at the University of Massachusetts where a generator is in use to compare the biological properties of {open_quotes}direct{close_quotes} and {open_quotes}indirect{close_quotes} labeled antibodies.

  2. LHCNet: Wide Area Networking and Collaborative Systems for HEP

    SciTech Connect (OSTI)

    Newman, H.B,

    2007-08-20

    This proposal presents the status and progress in 2006-7, and the technical and financial plans for 2008-2010 for the US LHCNet transatlantic network supporting U.S. participation in the LHC physics program. US LHCNet provides transatlantic connections of the Tier1 computing facilities at Fermilab and Brookhaven with the Tier0 and Tier1 facilities at CERN as well as Tier1s elsewhere in Europe and Asia. Together with ESnet, Internet2, the GEANT pan-European network, and NSF’s UltraLight project, US LHCNet also supports connections between the Tier2 centers (where most of the analysis of the data will take place, starting this year) and the Tier1s as needed.See report

  3. High-Performance Secure Database Access Technologies for HEP Grids

    SciTech Connect (OSTI)

    Matthew Vranicar; John Weicher

    2006-04-17

    The Large Hadron Collider (LHC) at the CERN Laboratory will become the largest scientific instrument in the world when it starts operations in 2007. Large Scale Analysis Computer Systems (computational grids) are required to extract rare signals of new physics from petabytes of LHC detector data. In addition to file-based event data, LHC data processing applications require access to large amounts of data in relational databases: detector conditions, calibrations, etc. U.S. high energy physicists demand efficient performance of grid computing applications in LHC physics research where world-wide remote participation is vital to their success. To empower physicists with data-intensive analysis capabilities a whole hyperinfrastructure of distributed databases cross-cuts a multi-tier hierarchy of computational grids. The crosscutting allows separation of concerns across both the global environment of a federation of computational grids and the local environment of a physicist’s computer used for analysis. Very few efforts are on-going in the area of database and grid integration research. Most of these are outside of the U.S. and rely on traditional approaches to secure database access via an extraneous security layer separate from the database system core, preventing efficient data transfers. Our findings are shared by the Database Access and Integration Services Working Group of the Global Grid Forum, who states that "Research and development activities relating to the Grid have generally focused on applications where data is stored in files. However, in many scientific and commercial domains, database management systems have a central role in data storage, access, organization, authorization, etc, for numerous applications.” There is a clear opportunity for a technological breakthrough, requiring innovative steps to provide high-performance secure database access technologies for grid computing. We believe that an innovative database architecture where the secure authorization is pushed into the database engine will eliminate inefficient data transfer bottlenecks. Furthermore, traditionally separated database and security layers provide an extra vulnerability, leaving a weak clear-text password authorization as the only protection on the database core systems. Due to the legacy limitations of the systems’ security models, the allowed passwords often can not even comply with the DOE password guideline requirements. We see an opportunity for the tight integration of the secure authorization layer with the database server engine resulting in both improved performance and improved security. Phase I has focused on the development of a proof-of-concept prototype using Argonne National Laboratory’s (ANL) Argonne Tandem-Linac Accelerator System (ATLAS) project as a test scenario. By developing a grid-security enabled version of the ATLAS project’s current relation database solution, MySQL, PIOCON Technologies aims to offer a more efficient solution to secure database access.

  4. Langston University - High Energy Physics (LU-HEP)

    SciTech Connect (OSTI)

    Snow, Dr., Joel [Langston Univ., OK (United States)

    2012-08-13

    This final report is presented by Langston University (LU) for the project entitled "Langston University High Energy Physics" (LUHEP) under the direction of principal investigator (PI) and project director Professor Joel Snow. The project encompassed high energy physics research performed at hadron colliders. The PI is a collaborator on the DZero experiment at Fermi National Accelerator Laboratory in Batavia, IL, USA and the ATLAS experiment at CERN in Geneva, Switzerland and was during the entire project period from April 1, 1999 until May 14, 2012. Both experiments seek to understand the fundamental constituents of the physical universe and the forces that govern their interactions. In 1999 as member of the Online Systems group for Run 2 the PI developed a cross-platform Python-based, Graphical User Interface (GUI) application for monitoring and control of EPICS based devices for control room use. This served as a model for other developers to enhance and build on for further monitoring and control tasks written in Python. Subsequently the PI created and developed a cross-platform C++ GUI utilizing a networked client-server paradigm and based on ROOT, the object oriented analysis framework from CERN. The GUI served as a user interface to the Examine tasks running in the D\\O\\ control room which monitored the status and integrity of data taking for Run 2. The PI developed the histogram server/control interface to the GUI client for the EXAMINE processes. The histogram server was built from the ROOT framework and was integrated into the D\\O\\ framework used for online monitoring programs and offline analysis. The PI developed the first implementation of displaying histograms dynamically generated by ROOT in a Web Browser. The PI's work resulted in several talks and papers at international conferences and workshops. The PI established computing software infrastructure at LU and U. Oklahoma (OU) to do analysis of DZero production data and produce simulation data for the experiment. Eventually this included the FNAL SAM data grid system, the SAMGrid (SG) infrastructure, and the Open Science Grid software stacks for computing and storage elements. At the end of 2003 Snow took on the role of global Monte Carlo production coordinator for the D experiment. A role which continues til this day. In January of 2004 Snow started working with the SAMGrid development team to help debug, deploy, and integrate SAMGrid with D Monte Carlo production. Snow installed and configured SG execution and client sites at LUHEP and OUHEP, and a SG scheduler site at LUHEP. The PI developed a python based GUI (DAJ) that acts as a front end for job submission to SAMGrid. The GUI interfaces to the DZero Mone Carlo (MC) request system that uses SAM to manage MC requests by the physics analysis groups. DAJ significantly simplified SG job submission and was deployed in DZero in an effort to increase the user base of SG. The following year was the advent of SAMGrid job submission to the Open Science Grid (OSG) and LHC Computing Grid (LCG) through a forwarding mechanism. The PI oversaw the integration of these grids into the existing production infrastructure. The PI developed an automatic MC (Automc) request processing system capable of operating without user intervention (other than getting grid credentials), and able to submit to any number of sites on various grids. The system manages production at all but 2 sites. The system was deployed at Fermilab and remains operating there today. The PI's work in distributed computing resulted in several talks at international conferences. UTA, OU, and LU were chosen as the collaborating institutions that form the Southwest Tier 2 Center (SWT2) for ATLAS. During the project period the PI contributed to the online and offline software infrastructure through his work with the Run 2 online group, and played a major role in Monte Carlo production for DZero. During the part of the project period in which the PI served as MC production coordinator MC production increased very significantly. In the first year of the PI'

  5. Future directions of accelerator-based NP and HEP facilities

    SciTech Connect (OSTI)

    Roser, T.

    2011-07-24

    Progress in particle and nuclear physics has been closely connected to the progress in accelerator technologies - a connection that is highly beneficial to both fields. This paper presents a review of the present and future facilities and accelerator technologies that will push the frontiers of high-energy particle interactions and high intensity secondary particle beams.

  6. 27264_ESNet_HEP_NP_Cover_final3_102113

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... the Vanderbilt Tier-2, Feb. 13, 2013. 75 which was ... first-pass analysis. (a) (b) Figure 53. WAN traffic comparison for a two-week period; (a) 2013 May 19 and (b) 2011 May 22 ...

  7. A review of event processing frameworks used in HEP

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Sexton-Kennedy, E.

    2015-12-23

    Today there are many different experimental event processing frameworks in use by running or about to be running experiments. This talk will discuss the different components of these frameworks. In the past there have been attempts at shared framework projects for example the collaborations on the BaBar framework (between BaBar, CDF, and CLEO), on the Gaudi framework (between LHCb and ATLAS), on AliROOT/FairROOT (between Alice and GSI/Fair), and in some ways on art (Fermilab based experiments) and CMS’ framework. However, for reasons that will be discussed, these collaborations did not result in common frameworks shared among the intended experiments. Thoughmore » importantly, two of the resulting projects have succeeded in providing frameworks that are shared among many customer experiments: Fermilab's art framework and GSI/Fair's FairROOT. Interestingly, several projects are considering remerging their frameworks after many years apart. I'll report on an investigation and analysis of these realities. In addition, with the advent of the need for multi-threaded frameworks and the scarce available manpower, it is important to collaborate in the future, however it is also important to understand why previous attempts at multi-experiment frameworks either worked or didn't work.« less

  8. 2015-06-LATBauerdick-DOE-ASCR-HEP.key

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... archival systems with tape library backends * Workflows and data ... Requirements Reviews -High Energy Physics 061015 Atlas Sustained Usage (World) 11 U.S. A TLAS O ...

  9. Future HEP Accelerators: The US Perspective (Conference) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Visit OSTI to utilize additional information resources in energy science and technology. A ... Energy Frontier colliders that enable direct discoveries and studies of high mass ...

  10. Final Report: High Energy Physics Program (HEP), Physics Department...

    Office of Scientific and Technical Information (OSTI)

    McDonald, Pe- ter Meyers, James Olsen, Pierre Pirou19;e, Eric Prebys, A.J. Stewart Smith, Frank Shoemaker (deceased), Paul Steinhardt, David Stickland, Christopher Tully, and...

  11. Microsoft Word - HEP-White-Papers-Public.docx

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of expertise or to prepare an individual case s tudy. P lease s ee b elow f or y our n ame i n t he d etailed o utline t o i dentify w here we w ould l ike y ou to focus. In the...

  12. Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine.

    SciTech Connect (OSTI)

    Martino, Mikael M.; Brkic, Sime; Bovo, Emmanuela; Burger, Maximilian; Schaefer, Dirk J.; Wolff, Thomas; Gurke, Lorenz; Briquez, Priscilla S.; Larsson, Hans M.; Gianni-Barrera, Roberto; Hubbell, Jeffrey A.; Banfi, Andrea

    2015-04-01

    Blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular, the spatial localization of angiogenic signals in the extracellular matrix (ECM) is crucial to ensure the proper assembly and maturation of new vascular structures. Here, we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors.

  13. Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine

    SciTech Connect (OSTI)

    Martino, Mikael M.; Brkic, Sime; Bovo, Emmanuela; Burger, Maximilian; Schaefer, Dirk J.; Wolff, Thomas; Gurke, Lorenz; Briquez, Priscilla S.; Larsson, Hans M.; Gianni-Barrera, Roberto; Hubbell, Jeffrey A.; Banfi, Andrea

    2015-04-01

    In this study, blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular, the spatial localization of angiogenic signals in the extracellular matrix (ECM) is crucial to ensure the proper assembly and maturation of new vascular structures. Here, we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors.

  14. TOXNET and Beyond-Using the National Library of Medicine's Environmental Health and Toxicology Portal

    SciTech Connect (OSTI)

    Templin-Branner, Wilma

    2011-01-01

    The purpose of this training is to familiarize participants with reliable online environmental health and toxicology information, from the National Library of Medicine and other reliable sources. Skills and knowledge acquired in this training class will enable participants to access, utilize, and refer others to environmental health and toxicology information. After completing this course, participants will be able to: (1) Identify quality, accurate, and authoritative online resources pertaining to environmental health, toxicology, and related medical information; (2) Demonstrate the ability to perform strategic search techniques to find relevant online information; and (3) Apply the skills and knowledge obtained in this class to their organization's health information needs. NLMs TOXNET (Toxicology Data Network) is a free, Web-based system of databases on toxicology, environmental health, hazardous chemicals, toxic releases, chemical nomenclatures, and specialty areas such as occupational health and consumer products. Types of information in the TOXNET databases include: (1) Specific chemicals, mixtures, and products; (2) Unknown chemicals; and (3) Special toxic effects of chemicals in humans and/or animals.

  15. Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Martino, Mikael M.; Brkic, Sime; Bovo, Emmanuela; Burger, Maximilian; Schaefer, Dirk J.; Wolff, Thomas; Gurke, Lorenz; Briquez, Priscilla S.; Larsson, Hans M.; Gianni-Barrera, Roberto; et al

    2015-04-01

    In this study, blood vessel growth plays a key role in regenerative medicine, both to restore blood supply to ischemic tissues and to ensure rapid vascularization of clinical-size tissue-engineered grafts. For example, vascular endothelial growth factor (VEGF) is the master regulator of physiological blood vessel growth and is one of the main molecular targets of therapeutic angiogenesis approaches. However, angiogenesis is a complex process and there is a need to develop rational therapeutic strategies based on a firm understanding of basic vascular biology principles, as evidenced by the disappointing results of initial clinical trials of angiogenic factor delivery. In particular,more » the spatial localization of angiogenic signals in the extracellular matrix (ECM) is crucial to ensure the proper assembly and maturation of new vascular structures. Here, we discuss the therapeutic implications of matrix interactions of angiogenic factors, with a special emphasis on VEGF, as well as provide an overview of current approaches, based on protein and biomaterial engineering that mimic the regulatory functions of ECM to optimize the signaling microenvironment of vascular growth factors.« less

  16. EIS-0432: Department of Energy Loan Guarantee for Medicine Bow Gasification and Liquefaction Coal-to-Liquids, Carbon County, Wyoming

    Broader source: Energy.gov [DOE]

    DOE is assessing the potential environmental impacts for its proposed action of issuing a Federal loan guarantee to Medicine Bow Fuel & Power LLC (MBFP), a wholly-owned subsidiary of DKRW Advanced Fuels LLC. MBFP submitted an application to DOE under the Federal loan guarantee program pursuant to the Energy Policy Act of 2005 to support the construction and startup of the MBFP coal-to-liquids facility, a coal mine and associated coal handling facilities. This project is inactive.

  17. Patient-Physician Communication About Complementary and Alternative Medicine in a Radiation Oncology Setting

    SciTech Connect (OSTI)

    Ge Jin; Fishman, Jessica; Annenberg School for Communication at University of Pennsylvania, University of Pennsylvania Health System, Philadelphia, Pennsylvania ; Vapiwala, Neha; Department of Radiation Oncology, University of Pennsylvania Health System, Philadelphia, Pennsylvania ; Li, Susan Q.; Desai, Krupali; Xie, Sharon X.; Mao, Jun J.

    2013-01-01

    Purpose: Despite the extensive use of complementary and alternative medicine (CAM) among cancer patients, patient-physician communication regarding CAM therapies remains limited. This study quantified the extent of patient-physician communication about CAM and identified factors associated with its discussion in radiation therapy (RT) settings. Methods and Materials: We conducted a cross-sectional survey of 305 RT patients at an urban academic cancer center. Patients with different cancer types were recruited in their last week of RT. Participants self-reported their demographic characteristics, health status, CAM use, patient-physician communication regarding CAM, and rationale for/against discussing CAM therapies with physicians. Multivariate logistic regression was used to identify relationships between demographic/clinical variables and patients' discussion of CAM with radiation oncologists. Results: Among the 305 participants, 133 (43.6%) reported using CAM, and only 37 (12.1%) reported discussing CAM therapies with their radiation oncologists. In multivariate analyses, female patients (adjusted odds ratio [AOR] 0.45, 95% confidence interval [CI] 0.21-0.98) and patients with full-time employment (AOR 0.32, 95% CI 0.12-0.81) were less likely to discuss CAM with their radiation oncologists. CAM users (AOR 4.28, 95% CI 1.93-9.53) were more likely to discuss CAM with their radiation oncologists than were non-CAM users. Conclusions: Despite the common use of CAM among oncology patients, discussions regarding these treatments occur rarely in the RT setting, particularly among female and full-time employed patients. Clinicians and patients should incorporate discussions of CAM to guide its appropriate use and to maximize possible benefit while minimizing potential harm.

  18. Proposed new accelerator design for homeland security x-ray applications

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Clayton, James; Shedlock, Daniel; Langeveld, Willem G.J.; Bharadwaj, Vinod; Nosochkov, Yuri

    2015-01-01

    Two goals for security scanning of cargo and freight are the ability to determine the type of material that is being imaged, and to do so at low radiation dose. One commonly used technique to determine the effective Z of the cargo is dual-energy imaging, i.e. imaging with different x-ray energy spectra. Another technique uses the fact that the transmitted x-ray spectrum itself also depends on the effective Z. Spectroscopy is difficult because the energy of individual x rays needs to be measured in a very high count-rate environment. Typical accelerators for security applications offer large but short bursts ofmore » x-rays, suitable for current-mode integrated imaging. In order to perform x-ray spectroscopy, a new accelerator design is desired that has the following features: 1) increased duty factor in order to spread out the arrival of x-rays at the detector array over time; 2) x-ray intensity modulation from one delivered pulse to the next by adjusting the accelerator electron beam instantaneous current so as to deliver adequate signal without saturating the spectroscopic detector; and 3) the capability to direct the (forward peaked) x-ray intensity towards high-attenuation areas in the cargo (“fan-beam-steering”). Current sources are capable of 0.1% duty factor, although usually they are operated at significantly lower duty factors (~0.04%), but duty factors in the range 0.4-1.0% are desired. The higher duty factor can be accomplished, e.g., by moving from 300 pulses per second (pps) to 1000 pps and/or increasing the pulse duration from a typical 4 μs to 10 μs. This paper describes initial R&D to examine cost effective modifications that could be performed on a typical accelerator for these purposes, as well as R&D for fan-beam steering.« less

  19. Proposed new accelerator design for homeland security x-ray applicatio...

    Office of Scientific and Technical Information (OSTI)

    in a very high count-rate environment. Typical accelerators for security applications offer large but short bursts of x-rays, suitable for current-mode integrated imaging. In...

  20. Incorporating Sustainability into Lease and Build Agreements; U.S. Department of Homeland Security (DHS)

    SciTech Connect (OSTI)

    2015-05-26

    This fact sheet discusses the benefits of incorporating sustainability into lease and build agreements.

  1. FEMA Fiscal Year (FY) 2015 Tribal Homeland Security Grant Program (THSGP) Notice of Funding Opportunity (NOFO)

    Broader source: Energy.gov [DOE]

    The FY 2015 THSGP supports the building, sustainment and delivery of core capabilities to enable Tribes to strengthen their capacity to prevent, protect against, mitigate, respond to, and recover from potential terrorist attacks and other hazards.

  2. Proposed New Accelerator Design for Homeland Security X-Ray Applicatio...

    Office of Scientific and Technical Information (OSTI)

    A smaller radiation exclusion zone may be accomplished through better beam collimation and an integrated, x-ray-sourcedetector-array assembly to allow feedback and control of an ...

  3. ADMINISTRATIVE CHANGE TO DOE O 484.1, REIMBURSABLE WORK FOR THE DEPARTMENT OF HOMELAND

    Office of Environmental Management (EM)

    ACQUISITION PLANNING ACQUISITION PLANNING More Documents & Publications 7pt1AcquisitionPlanning.pdf Update of Acquisition Guide Chapter 7.1, Acquisition Planning Source Selection

    ADA Requirements for Workplace Charging Installation ADA Requirements for Workplace Charging Installation The Americans with Disabilities Act (ADA) is a federal civil rights law that prohibits discrimination in public places against individuals with disabilities. This Guidance provides best practices, special

  4. Proposed new accelerator design for homeland security x-ray applications

    SciTech Connect (OSTI)

    Clayton, James; Shedlock, Daniel; Langeveld, Willem G.J.; Bharadwaj, Vinod; Nosochkov, Yuri

    2015-01-01

    Two goals for security scanning of cargo and freight are the ability to determine the type of material that is being imaged, and to do so at low radiation dose. One commonly used technique to determine the effective Z of the cargo is dual-energy imaging, i.e. imaging with different x-ray energy spectra. Another technique uses the fact that the transmitted x-ray spectrum itself also depends on the effective Z. Spectroscopy is difficult because the energy of individual x rays needs to be measured in a very high count-rate environment. Typical accelerators for security applications offer large but short bursts of x-rays, suitable for current-mode integrated imaging. In order to perform x-ray spectroscopy, a new accelerator design is desired that has the following features: 1) increased duty factor in order to spread out the arrival of x-rays at the detector array over time; 2) x-ray intensity modulation from one delivered pulse to the next by adjusting the accelerator electron beam instantaneous current so as to deliver adequate signal without saturating the spectroscopic detector; and 3) the capability to direct the (forward peaked) x-ray intensity towards high-attenuation areas in the cargo (fan-beam-steering). Current sources are capable of 0.1% duty factor, although usually they are operated at significantly lower duty factors (~0.04%), but duty factors in the range 0.4-1.0% are desired. The higher duty factor can be accomplished, e.g., by moving from 300 pulses per second (pps) to 1000 pps and/or increasing the pulse duration from a typical 4 ?s to 10 ?s. This paper describes initial R&D to examine cost effective modifications that could be performed on a typical accelerator for these purposes, as well as R&D for fan-beam steering.

  5. Proposed New Accelerator Design for Homeland Security X-Ray Applicatio...

    Office of Scientific and Technical Information (OSTI)

    Authors: Clayton, James 1 ; Shedlock, Daniel 1 ; Langeveld, Willem G.J. 2 ; Bharadwaj, Vinod 3 ; Nosochkov, Yuri 3 + Show Author Affiliations Varian Medical Systems, ...

  6. DOE O 484.1 Admin Chg 1, Reimbursable Work for the Department of Homeland

    Office of Environmental Management (EM)

    O 420.1B/1C Crosswalk Matrix DOE O 420.1B/1C Crosswalk Matrix March 12, 2013 Crosswalk of requirements of DOE Order 420.1B to 420.1C PDF icon DOE O 420.1B/1C Crosswalk Matrix More Documents & Publications Review of Natural Phenomena Hazards (NPH) Requirements Currently Applied to the Thomas Jefferson National Accelerator Facility (TJNAF) Frequently Asked Questions Regarding DOE Order 420.1C, Facility Safety DOE Order 420.1C Briefing

    O 451.1B Chg 3 1-19-12 ADMINISTRATIVE CHANGE TO DOE O

  7. Before the Subcommittee on Financial and Contracting Oversight- Committee on Homeland Security and Governmental Affairs

    Broader source: Energy.gov [DOE]

    Subject: Overview of DOE Office of Environmental Management acquisitions and contract project management reforms By: J.E. "Jack" Surash, Deputy Assistant Secretary for Acquisition and Project Management

  8. Implementation of test for quality assurance in nuclear medicine gamma camera

    SciTech Connect (OSTI)

    Montoya Moreno, A.; Rodriguez Laguna, A.; Trujillo Zamudio, Flavio E

    2012-10-23

    In nuclear medicine (NM) over 90% of procedures are performed for diagnostic purposes. To ensure adequate diagnostic quality of images and the optimization of the doses received by patients originated from the radioactive material is essential for regular monitoring and equipment performance through a quality assurance program (QAP). The QAP consists of 15 proposed performance tomographic and not tomographic gamma camera (GC) tests, and is based on recommendations of international organizations. We describe some results of the performance parameters of QAP applied to a GC model e.cam Siemens, of the Department of NM of the National Cancer Institute of Mexico (INCan). The results were: (1) The average intrinsic spatial resolution (R{sub in}) was 4.67 {+-} 0.25 mm at the limit of acceptance criterion of 4.4 mm. (2) The sensitivity extrinsic (S{sub ext}), with maximum variations of 1.8% (less than 2% which is the criterion of acceptance). (3) Rotational Uniformity (U{sub rot}), with values of integral uniformity (IU) in the useful field of view detector (UFOV), with maximum percentage change of 0.97% and monthly variations equal angles, ranging from 0.13 to 0.99% less than 1%. (4) The displacement of the center of rotation (DCOR), indicated a maximum deviation of 0.155 {+-} 0.039 mm less than 4.795 mm, an absolute deviation of less than 0.5 where pixel 0.085 pixel is suggested, the criteria are assigned to low-energy collimator high resolution. (5) In tomographic uniformity (U{sub tomo}), UI values (%) and percentage noise level (rms%) were 7.54 {+-} 1.53 and 4.18 {+-} 1.69 which are consistent with the limits of acceptance of 7.0-12.0% and 3.0-6.0% respectively. The smallest cold sphere has a diameter of 11.4 mm. The implementation of a QAP allows for high quality diagnostic images, optimization of the doses given to patients, a reduction of exposure to occupationally exposed workers (POE, by its Spanish acronym), and generally improves the productivity of the service. This proposal can be used to develop a similar QAP in other facilities and may serve as a precedent for the proposed regulations for quality assurance (QA) teams in MN.

  9. Radiotherapy and Nuclear Medicine Project for an Integral Oncology Center at the Oaxaca High Specialization Regional Hospital

    SciTech Connect (OSTI)

    De Jesus, M.; Trujillo-Zamudio, F. E.

    2010-12-07

    A building project of Radiotherapy and Nuclear Medicine services (diagnostic and therapy), within an Integral Oncology Center (IOC), requires interdisciplinary participation of architects, biomedical engineers, radiation oncologists and medical physicists. This report focus on the medical physicist role in designing, building and commissioning stages, for the final clinical use of an IOC at the Oaxaca High Specialization Regional Hospital (HRAEO). As a first step, during design stage, the medical physicist participates in discussions about radiation safety and regulatory requirements for the National Regulatory Agency (called CNSNS in Mexico). Medical physicists propose solutions to clinical needs and take decisions about installing medical equipment, in order to fulfill technical and medical requirements. As a second step, during the construction stage, medical physicists keep an eye on building materials and structural specifications. Meanwhile, regulatory documentation must be sent to CNSNS. This documentation compiles information about medical equipment, radioactivity facility, radiation workers and nuclear material data, in order to obtain the license for the linear accelerator, brachytherapy and nuclear medicine facilities. As a final step, after equipment installation, the commissioning stage takes place. As the conclusion, we show that medical physicists are essentials in order to fulfill with Mexican regulatory requirements in medical facilities.

  10. A Prospective, Multicenter Study of Complementary/Alternative Medicine (CAM) Utilization During Definitive Radiation for Breast Cancer

    SciTech Connect (OSTI)

    Moran, Meena S.; Ma Shuangge; Jagsi, Reshma; Yang, Tzu-I Jonathan; Higgins, Susan A.; Department of Radiation Therapy, Shoreline Medical Center, Guilford, Connecticut ; Weidhaas, Joanne B.; Wilson, Lynn D.; Department of Radiation Therapy, Lawrence and Memorial Hospital, New London, Connecticut ; Lloyd, Shane; Peschel, Richard; Department of Radiation Therapy, Lawrence and Memorial Hospital, New London, Connecticut ; Gaudreau, Bryant; Rockwell, Sara

    2013-01-01

    Purpose: Although complementary and alternative medicine (CAM) utilization in breast cancer patients is reported to be high, there are few data on CAM practices in breast patients specifically during radiation. This prospective, multi-institutional study was conducted to define CAM utilization in breast cancer during definitive radiation. Materials/Methods: A validated CAM instrument with a self-skin assessment was administered to 360 Stage 0-III breast cancer patients from 5 centers during the last week of radiation. All data were analyzed to detect significant differences between users/nonusers. Results: CAM usage was reported in 54% of the study cohort (n=194/360). Of CAM users, 71% reported activity-based CAM (eg, Reiki, meditation), 26% topical CAM, and 45% oral CAM. Only 16% received advice/counseling from naturopathic/homeopathic/medical professionals before initiating CAM. CAM use significantly correlated with higher education level (P<.001), inversely correlated with concomitant hormone/radiation therapy use (P=.010), with a trend toward greater use in younger patients (P=.066). On multivariate analysis, level of education (OR: 6.821, 95% CI: 2.307-20.168, P<.001) and hormones/radiation therapy (OR: 0.573, 95% CI: 0.347-0.949, P=.031) independently predicted for CAM use. Significantly lower skin toxicity scores were reported in CAM users vs nonusers, respectively (mild: 34% vs 25%, severe: 17% vs 29%, P=.017). Conclusion: This is the first prospective study to assess CAM practices in breast patients during radiation, with definition of these practices as the first step for future investigation of CAM/radiation interactions. These results should alert radiation oncologists that a large percentage of breast cancer patients use CAM during radiation without disclosure or consideration for potential interactions, and should encourage increased awareness, communication, and documentation of CAM practices in patients undergoing radiation treatment for breast cancer.

  11. Development of radiohalogenated muscarinic ligands for the in vivo imaging of m-AChR by nuclear medicine techniques

    SciTech Connect (OSTI)

    McPherson, D.W.; Luo, H.; Knapp, F.F. Jr.

    1994-06-01

    Alterations in the density of acetylcholinergic muscarinic receptors (m-AChR) have been observed in various dementias. This has spurred interest in the development of radiohalogenated ligands which can be used for the non-invasive in vivo detection of m-AChR by nuclear medicine techniques. We have developed a new ligand 1-azabicyclo[2.2.2]oct-3-yl ({alpha}-hydroxy-{alpha}-(1-iodo-1-propen-3-yl)-{alpha}-phenylacetate (IQNP,12) which demonstrates high affinity for the muscarinic receptor. When labeled with radioiodine it has been shown to be selective and specific for m-ACHR. Initial studies on the separation and in vivo evaluation of the various isomers of IQNP have shown that the stereochemistry of the chiral centers and the configuration around the double bond play an important role in m-AChR subtype specificity. In vivo evaluation of these stereoisomers demonstrate that E-(R,R)-IQNP has a high affinity for the M{sub 1} muscarinic subtype while Z-(R,R)-IQNP demonstrate a high affinity for M{sub 1} and M{sub 2} receptor subtypes. These data demonstrate IQNP (12) has potential for use in the non-evasive in vivo detection of m-AChR by single photon emission computed tomography (SPECT). A brominated analogue, ``BrQNP,`` in which the iodine has been replaced by a bromine atom, has also been prepared and was shown to block the in vivo uptake of IQNP in the brain and heart and therefore has potential for positron emission tomographic (PET) studies of m-AChR.

  12. Nanoscale Materials in Medicine

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathol. 36: 43-48. http:www.edinformatics.comnanotechnologynanomedicine.htm Efficient ... Science 9(3-4): 222-235. Bawa, R. 2008. Nanotechnology Law and Business, pp. 135-155.

  13. Nuclear medicine imaging system

    DOE Patents [OSTI]

    Bennett, G.W.; Brill, A.B.; Bizais, Y.J.C.; Rowe, R.W.; Zubal, I.G.

    1983-03-11

    It is an object of this invention to provide a nuclear imaging system having the versatility to do positron annihilation studies, rotating single or opposed camera gamma emission studies, and orthogonal gamma emission studies. It is a further object of this invention to provide an imaging system having the capability for orthogonal dual multipinhole tomography. It is another object of this invention to provide a nuclear imaging system in which all available energy data, as well as patient physiological data, are acquired simultaneously in list mode.

  14. Nanoscale Materials in Medicine

    Broader source: Energy.gov [DOE]

    Presentation for the Sustainable Nanomaterials Workshop by Auburn University Department of Chemical Engineering held on June 26, 2012

  15. Fermilab | Science | Particle Physics | Benefits of Particle Physics |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Medicine Medicine In this Section: thumb Medicine thumb Homeland Security thumb Industry thumb Computing thumb Sciences thumb Workforce Development thumb A Growing List Medicine: magnetic resonance imaging Magnetic resonance imaging Magnetic resonance imaging, a fundamental technology of medical diagnosis, uses superconducting magnet technology that originated as a tool for physicists to accelerate protons to the highest energy in the world. MRI produces high-quality images of the inside of

  16. Before the Senate Homeland Security and Governmental Affairs Subcommittee on Federal Financial Management, Government Information, Federal Services, and International Security

    Broader source: Energy.gov [DOE]

    Subject: Cost-Plus Award Fee By: Edward R. Simpson, Director, Office of Procurement and Assistance Management, Office of Management

  17. Before the Senate Homeland Security and Governmental Affairs Subcommittee on Federal Financial Management, Government Information, Federal Services and International Security

    Broader source: Energy.gov [DOE]

    Subject: Cutting the Federal Government's Energy Bill: An Examination of the Sustainable Federal Government Executive Order 13524 By: Richard Kidd, Program Manager Federal Energy Management Program, Office of Energy Efficiency and Renewable Energy

  18. Directions | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    HEP Budget HEP Committees of Visitors Directions Jobs University Research & National Labs Research Facilities Science ... Directions to HEP Quick Links Office of Science HEP symmetry ...

  19. Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine

    SciTech Connect (OSTI)

    Tomar, Geetanjali B.; Srivastava, Rupesh K.; Gupta, Navita; Barhanpurkar, Amruta P.; Pote, Satish T.; Jhaveri, Hiral M.; Mishra, Gyan C.; Wani, Mohan R.

    2010-03-12

    Mesenchymal stem cells (MSCs) are capable of self-renewal and differentiation into multiple cell lineages. Presently, bone marrow is considered as a prime source of MSCs; however, there are some drawbacks and limitations in use of these MSCs for cell therapy. In this study, we demonstrate that human gingival tissue-derived MSCs have several advantages over bone marrow-derived MSCs. Gingival MSCs are easy to isolate, homogenous and proliferate faster than bone marrow MSCs without any growth factor. Importantly, gingival MSCs display stable morphology and do not loose MSC characteristic at higher passages. In addition, gingival MSCs maintain normal karyotype and telomerase activity in long-term cultures, and are not tumorigenic. Thus, we reveal that human gingiva is a better source of MSCs than bone marrow, and large number of functionally competent clinical grade MSCs can be generated in short duration for cell therapy in regenerative medicine and tissue engineering.

  20. HEP User Facilities | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    particle acceleration are carried out. Accelerator Test Facility (ATF) at Brookhaven National Laboratory The Accelerator Test Facility (ATF) provides users with high power lasers ...

  1. HEP Accelerator R&D Expertise | U.S. DOE Office of Science (SC...

    Office of Science (SC) Website

    As needed, promising concepts are tested at national laboratory test facilities, such as the Advanced Wakefield Accelerator (AWA) at ANL, the Accelerator Test Facility (ATF) at ...

  2. Habitat Evaluation Procedures (HEP) Report; Sandy River Delta, Technical Report 2000-2002.

    SciTech Connect (OSTI)

    Rocklage, Ann; Ratti, John

    2002-02-01

    Land managers are often challenged with the mandate to control exotic and invasive plant species. Reed canarygrass (Phalaris arundinacea) and Himalayan blackberry (Rubus discolor) are 2 such species that are currently threatening natural areas in western United States. Reed canarygrass may be native to the inland northwest (Antieau 2000), but it has invaded many wetland areas as dense, monoculture stands. Spread of this plant species is largely attributed to human disturbances, e.g., draining, farming (Antieau 2000). Reed canarygrass often dominates other emergent vegetation such as cattail (Typha spp.) and bulrush (Scirpus spp.) (Whitson et al. 1996, Apfelbaum and Sams 1987), and the resulting habitat is largely unsuitable for wetland birds. Himalayan blackberry was introduced to the United States as a garden shrub and was planted at wildlife-management areas for food and cover. It easily colonizes disturbed places, such as roadsides, ditches, and flood plains (Hoshovsky 2000). Once established, it forms a thick, impenetrable stand, which excludes native shrub species. Although Himalayan blackberry does provide food and cover for wildlife, particularly during fall and winter, it decreases habitat diversity, and therefore, may decrease wildlife diversity. Furthermore, patterns of avian nest predation may be altered in some exotic-shrub communities (Schmidt and Whelan 1999). For land managers to make sound decisions regarding invasive-plant control, it is useful to obtain information on current plant distributions in relation to targeted wildlife species, and then use models to predict how those species may respond to changes in vegetation. The Habitat Evaluations Program was developed by the U.S. Fish and Wildlife Service to evaluate current and future habitat conditions for fish and wildlife (Stiehl 1994). The program is based on Habitat Suitability Index (HSI) models for specific wildlife species. Each model contains several variables that represent life requisites (e.g., food and nesting cover) for that species. These variables are evaluated with vegetation sampling, and/or through the interpretation of aerial photographs and the like. Variable values are assigned a numerical score. The score may be based on a categorical rating (e.g . , different vegetation types receive different scores based on their importance for that species) or may be the result of a linear relationship (e.g., the score increases with the variable value; Figure 1). Variable scores are then input into a mathematical formula, which results in an HSI score. The HSI score ranges from 0-1, with 0 representing poor-quality habitat and 1 optimal habitat. HSI models assume a positive, linear relationship between wildlife-species density and the HSI score. For example, with an HSI score of 1, we assume that a species will be present at its highest density. Models can be projected into the future by changing variable values and observing the corresponding changes in HSI scores. Most models are relatively simple, but some are complex. These models have come under considerable scrutiny in the last several years, particularly concerning the validity of model assumptions (Van Horne 1983, Laymon and Barrett 1986, Hobbs and Hanley 1990, Kellner et al. 1992). Regardless of criticisms, these models may be used with success when there is an understanding and acceptance of model limitations. Each model should be evaluated as to its applicability in a given situation. Model validation, where results have on-the-ground verification, is highly recommended. Specific objectives of this project were to (1) conduct avian surveys and measure the present vegetation at the Sandy River Delta, (2) input the vegetation data into HSI models for 5 avian species, (3) evaluate the current habitat suitability for these species, and (4) predict species responses to potential changes in vegetation, resulting from the removal of reed canarygrass and/or Himalayan blackberry.

  3. Microsoft Word - OE HEPS cybersecurity hearing May 31 2011_2...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    the modernization of the Nation's electricity transmission and distribution system to maintain ... This public-private investment worth over 9.6 billion was dedicated to a nationwide ...

  4. Habitat Evaluation Procedures (HEP) Report; Tacoma/Trimble Area Management Plan, Technical Report 2001-2003.

    SciTech Connect (OSTI)

    Entz, Ray; Lockwood, Jr., Neil; Holmes, Darren

    2003-10-01

    In 2000 and 2001, the Kalispel Natural Resource Department (KNRD) continued to mitigate the wildlife habitat losses as part of the Albeni Falls Wildlife Mitigation Project. Utilizing Bonneville Power Administration (BPA) funds, the Kalispel Tribe of Indians (Tribe) purchased three projects totaling nearly 1,200 acres. The Tacoma/Trimble Wildlife Management Area is a conglomeration of properties now estimated at 1,700 acres. It is the Tribe's intent to manage these properties in cooperation and collaboration with the Pend Oreille County Public Utility District (PUD) No. 1 and the U.S. Fish and Wildlife Service (USFWS) to benefit wildlife habitats and associated species, populations, and guilds.

  5. Microsoft Word - OE HEPS cybersecurity hearing May 31 2011_2.docx

    Energy Savers [EERE]

    PATRICIA HOFFMAN ASSISTANT SECRETARY OFFICE OF ELECTRICITY DELIVERY AND ENERGY RELIABILITY U.S. DEPARTMENT OF ENERGY BEFORE THE COMMITTEE ON ENERGY AND COMMERCE SUBCOMMITTEE ON ENERGY AND POWER UNITED STATES HOUSE OF REPRESENTATIVES May 31, 2011 2 Chairman Whitfield, Ranking Member Rush and members of the Subcommittee, thank you for this opportunity to discuss the cyber security issues facing the electric industry, as well as potential legislation intended to strengthen protection of the bulk

  6. Final Report: High Energy Physics Program (HEP), Physics Department, Princeton University

    SciTech Connect (OSTI)

    Callan, Curtis G.; Gubser, Steven S.; Marlow, Daniel R.; McDonald, Kirk T.; Meyers, Peter D.; Olsen, James D.; Smith, Arthur J.S.; Steinhardt, Paul J.; Tully, Christopher G.; Stickland, David P.

    2013-04-30

    The activities of the Princeton Elementary particles group funded through Department of Energy Grant# DEFG02-91 ER40671 during the period October 1, 1991 through January 31, 2013 are summarized. These activities include experiments performed at Brookhaven National Lab; the CERN Lab in Geneva, Switzerland; Fermilab; KEK in Tsukuba City, Japan; the Stanford Linear Accelerator Center; as well as extensive experimental and the- oretical studies conducted on the campus of Princeton University. Funded senior personnel include: Curtis Callan, Stephen Gubser, Valerie Halyo, Daniel Marlow, Kirk McDonald, Pe- ter Meyers, James Olsen, Pierre Pirou#19;e, Eric Prebys, A.J. Stewart Smith, Frank Shoemaker (deceased), Paul Steinhardt, David Stickland, Christopher Tully, and Liantao Wang.

  7. arXiv:hep-ph/0111471 v2 4 Dec 2001

    Office of Scientific and Technical Information (OSTI)

    111471 v2 4 Dec 2001 LBNL-49222 Exploring New Physics Through Contact Interactions in Lepton Pair Production at a Linear Collider Gabriella P´ asztor ∗ CERN, CH-1211 Geneva 23, Switzerland Maxim Perelstein † Theory Group, Lawrence Berkeley National Lab, Berkeley, CA 94720, USA (Dated: July 10, 2004) If a contact interaction type correction to a Standard Model process is observed, studying its detailed properties can provide information on the fundamental physics responsible for it. Assuming

  8. arXiv:hep-ph/0212228v2 21 Nov 2003

    Office of Scientific and Technical Information (OSTI)

    1881 Collider Tests of the Little Higgs Model Gustavo Burdman 1 , Maxim Perelstein 1 , and Aaron Pierce 2 1 Theory Group, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 2 Theoretical Physics Group, Stanford Linear Accelerator Center, Stanford, CA 94309. This work was supported in part by the Director, Office of Science, Office of High Energy Physics, of the U.S. Department of Energy under Contract No. DE-AC03-76SF00098. DISCLAIMER This document was prepared as an account of work

  9. US LHCNet: Transatlantic Networking for the LHC and the U.S. HEP Community

    SciTech Connect (OSTI)

    Newman, Harvey B; Barczyk, Artur J

    2013-04-05

    US LHCNet provides the transatlantic connectivity between the Tier1 computing facilities at the Fermilab and Brookhaven National Labs and the Tier0 and Tier1 facilities at CERN, as well as Tier1s elsewhere in Europe and Asia. Together with ESnet, Internet2, and other R&E Networks participating in the LHCONE initiative, US LHCNet also supports transatlantic connections between the Tier2 centers (where most of the data analysis is taking place) and the Tier1s as needed. Given the key roles of the US and European Tier1 centers as well as Tier2 centers on both continents, the largest data flows are across the Atlantic, where US LHCNet has the major role. US LHCNet manages and operates the transatlantic network infrastructure including four Points of Presence (PoPs) and currently six transatlantic OC-192 (10Gbps) leased links. Operating at the optical layer, the network provides a highly resilient fabric for data movement, with a target service availability level in excess of 99.95%. This level of resilience and seamless operation is achieved through careful design including path diversity on both submarine and terrestrial segments, use of carrier-grade equipment with built-in high-availability and redundancy features, deployment of robust failover mechanisms based on SONET protection schemes, as well as the design of facility-diverse paths between the LHC computing sites. The US LHCNet network provides services at Layer 1(optical), Layer 2 (Ethernet) and Layer 3 (IPv4 and IPv6). The flexible design of the network, including modular equipment, a talented and agile team, and flexible circuit lease management, allows US LHCNet to react quickly to changing requirements form the LHC community. Network capacity is provisioned just-in-time to meet the needs, as demonstrated in the past years during the changing LHC start-up plans.

  10. 404 Not Found

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    URL /projects/science_requirements/HEP/HEP-Szalay.pdf was not found on

  11. Engineering Foundation Conference: Advances in optics for biotechnology, medicine, and surgery, Kona Surf Resort and Conference Center, Kailua-Kona, Hawaii, August 1-6, 1999. Final report

    SciTech Connect (OSTI)

    Yodh, Arjun; Sevick-Muraca, Eva; Benaron, David

    2001-09-01

    The intent of the conference was to gather a group of cross-disciplinary investigators from universities, medical schools, national laboratories, industry, and government in order to highlight future applications and technology of the optical sciences in biotechnology, medicine, and surgery. The session chairs brought new participants and speakers to the conference who were not regular attendees of the OSA and SPIE conferences. Attendees included a good number of graduate and post-doctoral students who tended to join the more senior members in organized and spontaneous afternoon activities. A critique of the conference is given which discusses things that worked well and things that could have been better, focusing on costs, funding, and speaker cancellations. Sessions were held on the following topics: Photodynamic therapy: fundamental and clinical studies; Frontiers in spectroscopy; Photon migration; Advances in tissue microscopy, dyes and reporters; Advances in cell microscopy: spectroscopy and micromanipulation; Laser-tissue interactions: therapeutic interventions; and Optics for biotechnology. Along with the program and participant lists, nearly 50 poster presentations are included.

  12. Drill-hole data, drill-site geology, and geochemical data from the study of Precambrian uraniferous conglomerates of the Medicine Bow Mountains and Sierra Madre of southeastern Wyoming

    SciTech Connect (OSTI)

    Karlstrom, K.E.; Houston, R.S.; Schmidt, T.G.; Inlow, D.; Flurkey, A.J.; Kratochvil, A.L.; Coolidge, C.M.; Sever, C.K.; Quimby, W.F.

    1981-02-01

    This volume is presented as a companion to Volume 1: The Geology and Uranium Potential of Precambrian Conglomerates in the Medicine Bow Mountains and Sierra Madre of Southeastern Wyoming; and to Volume 3: Uranium Assessment for Precambrian Pebble Conglomerates in Southeastern Wyoming. Volume 1 summarized the geologic setting and geologic and geochemical characteristics of uranium-bearing conglomerates in Precambrian metasedimentary rocks of southeastern Wyoming. Volume 3 is a geostatistical resource estimate of U and Th in quartz-pebble conglomerates. This volume contains supporting geochemical data, lithologic logs from 48 drill holes in Precambrian rocks of the Medicine Bow Mountains and Sierra Madre, and drill site geologic maps and cross-sections from most of the holes.

  13. WE-A-17A-07: Evaluation of a Grid-Based Boltzmann Solver for Nuclear Medicine Voxel-Based Dose Calculations

    SciTech Connect (OSTI)

    Mikell, J; Kappadath, S; Wareing, T; Mourtada, F

    2014-06-15

    Purpose: Grid-based Boltzmann solvers (GBBS) have been successfully implemented in radiation oncology clinics as dose calculations for e×ternal photon beams and 192Ir sealed-source brachytherapy. We report on the evaluation of a GBBS for nuclear medicine vo×el-based absorbed doses. Methods: Vo×el-S-values were calculated for monoenergetic betas and photons (1, 0.1, 0.01 MeV), 90Y, and 131I for 3 mm vo×el sizes using Monte Carlo (DOS×YZnrc) and GBBS (Attila 8.1-beta5, Transpire). The source distribution was uniform throughout a single vo×el. The material was an infinite 1.04 g/cc soft tissue slab. To e×plore convergence properties of the GBBS 3 tetrahedral meshes, 3 energy group structures, 3 different square Chebyschev-Legendre quadrature set orders (Sn), and 4×2013;7 spherical harmonic e×pansion terms (Pn) were investigated for a total of 168 discretizations per source. The mesh, energy group, and quadrature sets are 8×, 3×, and 16×, respectively, finer than the corresponding coarse discretization. GBBS cross sections were generated with full electronphoton-coupling using the vendors e×tended CEP×S code. For accuracy, percent differences (%Δ) in source vo×el absorbed doses between MC and GBBS are reported for the coarsest and finest discretization. For convergence, ratios of the two finest discretization solutions are reported along each variable. Results: For 1 MeV, 0.1 MeV, 0.01 MeV, Y90, and I-131 beta sources the %Δ in the source vo×el for (coarsest,finest) discretization were (+2.0,−6.4), (−8.0, −7.5), (−13.8, −13.4), (+0.9,−5.5), and (− 10.1,−9.0) respectively. The corresponding %Δ for photons were (+33.7,−7.1), (−9.4, −9.8), (−17.4, −15.2), and (−1.7,−7.7), respectively. For betas, the convergence ratio of mesh, energy, Sn, and Pn ranged from 0.991–1.000. For gammas, the convergence ratio of mesh, Sn, and Pn ranged from 0.998–1.003 while the ratio for energy ranged from 0.964–1.001. Conclusions: GBBS is promising for nuclear medicine vo×el-based dose calculations. Ongoing work includes evaluating GBBS in bone, lung, and realistic clinical PET/SPECT-based activity distributions. Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R01CA138986. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

  14. ‘N-of-1- pathways ’ unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: Towards precision medicine

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Gardeux, Vincent; Achour, Ikbel; Li, Jianrong; Maienschein-Cline, Mark; Li, Haiquan; Pesce, Lorenzo; Parinandi, Gurunadh; Bahroos, Neil; Winn, Robert; Garcia, Joe G. N.; et al

    2014-11-01

    Background: The emergence of precision medicine allowed the incorporation of individual molecular data into patient care. This research entails, DNA sequencing predicts somatic mutations in individual patients. However, these genetic features overlook dynamic epigenetic and phenotypic response to therapy. Meanwhile, accurate personal transcriptome interpretation remains an unmet challenge. Further, N-of-1 (single-subject) efficacy trials are increasingly pursued, but are underpowered for molecular marker discovery. Method: ‘N-of-1-pathways’ is a global framework relying on three principles: (i) the statistical universe is a single patient; (ii) significance is derived from geneset/biomodules powered by paired samples from the same patient; and (iii) similarity between genesets/biomodulesmore » assesses commonality and differences, within-study and cross-studies. Thus, patient gene-level profiles are transformed into deregulated pathways. From RNA-Seq of 55 lung adenocarcinoma patients, N-of-1-pathways predicts the deregulated pathways of each patient. Results: Cross-patient N-of-1-pathways obtains comparable results with conventional genesets enrichment analysis (GSEA) and differentially expressed gene (DEG) enrichment, validated in three external evaluations. Moreover, heatmap and star plots highlight both individual and shared mechanisms ranging from molecular to organ-systems levels (eg, DNA repair, signaling, immune response). Patients were ranked based on the similarity of their deregulated mechanisms to those of an independent gold standard, generating unsupervised clusters of diametric extreme survival phenotypes (p=0.03). Conclusions: The N-of-1-pathways framework provides a robust statistical and relevant biological interpretation of individual disease-free survival that is often overlooked in conventional cross-patient studies. It enables mechanism-level classifiers with smaller cohorts as well as N-of-1 studies.« less

  15. SU-C-9A-02: Structured Noise Index as An Automated Quality Control for Nuclear Medicine: A Two Year Experience

    SciTech Connect (OSTI)

    Nelson, J; Christianson, O; Samei, E

    2014-06-01

    Purpose: Flood-field uniformity evaluation is an essential element in the assessment of nuclear medicine (NM) gamma cameras. It serves as the central element of the quality control (QC) program, acquired and analyzed on a daily basis prior to clinical imaging. Uniformity images are traditionally analyzed using pixel value-based metrics which often fail to capture subtle structure and patterns caused by changes in gamma camera performance requiring additional visual inspection which is subjective and time demanding. The goal of this project was to develop and implement a robust QC metrology for NM that is effective in identifying non-uniformity issues, reporting issues in a timely manner for efficient correction prior to clinical involvement, all incorporated into an automated effortless workflow, and to characterize the program over a two year period. Methods: A new quantitative uniformity analysis metric was developed based on 2D noise power spectrum metrology and confirmed based on expert observer visual analysis. The metric, termed Structured Noise Index (SNI) was then integrated into an automated program to analyze, archive, and report on daily NM QC uniformity images. The effectiveness of the program was evaluated over a period of 2 years. Results: The SNI metric successfully identified visually apparent non-uniformities overlooked by the pixel valuebased analysis methods. Implementation of the program has resulted in nonuniformity identification in about 12% of daily flood images. In addition, due to the vigilance of staff response, the percentage of days exceeding trigger value shows a decline over time. Conclusion: The SNI provides a robust quantification of the NM performance of gamma camera uniformity. It operates seamlessly across a fleet of multiple camera models. The automated process provides effective workflow within the NM spectra between physicist, technologist, and clinical engineer. The reliability of this process has made it the preferred platform for NM uniformity analysis.

  16. ‘N-of-1- pathways ’ unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: Towards precision medicine

    SciTech Connect (OSTI)

    Gardeux, Vincent; Achour, Ikbel; Li, Jianrong; Maienschein-Cline, Mark; Li, Haiquan; Pesce, Lorenzo; Parinandi, Gurunadh; Bahroos, Neil; Winn, Robert; Garcia, Joe G. N.; Foster, Ian; Lussier, Yves A.

    2014-11-01

    Background: The emergence of precision medicine allowed the incorporation of individual molecular data into patient care. This research entails, DNA sequencing predicts somatic mutations in individual patients. However, these genetic features overlook dynamic epigenetic and phenotypic response to therapy. Meanwhile, accurate personal transcriptome interpretation remains an unmet challenge. Further, N-of-1 (single-subject) efficacy trials are increasingly pursued, but are underpowered for molecular marker discovery. Method: ‘N-of-1-pathways’ is a global framework relying on three principles: (i) the statistical universe is a single patient; (ii) significance is derived from geneset/biomodules powered by paired samples from the same patient; and (iii) similarity between genesets/biomodules assesses commonality and differences, within-study and cross-studies. Thus, patient gene-level profiles are transformed into deregulated pathways. From RNA-Seq of 55 lung adenocarcinoma patients, N-of-1-pathways predicts the deregulated pathways of each patient. Results: Cross-patient N-of-1-pathways obtains comparable results with conventional genesets enrichment analysis (GSEA) and differentially expressed gene (DEG) enrichment, validated in three external evaluations. Moreover, heatmap and star plots highlight both individual and shared mechanisms ranging from molecular to organ-systems levels (eg, DNA repair, signaling, immune response). Patients were ranked based on the similarity of their deregulated mechanisms to those of an independent gold standard, generating unsupervised clusters of diametric extreme survival phenotypes (p=0.03). Conclusions: The N-of-1-pathways framework provides a robust statistical and relevant biological interpretation of individual disease-free survival that is often overlooked in conventional cross-patient studies. It enables mechanism-level classifiers with smaller cohorts as well as N-of-1 studies.

  17. Keeping Medicines Cool Without Electircity

    SciTech Connect (OSTI)

    McCormick, Bruce; Coker, Eric

    2014-10-24

    The NanoQ container uses ice and nanoporous insulating material to maintain temperatures required for long-term storage of vaccines in remote areas. Yet how can ice be produced without electricity or batteries?

  18. SC e-journals, Medicine

    Office of Scientific and Technical Information (OSTI)

    ... Trends in Microbiology Veterinary Research Communications Virchows Archiv Virology Virtual Journal of Biomedical Optics Virus Genes X-Ray Spectrometry Zeitschrift fr Kardiologie

  19. Before Senate Committee on Homeland Security and Governmental Affairs Subcommittee on Oversight on Government Management, the Federal Workforce, and the District of Columbia

    Broader source: Energy.gov [DOE]

    Subject: Inspiring Students to Federal Service By: Michael C. Kane, Chief Human Capital Officer, U.S. Department of Energy

  20. Before the Senate Homeland Security and Governmental Affairs Subcommittee on Oversight of Government Management, the Workforce, and the District of Columbia

    Broader source: Energy.gov [DOE]

    Subject: Strengthening the Federal Acquisition Workforce: Government-wide Leadership and Initiatives By: John Bashista, Deputy Director, Office of Procurement and Assistance Management, Office of Management

  1. 2013 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    3 High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits ... Reports HEP Sponsored Workshops and Conferences Contact Information High Energy Physics ...

  2. 2015 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    5 High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits ... Reports HEP Sponsored Workshops and Conferences Contact Information High Energy Physics ...

  3. Agenda

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Director 9:00 HEP Program Office Research Directions James Siegrist HEP Associate Director 9:30 NERSC Role in HEP Research & Emerging Technologies Sudip Dosanjh NERSC...

  4. ORISE: Radiation Emergency Medicine - Continuing Medical Education...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The course begins with a discussion of the fundamentals of radiation physics, radiation detectionmeasurementidentification, prevention of the spread of contamination, how to ...

  5. Institute for Molecular Medicine Research Program

    SciTech Connect (OSTI)

    Phelps, Michael E

    2012-12-14

    The objectives of the project are the development of new Positron Emission Tomography (PET) imaging instrumentation, chemistry technology platforms and new molecular imaging probes to examine the transformations from normal cellular and biological processes to those of disease in pre-clinical animal models. These technology platforms and imaging probes provide the means to: 1. Study the biology of disease using pre-clinical mouse models and cells. 2. Develop molecular imaging probes for imaging assays of proteins in pre-clinical models. 3. Develop imaging assays in pre-clinical models to provide to other scientists the means to guide and improve the processes for discovering new drugs. 4. Develop imaging assays in pre-clinical models for others to use in judging the impact of drugs on the biology of disease.

  6. Biology and Medicine Division annual report, 1987

    SciTech Connect (OSTI)

    Not Available

    1988-04-01

    Modern biology is characterized by rapid change. The development of new tools and the results derived from their application to various biological systems require significant shifts in our concepts and the strategies that are adopted to analyze and elucidate mechanisms. In parallel with exciting new scientific developments our organizational structure and programmatic emphases have altered. These changes and developments have enabled the life sciences at LBL to be better positioned to create and respond to new opportunities. The work summarized in this annual report reflects a vital multifaceted research program that is in the vanguard of the areas represented. We are committed to justifying the confidence expressed by LBL through the new mission statement and reorganizational changes designed to give greater prominence to the life sciences.

  7. Medicine Lake Geothermal Area | Open Energy Information

    Open Energy Info (EERE)

    Well Name: Location: Depth: Initial Flow Rate: "aa" is not declared as a valid unit of measurement for this property. The given value was not understood. Flow Test Comment:...

  8. I T E L I N E S S Secretary Bodman Visits Las Vegas

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Secretary Bodman Visits Las Vegas 1 NTS Receives First Out-of-state MLLW 3 Stephen Okosisi Goes Beyond the Call 4 Homeland Security course features guest speakers 5 Additional Security Guards Join WSI 5 Magnet Campaign Spurs Safer Drivers 6 Amchitka Marine Environment Safe 8 NNSA Works Cooperatively to Tackle Security Threats 9 Occupational Medicine Discusses Skin Cancer 10 Milestones 11 Calendar 12 In This Issue Above: Secretary Bodman toured a variety of key landmarks at the NTS, including the

  9. When DNA Needs to Stand Up and Be Counted

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    When DNA Needs to Stand Up and Be Counted Print DNA microarrays are small metal, glass, or silicon chips covered with patterns of short single-stranded DNA (ssDNA). These "DNA chips" are revolutionizing biotechnology, allowing scientists to identify and count many DNA sequences simultaneously. They are the enabling technology for genomic-based medicine and are a critical component of advanced diagnostic systems for medical and homeland security applications. Like digital chips, DNA

  10. When DNA Needs to Stand Up and Be Counted

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    When DNA Needs to Stand Up and Be Counted Print DNA microarrays are small metal, glass, or silicon chips covered with patterns of short single-stranded DNA (ssDNA). These "DNA chips" are revolutionizing biotechnology, allowing scientists to identify and count many DNA sequences simultaneously. They are the enabling technology for genomic-based medicine and are a critical component of advanced diagnostic systems for medical and homeland security applications. Like digital chips, DNA

  11. Fermilab | Science | Particle Physics | Benefits of Particle Physics |

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sciences Sciences In this Section: thumb Medicine thumb Homeland Security thumb Industry thumb Computing thumb Sciences thumb Workforce Development thumb A Growing List Synchrotron light sources Particle physicists originally built electron accelerators to explore the fundamental nature of matter. At first, they looked on the phenomenon of synchrotron radiation as a troublesome problem that sapped electrons' acceleration energy. However, they soon saw the potential to use this nuisance

  12. When DNA Needs to Stand Up and Be Counted

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    When DNA Needs to Stand Up and Be Counted Print DNA microarrays are small metal, glass, or silicon chips covered with patterns of short single-stranded DNA (ssDNA). These "DNA chips" are revolutionizing biotechnology, allowing scientists to identify and count many DNA sequences simultaneously. They are the enabling technology for genomic-based medicine and are a critical component of advanced diagnostic systems for medical and homeland security applications. Like digital chips, DNA

  13. Energy Productivity is the Best Medicine Medicine: Corporate Energy Management at Merck & Co., Inc.

    SciTech Connect (OSTI)

    2010-06-25

    Alliance to Save Energy case study on corporate energy management at Merck & Co., Inc. sponsored by the U.S. Department of Energy Industrial Technologies Program.

  14. Statement of Patricia Hoffman, Acting Assistant Secretary for Electricity Delivery and Energy Reliability Before the Subcommittee on Emerging Threats, Cyber Security and Science and Technology Committee on Homeland Security U.S. House of Representatives,

    Broader source: Energy.gov [DOE]

    Statement of Patricia Hoffman, Acting Assistant Secretary for Electricity Delivery and Energy Reliability, before the Subcommittee on Emerging Threats, Cyber Security and Science and Technology,...

  15. Proceedings of the 34th International Conference in High Energy Physics (ICHEP08), Philadelphia, PA, 2008, eConf C080730, [hep-ph/0809.xxx

    SciTech Connect (OSTI)

    Lockyer, Nigel S.; Smith, AJ Stewart,; et. al.

    2008-09-01

    In 2004 a team from the University of Pennsylvania, Princeton University, and the Institute for Advanced Study proposed to host the 2008 International Conference on High Energy Physics (ICHEP) on the campus of the University of Pennsylvania in Philadelphia. The proposal was approved later that year by the C-11 committee of the International Union of Pure and Applied Physics. The Co-Chairs were Nigel S. Lockyer (U. Penn/TRIUMF) and A.J. Stewart Smith (Princeton); Joe Kroll of U. Penn served as Deputy Chair from 2007 on. Highlights of the proposal included 1. greatly increased participation of young scientists, women scientists, and graduate students 2. new emphasis on formal theory 3. increased focus on astrophysics and cosmology 4. large informal poster session (170 posters) in prime time 5. convenient, contiguous venues for all sessions and lodging 6. landmark locations for the reception and banquet. The conference program consisted of three days of parallel sessions and three days of plenary talks.

  16. ASTA at Fermilab: Accelerator Physics and Accelerator Education Programs at the Modern Accelerator R&D Users Facility for HEP and Accelerator Applications.

    SciTech Connect (OSTI)

    Shiltsev, V.; Piot, P.

    2013-09-01

    We present the current and planned beam physics research program and accelerator education program at Advanced Superconducting Test Accelerator (ASTA) at Fermilab.

  17. Workforce Development | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Workforce Development High Energy Physics (HEP) HEP Home About Research Facilities Science ... Contact Information High Energy Physics U.S. Department of Energy SC-25Germantown ...

  18. About | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    HEP supports experiments found deep underground and in outer space, around the U.S. and across the globe. HEP also develops test facilities for future technological breakthroughs ...

  19. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    GENERAL PHYSICS; DEGREES OF FREEDOM; DETECTION; FRICTION; RESPONSE FUNCTIONS; UNIVERSE Astrophysics, Gravitation and Cosmology, Phenomenology-HEP, Theory-HEP,HEPPH, HEPTH,...

  20. Measuring the Invisible Higgs Width at the 7 and 8 TeV LHC (Journal...

    Office of Scientific and Technical Information (OSTI)

    Research Org: SLAC National Accelerator Laboratory (SLAC) Sponsoring Org: DOE Country of Publication: United States Language: English Subject: Experiment-HEP, Phenomenology-HEP,HEPPH

  1. Mission | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Cosmic Frontier Theoretical and Computational Physics ...

  2. The Office of High Energy Physics Announces the Launch of Its...

    Office of Science (SC) Website

    Community Resources News Archives 2013 The Office of High Energy Physics Announces the Launch of Its New Accelerator R&D Stewardship Webpages High Energy Physics (HEP) HEP ...

  3. Fermilab Today | Florida Institute of Technology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    electron-ion collider. WHAT SETS PARTICLE PHYSICS AT FLORIDA TECH APART? The Florida Tech HEP group has a long history of hadron collider physics, instrumentation of HEP...

  4. Accelerator R&D Stewardship | U.S. DOE Office of Science (SC...

    Office of Science (SC) Website

    High Energy Physics (HEP) HEP Home About Research Science ... Accelerator R&D to User Needs Workshop Reports Facilities ... SC programs, including Basic Energy Sciences (BES), ...

  5. Novel QCD Phenomena at JLab (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    (SLAC) Sponsoring Org: US DOE Office of Science (DOE SC);High Energy Physics (HEP) Country of Publication: United States Language: English Subject: Phenomenology-HEP,HEPPH

  6. The Holographic Entropy Cone (Journal Article) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Energy Physics (HEP) Country of Publication: United States Language: English Subject: Math and Math Physics, General Physics, Theory-HEP,HEPTH Word Cloud More Like This Full Text...

  7. Review Policy / Proposal Guidelines / Reporting Requirements| U.S. DOE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Office of Science (SC) Review Policy / Proposal Guidelines / Reporting Requirements High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Closed Funding Opportunity Announcements (FOAs) Closed Lab Announcements Award Search / Public Abstracts HEP Early Career Opportunities Review Policy / Proposal Guidelines / Reporting Requirements Additional Requirements and Guidance for Digital Data Management Acknowledgements of Federal

  8. Funding Opportunities | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Opportunities High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Closed Funding Opportunity Announcements (FOAs) Closed Lab Announcements Award Search / Public Abstracts HEP Early Career Opportunities Review Policy / Proposal Guidelines / Reporting Requirements Additional Requirements and Guidance for Digital Data Management Acknowledgements of Federal Support Advisory Committees Community Resources Contact Information High

  9. Additional Requirements and Guidance for Digital Data Management | U.S. DOE

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Office of Science (SC) Opportunities » Additional Requirements and Guidance for Digital Data Management High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Closed Funding Opportunity Announcements (FOAs) Closed Lab Announcements Award Search / Public Abstracts HEP Early Career Opportunities Review Policy / Proposal Guidelines / Reporting Requirements Additional Requirements and Guidance for Digital Data Management

  10. Jobs | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Jobs High Energy Physics (HEP) HEP Home About Organization Chart .pdf file (141KB) Staff HEP Budget HEP Committees of Visitors Directions Jobs University Research & National Labs Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More

  11. University Research National Labs | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    About » University Research & National Labs » University Research National Labs Alpha Listing High Energy Physics (HEP) HEP Home About Organization Chart .pdf file (141KB) Staff HEP Budget HEP Committees of Visitors Directions Jobs University Research & National Labs University Research National Labs Alpha Listing Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department

  12. Staff | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    About » Staff High Energy Physics (HEP) HEP Home About Organization Chart .pdf file (141KB) Staff HEP Budget HEP Committees of Visitors Directions Jobs University Research & National Labs Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us

  13. RL-2007OccupationalMedicineContractHanford.pdf

    Energy Savers [EERE]

  14. Yellow Medicine County, Minnesota: Energy Resources | Open Energy...

    Open Energy Info (EERE)

    Echo, Minnesota Granite Falls, Minnesota Hanley Falls, Minnesota Hazel Run, Minnesota Porter, Minnesota St. Leo, Minnesota Wood Lake, Minnesota Retrieved from "http:...

  15. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, Michiko; Slatkin, Daniel N.

    1997-03-18

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

  16. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, Michiko; Slatkin, Daniel N.

    1997-08-05

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

  17. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, Michiko; Slatkin, Daniel N.

    1995-10-03

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

  18. Photo of the Week: Acoustic Levitation for Medicine | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Sarah Gerrity Sarah Gerrity Former Multimedia Editor, Office of Public Affairs Every week, we'll feature our favorite energy-related photo here on Energy.gov, at Facebook.com...

  19. Mapping Fractures In The Medicine Lake Geothermal System | Open...

    Open Energy Info (EERE)

    geothermal resources in the Cascades Authors Steven Clausen, Michal Nemcok, Joseph Moore, Jeffrey Hulen and John Bartley Published GRC, 2006 DOI Not Provided Check for DOI...

  20. December 2015 Most Viewed Documents for Biology And Medicine...

    Office of Scientific and Technical Information (OSTI)

    Dept. of Psychiatry; Fowler, J.S.; Logan, J.; Wang, G.J. Brookhaven National Lab., Upton, NY (United States) (1995) 160 Drug Retention Times Center for Human Reliability Studies ...

  1. March 2016 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    Dept. of Psychiatry; Fowler, J.S.; Logan, J.; Wang, G.J. Brookhaven National Lab., Upton, NY (United States) (1995) 206 Drug Retention Times Center for Human Reliability Studies ...

  2. September 2015 Most Viewed Documents for Biology And Medicine...

    Office of Scientific and Technical Information (OSTI)

    Dept. of Psychiatry; Fowler, J.S.; Logan, J.; Wang, G.J. Brookhaven National Lab., Upton, NY (United States) (1995) 168 Drug Retention Times Center for Human Reliability Studies ...

  3. April 2013 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    Publications in biomedical and environmental sciences programs, 1981 Moody, J.B. (comp.) (1982) 306 > Drug Retention Times Center for Human Reliability Studies (2007) 99 > SURVEY ...

  4. Geodetic Survey At Medicine Lake Area (Poland, Et Al., 2006)...

    Open Energy Info (EERE)

    Date Usefulness useful DOE-funding Unknown References Michael Poland, Roland Burgmann, Daniel Dzurisin, Michael Lisowski, Timothy Masterlark, Susan Owen, Jonathan Fink (2006)...

  5. January 2013 Most Viewed Documents for Biology And Medicine ...

    Office of Scientific and Technical Information (OSTI)

    metropolitana de Sao Paulo, Brasil, utilizando a bromelia Tillandsia usneoides L. como biomonitor Nogueira, Claudio Ailton Development of simulation tools for virus shell assembly. ...

  6. Most Viewed Documents - Biology and Medicine | OSTI, US Dept...

    Office of Scientific and Technical Information (OSTI)

    Gonzalez, E.; Livengood, C. D.; Martin, K.; et al. (1999) Development of high-intensity D-D and D-T neutron sources and neutron filters for medical and industrial applications ...

  7. Stepout-Deepening Wells At Medicine Lake Area (Warpinski, Et...

    Open Energy Info (EERE)

    Technique Well Deepening Activity Date Usefulness useful DOE-funding Unknown Notes Update to Warpinski, et al., 2002 References N. R. Warpinski, A. R. Sattler, R. Fortuna, D....

  8. Static Temperature Survey At Medicine Lake Area (Warpinski, Et...

    Open Energy Info (EERE)

    Static Temperature Survey Activity Date Usefulness useful DOE-funding Unknown Notes Update to Warpinski, et al., 2002 References N. R. Warpinski, A. R. Sattler, R. Fortuna, D....

  9. 2015 DOE Annual Occupational Medicine Workshop & Webinar (OMWW...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    In addition, continuing medical education (CME) credit is awarded to participants, enabling them to maintain their medical licensure through training which is directly applicable ...

  10. Transforming Epidemiology for 21st Century Medicine and Public Health

    SciTech Connect (OSTI)

    Khoury, Muin J; Lam, Tram Kim; Ioannidis, John; Hartge, Patricia; Spitz, Margaret R.; Buring, Julie E.; Chanock, Stephen J.; Tourassi, Georgia; Zauber, Ann; Schully, Sheri D

    2013-01-01

    n 2012, the National Cancer Institute (NCI) engaged the scientific community to provide a vision for cancer epidemiology in the 21st century. Eight overarching thematic recommendations, with proposed corresponding actions for consideration by funding agencies, professional societies, and the research community emerged from the collective intellectual discourse. The themes are (i) extending the reach of epidemiology beyond discovery and etiologic research to include multilevel analysis, intervention evaluation, implementation, and outcomes research; (ii) transforming the practice of epidemiology by moving toward more access and sharing of protocols, data, metadata, and specimens to foster collaboration, to ensure reproducibility and replication, and accelerate translation; (iii) expanding cohort studies to collect exposure, clinical, and other information across the life course and examining multiple health-related endpoints; (iv) developing and validating reliable methods and technologies to quantify exposures and outcomes on a massive scale, and to assess concomitantly the role of multiple factors in complex diseases; (v) integrating big data science into the practice of epidemiology; (vi) expanding knowledge integration to drive research, policy, and practice; (vii) transforming training of 21st century epidemiologists to address interdisciplinary and translational research; and (viii) optimizing the use of resources and infrastructure for epidemiologic studies. These recommendations can transform cancer epidemiology and the field of epidemiology, in general, by enhancing transparency, interdisciplinary collaboration, and strategic applications of new technologies. They should lay a strong scientific foundation for accelerated translation of scientific discoveries into individual and population health benefits.

  11. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, M.; Slatkin, D.N.

    1997-03-18

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.

  12. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, M.; Slatkin, D.N.

    1997-08-05

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.

  13. Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy

    DOE Patents [OSTI]

    Miura, M.; Slatkin, D.N.

    1995-10-03

    A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na{sub 4}B{sub 12}I{sub 11}SSB{sub 12}I{sub 11}, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy. 1 fig.

  14. Bevatron/Bevalac user's handbook: biology and medicine. Revision

    SciTech Connect (OSTI)

    Not Available

    1985-04-01

    The Bevalac Biomedical Facility develops a source of near-relativistic heavy ions for applications to radiation biology, radiation therapy and diagnostic radiology. Pulsed beams of high LET heavy ions with variable pulse width, frequency, intensity and energy are produced and delivered to the Biomedical Facility by the Bevatron/Bevalac accelerator complex. Dosimetry equipment under computer control provides accurate determinations of absorbed doses in all regions of the Bragg curve. Depth-dose modifying devices and precise specimen positioning equipment are available. Animal housing and tissue culture facilities are convenient to the experimenter. This handbook is designed to provide the user with the relevant information for planning, proposing and executing an experiment.

  15. New radiopharmaceuticals currently used in clinical nuclear medicine

    SciTech Connect (OSTI)

    Hladik, W.B. III

    1997-12-01

    During 1996 and 1997, six new radiopharmaceuticals have been approved by the U.S. Food and Drug Administration for use in the diagnosis and/or management of patients with various disease states. Four of these new agents are antibody-based diagnostic radiotracers, and one is a therapeutic agent. One radio-pharmaceutical that has been available for several years has been approved for a new, unique indication. Our discussion focuses on the physicochemical and pharmacokinetic properties of these recently released agents as well as their specific role in the management of patients.

  16. June 2014 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    FRACTURED RESERVOIRS IN CARBONATE ROCKS: THE MICHIGAN BASIN James R. Wood; William B. Harrison (2002) 16 > Oleoresin Capsicum toxicology evaluation and hazard review Archuleta, ...

  17. Most Viewed Documents for Biology and Medicine: December 2014...

    Office of Scientific and Technical Information (OSTI)

    ... Madison, WI (US) and others (1998) 10 ADVANCED CHARACTERIZATION OF FRACTURED RESERVOIRS IN CARBONATE ROCKS: THE MICHIGAN BASIN James R. Wood; William B. Harrison (2002) 10

  18. June 2015 Most Viewed Documents for Biology And Medicine | OSTI...

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    FRACTURED RESERVOIRS IN CARBONATE ROCKS: THE MICHIGAN BASIN James R. Wood; William B. Harrison (2002) 25 Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, ...

  19. Most Viewed Documents for Biology and Medicine: September 2014...

    Office of Scientific and Technical Information (OSTI)

    FRACTURED RESERVOIRS IN CARBONATE ROCKS: THE MICHIGAN BASIN James R. Wood; William B. Harrison (2002) 14 Metabolic engineering of E.coli for the production of a precursor to ...

  20. March 2014 Most Viewed Documents for Biology And Medicine | OSTI...

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    FRACTURED RESERVOIRS IN CARBONATE ROCKS: THE MICHIGAN BASIN James R. Wood; William B. Harrison (2002) 11 > Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, ...

  1. March 2015 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    FRACTURED RESERVOIRS IN CARBONATE ROCKS: THE MICHIGAN BASIN James R. Wood; William B. Harrison (2002) 23 Control of temperature for health and productivity inoffices Seppanen, ...

  2. July 2013 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan Dorn (2002) 51 > SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE ...

  3. ORISE: Advanced Radiation Medicine | REAC/TS Continuing Medical...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    This course is not recommended for pre-hospital, emergency planning or non-medical personnel. Only brief reviews of health physics fundamentals and emergency department ...

  4. University of Medicine and Dentistry of New Jersey

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Office of Scientific and Technical Information Illinois at Urbana-Champaign Spotlights Home DOE Applauds illinois Science and Technical Programs Professors of Interest Professor Stephen P. Long is the Urbana lead Prof. John Rodgers; Flexible electronics research & Ultrathin LEDs research Prof. Benita Katzenellenbogen receives highest award of merit for her pivotal la Exceptional Students Undergrad Matthew Feickert named URA Visiting Scholar for Summer 2010 Post-doctoral researcher Susan

  5. BLACKLEAF CANYON TWO MEDICINE CREEK POTSHOT PROSPECT GLACIER E

    U.S. Energy Information Administration (EIA) Indexed Site

    BOE Reserve Class No 2001 Reserves 0.1 - 10 MBOE Basin Outline WY UT ID CO MT WA OR NV CANADA INDEX MAP ID Total Total Total Number Liquid Gas BOE of Reserves Reserves Reserves Fields (Mbbl) (MMcf) (Mbbl) Montana Thrust Belt 1 1 0 1 Basin 2001 Reserve Summary for Montana Thrust Belt Fields CANADA USA Montana Thrust Belt Oil & Gas Fields By 2001 BOE

  6. BLACKLEAF CANYON TWO MEDICINE CREEK POTSHOT PROSPECT GLACIER E

    U.S. Energy Information Administration (EIA) Indexed Site

    Gas Reserve Class No 2001 gas reserves Basin Outline WY UT ID CO MT WA OR NV CANADA INDEX MAP ID Total Total Total Number Liquid Gas BOE of Reserves Reserves Reserves Fields (Mbbl) (MMcf) (Mbbl) Montana Thrust Belt 1 1 0 1 Basin 2001 Reserve Summary for Montana Thrust Belt Fields CANADA USA Montana Thrust Belt Oil & Gas Fields By 2001 Gas

  7. BLACKLEAF CANYON TWO MEDICINE CREEK POTSHOT PROSPECT GLACIER E

    U.S. Energy Information Administration (EIA) Indexed Site

    Liquids Reserve Class No 2001 liquids reserves 0.1 - 10 Mbbl Basin Outline WY UT ID CO MT WA OR NV CANADA INDEX MAP ID Total Total Total Number Liquid Gas BOE of Reserves Reserves Reserves Fields (Mbbl) (MMcf) (Mbbl) Montana Thrust Belt 1 1 0 1 Basin 2001 Reserve Summary for Montana Thrust Belt Fields CANADA USA Montana Thrust Belt Oil & Gas Fields By 2001 Liquids

  8. Stairs, G. R. BIOLOGY AND MEDICINE; AGE; DIFFRACTION; DIFFUSION...

    Office of Scientific and Technical Information (OSTI)

    levels of radiation, but were sporadic in appearance. It is suggested that many of the radiation damaged acorns abscised from the tree and thus escaped detection. (auth) Yale...

  9. BLACKLEAF CANYON TWO MEDICINE CREEK POTSHOT PROSPECT GLACIER...

    U.S. Energy Information Administration (EIA) Indexed Site

    Liquids Reserve Class No 2001 liquids reserves 0.1 - 10 Mbbl Basin Outline WY UT ID CO MT WA OR NV CANADA INDEX MAP ID Total Total Total Number Liquid Gas BOE of Reserves Reserves ...

  10. BLACKLEAF CANYON TWO MEDICINE CREEK POTSHOT PROSPECT GLACIER...

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    BOE Reserve Class No 2001 Reserves 0.1 - 10 MBOE Basin Outline WY UT ID CO MT WA OR NV CANADA INDEX MAP ID Total Total Total Number Liquid Gas BOE of Reserves Reserves Reserves ...

  11. BLACKLEAF CANYON TWO MEDICINE CREEK POTSHOT PROSPECT GLACIER...

    U.S. Energy Information Administration (EIA) Indexed Site

    Gas Reserve Class No 2001 gas reserves Basin Outline WY UT ID CO MT WA OR NV CANADA INDEX MAP ID Total Total Total Number Liquid Gas BOE of Reserves Reserves Reserves Fields (Mbbl) ...

  12. COMPUTATIONAL SCIENCE CENTER

    SciTech Connect (OSTI)

    DAVENPORT, J.

    2005-11-01

    The Brookhaven Computational Science Center brings together researchers in biology, chemistry, physics, and medicine with applied mathematicians and computer scientists to exploit the remarkable opportunities for scientific discovery which have been enabled by modern computers. These opportunities are especially great in computational biology and nanoscience, but extend throughout science and technology and include, for example, nuclear and high energy physics, astrophysics, materials and chemical science, sustainable energy, environment, and homeland security. To achieve our goals we have established a close alliance with applied mathematicians and computer scientists at Stony Brook and Columbia Universities.

  13. TITLE AUTHORS SUBJECT SUBJECT RELATED DESCRIPTION PUBLISHER AVAILABILI...

    Office of Scientific and Technical Information (OSTI)

    Observation of a Higgs like Boson in CMS at the LHC Bhat Pushpalatha C Fermilab PHYSICS OF ELEMENTARY PARTICLES AND FIELDS Experiment HEP Experiment HEP Abstract Not Provided Fermi...

  14. Search for Low-Mass Dark Matter at BABAR Echenard, Bertrand;...

    Office of Scientific and Technical Information (OSTI)

    Low-Mass Dark Matter at BABAR Echenard, Bertrand; Caltech Experiment-HEP,HEPEX Experiment-HEP,HEPEX Abstract Not Provided http:www-public.slac.stanford.eduSciDoc...

  15. TITLE AUTHORS SUBJECT SUBJECT RELATED DESCRIPTION PUBLISHER AVAILABILI...

    Office of Scientific and Technical Information (OSTI)

    Search for Low Mass Dark Matter at BABAR Echenard Bertrand Caltech Experiment HEP HEPEX Experiment HEP HEPEX Abstract Not Provided http www public slac stanford edu SciDoc docMeta...

  16. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    VCC-1 over-expression inhibits cisplatin-induced apoptosis in HepG2 cells Zhou, Zhitao ; ... Over-expression of VCC-1 inhibit the cisplatin-provoked apoptosis in HepG2 cells. ...

  17. A Measurement

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Rev. Lett. 90 (2003). arXiv:hep-ex0212007 22 Soudan-2 collaboration, W. W. M. Allison et al., Phys. Lett. B 449:137 (1999). arXiv:hep- ex9901024 23 CHOOZ ...

  18. /Fermilab 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS Experiment...

    Office of Scientific and Technical Information (OSTI)

    a Higgs-like Boson in CMS at the LHC Bhat, Pushpalatha C.; Fermilab 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS Experiment-HEP Experiment-HEP Abstract Not Provided Fermi...

  19. SLAC-PUB-15178 July

    Office of Scientific and Technical Information (OSTI)

    D. Zep- penfeld, Phys. Rev. D 70, 113009 (2004) hep-ph0406323, hep-ph0407190. 7 R. Lafaye, T. Plehn, M. Rauch, D. Zerwas and M. D uhrssen, JHEP 08 (2009) 009...

  20. Workshop Agenda

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9:00 am HEP Program Office Research Directions Amber Boehnlein, DOE HEP 9:30 am NERSC Role in High Energy Physics Research Kathy Yelick, NERSC Director 10:15 am Break 10:30 pm...

  1. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Datasets0 Filter Results Filter by Subject theory-hep,hepth (4) theory-hep,hepth, math (1) Filter by Author Dixon, Lance J. (6) von Hippel, Matt (6) Bern, Zvi (2) Douglas,...

  2. Find Funding | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Biological & Environmental Research (BER) funding opportunities information Fusion Energy Sciences (FES) funding opportunities information High Energy Physics (HEP) ...

  3. Community Resources | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Resources High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources News Archives Reports HEP Sponsored Workshops and Conferences Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » Community Resources Print Text Size: A A A FeedbackShare Page

  4. Information for Investigators | U.S. DOE Office of Science (SC)

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    Information for Investigators High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Cosmic Frontier Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Background Awards Information for Investigators Test Facility Pilot Program Workshop Reports Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics

  5. Accelerator Stewardship | U.S. DOE Office of Science (SC)

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    Accelerator Stewardship High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Cosmic Frontier Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Background Awards Information for Investigators Test Facility Pilot Program Workshop Reports Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S.

  6. Before the House Subcommittee on Counterterrorism and Intelligence...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Counterterrorism and Intelligence - Committee on Homeland Security Before the House Subcommittee on Counterterrorism and Intelligence - Committee on Homeland Security Before the...

  7. Atcitty_Ultra-HighSIC_RD100v8.2.indd

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... the Department of Energy, Navy, Army, DARPA, and the Department of Homeland Security. ... the Department of Energy, Navy, Army, DARPA, and the Department of Homeland Security. ...

  8. Exercise Program | National Nuclear Security Administration

    National Nuclear Security Administration (NNSA)

    Organization Categorization & Classification Notifications & Communications ... HQ Emergency Management Team (EMT) Homeland Security and Emergency Management Coordination ...

  9. Algal Biofuels Can Make a Difference (Presentation)

    SciTech Connect (OSTI)

    Pienkos, P.

    2012-03-01

    Presentation given at the 2012 Department of Homeland Security Renewable Energy Roundtable on Algal Fuels.

  10. Science and Technology Review March 2012

    SciTech Connect (OSTI)

    Nikolic, R J

    2012-02-15

    This month's issue has the following articles: (1) Honoring a Legacy of Service to the Nation - The nation pays tribute to George Miller, who retired in December 2011 as the Laboratory's tenth director; (2) Life-Extension Programs Encompass All Our Expertise - Commentary by Bruce T. Goodwin; (3) Extending the Life of an Aging Weapon - Stockpile stewards have begun work on a multiyear effort to extend the service life of the aging W78 warhead by 30 years; (4) Materials by Design - Material microstructures go three-dimensional with improved additive manufacturing techniques developed at Livermore; (5) Friendly Microbes Power Energy-Producing Devices - Livermore researchers are demonstrating how electrogenic bacteria and microbial fuel cell technologies can produce clean, renewable energy and purify water; and (6) Chemical Sensor Is All Wires, No Batteries - Livermore's 'batteryless' nanowire sensor could benefit applications in diverse fields such as homeland security and medicine.

  11. NETL's High-Speed Imaging System Successfully Applied in Medicine, Broad Spectrum of Industry

    Broader source: Energy.gov [DOE]

    A groundbreaking Department of Energy-developed imaging system originally designed to help create cleaner fossil energy processes is finding successful applications in a wide range of medical, chemical processing, energy, and other industries.

  12. DOSFAC2 user`s guide Young, M.L.; Chanin, D. 56 BIOLOGY AND MEDICINE...

    Office of Scientific and Technical Information (OSTI)

    and (3) a users guide. 20 refs., 5 tabs. INIS; OSTI as TI97008490 Nuclear Regulatory Commission, Washington, DC (United States). Div. of Systems Technology; Sandia...

  13. Structure of Chinese Herbal-based Medicine Captured by ATP on...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Thursday, October 31, 2013 For thousands of years the Chinese have been using the Chang Shan herb (Dichroa febrifuga Lour) to treat malaria-induced fevers (1). The active...

  14. Nuclear medicine program progress report for quarter ending September 30, 1996

    SciTech Connect (OSTI)

    Knapp, F.F. Jr.; Ambrose, K.R.; Beets, A.L.; Boll, R.; Luo, H.; McPherson, D.W.; Mirzadeh, S.

    1997-01-01

    The reactor production yields of tungsten-188 produced by neutron capture by enriched tungsten-186 in the HFIR and other reactors are nearly an order of magnitude lower than expected by calculation using established cross section values. Since neutron capture of tungsten-188 may be the major factor which significantly reduces the observed yields of tungsten-188, the authors have evaluated the possible burn-up cross section of the tungsten-188 product. Tungsten-189 was produced by irradiating a radioactive target containing a known amount of {sup 188}W. In order to reduce the radiation level to an acceptable level (<20% detector dead time), the authors chemically removed >90% of {sup 188}Re, which is the decay product of {sup 188}W, prior to irradiation. They were able to confirm the two predominant {gamma}-rays in the decay of {sup 189}W, 260.1 {+-} 1.4 and 421.5 {+-} 1.6 keV. By following the decay of these {gamma}-rays in two sets of experiments, a half-life of 10.8 {+-} 0.3 m was obtained for {sup 189}W. Based on a knowledge of the {sup 188}W content of target (52.6 mBq), neutron flux of 5 {times} 10{sup 13} n {center_dot} s{sup {minus}1} {center_dot} cm{sup {minus}2}, irradiation time of 10 min and with the assumption of 100% intensity for 260.1 and 421.5 keV {gamma}-rays, a cross-section of 12.0 {+-} 2.5 b was calculated for burn-up cross-section of {sup 188}W, which helps explain the greatly reduced production yields of {sup 188}W.

  15. InSAR At Medicine Lake Area (Poland, Et Al., 2006) | Open Energy...

    Open Energy Info (EERE)

    Date Usefulness useful DOE-funding Unknown References Michael Poland, Roland Burgmann, Daniel Dzurisin, Michael Lisowski, Timothy Masterlark, Susan Owen, Jonathan Fink (2006)...

  16. Water-soluble carbon nanotube compositions for drug delivery and medicinal applications

    DOE Patents [OSTI]

    Tour, James M.; Lucente-Schultz, Rebecca; Leonard, Ashley; Kosynkin, Dmitry V.; Price, Brandi Katherine; Hudson, Jared L.; Conyers, Jr., Jodie L.; Moore, Valerie C.; Casscells, S. Ward; Myers, Jeffrey N.; Milas, Zvonimir L.; Mason, Kathy A.; Milas, Luka

    2014-07-22

    Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.

  17. EA-0965: Cancer Research Center Indiana University School of Medicine, Argonne, Illinois

    Broader source: Energy.gov [DOE]

    This EA evaluates the environmental impacts of the proposal to construct and equip the proposed Cancer Research Center (CRC), which would be located on the Indianapolis campus of the Indiana...

  18. GUIDELINES FOR BREASTFEEDING MOTHERS IN NUCLEAR MEDICINE LATEST REVISION DATE: 9/3/96

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GTRI: Reducing Nuclear Threats May 29, 2014 Mission In 2004 NNSA established the Global Threat Reduction Initiative (GTRI) in the Office of Defense Nuclear Nonproliferation to, as quickly as possible, identify, secure, remove and/or facilitate the disposition of high risk vulnerable nuclear and radiological materials around the world that pose a threat to the United States and the international community. GTRI's mission is to reduce and protect vulnerable nuclear and radiological material

  19. Nanoparticles of spinel and perovskite ferromagnets and prospects for their application in medicine

    SciTech Connect (OSTI)

    Belous, A. G. E-mail: solopan@ukr.net Solopan, S. O. E-mail: solopan@ukr.net Yelenich, O. V. E-mail: solopan@ukr.net; Tovstolytkin, A. I.; Kolodiazhnyi, T. V.; Osinsky, S. P. E-mail: bybnovskayal@ukr.net; Bubnovskaya, L. N. E-mail: bybnovskayal@ukr.net

    2014-11-05

    In this work, nanoparticles of La{sub 0.75}Sr{sub 0.25}MnO{sub 3} compounds with perovskite structure and AFe{sub 2}O{sub 4} (A = Mn, Fe, Co, Ni, Zn) with spinel structure have been synthesized by precipitation from diethylene glycol and microemulsion using Triton X-100 surfactant. Comparative X-ray diffraction and magnetic studies of the synthesized nanoparticles have been carried out. Magnetic fluids prepared from synthesized nanopowders have been characterized by calorimetric measurements of specific loss power (SLP)

  20. 3D dose and TCP distribution for radionuclide therapy in nuclear medicine

    SciTech Connect (OSTI)

    Valente, M.; Malano, F.; Perez, P.

    2010-08-04

    A common feature to any radiant therapy is that lesion and health tissue dosimetry provides relevant information for treatment optimization along with dose-efficacy and dose-complication correlation studies. Nowadays, different radionuclide therapies are commonly available, assessing both systemic and loco-regional approach and using different alfa-, beta-and gamma-emitting isotopes and binding molecules. It is well established, that specific dosimetric approaches become necessary according to each therapy modality. Sometimes, observed activity distribution can be satisfactory represented by simple geometrical models. However, Monte Carlo techniques are capable of better approaches, therefore becoming sometimes the only way to get dosimetric data since the patient-specific situation can not be adequately represented by conventional dosimetry techniques. Therefore, due to strong limitations of traditional and standard methods, this work concentrates on the development of a dedicated and novel calculation system in order to assess the dose distribution within the irradiated patient. However, physical dose may not be enough information in order to establish real deterministic biological/metabolic effects; therefore complementary radiobiological models have been suitably introduced with the aim of performing realistic 3D dose as well as corresponding Tumor Control Probability distribution calculation.

  1. Theoretical and Computational Physics | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Theoretical and Computational Physics High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Cosmic Frontier Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW

  2. Experiments | U.S. DOE Office of Science (SC)

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    Cosmic Frontier » Experiments High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Cosmic Frontier Experiments Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW

  3. Experiments | U.S. DOE Office of Science (SC)

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    Energy Frontier » Experiments High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Experiments Intensity Frontier Cosmic Frontier Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW

  4. Experiments | U.S. DOE Office of Science (SC)

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    Intensity Frontier » Experiments High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Experiments Cosmic Frontier Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW

  5. Facility for Advanced Accelerator Experimental Tests (FACET) | U.S. DOE

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    Office of Science (SC) Facility for Advanced Accelerator Experimental Tests (FACET) High Energy Physics (HEP) HEP Home About Research Facilities User Facilities Fermilab Accelerator Complex Facility for Advanced Accelerator Experimental Tests (FACET) Accelerator Test Facility (ATF) Facility Ops Projects, Missions, and Status Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy

  6. Fermilab Accelerator Complex | U.S. DOE Office of Science (SC)

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    Fermilab Accelerator Complex High Energy Physics (HEP) HEP Home About Research Facilities User Facilities Fermilab Accelerator Complex Facility for Advanced Accelerator Experimental Tests (FACET) Accelerator Test Facility (ATF) Facility Ops Projects, Missions, and Status Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington,

  7. Science Highlights | U.S. DOE Office of Science (SC)

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    Highlights High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » Science Highlights Print Text Size: A A A Subscribe FeedbackShare Page Filter by Performer Or press Esc Key to close. close

  8. Test Facility Pilot Program | U.S. DOE Office of Science (SC)

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    Test Facility Pilot Program High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Cosmic Frontier Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Background Awards Information for Investigators Test Facility Pilot Program Workshop Reports Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S.

  9. The Daya Bay Reactor Neutrino Experiment Sees Evidence that Electron

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Neutrinos Turn into Muon Neutrinos | U.S. DOE Office of Science (SC) The Daya Bay Reactor Neutrino Experiment Sees Evidence that Electron Neutrinos Turn into Muon Neutrinos High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F:

  10. Patterns in the Cosmos Trace Evolution of the Universe | U.S. DOE Office of

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    Science (SC) Patterns in the Cosmos Trace Evolution of the Universe High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » 08.01.13 Patterns in the Cosmos Trace Evolution of the

  11. Background | U.S. DOE Office of Science (SC)

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    Background High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Cosmic Frontier Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Background Awards Information for Investigators Test Facility Pilot Program Workshop Reports Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of

  12. LBNL Scientist Shares 2011 Physics Nobel Prize | U.S. DOE Office of Science

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    (SC) LBNL Scientist Shares 2011 Physics Nobel Prize High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » 10.01.12 LBNL Scientist Shares 2011 Physics Nobel Prize Astrophysicist Saul

  13. Documents

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Documents Documents Sort by: Default | Name | Date (low-high) | Date (high-low) | Source | Category White Paper Template May 7, 2015 | Download File: HEP-White-Papers-Public2.pdf | pdf | 78 KB Download File: ASCRHEPReqRevWPtemplate.docx | docx | 136 KB HEP Exascale Requirements Review Case Study Template June 2, 2015 | Download File: CaseStudyTemplate-HEPrev.docx | docx | 28 KB HEP Exascale Requirements Review Case Study Template Last edited: 2016-04-29 11:34:52

  14. Energy Frontier | U.S. DOE Office of Science (SC)

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    Energy Frontier High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Experiments Intensity Frontier Cosmic Frontier Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC

  15. Supercomputing on a Budget | U.S. DOE Office of Science (SC)

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    Supercomputing on a Budget High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » 06.01.13 Supercomputing on a Budget The optimization of commercial hardware and specialized software

  16. News and Resources | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    News and Resources High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » News and Resources Print Text Size: A A A FeedbackShare Page The address you entered is no longer valid. Please

  17. A Nobel for Neutrinos: Super-Kamiokande | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Highlights » 2015 » A Nobel for Neutrinos: Super-Kamiokande High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » 11.01.15 A Nobel for Neutrinos: Super-Kamiokande Discovery of neutrino

  18. Facilities | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Facilities High Energy Physics (HEP) HEP Home About Research Facilities User Facilities Facility Ops Projects, Missions, and Status Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » Facilities Print Text Size: A A A FeedbackShare Page The

  19. Featured Content | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Featured Content High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Featured Content 2016 2015 2014 2013 2012-2008 Reports Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » Community Resources Featured Content Print Text Size: A A A

  20. Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Presentations Presentations Sort by: Default | Name | Date (low-high) | Date (high-low) | Source | Category Barbara Helland: NERSC-HEP Requirements Review November 27, 2012 | Author(s): Barbara Helland | Download File: Helland.pdf | pdf | 5.5 MB NERSC-HEP Requirements Review James Siegrist: Perspectives from High Energy Physics November 27, 2012 | Author(s): James Siegrist | Download File: Siegrist-HEP-Overview.pdf | pdf | 3.7 MB Perspectives from High Energy Physics Sudip Dosanjh: NERSC Role in

  1. Research | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Research High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Cosmic Frontier Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301)

  2. Intensity Frontier| U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Intensity Frontier High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Experiments Cosmic Frontier Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC

  3. Advisory Committees | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Advisory Committees High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees HEPAP AAAC External link Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » Advisory Committees Print Text Size: A A A FeedbackShare Page High Energy Physics

  4. Design and operation of the high energy physics information server

    SciTech Connect (OSTI)

    Dingbaum, J.J.; Martin, D.E.

    1994-12-31

    HEPIC an information {open_quotes}center of centers{close_quotes} for the HEP community, is a 24 hour online location where a HEP researcher can start her/his search for information. Operated by the HEP Network Research Center, HEPIC is accessible via WWW, gopher, anonymous FTP, DECnet, and AFS. This paper describes HEPIC`s design and future plans, and the HEPNRC`s efforts to collect information and link high energy physics researchers world-wide.

  5. The Office of High Energy Physics Announces the Launch of Its New

    Office of Science (SC) Website

    Accelerator R&D Stewardship Webpages | U.S. DOE Office of Science (SC) Community Resources » Featured Content » 2013 » The Office of High Energy Physics Announces the Launch of Its New Accelerator R&D Stewardship Webpages High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Featured Content 2016 2015 2014 2013 2012-2008 Reports Contact Information High Energy Physics U.S.

  6. 2015 | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » Science Highlights 2015 Print Text Size: A A A FeedbackShare Page Filter by Performer Or press Esc Key to close. close Select all

  7. Universe in a (Blue) Bottle | U.S. DOE Office of Science (SC)

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    Universe in a (Blue) Bottle High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » 10.01.12 Universe in a (Blue) Bottle Simulating the evolution of the universe on the Argonne Leadership

  8. User Facilities | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Facilities High Energy Physics (HEP) HEP Home About Research Facilities User Facilities Fermilab Accelerator Complex Facility for Advanced Accelerator Experimental Tests (FACET) Accelerator Test Facility (ATF) Facility Ops Projects, Missions, and Status Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301)

  9. Accelerator Test Facility (ATF) | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerator Test Facility (ATF) High Energy Physics (HEP) HEP Home About Research Facilities User Facilities Fermilab Accelerator Complex Facility for Advanced Accelerator Experimental Tests (FACET) Accelerator Test Facility (ATF) Facility Ops Projects, Missions, and Status Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW

  10. Advances in High Power Compact Accelerators | U.S. DOE Office of Science

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    (SC) 4 » Advances in High Power Compact Accelerators High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » 04.01.14 Advances in High Power Compact Accelerators Argonne superconducting

  11. Cosmic Frontier | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cosmic Frontier High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Cosmic Frontier Experiments Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC

  12. Awards | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Awards High Energy Physics (HEP) HEP Home About Research Science Drivers of Particle Physics Energy Frontier Intensity Frontier Cosmic Frontier Theoretical and Computational Physics Advanced Technology R&D Accelerator Stewardship Background Awards Information for Investigators Test Facility Pilot Program Workshop Reports Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy

  13. BELLA World Record Sets Stage for Laser Experiments in Novel Acceleration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Techniques | U.S. DOE Office of Science (SC) BELLA World Record Sets Stage for Laser Experiments in Novel Acceleration Techniques High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information »

  14. A Simple Harmonic Universe (Technical Report) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    RELATIVITY THEORY; HARMONICS; PARTICLE PRODUCTION; UNIVERSE Theory-HEP,HEPPH, HEPTH, ASTRO, GRQC Word Cloud More Like This Full Text preview image File size NAView Full Text...

  15. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    of Science (SC), High Energy Physics (HEP) (SC-25)","43 PARTICLE ACCELERATORS; BEAM OPTICS; CHANNELING; ATTENUATION; BEAM EXTRACTION; BENDING; CRYSTALS; MESON BEAMS; BEAMS;...

  16. The Fermilab Main Injector: high intensity operation and beam...

    Office of Scientific and Technical Information (OSTI)

    Title: The Fermilab Main Injector: high intensity operation and beam loss control Authors: ... Sponsoring Org: USDOE Office of Science (SC), High Energy Physics (HEP) (SC-25) Country of ...

  17. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... involved in development of novel scintillating crystals and has proposed several crystal based detector concepts for future HEP experiments at the energy and intensity frontiers. ...

  18. High Energy Physics Division, ANL Lattice QCD

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Energy Physics Division, ANL Lattice QCD in extreme environments D. K. Sinclair (HEP, Argonne) J. B. Kogut (Physics, Illinois) D. Toublan (Physics, Illinois) 1 Lattice QCD Quantum ...

  19. Statement of Dr. Lynn Orr

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... protection from manmade and natural threats, are necessary for a modern and reliable grid. ... of fusion energy. * High Energy Physics (HEP) supports research to understand how ...

  20. Charmless Three-Body $B$ Decays at BABAR (Conference) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Conference: Charmless Three-Body B Decays at BABAR Citation Details In-Document Search ... Country of Publication: United States Language: English Subject: Experiment-HEP,HEPEX Word ...

  1. Workshop Reports | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Background Awards Information for Investigators Test Facility Pilot Program Workshop Reports Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees ...

  2. Computational Astrophysics Consortium 3 - Supernovae, Gamma-Ray...

    Office of Scientific and Technical Information (OSTI)

    Sponsoring Org: USDOE NP, OASCR, NNSA, HEP Country of Publication: United States Language: English Subject: 79 ASTRONOMY AND ASTROPHYSICS SciDAC 2, Computational Astrophysics ...

  3. "Title","Creator/Author","Publication Date","OSTI Identifier...

    Office of Scientific and Technical Information (OSTI)

    Energy Physics (HEP) (SC-25)","79 ASTRONOMY AND ASTROPHYSICS Dark Energy, Type Ia supernovae, radiative transfer,",,"The progress over the course of the grant period was...

  4. A Gravity Dual of Metastable Dynamical Supersymmetry Breaking...

    Office of Scientific and Technical Information (OSTI)

    Subject: 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS; DUALITY; EXPECTATION VALUE; RENORMALIZATION; SUPERGRAVITY; SUPERSYMMETRY; SYMMETRY BREAKING; SU GROUPS Theory-HEP,HEPTH...

  5. Workshop Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Modeling Efforts of the ComPASSSciDAC Projects November 12, 2009 | Author(s): David Bruhwiler | HEP Detector Simulation and Analysis November 12, 2009 | Author(s):...

  6. Participants

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Role Lali Chatterjee DOE HEP Program Manager Computational High Energy Physics David Goodwin DOE ASCR NERSC Program Manager Sudip Dosanjh NERSC NERSC Director Richard...

  7. The CP-Violating pMSSM at the Intensity Frontier (Conference...

    Office of Scientific and Technical Information (OSTI)

    National Accelerator Laboratory (SLAC) Sponsoring Org: US DOE Office of Science (DOE SC) Country of Publication: United States Language: English Subject: Experiment-HEP, ...

  8. pMSSM Benchmark Models for Snowmass 2013 (Journal Article) |...

    Office of Scientific and Technical Information (OSTI)

    National Accelerator Laboratory (SLAC) Sponsoring Org: US DOE Office of Science (DOE SC) Country of Publication: United States Language: English Subject: Experiment-HEP, ...

  9. Searches with Mono-Leptons (Journal Article) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    National Accelerator Laboratory (SLAC) Sponsoring Org: US DOE Office of Science (DOE SC) Country of Publication: United States Language: English Subject: Experiment-HEP, ...

  10. Global search for new physics at CDF (Conference) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Research Org: Fermi National Accelerator Laboratory (FNAL), Batavia, IL Sponsoring Org: ... PARTICLES AND FIELDS; FERMILAB COLLIDER DETECTOR; PHYSICS; SUPERSYMMETRY Experiment-HEP

  11. Chiral Anomaly Effects And the BaBar Measurements of the$\\gamma...

    Office of Scientific and Technical Information (OSTI)

    National Accelerator Laboratory (SLAC) Sponsoring Org: US DOE Office of Science (DOE SC) Country of Publication: United States Language: English Subject: Experiment-HEP, ...

  12. Resummation of Relativistic Corrections to Exclusive Productions...

    Office of Scientific and Technical Information (OSTI)

    National Accelerator Laboratory (SLAC) Sponsoring Org: US DOE Office of Science (DOE SC);KIAS Country of Publication: United States Language: English Subject: Experiment-HEP, ...

  13. Charmless B Decays at BaBar and Belle (Conference) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Accelerator Laboratory (SLAC) Sponsoring Org: US DOE Office of Science (DOE SC) Country of Publication: United States Language: English Subject: Experiment-HEP,HEPEX Word ...

  14. Inelastic Dark Matter at the LHC (Journal Article) | SciTech...

    Office of Scientific and Technical Information (OSTI)

    Accelerator Laboratory (SLAC) Sponsoring Org: US DOE Office of Science (DOE SC) Country of Publication: United States Language: English Subject: Astrophysics, Experiment-HEP, ...

  15. The New Look pMSSM with Neutralino and Gravitino LSPs (Journal...

    Office of Scientific and Technical Information (OSTI)

    Laboratory (SLAC) Sponsoring Org: US DOE Office of Science (DOE SC);High Energy Physics (HEP) Country of Publication: United States Language: English Subject: Experiment-HE...

  16. Bounding gauged skyrmion masses (Journal Article) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Sponsoring Org: USDOE Office of Science (SC), High Energy Physics (HEP) (SC-25) Country of Publication: United States Language: English Word Cloud More Like This Full Text File ...

  17. Charm Production by Neutrinos (Journal Article) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Sponsoring Org: USDOE Office of Science (SC), High Energy Physics (HEP) (SC-25) Country of Publication: United States Language: English Word Cloud More Like This Full Text preview ...

  18. Light Higgs And Dark Photon Searches at BABAR (Conference) |...

    Office of Scientific and Technical Information (OSTI)

    Several new-physics (NP) models predict the existence of low-mass Higgs states and light ... (HEP) Contributing Orgs: BABAR Collaboration Country of Publication: United States ...

  19. Department

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    HEP production computing requirements over the next 5-10 years at NERSC, the National Energy Research Scientific Computing Center. NERSC is the principal provider of production...

  20. Computational Astrophysics Consortium 3 - Supernovae, Gamma-Ray...

    Office of Scientific and Technical Information (OSTI)

    Resource Type: Technical Report Research Org: The Regents of the University of California, Santa Cruz Sponsoring Org: USDOE NP, OASCR, NNSA, HEP Country of Publication: United ...

  1. TITLE AUTHORS SUBJECT SUBJECT RELATED DESCRIPTION PUBLISHER AVAILABILI...

    Office of Scientific and Technical Information (OSTI)

    Cass Avenue HEP Argonne IL United States E mail zachos anl gov CLASSICAL AND QUANTUM MECHANICS GENERAL PHYSICS COMPACTIFICATION DUALITY FERMIONS GAUGE INVARIANCE HOLOGRAPHY MANY...

  2. FACET-II Science Opportunities Workshops Summary Report (Conference...

    Office of Scientific and Technical Information (OSTI)

    (SLAC) Sponsoring Org: US DOE Office of Science (DOE SC);High Energy Physics (HEP) Country of Publication: United States Language: English Subject: ACCPHY, INST, OPTICS, PHYS, XFEL

  3. An Automated Implementation of On-shell Methods for One-Loop...

    Office of Scientific and Technical Information (OSTI)

    Review D Research Org: Stanford Linear Accelerator Center (SLAC) Sponsoring Org: USDOE Country of Publication: United States Language: English Subject: Phenomenology-HEP,HEPPH

  4. Nambu--Goldstone Dark Matter and Cosmic Ray Electron and Positron...

    Office of Scientific and Technical Information (OSTI)

    Subject: 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS; BOSONS; ELECTRONS; LEPTONS; NONLUMINOUS MATTER; POSITRONS; RESONANCE; SUPERSYMMETRY Phenomenology-HEP,HEPPH, HEPTH Word ...

  5. Electroweak and QCD corrections to top-pair hadroproduction in...

    Office of Scientific and Technical Information (OSTI)

    Country of Publication: United States Language: English Subject: Phenomenology-HEP,HEPPH Word Cloud More Like This Full Text preview image File size NAView Full Text View Full ...

  6. Comprehensive Monitoring for Heterogeneous Geographically Distributed...

    Office of Scientific and Technical Information (OSTI)

    Comprehensive Monitoring for Heterogeneous Geographically Distributed Storage Citation ... Sponsoring Org: USDOE Office of Science (SC), High Energy Physics (HEP) (SC-25) Country of ...

  7. Observation of a Higgs-like Boson in CMS at the LHC (Conference...

    Office of Scientific and Technical Information (OSTI)

    Batavia, IL Sponsoring Org: DOE Office of Science Country of Publication: United States Language: English Subject: 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS Experiment-HEP...

  8. Review Policy / Proposal Guidelines / Reporting Requirements...

    Office of Science (SC) Website

    ... most recent Comparative Review FOA, please go to the HEP Funding Opportunities web page. ... assistance award, please view the Office of Science's Funding Opportunities web page. ...

  9. Previous Meetings | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Previous Meetings High Energy Physics Advisory Panel (HEPAP) HEPAP Home Meetings Previous Meetings 2016 HEPAP Membership ChargesReports Charter .pdf file (44KB) HEP Committees of ...

  10. Precision measurement of the top quark mass in the lepton + jets...

    Office of Scientific and Technical Information (OSTI)

    ... FERMILAB TEVATRON; INTERMEDIATE BOSONS; LEPTONS; LUMINOSITY; MATRIX ELEMENTS; NEURAL NETWORKS; QUARKS; RESOLUTION; T QUARKS Experiment-HEP Word Cloud More Like This Full Text ...

  11. Precision measurement of the top quark mass in the lepton + jets...

    Office of Scientific and Technical Information (OSTI)

    FERMILAB TEVATRON; INTERMEDIATE BOSONS; LEPTONS; LUMINOSITY; MATRIX ELEMENTS; NEURAL NETWORKS; QUARKS; RESOLUTION; T QUARKS Experiment-HEP Word Cloud More Like This Full Text ...

  12. Electroweak production of top-quark pairs in e+e- annihilation...

    Office of Scientific and Technical Information (OSTI)

    As a result, we demonstrate the power of our technique by considering its application to ... Country of Publication: United States Language: English Subject: phenomenology-HEP; HEPPH ...

  13. Search for: All records | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    ... deployment, and operation of the data analysis infrastructure for HEP and NP ... studies that have limited statistics in the upper endmore of the mass range. ...

  14. PTF, LSSN, BOSS, Nyx!

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    HEP NERSC Review Turn-around UCB machine learning algorithm is applied to all ... BAO experiments are being set up to measure these signals through the cataloging of ...

  15. Preparing for Harvesting Radioisotopes from FRIB

    SciTech Connect (OSTI)

    Peaslee, Graham F.; Lapi, Suzanne E.

    2015-02-02

    The Facility for Rare Isotope Beams (FRIB) is the next generation accelerator facility under construction at Michigan State University. FRIB will produce a wide variety of rare isotopes by a process called projectile fragmentation for a broad range of new experiments when it comes online in 2020. The accelerated rare isotope beams produced in this facility will be more intense than any current facility in the world - in many cases by more than 1000-fold. These beams will be available to the primary users of FRIB in order to do exciting new fundamental research with accelerated heavy ions. In the standard mode of operation, this will mean one radioisotope will be selected at a time for the user. However, the projectile fragmentation process also yields hundreds of other radioisotopes at these bombarding energies, and many of these rare isotopes are long-lived and could have practical applications in medicine, national security or the environment. This project developed new methods to collect these long-lived rare isotopes that are by-products of the standard FRIB operation. These isotopes are important to many areas of research, thus this project will have a broad impact in several scientific areas including medicine, environment and homeland security.

  16. ORISE: ORISE is accepting applications for the 2015 U.S. Department of

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Homeland Security Summer Internship Program U.S. Department of Homeland Security Summer Internship Program Program represents opportunity for students to perform research at federal facilities located across the U.S. FOR IMMEDIATE RELEASE Nov. 20, 2014 FY15-04 OAK RIDGE, Tenn.-ORISE is currently accepting applications for the 2015 U.S. Department of Homeland Security HS-STEM Summer Internship Program, which is a 10-week summer internship program for students majoring in homeland

  17. United States Government

    Energy Savers [EERE]

    Energy memorandum DATE: April 9, 2004 Audit Report Number: OAS-L-04-13 REPLY TO ATTN OF: IG-35 (A04DC009) SUBJECT: Audit Report on "Reimbursable Work for the Department of Homeland Security" TO: Administrator, National Nuclear Security Administration, NA-1 INTRODUCTION AND OBJECTIVE The Homeland Security Act of 2002 authorizes the Department of Homeland Security (Homeland Security) to utilize the capabilities of the Department of Energy's (Department) laboratories and other sites to

  18. Gregory H. Friedman: Provided for the Subcommittee on Financial and

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Contracting Oversight Committee on Homeland Security and Governmental Affairs | Department of Energy Financial and Contracting Oversight Committee on Homeland Security and Governmental Affairs Gregory H. Friedman: Provided for the Subcommittee on Financial and Contracting Oversight Committee on Homeland Security and Governmental Affairs June 27, 2013 Gregory H. Friedman: Provided for the Subcommittee on Financial and Contracting Oversight Committee on Homeland Security and Governmental

  19. Sandia National Laboratories: News: Publications: Lab Accomplishments

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    Bioscience Community involvement, customers relations, and institutional development ... and management Homeland security HR & Finance IT, networks, and facilities Materials ...

  20. Contacts | NISAC

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    National Laboratories Department of Homeland Security Los Alamos National Laboratory Program Manager Sandia National Laboratories Resilient Infrastructure Systems Bill Rhodes...

  1. Before the House Subcommittee on Emerging Threats, Cyber Security...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Homeland Security By: Patricia Hoffman, Acting Assistant Secretary for Electricity ... More Documents & Publications Statement of Patricia Hoffman, Acting Assistant Secretary ...

  2. Renewable Energy 101 (Presentation)

    SciTech Connect (OSTI)

    Walker, A.

    2012-03-01

    Presentation given at the 2012 Department of Homeland Security Renewable Energy Roundtable as an introduction to renewable technologies and applications.

  3. Elementary Particle Physics at Baylor (Final Report)

    SciTech Connect (OSTI)

    Dittmann, J.R.

    2012-08-25

    This report summarizes the activities of the Baylor University Experimental High Energy Physics (HEP) group on the Collider Detector at Fermilab (CDF) experiment from August 15, 2005 to May 31, 2012. Led by the Principal Investigator (Dr. Jay R. Dittmann), the Baylor HEP group has actively pursued a variety of cutting-edge measurements from proton-antiproton collisions at the energy frontier.

  4. 4He Cross Section

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    p, X) (Current as of 03/01/2016) NSR Reaction Ep (MeV) Cross Section File X4 Dataset Date Added 1974KR07 4He(p, p): σ 0.5 - 3 X4 10/23/2014 2004PU02 4He(p, p): σ(θ = 128.7°) 1.2 - 5.2 X4 10/23/2014 1997NU02 4He(p, p): σ 1.4 - 6 X4 10/23/2014 1976BR17 4He(p, p): σ(168.8°)/σ(104.4°) 2.24 - 5.90 X4 10/23/2014 1977DO01 4He(p, p): σ 11 - 14 X4 10/23/2014 1969GA12 4He(p, p): σ 12.04, 14.23, 17.45 X4 10/23/2014 1974SO06 4He(p, X): total reaction σ 18 - 48 1 03/08/2011 1976SO01 4He(p, X),

  5. 3He Cross Section

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    3He(pol. p, +): differential 200, 300, 400 X4 10302014 1985EP01 3He(p, 2p), (p, pd): 300, 450 X4 10302014 1977FR05 3He(p, p): differential 415, 600, 800 cm ...

  6. Sandia National Laboratories: National Security Missions: International

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    Homeland and Nuclear Security: Homeland Security Axis Programs Homeland Security HDPF We develop advanced technologies for detecting radiological and nuclear sources. We formulate innovative concepts for biological agent warning and response, decontamination, and medical diagnostics. We support emergency management training, preparedness, and response to catastrophic incidents. We provide equipment for safely destroying chemical weapons to meet treaty obligations. We are committed to

  7. Compelling Research Opportunities using Isotopes

    SciTech Connect (OSTI)

    2009-04-23

    Isotopes are vital to the science and technology base of the US economy. Isotopes, both stable and radioactive, are essential tools in the growing science, technology, engineering, and health enterprises of the 21st century. The scientific discoveries and associated advances made as a result of the availability of isotopes today span widely from medicine to biology, physics, chemistry, and a broad range of applications in environmental and material sciences. Isotope issues have become crucial aspects of homeland security. Isotopes are utilized in new resource development, in energy from bio-fuels, petrochemical and nuclear fuels, in drug discovery, health care therapies and diagnostics, in nutrition, in agriculture, and in many other areas. The development and production of isotope products unavailable or difficult to get commercially have been most recently the responsibility of the Department of Energy's Nuclear Energy program. The President's FY09 Budget request proposed the transfer of the Isotope Production program to the Department of Energy's Office of Science in Nuclear Physics and to rename it the National Isotope Production and Application program (NIPA). The transfer has now taken place with the signing of the 2009 appropriations bill. In preparation for this, the Nuclear Science Advisory Committee (NSAC) was requested to establish a standing subcommittee, the NSAC Isotope Subcommittee (NSACI), to advise the DOE Office of Nuclear Physics. The request came in the form of two charges: one, on setting research priorities in the short term for the most compelling opportunities from the vast array of disciplines that develop and use isotopes and two, on making a long term strategic plan for the NIPA program. This is the final report to address charge 1. NSACI membership is comprised of experts from the diverse research communities, industry, production, and homeland security. NSACI discussed research opportunities divided into three areas: (1) medicine, pharmaceuticals, and biology, (2) physical sciences and engineering, and (3) national security and other applications. In each area, compelling research opportunities were considered and the subcommittee as a whole determined the final priorities for research opportunities as the foundations for the recommendations. While it was challenging to prioritize across disciplines, our order of recommendations reflect the compelling research prioritization along with consideration of time urgency for action as well as various geopolitical market issues. Common observations to all areas of research include the needs for domestic availability of crucial stable and radioactive isotopes and the education of the skilled workforce that will develop new advances using isotopes in the future. The six recommendations of NSACI reflect these concerns and the compelling research opportunities for potential new discoveries. The science case for each of the recommendations is elaborated in the respective chapters.

  8. Enzymatic Filter for Improved Separation of Output Signals in Enzyme Logic Systems towards 'Sense and Treat' Medicine

    SciTech Connect (OSTI)

    Mailloux, Shay; Zavalov, Oleksandr; Guz, Nataliia; Katz, Evgeny; Bocharova, Vera

    2014-01-01

    The major challenge for application of autonomous medical sensing systems is the noise produced by non-zero physiological concentrations of the sensed target. If the level of noise is high, then a real signal indicating abnormal changes in the physiological levels of the analytes might be hindered. Inevitably, this could lead to wrong diagnostics and treatment, and would have a negative impact on human health. Here, we report the realization of a filter system implemented to improve both the fidelity of sensing and accuracy of consequent drug release. A new filtering method was tested in the sensing system for the diagnosis of liver injury. This sensing system used the enzymes alanine transaminase (ALT) and aspartate transaminase (AST) as the inputs. Furthermore, the output of the sensing system was designed to trigger drug release, and therefore, the role of the filter in drug release was also investigated. The drug release system consists of beads with an iron - cross-linked alginate core coated with different numbers of layers of poly-L-lysine. Dissolution of the beads by the output signals of the sensing system in the presence and absence of the filter was monitored by release of encapsulated in the beads rhodamine - 6G dye mimicking release of a real drug. The obtained results offer a new view on the problem of noise reduction for systems intended to be part of sense and treat medical devices.

  9. Independent Oversight Review of Department of Energy Contractor Occupational Medicine Programs from June 1998 to December 1999

    Energy Savers [EERE]

    2009 | Department of Energy Office - December 2009 Independent Oversight Inspection, Savannah River Site Office - December 2009 December 2009 Inspection of Nuclear Safety at the Savannah River Site Office and the Tritium Program Facilities This report documents the results of an inspection of nuclear safety at several National Nuclear Security Administration (NNSA) facilities located at Department of Energy's (DOE) Savannah River Site. The inspection was performed during August and September

  10. Molecular medicine for the 21. century: A computational basis for design and critique of vaccines and therapeutics

    SciTech Connect (OSTI)

    Lapedes, A.; Myers, G.; Perelson, A.; Farber, R.; Tung, C.S.

    1997-08-01

    This is the final report of a three-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). The kissing-loop RNA motif is thought to modulate different steps in the retroviral life cycle. Using an RNA folding protocol developed under this project, the authors are studying the folding of the potential kissing-loop motif in HIV. Using only limited information on base-springs, and the constraints based on the connectivities, they are modeling the structure and the flexibility of this particular structural motif and have developed three predicted structures with low conformational energy. Following on the earlier work which analyzed correlated mutations in the V3 loop of HIV, they have developed an evolutionary model which incorporates non-independent mutations at different sequence positions in model sequences. This model takes into account the effects of the phylogenetic tree on the analysis of mutations, and shows a higher correspondence of correlated positions with structurally adjacent positions in the model than previous analyses. Additional research under this project has dealt with analyzing the dynamics of HIV in vivo. Using some simple models and patient data, they were able to establish for the first time some quantitative estimates of HIV dynamics in vivo.

  11. The Higgs: Not the Only Boson in Town | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The Higgs: Not the Only Boson in Town High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » 02.01.13 The Higgs: Not the Only Boson in Town Another boson has been found at the LHC that

  12. Bari Osmanov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Bari Osmanov University of Florida MiniBooNE experiment: recent results and future plans EPS HEP 2009 16-22 July, Krakow, Poland Bari Osmanov, University of Florida 1 of 18 on behalf of MiniBooNE collaboration EPS HEP 2009 16-22 July, Krakow, Poland Bari Osmanov, University of Florida 2 of 18 Outline * Booster neutrino beamline * MiniBooNE detector * Analysis overview * Recent results and future plans * Conclusion Booster neutrino beamline EPS HEP 2009 16-22 July, Krakow, Poland Bari Osmanov,

  13. New Particle Discovered May be the Long-Sought Higgs | U.S. DOE Office of

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Science (SC) New Particle Discovered May be the Long-Sought Higgs High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » 10.01.12 New Particle Discovered May be the Long-Sought Higgs

  14. A novel cantharidin analog N-Benzylcantharidinamide reduces the expression

    Office of Scientific and Technical Information (OSTI)

    of MMP-9 and invasive potentials of Hep3B via inhibiting cytosolic translocation of HuR (Journal Article) | SciTech Connect A novel cantharidin analog N-Benzylcantharidinamide reduces the expression of MMP-9 and invasive potentials of Hep3B via inhibiting cytosolic translocation of HuR Citation Details In-Document Search Title: A novel cantharidin analog N-Benzylcantharidinamide reduces the expression of MMP-9 and invasive potentials of Hep3B via inhibiting cytosolic translocation of HuR

  15. 2016 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    6 High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Featured Content 2016 2015 2014 2013 2012-2008 Reports Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » Featured Content 2016 Print Text Size: A A A FeedbackShare Page Four Flavor

  16. 2014 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    4 High Energy Physics (HEP) HEP Home About Research Facilities Science Highlights Benefits of HEP Funding Opportunities Advisory Committees Community Resources Contact Information High Energy Physics U.S. Department of Energy SC-25/Germantown Building 1000 Independence Ave., SW Washington, DC 20585 P: (301) 903-3624 F: (301) 903-2597 E: Email Us More Information » Science Highlights 2014 Print Text Size: A A A FeedbackShare Page Filter by Performer Or press Esc Key to close. close Select all

  17. Novel Materials and Devices for Solid-State Neutron Detection

    SciTech Connect (OSTI)

    Manginell, Ronald P.; Pfeifer, Kent B.

    2015-11-01

    There is a need in many fields, such as nuclear medicine, non-proliferation, energy exploration, national security, homeland security, nuclear energy, etc, for miniature, thermal neutron detectors. Until recently, thermal neutron detection has required physically large devices to provide sufficient neutron interaction and transduction signal. Miniaturization would allow broader use in the fields just mentioned and open up other applications potentially. Recent research shows promise in creating smaller neutron detectors through the combination of high-neutron-cross-section converter materials and solid-state devices. Yet, till recently it is difficult to measure low neutron fluxes by solidstate means given the need for optimized converter materials (purity, chemical composition and thickness) and a lack of designs capable of efficient transduction of the neutron conversion products (x-rays, electrons, gamma rays). Gadolinium-based semiconductor heterojunctions have detected electrons produced by Gd-neutron reactions but only at high neutron fluxes. One of the main limitations to this type of approach is the use of thin converter layers and the inability to utilize all the conversion products. In this LDRD we have optimized the converter material thickness and chemical composition to improve capture of conversion electrons and have detected thermal neutrons with high fidelity at low flux. We are also examining different semiconductor materials and converter materials to attempt to capture a greater percentage of the conversion electrons, both low and higher energy varieties. We have studied detector size and bias scaling, and cross-sensitivity to xrays and shown that we can detect low fluxes of thermal neutrons in less than 30 minutes with high selectivity by our approach. We are currently studying improvements in performance with direct placement of the Gd converter on the detector. The advancement of sensitive, miniature neutron detectors will have benefits in energy production, nonproliferation and medicine.

  18. Divisional Mentoring Program Contacts | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ES Sandy Davis sdavis@anl.gov EVS John Krummel** jkrummel@anl.gov HEP Maury Goodman maury.goodman@anl.gov LCF Scott Parker sparker@alcf.anl.gov MCS Tom Peterka...

  19. NUGEX 2014 Meeting Planning Subcommittee

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2014 Meeting Planning Subcommittee NUGEX 2014 Meeting Planning Subcommittee Members Frank Tsung, UCLA (HEP/FES) Gary Grest, Sandia (BES) Last edited: 2016-04-29 11:34:31

  20. NUGEX Queue Subcommittee

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Queue Subcommittee NUGEX Queue Subcommittee Members Anubhav Jain, Berkeley Lab (BES) Stephen Bailey, Berkeley Lab (HEP) Adrianne Middleton, NCAR (BER) Paul Kent, ORNL (BES) Last edited: 2016-04-29 11:34:44

  1. The Intermediate Higgs (Journal Article) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    The Intermediate Higgs Citation Details In-Document Search ... 890349 Report Number(s): SLAC-PUB-11111 hep-ph0504252 DOE Contract Number: AC02-76SF00515 Resource Type: Journal ...

  2. Bounding gauged skyrmion masses (Journal Article) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Bounding gauged skyrmion masses Citation Details In-Document ... OSTI Identifier: 1151557 Report Number(s): ANL-HEP-PR-04-89 DOE Contract Number: AC02-07CH11359 Resource Type: Journal ...

  3. TITLE AUTHORS SUBJECT SUBJECT RELATED DESCRIPTION PUBLISHER AVAILABILI...

    Office of Scientific and Technical Information (OSTI)

    HEP HEPEX HEPPH HEPTH In this lecture I review some of the perspectives on the Higgs boson discussed at the Higgs Hunting Worshop and discuss the short and long term...

  4. 4Li

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    vs relative E(3He, n), E(3He, p); deduced . 4Li deduced levels, . 1996ED02: 4He(p, nX), E 100, 200 MeV; measured inclusive (, En). 4Li deduced evidence for narrow...

  5. Status Report of the DPHEP Study Group: Towards a Global Effort for Sustainable Data Preservation in High Energy Physics

    SciTech Connect (OSTI)

    Akopov, Zaven; Amerio, Silvia; Asner, David; Avetisyan, Eduard; Barring, Olof; Beacham, James; Bernardi, Gregorio; Bethke, Siegfried; Boehnlein, Amber; Brooks, Travis; Browder, Thomas; Brun, Rene; Cartaro, Concetta; Cattaneo, Marco; Chen, Gang; Corney, David; Cranmer, Kyle; Culbertson, Ray; Dallmeier-Tiessen, Sunje; Denisov, Dmitri

    2013-03-27

    Data from high-energy physics (HEP) experiments are collected with significant financial and human effort and are mostly unique. An inter-experimental study group on HEP data preservation and long-term analysis was convened as a panel of the International Committee for Future Accelerators (ICFA). The group was formed by large collider-based experiments and investigated the technical and organisational aspects of HEP data preservation. An intermediate report was released in November 2009 addressing the general issues of data preservation in HEP. This paper includes and extends the intermediate report. It provides an analysis of the research case for data preservation and a detailed description of the various projects at experiment, laboratory and international levels. In addition, the paper provides a concrete proposal for an international organisation in charge of the data management and policies in high-energy physics.

  6. Close-Out Report of DOE Grant DE-FG02-91ER40682 for November 1, 2009 - April 30, 2013

    SciTech Connect (OSTI)

    Paulini, Manfred

    2013-07-20

    This document is the close-out report of Grant DE-FG02-91ER40682 from the Carnegie Mellon University (CMU) High-Energy Physics (HEP) Group to the U.S. Department of Energy (DOE).

  7. Even- and Odd-Parity Charmed Meson Masses in Heavy Hadron Chiral...

    Office of Scientific and Technical Information (OSTI)

    Authors: Thomas Mehen ; Roxanne Springer Publication Date: 2005-03-01 OSTI Identifier: 837971 Report Number(s): JLAB-THY-05-306; DOEER40150-3225; hep-ph0503134 TRN: US0501215 ...

  8. Implications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    * oscillations explained by small Lorentz violation * Osc. depends on direction of prop. * hep-ph 0406255, Kostelecky, Mewes H. Ray 7302004-p.713 Tests of NP : MiniBooNE *...

  9. Documents

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    | Date (low-high) | Date (high-low) | Source | Category HEP Exascale Requirements Review Case Study Template June 2, 2015 | Download File: CaseStudyTemplate-HEPrev.docx | docx |...

  10. Chiral Lagrangian with Heavy Quark-Diquark Symmetry (Journal...

    Office of Scientific and Technical Information (OSTI)

    OSTI Identifier: 862058 Report Number(s): JLAB-THY-05-452; DOEER40150-3669; hep-ph0511321 TRN: US0600111 DOE Contract Number: AC05-84ER40150 Resource Type: Journal...

  11. Chiral Lagrangian with Heavy Quark-Diquark Symmetry (Journal...

    Office of Scientific and Technical Information (OSTI)

    Publication Date: 2005-11-29 OSTI Identifier: 862058 Report Number(s): JLAB-THY-05-452; DOEER40150-3669; hep-ph0511321 TRN: US0600111 DOE Contract Number: AC05-84ER40150 ...

  12. Inflation Basics (Technical Report) | SciTech Connect

    Office of Scientific and Technical Information (OSTI)

    Citation Details In-Document Search Title: Inflation Basics Authors: Green, Dan 1 + Show ... Sponsoring Org: USDOE Office of Science (SC), High Energy Physics (HEP) (SC-25) Country of ...

  13. Present and Future Computing

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Important for DOE Energy Frontier Mission 2 * TH HEP is new ... & PDSF (studies based on usage for end of Sep 2012 - Nov ... framework (Sherpa), and a library for the computation of ...

  14. ANL Beams and Applications Seminar

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 Seminar Sponsers AAI ASD ATLAS HEP PHY ANL Beams and Applications Seminar The ANL Beam and Applications Seminar is...

  15. Workshop Presentations

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    12, 2009 | Author(s): Yukiko Sekine | Workshop Logistics November 12, 2009 | Author(s): Harvey Wasserman | DOE HEP Overview November 12, 2009 | Author(s): Amber Boehnlein | NERSC...

  16. Transcribed Media | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    Home Transcribed Media SC Home About ASCR HEP SBIR & STTR WDTS Contact Information Office of Science U.S. Department of Energy 1000 Independence Ave., SW Washington, DC 20585 P: ...

  17. PowerPoint Presentation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fermilab Users' Meeting Flux Prediction 9 Chris Polly, 2007 Fermilab Users' Meeting HARP collaboration, hep-ex0702024 Meson production at the target Kaons: Pions: MiniBooNE...

  18. PowerPoint Presentation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    W&C, 1 Aug 2008 Analysis Chain: Flux Prediction 8 Chris Polly, Fermilab W&C, 1 Aug 2008 HARP collaboration, hep-ex0702024 Meson production at the target Kaons: Pions: MiniBooNE...

  19. PowerPoint Presentation

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Boxes Signal Box 8 Chris Polly, NuFact 2007 Flux Prediction 9 Chris Polly, NuFact 2007 HARP collaboration, hep-ex0702024 Meson production at the target Kaons: Pions: MiniBooNE...

  20. BaBar Status and Prospects for CP Asymmetry Measurements: Sin...

    Office of Scientific and Technical Information (OSTI)

    Authors: Ganzhur, Sergey ; DSM, DAPNIA, Saclay Publication Date: 2007-04-06 OSTI Identifier: 901842 Report Number(s): SLAC-PUB-12443 hep-ph0703229; TRN: US200717%%88 DOE Contract ...