National Library of Energy BETA

Sample records for health pathways analysis

  1. Lurking Pathway Prediction And Pathway ODE Model Dynamic Analysis 

    E-Print Network [OSTI]

    Zhang, Rengjing

    2013-11-18

    Signaling pathway analysis is so important to study the causes of diseases and the treatment of drugs. Finding the lurking pathway from ligand to signature is a significant issue in studying the mechanism of how the cell response...

  2. Women’s Pathways to Mental Health in India

    E-Print Network [OSTI]

    Sood, Anubha

    2008-01-01

    Pathways to Mental Health in India: Comparing Psychiatry andindeed, doubts concerning India’s commitment to developmentwere popular and thriving in India was a matter of shame for

  3. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Boundary Analysis of Biological Pathways to Hydrogen Production Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production Report documenting the biological and...

  4. DYNAMIC INVARIANTS IN PROTEIN FOLDING PATHWAYS REVEALED BY TENSOR ANALYSIS

    E-Print Network [OSTI]

    Langmead, Christopher James

    DYNAMIC INVARIANTS IN PROTEIN FOLDING PATHWAYS REVEALED BY TENSOR ANALYSIS Arvind Ramanathan Lane a spatio-temporal analysis of protein folding pathways. We applied our method to folding simulations of how a protein folds into its functionally relevant conformations. Protein folding pathways span over

  5. Pathways to health in a deprived population: relationships between smoking, mental health & physical health 

    E-Print Network [OSTI]

    Kemp, Kim

    2011-06-30

    Introduction: Recently there has been increasing interest in understanding and addressing health inequalities and enhancing the well-being of the population as a whole through anticipatory care and better health care ...

  6. Epidemiology/Health Data Analysis - HPMC Occupational Health...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  7. CRITICAL RADIONUCLIDE AND PATHWAY ANALYSIS FOR THE SAVANNAH RIVER SITE

    SciTech Connect (OSTI)

    Jannik, T.

    2011-08-30

    This report is an update to the analysis, Assessment of SRS Radiological Liquid and Airborne Contaminants and Pathways, that was performed in 1997. An electronic version of this large original report is included in the attached CD to this report. During the operational history (1954 to the present) of the Savannah River Site (SRS), many different radionuclides have been released to the environment from the various production facilities. However, as will be shown by this updated radiological critical contaminant/critical pathway analysis, only a small number of the released radionuclides have been significant contributors to potential doses and risks to offsite people. The analysis covers radiological releases to the atmosphere and to surface waters, the principal media that carry contaminants offsite. These releases potentially result in exposure to offsite people. The groundwater monitoring performed at the site shows that an estimated 5 to 10% of SRS has been contaminated by radionuclides, no evidence exists from the extensive monitoring performed that groundwater contaminated with these constituents has migrated off the site (SRS 2011). Therefore, with the notable exception of radiological source terms originating from shallow surface water migration into site streams, onsite groundwater was not considered as a potential exposure pathway to offsite people. In addition, in response to the Department of Energy's (DOE) Order 435.1, several Performance Assessments (WSRC 2008; LWO 2009; SRR 2010; SRR 2011) and a Comprehensive SRS Composite Analysis (SRNO 2010) have recently been completed at SRS. The critical radionuclides and pathways identified in these extensive reports are discussed and, where applicable, included in this analysis.

  8. Using Bit-Vector Decision Procedures for Analysis of Protein Folding Pathways

    E-Print Network [OSTI]

    Langmead, Christopher James

    Using Bit-Vector Decision Procedures for Analysis of Protein Folding Pathways Christopher James-vector decision procedures for the analysis of protein folding pathways. We argue that the protein fold- ing by the different nature of the protein folding problem, we present a translation of the protein folding pathways

  9. Sample-Specific Cancer Pathway Analysis Using PARADIGM

    E-Print Network [OSTI]

    Benz, Stephen Charles

    2012-01-01

    of EGFR may promote oncogenesis and progression of solidmolecular mechanisms for oncogenesis. If common pathways canincluded they connect nd oncogenesis (20). concepts whose

  10. Human Health Risk & Environmental Analysis | Clean Energy | ORNL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Human Health Risk and Environmental Analysis SHARE Human Health Risk and Environmental Analysis Help decision makers assess emerging technologies and methods for identifying and...

  11. Stochastic Modeling and Analysis of Pathway Regulation and Dynamics 

    E-Print Network [OSTI]

    Zhao, Chen

    2012-07-16

    called masters or canalizing genes. Characterizing and detecting such genes are thus highly valuable for the treatment of cancer. Chapter II is devoted to this task, where we present a Bayesian framework to model pathway interactions and then study...

  12. Spatial Analysis of Health Risk Perception, Agenda and Position Papers

    E-Print Network [OSTI]

    Center for Spatially Integrated Social Science

    2003-01-01

    Risk perception. Ch 5 of Risk Analysis, Perception andworkplace methodology. Risk Analysis, 23, 311-324. Henwood,classic dilemmas in risk analysis. The perception of health

  13. Techno-Economic Boundary Analysis of Biological Pathways to Hydrogen...

    Broader source: Energy.gov (indexed) [DOE]

    Presentation by Brian James, Strategic Analysis Inc., at the Biological Hydrogen Production Workshop held September 24-25, 2013, at the National Renewable Energy Laboratory in...

  14. Employee Job Task Analysis (EJTA) - HPMC Occupational Health...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  15. Transcriptomic analysis in the developing zebrafish embryo after compound exposure: Individual gene expression and pathway regulation

    SciTech Connect (OSTI)

    Hermsen, Sanne A.B.; Pronk, Tessa E.; Brandhof, Evert-Jan van den; Ven, Leo T.M. van der; Piersma, Aldert H.

    2013-10-01

    The zebrafish embryotoxicity test is a promising alternative assay for developmental toxicity. Classically, morphological assessment of the embryos is applied to evaluate the effects of compound exposure. However, by applying differential gene expression analysis the sensitivity and predictability of the test may be increased. For defining gene expression signatures of developmental toxicity, we explored the possibility of using gene expression signatures of compound exposures based on commonly expressed individual genes as well as based on regulated gene pathways. Four developmental toxic compounds were tested in concentration-response design, caffeine, carbamazepine, retinoic acid and valproic acid, and two non-embryotoxic compounds, D-mannitol and saccharin, were included. With transcriptomic analyses we were able to identify commonly expressed genes, which were mostly development related, after exposure to the embryotoxicants. We also identified gene pathways regulated by the embryotoxicants, suggestive of their modes of action. Furthermore, whereas pathways may be regulated by all compounds, individual gene expression within these pathways can differ for each compound. Overall, the present study suggests that the use of individual gene expression signatures as well as pathway regulation may be useful starting points for defining gene biomarkers for predicting embryotoxicity. - Highlights: • The zebrafish embryotoxicity test in combination with transcriptomics was used. • We explored two approaches of defining gene biomarkers for developmental toxicity. • Four compounds in concentration-response design were tested. • We identified commonly expressed individual genes as well as regulated gene pathways. • Both approaches seem suitable starting points for defining gene biomarkers.

  16. Bridge mediated two-electron transfer reactions: Analysis of stepwise and concerted pathways

    E-Print Network [OSTI]

    Röder, Beate

    Bridge mediated two-electron transfer reactions: Analysis of stepwise and concerted pathways E. G-electron transfer TET mediated by a single regular bridge (B) is developed. The presence of different intermediate-exponential kinetics becomes possible. For the latter case the rate KTET is calculated, which describes the bridge

  17. The Thermodynamics and Kinetics of Protein Folding: A Lattice Model Analysis of Multiple Pathways with Intermediates

    E-Print Network [OSTI]

    Dinner, Aaron

    The Thermodynamics and Kinetics of Protein Folding: A Lattice Model Analysis of Multiple Pathways; In Final Form: May 5, 1999 The kinetics and thermodynamics of folding of a representative sequence of a 125-residue protein model subject to Monte Carlo dynamics on a simple cubic lattice were investigated

  18. NIH Portfolio Analysis on Climate Change and Health

    E-Print Network [OSTI]

    Madey, Gregory R.

    NIH Portfolio Analysis on Climate Change and Health Total studies that in some way relate to climate change 1,357 > Directly relate to climate change 7 > Examine the climate variables on health 85 response to climate change By David Taylor Climate change and its relationship to health research

  19. Principal Component Analysis for Fault Detection and Structure Health Monitoring

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Principal Component Analysis for Fault Detection and Structure Health Monitoring Nicolas Stoffels structure to ensure its health monitoring. The proposed approach is based on the PCA algorithm. Once PCA promptly and precisely [5]. FDI is also important in SHM (Structure Health Monitoring) because of aging

  20. Uncertainty and sensitivity analysis of food pathway results with the MACCS Reactor Accident Consequence Model

    SciTech Connect (OSTI)

    Helton, J.C.; Johnson, J.D.; Rollstin, J.A.; Shiver, A.W.; Sprung, J.L.

    1995-01-01

    Uncertainty and sensitivity analysis techniques based on Latin hypercube sampling, partial correlation analysis and stepwise regression analysis are used in an investigation with the MACCS model of the food pathways associated with a severe accident at a nuclear power station. The primary purpose of this study is to provide guidance on the variables to be considered in future review work to reduce the uncertainty in the important variables used in the calculation of reactor accident consequences. The effects of 87 imprecisely-known input variables on the following reactor accident consequences are studied: crop growing season dose, crop long-term dose, milk growing season dose, total food pathways dose, total ingestion pathways dose, total long-term pathways dose, area dependent cost, crop disposal cost, milk disposal cost, condemnation area, crop disposal area and milk disposal area. When the predicted variables are considered collectively, the following input variables were found to be the dominant contributors to uncertainty: fraction of cesium deposition on grain fields that is retained on plant surfaces and transferred directly to grain, maximum allowable ground concentrations of Cs-137 and Sr-90 for production of crops, ground concentrations of Cs-134, Cs-137 and I-131 at which the disposal of milk will be initiated due to accidents that occur during the growing season, ground concentrations of Cs-134, I-131 and Sr-90 at which the disposal of crops will be initiated due to accidents that occur during the growing season, rate of depletion of Cs-137 and Sr-90 from the root zone, transfer of Sr-90 from soil to legumes, transfer of Cs-137 from soil to pasture, transfer of cesium from animal feed to meat, and the transfer of cesium, iodine and strontium from animal feed to milk.

  1. An In-depth Analysis of Iron and Pathogenicity Regulatory Pathways in Pseudomonas syringae pv. syringae B728a 

    E-Print Network [OSTI]

    Greenwald, Jessica Williams

    2012-10-19

    -DEPTH ANALYSIS OF IRON AND PATHOGENICITY REGULATORY PATHWAYS IN Pseudomonas syringae pv. syringae B728A A Dissertation by JESSICA WILLIAMS GREENWALD Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment... of the requirements for the degree of DOCTOR OF PHILOSOPHY August 2011 Major Subject: Plant Pathology An In-Depth Analysis of Iron and Pathogenicity Regulatory Pathways in Pseudomonas...

  2. EVMS Training Snippet: 5.3 PARSII Analysis: Schedule Health Assessment...

    Energy Savers [EERE]

    5.3 PARSII Analysis: Schedule Health Assessment EVMS Training Snippet: 5.3 PARSII Analysis: Schedule Health Assessment This EVMS Training Snippet, sponsored by the Office of...

  3. Well-to-wheels analysis of fast pyrolysis pathways with the GREET model.

    SciTech Connect (OSTI)

    Han, J.; Elgowainy, A.; Palou-Rivera, I.; Dunn, J.B.; Wang, M.Q.

    2011-12-01

    The pyrolysis of biomass can help produce liquid transportation fuels with properties similar to those of petroleum gasoline and diesel fuel. Argonne National Laboratory conducted a life-cycle (i.e., well-to-wheels [WTW]) analysis of various pyrolysis pathways by expanding and employing the Greenhouse Gases, Regulated Emissions, and Energy Use in Transportation (GREET) model. The WTW energy use and greenhouse gas (GHG) emissions from the pyrolysis pathways were compared with those from the baseline petroleum gasoline and diesel pathways. Various pyrolysis pathway scenarios with a wide variety of possible hydrogen sources, liquid fuel yields, and co-product application and treatment methods were considered. At one extreme, when hydrogen is produced from natural gas and when bio-char is used for process energy needs, the pyrolysis-based liquid fuel yield is high (32% of the dry mass of biomass input). The reductions in WTW fossil energy use and GHG emissions relative to those that occur when baseline petroleum fuels are used, however, is modest, at 50% and 51%, respectively, on a per unit of fuel energy basis. At the other extreme, when hydrogen is produced internally via reforming of pyrolysis oil and when bio-char is sequestered in soil applications, the pyrolysis-based liquid fuel yield is low (15% of the dry mass of biomass input), but the reductions in WTW fossil energy use and GHG emissions are large, at 79% and 96%, respectively, relative to those that occur when baseline petroleum fuels are used. The petroleum energy use in all scenarios was restricted to biomass collection and transportation activities, which resulted in a reduction in WTW petroleum energy use of 92-95% relative to that found when baseline petroleum fuels are used. Internal hydrogen production (i.e., via reforming of pyrolysis oil) significantly reduces fossil fuel use and GHG emissions because the hydrogen from fuel gas or pyrolysis oil (renewable sources) displaces that from fossil fuel natural gas and the amount of fossil natural gas used for hydrogen production is reduced; however, internal hydrogen production also reduces the potential petroleum energy savings (per unit of biomass input basis) because the fuel yield declines dramatically. Typically, a process that has a greater liquid fuel yield results in larger petroleum savings per unit of biomass input but a smaller reduction in life-cycle GHG emissions. Sequestration of the large amount of bio-char co-product (e.g., in soil applications) provides a significant carbon dioxide credit, while electricity generation from bio-char combustion provides a large energy credit. The WTW energy and GHG emissions benefits observed when a pyrolysis oil refinery was integrated with a pyrolysis reactor were small when compared with those that occur when pyrolysis oil is distributed to a distant refinery, since the activities associated with transporting the oil between the pyrolysis reactors and refineries have a smaller energy and emissions footprint than do other activities in the pyrolysis pathway.

  4. Evaluation of the Pathways for Students into Health Professions: The Training of Under-Represented Minority Students to Pursue Maternal and Child Health Professions

    E-Print Network [OSTI]

    Guerrero, AD; Holmes, FJ; Inkelas, M; Perez, VH; Verdugo, B; Kuo, AA

    2015-01-01

    programs in the health professions, Part 1: Pre- servingmaternal and child health professions. A baseline survey onfor Students into Health Professions: The Training of Under-

  5. Molasses for ethanol: the economic and environmental impacts of a new pathway for the lifecycle greenhouse gas analysis of sugarcane ethanol

    E-Print Network [OSTI]

    Kammen, Daniel M.

    Molasses for ethanol: the economic and environmental impacts of a new pathway for the lifecycle greenhouse gas analysis of sugarcane ethanol This article has been downloaded from IOPscience. Please scroll for ethanol: the economic and environmental impacts of a new pathway for the lifecycle greenhouse gas analysis

  6. Pathway confirmation and flux analysis of central metabolic pathways in Desulfovibrio vulgaris Hildenborough using gas chromatography-mass spectrometry and fourier transform-ion cyclotron resonance mass spectrometry

    E-Print Network [OSTI]

    Tang, Yinjie

    2010-01-01

    the second flow into gluconeogenesis and the PP pathway; andBiomass (Phe, Tyr, Trp) Gluconeogenesis Biomass (Ser, Gly,

  7. ALL-PATHWAYS DOSE ANALYSIS FOR THE PORTSMOUTH ON-SITE WASTE DISPOSAL FACILITY

    SciTech Connect (OSTI)

    Smith, F.; Phifer, M.

    2014-04-10

    A Portsmouth On-Site Waste Disposal Facility (OSWDF) All-Pathways analysis has been conducted that considers the radiological impacts to a resident farmer. It is assumed that the resident farmer utilizes a farm pond contaminated by the OSWDF to irrigate a garden and pasture and water livestock from which food for the resident farmer is obtained, and that the farmer utilizes groundwater from the Berea sandstone aquifer for domestic purposes (i.e. drinking water and showering). As described by FBP 2014b the Hydrologic Evaluation of Landfill Performance (HELP) model (Schroeder et al. 1994) and the Surface Transport Over Multiple Phases (STOMP) model (White and Oostrom 2000, 2006) were used to model the flow and transport from the OSWDF to the Points of Assessment (POAs) associated with the 680-ft elevation sandstone layer (680 SSL) and the Berea sandstone aquifer. From this modeling the activity concentrations radionuclides were projected over time at the POAs. The activity concentrations were utilized as input to a GoldSimTM (GTG 2010) dose model, described herein, in order to project the dose to a resident farmer over time. A base case and five sensitivity cases were analyzed. The sensitivity cases included an evaluation of the impacts of using a conservative inventory, an uncased well to the Berea sandstone aquifer, a low waste zone uranium distribution coefficient (Kd), different transfer factors, and reference person exposure parameters (i.e. at 95 percentile). The maximum base case dose within the 1,000 year assessment period was projected to be 1.5E-14 mrem/yr, and the maximum base case dose at any time less than 10,000 years was projected to be 0.002 mrem/yr. The maximum projected dose of any sensitivity case was approximately 2.6 mrem/yr associated with the use of an uncased well to the Berea sandstone aquifer. This sensitivity case is considered very unlikely because it assumes leakage from the location of greatest concentration in the 680 SSL in to the Berea sandstone aquiver over time and does not conform to standard private water well construction practices. The bottom-line is that all predicted doses from the base case and five sensitivity cases fall well below the DOE all-pathways 25 mrem/yr Performance Objective.

  8. Sensor data analysis and information extraction for structural health monitoring

    E-Print Network [OSTI]

    Yan, Linjun

    2006-01-01

    Workshop on Structural Health Monitoring, StanfordA Review of Structural Health Monitoring Literature: 1996-workshop on structural Health Monitoring: Structural Health

  9. Lifecycle Analysis of Air Quality Impacts of Hydrogen and Gasoline Transportation Fuel Pathways

    E-Print Network [OSTI]

    Wang, Guihua

    2008-01-01

    of natural gas-to-hydrogen pathways on urban air quality ofnatural gas extraction and pipeline transport on air qualityas natural gas extraction and oil refining) on air quality

  10. A Meta-Analysis of Motivational Interviewing Interventions for Pediatric Health Behavior Change

    E-Print Network [OSTI]

    Gayes, Laurie

    2013-08-31

    concerns with a range of clients age groups. The following meta-analysis analyzed MI's effectiveness in eliciting behavior change in pediatric health domains. Thirty-seven empirical studies were included in this meta-analysis, encompassing eight health...

  11. SPECIAL ANALYSIS AIR PATHWAY MODELING OF E-AREA LOW-LEVEL WASTE FACILITY

    SciTech Connect (OSTI)

    Hiergesell, R.; Taylor, G.

    2011-08-30

    This Special Analysis (SA) was initiated to address a concern expressed by the Department of Energy's Low Level Waste Disposal Facility Federal Review Group (LFRG) Review Team during their review of the 2008 E-Area Performance Assessment (PA) (WSRC, 2008). Their concern was the potential for overlapping of atmospheric plumes, emanating from the soil surface above SRS LLW disposal facilities within the E-Area, to contribute to the dose received by a member of the public during the Institutional Control (IC) period. The implication of this concern was that the dose to the maximally-exposed individual (MEI) located at the SRS boundary might be underestimated during this time interval. To address this concern a re-analysis of the atmospheric pathway releases from E-Area was required. In the process of developing a new atmospheric release model (ARM) capable of addressing the LFRG plume overlap concern, it became obvious that new and better atmospheric pathway disposal limits should be developed for each of the E-Area disposal facilities using the new ARM. The scope of the SA was therefore expanded to include the generation of these new limits. The initial work conducted in this SA was to develop a new ARM using the GoldSim{reg_sign} program (GTG, 2009). The model simulates the subsurface vapor diffusion of volatile radionuclides as they release from E-Area disposal facility waste zones and migrate to the land surface. In the process of this work, many new features, including several new physical and chemical transport mechanisms, were incorporated into the model. One of the most important improvements was to incorporate a mechanism to partition volatile contaminants across the water-air interface within the partially saturated pore space of the engineered and natural materials through which vapor phase transport occurs. A second mechanism that was equally important was to incorporate a maximum concentration of 1.9E-07 Ci/m{sup 3} of {sup 14}CO{sub 2} in the air-filled pores of cementitious materials. The ARM also combines the individual transport models constructed for each E-Area disposal facility into a single model, and was ultimately used to analyze the LFRG concern regarding the potential for atmospheric plume overlap at the SRS boundary during the IC period. To evaluate the plume overlap issue, a conservative approach was adopted whereby the MEI at the SRS boundary was exposed to the releases from all E-Area disposal facilities simultaneously. This is equivalent to a 100% overlap of all atmospheric plumes emanating from E-Area. Should the dose received from this level of atmospheric plume overlap still fall below the permissible exposure level of 10 mrem/yr, then the LFRG concern would be alleviated. The structuring of the ARM enables this evaluation to be easily performed. During the IC period, the peak of the 'total plume overlap dose' was computed to be 1.9E-05 mrem/yr, which is five orders of magnitude lower than the 10 mrem/yr PA performance objective for the atmospheric release pathway. The main conclusion of this study is that for atmospheric releases from the E-Area disposal facilities, plume overlap does not cause the total dose to the MEI at the SRS boundary during the IC to exceed the Performance Assessment (PA) performance objective. Additionally, the potential for plume overlap was assessed in the post-Institutional Control period. Atmospheric plume overlap is less likely to occur during this period but conceivably could occur if the prevailing wind direction shifted so as to pass directly over all EArea disposal facilities and transport airborne radionuclides to the MEI at the 100 m point of compliance (POC). This concern was also demonstrated of little concern, as the maximum plume overlap dose was found to be 1.45E+00 mrem/yr (or {approx}15% of the performance measure) during this period and under these unlikely conditions.

  12. Pathway and Resource Overview (Presentation)

    SciTech Connect (OSTI)

    Ruth, M. F.

    2009-11-16

    This presentation provides information about hydrogen pathway analysis, which is analysis of the total levelized cost (including return on investment). Well-to-wheels (WTW) energy use, and WTW emissions for hydrogen production, delivery, and distribution pathways.

  13. Bayesian Analysis of the Phase II IASCASCE Structural Health Monitoring Experimental Benchmark Data

    E-Print Network [OSTI]

    Heaton, Thomas H.

    Bayesian Analysis of the Phase II IASC­ASCE Structural Health Monitoring Experimental Benchmark­ASCE Task Group on Structural Health Monitoring. This study involves damage detection and assessment; Identification; Bench marks; Structural analysis; Modal analysis. Introduction Structural health monitoring (SHM

  14. Lifecycle Analysis of Air Quality Impacts of Hydrogen and Gasoline Transportation Fuel Pathways

    E-Print Network [OSTI]

    Wang, Guihua

    2008-01-01

    by Ozone Air Pollution from Motor Vehicles. University ofHealth Effects of Motor-Vehicle Air Pollution. University ofby ozone air pollution from motor vehicles. Journal of

  15. Pathway and Resource Overview

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    using the Macro-System Model (MSM) * Resource and pathway analysis using the Hydrogen Demand and Resource Analysis Tool (HyDRA) * Status of water-electrolysis technology 2...

  16. Waste-to-wheel analysis of anaerobic-digestion-based renewable natural gas pathways with the GREET model.

    SciTech Connect (OSTI)

    Han, J.; Mintz, M.; Wang, M.

    2011-12-14

    In 2009, manure management accounted for 2,356 Gg or 107 billion standard cubic ft of methane (CH{sub 4}) emissions in the United States, equivalent to 0.5% of U.S. natural gas (NG) consumption. Owing to the high global warming potential of methane, capturing and utilizing this methane source could reduce greenhouse gas (GHG) emissions. The extent of that reduction depends on several factors - most notably, how much of this manure-based methane can be captured, how much GHG is produced in the course of converting it to vehicular fuel, and how much GHG was produced by the fossil fuel it might displace. A life-cycle analysis was conducted to quantify these factors and, in so doing, assess the impact of converting methane from animal manure into renewable NG (RNG) and utilizing the gas in vehicles. Several manure-based RNG pathways were characterized in the GREET (Greenhouse gases, Regulated Emissions, and Energy use in Transportation) model, and their fuel-cycle energy use and GHG emissions were compared to petroleum-based pathways as well as to conventional fossil NG pathways. Results show that despite increased total energy use, both fossil fuel use and GHG emissions decline for most RNG pathways as compared with fossil NG and petroleum. However, GHG emissions for RNG pathways are highly dependent on the specifics of the reference case, as well as on the process energy emissions and methane conversion factors assumed for the RNG pathways. The most critical factors are the share of flared controllable CH{sub 4} and the quantity of CH{sub 4} lost during NG extraction in the reference case, the magnitude of N{sub 2}O lost in the anaerobic digestion (AD) process and in AD residue, and the amount of carbon sequestered in AD residue. In many cases, data for these parameters are limited and uncertain. Therefore, more research is needed to gain a better understanding of the range and magnitude of environmental benefits from converting animal manure to RNG via AD.

  17. Model-based Security Analysis of the German Health Card Architecture

    E-Print Network [OSTI]

    Jurjens, Jan

    information systems, security, German Health Card. 1 #12;1 Introduction The use of health-care information information security that are particularly significant for health-care systems, due both to the inherent these risks and enable secure health-care information systems, the security analysis has to be embedded

  18. Lifecycle Analysis of Air Quality Impacts of Hydrogen and Gasoline Transportation Fuel Pathways

    E-Print Network [OSTI]

    Wang, Guihua

    2008-01-01

    ITS-RR-08-28 Lifecycle Analysis of Air Quality Impacts ofEngineering Lifecycle Analysis of Air Quality Impacts ofa regional lifecycle analysis of air quality impacts is

  19. Comparative genomic analysis of nine Sphingobium strains: Insights into their evolution and hexachlorocyclohexane (HCH) degradation pathways

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Verma, Helianthous; Kumar, Roshan; Oldach, Phoebe; Sangwan, Naseer; Khurana, Jitendra P.; Gilbert, Jack A.; Lal, Rup

    2014-11-23

    Background: Sphingobium spp. are efficient degraders of a wide range of chlorinated and aromatic hydrocarbons. In particular, strains which harbour the lin pathway genes mediating the degradation of hexachlorocyclohexane (HCH) isomers are of interest due to the widespread persistence of this contaminant. Here, we examined the evolution and diversification of the lin pathway under the selective pressure of HCH, by comparing the draft genomes of six newly-sequenced Sphingobium spp. (strains LL03, DS20, IP26, HDIPO4, P25 and RL3) isolated from HCH dumpsites, with three existing genomes (S. indicum B90A, S. japonicum UT26S and Sphingobium sp. SYK6). Results: Efficient HCH degraders phylogeneticallymore »clustered in a closely related group comprising of UT26S, B90A, HDIPO4 and IP26, where HDIPO4 and IP26 were classified as subspecies with ANI value >98%. Less than 10% of the total gene content was shared among all nine strains, but among the eight HCH-associated strains, that is all except SYK6, the shared gene content jumped to nearly 25%. Genes associated with nitrogen stress response and two-component systems were found to be enriched. The strains also housed many xenobiotic degradation pathways other than HCH, despite the absence of these xenobiotics from isolation sources. In addition, these strains, although non-motile, but posses flagellar assembly genes. While strains HDIPO4 and IP26 contained the complete set of lin genes, DS20 was entirely devoid of lin genes (except linKLMN) whereas, LL03, P25 and RL3 were identified as lin deficient strains, as they housed incomplete lin pathways. Further, in HDIPO4, linA was found as a hybrid of two natural variants i.e., linA1 and linA2 known for their different enantioselectivity. In conclusion, the bacteria isolated from HCH dumpsites provide a natural testing ground to study variations in the lin system and their effects on degradation efficacy. Further, the diversity in the lin gene sequences and copy number, their arrangement with respect to IS6100 and evidence for potential plasmid content elucidate possible evolutionary acquisition mechanisms for this pathway. This study further opens the horizon for selection of bacterial strains for inclusion in an HCH bioremediation consortium and suggests that HDIPO4, IP26 and B90A would be appropriate candidates for inclusion.« less

  20. Lifecycle Analysis of Air Quality Impacts of Hydrogen and Gasoline Transportation Fuel Pathways

    E-Print Network [OSTI]

    Wang, Guihua

    2008-01-01

    2004. Fuel economy of hydrogen fuel cell vehicles. Journal2005. Switching to a U.S. hydrogen fuel cell vehicle fleet:Improving Health with Hydrogen Fuel-Cell Vehicles. SCIENCE

  1. Modern Information Technologies in Environmental Health Surveillance: an Overview and Analysis

    E-Print Network [OSTI]

    1 Modern Information Technologies in Environmental Health Surveillance: an Overview and Analysis of numerous new information technologies (IT) that are having significant impacts on society. Many authors Information Technology For Environmental Health Surveillance World Wide Web The massive penetration

  2. Analysis of Metabolic Pathways and Fluxes in a Newly Discovered Thermophilic and Ethanol-Tolerant Geobacillus Strain

    E-Print Network [OSTI]

    Tang, Yinjie J.

    2009-01-01

    explore its metabolism for bioethanol or other bioprocessthe metabolic pathways for bioethanol production as well as

  3. Improved Protein Arrays for Quantitative Systems Analysis of the Dynamics of Signaling Pathway Interactions

    SciTech Connect (OSTI)

    YANG, CHIN-RANG

    2013-12-11

    Astronauts and workers in nuclear plants who repeatedly exposed to low doses of ionizing radiation (IR, <10 cGy) are likely to incur specific changes in signal transduction and gene expression in various tissues of their body. Remarkable advances in high throughput genomics and proteomics technologies enable researchers to broaden their focus from examining single gene/protein kinetics to better understanding global gene/protein expression profiling and biological pathway analyses, namely Systems Biology. An ultimate goal of systems biology is to develop dynamic mathematical models of interacting biological systems capable of simulating living systems in a computer. This Glue Grant is to complement Dr. Boothman’s existing DOE grant (No. DE-FG02-06ER64186) entitled “The IGF1/IGF-1R-MAPK-Secretory Clusterin (sCLU) Pathway: Mediator of a Low Dose IR-Inducible Bystander Effect” to develop sensitive and quantitative proteomic technology that suitable for low dose radiobiology researches. An improved version of quantitative protein array platform utilizing linear Quantum dot signaling for systematically measuring protein levels and phosphorylation states for systems biology modeling is presented. The signals are amplified by a confocal laser Quantum dot scanner resulting in ~1000-fold more sensitivity than traditional Western blots and show the good linearity that is impossible for the signals of HRP-amplification. Therefore this improved protein array technology is suitable to detect weak responses of low dose radiation. Software is developed to facilitate the quantitative readout of signaling network activities. Kinetics of EGFRvIII mutant signaling was analyzed to quantify cross-talks between EGFR and other signaling pathways.

  4. Integrated analysis of breast cancer cell lines reveals unique signaling pathways

    SciTech Connect (OSTI)

    Heiser, Laura M.; Wang, Nicholas J.; Talcott, Carolyn L.; Laderoute, Keith R.; Knapp, Merrill; Guan, Yinghui; Hu, Zhi; Ziyad, Safiyyah; Weber, Barbara L.; Laquerre, Sylvie; Jackson, Jeffrey R.; Wooster, Richard F.; Kuo, Wen-Lin; Gray, Joe W.; Spellman, Paul T.

    2009-03-31

    Cancer is a heterogeneous disease resulting from the accumulation of genetic defects that negatively impact control of cell division, motility, adhesion and apoptosis. Deregulation in signaling along the EGFR-MAPK pathway is common in breast cancer, though the manner in which deregulation occurs varies between both individuals and cancer subtypes. We were interested in identifying subnetworks within the EGFR-MAPK pathway that are similarly deregulated across subsets of breast cancers. To that end, we mapped genomic, transcriptional and proteomic profiles for 30 breast cancer cell lines onto a curated Pathway Logic symbolic systems model of EGFR-MEK signaling. This model was comprised of 539 molecular states and 396 rules governing signaling between active states. We analyzed these models and identified several subtype specific subnetworks, including one that suggested PAK1 is particularly important in regulating the MAPK cascade when it is over-expressed. We hypothesized that PAK1 overexpressing cell lines would have increased sensitivity to MEK inhibitors. We tested this experimentally by measuring quantitative responses of 20 breast cancer cell lines to three MEK inhibitors. We found that PAK1 over-expressing luminal breast cancer cell lines are significantly more sensitive to MEK inhibition as compared to those that express PAK1 at low levels. This indicates that PAK1 over-expression may be a useful clinical marker to identify patient populations that may be sensitive to MEK inhibitors. All together, our results support the utility of symbolic system biology models for identification of therapeutic approaches that will be effective against breast cancer subsets.

  5. Comprehensive analysis of metabolic pathways through the combined use of multiple isotopic tracers

    E-Print Network [OSTI]

    Antoniewicz, Maciek Robert

    2006-01-01

    Metabolic Flux Analysis (MFA) has emerged as a tool of great significance for metabolic engineering and the analysis of human metabolic diseases. An important limitation of MFA, as carried out via stable isotope labeling ...

  6. Session on computation in biological pathways

    SciTech Connect (OSTI)

    Karp, P.D.; Riley, M.

    1996-12-31

    The papers in this session focus on the development of pathway databases and computational tools for pathway analysis. The discussion involves existing databases of sequenced genomes, as well as techniques for studying regulatory pathways.

  7. Recursive Pathways to Marginal Likelihood Estimation with Prior-Sensitivity Analysis

    E-Print Network [OSTI]

    Cameron, Ewan

    2013-01-01

    We investigate the utility to contemporary Bayesian studies of recursive, Gauss-Seidel-type pathways to marginal likelihood estimation characterized by reverse logistic regression and the density of states. Through a pair of illustrative, numerical examples (including mixture modeling of the well-known 'galaxy dataset') we highlight both the remarkable diversity of bridging schemes amenable to recursive normalization and the notable efficiency of the resulting pseudo-mixture densities for gauging prior-sensitivity in the model selection context. Our key theoretical contributions show the connection between the nested sampling identity and the density of states. Further, we introduce a novel heuristic ('thermodynamic integration via importance sampling') for qualifying the role of the bridging sequence in marginal likelihood estimation. An efficient pseudo-mixture density scheme for harnessing the information content of otherwise discarded draws in ellipse-based nested sampling is also introduced.

  8. Analysis of Senate Bill 92: Health Care Reform

    E-Print Network [OSTI]

    2009-01-01

    CJ. Effects of State Reforms on Health Insurance Coverage ofMorrisey MA. Small Group Reform and Insurance Provision byInterest Groups and Health Reform: Lessons from California.

  9. Analysis of Senate Bill 92: Health Care Reform

    E-Print Network [OSTI]

    2009-01-01

    acupuncture, infertility treatments, jawbone or associatedacupuncture, infertility treatments, jawbone or associatedpublic health scope Infertility treatments 15.1% of married

  10. Air pathway analysis for cleanup at the chemical plant area of the Weldon Spring site

    SciTech Connect (OSTI)

    Chang, Y.S.

    1994-01-01

    The Weldon Spring site is a mixed waste site located in St. Charles County, Missouri. Cleanup of the site is in the planning and design stage, and various engineering activities were considered for remedial action, including excavating soils, dredging sludge, treating various contaminated media in temporary facilities, transporting and staging supplies and contaminated material, and placing waste in an engineered disposal cell. Both contaminated and uncontaminated emissions from these activities were evaluated to assess air quality impacts and potential health effects for workers and the general public during the cleanup period. A site-specific air quality modeling approach was developed to address several complex issues, such as a variety of emission sources, an array of source/receptor configurations, and complicated sequencing/scheduling. This approach can be readily adapted to reflect changes in the expected activities as engineering plans are finalized.

  11. Protein Folding Trajectories Analysis: Summarization, Event Detection and Consensus Partial Folding Pathway

    E-Print Network [OSTI]

    Yang, Hui

    Protein Folding Trajectories Analysis: Summarization, Event Detection and Consensus Partial Folding in protein folding trajectories. We pro- pose an approach that employs the simplicity of contact maps and po- tentially cure diseases caused by misfolding. The protein folding problem is therefore one

  12. Fuel Pathways Integration Tech Team

    Office of Energy Efficiency and Renewable Energy (EERE)

    Presentation on Fuel Pathways Integration Tech Team to the DOE Systems Analysis Workshop held in Washington, D.C. July 28-29, 2004.

  13. Analysis of Assembly Bill 2281: High Deductible Health Care Coverage

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2006-01-01

    Jr. , Manning WG, et al. Prepaid group practice effects onratio of the amount of prepaid or periodic charge revenueand cholesterol screening Prepaid health plans associated

  14. Preliminary analysis of important site-specific dose assessment parameters and exposure pathways applicable to a groundwater release scenario at Yucca Mountain

    SciTech Connect (OSTI)

    Laplante, P.A. [Center for Nuclear Waste Regulatory Analyses, Rockville, MD (United States); Maheras, S.J. [Maheras (S.J.), Idaho Falls, ID (United States); Jarzemba, M.S. [Center for Nuclear Waste Regulatory Analyses, San Antonio, TX (United States)

    1996-08-01

    To develop capabilities for compliance determination, the Nuclear Regulatory Commission (NRC) conducts total system performance assessment (TSPA) for the proposed repository at Yucca Mountain (YM) in an iterative manner. Because the new Environmental Protection Agency (EPA) standard for YM may set a dose or risk limit, an auxiliary study was conducted to develop estimates of site-specific dose assessment parameters for future TSPAS. YM site-relevant data was obtained for irrigation, agriculture, resuspension, crop interception, and soil. A Monte Carlo based importance analysis was used to identify predominant parameters for the groundwater pathway. In this analysis, the GENII-S code generated individual annual total effective dose equivalents (TEDEs) for 20 nuclides and 43 sampled parameters based upon unit groundwater concentrations. Scatter plots and correlation results indicate the crop interception fraction, food transfer factors, consumption rates, and irrigation rate are correlated with TEDEs for specific nuclides. Influential parameter groups correspond to expected pathway readily to plants, such as {sup 99}Tc, indicate crop ingestion pathway parameters are most highly correlated with the TEDE, and those that transfer to milk ({sup 59}Ni) or beef ({sup 79}Se, {sup 129}I, {sup 135}Cs, {sup 137}Cs) show predominant correlations with animal product ingestion pathway parameters. Such relationships provide useful insight to important parameters and exposure pathways applicable to doses from specific nuclides.

  15. Flux analysis of central metabolic pathways in the Fe (III)-reducing organism Geobacter metallireducens via 13C isotopic labeling

    E-Print Network [OSTI]

    Tang, Yinjie J.; Chakraborty, Romy; Martin, Hector Garcia; Chu, Jeannie; Hazen, Terry C.; Keasling, Jay D.

    2007-01-01

    His) Biomass (Phe, Tyr, Trp) Gluconeogenesis PP pathway PEPmalic enzyme were absent. Gluconeogenesis and the pentoseGS-15 include gluconeogenesis, the TCA cycle, and the

  16. National Dialogue on Career Pathways

    Broader source: Energy.gov [DOE]

    On Tuesday, September 23, 2014, the U.S. Departments of Labor, Education and Health and Human Services will host a National Dialogue on Career Pathways.  Federal agency leaders from each Department...

  17. Analysis of Senate Bill 92: Health Care Reform

    E-Print Network [OSTI]

    2009-01-01

    be summarized briefly (e.g. , off-label use of prescriptionfor all drugs that are used off-label, not on health plans’drugs: coverage of “off-label” use Prescription drugs:

  18. Postgraduate Certificate in Risk Analysis in Health and Food Safety: Programme Specification 1. Awarding institution The Royal Veterinary College

    E-Print Network [OSTI]

    Daley, Monica A.

    Postgraduate Certificate in Risk Analysis in Health and Food Safety: Programme Specification 1 Title Postgraduate Certificate in Risk Analysis in Health and Food Safety 6. Date of First Intake March understanding of the principles and methods of risk analysis in health and food safety, and develop skills

  19. Perceived challenges to public health in Central and Eastern Europe: a qualitative analysis

    E-Print Network [OSTI]

    Müller-Nordhorn, Jacqueline; Holmberg, Christine; Dokova, Klara G.; Milevska-Kostova, Neda; Chicin, Gratiana; Ulrichs, Timo; Rechel, Bernd; Willich, Stefan N.; Powles, John; Tinnemann, Peter

    2012-04-26

    Open Access ublic health in Central litative analysis G Dokova3, Neda Milevska-Kostova4, Gratiana Chicin5, s8 and Peter Tinnemann1 between Central and Eastern Europe compared to tors are amenable to public health interventions. Thed Central Ltd...

  20. Pathway confirmation and flux analysis of central metabolicpathways in Desulfovibrio vulgaris Hildenborough using gaschromatography-mass spectrometry and fourier transform-ion cyclotronresonance mass spectrometry

    SciTech Connect (OSTI)

    Tang, Yinjie; Pingitore, Francesco; Mukhopadhyay, Aindrila; Phan,Richard; Hazen, Terry C.; Keasling, Jay D.

    2006-07-11

    It has been proposed that during growth under anaerobic oroxygen-limited conditions Shewanella oneidensis MR-1 uses theserine-isocitrate lyase pathway common to many methylotrophic anaerobes,in which formaldehyde produced from pyruvate is condensed with glycine toform serine. The serine is then transformed through hydroxypyruvate andglycerate to enter central metabolism at phosphoglycerate. To examine itsuse of the serine-isocitrate lyase pathway under anaerobic conditions, wegrew S. oneidensis MR-1 on [1-13C]lactate as the sole carbon source witheither trimethylamine N-oxide (TMAO) or fumarate as an electron acceptor.Analysis of cellular metabolites indicates that a large percentage(>75 percent) of lactate was partially oxidized to either acetate orpyruvate. The 13C isotope distributions in amino acids and other keymetabolites indicate that, under anaerobic conditions, a complete serinepathway is not present, and lactate is oxidized via a highly reversibleserine degradation pathway. The labeling data also suggest significantactivity in the anaplerotic (malic enzyme and phosphoenolpyruvatecarboxylase) and glyoxylate shunt (isocitrate lyase and malate synthase)reactions. Although the tricarboxylic acid (TCA) cycle is often observedto be incomplete in many other anaerobes (absence of 2-oxoglutaratedehydrogenase activity), isotopic labeling supports the existence of acomplete TCA cycle in S. oneidensis MR-1 under TMAO reductioncondition.

  1. Well-to-Wheels analysis of landfill gas-based pathways and their addition to the GREET model.

    SciTech Connect (OSTI)

    Mintz, M.; Han, J.; Wang, M.; Saricks, C.; Energy Systems

    2010-06-30

    Today, approximately 300 million standard cubic ft/day (mmscfd) of natural gas and 1600 MW of electricity are produced from the decomposition of organic waste at 519 U.S. landfills (EPA 2010a). Since landfill gas (LFG) is a renewable resource, this energy is considered renewable. When used as a vehicle fuel, compressed natural gas (CNG) produced from LFG consumes up to 185,000 Btu of fossil fuel and generates from 1.5 to 18.4 kg of carbon dioxide-equivalent (CO{sub 2}e) emissions per million Btu of fuel on a 'well-to-wheel' (WTW) basis. This compares with approximately 1.1 million Btu and 78.2 kg of CO{sub 2}e per million Btu for CNG from fossil natural gas and 1.2 million Btu and 97.5 kg of CO{sub 2}e per million Btu for petroleum gasoline. Because of the additional energy required for liquefaction, LFG-based liquefied natural gas (LNG) requires more fossil fuel (222,000-227,000 Btu/million Btu WTW) and generates more GHG emissions (approximately 22 kg CO{sub 2}e /MM Btu WTW) if grid electricity is used for the liquefaction process. However, if some of the LFG is used to generate electricity for gas cleanup and liquefaction (or compression, in the case of CNG), vehicle fuel produced from LFG can have no fossil fuel input and only minimal GHG emissions (1.5-7.7 kg CO{sub 2}e /MM Btu) on a WTW basis. Thus, LFG-based natural gas can be one of the lowest GHG-emitting fuels for light- or heavy-duty vehicles. This report discusses the size and scope of biomethane resources from landfills and the pathways by which those resources can be turned into and utilized as vehicle fuel. It includes characterizations of the LFG stream and the processes used to convert low-Btu LFG into high-Btu renewable natural gas (RNG); documents the conversion efficiencies and losses of those processes, the choice of processes modeled in GREET, and other assumptions used to construct GREET pathways; and presents GREET results by pathway stage. GREET estimates of well-to-pump (WTP), pump-to-wheel (PTW), and WTW energy, fossil fuel, and GHG emissions for each LFG-based pathway are then summarized and compared with similar estimates for fossil natural gas and petroleum pathways.

  2. Comparative genomic analysis of nine Sphingobium strains: Insights into their evolution and hexachlorocyclohexane (HCH) degradation pathways

    SciTech Connect (OSTI)

    Verma, Helianthous; Kumar, Roshan; Oldach, Phoebe; Sangwan, Naseer; Khurana, Jitendra P.; Gilbert, Jack A.; Lal, Rup

    2014-11-23

    Background: Sphingobium spp. are efficient degraders of a wide range of chlorinated and aromatic hydrocarbons. In particular, strains which harbour the lin pathway genes mediating the degradation of hexachlorocyclohexane (HCH) isomers are of interest due to the widespread persistence of this contaminant. Here, we examined the evolution and diversification of the lin pathway under the selective pressure of HCH, by comparing the draft genomes of six newly-sequenced Sphingobium spp. (strains LL03, DS20, IP26, HDIPO4, P25 and RL3) isolated from HCH dumpsites, with three existing genomes (S. indicum B90A, S. japonicum UT26S and Sphingobium sp. SYK6). Results: Efficient HCH degraders phylogenetically clustered in a closely related group comprising of UT26S, B90A, HDIPO4 and IP26, where HDIPO4 and IP26 were classified as subspecies with ANI value >98%. Less than 10% of the total gene content was shared among all nine strains, but among the eight HCH-associated strains, that is all except SYK6, the shared gene content jumped to nearly 25%. Genes associated with nitrogen stress response and two-component systems were found to be enriched. The strains also housed many xenobiotic degradation pathways other than HCH, despite the absence of these xenobiotics from isolation sources. In addition, these strains, although non-motile, but posses flagellar assembly genes. While strains HDIPO4 and IP26 contained the complete set of lin genes, DS20 was entirely devoid of lin genes (except linKLMN) whereas, LL03, P25 and RL3 were identified as lin deficient strains, as they housed incomplete lin pathways. Further, in HDIPO4, linA was found as a hybrid of two natural variants i.e., linA1 and linA2 known for their different enantioselectivity. Conclusion: The bacteria isolated from HCH dumpsites provide a natural testing ground to study variations in the lin system and their effects on degradation efficacy. Further, the diversity in the lin gene sequences and copy number, their arrangement with respect to IS6100 and evidence for potential plasmid content elucidate possible evolutionary acquisition mechanisms for this pathway. This study further opens the horizon for selection of bacterial strains for inclusion in an HCH bioremediation consortium and suggests that HDIPO4, IP26 and B90A would be appropriate candidates for inclusion.

  3. Timevarying coe#cient models for the analysis of air pollution and health outcome data

    E-Print Network [OSTI]

    Bath, University of

    Time­varying coe#cient models for the analysis of air pollution and health outcome data Duncan Lee and Gavin Shaddick Abstract In this paper, a time­varying coe#cient model is developed for air pollution and mortality data, which allows for an interaction between the e#ect of air pollution and time. Such temporal e

  4. Economics of Online Structural Health Monitoring of Wind Turbines: Cost Benefit Analysis

    E-Print Network [OSTI]

    McCalley, James D.

    ' desire a shift away from carbon intensive electricity generation. Wind power is increasingly becomingEconomics of Online Structural Health Monitoring of Wind Turbines: Cost Benefit Analysis Jeremy Van monitoring (OSHM) and condition-based maintenance (CBM) of wind turbine blades has the potential to reduce O

  5. Integrated analysis reveals that STAT3 is central to the crosstalk between HER/ErbB receptor signaling pathways in human mammary epithelial cells

    SciTech Connect (OSTI)

    Gong, Chunhong; Zhang, Yi; Shankaran, Harish; Resat, Haluk

    2015-01-01

    Human epidermal growth factor receptors (HER, also known as ErbB) drive cellular proliferation, pro-survival and stress responses by activating several downstream kinases, in particular ERK, p38, JNK (SAPK), the PI3K/AKT, as well as various transcriptional regulators such as STAT3. When co-expressed, first three members of HER family (HER1-3) can form homo- and hetero-dimers. Based on the considerable evidence which suggest that every receptor dimer activates intracellular signaling pathways differentially, we hypothesized that the HER dimerization pattern is a better predictor of downstream signaling than the total receptor activation levels. We validated our hypothesis using a combination of model-based analysis to quantify the HER dimerization patterns and multi-factorial experiments where HER dimerization patterns and signaling crosstalk were rationally perturbed. We have measured the activation of HER1-3 receptors and of the sentinel signaling proteins ERK, AKT, p38, JNK, STAT3 as a function of time in a panel of human mammary epithelial (HME) cells expressing different levels of HER1-3 stimulated with various ligand combinations. Our analysis using multiple ways of clustering the activation data has confirmed that the HER receptor dimer is a better predictor of the signaling through p38, ERK and AKT pathways than the total HER receptor expression and activation levels. Targeted inhibition studies to identify the causal effects allowed us to obtain a consensus regulatory interaction model, which revealed that STAT3 occupies a central role in the crosstalk between the studied pathways.

  6. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan Ogden and Lorraine Anderson #12;SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS #12;SUSTAINABLE;6 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS ACKNOWLEDGEMENTS #12;1 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS

  7. An analysis of uranium dispersal and health effects using a Gulf War case study.

    SciTech Connect (OSTI)

    Marshall, Albert Christian

    2005-07-01

    The study described in this report used mathematical modeling to estimate health risks from exposure to depleted uranium (DU) during the 1991 Gulf War for both U.S. troops and nearby Iraqi civilians. The analysis found that the risks of DU-induced leukemia or birth defects are far too small to result in an observable increase in these health effects among exposed veterans or Iraqi civilians. Only a few veterans in vehicles accidentally struck by U.S. DU munitions are predicted to have inhaled sufficient quantities of DU particulate to incur any significant health risk (i.e., the possibility of temporary kidney damage from the chemical toxicity of uranium and about a 1% chance of fatal lung cancer). The health risk to all downwind civilians is predicted to be extremely small. Recommendations for monitoring are made for certain exposed groups. Although the study found fairly large calculational uncertainties, the models developed and used are generally valid. The analysis was also used to assess potential uranium health hazards for workers in the weapons complex. No illnesses are projected for uranium workers following standard guidelines; nonetheless, some research suggests that more conservative guidelines should be considered.

  8. A Framework For The Exergy Analysis Of Future Transport Pathways: Application For The United Kingdom Transport System 2010-2050

    E-Print Network [OSTI]

    Byers, Edward A.; Gasparatos, Alexandros; Serrenho, André C.

    2015-08-04

    /friction/accessories/transmission losses (Table SI7 in supplementary material) and 189 𝜂𝑡?𝑒𝑜𝑟𝑒𝑡𝑖𝑐𝑎𝑙 𝑚𝑎𝑥𝑖𝑚𝑢𝑚 = 83% [43]. Furthermore, an exergy efficiency factor of 62% was used for 190 hydrogen production from electricity assuming steam-methane reforming... exergy efficiency of grid electricity production weighted by generation type 248 between 2010-2050. Pathways with high levels of renewables (particularly wind) and combined cycle 249 gas turbines exhibit the highest efficiencies (CP1-REN, CP3-CCS...

  9. Health

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFESOpportunitiesNERSCGrid-based29HaiWhy Is ItHarry1-1642Health

  10. Density Functional Theory Calculations and Analysis of Reaction Pathways for Reduction of Nitric Oxide by Hydrogen on Pt(111)

    SciTech Connect (OSTI)

    Farberow, Carrie A.; Dumesic, James A.; Mavrikakis, Manos

    2014-10-03

    Reaction pathways are explored for low temperature (e.g., 400 K) reduction of nitric oxide by hydrogen on Pt(111). First-principles electronic structure calculations based on periodic, self-consistent density functional theory(DFT-GGA, PW91) are employed to obtain thermodynamic and kinetic parameters for proposed reaction schemes on Pt(111). The surface of Pt(111) during NO reduction by H? at low temperatures is predicted to operate at a high NO coverage, and this environment is explicitly taken into account in the DFT calculations. Maximum rate analyses are performed to assess the most likely reaction mechanisms leading to formation of N?O, the major product observed experimentally at low temperatures. The results of these analyses suggest that the reaction most likely proceeds via the addition of at least two H atoms to adsorbed NO, followed by cleavage of the N-O bond.

  11. About HPMC OMS - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    safety and health, risk communication, health data analysis and trending, health education and promotion, industrial rehabilitation and ergonomics, behavioral health...

  12. Guidance on health effects of toxic chemicals. Safety Analysis Report Update Program

    SciTech Connect (OSTI)

    Foust, C.B.; Griffin, G.D.; Munro, N.B.; Socolof, M.L.

    1994-02-01

    Martin Marietta Energy Systems, Inc. (MMES), and Martin Marietta Utility Services, Inc. (MMUS), are engaged in phased programs to update the safety documentation for the existing US Department of Energy (DOE)-owned facilities. The safety analysis of potential toxic hazards requires a methodology for evaluating human health effects of predicted toxic exposures. This report provides a consistent set of health effects and documents toxicity estimates corresponding to these health effects for some of the more important chemicals found within MMES and MMUS. The estimates are based on published toxicity information and apply to acute exposures for an ``average`` individual. The health effects (toxicological endpoints) used in this report are (1) the detection threshold; (2) the no-observed adverse effect level; (3) the onset of irritation/reversible effects; (4) the onset of irreversible effects; and (5) a lethal exposure, defined to be the 50% lethal level. An irreversible effect is defined as a significant effect on a person`s quality of life, e.g., serious injury. Predicted consequences are evaluated on the basis of concentration and exposure time.

  13. Time series analysis and feature extraction techniques for structural health monitoring applications

    E-Print Network [OSTI]

    Overbey, Lucas A.

    2008-01-01

    rd Int’l Workshop on Structural Health Monitoring, StanfordExcitation for Structural Health Monitoring, Smart MaterialsExtraction in Structural Health Monitoring. Structural

  14. Needs analysis and project schedule for the Los Alamos National Laboratory (LANL) Health Physics Analysis Laboratory (HPAL) upgrade

    SciTech Connect (OSTI)

    Rhea, T.A.; Rucker, T.L.; Stafford, M.W.

    1990-09-28

    This report is a needs assessment and project schedule for the Health Physics Analysis Laboratory (HPAL) upgrade project at Los Alamos National Laboratory (LANL). After reviewing current and projected HPAL operations, two custom-developed laboratory information management systems (LIMS) for similar facilities were reviewed; four commercially available LIMS products were also evaluated. This project is motivated by new regulations for radiation protection and training and by increased emphasis on quality assurance (QA). HPAL data are used to: protect the health of radiation workers; document contamination levels for transportation of radioactive materials and for release of materials to the public for uncontrolled use; and verify compliance with environmental emission regulations. Phase 1 of the HPAL upgrade project concentrates on four types of counting instruments which support in excess of 90% of the sample workload at the existing central laboratories. Phase 2 is a refinement phase and also integrates summary-level databases on the central Health, Safety, and Environment (HSE) VAX. Phase 3 incorporates additional instrument types and integrates satellite laboratories into the HPAL LIMS. Phase 1 will be a multi-year, multimillion dollar project. The temptation to approach the upgrade of the HPAL program in a piece meal fashion should be avoided. This is a major project, with clearly-defined goals and priorities, and should be approached as such. Major programmatic and operational impacts will be felt throughout HSE as a result of this upgrade, so effective coordination with key customer contacts will be critical.

  15. Exposure Based Health Issues Project Report: Phase I of High Level Tank Operations, Retrieval, Pretreatment, and Vitrification Exposure Based Health Issues Analysis

    SciTech Connect (OSTI)

    Stenner, Robert D.; Bowers, Harold N.; Kenoyer, Judson L.; Strenge, Dennis L.; Brady, William H.; Ladue, Buffi; Samuels, Joseph K.

    2001-11-30

    The Department of Energy (DOE) has the responsibility to understand the ''big picture'' of worker health and safety which includes fully recognizing the vulnerabilities and associated programs necessary to protect workers at the various DOE sites across the complex. Exposure analysis and medical surveillance are key aspects for understanding this big picture, as is understanding current health and safety practices and how they may need to change to relate to future health and safety management needs. The exposure-based health issues project was initiated to assemble the components necessary to understand potential exposure situations and their medical surveillance and clinical aspects. Phase I focused only on current Hanford tank farm operations and serves as a starting point for the overall project. It is also anticipated that once the pilot is fully developed for Hanford HLW (i.e., current operations, retrieval, pretreatment, vitrification, and disposal), the process and analysis methods developed will be available and applicable for other DOE operations and sites. The purpose of this Phase I project report is to present the health impact information collected regarding ongoing tank waste maintenance operations, show the various aspects of health and safety involved in protecting workers, introduce the reader to the kinds of information that will need to be analyzed in order to effectively manage worker safety.

  16. Health effects model for nuclear power plant accident consequence analysis. Part I. Introduction, integration, and summary. Part II. Scientific basis for health effects models

    SciTech Connect (OSTI)

    Evans, J.S.; Moeller, D.W.; Cooper, D.W.

    1985-07-01

    Analysis of the radiological health effects of nuclear power plant accidents requires models for predicting early health effects, cancers and benign thyroid nodules, and genetic effects. Since the publication of the Reactor Safety Study, additional information on radiological health effects has become available. This report summarizes the efforts of a program designed to provide revised health effects models for nuclear power plant accident consequence modeling. The new models for early effects address four causes of mortality and nine categories of morbidity. The models for early effects are based upon two parameter Weibull functions. They permit evaluation of the influence of dose protraction and address the issue of variation in radiosensitivity among the population. The piecewise-linear dose-response models used in the Reactor Safety Study to predict cancers and thyroid nodules have been replaced by linear and linear-quadratic models. The new models reflect the most recently reported results of the follow-up of the survivors of the bombings of Hiroshima and Nagasaki and permit analysis of both morbidity and mortality. The new models for genetic effects allow prediction of genetic risks in each of the first five generations after an accident and include information on the relative severity of various classes of genetic effects. The uncertainty in modeloling radiological health risks is addressed by providing central, upper, and lower estimates of risks. An approach is outlined for summarizing the health consequences of nuclear power plant accidents. 298 refs., 9 figs., 49 tabs.

  17. Method of assessing a lipid-related health risk based on ion mobility analysis of lipoproteins

    DOE Patents [OSTI]

    Benner, W. Henry (Danville, CA); Krauss, Ronald M. (Berkeley, CA); Blanche, Patricia J. (Berkeley, CA)

    2010-12-14

    A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.

  18. Future prospects for compression ignition fuel in California : fuel-related implications of possible pathways to mitigation of public health threats.

    SciTech Connect (OSTI)

    Eberhardt, J. J.; Rote, D. M.; Saricks, C. L.; Stodolsky, F.

    1999-04-08

    This paper documents methods and results of an investigation of the options for and year 2010 consequences of possible new limitations on the use of diesel fuel in California, USA. California's Air Resources Board will undertake a risk management process to determine steps necessary to protect the health and safety of the public from carcinogenic species resident on diesel combustion exhaust particles. Environmental activist groups continue to call for the elimination of diesel fuel in California and other populous states. It is the declared intention of CARB not to ban or restrict diesel fuel, per se, at this time. Thus, two ''mid-course'' strategies now appear feasible: (1) Increased penetration of natural gas, LPG, and possibly lower alcohols into the transportation fuels market, to the extent that some Cl applications would revert to spark-ignition (SI) engines. (2) New specifications requiring diesel fuel reformulation based on more detailed investigation of exhaust products of individual diesel fuel constituents.

  19. Analysis of Potential Leakage Pathways and Mineralization within Caprocks for Geologic Storage of CO(sub 2}

    SciTech Connect (OSTI)

    Evans, James

    2012-11-30

    We used a multifaceted approach to investigate the nature of caprocks above, and the interface between, reservoir-­?quality rocks that might serve as targets for carbon storage. Fieldwork in southeastern Utah examined the regional-­? to m-­?scale nature of faults and fractures across the sedimentiological interfaces. We also used microscopic analyses and mechanical modeling to examine the question as to how the contacts between units interact, and how fractures may allow fluids to move from reservoirs to caprock. Regional-­?scale analyses using ASTER data enabled us to identify location of alteration, which led to site-­?specific studies of deformation and fluid flow. In the Jurassic Carmel Formation, a seal for the Navajo Sandstone, we evaluated mesoscale variability in fracture density and morphology and variability in elastic moduli in the Jurassic Carmel Formation, a proposed seal to the underlying Navajo Sandstone for CO{sub 2} geosequestration. By combining mechano-­?stratigraphic outcrop observations with elastic moduli derived from wireline log data, we characterize the variability in fracture pattern and morphology with the observed variability in rock strength within this heterolithic top seal. Outcrop inventories of discontinuities show fracture densities decrease as bed thickness increases and fracture propagation morphology across lithologic interfaces vary with changing interface type. Dynamic elastic moduli, calculated from wireline log data, show that Young’s modulus varies by up to 40 GPa across depositional interfaces, and by an average of 3 GPa across the reservoir/seal interface. We expect that the mesoscale changes in rock strength will affect the distributions of localized stress and thereby influence fracture propagation and fluid flow behavior within the seal. These data provide a means to closely tie outcrop observations to those derived from subsurface data and estimates of subsurface rock strength. We also studied damage zones associated normal faults in the Permian Cedar Mesa Sandstone, southeastern Utah. These faults are characterized by a single slip surfaces and damage zones containing deformation bands, veins, and joints. Field observations include crosscutting relationships, permeability increase, rock strength decrease, and ultraviolet light induced mineral fluorescence within the damage zone. These field observations combined with the interpreted paragenetic sequence from petrographic analysis, suggests a deformation history of reactivation and several mineralization events in an otherwise low-­?permeability fault. All deformation bands and veins fluoresce under ultraviolet light, suggesting connectivity and a shared mineralization history. Pre-­?existing deformation features act as loci for younger deformation and mineralization events, this fault and its damage zone illustrate the importance of the fault damage zone to subsurface fluid flow. We model a simplified stress history in order to understand the importance of rock properties and magnitude of tectonic stress on the deformation features within the damage zone. The moderate confining pressures, possible variations in pore pressure, and the porous, fine-­?grained nature of the Cedar Mesa Sandstone results in a fault damage zone characterized by enhanced permeability, subsurface fluid flow, and mineralization. Structural setting greatly influences fracture spacing and orientation. Three structural settings were examined and include fault proximity, a fold limb of constant dip, and a setting proximal to the syncline hinge. Fracture spacing and dominant fracture orientation vary at each setting and distinctions between regional and local paleo-­?stress directions can be made. Joints on the fold limb strike normal to the fold axis/bedding and are interpreted to be sub-­?parallel to the maximum regional paleo-­?stress direction as there is no fold related strain. Joints proximal to faults and the syncline hinge may have formed under local stress conditions associated with folding and faulting, and

  20. Probabilistic accident consequence uncertainty analysis -- Early health effects uncertainty assessment. Volume 2: Appendices

    SciTech Connect (OSTI)

    Haskin, F.E. [Univ. of New Mexico, Albuquerque, NM (United States); Harper, F.T. [Sandia National Labs., Albuquerque, NM (United States); Goossens, L.H.J.; Kraan, B.C.P. [Delft Univ. of Technology (Netherlands)

    1997-12-01

    The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library of uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA early health effects models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the panel on early health effects, (4) short biographies of the experts, and (5) the aggregated results of their responses.

  1. Worker Safety and Health and Nuclear Safety Quarterly Performance Analysis (January - March 2008)

    SciTech Connect (OSTI)

    Kerr, C E

    2009-10-07

    The DOE Office of Enforcement expects LLNL to 'implement comprehensive management and independent assessments that are effective in identifying deficiencies and broader problems in safety and security programs, as well as opportunities for continuous improvement within the organization' and to 'regularly perform assessments to evaluate implementation of the contractor's processes for screening and internal reporting.' LLNL has a self-assessment program, described in ES&H Manual Document 4.1, that includes line, management and independent assessments. LLNL also has in place a process to identify and report deficiencies of nuclear, worker safety and health and security requirements. In addition, the DOE Office of Enforcement expects LLNL to evaluate 'issues management databases to identify adverse trends, dominant problem areas, and potential repetitive events or conditions' (page 14, DOE Enforcement Process Overview, December 2007). LLNL requires that all worker safety and health and nuclear safety noncompliances be tracked as 'deficiencies' in the LLNL Issues Tracking System (ITS). Data from the ITS are analyzed for worker safety and health (WSH) and nuclear safety noncompliances that may meet the threshold for reporting to the DOE Noncompliance Tracking System (NTS). This report meets the expectations defined by the DOE Office of Enforcement to review the assessments conducted by LLNL, analyze the issues and noncompliances found in these assessments, and evaluate the data in the ITS database to identify adverse trends, dominant problem areas, and potential repetitive events or conditions. The report attempts to answer three questions: (1) Is LLNL evaluating its programs and state of compliance? (2) What is LLNL finding? (3) Is LLNL appropriately managing what it finds? The analysis in this report focuses on data from the first quarter of 2008 (January through March). This quarter is analyzed within the context of information identified in previous quarters to include April 2007 through March 2008. The results from analyzing the deficiencies are presented in accordance with the two primary NTS reporting thresholds for WSH and nuclear safety noncompliances: (1) those related to certain events or conditions and (2) those that are management issues. In addition, WSH noncompliances were also analyzed to determine if any fell under the 'other significant condition' threshold. This report also identifies noncompliance topical areas that may have issues that do not meet the NTS reporting threshold but should remain under observation. These are placed on the 'watch list' for continued analysis.

  2. Pathways Analysis for State Proliferators 

    E-Print Network [OSTI]

    Mella, Michael

    2012-07-16

    A computational tool to assess the most likely path a state proliferator would take in making a nuclear weapon was created in a Bayesian network. The purpose of this work was to create a tool to facilitate analysts and policymakers in learning about...

  3. Global Pathways Analysis Tool (GPAT)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:Financing Tool Fits the Bill Financing Tool Fits27, 2012GeothermalDepartment of Energy

  4. On-board state of health monitoring of lithium-ion batteries using incremental capacity analysis with support vector regressionq

    E-Print Network [OSTI]

    Peng, Huei

    On-board state of health monitoring of lithium-ion batteries using incremental capacity analysis 2013 Accepted 5 February 2013 Available online 11 February 2013 Keywords: Electric vehicles Lithium-ion and life cycle. In this paper, we focus on the identification of Li-ion battery capacity fading

  5. VIBRATION-BASED HEALTH MONITORING APPROACH FOR COMPOSITE STRUCTURES USING MULTIVARIATE STATISTICAL ANALYSIS.

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    VIBRATION-BASED HEALTH MONITORING APPROACH FOR COMPOSITE STRUCTURES USING MULTIVARIATE STATISTICAL makes Structural Health Monitoring (SHM) a must for such materials and structures. The development of a proper structural health monitoring system has a crucial importance for such structures because

  6. Time series analysis and feature extraction techniques for structural health monitoring applications

    E-Print Network [OSTI]

    Overbey, Lucas A.

    2008-01-01

    SHM structural health monitoring UAV unmanned aerial vehiclefor aerospace applications. (a) UAV Predator, (b) Lockheedof the unmanned aerial vehicle (UAV) Predator, as weight

  7. ORISE: Health Physics Training

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health Physics Training Student performs an analysis during an ORAU health physics training course Training and educating a highly skilled workforce that can meet operational...

  8. Health Maintenance Exam - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  9. A cost benefit analysis of employee assistance programs and health promotion programs 

    E-Print Network [OSTI]

    Sykora, Ellen M

    2013-02-22

    For many years business has been searching for ways to make companies more profitable. Some programs that many businesses have implemented in order to increase profits are Employee Assistance Programs (EAPs) and Health Promotion Programs (HPPs...

  10. Discourse of 'distortion' and health and medical news reports: a genre analysis perspective 

    E-Print Network [OSTI]

    Suhardja, Imelda

    2009-01-01

    The advent of medical journalism was initially felt to be an answer to the problem of communicating health and medical information to the public. However, currently, there is a concern among scientists with the way the ...

  11. An Examination of Health Providers' HPV Vaccination Behaviors, Perceived Barriers, and Supports: A Four State Analysis.

    E-Print Network [OSTI]

    McCave, Emily

    2009-12-08

    This study's main research asked which combination of predictors, including type of health provider, type of state policy initiative, overall barriers scores, and overall supports scores, is most predictive of HPV vaccination rates for providers...

  12. Solar Market Pathways

    Broader source: Energy.gov [DOE]

    The Solar Market Pathways website distributes key insights from 15 SunShot Initiative projects that are advancing solar deployment across the United States. These projects take a variety of...

  13. The Discourse of 'Distortion' and Health and Medical News Reports: A Genre Analysis Perspective 

    E-Print Network [OSTI]

    McDermott (nee Suhardja), Imelda

    2009-01-01

    , the thesis demonstrates that Health and Medical News Reports are first and foremost news stories and that the proposed guidelines fail to achieve the envisaged changes precisely because they seem to be ignorant of this essential reality. In order to reach...

  14. Program Design Analysis using BEopt Building Energy Optimization Software: Defining a Technology Pathway Leading to New Homes with Zero Peak Cooling Demand; Preprint

    SciTech Connect (OSTI)

    Anderson, R.; Christensen, C.; Horowitz, S.

    2006-08-01

    An optimization method based on the evaluation of a broad range of different combinations of specific energy efficiency and renewable-energy options is used to determine the least-cost pathway to the development of new homes with zero peak cooling demand. The optimization approach conducts a sequential search of a large number of possible option combinations and uses the most cost-effective alternatives to generate a least-cost curve to achieve home-performance levels ranging from a Title 24-compliant home to a home that uses zero net source energy on an annual basis. By evaluating peak cooling load reductions on the least-cost curve, it is then possible to determine the most cost-effective combination of energy efficiency and renewable-energy options that both maximize annual energy savings and minimize peak-cooling demand.

  15. Simplifying documentation while approaching site closure: integrated health & safety plans as documented safety analysis

    SciTech Connect (OSTI)

    Brown, Tulanda

    2003-06-01

    At the Fernald Closure Project (FCP) near Cincinnati, Ohio, environmental restoration activities are supported by Documented Safety Analyses (DSAs) that combine the required project-specific Health and Safety Plans, Safety Basis Requirements (SBRs), and Process Requirements (PRs) into single Integrated Health and Safety Plans (I-HASPs). By isolating any remediation activities that deal with Enriched Restricted Materials, the SBRs and PRs assure that the hazard categories of former nuclear facilities undergoing remediation remain less than Nuclear. These integrated DSAs employ Integrated Safety Management methodology in support of simplified restoration and remediation activities that, so far, have resulted in the decontamination and demolition (D&D) of over 150 structures, including six major nuclear production plants. This paper presents the FCP method for maintaining safety basis documentation, using the D&D I-HASP as an example.

  16. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan #12;279 PART 4 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS CHAPTER 13: BEYOND LIFE-CYCLE ANALYSIS://creativecommons.org/licenses/by-nc-nd/3.0/>. For information on commercial licensing, contact copyright@ucdavis.edu. #12;278 SUSTAINABLE

  17. 2014 Annual Workforce Analysis and Staffing Plan Report- Office of Environment, Health, Safety and Security

    Broader source: Energy.gov [DOE]

    Managers perform an annual workforce analysis of their organization and develop staffing plans that identify technical capabilities and positions they need to ensure safe operation of defense nuclear facilities.

  18. 2013 Annual Workforce Analysis and Staffing Plan Report- Office of Health, Safety and Security

    Broader source: Energy.gov [DOE]

    Managers perform an annual workforce analysis of their organization and develop staffing plans that identify technical capabilities and positions they need to ensure safe operation of defense nuclear facilities.

  19. NTID Health Care Initiatives October 1, 2011

    E-Print Network [OSTI]

    Salvaggio, Carl

    NTID Health Care Initiatives October 1, 2011 (Based on Interim Report, Task Force on Health Care Careers for the Deaf and Hard-of-Hearing Community, June, 2011) "Building Pathways to Health Care Careers for the Deaf and Hard-of- Hearing Community: Interim Report" submitted by the Task Force on Health Care Careers

  20. Solar Market Pathways Website

    Broader source: Energy.gov [DOE]

    The Solar Market Pathways website distributes key insights from 15 SunShot Initiative projects that are advancing solar deployment across the United States. These projects take a variety of approaches to develop actionable strategic plans to expand solar electricity use for residential, community, and commercial properties.

  1. Social networks, happiness and health: from sentiment analysis to a multidimensional indicator of subjective well-being

    E-Print Network [OSTI]

    Iacus, Stefano Maria; Salini, Silvia; Siletti, Elena

    2015-01-01

    This paper applies a novel technique of opinion analysis over social media data with the aim of proposing a new indicator of perceived and subjective well-being. This new index, namely SWBI, examines several dimension of individual and social life. The indicator has been compared to some other existing indexes of well-being and health conditions in Italy: the BES (Benessere Equo Sostenibile), the incidence rate of influenza and the abundance of PM10 in urban environments. SWBI is a daily measure available at province level. BES data, currently available only for 2013 and 2014, are annual and available at regional level. Flu data are weekly and distributed as regional data and PM10 are collected daily for different cities. Due to the fact that the time scale and space granularity of the different indexes varies, we apply a novel statistical technique to discover nowcasting features and the classical latent analysis to study the relationships among them. A preliminary analysis suggest that the environmental and...

  2. Gamma-Ray Signatures for State-Of-Health Analysis and Monitoring of Widely-Arrayed Radiation Portal Monitor Systems

    SciTech Connect (OSTI)

    Woodring, Mitchell L.; Ely, James H.; Angel, Linda K.; Wright, Ingrid H.; Eslinger, Melany A.; Pospical, A. Jill; Ellis, John E.

    2008-05-15

    Pacific Northwest National Laboratory (PNNL) has deployed a large array of radiation portal monitors for the Department of Homeland Security U.S. Customs and Border Protection. These portal monitors scan incoming vehicles crossing the U.S. border and shipping containers leaving international ports for radioactive material via gamma-ray and neutron detection. Data produced and captured by these systems are recorded for every vehicle related to radiation signature, sensor/system status, and local background, as well as a host of other variables. Within the Radiation Portal Monitor Project at PNNL, state-of-health observation and analysis for the whole RPM system using these data to determine functionality and performance is being developed. (PIET-43741-TM-492)

  3. Faculty of Health York University

    E-Print Network [OSTI]

    . Health Strategic Priorities Activity Focus Areas Strategic Enrolment Management Teaching & Learning .......................................................................................................................................................................................................................... 3 Strategic Analysis Process .................................................................................................................................................................................................... 3 Faculty of Health Strategic Initiatives Summary

  4. Health Behavior Health Promotion -Prevention

    E-Print Network [OSTI]

    Meagher, Mary

    Health Behavior Health Promotion - Prevention Modification of Health Attitudes and Health Behavior #12;Health Promotion: An Overview Basic philosophy Good health = individual and collective goal interventions Public Health Strategies #12;Introduction to Health Behaviors: Role of Behavioral Factors

  5. HEALTH & COUNSELLING Health Clinic

    E-Print Network [OSTI]

    HEALTH & COUNSELLING SERVICES Health Clinic 778.783.4615 - Burnaby 778.782.5200 - Vancouver_counsellor@sfu.ca Health Promotion 778.782.4674 Health & Counselling Services, SFU - 8888 University Drive, MBC 0164 health can suffer if you're under stress for a long time, especially if you are not eating well. You may

  6. Interdisciplinary: Chemical Engineer/Mechanical Engineer (Pathways...

    Energy Savers [EERE]

    Interdisciplinary: Chemical EngineerMechanical Engineer (Pathways Recent Graduate Program) Interdisciplinary: Chemical EngineerMechanical Engineer (Pathways Recent Graduate...

  7. Leakage pathway layer for solar cell

    DOE Patents [OSTI]

    Luan, Andy; Smith, David; Cousins, Peter; Sun, Sheng

    2015-12-01

    Leakage pathway layers for solar cells and methods of forming leakage pathway layers for solar cells are described.

  8. Improving carbon fixation pathways

    SciTech Connect (OSTI)

    Ducat, DC; Silver, PA

    2012-08-01

    A recent resurgence in basic and applied research on photosynthesis has been driven in part by recognition that fulfilling future food and energy requirements will necessitate improvements in crop carbon-fixation efficiencies. Photosynthesis in traditional terrestrial crops is being reexamined in light of molecular strategies employed by photosynthetic microbes to enhance the activity of the Calvin cycle. Synthetic biology is well-situated to provide original approaches for compartmentalizing and enhancing photosynthetic reactions in a species independent manner. Furthermore, the elucidation of alternative carbon-fixation routes distinct from the Calvin cycle raises possibilities that novel pathways and organisms can be utilized to fix atmospheric carbon dioxide into useful materials.

  9. What are pathways?

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power AdministrationRobust,Field-effectWorking WithTelecentricNCubic Feet)CompletesResearchWhat are pathways?

  10. Racism as a determinant of health: a protocol for conducting a systematic review and meta-analysis

    E-Print Network [OSTI]

    2013-01-01

    research on self-reported racism and health. Int J Epidemiol32:20–47. 4. Berman G, Paradies Y: Racism, disadvantage andand characterizing racism in health research. Crit Public

  11. Health effects models for nuclear power plant accident consequence analysis: Low LET radiation: Part 2, Scientific bases for health effects models

    SciTech Connect (OSTI)

    Abrahamson, S.; Bender, M.; Book, S.; Buncher, C.; Denniston, C.; Gilbert, E.; Hahn, F.; Hertzberg, V.; Maxon, H.; Scott, B.

    1989-05-01

    This report provides dose-response models intended to be used in estimating the radiological health effects of nuclear power plant accidents. Models of early and continuing effects, cancers and thyroid nodules, and genetic effects are provided. Two-parameter Weibull hazard functions are recommended for estimating the risks of early and continuing health effects. Three potentially lethal early effects -- the hematopoietic, pulmonary and gastrointestinal syndromes -- are considered. Linear and linear-quadratic models are recommended for estimating cancer risks. Parameters are given for analyzing the risks of seven types of cancer in adults -- leukemia, bone, lung, breast, gastrointestinal, thyroid and ''other''. The category, ''other'' cancers, is intended to reflect the combined risks of multiple myeloma, lymphoma, and cancers of the bladder, kidney, brain, ovary, uterus and cervix. Models of childhood cancers due to in utero exposure are also provided. For most cancers, both incidence and mortality are addressed. Linear and linear-quadratic models are also recommended for assessing genetic risks. Five classes of genetic disease -- dominant, x-linked, aneuploidy, unbalanced translocation and multifactorial diseases --are considered. In addition, the impact of radiation-induced genetic damage on the incidence of peri-implantation embryo losses is discussed. The uncertainty in modeling radiological health risks is addressed by providing central, upper, and lower estimates of all model parameters. Data are provided which should enable analysts to consider the timing and severity of each type of health risk. 22 refs., 14 figs., 51 tabs.

  12. Re-Visiting Health Informatics What is Health Informatics?

    E-Print Network [OSTI]

    Abidi, Syed Sibte Raza

    Re-Visiting Health Informatics HINF1100 Fall 2008 #12;What is Health Informatics? · Health the effective organization, analysis, management and use of health information to improve the delivery and practice of healthcare · Health Informatics is the study of applying information and technology to improve

  13. Analysis of the Durability of PEM FC Membrane Electrode Assemblies in Automotive Applications through the Fundamental Understanding of Membrane and MEA Degradation Pathways

    SciTech Connect (OSTI)

    Perry, Randal L.

    2013-10-31

    The Project focused on mitigation of degradation processes on membrane electrode assemblies. The approach was to develop a model to improve understanding of the mechanisms, and to use it to focus mitigation strategies. The detailed effects of various accelerated stress tests (ASTs) were evaluated to determine the best subset to use in model development. A combination of ASTs developed by the Fuel Cell Commercialization Conference of Japan and the Fuel Cell Tech Team were selected for use. The ASTs were compared by measuring effects on performance, running in-situ diagnostics, and performing microscopic analyses of the membrane electrode assemblies after the stress tests were complete. Nissan ran FCCJ AST protocols and performed in situ and ex-situ electrochemical testing. DuPont ran FCTT and USFCC AST protocols, performed scanning and transmission electron microscopy and ran in-situ electrochemical tests. Other ex-situ testing was performed by IIT, along with much of the data analysis and model development. These tests were then modified to generate time-dependent data of the degradation mechanisms. Three different catalyst types and four membrane variants were then used to generate data for a theoretically-based degradation model. An important part of the approach was to use commercially available materials in the electrodes and membranes made in scalable semiworks processes rather than lab-based materials. This constraint ensured all materials would be practicable for full-scale testing. The initial model for the electrode layer was tested for internal consistency and agreement with the data. A Java-based computer application was developed to analyze the time-dependent AST data using polarization curves with four different cathode gas feeds and generate model parameters. Data showed very good reproducibility and good consistency as cathode catalyst loadings were varied. At the point of termination of the project, a basic electrode model was in hand with several areas identified for improvement. Time dependence and the membrane portion of the model were not addressed due to cancellation of Phase 2 of the Project.

  14. Pathways for Algal Biofuels

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    * Carbon retained during hydrotreating * 80% in diesel range * Aqueous carbon capture as biogas Bio-Oil Upgrading HTL Bio-Oil Production-CSTR Configuration Fuel Analysis (Sim...

  15. Health Education & Wellness - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Wellness Health Education & Wellness Health Education & Wellness Downloads & Patient Materials Health & Productivity Health Calculators & Logs Health Coaching Health Fairs and...

  16. Health & Productivity - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health & Productivity Health Education & Wellness Downloads & Patient Materials Health & Productivity Health Calculators & Logs Health Coaching Health Fairs and Screenings...

  17. A Comparative Analysis of Mestizo and Indigenous Mayan Young Women in Guatemala: Attitudes and Knowledge of Sexual Reproduction and Health among Members of Children International's Youth Health Corps

    E-Print Network [OSTI]

    Trapp, Sarah Casement

    2011-04-21

    youth in Guatemala participate in the program together. In this comparative analysis of Kaqchikel Maya young women and non–indigenous young women in Guatemala, a written anonymous survey was administered to both groups of female participants to determine...

  18. Protein design for pathway engineering

    SciTech Connect (OSTI)

    Eriksen, DT; Lian, JZ; Zhao, HM

    2014-02-01

    Design and construction of biochemical pathways has increased the complexity of biosynthetically-produced compounds when compared to single enzyme biocatalysis. However, the coordination of multiple enzymes can introduce a complicated set of obstacles to overcome in order to achieve a high titer and yield of the desired compound. Metabolic engineering has made great strides in developing tools to optimize the flux through a target pathway, but the inherent characteristics of a particular enzyme within the pathway can still limit the productivity. Thus, judicious protein design is critical for metabolic and pathway engineering. This review will describe various strategies and examples of applying protein design to pathway engineering to optimize the flux through the pathway. The proteins can be engineered for altered substrate specificity/selectivity, increased catalytic activity, reduced mass transfer limitations through specific protein localization, and reduced substrate/product inhibition. Protein engineering can also be expanded to design biosensors to enable high through-put screening and to customize cell signaling networks. These strategies have successfully engineered pathways for significantly increased productivity of the desired product or in the production of novel compounds. (C) 2013 Elsevier Inc. All rights reserved.

  19. Space, light, and time : prospective analysis of Circadian illumination for health-based daylighting with applications to healthcare architecture

    E-Print Network [OSTI]

    Pechacek, Christopher S. (Christopher Scott)

    2008-01-01

    Light in architecture can be studied for its objective or perceptual effects. This thesis describes an objective link between human health and architectural design. Specifically, the link between daylight and human circadian ...

  20. Test of the "Healthy Migrant Hypothesis": A Longitudinal Analysis of Health Selectivity of Internal Migration in Indonesia

    E-Print Network [OSTI]

    Lu, Yao

    2007-01-01

    of health services in Indonesia. Social Science andThomas, D. (2000). The Indonesia Family Life Survey (IFLS):The Real costs of Indonesia’s economic crisis: Findings from

  1. An Analysis of the health impacts from PM and NOx emissions resulting from train operations in the Alameda Corridor, CA

    E-Print Network [OSTI]

    Sangkapichai, Mana; Saphores, Jean-Daniel M; Ogunseitan, Oladele; Ritchie, Stephen G.; You, Soyoung Iris; Lee, Gunwoo

    2010-01-01

    health impacts of PM and NOx emissions resulting from trainhealth impacts of PM and NOx emissions from train operationsreduce locomotive PM and NOx emissions by as much as 90% and

  2. Health Coaching - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Coaching Health Education & Wellness Downloads & Patient Materials Health & Productivity Health Calculators & Logs Health Coaching Health Fairs and Screenings Interactive Exercises...

  3. Assessment of SRS radiological liquid and airborne contaminants and pathways

    SciTech Connect (OSTI)

    Jannik, G.T.

    1997-04-01

    This report compiles and documents the radiological critical-contaminant/critical-pathway analysis performed for SRS. The analysis covers radiological releases to the atmosphere and to surface water, which are the principal media that carry contaminants off site. During routine operations at SRS, limited amounts of radionuclides are released to the environment through atmospheric and/or liquid pathways. These releases potentially result in exposure to offsite people. Though the groundwater beneath an estimated 5 to 10 percent of SRS has been contaminated by radionuclides, there is no evidence that groundwater contaminated with these constituents has migrated offsite (Arnett, 1996). Therefore, with the notable exception of radiological source terms originating from shallow surface water migration into site streams, onsite groundwater was not considered as a potential exposure pathway to offsite people.

  4. Climate Change Mitigation: Climate, Health, and Equity Implications of the Visible and the Hidden

    E-Print Network [OSTI]

    Shonkoff, Seth Berrin

    2012-01-01

    2004). "Emissions pathways, climate change, and impacts onfor human health and climate change." J Toxicol Environet al. (2001). Climate change 2001: impacts, adaptation, and

  5. Health & Safety

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health & Safety Health & Safety1354608000000Health & SafetySome of these resources are LANL-only and will require Remote Access.NoQuestions? 667-5809library@lanl.gov Health &...

  6. Doctor of Applied Social Research Social Work Pathway

    E-Print Network [OSTI]

    Little, Tony

    services. SWKPCJ: Crime, Welfare and Justice: explores the risk of crime and the impact of social policyDASR Doctor of Applied Social Research Social Work Pathway · The programme is intended in social work and related social issues. It is directed towards building capacity in the analysis of policy

  7. Supplementary Information Programming Biomolecular Self-Assembly Pathways

    E-Print Network [OSTI]

    Pierce, Niles A.

    Supplementary Information Programming Biomolecular Self-Assembly Pathways Peng Yin1,2 , Harry M.T. Choi1 , Colby R. Calvert1 & Niles A. Pierce1,3, 1Department of Bioengineering, 2Department of Computer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 S6.7 Statistical analysis

  8. Molecular pathways of angiogenesis inhibition

    SciTech Connect (OSTI)

    Tabruyn, Sebastien P.; Griffioen, Arjan W. . E-mail: aw.griffioen@path.unimaas.nl

    2007-03-30

    A large body of evidence now demonstrates that angiostatic therapy represents a promising way to fight cancer. This research recently resulted in the approval of First angiostatic agent for clinical treatment of cancer. Progress has been achieved in decrypting the cellular signaling in endothelial cells induced by angiostatic agents. These agents predominantly interfere with the molecular pathways involved in migration, proliferation and endothelial cell survival. In the current review, these pathways are discussed. A thorough understanding of the mechanism of action of angiostatic agents is required to develop efficient anti-tumor therapies.

  9. Terrestrial Remotely Sensed Imagery in Support of Public Health: New Avenues of Research Using Object-Based Image Analysis

    E-Print Network [OSTI]

    Kelly, Maggi

    2011-01-01

    Pollution) *Note: OBIA: Object-based image analysis; ETM: Enhanced Thematic Mapper; Lidar: Light Detection and Ranging; ASTER: Advanced Spaceborne Thermal

  10. International Health Global Health Policy--------------------------------------------------------------------------------------

    E-Print Network [OSTI]

    Miyashita, Yasushi

    50 International Health Global Health Policy-------------------------------------------------------------------------------------- http://www.ghp.m.u-tokyo.ac.jp Our mission is to improve population health by enhancing accountability and improving evidence base of global (both domestic and international) health programmes through the provision

  11. Transportation Energy Pathways LDRD.

    SciTech Connect (OSTI)

    Barter, Garrett; Reichmuth, David; Westbrook, Jessica; Malczynski, Leonard A.; Yoshimura, Ann S.; Peterson, Meghan; West, Todd H.; Manley, Dawn Kataoka; Guzman, Katherine Dunphy; Edwards, Donna M.; Hines, Valerie Ann-Peters

    2012-09-01

    This report presents a system dynamics based model of the supply-demand interactions between the USlight-duty vehicle (LDV) fleet, its fuels, and the corresponding primary energy sources through the year2050. An important capability of our model is the ability to conduct parametric analyses. Others have reliedupon scenario-based analysis, where one discrete set of values is assigned to the input variables and used togenerate one possible realization of the future. While these scenarios can be illustrative of dominant trendsand tradeoffs under certain circumstances, changes in input values or assumptions can have a significantimpact on results, especially when output metrics are associated with projections far into the future. Thistype of uncertainty can be addressed by using a parametric study to examine a range of values for the inputvariables, offering a richer source of data to an analyst.The parametric analysis featured here focuses on a trade space exploration, with emphasis on factors thatinfluence the adoption rates of electric vehicles (EVs), the reduction of GHG emissions, and the reduction ofpetroleum consumption within the US LDV fleet. The underlying model emphasizes competition between13 different types of powertrains, including conventional internal combustion engine (ICE) vehicles, flex-fuel vehicles (FFVs), conventional hybrids(HEVs), plug-in hybrids (PHEVs), and battery electric vehicles(BEVs).We find that many factors contribute to the adoption rates of EVs. These include the pace of technologicaldevelopment for the electric powertrain, battery performance, as well as the efficiency improvements inconventional vehicles. Policy initiatives can also have a dramatic impact on the degree of EV adoption. Theconsumer effective payback period, in particular, can significantly increase the market penetration rates ifextended towards the vehicle lifetime.Widespread EV adoption can have noticeable impact on petroleum consumption and greenhouse gas(GHG) emission by the LDV fleet. However, EVs alone cannot drive compliance with the most aggressiveGHG emission reduction targets, even as the current electricity source mix shifts away from coal and towardsnatural gas. Since ICEs will comprise the majority of the LDV fleet for up to forty years, conventional vehicleefficiency improvements have the greatest potential for reductions in LDV GHG emissions over this time.These findings seem robust even if global oil prices rise to two to three times current projections. Thus,investment in improving the internal combustion engine might be the cheapest, lowest risk avenue towardsmeeting ambitious GHG emission and petroleum consumption reduction targets out to 2050.3 AcknowledgmentThe authors would like to thank Dr. Andrew Lutz, Dr. Benjamin Wu, Prof. Joan Ogden and Dr. ChristopherYang for their suggestions over the course of this project. This work was funded by the Laboratory DirectedResearch and Development program at Sandia National Laboratories.4

  12. University Health Service Health Educator

    E-Print Network [OSTI]

    Cantlon, Jessica F.

    University Health Service Health Educator A full-time, 12 month Health Educator position is available at the University Health Service, University of Rochester. The Health Educator plans, implements, and evaluates theory- and evidence-based health promotion strategies, programs, and services for University

  13. Latina/o Health Discourses in Newsprint Media from 2006-2010: A Content Analysis of Four Syndicated Newspapers 

    E-Print Network [OSTI]

    Ortega, Frank J

    2013-12-11

    remains a pertinent element to comprehending contemporary racism and racial oppression (Feagin, 2010; 2006). Systemic racism and the white racial frame will provide an insightful sociological lens into how the media contributes to the social... employee health insurance, but have been regularly deporting them back to their home country often with devastating results (Molina, 2011). Medical officials representing hospitals claim that the deportations are purely financial: immigrants are unable...

  14. Characterization of Protein Folding by Dominant Reaction Pathways

    E-Print Network [OSTI]

    Pietro Faccioli

    2008-06-23

    We assess the reliability of the recently developed approach denominated Dominant Reaction Pathways (DRP) by studying the folding of a 16-residue beta-hairpin, within a coarse-grained Go-type model. We show that the DRP predictions are in quantitative agreement with the results of Molecular Dynamics simulations, performed in the same model. On the other hand, in the DRP approach, the computational difficulties associated to the decoupling of time scales are rigorously bypassed. The analysis of the important transition pathways supports a picture of the beta-hairpin folding in which the reaction is initiated by the collapse of the hydrophobic cluster.

  15. Sustainable Transportation Energy Pathways Research

    E-Print Network [OSTI]

    Handy, Susan L.

    FUEL/VEHICLE PATHWAYS (ROAD VEH.) #12;Transport Fuels Today (94% petro-based, 2% biofuel) IEA Energy Technology Perspectives (2010) #12;IEA ETP 2012: THREE ENERGY SCENARIOS 6 DS (Current Policies), 4 DS, 2DS Source: IEA Energy Technology Perspectives (2012) #12;MEETING 2050 GHG REDUCTION GOALS => FUEL MIX

  16. Understanding Children's Lives: How children and parents experience and understand social and health inequalities 

    E-Print Network [OSTI]

    Backett-Milburn, Kathryn; Cunningham-Burley, Sarah

    Children's differing social circumstances and experiences are part of the pathways implicated in health and illness in adulthood. However, children's own perspectives tend to be absent from adult-defined data about health ...

  17. Risk Communication - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  18. Qualification Exam - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  19. Emergency Preparedness - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  20. Medical Monitoring Exam - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  1. Infection Control & Immunizations - HPMC Occupational Health...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  2. Medical Exam Scheduling - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  3. Influenza Immunization Program - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  4. Worksite Visits - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  5. Medical Exams - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  6. Men's Health - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health Education & Wellness > Downloads & Patient Materials > Men's Health Health Education & Wellness Downloads & Patient Materials Ergonomics Fitness & Exercise Men's Health...

  7. Bioenergy Technologies Office R&D Pathways: Algal Lipid Upgrading...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    & Publications Pathways for Algal Biofuels Algal Lipid Extraction and Upgrading to Hydrocarbons Technology Pathway Bioenergy Technologies Office Conversion R&D Pathway: Whole...

  8. The role of technology in reducing health care costs. Final project report

    SciTech Connect (OSTI)

    Sill, A.E.; Warren, S.; Dillinger, J.D.; Cloer, B.K.

    1997-08-01

    Sandia National Laboratories applied a systems approach to identifying innovative biomedical technologies with the potential to reduce U.S. health care delivery costs while maintaining care quality. This study was conducted by implementing both top-down and bottom-up strategies. The top-down approach used prosperity gaming methodology to identify future health care delivery needs. This effort provided roadmaps for the development and integration of technology to meet perceived care delivery requirements. The bottom-up approach identified and ranked interventional therapies employed in existing care delivery systems for a host of health-related conditions. Economic analysis formed the basis for development of care pathway interaction models for two of the most pervasive, chronic disease/disability conditions: coronary artery disease (CAD) and benign prostatic hypertrophy (BPH). Societal cost-benefit relationships based on these analyses were used to evaluate the effect of emerging technology in these treatment areas. 17 figs., 48 tabs.

  9. A cross-sectional analysis of light at night, neighborhood sociodemographics and urinary 6-sulfatoxymelatonin concentrations: implications for the conduct of health studies

    E-Print Network [OSTI]

    Hurley, Susan; Nelson, David O; Garcia, Erika; Gunier, Robert; Hertz, Andrew; Reynolds, Peggy

    2013-01-01

    health effects of light pollution. Environ Health Perspectoutdoor envir- onmental light pollution is sufficient tooutdoor envir- onmental light pollution in wildlife and in

  10. Urban health and health inequalities

    E-Print Network [OSTI]

    Urban health and health inequalities and the role of urban forestry in Britain: A review Liz O'Brien Kathryn Williams Amy Stewart 2010 #12;Urban health and woodlands Contents Executive Summary 4 1.1.3 Definition of terms 9 3. The policy context: health and forestry policies 11 3.1 Health policies 11 3

  11. Prioritizing Acquisition Pathways in the State Level Concept

    SciTech Connect (OSTI)

    Murphy, Chantell L.; Budlong-Sylvester, Kory; Pilat, Joseph F.

    2012-06-27

    The International Atomic Energy Agency's (IAEA) Department of Safeguards has launched a project to further develop the State-level concept for the planning, implementation, and evaluation of safeguards activities. In order to further evolve the safeguards system an emphasis is placed on integrating inspection-related activities and the State evaluation process to draw safeguards conclusions in the most efficient way. The credible implementation of acquisition pathway analysis is central to the success of the IAEA's State-level concept. NNSA's Office of Nuclear Safeguards and Security (NA-241) The Next Generation Safeguards Initiative (NGSI) is sponsoring Los Alamos National Laboratory (LANL) to produce a study that will examine the use of acquisition pathway analysis in: (1) Developing a State-specific, State-level approach (SLA) and Annual Implementation Plan (AIP); (2) Maximizing the utility of the physical model; and (3) Supporting resource allocation decisions through a pathway prioritization. To deal with the challenge of developing an effective and efficient SLA, this study looks at: (1) Prioritizing proliferation pathways based on an assessment of a State's capabilities and assumed proliferation strategies; and (2) Relevant State behavior (e.g., transparency, cooperation, etc.) while avoiding subjective judgments about States themselves. The study makes use of case studies and concrete examples in order to illustrate how new concepts and approaches will be implemented, and how they may differ from more traditional safeguards approaches.

  12. Health Calculators & Logs - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Calculators & Logs Health Education & Wellness Downloads & Patient Materials Health & Productivity Health Calculators & Logs Body Mass Index Health Coaching Health Fairs and...

  13. NREL: Energy Analysis - Mackay Miller

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and multilateral initiatives including the US-China Renewable Energy Partnership and 21st Century Power Partnership Quantitative social network analysis of innovation pathways...

  14. Bioenergy Technologies Office R&D Pathways: Algal Lipid Upgrading...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Upgrading More Documents & Publications Algal Lipid Extraction and Upgrading to Hydrocarbons Technology Pathway Pathways for Algal Biofuels Bioenergy Technologies Office...

  15. Combustion kinetics and reaction pathways

    SciTech Connect (OSTI)

    Klemm, R.B.; Sutherland, J.W. [Brookhaven National Laboratory, Upton, NY (United States)

    1993-12-01

    This project is focused on the fundamental chemistry of combustion. The overall objectives are to determine rate constants for elementary reactions and to elucidate the pathways of multichannel reactions. A multitechnique approach that features three independent experiments provides unique capabilities in performing reliable kinetic measurements over an exceptionally wide range in temperature, 300 to 2500 K. Recent kinetic work has focused on experimental studies and theoretical calculations of the methane dissociation system (CH{sub 4} + Ar {yields} CH{sub 3} + H + Ar and H + CH{sub 4} {yields} CH{sub 3} + H{sub 2}). Additionally, a discharge flow-photoionization mass spectrometer (DF-PIMS) experiment is used to determine branching fractions for multichannel reactions and to measure ionization thresholds of free radicals. Thus, these photoionization experiments generate data that are relevant to both reaction pathways studies (reaction dynamics) and fundamental thermochemical research. Two distinct advantages of performing PIMS with high intensity, tunable vacuum ultraviolet light at the National Synchrotron Light Source are high detection sensitivity and exceptional selectivity in monitoring radical species.

  16. Fact Sheet HEALTH SCIENCE

    E-Print Network [OSTI]

    Su, Xiao

    contributions to the campus, community, and professions of public health and health Concentration · Health Services Administration Concentration · Health Professions

  17. Fuel Dependence of Benzene Pathways

    SciTech Connect (OSTI)

    Zhang, H; Eddings, E; Sarofim, A; Westbrook, C

    2008-07-14

    The relative importance of formation pathways for benzene, an important precursor to soot formation, was determined from the simulation of 22 premixed flames for a wide range of equivalence ratios (1.0 to 3.06), fuels (C{sub 1}-C{sub 12}), and pressures (20 to 760 torr). The maximum benzene concentrations in 15 out of these flames were well reproduced within 30% of the experimental data. Fuel structural properties were found to be critical for benzene production. Cyclohexanes and C{sub 3} and C{sub 4} fuels were found to be among the most productive in benzene formation; and long-chain normal paraffins produce the least amount of benzene. Other properties, such as equivalence ratio and combustion temperatures, were also found to be important in determining the amount of benzene produced in flames. Reaction pathways for benzene formation were examined critically in four premixed flames of structurally different fuels of acetylene, n-decane, butadiene, and cyclohexane. Reactions involving precursors, such as C{sub 3} and C{sub 4} species, were examined. Combination reactions of C{sub 3} species were identified to be the major benzene formation routes with the exception of the cyclohexane flame, in which benzene is formed exclusively from cascading fuel dehydrogenation via cyclohexene and cyclohexadiene intermediates. Acetylene addition makes a minor contribution to benzene formation, except in the butadiene flame where C{sub 4}H{sub 5} radicals are produced directly from the fuel, and in the n-decane flame where C{sub 4}H{sub 5} radicals are produced from large alkyl radical decomposition and H atom abstraction from the resulting large olefins.

  18. Electricity Innovation and Health Care in the Developing World

    E-Print Network [OSTI]

    Hall, Sharon J.

    for a new energy education policy pathway for electricity innovation. Mechtenberg's research focusesElectricity Innovation and Health Care in the Developing World Friday, December 7, 2012 12:00 - 1 and Industrial Engineering, Northeastern University Unreliable electrical infrastructures threaten global health

  19. National Technology Centers for Networks and Pathways

    E-Print Network [OSTI]

    Ungerleider, Leslie G.

    TCNP National Technology Centers for Networks and Pathways Technology and Resources for Proteomics of Dynamic Systems #12;Table of Contents An Introduction to the National Technology Centers for Networks) ................................................................................................................................................................36 1 | National Technology Centers for Networks and Pathways #12;An Introduction to the National

  20. Fuel Pathway Integration Technical Team Roadmap

    SciTech Connect (OSTI)

    2013-06-01

    The Fuel Pathway Integration Technical Team (FPITT) supports the U.S. DRIVE Partnership (the Partnership) in the identification and evaluation of implementation scenarios for fuel cell technology pathways, including hydrogen and fuel cell electric vehicles in the transportation sector, both during a transition period and in the long term.

  1. ORIGINAL ARTICLE Alternative pathways for phosphonate metabolism

    E-Print Network [OSTI]

    ORIGINAL ARTICLE Alternative pathways for phosphonate metabolism in thermophilic cyanobacteria from. are suggestive of niche-specific constraints in the evolution of nutrient assimilation pathways and syntrophic terrestrial environments. The ISME Journal advance online publication, 15 July 2010; doi:10.1038/ismej.2010

  2. Dominant Pathways in Protein Folding

    E-Print Network [OSTI]

    P. Faccioli; M. Sega; F. Pederiva; H. Orland

    2006-07-27

    We present a method to investigate the kinetics of protein folding on a long time-scale and the dynamics underlying the formation of secondary and tertiary structures during the entire reaction. The approach is based on the formal analogy between thermal and quantum diffusion: by writing the solution of the Fokker-Planck equation for the time-evolution of a protein in a viscous heat-bath in terms of a path integral, we derive a Hamilton-Jacobi variational principle from which we are able to compute the most probable pathway of folding. The method is applied to the folding of the Villin Headpiece Subdomain, in the framework of a Go-model. We have found that, in this model, the transition occurs through an initial collapsing phase driven by the starting coil configuration and a later rearrangement phase, in which secondary structures are formed and all computed paths display strong similarities. This method is completely general, does not require the prior knowledge of any reaction coordinate and represents an efficient tool to perfom ab-initio simulations of the entire folding process with available computers.

  3. USF Graduate Catalog 20142015 http://health.usf.edu/publichealth/

    E-Print Network [OSTI]

    Meyers, Steven D.

    and evaluation of programs to support healthy lifestyles; Application of technology in public health toxicology and health risk assessment, Ergonomics and occupational heat stress, Occupational data, analysis of environmental data such as air pollution, health outcome evaluation, emdical

  4. BENCHMARK DATA FOR STRUCTURAL HEALTH MONITORING Jyrki Kullaa

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    BENCHMARK DATA FOR STRUCTURAL HEALTH MONITORING Jyrki Kullaa Helsinki Metropolia University analysis is a key function in structural health monitoring (SHM). To develop algorithms for SHM, one needs. KEYWORDS : structural health monitoring, damage detection, environmental or operational effects, moving

  5. Biofuels Fuels Technology Pathway Options for Advanced Drop-in Biofuels Production

    SciTech Connect (OSTI)

    Kevin L Kenney

    2011-09-01

    Advanced drop-in hydrocarbon biofuels require biofuel alternatives for refinery products other than gasoline. Candidate biofuels must have performance characteristics equivalent to conventional petroleum-based fuels. The technology pathways for biofuel alternatives also must be plausible, sustainable (e.g., positive energy balance, environmentally benign, etc.), and demonstrate a reasonable pathway to economic viability and end-user affordability. Viable biofuels technology pathways must address feedstock production and environmental issues through to the fuel or chemical end products. Potential end products include compatible replacement fuel products (e.g., gasoline, diesel, and JP8 and JP5 jet fuel) and other petroleum products or chemicals typically produced from a barrel of crude. Considering the complexity and technology diversity of a complete biofuels supply chain, no single entity or technology provider is capable of addressing in depth all aspects of any given pathway; however, all the necessary expert entities exist. As such, we propose the assembly of a team capable of conducting an in-depth technology pathway options analysis (including sustainability indicators and complete LCA) to identify and define the domestic biofuel pathways for a Green Fleet. This team is not only capable of conducting in-depth analyses on technology pathways, but collectively they are able to trouble shoot and/or engineer solutions that would give industrial technology providers the highest potential for success. Such a team would provide the greatest possible down-side protection for high-risk advanced drop-in biofuels procurement(s).

  6. 2012 Pathways to Commercial Success: Technologies and Products...

    Energy Savers [EERE]

    2 Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program 2012 Pathways to Commercial Success: Technologies and Products Supported...

  7. 2009 Pathways to Commercial Success: Technologies and Products...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathways to Commercial Success: Technologies and Products Supported by the Hydrogen, Fuel Cells and Infrastructure Technologies Program 2009 Pathways to Commercial Success:...

  8. DOE Materials-Based Hydrogen Storage Summit: Defining Pathways...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Materials-Based Hydrogen Storage Summit: Defining Pathways for Onboard Automotive Applications DOE Materials-Based Hydrogen Storage Summit: Defining Pathways for Onboard Automotive...

  9. 2010 Pathways to Commercial Success: Technologies and Products...

    Energy Savers [EERE]

    0 Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program 2010 Pathways to Commercial Success: Technologies and Products Supported...

  10. 2014 Pathways to Commercial Success: Technologies and Products...

    Office of Environmental Management (EM)

    4 Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office 2014 Pathways to Commercial Success: Technologies and Products Supported...

  11. 2011 Pathways to Commercial Success: Technologies and Products...

    Energy Savers [EERE]

    1 Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program 2011 Pathways to Commercial Success: Technologies and Products Supported...

  12. Syngas Upgrading to Hydrocarbon Fuels Technology Pathway | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathway This technology pathway case investigates the upgrading of woody biomass derived synthesis gas (syngas) to hydrocarbon biofuels. While this specific discussion...

  13. Biological Conversion of Sugars to Hydrocarbons Technology Pathway...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathway This technology pathway case investigates the biological conversion of biomass-derived sugars to hydrocarbon biofuels, utilizing data from recent literature references and...

  14. In-Situ Catalytic Fast Pyrolysis Technology Pathway | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    needs that should be pursued for this pathway to be competitive with petroleum-derived blendstocks have been identified. In-Situ Catalytic Fast Pyrolysis Technology Pathway...

  15. Bayesian network models of biological signaling pathways

    E-Print Network [OSTI]

    Sachs, Karen, Ph. D. Massachusetts Institute of Technology

    2006-01-01

    Cells communicate with other cells, and process cues from their environment, via signaling pathways, in which extracellular cues trigger a cascade of information flow, causing signaling molecules to become chemically, ...

  16. ORISE: Statistical Analyses of Worker Health

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    appropriate methods of statistical analysis to a variety of problems in occupational health and other areas. Our expertise spans a range of capabilities essential for statistical...

  17. Pathway Controlled Penetration (PcP)

    SciTech Connect (OSTI)

    Knight, Earl E. [Los Alamos National Laboratory; Rougier, Esteban [Los Alamos National Laboratory; Zubelewicz, Aleksander [Los Alamos National Laboratory

    2012-08-29

    The technical approach employs advanced computational simulation tools to demonstrate how current assets can destroy RWK-RFI-12-0001's HDBT, a tunnel complex with two portals built into the base of a granite mountain. The granite over layer is assumed to be 60 meters thick over both portals and 80 meters over the facility's mission space. Key S&T is the completed development of a highly innovative viscoplastic fracture material model, 3D parallel gas-fracture capabilities into FDEM, and a stochastic handling of the material properties. Phase I - Develop and validate code simulation tools: (1) develop, incorporate and validate AZ-Frac material model for granite; and (2) Develop and incorporate gas-driven-fracture modeling into LANL's FDEM MUNROU code; (3) Develop and incorporate stochastic features into FDEM modeling. Phase II - Conduct PcP analysis on above HDBT: (1) Acquire HDBT design data, develop simulation model; and (2) Evaluate and select most promising defeat alternative. Phase III - Deliver code, train Service target analysts, and conduct simulations against real world HDBTs. PcP uses advanced computer simulations to enhance HDBT functional defeat efforts. Newly developed material models that account for fractural energy coupled with the finite discrete element methodology (FDEM) will provide targeting packages that will create penetration avenues for current or future lethality options. This novel computational approach requires full 3D geologic and structure characterization as well as significant high performance computing capabilities. The goal is to distinctively alter the targeting paradigm by leveraging critical DoD assets along with insitu geologic strata. In other words, assets will utilize underground rock structure to their benefit by creating rubbilization zones that will allow pathway controlled penetration.

  18. environmental health The Local Board of Health

    E-Print Network [OSTI]

    environmental health The Local Board of Health Environmental Health Primer Second Edition #12;The Local Board of Health Environmental Health Primer Second Edition Author Carrie Hribar, MA Project Director ­ Public Health Policy National Association of Local Boards of Health Editor Mark Schultz, MEd

  19. Decision analysis of polluted sites -- A fuzzy set approach

    SciTech Connect (OSTI)

    Mohamed, A.M.O.; Cote, K.

    1999-07-01

    A decision analysis based model (DAPS 1.0, Decision Analysis of Polluted Sites) has been developed to evaluate risks that polluted sites might pose to human health. Pollutants present in soils and sediments can potentially migrate from source to receptor(s), via different pathways. in the developed model, pathways are simulated via transport models (i.e., groundwater transport model, runoff-erosion model, air diffusion model, and sediment diffusion, and resuspension model in water bodies). Humans can be affected by pollutant migration through land and water use. health risks can arise from ingestion of and dermal contact with polluted water and soil, as well as through inhalation of polluted air. Quantitative estimates of risks are calculated for both carcinogenic and non-carcinogenic pollutants. Being very heterogeneous, soil and sediment systems are characterized by uncertain parameters. Concepts of fuzzy set theory have been adopted to account for uncertainty in the input parameters which are represented by fuzzy numbers. An inference model using fuzzy logic has been constructed for reasoning in the decision analysis.

  20. Health Insurance After Graduation

    E-Print Network [OSTI]

    Kammen, Daniel M.

    Health Insurance After Graduation: Individual Health Insurance in California University of California, Berkeley Student Health Insurance Office Tang Center Fall Semester 2013 #12;Health Care vs. Health Insurance Health Care is... Provision of Medical Services by ­ Private Physicians & Hospitals

  1. Beryllium-Associated Worker Registry - HPMC Occupational Health...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  2. Human Reliability Program (HRP) - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  3. Walk-In Medical Services - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    EpidemiologyHealth Data Analysis Human Reliability Program (HRP) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program...

  4. HealtH ScienceS Making a Difference froM cell to Society

    E-Print Network [OSTI]

    Kavanagh, Karen L.

    Faculty oF HealtH ScienceS Making a Difference froM cell to Society 2007-2012 report #12;1 table and Health Policy Analysis 32 Global Health 33 Social Inequities and Health 36 Occupational & Environmental Health 37 Chronic & Infectious Diseases 39 Mental Health and Addictions 41 Population & Public Health

  5. Combustion & Health 

    E-Print Network [OSTI]

    Hamilton, W.

    2012-01-01

    stream_source_info ESL-KT-12-10-18.pdf.txt stream_content_type text/plain stream_size 4107 Content-Encoding ISO-8859-1 stream_name ESL-KT-12-10-18.pdf.txt Content-Type text/plain; charset=ISO-8859-1 FFCOMBUSTION & HEALTH... Winifred J. Hamilton, PhD, SM Clear Air Through Energy Efficiency (CATEE) Galveston, TX October 9?11, 2012 FFCOMBUSTION & HEALTH FFCOMBUSTION: THE THREAT ? Biggest threat to world ecosystems (and to human health) ? Combustion of fossil fuels...

  6. Identifying Key Pathways in Multiple Cancers with Multi-omics Pathway Analysis

    E-Print Network [OSTI]

    Ng, Sam

    2015-01-01

    angiogenesis, and oncogenesis, Figure 5B. Comparison of theis an early driver of oncogenesis. Thus it is consistentbidirectional receptors in oncogenesis. Orthogonality with

  7. Identifying Key Pathways in Multiple Cancers with Multi-omics Pathway Analysis

    E-Print Network [OSTI]

    Ng, Sam

    2015-01-01

    Goiffon R.J. , Goldstein T.C. , Ng S. , et al. (2012) Whole-Benz S.C. , Goldstein T.C. , Ng S. , et al. (2011) SubtypeA.D. , Tamborero D. , Ng S. , et al. (2014) Multiplatform

  8. Ethanol Pathways in the 2050 North American Transportation Futures Study

    SciTech Connect (OSTI)

    2009-01-18

    A paper discussing the various ethanol pathways in the 2050 North American Transportation Futures Study

  9. 3.0 Modular Program Pathway 3.1 Pathway Overview

    E-Print Network [OSTI]

    JT-60 SU ARIES-RS Scale (?) Ignitor-like Compact Tok., .(+AT) LHD, W7-AS, W7-X Base Fusion ScienceDraft 7/17/98 21 3.0 Modular Program Pathway 3.1 Pathway Overview The major issues in fusion R gain that have characteristics similar to those expected in a fusion energy source, (2) the achievement

  10. Transient Pulse Formation in Jasmonate Signaling Pathway

    E-Print Network [OSTI]

    Subhasis Banerjee; Indrani Bose

    2010-03-03

    The jasmonate (JA) signaling pathway in plants is activated as defense response to a number of stresses like attacks by pests or pathogens and wounding by animals. Some recent experiments provide significant new knowledge on the molecular detail and connectivity of the pathway. The pathway has two major components in the form of feedback loops, one negative and the other positive. We construct a minimal mathematical model, incorporating the feedback loops, to study the dynamics of the JA signaling pathway. The model exhibits transient gene expression activity in the form of JA pulses in agreement with experimental observations. The dependence of the pulse amplitude, duration and peak time on the key parameters of the model is determined computationally. The deterministic and stochastic aspects of the pathway dynamics are investigated using both the full mathematical model as well as a reduced version of it. We also compare the mechanism of pulse formation with the known mechanisms of pulse generation in some bacterial and viral systems.

  11. College of Health Sciences Health Sciences Connection

    E-Print Network [OSTI]

    Barrash, Warren

    College of Health Sciences Health Sciences Connection 1 Dean's Message College of Health Sciences Health Sciences Connection February 2011 Volume IX (3) Since the last COHS newsletter, the faculty Dr. Tim Dunnagan, Dean #12;Health Sciences Connection 2 College News College of Health Sciences

  12. College of Health Sciences Health Sciences Connection

    E-Print Network [OSTI]

    Barrash, Warren

    College of Health Sciences Health Sciences Connection 1 Dean's Message College of Health Sciences Health Sciences Connection November 2010 Volume IX (2) Rationale The faculty, staff and students within the sweeping changes associated with health care reform. Health care reform represents the most significant

  13. 1-on-1 Health Coaching - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1-on-1 Health Coaching Health Education & Wellness Downloads & Patient Materials Health & Productivity Health Calculators & Logs Health Coaching Health Fairs and Screenings...

  14. AIR AND RADON PATHWAY MODELING FOR THE F AREA TANK FARM

    SciTech Connect (OSTI)

    Dixon, K.; Phifer, M.

    2010-07-30

    An air and radon pathways analysis was conducted for the F-Area Tank Farm (FTF) to estimate the flux of volatile radionuclides and radon at the ground surface due to residual waste remaining in the tanks following closure. This analysis was used as the basis to estimate the dose to the maximally exposed individual (MEI) for the air pathway per Curie (Ci) of each radionuclide remaining in the combined FTF waste tanks. For the air pathway analysis, several gaseous radionuclides were considered. These included carbon-14 (C-14), chlorine-36 (Cl-36), iodine-129 (I-129), selenium-79 (Se-79), antimony-125 (Sb-125), tin-126 (Sn-126), tritium (H-3), and technetium-99 (Tc-99). The dose to the MEI was estimated at the SRS Boundary during the 100 year institutional control period. For the 10,000 year post closure compliance period, the dose to the MEI was estimated at the 100 m compliance point. Additionally, the dose to the MEI was estimated at a seepage outcrop located 1600 m from the facility. For the radon pathway analysis, five parent radionuclides and their progeny were analyzed. These parent radionuclides included uranium-238 (U-238), plutonium-238 (Pu-238), uranium-234 (U-234), thorium-230 (Th-230), and radium-226 (Ra-226). The peak flux of radon-222 due to each parent radionuclide was estimated for the simulation period of 10,100 years.

  15. Health effects of risk-assessment categories

    SciTech Connect (OSTI)

    Kramer, C.F.; Rybicka, K.; Knutson, A.; Morris, S.C.

    1983-10-01

    Environmental and occupational health effects associated with exposures to various chemicals are a subject of increasing concern. One recently developed methodology for assessing the health impacts of various chemical compounds involves the classification of similar chemicals into risk-assessment categories (RACs). This report reviews documented human health effects for a broad range of pollutants, classified by RACs. It complements other studies that have estimated human health effects by RAC based on analysis and extrapolation of data from animal research.

  16. Corporate Analysis of DOE Safety Performance

    Broader source: Energy.gov [DOE]

    The Office of Environment, Health, Safety and Security (EHSS), Office of Analysis develops analysis tools and performance dashboards, and conducts analysis of DOE safety performance corporately and on a variety of specific environment, safety and health topics.

  17. Anticipated Survival and Health Behaviours in Older English Adults: Cross Sectional and Longitudinal Analysis of the English Longitudinal Study of Ageing

    E-Print Network [OSTI]

    Adams, Jean; Stamp, Elaine; Nettle, Daniel; Milne, Eugene M. G.; Jagger, Carol

    2015-03-23

    - style Survey. Arch Intern Med. 2010; 170(8):711–8. doi: 10.1001/archinternmed.2010.76 PMID: 20421558 2. Scarborough P, Bhatnagar P, Wickramasinghe KK, Allender S, Foster C, Rayner M. The economic bur- den of ill health due to diet, physical inactivity...

  18. interdisciplinary Glyphosate, pathways to modern diseases II

    E-Print Network [OSTI]

    Seneff, Stephanie

    rashes, depression, and nutrient deficiencies. Usually, but not always, a strict gluten-free diet caninterdisciplinary Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North

  19. Energy use by biological protein transport pathways

    E-Print Network [OSTI]

    Economou, Tassos

    Energy use by biological protein transport pathways Nathan N. Alder1 and Steven M. Theg2 1 of metabolic energy, using the free energy of ATP and GTP hydrolysis and/or a transmembrane protonmotive force provided insights into the mechanisms of energy transduction, force generation and energy use by different

  20. Syngas Upgrading to Hydrocarbon Fuels Technology Pathway

    SciTech Connect (OSTI)

    Talmadge, M.; Biddy, Mary J.; Dutta, Abhijit; Jones, Susanne B.; Meyer, Pimphan A.

    2013-03-31

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to hydrocarbon fuels to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This pathway case investigates the upgrading of biomass derived synthesis gas (‘syngas’) to hydrocarbon biofuels. While this specific discussion focuses on the conversion of syngas via a methanol intermediate to hydrocarbon blendstocks, there are a number of alternative conversion routes for production of hydrocarbons through a wide array of intermediates from syngas. Future work will also consider the variations to this pathway to determine the most economically viable and risk adverse conversion route. Technical barriers and key research needs have been identified that should be pursued for the syngas to hydrocarbon pathway to be competitive with petroleum-derived gasoline, diesel and jet range blendstocks.

  1. TRANSPORT PATHWAYS OF THE MAINE COASTAL CURRENT

    E-Print Network [OSTI]

    TRANSPORT PATHWAYS OF THE MAINE COASTAL CURRENT Monica J. Holboke and Daniel R. Lynch September 1996 Abstract The Maine Coastal Current(MCC) is initiated off the eastern coast of Maine and circuits the Gulf of Maine in a counterclockwise direction transporting various nu­ trients, biological species

  2. Disulfide-Linked Protein Folding Pathways

    E-Print Network [OSTI]

    Bardwell, James

    Disulfide-Linked Protein Folding Pathways Bharath S. Mamathambika1,3 and James C. Bardwell2,3, 1 of protein folding is difficult because it involves the identification and characterization of folding to protein folding in vitro and in vivo. 211 Click here for quick links to Annual Reviews content online

  3. --SNAPSHOT --STEPS (Sustainable Transportation Energy Pathways)

    E-Print Network [OSTI]

    California at Davis, University of

    of all types of alternative fuels and fuel uses and further the Energy Commission's goals of promoting of alternative vehicles and fuels in California, in order to help inform the Energy Commission's investment-- SNAPSHOT -- STEPS (Sustainable Transportation Energy Pathways) TECHNICAL ASSISTANCE AGREEMENT

  4. Doctor of Applied Social Research Housing Pathway

    E-Print Network [OSTI]

    Little, Tony

    DASR Doctor of Applied Social Research Housing Pathway · The programme is intended for experienced professionals whose work may require them to design, commission, evaluate or interpret research in housing process (including legislation), Scottish, UK and EU housing policy and governance structures

  5. LIFE Economics and Delivery Pathway Presentation to

    E-Print Network [OSTI]

    LIFE Economics and Delivery Pathway Presentation to National Research Council's review is necessary (but not sufficient) for economic viability Minimumforeconomics Cost and risk to buy additional systems approach is required to develop an economically viable plant design Anklam--NAS/NAE, January 29

  6. Wilton Park Conference WP674 INVESTING IN HEALTH FOR ECONOMIC GROWTH AND POVERTY REDUCTION: NEW PERSPECTIVES AND

    E-Print Network [OSTI]

    Klein, Ophir

    Wilton Park Conference WP674 INVESTING IN HEALTH FOR ECONOMIC GROWTH AND POVERTY REDUCTION: NEW IN HEALTH FOR ECONOMIC GROWTH AND POVERTY REDUCTION: NEW PERSPECTIVES AND OPPORTUNITIES 20 - 23 May 2002 health is seen as a critical pathway for addressing world poverty. At the 55th Session of the UN General

  7. In silico metabolic pathway modeling and analysis of Mycoplasma pneumoniae

    E-Print Network [OSTI]

    or microorganism. This method can be accomplished by step-by-step approach to resolve and verify the uncertainties of the metabolic model [2, 5]. Mycoplasma pneumoniae is a pathogen causing atypical pneumonia in human beings, and pathogenicity related studies have been extensively carried out [3]. Basic studies of M. pneumoniae were

  8. The Pathalyzer: a Tool for Analysis of Signal Transduction Pathways

    E-Print Network [OSTI]

    Dill, David L.

    ­scale signal trans­ duction networks. Reactions and their substrates and products are represented as transitions and places in a safe Petri net. The user can interactively specify goal states, such as activation with no significant understanding of Petri nets or any of the other concepts used in the implementation. 1

  9. The Pathalyzer: a Tool for Analysis of Signal Transduction Pathways

    E-Print Network [OSTI]

    Dill, David L.

    -scale signal trans- duction networks. Reactions and their substrates and products are represented as transitions and places in a safe Petri net. The user can interactively specify goal states, such as activation with no significant understanding of Petri nets or any of the other concepts used in the implementation. 1

  10. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production

    Fuel Cell Technologies Publication and Product Library (EERE)

    Report documenting the biological and engineering characteristics of five algal and bacterial hydrogen production systems selected by DOE and NREL for evaluation.

  11. Deduction and Analysis of the Interacting Stress Response Pathways...

    Office of Scientific and Technical Information (OSTI)

    D. vulgaris strains, and functionally analyzed those mutated genes identified in salt-adapted strains. Also, a new version of GeoChip 4.0 has been developed, which also...

  12. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production

    SciTech Connect (OSTI)

    James, B. D.; Baum, G. N.; Perez, J.; Baum, K. N.

    2009-09-01

    Report documenting the biological and engineering characteristics of five algal and bacterial hydrogen production systems selected by DOE and NREL for evaluation.

  13. Supply Chain Sustainability Analysis of Three Biofuel Pathways...

    Office of Scientific and Technical Information (OSTI)

    based on actual experimental results relative to technical targets and cost goals from design cases and includes technical, economic, and environmental criteria as available....

  14. A Bayesian analysis of the ERK signalling pathway

    E-Print Network [OSTI]

    Vyshemirsky, V.

    Vyshemirsky,V. Girolami,M. Gormand,A. Kolch,W. Department of Computing Science Technical Reports pp 1--34

  15. Analysis of Metabolic Pathways and Fluxes in a Newly Discovered...

    Office of Scientific and Technical Information (OSTI)

    a maximum ethanol yield of 0.38+-0.07 mol mol-1 more glucose. In silico flux balance modeling demonstrates that lactate and acetate production from G. thermoglucosidasius...

  16. Analysis of Metabolic Pathways and Fluxes in a Newly Discovered...

    Office of Scientific and Technical Information (OSTI)

    provided as a public service. Visit OSTI to utilize additional information resources in energy science and technology. A paper copy of this document is also available for sale to...

  17. Sample-Specific Cancer Pathway Analysis Using PARADIGM

    E-Print Network [OSTI]

    Benz, Stephen Charles

    2012-01-01

    associated with Ovarian Cancer 29 3.2.3 Di?erentiallyOvarian Cancer . . . . . . . . . . . . . . . . . . . . . .Ovarian Cancer) . . . . . . . . . . . . . . . . . . . . . .

  18. Bayesian Pathway Analysis of Cancer Microarray Data Melike Korucuoglu1

    E-Print Network [OSTI]

    by the Scientific and Technological Research Council of Turkey (TUBITAK) grant number 111E042 (HHO). The funders had

  19. Deduction and Analysis of the Interacting Stress Response Pathways of

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing BacteriaConnect Collidertransfer

  20. Deduction and Analysis of the Interacting Stress Response Pathways of

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfate Reducing BacteriaConnect CollidertransferMetal/Radionuclide-reducing Bacteria (Technical

  1. Supply Chain Sustainability Analysis of Three Biofuel Pathways (Technical

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail. (Conference)Feedback System inStatusand carbon(JournalWIMP detectionpyrolyticReport)

  2. Supply Chain Sustainability Analysis of Three Biofuel Pathways (Technical

    Office of Scientific and Technical Information (OSTI)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefieldSulfateSciTechtail. (Conference)Feedback System inStatusand carbon(JournalWIMP

  3. Hydrogen Supply: Cost Estimate for Hydrogen Pathways-Scoping Analysis.

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12,ExecutiveFinancingR Walls -Hydro-Pac Inc.,1 DOEPRODUCTIONM M a a

  4. Techno-Economic Boundary Analysis of Biological Pathways to Hydrogen

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCEDInstallers/ContractorsPhotovoltaics »Tankless WaterEnergyJanuary28-98 - MayTraditional

  5. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCEDInstallers/ContractorsPhotovoltaics »Tankless WaterEnergyJanuary28-98 - MayTraditionalProduction

  6. Introduction to Health Bachelor of Health Sciences

    E-Print Network [OSTI]

    Hickman, Mark

    Health. 2016 Introduction to Health Bachelor of Health Sciences Bachelor of Social Work Bachelor Hurunui promoting physical wellbeing and Mori and Indigenous Health in Hagley Park. Published April 2015 are available online at www.canterbury.ac.nz/regulations 18 The UC Health Graduate 20 Frequently asked questions

  7. Public Health Conferences GENERAL PUBLIC HEALTH

    E-Print Network [OSTI]

    Kamat, Vineet R.

    Public Health Conferences GENERAL PUBLIC HEALTH Michigan's Premier Public Health Conference.sph.umich.edu/scr/news_events/event.cfm?ID=2631 American Public Health Association (APHA) 140th Annual Meeting & Exposition: October 27-31, 2012 in San Francisco, CA o http://www.apha.org/meetings/AnnualMeeting/ Global Health & Innovation 2013

  8. Health Research National Institute for Health Research

    E-Print Network [OSTI]

    Diggle, Peter J.

    Embedding Health Research National Institute for Health Research Annual Report 2009/10 #12;Contents National Institute for Health Research Annual Report 2009/10 1 Foreword 2 The National Institute for Health to the NHS 40 Section 4: Strengthening health policy 54 Section 5: Changing NHS practice 64 Financial summary

  9. College of Health Sciences Health Sciences Connection

    E-Print Network [OSTI]

    Barrash, Warren

    College of Health Sciences Health Sciences Connection 1 Dean's Message College of Health Sciences Health Sciences Connection Back to School edition September 2010 Volume IX (1) Dr. Tim Dunnagan, Dean of the College of Health Sciences (COHS) at Boise State University (BSU). It is truly an honor to have

  10. Exposure information in environmental health research: Current opportunities and future directions for particulate matter, ozone, and toxic air pollutants

    E-Print Network [OSTI]

    McKone, Thomas E.

    2008-01-01

    sectional or intra-urban analysis of air pollution healthan epidemiologic analysis of air pollution health effects,

  11. counselling health promotion

    E-Print Network [OSTI]

    health and counselling services health promotion 10 Ways to get active Most people find that huff and puff stuff a few times a week and make it last for 15 minutes or more each time. students.sfu.ca/health counselling health promotion physiotherapy health clinic #12;health and counselling services health promotion

  12. Assessing Uncertainty in Spatial Exposure Models for Air Pollution Health Effects Assessment

    E-Print Network [OSTI]

    2007-01-01

    Spatial analysis of air pollution and mor- tality in Losin studies linking chronic air pollution exposure to health2006. Bayesian modeling of air pollution health effects with

  13. LWRS Fuels Pathway: Engineering Design and Fuels Pathway Initial Testing of the Hot Water Corrosion System

    SciTech Connect (OSTI)

    Dr. John Garnier; Dr. Kevin McHugh

    2012-09-01

    The Advanced LWR Nuclear Fuel Development R&D pathway performs strategic research focused on cladding designs leading to improved reactor core economics and safety margins. The research performed is to demonstrate the nuclear fuel technology advancements while satisfying safety and regulatory limits. These goals are met through rigorous testing and analysis. The nuclear fuel technology developed will assist in moving existing nuclear fuel technology to an improved level that would not be practical by industry acting independently. Strategic mission goals are to improve the scientific knowledge basis for understanding and predicting fundamental nuclear fuel and cladding performance in nuclear power plants, and to apply this information in the development of high-performance, high burn-up fuels. These will result in improved safety, cladding, integrity, and nuclear fuel cycle economics. To achieve these goals various methods for non-irradiated characterization testing of advanced cladding systems are needed. One such new test system is the Hot Water Corrosion System (HWCS) designed to develop new data for cladding performance assessment and material behavior under simulated off-normal reactor conditions. The HWCS is capable of exposing prototype rodlets to heated, high velocity water at elevated pressure for long periods of time (days, weeks, months). Water chemistry (dissolved oxygen, conductivity and pH) is continuously monitored. In addition, internal rodlet heaters inserted into cladding tubes are used to evaluate repeated thermal stressing and heat transfer characteristics of the prototype rodlets. In summary, the HWCS provides rapid ex-reactor evaluation of cladding designs in normal (flowing hot water) and off-normal (induced cladding stress), enabling engineering and manufacturing improvements to cladding designs before initiation of the more expensive and time consuming in-reactor irradiation testing.

  14. Protein signaling via type III secretion pathways in phytopathogenic bacteria

    E-Print Network [OSTI]

    109 Protein signaling via type III secretion pathways in phytopathogenic bacteria Mary Beth Mudgett secretion pathway has revealed new mechanisms by which phytopathogenic bacteria infect plants are continually exposed to a number of potentially pathogenic bacteria. Phytopathogenic bacteria, in general

  15. Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer

    E-Print Network [OSTI]

    Ooi, Chia Huey

    Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric cancer (GC) with significant relationships ...

  16. Appendix A: Office Technology Pathway Structure, Bioenergy Technologie...

    Broader source: Energy.gov (indexed) [DOE]

    A-1 Last updated: November 2014 Appendix A: Technology Pathway Structure High-level block flow diagrams for each biorefinery pathway are presented in Figures A-1 through A-5....

  17. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan Ogden and Lorraine Anderson #12;Institute of Transportation Studies University of California, Davis One SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS CHAPTER 12: KEY MEASUREMENT UNCERTAINTIES FOR BIOFUEL POLICY

  18. Structural Health Monitoring

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structural Health Monitoring Engineering Institute Structural Health Monitoring Structural Health Monitoring is the process of implementing a damage detection strategy for...

  19. Mental health in schools and public health

    E-Print Network [OSTI]

    Adelman, Howard S; Taylor, Linda

    2006-01-01

    Corporation; 1989. Public Health Reports / May–June 2006 /comes in part from the Of?ce of Adolescent Health, Maternaland Child Health Bureau (Title V, Social Security Act),

  20. Pipelines, Pathways, and Payoffs: Economic Challenges and Returns to Changing Demographics in California

    E-Print Network [OSTI]

    Stiles, Jon; Brady, Henry

    2007-01-01

    on Multiple Pathways Pipelines, Pathways, and Payoffs:Jon Stiles & Henry Brady Pipelines, Pathways, and Payoffs:of the educational pipeline to describe how students

  1. Physical Therapy Career Options Human Biology Health & Society (HBHS)

    E-Print Network [OSTI]

    Chen, Tsuhan

    65 Physical Therapy Career Options Human Biology Health & Society (HBHS) Nutritional Sciences ­ CHE-CALS) ________________________________________________________________________________________ Many NS-CHE, NS-CALS and HBHS majors consider physical therapy as a career option because, performance and rehabilitation. The pathway to a career in physical therapy for Cornell undergraduates

  2. Whole Algae Hydrothermal Liquefaction Technology Pathway

    SciTech Connect (OSTI)

    Biddy, Mary J.; Davis, Ryan; Jones, Susanne B.; Zhu, Yunhua

    2013-03-31

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to hydrocarbon fuels to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This pathway case investigates the feasibility of using whole wet microalgae as a feedstock for conversion via hydrothermal liquefaction. Technical barriers and key research needs have been assessed in order for the hydrothermal liquefaction of microalgae to be competitive with petroleum-derived gasoline, diesel and jet range blendstocks.

  3. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan://creativecommons.org/licenses/by-nc-nd/3.0/>. For information on commercial licensing, contact copyright@ucdavis.edu. #12;171 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS PART 1: INDIVIDUAL FUEL/VEHICLE PATHWAYS PART 2 Chapter 7: Comparing Land, Water

  4. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan presented in this book was drawn from the Sustainable Transportation Energy Pathways (STEPS) program.S. Environmental Protection Agency Volkswagen #12;312 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS ACKNOWLEDGEMENTS

  5. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS PART 4: POLICY AND SUSTAINABLE TRANSPORTATION Part 4: Policy and pollutants such as aerosols and black carbon. Third, more #12;250 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS

  6. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan://creativecommons.org/licenses/by-nc-nd/3.0/>. For information on commercial licensing, contact copyright@ucdavis.edu. #12;133 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS PART 1: INDIVIDUAL FUEL/VEHICLE PATHWAYS PART 2 Chapter 6: Comparing Greenhouse

  7. Systems Biology of the JAK-STAT signalling pathway

    E-Print Network [OSTI]

    Timmer, Jens

    Systems Biology of the JAK-STAT signalling pathway Jens Timmer Center for Systems Biology Center of Freiburg http://www.fdm.uni-freiburg.de/jeti/ 1 #12;Outline · Systems Biology · JAK-STAT pathway of the Epo receptor · A dynamical model for JAK-STAT pathway · Observing the unobservable · In silico biology

  8. Modeling Protein Folding Pathways Christopher Bystroff, Yu Shao

    E-Print Network [OSTI]

    Bystroff, Chris

    Modeling Protein Folding Pathways Christopher Bystroff, Yu Shao Dept of Biology Rensselaer Polytechnic Institute, Troy, NY. e-mail:{bystrc, shaoy}@rpi.edu Summary Proteins fold through a series of intermediate states called a pathway. Protein folding pathways have been modeled using either simulations

  9. Emissions pathways, climate change, and impacts on California

    E-Print Network [OSTI]

    Kammen, Daniel M.

    Emissions pathways, climate change, and impacts on California Katharine Hayhoea,b , Daniel Cayanc emission pathways we choose. Here we explore the implications of the highest and lowest Intergovern- mental Panel on Climate Change emissions pathways for climate change and associated impacts in California

  10. Assessment tool for nuclear material acquisition pathways 

    E-Print Network [OSTI]

    Ford, David Grant

    2009-05-15

    . An organization interested in a smaller required infrastructure may choose to simply obtain material that can be enriched directly, most of these pathways begin in Figure 7 with the exceptions of the EMIS path in Figure 6 and the AVLIS path in Figure 8... Produce 1 SQ of Uranium Metal Produce 1 SQ of Highly Enriched Uranium Metal Develop Basic Heavy Machinery Manufacturing Skills Develop Basic Understanding of Lasers and Optics Construct AVLIS Pilot Plant Master AVLIS Method Construct Full Scale...

  11. Pre-Health Professions Alex Gambero, Taylor Brinkman, Marshall Wallace, Program Directors

    E-Print Network [OSTI]

    Hayden, Nancy J.

    1 Pre-Health Professions Alex Gambero, Taylor Brinkman, Marshall Wallace, Program Directors OVERVIEW The objective of the Pre-Health Professions Living/Learning Community is to foster an environment for this such as the requirements, pathway, and explanation of the profession. Secondly, returning members will present

  12. Poster — Thur Eve — 51: An analysis of the effectiveness of automated pre-, post- and intra-treatment auditing of electronic health records

    SciTech Connect (OSTI)

    Joseph, A.; Seuntjens, J.; Parker, W.; Kildea, J.; Freeman, C.

    2014-08-15

    We describe development of automated, web-based, electronic health record (EHR) auditing software for use within our paperless radiation oncology clinic. By facilitating access to multiple databases within the clinic, each patient's EHR is audited prior to treatment, regularly during treatment, and post treatment. Anomalies such as missing documentation, non-compliant workflow and treatment parameters that differ significantly from the norm may be monitored, flagged and brought to the attention of clinicians. By determining historical trends using existing patient data and by comparing new patient data with the historical, we expect our software to provide a measurable improvement in the quality of radiotherapy at our centre.

  13. Pathways, Networks and Systems Medicine Conferences

    SciTech Connect (OSTI)

    Nadeau, Joseph H.

    2013-11-25

    The 6th Pathways, Networks and Systems Medicine Conference was held at the Minoa Palace Conference Center, Chania, Crete, Greece (16-21 June 2008). The Organizing Committee was composed of Joe Nadeau (CWRU, Cleveland), Rudi Balling (German Research Centre, Brauschweig), David Galas (Institute for Systems Biology, Seattle), Lee Hood (Institute for Systems Biology, Seattle), Diane Isonaka (Seattle), Fotis Kafatos (Imperial College, London), John Lambris (Univ. Pennsylvania, Philadelphia),Harris Lewin (Univ. of Indiana, Urbana-Champaign), Edison Liu (Genome Institute of Singapore, Singapore), and Shankar Subramaniam (Univ. California, San Diego). A total of 101 individuals from 21 countries participated in the conference: USA (48), Canada (5), France (5), Austria (4), Germany (3), Italy (3), UK (3), Greece (2), New Zealand (2), Singapore (2), Argentina (1), Australia (1), Cuba (1), Denmark (1), Japan (1), Mexico (1), Netherlands (1), Spain (1), Sweden (1), Switzerland (1). With respect to speakers, 29 were established faculty members and 13 were graduate students or postdoctoral fellows. With respect to gender representation, among speakers, 13 were female and 28 were male, and among all participants 43 were female and 58 were male. Program these included the following topics: Cancer Pathways and Networks (Day 1), Metabolic Disease Networks (Day 2), Day 3 ? Organs, Pathways and Stem Cells (Day 3), and Day 4 ? Inflammation, Immunity, Microbes and the Environment (Day 4). Proceedings of the Conference were not published.

  14. Introduction Health Sciences

    E-Print Network [OSTI]

    Banbara, Mutsunori

    32 Introduction Guide Entrance Life Career Inquiries Health Sciences Health Problems population, changing lifestyle habit, and the coming of globalization age. The role health sciences play, the former Department of Health Sciences of the Graduate School of Medicine, was reorganized

  15. OCCUPATIONAL HEALTH AND SAFETY

    E-Print Network [OSTI]

    OCCUPATIONAL HEALTH AND SAFETY MANAGEMENT SYSTEM Department of Occupational Health and Safety Revised December 2009 #12;Occupational Health and Safety (OHS) Management System 1. Introduction.............................................................................................................. 3 2.2 Management of Health and Safety

  16. Health Videos

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFESOpportunitiesNERSCGrid-based29HaiWhy IsHealth Benefits

  17. Global Health and Economic Impacts of Future Ozone Pollution

    E-Print Network [OSTI]

    Webster, Mort D.

    We assess the human health and economic impacts of projected 2000-2050 changes in ozone pollution using the MIT Emissions Prediction and Policy Analysis-Health Effects (EPPA-HE) model, in combination with results from the ...

  18. Structural Health Monitoring

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Current Collaborations Past Collaborations NSEC Engineering Institute Structural Health Monitoring Engineering Institute Structural Health Monitoring- Test Structures &...

  19. Structural Health Monitoring

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Current Collaborations Past Collaborations NSEC Engineering Institute Structural Health Monitoring Engineering Institute Structural Health Monitoring- Statistical Pattern...

  20. Structural Health Monitoring

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Current Collaborations Past Collaborations NSEC Engineering Institute Structural Health Monitoring Engineering Institute Structural Health Monitoring- Methodology Contact...

  1. Global Health Seminar Series

    E-Print Network [OSTI]

    Klein, Ophir

    Bay Area Global Health Seminar Series Moving beyond millennium targets in global health: The challenges of investing in health and universal health coverage Although targets can help to focus global health efforts, they can also detract attention from deeper underlying challenges in global health

  2. UNIVERSITY HEALTH CENTER UGA OCCUPATIONAL HEALTH

    E-Print Network [OSTI]

    Arnold, Jonathan

    UNIVERSITY HEALTH CENTER UGA OCCUPATIONAL HEALTH APPROVAL FOR PHYSICAL EXAMS, EYE EXAMS, LAB WORK No Faculty/Staff: Yes No UGA Employment: Full-Time Part-Time New to Occupational Health Program? Yes No E: Release of Information: I authorize the University Health Center ("UHC") at The University of Georgia

  3. Health and Counselling Services SFU Health Promotion

    E-Print Network [OSTI]

    Health and Counselling Services SFU Health Promotion A division of Student Services HEALTHY CAMPUS COMMUNITY 2 0 1 3 R E P O R T #12;Dr. Tim Rahilly Dr. Nancy Johnston FOREWORD The health and well Campus Community 2013 Report. This report highlights the work that SFU Health Promotion is undertaking

  4. Macroeconomics and Health: Investing in Health for

    E-Print Network [OSTI]

    Macroeconomics and Health: Investing in Health for Economic Development #12;Information concerning be obtained from: World Health Organization Marketing and Dissemination 1211 Geneva 27, Switzerland tel: (41 clear and strong on the central task of raising the health of the poor. I can be `realistic

  5. Duke Health Enterprise Organized Health Care Arrangement

    E-Print Network [OSTI]

    Duke Health Enterprise Organized Health Care Arrangement NOTICE OF PRIVACY PRACTICES WE ARE COMMITTED TO PROTECTING THE PRIVACY OF YOUR PROTECTED HEALTH INFORMATION. THIS NOTICE DESCRIBES HOW MEDICAL IT CAREFULLY. This notice of our privacy practices explains: 1. How we may use and disclose your health

  6. Transforming health and humanitarian Health Disaster Humanitarian

    E-Print Network [OSTI]

    Li, Mo

    Transforming health and humanitarian Health Disaster Humanitarian Systems Management Operations.humanitarian.scl.gatech.edu@HHSGATech · · · · · · · · · systems through education, outreach, and applied research 6-day Professional Certificate program in Health & Humanitarian Supply Chain Management HHS@isye.gatech.edu HHSGATech HHS Georgia Tech Annual Health

  7. Converging biochemical pathways in psychiatric disorders

    E-Print Network [OSTI]

    Soda, Takahiro

    2012-01-01

    According to the World Health Organization, neuropsychiatric diseases account for approximately one third of years lost to disability. Yet, despite this huge disease burden, there is a lack of new treatments under development: ...

  8. Funding Opportunity Announcement: Solar Market Pathways

    Broader source: Energy.gov [DOE]

    The Solar Market Pathways funding opportunity announcement (FOA) seeks to support regional, state, tribal, and locally-driven efforts to develop multi-year solar deployment plans that will help provide business certainty and establish a clear path for the next five to ten years of solar deployment. Specifically, this FOA is intended to enable replicable multi-year strategies that spur significant solar deployment, drive down solar soft costs, support local economic development efforts, and address the potential challenges arising from increased solar penetration on the electrical grid.

  9. China 2050 Pathways Calculator | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar Energy LLCLtd Jump to:Changing WorldCalifornia: EnergyRural2050 Pathways

  10. USDOE study: Human health and ecological risk assessment for produced water discharges

    SciTech Connect (OSTI)

    Meinhold, A.F.; Holtzman, S.; DePhillips, M.; Hamilton, L.D.

    1994-12-31

    Produced water generated during the production of oil and gas can contain high concentrations of radionuclides, organics and heavy metals. There are concerns about potential human health and ecological impacts from the discharge of these contaminants to the Gulf of Mexico. Data collected in the United States Department of Energy (USDOE) field study are being used in a series of human health and ecological risk assessments. These assessments will support scientifically-based regulation and risk management. This presentation: summarizes risk assessments performed for produced water discharges; describes how uncertainties in these assessments are guiding data collection efforts in the USDOE field study; and outlines ongoing risk assessment studies. In these studies, risk assessment is treated as an iterative process. An initial screening-level assessment is performed to identify important contaminants, transport and exposure pathways, and parameters. These intermediate results are used to guide data collection efforts and refinements to the analysis. At this stage in the analysis, risk is described in terms of probabilities; the uncertainties in each measured or modeled parameter are considered explicitly.

  11. Health Damages from Air Pollution in China

    E-Print Network [OSTI]

    Matus, Kira

    In China, elevated levels of urban air pollution result in substantial adverse health impacts for its large and rapidly growing urban population. An expanded version of the Emissions Prediction and Policy Analysis (EPPA), ...

  12. 1New Students Orientation Campus Health & Wellbeing Health Services

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    1New Students Orientation ­ Campus Health & Wellbeing University Health Services Campus Health & Wellbeing 2New Students Orientation ­ Campus Health & Wellbeing University Health Services (UHS) UMass (HPV, MMR, etc...) Sports Medicine 9New Students Orientation ­ Campus Health & Wellbeing UHS also

  13. COMMUNITY HEALTH NEEDS ASSESSMENT COMMUNITY HEALTH IMPROVEMENT PLAN

    E-Print Network [OSTI]

    Goldman, Steven A.

    COMMUNITY HEALTH NEEDS ASSESSMENT COMMUNITY HEALTH IMPROVEMENT PLAN FOR HOSPITAL SYSTEMS SERVING MONROE COUNTY, NEW YORK 2012 Lakeside Health System Rochester General Health System Unity Health System Memorial Hospital Developed Collaboratively with Finger Lakes Health System Agency Monroe County Department

  14. COMMUNITY HEALTH NEEDS ASSESSMENT COMMUNITY HEALTH IMPROVEMENT PLAN

    E-Print Network [OSTI]

    Goldman, Steven A.

    COMMUNITY HEALTH NEEDS ASSESSMENT COMMUNITY HEALTH IMPROVEMENT PLAN FOR HOSPITAL SYSTEMS SERVING MONROE COUNTY, NEW YORK 2013 Lakeside Health System Rochester General Health System Unity Health System Memorial Hospital Developed Collaboratively with Finger Lakes Health System Agency Monroe County Department

  15. Environment/Health/Safety (EHS): Monthly Accident Statistics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Personal Protective Equipment (PPE) Injury Review & Analysis Worker Safety and Health Program: PUB-3851 Monthly Accident Statistics Latest Accident Statistics Accident...

  16. Update of Part 61 Impacts Analysis Methodology. Methodology report. Volume 1

    SciTech Connect (OSTI)

    Oztunali, O.I.; Roles, G.W.

    1986-01-01

    Under contract to the US Nuclear Regulatory Commission, the Envirosphere Company has expanded and updated the impacts analysis methodology used during the development of the 10 CFR Part 61 rule to allow improved consideration of the costs and impacts of treatment and disposal of low-level waste that is close to or exceeds Class C concentrations. The modifications described in this report principally include: (1) an update of the low-level radioactive waste source term, (2) consideration of additional alternative disposal technologies, (3) expansion of the methodology used to calculate disposal costs, (4) consideration of an additional exposure pathway involving direct human contact with disposed waste due to a hypothetical drilling scenario, and (5) use of updated health physics analysis procedures (ICRP-30). Volume 1 of this report describes the calculational algorithms of the updated analysis methodology.

  17. USHIPUndergraduate Student Health

    E-Print Network [OSTI]

    Mease, Kenneth D.

    USHIPUndergraduate Student Health Insurance Plan WHAT IS HEALTH CARE REFORM? Health Care Reform,includingcoveragestandards,pricingstandards,andanindividualmandate.Theindividual mandate is a requirement that every U.S. citizen have qualifying health insurance coverage or pay a monetary penalty (beginning in 2014). Please note that student health insurance plans are considered

  18. Health sciences at Manchester

    E-Print Network [OSTI]

    Higham, Nicholas J.

    Health sciences at Manchester a time of change and growth Institute of Health Sciences January 2010 #12;The Institute of Health Sciences exists to improve health and healthcare practice through high quality health sciences research in Manchester. It is a collaborative endeavour involving schools

  19. The Local Board of Health Environmental Health Primer

    E-Print Network [OSTI]

    The Local Board of Health Environmental Health Primer Risk Assessment Factsheet environmental health Background · Localpublichealthprotectionrequiresidentifyingandprioritizingneedsthroughrisk.Environmentalandhealthdepartmentofficialsshould developcommunity-specificcriteriaforconductingtheriskmanagementphaseof hazardandriskreduction. Board of Health

  20. Environment, Safety, and Health Reporting

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-08-19

    To ensure timely collection, reporting, analysis, and dissemination of information on environment, safety, and health issues as required by law or regulations or as needed to ensure that the Department of Energy (DOE) and National Nuclear Security Administration (NNSA) are kept fully informed on a timely basis about events that could adversely affect the health and safety of the public or the workers, the environment, the intended purpose of DOE facilities, or the credibility of the Department. Cancels DOE O 210.1, DOE O 231.1, and DOE O 232.1A. Canceled by DOE O 232.2.

  1. Weight Management Program - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Program Health Education & Wellness Downloads & Patient Materials Health & Productivity Health Calculators & Logs Health Coaching Health Fairs and Screenings Interactive Exercises...

  2. Body Mass Index - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health Education & Wellness > Health Calculators & Logs > Body Mass Index Health Education & Wellness Downloads & Patient Materials Health & Productivity Health Calculators & Logs...

  3. Bioenergy Technologies Office Conversion R&D Pathway: Whole Algae...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Whole Algae Hydrothermal Liquefaction Bioenergy Technologies Office Conversion R&D Pathway: Whole Algae Hydrothermal Liquefaction Whole algae hydrothermal liquefaction is one of...

  4. Systems biology of endothelial mechano-activated pathways

    E-Print Network [OSTI]

    Koo, Andrew Jia-An

    2013-01-01

    Multiple signaling pathways are employed by endothelial cells to differentially respond to distinct hemodynamic environments and acquire functional phenotypes, including regulation of inflammation, angiogenesis, blood ...

  5. Identification of Low Emissions Agricultural Pathways and Priorities...

    Open Energy Info (EERE)

    Identification of Low Emissions Agricultural Pathways and Priorities for Mitigation in Agricultural Landscapes using Integrated Assessment Modeling and Scenarios Jump to:...

  6. Pathways of Epoxyeicosatrienoic Acid Metabolism in Endothelial Cells

    E-Print Network [OSTI]

    Hammock, Bruce D.

    Morisseau , David A. Thompson , Bruce D. Hammock , and Arthur A. Spector§ From the Departments, relatively little is known about the biochemical pathways that mediate EET uptake and metabolism

  7. Method to determine transcriptional regulation pathways in organisms...

    Office of Scientific and Technical Information (OSTI)

    Title: Method to determine transcriptional regulation pathways in organisms The invention relates to computer-implemented methods and systems for identifying regulatory...

  8. Protein Bridges DNA Base and Nucleotide Excision Repair Pathways

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Bridges DNA Base and Nucleotide Excision Repair Pathways Print Alkyltransferase proteins (AGT) protect cells from the biological effects of DNA damage caused by the addition...

  9. Bioenergy Technologies Office R&D Pathways: Fast Pyrolysis and...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fast Pyrolysis and Hydroprocessing Bioenergy Technologies Office R&D Pathways: Fast Pyrolysis and Hydroprocessing In fast pyrolysis and hydrotreating, biomass is rapidly heated in...

  10. Hydrochemical and isotopic effects associated with petroleum fuel biodegradation pathways

    E-Print Network [OSTI]

    Sheffield, University of

    Hydrochemical and isotopic effects associated with petroleum fuel biodegradation pathways attenuation capacity in this dual- porosity aquifer. D 2005 Published by Elsevier B.V. Keywords: MTBE; BTEX

  11. California Baseline Energy Demands to 2050 for Advanced Energy Pathways

    E-Print Network [OSTI]

    McCarthy, Ryan; Yang, Christopher; Ogden, Joan M.

    2008-01-01

    Dryer WH - Clothes Washer Clothes Washer WH - DishwasherDishwasher Water Heating Figure 7 Breakdown of residentialUEC Water Heating (WH) Dishwasher Advanced Energy Pathways -

  12. Catalytic Upgrading of Sugars to Hydrocarbons Technology Pathway...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    for the catalytic conversion of sugars pathway to be competitive with petroleum-derived gasoline-, diesel-, and jet-range hydrocarbon blendstocks have been identified....

  13. Rural Health Association

    E-Print Network [OSTI]

    Maxwell, Bruce D.

    Montana Rural Health Association Phone: 406-994-6004 Fax: 406-994-5653 E-mail: MRHA 170520 Bozeman, Montana 59717-0520 Montana Rural Health Association Membershipdesignation.Membershipisrenewedonan annualbasis.PleasemakecheckspayabletoMontanaRuralHealth

  14. Ergonomics - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health Education & Wellness > Downloads & Patient Materials > Ergonomics Health Education & Wellness Downloads & Patient Materials Ergonomics Fitness & Exercise Men's Health...

  15. Utilization Analysis Page 1 UTILIZATION ANALYSIS

    E-Print Network [OSTI]

    Oliver, Douglas L.

    Utilization Analysis Page 1 UTILIZATION ANALYSIS Section 46a-68-40 and HIRING/PROMOTION GOALS utilized in the Health Center's workforce, the numbers of protected classes in the workforce must conducted for each occupational category and position classification. The Utilization Analysis was performed

  16. National Institutes of Health Public Health Service

    E-Print Network [OSTI]

    Ungerleider, Leslie G.

    of Acquisition and Logistics Management Subject: OAMP Policy Letter 2011-1, Announcement of Contract AwardsNational Institutes of Health Public Health Service Bethesda, Maryland 20892 DEPARTMENT OF HEALTH: Acquisition Management Committee GS-1102-ListServe From: Head of the Contracting Activity and Director, Office

  17. Multistage reaction pathways in detonating high explosives

    SciTech Connect (OSTI)

    Li, Ying; Kalia, Rajiv K.; Nakano, Aiichiro; Nomura, Ken-ichi; Vashishta, Priya

    2014-11-17

    Atomistic mechanisms underlying the reaction time and intermediate reaction products of detonating high explosives far from equilibrium have been elusive. This is because detonation is one of the hardest multiscale physics problems, in which diverse length and time scales play important roles. Here, large spatiotemporal-scale reactive molecular dynamics simulations validated by quantum molecular dynamics simulations reveal a two-stage reaction mechanism during the detonation of cyclotrimethylenetrinitramine crystal. Rapid production of N{sub 2} and H{sub 2}O within ?10 ps is followed by delayed production of CO molecules beyond ns. We found that further decomposition towards the final products is inhibited by the formation of large metastable carbon- and oxygen-rich clusters with fractal geometry. In addition, we found distinct unimolecular and intermolecular reaction pathways, respectively, for the rapid N{sub 2} and H{sub 2}O productions.

  18. Addressing Genetics Delivering Health

    E-Print Network [OSTI]

    Rambaut, Andrew

    century in the Human Genome Project (HGP) underlined recognition throughout research and clinical the HGP, however, are challenging these boundaries and health professionals throughout the health service

  19. Biosecurity and Health

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biosecurity and Health Biosecurity and Health Los Alamos scientists are developing science and technology designed to battle pathogens responsible for causing disease epidemics,...

  20. ORISE: Public Health Communication

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Communication Public Health Communication The Oak Ridge Institute for Science and Education (ORISE) assists government agencies and organizations in addressing public health...

  1. ORISE: Health physics services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health physics services Nuclear power plant The Oak Ridge Institute for Science and Education (ORISE) offers comprehensive health physics services in a number of technical areas...

  2. Structural Health Monitoring

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structural Health Monitoring Engineering Institute Structural Health Monitoring- The Los Alamos Approach Contact Institute Director Charles Farrar (505) 663-5330 Email UCSD EI...

  3. ORISE: Public Health Preparedness

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Preparedness Public Health Preparedness The Oak Ridge Institute for Science and Education (ORISE) recognizes that public health events will largely be managed at the local level,...

  4. ORISE: Health Disparity Interventions

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Disparity Interventions Public health theory and practice suggests that risky health behaviors can be altered through interventions that organize and educate communities, screen...

  5. Environment, Safety and Health Reporting

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-01-01

    To ensure timely collection, reporting, analysis, and dissemination of information on environment, safety, and health issues as required by law or regulations or as needed to ensure that the Department of Energy (DOE) and National Nuclear Security Administration are kept fully informed on a timely basis about events that could adversely affect the health and safety of the public or the workers, the environment, the intended purpose of DOE facilities, or the credibility of the Department. Cancels DOE O 210.1, DOE O 231.1, DOE O 232.1A. Canceled by DOE O 231.1B. DOE O 231.1B cancels all portions pertaining to environment, safety, and health reporting. Occurrence reporting and processing of operations information provisions remain in effect until January 1, 2012.

  6. Hawaii Clean Energy Initiative Scenario Analysis

    Office of Energy Efficiency and Renewable Energy (EERE)

    Analysis of potential policy options to help the state reach the 70% Hawaii Clean Energy Initiative (HCEI) goal, including possible pathways to attain the goal based on currently available technology.

  7. Structural Analysis of Combustion Models

    E-Print Network [OSTI]

    Tóth, J; Zsély, I

    2013-01-01

    Using ReactionKinetics, a Mathematica based package a few dozen detailed models for combustion of hydrogen, carbon monoxide and methanol are investigated. Essential structural characteristics are pulled out, and similarities and differences of the mechanisms are highlighted. These investigations can be used before or parallel with usual numerical investigations, such as pathway analysis, sensitivity analysis, parameter estimation, or simulation.

  8. Dust resuspension as a contaminant source and transport pathway

    SciTech Connect (OSTI)

    Loosmore, G.A,; Hunt, J.R.

    1999-07-01

    Numerous environmental contaminants sorb to dust particles or exist as particles, including metals, hydrophobic organic compounds, asbestos, pollens, and microbial pathogens. Wind resuspension of dust and other particulate matter provides a dust source for the atmosphere and a contaminant transport pathway. Not only do these materials pose a risk to human health, but also, resuspended dust particles are believed to play a role in global climate change and chemical reactions in the atmosphere. The conditions under which contaminated sites are vulnerable to wind resuspension are not generally known, as the basic physics of the problem are poorly understood. Field data show tremendous variability. Conventional dust flux models assume that dust resuspension occurs only for high winds and then only temporarily, with a transient dust flux occurring only when the bed is first exposed to the high wind. The surface is then assumed to stabilize such that no further dust moves until the surface is disturbed or a higher wind occurs. Recent wind tunnel experiments demonstrate that surfaces yield continuous steady dust fluxes under steady wind conditions well beyond the initial high transient flux, even when no erosion is visible and the velocity is below the predicted threshold velocity for movement. This average steady-state dust flux increases with average wind speed. Ongoing work is investigating the influence of air relative humidity on these processes. Contaminant resuspension models capture trends only and fail to predict sporadic high flux events that may control doses. Successful modeling of contaminant resuspension will depend on development of better dust flux predictions. Risk analyses require better predictive modeling, necessitating a deeper understanding of the underlying phenomena.

  9. Coarsely resolved topography along protein folding pathways Ariel Fernandez

    E-Print Network [OSTI]

    Berry, R. Stephen

    Coarsely resolved topography along protein folding pathways Ariel Ferna´ndez Instituto de Matema . The topography is represented as a sequence of minima and effective saddle points. The dominant folding pathway. Initially misfolded states form and dismantle revealing no definite pattern in the topography and exhibiting

  10. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan of the fuels we consider #12;122 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS CHAPTER 5: COMPARING INFRASTRUCTURE://creativecommons.org/licenses/by-nc-nd/3.0/>. For information on commercial licensing, contact copyright@ucdavis.edu. #12;121 SUSTAINABLE

  11. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan. #12;188 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS PART 3: SCENARIOS FOR A LOW-CARBON TRANSPORTATION://creativecommons.org/licenses/by-nc-nd/3.0/>. For information on commercial licensing, contact copyright@ucdavis.edu. #12;187 SUSTAINABLE

  12. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan scenario. #12;210 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS CHAPTER 9: TRANSITION SCENARIOS FOR THE U://creativecommons.org/licenses/by-nc-nd/3.0/>. For information on commercial licensing, contact copyright@ucdavis.edu. #12;209 SUSTAINABLE

  13. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan, batteries, and ultracapacitors. Andrew #12;316 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS AUTHORS://creativecommons.org/licenses/by-nc-nd/3.0/>. For information on commercial licensing, contact copyright@ucdavis.edu. #12;315 SUSTAINABLE

  14. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan their feedstocks displaces food crops. #12;298 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS CONCLUSION: KEY FINDINGS. · Biofuels can make limited but significant contributions to a sustainable transportation energy supply

  15. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan://creativecommons.org/licenses/by-nc-nd/3.0/>. For information on commercial licensing, contact copyright@ucdavis.edu. #12;1 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS ACKNOWLEDGEMENTS Introduction: Imagining the Future of Transportation We stand

  16. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan by 2030, even though transportation accounts for #12;235 PART 3 SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS://creativecommons.org/licenses/by-nc-nd/3.0/>. For information on commercial licensing, contact copyright@ucdavis.edu. #12;234 SUSTAINABLE

  17. Quantifying environmental adaptation of metabolic pathways in metagenomics

    E-Print Network [OSTI]

    Saleska, Scott

    Quantifying environmental adaptation of metabolic pathways in metagenomics Tara A. Gianoulisa,1 processes is not well under- stood. Thus, a major challenge is how the usage of particular pathways, somewhat simplified classes (e.g., terrestrial vs. marine), and searched for obvious metabolic differences

  18. HIGH SCHOOL PHYSICS PATHWAY: TEACHERS HELPING TEACHERS THROUGH SYNTHETIC INTERVIEWS*

    E-Print Network [OSTI]

    , physics pedagogy, physics education 1. INTRODUCTION Physics Teaching Web Advisory (Pathway) is a researchHIGH SCHOOL PHYSICS PATHWAY: TEACHERS HELPING TEACHERS THROUGH SYNTHETIC INTERVIEWS* *Published the iterative development of a dynamic web environment for exploring physics pedagogy: the Physics Teaching Web

  19. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan Ogden and Lorraine Anderson #12;Institute of Transportation Studies University of California, Davis One TRANSPORTATION ENERGY PATHWAYS CHAPTER 4: COMPARING FUEL ECONOMIES AND COSTS OF ADVANCED VS. CONVENTIONAL

  20. SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers

    E-Print Network [OSTI]

    California at Davis, University of

    SUSTAINABLE TRANSPORTATION ENERGY PATHWAYS A Research Summary for Decision Makers Edited by Joan Ogden and Lorraine Anderson #12;Institute of Transportation Studies University of California, Davis One TRANSPORTATION ENERGY PATHWAYS CHAPTER 8: SCENARIOS FOR DEEP REDUCTIONS IN GREENHOUSE GAS EMISSIONS PART 3

  1. Pathways for Ethanol Dehydrogenation and Dehydration Catalyzed by Ceria (111) and (100) Surfaces

    SciTech Connect (OSTI)

    Beste, Ariana; Overbury, Steven {Steve} H

    2015-01-01

    We have performed computations to better understand how surface structure affects selectivity in dehydrogenation and dehydration reactions of alcohols. Ethanol reactions on the (111) and (100) ceria surfaces were studied starting from the dominant surface species, ethoxy. We used DFT (PBE+U) to explore reaction pathways leading to ethylene and acetaldehyde and calculated estimates of rate constants employing transition state theory. To assess pathway contributions, we carried out kinetic analysis. Our results show that intermediate and transition state structures are stabilized on the (100) surface compared to the (111) surface. Formation of acetaldehyde over ethylene is kinetically and thermodynamically preferred on both surfaces. Our results are consistent with temperature programmed surface reaction and steady-state experiments, where acetaldehyde was found as the main product and evidence was presented that ethylene formation at higher temperature originates from changes in adsorbate and surface structure.

  2. environmental health Understanding Concentrated

    E-Print Network [OSTI]

    environmental health Understanding Concentrated Animal Feeding Operations and Their Impact of Health Editor Mark Schultz, MEd Grants Administrator/Technical Writer National Association of Local Boards of Health ©2010 National Association of Local Boards of Health 1840 East Gypsy Lane Road Bowling

  3. HEALTH SCIENCES POSTGRADUATE

    E-Print Network [OSTI]

    2013 HEALTH SCIENCES POSTGRADUATE RESEARCH OPPORTUNITIES #12;Welcome to the Curtin Health Innovation Research Institute The Curtin Health Innovation Research Institute (CHIRI) aims to facilitate high-quality translational health research in a number of key areas including Ageing and Dementia, Prevention and Management

  4. Counselling HEALTH & COUNSELLING

    E-Print Network [OSTI]

    Counselling HEALTH & COUNSELLING SERVICES Counselling 778.782.4615 - Burnaby intake@sfu.ca 778.782.5200 - Vancouver 778.782.8022 - Surrey surrey_counsellor@sfu.ca Health Clinic 778.783.4615 - Burnaby 778.782.5200 - Vancouver Health Promotion 778.782.4674 Health & Counselling Services, SFU - 8888 University Drive, MBC 0164

  5. ENVIRONMENTAL, HEALTH AND SAFETY

    E-Print Network [OSTI]

    California at Davis, University of

    ENVIRONMENTAL, HEALTH AND SAFETY PROGRAMS SPRING 2012 Including: Free Information Session New Program in Health and Safety CONTINUING AND PROFESSIONAL EDUCATION #12;2 Our Health and Safety Programs Workplace Health and Safety Certificate Program For every dollar invested in workplace safety, organizations

  6. Environmental Public Health Tracking

    E-Print Network [OSTI]

    Environmental Public Health Tracking Network VISION Version 1.0 10/20/2004 This document has been for Disease Control and Prevention ­ Department of Health and Human Services #12;Environmental Public Health the features that will be proposed to stakeholders to support environmental public health tracking nationwide

  7. STUDENT HEALTH MEDICAL SERVICES

    E-Print Network [OSTI]

    Huang, Haiying

    Ver 2.0 09/2012 ANNEX H STUDENT HEALTH & MEDICAL SERVICES #12;Ver 2.0 09/2012 H-i APPROVAL & IMPLEMENTATION Annex H Student Health & Medical Services This emergency management plan is hereby approved. ______________________________ ________________________ Robert Blum Date Director of Health Services Marie Bannister Date Director of Mental Health Services

  8. OCCUPATIONAL SAFETY and HEALTH

    E-Print Network [OSTI]

    MARYLAND OCCUPATIONAL SAFETY and HEALTH ACT safety and health protection on the job STATE OCCUPATIONAL SAFETY AND HEALTH STANDARDS, AND OTHER APPLICABLE REGULATIONS MAY BE OBTAINED FROM and Health Administration, The Curtis Center, Suite 740 West, 170 S. Independence Mall West, Philadelphia, PA

  9. Cyclone-cyclone Interactions through the Ocean Pathway

    SciTech Connect (OSTI)

    Balaguru, Karthik; Taraphdar, Sourav; Leung, Lai-Yung R.; Foltz, Gregory R.; Knaff, John A.

    2014-10-16

    The intense SST (Sea Surface Temperature) cooling caused by hurricane-induced mixing is restored at timescales on the order of weeks(1) and thus may persist long enough to influence a later hurricane passing over it. Though many studies have evaluated the effects of SST cool-ing induced by a hurricane on its own intensification(2, 3), none has looked at its effect on later storms. Using an analysis of observations and numerical model simulations, we demonstrate that hurricanes may influence the intensity of later hurricanes that pass over their linger-ing wakes. On average, when hurricanes encounter cold wakes, they experience SSTs that are ~0.4oC lower than when they do not encounter wakes and consequently decay(intensify) at a rate that is nearly three times faster(slower). In the region of warm SSTs (* 26.5oC) where the most intense and damaging hurricanes tend to occur, the percentage of hurricanes that encounter lingering cold wakes increases with hurricane frequency and was found to be as high as 40%. Furthermore, we estimate that the cumulative power dissipated(4) by the most energetic hurricanes has been reduced by as much as ~7% in a season through this effect. As the debate on changes in Atlantic hurricane activity associated with global warming(5) continues, the negative feedback between hurricane frequency and intensity resulting from hurricane-hurricane interactions through the ocean pathway deserves attention.

  10. The Local Board of Health Environmental Health Primer

    E-Print Network [OSTI]

    The Local Board of Health Environmental Health Primer Vector Control Factsheet environmental health,bioterroristactivitiessupportedby hostilegovernmentsandindividuals,andadecreaseinvectorcontrolprograms becauseofbudgetshortages. Board of Health ActionsIntegratedPestManagementisbeingusedforvectorcontrol. · Communicateriskstothecommunityintheeventofavector-relatedemergency. Resources for Continuing Education · AssociationofStateandTerritorialHealth

  11. Determine metrics and set targets for soil quality on agriculture residue and energy crop pathways

    SciTech Connect (OSTI)

    Ian Bonner; David Muth

    2013-09-01

    There are three objectives for this project: 1) support OBP in meeting MYPP stated performance goals for the Sustainability Platform, 2) develop integrated feedstock production system designs that increase total productivity of the land, decrease delivered feedstock cost to the conversion facilities, and increase environmental performance of the production system, and 3) deliver to the bioenergy community robust datasets and flexible analysis tools for establishing sustainable and viable use of agricultural residues and dedicated energy crops. The key project outcome to date has been the development and deployment of a sustainable agricultural residue removal decision support framework. The modeling framework has been used to produce a revised national assessment of sustainable residue removal potential. The national assessment datasets are being used to update national resource assessment supply curves using POLYSIS. The residue removal modeling framework has also been enhanced to support high fidelity sub-field scale sustainable removal analyses. The framework has been deployed through a web application and a mobile application. The mobile application is being used extensively in the field with industry, research, and USDA NRCS partners to support and validate sustainable residue removal decisions. The results detailed in this report have set targets for increasing soil sustainability by focusing on primary soil quality indicators (total organic carbon and erosion) in two agricultural residue management pathways and a dedicated energy crop pathway. The two residue pathway targets were set to, 1) increase residue removal by 50% while maintaining soil quality, and 2) increase soil quality by 5% as measured by Soil Management Assessment Framework indicators. The energy crop pathway was set to increase soil quality by 10% using these same indicators. To demonstrate the feasibility and impact of each of these targets, seven case studies spanning the US are presented. The analysis has shown that the feedstock production systems are capable of simultaneously increasing productivity and soil sustainability.

  12. Understanding Contaminant Transport Pathways at Rocky Flats - A Basis for the Remediation Strategy

    SciTech Connect (OSTI)

    Paton, Ian

    2008-01-15

    The Rocky Flats Environmental Technology Site (RFETS) is a Department of Energy facility located approximately 16 miles northwest of Denver, Colorado. Processing and fabrication of nuclear weapons components occurred at Rocky Flats from 1952 through 1989. Operations at the Site included the use of several radionuclides, including plutonium-239/240 (Pu), americium-241 (Am), and various uranium (U) isotopes, as well as several types of chlorinated solvents. The historic operations resulted in legacy contamination, including contaminated facilities, process waste lines, buried wastes and surface soil contamination. Decontamination and removal of buildings at the site was completed in late 2005, culminating more than ten years of active environmental remediation work. The Corrective Action Decision/Record of Decision was subsequently approved in 2006, signifying regulatory approval and closure of the site. The use of RFETS as a National Wildlife Refuge is scheduled to be in full operation by 2012. To develop a plan for remediating different types of radionuclide contaminants present in the RFETS environment required understanding the different environmental transport pathways for the various actinides. Developing this understanding was the primary objective of the Actinide Migration Evaluation (AME) project. Findings from the AME studies were used in the development of RFETS remediation strategies. The AME project focused on issues of actinide behavior and mobility in surface water, groundwater, air, soil and biota at RFETS. For the purposes of the AME studies, actinide elements addressed included Pu, Am, and U. The AME program, funded by DOE, brought together personnel with a broad range of relevant expertise in technical investigations. The AME advisory panel identified research investigations and approaches that could be used to solve issues related to actinide migration at the Site. An initial step of the AME was to develop a conceptual model to provide a qualitative description of the relationships among potential actinide sources and transport pathways at RFETS. One conceptual model was developed specifically for plutonium and americium, because of their similar geochemical and transport properties. A separate model was developed for uranium because of its different properties and mobility in the environment. These conceptual models were guidelines for quantitative analyses described in the RFETS Pathway Analysis Report, which used existing data from the literature as well as site-specific analyses, including field, laboratory and modeling studies to provide quantitative estimates of actinide migration in the RFETS environment. For pathways where more than one method was used to estimate offsite loads for a specific pathway, the method yielding the highest estimated off-site was used for comparison purposes. For all actinides studied, for pre-remediation conditions, air and surface water were identified to be the dominant transport mechanisms. The estimated annual airborne plutonium-239/240 load transported off site exceeded the surface water load by roughly a factor of 40. However, despite being the largest transport pathway, airborne radionuclide concentrations at the monitoring location with the highest measurements during the period studied were less than two percent of the allowable 10 milli-rem standard governing DOE facilities. Estimated actinide loads for other pathways were much less. Shallow groundwater was approximately two orders of magnitude lower, or 1/100 of the load conveyed in surface water. The estimated biological pathway load for plutonium was approximately five orders of magnitude less, or 1/100,000, of the load estimated for surface-water. The pathway analysis results were taken into consideration during subsequent remediation activities that occurred at the site. For example, when the 903 Pad area was remediated to address elevated concentrations of Pu and Am in the surface soil, portable tent structures were constructed to prevent wind and water erosion from occurring while remediation activitie

  13. IN SICKNESS AND IN HEALTH

    E-Print Network [OSTI]

    Hill, Wendell T.

    IN SICKNESS AND IN HEALTH #12;The UHC Cares for YOU! #12;#12;ABOUTUS Location;HERE'S ONLY SOME OF WHAT WE CAN DO FORYOU! Health Clinic Health Health Health

  14. Occupational Health Services - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    exercise physiology and work conditioning, monitored care and case management, fitness for duty evaluations, health education and wellness promotion, infection control,...

  15. Graduate Certificate in Global Health Fact Sheet College of Public Health GRADUATE EDUCATION IN GLOBAL HEALTH

    E-Print Network [OSTI]

    Arnold, Jonathan

    Graduate Certificate in Global Health Fact Sheet · College of Public Health GRADUATE EDUCATION IN GLOBAL HEALTH Graduate Certificate in Global Health A UGA Graduate Program What is Global Health? Global health applies public health principles to solutions of health problems that transcend national

  16. Health assessment for Northwest Transformer, Salvage Yard, Everson, Whatcom County, Washington, Region 10. CERCLIS No. WAD980833974. Final report

    SciTech Connect (OSTI)

    Not Available

    1989-04-14

    The Northwest Transformer Salvage Yard is a National Priorities List (NPL) Site located in Whatcom County, Washington, approximately two miles south of the town of Everson, Washington. Between 1958-1985, the site served as a storage and refurbishing area for electrical transformers, capacitors, and other electrical equipment. An Immediate Removal Action was performed at the site in 1985, and included the excavation and removal of on-site contaminated soils, liquids, and electrical equipment. Subsequent sampling and analysis of on-site and off-site soils and groundwater revealed polychlorinated biphenyls (PCBs), chlorinated dibenzo-p-dioxins, and chlorinated dibenzofurans. Identified pathways for the migration of site-associated contaminants include those associated with groundwater, surface water, soil, and bioaccumulation. Potential pathways for human exposure to site contaminants include ingestion of contaminated groundwater, soils, or foodchain entities, inhalation of fugitive dusts, and dermal contact with contaminated groundwater, surface water, soil, or wood from an on-site building. Under current conditions the site poses a potential threat to human health in the event of unauthorized site entry, or the ingestion of contaminated groundwater.

  17. Associations of blood lead, cadmium, and mercury with estimated glomerular filtration rate in the Korean general population: Analysis of 2008-2010 Korean National Health and Nutrition Examination Survey data

    SciTech Connect (OSTI)

    Kim, Yangho [Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (Korea, Republic of)] [Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (Korea, Republic of); Lee, Byung-Kook, E-mail: bklee@sch.ac.kr [Institute of Environmental and Occupational Medicine, Soonchunhyang University 646 Eupnae-ri, Shinchang-myun, Asan-si, Choongnam 336-745 (Korea, Republic of)] [Institute of Environmental and Occupational Medicine, Soonchunhyang University 646 Eupnae-ri, Shinchang-myun, Asan-si, Choongnam 336-745 (Korea, Republic of)

    2012-10-15

    Introduction: The objective of this study was to evaluate associations between blood lead, cadmium, and mercury levels with estimated glomerular filtration rate in a general population of South Korean adults. Methods: This was a cross-sectional study based on data obtained in the Korean National Health and Nutrition Examination Survey (KNHANES) (2008-2010). The final analytical sample consisted of 5924 participants. Estimated glomerular filtration rate (eGFR) was calculated using the MDRD Study equation as an indicator of glomerular function. Results: In multiple linear regression analysis of log2-transformed blood lead as a continuous variable on eGFR, after adjusting for covariates including cadmium and mercury, the difference in eGFR levels associated with doubling of blood lead were -2.624 mL/min per 1.73 m Superscript-Two (95% CI: -3.803 to -1.445). In multiple linear regression analysis using quartiles of blood lead as the independent variable, the difference in eGFR levels comparing participants in the highest versus the lowest quartiles of blood lead was -3.835 mL/min per 1.73 m Superscript-Two (95% CI: -5.730 to -1.939). In a multiple linear regression analysis using blood cadmium and mercury, as continuous or categorical variables, as independent variables, neither metal was a significant predictor of eGFR. Odds ratios (ORs) and 95% CI values for reduced eGFR calculated for log2-transformed blood metals and quartiles of the three metals showed similar trends after adjustment for covariates. Discussion: In this large, representative sample of South Korean adults, elevated blood lead level was consistently associated with lower eGFR levels and with the prevalence of reduced eGFR even in blood lead levels below 10 {mu}g/dL. In conclusion, elevated blood lead level was associated with lower eGFR in a Korean general population, supporting the role of lead as a risk factor for chronic kidney disease.

  18. Health Sciences Center Department of Internal Medicine Employee Health Promotion Program Health Care Provider Report

    E-Print Network [OSTI]

    New Mexico, University of

    Health Sciences Center Department of Internal Medicine Employee Health Promotion Program Health Care Provider Report Dear Health Care Provider: Your patient, ______________________________, has applied for enrollment in a fitness program sponsored by the University of New Mexico, Employee Health

  19. AIR AND RADON PATHWAY MODELING FOR THE F-AREA TANK FARM

    SciTech Connect (OSTI)

    Dixon, K; Mark Phifer, M

    2007-09-17

    The F-Area Tank Farm (FTF) is located within F-Area in the General Separations Area (GSA) of the Savannah River Site (SRS) as seen in Figure 1. The GSA contains the F and H Area Separations Facilities, the S-Area Defense Waste Processing Facility, the Z-Area Saltstone Facility, and the E-Area Low-Level Waste Disposal Facilities. The FTF is a nearly rectangular shaped area and comprises approximately 20 acres, which is bounded by SRS coordinates N 76,604.5 to N 77,560.0 and E 52,435.0 to E 53,369.0. SRS is in the process of preparing a Performance Assessment (PA) to support FTF closure. As part of the PA process, an analysis was conducted to evaluate the potential magnitude of gaseous release of radionuclides from the FTF over the 100-year institutional control period and 10,000-year post-closure compliance period. Specifically, an air and radon pathways analysis has been conducted to estimate the flux of volatile radionuclides and radon at the ground surface due to residual waste remaining in the tanks following closure. This analysis was used as the basis to estimate the dose to the maximally exposed individual (MEI) for the air pathway per Curie (Ci) of each radionuclide remaining in the combined FTF waste tanks. For the air pathway analysis, several gaseous radionuclides were considered. These included carbon-14 (C-14), chlorine-36 (Cl-36), iodine-129 (I-129), selenium-79 (Se-79), antimony-125 (Sb-125), tin-126 (Sn-126), tritium (H-3), and technetium-99 (Tc-99). The dose to the MEI was estimated at the SRS Boundary during the 100 year institutional control period. For the 10,000 year post closure compliance period, the dose to the MEI was estimated at the 100 m compliance point. For the radon pathway analysis, five parent radionuclides and their progeny were analyzed. These parent radionuclides included uranium-238 (U-238), plutonium-238 (Pu-238), uranium-234 (U-234), thorium-230 (Th-230), and radium-226 (Ra-226). The peak flux of radon-222 due to each parent radionuclide was estimated for the simulation period of 10,100 years.

  20. The Local Board of Health Environmental Health Primer

    E-Print Network [OSTI]

    The Local Board of Health Environmental Health Primer Air Quality Factsheet environmental health. · Indoorairqualityatspecializedplaces,suchasschoolsorindoorpools,shouldbe monitoredaswell. Board of Health ActionsProtectionAgency.IndoorAirQuality.Availableatwww.epa.gov/iaq/ · NationalAssociationofLocalBoardsofHealth.(2011).AirQuality.InThe Local Board of Health Environmental Health

  1. Principles of Population Health Science Population Health 795

    E-Print Network [OSTI]

    Sheridan, Jennifer

    1 Principles of Population Health Science Population Health 795 A course in the Program in Population Health Fall 2012 University of Wisconsin-Madison, School of Medicine and Public Health The lecture in medicine and public health, inequities in health persist. Understanding health on a population level

  2. Health And Wellness Department Of Health And Wellness

    E-Print Network [OSTI]

    McConnell, Terry

    Health And Wellness Department Of Health And Wellness Lutchmie Narine, Chair, 315-443-9630 426 The Department of Health and Wellness offers a 123-credit Bachelor of Science degree (B.S.) in public health. Our graduates are prepared to work in community health education and health promotion in public health agencies

  3. Competing retention pathways of uranium upon reaction with Fe(II)

    SciTech Connect (OSTI)

    Massey, Michael S.; Lezama Pacheco, Juan S.; Jones, Morris; Ilton, Eugene S.; Cerrato, Jose M.; Bargar, John R.; Fendorf, Scott

    2014-10-01

    Biogeochemical retention processes, including adsorption, reductive precipitation, and incorporation into host minerals, are important in contaminant transport, remediation, and geologic deposition of uranium. Recent work has shown that U can become incorporated into iron (hydr)oxide minerals, with a key pathway arising from Fe(II)-induced transformation of ferrihydrite, (Fe(OH)3•nH2O) to goethite (?-FeO(OH)); this is a possible U retention mechanism in soils and sediments. Several key questions, however, remain unanswered regarding U incorporation into iron (hydr)oxides and this pathway’s contribution to U retention, including: (i) the competitiveness of U incorporation versus reduction to U(IV) and subsequent precipitation of UO2; (ii) the oxidation state of incorporated U; (iii) the effects of uranyl aqueous speciation on U incorporation; and, (iv) the mechanism of U incorporation. Here we use a series of batch reactions conducted at pH ~7, [U(VI)] from 1 to 170 ?M, [Fe(II)] from 0 to 3 mM, and [Ca] at 0 or 4 mM) coupled with spectroscopic examination of reaction products of Fe(II)-induced ferrihydrite transformation to address these outstanding questions. Uranium retention pathways were identified and quantified using extended x-ray absorption fine structure (EXAFS) spectroscopy, x-ray powder diffraction, x-ray photoelectron spectroscopy, and transmission electron microscopy. Analysis of EXAFS spectra showed that 14 to 89% of total U was incorporated into goethite, upon reaction with Fe(II) and ferrihydrite. Uranium incorporation was a particularly dominant retention pathway at U concentrations ? 50 ?M when either uranyl-carbonato or calcium-uranyl-carbonato complexes were dominant, accounting for 64 to 89% of total U. With increasing U(VI) and Fe(II) concentrations, U(VI) reduction to U(IV) became more prevalent, but U incorporation remained a functioning retention pathway. These findings highlight the potential importance of U(V) incorporation within iron oxides as a retention process of U across a wide range of biogeochemical environments and the sensitivity of uranium retention processes to operative (bio)geochemical conditions.

  4. Virtual Institute of Microbial Stress and Survival: Deduction of Stress Response Pathways in Metal and Radionuclide Reducing Microorganisms

    SciTech Connect (OSTI)

    2004-04-17

    The projects application goals are to: (1) To understand bacterial stress-response to the unique stressors in metal/radionuclide contamination sites; (2) To turn this understanding into a quantitative, data-driven model for exploring policies for natural and biostimulatory bioremediation; (3) To implement proposed policies in the field and compare results to model predictions; and (4) Close the experimental/computation cycle by using discrepancies between models and predictions to drive new measurements and construction of new models. The projects science goals are to: (1) Compare physiological and molecular response of three target microorganisms to environmental perturbation; (2) Deduce the underlying regulatory pathways that control these responses through analysis of phenotype, functional genomic, and molecular interaction data; (3) Use differences in the cellular responses among the target organisms to understand niche specific adaptations of the stress and metal reduction pathways; (4) From this analysis derive an understanding of the mechanisms of pathway evolution in the environment; and (5) Ultimately, derive dynamical models for the control of these pathways to predict how natural stimulation can optimize growth and metal reduction efficiency at field sites.

  5. Directed Evolution of a Highly Efficient Cellobiose Utilizing Pathway in an Industrial Saccharomyces

    E-Print Network [OSTI]

    Zhao, Huimin

    Directed Evolution of a Highly Efficient Cellobiose Utilizing Pathway in an Industrial, this strategy was applied to optimize a cellobiose utilizing pathway in an industrial Saccharomyces cerevisiae

  6. Assessing Reliability in Transportation Energy Supply Pathways: A Hydrogen Case Study

    E-Print Network [OSTI]

    McCarthy, Ryan W.; Ogden, J

    2005-01-01

    in Transportation Energy Supply Pathways: A Hydrogen Casein Transportation Energy Supply Pathways: A Hydrogen Caseconcerns about energy supply security (and climate change)

  7. Chromatin landscaping in algae reveals novel regulation pathway for biofuels production

    E-Print Network [OSTI]

    Ngan, Chew Yee

    2014-01-01

    regulation pathway for biofuels production Chew Yee Ngan ,regulation pathway for biofuels production Chew Yee Ngan,for the development of biofuels. Biofuels are produced from

  8. Genome sequence of Thermofilum pendens reveals an exceptional loss of biosynthetic pathways without genome reduction

    E-Print Network [OSTI]

    Fenner, Marsha W

    2008-01-01

    glycolysis and gluconeogenesis pathways. Glyceraldehyde 3-glycolysis and/or in gluconeogenesis. Starch synthesis andis incorporated into the gluconeogenesis pathway, the AMP-

  9. Health Insurance Marketplace Notice New Health Insurance Marketplace...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Insurance Marketplace Notice New Health Insurance Marketplace Coverage Options and Your Health Coverage PART A: General Information When key parts of the health care law take...

  10. Polyprenyl-dependent glycan assembly pathways in microbial pathogens

    E-Print Network [OSTI]

    Hartley, Meredith Diane

    2011-01-01

    Polyisoprenyl-dependent glycan assembly pathways form the basis for the biosynthesis of many complex glycoconjugates. This thesis addresses key aspects of undecaprenyl-phosphate related processes; undecaprenol is the linear ...

  11. Interdisciplinary: Chemical Engineer/Mechanical Engineer (Pathways Recent Graduate Program)

    Broader source: Energy.gov [DOE]

    This is a Recent Graduate position in the Pathways Program. The program duration is one year and upon successful completion of the program requirements, the incumbent may be converted to a term,...

  12. Structural snapshots along the reaction pathway of Yersinia pestis...

    Office of Scientific and Technical Information (OSTI)

    pathway of Yersinia pestis RipA, a putative butyryl-CoA transferase The crystal structures of Y. pestis RipA mutants were determined to provide insights into the CoA...

  13. Integrating physical and genetic interaction networks for biological pathway discovery

    E-Print Network [OSTI]

    Bandyopadhyay, Sourav

    2010-01-01

    the DNA Damage Response (DDR) remain to be identified. Here,to uncovering the components of DDR pathways. Yeast has beenprograms associated with the DDR 7 , chIP-chip to identify

  14. Photovoltaic Lifetime & Degradation Science Statistical Pathway Development: Acrylic Degradation

    E-Print Network [OSTI]

    Rollins, Andrew M.

    Photovoltaic Lifetime & Degradation Science Statistical Pathway Development: Acrylic Degradation, USA ABSTRACT In order to optimize and extend the life of photovoltaics (PV) modules, scientific photovoltaics. The statisti- cally significant relationships were investigated using lifetime and degradation

  15. MAPK pathway: a role in development, disease and behaviour 

    E-Print Network [OSTI]

    Anastasaki, Korina

    2011-11-25

    Mutations in the RAS-RAF-MEK-ERK (MAPK) pathway give rise to a range of developmental disorders collectively referred to as the RASopathies. De novo germline mutations in patients suffering from these syndromes promote ...

  16. PROBING THE LIPOPROTEIN SECRETION PATHWAY IN BORRELIA BURGDORFERI

    E-Print Network [OSTI]

    Bridges, Kristina M.

    2012-05-31

    . Nevertheless, a block in the pathway does impact localization of subsurface lipoproteins as well as OM porins. Second, we demonstrated inner membrane localization of IpLA7, a major immunogenic protein in Lyme disease. Of the many predicted lipoproteins...

  17. Oscillatory Dynamics of the Extracellular Signal-regulated Kinase Pathway

    SciTech Connect (OSTI)

    Shankaran, Harish; Wiley, H. S.

    2010-12-01

    The extracellular signal-regulated kinase (ERK) pathway is a central signaling pathway in development and disease and is regulated by multiple negative and positive feedback loops. Recent studies have shown negative feedback from ERK to upstream regulators can give rise to biochemical oscillations with a periodicity of between 15-30 minutes. Feedback due to the stimulated transcription of negative regulators of the ERK pathway can also give rise to transcriptional oscillations with a periodicity of 1-2h. The biological significance of these oscillations is not clear, but recent evidence suggests that transcriptional oscillations participate in developmental processes, such as somite formation. Biochemical oscillations are more enigmatic, but could provide a mechanism for encoding different types of inputs into a common signaling pathway.

  18. Polyamine pathway contributes to the pathogenesis of Parkinson disease

    E-Print Network [OSTI]

    Lewandowski, Nicole M.

    The full complement of molecular pathways contributing to the pathogenesis of Parkinson disease (PD) remains unknown. Here we address this issue by taking a broad approach, beginning by using functional MRI to identify ...

  19. Pathways Towards Habitable Planets ASP Conference Series, Vol. 430, 2010

    E-Print Network [OSTI]

    Bordé, Pascal J.

    Pathways Towards Habitable Planets ASP Conference Series, Vol. 430, 2010 Vincent Coud´e du Foresto and Terrestrial Planet Finder Interferometer (TPF-I) missions. However, cost and technological issues

  20. Degradation Pathway Models for Photovoltaics Module Lifetime Performance

    E-Print Network [OSTI]

    Rollins, Andrew M.

    Degradation Pathway Models for Photovoltaics Module Lifetime Performance Nicholas R. Wheeler, Laura data from Underwriter Labs, featuring measurements taken on 18 identical photovoltaic (PV) modules in modules and their effects on module performance over lifetime. Index Terms--photovoltaics, statistical

  1. Health Center - 1 

    E-Print Network [OSTI]

    Unknown

    2009-01-01

    The United States is the only technologically advanced, industrialized country that fails to provide all of its citizenry with health care coverage.1 In 2010, an estimated 16.3% of Americans (approximately 50 million people) did not possess health...

  2. Downloads & Patient Materials - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health Education & Wellness > Downloads & Patient Materials Health Education & Wellness Downloads & Patient Materials Ergonomics Fitness & Exercise Men's Health Nutrition Health &...

  3. A multi-pathway model for Photosynthetic reaction center

    E-Print Network [OSTI]

    M. Qin; H. Z Shen; X. X. Yi

    2015-06-29

    Charge separation in light-harvesting complexes occurs in a pair of tightly coupled chlorophylls at the heart of photosynthetic reaction centers of both plants and bacteria. Recently it has been shown that quantum coherence can, in principle, enhance the efficiency of a solar cell, working like a quantum heat engine (QHE). Here, we propose a biological quantum heat engine (BQHE) motivated by Photosystem {\\rm II} reaction center (PS{\\rm II} RC) to describe the charge separation. Our model mainly considers two charge-separation pathways more than that in the published literature. The two pathways can interfere via cross-couplings and work together to enhance the charge-separation yields. We explore how these cross-couplings increase the current and voltage of the charge separation and discuss the advantages of multiple pathways in terms of current and power. The robustness of the BQHE against the charge recombination in natural PS{\\rm II} RC and dephasing induced by environments is also explored, and extension from two pathways to multiple pathways is made. These results suggest that nature-mimicking architectures with engineered multiple pathways for charge separations might be better for artificial solar energy devices.

  4. HEALTH SCIENCES Division of

    E-Print Network [OSTI]

    Cho, Hokwon

    HEALTH SCIENCES Division of University of nevada, Las vegas IMPACT How we serve our students, our community, and our state #12;academic impact UNLV's Division of Health Sciences is a vital force in the Las Vegas metropolitan area, educating desperately needed health care professionals and taking on some

  5. Health, Safety & Wellbeing Policy

    E-Print Network [OSTI]

    Mottram, Nigel

    Health, Safety & Wellbeing Policy Statement The University of Glasgow is one of the four oldest our very best to minimise the risk to the health, safety and wellbeing of staff, students, researchers resource and our students as our valued customers and partners. We acknowledge health and safety as a core

  6. HEALTH ALERT Meningococcal Meningitis

    E-Print Network [OSTI]

    Stanford, Kyle

    HEALTH ALERT Prevention Meningococcal Meningitis What is Meningococcal Meningitis? Meningococcal with someone confirmed to have this disease, immediately contact the Student Health Center or go to the nearest. Students: Check past medical records and contact Student Health Center if you did not receive your last

  7. Health Insurance Marketplace

    E-Print Network [OSTI]

    Acton, Scott

    About the Health Insurance Marketplace 8 things you can do to get ready now 1. Explore current options. You may be able to get coverage now through existing programs. Visit HealthCare.gov to learn more about health insurance for adults up to age 26 and programs for people and children in families

  8. Developing the Environmental Health

    E-Print Network [OSTI]

    Developing the Environmental Health Workforce Direct from CDC's Environmental Health Services Branch CAPT Michael E. Herring, R.E.H.S., M.P.H. Editor's note: NEHA strives to provide up-to-date and relevant information on environmental health and to build part- nerships

  9. Health Effects | Department of Energy

    Office of Environmental Management (EM)

    Worker Health & Safety Health Effects Health Effects The U.S. Department of Energy (DOE) administers research programs and monitoring activities, both domestic and...

  10. Occupational Health and Safety Manual

    E-Print Network [OSTI]

    Occupational Health and Safety Manual #12;1 Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 York University Occupational Health and Safety Policy and Programs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Occupational Health and Safety Legislation

  11. The Local Board of Health Environmental Health Primer

    E-Print Network [OSTI]

    Tools: EnvironmentalPolicy,Law,andAdministration.InThe Local Board of Health Environmental H Working to strengthen.). Management Tools: Environmental Policy, Law, and Administration Factsheet #12;The Local Board of Health Environmental Health Primer environmental health Background

  12. The Local Board of Health Environmental Health Primer

    E-Print Network [OSTI]

    The Local Board of Health Environmental Health Primer Injury Prevention Factsheet environmental health Background · Unintentionalinjuryandviolenceaccountsforapproximately30%ofallyearsof-relatedinjuries. · Recreationalwaterillnessesareillnessesthatarespreadbycontactwithcontaminated waterfromswimmingpools,spas,lakes,rivers,oroceans. Board of Health Actions

  13. Health Assessment Requirements Candidate Waiver Request Health Assessment Management System

    E-Print Network [OSTI]

    Sin, Peter

    Health Assessment Requirements Candidate Waiver Request Health Assessment Management System Please: To Position #: Position Title: Environmental Health & Safety Use Only Reviewer Name: ___________________ Effective Date: _______________ Comments: Revised: May 14, 2012 #12;Health Assessment Requirements Candidate

  14. Global Transition Dynamics: Unfolding the Full Social Implications of National Decision Pathways

    E-Print Network [OSTI]

    Amin, S. Massoud

    health, political, and technical--of major societal development activi- ties and technology programs. Forcing functions, critical junctures, and pinch points could be identified so that scarce development realization of this next step in analysis technology will require several years of dedicated international

  15. Women's Health - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    other materials pertaining to women's health that you can download. Related Links: Women: Stay Healthy at Any Age Women and Heart Disease Prevention Last Updated 09022014 2:44 PM...

  16. Health assessment for Northwest Transformer Salvage Yard National Priorities List (NPL) Site, Whatcom County, Washington, Region 10. CERCLIS No. WAD027315621. Final report

    SciTech Connect (OSTI)

    Not Available

    1989-04-14

    The Northwest Transformer Salvage Yard is a National Priorities List site located in Whatcom County, Washington, approximately two miles south of the town of Everson, Washington. Between 1958-1985, the site served as a storage and refurbishing area for electrical transformers, capacitors, and other electrical equipment. Subsequent sampling and analysis of on-site and off-site soils and groundwater revealed polychlorinated biphenyls, chlorinated dibenzo-p-dioxins, and chlorinated dibenzofurans. Potential pathways for human exposure to site contaminants include ingestion of fugitive dusts, and dermal contact with contaminated ground water, surface water, soil, or wood from an on-site building. Under current conditions the site poses a potential threat to human health in the event of unauthorized site entry, or the ingestion of contaminated ground water.

  17. The Local Board of Health Environmental Health Primer

    E-Print Network [OSTI]

    The Local Board of Health Environmental Health Primer Epidemiology Factsheet environmental health,case-control,andcohortstudiesandare designedtotesthypothesesregardingthefactorsthatcauseadisease. Board of Health Actions · EncourageenvironmentalhealthpersonneltobecomefamiliarwiththesystemsDefenseScorecards.Availableatwww.scorecard.org · Friis,R.(2007).EnvironmentalEpidemiology.InEssentials of Environmental Health. · NationalAssociationofLocalBoardsofHealth

  18. Introduction to Health Services Research Population Health 796

    E-Print Network [OSTI]

    Sheridan, Jennifer

    1 Introduction to Health Services Research Population Health 796 University of Wisconsin used in the field of health service research. What is health services research? Health services researchers focus on some of the most complex and challenging issues currently affecting health care

  19. Principles of Population Health Science Population Health 795

    E-Print Network [OSTI]

    Sheridan, Jennifer

    1 Principles of Population Health Science Population Health 795 A course in the Program in Population Health Fall 2011 University of Wisconsin-Madison, School of Medicine and Public Health OVERVIEW Despite significant advances in medicine and public health, inequities in health persist. Understanding

  20. Health Insurance after Graduation Individual Health Insurance in California

    E-Print Network [OSTI]

    Kammen, Daniel M.

    1 April 2010 Health Insurance after Graduation Individual Health Insurance in California Kathy Gage University of California, Berkeley Student Health Insurance Office Berkeley Law Presentation Spring Semester 2010 Health Care vs. Health Insurance Health Care is... Provision of Medical Services by · Private

  1. mir-30d Regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells

    SciTech Connect (OSTI)

    Yang, Xiaojun; Department of General Surgery, Gansu Provincial Hospital, Lanzhou, Gansu 710000 ; Zhong, Xiaomin; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011 ; Tanyi, Janos L.; Shen, Jianfeng; Xu, Congjian; Gao, Peng; Zheng, Tim M.; DeMichele, Angela; Zhang, Lin

    2013-02-15

    Highlights: ? Gene set enrichment analysis indicated mir-30d might regulate the autophagy pathway. ? mir-30d represses the expression of BECN1, BNIP3L, ATG12, ATG5 and ATG2. ? BECN1, BNIP3L, ATG12, ATG5 and ATG2 are direct targets of mir-30d. ? mir-30d inhibits autophagosome formation and LC3B-I conversion to LC3B-II. ? mir-30d regulates the autophagy process. -- Abstract: In human epithelial cancers, the microRNA (miRNA) mir-30d is amplified with high frequency and serves as a critical oncomir by regulating metastasis, apoptosis, proliferation, and differentiation. Autophagy, a degradation pathway for long-lived protein and organelles, regulates the survival and death of many cell types. Increasing evidence suggests that autophagy plays an important function in epithelial tumor initiation and progression. Using a combined bioinformatics approach, gene set enrichment analysis, and miRNA target prediction, we found that mir-30d might regulate multiple genes in the autophagy pathway including BECN1, BNIP3L, ATG12, ATG5, and ATG2. Our further functional experiments demonstrated that the expression of these core proteins in the autophagy pathway was directly suppressed by mir-30d in cancer cells. Finally, we showed that mir-30d regulated the autophagy process by inhibiting autophagosome formation and LC3B-I conversion to LC3B-II. Taken together, our results provide evidence that the oncomir mir-30d impairs the autophagy process by targeting multiple genes in the autophagy pathway. This result will contribute to understanding the molecular mechanism of mir-30d in tumorigenesis and developing novel cancer therapy strategy.

  2. TERMOD 2; an interactive code for analysing intake of radionuclides by man through terrestrial pathways

    E-Print Network [OSTI]

    Zach, R

    1978-01-01

    TERMOD 2; an interactive code for analysing intake of radionuclides by man through terrestrial pathways

  3. Developmental defects in zebrafish for classification of EGF pathway inhibitors

    SciTech Connect (OSTI)

    Pruvot, Benoist; Curé, Yoann; Djiotsa, Joachim; Voncken, Audrey; Muller, Marc

    2014-01-15

    One of the major challenges when testing drug candidates targeted at a specific pathway in whole animals is the discrimination between specific effects and unwanted, off-target effects. Here we used the zebrafish to define several developmental defects caused by impairment of Egf signaling, a major pathway of interest in tumor biology. We inactivated Egf signaling by genetically blocking Egf expression or using specific inhibitors of the Egf receptor function. We show that the combined occurrence of defects in cartilage formation, disturbance of blood flow in the trunk and a decrease of myelin basic protein expression represent good indicators for impairment of Egf signaling. Finally, we present a classification of known tyrosine kinase inhibitors according to their specificity for the Egf pathway. In conclusion, we show that developmental indicators can help to discriminate between specific effects on the target pathway from off-target effects in molecularly targeted drug screening experiments in whole animal systems. - Highlights: • We analyze the functions of Egf signaling on zebrafish development. • Genetic blocking of Egf expression causes cartilage, myelin and circulatory defects. • Chemical inhibition of Egf receptor function causes similar defects. • Developmental defects can reveal the specificity of Egf pathway inhibitors.

  4. The accurate and fast determination of carbon dioxide (CO2) levels is critical for many health and environmental applications. For example, the analysis of CO2 levels in exhaled breath

    E-Print Network [OSTI]

    The accurate and fast determination of carbon dioxide (CO2) levels is critical for many health of the sensor device. Chemical Engineering Doctoral Defense A Novel Handheld Real-time Carbon Dioxide Analyzer

  5. Health YorkU? Kinesiology & Health Science | Psychology | Nursing | Global Health

    E-Print Network [OSTI]

    Why choose Health YorkU? Kinesiology & Health Science | Psychology | Nursing | Global Health Health Studies (Management, Policy, Informatics, Health Studies) @ #12;State-of-the-Art Labs and Facilities #12;Real World Experience #12;Great Student Experience #12;Here's Why More course selections in Health than

  6. Algal Lipid Extraction and Upgrading to Hydrocarbons Technology Pathway

    SciTech Connect (OSTI)

    Davis, Ryan; Biddy, Mary J.; Jones, Susanne B.

    2013-03-31

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This technology pathway case investigates the cultivation of algal biomass followed by further lipid extraction and upgrading to hydrocarbon biofuels. Technical barriers and key research needs have been assessed in order for the algal lipid extraction and upgrading pathway to be competitive with petroleum-derived gasoline, diesel and jet range hydrocarbon blendstocks.

  7. Heterologous protein production using the twin arginine translocation pathway

    DOE Patents [OSTI]

    Pohlschroder, Mechtild (Philadelphia, PA); Kissinger, Jessica C (Athens, GA); Rose, R. Wesley (Glenside, PA); Brueser, Thomas (Halle, DE); Dilks, Kieran (Collingswood, NJ)

    2008-11-04

    Provided are means for evaluating and identifying putative substrates of the twin arginine translocation (Tat) secretory pathway in Streptomyces and other bacterial species. Also provided, therefore, are simple ways to express, secrete and purify correctly folded heterologous proteins on a large scale using host microorganisms, such as, Streptomyces and the Tat pathway therein. Many of the thus-produced proteins are of significant therapeutic value in the pharmaceutical and biochemical industries, particularly when they can be secreted from the host in fully-folded active form. Accordingly, there are further provided the heterologous proteins produced by the Tat secretion pathway using the foregoing methods, and the computer algorithm used to identify the Tat signal sequence and putative substrates.

  8. Catalytic Upgrading of Sugars to Hydrocarbons Technology Pathway

    SciTech Connect (OSTI)

    Biddy, Mary J.; Jones, Susanne B.

    2013-03-31

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to hydrocarbon fuels to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This technology pathway case investigates the catalytic conversion of solubilized carbohydrate streams to hydrocarbon biofuels, utilizing data from recent efforts within the National Advanced Biofuels Consortium (NABC) in collaboration with Virent, Inc.. Technical barriers and key research needs that should be pursued for the catalytic conversion of sugars pathway to be competitive with petroleum-derived gasoline, diesel and jet range hydrocarbon blendstocks have been identified.

  9. Biological Conversion of Sugars to Hydrocarbons Technology Pathway

    SciTech Connect (OSTI)

    Davis, Ryan; Biddy, Mary J.; Tan, Eric; Tao, Ling; Jones, Susanne B.

    2013-03-31

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This technology pathway case investigates the biological conversion of biomass derived sugars to hydrocarbon biofuels, utilizing data from recent literature references and information consistent with recent pilot scale demonstrations at NREL. Technical barriers and key research needs have been identified that should be pursued for the pathway to become competitive with petroleum-derived gasoline, diesel and jet range hydrocarbon blendstocks.

  10. Low energy pathways for reproducible in vivo protein folding

    E-Print Network [OSTI]

    Leonor Cruzeiro

    2011-01-03

    Two proteins, one belonging to the mainly alpha class and the other belonging to the alpha/beta class, are selected to test a kinetic mechanism for protein folding. Targeted molecular dynamics is applied to generate folding pathways for those two proteins, starting from two well defined initial conformations: a fully extended and a alpha-helical conformation. The results show that for both proteins the alpha-helical initial conformation provides overall lower energy pathways to the native state. For the alpha/beta protein, 30 % (40%) of the pathways from an initial alpha-helix (fully extended) structure lead to unentangled native folds, a success rate that can be increased to 85 % by the introduction of a well-defined intermediate structure. These results open up a new direction in which to look for a solution to the protein folding problem, as detailed at the end.

  11. Ex-Situ Catalytic Fast Pyrolysis Technology Pathway

    SciTech Connect (OSTI)

    Biddy, Mary J.; Dutta, Abhijit; Jones, Susanne B.; Meyer, Pimphan A.

    2013-03-31

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to hydrocarbon fuels to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This pathway case investigates converting woody biomass using ex-situ catalytic fast pyrolysis followed by upgrading to gasoline , diesel and jet range blendstocks . Technical barriers and key research needs that should be pursued for this pathway to be competitive with petroleum-derived blendstocks have been identified.

  12. In-Situ Catalytic Fast Pyrolysis Technology Pathway

    SciTech Connect (OSTI)

    Biddy, Mary J.; Dutta, Abhijit; Jones, Susanne B.; Meyer, Pimphan A.

    2013-03-31

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to hydrocarbon fuels to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This pathway case investigates converting woody biomass using in-situ catalytic fast pyrolysis followed by upgrading to gasoline, diesel, and jet range blendstocks. Technical barriers and key research needs that should be pursued for this pathway to be competitive with petroleum-derived blendstocks have been identified.

  13. Structural Health Monitoring Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    SHMTools SHMTools is a MATLAB package that facilitates the construction of structural health monitoring (SHM) processes. The package provides a set of functions or- ganized into...

  14. Structural Health Monitoring Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Figueiredo, E., Park, G., Figueiras, J., Farrar, C., & Worden, K. (2009). Structural Health Monitoring Algorithm Comparisons using Standard Data Sets. Los Alamos National...

  15. Structural Health Monitoring Tools

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Figueiredo, E., Park, G., Figueiras, J., Farrar, C., and Worden, K. (2009). Structural Health Monitoring Algorithm Comparisons Using Standard Datasets, Los Alamos National...

  16. GIS, SPATIAL STATISTICAL GRAPHICS, AND FOREST HEALTH.

    E-Print Network [OSTI]

    Symanzik, Jürgen

    1 GIS, SPATIAL STATISTICAL GRAPHICS, AND FOREST HEALTH. James J. Majure, Noel Cressie, Dianne Cook, and Jürgen Symanzik ABSTRACT This paper discusses the use of a geographic information systems (GIS), Arcview, into a geographic information system (GIS), Arcview 2.1 (ESRI 1995), and its use in the statistical analysis of spa

  17. Health impact assessment in planning: Development of the design for health HIA tools

    SciTech Connect (OSTI)

    Forsyth, Ann; Slotterback, Carissa Schively; Krizek, Kevin J.

    2010-01-15

    How can planners more systematically incorporate health concerns into practical planning processes? This paper describes a suite of health impact assessment tools (HIAs) developed specifically for planning practice. Taking an evidence-based approach the tools are designed to fit into existing planning activities. The tools include: a short audit tool, the Preliminary Checklist; a structured participatory workshop, the Rapid HIA; an intermediate health impact assessment, the Threshold Analysis; and a set of Plan Review Checklists. This description provides a basis for future work including assessing tool validity, refining specific tools, and creating alternatives.

  18. GRADUATE PROGRAMS IN PUBLIC HEALTH Master of Public Health

    E-Print Network [OSTI]

    Berdichevsky, Victor

    GRADUATE PROGRAMS IN PUBLIC HEALTH Master of Public Health Graduate Certificate of Public Health and Public Health Sciences Wayne State University School of Medicine September 2011 Accredited by: #12;_____________________________Graduate Programs in Public Health 2011-2012___________________________ Page 2 TABLE OF CONTENTS

  19. Health Information Systems for Primary Health Care: Thinking About Participation

    E-Print Network [OSTI]

    Sahay, Sundeep

    Health Information Systems for Primary Health Care: Thinking About Participation Elaine Byrne in supporting primary health care functioning, the design, development and implementation of these systems of complexity in the primary health system make the task of design, development and use of IS for primary health

  20. Health Sciences Allied health professionals change lives every day.

    E-Print Network [OSTI]

    Hayes, Jane E.

    Committed To A Brighter Tomorrow College of Health Sciences #12;Allied health professionals change, hospital or clinic, chances are your life will be impacted by a health sciences professional. Health sciences, or allied health, professionals come from many diverse disciplines. There are more than 200

  1. Public Health Principles and Practice Population Health Sciences 780

    E-Print Network [OSTI]

    Sheridan, Jennifer

    Public Health Principles and Practice Population Health Sciences 780 Fall 2011 This course examines population-based approaches to improve the health of the public. The focus will be on learning methods for community health improvement--from assessment to finding and implementing evidence based public health

  2. College of Health & Human Services 349 College of Health

    E-Print Network [OSTI]

    Xie,Jiang (Linda)

    College of Health & Human Services 349 College of Health and Human Services www.health.uncc.edu Dean: Karen Schmaling Associate Dean: Jane Neese In the College of Health and Human Services at the University of North Carolina at Charlotte, students and faculty help chart the course for health care

  3. Public Health Genomics Population Health Sciences 650 Section 023

    E-Print Network [OSTI]

    Sheridan, Jennifer

    Public Health Genomics Population Health Sciences 650 Section 023 Summer 2009, 07/20/09 ­ 07: Public health genomics is a new discipline that uses knowledge gained from genetic and molecular research and improve the health of the population often by enacting health services, programs, and policies

  4. Health and Safety Policy Statement4 Health and Safety Policy

    E-Print Network [OSTI]

    Haase, Markus

    Health and Safety Policy Statement4 Health and Safety Policy Statement UnIVERSITY OF LEEDS-based health and safety management system and workplace health framework, and by allocating the resources as a minimum l the development of a health and safety management framework based upon the University protocols

  5. {~.~ DEPARTMENT Of HEALTH & HUMAN ERVICES Public Health SaMea

    E-Print Network [OSTI]

    {~.~ DEPARTMENT Of HEALTH & HUMAN ERVICES "~~ Public Health SaMea Centers for Disease Control and Prevention (CDC) AUanta GA 30341-3724 February 27, 2004 Dear Environmental Health Colleague: The Environmental Health Services Branch is pleased to provide your agency with a copy of the Volusia County Health

  6. New Health Insurance Marketplace Coverage Options and Your Health Coverage

    E-Print Network [OSTI]

    Sun, Yi

    New Health Insurance Marketplace Coverage Options and Your Health Coverage PART A: General Information When key parts of the health care law take effect in 2014, there will be a new way to buy health insurance: the Health Insurance Marketplace. To assist you as you evaluate options for you and your family

  7. ENGINEERING AND HUMAN HEALTH

    E-Print Network [OSTI]

    Saskatchewan, University of

    ENGINEERING AND HUMAN HEALTH: FROM THE INSIDE OUT Engineering research on small scales could have huge health implications College of Engineering U N I V E R S I T Y O F S A S K ATC H E WA N CO L L E G 17 Alumni accolades College of Engineering THOROUGHUNIVERSITY OF SASKATCHEWAN COLLEGE OF ENGINEERING

  8. HEALTH CARE ASSOCIATION

    E-Print Network [OSTI]

    Leistikow, Bruce N.

    to meet the specific needs of your organization and to better inform your board members, senior management.g., Health Systems CFG, Home Health CFG, Pharmaceutical CFG, etc. The CFG's will provide an appropriate Chair, Drafting Committee Chairman, HCCA Pharmaceutical Compliance Focus Group HCCA Board Member HCCA

  9. Customized optimization of metabolic pathways by combinatorial transcriptional engineering

    E-Print Network [OSTI]

    Zhao, Huimin

    Engineering, Institute for Genomic Biology and 2 Departments of Chemistry, Biochemistry and BioengineeringCustomized optimization of metabolic pathways by combinatorial transcriptional engineering Jing Du1, 2012; Accepted May 15, 2012 ABSTRACT A major challenge in metabolic engineering and syn- thetic biology

  10. Questioning Inevitability of Energy Pathways: Alternative Energy Scenarios for California

    E-Print Network [OSTI]

    Kammen, Daniel M.

    Questioning Inevitability of Energy Pathways: Alternative Energy Scenarios for California May 21.6.4 Alternative Scenario 3 ­ Patriotic Energy Independence Section 3: Developing the Scenario Model and Examining, 2002 by Rebecca Ghanadan rebeccag@socrates.berkeley.edu The Energy and Resources Group University

  11. Roaming radical pathways for the decomposition of alkanes.

    SciTech Connect (OSTI)

    Harding, L. B.; Klippenstein, S. J.

    2010-01-01

    CASPT2 calculations predict the existence of roaming radical pathways for the decomposition of propane, n-butane, isobutane and neopentane. The roaming radical paths lead to the formation of an alkane and an alkene instead of the expected radical products. The predicted barriers for the roaming radical paths lie {approx}1 kcal/mol below the corresponding radical asymptotes.

  12. Algorithms for Detecting Significantly Mutated Pathways in Cancer

    E-Print Network [OSTI]

    Raphael, Ben J.

    Algorithms for Detecting Significantly Mutated Pathways in Cancer Fabio Vandin1, , Eli Upfal2 genome sequencing studies have shown that the so- matic mutations that drive cancer development functional mutations from sporadic, passenger mutations. Since cancer mutations are hypothesized to target

  13. A Pathway in Primate Brain for Internal Monitoring of

    E-Print Network [OSTI]

    Crawford, Doug

    - press MD relay neurons without affecting transthalamic fibers passing nearby. We test- ed monkeys circuits in the midbrain and pons (19), and some go upstream to mediodorsal thalamus (MD) relay neurons- ing pathway carries corollary discharges of saccadic commands. To test this hypothesis, first we

  14. Pathways to Laser Fusion Beyond NIF Fusion Power Associates Meeting

    E-Print Network [OSTI]

    Pathways to Laser Fusion Beyond NIF Fusion Power Associates Meeting Washington DC 10 December 2013 and hydrodynamic efficiency · Reduces risk from hydro and all laser plasma instabilities Multi-stage focal zooming · Demonstrate integrated physics / technologies for a power plant. · Tritium breeding, fusion power handling

  15. Hierarchical Protein Folding Pathways: A Computational Study of Protein Fragments

    E-Print Network [OSTI]

    Haspel, Nurit

    Hierarchical Protein Folding Pathways: A Computational Study of Protein Fragments Nurit Haspel,1 folding model. The model postulates that protein folding is a hierarchical top-down pro- cess. The basic words: protein folding; building blocks; pro- tein structure prediction; hierarchical folding; protein

  16. A Protein Export Pathway Involving Escherichia coli Porins

    E-Print Network [OSTI]

    McIntosh, Lawrence P.

    Structure Article A Protein Export Pathway Involving Escherichia coli Porins Gerd Prehna,1,2 Guijin@byron.biochem.ubc.ca (N.C.J.S.) DOI 10.1016/j.str.2012.04.014 SUMMARY Escherichia coli export the protein Yeb common to all E. coli strains has been reported, the mechanism of export has remained unclear. Herein, we

  17. Pathways Towards Habitable Planets ASP Conference Series, Vol. 430, 2010

    E-Print Network [OSTI]

    Complutense de Madrid, Universidad

    Pathways Towards Habitable Planets ASP Conference Series, Vol. 430, 2010 Vincent Coud´e du Foresto of terrestrial planet formation, for the habitability of the planetary systems and for water delivery into the terrestrial planet region? How common are Earth-like planets? These, and other related questions

  18. Biogas Production through the Syntrophic Acetate-Oxidising Pathway

    E-Print Network [OSTI]

    Biogas Production through the Syntrophic Acetate-Oxidising Pathway Characterisation and Detection Uppsala 2012 #12;Acta Universitatis agriculturae Sueciae 2012:45 #12;Biogas production through 1.1 Aims of the thesis 12 2 Biogas production 15 2.1 Biogas production in Europe 16 2.2 Substrate

  19. California Climate Policy to 2050: Pathways for Sustained Prosperity

    E-Print Network [OSTI]

    California at Davis, University of

    the economic implications of alternative pathways to our 2050 targets, including compatible 2030 targets. 16 restructuring the state's energy system. 16 February 2015 Preliminary and Confidential #12;Roland-Holst 5 Cap February 2015 Preliminary and Confidential #12;Roland-Holst 7 Electric Vehicle Adoption · The most rigorous

  20. Reaction Pathways for Oxygen Evolution Promoted by Cobalt Giuseppe Mattioli,*,

    E-Print Network [OSTI]

    Guidoni, Leonardo

    by such natural processes, the goal of artificial photosynthesis is to develop simplified but still efficient models in explicit water solution, we provide insight into the pathways for oxygen evolution of a cobalt routes to generate chemical fuels (e.g., H2) directly from sunlight by means of "artificial leafs",3,4 i

  1. 2002 Fusion Summer Study Development Pathway Subgroup (E 4)

    E-Print Network [OSTI]

    2002 Fusion Summer Study Development Pathway Subgroup (E 4) Final Report July 25, 2002 #12;6. Development Path Scenarios The development path to realize fusion as a practical energy source must include performance, steady-state operation; 4) Development of low-activation materials and fusion technologies

  2. 2002 Fusion Summer Study Subgroup E4 -Development Pathway Subgroup

    E-Print Network [OSTI]

    Najmabadi, Farrokh

    2002 Fusion Summer Study Subgroup E4 - Development Pathway Subgroup Draft by: Farrokh Najmabadi A burning plasma experiment is a key step in developing fusion. The realization of fusion, however, requires and fusion power technologies, etc. An important discriminator among various embodiments of burning plasma

  3. Alternative pathways to fusion energy (focus on Department of Energy

    E-Print Network [OSTI]

    Alternative pathways to fusion energy (focus on Department of Energy Innovative Confinement for a restructured fusion energy science program [5] 1996 | FESAC: Opportunities in Alternative Confinement Concepts, suggests program for Innovative Concepts [1] 1995 | OTA TPX and the Alternates [2] 1995 | PCAST (given flat

  4. TREATMENT OF MULTIVARIATE ENVIRONMENTAL AND HEALTH PROBLEMS ASSOCIATED WITH OIL SHALE TECHNOLOGY

    E-Print Network [OSTI]

    Kland, M.J.

    2010-01-01

    Applic.ation of Multivariate Analysis for Interpretation ofthe Proceedings TREATMENT OF MULTIVARIATE ENVIRONMENTAL ANDENG-48 TREATMENT OF MULTIVARIATE ENVIRONMENTAL AND HEALTH

  5. Electronic Health Information Literacy: An Investigation of the Electronic Health Information Knowledge and Skills of Health Education Majors 

    E-Print Network [OSTI]

    Hanik, Bruce Walter

    2012-07-16

    Health educators are expected to serve as resource of health knowledge and being e-health literate enable health educators to perform that function. However, the e-health literacy level of health education undergraduate students is rarely explored...

  6. A Heart Health Alaska Natives

    E-Print Network [OSTI]

    Shen, Jun

    Honoring the Gift of Heart Health A Heart Health Educator's Manual for Alaska Natives U . S . D E Health Service Office of Prevention, Education, and Control #12;Honoring the Gift of Heart Health A Heart National Heart, Lung, and Blood Institute and Indian Health Service NIH Publication No. 06-5218 Revised

  7. A Heart Health American Indians

    E-Print Network [OSTI]

    Shen, Jun

    Honoring the Gift of Heart Health A Heart Health Educator's Manual for American Indians U . S . D E Health Service Office of Prevention, Education, and Control #12;Honoring the Gift of Heart Health A Heart National Heart, Lung, and Blood Institute and Indian Health Service NIH Publication No. 06-5218 Revised

  8. Environmental Public Health Performance Standards

    E-Print Network [OSTI]

    Environmental Public Health Performance Standards (Version 2.0) Updated May 2014 National Center for Environmental Health Division of Emergency and Environmental Health Services #12;#12;Environmental Public Health Performance Standards (Version 2.0) Updated May 2014 #12;Environmental Public Health Performance Standards

  9. Health Status and Health Literacy in Older Adults 

    E-Print Network [OSTI]

    Fulton, Daphne Saxon

    2014-08-04

    This study aimed to examine the relationship between health literacy and the health status of older adults. The first section of the study consisted of a comprehensive literature review of prior research regarding cognitive, health, and behavioral...

  10. Health Fairs and Screenings - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    health fair schedule(s) on the right regarding health fairs in your area. Contact Health Education Services at 376-3939 or OMCHEW@rl.gov for questionscomment Related Links: Sept...

  11. Evaluation of Mental Health Emergency Preparedness Among Health Professionals

    E-Print Network [OSTI]

    Ablah, Elizabeth; Hawley, Suzanne; Konda, Kurt M.; Wolfe, Deborah; Cook, David J.

    2008-08-01

    The purpose of this study was to identify if health professionals report an increase in mental health preparedness abilities with having only two mental health components as part of a 2-day preparedness training conference. ...

  12. Modeling most likely pathways for smuggling radioactive and special nuclear materials on a worldwide multimodal transportation network

    SciTech Connect (OSTI)

    Saeger, Kevin J [Los Alamos National Laboratory; Cuellar, Leticia [Los Alamos National Laboratory

    2010-01-01

    Nuclear weapons proliferation is an existing and growing worldwide problem. To help with devising strategies and supporting decisions to interdict the transport of nuclear material, we developed the Pathway Analysis, Threat Response and Interdiction Options Tool (PATRIOT) that provides an analytical approach for evaluating the probability that an adversary smuggling radioactive or special nuclear material will be detected during transit. We incorporate a global, multi-modal transportation network, explicit representation of designed and serendipitous detection opportunities, and multiple threat devices, material types, and shielding levels. This paper presents the general structure of PATRIOT, and focuses on the theoretical framework used to model the reliabilities of all network components that are used to predict the most likely pathways to the target.

  13. Modeling most likely pathways for smuggling radioactive and special nuclear materials on a worldwide multi-modal transportation network

    SciTech Connect (OSTI)

    Saeger, Kevin J [Los Alamos National Laboratory; Cuellar, Leticia [Los Alamos National Laboratory

    2010-10-28

    Nuclear weapons proliferation is an existing and growing worldwide problem. To help with devising strategies and supporting decisions to interdict the transport of nuclear material, we developed the Pathway Analysis, Threat Response and Interdiction Options Tool (PATRIOT) that provides an analytical approach for evaluating the probability that an adversary smuggling radioactive or special nuclear material will be detected during transit. We incorporate a global, multi-modal transportation network, explicit representation of designed and serendipitous detection opportunities, and multiple threat devices, material types, and shielding levels. This paper presents the general structure of PATRIOT, all focuses on the theoretical framework used to model the reliabilities of all network components that are used to predict the most likely pathways to the target.

  14. Board of Health Recommendations for Hiring

    E-Print Network [OSTI]

    seek to assess their community's environmental health needs, develop policies and programs to meetBoard of Health Recommendations for Hiring Qualified Environmental Health Practitioners environmental health #12;Board of Health Recommendations for Hiring Qualified Environmental Health

  15. West Virginia University 1 Public Health

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    West Virginia University 1 Public Health Degrees Offered: Master of Public Health · Biostatistics · Epidemiology · Health Policy, Management and Leadership · Occupational and Environmental Health Sciences · Social and Behavioral Sciences Master of Public Health (Online) Master of Science · School Health

  16. Health Care at the Crossroads: Health Experiences and Perceived Health Access Among Emancipated Foster Youth in Alameda County, California

    E-Print Network [OSTI]

    Russell, Anika A

    2007-01-01

    different and their special health care needs. " PrimPediatrics (2002). "Health of Young Children in Foster2005). Fostering Health: Health Care for Children and

  17. Health News & InsideOut Newsletter - HPMC Occupational Health...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Newsletter Newsletter & Updates Health News & InsideOut Newsletter Emerging Infectious Diseases Pandemic Preparedness Progress on Childhood Obesity in Washington State Health News...

  18. Roadmap: Public Health Health Services Administration Bachelor of Science in Public Health

    E-Print Network [OSTI]

    Sheridan, Scott

    Roadmap: Public Health ­ Health Services Administration ­ Bachelor of Science in Public Health [PH-BSPH-PH-HSVA] College of Public Health Catalog Year: 2012­2013 Page 1 of 2 | Last Updated: 10-Apr-12/LNHD This roadmap One: [16 Credit Hours] PH 10001 Introduction to Public Health 3 US 10097 Destination Kent State

  19. Roadmap: Public Health Global Health Bachelor of Science in Public Health

    E-Print Network [OSTI]

    Sheridan, Scott

    Roadmap: Public Health ­ Global Health­ Bachelor of Science in Public Health [PH-BSPH-PH-GLHL] College of Public Health Catalog Year: 2013-2014 Page 1 of 3 | Last Updated: 24-Apr-2013/LNHD This roadmap One: [14 Credit Hours] PH 10001 Introduction to Public Health 3 US 10097 Destination Kent State

  20. Roadmap: Public Health Health Services Administration Bachelor of Science in Public Health

    E-Print Network [OSTI]

    Sheridan, Scott

    Roadmap: Public Health ­ Health Services Administration ­ Bachelor of Science in Public Health [PH-BSPH-PH-HSVA] College of Public Health Catalog Year: 2013-2014 Page 1 of 2 | Last Updated: 29-May-13/LNHD This roadmap One: [16 Credit Hours] PH 10001 Introduction to Public Health 3 US 10097 Destination Kent State

  1. Woods for Health Strategy Woods for Health Strategy | 32 | Woods for Health Strategy

    E-Print Network [OSTI]

    Strategy Woods for Health #12;Woods for Health Strategy Woods for Health Strategy | 32 | Woods for Health Strategy Foreword Like the rest of the western world, Scotland experiences growing rates a key role in helping to promote better physical and mental health for all by providing greenspace

  2. HEALTH SCIENCES www.wits.ac.za/health The Faculty of Health Sciences has

    E-Print Network [OSTI]

    Wagner, Stephan

    41 HEALTH SCIENCES www.wits.ac.za/health #12;42 The Faculty of Health Sciences has an outstanding Lorna Jacklin, winner of the Checkers-Shoprite Woman of the Year in 2008 in the category of Health) · Bachelor of Health Sciences - BHSc: (3 years) (there are two plans - Biomedical Sciences and Biokinetics

  3. UNITED STATES ARMY HEALTH PROFESSIONS

    E-Print Network [OSTI]

    McQuade, D. Tyler

    UNITED STATES ARMY HEALTH PROFESSIONS SCHOLARSHIP PROGRAM IN MEDICINE, DENTISTRY, VETERINARY MEDICINE, OPTOMETRY, CLINICAL PSYCHOLOGY AND NURSE ANESTHESIA WHAT IS THE ARMY'S HEALTH PROFESSIONS care field. It's called the F. Edward Hebert Armed Forces Health Professions Scholarship Program (HPSP

  4. CAPACITY BUILDING ACTIVITIES Public Health

    E-Print Network [OSTI]

    Hill, Wendell T.

    CAPACITY BUILDING ACTIVITIES School of Public Health Dean Principal Investigator Community Advisory System Faculty & Students School of Public Health Faculty & Students Prince George's County Washington, D.C. Community Members Practitioners, Residents and Public Health Professionals Research Projects Forum (CAC

  5. Accident Tolerant Fuel Analysis

    SciTech Connect (OSTI)

    Curtis Smith; Heather Chichester; Jesse Johns; Melissa Teague; Michael Tonks; Robert Youngblood

    2014-09-01

    Safety is central to the design, licensing, operation, and economics of Nuclear Power Plants (NPPs). Consequently, the ability to better characterize and quantify safety margin holds the key to improved decision making about light water reactor design, operation, and plant life extension. A systematic approach to characterization of safety margins and the subsequent margins management options represents a vital input to the licensee and regulatory analysis and decision making that will be involved. The purpose of the Risk Informed Safety Margin Characterization (RISMC) Pathway research and development (R&D) is to support plant decisions for risk-informed margins management by improving economics and reliability, and sustaining safety, of current NPPs. Goals of the RISMC Pathway are twofold: (1) Develop and demonstrate a risk-assessment method coupled to safety margin quantification that can be used by NPP decision makers as part of their margin recovery strategies. (2) Create an advanced “RISMC toolkit” that enables more accurate representation of NPP safety margin. In order to carry out the R&D needed for the Pathway, the Idaho National Laboratory is performing a series of case studies that will explore methods- and tools-development issues, in addition to being of current interest in their own right. One such study is a comparative analysis of safety margins of plants using different fuel cladding types: specifically, a comparison between current-technology Zircaloy cladding and a notional “accident-tolerant” (e.g., SiC-based) cladding. The present report begins the process of applying capabilities that are still under development to the problem of assessing new fuel designs. The approach and lessons learned from this case study will be included in future Technical Basis Guides produced by the RISMC Pathway. These guides will be the mechanism for developing the specifications for RISMC tools and for defining how plant decision makers should propose and evaluate margin recovery strategies.

  6. Accident tolerant fuel analysis

    SciTech Connect (OSTI)

    Smith, Curtis; Chichester, Heather; Johns, Jesse; Teague, Melissa; Tonks, Michael Idaho National Laboratory; Youngblood, Robert

    2014-09-01

    Safety is central to the design, licensing, operation, and economics of Nuclear Power Plants (NPPs). Consequently, the ability to better characterize and quantify safety margin holds the key to improved decision making about light water reactor design, operation, and plant life extension. A systematic approach to characterization of safety margins and the subsequent margins management options represents a vital input to the licensee and regulatory analysis and decision making that will be involved. The purpose of the Risk Informed Safety Margin Characterization (RISMC) Pathway research and development (R&D) is to support plant decisions for risk-informed margins management by improving economics and reliability, and sustaining safety, of current NPPs. Goals of the RISMC Pathway are twofold: (1) Develop and demonstrate a risk-assessment method coupled to safety margin quantification that can be used by NPP decision makers as part of their margin recovery strategies. (2) Create an advanced ''RISMC toolkit'' that enables more accurate representation of NPP safety margin. In order to carry out the R&D needed for the Pathway, the Idaho National Laboratory is performing a series of case studies that will explore methods- and tools-development issues, in addition to being of current interest in their own right. One such study is a comparative analysis of safety margins of plants using different fuel cladding types: specifically, a comparison between current-technology Zircaloy cladding and a notional ''accident-tolerant'' (e.g., SiC-based) cladding. The present report begins the process of applying capabilities that are still under development to the problem of assessing new fuel designs. The approach and lessons learned from this case study will be included in future Technical Basis Guides produced by the RISMC Pathway. These guides will be the mechanism for developing the specifications for RISMC tools and for defining how plant decision makers should propose and evaluate margin recovery strategies.

  7. ORISE: Health Promotion and Outreach

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health Promotion and Outreach Healthcare provider administering vaccination The Oak Ridge Institute for Science and Education (ORISE) provides health promotion and outreach support...

  8. ORISE: Applied health physics projects

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Applied health physics projects The Oak Ridge Institute for Science and Education (ORISE) provides applied health physics services to government agencies needing technical support...

  9. Business Affairs Environmental Health

    E-Print Network [OSTI]

    Wu, Dapeng Oliver

    Business Affairs Environmental Health & Safety Dive Safety Facility/Fire Safety/ Building Codes Radiation Control & Radiological Services Occupational Safety/ Industrial Hygiene Risk Management IFAS Facility Safety Indoor Air Quality Industrial Hygiene Hearing Conservation OSHA Safety Underground

  10. Data driven health system

    E-Print Network [OSTI]

    Rosen Ceruolo, Melissa Beth

    2013-01-01

    Effective use of data is believed to be the key to address systemic inefficiencies in health innovation and delivery, and to significantly enhance value creation for patients and all stakeholders. However, there is no ...

  11. Essays on health economics

    E-Print Network [OSTI]

    Shafrin, Jason T.

    2009-01-01

    The Quarterly Journal of Economics Davidson SM, Manheim LM,The Quarterly Journal of Economics 84(3): 488-500. Atella V,data. Journal of Health Economics 27(3): 770-785. Averett S

  12. Ownership and Health Care 

    E-Print Network [OSTI]

    Nighohossian, Jeremy

    2013-05-01

    The United States Health Care sector is a large and growing segment of the US economy. Herein, I present three distinct research projects regarding aspects of that industry, especially how it responds to public policy and government pro- grams. I...

  13. Health & Medicine Heart Disease

    E-Print Network [OSTI]

    Rogers, John A.

    See Also: Health & Medicine Heart Disease· Medical Imaging· Vioxx· Matter & Energy Electronics· Technology· Medical Technology· Reference Artificial heart· Biosensor· Circuit design· Machine· Science and stretchable electronics can map waves of electrical activity in the heart with better resolution and speed

  14. The NOD/RIP2 Pathway Is Essential for Host Defenses Against Chlamydophila pneumoniae Lung Infection

    E-Print Network [OSTI]

    2009-01-01

    McDonald C, Nun˜ez G (2005) NOD-LRR proteins: role in host-the TLR/MyD88 pathway, the Nod/ Rip2 signaling pathway alsooligomerization domain (Nod) proteins, has been suggested [

  15. Structural insights into the enzymes of the serine and biotin biosynthetic pathways in mycobacterium tuberculosis 

    E-Print Network [OSTI]

    Dey, Sanghamitra

    2009-05-15

    biosynthetic pathways for Mtb survival. In this study, enzymes from these pathways were characterized using X-ray crystallographic and biochemical studies. D-3-phosphoglycerate dehydrogenase (PGDH) catalyzes the first step of phosphorylated serine biosynthesis...

  16. Bioenergy Technologies Office R&D Pathways: In-Situ Catalytic...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    In-Situ Catalytic Fast Pyrolysis Bioenergy Technologies Office R&D Pathways: In-Situ Catalytic Fast Pyrolysis The in-situ catalytic fast pyrolysis pathway involves rapidly heating...

  17. Lifecycle impacts of natural gas to hydrogen pathways on urban air quality

    E-Print Network [OSTI]

    Wang, Guihua; Ogden, Joan M; Nicholas, Michael A

    2007-01-01

    of natural gas to hydrogen pathways on urban air qualityas natural gas extraction and oil re?ning) on air quality inquality impacts for three different hydrogen production and delivery pathways, based on steam methane reforming (SMR) of natural gas,

  18. VOICE-COILS AS RECIPROCAL TRANSDUCERS IN STRUCTURAL HEALTH MONITORING APPLICATIONS

    E-Print Network [OSTI]

    Boyer, Edmond

    VOICE-COILS AS RECIPROCAL TRANSDUCERS IN STRUCTURAL HEALTH MONITORING APPLICATIONS Patrik Fröjd in a seismic network for structural health monitoring purposes, transmitting relatively undamped low frequency for structural health monitoring of such structures are probably modal analysis of bending modes and Acoustic

  19. Source: Proceedings of the 4th International Workshop on Structural Health Monitoring, Stanford,

    E-Print Network [OSTI]

    Lynch, Jerome P.

    Source: Proceedings of the 4th International Workshop on Structural Health Monitoring, Stanford, CA is still a daunting problem in structural health monitoring and extreme event damage evaluation [1 series analysis of vibration signals was proposed by [3,4,5,6]. The structural health monitoring problem

  20. Integrated structural health monitoring.

    SciTech Connect (OSTI)

    Farrar, C. R. (Charles R.)

    2001-01-01

    Structural health monitoring is the implementation of a damage detection strategy for aerospace, civil and mechanical engineering infrastructure. Typical damage experienced by this infrastructure might be the development of fatigue cracks, degradation of structural connections, or bearing wear in rotating machinery. The goal of the research effort reported herein is to develop a robust and cost-effective structural health monitoring solution by integrating and extending technologies from various engineering and information technology disciplines. It is the authors opinion that all structural health monitoring systems must be application specific. Therefore, a specific application, monitoring welded moment resisting steel frame connections in structures subjected to seismic excitation, is described along with the motivation for choosing this application. The structural health monitoring solution for this application will integrate structural dynamics, wireless data acquisition, local actuation, micro-electromechanical systems (MEMS) technology, and statistical pattern recognition algorithms. The proposed system is based on an assessment of the deficiencies associated with many current structural health monitoring technologies including past efforts by the authors. This paper provides an example of the integrated approach to structural health monitoring being undertaken at Los Alamos National Laboratory and summarizes progress to date on various aspects of the technology development.

  1. Getting from here to there – energy technology transformation pathways in the EMF-27 scenarios

    SciTech Connect (OSTI)

    Krey, Volker; Luderer, Gunnar; Clarke, Leon E.; Kriegler, Elmar

    2014-04-01

    This apper discusses Getting from here to there – energy technology transformation pathways in the EMF-27 scenarios

  2. Roadmap: Integrated Health Studies -Health Sciences Bachelor of Science

    E-Print Network [OSTI]

    Sheridan, Scott

    Roadmap: Integrated Health Studies - Health Sciences ­ Bachelor of Science [EH-BS-IHS-HLSC] College Updated: 14-May-13/JS This roadmap is a recommended semester-by-semester plan of study for this major Elective (upper division) 3 See note 3 on page 3 #12;Roadmap: Integrated Health Studies - Health Sciences

  3. UNIVERSITY OF CONNECICUT HEALTH CENTER CORRECTIONAL MANAGED HEALTH CARE

    E-Print Network [OSTI]

    Oliver, Douglas L.

    UNIVERSITY OF CONNECICUT HEALTH CENTER CORRECTIONAL MANAGED HEALTH CARE POLICY AND PROCEDURES FOR USE WITHIN THE CONNECTICUT DEPARTMENT OF CORRECTION NUMBER: E 1.01 Page 1 of 2 INFORMATION ON HEALTH SERVICES Effective Date: 04/01/01 POLICY: University of Connecticut Health Center (UCHC), Correctional

  4. CAMBRIDGE HEALTH ALLIANCE Title: Conflict of Interest in Public Health

    E-Print Network [OSTI]

    CAMBRIDGE HEALTH ALLIANCE Title: Conflict of Interest in Public Health Service Funded Research Health Alliance (CHA) or by CHA investigators. This policy defines requirements for research staff Committee will make final determinations on the resolution of financial #12;Cambridge Health Alliance Title

  5. UNIVERSITY OF CONNECTICUT HEALTH CENTER CORRECTIONAL MANAGED HEALTH CARE

    E-Print Network [OSTI]

    Oliver, Douglas L.

    UNIVERSITY OF CONNECTICUT HEALTH CENTER CORRECTIONAL MANAGED HEALTH CARE POLICY AND PROCEDURES FOR USE WITHIN THE CONNECTICUT DEPARTMENT OF CORRECTION NUMBER: B 1.01 Page 1 of 2 INFECTION CONTROL of Connecticut Health Center (UCHC), Correctional Managed Health Care (CMHC) shall establish and maintain

  6. Climate Change and Human Health National Center for Environmental Health

    E-Print Network [OSTI]

    Climate Change and Human Health National Center for Environmental Health Division of Environmental Hazardsand Health Effects Paul Schramm,MS,MPH Climate and Health Program Centersfor Disease Control and Prevention October 17, 2012 #12;Coastal flooding Climate change effects: ·Temperature ·Sea level

  7. College of Public Health CPH College of Public Health

    E-Print Network [OSTI]

    MacAdam, Keith

    College of Public Health CPH College of Public Health KEY: # = new course * = course changed =coursedropped University of Kentucky 2013-2014 Undergraduate Bulletin 1 CPH 201 INTRODUCTION TO PUBLIC HEALTH(suchasHIVprevention,maternalandchildhealth,reducingobesityrates,andreducingtobaccoaddiction)willbecome focal points for the investigation of these strategies. #CPH 202 PUBLIC HEALTH THROUGH POPULAR FILM. (3

  8. Health Education Lesson Plans Health Education Lesson Plans

    E-Print Network [OSTI]

    de Lijser, Peter

    Health Education Lesson Plans Health Education Lesson Plans (Healthy Kids Resource Center; no lesson plans to download, but library of health curriculum http://www.hkresources.org/ Dairy Council://www.epa.gov/teachers For Lesson Plans http://www.forlessonplans.com Health Lessons Plans Web Quest http://www.edhelper.com/cat55

  9. Health Career Preparation Pre-Health Careers Checklist

    E-Print Network [OSTI]

    Amin, S. Massoud

    Health Career Preparation Pre-Health Careers Checklist The College of Continuing Education and the Health Careers Center have created a helpful checklist on how to explore and get started completing prerequisites for a health-related degree program (i.e. medical school, nursing, etc.). We recommend that you

  10. Health Information & Immunization Form Wake Forest University Student Health Service

    E-Print Network [OSTI]

    Anderson, Paul R.

    - A - Health Information & Immunization Form Wake Forest University Student Health Service P.O. Box or by a clinic or health department stamp. · High School Records--These may contain some, but not all, of your. · Local Health Department. · Previous College or University Records--Your immunization records do

  11. Policy on Environmental Health and Safety Policy on Environmental Health

    E-Print Network [OSTI]

    Sridhar, Srinivas

    Policy on Environmental Health and Safety 8/1/2014 Policy on Environmental Health and Safety I, teaching, research and other activities in compliance with environmental health and safety laws and regulations, and in accordance with recognized health, safety and sound environmental management practices

  12. Health and Pre-Professional Health care is currently Canada's

    E-Print Network [OSTI]

    Health and Pre-Professional Health care is currently Canada's second-largest service industry. In addition to traditional health-related roles (e.g., physician, nurse, dentist, pharmacist), a wealth of new health care careers are opening as a result of recent scientific, medical and technological advances

  13. UNIVERSITY HEALTH CENTER (UHC) NOTICE OF HEALTH INFORMATION

    E-Print Network [OSTI]

    Arnold, Jonathan

    UNIVERSITY HEALTH CENTER (UHC) NOTICE OF HEALTH INFORMATION PRIVACY PRACTICES THIS NOTICE DESCRIBES TO THIS INFORMATION. PLEASE REVIEW IT CAREFULLY. Understanding Your Health Record/Information Each time you visit or treatment. This information, often referred to as your health or medical record, serves as: · A basis

  14. Employee Health Services REPORT OF STUDENT HEALTH EVALUATION

    E-Print Network [OSTI]

    Anderson, Paul R.

    Employee Health Services REPORT OF STUDENT HEALTH EVALUATION WAKE FOREST SCHOOL OF MEDICINE; IT WILL BE USED ONLY AS BACKGROUND FOR PROVIDING HEALTH CARE, IF THIS IS NECESSARY. THIS INFORMATION IS STRICTLY FOR THE USE OF THE HEALTH SERVICE AND WILL NOT BE RELEASED WITHOUT STUDENT CONSENT. THANK YOU FOR YOUR

  15. Public Health in Public Housing: Improving Health, Changing Lives

    E-Print Network [OSTI]

    Shen, Jun

    Public Health in Public Housing: Improving Health, Changing Lives National Heart, Lung, and Blood Institute Education Strategy Development Workshop S U M M A R Y R E P O R T U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Heart, Lung, and Blood Institute #12;#12;U

  16. Brian Giebel Subject: FW: Faculty positions in Plant Genomics and Pathway Engineering at the JGI

    E-Print Network [OSTI]

    Borenstein, Elhanan

    1 Brian Giebel Subject: FW: Faculty positions in Plant Genomics and Pathway Engineering at the JGI: Faculty positions in Plant Genomics and Pathway Engineering at the JGI To: Jay Shendure coming out in Science targeted at recruiting individuals in plant genomics and pathway engineering

  17. Polymer Uncrossing and Knotting in Protein Folding, and Their Role in Minimal Folding Pathways

    E-Print Network [OSTI]

    Plotkin, Steven S.

    Polymer Uncrossing and Knotting in Protein Folding, and Their Role in Minimal Folding Pathways Ali induce dominant pathway mechanisms in protein folding. Citation: Mohazab AR, Plotkin SS (2013) Polymer Uncrossing and Knotting in Protein Folding, and Their Role in Minimal Folding Pathways. PLoS ONE 8(1): e53642

  18. Export Pathway Selectivity of Escherichia coli Twin Arginine Translocation Signal Peptides*S

    E-Print Network [OSTI]

    Georgiou, George

    Export Pathway Selectivity of Escherichia coli Twin Arginine Translocation Signal Peptides exported via the twin arginine translocation (Tat) path- way. Fusions of the putative Tat signal peptides peptides to direct export through the Tat pathway, through the general secretory pathway (Sec), or through

  19. ConTrack: Finding the most likely pathways between brain regions using diffusion tractography

    E-Print Network [OSTI]

    Wandell, Brian A.

    to identify the most likely pathways connecting two regions. In a series of experiments using human data, we for measuring white matter pathways in the living human brain. DFT is often used to discover new pathways algorithms. Keywords: diffusion imaging, fiber tractography, MT+, corpus callosum, optic radiation Citation

  20. The role of Erk MAPK pathway in CD4 T cell proliferation and differentiation

    E-Print Network [OSTI]

    Chang, Chiung-Fang

    2011-01-01

    B. (2010). Key role of ERK pathway signaling in lupus.and Hedrick, S.M. The role of Erk MAPK pathway in CD4 T cellTHE DISSERTATION The role of Erk MAPK pathway in CD4 T cell

  1. Nonlinear spectroscopy with entangled photons: Manipulating quantum pathways of matter Oleksiy Roslyak,* Christoph A. Marx,

    E-Print Network [OSTI]

    Mukamel, Shaul

    Nonlinear spectroscopy with entangled photons: Manipulating quantum pathways of matter Oleksiy be selected by using nonclassical fields, through the entanglement of photon and material pathways, which scattering and two-photon-absorption pathways in a pump-probe experiment are separated by controlling

  2. PROJECT PROFILE: Pace Energy and Climate Center (Solar Market Pathways) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergy Bills andOrder 422.1, CONDUCT P - . . -Pathways) | Department

  3. PROJECT PROFILE: Salt Lake City Corporation (Solar Market Pathways) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergy Bills andOrder 422.1, CONDUCT P - . . -Pathways) |

  4. PROJECT PROFILE: Solar Electric Power Association (Solar Market Pathways) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergy Bills andOrder 422.1, CONDUCT P - . . -Pathways) |Department of Energy

  5. PROJECT PROFILE: The Solar Foundation (Solar Market Pathways) | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURINGEnergy Bills andOrder 422.1, CONDUCT P - . . -Pathways) |Departmentof Energy

  6. A multi-pathway model for Photosynthetic reaction center

    E-Print Network [OSTI]

    Qin, M; Yi, X X

    2015-01-01

    Charge separation in light-harvesting complexes occurs in a pair of tightly coupled chlorophylls at the heart of photosynthetic reaction centers of both plants and bacteria. Recently it has been shown that quantum coherence can, in principle, enhance the efficiency of a solar cell, working like a quantum heat engine (QHE). Here, we propose a biological quantum heat engine (BQHE) motivated by Photosystem {\\rm II} reaction center (PS{\\rm II} RC) to describe the charge separation. Our model mainly considers two charge-separation pathways more than that in the published literature. The two pathways can interfere via cross-couplings and work together to enhance the charge-separation yields. We explore how these cross-couplings increase the current and voltage of the charge separation and discuss the advantages of multiple pathways in terms of current and power. The robustness of the BQHE against the charge recombination in natural PS{\\rm II} RC and dephasing induced by environments is also explored, and extension ...

  7. Enhancing a Pathway-Genome Database (PGDB) to Capture Subcellular Localization of Metabolites and Enzymes: The Nucleotide-Sugar Biosynthetic Pathways of Populus trichocarpa

    SciTech Connect (OSTI)

    Nag, A.; Karpinets, T. V.; Chang, C. H.; Bar-Peled, M.

    2012-01-01

    Understanding how cellular metabolism works and is regulated requires that the underlying biochemical pathways be adequately represented and integrated with large metabolomic data sets to establish a robust network model. Genetically engineering energy crops to be less recalcitrant to saccharification requires detailed knowledge of plant polysaccharide structures and a thorough understanding of the metabolic pathways involved in forming and regulating cell-wall synthesis. Nucleotide-sugars are building blocks for synthesis of cell wall polysaccharides. The biosynthesis of nucleotide-sugars is catalyzed by a multitude of enzymes that reside in different subcellular organelles, and precise representation of these pathways requires accurate capture of this biological compartmentalization. The lack of simple localization cues in genomic sequence data and annotations however leads to missing compartmentalization information for eukaryotes in automatically generated databases, such as the Pathway-Genome Databases (PGDBs) of the SRI Pathway Tools software that drives much biochemical knowledge representation on the internet. In this report, we provide an informal mechanism using the existing Pathway Tools framework to integrate protein and metabolite sub-cellular localization data with the existing representation of the nucleotide-sugar metabolic pathways in a prototype PGDB for Populus trichocarpa. The enhanced pathway representations have been successfully used to map SNP abundance data to individual nucleotide-sugar biosynthetic genes in the PGDB. The manually curated pathway representations are more conducive to the construction of a computational platform that will allow the simulation of natural and engineered nucleotide-sugar precursor fluxes into specific recalcitrant polysaccharide(s).

  8. BAYESIANSTATISTICS in Health Economics and

    E-Print Network [OSTI]

    Oakley, Jeremy

    aprimeron BAYESIANSTATISTICS in Health Economics and Outcomes Research BS EHC Centre for Bayesian Statistics in Health Economics BAYESIAN INITIATIVE IN HEALTH ECONOMICS & OUTCOMES RESEARCH #12;APrimeronBayesianStatisticsLuceO'Hagan #12;aprimeron BAYESIANSTATISTICS in Health Economics and Outcomes Research Bayesian Initiative

  9. open access journal Public Health

    E-Print Network [OSTI]

    Oakley, Jeremy

    open access journal Journal of Public Health in AfricaeISSN 2038-9930 i www the Journal of Public Health in Africa is a peer-reviewed, electronic quarterly, that focuses on health issues in the African continent. The journal editors seek high quality original articles on public health related issues

  10. Health Over the Life Course

    E-Print Network [OSTI]

    Strauss, John; Thomas, Duncan

    2007-01-01

    health assessments: Anthropometry Anthropometric measures,solid food intakes, and anthropometry at intervals which

  11. COLLEGE OF ENGINEERING Human Health

    E-Print Network [OSTI]

    COLLEGE OF ENGINEERING Human Health #12;Welcome to our Health issue ­ Please take the time to read the exciting stories about how our faculty, students, and alumni are engineering solutions to health care to tackle large worldwide health problems. A few years ago, the College of Engineering made a strategic

  12. Direct from CDC Environmental Health

    E-Print Network [OSTI]

    will be dealing with similar ecologic and health impacts, in cluding desertification (Neelin, Münnich, Su

  13. Health Care Basics: Choosing the

    E-Print Network [OSTI]

    Li, Mo

    2012 Health Care Basics: Choosing the Best Option for Your Health "Creating A More Educated Georgia" #12;Health Care Basics 2 Medical Options for Plan Year 2012 The University System of Georgia's Plan of Regents will offer the following health care options: · Blue Choice HMO · Kaiser Permanente HMO · HSA Open

  14. HEALTH AND SAFETY INDUCTION Introduction

    E-Print Network [OSTI]

    Mucina, Ladislav

    HEALTH AND SAFETY INDUCTION Introduction Welcome to Curtin's online health and safety induction University is committed to providing and maintaining high standards of health and safety so we can prevent with staff, and by continually improving our health and safety management system. This course is designed

  15. Direct from CDC Environmental Health

    E-Print Network [OSTI]

    Direct from CDC Environmental Health Services Branch CAPT John P. Sarisky, R.S., M.P.H. The Environmental Public Health Performance Standards: Strengthening the Nation's Environmental Public Health Infrastructure and Improving Environmental Health Practice Editor's note: NEHA strives to provide up

  16. Summary of Conceptual Models and Data Needs to Support the INL Remote-Handled Low-Level Waste Disposal Facility Performance Assessment and Composite Analysis

    SciTech Connect (OSTI)

    A. Jeff Sondrup; Annette L. Schafter; Arthur S. Rood

    2010-09-01

    An overview of the technical approach and data required to support development of the performance assessment, and composite analysis are presented for the remote handled low-level waste disposal facility on-site alternative being considered at Idaho National Laboratory. Previous analyses and available data that meet requirements are identified and discussed. Outstanding data and analysis needs are also identified and summarized. The on-site disposal facility is being evaluated in anticipation of the closure of the Radioactive Waste Management Complex at the INL. An assessment of facility performance and of the composite performance are required to meet the Department of Energy’s Low-Level Waste requirements (DOE Order 435.1, 2001) which stipulate that operation and closure of the disposal facility will be managed in a manner that is protective of worker and public health and safety, and the environment. The corresponding established procedures to ensure these protections are contained in DOE Manual 435.1-1, Radioactive Waste Management Manual (DOE M 435.1-1 2001). Requirements include assessment of (1) all-exposure pathways, (2) air pathway, (3) radon, and (4) groundwater pathway doses. Doses are computed from radionuclide concentrations in the environment. The performance assessment and composite analysis are being prepared to assess compliance with performance objectives and to establish limits on concentrations and inventories of radionuclides at the facility and to support specification of design, construction, operation and closure requirements. Technical objectives of the PA and CA are primarily accomplished through the development of an establish inventory, and through the use of predictive environmental transport models implementing an overarching conceptual framework. This document reviews the conceptual model, inherent assumptions, and data required to implement the conceptual model in a numerical framework. Available site-specific data and data sources are then addressed. Differences in required analyses and data are captured as outstanding data needs.

  17. Health and Safety Research Division progress report, April 1, 1981-September 30, 1982

    SciTech Connect (OSTI)

    Not Available

    1983-02-01

    Research progress for the reporting period is briefly summarized for the following sections: (1) health studies, (2) technology assessments, (3) biological and radiation physics, (4) chemical physics, (5) Office of Risk Analysis, and (6) health and environmental risk and analysis. (ACR)

  18. HotSpot Health Physics Codes

    SciTech Connect (OSTI)

    2013-04-18

    The HotSpot Health Physics Codes were created to provide emergency response personnel and emergency planners with a fast, field-portable set of software tools for evaluating insidents involving redioactive material. The software is also used for safety-analysis of facilities handling nuclear material. HotSpot provides a fast and usually conservative means for estimation the radiation effects associated with the short-term (less than 24 hours) atmospheric release of radioactive materials.

  19. ORISE: Health physics services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesseworkSURVEY UNIVERSE TheForensic Science ForensicHealth Promotion andHealth

  20. Global Health Center (GHC) Website Architecture

    E-Print Network [OSTI]

    Chapman, Michael S.

    Global Health Center (GHC) Website Architecture About Global Health Student Interest Group Contact) Leadership Electives (overview) PTGH Conversations in Global Health OHSU Global Health Grants Concentration in Global Health Studies Scholarship · Information · Awards · Reports News & Events Donate to the Center