National Library of Energy BETA

Sample records for health pathways analysis

  1. Pathway Analysis Revealed Potential Diverse Health Impacts of Flavonoids that Bind Estrogen Receptors

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ye, Hao; Ng, Hui; Sakkiah, Sugunadevi; Ge, Weigong; Perkins, Roger; Tong, Weida; Hong, Huixiao

    2016-03-26

    Flavonoids are frequently used as dietary supplements in the absence of research evidence regarding health benefits or toxicity. Furthermore, ingested doses could far exceed those received from diet in the course of normal living. Some flavonoids exhibit binding to estrogen receptors (ERs) with consequential vigilance by regulatory authorities at the U.S. EPA and FDA. Regulatory authorities must consider both beneficial claims and potential adverse effects, warranting the increases in research that has spanned almost two decades. Here, we report pathway enrichment of 14 targets from the Comparative Toxicogenomics Database (CTD) and the Herbal Ingredients’ Targets (HIT) database for 22 flavonoidsmore » that bind ERs. The selected flavonoids are confirmed ER binders from our earlier studies, and were here found in mainly involved in three types of biological processes, ER regulation, estrogen metabolism and synthesis, and apoptosis. Besides cancers, we conjecture that the flavonoids may affect several diseases via apoptosis pathways. We find diseases such as amyotrophic lateral sclerosis, viral myocarditis and non-alcoholic fatty liver disease could be implicated. More generally, apoptosis processes may be importantly evolved biological functions of flavonoids that bind ERs and high dose ingestion of those flavonoids could adversely disrupt the cellular apoptosis process.« less

  2. Global Pathways Analysis Tool (GPAT)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathways Analysis Tool (GPAT) (Sandia National Laboratories) Objectives Calculate least-cost pathways for hydrogen supply for eight participating countries: France, Germany, ...

  3. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production Report documenting the ...

  4. Techno-Economic Boundary Analysis of Biological Pathways to Hydrogen...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Techno-Economic Boundary Analysis of Biological Pathways to Hydrogen Production (2009) Techno-Economic Boundary Analysis of Biological Pathways to Hydrogen Production (2009) ...

  5. Supply Chain Sustainability Analysis of Three Biofuel Pathways...

    Office of Scientific and Technical Information (OSTI)

    Supply Chain Sustainability Analysis of Three Biofuel Pathways Citation Details In-Document Search Title: Supply Chain Sustainability Analysis of Three Biofuel Pathways The ...

  6. Final report on the Pathway Analysis Task

    SciTech Connect (OSTI)

    Whicker, F.W.; Kirchner, T.B.

    1993-04-01

    The Pathway Analysis Task constituted one of several multi-laboratory efforts to estimate radiation doses to people, considering all important pathways of exposure, from the testing of nuclear devices at the Nevada Test Site (NTS). The primary goal of the Pathway Analysis Task was to predict radionuclide ingestion by residents of Utah, Nevada, and portions of seven other adjoining western states following radioactive fallout deposition from individual events at the NTS. This report provides comprehensive documentation of the activities and accomplishments of Colorado State University`s Pathway Analysis Task during the entire period of support (1979--91). The history of the project will be summarized, indicating the principal dates and milestones, personnel involved, subcontractors, and budget information. Accomplishments, both primary and auxiliary, will be summarized with general results rather than technical details being emphasized. This will also serve as a guide to the reports and open literature publications produced, where the methodological details and specific results are documented. Selected examples of results on internal dose estimates are provided in this report because the data have not been published elsewhere.

  7. Deduction and Analysis of the Interacting Stress Response Pathways...

    Office of Scientific and Technical Information (OSTI)

    Deduction and Analysis of the Interacting Stress Response Pathways of MetalRadionuclide-reducing Bacteria Citation Details In-Document Search Title: Deduction and Analysis of the ...

  8. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Production | Department of Energy Boundary Analysis of Biological Pathways to Hydrogen Production Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production Report documenting the biological and engineering characteristics of five algal and bacterial hydrogen production systems selected by DOE and NREL for evaluation. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production (3.63 MB) More Documents & Publications Techno-Economic Boundary Analysis

  9. Hydrogen Supply: Cost Estimate for Hydrogen Pathways-Scoping Analysis.

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    January 22, 2002-July 22, 2002 | Department of Energy Supply: Cost Estimate for Hydrogen Pathways-Scoping Analysis. January 22, 2002-July 22, 2002 Hydrogen Supply: Cost Estimate for Hydrogen Pathways-Scoping Analysis. January 22, 2002-July 22, 2002 A report showing a comparative scooping economic analysis of 19 pathways for producing, handling, distributing, and dispensing hydrogen for fuel cell vehicle applications. 32525.pdf (1.48 MB) More Documents & Publications Analysis of a Cluster

  10. Pathway analysis for a contaminated landfill in Middlesex, New Jersey

    SciTech Connect (OSTI)

    Yu, C.; Merry-Libby, P.; Yang, J.Y.

    1985-01-01

    Under the Formerly Utilized Sites Remedial Action Program, the US Department of Energy began excavating contaminated materials from the Middlesex Municipal landfill in 1984. A total of 16,000 mT of landfill materials covering a 0.2-ha area was excavated, of which 11,000 mT was contaminated and has been transported to the nearby sampling plant site for interim storage. Based on the pathway analysis for the onsite and near-site resident scenarios, the radiation dose rates and radionuclide concentrations in groundwater would be below the regulatory requirements for both the short-term and long-term scenarios. Hence, the potential health risks to maximally exposed individuals due to radioactive releases from the Middlesex landfill would be insignificant.

  11. CRITICAL RADIONUCLIDE AND PATHWAY ANALYSIS FOR THE SAVANNAH RIVER SITE

    SciTech Connect (OSTI)

    Jannik, T.

    2011-08-30

    This report is an update to the analysis, Assessment of SRS Radiological Liquid and Airborne Contaminants and Pathways, that was performed in 1997. An electronic version of this large original report is included in the attached CD to this report. During the operational history (1954 to the present) of the Savannah River Site (SRS), many different radionuclides have been released to the environment from the various production facilities. However, as will be shown by this updated radiological critical contaminant/critical pathway analysis, only a small number of the released radionuclides have been significant contributors to potential doses and risks to offsite people. The analysis covers radiological releases to the atmosphere and to surface waters, the principal media that carry contaminants offsite. These releases potentially result in exposure to offsite people. The groundwater monitoring performed at the site shows that an estimated 5 to 10% of SRS has been contaminated by radionuclides, no evidence exists from the extensive monitoring performed that groundwater contaminated with these constituents has migrated off the site (SRS 2011). Therefore, with the notable exception of radiological source terms originating from shallow surface water migration into site streams, onsite groundwater was not considered as a potential exposure pathway to offsite people. In addition, in response to the Department of Energy's (DOE) Order 435.1, several Performance Assessments (WSRC 2008; LWO 2009; SRR 2010; SRR 2011) and a Comprehensive SRS Composite Analysis (SRNO 2010) have recently been completed at SRS. The critical radionuclides and pathways identified in these extensive reports are discussed and, where applicable, included in this analysis.

  12. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Subcontract Report NREL/SR-560-46674 September 2009 Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production March 27, 2008 - August 31, 2009 B.D. James, G.N. Baum, J. Perez, and K.N. Baum Directed Technologies, Inc. Arlington, Virginia National Renewable Energy Laboratory 1617 Cole Boulevard, Golden, Colorado 80401-3393 303-275-3000 * www.nrel.gov NREL is a national laboratory of the U.S. Department of Energy Office of Energy Efficiency and Renewable Energy Operated by the

  13. Decision Analysis Tool to Compare Energy Pathways for Transportation

    SciTech Connect (OSTI)

    Bloyd, Cary N.

    2010-06-30

    With the goals of reducing greenhouse gas emissions, oil imports, and energy costs, a wide variety of automotive technologies are proposed to replace the traditional gasoline-powered internal combustion engine (g-ICE). Biomass is seen as an important domestic energy feedstock, and there are multiple pathways in which it can be linked to the transport sector. Contenders include the use of cellulosic ethanol from biomass to replace gasoline or the use of a biomass-fueled combined cycle electrical power generation facility in conjunction plug-in hybrid electric vehicles (PHEVs). This paper reviews a project that is developing a scenario decision analysis tool to assist policy makers, program managers, and others to obtain a better understanding of these uncertain possibilities and how they may interact over time.

  14. Supply Chain Sustainability Analysis of Three Biofuel Pathways

    SciTech Connect (OSTI)

    Jacob J. Jacobson; Erin Searcy; Kara Cafferty; Jennifer B. Dunn; Michael Johnson; Zhichao Wang; Michael Wang; Mary Biddy; Abhijit Dutta; Daniel Inman; Eric Tan; Sue Jones; Lesley Snowden-Swan

    2013-11-01

    The Department of Energy’s (DOE) Bioenergy Technologies Office (BETO) collaborates with industrial, agricultural, and non-profit partners to develop and deploy biofuels and other biologically-derived products. As part of this effort, BETO and its national laboratory teams conduct in-depth techno-economic assessments (TEA) of technologies to produce biofuels as part state of technology (SOT) analyses. An SOT assesses progress within and across relevant technology areas based on actual experimental results relative to technical targets and cost goals from design cases and includes technical, economic, and environmental criteria as available. Overall assessments of biofuel pathways begin with feedstock production and the logistics of transporting the feedstock from the farm or plantation to the conversion facility or biorefinery. The conversion process itself is modeled in detail as part of the SOT analysis. The teams then develop an estimate of the biofuel minimum selling price (MSP) and assess the cost competitiveness of the biofuel with conventional fuels such as gasoline.

  15. 2013-01 "Action in Analysis of Disposal Pathways for Disposition of 33

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Shafts" | Department of Energy 1 "Action in Analysis of Disposal Pathways for Disposition of 33 Shafts" 2013-01 "Action in Analysis of Disposal Pathways for Disposition of 33 Shafts" The intent of this Recommendation 2013-01 remains the same as 2010-01, namely to discourage inaction in addressing the permanent disposition of the 33 shafts. Rec 2013-01 - January 30, 2013 (204.48

  16. Employee Job Task Analysis (EJTA) - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Occupational Health Services > Employee Job Task Analysis (EJTA) Occupational Health Services Behavioral Health Services Beryllium Beryllium-Associated Worker Registry Employee Job Task Analysis (EJTA) Environmental Management System (EMS) Industrial Rehabilitation & Ergonomics Infection Control & Immunizations Influenza Immunization Program Medical Exam Scheduling Return to Work Risk Communication Employee Job Task Analysis (EJTA) Email Email Page | Print Print Page | Text Increase

  17. Completing the link between exposure science and toxicology for improved environmental health decision making: The aggregate exposure pathway framework

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Teeguarden, Justin G.; Tan, Yu -Mei; Edwards, Stephen W.; Leonard, Jeremy A.; Anderson, Kim A.; Corley, Richard A.; Kile, Molly L.; Simonich, Staci M.; Stone, David; Tanguay, Robert L.; et al

    2016-01-13

    Here, driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of observation to a field of prediction. Deployment of an organizational and predictive framework for exposure science analogous to the “systems approaches” used in the biological sciences is a necessary step in this evolution. Here we propose the aggregate exposure pathway (AEP) concept as the natural and complementary companion in the exposure sciences to the adverse outcome pathway (AOP) concept in the toxicological sciences.more » Aggregate exposure pathways offer an intuitive framework to organize exposure data within individual units of prediction common to the field, setting the stage for exposure forecasting. Looking farther ahead, we envision direct linkages between aggregate exposure pathways and adverse outcome pathways, completing the source to outcome continuum for more meaningful integration of exposure assessment and hazard identification. Together, the two frameworks form and inform a decision-making framework with the flexibility for risk-based, hazard-based, or exposure-based decision making.« less

  18. Decision Analysis Tool to Compare Energy Pathways for Transportation

    SciTech Connect (OSTI)

    Bloyd, Cary N.; Stork, Kevin

    2011-02-01

    With the goals of reducing greenhouse gas emissions, oil imports, and energy costs, a wide variety of automotive technologies are proposed to replace the traditional gasoline-powered internal combustion engine (g-ICE). A prototype model, Analytica Transportation Energy Analysis Model (ATEAM), has been developed using the Analytica decision modeling environment, visualizing the structure as a hierarchy of influence diagrams. The report summarized the FY2010 ATEAM accomplishments.

  19. Integrated analysis of hydrogen passenger vehicle transportation pathways

    SciTech Connect (OSTI)

    Thomas, C.E.; James, B.D.; Lomax, F.D. Jr.; Kuhn, I.F. Jr.

    1998-08-01

    Hydrogen-powered fuel cell vehicles will reduce local air pollution, greenhouse gas emissions and oil imports. Other alternative vehicles such as gasoline- or methanol-powered fuel cell vehicles, natural gas vehicles and various hybrid electric vehicles with internal combustion engines may also provide significant environmental and national security advantages. This report summarizes a two-year project to compare the direct hydrogen fuel cell vehicle with other alternatives in terms of estimated cost and estimated societal benefits, all relative to a conventional gasoline-powered internal combustion engine vehicle. The cost estimates used in this study involve ground-up, detailed analysis of the major components of a fuel cell vehicle system, assuming mass production in automotive quantities. The authors have also estimated the cost of both gasoline and methanol onboard fuel processors, as well as the cost of stationary hydrogen fueling system components including steam methane reformers, electrolyzers, compressors and stationary storage systems. Sixteen different vehicle types are compared with respect to mass production cost, local air pollution and greenhouse gas emissions.

  20. Transcriptomic analysis in the developing zebrafish embryo after compound exposure: Individual gene expression and pathway regulation

    SciTech Connect (OSTI)

    Hermsen, Sanne A.B.; Pronk, Tessa E.; Brandhof, Evert-Jan van den; Ven, Leo T.M. van der; Piersma, Aldert H.

    2013-10-01

    The zebrafish embryotoxicity test is a promising alternative assay for developmental toxicity. Classically, morphological assessment of the embryos is applied to evaluate the effects of compound exposure. However, by applying differential gene expression analysis the sensitivity and predictability of the test may be increased. For defining gene expression signatures of developmental toxicity, we explored the possibility of using gene expression signatures of compound exposures based on commonly expressed individual genes as well as based on regulated gene pathways. Four developmental toxic compounds were tested in concentration-response design, caffeine, carbamazepine, retinoic acid and valproic acid, and two non-embryotoxic compounds, D-mannitol and saccharin, were included. With transcriptomic analyses we were able to identify commonly expressed genes, which were mostly development related, after exposure to the embryotoxicants. We also identified gene pathways regulated by the embryotoxicants, suggestive of their modes of action. Furthermore, whereas pathways may be regulated by all compounds, individual gene expression within these pathways can differ for each compound. Overall, the present study suggests that the use of individual gene expression signatures as well as pathway regulation may be useful starting points for defining gene biomarkers for predicting embryotoxicity. - Highlights: • The zebrafish embryotoxicity test in combination with transcriptomics was used. • We explored two approaches of defining gene biomarkers for developmental toxicity. • Four compounds in concentration-response design were tested. • We identified commonly expressed individual genes as well as regulated gene pathways. • Both approaches seem suitable starting points for defining gene biomarkers.

  1. Probabilistic approach to identify sensitive parameter distributions in multimedia pathway analysis.

    SciTech Connect (OSTI)

    Kamboj, S.; Gnanapragasam, E.; LePoire, D.; Biwer, B. M.; Cheng, J.; Arnish, J.; Yu, C.; Chen, S. Y.; Mo, T.; Abu-Eid, R.; Thaggard, M.; Environmental Assessment; NRC

    2002-01-01

    Sensitive parameter distributions were identified with the use of probabilistic analysis in the RESRAD computer code. RESRAD is a multimedia pathway analysis code designed to evaluate radiological exposures resulting from radiological contamination in soil. The dose distribution was obtained by using a set of default parameter distribution/values. Most of the variations in the output dose distribution could be attributed to uncertainty in a small set of input parameters that could be considered as sensitive parameter distributions. The identification of the sensitive parameters is a first step in the prioritization of future research and information gathering. When site-specific parameter distribution/values are available for an actual site, the same process should be used with these site-specific data. Regression analysis used to identify sensitive parameters indicated that the dominant pathways depended on the radionuclide and source configurations. However, two parameter distributions were sensitive for many radionuclides: the external shielding factor when external exposure was the dominant pathway and the plant transfer factor when plant ingestion was the dominant pathway. No single correlation or regression coefficient can be used alone to identify sensitive parameters in all the cases. The coefficients are useful guides, but they have to be used in conjunction with other aids, such as scatter plots, and should undergo further analysis.

  2. Uncertainty and sensitivity analysis of food pathway results with the MACCS Reactor Accident Consequence Model

    SciTech Connect (OSTI)

    Helton, J.C.; Johnson, J.D.; Rollstin, J.A.; Shiver, A.W.; Sprung, J.L.

    1995-01-01

    Uncertainty and sensitivity analysis techniques based on Latin hypercube sampling, partial correlation analysis and stepwise regression analysis are used in an investigation with the MACCS model of the food pathways associated with a severe accident at a nuclear power station. The primary purpose of this study is to provide guidance on the variables to be considered in future review work to reduce the uncertainty in the important variables used in the calculation of reactor accident consequences. The effects of 87 imprecisely-known input variables on the following reactor accident consequences are studied: crop growing season dose, crop long-term dose, milk growing season dose, total food pathways dose, total ingestion pathways dose, total long-term pathways dose, area dependent cost, crop disposal cost, milk disposal cost, condemnation area, crop disposal area and milk disposal area. When the predicted variables are considered collectively, the following input variables were found to be the dominant contributors to uncertainty: fraction of cesium deposition on grain fields that is retained on plant surfaces and transferred directly to grain, maximum allowable ground concentrations of Cs-137 and Sr-90 for production of crops, ground concentrations of Cs-134, Cs-137 and I-131 at which the disposal of milk will be initiated due to accidents that occur during the growing season, ground concentrations of Cs-134, I-131 and Sr-90 at which the disposal of crops will be initiated due to accidents that occur during the growing season, rate of depletion of Cs-137 and Sr-90 from the root zone, transfer of Sr-90 from soil to legumes, transfer of Cs-137 from soil to pasture, transfer of cesium from animal feed to meat, and the transfer of cesium, iodine and strontium from animal feed to milk.

  3. Aligning ontologies and integrating textual evidence for pathway analysis of microarray data

    SciTech Connect (OSTI)

    Gopalan, Banu; Posse, Christian; Sanfilippo, Antonio P.; Stenzel-Poore, Mary; Stevens, S.L.; Castano, Jose; Beagley, Nathaniel; Riensche, Roderick M.; Baddeley, Bob; Simon, R.P.; Pustejovsky, James

    2006-10-08

    Expression arrays are introducing a paradigmatic change in biology by shifting experimental approaches from single gene studies to genome-level analysis, monitoring the ex-pression levels of several thousands of genes in parallel. The massive amounts of data obtained from the microarray data needs to be integrated and interpreted to infer biological meaning within the context of information-rich pathways. In this paper, we present a methodology that integrates textual information with annotations from cross-referenced ontolo-gies to map genes to pathways in a semi-automated way. We illustrate this approach and compare it favorably to other tools by analyzing the gene expression changes underlying the biological phenomena related to stroke. Stroke is the third leading cause of death and a major disabler in the United States. Through years of study, researchers have amassed a significant knowledge base about stroke, and this knowledge, coupled with new technologies, is providing a wealth of new scientific opportunities. The potential for neu-roprotective stroke therapy is enormous. However, the roles of neurogenesis, angiogenesis, and other proliferative re-sponses in the recovery process following ischemia and the molecular mechanisms that lead to these processes still need to be uncovered. Improved annotation of genomic and pro-teomic data, including annotation of pathways in which genes and proteins are involved, is required to facilitate their interpretation and clinical application. While our approach is not aimed at replacing existing curated pathway databases, it reveals multiple hidden relationships that are not evident with the way these databases analyze functional groupings of genes from the Gene Ontology.

  4. Well-to-wheels analysis of fast pyrolysis pathways with the GREET model.

    SciTech Connect (OSTI)

    Han, J.; Elgowainy, A.; Palou-Rivera, I.; Dunn, J.B.; Wang, M.Q.

    2011-12-01

    The pyrolysis of biomass can help produce liquid transportation fuels with properties similar to those of petroleum gasoline and diesel fuel. Argonne National Laboratory conducted a life-cycle (i.e., well-to-wheels [WTW]) analysis of various pyrolysis pathways by expanding and employing the Greenhouse Gases, Regulated Emissions, and Energy Use in Transportation (GREET) model. The WTW energy use and greenhouse gas (GHG) emissions from the pyrolysis pathways were compared with those from the baseline petroleum gasoline and diesel pathways. Various pyrolysis pathway scenarios with a wide variety of possible hydrogen sources, liquid fuel yields, and co-product application and treatment methods were considered. At one extreme, when hydrogen is produced from natural gas and when bio-char is used for process energy needs, the pyrolysis-based liquid fuel yield is high (32% of the dry mass of biomass input). The reductions in WTW fossil energy use and GHG emissions relative to those that occur when baseline petroleum fuels are used, however, is modest, at 50% and 51%, respectively, on a per unit of fuel energy basis. At the other extreme, when hydrogen is produced internally via reforming of pyrolysis oil and when bio-char is sequestered in soil applications, the pyrolysis-based liquid fuel yield is low (15% of the dry mass of biomass input), but the reductions in WTW fossil energy use and GHG emissions are large, at 79% and 96%, respectively, relative to those that occur when baseline petroleum fuels are used. The petroleum energy use in all scenarios was restricted to biomass collection and transportation activities, which resulted in a reduction in WTW petroleum energy use of 92-95% relative to that found when baseline petroleum fuels are used. Internal hydrogen production (i.e., via reforming of pyrolysis oil) significantly reduces fossil fuel use and GHG emissions because the hydrogen from fuel gas or pyrolysis oil (renewable sources) displaces that from fossil fuel

  5. ALL-PATHWAYS DOSE ANALYSIS FOR THE PORTSMOUTH ON-SITE WASTE DISPOSAL FACILITY

    SciTech Connect (OSTI)

    Smith, F.; Phifer, M.

    2014-04-10

    A Portsmouth On-Site Waste Disposal Facility (OSWDF) All-Pathways analysis has been conducted that considers the radiological impacts to a resident farmer. It is assumed that the resident farmer utilizes a farm pond contaminated by the OSWDF to irrigate a garden and pasture and water livestock from which food for the resident farmer is obtained, and that the farmer utilizes groundwater from the Berea sandstone aquifer for domestic purposes (i.e. drinking water and showering). As described by FBP 2014b the Hydrologic Evaluation of Landfill Performance (HELP) model (Schroeder et al. 1994) and the Surface Transport Over Multiple Phases (STOMP) model (White and Oostrom 2000, 2006) were used to model the flow and transport from the OSWDF to the Points of Assessment (POAs) associated with the 680-ft elevation sandstone layer (680 SSL) and the Berea sandstone aquifer. From this modeling the activity concentrations radionuclides were projected over time at the POAs. The activity concentrations were utilized as input to a GoldSimTM (GTG 2010) dose model, described herein, in order to project the dose to a resident farmer over time. A base case and five sensitivity cases were analyzed. The sensitivity cases included an evaluation of the impacts of using a conservative inventory, an uncased well to the Berea sandstone aquifer, a low waste zone uranium distribution coefficient (Kd), different transfer factors, and reference person exposure parameters (i.e. at 95 percentile). The maximum base case dose within the 1,000 year assessment period was projected to be 1.5E-14 mrem/yr, and the maximum base case dose at any time less than 10,000 years was projected to be 0.002 mrem/yr. The maximum projected dose of any sensitivity case was approximately 2.6 mrem/yr associated with the use of an uncased well to the Berea sandstone aquifer. This sensitivity case is considered very unlikely because it assumes leakage from the location of greatest concentration in the 680 SSL in to the

  6. SPECIAL ANALYSIS AIR PATHWAY MODELING OF E-AREA LOW-LEVEL WASTE FACILITY

    SciTech Connect (OSTI)

    Hiergesell, R.; Taylor, G.

    2011-08-30

    This Special Analysis (SA) was initiated to address a concern expressed by the Department of Energy's Low Level Waste Disposal Facility Federal Review Group (LFRG) Review Team during their review of the 2008 E-Area Performance Assessment (PA) (WSRC, 2008). Their concern was the potential for overlapping of atmospheric plumes, emanating from the soil surface above SRS LLW disposal facilities within the E-Area, to contribute to the dose received by a member of the public during the Institutional Control (IC) period. The implication of this concern was that the dose to the maximally-exposed individual (MEI) located at the SRS boundary might be underestimated during this time interval. To address this concern a re-analysis of the atmospheric pathway releases from E-Area was required. In the process of developing a new atmospheric release model (ARM) capable of addressing the LFRG plume overlap concern, it became obvious that new and better atmospheric pathway disposal limits should be developed for each of the E-Area disposal facilities using the new ARM. The scope of the SA was therefore expanded to include the generation of these new limits. The initial work conducted in this SA was to develop a new ARM using the GoldSim{reg_sign} program (GTG, 2009). The model simulates the subsurface vapor diffusion of volatile radionuclides as they release from E-Area disposal facility waste zones and migrate to the land surface. In the process of this work, many new features, including several new physical and chemical transport mechanisms, were incorporated into the model. One of the most important improvements was to incorporate a mechanism to partition volatile contaminants across the water-air interface within the partially saturated pore space of the engineered and natural materials through which vapor phase transport occurs. A second mechanism that was equally important was to incorporate a maximum concentration of 1.9E-07 Ci/m{sup 3} of {sup 14}CO{sub 2} in the air

  7. Flux analysis of central metabolic pathways in Geobactermetallireducens during reduction of solubleFe(III)-NTA

    SciTech Connect (OSTI)

    Tang, Yinjie J.; Chakraborty, Romy; Garcia-Martin, Hector; Chu,Jeannie; Hazen, Terry C.; Keasling, Jay D.

    2007-01-01

    We analyzed the carbon fluxes in the central metabolism ofGeobacter metallireducens strain GS-15 using 13C isotopomer modeling.Acetate labeled in the 1st or 2nd position was the sole carbon source,and Fe-NTA was the sole terminal electron acceptor. The measured labeledacetate uptake rate was 21 mmol/gdw/h in the exponential growth phase.The resulting isotope labeling pattern of amino acids allowed an accuratedetermination of the in vivo global metabolic reaction rates (fluxes)through the central metabolic pathways using a computational isotopomermodel. The tracer experiments showed that G. metallireducens containedcomplete biosynthesis pathways for essential metabolism, and this strainmight also have an unusual isoleucine biosynthesis route (usingacetyl-CoA and pyruvate as the precursors). The model indicated that over90 percent of the acetate was completely oxidized to CO2 via a completetricarboxylic acid (TCA) cycle while reducing iron. Pyruvate carboxylaseand phosphoenolpyruvate carboxykinase were present under theseconditions, but enzymes in the glyoxylate shunt and malic enzyme wereabsent. Gluconeogenesis and the pentose phosphate pathway were mainlyemployed for biosynthesis and accounted for less than 3 percent of totalcarbon consumption. The model also indicated surprisingly highreversibility in the reaction between oxoglutarate and succinate. Thisstep operates close to the thermodynamic equilibrium possibly becausesuccinate is synthesized via a transferase reaction, and the conversionof oxoglutarate to succinate is a rate limiting step for carbonmetabolism. These findings enable a better understanding of therelationship between genome annotation and extant metabolic pathways inG. metallireducens.

  8. Comparative genomic analysis of nine Sphingobium strains: Insights into their evolution and hexachlorocyclohexane (HCH) degradation pathways

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Verma, Helianthous; Kumar, Roshan; Oldach, Phoebe; Sangwan, Naseer; Khurana, Jitendra P.; Gilbert, Jack A.; Lal, Rup

    2014-11-23

    Background: Sphingobium spp. are efficient degraders of a wide range of chlorinated and aromatic hydrocarbons. In particular, strains which harbour the lin pathway genes mediating the degradation of hexachlorocyclohexane (HCH) isomers are of interest due to the widespread persistence of this contaminant. Here, we examined the evolution and diversification of the lin pathway under the selective pressure of HCH, by comparing the draft genomes of six newly-sequenced Sphingobium spp. (strains LL03, DS20, IP26, HDIPO4, P25 and RL3) isolated from HCH dumpsites, with three existing genomes (S. indicum B90A, S. japonicum UT26S and Sphingobium sp. SYK6). Results: Efficient HCH degraders phylogeneticallymore » clustered in a closely related group comprising of UT26S, B90A, HDIPO4 and IP26, where HDIPO4 and IP26 were classified as subspecies with ANI value >98%. Less than 10% of the total gene content was shared among all nine strains, but among the eight HCH-associated strains, that is all except SYK6, the shared gene content jumped to nearly 25%. Genes associated with nitrogen stress response and two-component systems were found to be enriched. The strains also housed many xenobiotic degradation pathways other than HCH, despite the absence of these xenobiotics from isolation sources. In addition, these strains, although non-motile, but posses flagellar assembly genes. While strains HDIPO4 and IP26 contained the complete set of lin genes, DS20 was entirely devoid of lin genes (except linKLMN) whereas, LL03, P25 and RL3 were identified as lin deficient strains, as they housed incomplete lin pathways. Further, in HDIPO4, linA was found as a hybrid of two natural variants i.e., linA1 and linA2 known for their different enantioselectivity. In conclusion, the bacteria isolated from HCH dumpsites provide a natural testing ground to study variations in the lin system and their effects on degradation efficacy. Further, the diversity in the lin gene sequences and copy number, their

  9. Waste-to-wheel analysis of anaerobic-digestion-based renewable natural gas pathways with the GREET model.

    SciTech Connect (OSTI)

    Han, J.; Mintz, M.; Wang, M.

    2011-12-14

    In 2009, manure management accounted for 2,356 Gg or 107 billion standard cubic ft of methane (CH{sub 4}) emissions in the United States, equivalent to 0.5% of U.S. natural gas (NG) consumption. Owing to the high global warming potential of methane, capturing and utilizing this methane source could reduce greenhouse gas (GHG) emissions. The extent of that reduction depends on several factors - most notably, how much of this manure-based methane can be captured, how much GHG is produced in the course of converting it to vehicular fuel, and how much GHG was produced by the fossil fuel it might displace. A life-cycle analysis was conducted to quantify these factors and, in so doing, assess the impact of converting methane from animal manure into renewable NG (RNG) and utilizing the gas in vehicles. Several manure-based RNG pathways were characterized in the GREET (Greenhouse gases, Regulated Emissions, and Energy use in Transportation) model, and their fuel-cycle energy use and GHG emissions were compared to petroleum-based pathways as well as to conventional fossil NG pathways. Results show that despite increased total energy use, both fossil fuel use and GHG emissions decline for most RNG pathways as compared with fossil NG and petroleum. However, GHG emissions for RNG pathways are highly dependent on the specifics of the reference case, as well as on the process energy emissions and methane conversion factors assumed for the RNG pathways. The most critical factors are the share of flared controllable CH{sub 4} and the quantity of CH{sub 4} lost during NG extraction in the reference case, the magnitude of N{sub 2}O lost in the anaerobic digestion (AD) process and in AD residue, and the amount of carbon sequestered in AD residue. In many cases, data for these parameters are limited and uncertain. Therefore, more research is needed to gain a better understanding of the range and magnitude of environmental benefits from converting animal manure to RNG via AD.

  10. Pathway and Resource Overview (Presentation)

    SciTech Connect (OSTI)

    Ruth, M. F.

    2009-11-16

    This presentation provides information about hydrogen pathway analysis, which is analysis of the total levelized cost (including return on investment). Well-to-wheels (WTW) energy use, and WTW emissions for hydrogen production, delivery, and distribution pathways.

  11. Integrated analysis of breast cancer cell lines reveals unique signaling pathways

    SciTech Connect (OSTI)

    Heiser, Laura M.; Wang, Nicholas J.; Talcott, Carolyn L.; Laderoute, Keith R.; Knapp, Merrill; Guan, Yinghui; Hu, Zhi; Ziyad, Safiyyah; Weber, Barbara L.; Laquerre, Sylvie; Jackson, Jeffrey R.; Wooster, Richard F.; Kuo, Wen-Lin; Gray, Joe W.; Spellman, Paul T.

    2009-03-31

    Cancer is a heterogeneous disease resulting from the accumulation of genetic defects that negatively impact control of cell division, motility, adhesion and apoptosis. Deregulation in signaling along the EGFR-MAPK pathway is common in breast cancer, though the manner in which deregulation occurs varies between both individuals and cancer subtypes. We were interested in identifying subnetworks within the EGFR-MAPK pathway that are similarly deregulated across subsets of breast cancers. To that end, we mapped genomic, transcriptional and proteomic profiles for 30 breast cancer cell lines onto a curated Pathway Logic symbolic systems model of EGFR-MEK signaling. This model was comprised of 539 molecular states and 396 rules governing signaling between active states. We analyzed these models and identified several subtype specific subnetworks, including one that suggested PAK1 is particularly important in regulating the MAPK cascade when it is over-expressed. We hypothesized that PAK1 overexpressing cell lines would have increased sensitivity to MEK inhibitors. We tested this experimentally by measuring quantitative responses of 20 breast cancer cell lines to three MEK inhibitors. We found that PAK1 over-expressing luminal breast cancer cell lines are significantly more sensitive to MEK inhibition as compared to those that express PAK1 at low levels. This indicates that PAK1 over-expression may be a useful clinical marker to identify patient populations that may be sensitive to MEK inhibitors. All together, our results support the utility of symbolic system biology models for identification of therapeutic approaches that will be effective against breast cancer subsets.

  12. Improved Protein Arrays for Quantitative Systems Analysis of the Dynamics of Signaling Pathway Interactions

    SciTech Connect (OSTI)

    YANG, CHIN-RANG

    2013-12-11

    Astronauts and workers in nuclear plants who repeatedly exposed to low doses of ionizing radiation (IR, <10 cGy) are likely to incur specific changes in signal transduction and gene expression in various tissues of their body. Remarkable advances in high throughput genomics and proteomics technologies enable researchers to broaden their focus from examining single gene/protein kinetics to better understanding global gene/protein expression profiling and biological pathway analyses, namely Systems Biology. An ultimate goal of systems biology is to develop dynamic mathematical models of interacting biological systems capable of simulating living systems in a computer. This Glue Grant is to complement Dr. Boothman’s existing DOE grant (No. DE-FG02-06ER64186) entitled “The IGF1/IGF-1R-MAPK-Secretory Clusterin (sCLU) Pathway: Mediator of a Low Dose IR-Inducible Bystander Effect” to develop sensitive and quantitative proteomic technology that suitable for low dose radiobiology researches. An improved version of quantitative protein array platform utilizing linear Quantum dot signaling for systematically measuring protein levels and phosphorylation states for systems biology modeling is presented. The signals are amplified by a confocal laser Quantum dot scanner resulting in ~1000-fold more sensitivity than traditional Western blots and show the good linearity that is impossible for the signals of HRP-amplification. Therefore this improved protein array technology is suitable to detect weak responses of low dose radiation. Software is developed to facilitate the quantitative readout of signaling network activities. Kinetics of EGFRvIII mutant signaling was analyzed to quantify cross-talks between EGFR and other signaling pathways.

  13. Final Technical Report: Genetic and Molecular Analysis of a new control pathway in assimilate partitioning.

    SciTech Connect (OSTI)

    Bush, Daniel, R.

    2009-03-10

    Assimilate partitioning refers to the systemic distribution of photoassimilate from sites of primary assimilation (source tissue) to import-dependent tissues and organs (sinks). One of the defining questions in this area is how plants balance source productivity with sink demand. We discovered a sucrose-sensing signal transduction pathway that controls the activity of BvSUT1, a proton-sucrose symporter in sugar beet leaf tissue. Sucrose symporters are responsible for sucrose accumulation in the phloem of many plants and, therefore, they mediate the pivotal step in the long-distance transport of photoassimilate to non-photosynthetic tissues, such as roots and seed. We previously showed that sucrose transport activity is directly proportional to the transcription rate of BvSUT1 and that symporter mRNA and protein have high rates of turnover with half-lives on the order of 2 h. We further demonstrated that symporter transcription is regulated by sucrose levels in the leaf and that sucrose-dependent regulation of BvSUT1 transcription is mediated, at least in part, by a protein phosphorylation relay pathway. The goal of the experiments during this current grant were to use genetic and molecular approaches to identify essential components of this vital regulatory system. The initial objectives were to: (1) to characterize Arabidopsis mutants we've isolated that are resistant to growth inhibition by sucrose analogues that are recognized by the sucrose-sensor, (2) to screen for loss of function mutants in BvSUT1-promoter:luciferase transgenic plants that no longer respond to sucrose accumulation in the leaf using non-destructive visualization of luciferase activity, (3) to use gel mobility-shift assays and nuclease protection experiments to identify cis elements in the symporter promoter and DNA-binding proteins that are involved in sucrose regulation of symporter expression.

  14. EVMS Training Snippet: 5.3 PARSII Analysis: Schedule Health Assessment |

    Office of Environmental Management (EM)

    Department of Energy 3 PARSII Analysis: Schedule Health Assessment EVMS Training Snippet: 5.3 PARSII Analysis: Schedule Health Assessment This EVMS Training Snippet, sponsored by the Office of Project Management (PM) is one in a series regarding PARS II Analysis reports. PARS II offers direct insight into EVM project data from the contractor's internal systems. The reports were developed with the users in mind, organized and presented in an easy to follow manner, with analysis results and

  15. Techno-Economic Boundary Analysis of Biological Pathways to Hydrogen Production (2009)

    Broader source: Energy.gov [DOE]

    Presentation by Brian James, Strategic Analysis Inc., at the Biological Hydrogen Production Workshop held September 24-25, 2013, at the National Renewable Energy Laboratory in Golden, Colorado.

  16. Conformational selection in a protein-protein interaction revealed by dynamic pathway analysis

    SciTech Connect (OSTI)

    Chakrabarti, Kalyan S.; Agafonov, Roman V.; Pontiggia, Francesco; Otten, Renee; Higgins, Matthew K.; Schertler, Gebhard F. X.; Oprian, Daniel D.; Kern, Dorothee

    2015-12-24

    Molecular recognition plays a central role in biology, and protein dynamics has been acknowledged to be important in this process. However, it is highly debated whether conformational changes happen before ligand binding to produce a binding-competent state (conformational selection) or are caused in response to ligand binding (induced fit). Proposals for both mechanisms in protein/protein recognition have been primarily based on structural arguments. However, the distinction between them is a question of the probabilities of going via these two opposing pathways. Here we present a direct demonstration of exclusive conformational selection in protein/protein recognition by measuring the flux for rhodopsin kinase binding to its regulator recoverin, an important molecular recognition in the vision system. Using NMR spectroscopy, stopped-flow kinetics and isothermal titration calorimetry we show that recoverin populates a minor conformation in solution that exposes a hydrophobic binding pocket responsible for binding rhodopsin kinase. Lastly, protein dynamics in free recoverin limits the overall rate of binding.

  17. Conformational selection in a protein-protein interaction revealed by dynamic pathway analysis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Chakrabarti, Kalyan S.; Agafonov, Roman V.; Pontiggia, Francesco; Otten, Renee; Higgins, Matthew K.; Schertler, Gebhard F. X.; Oprian, Daniel D.; Kern, Dorothee

    2015-12-24

    Molecular recognition plays a central role in biology, and protein dynamics has been acknowledged to be important in this process. However, it is highly debated whether conformational changes happen before ligand binding to produce a binding-competent state (conformational selection) or are caused in response to ligand binding (induced fit). Proposals for both mechanisms in protein/protein recognition have been primarily based on structural arguments. However, the distinction between them is a question of the probabilities of going via these two opposing pathways. Here we present a direct demonstration of exclusive conformational selection in protein/protein recognition by measuring the flux for rhodopsinmore » kinase binding to its regulator recoverin, an important molecular recognition in the vision system. Using NMR spectroscopy, stopped-flow kinetics and isothermal titration calorimetry we show that recoverin populates a minor conformation in solution that exposes a hydrophobic binding pocket responsible for binding rhodopsin kinase. Lastly, protein dynamics in free recoverin limits the overall rate of binding.« less

  18. Techno-Economic Boundary Analysis of Biological Pathways to Hydrogen Production (2009)

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    September 2013 Presentation to: Biological Hydrogen Production Workshop By: Brian D. James Strategic Analysis Inc. Bjames@sainc.com (703) 778-7114 1 This presentation does not contain any proprietary, confidential, or otherwise restricted information * DOE/NREL Bio H 2 Working Group * Roxanne Garland, DOE * Ali Jalalzadeh-Azar, NREL * Mike Seibert, NREL * Maria Ghirardi, NREL * Pin-Ching Maness, NREL * Tasio Melis, UC Berkeley * Gerald C. Dismukes - Princeton University * Bruce Logan, Penn

  19. Session on computation in biological pathways

    SciTech Connect (OSTI)

    Karp, P.D.; Riley, M.

    1996-12-31

    The papers in this session focus on the development of pathway databases and computational tools for pathway analysis. The discussion involves existing databases of sequenced genomes, as well as techniques for studying regulatory pathways.

  20. EVMS Training Snippet: 5.3 PARSII Analysis: Schedule Health Assessment...

    Office of Environmental Management (EM)

    EVMS Training Snippet: 5.3 PARSII Analysis: Schedule Health Assessment This EVMS Training Snippet, sponsored by the Office of Project Management (PM) is one in a series regarding ...

  1. National Dialogue on Career Pathways

    Broader source: Energy.gov [DOE]

    On Tuesday, September 23, 2014, the U.S. Departments of Labor, Education and Health and Human Services will host a National Dialogue on Career Pathways.  Federal agency leaders from each Department...

  2. An analysis of uranium dispersal and health effects using a Gulf War case study.

    SciTech Connect (OSTI)

    Marshall, Albert Christian

    2005-07-01

    The study described in this report used mathematical modeling to estimate health risks from exposure to depleted uranium (DU) during the 1991 Gulf War for both U.S. troops and nearby Iraqi civilians. The analysis found that the risks of DU-induced leukemia or birth defects are far too small to result in an observable increase in these health effects among exposed veterans or Iraqi civilians. Only a few veterans in vehicles accidentally struck by U.S. DU munitions are predicted to have inhaled sufficient quantities of DU particulate to incur any significant health risk (i.e., the possibility of temporary kidney damage from the chemical toxicity of uranium and about a 1% chance of fatal lung cancer). The health risk to all downwind civilians is predicted to be extremely small. Recommendations for monitoring are made for certain exposed groups. Although the study found fairly large calculational uncertainties, the models developed and used are generally valid. The analysis was also used to assess potential uranium health hazards for workers in the weapons complex. No illnesses are projected for uranium workers following standard guidelines; nonetheless, some research suggests that more conservative guidelines should be considered.

  3. Comparative genomic analysis of nine Sphingobium strains: Insights into their evolution and hexachlorocyclohexane (HCH) degradation pathways

    SciTech Connect (OSTI)

    Verma, Helianthous; Kumar, Roshan; Oldach, Phoebe; Sangwan, Naseer; Khurana, Jitendra P.; Gilbert, Jack A.; Lal, Rup

    2014-11-23

    Background: Sphingobium spp. are efficient degraders of a wide range of chlorinated and aromatic hydrocarbons. In particular, strains which harbour the lin pathway genes mediating the degradation of hexachlorocyclohexane (HCH) isomers are of interest due to the widespread persistence of this contaminant. Here, we examined the evolution and diversification of the lin pathway under the selective pressure of HCH, by comparing the draft genomes of six newly-sequenced Sphingobium spp. (strains LL03, DS20, IP26, HDIPO4, P25 and RL3) isolated from HCH dumpsites, with three existing genomes (S. indicum B90A, S. japonicum UT26S and Sphingobium sp. SYK6). Results: Efficient HCH degraders phylogenetically clustered in a closely related group comprising of UT26S, B90A, HDIPO4 and IP26, where HDIPO4 and IP26 were classified as subspecies with ANI value >98%. Less than 10% of the total gene content was shared among all nine strains, but among the eight HCH-associated strains, that is all except SYK6, the shared gene content jumped to nearly 25%. Genes associated with nitrogen stress response and two-component systems were found to be enriched. The strains also housed many xenobiotic degradation pathways other than HCH, despite the absence of these xenobiotics from isolation sources. In addition, these strains, although non-motile, but posses flagellar assembly genes. While strains HDIPO4 and IP26 contained the complete set of lin genes, DS20 was entirely devoid of lin genes (except linKLMN) whereas, LL03, P25 and RL3 were identified as lin deficient strains, as they housed incomplete lin pathways. Further, in HDIPO4, linA was found as a hybrid of two natural variants i.e., linA1 and linA2 known for their different enantioselectivity. In conclusion, the bacteria isolated from HCH dumpsites provide a natural testing ground to study variations in the lin system and their

  4. Well-to-Wheels analysis of landfill gas-based pathways and their addition to the GREET model.

    SciTech Connect (OSTI)

    Mintz, M.; Han, J.; Wang, M.; Saricks, C.; Energy Systems

    2010-06-30

    Today, approximately 300 million standard cubic ft/day (mmscfd) of natural gas and 1600 MW of electricity are produced from the decomposition of organic waste at 519 U.S. landfills (EPA 2010a). Since landfill gas (LFG) is a renewable resource, this energy is considered renewable. When used as a vehicle fuel, compressed natural gas (CNG) produced from LFG consumes up to 185,000 Btu of fossil fuel and generates from 1.5 to 18.4 kg of carbon dioxide-equivalent (CO{sub 2}e) emissions per million Btu of fuel on a 'well-to-wheel' (WTW) basis. This compares with approximately 1.1 million Btu and 78.2 kg of CO{sub 2}e per million Btu for CNG from fossil natural gas and 1.2 million Btu and 97.5 kg of CO{sub 2}e per million Btu for petroleum gasoline. Because of the additional energy required for liquefaction, LFG-based liquefied natural gas (LNG) requires more fossil fuel (222,000-227,000 Btu/million Btu WTW) and generates more GHG emissions (approximately 22 kg CO{sub 2}e /MM Btu WTW) if grid electricity is used for the liquefaction process. However, if some of the LFG is used to generate electricity for gas cleanup and liquefaction (or compression, in the case of CNG), vehicle fuel produced from LFG can have no fossil fuel input and only minimal GHG emissions (1.5-7.7 kg CO{sub 2}e /MM Btu) on a WTW basis. Thus, LFG-based natural gas can be one of the lowest GHG-emitting fuels for light- or heavy-duty vehicles. This report discusses the size and scope of biomethane resources from landfills and the pathways by which those resources can be turned into and utilized as vehicle fuel. It includes characterizations of the LFG stream and the processes used to convert low-Btu LFG into high-Btu renewable natural gas (RNG); documents the conversion efficiencies and losses of those processes, the choice of processes modeled in GREET, and other assumptions used to construct GREET pathways; and presents GREET results by pathway stage. GREET estimates of well-to-pump (WTP), pump

  5. Integrated analysis reveals that STAT3 is central to the crosstalk between HER/ErbB receptor signaling pathways in human mammary epithelial cells

    SciTech Connect (OSTI)

    Gong, Chunhong; Zhang, Yi; Shankaran, Harish; Resat, Haluk

    2015-01-01

    Human epidermal growth factor receptors (HER, also known as ErbB) drive cellular proliferation, pro-survival and stress responses by activating several downstream kinases, in particular ERK, p38, JNK (SAPK), the PI3K/AKT, as well as various transcriptional regulators such as STAT3. When co-expressed, first three members of HER family (HER1-3) can form homo- and hetero-dimers. Based on the considerable evidence which suggest that every receptor dimer activates intracellular signaling pathways differentially, we hypothesized that the HER dimerization pattern is a better predictor of downstream signaling than the total receptor activation levels. We validated our hypothesis using a combination of model-based analysis to quantify the HER dimerization patterns and multi-factorial experiments where HER dimerization patterns and signaling crosstalk were rationally perturbed. We have measured the activation of HER1-3 receptors and of the sentinel signaling proteins ERK, AKT, p38, JNK, STAT3 as a function of time in a panel of human mammary epithelial (HME) cells expressing different levels of HER1-3 stimulated with various ligand combinations. Our analysis using multiple ways of clustering the activation data has confirmed that the HER receptor dimer is a better predictor of the signaling through p38, ERK and AKT pathways than the total HER receptor expression and activation levels. Targeted inhibition studies to identify the causal effects allowed us to obtain a consensus regulatory interaction model, which revealed that STAT3 occupies a central role in the crosstalk between the studied pathways.

  6. Integrated analysis reveals that STAT3 is central to the crosstalk between HER/ErbB receptor signaling pathways in human mammary epithelial cells

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Gong, Chunhong; Zhang, Yi; Shankaran, Harish; Resat, Haluk

    2014-10-02

    Human epidermal growth factor receptors (HER, also known as ErbB) drive cellular proliferation, pro-survival and stress responses by activating several downstream kinases, in particular ERK, p38, JNK (SAPK), the PI3K/AKT, as well as various transcriptional regulators such as STAT3. When co-expressed, first three members of HER family (HER1-3) can form homo- and hetero-dimers. Based on the considerable evidence which suggest that every receptor dimer activates intracellular signaling pathways differentially, we hypothesized that the HER dimerization pattern is a better predictor of downstream signaling than the total receptor activation levels. We validated our hypothesis using a combination of model-based analysis tomore » quantify the HER dimerization patterns and multi-factorial experiments where HER dimerization patterns and signaling crosstalk were rationally perturbed. We have measured the activation of HER1-3 receptors and of the sentinel signaling proteins ERK, AKT, p38, JNK, STAT3 as a function of time in a panel of human mammary epithelial (HME) cells expressing different levels of HER1-3 stimulated with various ligand combinations. Our analysis using multiple ways of clustering the activation data has confirmed that the HER receptor dimer is a better predictor of the signaling through p38, ERK and AKT pathways than the total HER receptor expression and activation levels. Targeted inhibition studies to identify the causal effects allowed us to obtain a consensus regulatory interaction model, which revealed that STAT3 occupies a central role in the crosstalk between the studied pathways.« less

  7. Metabolic analysis of the soil microbe Dechloromonas aromatica str. RCB: indications of a surprisingly complex life-style and cryptic anaerobic pathways for aromatic degradation

    SciTech Connect (OSTI)

    Salinero, Kennan Kellaris; Keller, Keith; Feil, William S.; Feil, Helene; Trong, Stephan; Di Bartolo, Genevieve; Lapidus, Alla

    2008-11-17

    Initial interest in Dechloromonas aromatica strain RCB arose from its ability to anaerobically degrade benzene. It is also able to reduce perchlorate and oxidize chlorobenzoate, toluene, and xylene, creating interest in using this organism for bioremediation. Little physiological data has been published for this microbe. It is considered to be a free-living organism. The a priori prediction that the D. aromatica genome would contain previously characterized 'central' enzymes involved in anaerobic aromatic degradation proved to be false, suggesting the presence of novel anaerobic aromatic degradation pathways in this species. These missing pathways include the benzyl succinyl synthase (bssABC) genes (responsible for formate addition to toluene) and the central benzoylCoA pathway for monoaromatics. In depth analyses using existing TIGRfam, COG, and InterPro models, and the creation of de novo HMM models, indicate a highly complex lifestyle with a large number of environmental sensors and signaling pathways, including a relatively large number of GGDEF domain signal receptors and multiple quorum sensors. A number of proteins indicate interactions with an as yet unknown host, as indicated by the presence of predicted cell host remodeling enzymes, effector enzymes, hemolysin-like proteins, adhesins, NO reductase, and both type III and type VI secretory complexes. Evidence of biofilm formation including a proposed exopolysaccharide complex with the somewhat rare exosortase (epsH), is also present. Annotation described in this paper also reveals evidence for several metabolic pathways that have yet to be observed experimentally, including a sulphur oxidation (soxFCDYZAXB) gene cluster, Calvin cycle enzymes, and nitrogen fixation (including RubisCo, ribulose-phosphate 3-epimerase, and nif gene families, respectively). Analysis of the D. aromatica genome indicates there is much to be learned regarding the metabolic capabilities, and life-style, for this microbial species

  8. Density Functional Theory Calculations and Analysis of Reaction Pathways for Reduction of Nitric Oxide by Hydrogen on Pt(111)

    SciTech Connect (OSTI)

    Farberow, Carrie A.; Dumesic, James A.; Mavrikakis, Manos

    2014-10-03

    Reaction pathways are explored for low temperature (e.g., 400 K) reduction of nitric oxide by hydrogen on Pt(111). First-principles electronic structure calculations based on periodic, self-consistent density functional theory(DFT-GGA, PW91) are employed to obtain thermodynamic and kinetic parameters for proposed reaction schemes on Pt(111). The surface of Pt(111) during NO reduction by H? at low temperatures is predicted to operate at a high NO coverage, and this environment is explicitly taken into account in the DFT calculations. Maximum rate analyses are performed to assess the most likely reaction mechanisms leading to formation of N?O, the major product observed experimentally at low temperatures. The results of these analyses suggest that the reaction most likely proceeds via the addition of at least two H atoms to adsorbed NO, followed by cleavage of the N-O bond.

  9. Needs analysis and project schedule for the Los Alamos National Laboratory (LANL) Health Physics Analysis Laboratory (HPAL) upgrade

    SciTech Connect (OSTI)

    Rhea, T.A.; Rucker, T.L.; Stafford, M.W.

    1990-09-28

    This report is a needs assessment and project schedule for the Health Physics Analysis Laboratory (HPAL) upgrade project at Los Alamos National Laboratory (LANL). After reviewing current and projected HPAL operations, two custom-developed laboratory information management systems (LIMS) for similar facilities were reviewed; four commercially available LIMS products were also evaluated. This project is motivated by new regulations for radiation protection and training and by increased emphasis on quality assurance (QA). HPAL data are used to: protect the health of radiation workers; document contamination levels for transportation of radioactive materials and for release of materials to the public for uncontrolled use; and verify compliance with environmental emission regulations. Phase 1 of the HPAL upgrade project concentrates on four types of counting instruments which support in excess of 90% of the sample workload at the existing central laboratories. Phase 2 is a refinement phase and also integrates summary-level databases on the central Health, Safety, and Environment (HSE) VAX. Phase 3 incorporates additional instrument types and integrates satellite laboratories into the HPAL LIMS. Phase 1 will be a multi-year, multimillion dollar project. The temptation to approach the upgrade of the HPAL program in a piece meal fashion should be avoided. This is a major project, with clearly-defined goals and priorities, and should be approached as such. Major programmatic and operational impacts will be felt throughout HSE as a result of this upgrade, so effective coordination with key customer contacts will be critical.

  10. Exposure Based Health Issues Project Report: Phase I of High Level Tank Operations, Retrieval, Pretreatment, and Vitrification Exposure Based Health Issues Analysis

    SciTech Connect (OSTI)

    Stenner, Robert D.; Bowers, Harold N.; Kenoyer, Judson L.; Strenge, Dennis L.; Brady, William H.; Ladue, Buffi; Samuels, Joseph K.

    2001-11-30

    The Department of Energy (DOE) has the responsibility to understand the ''big picture'' of worker health and safety which includes fully recognizing the vulnerabilities and associated programs necessary to protect workers at the various DOE sites across the complex. Exposure analysis and medical surveillance are key aspects for understanding this big picture, as is understanding current health and safety practices and how they may need to change to relate to future health and safety management needs. The exposure-based health issues project was initiated to assemble the components necessary to understand potential exposure situations and their medical surveillance and clinical aspects. Phase I focused only on current Hanford tank farm operations and serves as a starting point for the overall project. It is also anticipated that once the pilot is fully developed for Hanford HLW (i.e., current operations, retrieval, pretreatment, vitrification, and disposal), the process and analysis methods developed will be available and applicable for other DOE operations and sites. The purpose of this Phase I project report is to present the health impact information collected regarding ongoing tank waste maintenance operations, show the various aspects of health and safety involved in protecting workers, introduce the reader to the kinds of information that will need to be analyzed in order to effectively manage worker safety.

  11. Health effects model for nuclear power plant accident consequence analysis. Part I. Introduction, integration, and summary. Part II. Scientific basis for health effects models

    SciTech Connect (OSTI)

    Evans, J.S.; Moeller, D.W.; Cooper, D.W.

    1985-07-01

    Analysis of the radiological health effects of nuclear power plant accidents requires models for predicting early health effects, cancers and benign thyroid nodules, and genetic effects. Since the publication of the Reactor Safety Study, additional information on radiological health effects has become available. This report summarizes the efforts of a program designed to provide revised health effects models for nuclear power plant accident consequence modeling. The new models for early effects address four causes of mortality and nine categories of morbidity. The models for early effects are based upon two parameter Weibull functions. They permit evaluation of the influence of dose protraction and address the issue of variation in radiosensitivity among the population. The piecewise-linear dose-response models used in the Reactor Safety Study to predict cancers and thyroid nodules have been replaced by linear and linear-quadratic models. The new models reflect the most recently reported results of the follow-up of the survivors of the bombings of Hiroshima and Nagasaki and permit analysis of both morbidity and mortality. The new models for genetic effects allow prediction of genetic risks in each of the first five generations after an accident and include information on the relative severity of various classes of genetic effects. The uncertainty in modeloling radiological health risks is addressed by providing central, upper, and lower estimates of risks. An approach is outlined for summarizing the health consequences of nuclear power plant accidents. 298 refs., 9 figs., 49 tabs.

  12. SRNL ALL-PATHWAYS APPLICATION

    SciTech Connect (OSTI)

    Koffman, L; Elmer Wilhite, E; Leonard Collard, L

    2007-05-29

    The Environmental Analysis and Performance Modeling group of Savannah River National Laboratory (SRNL) performs performance assessments of the Savannah River Site (SRS) low-level waste facilities to meet the requirements of DOE Order 435.1. One of the performance objectives in the DOE Order is that the radiological dose to representative members of the public shall not exceed 25 mrem in a year total effective dose equivalent from all exposure pathways, excluding radon. Analysis to meet this performance objective is generally referred to as all-pathways analysis. SRNL performs detailed transient groundwater transport analysis for the waste disposal units, which has been used as input for the groundwater part of all-pathways analysis. The desire to better integrate all-pathways analysis with the groundwater transport analysis lead to the development of a software application named the SRNL All-Pathways Application. Another requirement of DOE Order 435.1 is to assess the impact of nuclear waste disposal on water resources, which SRS has interpreted for groundwater protection as meeting the EPA regulations for radionuclides in drinking water. EPA specifies four separate criteria as part of their implementation guidance for radionuclides, which are specified as maximum contaminant levels (MCL). (1) Beta/gamma emitters have a combined dose limit of 4 mrem/year. (2) Alpha emitters have a combined concentration limit of 15 pCi/L (called gross alpha), excluding uranium and radon, but including radium-226. (3) Combined radium-226 and radium-228 have a concentration limit of 5 pCi/L. (4) Isotopes of uranium have a combined concentration limit of 30 {micro}g/L. The All-Pathways Application was designed to be an easy-to-use software application that utilizes transient concentration results from groundwater transport analysis to (1) calculate the groundwater part of all-pathways dose and to (2) evaluate the four EPA criteria for groundwater protection.

  13. Engineering ESPT Pathways Based on Structural Analysis of LSSmKate Red Fluorescent Proteins with Large Stokes Shift

    SciTech Connect (OSTI)

    Piatkevich, K.; Malashkevich, V; Almo, S; Verkhusha, V

    2010-01-01

    LSSmKate1 and LSSmKate2 are monomeric red fluorescent proteins (RFPs) with large Stokes shifts (LSSs), which allows for efficient separation of absorbance and emission maxima, as well as for excitation with conventional two-photon laser sources. These LSSmKates differ by a single amino acid substitution at position 160 and exhibit absorbance maxima around 460 nm, corresponding to a neutral DsRed-like chromophore. However, excitation at 460 nm leads to fluorescence emission above 600 nm. Structures of LSSmKate1 and LSSmKate2, determined at resolutions of 2.0 and 1.5 {angstrom}, respectively, revealed that the predominant DsRed-chromophore configurations are cis for LSSmKate1 but trans for LSSmKate2. Crystallographic and mutagenesis analyses, as well as isotope and temperature dependences, suggest that an excited-state proton transfer (ESPT) is responsible for the LSSs observed in LSSmKates. Hydrogen bonding between the chromophore hydroxyl and Glu160 in LSSmKate1 and a proton relay involving the chromophore tyrosine hydroxyl, Ser158, and the Asp160 carboxylate in LSSmKate2 represent the putative ESPT pathways. Comparisons with mKeima LSS RFP suggest that similar proton relays could be engineered in other FPs. Accordingly, we mutated positions 158 and 160 in several conventional red-shifted FPs, including mNeptune, mCherry, mStrawberry, mOrange, and mKO, and the resulting FP variants exhibited LSS fluorescence emission in a wide range of wavelengths from 560 to 640 nm. These data suggest that different chromophores formed by distinct tripeptides in different environments can be rationally modified to yield RFPs with novel photochemical properties.

  14. Method of assessing a lipid-related health risk based on ion mobility analysis of lipoproteins

    DOE Patents [OSTI]

    Benner, W. Henry; Krauss, Ronald M.; Blanche, Patricia J.

    2010-12-14

    A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.

  15. Fuel Pathways Integration Tech Team | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathways Integration Tech Team Fuel Pathways Integration Tech Team Presentation on Fuel Pathways Integration Tech Team to the DOE Systems Analysis Workshop held in Washington, D.C. July 28-29, 2004. 8_fpitt_gardner.pdf (109.24 KB) More Documents & Publications Systems Analysis Workshop Agenda Hydrogen Analysis Analysis Activities at National Renewable Energy Laboratory

  16. Future prospects for compression ignition fuel in California : fuel-related implications of possible pathways to mitigation of public health threats.

    SciTech Connect (OSTI)

    Eberhardt, J. J.; Rote, D. M.; Saricks, C. L.; Stodolsky, F.

    1999-04-08

    This paper documents methods and results of an investigation of the options for and year 2010 consequences of possible new limitations on the use of diesel fuel in California, USA. California's Air Resources Board will undertake a risk management process to determine steps necessary to protect the health and safety of the public from carcinogenic species resident on diesel combustion exhaust particles. Environmental activist groups continue to call for the elimination of diesel fuel in California and other populous states. It is the declared intention of CARB not to ban or restrict diesel fuel, per se, at this time. Thus, two ''mid-course'' strategies now appear feasible: (1) Increased penetration of natural gas, LPG, and possibly lower alcohols into the transportation fuels market, to the extent that some Cl applications would revert to spark-ignition (SI) engines. (2) New specifications requiring diesel fuel reformulation based on more detailed investigation of exhaust products of individual diesel fuel constituents.

  17. Pathways and transformations of dissolved methane and dissolved inorganic carbon in Arctic tundra watersheds: Evidence from analysis of stable isotopes

    SciTech Connect (OSTI)

    Throckmorton, Heather M.; Heikoop, Jeffrey M.; Newman, Brent D.; Altmann, Garrett L.; Conrad, Mark S.; Muss, Jordan D.; Perkins, George B.; Smith, Lydia J.; Torn, Margaret S.; Wullschleger, Stan D.; Wilson, Cathy J.

    2015-11-08

    Arctic soils contain a large pool of terrestrial C and are of interest due to their potential for releasing significant carbon dioxide (CO2) and methane (CH4) to the atmosphere. Due to substantial landscape heterogeneity, predicting ecosystem-scale CH4 and CO2 production is challenging. This study assessed dissolved inorganic carbon (DIC = Σ (total) dissolved CO2) and CH4 in watershed drainages in Barrow, Alaska as critical convergent zones of regional geochemistry, substrates, and nutrients. In July and September of 2013, surface waters and saturated subsurface pore waters were collected from 17 drainages. Based on simultaneous DIC and CH4 cycling, we synthesized isotopic and geochemical methods to develop a subsurface CH4 and DIC balance by estimating mechanisms of CH4 and DIC production and transport pathways and oxidation of subsurface CH4. We observed a shift from acetoclastic (July) toward hydrogenotropic (September) methanogenesis at sites located toward the end of major freshwater drainages, adjacent to salty estuarine waters, suggesting an interesting landscape-scale effect on CH4 production mechanism. The majority of subsurface CH4 was transported upward by plant-mediated transport and ebullition, predominantly bypassing the potential for CH4 oxidation. Thus, surprisingly, CH4 oxidation only consumed approximately 2.51± 0.82% (July) and 0.79 ± 0.79% (September) of CH4 produced at the frost table, contributing to <0.1% of DIC production. DIC was primarily produced from respiration, with iron and organic matter serving as likely e- acceptors. Furthermore, this work highlights the importance of spatial and temporal variability of CH4 production at the watershed scale and suggests broad scale investigations are required to build better regional or pan-Arctic representations of CH

  18. Microsoft PowerPoint - Snippet 5.3 PARSII Analysis Schedule Health...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... some subtle differences as compared to the results using other software programs to run schedule health metrics; for example, running the same types of schedule health checks on ...

  19. Probabilistic accident consequence uncertainty analysis -- Late health effects uncertain assessment. Volume 2: Appendices

    SciTech Connect (OSTI)

    Little, M.P.; Muirhead, C.R.; Goossens, L.H.J.; Kraan, B.C.P.; Cooke, R.M.; Harper, F.T.; Hora, S.C.

    1997-12-01

    The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library of uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA late health effects models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the expert panel on late health effects, (4) short biographies of the experts, and (5) the aggregated results of their responses.

  20. Probabilistic accident consequence uncertainty analysis -- Early health effects uncertainty assessment. Volume 2: Appendices

    SciTech Connect (OSTI)

    Haskin, F.E.; Harper, F.T.; Goossens, L.H.J.; Kraan, B.C.P.

    1997-12-01

    The development of two new probabilistic accident consequence codes, MACCS and COSYMA, was completed in 1990. These codes estimate the consequence from the accidental releases of radiological material from hypothesized accidents at nuclear installations. In 1991, the US Nuclear Regulatory Commission and the Commission of the European Communities began cosponsoring a joint uncertainty analysis of the two codes. The ultimate objective of this joint effort was to systematically develop credible and traceable uncertainty distributions for the respective code input variables. A formal expert judgment elicitation and evaluation process was identified as the best technology available for developing a library of uncertainty distributions for these consequence parameters. This report focuses on the results of the study to develop distribution for variables related to the MACCS and COSYMA early health effects models. This volume contains appendices that include (1) a summary of the MACCS and COSYMA consequence codes, (2) the elicitation questionnaires and case structures, (3) the rationales and results for the panel on early health effects, (4) short biographies of the experts, and (5) the aggregated results of their responses.

  1. What are pathways?

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    body. For the inhalation or airborne pathway, a material is inhaled directly into the lungs and then moves into the bloodstream. For the ingestion pathway, there are several...

  2. Analysis and comparison of five contractor safety and health manuals (EG and G, SR II, ORNL, Ashland, and MLGW)

    SciTech Connect (OSTI)

    Crowder, C.; Hurley, T.

    1981-03-01

    An analysis is presented of five safety and health contractor manuals against the requirements of the FE OSH Manual (FE 5480.1), and a breakdown in chart form of how the manuals compare to each other is given. It is pointed out that the manuals are inadequate, but that site visits will be necessary to determine the actual comprehensiveness of the facilities' safety and health programs.

  3. Worker Safety and Health and Nuclear Safety Quarterly Performance Analysis (January - March 2008)

    SciTech Connect (OSTI)

    Kerr, C E

    2009-10-07

    The DOE Office of Enforcement expects LLNL to 'implement comprehensive management and independent assessments that are effective in identifying deficiencies and broader problems in safety and security programs, as well as opportunities for continuous improvement within the organization' and to 'regularly perform assessments to evaluate implementation of the contractor's processes for screening and internal reporting.' LLNL has a self-assessment program, described in ES&H Manual Document 4.1, that includes line, management and independent assessments. LLNL also has in place a process to identify and report deficiencies of nuclear, worker safety and health and security requirements. In addition, the DOE Office of Enforcement expects LLNL to evaluate 'issues management databases to identify adverse trends, dominant problem areas, and potential repetitive events or conditions' (page 14, DOE Enforcement Process Overview, December 2007). LLNL requires that all worker safety and health and nuclear safety noncompliances be tracked as 'deficiencies' in the LLNL Issues Tracking System (ITS). Data from the ITS are analyzed for worker safety and health (WSH) and nuclear safety noncompliances that may meet the threshold for reporting to the DOE Noncompliance Tracking System (NTS). This report meets the expectations defined by the DOE Office of Enforcement to review the assessments conducted by LLNL, analyze the issues and noncompliances found in these assessments, and evaluate the data in the ITS database to identify adverse trends, dominant problem areas, and potential repetitive events or conditions. The report attempts to answer three questions: (1) Is LLNL evaluating its programs and state of compliance? (2) What is LLNL finding? (3) Is LLNL appropriately managing what it finds? The analysis in this report focuses on data from the first quarter of 2008 (January through March). This quarter is analyzed within the context of information identified in previous quarters to

  4. Analysis of Potential Leakage Pathways and Mineralization within Caprocks for Geologic Storage of CO2

    SciTech Connect (OSTI)

    Evans, James

    2013-05-01

    normal faults in the Permian Cedar Mesa Sandstone, southeastern Utah. These faults are characterized by a single slip surfaces and damage zones containing deformation bands, veins, and joints. Field observations include crosscutting relationships, permeability increase, rock strength decrease, and ultraviolet light induced mineral fluorescence within the damage zone. These field observations combined with the interpreted paragenetic sequence from petrographic analysis, suggests a deformation history of reactivation and several mineralization events in an otherwise low-permeability fault. All deformation bands and veins fluoresce under ultraviolet light, suggesting connectivity and a shared mineralization history. Pre-­existing deformation features act as loci for younger deformation and mineralization events, this fault and its damage zone illustrate the importance of the fault damage zone to subsurface fluid flow. We model a simplified stress history in order to understand the importance of rock properties and magnitude of tectonic stress on the deformation features within the damage zone. The moderate confining pressures, possible variations in pore pressure, and the porous, fine-­grained nature of the Cedar Mesa Sandstone results in a fault damage zone characterized by enhanced permeability, subsurface fluid flow, and mineralization. Structural setting greatly influences fracture spacing and orientation. Three structural settings were examined and include fault proximity, a fold limb of constant dip, and a setting proximal to the syncline hinge. Fracture spacing and dominant fracture orientation vary at each setting and distinctions between regional and local paleo-stress directions can be made. Joints on the fold limb strike normal to the fold axis/bedding and are interpreted to be sub-parallel to the maximum regional paleo-stress direction as there is no fold related strain. Joints proximal to faults and the syncline hinge may have formed under local stress

  5. A New Pathway for Radionuclide Uptake

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A New Pathway for Radionuclide Uptake A New Pathway for Radionuclide Uptake Print Thursday, 21 January 2016 12:40 Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, present severe health threats as contaminants, and understanding the scope of the biochemical interactions involved in actinide uptake into cells is instrumental in managing human contamination. Recently, scientists have reported that an iron-binding protein called siderocalin can also bind

  6. Hydrogen Pathway Cost Distributions

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathway Cost Distributions Jim Uihlein Fuel Pathways Integration Tech Team January 25, 2006 2 Outline * Pathway-Independent Cost Goal * Cost Distribution Objective * Overview * H2A Influence * Approach * Implementation * Results * Discussion Process * Summary 3 Hydrogen R&D Cost Goal * Goal is pathway independent * Developed through a well defined, transparent process * Consumer fueling costs are equivalent or less on a cents per mile basis * Evolved gasoline ICE and gasoline-electric

  7. Pathway and Resource Overview | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    and Resource Overview Pathway and Resource Overview Presented at the Renewable Hydrogen Workshop, Nov. 16, 2009, in Palm Springs, CA renewable_hydrogen_workshop_nov16_ruth.pdf (684.83 KB) More Documents & Publications US DOE Hydrgoen Program- HyDRA (Hydrogen Demand and Resource Analysis Tool Hydrogen Pathways: Cost, Well-to-Wheels Energy Use, and Emissions for the Current Technology Status of Seven Hydrogen Production, Delivery, and Distribution Scenarios Analysis Models and Tools: Systems

  8. ORISE: Health Physics Training

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health Physics Training Student performs an analysis during an ORAU health physics training course Training and educating a highly skilled workforce that can meet operational ...

  9. Aquatic pathways model to predict the fate of phenolic compounds

    SciTech Connect (OSTI)

    Aaberg, R.L.; Peloquin, R.A.; Strenge, D.L.; Mellinger, P.J.

    1983-04-01

    Organic materials released from energy-related activities could affect human health and the environment. To better assess possible impacts, we developed a model to predict the fate of spills or discharges of pollutants into flowing or static bodies of fresh water. A computer code, Aquatic Pathways Model (APM), was written to implement the model. The computer programs use compartmental analysis to simulate aquatic ecosystems. The APM estimates the concentrations of chemicals in fish tissue, water and sediment, and is therefore useful for assessing exposure to humans through aquatic pathways. The APM will consider any aquatic pathway for which the user has transport data. Additionally, APM will estimate transport rates from physical and chemical properties of chemicals between several key compartments. The major pathways considered are biodegradation, fish and sediment uptake, photolysis, and evaporation. The model has been implemented with parameters for distribution of phenols, an important class of compounds found in the water-soluble fractions of coal liquids. Current modeling efforts show that, in comparison with many pesticides and polyaromatic hydrocarbons (PAH), the lighter phenolics (the cresols) are not persistent in the environment. The properties of heavier molecular weight phenolics (indanols, naphthols) are not well enough understood at this time to make similar judgements. For the twelve phenolics studied, biodegradation appears to be the major pathway for elimination from aquatic environments. A pond system simulation (using APM) of a spill of solvent refined coal (SRC-II) materials indicates that phenol, cresols, and other single cyclic phenolics are degraded to 16 to 25 percent of their original concentrations within 30 hours. Adsorption of these compounds into sediments and accumulation by fish was minor.

  10. Technology Pathway Selection Effort

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    BIOMASS PROGRAM Technology Pathway Selection Effort Alicia Lindauer 27 November 2012 2 | Biomass Program eere.energy.gov * Setting R&D priorities * Benchmarking * Informing multi-sectoral analytical activities * Track Program R&D progress against goals * Identify technology process routes and prioritize funding * Program direction decisions: * Are we spending our money on the right technology pathways? * Within a pathway: Are we focusing our funding on the highest priority activities?

  11. 2010 Annual Workforce Analysis and Staffing Plan Report- Office of Health, Safety and Security

    Broader source: Energy.gov [DOE]

    Managers perform an annual workforce analysis of their organization and develop staffing plans that identify technical capabilities and positions they need to ensure safe operation of defense nuclear facilities.

  12. 2015 Annual Workforce Analysis and Staffing Plan Report- Office of Environment, Health, Safety and Security

    Broader source: Energy.gov [DOE]

    Managers perform an annual workforce analysis of their organization and develop staffing plans that identify technical capabilities and positions they need to ensure safe operation of defense nuclear facilities.

  13. 2014 Annual Workforce Analysis and Staffing Plan Report- Office of Environment, Health, Safety and Security

    Broader source: Energy.gov [DOE]

    Managers perform an annual workforce analysis of their organization and develop staffing plans that identify technical capabilities and positions they need to ensure safe operation of defense nuclear facilities.

  14. 2013 Annual Workforce Analysis and Staffing Plan Report- Office of Health, Safety and Security

    Broader source: Energy.gov [DOE]

    Managers perform an annual workforce analysis of their organization and develop staffing plans that identify technical capabilities and positions they need to ensure safe operation of defense nuclear facilities.

  15. 2011 Annual Workforce Analysis and Staffing Plan Report- Office of Health, Safety and Security

    Broader source: Energy.gov [DOE]

    Managers perform an annual workforce analysis of their organization and develop staffing plans that identify technical capabilities and positions they need to ensure safe operation of defense nuclear facilities.

  16. 2012 Annual Workforce Analysis and Staffing Plan Report- Office of Health, Safety and Security

    Broader source: Energy.gov [DOE]

    Managers perform an annual workforce analysis of their organization and develop staffing plans that identify technical capabilities and positions they need to ensure safe operation of defense nuclear facilities.

  17. Sustainability & Strategic Analysis

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ... Technologies Office * Design cases of biofuel pathways * Environmental sustainability metrics for conversion stage * GREET analysis of full pathway to identify drivers of GHG ...

  18. Technical and Analytical Support Services to the Office of Environmental Analysis, Office of Environment, Safety and Health. Final report

    SciTech Connect (OSTI)

    1995-02-01

    The primary purpose of this contract was to provide technical analyses, studies, and reviews related to land use/water issues and energy resource development in support of the activities of the Office of Environmental Analysis, Office of Environment, Safety and Health. Tasks under this contract included: Issue Papers. Energetics provided issue papers on a number of specific energy and environmental issue areas. Each issue paper consisted of a systematic review and analysis of major factors (technical, legal, environmental, economic, energy, health and social) that could enter into DOE`s environmental/energy policy decisions; Special Analyses. Energetics conducted special in-depth technical analyses as requested by the Contracting Officer`s Technical Representative (COTR); and Critical Review and Evaluation of Program Reports. Energetics performed critical reviews of a number of technical reports arising from DOE program activities. These documents included issue papers and reports resulting from special technical analyses of specific issues, technologies, or broad areas of concern. Reviews focused on both the technical and programmatic impact of the report. Energetics made recommendations and gave input to assist DOE in determining the environmental impacts of energy policies and projects.

  19. Solar Market Pathways

    Broader source: Energy.gov [DOE]

    The Solar Market Pathways website distributes key insights from 15 SunShot Initiative projects that are advancing solar deployment across the United States. These projects take a variety of...

  20. Assessing Pathways in Aruba

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2: Assessing Opportunity Pathways Assessing Pathways in Aruba In 2010, Prime Minister Eman of Aruba expressed an ambitious goal: to transition Aruba to 100% renew- able energy by 2020. Aruba offers a valuable example of how to approach vision and goal setting for an energy project or initiative. Challenge Strong tourism and growth in the hospitality industry are boosting economic development for the island of Aruba. However, like many islands and remote locations, Aruba must import thousands of

  1. Program Design Analysis using BEopt Building Energy Optimization Software: Defining a Technology Pathway Leading to New Homes with Zero Peak Cooling Demand; Preprint

    SciTech Connect (OSTI)

    Anderson, R.; Christensen, C.; Horowitz, S.

    2006-08-01

    An optimization method based on the evaluation of a broad range of different combinations of specific energy efficiency and renewable-energy options is used to determine the least-cost pathway to the development of new homes with zero peak cooling demand. The optimization approach conducts a sequential search of a large number of possible option combinations and uses the most cost-effective alternatives to generate a least-cost curve to achieve home-performance levels ranging from a Title 24-compliant home to a home that uses zero net source energy on an annual basis. By evaluating peak cooling load reductions on the least-cost curve, it is then possible to determine the most cost-effective combination of energy efficiency and renewable-energy options that both maximize annual energy savings and minimize peak-cooling demand.

  2. Gamma-Ray Signatures for State-Of-Health Analysis and Monitoring of Widely-Arrayed Radiation Portal Monitor Systems

    SciTech Connect (OSTI)

    Woodring, Mitchell L.; Ely, James H.; Angel, Linda K.; Wright, Ingrid H.; Eslinger, Melany A.; Pospical, A. Jill; Ellis, John E.

    2008-05-15

    Pacific Northwest National Laboratory (PNNL) has deployed a large array of radiation portal monitors for the Department of Homeland Security U.S. Customs and Border Protection. These portal monitors scan incoming vehicles crossing the U.S. border and shipping containers leaving international ports for radioactive material via gamma-ray and neutron detection. Data produced and captured by these systems are recorded for every vehicle related to radiation signature, sensor/system status, and local background, as well as a host of other variables. Within the Radiation Portal Monitor Project at PNNL, state-of-health observation and analysis for the whole RPM system using these data to determine functionality and performance is being developed. (PIET-43741-TM-492)

  3. A New Pathway for Radionuclide Uptake

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A New Pathway for Radionuclide Uptake Print Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, present severe health threats as contaminants, and understanding the scope of the biochemical interactions involved in actinide uptake into cells is instrumental in managing human contamination. Recently, scientists have reported that an iron-binding protein called siderocalin can also bind and transport actinides into cells, a major advance in understanding

  4. A New Pathway for Radionuclide Uptake

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A New Pathway for Radionuclide Uptake Print Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, present severe health threats as contaminants, and understanding the scope of the biochemical interactions involved in actinide uptake into cells is instrumental in managing human contamination. Recently, scientists have reported that an iron-binding protein called siderocalin can also bind and transport actinides into cells, a major advance in understanding

  5. A New Pathway for Radionuclide Uptake

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A New Pathway for Radionuclide Uptake Print Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, present severe health threats as contaminants, and understanding the scope of the biochemical interactions involved in actinide uptake into cells is instrumental in managing human contamination. Recently, scientists have reported that an iron-binding protein called siderocalin can also bind and transport actinides into cells, a major advance in understanding

  6. A New Pathway for Radionuclide Uptake

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A New Pathway for Radionuclide Uptake Print Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, present severe health threats as contaminants, and understanding the scope of the biochemical interactions involved in actinide uptake into cells is instrumental in managing human contamination. Recently, scientists have reported that an iron-binding protein called siderocalin can also bind and transport actinides into cells, a major advance in understanding

  7. Use of bioassays in assessing health hazards from complex mixtures: A RASH analysis

    SciTech Connect (OSTI)

    Jones, T.D.

    1993-10-14

    The Finney harmonic mean model for joint toxicity of ingredients in mixtures can be used to estimate the toxicity of the neat compound if one component can be substituted in potency-adjusted-doses for each of the other components. Chemical analysis data and relative potency values (computed according to the Rapid Screening of Hazard (RASH) method) were used to compare the toxicities as predicted from ingredients of cigarette smoke, PAHs in diesel exhaust, asphalt, coal tar, pitch, and creosote with the measured toxicities of the neat mixtures. Accuracy for cigarette smoke condensate, coal tar, pitch, and creosote were within a factor of three; asphalt within a factor of 18; but the PAC content of diesel particulate was inadequate to accurately describe the toxicity of diesel emissions.

  8. Solar Market Pathways Website

    Broader source: Energy.gov [DOE]

    The Solar Market Pathways website distributes key insights from 15 SunShot Initiative projects that are advancing solar deployment across the United States. These projects take a variety of approaches to develop actionable strategic plans to expand solar electricity use for residential, community, and commercial properties.

  9. Solar Market Pathways

    Broader source: Energy.gov [DOE]

    The Solar Market Pathways website distributes key insights from 15 SunShot Initiative projects that are advancing solar deployment across the United States. These projects take a variety of approaches to develop actionable strategic plans to expand solar electricity use for residential, community, and commercial properties.

  10. PROJECT PROFILE: Salt Lake City Corporation (Solar Market Pathways) |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Salt Lake City Corporation (Solar Market Pathways) PROJECT PROFILE: Salt Lake City Corporation (Solar Market Pathways) Title: Wasatch Solar Project WASATCH solar logo.png Funding Opportunity: Solar Market Pathways SunShot Subprogram: Soft Costs Location: Salt Lake City, UT Amount Awarded: $600,000 Awardee Cost Share: $164,645 Salt Lake City and its partners are developing a comprehensive long-term solar deployment strategy, which includes an analysis of the value of

  11. Theoretical analysis of the sequential proton-coupled electron transfer mechanisms for H2 oxidation and production pathways catalyzed by nickel molecular electrocatalysts

    SciTech Connect (OSTI)

    Fernandez, Laura; Horvath, Samantha; Hammes-Schiffer, Sharon

    2012-02-02

    The design of electrocatalysts for the oxidation and production of H2 is important for the development of alternative energy sources. This paper focuses on the electrocatalysts, where denotes 1,5-diaza-3,7-diphosphacyclooctane ligands with substituent groups R and R' covalently bound to the phosphorus and nitrogen atoms, respectively. Theoretical methods are used to investigate the mechanism of the step in the catalytic cycle corresponding to e ? for H2 oxidation and the reverse reaction for H2 production. This step involves electron transfer (ET) between the Ni complex and the electrode as well as proton transfer (PT) between the Ni and the N. The sequential mechanisms, PTET and ETPT, are investigated for the following (R,R) substituents: (Me,Me), (Ph,Ph), and (Ph,Bz), where Me, Ph, and Bz denote methyl, phenyl, and benzyl substituents. Density functional theory is used to calculate reduction potentials, pKas, and PT pathways, and Marcus theory is used to describe the electrochemical electron transfer, including the effects of solute and solvent reorganization energies. For the (Ph,Ph) and (Ph,Bz) systems, the sequential PTET mechanism would require surmounting a large free energy barrier for the initial PT step, followed by thermodynamically favorable or thermoneutral ET. The sequential ETPT mechanism for these systems would require a relatively large initial applied overpotential, followed by a PT reaction with a relatively low free energy barrier. Consistent with experimental data, the calculated overpotential required for the initial reduction in the ETPT mechanism is lower for the (Ph,Bz) system than for the (Ph,Ph) system. The concerted mechanism, in which the electron and proton transfer simultaneously without a stable intermediate, may be thermodynamically favorable and is a direction of future research. This material is based upon work supported as part of the Center for Molecular Electrocatalysis, an Energy Frontier Research Center funded by the

  12. Health effects models for nuclear power plant accident consequence analysis: Low LET radiation: Part 2, Scientific bases for health effects models

    SciTech Connect (OSTI)

    Abrahamson, S.; Bender, M.; Book, S.; Buncher, C.; Denniston, C.; Gilbert, E.; Hahn, F.; Hertzberg, V.; Maxon, H.; Scott, B.

    1989-05-01

    This report provides dose-response models intended to be used in estimating the radiological health effects of nuclear power plant accidents. Models of early and continuing effects, cancers and thyroid nodules, and genetic effects are provided. Two-parameter Weibull hazard functions are recommended for estimating the risks of early and continuing health effects. Three potentially lethal early effects -- the hematopoietic, pulmonary and gastrointestinal syndromes -- are considered. Linear and linear-quadratic models are recommended for estimating cancer risks. Parameters are given for analyzing the risks of seven types of cancer in adults -- leukemia, bone, lung, breast, gastrointestinal, thyroid and ''other''. The category, ''other'' cancers, is intended to reflect the combined risks of multiple myeloma, lymphoma, and cancers of the bladder, kidney, brain, ovary, uterus and cervix. Models of childhood cancers due to in utero exposure are also provided. For most cancers, both incidence and mortality are addressed. Linear and linear-quadratic models are also recommended for assessing genetic risks. Five classes of genetic disease -- dominant, x-linked, aneuploidy, unbalanced translocation and multifactorial diseases --are considered. In addition, the impact of radiation-induced genetic damage on the incidence of peri-implantation embryo losses is discussed. The uncertainty in modeling radiological health risks is addressed by providing central, upper, and lower estimates of all model parameters. Data are provided which should enable analysts to consider the timing and severity of each type of health risk. 22 refs., 14 figs., 51 tabs.

  13. Pathway modeling of microarray data: A case study of pathway activity changes in the testis following in utero exposure to dibutyl phthalate (DBP)

    SciTech Connect (OSTI)

    Ovacik, Meric A.; Sen, Banalata; Euling, Susan Y.; Gaido, Kevin W.; Ierapetritou, Marianthi G.; Androulakis, Ioannis P.

    2013-09-15

    Pathway activity level analysis, the approach pursued in this study, focuses on all genes that are known to be members of metabolic and signaling pathways as defined by the KEGG database. The pathway activity level analysis entails singular value decomposition (SVD) of the expression data of the genes constituting a given pathway. We explore an extension of the pathway activity methodology for application to time-course microarray data. We show that pathway analysis enhances our ability to detect biologically relevant changes in pathway activity using synthetic data. As a case study, we apply the pathway activity level formulation coupled with significance analysis to microarray data from two different rat testes exposed in utero to Dibutyl Phthalate (DBP). In utero DBP exposure in the rat results in developmental toxicity of a number of male reproductive organs, including the testes. One well-characterized mode of action for DBP and the male reproductive developmental effects is the repression of expression of genes involved in cholesterol transport, steroid biosynthesis and testosterone synthesis that lead to a decreased fetal testicular testosterone. Previous analyses of DBP testes microarray data focused on either individual gene expression changes or changes in the expression of specific genes that are hypothesized, or known, to be important in testicular development and testosterone synthesis. However, a pathway analysis may inform whether there are additional affected pathways that could inform additional modes of action linked to DBP developmental toxicity. We show that Pathway activity analysis may be considered for a more comprehensive analysis of microarray data.

  14. Pathways for Algal Biofuels

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    DEPARTMENT OF ENERGY BIOMASS PROGRAM Pathways for Algal Biofuels November 27, 2012 Daniel B. Fishman Lead Technology Development Manager 2 | Biomass Program eere.energy.gov Adds value to unproductive or marginal lands of a range of biofuel feedstocks suitable for diesel and aviation fuels Activities include R&D on algal feedstocks and issues related to the sustainable production of algae-derived biofuels. Algae Feedstocks Courtesy Sapphire Courtesy Sapphire Courtesy University of Arizona 3

  15. Career Pathways | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Career Pathways Career Pathways The Energy/National Nuclear Security Administration (NNSA) Career Pathways Program is an innovative employment program targeting students and recent college graduates. If you are seeking an entry-level federal job or a federal internship, then check out our various opportunities! Intern Program The Pathways intern program allows students taking at least a half-time course load in an accredited high school, home schooling program, technical school, vocational

  16. Improving carbon fixation pathways

    SciTech Connect (OSTI)

    Ducat, DC; Silver, PA

    2012-08-01

    A recent resurgence in basic and applied research on photosynthesis has been driven in part by recognition that fulfilling future food and energy requirements will necessitate improvements in crop carbon-fixation efficiencies. Photosynthesis in traditional terrestrial crops is being reexamined in light of molecular strategies employed by photosynthetic microbes to enhance the activity of the Calvin cycle. Synthetic biology is well-situated to provide original approaches for compartmentalizing and enhancing photosynthetic reactions in a species independent manner. Furthermore, the elucidation of alternative carbon-fixation routes distinct from the Calvin cycle raises possibilities that novel pathways and organisms can be utilized to fix atmospheric carbon dioxide into useful materials.

  17. Solar Market Pathways | Department of Energy

    Energy Savers [EERE]

    Solar Market Pathways Solar Market Pathways The Solar Market Pathways program supports 15 SunShot projects that are advancing solar deployment across the United States. These...

  18. Hydrogen Pathway Cost Distributions | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathway Cost Distributions Hydrogen Pathway Cost Distributions Presentation on hydrogen pathway cost distributions presented January 25, 2006. PDF icon wkshpstorageuihlein.pdf...

  19. Analysis of the Durability of PEM FC Membrane Electrode Assemblies in Automotive Applications through the Fundamental Understanding of Membrane and MEA Degradation Pathways

    SciTech Connect (OSTI)

    Perry, Randal L.

    2013-10-31

    The Project focused on mitigation of degradation processes on membrane electrode assemblies. The approach was to develop a model to improve understanding of the mechanisms, and to use it to focus mitigation strategies. The detailed effects of various accelerated stress tests (ASTs) were evaluated to determine the best subset to use in model development. A combination of ASTs developed by the Fuel Cell Commercialization Conference of Japan and the Fuel Cell Tech Team were selected for use. The ASTs were compared by measuring effects on performance, running in-situ diagnostics, and performing microscopic analyses of the membrane electrode assemblies after the stress tests were complete. Nissan ran FCCJ AST protocols and performed in situ and ex-situ electrochemical testing. DuPont ran FCTT and USFCC AST protocols, performed scanning and transmission electron microscopy and ran in-situ electrochemical tests. Other ex-situ testing was performed by IIT, along with much of the data analysis and model development. These tests were then modified to generate time-dependent data of the degradation mechanisms. Three different catalyst types and four membrane variants were then used to generate data for a theoretically-based degradation model. An important part of the approach was to use commercially available materials in the electrodes and membranes made in scalable semiworks processes rather than lab-based materials. This constraint ensured all materials would be practicable for full-scale testing. The initial model for the electrode layer was tested for internal consistency and agreement with the data. A Java-based computer application was developed to analyze the time-dependent AST data using polarization curves with four different cathode gas feeds and generate model parameters. Data showed very good reproducibility and good consistency as cathode catalyst loadings were varied. At the point of termination of the project, a basic electrode model was in hand with several

  20. Leakage pathway layer for solar cell

    SciTech Connect (OSTI)

    Luan, Andy; Smith, David; Cousins, Peter; Sun, Sheng

    2015-12-01

    Leakage pathway layers for solar cells and methods of forming leakage pathway layers for solar cells are described.

  1. ORISE: Health Physics Training

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health Physics Training Student performs an analysis during an ORAU health physics training course Training and educating a highly skilled workforce that can meet operational commitments in the areas of radiation and health physics is an essential part of protecting your workers, the public and the environment. ORAU, the managing contractor of the Oak Ridge Institute for Science and Education, offers hands-on, laboratory-based training courses in a variety of health physics areas. Training

  2. Implementing 10 CFR 830 at the FEMP Silos: Nuclear Health and Safety Plans as Documented Safety Analysis

    SciTech Connect (OSTI)

    Fisk, Patricia; Rutherford, Lavon

    2003-06-01

    The objective of the Silos Project at the Fernald Closure Project (FCP) is to safely remediate high-grade uranium ore residues (Silos 1 and 2) and metal oxide residues (Silo 3). The evolution of Documented Safety Analyses (DSAs) for these facilities has reflected the changes in remediation processes. The final stage in silos DSAs is an interpretation of 10 CFR 830 Safe Harbor Requirements that combines a Health and Safety Plan with nuclear safety requirements. This paper will address the development of a Nuclear Health and Safety Plan, or N-HASP.

  3. Health & Safety

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health & Safety Health & Safety1354608000000Health & SafetySome of these resources are LANL-only and will require Remote Access.NoQuestions? 667-5809library@lanl.gov Health &...

  4. Protein design for pathway engineering

    SciTech Connect (OSTI)

    Eriksen, DT; Lian, JZ; Zhao, HM

    2014-02-01

    Design and construction of biochemical pathways has increased the complexity of biosynthetically-produced compounds when compared to single enzyme biocatalysis. However, the coordination of multiple enzymes can introduce a complicated set of obstacles to overcome in order to achieve a high titer and yield of the desired compound. Metabolic engineering has made great strides in developing tools to optimize the flux through a target pathway, but the inherent characteristics of a particular enzyme within the pathway can still limit the productivity. Thus, judicious protein design is critical for metabolic and pathway engineering. This review will describe various strategies and examples of applying protein design to pathway engineering to optimize the flux through the pathway. The proteins can be engineered for altered substrate specificity/selectivity, increased catalytic activity, reduced mass transfer limitations through specific protein localization, and reduced substrate/product inhibition. Protein engineering can also be expanded to design biosensors to enable high through-put screening and to customize cell signaling networks. These strategies have successfully engineered pathways for significantly increased productivity of the desired product or in the production of novel compounds. (C) 2013 Elsevier Inc. All rights reserved.

  5. China 2050 Pathways Calculator | Open Energy Information

    Open Energy Info (EERE)

    2050 Pathways Calculator Jump to: navigation, search Tool Summary LAUNCH TOOL Name: China 2050 Pathways Calculator AgencyCompany Organization: China's Energy Research Institute...

  6. PROJECT PROFILE: Extensible Energy (Solar Market Pathways) |...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Extensible Energy (Solar Market Pathways) PROJECT PROFILE: Extensible Energy (Solar Market Pathways) Title: High-Value Integrated Community Solar Project Extensible Energy logo.jpg ...

  7. The development and application of the chemical mixture methodology in analysis of potential health impacts from airborne release in emergencies

    SciTech Connect (OSTI)

    Yu, Xiao-Ying; Petrocchi, Achille J.; Craig, Douglas K.; Glantz, Clifford S.; Trott, Donna M.; Ciolek, John T.; Lu, Po-Yung; Bond, Jayne-Anne; Tuccinardi, Thomas E.; Bouslaugh, Philip R.

    2010-07-15

    The Chemical Mixture Methodology (CMM) is used for emergency response and safety planning by the U.S. Department of Energy, its contractors, and other private and public sector organizations. The CMM estimates potential health impacts on individuals and their ability to take protective actions as a result of exposure to airborne chemical mixtures. They are based on the concentration of each chemical in the mixture at a designated receptor location, the protective action criteria (PAC) providing chemical-specific exposure limit values, and the health code numbers (HCNs) that identify the target organ groupings that may be impacted by exposure to each chemical in a mixture. The CMM has been significantly improved since its introduction more than 10 years ago. Major enhancements involve the expansion of the number of HCNs from 44 to 60 and inclusion of updated PAC values based on an improved development methodology and updates in the data used to derive the PAC values. Comparisons between the 1999 and 2009 versions of the CMM show potentially substantial changes in the assessment results for selected sets of chemical mixtures. In particular, the toxic mode hazard indices (HIs) and target organ HIs are based on more refined acute HCNs, thereby improving the quality of chemical consequence assessment, emergency planning, and emergency response decision making. Seven hypothetical chemical storage and processing scenarios are used to demonstrate how the CMM is applied in emergency planning and hazard assessment.

  8. Health Physicist

    Broader source: Energy.gov [DOE]

    This position is located in the Office of Environment, Health, Safety and Security (EHSS) which manages the Department of Energy's (DOE) major staff organizations responsible for health, safety,...

  9. Health Videos

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Health Videos Health Videos Our videos speak more than a thousand words about our science and technology, community outreach, collaborations, careers, and much more. News Releases...

  10. Kaiser Permanente-Sandia National Health Care Model: Phase 1 prototype final report. Part 2 -- Domain analysis

    SciTech Connect (OSTI)

    Edwards, D.; Yoshimura, A.; Butler, D.; Judson, R.; Mason, W.; Napolitano, L.; Mariano, R.; Eddy, D.; Schlessinger, L.

    1996-11-01

    This report describes the results of a Cooperative Research and Development Agreement between Sandia National Laboratories and Kaiser Permanente Southern California to develop a prototype computer model of Kaiser Permanente`s health care delivery system. As a discrete event simulation, SimHCO models for each of 100,000 patients the progression of disease, individual resource usage, and patient choices in a competitive environment. SimHCO is implemented in the object-oriented programming language C{sup 2}, stressing reusable knowledge and reusable software components. The versioned implementation of SimHCO showed that the object-oriented framework allows the program to grow in complexity in an incremental way. Furthermore, timing calculations showed that SimHCO runs in a reasonable time on typical workstations, and that a second phase model will scale proportionally and run within the system constraints of contemporary computer technology.

  11. Transportation Energy Pathways LDRD.

    SciTech Connect (OSTI)

    Barter, Garrett; Reichmuth, David; Westbrook, Jessica; Malczynski, Leonard A.; Yoshimura, Ann S.; Peterson, Meghan; West, Todd H.; Manley, Dawn Kataoka; Guzman, Katherine Dunphy; Edwards, Donna M.; Hines, Valerie Ann-Peters

    2012-09-01

    This report presents a system dynamics based model of the supply-demand interactions between the USlight-duty vehicle (LDV) fleet, its fuels, and the corresponding primary energy sources through the year2050. An important capability of our model is the ability to conduct parametric analyses. Others have reliedupon scenario-based analysis, where one discrete set of values is assigned to the input variables and used togenerate one possible realization of the future. While these scenarios can be illustrative of dominant trendsand tradeoffs under certain circumstances, changes in input values or assumptions can have a significantimpact on results, especially when output metrics are associated with projections far into the future. Thistype of uncertainty can be addressed by using a parametric study to examine a range of values for the inputvariables, offering a richer source of data to an analyst.The parametric analysis featured here focuses on a trade space exploration, with emphasis on factors thatinfluence the adoption rates of electric vehicles (EVs), the reduction of GHG emissions, and the reduction ofpetroleum consumption within the US LDV fleet. The underlying model emphasizes competition between13 different types of powertrains, including conventional internal combustion engine (ICE) vehicles, flex-fuel vehicles (FFVs), conventional hybrids(HEVs), plug-in hybrids (PHEVs), and battery electric vehicles(BEVs).We find that many factors contribute to the adoption rates of EVs. These include the pace of technologicaldevelopment for the electric powertrain, battery performance, as well as the efficiency improvements inconventional vehicles. Policy initiatives can also have a dramatic impact on the degree of EV adoption. Theconsumer effective payback period, in particular, can significantly increase the market penetration rates ifextended towards the vehicle lifetime.Widespread EV adoption can have noticeable impact on petroleum consumption and greenhouse gas

  12. Molecular pathways of angiogenesis inhibition

    SciTech Connect (OSTI)

    Tabruyn, Sebastien P.; Griffioen, Arjan W. . E-mail: aw.griffioen@path.unimaas.nl

    2007-03-30

    A large body of evidence now demonstrates that angiostatic therapy represents a promising way to fight cancer. This research recently resulted in the approval of First angiostatic agent for clinical treatment of cancer. Progress has been achieved in decrypting the cellular signaling in endothelial cells induced by angiostatic agents. These agents predominantly interfere with the molecular pathways involved in migration, proliferation and endothelial cell survival. In the current review, these pathways are discussed. A thorough understanding of the mechanism of action of angiostatic agents is required to develop efficient anti-tumor therapies.

  13. Rapid prototype extruded conductive pathways

    DOE Patents [OSTI]

    Bobbitt, III, John T.

    2016-06-21

    A process of producing electrically conductive pathways within additively manufactured parts and similar parts made by plastic extrusion nozzles. The process allows for a three-dimensional part having both conductive and non-conductive portions and allows for such parts to be manufactured in a single production step.

  14. Pathways for Algal Biofuels | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathways for Algal Biofuels Pathways for Algal Biofuels This is a presentation from the November 27, 2012, Sustainable Alternative Fuels Cost Workshop given by Daniel B. Fishman, of the Biomass Program. fishman_caafi_workshop.pdf (1.3 MB) More Documents & Publications Bioenergy Technologies Office Conversion R&D Pathway: Whole Algae Hydrothermal Liquefaction Technology Pathway Selection Effort Whole Algae Hydrothermal Liquefaction

  15. The role of technology in reducing health care costs. Final project report

    SciTech Connect (OSTI)

    Sill, A.E.; Warren, S.; Dillinger, J.D.; Cloer, B.K.

    1997-08-01

    Sandia National Laboratories applied a systems approach to identifying innovative biomedical technologies with the potential to reduce U.S. health care delivery costs while maintaining care quality. This study was conducted by implementing both top-down and bottom-up strategies. The top-down approach used prosperity gaming methodology to identify future health care delivery needs. This effort provided roadmaps for the development and integration of technology to meet perceived care delivery requirements. The bottom-up approach identified and ranked interventional therapies employed in existing care delivery systems for a host of health-related conditions. Economic analysis formed the basis for development of care pathway interaction models for two of the most pervasive, chronic disease/disability conditions: coronary artery disease (CAD) and benign prostatic hypertrophy (BPH). Societal cost-benefit relationships based on these analyses were used to evaluate the effect of emerging technology in these treatment areas. 17 figs., 48 tabs.

  16. Enhancing Automatic Biological Pathway Generation with GO-based Gene Similarity

    SciTech Connect (OSTI)

    Sanfilippo, Antonio P.; Baddeley, Robert L.; Beagley, Nathaniel; Riensche, Roderick M.; Gopalan, Banu

    2009-08-03

    One of the greatest challenges in today’s analysis of microarray gene expression data is to identify pathways across regulated genes that underlie structural and functional changes of living cells in specific pathologies. Most current approaches to pathway generation are based on a reverse engineering approach in which pathway plausibility is solely induced from observed pathway data. These approaches tend to lack in generality as they are too dependent on the pathway observables from which they are induced. By contrast, alternative approaches that rely on prior biological knowledge may err in the opposite direction as the prior knowledge is usually not sufficiently tuned to the pathology of focus. In this paper, we present a novel pathway generation approach which combines insights from the reverse engineering and knowledge-based approaches to increase the biological plausibility and specificity of induced regulatory networks.

  17. ERβ induces the differentiation of cultured osteoblasts by both Wnt/β-catenin signaling pathway and estrogen signaling pathways

    SciTech Connect (OSTI)

    Yin, Xinhua; Wang, Xiaoyuan; Hu, Xiongke; Chen, Yong; Zeng, Kefeng; Zhang, Hongqi

    2015-07-01

    Although 17β-estradial (E2) is known to stimulate bone formation, the underlying mechanisms are not fully understood. Recent studies have implicated the Wnt/β-catenin pathway as a major signaling cascade in bone biology. The interactions between Wnt/β-catenin signaling pathway and estrogen signaling pathways have been reported in many tissues. In this study, E2 significantly increased the expression of β-catenin by inducing phosphorylations of GSK3β at serine 9. ERβ siRNAs were transfected into MC3T3-E1 cells and revealed that ERβ involved E2-induced osteoblasts proliferation and differentiation via Wnt/β-catenin signaling. The osteoblast differentiation genes (BGP, ALP and OPN) and proliferation related gene (cyclin D1) expression were significantly induced by E2-mediated ERβ. Furthermore immunofluorescence and immunoprecipitation analysis demonstrated that E2 induced the accumulation of β-catenin protein in the nucleus which leads to interaction with T-cell-specific transcription factor/lymphoid enhancer binding factor (TCF/LEF) transcription factors. Taken together, these findings suggest that E2 promotes osteoblastic proliferation and differentiation by inducing proliferation-related and differentiation-related gene expression via ERβ/GSK-3β-dependent Wnt/β-catenin signaling pathway. Our findings provide novel insights into the mechanisms of action of E2 in osteoblastogenesis. - Highlights: • 17β-estradial (E2) promotes GSK3-β phosphorylation. • E2 activates the Wnt/β-catenin signaling pathway. • The Wnt/β-catenin signaling pathway interacts with estrogen signaling pathways. • E2-mediated ER induced osteoblast differentiation and proliferation related genes expression.

  18. PROJECT PROFILE: Dominion Virginia Power (Solar Market Pathways...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Dominion Virginia Power (Solar Market Pathways) PROJECT PROFILE: Dominion Virginia Power (Solar Market Pathways) Title: Virginia Solar Pathways Project Dominion logo.png Funding ...

  19. US DRIVE Fuel Pathway Integration Technical Team Roadmap | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fuel Pathway Integration Technical Team Roadmap US DRIVE Fuel Pathway Integration Technical Team Roadmap The Fuel Pathway Integration Technical Team (FPITT) supports the U.S. DRIVE ...

  20. Iron deficiency is associated with increased levels of blood cadmium in the Korean general population: Analysis of 2008-2009 Korean National Health and Nutrition Examination Survey data

    SciTech Connect (OSTI)

    Lee, Byung-Kook; Kim, Yangho

    2012-01-15

    Introduction: We present data from the Korean National Health and Nutrition Examination Survey 2008-2009 on the distribution of blood cadmium levels and their association with iron deficiency in a representative sample of the adult Korean population. Methods: Serum ferritin was categorized into three levels: low (serum ferritin <15.0 {mu}g/L), low normal (15.0-30.0 {mu}g/L for women and 15.0-50.0 for men), and normal ({>=}30.0 {mu}g/L for women and {>=}50.0 for men), and its association with blood cadmium level was assessed after adjustment for various demographic and lifestyle factors. Results: Geometric means of blood cadmium in the low serum ferritin group in women, men, and all participants were significantly higher than in the normal group. Additionally, multiple regression analysis after adjusting for various covariates showed that blood cadmium was significantly higher in the low-ferritin group in women, men, and all participants compared with the normal group. We also found an association between serum ferritin and blood cadmium among never-smoking participants. Discussion: We found, similar to other recent population-based studies, an association between iron deficiency and increased blood cadmium in men and women, independent of smoking status. The results of the present study show that iron deficiency is associated with increased levels of blood cadmium in the general population.

  1. Combustion kinetics and reaction pathways

    SciTech Connect (OSTI)

    Klemm, R.B.; Sutherland, J.W.

    1993-12-01

    This project is focused on the fundamental chemistry of combustion. The overall objectives are to determine rate constants for elementary reactions and to elucidate the pathways of multichannel reactions. A multitechnique approach that features three independent experiments provides unique capabilities in performing reliable kinetic measurements over an exceptionally wide range in temperature, 300 to 2500 K. Recent kinetic work has focused on experimental studies and theoretical calculations of the methane dissociation system (CH{sub 4} + Ar {yields} CH{sub 3} + H + Ar and H + CH{sub 4} {yields} CH{sub 3} + H{sub 2}). Additionally, a discharge flow-photoionization mass spectrometer (DF-PIMS) experiment is used to determine branching fractions for multichannel reactions and to measure ionization thresholds of free radicals. Thus, these photoionization experiments generate data that are relevant to both reaction pathways studies (reaction dynamics) and fundamental thermochemical research. Two distinct advantages of performing PIMS with high intensity, tunable vacuum ultraviolet light at the National Synchrotron Light Source are high detection sensitivity and exceptional selectivity in monitoring radical species.

  2. Employee Agreement for Pathways Program | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Agreement for Pathways Program Employee Agreement for Pathways Program Employee Agreement for Pathways Program (331.12 KB) More Documents & Publications Career Pathways Frequently Asked Questions (FAQs) DOE Mentoring Guidance and Program Plan Book1

  3. Thermochemical Conversion Techno-Economic Analysis | Bioenergy...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ... Indirect Liquefaction Pathway Analysis Gasification, indirect liquefaction or gaseous ... Current areas of research and analysis at NREL focus on catalyst development, increasing ...

  4. H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report H2A Hydrogen Delivery Infrastructure Analysis Models and ...

  5. Fuel Dependence of Benzene Pathways

    SciTech Connect (OSTI)

    Zhang, H; Eddings, E; Sarofim, A; Westbrook, C

    2008-07-14

    The relative importance of formation pathways for benzene, an important precursor to soot formation, was determined from the simulation of 22 premixed flames for a wide range of equivalence ratios (1.0 to 3.06), fuels (C{sub 1}-C{sub 12}), and pressures (20 to 760 torr). The maximum benzene concentrations in 15 out of these flames were well reproduced within 30% of the experimental data. Fuel structural properties were found to be critical for benzene production. Cyclohexanes and C{sub 3} and C{sub 4} fuels were found to be among the most productive in benzene formation; and long-chain normal paraffins produce the least amount of benzene. Other properties, such as equivalence ratio and combustion temperatures, were also found to be important in determining the amount of benzene produced in flames. Reaction pathways for benzene formation were examined critically in four premixed flames of structurally different fuels of acetylene, n-decane, butadiene, and cyclohexane. Reactions involving precursors, such as C{sub 3} and C{sub 4} species, were examined. Combination reactions of C{sub 3} species were identified to be the major benzene formation routes with the exception of the cyclohexane flame, in which benzene is formed exclusively from cascading fuel dehydrogenation via cyclohexene and cyclohexadiene intermediates. Acetylene addition makes a minor contribution to benzene formation, except in the butadiene flame where C{sub 4}H{sub 5} radicals are produced directly from the fuel, and in the n-decane flame where C{sub 4}H{sub 5} radicals are produced from large alkyl radical decomposition and H atom abstraction from the resulting large olefins.

  6. Charting a Path Forward:New Pathways to Hydrocarbon Biofuels

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    road mapping workshop on Conversion Technologies for Advanced Biofuels (CTAB) Workshop brought together representatives from national labs, industry and academia to identify critical areas of focus * In March 2012, initiated effort to identify new pathways to hydrocarbon fuels and intermediates - Leveraged existing models and ongoing analysis at NREL, PNNL and NABC 3 | Bioenergy Technologies Office Purpose * Setting R&D priorities * Guiding program direction * Identifying technology process

  7. Hydrogen Production Pathways | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathways Hydrogen Production Pathways Hydrogen Production Pathways DOE is focused on developing technologies that can produce hydrogen at a target of less than $4/kg (delivered and dispensed). To reach these goals, the program looks at a wide portfolio of processes over a range of time frames and production scales. Currently, most hydrogen in the United States is produced by large-scale natural gas reforming. This established technology has been shown to be able to reach the cost targets in the

  8. Solar Market Pathways | Department of Energy

    Energy Savers [EERE]

    The Solar Market Pathways program supports 15 SunShot ... property assessed clean energy, and the integration of ... 15 of its member colleges and their hometown communities. ...

  9. Titanium ? - ? phase transformation pathway and a predicted...

    Office of Scientific and Technical Information (OSTI)

    Titanium - phase transformation pathway and a predicted metastable structure Citation Details In-Document Search This content will become publicly available on January 14,...

  10. NREL: Energy Analysis - Mackay Miller

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and multilateral initiatives including the US-China Renewable Energy Partnership and 21st Century Power Partnership Quantitative social network analysis of innovation pathways...

  11. Emergency Response Health Physics

    SciTech Connect (OSTI)

    Mena, R., Pemberton, W., Beal, W.

    2012-05-01

    Health physics is an important discipline with regard to understanding the effects of radiation on human health. Topics of discussion included in this manuscript are related to responding to a radiation emergency, and the necessary balance between desired high accuracy laboratory results and rapid turnaround requirements. Considerations are addressed for methodology with which to provide the most competent solutions despite challenges presented from incomplete datasets and, at times, limited methodology. An emphasis is placed on error and uncertainty of sample analysis results, how error affects products, and what is communicated in the final product.

  12. Technology Pathway Selection Effort | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Technology Pathway Selection Effort Technology Pathway Selection Effort This is a presentation from the November 27, 2012, Sustainable Alternative Fuels Cost Workshop given by Alicia Lindauer. lindauer_caafi_workshop.pdf (525.95 KB) More Documents & Publications Conversion Technologies for Advanced Biofuels - Bio-Oil Production 2013 Peer Review Presnentations-Plenaries Thermochemical Conversion Proceeses to Aviation Fuels

  13. Fuel Pathway Integration Technical Team Roadmap

    SciTech Connect (OSTI)

    2013-06-01

    The Fuel Pathway Integration Technical Team (FPITT) supports the U.S. DRIVE Partnership (the Partnership) in the identification and evaluation of implementation scenarios for fuel cell technology pathways, including hydrogen and fuel cell electric vehicles in the transportation sector, both during a transition period and in the long term.

  14. Bottom-Up Energy Analysis System (BUENAS) | Open Energy Information

    Open Energy Info (EERE)

    Lawrence Berkeley National Laboratory Sector: Energy Focus Area: Buildings, Energy Efficiency Topics: Baseline projection, - Macroeconomic, Pathways analysis Resource Type:...

  15. ORISE: Statistical Analyses of Worker Health

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    appropriate methods of statistical analysis to a variety of problems in occupational health and other areas. Our expertise spans a range of capabilities essential for statistical...

  16. Analysis of environment, safety, and health (ES{ampersand}H) management systems for Department of Energy (DOE) Defense Programs (DP) facilities

    SciTech Connect (OSTI)

    Neglia, A. V., LLNL

    1998-03-01

    The purpose of this paper is to provide a summary analysis and comparison of various environment, safety, and health (ES&H) management systems required of, or suggested for use by, the Departrnent of Energy Defense Programs` sites. The summary analysis is provided by means of a comparison matrix, a set of Vean diagrams that highlights the focus of the systems, and an `End Gate` filter diagram that integrates the three Vean diagrams. It is intended that this paper will act as a starting point for implementing a particular system or in establishing a comprehensive site-wide integrated ES&H management system. Obviously, the source documents for each system would need to be reviewed to assure proper implementation of a particular system. The matrix compares nine ES&H management systems against a list of elements generated by identifying the unique elements of all the systems. To simplify the matrix, the elements are listed by means of a brief title. An explanation of the matrix elements is provided in Attachment 2 entitled, `Description of System Elements.` The elements are categorized under the Total Quality Management (TQM) `Plan, Do, Check, Act` framework with the added category of `Policy`. (The TQM concept is explained in the `DOE Quality Management implementation Guidelines,` July 1997 (DOE/QM- 0008)). The matrix provides a series of columns and rows to compare the unique elements found in each of the management systems. A `V` is marked if the element is explicitly identified as part of the particular ES&H management system. An `X` is marked if the element is not found in the particular ES&H management system, or if it is considered to be inadequately addressed. A `?` is marked if incorporation of the element is not clear. Attachment I provides additional background information which explains the justification for the marks in the matrix cells. Through the Vean diagrams and the `End Gate` filter in Section 3, the paper attempts to pictorially display the focus of

  17. Syngas Upgrading to Hydrocarbon Fuels Technology Pathway

    SciTech Connect (OSTI)

    Talmadge, M.; Biddy, M.; Dutta, A.; Jones, S.; Meyer, A.

    2013-03-01

    This technology pathway case investigates the upgrading of woody biomass derived synthesis gas (syngas) to hydrocarbon biofuels. While this specific discussion focuses on the conversion of syngas via a methanol intermediate to hydrocarbon blendstocks, there are a number of alternative conversion routes for production of hydrocarbons through a wide array of intermediates from syngas. Future work will also consider the variations to this pathway to determine the most economically viable and lowest risk conversion route. Technical barriers and key research needs have been identified that should be pursued for the syngas-to-hydrocarbon pathway to be competitive with petroleum-derived gasoline-, diesel- and jet-range hydrocarbon blendstocks.

  18. Including the temporal change in PM{sub 2.5} concentration in the assessment of human health impact: Illustration with renewable energy scenarios to 2050

    SciTech Connect (OSTI)

    Gschwind, Benoit; Lefevre, Mireille; Blanc, Isabelle; Ranchin, Thierry; Wyrwa, Artur; Drebszok, Kamila; Cofala, Janusz; Fuss, Sabine

    2015-04-15

    This article proposes a new method to assess the health impact of populations exposed to fine particles (PM{sub 2.5}) during their whole lifetime, which is suitable for comparative analysis of energy scenarios. The method takes into account the variation of particle concentrations over time as well as the evolution of population cohorts. Its capabilities are demonstrated for two pathways of European energy system development up to 2050: the Baseline (BL) and the Low Carbon, Maximum Renewable Power (LC-MRP). These pathways were combined with three sets of assumptions about emission control measures: Current Legislation (CLE), Fixed Emission Factors (FEFs), and the Maximum Technically Feasible Reductions (MTFRs). Analysis was carried out for 45 European countries. Average PM{sub 2.5} concentration over Europe in the LC-MRP/CLE scenario is reduced by 58% compared with the BL/FEF case. Health impacts (expressed in days of loss of life expectancy) decrease by 21%. For the LC-MRP/MTFR scenario the average PM{sub 2.5} concentration is reduced by 85% and the health impact by 34%. The methodology was developed within the framework of the EU's FP7 EnerGEO project and was implemented in the Platform of Integrated Assessment (PIA). The Platform enables performing health impact assessments for various energy scenarios. - Highlights: • A new method to assess health impact of PM{sub 2.5} for energy scenarios is proposed. • An algorithm to compute Loss of Life Expectancy attributable to exposure to PM{sub 2.5} is depicted. • Its capabilities are demonstrated for two pathways of European energy system development up to 2050. • Integrating the temporal evolution of PM{sub 2.5} is of great interest for assessing the potential impacts of energy scenarios.

  19. Light Duty Vehicle Pathways | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Vehicle Pathways Light Duty Vehicle Pathways Presented at the U.S. Department of Energy Light Duty Vehicle Workshop in Washington, D.C. on July 26, 2010. lightduty_vehicle_studies.pdf (561.55 KB) More Documents & Publications Presentation to EAC: Renewable Electricity Futures Activities & Status, October 29, 2010 CAAFI Progress Update Alternative Transportation Technologies: Hydrogen, Biofuels, Advanced Efficiency, and Plug-in Hybrid Electric Vehicles

  20. Pathways to Energy Development and Energy Security

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathways to Energy Development & Energy Security March 24, 2013 Lizana Pierce, Project Manager Pathway to Project Development Strategic Energy Planning * Creating a roadmap Feasibility Study * Possible roads to the future Organizational Development * Vehicles of change Project Development * Where the rubber meets the road Strategic Energy Planning Begins with an Energy Vision " The Energy Vision of the Penobscot Nation is to maximize the efficiency of energy usage and develop energy

  1. Pathways to Energy Developmenty & Energy Security

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    U.S. DEPARTMENT OF ENERGY OFFICE OF ENERGY EFFICIENCY AND RENEWABLE ENERGY DOE's Tribal Energy Program Pathways to Energy Development & Energy Security November 13, 2012 Lizana Pierce, Project Manager U.S. DOE, Tribal Energy Program Pathway to Project Development Strategic Energy Planning * CreaDng a roadmap Feasibility Study * Possible roads to the future OrganizaDonal Development * Vehicles of change Project Development * Where the rubber meets the road Strategic Energy Planning Begins

  2. H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathway Options Analysis Results - Interim Report | Department of Energy Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report H2A Hydrogen Delivery Infrastructure Analysis Models and Conventional Pathway Options Analysis Results - Interim Report An in-depth comparative analysis of promising infrastructure options for hydrogen delivery and distribution to refueling stations from central, semi-central, and distributed production facilities.

  3. Health effects of risk-assessment categories

    SciTech Connect (OSTI)

    Kramer, C.F.; Rybicka, K.; Knutson, A.; Morris, S.C.

    1983-10-01

    Environmental and occupational health effects associated with exposures to various chemicals are a subject of increasing concern. One recently developed methodology for assessing the health impacts of various chemical compounds involves the classification of similar chemicals into risk-assessment categories (RACs). This report reviews documented human health effects for a broad range of pollutants, classified by RACs. It complements other studies that have estimated human health effects by RAC based on analysis and extrapolation of data from animal research.

  4. Syngas Upgrading to Hydrocarbon Fuels Technology Pathway | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathway This technology pathway case investigates the upgrading of woody biomass derived synthesis gas (syngas) to hydrocarbon biofuels. While this specific discussion...

  5. In-Situ Catalytic Fast Pyrolysis Technology Pathway | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    needs that should be pursued for this pathway to be competitive with petroleum-derived blendstocks have been identified. In-Situ Catalytic Fast Pyrolysis Technology Pathway...

  6. Fuel Cell and Hydrogen Pathways to Clean Cities: A Stakeholder...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Fuel Cell and Hydrogen Pathways to Clean Cities: A Stakeholder - Government Engagement Fuel Cell and Hydrogen Pathways to Clean Cities: A Stakeholder - Government Engagement May ...

  7. Bioenergy Technologies Office R&D Pathways: Fast Pyrolysis and...

    Broader source: Energy.gov (indexed) [DOE]

    Bioenergy Technologies Office R&D Pathways: Fast Pyrolysis and Hydroprocessing (471.51 KB) More Documents & Publications Bioenergy Technologies Office R&D Pathways: In-Situ ...

  8. The Pathway to Energy Security | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathway to Energy Security The Pathway to Energy Security Diesel Engine Emissions Reduction (DEER) 2004 Conference Presentation: U.S. Department of Energy, FreedomCAR and Vehicle ...

  9. Rotary Vapor Compression Cycle Technology: A Pathway to Ultra...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Rotary Vapor Compression Cycle Technology: A Pathway to Ultra-Efficient Air Conditioning, Heating and Refrigeration Rotary Vapor Compression Cycle Technology: A Pathway to...

  10. DOE Materials-Based Hydrogen Storage Summit: Defining Pathways...

    Office of Environmental Management (EM)

    Materials-Based Hydrogen Storage Summit: Defining Pathways for Onboard Automotive Applications DOE Materials-Based Hydrogen Storage Summit: Defining Pathways for Onboard Automotive ...

  11. 2010 Pathways to Commercial Success: Technologies and Products...

    Office of Environmental Management (EM)

    0 Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program 2010 Pathways to Commercial Success: Technologies and Products Supported ...

  12. Molecular details of a starch utilization pathway in the human...

    Office of Scientific and Technical Information (OSTI)

    pathway in the human gut symbiont Eubacterium rectale Citation Details In-Document Search Title: Molecular details of a starch utilization pathway in the human gut symbiont ...

  13. 2011 Pathways to Commercial Success: Technologies and Products...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    1 Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program 2011 Pathways to Commercial Success: Technologies and Products Supported ...

  14. 2013 Pathways to Commercial Success: Technologies and Products...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    3 Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office 2013 Pathways to Commercial Success: Technologies and Products Supported ...

  15. 2014 Pathways to Commercial Success: Technologies and Products...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    4 Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Office 2014 Pathways to Commercial Success: Technologies and Products Supported ...

  16. 2012 Pathways to Commercial Success: Technologies and Products...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    2012 Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell Technologies Program 2012 Pathways to Commercial Success: Technologies and Products ...

  17. Ad Lucem: Modeling of Market Transformation Pathways Workshop...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Ad Lucem: Modeling of Market Transformation Pathways Workshop Agenda This document details the agenda for the DOE Ad Lucem: Modeling of Market Transformation Pathways Workshop on ...

  18. New Cyanobacteria Metabolic Pathway Critical to Energy Conversion

    SciTech Connect (OSTI)

    2015-12-01

    A little-known metabolic pathway in photosynthetic organisms is actually a major pathway for converting carbon dioxide to biofuels and bioproducts.

  19. Natural Gas Pathways and Fuel Economy Guide Comparison

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    I presentation slides: Natural Gas pathways and Fuel economy Guide Comparison Bob Wimmer, Toyota Natural Gas Pathways Toyota estimation Vehicle Total Fuel efficiency Range ...

  20. Quantum control and pathway manipulation in rubidium (Journal...

    Office of Scientific and Technical Information (OSTI)

    Quantum control and pathway manipulation in rubidium This content will become publicly available on September 28, 2016 Prev Next Title: Quantum control and pathway ...

  1. Simplified Protein Models: Predicting Folding Pathways and Structure...

    Office of Scientific and Technical Information (OSTI)

    Simplified Protein Models: Predicting Folding Pathways and Structure Using Amino Acid Sequences Title: Simplified Protein Models: Predicting Folding Pathways and Structure Using ...

  2. Biofuels Fuels Technology Pathway Options for Advanced Drop-in Biofuels Production

    SciTech Connect (OSTI)

    Kevin L Kenney

    2011-09-01

    Advanced drop-in hydrocarbon biofuels require biofuel alternatives for refinery products other than gasoline. Candidate biofuels must have performance characteristics equivalent to conventional petroleum-based fuels. The technology pathways for biofuel alternatives also must be plausible, sustainable (e.g., positive energy balance, environmentally benign, etc.), and demonstrate a reasonable pathway to economic viability and end-user affordability. Viable biofuels technology pathways must address feedstock production and environmental issues through to the fuel or chemical end products. Potential end products include compatible replacement fuel products (e.g., gasoline, diesel, and JP8 and JP5 jet fuel) and other petroleum products or chemicals typically produced from a barrel of crude. Considering the complexity and technology diversity of a complete biofuels supply chain, no single entity or technology provider is capable of addressing in depth all aspects of any given pathway; however, all the necessary expert entities exist. As such, we propose the assembly of a team capable of conducting an in-depth technology pathway options analysis (including sustainability indicators and complete LCA) to identify and define the domestic biofuel pathways for a Green Fleet. This team is not only capable of conducting in-depth analyses on technology pathways, but collectively they are able to trouble shoot and/or engineer solutions that would give industrial technology providers the highest potential for success. Such a team would provide the greatest possible down-side protection for high-risk advanced drop-in biofuels procurement(s).

  3. EPA-Integrated Environmental Strategies | Open Energy Information

    Open Energy Info (EERE)

    Background analysis, Co-benefits assessment, - Environmental and Biodiversity, - Health, - Macroeconomic, Implementation, Pathways analysis, Policiesdeployment programs...

  4. Structural Health Monitoring

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Structural Health Monitoring Engineering Institute Structural Health Monitoring Structural Health Monitoring is the process of implementing a damage detection strategy for...

  5. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production

    Fuel Cell Technologies Publication and Product Library (EERE)

    Report documenting the biological and engineering characteristics of five algal and bacterial hydrogen production systems selected by DOE and NREL for evaluation.

  6. Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production

    SciTech Connect (OSTI)

    James, B. D.; Baum, G. N.; Perez, J.; Baum, K. N.

    2009-09-01

    Report documenting the biological and engineering characteristics of five algal and bacterial hydrogen production systems selected by DOE and NREL for evaluation.

  7. Analysis of Metabolic Pathways and Fluxes in a Newly Discovered...

    Office of Scientific and Technical Information (OSTI)

    a maximum ethanol yield of 0.38+-0.07 mol mol-1 more glucose. In silico flux balance modeling demonstrates that lactate and acetate production from G. thermoglucosidasius...

  8. Analysis of Metabolic Pathways and Fluxes in a Newly Discovered...

    Office of Scientific and Technical Information (OSTI)

    provided as a public service. Visit OSTI to utilize additional information resources in energy science and technology. A paper copy of this document is also available for sale to...

  9. Deduction and Analysis of the Interacting Stress Response Pathways...

    Office of Scientific and Technical Information (OSTI)

    gene function, regulation, network and evolution of Desulfovibrio vugaris Hildenborough ... gene function, regulation, network, and evolution in D. vulgaris, and microbial community ...

  10. Poster Thur Eve 51: An analysis of the effectiveness of automated pre-, post- and intra-treatment auditing of electronic health records

    SciTech Connect (OSTI)

    Joseph, A.; Seuntjens, J.; Parker, W.; Kildea, J.; Freeman, C.

    2014-08-15

    We describe development of automated, web-based, electronic health record (EHR) auditing software for use within our paperless radiation oncology clinic. By facilitating access to multiple databases within the clinic, each patient's EHR is audited prior to treatment, regularly during treatment, and post treatment. Anomalies such as missing documentation, non-compliant workflow and treatment parameters that differ significantly from the norm may be monitored, flagged and brought to the attention of clinicians. By determining historical trends using existing patient data and by comparing new patient data with the historical, we expect our software to provide a measurable improvement in the quality of radiotherapy at our centre.

  11. Ethanol Pathways in the 2050 North American Transportation Futures Study

    SciTech Connect (OSTI)

    2009-01-18

    A paper discussing the various ethanol pathways in the 2050 North American Transportation Futures Study

  12. Syngas Upgrading to Hydrocarbon Fuels Technology Pathway

    SciTech Connect (OSTI)

    Talmadge, M.; Biddy, Mary J.; Dutta, Abhijit; Jones, Susanne B.; Meyer, Pimphan A.

    2013-03-31

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to hydrocarbon fuels to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This pathway case investigates the upgrading of biomass derived synthesis gas (‘syngas’) to hydrocarbon biofuels. While this specific discussion focuses on the conversion of syngas via a methanol intermediate to hydrocarbon blendstocks, there are a number of alternative conversion routes for production of hydrocarbons through a wide array of intermediates from syngas. Future work will also consider the variations to this pathway to determine the most economically viable and risk adverse conversion route. Technical barriers and key research needs have been identified that should be pursued for the syngas to hydrocarbon pathway to be competitive with petroleum-derived gasoline, diesel and jet range blendstocks.

  13. Whole Algae Hydrothermal Liquefaction Technology Pathway

    SciTech Connect (OSTI)

    Biddy, M.; Davis, R.; Jones, S.

    2013-03-01

    This technology pathway case investigates the feasibility of using whole wet microalgae as a feedstock for conversion via hydrothermal liquefaction. Technical barriers and key research needs have been assessed in order for the hydrothermal liquefaction of microalgae to be competitive with petroleum-derived gasoline-, diesel-, and jet-range hydrocarbon blendstocks.

  14. Corporate Analysis of DOE Safety Performance

    Broader source: Energy.gov [DOE]

    The Office of Environment, Health, Safety and Security (EHSS), Office of Analysis develops analysis tools and performance dashboards, and conducts analysis of DOE safety performance corporately and on a variety of specific environment, safety and health topics.

  15. AIR AND RADON PATHWAY MODELING FOR THE F AREA TANK FARM

    SciTech Connect (OSTI)

    Dixon, K.; Phifer, M.

    2010-07-30

    An air and radon pathways analysis was conducted for the F-Area Tank Farm (FTF) to estimate the flux of volatile radionuclides and radon at the ground surface due to residual waste remaining in the tanks following closure. This analysis was used as the basis to estimate the dose to the maximally exposed individual (MEI) for the air pathway per Curie (Ci) of each radionuclide remaining in the combined FTF waste tanks. For the air pathway analysis, several gaseous radionuclides were considered. These included carbon-14 (C-14), chlorine-36 (Cl-36), iodine-129 (I-129), selenium-79 (Se-79), antimony-125 (Sb-125), tin-126 (Sn-126), tritium (H-3), and technetium-99 (Tc-99). The dose to the MEI was estimated at the SRS Boundary during the 100 year institutional control period. For the 10,000 year post closure compliance period, the dose to the MEI was estimated at the 100 m compliance point. Additionally, the dose to the MEI was estimated at a seepage outcrop located 1600 m from the facility. For the radon pathway analysis, five parent radionuclides and their progeny were analyzed. These parent radionuclides included uranium-238 (U-238), plutonium-238 (Pu-238), uranium-234 (U-234), thorium-230 (Th-230), and radium-226 (Ra-226). The peak flux of radon-222 due to each parent radionuclide was estimated for the simulation period of 10,100 years.

  16. Behavioral Health Insurance Plan

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Behavioral Health Behavioral Health Preauthorization from BCBSNM is required for all behavioral health services. Contact Behavioral Health Unit Mental health services for retirees BlueCross BlueShield of New Mexico (BCBSNM) helps LANL employees identify and benefit from the mental health and substance abuse services they may need through a network of providers, programs and facilities. Use the BCBSNM Provider Finder to select an independently contracted and licensed behavioral health

  17. LWRS Fuels Pathway: Engineering Design and Fuels Pathway Initial Testing of the Hot Water Corrosion System

    SciTech Connect (OSTI)

    Dr. John Garnier; Dr. Kevin McHugh

    2012-09-01

    The Advanced LWR Nuclear Fuel Development R&D pathway performs strategic research focused on cladding designs leading to improved reactor core economics and safety margins. The research performed is to demonstrate the nuclear fuel technology advancements while satisfying safety and regulatory limits. These goals are met through rigorous testing and analysis. The nuclear fuel technology developed will assist in moving existing nuclear fuel technology to an improved level that would not be practical by industry acting independently. Strategic mission goals are to improve the scientific knowledge basis for understanding and predicting fundamental nuclear fuel and cladding performance in nuclear power plants, and to apply this information in the development of high-performance, high burn-up fuels. These will result in improved safety, cladding, integrity, and nuclear fuel cycle economics. To achieve these goals various methods for non-irradiated characterization testing of advanced cladding systems are needed. One such new test system is the Hot Water Corrosion System (HWCS) designed to develop new data for cladding performance assessment and material behavior under simulated off-normal reactor conditions. The HWCS is capable of exposing prototype rodlets to heated, high velocity water at elevated pressure for long periods of time (days, weeks, months). Water chemistry (dissolved oxygen, conductivity and pH) is continuously monitored. In addition, internal rodlet heaters inserted into cladding tubes are used to evaluate repeated thermal stressing and heat transfer characteristics of the prototype rodlets. In summary, the HWCS provides rapid ex-reactor evaluation of cladding designs in normal (flowing hot water) and off-normal (induced cladding stress), enabling engineering and manufacturing improvements to cladding designs before initiation of the more expensive and time consuming in-reactor irradiation testing.

  18. Whole Algae Hydrothermal Liquefaction Technology Pathway

    SciTech Connect (OSTI)

    Biddy, Mary J.; Davis, Ryan; Jones, Susanne B.; Zhu, Yunhua

    2013-03-31

    In support of the Bioenergy Technologies Office, the National Renewable Energy Laboratory (NREL) and the Pacific Northwest National Laboratory (PNNL) are undertaking studies of biomass conversion technologies to hydrocarbon fuels to identify barriers and target research toward reducing conversion costs. Process designs and preliminary economic estimates for each of these pathway cases were developed using rigorous modeling tools (Aspen Plus and Chemcad). These analyses incorporated the best information available at the time of development, including data from recent pilot and bench-scale demonstrations, collaborative industrial and academic partners, and published literature and patents. This pathway case investigates the feasibility of using whole wet microalgae as a feedstock for conversion via hydrothermal liquefaction. Technical barriers and key research needs have been assessed in order for the hydrothermal liquefaction of microalgae to be competitive with petroleum-derived gasoline, diesel and jet range blendstocks.

  19. Ad Lucem: Modeling Market Transformation Pathways Workshop

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AD LUCEM ... TOWARD THE LIGHT! 1 Ad Lucem: Modeling Market Transformation Pathways Workshop Berkeley, California | Friday, February 17, 2012 Ad lucem - Latin for toward the light - captures the essence of the SunShot Initiative. We seek to accelerate the global transition to clean, abundant solar energy by expanding our understanding of the technology-society-economics nexus. The ability to control energy resources is the enabler for growth, development, and opportunity. The diffusion of

  20. Controlling degradation pathways in organic electrochemistry via

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    redox-mediated Li+ coordination - Joint Center for Energy Storage Research March 24, 2016, Research Highlights Controlling degradation pathways in organic electrochemistry via redox-mediated Li+ coordination Scientific Achievement Exhaustive DFT experiments are well-matched to in-situ spectroscopic data showing Li+ coordination to basic methoxy groups. Li+ coordination promotes improved redox reversibility within Li+ electrolytes. Significance and Impact Redox-mediated Li+ interactions are

  1. Pathways, Networks and Systems Medicine Conferences

    SciTech Connect (OSTI)

    Nadeau, Joseph H.

    2013-11-25

    The 6th Pathways, Networks and Systems Medicine Conference was held at the Minoa Palace Conference Center, Chania, Crete, Greece (16-21 June 2008). The Organizing Committee was composed of Joe Nadeau (CWRU, Cleveland), Rudi Balling (German Research Centre, Brauschweig), David Galas (Institute for Systems Biology, Seattle), Lee Hood (Institute for Systems Biology, Seattle), Diane Isonaka (Seattle), Fotis Kafatos (Imperial College, London), John Lambris (Univ. Pennsylvania, Philadelphia),Harris Lewin (Univ. of Indiana, Urbana-Champaign), Edison Liu (Genome Institute of Singapore, Singapore), and Shankar Subramaniam (Univ. California, San Diego). A total of 101 individuals from 21 countries participated in the conference: USA (48), Canada (5), France (5), Austria (4), Germany (3), Italy (3), UK (3), Greece (2), New Zealand (2), Singapore (2), Argentina (1), Australia (1), Cuba (1), Denmark (1), Japan (1), Mexico (1), Netherlands (1), Spain (1), Sweden (1), Switzerland (1). With respect to speakers, 29 were established faculty members and 13 were graduate students or postdoctoral fellows. With respect to gender representation, among speakers, 13 were female and 28 were male, and among all participants 43 were female and 58 were male. Program these included the following topics: Cancer Pathways and Networks (Day 1), Metabolic Disease Networks (Day 2), Day 3 ? Organs, Pathways and Stem Cells (Day 3), and Day 4 ? Inflammation, Immunity, Microbes and the Environment (Day 4). Proceedings of the Conference were not published.

  2. EIS-0465: Mid-Atlantic Power Pathway Transmission Line Project...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    5: Mid-Atlantic Power Pathway Transmission Line Project in Maryland and Delaware EIS-0465: Mid-Atlantic Power Pathway Transmission Line Project in Maryland and Delaware March 4, ...

  3. Appendix A: Office Technology Pathway Structure, Bioenergy Technologie...

    Broader source: Energy.gov (indexed) [DOE]

    A-1 Last updated: November 2014 Appendix A: Technology Pathway Structure High-level block flow diagrams for each biorefinery pathway are presented in Figures A-1 through A-5....

  4. Pathways to Solar Hydrogen Technologies Leiden, The Netherlands...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pathways to Solar Hydrogen Technologies Leiden, The Netherlands) Pathways to Solar Hydrogen Technologies Leiden, The Netherlands) Mon, Jun 13, 2016 11:30am 11:30 Fri, Jun 17, 2016 ...

  5. Feedstock Pathways for Bio-oil and Syngas Conversi (Technical...

    Office of Scientific and Technical Information (OSTI)

    Feedstock Pathways for Bio-oil and Syngas Conversi Citation Details In-Document Search Title: Feedstock Pathways for Bio-oil and Syngas Conversi You are accessing a document ...

  6. NETL: SOFC Systems Analysis

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Analysis NETL possesses strong systems analysis and policy support capabilities. Systems analysis support of the SOFC Program consists of conducting various energy analyses that provide input to decisions on issues such as national plans and programs, resource use, environmental and energy security policies, technology options for R&D programs and pathways to the commercialization and deployment of SOFC power systems. Here is a partial listing of SOFC systems analysis: Techno-Economic

  7. PROJECT PROFILE: Ecolibrium3 (Solar Market Pathways) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Ecolibrium3 (Solar Market Pathways) PROJECT PROFILE: Ecolibrium3 (Solar Market Pathways) Title: Local Energy Matters: Solar Market Development in Duluth, MN Ecolibrium3.png Funding Opportunity: Solar Market Pathways SunShot Subprogram: Soft Costs Location: Duluth, MN Amount Awarded: $209,005 Awardee Cost Share: $52,266 Ecolibrium3's "Local Energy Matters" Solar Market Pathways project is working with state and local stakeholders to further develop residential rooftop, community, and

  8. Biological Conversion of Sugars to Hydrocarbons Technology Pathway |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy to Hydrocarbons Technology Pathway Biological Conversion of Sugars to Hydrocarbons Technology Pathway This technology pathway case investigates the biological conversion of biomass-derived sugars to hydrocarbon biofuels, utilizing data from recent literature references and information consistent with recent pilot-scale demonstrations at NREL. Technical barriers and key research needs have been identified that should be pursued for the pathway to become competitive with

  9. Ad Lucem: Modeling Market Transformation Pathways Workshop | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Market Transformation Pathways Workshop Ad Lucem: Modeling Market Transformation Pathways Workshop This white paper summarizes the information discussed during the Ad Lucem: Modeling Market Transformation Pathways Workshop, Feb. 17, 2012, in Berkeley, California. adlucem2012_whitepaper.pdf (547.71 KB) More Documents & Publications Ad Lucem: Modeling of Market Transformation Pathways Workshop Agenda Ad Lucem Workshop Welcome Materials from 2014 SunShot Summit BREAKOUT SESSION: THE

  10. Ad Lucem: Modeling of Market Transformation Pathways Workshop Agenda |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy of Market Transformation Pathways Workshop Agenda Ad Lucem: Modeling of Market Transformation Pathways Workshop Agenda This document details the agenda for the DOE Ad Lucem: Modeling of Market Transformation Pathways Workshop on Feb. 17, 2012. adlucem2012_agenda.pdf (295.01 KB) More Documents & Publications Ad Lucem Workshop Welcome Ad Lucem: Modeling Market Transformation Pathways Workshop The Ad Lucem Research Network

  11. Algal Lipid Extraction and Upgrading to Hydrocarbons Technology Pathway |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy Lipid Extraction and Upgrading to Hydrocarbons Technology Pathway Algal Lipid Extraction and Upgrading to Hydrocarbons Technology Pathway This technology pathway case investigates the cultivation of algal biomass followed by further lipid extraction and upgrading to hydrocarbon biofuels. Technical barriers and key research needs have been assessed in order for the algal lipid extraction and upgrading pathway to be competitive with petroleum-derived gasoline-, diesel-,

  12. Career Pathways Frequently Asked Questions (FAQs) | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Career Pathways Frequently Asked Questions (FAQs) Career Pathways Frequently Asked Questions (FAQs) The following frequently asked questions were developed by OPM's Student Programs Office. They will clarify the use of the authority and assist managers, supervisors, and human resources professionals in effectively administering the Career Pathways Program. Career Pathways FAQs (343.17 KB) Responsible Contacts Kimberly Chappell SUPERVISORY HUMAN RESOURCES SPECIALIST E-mail

  13. Catalytic Upgrading of Sugars to Hydrocarbons Technology Pathway |

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Department of Energy of Sugars to Hydrocarbons Technology Pathway Catalytic Upgrading of Sugars to Hydrocarbons Technology Pathway This technology pathway case investigates the catalytic conversion of solubilized carbohydrate streams to hydrocarbon biofuels, utilizing data from recent efforts within the National Advanced Biofuels Consortium (NABC) in collaboration with Virent, Inc. Technical barriers and key research needs that should be pursued for the catalytic conversion of sugars pathway

  14. Health.PDF

    Energy Savers [EERE]

    at that time to determine if contractor employee health benefit costs were reasonable. ... its fair share of management and operating contractors' employee health benefit costs. ...

  15. Minneapolis, Minnesota: Energy Pathways Project | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Minneapolis, Minnesota: Energy Pathways Project Minneapolis, Minnesota: Energy Pathways Project This presentation features Brian Ross, a consultant for the City of Minneapolis, Minnesota with CR Planning. Ross provides an overview of how Minneapolis created a local energy vision for its Energy Pathways Project. View the presentation above or read the transcript

  16. Environment, Safety, and Health Reporting

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2003-08-19

    To ensure timely collection, reporting, analysis, and dissemination of information on environment, safety, and health issues as required by law or regulations or as needed to ensure that the Department of Energy (DOE) and National Nuclear Security Administration (NNSA) are kept fully informed on a timely basis about events that could adversely affect the health and safety of the public or the workers, the environment, the intended purpose of DOE facilities, or the credibility of the Department. Cancels DOE O 210.1, DOE O 231.1, and DOE O 232.1A. Canceled by DOE O 232.2.

  17. Curation and Computational Design of Bioenergy-Related Metabolic Pathways

    SciTech Connect (OSTI)

    Karp, Peter D.

    2014-09-12

    Pathway Tools is a systems-biology software package written by SRI International (SRI) that produces Pathway/Genome Databases (PGDBs) for organisms with a sequenced genome. Pathway Tools also provides a wide range of capabilities for analyzing predicted metabolic networks and user-generated omics data. More than 5,000 academic, industrial, and government groups have licensed Pathway Tools. This user community includes researchers at all three DOE bioenergy centers, as well as academic and industrial metabolic engineering (ME) groups. An integral part of the Pathway Tools software is MetaCyc, a large, multiorganism database of metabolic pathways and enzymes that SRI and its academic collaborators manually curate. This project included two main goals: I. Enhance the MetaCyc content of bioenergy-related enzymes and pathways. II. Develop computational tools for engineering metabolic pathways that satisfy specified design goals, in particular for bioenergy-related pathways. In part I, SRI proposed to significantly expand the coverage of bioenergy-related metabolic information in MetaCyc, followed by the generation of organism-specific PGDBs for all energy-relevant organisms sequenced at the DOE Joint Genome Institute (JGI). Part I objectives included: 1: Expand the content of MetaCyc to include bioenergy-related enzymes and pathways. 2: Enhance the Pathway Tools software to enable display of complex polymer degradation processes. 3: Create new PGDBs for the energy-related organisms sequenced by JGI, update existing PGDBs with new MetaCyc content, and make these data available to JBEI via the BioCyc website. In part II, SRI proposed to develop an efficient computational tool for the engineering of metabolic pathways. Part II objectives included: 4: Develop computational tools for generating metabolic pathways that satisfy specified design goals, enabling users to specify parameters such as starting and ending compounds, and preferred or disallowed intermediate compounds

  18. Funding Opportunity Announcement: Solar Market Pathways

    Broader source: Energy.gov [DOE]

    The Solar Market Pathways funding opportunity announcement (FOA) seeks to support regional, state, tribal, and locally-driven efforts to develop multi-year solar deployment plans that will help provide business certainty and establish a clear path for the next five to ten years of solar deployment. Specifically, this FOA is intended to enable replicable multi-year strategies that spur significant solar deployment, drive down solar soft costs, support local economic development efforts, and address the potential challenges arising from increased solar penetration on the electrical grid.

  19. Environment/Health/Safety (EHS): Monthly Accident Statistics

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Personal Protective Equipment (PPE) Injury Review & Analysis Worker Safety and Health Program: PUB-3851 Monthly Accident Statistics Latest Accident Statistics Accident...

  20. Environment, Safety and Health Reporting

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2012-01-01

    To ensure timely collection, reporting, analysis, and dissemination of information on environment, safety, and health issues as required by law or regulations or as needed to ensure that the Department of Energy (DOE) and National Nuclear Security Administration are kept fully informed on a timely basis about events that could adversely affect the health and safety of the public or the workers, the environment, the intended purpose of DOE facilities, or the credibility of the Department. Cancels DOE O 210.1, DOE O 231.1, DOE O 232.1A. Canceled by DOE O 231.1B. DOE O 231.1B cancels all portions pertaining to environment, safety, and health reporting. Occurrence reporting and processing of operations information provisions remain in effect until January 1, 2012.

  1. ORISE: Worker Health Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Worker Health Research Worker Health Research The Oak Ridge Institute for Science and Education (ORISE) provides technical assistance to the U.S. Department of Energy (DOE) and other government agencies by performing specialized worker health research to assess the health of workers and other populations. Statistical methods, epidemiologic research and hazard assessments are core ORISE worker health research competencies. Because information technology is an integral part of the epidemiologic

  2. Occupational Health Services - HPMC Occupational Health Services

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    exercise physiology and work conditioning, monitored care and case management, fitness for duty evaluations, health education and wellness promotion, infection control,...

  3. USDOE study: Human health and ecological risk assessment for produced water discharges

    SciTech Connect (OSTI)

    Meinhold, A.F.; Holtzman, S.; DePhillips, M.; Hamilton, L.D.

    1994-12-31

    Produced water generated during the production of oil and gas can contain high concentrations of radionuclides, organics and heavy metals. There are concerns about potential human health and ecological impacts from the discharge of these contaminants to the Gulf of Mexico. Data collected in the United States Department of Energy (USDOE) field study are being used in a series of human health and ecological risk assessments. These assessments will support scientifically-based regulation and risk management. This presentation: summarizes risk assessments performed for produced water discharges; describes how uncertainties in these assessments are guiding data collection efforts in the USDOE field study; and outlines ongoing risk assessment studies. In these studies, risk assessment is treated as an iterative process. An initial screening-level assessment is performed to identify important contaminants, transport and exposure pathways, and parameters. These intermediate results are used to guide data collection efforts and refinements to the analysis. At this stage in the analysis, risk is described in terms of probabilities; the uncertainties in each measured or modeled parameter are considered explicitly.

  4. Robust, High-Throughput Analysis of Protein Structures

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    applying SAXS to focused biological problems. Current directions include the analysis of DNA repair pathways, which, if malfunctioning, are a leading cause of cancer. An equally...

  5. Climate Change Mitigation: An Analysis of Advanced Technology Scenarios

    SciTech Connect (OSTI)

    Clarke, Leon E.; Wise, Marshall A.; Placet, Marylynn; Izaurralde, R Cesar; Lurz, Joshua P.; Kim, Son H.; Smith, Steven J.; Thomson, Allison M.

    2006-09-18

    This report documents a scenario analysis that explores three advanced technology pathways toward climate stabilization using the MiniCAM model.

  6. Systems Analysis Workshop Agenda | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Agenda Systems Analysis Workshop Agenda Agenda from DOE Systems Analysis Workshop held in Washington, D.C. July 28-29, 2004 to discuss and define role of systems analysis in DOE Hydrogen Program. saw_agenda.pdf (113.03 KB) More Documents & Publications Systems Analysis Workshop Welcome & Introductions Fuel Pathways Integration Tech Team Systems Analysis Workshop Purpose

  7. Multistage reaction pathways in detonating high explosives

    SciTech Connect (OSTI)

    Li, Ying; Kalia, Rajiv K.; Nakano, Aiichiro; Nomura, Ken-ichi; Vashishta, Priya

    2014-11-17

    Atomistic mechanisms underlying the reaction time and intermediate reaction products of detonating high explosives far from equilibrium have been elusive. This is because detonation is one of the hardest multiscale physics problems, in which diverse length and time scales play important roles. Here, large spatiotemporal-scale reactive molecular dynamics simulations validated by quantum molecular dynamics simulations reveal a two-stage reaction mechanism during the detonation of cyclotrimethylenetrinitramine crystal. Rapid production of N{sub 2} and H{sub 2}O within ?10 ps is followed by delayed production of CO molecules beyond ns. We found that further decomposition towards the final products is inhibited by the formation of large metastable carbon- and oxygen-rich clusters with fractal geometry. In addition, we found distinct unimolecular and intermolecular reaction pathways, respectively, for the rapid N{sub 2} and H{sub 2}O productions.

  8. Using the Gene Ontology to Enrich Biological Pathways

    SciTech Connect (OSTI)

    Sanfilippo, Antonio P.; Baddeley, Robert L.; Beagley, Nathaniel; McDermott, Jason E.; Riensche, Roderick M.; Taylor, Ronald C.; Gopalan, Banu

    2009-12-10

    Most current approaches to automatic pathway generation are based on a reverse engineering approach in which pathway plausibility is solely derived from microarray gene expression data. These approaches tend to lack in generality and offer no independent validation as they are too reliant on the pathway observables that guide pathway generation. By contrast, alternative approaches that use prior biological knowledge to validate pathways inferred from gene expression data may err in the opposite direction as the prior knowledge is usually not sufficiently tuned to the pathology of focus. In this paper, we present a novel pathway generation approach that combines insights from the reverse engineering and knowledge-based approaches to increase the biological plausibility of automatically generated regulatory networks and describe an application of this approach to transcriptional data from a mouse model of neuroprotection during stroke.

  9. Pathways Toward Sustainable Bioenergy Feedstock Production in the Mississippi River Watershed

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathways Toward Sustainable Bioenergy Feedstock Production in the Mississippi River Watershed March 24, 2015 Analysis and Sustainability Review Jason Hill University of Minnesota This presentation does not contain any proprietary, confidential, or otherwise restricted information Goal Statement * The overall goal of this project is to use an ecosystem service framework to evaluate the environmental impact of biomass production options and their placement on the landscape so as to guide the

  10. Whole Algae Hydrothermal Liquefaction Technology Pathway | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Liquefaction Technology Pathway Whole Algae Hydrothermal Liquefaction Technology Pathway This technology pathway case investigates the feasibility of using whole wet microalgae as a feedstock for conversion via hydrothermal liquefaction. Technical barriers and key research needs have been assessed in order for the hydrothermal liquefaction of microalgae to be competitive with petroleum-derived gasoline-, diesel-, and jet-range hydrocarbon blendstocks. Whole Algae Hydrothermal

  11. Syngas Upgrading to Hydrocarbon Fuels Technology Pathway | Department of

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Energy Syngas Upgrading to Hydrocarbon Fuels Technology Pathway Syngas Upgrading to Hydrocarbon Fuels Technology Pathway This technology pathway case investigates the upgrading of woody biomass derived synthesis gas (syngas) to hydrocarbon biofuels. While this specific discussion focuses on the conversion of syngas via a methanol intermediate to hydrocarbon blendstocks, there are a number of alternative conversion routes for production of hydrocarbons through a wide array of intermediates

  12. WIPP Concludes Zone Recovery Activities for Panel 7 Disposal Pathway

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    24, 2015 WIPP Concludes Zone Recovery Activities for Panel 7 Disposal Pathway After months of catch-up rock bolting and contamination mitigation, zone recovery activities along the pathway to Panel 7 have been completed. Panel 7, which consists of seven disposal rooms (see map below), will be the active disposal area when waste emplacement activities resume. Initial closure of Panel 7 Room 7 was completed in May 2015. Although the pathway has been established, a significant number of activities,

  13. Algal Lipid Extraction and Upgrading to Hydrocarbons Technology Pathway

    Office of Scientific and Technical Information (OSTI)

    (Technical Report) | SciTech Connect Algal Lipid Extraction and Upgrading to Hydrocarbons Technology Pathway Citation Details In-Document Search Title: Algal Lipid Extraction and Upgrading to Hydrocarbons Technology Pathway This technology pathway case investigates the cultivation of algal biomass followed by further lipid extraction and upgrading to hydrocarbon biofuels. Technical barriers and key research needs have been assessed in order for the algal lipid extraction and upgrading

  14. Whole Algae Hydrothermal Liquefaction Technology Pathway (Technical Report)

    Office of Scientific and Technical Information (OSTI)

    | SciTech Connect Technical Report: Whole Algae Hydrothermal Liquefaction Technology Pathway Citation Details In-Document Search Title: Whole Algae Hydrothermal Liquefaction Technology Pathway This technology pathway case investigates the feasibility of using whole wet microalgae as a feedstock for conversion via hydrothermal liquefaction. Technical barriers and key research needs have been assessed in order for the hydrothermal liquefaction of microalgae to be competitive with

  15. Fusing the Audacity of Imagination with Pathways to Excellence | Department

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    of Energy Fusing the Audacity of Imagination with Pathways to Excellence Fusing the Audacity of Imagination with Pathways to Excellence April 6, 2016 - 1:39pm Addthis Awardees and distinguished guests at PNNL’s Pathway to Excellence Celebration are (left to right) Jud Virden, Associate Laboratory Director, Energy and Environment, Malin Young, Deputy Director for Science and Technology, Jetta Wong, Director for the Office of Technology Transitions, Shari Li, Distinguished Inventor of

  16. Associations of blood lead, cadmium, and mercury with estimated glomerular filtration rate in the Korean general population: Analysis of 2008-2010 Korean National Health and Nutrition Examination Survey data

    SciTech Connect (OSTI)

    Kim, Yangho; Lee, Byung-Kook

    2012-10-15

    Introduction: The objective of this study was to evaluate associations between blood lead, cadmium, and mercury levels with estimated glomerular filtration rate in a general population of South Korean adults. Methods: This was a cross-sectional study based on data obtained in the Korean National Health and Nutrition Examination Survey (KNHANES) (2008-2010). The final analytical sample consisted of 5924 participants. Estimated glomerular filtration rate (eGFR) was calculated using the MDRD Study equation as an indicator of glomerular function. Results: In multiple linear regression analysis of log2-transformed blood lead as a continuous variable on eGFR, after adjusting for covariates including cadmium and mercury, the difference in eGFR levels associated with doubling of blood lead were -2.624 mL/min per 1.73 m Superscript-Two (95% CI: -3.803 to -1.445). In multiple linear regression analysis using quartiles of blood lead as the independent variable, the difference in eGFR levels comparing participants in the highest versus the lowest quartiles of blood lead was -3.835 mL/min per 1.73 m Superscript-Two (95% CI: -5.730 to -1.939). In a multiple linear regression analysis using blood cadmium and mercury, as continuous or categorical variables, as independent variables, neither metal was a significant predictor of eGFR. Odds ratios (ORs) and 95% CI values for reduced eGFR calculated for log2-transformed blood metals and quartiles of the three metals showed similar trends after adjustment for covariates. Discussion: In this large, representative sample of South Korean adults, elevated blood lead level was consistently associated with lower eGFR levels and with the prevalence of reduced eGFR even in blood lead levels below 10 {mu}g/dL. In conclusion, elevated blood lead level was associated with lower eGFR in a Korean general population, supporting the role of lead as a risk factor for chronic kidney disease.

  17. Pathways to Hydrocarbon Biofuels: Update on the Office's Techno...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Pathway TEA - Sustainability Coordination Design Report Environmental Sustainability Metrics GHG emissions kg CO2eGJ Conversion Plant Fossil Energy Consumption MJMJ ...

  18. Pathways to Commercial Success: Technologies and Products Supported...

    Office of Scientific and Technical Information (OSTI)

    the Fuel Cell Technologies Office - 2015 Citation Details In-Document Search Title: Pathways to Commercial Success: Technologies and Products Supported by the Fuel Cell ...

  19. 2009 Pathways to Commercial Success: Technologies and Products...

    Office of Environmental Management (EM)

    Office of Energy Efficiency and Renewable Energy. 2009 Pathways to Commercial Success: Technologies and Products Supported by the Hydrogen, Fuel Cells and Infrastructure ...

  20. CBEI: Career Pathways for the Energy Retrofit Workforce - 2015...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    CBEI: Career Pathways for the Energy Retrofit Workforce - 2015 Peer Review (2.3 MB) More Documents & Publications Advanced Critical Advanced Energy Retrofit Education and Training ...

  1. Prioritizing Acquisition Pathways in the State Level Concept...

    Office of Scientific and Technical Information (OSTI)

    activities and the State evaluation process to draw safeguards conclusions ... proliferation pathways based on an assessment of a State's capabilities and assumed ...

  2. Identification of Low Emissions Agricultural Pathways and Priorities...

    Open Energy Info (EERE)

    Pathways and Priorities for Mitigation in Agricultural Landscapes using Integrated Assessment Modeling and Scenarios Jump to: navigation, search Name Identification of Low...

  3. BETO Announces Notice of Intent (NOI) to Develop Pathways to...

    Broader source: Energy.gov (indexed) [DOE]

    opportunity announcement (FOA) entitled "MEGA-BIO: Bioproducts to Enable Biofuels." ... pathways that produce biofuels, with little or no emphasis on coproducing bioproducts. ...

  4. A Metabolic Pathway in Cyanobacteria Could Yield Better Biofuels...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    A Metabolic Pathway in Cyanobacteria Could Yield Better Biofuels and Bioproducts from ... chemicals that can be used to produce a variety of bio-based chemicals and biofuels. ...

  5. A General Strategy for the Discovery of Metabolic Pathways: d...

    Office of Scientific and Technical Information (OSTI)

    Title: A General Strategy for the Discovery of Metabolic Pathways: d-Threitol, l-Threitol, and Erythritol Utilization in Mycobacterium smegmatis Authors: Huang, Hua ; Carter, ...

  6. Emissions pathways, climate change, and impacts on California...

    Office of Scientific and Technical Information (OSTI)

    Journal Article: Emissions pathways, climate change, and impacts on California Citation ... OSTI Identifier: 831116 Report Number(s): LBNL--56119-Journal R&D Project: G31501; TRN: ...

  7. Biosensor-based engineering of biosynthetic pathways (Journal...

    Office of Scientific and Technical Information (OSTI)

    Journal Article: Biosensor-based engineering of biosynthetic pathways Citation Details ... GrantContract Number: DEFG02-02ER63445 Type: Published Article Journal Name: Current ...

  8. Pathways to Low-Cost Electrochemical Energy Storage: A Comparison...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    September 16, 2014, Research Highlights Pathways to Low-Cost Electrochemical Energy Storage: A ... First comprehensive determination of materials to system level performance and cost ...

  9. Prioritizing Acquisition Pathways in the State Level Concept...

    Office of Scientific and Technical Information (OSTI)

    Prioritizing Acquisition Pathways in the State Level Concept Citation Details In-Document ... Sponsoring Org: DOELANL Country of Publication: United States Language: English Subject: ...

  10. Biological Conversion of Sugars to Hydrocarbons Technology Pathway...

    Office of Scientific and Technical Information (OSTI)

    This technology pathway case investigates the biological conversion of biomass-derived ... Sponsoring Org: USDOE Office of Energy Efficiency and Renewable Energy Biomass Program ...

  11. Syngas Upgrading to Hydrocarbon Fuels Technology Pathway (Technical...

    Office of Scientific and Technical Information (OSTI)

    This technology pathway case investigates the upgrading of woody biomass derived synthesis ... Sponsoring Org: USDOE Office of Energy Efficiency and Renewable Energy Biomass Program ...

  12. In-Situ Catalytic Fast Pyrolysis Technology Pathway (Technical...

    Office of Scientific and Technical Information (OSTI)

    This technology pathway case investigates converting woody biomass using in-situ catalytic ... Sponsoring Org: USDOE Office of Energy Efficiency and Renewable Energy Biomass Program ...

  13. Ex-Situ Catalytic Fast Pyrolysis Technology Pathway (Technical...

    Office of Scientific and Technical Information (OSTI)

    This technology pathway case investigates converting woody biomass using ex-situ catalytic ... Sponsoring Org: USDOE Office of Energy Efficiency and Renewable Energy Biomass Program ...

  14. A Study of Past, Present, and Future Radiation Dose Pathways...

    Office of Scientific and Technical Information (OSTI)

    Study of Past, Present, and Future Radiation Dose Pathways from Hanford Site Effluents Citation Details In-Document Search Title: A Study of Past, Present, and Future Radiation ...

  15. Bioenergy Technologies Office R&D Pathways: Algal Lipid Upgrading...

    Office of Environmental Management (EM)

    Algal Lipid Upgrading Bioenergy Technologies Office R&D Pathways: Algal Lipid Upgrading ... chosen to convert biomass into hydrocarbon fuels by the Bioenergy Technologies Office. ...

  16. Monitoring Long-Range Electron Transfer Pathways in Proteins...

    Office of Scientific and Technical Information (OSTI)

    Published Article: Monitoring Long-Range Electron Transfer Pathways in Proteins by Stimulated Attosecond Broadband X-ray Raman Spectroscopy Title: Monitoring Long-Range Electron ...

  17. Quantum control and pathway manipulation in rubidium (Journal...

    Office of Scientific and Technical Information (OSTI)

    Quantum control and pathway manipulation in rubidium Citation Details In-Document Search This content will become publicly available on September 28, 2016 Title: Quantum control ...

  18. A Multidisciplinary Approach To Detect Active Pathways For Magma...

    Open Energy Info (EERE)

    Multidisciplinary Approach To Detect Active Pathways For Magma Migration And Eruption At Mt Etna (Sicily, Italy) Before The 2001 And 2002-2003 Eruptions Jump to: navigation, search...

  19. Hawaii Department of Health Indoor and Radiological Health Branch...

    Open Energy Info (EERE)

    Indoor and Radiological Health Branch Jump to: navigation, search Name: Hawaii Department of Health Indoor and Radiological Health Branch From Open Energy Information Address: 591...

  20. Browse by Discipline -- E-print Network Subject Pathways: Computer...

    Office of Scientific and Technical Information (OSTI)

    - Centre for Bayesian Statistics in Health Economics & Department of Probability and ... A. (Richard A. Olshen) - Departments of Health Research and Policy & Statistics, ...

  1. Update of Part 61 Impacts Analysis Methodology. Methodology report. Volume 1

    SciTech Connect (OSTI)

    Oztunali, O.I.; Roles, G.W.

    1986-01-01

    Under contract to the US Nuclear Regulatory Commission, the Envirosphere Company has expanded and updated the impacts analysis methodology used during the development of the 10 CFR Part 61 rule to allow improved consideration of the costs and impacts of treatment and disposal of low-level waste that is close to or exceeds Class C concentrations. The modifications described in this report principally include: (1) an update of the low-level radioactive waste source term, (2) consideration of additional alternative disposal technologies, (3) expansion of the methodology used to calculate disposal costs, (4) consideration of an additional exposure pathway involving direct human contact with disposed waste due to a hypothetical drilling scenario, and (5) use of updated health physics analysis procedures (ICRP-30). Volume 1 of this report describes the calculational algorithms of the updated analysis methodology.

  2. Ex-Situ Catalytic Fast Pyrolysis Technology Pathway

    SciTech Connect (OSTI)

    Biddy, M.; Dutta, A.; Jones, S.; Meyer, A.

    2013-03-01

    This technology pathway case investigates converting woody biomass using ex-situ catalytic fast pyrolysis followed by upgrading to gasoline-, diesel-, and jet-range hydrocarbon blendstocks. Technical barriers and key research needs that should be pursued for this pathway to be competitive with petroleum-derived blendstocks have been identified.

  3. In-Situ Catalytic Fast Pyrolysis Technology Pathway

    SciTech Connect (OSTI)

    Biddy, M.; Dutta, A.; Jones, S.; Meyer, A.

    2013-03-01

    This technology pathway case investigates converting woody biomass using in-situ catalytic fast pyrolysis followed by upgrading to gasoline-, diesel-, and jet-range hydrocarbon blendstocks. Technical barriers and key research needs that should be pursued for this pathway to be competitive with petroleum-derived blendstocks have been identified.

  4. Algal Lipid Extraction and Upgrading to Hydrocarbons Technology Pathway

    SciTech Connect (OSTI)

    Davis, R.; Biddy, M.; Jones, S.

    2013-03-01

    This technology pathway case investigates the cultivation of algal biomass followed by further lipid extraction and upgrading to hydrocarbon biofuels. Technical barriers and key research needs have been assessed in order for the algal lipid extraction and upgrading pathway to be competitive with petroleum-derived gasoline-, diesel-, and jet-range hydrocarbon blendstocks.

  5. Ex-Situ Catalytic Fast Pyrolysis Technology Pathway

    Broader source: Energy.gov [DOE]

    This technology pathway case investigates converting woody biomass using ex-situ catalytic fast pyrolysis followed by upgrading to gasoline-, diesel-, and jet-range hydrocarbon blendstocks. Technical barriers and key research needs that should be pursued for this pathway to be competitive with petroleum-derived blendstocks have been identified.

  6. In-Situ Catalytic Fast Pyrolysis Technology Pathway

    Broader source: Energy.gov [DOE]

    This technology pathway case investigates converting woody biomass using in-situ catalytic fast pyrolysis followed by upgrading to gasoline-, diesel-, and jet-range hydrocarbon blendstocks. Technical barriers and key research needs that should be pursued for this pathway to be competitive with petroleum-derived blendstocks have been identified.

  7. Aquatic Pathways Model to predict the fate of phenolic compounds. Appendixes A through D

    SciTech Connect (OSTI)

    Aaberg, R.L.; Peloquin, R.A.; Strenge, D.L.; Mellinger, P.L.

    1983-04-01

    Organic materials released from energy-related activities could affect human health and the environment. We have developed a model to predict the fate of spills or discharges of pollutants into flowing or static bodies of fresh water. A computer code, Aquatic Pathways Model (APM), was written to implement the model. The APM estimates the concentrations of chemicals in fish tissue, water and sediment, and is therefore useful for assessing exposure to humans through aquatic pathways. The major pathways considered are biodegradation, fish and sediment uptake, photolysis, and evaporation. The model has been implemented with parameters for the distribution of phenols, an important class of compounds found in the water-soluble fractions of coal liquids. The model was developed to estimate the fate of liquids derived from coal. Current modeling efforts show that, in comparison with many pesticides and polyaromatic hydrocarbons (PAH), the lighter phenolics (the cresols) are not persistent in the environment. For the twelve phenolics studied, biodegradation appears to be the major pathway for elimination from aquatic environments. A pond system simulation of a spill of solvent-refined coal (SRC-II) materials indicates that phenol, cresols, and other single cyclic phenolics are degraded to 16 to 25 percent of their original concentrations within 30 hours. Adsorption of these compounds into sediments and accumulation by fish was minor. Results of a simulated spill of a coal liquid (SRC-II) into a pond show that APM predicted the allocation of 12 phenolic components among six compartments at 30 hours after a small spill. The simulation indicated that most of the introduced phenolic compounds were biodegraded. The phenolics remaining in the aquatic system partitioned according to their molecular weight and structure. A substantial amount was predicted to remain in the water, with less than 0.01% distributed in sediment or fish.

  8. Cyclone-cyclone Interactions through the Ocean Pathway

    SciTech Connect (OSTI)

    Balaguru, Karthik; Taraphdar, Sourav; Leung, Lai-Yung R.; Foltz, Gregory R.; Knaff, John A.

    2014-10-16

    The intense SST (Sea Surface Temperature) cooling caused by hurricane-induced mixing is restored at timescales on the order of weeks(1) and thus may persist long enough to influence a later hurricane passing over it. Though many studies have evaluated the effects of SST cool-ing induced by a hurricane on its own intensification(2, 3), none has looked at its effect on later storms. Using an analysis of observations and numerical model simulations, we demonstrate that hurricanes may influence the intensity of later hurricanes that pass over their linger-ing wakes. On average, when hurricanes encounter cold wakes, they experience SSTs that are ~0.4oC lower than when they do not encounter wakes and consequently decay(intensify) at a rate that is nearly three times faster(slower). In the region of warm SSTs (* 26.5oC) where the most intense and damaging hurricanes tend to occur, the percentage of hurricanes that encounter lingering cold wakes increases with hurricane frequency and was found to be as high as 40%. Furthermore, we estimate that the cumulative power dissipated(4) by the most energetic hurricanes has been reduced by as much as ~7% in a season through this effect. As the debate on changes in Atlantic hurricane activity associated with global warming(5) continues, the negative feedback between hurricane frequency and intensity resulting from hurricane-hurricane interactions through the ocean pathway deserves attention.

  9. Hydrogen Production Infrastructure Options Analysis

    Broader source: Energy.gov (indexed) [DOE]

    Presentation on hydrogen pathway cost distributions presented January 25, 2006. wkshp_storage_uihlein.pdf (189.04 KB) More Documents & Publications Manufacturing Cost Analysis of 1 kW and 5 kW Solid Oxide Fuel Cell (SOFC) for Auxiliary Power Applications Natural Gas Imports and Exports First Quarter Report 2016 Pathway and Resource Overview Current Technology Status of Seven Hydrogen Production, Delivery, and Distribution Scenarios | Department of Energy

    This document reports the

  10. Bioscience: Bioenergy, Biosecurity, and Health

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Bioscience: Bioenergy, Biosecurity, and Health science-innovationassetsimagesicon-science.jpg Bioscience: Bioenergy, Biosecurity, and Health Los Alamos scientists are ...