National Library of Energy BETA

Sample records for halon suppression system

  1. Memorandum, Managed Phase Out of Halon Fixed Fire Suppression Systems- May 5, 1993

    Broader source: Energy.gov [DOE]

    The purpose of this memorandum is to provide additional interim departmental criteria on the management of the reduction and potential elimination of Halon fire extinguishing systems within the Department of Energy (DOE). This memorandum supplements the joint Office of Safety and Quality Assurance/Office of Projects and Facilities Management memorandum of September 27, 1990, in which guidance was provided on the installation of new Halon 1301 fixed fire suppression systems and halon 1211 portable fire extinguishers.

  2. Health effects of Halon 1301 exposure

    SciTech Connect (OSTI)

    Holness, D.L.; House, R.A. )

    1992-07-01

    An accidental discharge of a Halon 1301 system is reported. Thirty-one workers were assessed, 22 who were present at the time of the discharge, and 9 who worked the next shift. The incident was complicated by a small Freon-22 leak several hours later. Throat, eye, and nasal irritation and lightheadedness were reported by the majority of workers. Workers present during the halon discharge reported significantly more lightheadedness, headache, voice change, cough, and a fast heartbeat than did those who worked the later shift. These differences were significant even after correcting for confounding factors such as age, sex, and sense of anxiety at the time of the incident. The possible causes for the irritant symptoms include breakdown products of Halon 1301 and Freon-22 or contaminants from the halon discharge system. Although these irritant effects may not be an effect of Halon 1301 alone, they may occur in these discharge situations, and workers should be advised of this possibility. The possible cardiac and central nervous system effects also should be considered. The importance of a clear-cut protocol to deal with such incidents as well as worker education are discussed.

  3. Explosion suppression system

    DOE Patents [OSTI]

    Sapko, Michael J. (Finleyville, PA); Cortese, Robert A. (Pittsburgh, PA)

    1992-01-01

    An explosion suppression system and triggering apparatus therefor are provided for quenching gas and dust explosions. An electrically actuated suppression mechanism which dispenses an extinguishing agent into the path ahead of the propagating flame is actuated by a triggering device which is light powered. This triggering device is located upstream of the propagating flame and converts light from the flame to an electrical actuation signal. A pressure arming device electrically connects the triggering device to the suppression device only when the explosion is sensed by a further characteristic thereof beside the flame such as the pioneer pressure wave. The light powered triggering device includes a solar panel which is disposed in the path of the explosion and oriented between horizontally downward and vertical. Testing mechanisms are also preferably provided to test the operation of the solar panel and detonator as well as the pressure arming mechanism.

  4. Pressure suppression containment system

    DOE Patents [OSTI]

    Gluntz, Douglas M.; Townsend, Harold E.

    1994-03-15

    A pressure suppression containment system includes a containment vessel surrounding a reactor pressure vessel and defining a drywell therein containing a non-condensable gas. An enclosed wetwell pool is disposed inside the containment vessel, and a gravity driven cooling system (GDCS) pool is disposed above the wetwell pool in the containment vessel. The wetwell pool includes a plenum for receiving the non-condensable gas carried with steam from the drywell following a loss-of coolant-accident (LOCA). The wetwell plenum is vented to a plenum above the GDCS pool following the LOCA for suppressing pressure rise within the containment vessel. A method of operation includes channeling steam released into the drywell following the LOCA into the wetwell pool for cooling along with the non-condensable gas carried therewith. The GDCS pool is then drained by gravity, and the wetwell plenum is vented into the GDCS plenum for channeling the non-condensable gas thereto.

  5. Pressure suppression containment system

    DOE Patents [OSTI]

    Gluntz, D.M.; Townsend, H.E.

    1994-03-15

    A pressure suppression containment system includes a containment vessel surrounding a reactor pressure vessel and defining a drywell therein containing a non-condensable gas. An enclosed wetwell pool is disposed inside the containment vessel, and a gravity driven cooling system (GDCS) pool is disposed above the wetwell pool in the containment vessel. The wetwell pool includes a plenum for receiving the non-condensable gas carried with steam from the drywell following a loss-of-coolant-accident (LOCA). The wetwell plenum is vented to a plenum above the GDCS pool following the LOCA for suppressing pressure rise within the containment vessel. A method of operation includes channeling steam released into the drywell following the LOCA into the wetwell pool for cooling along with the non-condensable gas carried therewith. The GDCS pool is then drained by gravity, and the wetwell plenum is vented into the GDCS plenum for channeling the non-condensable gas thereto. 6 figures.

  6. Pressure suppression system

    DOE Patents [OSTI]

    Gluntz, Douglas M.

    1994-01-01

    A pressure suppression system includes a containment vessel surrounding a reactor pressure vessel and defining a drywell therein containing a non-condensable gas. An enclosed wetwell pool is disposed inside the containment vessel, and an enclosed gravity driven cooling system (GDCS) pool is disposed above the wetwell pool in the containment vessel. The GDCS pool includes a plenum for receiving through an inlet the non-condensable gas carried with steam from the drywell following a loss-of-coolant accident (LOCA). A condenser is disposed in the GDCS plenum for condensing the steam channeled therein and to trap the non-condensable gas therein. A method of operation includes draining the GDCS pool following the LOCA and channeling steam released into the drywell following the LOCA into the GDCS plenum for cooling along with the non-condensable gas carried therewith for trapping the gas therein.

  7. Pressure suppression system

    DOE Patents [OSTI]

    Gluntz, D.M.

    1994-10-04

    A pressure suppression system includes a containment vessel surrounding a reactor pressure vessel and defining a drywell therein containing a non-condensable gas. An enclosed wetwell pool is disposed inside the containment vessel, and an enclosed gravity driven cooling system (GDCS) pool is disposed above the wetwell pool in the containment vessel. The GDCS pool includes a plenum for receiving through an inlet the non-condensable gas carried with steam from the drywell following a loss-of-coolant accident (LOCA). A condenser is disposed in the GDCS plenum for condensing the steam channeled therein and to trap the non-condensable gas therein. A method of operation includes draining the GDCS pool following the LOCA and channeling steam released into the drywell following the LOCA into the GDCS plenum for cooling along with the non-condensable gas carried therewith for trapping the gas therein. 3 figs.

  8. Noise suppressing capillary separation system

    DOE Patents [OSTI]

    Yeung, Edward S. (Ames, IA); Xue, Yongjun (Norwich, NY)

    1996-07-30

    A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that generates a beam which is split into a reference beam and a sample beam that irradiate the capillary, and a detector for detecting the reference beam and the sample beam light that transmits through the capillary. The laser beam is of a wavelength effective to be absorbed by a chromophore in the capillary. The system includes a noise suppressing system to improve performance and accuracy without signal averaging or multiple scans.

  9. Noise suppressing capillary separation system

    DOE Patents [OSTI]

    Yeung, E.S.; Xue, Y.

    1996-07-30

    A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that generates a beam which is split into a reference beam and a sample beam that irradiate the capillary, and a detector for detecting the reference beam and the sample beam light that transmits through the capillary. The laser beam is of a wavelength effective to be absorbed by a chromophore in the capillary. The system includes a noise suppressing system to improve performance and accuracy without signal averaging or multiple scans. 13 figs.

  10. Blast Effects Suppression System - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Blast Effects Suppression System HydroSuppressor (TM) Battelle Memorial Institute Contact BMI About This Technology Publications: PDF Document Publication Blast Effects Suppression System Patent (162 KB) PDF Document Publication Blast Effects Suppression System Picture (33 KB) Technology Marketing Summary The HydroSuppressor system was developed to protect critical facilities from the devastating effects of blast from a vehicle bomb. HydroSuppressor uses high volume water sprays to absorb the

  11. Requirements And Instructions For Shipping Halon To The Defense Logistics Agency (DLA) Halon Repository

    Broader source: Energy.gov [DOE]

    Disposition of excess Halon 1301 is now done in accordance with Executive Order 13148 — “Greening the Government Through Leadership in Environmental Management ”, Section 505 (c). An SF-122 form (or equivalent documentation) should be approved by the DLA prior to shipment.

  12. Verification study of an emerging fire suppression system (Journal Article)

    Office of Scientific and Technical Information (OSTI)

    | DOE PAGES Verification study of an emerging fire suppression system This content will become publicly available on January 1, 2017 « Prev Next » Title: Verification study of an emerging fire suppression system Self-contained fire extinguishers are a robust, reliable and minimally invasive means of fire suppression for gloveboxes. Moreover, plutonium gloveboxes present harsh environmental conditions for polymer materials; these include radiation damage and chemical exposure, both of which

  13. Concrete Dust Suppression System. Innovative Technology Summary Report

    SciTech Connect (OSTI)

    1998-12-01

    The improved technology is a water-based dust suppression system for controlling concrete dust generated by demolition equipment, in this case a demolition ram. This demonstration was performed to assess the effectiveness of this system to (1) minimize the amount of water used to suppress potentially contaminated dust, (2) focus the water spray on the dust-generating source and (3) minimize the dust cloud generated by the demolition activity. The technology successfully reduced the water required by a factor of eight compared to the traditional (baseline) method, controlled the dust generated, and permitted a reduction in the work force. The water spray can be focused at the ram point, but it is affected by wind. Prior to the use of this dust control system, dust generated by the demolition ram was controlled manually by spraying with fire hoses (the baseline technology). The improved technology is 18% less expensive than the baseline technology for the conditions and parameters of this demonstration, however, the automated system can save up to 80% versus the baseline whenever waste water treatment costs are considered. For demolishing one high-walled room and a long slab with a total of 413 m{sup 3} (14,580 ft{sup 3}) of concrete, the savings are $105,000 (waste water treatment included). The improved technology reduced the need for water consumption and treatment by about 88% which results in most of the savings.

  14. Reliability study of an emerging fire suppression system

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Miller, David A.; Rossati, Lyric M.; Fritz, Nathan K.; Cournoyer, Michael E.; Granzow, Howard N.

    2015-02-07

    Self-contained fire extinguishers are a robust, reliable and minimally invasive means of fire suppression for gloveboxes. Plutonium gloveboxes are known to present harsh environmental conditions for polymer materials, these include radiation damage and chemical exposure, both of which tend to degrade the lifetime of engineered polymer components. The primary component of interest in self-contained fire extinguishers is the nylon 6-6 machined tube that comprises the main body of the system.Thermo-mechanical modeling and characterization of nylon 6-6 for use in plutonium glovebox applications has been carried out. Data has been generated regarding property degradation leading to poor, or reduced, engineering performancemore » of nylon 6-6 components. In this study, nylon 6-6 tensile specimens conforming to the casing of self-contained fire extinguisher systems have been exposed to hydrochloric, nitric, and sulfuric acids. This information was used to predict the performance of a load bearing engineering component comprised of nylon 6-6 and designed to operate in a consistent manner over a specified time period. The study provides a fundamental understanding of the engineering performance of the fire suppression system and the effects of environmental degradation due to acid exposure on engineering performance. Data generated help identify the limitations of self-contained fire extinguishers. No critical areas of concern for plutonium glovebox applications of nylon 6-6 have been identified when considering exposure to mineral acid.« less

  15. Reliability study of an emerging fire suppression system

    SciTech Connect (OSTI)

    Miller, David A.; Rossati, Lyric M.; Fritz, Nathan K.; Cournoyer, Michael E.; Granzow, Howard N.

    2015-02-07

    Self-contained fire extinguishers are a robust, reliable and minimally invasive means of fire suppression for gloveboxes. Plutonium gloveboxes are known to present harsh environmental conditions for polymer materials, these include radiation damage and chemical exposure, both of which tend to degrade the lifetime of engineered polymer components. The primary component of interest in self-contained fire extinguishers is the nylon 6-6 machined tube that comprises the main body of the system.Thermo-mechanical modeling and characterization of nylon 6-6 for use in plutonium glovebox applications has been carried out. Data has been generated regarding property degradation leading to poor, or reduced, engineering performance of nylon 6-6 components. In this study, nylon 6-6 tensile specimens conforming to the casing of self-contained fire extinguisher systems have been exposed to hydrochloric, nitric, and sulfuric acids. This information was used to predict the performance of a load bearing engineering component comprised of nylon 6-6 and designed to operate in a consistent manner over a specified time period. The study provides a fundamental understanding of the engineering performance of the fire suppression system and the effects of environmental degradation due to acid exposure on engineering performance. Data generated help identify the limitations of self-contained fire extinguishers. No critical areas of concern for plutonium glovebox applications of nylon 6-6 have been identified when considering exposure to mineral acid.

  16. Pressure suppression containment system for boiling water reactor

    DOE Patents [OSTI]

    Gluntz, Douglas M.; Nesbitt, Loyd B.

    1997-01-01

    A system for suppressing the pressure inside the containment of a BWR following a postulated accident. A piping subsystem is provided which features a main process pipe that communicates the wetwell airspace to a connection point downstream of the guard charcoal bed in an offgas system and upstream of the main bank of delay charcoal beds which give extensive holdup to offgases. The main process pipe is fitted with both inboard and outboard containment isolation valves. Also incorporated in the main process pipe is a low-differential-pressure rupture disk which prevents any gas outflow in this piping whatsoever until or unless rupture occurs by virtue of pressure inside this main process pipe on the wetwell airspace side of the disk exceeding the design opening (rupture) pressure differential. The charcoal holds up the radioactive species in the noncondensable gas from the wetwell plenum by adsorption, allowing time for radioactive decay before the gas is vented to the environs.

  17. Pressure suppression containment system for boiling water reactor

    DOE Patents [OSTI]

    Gluntz, D.M.; Nesbitt, L.B.

    1997-01-21

    A system is disclosed for suppressing the pressure inside the containment of a BWR following a postulated accident. A piping subsystem is provided which features a main process pipe that communicates the wetwell airspace to a connection point downstream of the guard charcoal bed in an offgas system and upstream of the main bank of delay charcoal beds which give extensive holdup to offgases. The main process pipe is fitted with both inboard and outboard containment isolation valves. Also incorporated in the main process pipe is a low-differential-pressure rupture disk which prevents any gas outflow in this piping whatsoever until or unless rupture occurs by virtue of pressure inside this main process pipe on the wetwell airspace side of the disk exceeding the design opening (rupture) pressure differential. The charcoal holds up the radioactive species in the noncondensable gas from the wetwell plenum by adsorption, allowing time for radioactive decay before the gas is vented to the environs. 3 figs.

  18. A nondestructive test for aircraft Halon bottles, the development of an acoustic emission application

    SciTech Connect (OSTI)

    Beattie, A.G.

    1996-12-01

    An acoustic emission test for aircraft Halon bottles has been developed in response to a need expressed by the US Airline Industry. During this development many choices had to be made about test methods, procedures and analysis techniques. This paper discusses these choices and how successful they were. The test itself was designed to replace the currently required hydrostatic test for these bottles. The necessary load is applied by heating the sealed bottles. Acoustic emission is monitored, during the heating, by six sensors held in position by a special fixture. A prototype of the test apparatus was constructed and used in two commercial Halon bottle repair and test facilities. Results to date indicate that about 97% of the bottles tested show no indications of flaws. The other 3% have had indications of possible flaws in non-critical areas of the bottles. All bottles tested to date have passed the hydrostatic test subsequent to the acoustic emission test.

  19. Active Suppression of Drilling System Vibrations For Deep Drilling

    SciTech Connect (OSTI)

    Raymond, David W.; Blankenship, Douglas A.; Buerger, Stephen; Mesh, Mikhail; Radigan, William Thomas; Su, Jiann-Cherng

    2015-10-01

    The dynamic stability of deep drillstrings is challenged by an inability to impart controllability with ever-changing conditions introduced by geology, depth, structural dynamic properties and operating conditions. A multi-organizational LDRD project team at Sandia National Laboratories successfully demonstrated advanced technologies for mitigating drillstring vibrations to improve the reliability of drilling systems used for construction of deep, high-value wells. Using computational modeling and dynamic substructuring techniques, the benefit of controllable actuators at discrete locations in the drillstring is determined. Prototype downhole tools were developed and evaluated in laboratory test fixtures simulating the structural dynamic response of a deep drillstring. A laboratory-based drilling applicability demonstration was conducted to demonstrate the benefit available from deployment of an autonomous, downhole tool with self-actuation capabilities in response to the dynamic response of the host drillstring. A concept is presented for a prototype drilling tool based upon the technical advances. The technology described herein is the subject of U.S. Patent Application No. 62219481, entitled "DRILLING SYSTEM VIBRATION SUPPRESSION SYSTEMS AND METHODS", filed September 16, 2015.

  20. Method and system for modulation of gain suppression in high average power laser systems

    DOE Patents [OSTI]

    Bayramian, Andrew James

    2012-07-31

    A high average power laser system with modulated gain suppression includes an input aperture associated with a first laser beam extraction path and an output aperture associated with the first laser beam extraction path. The system also includes a pinhole creation laser having an optical output directed along a pinhole creation path and an absorbing material positioned along both the first laser beam extraction path and the pinhole creation path. The system further includes a mechanism operable to translate the absorbing material in a direction crossing the first laser beam extraction laser path and a controller operable to modulate the second laser beam.

  1. Verification study of an emerging fire suppression system

    SciTech Connect (OSTI)

    Cournoyer, Michael E.; Waked, R. Ryan; Granzow, Howard N.; Gubernatis, David C.

    2016-01-01

    Self-contained fire extinguishers are a robust, reliable and minimally invasive means of fire suppression for gloveboxes. Moreover, plutonium gloveboxes present harsh environmental conditions for polymer materials; these include radiation damage and chemical exposure, both of which tend to degrade the lifetime of engineered polymer components. Several studies have been conducted to determine the robustness of selfcontained fire extinguishers in plutonium gloveboxes in a nuclear facility, verification tests must be performed. These tests include activation and mass loss calorimeter tests. In addition, compatibility issues with chemical components of the self-contained fire extinguishers need to be addressed. Our study presents activation and mass loss calorimeter test results. After extensive studies, no critical areas of concern have been identified for the plutonium glovebox application of Fire Foe™, except for glovebox operations that use large quantities of bulk plutonium or uranium metal such as metal casting and pyro-chemistry operations.

  2. Optimized pulse sequences for suppressing unwanted transitions in quantum systems

    SciTech Connect (OSTI)

    Schroeder, C. A.; Agarwal, G. S.

    2011-01-15

    We investigate the nature of the pulse sequence so that unwanted transitions in quantum systems can be inhibited optimally. For this purpose we show that the sequence of pulses proposed by Uhrig [Phys. Rev. Lett. 98, 100504 (2007)] in the context of inhibition of environmental dephasing effects is optimal. We derive exact results for inhibiting the transitions and confirm the results numerically. We posit a very significant improvement by usage of the Uhrig sequence over an equidistant sequence in decoupling a quantum system from unwanted transitions. The physics of inhibition is the destructive interference between transition amplitudes before and after each pulse.

  3. Methods And System Suppressing Clutter In A Gain-Block, Radar-Responsive Tag System

    DOE Patents [OSTI]

    Ormesher, Richard C.; Axline, Robert M.

    2006-04-18

    Methods and systems reduce clutter interference in a radar-responsive tag system. A radar transmits a series of linear-frequency-modulated pulses and receives echo pulses from nearby terrain and from radar-responsive tags that may be in the imaged scene. Tags in the vicinity of the radar are activated by the radar's pulses. The tags receive and remodulate the radar pulses. Tag processing reverses the direction, in time, of the received waveform's linear frequency modulation. The tag retransmits the remodulated pulses. The radar uses a reversed-chirp de-ramp pulse to process the tag's echo. The invention applies to radar systems compatible with coherent gain-block tags. The invention provides a marked reduction in the strength of residual clutter echoes on each and every echo pulse received by the radar. SAR receiver processing effectively whitens passive-clutter signatures across the range dimension. Clutter suppression of approximately 14 dB is achievable for a typical radar system.

  4. PPPL extends system for suppressing instabilities to long-pulse experiments

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    on KSTAR | Princeton Plasma Physics Lab PPPL extends system for suppressing instabilities to long-pulse experiments on KSTAR By John Greenwald March 18, 2014 Tweet Widget Google Plus One Share on Facebook A look into the microwave launcher showing the steering mirrors that guide the beam into the plasma. (Photo by PPPL) A look into the microwave launcher showing the steering mirrors that guide the beam into the plasma. PPPL collaborations have been instrumental in developing a system to

  5. PPPL extends system for suppressing instabilities to long-pulse experiments

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    on KSTAR | Princeton Plasma Physics Lab PPPL extends system for suppressing instabilities to long-pulse experiments on KSTAR By John Greenwald March 19, 2014 Tweet Widget Google Plus One Share on Facebook A look into the microwave launcher showing the steering mirrors that guide the beam into the plasma. (Photo by PPPL) A look into the microwave launcher showing the steering mirrors that guide the beam into the plasma. PPPL collaborations have been instrumental in developing a system to

  6. System and method that suppresses intensity fluctuations for free space high-speed optical communication

    DOE Patents [OSTI]

    Berman, Gennady P.; Bishop, Alan R.; Nguyen, Dinh C.; Chernobrod, Boris M.; Gorshkov, Vacheslav N.

    2009-10-13

    A high-speed (Gbps), free space optical communication system is based on spectral encoding of radiation from a wide band light source, such as a laser. By using partially coherent laser beams in combination with a relatively slow photosensor, scintillations can be suppressed by orders of magnitude for distances of more than 10 km. To suppress the intensity fluctuations due to atmospheric turbulence, a source with partial transverse coherence in combination with slow response time photodetector is used. Information is encoded in the spectral domain of a wideband optical source by modulation of spectral amplitudes. A non-coherent light source with wide spectrum (an LED, for example) may be used for high-speed communication over short (less than about a mile) distances.

  7. NO.sub.x catalyst and method of suppressing sulfate formation in an exhaust purification system

    DOE Patents [OSTI]

    Balmer-Millar, Mari Lou; Park, Paul W.; Panov, Alexander G.

    2007-06-26

    The activity and durability of a zeolite lean-burn NOx catalyst can be increased by loading metal cations on the outer surface of the zeolite. However, the metal loadings can also oxidize sulfur dioxide to cause sulfate formation in the exhaust. The present invention is a method of suppressing sulfate formation in an exhaust purification system including a NO.sub.x catalyst. The NO.sub.x catalyst includes a zeolite loaded with at least one metal. The metal is selected from among an alkali metal, an alkaline earth metal, a lanthanide metal, a noble metal, and a transition metal. In order to suppress sulfate formation, at least a portion of the loaded metal is complexed with at least one of sulfate, phosphate, and carbonate.

  8. NO.sub.x catalyst and method of suppressing sulfate formation in an exhaust purification system

    DOE Patents [OSTI]

    Balmer-Millar, Mari Lou; Park, Paul W.; Panov, Alexander G.

    2006-08-22

    The activity and durability of a zeolite lean-bum NOx catalyst can be increased by loading metal cations on the outer surface of the zeolite. However, the metal loadings can also oxidize sulfur dioxide to cause sulfate formation in the exhaust. The present invention is a method of suppressing sulfate formation in an exhaust purification system including a NO.sub.x catalyst. The NO.sub.x catalyst includes a zeolite loaded with at least one metal. The metal is selected from among an alkali metal, an alkaline earth metal, a lanthanide metal, a noble metal, and a transition metal. In order to suppress sulfate formation, at least a portion of the loaded metal is complexed with at least one of sulfate, phosphate, and carbonate.

  9. Proposed methodology for combustion toxicology testing of combined halon replacement agent/jet fuel interaction. Final report, June-September 1991

    SciTech Connect (OSTI)

    Kibert, C.J.

    1993-04-01

    An international consensus to remove Chlorofluorocarbon (CFC) compounds from production and U.S. national policy to implement the resulting protocols has motivated the U.S. Air Force to embark on a program to find a suitable replacement for Halon 1211, currently used to extinguish flight line fires. This research addressed the feasibility of conducting a combustion toxicology (CT) program to assess the toxic products of the combustion interaction of JP-8 and the Group 1 or so-called Near Term candidate replacement agents for Halon 1211: HCFCs -123, -124, and -142b. A laboratory scale experiment benchmarked on large scale testing of a 150 sq ft pool fire was developed on the basis of Froude scaling of the full scale fire to a 15 x 15 cm pan fire. A prototype apparatus was developed and investigation into the use of animal behavior methods as an indicator of human incapacitation was conducted. The result is a new method which may potentially be utilized for future toxicity studies of the combustion interaction of current and future U.S. Air Force fuels with various fire extinguishants. Extinguishing agents, Halon 1211, Halon replacement, Combustion.

  10. Disordered crystal structure of 20H-AlON, Al{sub 10}O{sub 3}N{sub 8}

    SciTech Connect (OSTI)

    Banno, Hiroki; Funahashi, Shiro; Asaka, Toru; Hirosaki, Naoto; Fukuda, Koichiro

    2015-10-15

    The disordered crystal structure of 20H-AlON (Al{sub 10}O{sub 3}N{sub 8}) was determined by combined use of X-ray powder diffraction and transmission electron microscopy. The title compound is hexagonal with space group P6{sub 3}/mmc (Z=2) and the unit-cell dimensions are a=0.307082(5) nm, c=5.29447(8) nm and V=0.432376(12) nm{sup 3}. The structural model showed the positional disordering of three of the six Al sites in the unit cell. The reliability indices calculated from the Rietveld method were R{sub wp}=6.97%, S (=R{sub wp}/R{sub e})=1.68, R{sub p}=5.45%, R{sub B}=5.13% and R{sub F}=4.56%. We interpreted the disordered structure of 20H-AlON as a statistical average of six different types of ordered structural configurations, which are composed of an octahedral [Al(O, N){sub 6}] layer and tetrahedral [Al(O, N){sub 4}] layers. We demonstrated the high correlations between the hexagonal unit-cell dimensions and the octahedral layer concentrations for AlON and SiAlON polytypoids. - Graphical abstract: Variations of a and c/(n{sub O}+n{sub T}) with n{sub O}/(n{sub O}+n{sub T}). The a and c are the hexagonal unit-cell dimensions of AlON, SiAlON and AlN. The n{sub O} and n{sub T} are, respectively, the numbers of octahedral and tetrahedral layers in the unit cells. The unit-cell dimensions in literature are plotted in black plus for AlON and black cross for SiAlON. The unit-cell dimensions of AlN are a=0.3110 nm and c=0.4980 nm. - Highlights: • Crystal structure of Al10O3N8 is determined by laboratory X-ray powder diffraction. • The atom arrangements are represented by the split-atom model. • Six types of ordered atom arrangements are derived from the disordered structure. • Hexagonal unit-cell dimensions changed systematically for AlON and SiAlON compounds.

  11. Computational fluid dynamics simulation of the air/suppressant flow in an uncluttered F18 engine nacelle

    SciTech Connect (OSTI)

    Lopez, A.R.; Gritzo, L.A.; Hassan, B.

    1997-06-01

    For the purposes of designing improved Halon-alternative fire suppression strategies for aircraft applications, Computational Fluid Dynamics (CFD) simulations of the air flow, suppressant transport, and air-suppressant mixing within an uncluttered F18 engine nacelle were performed. The release of inert gases from a Solid Propellant Gas Generator (SPGG) was analyzed at two different injection locations in order to understand the effect of injection position on the flow patterns and the mixing of air and suppression agent. An uncluttered engine nacelle was simulated to provide insight into the global flow features as well as to promote comparisons with previous nacelle fire tests and recent water tunnel tests which included little or no clutter. Oxygen concentration levels, fuel/air residence times that would exist if a small fuel leak were present, velocity contours, and streamline patterns are presented inside the engine nacelle. The numerical results show the influence of the gent release location on regions of potential flame extinction due to oxygen inerting and high flame strain. The occurrence of inflow through the exhaust ducts on the aft end of the nacelle is also predicted. As expected, the predicted oxygen concentration levels were consistently higher than the measured levels since a fire was not modeled in this analysis. Despite differences in the conditions of these simulations and the experiments, good agreement was obtained between the CFD predictions and the experimental measurements.

  12. Methods and apparatus of suppressing tube waves within a bore hole and seismic surveying systems incorporating same

    DOE Patents [OSTI]

    West, Phillip B.; Haefner, Daryl

    2004-08-17

    Methods and apparatus for attenuating waves in a bore hole, and seismic surveying systems incorporating the same. In one embodiment, an attenuating device includes a soft compliant bladder coupled to a pressurized gas source. A pressure regulating system reduces the pressure of the gas from the gas source prior to entering the bladder and operates in conjunction with the hydrostatic pressure of the fluid in a bore hole to maintain the pressure of the bladder at a specified pressure relative to the surrounding bore hole pressure. Once the hydrostatic pressure of the bore hole fluid exceeds that of the gas source, bore hole fluid may be admitted into a vessel of the gas source to further compress and displace the gas contained therein. In another embodiment, a water-reactive material may be used to provide gas to the bladder wherein the amount of gas generated by the water-reactive material may depend on the hydrostatic pressure of the bore hole fluid.

  13. Methods and apparatus of suppressing tube waves within a bore hole and seismic surveying systems incorporating same

    DOE Patents [OSTI]

    West, Phillip B.; Haefner, Daryl

    2005-12-13

    Methods and apparatus for attenuating waves in a bore hole, and seismic surveying systems incorporating the same. In one embodiment, an attenuating device includes a soft compliant bladder coupled to a pressurized gas source. A pressure regulating system reduces the pressure of the gas from the gas source prior to entering the bladder and operates in conjunction with the hydrostatic pressure of the fluid in a bore hole to maintain the pressure of the bladder at a specified pressure relative to the surrounding bore hole pressure. Once the hydrostatic pressure of the bore hole fluid exceeds that of the gas source, bore hole fluid may be admitted into a vessel of the gas source to further compress and displace the gas contained therein. In another embodiment, a water-reactive material may be used to provide gas to the bladder wherein the amount of gas generated by the water-reactive material may depend on the hydrostatic pressure of the bore hole fluid.

  14. SU-E-J-243: Possibility of Exposure Dose Reduction of Cone-Beam Computed Tomography in An Image Guided Patient Positioning System by Using Various Noise Suppression Filters

    SciTech Connect (OSTI)

    Kamezawa, H; Arimura, H; Ohki, M; Shirieda, K; Kameda, N

    2014-06-01

    Purpose: To investigate the possibility of exposure dose reduction of the cone-beam computed tomography (CBCT) in an image guided patient positioning system by using 6 noise suppression filters. Methods: First, a reference dose (RD) and low-dose (LD)-CBCT (X-ray volume imaging system, Elekta Co.) images were acquired with a reference dose of 86.2 mGy (weighted CT dose index: CTDIw) and various low doses of 1.4 to 43.1 mGy, respectively. Second, an automated rigid registration for three axes was performed for estimating setup errors between a planning CT image and the LD-CBCT images, which were processed by 6 noise suppression filters, i.e., averaging filter (AF), median filter (MF), Gaussian filter (GF), bilateral filter (BF), edge preserving smoothing filter (EPF) and adaptive partial median filter (AMF). Third, residual errors representing the patient positioning accuracy were calculated as an Euclidean distance between the setup error vectors estimated using the LD-CBCT image and RD-CBCT image. Finally, the relationships between the residual error and CTDIw were obtained for 6 noise suppression filters, and then the CTDIw for LD-CBCT images processed by the noise suppression filters were measured at the same residual error, which was obtained with the RD-CBCT. This approach was applied to an anthropomorphic pelvic phantom and two cancer patients. Results: For the phantom, the exposure dose could be reduced from 61% (GF) to 78% (AMF) by applying the noise suppression filters to the CBCT images. The exposure dose in a prostate cancer case could be reduced from 8% (AF) to 61% (AMF), and the exposure dose in a lung cancer case could be reduced from 9% (AF) to 37% (AMF). Conclusion: Using noise suppression filters, particularly an adaptive partial median filter, could be feasible to decrease the additional exposure dose to patients in image guided patient positioning systems.

  15. Benchmark enclosure fire suppression experiments - phase 1 test report.

    SciTech Connect (OSTI)

    Figueroa, Victor G.; Nichols, Robert Thomas; Blanchat, Thomas K.

    2007-06-01

    A series of fire benchmark water suppression tests were performed that may provide guidance for dispersal systems for the protection of high value assets. The test results provide boundary and temporal data necessary for water spray suppression model development and validation. A review of fire suppression in presented for both gaseous suppression and water mist fire suppression. The experimental setup and procedure for gathering water suppression performance data are shown. Characteristics of the nozzles used in the testing are presented. Results of the experiments are discussed.

  16. Mode locking and island suppression by resonant magnetic perturbations in

    Office of Scientific and Technical Information (OSTI)

    Rutherford regime (Journal Article) | SciTech Connect Mode locking and island suppression by resonant magnetic perturbations in Rutherford regime Citation Details In-Document Search Title: Mode locking and island suppression by resonant magnetic perturbations in Rutherford regime We demonstrate in theory that tearing mode locking and magnetic island suppression by resonant magnetic perturbations (RMPs) can correspond to different states of a same dynamic system governed by the torque balance

  17. ZERO SUPPRESSION FOR RECORDERS

    DOE Patents [OSTI]

    Fort, W.G.S.

    1958-12-30

    A zero-suppression circuit for self-balancing recorder instruments is presented. The essential elements of the circuit include a converter-amplifier having two inputs, one for a reference voltage and the other for the signal voltage under analysis, and a servomotor with two control windings, one coupled to the a-c output of the converter-amplifier and the other receiving a reference input. Each input circuit to the converter-amplifier has a variable potentiometer and the sliders of the potentiometer are ganged together for movement by the servoinotor. The particular noveity of the circuit resides in the selection of resistance values for the potentiometer and a resistor in series with the potentiometer of the signal circuit to ensure the full value of signal voltage variation is impressed on a recorder mechanism driven by servomotor.

  18. Suppressed Charmed B Decay

    SciTech Connect (OSTI)

    Snoek, Hella Leonie; /Vrije U., Amsterdam

    2011-11-28

    This thesis describes the measurement of the branching fractions of the suppressed charmed B{sup 0} {yields} D{sup (*)-} a{sub 0}{sup +} decays and the non-resonant B{sup 0} {yields} D{sup (*)-} {eta}{pi}{sup +} decays in approximately 230 million {Upsilon}(4S) {yields} B{bar B} events. The data have been collected with the BABAR detector at the PEP-II B factory at the Stanford Linear Accelerator Center in California. Theoretical predictions of the branching fraction of the B{sup 0} {yields} D{sup (*)-} a{sub 0}{sup +} decays show large QCD model dependent uncertainties. Non-factorizing terms, in the naive factorization model, that can be calculated by QCD factorizing models have a large impact on the branching fraction of these decay modes. The predictions of the branching fractions are of the order of 10{sup -6}. The measurement of the branching fraction gives more insight into the theoretical models. In general a better understanding of QCD models will be necessary to conduct weak interaction physics at the next level. The presence of CP violation in electroweak interactions allows the differentiation between matter and antimatter in the laws of physics. In the Standard Model, CP violation is incorporated in the CKM matrix that describes the weak interaction between quarks. Relations amongst the CKM matrix elements are used to present the two relevant parameters as the apex of a triangle (Unitarity Triangle) in a complex plane. The over-constraining of the CKM triangle by experimental measurements is an important test of the Standard Model. At this moment no stringent direct measurements of the CKM angle {gamma}, one of the interior angles of the Unitarity Triangle, are available. The measurement of the angle {gamma} can be performed using the decays of neutral B mesons. The B{sup 0} {yields} D{sup (*)-} a{sub 0}{sup +} decay is sensitive to the angle {gamma} and, in comparison to the current decays that are being employed, could significantly enhance the measurement of this angle. However, the low expected branching fraction for the B{sup 0} {yields} D{sup (*)-} a{sub 0}{sup +} decay channels could severely impact the measurement. A prerequisite of the measurement of the CKM angle is the observation of the B{sup 0} {yields} D{sup (*)-} a{sub 0}{sup +} decay on which this thesis reports. The BABAR experiment consists of the BABAR detector and the PEP-II e{sup +}e{sup -} collider. The design of the experiment has been optimized for the study of CP violation in the decays of neutral B mesons but is also highly suitable for the search for rare B decays such as the B{sup 0} {yields} D{sup (*)-} a{sub 0}{sup +} decay. The PEP-II collider operates at the {Upsilon}(4S) resonance and is a clean source of B{bar B} meson pairs.

  19. DOE-STD-1166-2003; Deactivation and Decommissioning Functional...

    Energy Savers [EERE]

    ... alarms, plant air, steam, inerting gases, oxygen and other gases, potable water, fire suppression (water, CO2, Halon, etc.), steam, sewage, stormwater, and groundwater drains. b. ...

  20. SAR ambiguous range suppression.

    SciTech Connect (OSTI)

    Doerry, Armin Walter

    2006-09-01

    Pulsed Radar systems suffer range ambiguities, that is, echoes from pulses transmitted at different times arrive at the receiver simultaneously. Conventional mitigation techniques are not always adequate. However, pulse modulation schemes exist that allow separation of ambiguous ranges in Doppler space, allowing easy filtering of problematic ambiguous ranges.

  1. Kink instability suppression with stochastic cooling pickup and kicker

    SciTech Connect (OSTI)

    Hao Y.; Blaskiewicz, M.; Litvinenko, V.N.; Ptitsyn, V.

    2012-05-20

    The kink instability is one of the major beam dynamics issues of the linac-ring based electron ion collider. This head-tail type instability arises from the oscillation of the electron beam inside the opposing ion beam. It must be suppressed to achieve the desired luminosity. There are various ways to suppress the instability, such as tuning the chromaticity in the ion ring or by a dedicated feedback system of the electron beam position at IP, etc. However, each method has its own limitation. In this paper, we will discuss an alternative opportunity of suppressing the kink instability of the proposed eRHIC at BNL using the existing pickup-kicker system of the stochastic cooling system in RHIC.

  2. Passive runaway electron suppression in tokamak disruptions

    SciTech Connect (OSTI)

    Smith, H. M.; Helander, P.

    2013-07-15

    Runaway electrons created in disruptions pose a serious problem for tokamaks with large current. It would be desirable to have a runaway electron suppression method which is passive, i.e., a method that does not rely on an uncertain disruption prediction system. One option is to let the large electric field inherent in the disruption drive helical currents in the wall. This would create ergodic regions in the plasma and increase the runaway losses. Whether these regions appear at a suitable time and place to affect the formation of the runaway beam depends on disruption parameters, such as electron temperature and density. We find that it is difficult to ergodize the central plasma before a beam of runaway current has formed. However, the ergodic outer region will make the Ohmic current profile contract, which can lead to instabilities that yield large runaway electron losses.

  3. MEK5 suppresses osteoblastic differentiation (Journal Article...

    Office of Scientific and Technical Information (OSTI)

    SciTech Connect Search Results Journal Article: MEK5 suppresses osteoblastic ... OSTI Identifier: 22462118 Resource Type: Journal Article Resource Relation: Journal Name: ...

  4. Ferromagnetic resonance probe liftoff suppression apparatus

    DOE Patents [OSTI]

    Davis, Thomas J.; Tomeraasen, Paul L.

    1985-01-01

    A liftoff suppression apparatus utilizing a liftoff sensing coil to sense the amount a ferromagnetic resonance probe lifts off the test surface during flaw detection and utilizing the liftoff signal to modulate the probe's field modulating coil to suppress the liftoff effects.

  5. METHOD OF SUPPRESSING GASTROINTESTINAL UREASE ACTIVITY

    DOE Patents [OSTI]

    Visek, W.J.

    1963-04-23

    This patent shows a method of increasing the growth rate of chicks. Certain diacyl substituted ureas such as alloxan, murexide, and barbituric acid are added to their feed, thereby suppressing gastrointestinal urease activity and thus promoting growth. (AEC)

  6. Suppression of Grain Boundaries in Graphene Growth on Superstructured...

    Office of Scientific and Technical Information (OSTI)

    Suppression of Grain Boundaries in Graphene Growth on Superstructured Mn-Cu(111) Surface Title: Suppression of Grain Boundaries in Graphene Growth on Superstructured Mn-Cu(111) ...

  7. Suppression of x-rays generated by runaway electrons in ATF

    SciTech Connect (OSTI)

    Rasmussen, D.A.; England, A.C.; Eberle, C.C.; Devan, W.R.; Harris, J.H.; Jernigan, T.C.; Kindsfather, R.R.; Morris, R.N.; Murakami, M.; Neilson, G.H.

    1987-01-01

    X-ray emission from runaway electrons on ATF is a serious issue. Runaway suppression techniques used on Heliotron-E are not adequate for ATF. Three approaches have been developed to suppress runaway production. Monitoring devices have been installed in occupied areas and personnel access and exposure will be limited. Additional shielding will be added as required. These systems will be ready for installation and testing on ATF prior to commissioning or first plasma operation.

  8. Suppression of phosphate liberation from eutrophic lake sediment by using fly ash and ordinary Portland cement

    SciTech Connect (OSTI)

    Heng-Peng Ye; Fan-Zhong Chen; Yan-Qing Sheng; Guo-Ying Sheng; Jia-Mo Fu

    2006-08-15

    In this study, the effect of suppression on phosphate liberation from eutrophic lake sediment by using fly ash and ordinary Portland cement (OPC) was investigated by small scale experiment. A system including sediment, lake water, and several kinds of capping materials was designed to clarify the suppression of phosphate liberation from sediment under the anaerobic condition. The suppression efficiencies of fly ash, OPC and glass bead used as control material were also determined, and these effects were discussed. The suppression efficiency of glass bead was 44.4%, and those of fly ash and OPC were 84.4%, 94.9%, respectively. The suppression by fly ash and OPC was mainly carried out by the adsorption effect, in addition to the covering effect. The suppression efficiency depended on the amounts of the material used, and about 90% of liberated phosphate was suppressed by fly ash of 10.0 Kg m{sup -2}, and OPC of 6.0 Kg m{sup -2}. The concentrations of heavy metals, such as mercury, cadmium, lead, copper, zinc, chromium, silver, arsenic and nickel, in fly ash and OPC were lower than those in the environmental materials. And it was considered that the concentrations of heavy metals in fly ash and OPC were too low to influence the ecosystem in natural water region.

  9. Traveling-wave device with mass flux suppression (Patent) | DOEPatents

    Office of Scientific and Technical Information (OSTI)

    Traveling-wave device with mass flux suppression Title: Traveling-wave device with mass flux suppression A traveling-wave device is provided with the conventional moving pistons ...

  10. Stratospheric ozone protection: The Montreal Protocol and Title VI of the Clean Air Act Amendments of 1990

    SciTech Connect (OSTI)

    Babst, C.R. III

    1993-08-01

    The stratospheric ozone layer protects the surface of the Earth from harmful ultraviolet (UV-B) radiation, which has been causally linked to skin cancer and cataracts, suppression of the human immune system, damage to crops and aquatic organisms, the formation of ground-level zone and the rapid weathering of outdoor plastics. In recent years, scientists have observed a significant deterioration of the ozone layer, particularly over the poles, but increasingly over populated regions as well. This deterioration has been attributed to the atmospheric release of certain man-made halocarbons, including chlorofluorocarbons (CFCs), halons, methyl chloroform and carbon tetrachloride. Once used extensively as propellants for aerosol sprays (but generally banned for such purposes since 1978), CFCs are widely used today as refrigerants, foams and solvents. All of these chlorinated (CFC, methyl chloroform and carbon tetrachloride) and brominated (halon) compounds are classified for regulatory purposes as Class I substances because of their significant ozone-depleting potential. Hydrochlorofluorocarbons (HCFCs), developed as alternatives to CFCs and halons for many different applications, have been classified for regulatory purposes as Class II substances because of their relatively less destructive impact on stratospheric ozone. This paper describes the following regulations to reduce destruction of the ozone layer: the Montreal Protocol; Title VI of the Clean air Act Amendments of 1990; Accelerated Phase-out schedules developed by the countries which signed the Montreal Protocol; Use restrictions; Recycling and Emission reduction requirements; Servicing of motor vehicle air conditions; ban on nonessential products; labeling requirements; safe alternatives. 6 refs.

  11. SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE GENERATOR SETS...

    Office of Scientific and Technical Information (OSTI)

    POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; ENGINES; NOISE POLLUTION ABATEMENT; POLLUTION CONTROL EQUIPMENT; ELECTRIC GENERATORS No abstract prepared....

  12. PPPL extends system for suppressing instabilities to long-pulse...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    San Diego and on the Korea Superconducting Tokamak Advanced Research (KSTAR) facility in South Korea - and now is revising the KSTAR design to operate during extended plasma...

  13. Pulse compression and prepulse suppression apparatus

    DOE Patents [OSTI]

    Dane, Clifford B.; Hackel, Lloyd A.; George, Edward V.; Miller, John L.; Krupke, William F.

    1993-01-01

    A pulse compression and prepulse suppression apparatus (10) for time compressing the output of a laser (14). A pump pulse (46) is separated from a seed pulse (48) by a first polarized beam splitter (20) according to the orientation of a half wave plate (18). The seed pulse (48) is directed into an SBS oscillator (44) by two plane mirrors (22, 26) and a corner mirror (24), the corner mirror (24) being movable to adjust timing. The pump pulse (46) is directed into an SBS amplifier 34 wherein SBS occurs. The seed pulse (48), having been propagated from the SBS oscillator (44), is then directed through the SBS amplifier (34) wherein it sweeps the energy of the pump pulse (46) out of the SBS amplifier (34) and is simultaneously compressed, and the time compressed pump pulse (46) is emitted as a pulse output (52). A second polarized beam splitter (38) directs any undepleted pump pulse 58 away from the SBS oscillator (44).

  14. Pulse compression and prepulse suppression apparatus

    DOE Patents [OSTI]

    Dane, C.B.; Hackel, L.A.; George, E.V.; Miller, J.L.; Krupke, W.F.

    1993-11-09

    A pulse compression and prepulse suppression apparatus (10) for time compressing the output of a laser (14). A pump pulse (46) is separated from a seed pulse (48) by a first polarized beam splitter (20) according to the orientation of a half wave plate (18). The seed pulse (48) is directed into an SBS oscillator (44) by two plane mirrors (22, 26) and a corner mirror (24), the corner mirror (24) being movable to adjust timing. The pump pulse (46) is directed into an SBS amplifier 34 wherein SBS occurs. The seed pulse (48), having been propagated from the SBS oscillator (44), is then directed through the SBS amplifier (34) wherein it sweeps the energy of the pump pulse (46) out of the SBS amplifier (34) and is simultaneously compressed, and the time compressed pump pulse (46) is emitted as a pulse output (52). A second polarized beam splitter (38) directs any undepleted pump pulse 58 away from the SBS oscillator (44).

  15. SUPPRESSION OF STAR FORMATION IN NGC 1266

    SciTech Connect (OSTI)

    Alatalo, Katherine; Lanz, Lauranne; Bitsakis, Theodoros; Appleton, Philip N.; Ogle, Patrick M.; Lacy, Mark; Lonsdale, Carol J.; Nyland, Kristina; Meier, David S.; Cales, Sabrina L.; Chang, Philip; Davis, Timothy A.; De Zeeuw, P. T.; Martn, Sergio

    2015-01-01

    NGC 1266 is a nearby lenticular galaxy that harbors a massive outflow of molecular gas powered by the mechanical energy of an active galactic nucleus (AGN). It has been speculated that such outflows hinder star formation (SF) in their host galaxies, providing a form of feedback to the process of galaxy formation. Previous studies, however, indicated that only jets from extremely rare, high-power quasars or radio galaxies could impart significant feedback on their hosts. Here we present detailed observations of the gas and dust continuum of NGC 1266 at millimeter wavelengths. Our observations show that molecular gas is being driven out of the nuclear region at M-dot {sub out}?110 M{sub ?} yr{sup 1}, of which the vast majority cannot escape the nucleus. Only 2 M {sub ?} yr{sup 1} is actually capable of escaping the galaxy. Most of the molecular gas that remains is very inefficient at forming stars. The far-infrared emission is dominated by an ultra-compact (? 50 pc) source that could either be powered by an AGN or by an ultra-compact starburst. The ratio of the SF surface density (?{sub SFR}) to the gas surface density (?{sub H{sub 2}}) indicates that SF is suppressed by a factor of ?50 compared to normal star-forming galaxies if all gas is forming stars, and ?150 for the outskirt (98%) dense molecular gas if the central region is powered by an ultra-compact starburst. The AGN-driven bulk outflow could account for this extreme suppression by hindering the fragmentation and gravitational collapse necessary to form stars through a process of turbulent injection. This result suggests that even relatively common, low-power AGNs are able to alter the evolution of their host galaxies as their black holes grow onto the M-? relation.

  16. Methods for suppressing isomerization of olefin metathesis products

    DOE Patents [OSTI]

    Firth, Bruce E.; Kirk, Sharon E.; Gavaskar, Vasudeo S.

    2015-09-22

    A method for suppressing isomerization of an olefin metathesis product produced in a metathesis reaction includes adding an isomerization suppression agent to a mixture that includes the olefin metathesis product and residual metathesis catalyst from the metathesis reaction under conditions that are sufficient to passivate at least a portion of the residual metathesis catalyst. The isomerization suppression agent is phosphorous acid, a phosphorous acid ester, phosphinic acid, a phosphinic acid ester or combinations thereof. Methods of refining natural oils are described.

  17. A spray-suppression model for turbulent combustion

    SciTech Connect (OSTI)

    DESJARDIN,PAUL E.; TIESZEN,SHELDON R.; GRITZO,LOUIS A.

    2000-02-14

    A spray-suppression model that captures the effects of liquid suppressant on a turbulent combusting flow is developed and applied to a turbulent diffusion flame with water spray suppression. The spray submodel is based on a stochastic separated flow approach that accounts for the transport and evaporation of liquid droplets. Flame extinguishment is accounted for by using a perfectly stirred reactor (PSR) submodel of turbulent combustion. PSR pre-calculations of flame extinction times are determined using CHEMKIN and are compared to local turbulent time scales of the flow to determine if local flame extinguishment has occurred. The PSR flame extinguishment and spray submodels are incorporated into Sandia's flow fire simulation code, VULCAN, and cases are run for the water spray suppression studies of McCaffrey for turbulent hydrogen-air jet diffusion flames. Predictions of flame temperature decrease and suppression efficiency are compared to experimental data as a function of water mass loading using three assumed values of drop sizes. The results show that the suppression efficiency is highly dependent on the initial droplet size for a given mass loading. A predicted optimal suppression efficiency was observed for the smallest class of droplets while the larger drops show increasing suppression efficiency with increasing mass loading for the range of mass loadings considered. Qualitative agreement to the experiment of suppression efficiency is encouraging, however quantitative agreement is limited due to the uncertainties in the boundary conditions of the experimental data for the water spray.

  18. Simulations of the electron cloud buildups and suppressions in...

    Office of Scientific and Technical Information (OSTI)

    Simulations of the electron cloud buildups and suppressions in Tevatron and main injector Citation Details In-Document Search Title: Simulations of the electron cloud buildups and ...

  19. Mechanisms Contributing to Suppressed Precipitation in Mt. Hua...

    Office of Scientific and Technical Information (OSTI)

    Consistent with the increase of air pollution in these regions, it has been argued that the precipitation trend is linked to aerosol microphysical effect on suppressing warm rain. ...

  20. Enhancement and Suppression of Photocurrent in Si Photodiodes by

    Office of Scientific and Technical Information (OSTI)

    Nanoparticles and Nonlinear Terahertz Superconducting Metamaterials (Technical Report) | SciTech Connect Enhancement and Suppression of Photocurrent in Si Photodiodes by Nanoparticles and Nonlinear Terahertz Superconducting Metamaterials Citation Details In-Document Search Title: Enhancement and Suppression of Photocurrent in Si Photodiodes by Nanoparticles and Nonlinear Terahertz Superconducting Metamaterials Authors: Grady, Nathaniel [1] + Show Author Affiliations Los Alamos National

  1. Suppressed-fission ICF hybrid reactor

    SciTech Connect (OSTI)

    Hogan, W.J.; Meier, W.R.

    1986-05-20

    A suppressed-fission ICF hybrid reactor has been designed to maximize the production of /sup 233/U. In this design, Be is used as a neutron multiplier. An annular array of Be columns surrounds the fusion pulse inside the reaction chember. The Be columns consist of short cylinders of Be joined together with steel snap rings. Vertical holes in the Be carry liquid lithium coolant and steel-clad thorium fuel pins. The lithium coolant is supplied at the top of the chamber, traverses through the Be columns and exits at the bottom. The columns are attached to top and bottom plates in such a way as to tolerate radiation-induced swelling and the vibrations resulting from each fusion pulse. A thin (10 cm) liquid Li fall region protects the Be columns from direct exposure to the X-rays and debris emitted by the fuel capsule. A neutronics study of this design indicates that the specific production of /sup 233/U fuel is increased by operating at relatively large thorium volume fractions. A design at a fertile fuel fraction of 30 vol % produces a total breeding ratio of over 2.1. The /sup 6/Li to /sup 7/Li ratio is adjusted to keep the tritium breeding ratio at about 1.0. In such a reactor, about 3400 kg of /sup 233/U can be produced per full power year at a fusion power level of 800 MW. Reactor support ratios greater than 13 can be achieved, leading to beneficial results even if the fusion reactor cost is significantly greater than that of a fission reactor.

  2. Quadrature mixture LO suppression via DSW DAC noise dither

    DOE Patents [OSTI]

    Dubbert, Dale F. (Cedar Crest, NM); Dudley, Peter A. (Albuquerque, NM)

    2007-08-21

    A Quadrature Error Corrected Digital Waveform Synthesizer (QECDWS) employs frequency dependent phase error corrections to, in effect, pre-distort the phase characteristic of the chirp to compensate for the frequency dependent phase nonlinearity of the RF and microwave subsystem. In addition, the QECDWS can employ frequency dependent correction vectors to the quadrature amplitude and phase of the synthesized output. The quadrature corrections cancel the radars' quadrature upconverter (mixer) errors to null the unwanted spectral image. A result is the direct generation of an RF waveform, which has a theoretical chirp bandwidth equal to the QECDWS clock frequency (1 to 1.2 GHz) with the high Spurious Free Dynamic Range (SFDR) necessary for high dynamic range radar systems such as SAR. To correct for the problematic upconverter local oscillator (LO) leakage, precision DC offsets can be applied over the chirped pulse using a pseudo-random noise dither. The present dither technique can effectively produce a quadrature DC bias which has the precision required to adequately suppress the LO leakage. A calibration technique can be employed to calculate both the quadrature correction vectors and the LO-nulling DC offsets using the radar built-in test capability.

  3. Suppressing spectral diffusion of emitted photons with optical pulses

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Fotso, H. F.; Feiguin, A. E.; Awschalom, D. D.; Dobrovitski, V. V.

    2016-01-22

    In many quantum architectures the solid-state qubits, such as quantum dots or color centers, are interfaced via emitted photons. However, the frequency of photons emitted by solid-state systems exhibits slow uncontrollable fluctuations over time (spectral diffusion), creating a serious problem for implementation of the photon-mediated protocols. Here we show that a sequence of optical pulses applied to the solid-state emitter can stabilize the emission line at the desired frequency. We demonstrate efficiency, robustness, and feasibility of the method analytically and numerically. Taking nitrogen-vacancy center in diamond as an example, we show that only several pulses, with the width of 1more » ns, separated by few ns (which is not difficult to achieve) can suppress spectral diffusion. As a result, our method provides a simple and robust way to greatly improve the efficiency of photon-mediated entanglement and/or coupling to photonic cavities for solid-state qubits.« less

  4. Enhancement and Suppression of Photocurrent in Si Photodiodes by

    Office of Scientific and Technical Information (OSTI)

    Nanoparticles and Nonlinear Terahertz Superconducting Metamaterials (Technical Report) | SciTech Connect Enhancement and Suppression of Photocurrent in Si Photodiodes by Nanoparticles and Nonlinear Terahertz Superconducting Metamaterials Citation Details In-Document Search Title: Enhancement and Suppression of Photocurrent in Si Photodiodes by Nanoparticles and Nonlinear Terahertz Superconducting Metamaterials × You are accessing a document from the Department of Energy's (DOE) SciTech

  5. Mechanisms Contributing to Suppressed Precipitation in Mt. Hua of Central

    Office of Scientific and Technical Information (OSTI)

    China, Part I: Mountain Valley Circulation (Journal Article) | SciTech Connect Mechanisms Contributing to Suppressed Precipitation in Mt. Hua of Central China, Part I: Mountain Valley Circulation Citation Details In-Document Search Title: Mechanisms Contributing to Suppressed Precipitation in Mt. Hua of Central China, Part I: Mountain Valley Circulation Significant reduction in precipitation in the past decades has been documented over many mountain ranges such as those in central and

  6. Methods for suppressing isomerization of olefin metathesis products

    DOE Patents [OSTI]

    Firth, Bruce E.; Kirk, Sharon E.

    2015-10-27

    A method for suppressing isomerization of an olefin metathesis product produced in a metathesis reaction includes adding an isomerization suppression agent that includes nitric acid to a mixture that includes the olefin metathesis product and residual metathesis catalyst from the metathesis reaction under conditions that are sufficient to passivate at least a portion of the residual metathesis catalyst. Methods of refining a natural oil are described.

  7. Mode of ATM-dependent suppression of chromosome translocation

    SciTech Connect (OSTI)

    Yamauchi, Motohiro; Suzuki, Keiji; Oka, Yasuyoshi; Suzuki, Masatoshi; Kondo, Hisayoshi; Yamashita, Shunichi

    2011-12-09

    Highlights: Black-Right-Pointing-Pointer We addressed how ATM suppresses frequency of chromosome translocation. Black-Right-Pointing-Pointer We found ATM/p53-dependent G1 checkpoint suppresses translocation frequency. Black-Right-Pointing-Pointer We found ATM and DNA-PKcs function in a common pathway to suppress translocation. -- Abstract: It is well documented that deficiency in ataxia telangiectasia mutated (ATM) protein leads to elevated frequency of chromosome translocation, however, it remains poorly understood how ATM suppresses translocation frequency. In the present study, we addressed the mechanism of ATM-dependent suppression of translocation frequency. To know frequency of translocation events in a whole genome at once, we performed centromere/telomere FISH and scored dicentric chromosomes, because dicentric and translocation occur with equal frequency and by identical mechanism. By centromere/telomere FISH analysis, we confirmed that chemical inhibition or RNAi-mediated knockdown of ATM causes 2 to 2.5-fold increase in dicentric frequency at first mitosis after 2 Gy of gamma-irradiation in G0/G1. The FISH analysis revealed that ATM/p53-dependent G1 checkpoint suppresses dicentric frequency, since RNAi-mediated knockdown of p53 elevated dicentric frequency by 1.5-fold. We found ATM also suppresses dicentric occurrence independently of its checkpoint role, as ATM inhibitor showed additional effect on dicentric frequency in the context of p53 depletion and Chk1/2 inactivation. Epistasis analysis using chemical inhibitors revealed that ATM kinase functions in the same pathway that requires kinase activity of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to suppress dicentric frequency. From the results in the present study, we conclude that ATM minimizes translocation frequency through its commitment to G1 checkpoint and DNA double-strand break repair pathway that requires kinase activity of DNA-PKcs.

  8. Suppression criteria of parasitic mode oscillations in a gyrotron beam tunnel

    SciTech Connect (OSTI)

    Kumar, Nitin; Singh, Udaybir; Sinha, A. K.; Singh, T. P.

    2011-02-15

    This paper presents the design criteria of the parasitic mode oscillations suppression for a periodic, ceramic, and copper loaded gyrotron beam tunnel. In such a type of beam tunnel, the suppression of parasitic mode oscillations is an important design problem. A method of beam-wave coupling coefficient and its mathematical formulation are presented. The developed design criteria are used in the beam tunnel design of a 42 GHz gyrotron to be developed for the Indian TOKAMAK system. The role of the thickness and the radius of the beam tunnel copper rings to obtain the developed design criteria are also discussed. The commercially available electromagnetic code CST and the electron trajectory code EGUN are used for the simulations.

  9. Arsenite suppression of BMP signaling in human keratinocytes

    SciTech Connect (OSTI)

    Phillips, Marjorie A.; Qin, Qin; Hu, Qin; Zhao, Bin; Rice, Robert H.

    2013-06-15

    Arsenic, a human skin carcinogen, suppresses differentiation of cultured keratinocytes. Exploring the mechanism of this suppression revealed that BMP-6 greatly increased levels of mRNA for keratins 1 and 10, two of the earliest differentiation markers expressed, a process prevented by co-treatment with arsenite. BMP also stimulated, and arsenite suppressed, mRNA for FOXN1, an important transcription factor driving early keratinocyte differentiation. Keratin mRNAs increased slowly after BMP-6 addition, suggesting they are indirect transcriptional targets. Inhibition of Notch1 activation blocked BMP induction of keratins 1 and 10, while FOXN1 induction was largely unaffected. Supporting a requirement for Notch1 signaling in keratin induction, BMP increased levels of activated Notch1, which was blocked by arsenite. BMP also greatly decreased active ERK, while co-treatment with arsenite maintained active ERK. Inhibition of ERK signaling mimicked BMP by inducing keratin and FOXN1 mRNAs and by increasing active Notch1, effects blocked by arsenite. Of 6 dual-specificity phosphatases (DUSPs) targeting ERK, two were induced by BMP unless prevented by simultaneous exposure to arsenite and EGF. Knockdown of DUSP2 or DUSP14 using shRNAs greatly reduced FOXN1 and keratins 1 and 10 mRNA levels and their induction by BMP. Knockdown also decreased activated Notch1, keratin 1 and keratin 10 protein levels, both in the presence and absence of BMP. Thus, one of the earliest effects of BMP is induction of DUSPs, which increases FOXN1 transcription factor and activates Notch1, both required for keratin gene expression. Arsenite prevents this cascade by maintaining ERK signaling, at least in part by suppressing DUSP expression. - Highlights: BMP induces FOXN1 transcription. BMP induces DUSP2 and DUSP14, suppressing ERK activation. Arsenite suppresses levels of phosphorylated Smad1/5 and FOXN1 and DUSP mRNA. These actions rationalize arsenite suppression of keratinocyte differentiation.

  10. A simplified model of decontamination by BWR steam suppression pools

    SciTech Connect (OSTI)

    Powers, D.A.

    1997-05-01

    Phenomena that can decontaminate aerosol-laden gases sparging through steam suppression pools of boiling water reactors during reactor accidents are described. Uncertainties in aerosol properties, aerosol behavior within gas bubbles, and bubble behavior in plumes affect predictions of decontamination by steam suppression pools. Uncertainties in the boundary and initial conditions that are dictated by the progression of severe reactor accidents and that will affect predictions of decontamination by steam suppression pools are discussed. Ten parameters that characterize boundary and initial condition uncertainties, nine parameters that characterize aerosol property and behavior uncertainties, and eleven parameters that characterize uncertainties in the behavior of bubbles in steam suppression pools are identified. Ranges for the values of these parameters and subjective probability distributions for parametric values within the ranges are defined. These uncertain parameters are used in Monte Carlo uncertainty analyses to develop uncertainty distributions for the decontamination that can be achieved by steam suppression pools and the size distribution of aerosols that do emerge from such pools. A simplified model of decontamination by steam suppression pools is developed by correlating features of the uncertainty distributions for total decontamination factor, DF(total), mean size of emerging aerosol particles, d{sub p}, and the standard deviation of the emerging aerosol size distribution, {sigma}, with pool depth, H. Correlations of the median values of the uncertainty distributions are suggested as the best estimate of decontamination by suppression pools. Correlations of the 10 percentile and 90 percentile values of the uncertainty distributions characterize the uncertainty in the best estimates. 295 refs., 121 figs., 113 tabs.

  11. Radar signal pre-processing to suppress surface bounce and multipath

    DOE Patents [OSTI]

    Paglieroni, David W; Mast, Jeffrey E; Beer, N. Reginald

    2013-12-31

    A method and system for detecting the presence of subsurface objects within a medium is provided. In some embodiments, the imaging and detection system operates in a multistatic mode to collect radar return signals generated by an array of transceiver antenna pairs that is positioned across the surface and that travels down the surface. The imaging and detection system pre-processes that return signal to suppress certain undesirable effects. The imaging and detection system then generates synthetic aperture radar images from real aperture radar images generated from the pre-processed return signal. The imaging and detection system then post-processes the synthetic aperture radar images to improve detection of subsurface objects. The imaging and detection system identifies peaks in the energy levels of the post-processed image frame, which indicates the presence of a subsurface object.

  12. Calculation of Fire Severity Factors and Fire Non-Suppression Probabilities For A DOE Facility Fire PRA

    SciTech Connect (OSTI)

    Tom Elicson; Bentley Harwood; Jim Bouchard; Heather Lucek

    2011-03-01

    Over a 12 month period, a fire PRA was developed for a DOE facility using the NUREG/CR-6850 EPRI/NRC fire PRA methodology. The fire PRA modeling included calculation of fire severity factors (SFs) and fire non-suppression probabilities (PNS) for each safe shutdown (SSD) component considered in the fire PRA model. The SFs were developed by performing detailed fire modeling through a combination of CFAST fire zone model calculations and Latin Hypercube Sampling (LHS). Component damage times and automatic fire suppression system actuation times calculated in the CFAST LHS analyses were then input to a time-dependent model of fire non-suppression probability. The fire non-suppression probability model is based on the modeling approach outlined in NUREG/CR-6850 and is supplemented with plant specific data. This paper presents the methodology used in the DOE facility fire PRA for modeling fire-induced SSD component failures and includes discussions of modeling techniques for: • Development of time-dependent fire heat release rate profiles (required as input to CFAST), • Calculation of fire severity factors based on CFAST detailed fire modeling, and • Calculation of fire non-suppression probabilities.

  13. Experience with IBS-suppression lattice in RHIC

    SciTech Connect (OSTI)

    Litvinenko,V.N.; Luo, Y.; Ptitsyn, V.; Satogata, T.; Tepikian, S.; Bai, M.; Bruno, D.; Cameron, P.; Connolly, R.; Della Penna, A.; Drees, A.; Fedotov, A.; Ganetis, G.; Hoff, L.; Louie, W.; Malitsky, N.; Marr, G.; Marusic, A.; Montag, C.; Pilat, F.; Roser, T.; Trbojevic, D.; Tsoupas, N.

    2008-06-23

    An intra-beam scattering (IBS) is the limiting factor of the luminosity lifetime for RHIC operating with heavy ions. In order to suppress the IBS we designed and implemented new lattice with higher betatron tunes. This lattice had been developed during last three years and had been used for gold ions in yellow ring of the RHIC during d-Au part of the RHIC Run-8. The use of this lattice allowed both significant increases in the luminosity lifetime and the luminosity levels via reduction of beta-stars in the IPS. In this paper we report on the development, the tests and the performance of IBS-suppression lattice in RHIC, including the resulting increases in the peak and the average luminosity. We also report on our plans for future steps with the IBS suppression.

  14. IBS suppression lattice in RHIC: theory and experimental verification

    SciTech Connect (OSTI)

    Fedotov,A.V.; Bai, M.; Bruno, D.; Cameron, P.; Connolly, R.; Cupolo, J.; Della Penna, A.; Drees, A.; Fischer, W.; Ganetis, G.; Hoff, L.; Litvinenko, V.N.; Louie, W.; Luo, Y.; Malitsky, N.; Marr, G.; Marusic, A.; Montag, C.; Ptitsyn, V.; Roser, T.; Satogata, T.; Tepikian, S.; Trbojevic, D.; Tsoupas, N.

    2008-08-25

    Intra-beam scattering (IBS) is the limiting factor of the luminosity lifetime for Relativistic Heavy Ion Collider (RHIC) operation with heavy ions. Over the last few years the process of IBS was carefully studied in RHIC with dedicated IBS measurements and their comparison with the theoretical models. A new lattice was recently designed and implemented in RHIC to suppress transverse IBS growth, which lowered the average arc dispersion by about 20% [1]. This lattice became operational during RHIC Run-8. We review the IBS suppression mechanism, IBS measurements before and after the lattice change, and comparisons with predictions.

  15. Using multiple perspectives to suppress information and complexity

    SciTech Connect (OSTI)

    Kelsey, R.L. |; Webster, R.B.; Hartley, R.T.

    1998-09-01

    Dissemination of battlespace information involves getting information to particular warfighters that is both useful and in a form that facilitates the tasks of those particular warfighters. There are two issues which motivate this problem of dissemination. The first issue deals with disseminating pertinent information to a particular warfighter. This can be thought of as information suppression. The second issue deals with facilitating the use of the information by tailoring the computer interface to the specific tasks of an individual warfighter. This can be thought of as interface complexity suppression. This paper presents a framework for suppressing information using an object-based knowledge representation methodology. This methodology has the ability to represent knowledge and information in multiple perspectives. Information can be suppressed by creating a perspective specific to an individual warfighter. In this way, only the information pertinent and useful to a warfighter is made available to that warfighter. Information is not removed, lost, or changed, but spread among multiple perspectives. Interface complexity is managed in a similar manner. Rather than have one generalized computer interface to access all information, the computer interface can be divided into interface elements. Interface elements can then be selected and arranged into a perspective-specific interface. This is done in a manner to facilitate completion of tasks contained in that perspective. A basic battlespace domain containing ground and air elements and associated warfighters is used to exercise the methodology.

  16. Fission-suppressed hybrid reactor: the fusion breeder

    SciTech Connect (OSTI)

    Moir, R.W.; Lee, J.D.; Coops, M.S.

    1982-12-01

    Results of a conceptual design study of a /sup 233/U-producing fusion breeder are presented. The majority of the study was devoted to conceptual design and evaluation of a fission-suppressed blanket and to fuel cycle issues such as fuel reprocessing, fuel handling, and fuel management. Studies in the areas of fusion engineering, reactor safety, and economics were also performed.

  17. Suppression Pool Mixing and Condensation Tests in PUMA Facility

    SciTech Connect (OSTI)

    Ling Cheng; Kyoung Suk Woo; Mamoru Ishii; Jaehyok Lim; Han, James

    2006-07-01

    Condensation of steam with non-condensable in the form of jet flow or bubbly flow inside the suppression pool is an important phenomenon on determining the containment pressure of a passively safe boiling water reactor. 32 cases of pool mixing and condensation test have been performed in Purdue University Multi-Dimensional Integral Test Assembly (PUMA) facility under the sponsor of the U.S. Nuclear Regulatory Commission to investigate thermal stratification and pool mixing inside the suppression pool during the reactor blowdown period. The test boundary conditions, such as the steam flow rate, the noncondensable gas flow rate, the initial water temperature, the pool initial pressure and the vent opening submergence depth, which covers a wide range of prototype (SBWR-600) conditions during Loss of Coolant Accident (LOCA) were obtained from the RELAP5 calculation. The test results show that steam is quickly condensed at the exit of the vent opening. For pure steam injection or low noncondensable injection cases, only the portion above the vent opening in the suppression pool is heated up by buoyant plumes. The water below the vent opening can be heated up slowly through conduction. The test results also show that the degree of thermal stratification in suppression pool is affected by the vent opening submergence depth, the pool initial pressure and the steam injection rate. And it is slightly affected by the initial water temperature. From these tests it is concluded that the pool mixing is strongly affected by the noncondensable gas flow rate. (authors)

  18. Low Dose Suppression of Neoplastic Transformation in Vitro

    SciTech Connect (OSTI)

    John Leslie Redpath

    2012-05-01

    This grant was to study the low dose suppression of neoplastic transformation in vitro and the shape of the dose-response curve at low doses and dose-rates of ionizing radiation. Previous findings had indicated a suppression of transformation at dose <10cGy of low-LET radiation when delivered at high dose-rate. The present study indicates that such suppression extends out to doses in excess of 100cGy when the dose (from I-125 photons) is delivered at dose-rates as low as 0.2 mGy/min and out to in excess of {approx}25cGy the highest dose studied at the very low dose-rate of 0.5 mGy/day. We also examined dose-rate effects for high energy protons (which are a low-LET radiation) and suppression was evident below {approx}10cGy for high dose-rate delivery and at least out to 50cGy for low dose-rate (20cGy/h) delivery. Finally, we also examined the effect of low doses of 1 GeV/n iron ions (a high-LET radiation) delivered at high dose-rate on transformation at low doses and found a suppression below {approx}10cGy that could be attributable to an adaptive response in bystander cells induced by the associated low-LET delta rays. These results have implications for cancer risk assessment at low doses.

  19. MOLECULAR MECHANISM OF SUPPRESSION OF NEOPLASTIC TRANSFORMATION BY LOW DOSES OF LOW LET RADIATION

    SciTech Connect (OSTI)

    J.LESIE REDPATH, PH.D.

    2011-03-29

    We are currently funded (9/01-8/04) by the DOE Low Dose Radiation Research Program to examine mechanisms underlying the suppression of neoplastic transformation in vitro by low doses of low LET radiation. For the new studies proposed under Notice 04-21, we intend to follow up on our observation that upregulation of DNA repair may be an important factor and that its importance is dose-dependent. The experimental system will be the human hybrid cell neoplastic transformation assay that we are currently using. We propose to test the following hypothesis: Down-regulation of DNA dsb repair will abrogate the low dose suppression of neoplastic transformation. Using the technique of RNA silencing, it is proposed to test the effect of down-regulation of the two major DNA dsb repair pathways, homologous recombination (HR) and non-homologous end-joining (NHEJ), on the dose response relationship for neoplastic transformation. Based on prior studies, we predict that this will result in abrogation of the suppressive effect at doses in the range 1 to 10 cGy, but not at lower doses. The proposed experiments will also help address the question as to which of the two DNA repair pathways may be the most important in causing suppression of transformation. HR is a pathway that is predominant in S and G2 phase cells and is known to be less error-prone than the NHEJ pathway that is predominant in G1 phase. We hypothesize that down-regulation of HR will result in the most effective abrogation of suppression. An important component of this study will be the determination of the how abrogation of DNA dsb repair impacts the spontaneous transformation frequency, presumably a consequence of endogeneous DNA damage. Experiments will be carried out using partially synchronized populations of cells enriched for G1 and S/G2 respectively. In addition to the endpoint of neoplastic transformation the impact of down-regulation of HR and NHEJ on the formation and disappearance of the DNA dsb marker, gamma-H2AX, will be studied.

  20. Dynamics of double layers, ion acceleration, and heat flux suppression during solar flares

    SciTech Connect (OSTI)

    Li, T. C.; Drake, J. F.; Swisdak, M.

    2014-09-20

    Observations of flare-heated electrons in the corona typically suggest confinement of electrons. The confinement mechanism, however, remains unclear. The transport of coronal hot electrons into ambient plasma was recently investigated by particle-in-cell (PIC) simulations. Electron transport was significantly suppressed by the formation of a highly localized, nonlinear electrostatic potential in the form of a double layer (DL). In this work large-scale PIC simulations are performed to explore the dynamics of DLs in larger systems where, instead of a single DL, multiple DLs are generated. The primary DL accelerates return current electrons, resulting in high velocity electron beams that interact with ambient ions. This forms a Buneman unstable system that spawns more DLs. Trapping of heated return current electrons between multiple DLs strongly suppresses electron transport. DLs also accelerate ambient ions and produce strong ion flows over an extended region. This clarifies the mechanism by which hot electrons in the corona couple to and accelerate ions to form the solar wind. These new dynamics in larger systems reveal a more likely picture of DL development and their impact on the ambient plasma in the solar corona. They are applicable to the preparation for in situ coronal space missions like the Solar Probe Plus.

  1. Apparatus and method for suppressing vibration and displacement of a bellows

    DOE Patents [OSTI]

    Kuklo, T.C.

    1984-01-01

    Flexible bellows are utilized between two systems, such as a pumping system and a process station, to partially absorb system vibrations and to compensate for misalignment between the systems. It is common practice to either clamp a rigid spacer between flanges of the two systems to separate them from each other, or to maintain the bellows in unsupported relationship between these systems. In the former bellows arrangement, the rigid spacer transmits vibratory energy between the two systems and the bellows tends to function as an undamped or underdamped unit that resonates at its own frequency to create additional vibratory energy, transmitted to the systems. In the latter, unsupported bellows arrangement, the pressure differential prevalent between the fluid flowing through the bellows and ambient normally causes extension or retraction of the bellows and resulting misalignment problems. The present invention substantially solves the above vibration and misalignment problems by providing an inflatable tube in surrounding relationship about a bellows to suppress vibration and displacement thereof. A method for isolating first and second systems from each other to prevent the transmission of vibratory energy therebetween comprises the steps of attaching at least one flexible bellows between the systems, surrounding the bellows with an inflatable tube, and maintaining a predetermined pressure in the tube to urge the tube in flexible contact with at least some of the convolutions of the bellows.

  2. Apparatus and method for suppressing vibration and displacement of a bellows

    DOE Patents [OSTI]

    Kuklo, Thomas C.

    1985-01-01

    Flexible bellows are utilized between two systems, such as a pumping system and a process station, to partially absorb system vibrations and to compensate for misalignment between the systems. It is common practice to either clamp a rigid spacer between flanges of the two systems (FIG. 3B) to separate them from each other, or to maintain the bellows in unsupported relationship between these systems (FIG. 4B). In the former bellows arrangement, the rigid spacer transmits vibratory energy between the two systems and the bellows tends to function as an undamped or underdamped unit that resonates at its own frequency to create additional vibratory energy, transmitted to the systems. In the latter, unsupported bellows arrangement (FIG. 4B), the pressure differential prevalent between the fluid flowing through the bellows and ambient normally causes extension or retraction of the bellows and resulting misalignment problems. The present invention substantially solves the above vibration and misalignment problems by providing an inflatable tube (20) in surrounding relationship about a bellows (14) to suppress vibration and displacement thereof. A method for isolating first and second systems (11,12) from each other to prevent the transmission of vibratory energy therebetween comprises the steps of attaching at least one flexible bellows (14) between the systems (11,12), surrounding the bellows with an inflatable tube (20), and maintaining a predetermined pressure in the tube (20) to urge the tube in flexible contact with at least some of the convolutions of the bellows (14).

  3. Suppression of Rayleigh Taylor instability in strongly coupled plasmas

    SciTech Connect (OSTI)

    Das, Amita; Kaw, Predhiman [Institute for Plasma Research, Bhat, Gandhinagar 382428 (India)

    2014-06-15

    The Rayleigh Taylor instability in a strongly coupled plasma medium has been investigated using the equations of generalized hydrodynamics. It is demonstrated that the visco-elasticity of the strongly coupled medium due to strong inter particle correlations leads to a suppression of the Rayleigh Taylor instability unless certain threshold conditions are met. The relevance of these results to experiments on laser compression of matter to high densities including those related to inertial confinement fusion using lasers has also been shown.

  4. Suppression of quantum chaos in a quantum computer hardware

    SciTech Connect (OSTI)

    Lages, J.; Shepelyansky, D. L. [Laboratoire de Physique Theorique, UMR 5152 du CNRS, Universite Paul Sabatier, 31062 Toulouse Cedex 4 (France)

    2006-08-15

    We present numerical and analytical studies of a quantum computer proposed by the Yamamoto group in Phys. Rev. Lett. 89, 017901 (2002). The stable and quantum chaos regimes in the quantum computer hardware are identified as a function of magnetic field gradient and dipole-dipole couplings between qubits on a square lattice. It is shown that a strong magnetic field gradient leads to suppression of quantum chaos.

  5. Suppression of auger recombination in ""giant"" core/shell nanocrystals

    SciTech Connect (OSTI)

    Garcia Santamaria, Florencio; Vela, Javier; Schaller, Richard D; Hollingsworth, Jennifer A; Klimov, Victor I; Chen, Yongfen

    2009-01-01

    Many potential applications of semiconductor nanocrystals are hindered by nonradiative Auger recombination wherein the electron-hole (exciton) recombination energy is transferred to a third charge carrier. This process severely limits the lifetime and bandwidth of optical gain, leads to large nonradiative losses in light emitting diodes and photovoltaic cells, and is believed to be responsible for intermittency ('blinking') of emission from single nanocrystals. The development of nanostructures in which Auger recombination is suppressed has been a longstanding goal in colloidal nanocrystal research. Here, we demonstrate that such suppression is possible using so-called 'giant' nanocrystals that consist of a small CdSe core and a thick CdS shell. These nanostructures exhibit a very long biexciton lifetime ({approx}10 ns) that is likely dominated by radiative decay instead of non-radiative Auger recombination. As a result of suppressed Auger recombination, even high-order multiexcitons exhibit high emission efficiencies, which allows us to demonstrate optical amplification with an extraordinarily large bandwidth (>500 me V) and record low excitation thresholds.

  6. Inhibiting voltage suppression in lithium/fluorinated carbon batteries

    SciTech Connect (OSTI)

    Shia, G.A.; Nalewajek, D.; Pyszczek, M.F.

    1988-12-13

    This patent describes a lithium/fluorinated carbon battery having a reduced initial voltage suppression which comprises the incorporation in the battery cathode of fluorinated carbon which has been reacted with a compound selected from the group consisting of a Group IA metal-alkyl compound and a Group IA metal-aryl compound, which Group IA metal-aryl compound has at least 10 carbon atoms, until surface fluorine on the fluorinated carbon has been stripped and alkyl or aryl groups from the Group IA metal-alkyl compound or Group IA metal-aryl compound are substituted for surface fluorine atoms.

  7. Suppression of energetic particle driven instabilities with HHFW heating

    SciTech Connect (OSTI)

    Fredrickson, E. D.; Taylor, G.; Bertelli, N.; Darrow, D. S.; Gorelenkov, N.; Kramer, G.; Liu, D.; Crocker, N. A.; Kubota, S.; White, R.

    2015-01-01

    In plasmas in the National Spherical Torus Experiment (NSTX) [Ono et al., Nucl. Fusion 40 (2000) 557] heated with neutral beams, the beam ions typically excite Energetic Particle Modes (EPMs or fishbones), and Toroidal, Global or Compressional Alfvén Eigenmodes (TAE, GAE, CAE). These modes can redistribute the energetic beam ions, altering the beam driven current profile and the plasma heating profile, or they may affect electron thermal transport or cause losses of the beam ions. In this paper we present experimental results where these instabilities, driven by the super-thermal beam ions, are suppressed with the application of High Harmonic Fast Wave heating.

  8. Suppression of energetic particle driven instabilities with HHFW heating

    SciTech Connect (OSTI)

    Fredrickson, E. D.; Taylor, G.; Bertelli, N.; Darrow, D. S.; Gorelenkov, N.; Kramer, G.; Liu, D.; Crocker, N. A.; Kubota, S.; White, R.

    2015-01-01

    In plasmas in the National Spherical Torus Experiment (NSTX) [Ono et al., Nucl. Fusion 40 (2000) 557] heated with neutral beams, the beam ions typically excite Energetic Particle Modes (EPMs or fishbones), and Toroidal, Global or Compressional Alfvn Eigenmodes (TAE, GAE, CAE). These modes can redistribute the energetic beam ions, altering the beam driven current profile and the plasma heating profile, or they may affect electron thermal transport or cause losses of the beam ions. In this paper we present experimental results where these instabilities, driven by the super-thermal beam ions, are suppressed with the application of High Harmonic Fast Wave heating.

  9. Deconfinement as an entropic self-destruction: A solution for the quarkonium suppression puzzle?

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kharzeev, Dmitri E.

    2014-10-02

    The entropic approach to dissociation of bound states immersed in strongly coupled systems is developed. In such systems, the excitations of the bound state are often delocalized and characterized by a large entropy, so that the bound state is strongly entangled with the rest of the statistical system. If this entropy S increases with the separation r between the constituents of the bound state, S=S(r), then the resulting entropic force F=T ∂S/∂r (T is temperature) can drive the dissociation process. As a specific example, we consider the case of heavy quarkonium in strongly coupled quark-gluon plasma, where lattice QCD indicatesmore » a large amount of entropy associated with the heavy quark pair at temperatures 0.9Tc ≤ T ≤ 1.5Tc (Tc is the deconfinement temperature); this entropy S(r) grows with the interquark distance r. We argue that the entropic mechanism results in an anomalously strong quarkonium suppression in the temperature range near Tc. This entropic self-destruction may thus explain why the experimentally measured quarkonium nuclear modification factor at RHIC (lower energy density) is smaller than at LHC (higher energy density), possibly resolving the “quarkonium suppression puzzle”—all of the previously known mechanisms of quarkonium dissociation operate more effectively at higher energy densities, and this contradicts the data. As a result, we find that near Tc the entropic force leads to delocalization of the bound hadron states; we argue that this delocalization may be the mechanism underlying deconfinement.« less

  10. Simulation of Thermal Stratification in BWR Suppression Pools with One Dimensional Modeling Method

    SciTech Connect (OSTI)

    Haihua Zhao; Ling Zou; Hongbin Zhang

    2014-01-01

    The suppression pool in a boiling water reactor (BWR) plant not only is the major heat sink within the containment system, but also provides the major emergency cooling water for the reactor core. In several accident scenarios, such as a loss-of-coolant accident and extended station blackout, thermal stratification tends to form in the pool after the initial rapid venting stage. Accurately predicting the pool stratification phenomenon is important because it affects the peak containment pressure; the pool temperature distribution also affects the NPSHa (available net positive suction head) and therefore the performance of the Emergency Core Cooling System and Reactor Core Isolation Cooling System pumps that draw cooling water back to the core. Current safety analysis codes use zero dimensional (0-D) lumped parameter models to calculate the energy and mass balance in the pool; therefore, they have large uncertainties in the prediction of scenarios in which stratification and mixing are important. While three-dimensional (3-D) computational fluid dynamics (CFD) methods can be used to analyze realistic 3-D configurations, these methods normally require very fine grid resolution to resolve thin substructures such as jets and wall boundaries, resulting in a long simulation time. For mixing in stably stratified large enclosures, the BMIX++ code (Berkeley mechanistic MIXing code in C++) has been developed to implement a highly efficient analysis method for stratification where the ambient fluid volume is represented by one-dimensional (1-D) transient partial differential equations and substructures (such as free or wall jets) are modeled with 1-D integral models. This allows very large reductions in computational effort compared to multi-dimensional CFD modeling. One heat-up experiment performed at the Finland POOLEX facility, which was designed to study phenomena relevant to Nordic design BWR suppression pool including thermal stratification and mixing, is used for validation. Comparisons between the BMIX++, GOTHIC, and CFD calculations against the POOLEX experimental data are discussed in detail.

  11. Deconfinement as an entropic self-destruction: A solution for the quarkonium suppression puzzle?

    SciTech Connect (OSTI)

    Kharzeev, Dmitri E.

    2014-10-02

    The entropic approach to dissociation of bound states immersed in strongly coupled systems is developed. In such systems, the excitations of the bound state are often delocalized and characterized by a large entropy, so that the bound state is strongly entangled with the rest of the statistical system. If this entropy S increases with the separation r between the constituents of the bound state, S=S(r), then the resulting entropic force F=T ∂S/∂r (T is temperature) can drive the dissociation process. As a specific example, we consider the case of heavy quarkonium in strongly coupled quark-gluon plasma, where lattice QCD indicates a large amount of entropy associated with the heavy quark pair at temperatures 0.9Tc ≤ T ≤ 1.5Tc (Tc is the deconfinement temperature); this entropy S(r) grows with the interquark distance r. We argue that the entropic mechanism results in an anomalously strong quarkonium suppression in the temperature range near Tc. This entropic self-destruction may thus explain why the experimentally measured quarkonium nuclear modification factor at RHIC (lower energy density) is smaller than at LHC (higher energy density), possibly resolving the “quarkonium suppression puzzle”—all of the previously known mechanisms of quarkonium dissociation operate more effectively at higher energy densities, and this contradicts the data. As a result, we find that near Tc the entropic force leads to delocalization of the bound hadron states; we argue that this delocalization may be the mechanism underlying deconfinement.

  12. Slag foaming phenomena and its suppression techniques in BOF steelmaking process

    SciTech Connect (OSTI)

    Pak, J.J.; Min, D.J.; You, B.D.

    1996-12-31

    Some basic studies using the X-ray fluoroscopy technique were carried out to understand slag foaming phenomena in BOF process. The BOF slag in contact with hot metal showed a generation of very fine size CO bubbles at the slag-metal interface, and formed a stable foam. The lump iron ore added into BOF slag decomposed faster, but showed less foaming than sinter ore did. The anti-foaming agent and coke were added into foamed BOF slag to compare their effectiveness of foam suppression. At the same time, various attempts were made to control the excessive slag foaming during BOF operation. Practice modifications such as oxygen blowing pattern and ore addition, and the installation of the slopping control button were effective and significantly reduced slopping. The slopping detection system involving oxygen lance vibration measurements were on-line installed for prompt and accurate control of slag foaming in BOF converter.

  13. Extraordinary suppression of carrier scattering in large area graphene oxide films

    SciTech Connect (OSTI)

    Negishi, R. Kobayashi, Y.

    2014-12-22

    In this study, we find that thermal treatment in ethanol vapor has a remarkable suppression effect of carrier scattering occurring between reduced graphene oxide (rGO) flakes in large area films. We observe excellent electrical properties such as high carrier mobility (?5?cm{sup 2}/Vs) and low sheet resistance (?40?K?/?) for the rGO films. From the electrical conductivity analysis of large area rGO films using two-dimensional variable range hopping model and structural analysis using Raman spectra measured from the rGO films, we reveal that the significant effect is caused by the expansion of conjugated ?-electron system in rGO flake due to the efficient restoration of graphitic structure.

  14. Short wavelength limits of current shot noise suppression

    SciTech Connect (OSTI)

    Nause, Ariel; Dyunin, Egor; Gover, Avraham

    2014-08-15

    Shot noise in electron beam was assumed to be one of the features beyond control of accelerator physics. Current results attained in experiments at Accelerator Test Facility in Brookhaven and Linac Coherent Light Source in Stanford suggest that the control of the shot noise in electron beam (and therefore of spontaneous radiation and Self Amplified Spontaneous Emission of Free Electron Lasers) is feasible at least in the visible range of the spectrum. Here, we present a general linear formulation for collective micro-dynamics of e-beam noise and its control. Specifically, we compare two schemes for current noise suppression: a quarter plasma wavelength drift section and a combined drift/dispersive (transverse magnetic field) section. We examine and compare their limits of applicability at short wavelengths via considerations of electron phase-spread and the related Landau damping effect.

  15. Method of inhibiting voltage suppression lithium/fluorinated carbon batteries

    SciTech Connect (OSTI)

    Shia, G.A.; Friedland, D.J.

    1987-08-11

    An improved lithium/fluorinated carbon battery is described wherein the cathode comprises a blend of at least two different CF/sub x/ compositions which are derived from petroleum-based coke products which have been prepared by heat treatment at a temperature between about 800/sup 0/C and 2,0006/sup 0/C: (a) a bulk CF/sub x/ and (b) an additive CF/sub x/ and wherein from about 0.5 percent to about 50 percent of (b) is characterized as having a closed circuit voltage of at least 150 mV above the plateau voltage of the bulk CF/sub x/ and a specific capacity above 600 mAH/g. A method is also described for the elimination of suppression of the closed circuit voltage of a Li/CF/sub x/ battery during the initial part of its discharge.

  16. Suppression of energetic particle driven instabilities with HHFW heating

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Fredrickson, E. D.; Taylor, G.; Bertelli, N.; Darrow, D. S.; Gorelenkov, N.; Kramer, G.; Liu, D.; Crocker, N. A.; Kubota, S.; White, R.

    2015-01-01

    In plasmas in the National Spherical Torus Experiment (NSTX) [Ono et al., Nucl. Fusion 40 (2000) 557] heated with neutral beams, the beam ions typically excite Energetic Particle Modes (EPMs or fishbones), and Toroidal, Global or Compressional Alfvén Eigenmodes (TAE, GAE, CAE). These modes can redistribute the energetic beam ions, altering the beam driven current profile and the plasma heating profile, or they may affect electron thermal transport or cause losses of the beam ions. In this paper we present experimental results where these instabilities, driven by the super-thermal beam ions, are suppressed with the application of High Harmonic Fastmore » Wave heating.« less

  17. Method and apparatus for suppressing waves in a borehole

    DOE Patents [OSTI]

    West, Phillip B.

    2005-10-04

    Methods and apparatus for suppression of wave energy within a fluid-filled borehole using a low pressure acoustic barrier. In one embodiment, a flexible diaphragm type device is configured as an open bottomed tubular structure for disposition in a borehole to be filled with a gas to create a barrier to wave energy, including tube waves. In another embodiment, an expandable umbrella type device is used to define a chamber in which a gas is disposed. In yet another embodiment, a reverse acting bladder type device is suspended in the borehole. Due to its reverse acting properties, the bladder expands when internal pressure is reduced, and the reverse acting bladder device extends across the borehole to provide a low pressure wave energy barrier.

  18. Fission-suppressed fusion breeder on the thorium cycle and nonproliferation

    Office of Scientific and Technical Information (OSTI)

    (Journal Article) | SciTech Connect Journal Article: Fission-suppressed fusion breeder on the thorium cycle and nonproliferation Citation Details In-Document Search Title: Fission-suppressed fusion breeder on the thorium cycle and nonproliferation Fusion reactors could be designed to breed fissile material while suppressing fissioning thereby enhancing safety. The produced fuel could be used to startup and makeup fuel for fission reactors. Each fusion reaction can produce typically 0.6

  19. Study on higher harmonic suppression using edge filter and polished Si wafer

    SciTech Connect (OSTI)

    Gupta, R. K. Singh, Amol Modi, Mohammed H. Lodha, G. S.

    2014-04-24

    Higher harmonics contamination is a severe problem in synchrotron beamlines where grating monochromators are used. In these beamlines, absorption edge filters and critical angle mirrors are used to suppress the harmonic contaminations. In the present study, carried out using Indus-1 reflectivity beamline, a harmonic suppression characteristic of Al edge filter and polished silicon wafer are determined. It is found that the Al filter suppresses higher harmonics in 2–7% range whereas the polished silicon wafer can suppress the higher harmonics below 1%. The results of comparative study are discussed.

  20. An efficient modeling method for thermal stratification simulation in a BWR suppression pool

    SciTech Connect (OSTI)

    Haihua Zhao; Ling Zou; Hongbin Zhang; Hua Li; Walter Villanueva; Pavel Kudinov

    2012-09-01

    The suppression pool in a BWR plant not only is the major heat sink within the containment system, but also provides major emergency cooling water for the reactor core. In several accident scenarios, such as LOCA and extended station blackout, thermal stratification tends to form in the pool after the initial rapid venting stage. Accurately predicting the pool stratification phenomenon is important because it affects the peak containment pressure; and the pool temperature distribution also affects the NPSHa (Available Net Positive Suction Head) and therefore the performance of the pump which draws cooling water back to the core. Current safety analysis codes use 0-D lumped parameter methods to calculate the energy and mass balance in the pool and therefore have large uncertainty in prediction of scenarios in which stratification and mixing are important. While 3-D CFD methods can be used to analyze realistic 3D configurations, these methods normally require very fine grid resolution to resolve thin substructures such as jets and wall boundaries, therefore long simulation time. For mixing in stably stratified large enclosures, the BMIX++ code has been developed to implement a highly efficient analysis method for stratification where the ambient fluid volume is represented by 1-D transient partial differential equations and substructures such as free or wall jets are modeled with 1-D integral models. This allows very large reductions in computational effort compared to 3-D CFD modeling. The POOLEX experiments at Finland, which was designed to study phenomena relevant to Nordic design BWR suppression pool including thermal stratification and mixing, are used for validation. GOTHIC lumped parameter models are used to obtain boundary conditions for BMIX++ code and CFD simulations. Comparison between the BMIX++, GOTHIC, and CFD calculations against the POOLEX experimental data is discussed in detail.

  1. Kalispel Non-Native Fish Suppression Project 2007 Annual Report.

    SciTech Connect (OSTI)

    Wingert, Michele; Andersen, Todd

    2008-11-18

    Non-native salmonids are impacting native salmonid populations throughout the Pend Oreille Subbasin. Competition, hybridization, and predation by non-native fish have been identified as primary factors in the decline of some native bull trout (Salvelinus confluentus) and westslope cutthroat trout (Oncorhynchus clarki lewisi) populations. In 2007, the Kalispel Natural Resource Department (KNRD) initiated the Kalispel Nonnative Fish Suppression Project. The goal of this project is to implement actions to suppress or eradicate non-native fish in areas where native populations are declining or have been extirpated. These projects have previously been identified as critical to recovering native bull trout and westslope cutthroat trout (WCT). Lower Graham Creek was invaded by non-native rainbow (Oncorhynchus mykiss) and brook trout (Salvelinus fontinalis) after a small dam failed in 1991. By 2003, no genetically pure WCT remained in the lower 700 m of Graham Creek. Further invasion upstream is currently precluded by a relatively short section of steep, cascade-pool stepped channel section that will likely be breached in the near future. In 2008, a fish management structure (barrier) was constructed at the mouth of Graham Creek to preclude further invasion of non-native fish into Graham Creek. The construction of the barrier was preceded by intensive electrofishing in the lower 700 m to remove and relocate all captured fish. Westslope cutthroat trout have recently been extirpated in Cee Cee Ah Creek due to displacement by brook trout. We propose treating Cee Cee Ah Creek with a piscicide to eradicate brook trout. Once eradication is complete, cutthroat trout will be translocated from nearby watersheds. In 2004, the Washington Department of Fish and Wildlife (WDFW) proposed an antimycin treatment within the subbasin; the project encountered significant public opposition and was eventually abandoned. However, over the course of planning this 2004 project, little public involvement or education was conducted prior to the planned implementation. Therefore, in 2007 we implemented an extensive process to provide public education, address public concerns and provide opportunity for public involvement in implementing piscicides and other native fish recovery actions in the subbasin.

  2. Fate of Magnesium Chloride Brine Applied to Suppress Dust from Unpaved

    Office of Scientific and Technical Information (OSTI)

    Roads at the INEEL Subsurface Disposal Area (Journal Article) | SciTech Connect Fate of Magnesium Chloride Brine Applied to Suppress Dust from Unpaved Roads at the INEEL Subsurface Disposal Area Citation Details In-Document Search Title: Fate of Magnesium Chloride Brine Applied to Suppress Dust from Unpaved Roads at the INEEL Subsurface Disposal Area Between 1984 and 1993, MgCl2 brine was used to suppress dust on unpaved roads at a radioactive waste subsurface disposal area. Because Cl-

  3. Environmental factors affecting long-term stabilization of radon suppression covers for uranium mill tailings

    SciTech Connect (OSTI)

    Young, J.K.; Long, L.W.; Reis, J.W.

    1982-04-01

    Pacific Northwest Laboratory is investigating the use of a rock armoring blanket (riprap) to mitigate wind and water erosion of an earthen radon suppression cover applied to uranium mill tailings. To help determine design stresses for the tailings piles, environmental parameters are characterized for the five active uranium-producing regions on a site-specific basis. Only conventional uranium mills that are currently operating or that are scheduled to open in the mid 1980s are considered. Available data indicate that flooding has the most potential for disrupting a tailings pile. The arid regions of the Wyoming Basins and the Colorado Plateau are subject to brief storms of high intensity. The Texas Gulf Coast has the highest potential for extreme precipitation from hurricane-related storms. Wind data indicate average wind speeds from 3 to 6 m/sec for the sites, but extremes of 40 m/sec can be expected. Tornado risks range from low to moderate. The Colorado Plateau has the highest seismic potential, with maximum acceleration caused by earthquakes ranging from 0.2 to 0.4 g. Any direct effect from volcanic eruption is negligible, as all mills are located 90 km or more from an igneous or hydrothermal system.

  4. Intranuclear interactomic inhibition of NF-κB suppresses LPS-induced severe sepsis

    SciTech Connect (OSTI)

    Park, Sung-Dong; Cheon, So Yeong; Park, Tae-Yoon; Shin, Bo-Young; Oh, Hyunju; Ghosh, Sankar; Koo, Bon-Nyeo; Lee, Sang-Kyou

    2015-08-28

    Suppression of nuclear factor-κB (NF-κB) activation, which is best known as a major regulator of innate and adaptive immune responses, is a potent strategy for the treatment of endotoxic sepsis. To inhibit NF-κB functions, we designed the intra-nuclear transducible form of transcription modulation domain (TMD) of RelA (p65), called nt-p65-TMD, which can be delivered effectively into the nucleus without influencing the cell viability, and work as interactomic inhibitors via disruption of the endogenous p65-mediated transcription complex. nt-p65-TMD effectively inhibited the secretion of pro-inflammatory cytokines, including TNF-α, IL-1β, or IL-6 from BV2 microglia cells stimulated by lipopolysaccharide (LPS). nt-p65-TMD did not inhibit tyrosine phosphorylation of signaling mediators such as ZAP-70, p38, JNK, or ERK involved in T cell activation, but was capable of suppressing the transcriptional activity of NF-κB without the functional effect on that of NFAT upon T-cell receptor (TCR) stimulation. The transduced nt-p65-TMD in T cell did not affect the expression of CD69, however significantly inhibited the secretion of T cell-specific cytokines such as IL-2, IFN-γ, IL-4, IL-17A, or IL-10. Systemic administration of nt-p65-TMD showed a significant therapeutic effect on LPS-induced sepsis model by inhibiting pro-inflammatory cytokines secretion. Therefore, nt-p65-TMD can be a novel therapeutics for the treatment of various inflammatory diseases, including sepsis, where a transcription factor has a key role in pathogenesis, and further allows us to discover new functions of p65 under normal physiological condition without genetic alteration. - Highlights: • The nt-p65-TMD is intra-nuclear interactomic inhibitor of endogenous p65. • The nt-p65-TMD effectively inhibited the secretion of pro-inflammatory cytokines. • The excellent therapeutic potential of nt-p65-TMD was confirmed in sepsis model.

  5. Initial conditions dependency in heavy-quarks suppression in ultra-relativistic collisions

    SciTech Connect (OSTI)

    Alves Garcia Prado, Caio; Alarcon do Passo Suaide, Alexandre

    2013-05-06

    Heavy quark suppression in central Au+Au collisions is expected to be smaller than that of light quarks. However experimental data suggest that they are evenly suppressed. We propose considering fluctuations in the medium as they may lead to high-density regions which in turn can cause a considerable quark suppression at the early stages of the collision evolution. To analyse the overall effect of these fluctuations we perform computer simulations of charm and bottom propagating through the quark-gluon plasma and obtain estimates of the nuclear modification factor R{sub AA}. This quantity gives us information about the heavy quark suppression that can be compared to published experimental data from the STAR experiment.

  6. Experiments in sideband suppression on the Los Alamos National Laboratory Free-Electron Laser

    SciTech Connect (OSTI)

    White, C.J.; Coyle, M.R.; Paxton, A.H. (Mission Research Corp., Albuquerque, NM (United States). Laser and Optical R and D Group); O'Shea, P.G.; Bender, S.C.; Byrd, D.A.; Feldman, D.W.; Goldstein, J.C.: Pitcher, E.J.; Zaugg, T.J. (Los Alamos National Lab., NM (United States))

    1993-01-01

    Two versions of the Phase-Step Mirror'' (PSM), a novel optical component that prevents the formation of sidebands in a Free-Electron Laser (FEL) were tested on the Los Alamos National Laboratory (LANL) APEX FEL. Sideband suppression and frequency control with high extraction efficiency and single line, transform limited operation were demonstrated. The results of our LANL experiments and computer simulations showed that for very high gain applications, the first-order sideband is completely suppressed, but the laser gain is so strong that on about pass 300 the sideband at the second-order or next free spectral range of the PSM appears. This second-order sideband may be suppressed by designing a PSM with grooves having two alternating depths, one chosen to suppress the first-order sideband, and the other, the second-order sideband.

  7. Experiments in sideband suppression on the Los Alamos National Laboratory Free-Electron Laser

    SciTech Connect (OSTI)

    White, C.J.; Coyle, M.R.; Paxton, A.H. [Mission Research Corp., Albuquerque, NM (United States). Laser and Optical R and D Group; O`Shea, P.G.; Bender, S.C.; Byrd, D.A.; Feldman, D.W.; Goldstein, J.C.: Pitcher, E.J.; Zaugg, T.J. [Los Alamos National Lab., NM (United States)

    1993-06-01

    Two versions of the ``Phase-Step Mirror`` (PSM), a novel optical component that prevents the formation of sidebands in a Free-Electron Laser (FEL) were tested on the Los Alamos National Laboratory (LANL) APEX FEL. Sideband suppression and frequency control with high extraction efficiency and single line, transform limited operation were demonstrated. The results of our LANL experiments and computer simulations showed that for very high gain applications, the first-order sideband is completely suppressed, but the laser gain is so strong that on about pass 300 the sideband at the second-order or next free spectral range of the PSM appears. This second-order sideband may be suppressed by designing a PSM with grooves having two alternating depths, one chosen to suppress the first-order sideband, and the other, the second-order sideband.

  8. Method and system for suppression of stimulated Raman scattering in laser materials

    DOE Patents [OSTI]

    Caird, John A.; Bayramian, Andrew J.; Ebbers, Christopher A.

    2015-07-14

    A composition of matter is provided having the general chemical formula K(H,D).sub.2P(.sup.16O.sub.x,.sup.18O.sub.y).sub.4, where x<0.998 or y>0.002, and x+y.apprxeq.1. Additionally, a method of fabricating an optical material by growth from solution is provided. The method includes providing a solution including a predetermined percentage of (H,D).sub.2.sup.16O and a predetermined percentage of (H,D).sub.2.sup.18O, providing a seed crystal, and supporting the seed crystal on a platform. The method also includes immersing the seed crystal in the solution and forming the optical material. The optical material has the general chemical formula K(H,D).sub.2P(.sup.16O.sub.x,.sup.18O.sub.y).sub.4, where x<0.998 or y>0.002, and x+y.apprxeq.1.

  9. Method and system for suppression of stimulated Raman scattering in laser materials

    DOE Patents [OSTI]

    Caird, John A; Bayramian, Andrew J; Ebbers, Christopher A

    2013-11-19

    A composition of matter is provided having the general chemical formula K(H,D).sub.2P(.sup.16O.sub.x,.sup.18O.sub.y).sub.4, where x<0.998 or y>0.002, and x+y.apprxeq.1. Additionally, a method of fabricating an optical material by growth from solution is provided. The method includes providing a solution including a predetermined percentage of (H,D).sub.2.sup.16O and a predetermined percentage of (H,D).sub.2.sup.18O, providing a seed crystal, and supporting the seed crystal on a platform. The method also includes immersing the seed crystal in the solution and forming the optical material. The optical material has the general chemical formula K(H,D).sub.2P(.sup.16O.sub.x,.sup.18O.sub.y).sub.4, where x<0.998 or y>0.002, and x+y.apprxeq.1.

  10. Simulations of the electron cloud buildups and suppressions in Tevatron and

    Office of Scientific and Technical Information (OSTI)

    main injector (Conference) | SciTech Connect Simulations of the electron cloud buildups and suppressions in Tevatron and main injector Citation Details In-Document Search Title: Simulations of the electron cloud buildups and suppressions in Tevatron and main injector To assess the effects of the electron cloud on Main Injector intensity upgrades, simulations of the cloud buildup were carried out using POSINST and compared with ECLOUD. Results indicate that even assuming an optimistic 1.3

  11. Suppression of NF-κB signaling and NLRP3 inflammasome activation in

    Office of Scientific and Technical Information (OSTI)

    macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone (Journal Article) | SciTech Connect Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration of experimental murine colitis by the natural compound fraxinellone Citation Details In-Document Search Title: Suppression of NF-κB signaling and NLRP3 inflammasome activation in macrophages is responsible for the amelioration

  12. Gain media edge treatment to suppress amplified spontaneous emission in a high power laser

    DOE Patents [OSTI]

    Hackel, Lloyd A.; Soules, Thomas F.; Fochs, Scott N.; Rotter, Mark D.; Letts, Stephan A.

    2008-12-09

    A novel method and apparatus for suppressing ASE and parasitic oscillation modes in a high average power laser is introduced. By roughening one or more peripheral edges of a solid-state crystal or ceramic laser gain media and by bonding such edges using a substantially high index bonding elastomer or epoxy to a predetermined electromagnetic absorbing arranged adjacent to the entire outer surface of the peripheral edges of the roughened laser gain media, ASE and parasitic oscillation modes can be effectively suppressed.

  13. Gain media edge treatment to suppress amplified spontaneous emission in a high power laser

    DOE Patents [OSTI]

    Hackel, Lloyd A.; Soules, Thomas F.; Fochs, Scott N.; Rotter, Mark D.; Letts, Stephan A.

    2011-02-22

    A novel method and apparatus for suppressing ASE and/or parasitic oscillation modes in a laser is introduced. By roughening one or more peripheral edges of a solid-state crystal or ceramic laser gain media and by bonding such edges to a predetermined electromagnetic absorbing material arranged adjacent to the entire outer surface of the peripheral edges of the roughened laser gain media, ASE, parasitic oscillation modes and/or residual pump energy can be effectively suppressed.

  14. GNOSIS: THE FIRST INSTRUMENT TO USE FIBER BRAGG GRATINGS FOR OH SUPPRESSION

    SciTech Connect (OSTI)

    Trinh, Christopher Q.; Ellis, Simon C.; Bland-Hawthorn, Joss; Bryant, Julia; O'Byrne, John; Lawrence, Jon S.; Horton, Anthony J.; Shortridge, Keith; Case, Scott; Colless, Matthew; Gers, Luke; Lee, Steve; Miziarski, Stan; Leon-Saval, Sergio G.; Couch, Warrick; Glazebrook, Karl; Freeman, Kenneth; Loehmannsroeben, Hans-Gerd; and others

    2013-02-01

    The near-infrared is an important part of the spectrum in astronomy, especially in cosmology because the light from objects in the early universe is redshifted to these wavelengths. However, deep near-infrared observations are extremely difficult to make from ground-based telescopes due to the bright background from the atmosphere. Nearly all of this background comes from the bright and narrow emission lines of atmospheric hydroxyl (OH) molecules. The atmospheric background cannot be easily removed from data because the brightness fluctuates unpredictably on short timescales. The sensitivity of ground-based optical astronomy far exceeds that of near-infrared astronomy because of this long-standing problem. GNOSIS is a prototype astrophotonic instrument that utilizes 'OH suppression fibers' consisting of fiber Bragg gratings and photonic lanterns to suppress the 103 brightest atmospheric emission doublets between 1.47 and 1.7 {mu}m. GNOSIS was commissioned at the 3.9 m Anglo-Australian Telescope with the IRIS2 spectrograph to demonstrate the potential of OH suppression fibers, but may be potentially used with any telescope and spectrograph combination. Unlike previous atmospheric suppression techniques GNOSIS suppresses the lines before dispersion and in a manner that depends purely on wavelength. We present the instrument design and report the results of laboratory and on-sky tests from commissioning. While these tests demonstrated high throughput ( Almost-Equal-To 60%) and excellent suppression of the skylines by the OH suppression fibers, surprisingly GNOSIS produced no significant reduction in the interline background and the sensitivity of GNOSIS+IRIS2 is about the same as IRIS2. It is unclear whether the lack of reduction in the interline background is due to physical sources or systematic errors as the observations are detector noise dominated. OH suppression fibers could potentially impact ground-based astronomy at the level of adaptive optics or greater. However, until a clear reduction in the interline background and the corresponding increasing in sensitivity is demonstrated optimized OH suppression fibers paired with a fiber-fed spectrograph will at least provide a real benefit at low resolving powers.

  15. Tracking multiple generation and suppression of secondary electrons on periodic triangular surface

    SciTech Connect (OSTI)

    Li, S.; Wang, J. G.; Zhu, M.; Peng, J. C.; Xie, J. L.; Wu, X. L.; Guo, L. T.; Chang, C.; Xiong, Z. F.; Department of Engineering Physics, Tsinghua University, Beijing 10084

    2013-12-15

    To research the dynamic course of multipactor suppression on the periodically patterned surface, tens of electron collision processes are tracked by numerical calculation. The influences of microwave frequency, amplitude of RF electric field, slope angle, the local field enhancement, and the tilted incident electric field on the multipactor suppression are studied by tracking multi-generation electrons' trajectories, hopping and flight time, collision energy, and secondary emission yield. Meanwhile, the dynamic processes of secondary electrons on the periodic surface are analyzed by particle-in-cell (PIC) simulation. The PIC results are consistent with the analytical results in which the electrons fly reciprocatingly between the slopes and impact on the slopes; the methods of increasing the slope angle, enlarging the RF field, and lowering the frequency in a certain range are helpful to enhance the multipactor suppression steadily and persistently.

  16. A method for pressure-pulse suppression in fluid-filled piping

    SciTech Connect (OSTI)

    Shin, Y.W.; Bielick, E.F. ); Wiedermann, A.H. ); Ockert, C.E. )

    1990-01-01

    A simple, nondestructive method to suppress pressure pulses in fluid-filled piping was proposed and theoretically analyzed earlier. In this paper, the proposed method is verified experimentally. The results of experiments performed for the range of parameters of practical importance indicated that the attenuation of pressure pulses was in accordance with the theoretical predictions. This paper describes the experimental setup and the test models of the proposed pulse suppression devices and discusses the experimental results. In particular, the measured attenuation factors are presented and compared with the theoretical predictions. 8 refs., 17 figs., 2 tabs.

  17. A method for pressure-pulse suppression in fluid-filled piping

    SciTech Connect (OSTI)

    Shin, Y.W.; Bielick, E.F. ); Wiedermann, A.H. ); Ockert, C.E. )

    1989-01-01

    A simple, nondestructive method to suppress pressure pulses in fluid-filled piping was proposed and theoretically analyzed earlier. In this paper, the proposed method is verified experimentally. The results of experiments performed for the range of parameters of practical importance indicated that the attenuation of pressure pulses was in accordance with the theoretical predictions. This paper describes the experimental setup and the test models of the proposed pulse suppression devices and discusses the experimental results. In particular, the measured attenuation factors are presented and compared with the theoretical predictions. 8 ref., 17 fig., 2 tab.

  18. Suppression of n=1 Tilt Instability by Magnetic Shaping Coils in Rotamak Plasmas

    SciTech Connect (OSTI)

    Yang, X.; Petrov, Y.; Huang, T. S.

    2009-06-26

    Measurements from the array of Mirnov magnetic coils provide the first evidence for n=1 tilt and radial shift instabilities in a 40 ms field-reversed configuration (FRC) driven by rotating magnetic field. External plasma-shaping magnetic coils are utilized to suppress the n=1 instability modes. It is demonstrated that by energizing the middle shaping coil with 250-500 A current, the tilt mode is completely suppressed when a doublet FRC with an internal figure-of-eight separatrix is formed.

  19. The suppression effect of external magnetic field on the high-power microwave window multipactor phenomenon

    SciTech Connect (OSTI)

    Zhang, Xue Wang, Yong; Fan, Junjie

    2015-02-15

    To suppress the surface multipactor phenomenon and improve the transmitting power of the high-power microwave window, the application of external magnetic fields is theoretically analyzed and simulated. A Monte Carlo algorithm is used to track the secondary electron trajectories and study the multipactor scenario on the surface of a cylinder window. It is confirmed that over-resonant magnetic fields (an external magnetic field whose magnitude is slightly greater than that of a resonant magnetic field) will generate a compensating trajectory and collision, which can suppress the secondary electron avalanche. The optimal value of this external magnetic field that will avoid the multipactor phenomenon on cylinder windows is discussed.

  20. Suppress Carrier Recombination by Introducing Defects: The Case of Si Solar

    Office of Scientific and Technical Information (OSTI)

    Cell (Journal Article) | SciTech Connect Suppress Carrier Recombination by Introducing Defects: The Case of Si Solar Cell Citation Details In-Document Search Title: Suppress Carrier Recombination by Introducing Defects: The Case of Si Solar Cell Authors: Liu, Yuanyue ; Stradins, Paul ; Deng, Huixiong ; Luo, Junwei ; Wei, Su-Huai Publication Date: 2016-01-11 OSTI Identifier: 1236034 Report Number(s): NREL/JA-5J00-65690 Journal ID: ISSN 0003-6951 DOE Contract Number: AC36-08GO28308 Resource

  1. Suppression of the shear viscosity in a 'semi'-quark-gluon plasma (Journal

    Office of Scientific and Technical Information (OSTI)

    Article) | SciTech Connect Suppression of the shear viscosity in a 'semi'-quark-gluon plasma Citation Details In-Document Search Title: Suppression of the shear viscosity in a 'semi'-quark-gluon plasma We consider QCD at temperatures T near T{sub c}, where the theory deconfines. We distinguish between a 'complete' quark-gluon plasma (QGP), where the vacuum expectation value of the renormalized Polyakov loop is near unity, essentially constant with T, and the 'semi'-QGP, where the loop

  2. S4: A spatial-spectral model for speckle suppression

    SciTech Connect (OSTI)

    Fergus, Rob; Hogg, David W.; Oppenheimer, Rebecca; Brenner, Douglas; Pueyo, Laurent

    2014-10-20

    High dynamic range imagers aim to block or eliminate light from a very bright primary star in order to make it possible to detect and measure far fainter companions; in real systems, a small fraction of the primary light is scattered, diffracted, and unocculted. We introduce S4, a flexible data-driven model for the unocculted (and highly speckled) light in the P1640 spectroscopic coronagraph. The model uses principal components analysis (PCA) to capture the spatial structure and wavelength dependence of the speckles, but not the signal produced by any companion. Consequently, the residual typically includes the companion signal. The companion can thus be found by filtering this error signal with a fixed companion model. The approach is sensitive to companions that are of the order of a percent of the brightness of the speckles, or up to 10{sup 7} times the brightness of the primary star. This outperforms existing methods by a factor of two to three and is close to the shot-noise physical limit.

  3. Sirt2 suppresses inflammatory responses in collagen-induced arthritis

    SciTech Connect (OSTI)

    Lin, Jiangtao; Department of Orthopaedics, Yantaishan Hospital, 91 Jiefang Road, Yantai, Shandong 264001 ; Sun, Bing; Jiang, Chuanqiang; Hong, Huanyu; Zheng, Yanping

    2013-11-29

    Highlights: Sirt2 expression decreases in collagen-induced arthritis (CIA). Sirt2 knockout aggravates severity of arthritis in mice with CIA. Sirt2 knockout increases levels of pro-inflammatory factors in the serum. Sirt2 deacetylates p65 and inhibits pro-inflammatory factors expression. Sirt2 rescue abates severity of arthritis in mice with CIA. -- Abstract: Arthritis is a common autoimmune disease that is associated with progressive disability, systemic complications and early death. However, the underling mechanisms of arthritis are still unclear. Sirtuins are a NAD{sup +}-dependent class III deacetylase family, and regulate cellular stress, inflammation, genomic stability, carcinogenesis, and energy metabolism. Among the sirtuin family members, Sirt1 and Sirt6 are critically involved in the development of arthritis. It remains unknown whether other sirtuin family members participate in arthritis. Here in this study, we demonstrate that Sirt2 inhibits collagen-induced arthritis (CIA) using in vivo and in vitro evidence. The protein and mRNA levels of Sirt2 significantly decreased in joint tissues of mice with CIA. When immunized with collagen, Sirt2-KO mice showed aggravated severity of arthritis based on clinical scores, hind paw thickness, and radiological and molecular findings. Mechanically, Sirt2 deacetylated p65 subunit of nuclear factor-kappa B (NF-?B) at lysine 310, resulting in reduced expression of NF-?B-dependent genes, including interleukin 1? (IL-1?), IL-6, monocyte chemoattractant protein 1(MCP-1), RANTES, matrix metalloproteinase 9 (MMP-9) and MMP-13. Importantly, our rescue experiment showed that Sirt2 re-expression abated the severity of arthritis in Sirt2-KO mice. Those findings strongly indicate Sirt2 as a considerably inhibitor of the development of arthritis.

  4. WIND-DRIVEN ACCRETION IN PROTOPLANETARY DISKS. I. SUPPRESSION OF THE MAGNETOROTATIONAL INSTABILITY AND LAUNCHING OF THE MAGNETOCENTRIFUGAL WIND

    SciTech Connect (OSTI)

    Bai Xuening; Stone, James M., E-mail: xbai@cfa.harvard.edu [Department of Astrophysical Sciences, Peyton Hall, Princeton University, Princeton, NJ 08544 (United States)

    2013-05-20

    We perform local, vertically stratified shearing-box MHD simulations of protoplanetary disks (PPDs) at a fiducial radius of 1 AU that take into account the effects of both Ohmic resistivity and ambipolar diffusion (AD). The magnetic diffusion coefficients are evaluated self-consistently from a look-up table based on equilibrium chemistry. We first show that the inclusion of AD dramatically changes the conventional picture of layered accretion. Without net vertical magnetic field, the system evolves into a toroidal field dominated configuration with extremely weak turbulence in the far-UV ionization layer that is far too inefficient to drive rapid accretion. In the presence of a weak net vertical field (plasma {beta} {approx} 10{sup 5} at midplane), we find that the magnetorotational instability (MRI) is completely suppressed, resulting in a fully laminar flow throughout the vertical extent of the disk. A strong magnetocentrifugal wind is launched that efficiently carries away disk angular momentum and easily accounts for the observed accretion rate in PPDs. Moreover, under a physical disk wind geometry, all the accretion flow proceeds through a strong current layer with a thickness of {approx}0.3H that is offset from disk midplane with radial velocity of up to 0.4 times the sound speed. Both Ohmic resistivity and AD are essential for the suppression of the MRI and wind launching. The efficiency of wind transport increases with increasing net vertical magnetic flux and the penetration depth of the FUV ionization. Our laminar wind solution has important implications on planet formation and global evolution of PPDs.

  5. The Use of Oil Refinery Wastes as a Dust Suppression Surfactant for Use in Mining

    SciTech Connect (OSTI)

    Dixon-Hardy, D.W.; Beyhan, S.; Ediz, I.G.; Erarslan, K.

    2008-10-15

    In this research, the suitability of a selection of petroleum refinery wastes as a dust suppressant were examined. Dust is a significant problem in surface and underground mining mainly because of its adverse effects on human health and machinery. Hence, dust control and suppression is a vital part of mine planning for mining engineers. Water is the oldest and the cheapest suppressant in dealing with the mine dusts. However, surfactant use has recently been used for a wider range of applications in the mining industry. In order to carry out laboratory experiments, a dust chamber was designed and manufactured. The chamber has an inlet for coal dust entrance and a nozzle for spraying water and the oil refinery wastes. Water and the surfactants were mixed at various ratios and then sprayed onto the coal dusts within the cell. Dust concentration was measured systematically to determine the effects of surfactant containing solution on the coal dust and the data obtained by the measurements were analyzed. The results showed that the oil refinery wastes could be used as a dust suppressant, which may create an economical utilization for the wastes concerned.

  6. Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes

    SciTech Connect (OSTI)

    Chen, Yanyan; Xue, Peng; Hou, Yongyong; Zhang, Hao; Zheng, Hongzhi; Zhou, Tong; Qu, Weidong; Teng, Weiping; Zhang, Qiang; Andersen, Melvin E.; Pi, Jingbo

    2013-12-15

    Transcriptional signaling through the antioxidant response element (ARE), orchestrated by the Nuclear factor E2-related factor 2 (Nrf2), is a major cellular defense mechanism against oxidative or electrophilic stress. Here, we reported that isoniazid (INH), a widely used antitubercular drug, displays a substantial inhibitory property against ARE activities in diverse mouse and human cells. In 3T3-L1 preadipocytes, INH concentration-dependently suppressed the ARE-luciferase reporter activity and mRNA expression of various ARE-dependent antioxidant genes under basal and oxidative stressed conditions. In keeping with our previous findings that Nrf2-ARE plays a critical role in adipogenesis by regulating expression of CCAAT/enhancer-binding protein ? (C/EBP?) and peroxisome proliferator-activated receptor ? (PPAR?), suppression of ARE signaling by INH hampered adipogenic differentiation of 3T3-L1 cells and human adipose-derived stem cells (ADSCs). Following adipogenesis induced by hormonal cocktails, INH-treated 3T3-L1 cells and ADSCs displayed significantly reduced levels of lipid accumulation and attenuated expression of C/EBP? and PPAR?. Time-course studies in 3T3-L1 cells revealed that inhibition of adipogenesis by INH occurred in the early stage of terminal adipogenic differentiation, where reduced expression of C/EBP? and C/EBP? was observed. To our knowledge, the present study is the first to demonstrate that INH suppresses ARE signaling and interrupts with the transcriptional network of adipogenesis, leading to impaired adipogenic differentiation. The inhibition of ARE signaling may be a potential underlying mechanism by which INH attenuates cellular antioxidant response contributing to various complications. - Highlights: Isoniazid suppresses ARE-mediated transcriptional activity. Isoniazid inhibits adipogenesis in preadipocytes. Isoniazid suppresses adipogenic gene expression during adipogenesis.

  7. Novel Americium Treatment Process for Surface Water and Dust Suppression Water

    SciTech Connect (OSTI)

    Tiepel, E.W.; Pigeon, P.; Nesta, S.; Anderson, J.

    2006-07-01

    The Rocky Flats Environmental Technology Site (RFETS), a former nuclear weapons production plant, has been remediated under CERCLA and decommissioned to become a National Wildlife Refuge. The site conducted this cleanup effort under the Rocky Flats Cleanup Agreement (RFCA) that established limits for the discharge of surface and process waters from the site. At the end of 2004, while a number of process buildings were undergoing decommissioning, routine monitoring of a discharge pond (Pond A-4) containing approximately 28 million gallons of water was discovered to have been contaminated with a trace amount of Americium-241 (Am-241). While the amount of Am-241 in the pond waters was very low (0.5 - 0.7 pCi/l), it was above the established Colorado stream standard of 0.15 pCi/l for release to off site drainage waters. The rapid successful treatment of these waters to the regulatory limit was important to the site for two reasons. The first was that the pond was approaching its hold-up limit. Without rapid treatment and release of the Pond A-4 water, typical spring run-off would require water management actions to other drainages onsite or a mass shuttling of water for disposal. The second reason was that this type of contaminated water had not been treated to the stringent stream standard at Rocky Flats before. Technical challenges in treatment could translate to impacts on water and secondary waste management, and ultimately, cost impacts. All of the technical challenges and specific site criteria led to the conclusion that a different approach to the treatment of this problem was necessary and a crash treatability program to identify applicable treatment techniques was undertaken. The goal of this program was to develop treatment options that could be implemented very quickly and would result in the generation of no high volume secondary waste that would be costly to dispose. A novel chemical treatment system was developed and implemented at the RFETS to treat Am-241 contaminated pond water, surface run-off and D and D dust suppression water during the later stages of the D and D effort at Rocky Flats. This novel chemical treatment system allowed for highly efficient, high-volume treatment of all contaminated waste waters to the very low stream standard of 0.15 pCi/1 with strict compliance to the RFCA discharge criteria for release to off-site surface waters. The rapid development and implementation of the treatment system avoided water management issues that would have had to be addressed if contaminated water had remained in Pond A-4 into the Spring of 2005. Implementation of this treatment system for the Pond A-4 waters and the D and D waters from Buildings 776 and 371 enabled the site to achieve cost-effective treatment that minimized secondary waste generation, avoiding the need for expensive off-site water disposal. Water treatment was conducted for a cost of less than $0.20/gal which included all development costs, capital costs and operational costs. This innovative and rapid response effort saved the RFETS cleanup program well in excess of $30 million for the potential cost of off-site transportation and treatment of radioactive liquid waste. (authors)

  8. High power laser perforating tools and systems

    DOE Patents [OSTI]

    Zediker, Mark S; Rinzler, Charles C; Faircloth, Brian O; Koblick, Yeshaya; Moxley, Joel F

    2014-04-22

    ystems devices and methods for the transmission of 1 kW or more of laser energy deep into the earth and for the suppression of associated nonlinear phenomena. Systems, devices and methods for the laser perforation of a borehole in the earth. These systems can deliver high power laser energy down a deep borehole, while maintaining the high power to perforate such boreholes.

  9. Low concentrations of bisphenol a suppress thyroid hormone receptor transcription through a nongenomic mechanism

    SciTech Connect (OSTI)

    Sheng, Zhi-Guo; Tang, Yuan; Liu, Yu-Xiang; Yuan, Ye; Zhao, Bao-Quan; Chao, Xi-Juan; Zhu, Ben-Zhan

    2012-02-15

    Bisphenol (BPA) is one of the highest-volume chemicals produced worldwide, and human exposure to BPA is thought to be ubiquitous. Various rodent and in vitro studies have shown that thyroid hormone (TH) function can be impaired by BPA. However, it is still unknown if low concentrations of BPA can suppress the thyroid hormone receptor (TR) transcription. The present study aims to investigate the possible suppressing effects of low concentrations of BPA on TR transcription and the involved mechanism(s) in CV-1 cells derived from cercopithecus aethiops monkey kidneys. Using gene reporter assays, BPA at concentrations as low as 10{sup ?9} M suppresses TR or steroid receptor coactivator-1(SRC-1)-enhanced TR transcription, but not reducing TR/SRC-1 interaction in mammalian two-hybrid and glutathione S-transferase pull-down studies. It has been further shown that both nuclear receptor co-repressor (N-CoR) and silencing mediator for retinoid and thyroid hormone receptors (SMRT) are recruited to the TR-?1 by BPA in the presence of physiologic concentrations of T3 or T4. However, the overexpression of ?3 integrin or c-Src significantly reduces BPA-induced recruitment of N-CoR/SMRT to TR or suppression of TR transcription. Furthermore, BPA inhibits the T3/T4-mediated interassociation of the ?3 integrin/c-Src/MAPK/TR-?1 pathways by the co-immunoprecipitation. These results indicate that low concentrations of BPA suppress the TR transcription by disrupting physiologic concentrations of T3/T4-mediated ?3 integrin/c-Src/MAPK/TR-?1 pathways, followed by recruiting N-CoR/SMRT to TR-?1, providing a novel insight regarding the TH disruption effects of low concentration BPA. -- Highlights: ? Environmentally relevant concentrations of BPA suppress TR transcription. ? BPA recruits the N-CoR/SMRT to TR under the physiologic concentrations of T3/T4. ? BPA disrupts T3/T4-mediated ?3 integrin/c-Src/MAPK/TR-?1 pathways.

  10. SURFACE FILMS TO SUPPRESS FIELD EMISSION IN HIGH-POWER MICROWAVE COMPONENTS

    SciTech Connect (OSTI)

    Hirshfield, Jay l

    2014-02-07

    Results are reported on attempts to reduce the RF breakdown probability on copper accelerator structures by applying thin surface films that could suppress field emission of electrons. Techniques for application and testing of copper samples with films of metals with work functions higher than copper are described, principally for application of platinum films, since platinum has the second highest work function of any metal. Techniques for application of insulating films are also described, since these can suppress field emission and damage on account of dielectric shielding of fields at the copper surface, and on account of the greater hardness of insulating films, as compared with copper. In particular, application of zirconium oxide films on high-field portions of a 11.424 GHz SLAC cavity structure for breakdown tests are described.

  11. Alternative approach for fire suppression of class A, B and C fires in gloveboxes

    SciTech Connect (OSTI)

    Rosenberger, Mark S; Tsiagkouris, James A

    2011-02-10

    Department of Energy (DOE) Orders and National Fire Protection Association (NFPA) Codes and Standards require fire suppression in gloveboxes. Several potential solutions have been and are currently being considered at Los Alamos National Laboratory (LANL). The objective is to provide reliable, minimally invasive, and seismically robust fire suppression capable of extinguishing Class A, B, and C fires; achieve compliance with DOE and NFPA requirements; and provide value-added improvements to fire safety in gloveboxes. This report provides a brief summary of current approaches and also documents the successful fire tests conducted to prove that one approach, specifically Fire Foe{trademark} tubes, is capable of achieving the requirement to provide reliable fire protection in gloveboxes in a cost-effective manner.

  12. An ion guide laser ion source for isobar-suppressed rare isotope beams

    SciTech Connect (OSTI)

    Raeder, Sebastian Ames, Friedhelm; Bishop, Daryl; Bricault, Pierre; Kunz, Peter; Mjs, Anders; Heggen, Henning; Institute of Applied Physics, TU Darmstadt, Schlossgartenstr. 7, 64289 Darmstadt ; Lassen, Jens Teigelhfer, Andrea; Department of Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba R3T 2N2

    2014-03-15

    Modern experiments at isotope separator on-line (ISOL) facilities like ISAC at TRIUMF often depend critically on the purity of the delivered rare isotope beams. Therefore, highly selective ion sources are essential. This article presents the development and successful on-line operation of an ion guide laser ion source (IG-LIS) for the production of ion beams free of isobaric contamination. Thermionic ions from the hot ISOL target are suppressed by an electrostatic potential barrier, while neutral radio nuclides effusing out are resonantly ionized by laser radiation within a quadrupole ion guide behind this barrier. The IG-LIS was developed through detailed thermal and ion optics simulation studies and off-line tests with stable isotopes. In a first on-line run with a SiC target a suppression of surface-ionized Na contaminants in the ion beam of up to six orders of magnitude was demonstrated.

  13. Protein A suppresses immune responses during Staphylococcus aureus bloodstream infection in guinea pigs

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Kim, Hwan Keun; Falugi, Fabiana; Thomer, Lena; Missiakas, Dominique M.; Schneewind, Olaf

    2015-01-06

    Staphylococcus aureus infection is not associated with the development of protective immunity, and disease relapses occur frequently. We hypothesize that protein A, a factor that binds immunoglobulin Fcγ and cross-links VH3 clan B cell receptors (IgM), is the staphylococcal determinant for host immune suppression. To test this, vertebrate IgM was examined for protein A cross-linking. High VH3 binding activity occurred with human and guinea immunoglobulin, whereas mouse and rabbit immunoglobulins displayed little and no binding, respectively. Establishing a guinea pig model of S. aureus bloodstream infection, we show that protein A functions as a virulence determinant and suppresses host Bmore » cell responses. Immunization with SpAKKAA, which cannot bind immunoglobulin, elicits neutralizing antibodies that enable guinea pigs to develop protective immunity.« less

  14. Strong far-infrared cooling lines, peculiar CO kinematics, and possible star-formation suppression in Hickson compact group 57

    SciTech Connect (OSTI)

    Alatalo, K.; Appleton, P. N.; Ogle, P. M.; Rich, J. A.; Xu, C. K.; Lisenfeld, U.; Bitsakis, T.; Guillard, P.; Charmandaris, V.; Cluver, M.; Jarrett, T.; Dopita, M. A.; Kewley, L. J.; Freeland, E.; Rasmussen, J.; Verdes-Montenegro, L.

    2014-11-10

    We present [C II] and [O I] observations from Herschel and CO(1-0) maps from the Combined Array for Research in Millimeter Astronomy (CARMA) of the Hickson compact group HCG 57, focusing on the galaxies HCG 57a and HCG 57d. HCG 57a has been previously shown to contain enhanced quantities of warm molecular hydrogen consistent with shock or turbulent heating. Our observations show that HCG 57d has strong [C II] emission compared to L {sub FIR} and weak CO(1-0), while in HCG 57a, both the [C II] and CO(1-0) are strong. HCG 57a lies at the upper end of the normal distribution of the [C II]/CO and [C II]/FIR ratios, and its far-infrared (FIR) cooling supports a low-density, warm, diffuse gas that falls close to the boundary of acceptable models of a photon-dominated region. However, the power radiated in the [C II] and warm H{sub 2} emissions have similar magnitudes, as seen in other shock-dominated systems and predicted by recent models. We suggest that shock heating of the [C II] is a viable alternative to photoelectric heating in violently disturbed, diffuse gas. The existence of shocks is also consistent with the peculiar CO kinematics in the galaxy, indicating that highly noncircular motions are present. These kinematically disturbed CO regions also show evidence of suppressed star formation, falling a factor of 10-30 below normal galaxies on the Kennicutt-Schmidt relation. We suggest that the peculiar properties of both galaxies are consistent with a highly dissipative, off-center collisional encounter between HCG 57d and 57a, creating ring-like morphologies in both systems. Highly dissipative gas-on-gas collisions may be more common in dense groups because of the likelihood of repeated multiple encounters. The possibility of shock-induced star-formation suppression may explain why a subset of these HCG galaxies has been found previously to fall in the mid-infrared green valley.

  15. Impaired methylation as a novel mechanism for proteasome suppression in liver cells

    SciTech Connect (OSTI)

    Osna, Natalia A.; White, Ronda L.; Donohue, Terrence M.; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105 ; Beard, Michael R.; Tuma, Dean J.; Kharbanda, Kusum K.; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105

    2010-01-08

    The proteasome is a multi-catalytic protein degradation enzyme that is regulated by ethanol-induced oxidative stress; such suppression is attributed to CYP2E1-generated metabolites. However, under certain conditions, it appears that in addition to oxidative stress, other mechanisms are also involved in proteasome regulation. This study investigated whether impaired protein methylation that occurs during exposure of liver cells to ethanol, may contribute to suppression of proteasome activity. We measured the chymotrypsin-like proteasome activity in Huh7CYP cells, hepatocytes, liver cytosols and nuclear extracts or purified 20S proteasome under conditions that maintain or prevent protein methylation. Reduction of proteasome activity of hepatoma cell and hepatocytes by ethanol or tubercidin was prevented by simultaneous treatment with S-adenosylmethionine (SAM). Moreover, the tubercidin-induced decline in proteasome activity occurred in both nuclear and cytosolic fractions. In vitro exposure of cell cytosolic fractions or highly purified 20S proteasome to low SAM:S-adenosylhomocysteine (SAH) ratios in the buffer also suppressed proteasome function, indicating that one or more methyltransferase(s) may be associated with proteasomal subunits. Immunoblotting a purified 20S rabbit red cell proteasome preparation using methyl lysine-specific antibodies revealed a 25 kDa proteasome subunit that showed positive reactivity with anti-methyl lysine. This reactivity was modified when 20S proteasome was exposed to differential SAM:SAH ratios. We conclude that impaired methylation of proteasome subunits suppressed proteasome activity in liver cells indicating an additional, yet novel mechanism of proteasome activity regulation by ethanol.

  16. Schisantherin A suppresses osteoclast formation and wear particle-induced osteolysis via modulating RANKL signaling pathways

    SciTech Connect (OSTI)

    He, Yi; Zhang, Qing; Shen, Yi; Chen, Xia; Zhou, Feng; Peng, Dan

    2014-07-04

    Highlights: • Schisantherin A suppresses osteoclasts formation and function in vitro. • Schisantherin A impairs RANKL signaling pathway. • Schisantherin A suppresses osteolysis in vivo. • Schisantherin A may be used for treating osteoclast related diseases. - Abstract: Receptor activator of NF-κB ligand (RANKL) plays critical role in osteoclastogenesis. Targeting RANKL signaling pathways has been a promising strategy for treating osteoclast related bone diseases such as osteoporosis and aseptic prosthetic loosening. Schisantherin A (SA), a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent, but its effect on osteoclasts has been hitherto unknown. In the present study, SA was found to inhibit RANKL-induced osteoclast formation and bone resorption. The osteoclastic specific marker genes induced by RANKL including c-Src, SA inhibited OSCAR, cathepsin K and TRAP in a dose dependent manner. Further signal transduction studies revealed that SA down-regulate RANKL-induced nuclear factor-kappaB (NF-κB) signaling activation by suppressing the phosphorylation and degradation of IκBα, and subsequently preventing the NF-κB transcriptional activity. Moreover, SA also decreased the RANKL-induced MAPKs signaling pathway, including JNK and ERK1/2 posphorylation while had no obvious effects on p38 activation. Finally, SA suppressed the NF-κB and MAPKs subsequent gene expression of NFATc1 and c-Fos. In vivo studies, SA inhibited osteoclast function and exhibited bone protection effect in wear-particle-induced bone erosion model. Taken together, SA could attenuate osteoclast formation and wear particle-induced osteolysis by mediating RANKL signaling pathways. These data indicated that SA is a promising therapeutic natural compound for the treatment of osteoclast-related prosthesis loosening.

  17. Suppression of Tin Whiskers in Lead-Free Solder - Energy Innovation Portal

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Suppression of Tin Whiskers in Lead-Free Solder Improved electronics reliability by surpressing whiskers that can cause short circuits and arcing in electrical circuits Savannah River National Laboratory Contact SRNL About This Technology Technology Marketing Summary Scientists at the Savannah River National Laboratory have identified a treatment method that slows or prevents the formation of whiskers in lead-free solder. The current stage of research has shown initial time studies in comparison

  18. MicroRNA-340 suppresses osteosarcoma tumor growth and metastasis by directly targeting ROCK1

    SciTech Connect (OSTI)

    Zhou, Xin; Wei, Min; Wang, Wei

    2013-08-09

    Highlights: •miR-340 is downregulated in OS cell lines and tissues. •miR-340 suppresses OS cell proliferation, migration and invasion. •miR-340 suppresses tumor growth and metastasis of OS cells in nude mice. •ROCK1 is a target gene of miR-340. •ROCK1 is involved in miR-340-induced suppression of OS cell proliferation, migration and invasion. -- Abstract: MicroRNAs (miRNAs) play key roles in cancer development and progression. In the present study, we investigated the role of miR-340 in the progression and metastasis of osteosarcoma (OS). Our results showed that miR-340 was frequently downregulated in OS tumors and cell lines. Overexpression of miR-340 in OS cell lines significantly inhibited cell proliferation, migration, and invasion in vitro, and tumor growth and metastasis in a xenograft mouse model. ROCK1 was identified as a target of miR-340, and ectopic expression of miR-340 downregulated ROCK1 by direct binding to its 3′ untranslated region. siRNA-mediated silencing of ROCK1 phenocopied the effects of miR-340 overexpression, whereas restoration of ROCK1 in miR-340-overexpressing OS cells reversed the suppressive effects of miR-340. Together, these findings indicate that miR-340 acts as a tumor suppressor and its downregulation in tumor tissues may contribute to the progression and metastasis of OS through a mechanism involving ROCK1, suggesting miR-340 as a potential new diagnostic and therapeutic target for the treatment of OS.

  19. Observation of Shot Noise Suppression at Optical Wavelengths in a Relativistic Electron Beam

    SciTech Connect (OSTI)

    Ratner, Daniel; Stupakov, Gennady; /SLAC

    2012-06-19

    Control of collective properties of relativistic particles is increasingly important in modern accelerators. In particular, shot noise affects accelerator performance by driving instabilities or by competing with coherent processes. We present experimental observations of shot noise suppression in a relativistic beam at the Linac Coherent Light Source. By adjusting the dispersive strength of a chicane, we observe a decrease in the optical transition radiation emitted from a downstream foil. We show agreement between the experimental results, theoretical models, and 3D particle simulations.

  20. The effect of periodic wavy profile on suppressing window multipactor under arbitrary electromagnetic mode

    SciTech Connect (OSTI)

    Chang, C.; Liu, Y. S.; Chen, C. H.; Guo, L. T.; Li, S.; Wu, X. L.; Verboncoeur, J.

    2015-01-05

    The three-dimensional periodic ripple profile with each unit of rotational symmetric surface is proposed to suppress multipactor for arbitrary electromagnetic mode with any polarization. The field distribution and multipactor electron dynamics on the wavy surface are studied to illustrate the multipactor inhibition mechanism. High power microwave experiment was conducted to demonstrate the effect of wavy surface on significantly improving the window power capacity.

  1. Suppressing Manganese Dissolution from Lithium Manganese Oxide Spinel Cathodes with Single-Layer Graphene

    SciTech Connect (OSTI)

    Jaber-Ansari, Laila; Puntambekar, Kanan P.; Kim, Soo; Aykol, Muratahan; Luo, Langli; Wu, Jinsong; Myers, Benjamin D.; Iddir, Hakim; Russell, John T.; Saldana, Spencer J.; Kumar, Rajan; Thackeray, Michael M.; Curtiss, Larry A.; Dravid, Vinayak P.; Wolverton, Christopher M.; Hersam, Mark C.

    2015-06-24

    Spinel-structured LiMn 2 O 4 (LMO) is a desirable cathode material for Li-ion batteries due to its low cost, abundance, and high power capability. However, LMO suffers from limited cycle life that is triggered by manganese dissolution into the electrolyte during electrochemical cycling. Here, it is shown that single-layer graphene coatings suppress manganese dissolution, thus enhancing the performance and lifetime of LMO cathodes. Relative to lithium cells with uncoated LMO cathodes, cells with graphene-coated LMO cathodes provide improved capacity retention with enhanced cycling stability. X-ray photoelectron spectroscopy reveals that graphene coatings inhibit manganese depletion from the LMO surface. Additionally, transmission electron microscopy demonstrates that a stable solid electrolyte interphase is formed on graphene, which screens the LMO from direct contact with the electrolyte. Density functional theory calculations provide two mechanisms for the role of graphene in the suppression of manganese dissolution. First, common defects in single-layer graphene are found to allow the transport of lithium while concurrently acting as barriers for manganese diffusion. Second, graphene can chemically interact with Mn 3+ at the LMO electrode surface, promoting an oxidation state change to Mn 4+ , which suppresses dissolution.

  2. Knockdown of p53 suppresses Nanog expression in embryonic stem cells

    SciTech Connect (OSTI)

    Abdelalim, Essam Mohamed; Tooyama, Ikuo

    2014-01-10

    Highlights: We investigate the role of p53 in ESCs in the absence of DNA damage. p53 knockdown suppresses ESC proliferation. p53 knockdown downregulates Nanog expression. p53 is essential for mouse ESC self-renewal. -- Abstract: Mouse embryonic stem cells (ESCs) express high levels of cytoplasmic p53. Exposure of mouse ESCs to DNA damage leads to activation of p53, inducing Nanog suppression. In contrast to earlier studies, we recently reported that chemical inhibition of p53 suppresses ESC proliferation. Here, we confirm that p53 signaling is involved in the maintenance of mouse ESC self-renewal. RNA interference-mediated knockdown of p53 induced downregulation of p21 and defects in ESC proliferation. Furthermore, p53 knockdown resulted in a significant downregulation in Nanog expression at 24 and 48 h post-transfection. p53 knockdown also caused a reduction in Oct4 expression at 48 h post-transfection. Conversely, exposure of ESCs to DNA damage caused a higher reduction of Nanog expression in control siRNA-treated cells than in p53 siRNA-treated cells. These data show that in the absence of DNA damage, p53 is required for the maintenance of mouse ESC self-renewal by regulating Nanog expression.

  3. miR-17 inhibitor suppressed osteosarcoma tumor growth and metastasis via increasing PTEN expression

    SciTech Connect (OSTI)

    Gao, Yong; Luo, Ling-hui; Li, Shuai; Yang, Cao

    2014-02-07

    Highlights: • miR-17 was increased in OS tissues and cell lines. • Inhibition of miR-17 suppressed OS cell proliferation. • Inhibition of miR-17 suppressed OS cell migration and invasion. • PTEN was a target of miR-17. • miR-17 was negatively correlated with PTEN in OS tissues. - Abstract: MicroRNAs (miRNAs) play essential roles in cancer development and progression. Here, we investigated the role of miR-17 in the progression and metastasis of osteosarcoma (OS). miR-17 was frequently increased in OS tissues and cell lines. Inhibition of miR-17 in OS cell lines substantially suppressed cell proliferation, migration, and invasion. Phosphatase and tensin homolog (PTEN) was identified as a target of miR-17, and ectopic expression of miR-17 inhibited PTEN by direct binding to its 3′-untranslated region (3′-UTR). Expression of miR-17 was negatively correlated with PTEN in OS tissues. Together, these findings indicate that miR-17 acts as an oncogenic miRNA and may contribute to the progression and metastasis of OS, suggesting miR-17 as a potential novel diagnostic and therapeutic target of OS.

  4. Advances in the Understanding of ELM Suppression by Resonant Magnetic Perturbations (RMPs) in DIII-D and Implications for ITER

    SciTech Connect (OSTI)

    Nazikian, R.

    2014-09-01

    Experiments on DIII-D have expanding the operating window for RMP ELM suppression to higher q95 with dominant electron heating and fully non-inductive current drive relevant to advanced modes of ITER operation. Robust ELM suppression has also been obtained with a reduced coil set, mitigating the risk of coil failure in maintaining ELM suppression in ITER. These results significantly expand the operating space and reduce risk for obtaining RMP ELM suppression in ITER. Efforts have also been made to search for 3D cause of ELM suppression. No internal non-axisymmetric structure is detected at the top of the pedestal, indicating that the dominant effect of the RMP is to produce an n=0 transport modification of the profiles. Linear two fluid MHD simulations using M3D-C1 indicate resonant field penetration and significant magnetic stochasticity at the top of the pedestal, consistent with the absence of detectable 3D structure in that region. A profile database was developed to compare the scaling of the pedestal and global confinement with the applied 3D field strength in ELM suppressed and ELM mitigated plasmas. The EPED pedestal model accurately predicts the measured pedestal pressure at the threshold of ELM suppression, increasing confidence in theoretical projections to ITER pedestal conditions. Both the H-factor (H(sub)98y2) and thermal energy confinement time do not degrade substantially with applied RMP fields near the threshold of ELM suppression, enhancing confidence in the compatibility of ITER high performance operation with RMP ELM suppression.

  5. RapTOR: Automated sequencing library preparation and suppression for rapid pathogen characterization ( 7th Annual SFAF Meeting, 2012)

    ScienceCinema (OSTI)

    Lane, Todd [SNL

    2013-02-11

    Todd Lane on "RapTOR: Automated sequencing library preparation and suppression for rapid pathogen characterization" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

  6. An assessment of alternatives and technologies for replacing ozone- depleting substances at DOE facilities

    SciTech Connect (OSTI)

    Purcell, C.W.; Miller, K.B.; Friedman, J.R.; Rapoport, R.D.; Conover, D.R.; Hendrickson, P.L.; Koss, T.C.

    1992-10-01

    Title VI of the Clean Air Act, as amended, mandates a production phase-out for ozone-depleting substances (ODSs). These requirements will have a significant impact on US Department of Energy (DOE) facilities. Currently, DOE uses ODSs in three major activities: fire suppression (halon), refrigeration and cooling (chlorofluorocarbons [CFCs]), and cleaning that requires solvents (CFCs, methyl chloroform, and carbon tetrachloride). This report provides basic information on methods and strategies to phase out use of ODSs at DOE facilities.

  7. p53 Mutation suppresses adult neurogenesis in medaka fish (Oryzias latipes)

    SciTech Connect (OSTI)

    Isoe, Yasuko; Okuyama, Teruhiro; Taniguchi, Yoshihito; Kubo, Takeo; Takeuchi, Hideaki

    2012-07-13

    Highlights: Black-Right-Pointing-Pointer Progenitor migration is accompanied by an increase in their numbers in the adult brain. Black-Right-Pointing-Pointer p53 Mutation suppressed an increase in the number of the migrated progenitors. Black-Right-Pointing-Pointer The decreased progenitor number is not due to enhanced cell death. Black-Right-Pointing-Pointer p53 Mutation did not affect proliferation of stem cells. -- Abstract: Tumor suppressor p53 negatively regulates self-renewal of neural stem cells in the adult murine brain. Here, we report that the p53 null mutation in medaka fish (Oryzias latipes) suppressed neurogenesis in the telencephalon, independent of cell death. By using 5-bromo-29-deoxyuridine (BrdU) immunohistochemistry, we identified 18 proliferation zones in the brains of young medaka fish; in situ hybridization showed that p53 was expressed selectively in at least 12 proliferation zones. We also compared the number of BrdU-positive cells present in the whole telencephalon of wild-type (WT) and p53 mutant fish. Immediately after BrdU exposure, the number of BrdU-positive cells did not differ significantly between them. One week after BrdU-exposure, the BrdU-positive cells migrated from the proliferation zone, which was accompanied by an increased number in the WT brain. In contrast, no significant increase was observed in the p53 mutant brain. Terminal deoxynucleotidyl transferase (dUTP) nick end-labeling revealed that there was no significant difference in the number of apoptotic cells in the telencephalon of p53 mutant and WT medaka, suggesting that the decreased number of BrdU-positive cells in the mutant may be due to the suppression of proliferation rather than the enhancement of neural cell death. These results suggest that p53 positively regulates neurogenesis via cell proliferation.

  8. Speckle noise suppression using a helix-free ferroelectric liquid crystal cell

    SciTech Connect (OSTI)

    Andreev, A L; Andreeva, T B; Kompanets, I N; Zalyapin, N V

    2014-12-31

    We have studied the method for suppressing speckle noise in patterns produced by a laser based on a fast-response electro-optical cell with a ferroelectric liquid crystal (FLC) in which helicoid is absent, i.e., compensated for. The character of smectic layer deformation in an electric field is considered along with the mechanism of spatially inhomogeneous phase modulation of a laser beam passing through the cell which is accompanied by the destruction of phase relations in the beam. Advantages of a helix-free FLC cell are pointed out as compared to helical crystal cells studied previously. (liquid crystal devices)

  9. Empirical Study Of Tube Wave Suppression For Single Well Seismic Imaging

    SciTech Connect (OSTI)

    West, Phillip Bradley; Weinberg, David Michael; Fincke, James Russell

    2002-05-01

    This report addresses the Idaho National Engineering and Environmental Laboratory's portion of a collaborative effort with Lawrence Berkeley National Laboratory and Sandia National Laboratories on a borehole seismic project called Single Well Seismic Imaging. The INEEL's role was to design, fabricate, deploy, and test a number of passive devices to suppress the energy within the borehole. This energy is generally known as tube waves. Heretofore, tube waves precluded acquisition of meaningful single-well seismic data. This report addresses the INEEL tests, theories, observations, and test results.

  10. Empirical Study Of Tube Wave Suppression For Single Well Seismic Imaging

    SciTech Connect (OSTI)

    West, P.B.; Weinberg, D.M.; Fincke, J.R.

    2002-05-31

    This report addresses the Idaho National Engineering and Environmental Laboratory's portion of a collaborative effort with Lawrence Berkeley National Laboratory and Sandia National Laboratories on a borehole seismic project called Single Well Seismic Imaging. The INEEL's role was to design, fabricate, deploy, and test a number of passive devices to suppress the energy within the borehole. This energy is generally known as tube waves. Heretofore, tube waves precluded acquisition of meaningful single-well seismic data. This report addresses the INEEL tests, theories, observations, and test results.

  11. Strangeness suppression of qq¯ creation observed in exclusive reactions

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Mestayer, M. D.; Park, K.; Adhikari, K. P.; Aghasyan, M.; Pereira, S. Anefalos; Ball, J.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Biselli, A. S.; et al

    2014-10-10

    In this study, we measured the ratios of electroproduction cross sections from a proton target for three exclusive meson-baryon final states: ΛK+, pπ0, and nπ+, with the CLAS detector at Jefferson Lab. Using a simple model of quark hadronization, we extract qq¯ creation probabilities for the first time in exclusive two-body production, in which only a single qq¯ pair is created. We observe a sizable suppression of strange quark-antiquark pairs compared to nonstrange pairs, similar to that seen in high-energy production.

  12. Theory of suppressing avalanche process of carrier in short pulse laser irradiated dielectrics

    SciTech Connect (OSTI)

    Deng, Hongxiang; Zu, Xiaotao; Zheng, WG; Yuan, XD; Xiang, Xia; Sun, Kai; Gao, Fei

    2014-05-28

    A theory for controlling avalanche process of carrier during short pulse laser irradiation is proposed. We show that avalanche process of conduction band electrons (CBEs) is determined by the occupation number of phonons in dielectrics. The theory provides a way to suppress avalanche process and a direct judgment for the contribution of avalanche process and photon ionization process to the generation of CBEs. The obtained temperature dependent rate equation shows that the laser induced damage threshold of dielectrics, e.g., fused silica, increase nonlinearly with the decreases of temperature. Present theory predicts a new approach to improve the laser induced damage threshold of dielectrics.

  13. Commercial and institutional kitchen exhaust systems

    SciTech Connect (OSTI)

    McGuire, A.B. )

    1993-05-01

    This article addresses design requirements for commercial and institutional kitchen exhaust systems. The topics of the article include design considerations, toilet exhaust, dishwasher exhaust, grease hood exhaust, codes and standards, design concerns, common problems, and fire suppression. A side bar on ducts, plenums and housings is also included.

  14. Preliminary conceptual design study of a suppressed-fission tokamak hybrid

    SciTech Connect (OSTI)

    Grady, D.; Berwald, D.; Garner, J.; Jassby, D.; Karbowski, J.; DeVan, J.; Lee, J.D.; Moir, R.W.

    1983-01-01

    A preliminary design concept for a commercial-size tokamak fusion breeder with a suppressed fission blanket and emphasis on /sup 233/U breeding has been formulated. The design is based upon a similar tandem mirror hybrid concept and addresses particular concerns relating to the use of a tokamak for the suppressed fission blanket application. The single most important departure from the tandem mirror reference blanket concept is the substitution of FLIBE for the liquid lithium used for cooling and in-situ tritium breeding. A concern for excessive MHD-related problems drove the decision to replace the more highly conductive lithium. As a result of the new coolant selection, material compatibility issues mandated changes in the composition of the mobile fuel pellets. In addition, the higher operating temperatures associated with the FLIBE placed more stringent constraints on structural requirements and reduced several design margins. Neutronics analyses predicted relatively poor blanket performance with tritium breeding of 1.02 and fissile /sup 233/U breeding of 0.34.

  15. Suppression of hepatic stellate cell activation by microRNA-29b

    SciTech Connect (OSTI)

    Sekiya, Yumiko; Ogawa, Tomohiro; Liver Research Center, Graduate School of Medicine, Osaka City University, Osaka ; Yoshizato, Katsutoshi; Liver Research Center, Graduate School of Medicine, Osaka City University, Osaka; PhoenixBio Co. Ltd., Hiroshima ; Ikeda, Kazuo; Kawada, Norifumi; Liver Research Center, Graduate School of Medicine, Osaka City University, Osaka

    2011-08-19

    Highlights: {yields} Expression of miR-29b was found to be down-regulated during the activation of hepatic stellate cells in primary culture. {yields} Transfection of a miR-29b precursor markedly attenuated the expression of Col1a1 and Col1a2 mRNAs. {yields} It blunted the increased expression of {alpha}-SMA, DDR2, FN1, ITGB1, and PDGFR-b mRNAs essential for stellate cell activation. {yields} miR-29b overexpression led stellate cells to remain in a quiescent state, as evidenced by their star-like morphology. {yields} miR-29b overexpression suppressed the expression of c-fos mRNA. -- Abstract: MicroRNAs (miRNAs) participate in the regulation of cellular functions including proliferation, apoptosis, and migration. It has been previously shown that the miR-29 family is involved in regulating type I collagen expression by interacting with the 3'UTR of its mRNA. Here, we investigated the roles of miR-29b in the activation of mouse primary-cultured hepatic stellate cells (HSCs), a principal collagen-producing cell in the liver. Expression of miR-29b was found to be down-regulated during HSC activation in primary culture. Transfection of a miR-29b precursor markedly attenuated the expression of Col1a1 and Col1a2 mRNAs and additionally blunted the increased expression of {alpha}-SMA, DDR2, FN1, ITGB1, and PDGFR-{beta}, which are key genes involved in the activation of HSCs. Further, overexpression of miR-29b led HSCs to remain in a quiescent state, as evidenced by their quiescent star-like cell morphology. Although phosphorylation of FAK, ERK, and Akt, and the mRNA expression of c-jun was unaffected, miR-29b overexpression suppressed the expression of c-fos mRNA. These results suggested that miR-29b is involved in the activation of HSCs and could be a candidate molecule for suppressing their activation and consequent liver fibrosis.

  16. Antibacterial agent triclosan suppresses RBL-2H3 mast cell function

    SciTech Connect (OSTI)

    Palmer, Rachel K.; Hutchinson, Lee M.; Burpee, Benjamin T.; Tupper, Emily J.; Pelletier, Jonathan H.; Kormendy, Zsolt; Hopke, Alex R.; Malay, Ethan T.; Evans, Brieana L.; Velez, Alejandro; Gosse, Julie A.

    2012-01-01

    Triclosan is a broad-spectrum antibacterial agent, which has been shown previously to alleviate human allergic skin disease. The purpose of this study was to investigate the hypothesis that the mechanism of this action of triclosan is, in part, due to effects on mast cell function. Mast cells play important roles in allergy, asthma, parasite defense, and carcinogenesis. In response to various stimuli, mast cells degranulate, releasing allergic mediators such as histamine. In order to investigate the potential anti-inflammatory effect of triclosan on mast cells, we monitored the level of degranulation in a mast cell model, rat basophilic leukemia cells, clone 2H3. Having functional homology to human mast cells, as well as a very well defined signaling pathway leading to degranulation, this cell line has been widely used to gain insight into mast-cell driven allergic disorders in humans. Using a fluorescent microplate assay, we determined that triclosan strongly dampened the release of granules from activated rat mast cells starting at 2 ?M treatment, with dose-responsive suppression through 30 ?M. These concentrations were found to be non-cytotoxic. The inhibition was found to persist when early signaling events (such as IgE receptor aggregation and tyrosine phosphorylation) were bypassed by using calcium ionophore stimulation, indicating that the target for triclosan in this pathway is likely downstream of the calcium signaling event. Triclosan also strongly suppressed F-actin remodeling and cell membrane ruffling, a physiological process that accompanies degranulation. Our finding that triclosan inhibits mast cell function may explain the clinical data mentioned above and supports the use of triclosan or a mechanistically similar compound as a topical treatment for allergic skin disease, such as eczema. -- Highlights: ?The effects of triclosan on mast cell function using a murine mast cell model. ?Triclosan strongly inhibits degranulation of mast cells. ?Triclosan suppresses membrane ruffling of activated mast cells. ?Triclosan's effects persist when early mast cell signaling events are bypassed. ?Supports use of triclosan as a topical treatment for eczema.

  17. Fission-suppressed fusion breeder on the thorium cycle and nonproliferation

    SciTech Connect (OSTI)

    Moir, R. W.

    2012-06-19

    Fusion reactors could be designed to breed fissile material while suppressing fissioning thereby enhancing safety. The produced fuel could be used to startup and makeup fuel for fission reactors. Each fusion reaction can produce typically 0.6 fissile atoms and release about 1.6 times the 14 MeV neutron's energy in the blanket in the fission-suppressed design. This production rate is 2660 kg/1000 MW of fusion power for a year. The revenues would be doubled from such a plant by selling fuel at a price of 60/g and electricity at $0.05/kWh for Q=P{sub fusion}/P{sub input}=4. Fusion reactors could be designed to destroy fission wastes by transmutation and fissioning but this is not a natural use of fusion whereas it is a designed use of fission reactors. Fusion could supply makeup fuel to fission reactors that were dedicated to fissioning wastes with some of their neutrons. The design for safety and heat removal and other items is already accomplished with fission reactors. Whereas fusion reactors have geometry that compromises safety with a complex and thin wall separating the fusion zone from the blanket zone where wastes could be destroyed. Nonproliferation can be enhanced by mixing {sup 233}U with {sup 238}U. Also nonproliferation is enhanced in typical fission-suppressed designs by generating up to 0.05 {sup 232}U atoms for each {sup 233}U atom produced from thorium, about twice the IAEA standards of 'reduced protection' or 'self protection.' With 2.4%{sup 232}U, high explosive material is predicted to degrade owing to ionizing radiation after a little over 1/2 year and the heat rate is 77 W just after separation and climbs to over 600 W ten years later. The fissile material can be used to fuel most any fission reactor but is especially appropriate for molten salt reactors (MSR) also called liquid fluoride thorium reactors (LFTR) because of the molten fuel does not need hands on fabrication and handling.

  18. Suppression of current fluctuations in a crossed ExB field system for low-voltage plasma immersion treatment

    SciTech Connect (OSTI)

    Levchenko, I.; Keidar, M.; Ostrikov, K.; Yu, M.Y.

    2006-01-01

    Plasma transport in a hybrid dc vacuum arc plasma source for ion deposition and plasma immersion treatment is considered. It is found that external crossed electric and magnetic fields near the substrate can significantly reduce the relative amplitude of ion current fluctuations I{sub f} at the substrate surface. In particular, I{sub f} decreases with the applied magnetic field when the bias voltage exceeds 300 V, thus allowing one to reduce the deviations from the rated process parameters. This phenomenon can be attributed to an interaction between the metal-plasma jet from the arc source and the discharge plasma in the crossed fields.

  19. CKM-suppressed top quark decays t{yields}s(d)+W in the standard model and beyond

    SciTech Connect (OSTI)

    Diaz-Cruz, J. L.; Gaitan-Lozano, R.; Castro, G. Lopez; Pagliarone, C. E.

    2008-05-01

    As it is well known, top quark decays are of particular interest as a means to test the standard model (SM) predictions, these include the dominant (t{yields}b+W), the Cabibbo-Kobayashi-Maskawa (CKM)-suppressed process t{yields}cWW, and the rare decays (t{yields}cV, cVV, c{phi}{sup 0}, bWZ). As all of them are highly suppressed, they become an excellent window to probe the predictions of theories beyond the SM. In this paper, we evaluate the corrections from new physics to the CKM-suppressed SM top quark decay t{yields}q+W(q=d,s), both within an effective model with right-handed currents and for the minimal SUSY extension of the SM. We also discuss the perspectives to probe those predictions at the International Linear Collider.

  20. Effect of power oscillations on suppression pool heating during ATWS (Anticipated Transients Without Scram) conditions

    SciTech Connect (OSTI)

    Wulff, W.; Cheng, H.S.; Mallen, A.N.

    1990-01-01

    Nine selected Anticipated Transients Without Scram (ATWS) have been simulated on the BNL Engineering Plant Analyzer (EPA), to determine how power and flow oscillations, similar to those that did or could have occurred at the LaSalle-2 boiling Water Reactor (BWR), could affect the rate of Pressure Suppression Pool heating. It has been determined that the pool can reach its temperature limit of 80{degree}C in 4.3 min. after Turbine Trip without Bypass, if the feedwater pumps are not tripped. The pool will not reach its limit, if Boron is injected, even when oscillations are encountered. Simultaneous turbine and recirculation pump trips, introduced under stable conditions, can lead to instability. 2 refs., 17 figs., 9 tabs.

  1. Noise suppression in reconstruction of low-Z target megavoltage cone-beam CT images

    SciTech Connect (OSTI)

    Wang Jing; Robar, James; Guan Huaiqun

    2012-08-15

    Purpose: To improve the image contrast-to-noise (CNR) ratio for low-Z target megavoltage cone-beam CT (MV CBCT) using a statistical projection noise suppression algorithm based on the penalized weighted least-squares (PWLS) criterion. Methods: Projection images of a contrast phantom, a CatPhan{sup Registered-Sign} 600 phantom and a head phantom were acquired by a Varian 2100EX LINAC with a low-Z (Al) target and low energy x-ray beam (2.5 MeV) at a low-dose level and at a high-dose level. The projections were then processed by minimizing the PWLS objective function. The weighted least square (WLS) term models the noise of measured projection and the penalty term enforces the smoothing constraints of the projection image. The variance of projection data was chosen as the weight for the PWLS objective function and it determined the contribution of each measurement. An anisotropic quadratic form penalty that incorporates the gradient information of projection image was used to preserve edges during noise reduction. Low-Z target MV CBCT images were reconstructed by the FDK algorithm after each projection was processed by the PWLS smoothing. Results: Noise in low-Z target MV CBCT images were greatly suppressed after the PWLS projection smoothing, without noticeable sacrifice of the spatial resolution. Depending on the choice of smoothing parameter, the CNR of selected regions of interest in the PWLS processed low-dose low-Z target MV CBCT image can be higher than the corresponding high-dose image.Conclusion: The CNR of low-Z target MV CBCT images was substantially improved by using PWLS projection smoothing. The PWLS projection smoothing algorithm allows the reconstruction of high contrast low-Z target MV CBCT image with a total dose of as low as 2.3 cGy.

  2. The FBXW7 {beta}-form is suppressed in human glioma cells

    SciTech Connect (OSTI)

    Gu, Zhaodi; Inomata, Kenichi; Ishizawa, Kota; Horii, Akira . E-mail: horii@mail.tains.tohoku.ac.jp

    2007-03-23

    FBXW7 (F-box and WD40 domain protein 7) is an F-box protein with 7 tandem WDs (tryptophan-aspartic acid) that functions as a phosphoepitope-specific substrate recognition component of SCF (Skp1-Cul1-F-box protein) ubiquitin ligases and catalyzes the ubiquitination of proteins promoting cell proliferation, such as CCNE1, MYC, AURKA, NOTCH1, and JUN, which are frequently activated in a wide range of human cancers. FBXW7 is a candidate tumor suppressor, and mutations have been reported in some human tumors. In this study, we analyzed 84 human tumor cell lines in search for genetic alterations of FBXW7, as well as mRNA and protein expressional changes, and compared them with expression levels of the CCNE1, MYC, and AURKA proteins. We found a novel nonsense mutation in a colon cancer cell line SCC and confirmed the missense mutations in SKOV3, an ovarian cancer cell line, and LoVo, a colon cancer cell line. Moreover, suppressed expression of FBXW7 accompanied by activation of the target proteins were observed in ovarian, colon, endometrial, gastric, and prostate cancers. It is notable that highly suppressed mRNA expression of the FBXW7 {beta}-form was found in all the human glioma cell lines analyzed; enhanced expressions of CCNE1, MYC, and AURKA were observed in these cells. Our present results imply that FBXW7 plays a pivotal role in many tissues by controlling the amount of cell cycle promoter proteins and that dysfunction of this protein is one of the essential steps in carcinogenesis in multiple organs.

  3. Apparatus for suppressing formation of vortices in the coolant fluid of a nuclear reactor and associated method

    DOE Patents [OSTI]

    Ekeroth, Douglas E.; Garner, Daniel C.; Hopkins, Ronald J.; Land, John T.

    1993-01-01

    An apparatus and method are provided for suppressing the formation of vortices in circulating coolant fluid of a nuclear reactor. A vortex-suppressing plate having a plurality of openings therein is suspended within the lower plenum of a reactor vessel below and generally parallel to the main core support of the reactor. The plate is positioned so as to intersect vortices which may form in the circulating reactor coolant fluid. The intersection of the plate with such vortices disrupts the rotational flow pattern of the vortices, thereby disrupting the formation thereof.

  4. Apparatus for suppressing formation of vortices in the coolant fluid of a nuclear reactor and associated method

    DOE Patents [OSTI]

    Ekeroth, D.E.; Garner, D.C.; Hopkins, R.J.; Land, J.T.

    1993-11-30

    An apparatus and method are provided for suppressing the formation of vortices in circulating coolant fluid of a nuclear reactor. A vortex-suppressing plate having a plurality of openings therein is suspended within the lower plenum of a reactor vessel below and generally parallel to the main core support of the reactor. The plate is positioned so as to intersect vortices which may form in the circulating reactor coolant fluid. The intersection of the plate with such vortices disrupts the rotational flow pattern of the vortices, thereby disrupting the formation thereof. 3 figures.

  5. Variation in Use of Androgen Suppression With External-Beam Radiotherapy for Nonmetastatic Prostate Cancer

    SciTech Connect (OSTI)

    Swisher-McClure, Samuel; Pollack, Craig E.; Christodouleas, John P.; Guzzo, Thomas J.; Haas, Naomi B.; Vapiwala, Neha; Bekelman, Justin E.

    2012-05-01

    Purpose: To describe practice patterns associated with androgen suppression (AS) stratified by disease risk group in patients undergoing external-beam radiotherapy (EBRT) for localized prostate cancer. Methods and Materials: We identified 2,184 low-risk, 2,339 intermediate-risk, and 2,897 high-risk patients undergoing EBRT for nonmetastatic prostate cancer diagnosed between January 1, 2004, and December 31, 2005, in the linked Surveillance, Epidemiology, and End Results-Medicare database. We examined the association of patient, clinical, and demographic characteristics with AS use by multivariate logistic regression. Results: The proportions of patients receiving AS for low-risk, intermediate-risk, and high-risk prostate cancer were 32.2%, 56.3%, and 81.5%, respectively. AS use among men in the low-risk disease category varied widely, ranging from 13.6% in Detroit to 47.8% in Kentucky. We observed a significant decline in AS use between 2004 and 2005 within all three disease risk categories. Men aged {>=}75 years or with elevated comorbidity levels were more likely to receive AS. Conclusion: Our results identified apparent overuse and underuse of AS among men within the low-risk and high-risk disease categories, respectively. These results highlight the need for clinician and patient education regarding the appropriate use of AS. Practice patterns among intermediate-risk patients reflect the clinical heterogeneity of this population and underscore the need for better evidence to guide the treatment of these patients.

  6. Strategies to Suppress Cation Vacancies in Metal Oxide Alloys: Consequences for Solar Energy Conversion

    SciTech Connect (OSTI)

    Toroker, Maytal; Carter, Emily A.

    2015-09-01

    First-row transition metal oxides (TMOs) are promising alternative materials for inexpensive and efficient solar energy conversion. However, their conversion efficiency can be deleteriously affected by material imperfections, such as atomic vacancies. In this work, we provide examples showing that in some iron-containing TMOs, iron cation vacancy formation can be suppressed via alloying. We calculate within density functional theory+U theory the iron vacancy formation energy in binary rock-salt oxide alloys that contain iron, manganese, nickel, zinc, and/or magnesium. We demonstrate that formation of iron vacancies is less favorable if we choose to alloy iron(II) oxide with metals that cannot readily accept vacancy-generated holes, e.g., magnesium, manganese, nickel, or zinc. Since there are less available sites for holes and the holes are forced to reside on iron cations, the driving force for iron vacancy formation decreases. These results are consistent with an experiment observing a sharp drop in cation vacancy concentration upon alloying iron(II) oxide with manganese.

  7. Effectively suppressing dissolution of manganese from spinel lithium manganate via a nanoscale surface-doping approach

    SciTech Connect (OSTI)

    Lu, Jun; Zhan, Chun; Wu, Tianpin; Wen, Jianguo; Lei, Yu; Kropf, A. Jeremy; Wu, Huiming; Miller, Dean J.; Elam, Jeffrey W.; Sun, Yang-Kook; Qiu, Xinping; Amine, Khalil

    2014-12-16

    The capacity fade of lithium manganate-based cells is associated with the dissolution of Mn from cathode/electrolyte interface due to the disproportionation reaction of Mn(III), and the subsequent deposition of Mn(II) on the anode. Suppressing the dissolution of Mn from the cathode is critical to reducing capacity fade of LiMn2O4-based cells. Here we report a nanoscale surface-doping approach that minimizes Mn dissolution from lithium manganate. This approach exploits advantages of both bulk doping and surface-coating methods by stabilizing surface crystal structure of lithium manganate through cationic doping while maintaining bulk lithium manganate structure, and protecting bulk lithium manganate from electrolyte corrosion while maintaining ion and charge transport channels on the surface through the electrochemically active doping layer. Consequently, the surface-doped lithium manganate demonstrates enhanced electrochemical performance. This study provides encouraging evidence that surface doping could be a promising alternative to improve the cycling performance of lithium-ion batteries.

  8. Method and apparatus for suppressing regenerative instability and related chatter in machine tools

    DOE Patents [OSTI]

    Segalman, Daniel J.; Redmond, James M.

    2001-01-01

    Methods of and apparatuses for mitigating chatter vibrations in machine tools or components thereof. Chatter therein is suppressed by periodically or continuously varying the stiffness of the cutting tool (or some component of the cutting tool), and hence the resonant frequency of the cutting tool (or some component thereof). The varying of resonant frequency of the cutting tool can be accomplished by modulating the stiffness of the cutting tool, the cutting tool holder, or any other component of the support for the cutting tool. By periodically altering the impedance of the cutting tool assembly, chatter is mitigated. In one embodiment, a cyclic electric (or magnetic) field is applied to the spindle quill which contains an electro-rheological (or magneto-rheological) fluid. The variable yield stress in the fluid affects the coupling of the spindle to the machine tool structure, changing the natural frequency of oscillation. Altering the modal characteristics in this fashion disrupts the modulation of current tool vibrations with previous tool vibrations recorded on the workpiece surface.

  9. Method and apparatus for suppressing regenerative instability and related chatter in machine tools

    DOE Patents [OSTI]

    Segalman, Daniel J.; Redmond, James M.

    1999-01-01

    Methods of and apparatuses for mitigating chatter vibrations in machine tools or components thereof. Chatter therein is suppressed by periodically or continuously varying the stiffness of the cutting tool (or some component of the cutting tool), and hence the resonant frequency of the cutting tool (or some component thereof). The varying of resonant frequency of the cutting tool can be accomplished by modulating the stiffness of the cutting tool, the cutting tool holder, or any other component of the support for the cutting tool. By periodically altering the impedance of the cutting tool assembly, chatter is mitigated. In one embodiment, a cyclic electric (or magnetic) field is applied to the spindle quill which contains an electro-rheological (or magneto-rheological) fluid. The variable yield stress in the fluid affects the coupling of the spindle to the machine tool structure, changing the natural frequency of oscillation. Altering the modal characteristics in this fashion disrupts the modulation of current tool vibrations with previous tool vibrations recorded on the workpiece surface.

  10. Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases

    SciTech Connect (OSTI)

    Li, Jixia; Malakhova, Margarita; Mottamal, Madhusoodanan; Reddy, Kanamata; Kurinov, Igor; Carper, Andria; Langfald, Alyssa; Oi, Naomi; Kim, Myoung Ok; Zhu, Feng; Sosa, Carlos P.; Zhou, Keyuan; Bode, Ann M.; Dong, Zigang

    2012-06-27

    Ultraviolet (UV) irradiation is the leading factor in the development of skin cancer, prompting great interest in chemopreventive agents for this disease. In this study, we report the discovery of norathyriol, a plant-derived chemopreventive compound identified through an in silico virtual screening of the Chinese Medicine Library. Norathyriol is a metabolite of mangiferin found in mango, Hypericum elegans, and Tripterospermum lanceolatum and is known to have anticancer activity. Mechanistic investigations determined that norathyriol acted as an inhibitor of extracellular signal-regulated kinase (ERK)1/2 activity to attenuate UVB-induced phosphorylation in mitogen-activated protein kinases signaling cascades. We confirmed the direct and specific binding of norathyriol with ERK2 through a cocrystal structural analysis. The xanthone moiety in norathyriol acted as an adenine mimetic to anchor the compound by hydrogen bonds to the hinge region of the protein ATP-binding site on ERK2. Norathyriol inhibited in vitro cell growth in mouse skin epidermal JB6 P+ cells at the level of G{sub 2}-M phase arrest. In mouse skin tumorigenesis assays, norathyriol significantly suppressed solar UV-induced skin carcinogenesis. Further analysis indicated that norathyriol mediates its chemopreventive activity by inhibiting the ERK-dependent activity of transcriptional factors AP-1 and NF-{kappa}B during UV-induced skin carcinogenesis. Taken together, our results identify norathyriol as a safe new chemopreventive agent that is highly effective against development of UV-induced skin cancer.

  11. Vibration suppression in cutting tools using collocated piezoelectric sensors/actuators with an adaptive control algorithm

    SciTech Connect (OSTI)

    Radecki, Peter P; Farinholt, Kevin M; Park, Gyuhae; Bement, Matthew T

    2008-01-01

    The machining process is very important in many engineering applications. In high precision machining, surface finish is strongly correlated with vibrations and the dynamic interactions between the part and the cutting tool. Parameters affecting these vibrations and dynamic interactions, such as spindle speed, cut depth, feed rate, and the part's material properties can vary in real-time, resulting in unexpected or undesirable effects on the surface finish of the machining product. The focus of this research is the development of an improved machining process through the use of active vibration damping. The tool holder employs a high bandwidth piezoelectric actuator with an adaptive positive position feedback control algorithm for vibration and chatter suppression. In addition, instead of using external sensors, the proposed approach investigates the use of a collocated piezoelectric sensor for measuring the dynamic responses from machining processes. The performance of this method is evaluated by comparing the surface finishes obtained with active vibration control versus baseline uncontrolled cuts. Considerable improvement in surface finish (up to 50%) was observed for applications in modern day machining.

  12. SPARC-90: A code for calculating fission product capture in suppression pools

    SciTech Connect (OSTI)

    Owczarski, P.C.; Burk, K.W. )

    1991-10-01

    This report describes the technical bases and use of two updated versions of a computer code initially developed to serve as a tool for calculating aerosol particle retention in boiling water reactor (BWR) pressure suppression pools during severe accidents, SPARC-87 and SPARC-90. The most recent version is SPARC-90. The initial or prototype version (Owczarski, Postma, and Schreck 1985) was improved to include the following: rigorous treatment of local particle deposition velocities on the surface of oblate spherical bubbles, new correlations for hydrodynamic behavior of bubble swarms, models for aerosol particle growth, both mechanistic and empirical models for vent exit region scrubbing, specific models for hydrodynamics of bubble breakup at various vent types, and models for capture of vapor iodine species. A complete user's guide is provided for SPARC-90 (along with SPARC-87). A code description, code operating instructions, partial code listing, examples of the use of SPARC-90, and summaries of experimental data comparison studies also support the use of SPARC-90. 29 refs., 4 figs., 11 tabs.

  13. Ionizing Radiation–Inducible miR-27b Suppresses Leukemia Proliferation via Targeting Cyclin A2

    SciTech Connect (OSTI)

    Wang, Bo; Li, Dongping; Kovalchuk, Anna; Litvinov, Dmitry; Kovalchuk, Olga

    2014-09-01

    Purpose: Ionizing radiation is a common carcinogen that is important for the development of leukemia. However, the underlying epigenetic mechanisms remain largely unknown. The goal of the study was to explore microRNAome alterations induced by ionizing radiation (IR) in murine thymus, and to determine the role of IR-inducible microRNA (miRNA/miR) in the development of leukemia. Methods and Materials: We used the well-established C57BL/6 mouse model and miRNA microarray profiling to identify miRNAs that are differentially expressed in murine thymus in response to irradiation. TIB152 human leukemia cell line was used to determine the role of estrogen receptor–α (ERα) in miR-27b transcription. The biological effects of ectopic miR-27b on leukemogenesis were measured by western immunoblotting, cell viability, apoptosis, and cell cycle analyses. Results: Here, we have shown that IR triggers the differential expression of miR-27b in murine thymus tissue in a dose-, time- and sex-dependent manner. miR-27b was significantly down-regulated in leukemia cell lines CCL119 and TIB152. Interestingly, ERα was overexpressed in those 2 cell lines, and it was inversely correlated with miR-27b expression. Therefore, we used TIB152 as a model system to determine the role of ERα in miR-27b expression and the contribution of miR-27b to leukemogenesis. β-Estradiol caused a rapid and transient reduction in miR-27b expression reversed by either ERα-neutralizing antibody or ERK1/2 inhibitor. Ectopic expression of miR-27b remarkably suppressed TIB152 cell proliferation, at least in part, by inducing S-phase arrest. In addition, it attenuated the expression of cyclin A2, although it had no effect on the levels of PCNA, PPARγ, CDK2, p21, p27, p-p53, and cleaved caspase-3. Conclusion: Our data reveal that β-estradiol/ERα signaling may contribute to the down-regulation of miR-27b in acute leukemia cell lines through the ERK1/2 pathway, and that miR-27b may function as a tumor suppressor that inhibits cell proliferation by targeting cyclin A2.

  14. High power laser downhole cutting tools and systems

    SciTech Connect (OSTI)

    Zediker, Mark S; Rinzler, Charles C; Faircloth, Brian O; Koblick, Yeshaya; Moxley, Joel F

    2015-01-20

    Downhole cutting systems, devices and methods for utilizing 10 kW or more laser energy transmitted deep into the earth with the suppression of associated nonlinear phenomena. Systems and devices for the laser cutting operations within a borehole in the earth. These systems and devices can deliver high power laser energy down a deep borehole, while maintaining the high power to perform cutting operations in such boreholes deep within the earth.

  15. High power laser workover and completion tools and systems

    SciTech Connect (OSTI)

    Zediker, Mark S; Rinzler, Charles C; Faircloth, Brian O; Koblick, Yeshaya; Moxley, Joel F

    2014-10-28

    Workover and completion systems, devices and methods for utilizing 10 kW or more laser energy transmitted deep into the earth with the suppression of associated nonlinear phenomena. Systems and devices for the laser workover and completion of a borehole in the earth. These systems and devices can deliver high power laser energy down a deep borehole, while maintaining the high power to perform laser workover and completion operations in such boreholes deep within the earth.

  16. System to control contamination during retrieval of buried TRU waste

    DOE Patents [OSTI]

    Menkhaus, Daniel E.; Loomis, Guy G.; Mullen, Carlan K.; Scott, Donald W.; Feldman, Edgar M.; Meyer, Leroy C.

    1993-01-01

    A system to control contamination during the retrieval of hazardous waste comprising an outer containment building, an inner containment building, within the outer containment building, an electrostatic radioactive particle recovery unit connected to and in communication with the inner and outer containment buildings, and a contaminate suppression system including a moisture control subsystem, and a rapid monitoring system having the ability to monitor conditions in the inner and outer containment buildings.

  17. System to control contamination during retrieval of buried TRU waste

    DOE Patents [OSTI]

    Menkhaus, D.E.; Loomis, G.G.; Mullen, C.K.; Scott, D.W.; Feldman, E.M.; Meyer, L.C.

    1993-04-20

    A system is described to control contamination during the retrieval of hazardous waste comprising an outer containment building, an inner containment building, within the outer containment building, an electrostatic radioactive particle recovery unit connected to and in communication with the inner and outer containment buildings, and a contaminate suppression system including a moisture control subsystem, and a rapid monitoring system having the ability to monitor conditions in the inner and outer containment buildings.

  18. Carbamazepine suppresses calpain-mediated autophagy impairment after ischemia/reperfusion in mouse livers

    SciTech Connect (OSTI)

    Kim, Jae-Sung, E-mail: Jae.Kim@surgery.ufl.edu; Wang, Jin-Hee, E-mail: jin-hee.wang@surgery.ufl.edu; Biel, Thomas G., E-mail: Thomas.Biel@surgery.ufl.edu; Kim, Do-Sung, E-mail: do-sung.kim@surgery.med.ufl.edu; Flores-Toro, Joseph A., E-mail: Joseph.Flores-Toro@surgery.ufl.edu; Vijayvargiya, Richa, E-mail: rvijayvargiya@ufl.edu; Zendejas, Ivan, E-mail: ivan.zendejas@surgery.ufl.edu; Behrns, Kevin E., E-mail: Kevin.Behrns@surgery.ufl.edu

    2013-12-15

    Onset of the mitochondrial permeability transition (MPT) plays a causative role in ischemia/reperfusion (I/R) injury. Current therapeutic strategies for reducing reperfusion injury remain disappointing. Autophagy is a lysosome-mediated, catabolic process that timely eliminates abnormal or damaged cellular constituents and organelles such as dysfunctional mitochondria. I/R induces calcium overloading and calpain activation, leading to degradation of key autophagy-related proteins (Atg). Carbamazepine (CBZ), an FDA-approved anticonvulsant drug, has recently been reported to increase autophagy. We investigated the effects of CBZ on hepatic I/R injury. Hepatocytes and livers from male C57BL/6 mice were subjected to simulated in vitro, as well as in vivo I/R, respectively. Cell death, intracellular calcium, calpain activity, changes in autophagy-related proteins (Atg), autophagic flux, MPT and mitochondrial membrane potential after I/R were analyzed in the presence and absence of 20 ?M CBZ. CBZ significantly increased hepatocyte viability after reperfusion. Confocal microscopy revealed that CBZ prevented calcium overloading, the onset of the MPT and mitochondrial depolarization. Immunoblotting and fluorometric analysis showed that CBZ blocked calpain activation, depletion of Atg7 and Beclin-1 and loss of autophagic flux after reperfusion. Intravital multiphoton imaging of anesthetized mice demonstrated that CBZ substantially reversed autophagic defects and mitochondrial dysfunction after I/R in vivo. In conclusion, CBZ prevents calcium overloading and calpain activation, which, in turn, suppresses Atg7 and Beclin-1 depletion, defective autophagy, onset of the MPT and cell death after I/R. - Highlights: A mechanism of carbamazepine (CBZ)-induced cytoprotection in livers is proposed. Impaired autophagy is a key event contributing to lethal reperfusion injury. The importance of autophagy is extended and confirmed in an in vivo model. CBZ is a potential agent to improve liver function after liver surgery.

  19. Search for CP violation in singly Cabibbo suppressed four-body D decays

    SciTech Connect (OSTI)

    Martinelli, Maurizio; /Bari U.

    2011-06-22

    We search for CP violation in a sample of 4.7 x 10{sup 4} singly Cabibbo suppressed D{sup 0} {yields} K{sup +} K{sup -} {pi}{sup +}{pi}{sup -} decays and 1.8(2.6) x 10{sup 4} D{sub (s)}{sup +} {yields} K{sub S}{sup 0} K{sup +} {pi}{sup +} {pi}{sup -} decays. CP violation is searched for in the difference between the T-odd asymmetries, obtained using triple product correlations, measured for D and {bar D} decays. The measured CP violation parameters are A{sub T}(D{sup 0}) = (1.0 {+-} 5.1(stat) {+-} 4.4(syst)) x 10{sup -3}, A{sub T}(D{sup +}) = (-11.96 {+-} 10.04(stat) {+-} 4.81(syst)) x 10{sup -3} and A{sub T}(D{sub s}{sup +}) = (-13.57 {+-} 7.67(stat) {+-} 4.82(syst)) x 10{sup -3}. This search for CP violation showed that the T-odd correlations are a powerful tool to measure the CP violating observable A{sub T}. The relative simplicity of an analysis based on T-odd correlations and the high quality results that can be obtained, allow to consider this tool as fundamental to search for CP violation in four-body decays. Even if the CP violation has not been found, excluding any New Physics effect to the sensitivity of about 0.5%, it is still worth to search for CP violation in D decays. The high statistics that can be obtained at the LHC or by the proposed high luminosity B-factories, make this topic to be considered in high consideration by experiments such as LHCb, SuperB or SuperBelle. The results outlined in this thesis strongly suggest to include a similar analysis into the Physics program of these experiments.

  20. Ultraviolet GaN photodetectors on Si via oxide buffer heterostructures with integrated short period oxide-based distributed Bragg reflectors and leakage suppressing metal-oxide-semiconductor contacts

    SciTech Connect (OSTI)

    Szyszka, A. E-mail: adam.szyszka@pwr.wroc.pl; Haeberlen, M.; Storck, P.; Thapa, S. B.; Schroeder, T.

    2014-08-28

    Based on a novel double step oxide buffer heterostructure approach for GaN integration on Si, we present an optimized Metal-Semiconductor-Metal (MSM)-based Ultraviolet (UV) GaN photodetector system with integrated short-period (oxide/Si) Distributed Bragg Reflector (DBR) and leakage suppressing Metal-Oxide-Semiconductor (MOS) electrode contacts. In terms of structural properties, it is demonstrated by in-situ reflection high energy electron diffraction and transmission electron microscopy-energy dispersive x-ray studies that the DBR heterostructure layers grow with high thickness homogeneity and sharp interface structures sufficient for UV applications; only minor Si diffusion into the Y{sub 2}O{sub 3} films is detected under the applied thermal growth budget. As revealed by comparative high resolution x-ray diffraction studies on GaN/oxide buffer/Si systems with and without DBR systems, the final GaN layer structure quality is not significantly influenced by the growth of the integrated DBR heterostructure. In terms of optoelectronic properties, it is demonstrated thatwith respect to the basic GaN/oxide/Si system without DBRthe insertion of (a) the DBR heterostructures and (b) dark current suppressing MOS contacts enhances the photoresponsivity below the GaN band-gap related UV cut-off energy by almost up to two orders of magnitude. Given the in-situ oxide passivation capability of grown GaN surfaces and the one order of magnitude lower number of superlattice layers in case of higher refractive index contrast (oxide/Si) systems with respect to classical III-N DBR superlattices, virtual GaN substrates on Si via functional oxide buffer systems are thus a promising robust approach for future GaN-based UV detector technologies.

  1. Background Suppression Using Pulse Shape Analysis with a BEGe Detector for Neutrinoless Double Beta Decay Search with GERDA

    SciTech Connect (OSTI)

    Budjas, Dusan; Schoenert, Stefan [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Chkvorets, Oleg [Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, 69117 Heidelberg (Germany); Department of Physics, Laurentian University, Ramsey Lake Road, P3E 2C6 Sudbury, Ontario (Canada)

    2009-12-17

    A pulse shape analysis for distinguishing between double beta decay-like interactions and multiple-scattered photons was performed for the first time using a BEGe-type detector. This discrimination method is included in the research and development for the second phase of the GERDA experiment, since active background suppression techniques are necessary to reach sensitivity for the {sup 76}Ge neutrinoless double beta decay half life of >10{sup 26} years. A suppression of backgrounds in the energy region of interest around the {sup 76}Ge Q{sub {beta}}{sub {beta}} = 2039 keV is demonstrated, with (0.93{+-}0.08)% survival probability for events from {sup 60}Co, (21{+-}3)% for {sup 226}Ra, and (40{+-}2)% for {sup 228}Th. This performance is achieved with (89{+-}1)% acceptance of {sup 228}Th double escape events, which are analogous to double beta decay.

  2. Protein A suppresses immune responses during Staphylococcus aureus bloodstream infection in guinea pigs

    SciTech Connect (OSTI)

    Kim, Hwan Keun; Falugi, Fabiana; Thomer, Lena; Missiakas, Dominique M.; Schneewind, Olaf

    2015-01-06

    Staphylococcus aureus infection is not associated with the development of protective immunity, and disease relapses occur frequently. We hypothesize that protein A, a factor that binds immunoglobulin Fcγ and cross-links VH3 clan B cell receptors (IgM), is the staphylococcal determinant for host immune suppression. To test this, vertebrate IgM was examined for protein A cross-linking. High VH3 binding activity occurred with human and guinea immunoglobulin, whereas mouse and rabbit immunoglobulins displayed little and no binding, respectively. Establishing a guinea pig model of S. aureus bloodstream infection, we show that protein A functions as a virulence determinant and suppresses host B cell responses. Immunization with SpAKKAA, which cannot bind immunoglobulin, elicits neutralizing antibodies that enable guinea pigs to develop protective immunity.

  3. Explosive destruction system for disposal of chemical munitions

    DOE Patents [OSTI]

    Tschritter, Kenneth L.; Haroldsen, Brent L.; Shepodd, Timothy J.; Stofleth, Jerome H.; DiBerardo, Raymond A.

    2005-04-19

    An explosive destruction system and method for safely destroying explosively configured chemical munitions. The system comprises a sealable, gas-tight explosive containment vessel, a fragment suppression system positioned in said vessel, and shaped charge means for accessing the interior of the munition when the munition is placed within the vessel and fragment suppression system. Also provided is a means for treatment and neutralization of the munition's chemical fills, and means for heating and agitating the contents of the vessel. The system is portable, rapidly deployable and provides the capability of explosively destroying and detoxifying chemical munitions within a gas-tight enclosure so that there is no venting of toxic or hazardous chemicals during detonation.

  4. Initiation disruptor systems and methods of initiation disruption

    DOE Patents [OSTI]

    Baum, Dennis W

    2014-09-23

    A system that may be used as an initiation disruption system (IDS) according to one embodiment includes an explosive charge; a plurality of particles in a layer at least partially surrounding the explosive charge; and a fire suppressant adjacent the plurality of particles. A method for disabling an object according to one embodiment includes placing the system as recited above near an object; and causing the explosive charge to initiate, thereby applying mechanical loading to the object such that the object becomes disabled. Additional systems and methods are also presented. A device according to another embodiment includes a plurality of particles bound by a binder thereby defining a sidewall having an interior for receiving an explosive; and a fire suppressant adjacent the plurality of particles and binder. Additional systems and methods are also presented.

  5. Tensor to scalar ratio and large scale power suppression from pre-slow roll initial conditions

    SciTech Connect (OSTI)

    Lello, Louis; Boyanovsky, Daniel, E-mail: lal81@pitt.edu, E-mail: boyan@pitt.edu [Department of Physics and Astronomy, University of Pittsburgh, 3941 O'Hara St, Pittsburgh, PA 15260 (United States)

    2014-05-01

    We study the corrections to the power spectra of curvature and tensor perturbations and the tensor-to-scalar ratio r in single field slow roll inflation with standard kinetic term due to initial conditions imprinted by a ''fast-roll'' stage prior to slow roll. For a wide range of initial inflaton kinetic energy, this stage lasts only a few e-folds and merges smoothly with slow-roll thereby leading to non-Bunch-Davies initial conditions for modes that exit the Hubble radius during slow roll. We describe a program that yields the dynamics in the fast-roll stage while matching to the slow roll stage in a manner that is independent of the inflationary potentials. Corrections to the power spectra are encoded in a ''transfer function'' for initial conditions T{sub ?}(k), P{sub ?}(k) = P{sup BD}{sub ?}(k)T{sub ?}(k), implying a modification of the ''consistency condition'' for the tensor to scalar ratio at a pivot scale k{sub 0}: r(k{sub 0}) = ?8n{sub T}(k{sub 0})[T{sub T}(k{sub 0})/T{sub R}(k{sub 0})]. We obtain T{sub ?}(k) to leading order in a Born approximation valid for modes of observational relevance today. A fit yields T{sub ?}(k) = 1+A{sub ?}k{sup ?p}cos [2??k/H{sub sr}+?{sub ?}], with 1.5?suppression of the quadrupole and oscillatory features in both P{sub R}(k) and r(k{sub 0}) with a period of the order of the Hubble scale during slow roll inflation. The results are quite general and independent of the specific inflationary potentials, depending solely on the ratio of kinetic to potential energy ? and the slow roll parameters ?{sub V}, ?{sub V} to leading order in slow roll. For a wide range of ? and the values of ?{sub V};?{sub V} corresponding to the upper bounds from Planck, we find that the low quadrupole is consistent with the results from Planck, and the oscillations in r(k{sub 0}) as a function of k{sub 0} could be observable if the modes corresponding to the quadrupole and the pivot scale crossed the Hubble radius very few (23) e-folds after the onset of slow roll. We comment on possible impact on the recent BICEP2 results.

  6. Self-Assembled Monolayers of n-Alkanethiols Suppress Hydrogen Evolution and Increase the Efficiency of Rechargeable Iron Battery Electrodes

    SciTech Connect (OSTI)

    Malkhandi, S; Yang, B; Manohar, AK; Prakash, GKS; Narayanan, SR

    2013-01-09

    Iron-based rechargeable batteries, because of their low cost, eco-friendliness, and durability, are extremely attractive for large-scale energy storage. A principal challenge in the deployment of these batteries is their relatively low electrical efficiency. The low efficiency is due to parasitic hydrogen evolution that occurs on the iron electrode during charging and idle stand. In this study, we demonstrate for the first time that linear alkanethiols are very effective in suppressing hydrogen evolution on alkaline iron battery electrodes. The alkanethiols form self-assembled monolayers on the iron electrodes. The degree of suppression of hydrogen evolution by the alkanethiols was found to be greater than 90%, and the effectiveness of the alkanethiol increased with the chain length. Through steady-state potentiostatic polarization studies and impedance measurements on high-purity iron disk electrodes, we show that the self-assembly of alkanethiols suppressed the parasitic reaction by reducing the interfacial area available for the electrochemical reaction. We have modeled the effect of chain length of the alkanethiol on the surface coverage, charge-transfer resistance, and double-layer capacitance of the interface using a simple model that also yields a value for the interchain interaction energy. We have verified the improvement in charging efficiency resulting from the use of the alkanethiols in practical rechargeable iron battery electrodes. The results of battery tests indicate that alkanethiols yield among the highest faradaic efficiencies reported for the rechargeable iron electrodes, enabling the prospect of a large-scale energy storage solution based on low-cost iron-based rechargeable batteries.

  7. Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS

    SciTech Connect (OSTI)

    Yoon, Sung-Jin; Park, Jun-Young; Choi, Song; Lee, Jin-Bong; Jung, Haiyoung; Kim, Tae-Don; Yoon, Suk Ran; Choi, Inpyo; Shim, Sungbo; Park, Young-Jun

    2015-08-07

    Ginsenoside Rg3, a specific biological effector, is well-known as a major bioactive ingredient of Panax ginseng. However, its role in the inflammasome activation process remains unclear. In this report, we demonstrate that ginsenosides 20(R)-Rg3 and 20(S)-Rg3 are capable of suppressing both lethal endotoxic shock and the S-nitrosylation of the NLRP3 inflammasome by inhibiting nitric oxide (NO) production through the regulation of inducible nitric oxide synthase (iNOS) expression. In response to lipopolysaccharide (LPS), the reducing effect of 20(S)-Rg3 and 20(R)-Rg3 on nitric oxide led to an increase in the survival time of mice after lethal endotoxin-induced shock, and excess levels of NO inhibited IL-1β production via the S-nitrosylation of the NLRP3 inflammasome. In addition, ginsenosides 20(R)-Rg3 and 20(S)-Rg3 had suppressive effects on the LPS- or UV-irradiation-induced reactive oxygen species (ROS) levels in macrophage and HaCaT cells and thereby prevented apoptosis of spleen cells in mice. Altogether, these results demonstrate that ginsenoside 20(R)-Rg3 and 20(S)-Rg3, a naturally occurring compound, might act as a dual therapeutic regulator for the treatment of inflammatory and oxidative stress-related diseases. - Highlights: • Ginsenosides Rg3 inhibits NO production through the regulation of iNOS expression. • Ginsenosides Rg3 inhibits the S-nitrosylation of the NLRP3 inflammasome. • Ginsenosides Rg3 suppress on the LPS- or UV-irradiation-induced ROS levels in cells.

  8. THE SUPPRESSION OF STAR FORMATION AND THE EFFECT OF THE GALAXY ENVIRONMENT IN LOW-REDSHIFT GALAXY GROUPS

    SciTech Connect (OSTI)

    Rasmussen, Jesper; Mulchaey, John S.; Bai, Lei; Ponman, Trevor J.; Raychaudhury, Somak; Dariush, Ali

    2012-10-01

    Understanding the interaction between galaxies and their surroundings is central to building a coherent picture of galaxy evolution. Here we use Galaxy Evolution Explorer imaging of a statistically representative sample of 23 galaxy groups at z Almost-Equal-To 0.06 to explore how local and global group environments affect the UV properties and dust-corrected star formation rates (SFRs) of their member galaxies. The data provide SFRs out to beyond 2R{sub 200} in all groups, down to a completeness limit and limiting galaxy stellar mass of 0.06 M{sub Sun} yr{sup -1} and 1 Multiplication-Sign 10{sup 8} M{sub Sun }, respectively. At fixed galaxy stellar mass, we find that the fraction of star-forming group members is suppressed relative to the field out to an average radius of R Almost-Equal-To 1.5 Mpc Almost-Equal-To 2R{sub 200}, mirroring results for massive clusters. For the first time, we also report a similar suppression of the specific SFR within such galaxies, on average by 40% relative to the field, thus directly revealing the impact of the group environment in quenching star formation within infalling galaxies. At fixed galaxy density and stellar mass, this suppression is stronger in more massive groups, implying that both local and global group environments play a role in quenching. The results favor an average quenching timescale of {approx}> 2 Gyr and strongly suggest that a combination of tidal interactions and starvation is responsible. Despite their past and ongoing quenching, galaxy groups with more than four members still account for at least {approx}25% of the total UV output in the nearby universe.

  9. Suppression of the thermal hysteresis in magnetocaloric MnAs thin film by highly charged ion bombardment

    SciTech Connect (OSTI)

    Trassinelli, M. Marangolo, M.; Eddrief, M.; Etgens, V. H.; Gafton, V.; Hidki, S.; Lacaze, E.; Lamour, E.; Prigent, C.; Rozet, J.-P.; Steydli, S.; Zheng, Y.; Vernhet, D.

    2014-02-24

    We present the investigation on the modifications of structural and magnetic properties of MnAs thin film epitaxially grown on GaAs induced by slow highly charged ions bombardment under well-controlled conditions. The ion-induced defects facilitate the nucleation of one phase with respect to the other in the first-order magneto-structural MnAs transition, with a consequent suppression of thermal hysteresis without any significant perturbation on the other structural and magnetic properties. In particular, the irradiated film keeps the giant magnetocaloric effect at room temperature opening new perspective on magnetic refrigeration technology for everyday use.

  10. Histone deacetylase inhibitor valproic acid promotes the induction of pluripotency in mouse fibroblasts by suppressing reprogramming-induced senescence stress

    SciTech Connect (OSTI)

    Zhai, Yingying; Chen, Xi; Yu, Dehai; Li, Tao; Cui, Jiuwei; Wang, Guanjun; Hu, Ji-Fan; Li, Wei

    2015-09-10

    Histone deacetylase inhibitor valproic acid (VPA) has been used to increase the reprogramming efficiency of induced pluripotent stem cell (iPSC) from somatic cells, yet the specific molecular mechanisms underlying this effect is unknown. Here, we demonstrate that reprogramming with lentiviruses carrying the iPSC-inducing factors (Oct4-Sox2-Klf4-cMyc, OSKM) caused senescence in mouse fibroblasts, establishing a stress barrier for cell reprogramming. Administration of VPA protected cells from reprogramming-induced senescent stress. Using an in vitro pre-mature senescence model, we found that VPA treatment increased cell proliferation and inhibited apoptosis through the suppression of the p16/p21 pathway. In addition, VPA also inhibited the G2/M phase blockage derived from the senescence stress. These findings highlight the role of VPA in breaking the cell senescence barrier required for the induction of pluripotency. - Highlights: • Histone deacetylase inhibitor valproic acid enhances iPSC induction. • Valproic acid suppresses reprogramming-induced senescence stress. • Valproic acid downregulates the p16/p21 pathway in reprogramming. • This study demonstrates a new mechanistic role of valproic acid in enhancing reprogramming.

  11. Piperlongumine selectively suppresses ABC-DLBCL through inhibition of NF-κB p65 subunit nuclear import

    SciTech Connect (OSTI)

    Niu, Mingshan; Shen, Yangling; Xu, Xiaoyu; Yao, Yao; Fu, Chunling; Yan, Zhiling; Wu, Qingyun; Cao, Jiang; Sang, Wei; Zeng, Lingyu; Li, Zhenyu; Liu, Xuejiao; and others

    2015-07-10

    Constitutive NF-κB activation is required for survival of activated B cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL). However, current NF-κB targeting strategies lack cancer cell specificity. Here, we identified a novel inhibitor, piperlongumine, features direct binding to NF-κB p65 subunit and suppression of p65 nuclear import. This was accompanied by NF-κB reporter activity suppression and NF-κB target gene downregulation. Moreover, mutation of Cys{sup 38} to Ser in p65 abolished this effect of piperlongumine on inhibition of p65 nuclear import. Furthermore, we show that piperlongumine selectively inhibited proliferation and induced apoptosis of ABC-DLBCL cells. Most notably, it has been reported that piperlongumine did not affect normal cells even at high doses and was nontoxic to animals. Hence, our current study provides new insight into piperlongumine's mechanism of action and novel approach to ABC-DLBCL target therapy. - Highlights: • Current NF-κB targeting strategies lack cancer cell specificity. • Piperlongumine inhibits NF-κB p65 subunit nuclear import via directly binding to p65. • Piperlongumine selectively inhibits proliferation of ABC-DLBCL cells. • This study provides a novel approach to ABC-DLBCL target therapy.

  12. Alloy Engineering of Defect Properties in Semiconductors: Suppression of Deep Levels in 2D Transition-metal Dichalcogenides

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Huang, Bing; Yoon, Mina; Sumpter, Bobby G; Wei, Su-Huai; Liu, Feng

    2015-09-18

    Developing practical approaches to effectively reduce the deep defect levels in semiconductors is critical for their use in electronic and optoelectronic devices, but this is still a very challenging task. In this Letter, we propose that specific alloying can provide an effective means to suppress the deep defect levels in semiconductors while maintaining their basic electronic properties. Specifically, we demonstrate that for such 2D transition-metal dichalcogenides as MoSe2 and WSe2, in which the most abundant defects that can induce deep levels are anion vacancies, the deep levels can be effectively suppressed in Mo1-xWxSe2 alloys at low W concentrations. This surprisingmore » phenomenon is associated with the fact that the global alloy concentration can substantially tune the band edge energies, whereas the preferred locations of Se vacancies around W atoms control the defect level locally. Our findings illustrate a new concept of alloy engineering and provide a promising approach to control the defect properties of semiconductors.« less

  13. Alloy Engineering of Defect Properties in Semiconductors: Suppression of Deep Levels in 2D Transition-metal Dichalcogenides

    SciTech Connect (OSTI)

    Huang, Bing; Yoon, Mina; Sumpter, Bobby G; Wei, Su-Huai; Liu, Feng

    2015-09-18

    Developing practical approaches to effectively reduce the deep defect levels in semiconductors is critical for their use in electronic and optoelectronic devices, but this is still a very challenging task. In this Letter, we propose that specific alloying can provide an effective means to suppress the deep defect levels in semiconductors while maintaining their basic electronic properties. Specifically, we demonstrate that for such 2D transition-metal dichalcogenides as MoSe2 and WSe2, in which the most abundant defects that can induce deep levels are anion vacancies, the deep levels can be effectively suppressed in Mo1-xWxSe2 alloys at low W concentrations. This surprising phenomenon is associated with the fact that the global alloy concentration can substantially tune the band edge energies, whereas the preferred locations of Se vacancies around W atoms control the defect level locally. Our findings illustrate a new concept of alloy engineering and provide a promising approach to control the defect properties of semiconductors.

  14. Resolved H I imaging of a population of massive H I-rich galaxies with suppressed star formation

    SciTech Connect (OSTI)

    Lemonias, Jenna J.; Schiminovich, David; Catinella, Barbara; Heckman, Timothy M.; Moran, Sean M.

    2014-07-20

    Despite the existence of well-defined relationships between cold gas and star formation, there is evidence that some galaxies contain large amounts of H I that do not form stars efficiently. By systematically assessing the link between H I and star formation within a sample of galaxies with extremely high H I masses (log M{sub H{sub I}}/M{sub ?} > 10), we uncover a population of galaxies with an unexpected combination of high H I masses and low specific star formation rates that exists primarily at stellar masses greater than log M{sub *}/M{sub ?} ? 10.5. We obtained H I maps of 20 galaxies in this population to understand the distribution of the H I and the physical conditions in the galaxies that could be suppressing star formation in the presence of large quantities of H I. We find that all of the galaxies we observed have low H I surface densities in the range in which inefficient star formation is common. The low H I surface densities are likely the main cause of the low specific star formation rates, but there is also some evidence that active galactic nuclei or bulges contribute to the suppression of star formation. The sample's agreement with the global star formation law highlights its usefulness as a tool for understanding galaxies that do not always follow expected relationships.

  15. Suppressing tin whisker growth in lead-free solders and platings

    DOE Patents [OSTI]

    Hoffman, Elizabeth N; Lam, Poh-Sang

    2014-04-29

    A process of irradiation Sn containing Pb-free solder to mitigate whisker formation and growth thereon is provided. The use of gamma radiation such as cobalt-60 has been applied to a substrate of Sn on copper has been found to change the morphology of the crystalline whisker growth to a more truncated hillock pattern. The change in morphology greatly reduces the tendency of whiskers to contribute to electrical short-circuits being used as a Pb-free solder system on a copper substrate.

  16. Enhanced Control of PWR Primary Coolant Water Chemistry Using Selective Separation Systems for Recovery and Recycle of Enriched Boric Acid

    SciTech Connect (OSTI)

    Ken Czerwinski; Charels Yeamans; Don Olander; Kenneth Raymond; Norman Schroeder; Thomas Robison; Bryan Carlson; Barbara Smit; Pat Robinson

    2006-02-28

    The objective of this project is to develop systems that will allow for increased nuclear energy production through the use of enriched fuels. The developed systems will allow for the efficient and selective recover of selected isotopes that are additives to power water reactors' primary coolant chemistry for suppression of corrosion attack on reactor materials.

  17. Suppression of somatic expansion delays the onset of pathophysiology in a mouse model of Huntington’s Disease

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Budworth, Helen; Harris, Faye R.; Williams, Paul; Lee, Do Yup; Holt, Amy; Pahnke, Jens; Szczesny, Bartosz; Acevedo-Torres, Karina; Ayala-Peña, Sylvette; McMurray, Cynthia T.; et al

    2015-08-06

    Huntington’s Disease (HD) is caused by inheritance of a single disease-length allele harboring an expanded CAG repeat, which continues to expand in somatic tissues with age. The inherited disease allele expresses a toxic protein, and whether further somatic expansion adds to toxicity is unknown. We have created an HD mouse model that resolves the effects of the inherited and somatic expansions. We show here that suppressing somatic expansion substantially delays the onset of disease in littermates that inherit the same disease-length allele. Furthermore, a pharmacological inhibitor, XJB-5-131, inhibits the lengthening of the repeat tracks, and correlates with rescue of motormore » decline in these animals. The results provide evidence that pharmacological approaches to offset disease progression are possible.« less

  18. Blinking suppression of CdTe quantum dots on epitaxial graphene and the analysis with Marcus electron transfer

    SciTech Connect (OSTI)

    Hirose, Takuya; Tamai, Naoto, E-mail: tamai@kwansei.ac.jp [Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo 669-1337 (Japan); Kutsuma, Yasunori; Kurita, Atsusi; Kaneko, Tadaaki [Department of Physics, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo 669-1337 (Japan)

    2014-08-25

    We have prepared epitaxial graphene by a Si sublimation method from 4H-SiC. Single-particle spectroscopy of CdTe quantum dots (QDs) on epitaxial graphene covered with polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG) showed the suppression of luminescence blinking and ?10 times decreased luminescence intensity as compared with those on a glass. The electronic coupling constant, H{sub 01}, between CdTe QDs and graphene was calculated to be (3.3??0.4)??10{sup 2?}cm{sup ?1} in PVP and (3.7??0.8)??10{sup 2?}cm{sup ?1} in PEG based on Marcus theory of electron transfer and Tang-Marcus model of blinking with statistical distribution.

  19. Suppression of somatic expansion delays the onset of pathophysiology in a mouse model of Huntington’s Disease

    SciTech Connect (OSTI)

    Budworth, Helen; Harris, Faye R.; Williams, Paul; Lee, Do Yup; Holt, Amy; Pahnke, Jens; Szczesny, Bartosz; Acevedo-Torres, Karina; Ayala-Peña, Sylvette; McMurray, Cynthia T.; McKinnon, Peter

    2015-08-06

    Huntington’s Disease (HD) is caused by inheritance of a single disease-length allele harboring an expanded CAG repeat, which continues to expand in somatic tissues with age. The inherited disease allele expresses a toxic protein, and whether further somatic expansion adds to toxicity is unknown. We have created an HD mouse model that resolves the effects of the inherited and somatic expansions. We show here that suppressing somatic expansion substantially delays the onset of disease in littermates that inherit the same disease-length allele. Furthermore, a pharmacological inhibitor, XJB-5-131, inhibits the lengthening of the repeat tracks, and correlates with rescue of motor decline in these animals. The results provide evidence that pharmacological approaches to offset disease progression are possible.

  20. Suppression of chaotic vibrations in a nonlinear half-car model

    SciTech Connect (OSTI)

    Tusset, ngelo Marcelo E-mail: piccirillo@utfpr.edu.br E-mail: wagner-barth@hotmail.com; Piccirillo, Vincius E-mail: piccirillo@utfpr.edu.br E-mail: wagner-barth@hotmail.com; Janzen, Frederic Conrad E-mail: piccirillo@utfpr.edu.br E-mail: wagner-barth@hotmail.com; Lenz, Wagner Barth E-mail: piccirillo@utfpr.edu.br E-mail: wagner-barth@hotmail.com; Balthazar, Jos Manoel; Fonseca Brasil, Reyolando M. L. R. da

    2014-12-10

    The present work investigates the nonlinear response of a half-car model. The disturbances of the road are assumed to be sinusoidal. After constructing the bifurcation diagram, we using the 0-1 test for identify the chaotic motion. The principal objective of this study is to eliminate the chaotic behaviour of the chassis and reduce its vibration, and for this reason a control system for semi-active vehicle suspension with magnetorheological damper is proposed. The control mechanism is designed based on SDRE technique, where the control parameter is the voltage applied to the coil of the damper. Numerical results show that the proposed control method is effective in significantly reducing of the chassis vibration, increasing therefore, passenger comfort.

  1. Preferential cytotoxicity of bortezomib toward highly malignant human liposarcoma cells via suppression of MDR1 expression and function

    SciTech Connect (OSTI)

    Hu, Yamei; Wang, Lingxian; Wang, Lu; Wu, Xuefeng; Wu, Xudong; Gu, Yanhong; Shu, Yongqian; Sun, Yang; Shen, Yan; Xu, Qiang

    2015-02-15

    Liposarcoma is the most common soft tissue sarcoma with a high risk of relapse. Few therapeutic options are available for the aggressive local or metastatic disease. Here, we report that the clinically used proteasome inhibitor bortezomib exhibits significantly stronger cytotoxicity toward highly malignant human liposarcoma SW872-S cells compared with its parental SW872 cells, which is accompanied by enhanced activation of apoptotic signaling both in vitro and in vivo. Treatment of cells with Jun-N-terminal kinase (JNK) inhibitor SP60015 or the translation inhibitor cycloheximide ameliorated this enhanced apoptosis. Bortezomib inhibited MDR1 expression and function more effectively in SW872-S cells than in SW872 cells, indicating that the increased cytotoxicity relies on the degree of proteasome inhibition. Furthermore, the pharmacological or genetic inhibition of sarco/endoplasmic reticulum calcium-ATPase (SERCA) 2, which is highly expressed in SW872-S cells, resulted in partial reversal of cell growth inhibition and increase of MDR1 expression in bortezomib-treated SW872-S cells. These results show that bortezomib exhibits preferential cytotoxicity toward SW872-S cells possibly via highly expressed SERCA2-associated MDR1 suppression and suggest that bortezomib may serve as a potent agent for treating advanced liposarcoma. - Highlights: • We compare the cytotoxicity of different drugs between SW872-S and SW872 cells. • Highly malignant liposarcoma cells SW872-S show hypersensitivity to bortezomib. • Apoptotic signaling is robustly enhanced in bortezomib-treated SW872-S cells. • Bortezomib has strong suppression on MDR1 expression and function in SW872-S cells. • Inhibition of SERCA2 protects SW872-S cells from bortezomib.

  2. Suppression of Upsilon production in d + Au and Au + Au collisions at root s(NN) = 200 GeV (vol 735, pg 127, 2014)

    SciTech Connect (OSTI)

    Adamczyk, L.; Adkins, J. K.; Agakishiev, G.; Aggarwal, M. M.; Ahammed, Z.; Alekseev, I.; Alford, J.; Anson, C. D.; Aparin, A.; Arkhipkin, D.; Gliske, S.; Krueger, K.; Spinka, H. M.; Underwood, D.G.

    2014-07-30

    We report measurements of ? meson production in p + p, d +Au, and Au+Aucollisions using the STAR detector at RHIC. We compare the ? yield to the measured cross section in p + p collisions in order to quantify any modifications of the yield in cold nuclear matter using d +Au data and in hot nuclear matter using Au+Au data separated into three centrality classes. Our p +p measurement is based on three times the statistics of our previous result. We obtain a nuclear modification factor for ? (1S + 2S + 3S) in the rapidity range |y| < 1 in d + Aucollisions of RdAu = 0.79 0.24(stat.) 0.03(syst.) 0.10(p + p syst.). A comparison with models including shadowing and initial state parton energy loss indicates the presence of additional cold-nuclear matter suppression. Similarly, in the top 10% most-central Au + Au collisions, we measure a nuclear modification factor of R AA = 0.49 0.1(stat.) 0.02(syst.) 0.06(p + p syst.), which is a larger suppression factor than that seen in cold nuclear matter. Our results are consistent with complete suppression of excited-state ? mesons in Au + Aucollisions. The additional suppression in Au + Au is consistent with the level expected in model calculations that include the presence of a hot, deconfined QuarkGluon Plasma. However, understanding the suppression seen in d + Au is still needed before any definitive statements about the nature of the suppression in Au + Au can be made.

  3. Electrical current suppression in Pd-doped vanadium pentoxide nanowires caused by reduction in PdO due to hydrogen exposure

    SciTech Connect (OSTI)

    Kim, Byung Hoon; Oh, Soon-Young; Yu, Han Young; Yun, Yong Ju; Kim, Yark Yeon; Hong, Won G.; Jeong, Hu Young; Lee, Jeong Yong; Kim, Hae Jin

    2010-04-19

    Pd nanoparticle-doped vanadium pentoxide nanowires (Pd-VONs) were synthesized. Electrical current suppression was observed when the Pd-VON was exposed to hydrogen gas, which cannot be explained by the work function changes mentioned in previous report such as Pd-doped carbon nanotubes and SnO{sub 2} nanowires. Using the x-ray photoelectron spectroscopy, we found that the reduction in PdO due to hydrogen exposure plays an important role in the current suppression of the Pd-VON.

  4. Suppression of fiber modal noise induced radial velocity errors for bright emission-line calibration sources

    SciTech Connect (OSTI)

    Mahadevan, Suvrath; Halverson, Samuel; Ramsey, Lawrence; Venditti, Nick

    2014-05-01

    Modal noise in optical fibers imposes limits on the signal-to-noise ratio (S/N) and velocity precision achievable with the next generation of astronomical spectrographs. This is an increasingly pressing problem for precision radial velocity spectrographs in the near-infrared (NIR) and optical that require both high stability of the observed line profiles and high S/N. Many of these spectrographs plan to use highly coherent emission-line calibration sources like laser frequency combs and Fabry-Perot etalons to achieve precision sufficient to detect terrestrial-mass planets. These high-precision calibration sources often use single-mode fibers or highly coherent sources. Coupling light from single-mode fibers to multi-mode fibers leads to only a very low number of modes being excited, thereby exacerbating the modal noise measured by the spectrograph. We present a commercial off-the-shelf solution that significantly mitigates modal noise at all optical and NIR wavelengths, and which can be applied to spectrograph calibration systems. Our solution uses an integrating sphere in conjunction with a diffuser that is moved rapidly using electrostrictive polymers, and is generally superior to most tested forms of mechanical fiber agitation. We demonstrate a high level of modal noise reduction with a narrow bandwidth 1550 nm laser. Our relatively inexpensive solution immediately enables spectrographs to take advantage of the innate precision of bright state-of-the art calibration sources by removing a major source of systematic noise.

  5. Measurement of Branching Ratios for Non-leptonic Cabibbo-suppressed Decays of the Charmed-Strange Baryon Xic+

    SciTech Connect (OSTI)

    Vazquez Jauregui, Eric; /San Luis Potosi U.

    2008-08-01

    We studied several {Xi}{sub c}{sup +} decay modes, most of them with a hyperon in the final state, and determined their branching ratios. The data used in this analysis come from the fixed target experiment SELEX, a multi-stage spectrometer with high acceptance for forward interactions, that took data during 1996 and 1997 at Fermilab with 600 GeV=c (mainly {Sigma}{sup -}, {pi}{sup -}) and 540 GeV/c (mainly p) beams incident on copper and carbon targets. The thesis mainly details the first observation of two Cabibbo-suppressed decay modes, {Xi}{sub c}{sup +} {yields} {Sigma}{sup +}{pi}{sup -}{pi}{sup +} and {Xi}{sub c}{sup +} {yields} {Sigma}{sup -}{pi}{sup +}{pi}{sup +}. The branching ratios of the decays relative to the Cabibbo-favored {Xi}{sub c}{sup +} {yields} {Xi}{sup -}{pi}{sup +}{pi}{sup +} are measured to be: {Lambda}({Xi}{sub c}{sup +} {yields} {Sigma}{sup -}{pi}{sup +}{pi}{sup +})/{Lambda}({Xi}{sub c}{sup +} {yields} {Xi}{sup -}{pi}{sup +}{pi}{sup +}) = 0.184 {+-} 0.086. Systematic studies have been performed in order to check the stability of the measurements varying all cuts used in the selection of events over a wide interval and we do not observe evidence of any trend, so the systematic error is negligible in the final results because the quadrature sum of the total error is not affected. The branching ratios for the same decay modes of the {Lambda}{sub c}{sup +} are measured to check the methodology of the analysis. The branching ratio of the decay mode {Lambda}{sub c}{sup +} {yields} {Sigma}{sup +}{pi}{sup -}{pi}{sup +} is measured relative to {Lambda}{sub c}{sup +} {yields} pK{sup -} {pi}{sup +}, while the one of the decay mode {Lambda}{sub c}{sup +} {yields} {Sigma}{sup -}{pi}{sup +}{pi}{sup +} is relative to {Lambda}{sub c}{sup +} {yields} {Sigma}{sup +}{pi}{sup -}{pi}{sup +}, as they have been reported earlier. The results for the control modes are: {Gamma}({Lambda}{sub c}{sup +} {yields} {Sigma}{sup +}{pi}{sup -}{pi}{sup +})/{Gamma}({Lambda}{sub c}{sup +} {yields} pK{sup -} {pi}{sup +}) = 0.716 {+-} 0.144 and {Gamma}({Lambda}{sub c}{sup +} {yields} {Sigma}{sup -}{pi}{sup +}{pi}{sup +})/{Gamma}({Lambda}{sub c}{sup +} {yields} {Sigma}{sup +}{pi}{sup -}{pi}{sup +}) = 0.382 {+-} 0.104. The branching ratio of the decay mode {Xi}{sub c}{sup +} {yields} pK{sup -} {pi}{sup +} relative to {Xi}{sub c}{sup +} {yields} {Xi}{sup -}{pi}{sup +}{pi}{sup +} is considered as another control mode, the measured value is {Gamma}({Xi}{sub c}{sup +} {yields} pK{sup -}{pi}{sup +})/{Gamma}({Xi}{sub c}{sup +} {yields} {Xi}{sup -}{pi}{sup +}{pi}{sup +}) = 0.194 {+-} 0.054. Systematic studies have been also performed for the control modes and all systematic variations are also small compared to the statistical error. We also report the first observation of two more decay modes, the Cabibbo-suppressed decay {Xi}{sub c}{sup +} {yields} {Xi}{sup -} K{sup +}{pi}{sup +} and the doubly Cabibbo-suppressed decay {Xi}{sub c}{sup +} {yields} {Sigma}{sup +}K{sup +}{pi}{sup -}, but their branching ratios have not been measured up to now.

  6. All-or-none suppression of B cell terminal differentiation by environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin

    SciTech Connect (OSTI)

    Zhang, Qiang; Kline, Douglas E.; Bhattacharya, Sudin; Crawford, Robert B.; Conolly, Rory B.; Thomas, Russell S.; Andersen, Melvin E.; Kaminski, Norbert E.

    2013-04-01

    Many environmental contaminants can disrupt the adaptive immune response. Exposure to the ubiquitous aryl hydrocarbon receptor (AhR) ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other agonists suppresses the antibody response. The underlying pathway mechanism by which TCDD alters B cell function is not well understood. The present study investigated the mechanism of AhR-mediated pathways and mode of suppression by which TCDD perturbs terminal differentiation of B cells to plasma cells and thereby impairs antibody production. An integrated approach combining computational pathway modeling and in vitro assays with primary mouse B cells activated by lipopolysaccharide was employed. We demonstrated that suppression of the IgM response by TCDD occurs in an all-or-none (binary) rather than graded mode: i.e., it reduces the number of IgM-secreting cells in a concentration-dependent manner without affecting the IgM content in individual plasma cells. The mathematical model of the gene regulatory circuit underpinning B cell differentiation revealed that two previously identified AhR-regulated pathways, inhibition of signaling protein AP-1 and activation of transcription factor Bach2, could account for the all-or-none mode of suppression. Both pathways disrupt the operation of a bistable-switch circuit that contains transcription factors Bcl6, Prdm1, Pax5, and Bach2 and regulates B cell fate. The model further predicted that by transcriptionally activating Bach2, TCDD might delay B cell differentiation and increase the likelihood of isotype switching, thereby altering the antibody repertoire. In conclusion, the present study revealed the mode and specific pathway mechanisms by which the environmental immunosuppressant TCDD suppresses B cell differentiation. - Highlights: ? TCDD suppresses B cell differentiation stimulated by LPS in an all-or-none mode. ? TCDD reduces the fraction of IgM-secreting cells, not the IgM level in those cells. ? A mathematical model indicates deregulation of AP-1 and Bach2 by AhR is involved. ? Both pathways interfere with the bistable switch underlying B cell differentiation. ? Disruption of the bistable switch leads to all-or-none mode of suppression.

  7. COMMISSIONING OF THE DIGITAL TRANSVERSE BUNCH-BY-BUNCH FEEDBACK SYSTEM FOR THE TLS.

    SciTech Connect (OSTI)

    HU, K.H.; KUO, C.H.; CHOU, P.J.; LEE, D.; HSU, S.Y.; CHEN, J.; WANG, C.J.; HSU, K.T.; KOBAYASHI, K.; NAKAMURA, T.; CHAO, A.W.; WENG, W.T.

    2006-06-26

    Multi-bunch instabilities degrade beam quality through increased beam emittance, energy spread and even beam loss. Feedback systems are used to suppress multi-bunch instabilities associated with the resistive wall of the beam ducts, cavity-like structures, and trapped ions. A new digital transverse bunch-by-bunch feedback system has recently been commissioned at the Taiwan Light Source, and has replaced the previous analog system. The new system has the advantages that it enlarges the tune acceptance and improves damping for transverse instability at high currents, such that top-up operation is achieved. After a coupled-bunch transverse instability was suppressed, more than 350 mA was successfully stored during preliminary commissioning. In this new system, a single feedback loop simultaneously suppresses both horizontal and vertical multi-bunch instabilities. Investigating the characteristics of the feedback loop and further improving the system performances are the next short-term goals. The feedback system employs the latest generation of field-programmable gate array (FPGA) processor to process bunch signals. Memory has been installed to capture up to 250 msec of bunch oscillation signal, considering system diagnostics suitable to support various beam physics studies.

  8. System Diagram

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    System Diagram System Diagram Diagram of IO architecture on Hopper Diagram of external IO services on the Hopper system Last edited: 2011-04-14 15:11:1...

  9. File Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    on PDSF please see Eliza File Systems and Other File Systems. Below is a summary of how ATLAS uses the various systems: common In the past ATLAS used common primarily for their...

  10. System Diagram

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    System Diagram System Diagram Diagram of I/O architecture on Hopper Diagram of external I/O services on the Hopper system Last edited: 2016-04-29 11:35:23

  11. Fire suppressing apparatus

    DOE Patents [OSTI]

    Buttrey, Kenneth E.

    1982-11-02

    Apparatus for smothering a liquid sodium fire comprises a pan, a perforated cover on the pan, and tubes depending from the cover and providing communication between the interior of the pan and the ambient atmosphere through the perforations in the cover. Liquid caught in the pan rises above the lower ends of the tubes and thus serves as a barrier which limits the amount of air entering the pan.

  12. Computer System,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    undergraduate summer institute http:isti.lanl.gov (Educational Prog) 2016 Computer System, Cluster, and Networking Summer Institute Purpose The Computer System,...

  13. Trisomy of the Dscr1 gene suppresses early progression of pancreatic intraepithelial neoplasia driven by oncogenic Kras

    SciTech Connect (OSTI)

    Lee, Jang Choon; Shin, Jimin; Baek, Kwan-Hyuck

    2013-10-11

    Highlights: A single extra copy of Dscr1 restrains progression of PanIN-1A to PanIN-1B lesions. Dscr1 trisomy attenuates calcineurinNFAT pathway in neoplastic ductal epithelium. Dscr1 trisomy leads to upregulation of p15{sup INK4b} in neoplastic ductal epithelium. A single extra copy of Dscr1 reduces epithelial proliferation in early PanIN lesions. Dscr1 trisomy may protect Down syndrome individuals from pancreatic cancer. -- Abstract: Individuals with Down syndrome exhibit remarkably reduced incidence of most solid tumors including pancreatic cancer. Multiple mechanisms arising from the genetic complexity underlying Down syndrome has been suggested to contribute to such a broad cancer protection. In this study, utilizing a genetically engineered mouse model of pancreatic cancer, we demonstrate that trisomy of the Down syndrome critical region-1 (Dscr1), an endogenous calcineurin inhibitor localized on chromosome 21, suppresses the progression of pancreatic intraepithelial neoplasia-1A (PanIN-1A) to PanIN-1B lesions without affecting the initiation of PanIN lesions mediated by oncogenic Kras{sup G12D}. In addition, we show that Dscr1 trisomy attenuates nuclear localization of nuclear factor of activated T-cells (NFAT) accompanied by upregulation of the p15{sup Ink4b} tumor suppressor and reduction of cell proliferation in early PanIN lesions. Our data suggest that attenuation of calcineurinNFAT signaling in neoplastic pancreatic ductal epithelium by a single extra copy of Dscr1 is sufficient to inhibit the progression of early PanIN lesions driven by oncogenic Kras, and thus may be a potential mechanism underlying reduced incidence of pancreatic cancer in Down syndrome individuals.

  14. miR-214 promotes the proliferation and invasion of osteosarcoma cells through direct suppression of LZTS1

    SciTech Connect (OSTI)

    Xu, Zhengyu; Wang, Tao

    2014-06-27

    Highlights: • miR-214 is upregulated in human OS tissues and inversely correlated with LZTS1 expression. • miR-214 directly targets LZTS1 by binding to its 3′-UTR. • miR-214 promotes OS cell proliferation, invasion and tumor growth. • Overexpression of LZTS1 reverses miR-214-induced proliferation and invasion of OS cells. - Abstract: Previous studies have shown that miR-214 functions either as an oncogene or a tumor suppressor in various human cancer types. The role of this microRNA in osteosarcoma (OS) is presently unclear. Here, we demonstrated that miR-214 is frequently upregulated in OS specimens, compared with noncancerous bone tissues. Bioinformatics analysis further revealed leucine zipper, putative tumor suppressor 1 (LZTS1) as a potential target of miR-214. Expression patterns of miR-214 were inversely correlated with those of LZTS1 mRNA and protein in OS tissues. Data from reporter assays showed that miR-214 directly binds to the 3′-untranslated region (3′-UTR) of LZTS1 mRNA and suppresses expression at both transcriptional and translational levels. In functional assays, miR-214 promoted OS cell proliferation, invasion and tumor growth in nude mice, which could be reversed by overexpression of LZTS1. Taken together, our data provide compelling evidence that miR-214 functions as an onco-miRNA in OS, and its oncogenic effects are mediated chiefly through downregulation of LZTS1.

  15. Suppression and nonlinear excitation of parasitic modes in second harmonic gyrotrons operating in a very high order mode

    SciTech Connect (OSTI)

    Nusinovich, Gregory S.; Pu, Ruifeng; Granatstein, Victor L.

    2015-07-06

    In recent years, there was an active development of high-power, sub-terahertz (sub-THz) gyrotrons for numerous applications. For example, a 0.67 THz gyrotron delivering more than 200 kW with about 20% efficiency was developed. This record high efficiency was achieved because the gyrotron operated in a high-order TE{sub 31,8}-mode with the power of ohmic losses less than 10% of the power of outgoing radiation. That gyrotron operated at the fundamental cyclotron resonance, and a high magnetic field of about 27 T was created by a pulse solenoid. For numerous applications, it is beneficial to use gyrotrons at cyclotron harmonics which can operate in available cryomagnets with fields not exceeding 15 T. However, typically, the gyrotron operation at harmonics faces severe competition from parasitic modes at the fundamental resonance. In the present paper, we consider a similar 0.67 THz gyrotron designed for operation in the same TE{sub 31,8}-mode, but at the second harmonic. We focus on two nonlinear effects typical for interaction between the fundamental and second harmonic modes, viz., the mode suppression and the nonlinear excitation of the mode at the fundamental harmonic by the second harmonic oscillations. Our study includes both the analytical theory and numerical simulations performed with the self-consistent code MAGY. The simulations show that stable second harmonic operation in the TE{sub 31,8} mode is possible with only modest sacrifice of efficiency and power.

  16. MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting {beta}-catenin

    SciTech Connect (OSTI)

    Sun, Jian-Yong; State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, 710032 Xi'an ; Huang, Yi; Li, Ji-Peng; Zhang, Xiang; Wang, Lei; Meng, Yan-Ling; Yan, Bo; Bian, Yong-Qian; Zhao, Jing; Wang, Wei-Zhong; and others

    2012-04-20

    Highlights: Black-Right-Pointing-Pointer miR-320a is downregulated in human colorectal carcinoma. Black-Right-Pointing-Pointer Overexpression of miR-320a inhibits colon cancer cell proliferation. Black-Right-Pointing-Pointer {beta}-Catenin is a direct target of miR-320a in colon cancer cells. Black-Right-Pointing-Pointer miR-320a expression inversely correlates with mRNA expression of {beta}-catenin's target genes in human colon carcinoma. -- Abstract: Recent profile studies of microRNA (miRNA) expression have documented a deregulation of miRNA (miR-320a) in human colorectal carcinoma. However, its expression pattern and underlying mechanisms in the development and progression of colorectal carcinoma has not been elucidated clearly. Here, we performed real-time PCR to examine the expression levels of miR-320a in colon cancer cell lines and tumor tissues. And then, we investigated its biological functions in colon cancer cells by a gain of functional strategy. Further more, by the combinational approaches of bioinformatics and experimental validation, we confirmed target associations of miR-320a in colorectal carcinoma. Our results showed that miR-320a was frequently downregulated in cancer cell lines and colon cancer tissues. And we demonstrated that miR-320a restoration inhibited colon cancer cell proliferation and {beta}-catenin, a functionally oncogenic molecule was a direct target gene of miR-320a. Finally, the data of real-time PCR showed the reciprocal relationship between miR-320a and {beta}-catenin's downstream genes in colon cancer tissues. These findings indicate that miR-320a suppresses the growth of colon cancer cells by directly targeting {beta}-catenin, suggesting its application in prognosis prediction and cancer treatment.

  17. Observation of the Cabibbo-suppressed charmed baryon decay {Lambda}{sub {ital c}}{sup +}{r_arrow}{ital p}{phi}

    SciTech Connect (OSTI)

    Alexander, J.P.; Bebek, C.; Berger, B.E.; Berkelman, K.; Bloom, K.; Browder, T.E.; Cassel, D.G.; Cho, H.A.; Coffman, D.M.; Crowcroft, D.S.; Dickson, M.; Drell, P.S.; Dumas, D.J.; Ehrlich, R.; Elia, R.; Gaidarev, P.; Garcia-Sciveres, M.; Gittelman, B.; Gray, S.W.; Hartill, D.L.; Heltsley, B.K.; Henderson, S.; Jones, C.D.; Jones, S.L.; Kandaswamy, J.; Katayama, N.; Kim, P.C.; Kreinick, D.L.; Lee, T.; Liu, Y.; Ludwig, G.S.; Masui, J.; Mevissen, J.; Mistry, N.B.; Ng, C.R.; Nordberg, E.; Patterson, J.R.; Peterson, D.; Riley, D.; Soffer, A.; Avery, P.; Freyberger, A.; Lingel, K.; Prescott, C.; Rodriguez, J.; Yang, S.; Yelton, J.; Brandenburg, G.; Cinabro, D.; Liu, T.; Saulnier, M.; Wilson, R.; Yamamoto, H.; Bergfeld, T.; Eisenstein, B.I.; Ernst, J.; Gladding, G.E.; Gollin, G.D.; Palmer, M.; Selen, M.; Thaler, J.J.; Edwards, K.W.; McLean, K.W.; Ogg, M.; Bellerive, A.; Britton, D.I.; Hyatt, E.R.; Janicek, R.; MacFarlane, D.B.; Patel, P.M.; Spaan, B.; Sadoff, A.J.; Ammar, R.; Baringer, P.; Bean, A.; Besson, D.; Coppage, D.; Copty, N.; Davis, R.; Hancock, N.; Kotov, S.; Kravchenko, I.; Kwak, N.; Kubota, Y.; Lattery, M.; Momayezi, M.; Nelson, J.K.; Patton, S.; Poling, R.; Savinov, V.; Schrenk, S.; Wang, R.; Alam, M.S.; Kim, I.J.; Ling, Z.; Mahmood, A.H.; ONeill, J.J.; Severini, H.; Sun, C.R.; Wappler, F.; Crawford, G.; Fulton, R.; Fujino, D.; Gan, K.K.; Honscheid, K.; Kagan, H.; Kass, R.; Lee, J.; Sung, M.; White, C.; Wolf, A.; Zoeller, M.M.; Fu, X.; Nemati, B.; Ross, W.R.; Skubic, P.; Wood, M.; Bishai, M.; Fast, J.; Gerndt, E.; Hinson, J.W.; Miao, T.; Miller, D.H.; Modesitt, M.; Shibata, E.I.; Shipsey, I.P.; Wang, P.N.; Gibbons, L.; Johnson, S.D.; Kwon, Y.; Roberts, S.; Thorndike, E.H.; Coan, T.E.; Dominick, J.; Fadeyev, V.; Korolkov, I.; Lambrecht, M.; Sanghera, S.; Shelkov, V.; Skwarnicki, T.; Stroynowski, R.; Volobouev, I.; Wei, G.; Artuso, M.; Gao, M.; Goldberg, M.; He, D.; Horwitz, N.; Kopp, S.; Moneti, G.C.; Mountain, R.; Muheim, F.; Mukhin, Y.; Playfer, S.

    1996-02-01

    We report the observation of the Cabibbo-suppressed decays {Lambda}{sub {ital c}}{sup +}{r_arrow}{ital pK{sup {minus}}K{sup +}} and {Lambda}{sub {ital c}}{sup +}{r_arrow}{ital p}{phi} using data collected with the CLEO II detector at CESR. The latter mode, observed for the first time with significant statistics, is of interest as a test of color suppression in charm decays. We have determined the branching ratios for these modes relative to {Lambda}{sub {ital c}}{sup +}{r_arrow}{ital pK{sup {minus}}}{pi}{sup +} and compared our results with theory. {copyright} {ital 1996 The American Physical Society.}

  18. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK

    SciTech Connect (OSTI)

    Li, Ying; Li, Jia; Li, Shanshan; Li, Yi; Wang, Xiangxiang; Liu, Baolin; Fu, Qiang; Ma, Shiping

    2015-07-01

    Curcumin is a natural polyphenolic compound in Curcuma longa with beneficial effects on neuronal protection. This study aims to investigate the action of curcumin in the hippocampus subjected to glutamate neurotoxicity. Glutamate stimulation induced reactive oxygen species (ROS), endoplasmic reticulum stress (ER stress) and TXNIP/NLRP3 inflammasome activation, leading to damage in the hippocampus. Curcumin treatment in the hippocampus or SH-SY5Y cells inhibited IRE1α and PERK phosphorylation with suppression of intracellular ROS production. Curcumin increased AMPK activity and knockdown of AMPKα with specific siRNA abrogated its inhibitory effects on IRE1α and PERK phosphorylation, indicating that AMPK activity was essential for the suppression of ER stress. As a result, curcumin reduced TXNIP expression and inhibited NLRP3 inflammasome activation by downregulation of NLRP3 and cleaved caspase-1 induction, and thus reduced IL-1β secretion. Specific fluorescent probe and flow cytometry analysis showed that curcumin prevented mitochondrial malfunction and protected cell survival from glutamate neurotoxicity. Moreover, oral administration of curcumin reduced brain infarct volume and attenuated neuronal damage in rats subjected to middle cerebral artery occlusion. Immunohistochemistry showed that curcumin inhibited p-IRE1α, p-PERK and NLRP3 expression in hippocampus CA1 region. Together, these results showed that curcumin attenuated glutamate neurotoxicity by inhibiting ER stress-associated TXNIP/NLRP3 inflammasome activation via the regulation of AMPK, and thereby protected the hippocampus from ischemic insult. - Highlights: • Curcumin attenuates glutamate neurotoxicity in the hippocampus. • Curcumin suppresses ER stress in glutamate-induced hippocampus slices. • Curcumin inhibits TXNIP/NLRP3 inflammasome activation. • Regulation of AMPK by curcumin contributes to suppressing ER stress.

  19. Apigenin suppresses migration and invasion of transformed cells through down-regulation of C-X-C chemokine receptor 4 expression

    SciTech Connect (OSTI)

    Wang, Lei; Kuang, Lisha; Hitron, John Andrew; Son, Young-Ok; Wang, Xin; Budhraja, Amit; Lee, Jeong-Chae; Pratheeshkumar, Poyil; Chen, Gang; Zhang, Zhuo; Luo, Jia; Shi, Xianglin

    2013-10-01

    Environmental exposure to arsenic is known to cause various cancers. There are some potential relationships between cell malignant transformation and C-X-C chemokine receptor type 4 (CXCR4) expressions. Metastasis, one of the major characteristics of malignantly transformed cells, contributes to the high mortality of cells. CXCR4 and its natural chemokine ligand C-X-C motif ligand 12 (CXCL12) play a critical role in metastasis. Therefore, identification of nutritional factors which are able to inhibit CXCR4 is important for protection from environmental arsenic-induced carcinogenesis and for abolishing metastasis of malignantly transformed cells. The present study demonstrates that apigenin (4′,5,7-trihydroxyflavone), a natural dietary flavonoid, suppressed CXCR4 expression in arsenic-transformed Beas-2B cells (B-AsT) and several other types of transformed/cancer cells in a dose- and time-dependent manner. Neither proteasome nor lysosome inhibitor had any effect in reducing the apigenin-induced down-regulation of CXCR4, indicating that apigenin-induced down-regulation of CXCR4 is not due to proteolytic degradation. The down-regulation of CXCR4 is mainly due to the inhibition of nuclear factor κB (NF-κB) transcriptional activity. Apigenin also abolished migration and invasion of transformed cells induced by CXCL12. In a xenograft mouse model, apigenin down-regulated CXCR4 expression and suppressed tumor growth. Taken together, our results show that apigenin is a novel inhibitor of CXCR4 expression. This dietary flavonoid has the potential to suppress migration and invasion of transformed cells and prevent environmental arsenic-induced carcinogenesis. - Highlights: • Apigenin has a potential in preventing environmental arsenic induced carcinogenesis. • Apigenin suppresses CXCR4 in malignant transformed cells in vitro and in vivo. • The down-regulation of CXCR4 is mainly due to inhibition of NF-κB activity.

  20. A non-uniform three-gap buncher cavity with suppression of transverse-electromagnetic mode leakage in the triaxial klystron amplifier

    SciTech Connect (OSTI)

    Qi, Zumin; Zhang, Jun Zhong, Huihuang; Zhu, Danni; Qiu, Yongfeng

    2014-01-15

    The triaxial klystron amplifier is an efficient high power relativistic klystron amplifier operating at high frequencies due to its coaxial structure with large radius. However, the coaxial structures result in coupling problems among the cavities as the TEM mode is not cut-off in the coaxial tube. Therefore, the suppression of the TEM mode leakage, especially the leakage from the buncher cavity to the input cavity, is crucial in the design of a triaxial klystron amplifier. In this paper, a non-uniform three-gap buncher cavity is proposed to suppress the TEM mode leakage. The cold cavity analysis shows that the non-uniform three-gap buncher cavity can significantly suppress the TEM mode generation compared to a uniform three-gap buncher cavity. Particle-in-cell simulation shows that the power leakage to the input cavity is less than 1.5 of the negative power in the buncher cavity and the buncher cavity can efficiently modulate an intense relativistic electron beam free of self-oscillations. A fundamental current modulation depth of 117% is achieved by employing the proposed non-uniform buncher cavity into an X-band triaxial amplifier, which results in the high efficiency generation of high power microwave.

  1. Signal Processing System for the CASA Integrated Project I Radars

    SciTech Connect (OSTI)

    Bharadwaj, Nitin; Chandrasekar, V.; Junyent, Francesc

    2010-09-01

    This paper describes the waveform design space and signal processing system for dual-polarization Doppler weather radar operating at X band. The performance of the waveforms is presented with ground clutter suppression capability and mitigation of range velocity ambiguity. The operational waveform is designed based on operational requirements and system/hardware requirements. A dual Pulse Repetition Frequency (PRF) waveform was developed and implemented for the first generation X-band radars deployed by the Center for Collaborative Adaptive Sensing of the Atmosphere (CASA). This paper presents an evaluation of the performance of the waveforms based on simulations and data collected by the first-generation CASA radars during operations.

  2. File Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    File Systems File Systems For a general description of the different file systems available on PDSF please see Eliza File Systems and Other File Systems. Below is a summary of how ALICE uses the various systems: /common ALICE uses /common to build the software that supports its grid-based automated production work. This software includes AliRoot, Geant, AliEn, and XRootD. /eliza6, /eliza8, /eliza17 ALICE has space on 3 elizas: 16TB on /eliza6, 6TB on /eliza8 and 11TB on /eliza17. The space on

  3. File Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    File Systems File Systems For a general description of the different file systems available on PDSF please see Eliza File Systems and Other File Systems. Below is a summary of how STAR uses the various systems: /common The STAR software is installed on /common. For 32sl44 it is under /common/star/star44 and for sl53 it is under /common/star/star53. In both cases the software consists primarily of a STAR-specific ROOT installation on which releases of the STAR libraries are built as shown on the

  4. Files systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Files systems Files systems NERSC's global home and project file systems are available on Franklin. Additionally, Franklin has over 400 TB of locally attached high-performance /scratch disk space For information on the NERSC file systems, see the link at right. Scratch File Systems Size Aggregate Peak Performance # IO Servers Interconnect File System Software Disk Array Vendor $SCRATCH 209 TB 17 GB/sec 24 Lustre DDN $SCRATCH2 209 TB 17 GB/sec 24 Lustre DDN SCRATCH and SCRATCH2 There are two

  5. Suppression of alkylating agent induced cell transformation and gastric ulceration by low-dose alkylating agent pretreatment

    SciTech Connect (OSTI)

    Onodera, Akira; Department of Pharmaceutical Sciences, Kobegakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe 650-8586 ; Kawai, Yuichi; Kashimura, Asako; Ogita, Fumiya; Tsutsumi, Yasuo; Itoh, Norio

    2013-06-14

    Highlights: Low-dose MNNG pretreatment suppresses high-dose MNNG induced in vitro transformation. Gastric ulcers induced by high-dose MNNG decreased after low-dose MNNG pretreatment. Efficacy of low-dose MNNG related to resistance of mutation and oxidative stress. -- Abstract: Exposure to mild stress by chemicals and radiation causes DNA damage and leads to acquired stress resistance. Although the linear no-threshold (LNT) model of safety assessment assumes risk from any dose, evidence from radiological research demonstrates a conflicting hormetic phenomenon known as the hormesis effect. However, the mechanisms underlying radiation hormesis have not yet been clarified, and little is known about the effects of low doses of chemical carcinogens. We analyzed the efficacy of pretreatment with low doses of the alkylating agent N-methyl-N?-nitro-N-nitrosoguanidine (MNNG) on the subsequent induction of cell transformation and gastric ulceration by high-dose MNNG. We used an in vitro Balb/3T3 A31-1-1 cell transformation test and monitored the formation of gastric ulcers in 5-week-old male ICR mice that were administered MNNG in drinking water. The treatment concentrations of MNNG were determined by the cell survival rate and past reports. For low-dose in vitro and in vivo experiments, MNNG was used at 0.028 ?M, and 2.8 ?g/mL, respectively. The frequency of cell transformation induced by 10 ?m MNNG was decreased by low-dose MNNG pretreatment to levels similar to that of spontaneous transformation. In addition, reactive oxygen species (ROS) and mutation frequencies induced by 10 ?m MNNG were decreased by low-dose MNNG pretreatment. Importantly, low-dose MNNG pretreatment had no effect on cell proliferation. In vivo studies showed that the number of gastric ulcers induced by 1 mg/mL MNNG decreased after low-dose MNNG pretreatment. These data indicate that low-dose pretreatment with carcinogens may play a beneficial role in the prevention of chemical toxicity under specified conditions.

  6. Ammonia-Free NOx Control System

    SciTech Connect (OSTI)

    Zhen Fan; Song Wu; Richard G. Herman

    2004-06-30

    Research is being conducted under United States Department of Energy (DOE) Contract DEFC26-03NT41865 to develop a new technology to achieve very low levels of NOx emissions from pulverized coal fired boiler systems by employing a novel system level integration between the PC combustion process and the catalytic NOx reduction with CO present in the combustion flue gas. The combustor design and operating conditions will be optimized to achieve atypical flue gas conditions. This approach will not only suppress NOx generation during combustion but also further reduce NOx over a downstream catalytic reactor that does not require addition of an external reductant, such as ammonia. This report describes the work performed during the April 1 to June 30, 2004 time period.

  7. Multiple channel data acquisition system

    DOE Patents [OSTI]

    Crawley, H. Bert; Rosenberg, Eli I.; Meyer, W. Thomas; Gorbics, Mark S.; Thomas, William D.; McKay, Roy L.; Homer, Jr., John F.

    1990-05-22

    A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler.

  8. Multiple channel data acquisition system

    DOE Patents [OSTI]

    Crawley, H.B.; Rosenberg, E.I.; Meyer, W.T.; Gorbics, M.S.; Thomas, W.D.; McKay, R.L.; Homer, J.F. Jr.

    1990-05-22

    A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler. 25 figs.

  9. System Effectiveness

    SciTech Connect (OSTI)

    Powell, Danny H; Elwood Jr, Robert H

    2011-01-01

    An effective risk assessment system is needed to address the threat posed by an active or passive insider who, acting alone or in collusion, could attempt diversion or theft of nuclear material. It is critical that a nuclear facility conduct a thorough self-assessment of the material protection, control, and accountability (MPC&A) system to evaluate system effectiveness. Self-assessment involves vulnerability analysis and performance testing of the MPC&A system. The process should lead to confirmation that mitigating features of the system effectively minimize the threat, or it could lead to the conclusion that system improvements or upgrades are necessary to achieve acceptable protection against the threat. Analysis of the MPC&A system is necessary to understand the limits and vulnerabilities of the system to internal threats. Self-assessment helps the facility be prepared to respond to internal threats and reduce the risk of theft or diversion of nuclear material. MSET is a self-assessment or inspection tool utilizing probabilistic risk assessment (PRA) methodology to calculate the system effectiveness of a nuclear facility's MPC&A system. MSET analyzes the effectiveness of an MPC&A system based on defined performance metrics for MPC&A functions based on U.S. and international best practices and regulations. A facility's MC&A system can be evaluated at a point in time and reevaluated after upgrades are implemented or after other system changes occur. The total system or specific subareas within the system can be evaluated. Areas of potential performance improvement or system upgrade can be assessed to determine where the most beneficial and cost-effective improvements should be made. Analyses of risk importance factors show that sustainability is essential for optimal performance. The analyses reveal where performance degradation has the greatest detrimental impact on total system risk and where performance improvements have the greatest reduction in system risk. The risk importance factors show the amount of risk reduction achievable with potential upgrades and the amount of risk reduction actually achieved after upgrades are completed. Applying the risk assessment tool gives support to budget prioritization by showing where budget support levels must be sustained for MC&A functions most important to risk. Results of the risk assessment are also useful in supporting funding justifications for system improvements that significantly reduce system risk.

  10. Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging

    SciTech Connect (OSTI)

    Yeh, Chi-Tai; Center of Excellence for Cancer Research, Taipei Medical University, Taipei, Taiwan; Department of Surgery, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan ; Rao, Yerra Koteswara; Ye, Min; Wu, Wen-Shi; Chang, Tung-Chen; Wang, Liang-Shun; Division of Thoracic Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan ; Wu, Chih-Hsiung; Department of Surgery, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan ; Wu, Alexander T.H.; Tzeng, Yew-Min

    2012-05-15

    In continuation to our studies toward the identification of direct anti-cancer targets, here we showed that destruxin B (DB) from Metarhizium anisopliae suppressed the proliferation and induced cell cycle arrest in human colorectal cancer (CRC) HT29, SW480 and HCT116 cells. Additionally, DB induced apoptosis in HT29 cells by decreased expression level of anti-apoptotic proteins Bcl-2 and Bcl-xL while increased pro-apoptotic Bax. On the other hand, DB attenuated Wnt-signaling by downregulation of ?-catenin, Tcf4 and ?-catenin/Tcf4 transcriptional activity, concomitantly with decreased expression of ?-catenin target genes cyclin D1, c-myc and survivin. Furthermore, DB affected the migratory and invasive ability of HT29 cells through suppressed MMPs-2 and -9 enzymatic activities. We also found that DB targeted the MAPK and/or PI3K/Akt pathway by reduced expression of Akt, IKK-?, JNK, NF-?B, c-Jun and c-Fos while increased that of I?B?. Finally, we demonstrated that DB inhibited tumorigenesis in HT29 xenograft mice using non-invasive bioluminescence technique. Consistently, tumor samples from DB-treated mice demonstrated suppressed expression of ?-catenin, cyclin D1, survivin, and endothelial marker CD31 while increased caspase-3 expression. Collectively, our data supports DB as an inhibitor of Wnt/?-catenin/Tcf signaling pathway that may be beneficial in the CRC management. Highlights: ? Destruxin B (DB) inhibited colorectal cancer cells growth and induced apoptosis. ? MAPK and/or PI3K/Akt cascade cooperates in DB induced apoptosis. ? DB affected the migratory and invasive ability of HT29 cells through MMP-9. ? DB attenuated Wnt-signaling components ?-catenin, Tcf4. ? DB attenuated cyclin D1, c-myc, survivin and tumorigenesis in HT29 xenograft mice.

  11. Temperature System

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    1 Soil Water and Temperature System  SWATS In the realm of global climate modeling, numerous variables affect the state of the atmosphere and climate. One important area is soil moisture and temperature. The ARM Program uses several types of instruments to gather soil moisture information. An example is the soil water and temperature system (SWATS) (Figure 1). A SWATS is located at each of 21 extended facility sites within the CART site boundary. Each system is configured to measure soil

  12. CALUTRON SYSTEM

    DOE Patents [OSTI]

    Lawrence, E.O.

    1958-08-12

    A calutron system capable of functioning with only a portion of the separation tanks in the system operating is described. The invention is a calutron system comprssing a closed series of alternated tanks and electromagnets having a mid-yoke connecting intermediate positions of the series. dividing the series into twv-o portions, and thereby providing a closed magnetic path through either of the portions.

  13. Suppression of roll-off characteristics of organic light-emitting diodes by narrowing current injection/transport area to 50?nm

    SciTech Connect (OSTI)

    Hayashi, Kyohei Inoue, Munetomo; Yoshida, Kou; Nakanotani, Hajime; Mikhnenko, Oleksandr; Nguyen, Thuc-Quyen E-mail: adachi@cstf.kyushu-u.ac.jp; Adachi, Chihaya E-mail: adachi@cstf.kyushu-u.ac.jp

    2015-03-02

    Using e-beam nanolithography, the current injection/transport area in organic light-emitting diodes (OLEDs) was confined into a narrow linear structure with a minimum width of 50?nm. This caused suppression of Joule heating and partial separation of polarons and excitons, so the charge density where the electroluminescent efficiency decays to the half of the initial value (J{sub 0}) was significantly improved. A device with a narrow current injection width of 50?nm exhibited a J{sub 0} that was almost two orders of magnitude higher compared with that of the unpatterned OLED.

  14. Activation of peroxisome proliferator-activated receptor-{alpha} (PPAR{alpha}) suppresses postprandial lipidemia through fatty acid oxidation in enterocytes

    SciTech Connect (OSTI)

    Kimura, Rino; Takahashi, Nobuyuki; Murota, Kaeko; Yamada, Yuko; Niiya, Saori; Kanzaki, Noriyuki; Murakami, Yoko; Moriyama, Tatsuya; Goto, Tsuyoshi; Kawada, Teruo

    2011-06-24

    Highlights: {yields} PPAR{alpha} activation increased mRNA expression levels of fatty acid oxidation-related genes in human intestinal epithelial Caco-2 cells. {yields} PPAR{alpha} activation also increased oxygen consumption rate and CO{sub 2} production and decreased secretion of triglyceride and ApoB from Caco-2 cells. {yields} Orally administration of bezafibrate increased mRNA expression levels of fatty acid oxidation-related genes and CO{sub 2} production in small intestinal epithelial cells. {yields} Treatment with bezafibrate decreased postprandial serum concentration of triglyceride after oral injection of olive oil in mice. {yields} It suggested that intestinal lipid metabolism regulated by PPAR{alpha} activation suppresses postprandial lipidemia. -- Abstract: Activation of peroxisome proliferator-activated receptor (PPAR)-{alpha} which regulates lipid metabolism in peripheral tissues such as the liver and skeletal muscle, decreases circulating lipid levels, thus improving hyperlipidemia under fasting conditions. Recently, postprandial serum lipid levels have been found to correlate more closely to cardiovascular diseases than fasting levels, although fasting hyperlipidemia is considered an important risk of cardiovascular diseases. However, the effect of PPAR{alpha} activation on postprandial lipidemia has not been clarified. In this study, we examined the effects of PPAR{alpha} activation in enterocytes on lipid secretion and postprandial lipidemia. In Caco-2 enterocytes, bezafibrate, a potent PPAR{alpha} agonist, increased mRNA expression levels of fatty acid oxidation-related genes, such as acyl-CoA oxidase, carnitine palmitoyl transferase, and acyl-CoA synthase, and oxygen consumption rate (OCR) and suppressed secretion levels of both triglycerides and apolipoprotein B into the basolateral side. In vivo experiments revealed that feeding high-fat-diet containing bezafibrate increased mRNA expression levels of fatty acid oxidation-related genes and production of CO{sub 2} and acid soluble metabolites in enterocytes. Moreover, bezafibrate treatment suppressed postprandial lipidemia after oral administration of olive oil to the mice. These findings indicate that PPAR{alpha} activation suppresses postprandial lipidemia through enhancement of fatty acid oxidation in enterocytes, suggesting that intestinal lipid metabolism regulated by PPAR{alpha} activity is a novel target of PPAR{alpha} agonist for decreasing circulating levels of lipids under postprandial conditions.

  15. MicroRNA-101 mediates the suppressive effect of laminar shear stress on mTOR expression in vascular endothelial cells

    SciTech Connect (OSTI)

    Chen, Kui; Fan, Wendong; Wang, Xing; Ke, Xiao [Division of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080 (China)] [Division of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080 (China); Wu, Guifu, E-mail: eecpchina@yahoo.com.cn [Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080 (China)] [Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou 510080 (China); Hu, Chengheng, E-mail: huchenghengpci@yahoo.com.cn [Division of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080 (China)] [Division of Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080 (China)

    2012-10-12

    Highlights: Black-Right-Pointing-Pointer Laminar shear stress upregulates miR-101 expression in vascular endothelial cells. Black-Right-Pointing-Pointer miR-101 represses mTOR expression through a specific 3 Prime UTR binding site. Black-Right-Pointing-Pointer Overexpression of miR-101 inhibits G1/S transition and endothelial cell proliferation. Black-Right-Pointing-Pointer Blockade of miR-101 attenuates the suppressive effect of laminar flow on mTOR expression. -- Abstract: Shear stress associated with blood flow plays an important role in regulating gene expression and cell function in endothelial cells (ECs). MicroRNAs (miRNAs) are highly conserved, small non-coding RNAs that negatively regulate the expression of target genes by binding to the mRNA 3 Prime -untranslated region (3 Prime UTR) at the posttranscriptional level involved in diverse cellular processes. This study demonstrates that microRNA-101 in response to laminar shear stress (LSS) is involved in the flow regulation of gene expression in ECs. qRT-PCR analysis showed that miR-101 expression was significantly upregulated in human umbilical vein endothelial cells (HUVECs) exposed to 12 dyn/cm{sup 2} laminar shear stress for 12 h. We found that transfection of miR-101 significantly decreased the luciferase activity of plasmid reporter containing the 3 Prime UTR of mammalian target of rapamycin (mTOR) gene. Western analysis revealed that the protein level of mTOR was significantly reduced in ECs transfected with miR-101. Furthermore, miR-101 overexpression induced cell cycle arrest at the G1/S transition and suppressed endothelial cell proliferation. Finally, transfection of miR-101 inhibitors attenuated the suppressive effects of LSS on mTOR expression, which identified the efficacy of loss-of-function of miR-101 in laminar flow-treated ECs. In conclusion, we have demonstrated that upregulation of miR-101 in response to LSS contributes to the suppressive effects of LSS on mTOR expression and EC proliferation. These studies advance our understanding of the posttranscriptional mechanisms by which shear stress modulates endothelial homeostasis.

  16. * Systems update

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    update * Edison update * NUG annual meeting * Queues and System Usage * User Survey results * Data ... - 21016 2015, Energy Sciences Network The Central ...

  17. Power system

    DOE Patents [OSTI]

    Hickam, Christopher Dale

    2008-03-18

    A power system includes a prime mover, a transmission, and a fluid coupler having a selectively engageable lockup clutch. The fluid coupler may be drivingly connected between the prime mover and the transmission. Additionally, the power system may include a motor/generator drivingly connected to at least one of the prime mover and the transmission. The power-system may also include power-system controls configured to execute a control method. The control method may include selecting one of a plurality of modes of operation of the power system. Additionally, the control method may include controlling the operating state of the lockup clutch dependent upon the mode of operation selected. The control method may also include controlling the operating state of the motor/generator dependent upon the mode of operation selected.

  18. InGaN/GaN multiple-quantum-well light-emitting diodes with a grading InN composition suppressing the Auger recombination

    SciTech Connect (OSTI)

    Zhang, Zi-Hui; Liu, Wei; Ju, Zhengang; Tan, Swee Tiam; Ji, Yun; Kyaw, Zabu; Zhang, Xueliang; Wang, Liancheng; Sun, Xiao Wei E-mail: VOLKAN@stanfordalumni.org; Demir, Hilmi Volkan E-mail: VOLKAN@stanfordalumni.org

    2014-07-21

    In conventional InGaN/GaN light-emitting diodes (LEDs), thin InGaN quantum wells are usually adopted to mitigate the quantum confined Stark effect (QCSE), caused due to strong polarization induced electric field, through spatially confining electrons and holes in small recombination volumes. However, this inevitably increases the carrier density in quantum wells, which in turn aggravates the Auger recombination, since the Auger recombination scales with the third power of the carrier density. As a result, the efficiency droop of the Auger recombination severely limits the LED performance. Here, we proposed and showed wide InGaN quantum wells with the InN composition linearly grading along the growth orientation in LED structures suppressing the Auger recombination and the QCSE simultaneously. Theoretically, the physical mechanisms behind the Auger recombination suppression are also revealed. The proposed LED structure has experimentally demonstrated significant improvement in optical output power and efficiency droop, proving to be an effective solution to this important problem of Auger recombination.

  19. Observation of the large magnetocaloric effect and suppression of orbital entropy change in Fe-doped MnV{sub 2}O{sub 4}

    SciTech Connect (OSTI)

    Huang, Z. H.; Luo, X. E-mail: ypsun@issp.ac.cn; Hu, L.; Tan, S. G.; Liu, Y.; Yuan, B.; Chen, J.; Song, W. H.; Sun, Y. P. E-mail: ypsun@issp.ac.cn

    2014-01-21

    We present the structural and magnetic properties of Mn{sub 1−x}Fe{sub x}V{sub 2}O{sub 4} (x = 0.1, 0.2, and 0.3), and investigate the magnetocaloric effect in those compounds. The ferrimagnetic spin ordering is enhanced with the Fe doping at Mn site of MnV{sub 2}O{sub 4}, while the orbital ordering is suppressed. Large magnetic entropy changes up to 3.8 J/kg K as well as the relative cooling power up to 110 J/kg at the field change of 0-2 T for Mn{sub 1−x}Fe{sub x}V{sub 2}O{sub 4} are calculated from the isothermal magnetization measurements. The large orbital entropy change of MnV{sub 2}O{sub 4} is suppressed by the Fe doping, while the spin entropy contribution arising from the strong spin-orbit coupling remains. Moreover, the doping of Fe broadens the temperature span of the large magnetic entropy change and increases the relative cooling power of MnV{sub 2}O{sub 4} by 2.4 times.

  20. Pressure Effect on the Structural Transition and Suppression of the High-Spin State in the Triple-Layer T'-La₄Ni₃O₈

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Cheng, J.-G.; Zhou, J.-S.; Goodenough, J. B.; Zhou, H. D.; Matsubayashi, K.; Uwatoko, Y.; Kong, P. P.; Jin, C. Q.; Yang, W. G.; Shen, G. Y.

    2012-06-08

    We report a comprehensive high-pressure study on the triple-layer T'-La₄Ni₃O₈ with a suite of experimental probes, including structure determination, magnetic, and transport properties up to 50 GPa. Consistent with a recent ab inito calculation, application of hydrostatic pressure suppresses an insulator-metal spin-state transition at Pc≈6 GPa. However, a low-spin metallic phase does not emerge after the high-spin state is suppressed to the lowest temperature. For P>20 GPa, the ambient T' structure transforms gradually to a T†-type structure, which involves a structural reconstruction from fluorite La–O₂–La blocks under low pressures to rock-salt LaO-LaO blocks under high pressures. Absence of the metallicmore » phase under pressure has been discussed in terms of local displacements of O²⁻ ions in the fluorite block under pressure before a global T† phase is established.« less

  1. Pressure Effect on the Structural Transition and Suppression of the High-Spin State in the Triple-Layer T'-La?Ni?O?

    SciTech Connect (OSTI)

    Cheng, J.-G.; Zhou, J.-S.; Goodenough, J. B.; Zhou, H. D.; Matsubayashi, K.; Uwatoko, Y.; Kong, P. P.; Jin, C. Q.; Yang, W. G.; Shen, G. Y.

    2012-06-08

    We report a comprehensive high-pressure study on the triple-layer T'-La?Ni?O? with a suite of experimental probes, including structure determination, magnetic, and transport properties up to 50 GPa. Consistent with a recent ab inito calculation, application of hydrostatic pressure suppresses an insulator-metal spin-state transition at Pc?6 GPa. However, a low-spin metallic phase does not emerge after the high-spin state is suppressed to the lowest temperature. For P>20 GPa, the ambient T' structure transforms gradually to a T-type structure, which involves a structural reconstruction from fluorite LaO?La blocks under low pressures to rock-salt LaO-LaO blocks under high pressures. Absence of the metallic phase under pressure has been discussed in terms of local displacements of O? ions in the fluorite block under pressure before a global T phase is established.

  2. Electronic system

    DOE Patents [OSTI]

    Robison, G H; Dickson, J F

    1960-11-15

    An electronic system is designed for indicating the occurrence of a plurality of electrically detectable events within predetermined time intervals. The system comprises separate input means electrically associated with the events under observation an electronic channel associated with each input means, including control means and indicating means; timing means adapted to apply a signal from the input means after a predetermined time to the control means to deactivate each of the channels; and means for resetting the system to its initial condition after the observation of each group of events. (D.L.C.)

  3. Degradation of Nylon 6,6 Fire-Suppression Casing from Plutonium Glove Boxes Under Alpha and Neutron Irradiation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Millsap, Donald W.; Cournoyer, Michael E.; Landsberger, Sheldon; Tesmer, Joseph R.; Wang, Matthew Y.

    2015-04-23

    Nylon 6,6 tensile specimens, conforming to the casing for self-contained fire extinguisher systems, have been irradiated using both an accelerator He++ ion beam and a 5-Ci PuBe neutron source to model the radiation damage these systems would likely incur over a lifetime of operation within glove boxes. Following irradiation, these samples were mechanically tested using standard practices as described in ASTM D638. The results of the He++ study indicate that the tensile strength of the nylon specimens undergoes some slight (<10%) degradation while other properties of the samples, such as elongation and tangent modulus, appear to fluctuate with increasing dosemore » levels. The He++-irradiated specimens also have a noticeable level of discoloration corresponding to increasing levels of dose. The neutron-irradiated samples show a higher degree of mechanical degradation than the He++-irradiated samples.« less

  4. SAMPLING SYSTEM

    DOE Patents [OSTI]

    Hannaford, B.A.; Rosenberg, R.; Segaser, C.L.; Terry, C.L.

    1961-01-17

    An apparatus is given for the batch sampling of radioactive liquids such as slurries from a system by remote control, while providing shielding for protection of operating personnel from the harmful effects of radiation.

  5. Battery system

    DOE Patents [OSTI]

    Dougherty, Thomas J; Wood, Steven J; Trester, Dale B; Andrew, Michael G

    2013-08-27

    A battery module includes a plurality of battery cells and a system configured for passing a fluid past at least a portion of the plurality of battery cells in a parallel manner.

  6. Accelerator Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Accelerator Systems Accelerator Systems MaRIE will provide a capability to address the control of performance and production of weapons materials at the mesoscale. MaRIE fills a critical gap in length scale between the integral scale addressed by studies conducted at DARHT, U1a, NIF, and Z. CONTACT Richard Sheffield (505) 667-1237 Email Revolutionizing Microstructural Physics to Empower Nuclear Energy Realizing MaRIE's full suite of capabilities requires developing and integrating a suite of

  7. Systems Studies

    SciTech Connect (OSTI)

    Graham, R.L.

    1998-03-17

    The Systems Studies Activity had two objectives: (1) to investigate nontechnical barriers to the deployment of biomass production and supply systems and (2) to enhance and extend existing systems models of bioenergy supply and use. For the first objective, the Activity focused on existing bioenergy markets. Four projects were undertaken: a comparative analysis of bioenergy in Sweden and Austria; a one-day workshop on nontechnical barriers jointly supported by the Production Systems Activity; the development and testing of a framework for analyzing barriers and drivers to bioenergy markets; and surveys of wood pellet users in Sweden, Austria and the US. For the second objective, two projects were undertaken. First, the Activity worked with the Integrated BioEnergy Systems (TBS) Activity of TEA Bioenergy Task XIII to enhance the BioEnergy Assessment Model (BEAM). This model is documented in the final report of the IBS Activity. The Systems Studies Activity contributed to enhancing the feedstock portion of the model by developing a coherent set of willow, poplar, and switchgrass production modules relevant to both the US and the UK. The Activity also developed a pretreatment module for switchgrass. Second, the Activity sponsored a three-day workshop on modeling bioenergy systems with the objectives of providing an overview of the types of models used to evaluate bioenergy and promoting communication among bioenergy modelers. There were nine guest speakers addressing different types of models used to evaluate different aspects of bioenergy, ranging from technoeconomic models based on the ASPEN software to linear programming models to develop feedstock supply curves for the US. The papers from this workshop have been submitted to Biomass and Bioenergy and are under editorial review.

  8. Anticancer effect of genistein on BG-1 ovarian cancer growth induced by 17 ?-estradiol or bisphenol A via the suppression of the crosstalk between estrogen receptor alpha and insulin-like growth factor-1 receptor signaling pathways

    SciTech Connect (OSTI)

    Hwang, Kyung-A; Park, Min-Ah; Kang, Nam-Hee; Yi, Bo-Rim; Hyun, Sang-Hwan; Jeung, Eui-Bae; Choi, Kyung-Chul

    2013-11-01

    The interaction between estrogen receptor (ER) and insulin-like growth factor-1 receptor (IGF-1R) signaling pathway plays an important role in proliferation of and resistance to endocrine therapy to estrogen dependent cancers. Estrogen (E2) upregulates the expression of components of IGF-1 system and induces the downstream of mitogenic signaling cascades via phosphorylation of insulin receptor substrate-1 (IRS-1). In the present study, we evaluated the xenoestrogenic effect of bisphenol A (BPA) and antiproliferative activity of genistein (GEN) in accordance with the influence on this crosstalk. BPA was determined to affect this crosstalk by upregulating mRNA expressions of ER? and IGF-1R and inducing phosphorylation of IRS-1 and Akt in protein level in BG-1 ovarian cancer cells as E2 did. In the mouse model xenografted with BG-1 cells, BPA significantly increased a tumor burden of mice and expressions of ER?, pIRS-1, and cyclin D1 in tumor mass compared to vehicle, indicating that BPA induces ovarian cancer growth by promoting the crosstalk between ER and IGF-1R signals. On the other hand, GEN effectively reversed estrogenicity of BPA by reversing mRNA and protein expressions of ER?, IGF-1R, pIRS-1, and pAkt induced by BPA in cellular model and also significantly decreased tumor growth and in vivo expressions of ER?, pIRS-1, and pAkt in xenografted mouse model. Also, GEN was confirmed to have an antiproliferative effect by inducing apoptotic signaling cascades. Taken together, these results suggest that GEN effectively reversed the increased proliferation of BG-1 ovarian cancer by suppressing the crosstalk between ER? and IGF-1R signaling pathways upregulated by BPA or E2.

  9. ELECTRONIC SYSTEM

    DOE Patents [OSTI]

    Robison, G.H. et al.

    1960-11-15

    An electronic system is described for indicating the occurrence of a plurality of electrically detectable events within predetermined time intervals. It is comprised of separate input means electrically associated with the events under observation: an electronic channel associated with each input means including control means and indicating means; timing means associated with each of the input means and the control means and adapted to derive a signal from the input means and apply it after a predetermined time to the control means to effect deactivation of each of the channels; and means for resetting the system to its initial condition after observation of each group of events.

  10. Systems Modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    You are here Home » Systems Integration Systems Integration Hawaii DREAMS of New Solar Technologies Hawaii DREAMS of New Solar Technologies Read more Plug and Play Solar PV for American Homes Plug and Play Solar PV for American Homes Read more Watt-Sun: A Multi-Scale, Multi-Modal, Machine-Learning Solar Forecasting Technology Watt-Sun: A Multi-Scale, Multi-Modal, Machine-Learning Solar Forecasting Technology Read more High PV Penetration with Energy Storage in Flagstaff, AZ High PV Penetration

  11. Emergency cooling system and method

    DOE Patents [OSTI]

    Oosterkamp, W.J.; Cheung, Y.K.

    1994-01-04

    An improved emergency cooling system and method are disclosed that may be adapted for incorporation into or use with a nuclear BWR wherein a reactor pressure vessel (RPV) containing a nuclear core and a heat transfer fluid for circulation in a heat transfer relationship with the core is housed within an annular sealed drywell and is fluid communicable therewith for passage thereto in an emergency situation the heat transfer fluid in a gaseous phase and any noncondensibles present in the RPV, an annular sealed wetwell houses the drywell, and a pressure suppression pool of liquid is disposed in the wetwell and is connected to the drywell by submerged vents. The improved emergency cooling system and method has a containment condenser for receiving condensible heat transfer fluid in a gaseous phase and noncondensibles for condensing at least a portion of the heat transfer fluid. The containment condenser has an inlet in fluid communication with the drywell for receiving heat transfer fluid and noncondensibles, a first outlet in fluid communication with the RPV for the return to the RPV of the condensed portion of the heat transfer fluid and a second outlet in fluid communication with the drywell for passage of the noncondensed balance of the heat transfer fluid and the noncondensibles. The noncondensed balance of the heat transfer fluid and the noncondensibles passed to the drywell from the containment condenser are mixed with the heat transfer fluid and the noncondensibles from the RPV for passage into the containment condenser. A water pool is provided in heat transfer relationship with the containment condenser and is thermally communicable in an emergency situation with an environment outside of the drywell and the wetwell for conducting heat transferred from the containment condenser away from the wetwell and the drywell. 5 figs.

  12. Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis

    SciTech Connect (OSTI)

    Pourgholami, Mohammad H.; Khachigian, Levon M.; Fahmy, Roger G.; Badar, Samina; Wang, Lisa; Chu, Stephanie Wai Ling; Morris, David Lawson

    2010-07-09

    The angiogenic process begins with the cell proliferation and migration into the primary vascular network, and leads to vascularization of previously avascular tissues and organs as well to growth and remodeling of the initially homogeneous capillary plexus to form a new microcirculation. Additionally, an increase in microvascular permeability is a crucial step in angiogenesis. Vascular endothelial growth factor (VEGF) plays a central role in angiogenesis. We have previously reported that albendazole suppresses VEGF levels and inhibits malignant ascites formation, suggesting a possible effect on angiogenesis. This study was therefore designed to investigate the antiangiogenic effect of albendazole in non-cancerous models of angiogenesis. In vitro, treatment of human umbilical vein endothelial cells (HUVECs) with albendazole led to inhibition of tube formation, migration, permeability and down-regulation of the VEGF type 2 receptor (VEGFR-2). In vivo albendazole profoundly inhibited hyperoxia-induced retinal angiogenesis in mice. These results provide new insights into the antiangiogenic effects of albendazole.

  13. Suppression of the Critical Temperature of Superconducting NdFeAs(OF) Single Crystals by Kondo-Like Defect Sites Induced by {alpha}-Particle Irradiation

    SciTech Connect (OSTI)

    Tarantini, C.; Gurevich, A.; Larbalestier, D. C.; Putti, M.; Shen, Y.; Singh, R. K.; Rowell, J. M.; Newman, N.; Cheng Peng; Jia Ying; Wen Haihu

    2010-02-26

    We report the effect of {alpha}-particle irradiation on the reduction of the critical temperature T{sub c} of a NdFeAs(OF) single crystal. Our data indicate that irradiation defects cause both nonmagnetic and magnetic scattering, resulting in the Kondo-like excess resistance {Delta}{rho}(T)propor tolnT over 2 decades in temperatures above T{sub c}. The critical density of magnetic irradiation defects which suppresses T{sub c} is found to be much higher than those for cuprates and multiband BCS superconductors. We suggest that such anomalously weak pair breaking by irradiation defects indicates that magnetic scattering in pnictides is coupled with pairing interactions mediated by spin fluctuations.

  14. The suppression effect of a periodic surface with semicircular grooves on the high power microwave long pill-box window multipactor phenomenon

    SciTech Connect (OSTI)

    Zhang, Xue Wang, Yong; Fan, Junjie; Zhong, Yong; Zhang, Rui

    2014-09-15

    To improve the transmitting power in an S-band klystron, a long pill-box window that has a disk with grooves with a semicircular cross section is theoretically investigated and simulated. A Monte-Carlo algorithm is used to track the secondary electron trajectories and analyze the multipactor scenario in the long pill-box window and on the grooved surface. Extending the height of the long-box window can decrease the normal electric field on the surface of the window disk, but the single surface multipactor still exists. It is confirmed that the window disk with periodic semicircular grooves can explicitly suppress the multipactor and predominantly depresses the local field enhancement and the bottom continuous multipactor. The difference between semicircular and sharp boundary grooves is clarified numerically and analytically.

  15. Hydrogen-doping stabilized metallic VO{sub 2} (R) thin films and their application to suppress Fabry-Perot resonances in the terahertz regime

    SciTech Connect (OSTI)

    Zhao, Yong; Pan, Xuan; Bernussi, Ayrton A.; Fan, Zhaoyang, E-mail: Zhaoyang.Fan@ttu.edu [Department of Electrical and Computer Engineering and Nano Tech Center, Lubbock, Texas 79409 (United States); Karaoglan-Bebek, Gulten [Department of Physics and Nano Tech Center, Lubbock, Texas 79409 (United States); Holtz, Mark [Department of Physics and MSEC, Texas State University, San Marcos, Texas 78666 (United States)

    2014-06-16

    We demonstrate that catalyst-assisted hydrogen spillover doping of VO{sub 2} thin films significantly alters the metal-insulator transition characteristics and stabilizes the metallic rutile phase at room temperature. With hydrogen inserted into the VO{sub 2} lattice, high resolution X-ray diffraction reveals expansion of the V-V chain separation when compared to the VO{sub 2}(R) phase. The donated free electrons, possibly from O-H bond formation, stabilize the VO{sub 2}(R) to low temperatures. By controlling the amount of dopants to obtain mixed insulating and metallic phases, VO{sub 2} resistivity can be continuously tuned until a critical condition is achieved that suppresses Fabry-Perot resonances. Our results demonstrate that hydrogen spillover is an effective technique to tune the electrical and optical properties of VO{sub 2} thin films.

  16. Strange quark suppression and strange hadron production in pp collisions at energies available at the BNL Relativistic Heavy Ion Collider and the CERN Large Hadron Collider

    SciTech Connect (OSTI)

    Long Haiyan; Feng Shengqin; Zhou Daimei; Yan Yuliang; Ma Hailiang; Sa Benhao

    2011-09-15

    The parton and hadron cascade model PACIAE based on PYTHIA is utilized to systematically investigate strange particle production in pp collisions at energies available at the BNL Relativistic Heavy Ion Collider (RHIC) and the CERN Large Hadron Collider (LHC). Globally speaking, the PACIAE results of the strange particle rapidity density at midrapidity and the transverse momentum distribution are better than those of PYTHIA (default) in comparison with STAR and ALICE experimental data. This may represent the importance of the parton and hadron rescatterings, as well as the reduction mechanism of strange quark suppression, added in the PACIAE model. The K/{pi} ratios as a function of reaction energy in pp collisions from CERN Super Proton Synchrotron (SPS) to LHC energies are also analyzed in this paper.

  17. 5f delocalization-induced suppression of quadrupolar order in U(Pd1-xPtx)₃

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Walker, H. C.; Le, M. D.; McEwen, K. A.; Bleckmann, M.; Süllow, S.; Mazzoli, C.; Wilkins, S. B.; Fort, D.

    2011-12-27

    We present bulk magnetic and transport measurements and x-ray resonant scattering measurements on U(Pd1-xPtx)₃ for x=0.005 and 0.01, which demonstrate the high sensitivity of the quadrupolar order in the canonical antiferroquadrupolar ordered system UPd₃ to doping with platinum. Bulk measurements for x=0.005 reveal behavior similar to that seen in UPd₃, albeit at a lower temperature, and x-ray resonant scattering provides evidence of quadrupolar order described by the Qxy order parameter. In contrast, bulk measurements reveal only an indistinct transition in x=0.01, consistent with the observation of short-range quadrupolar order in our x-ray resonant scattering results.

  18. miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2

    SciTech Connect (OSTI)

    Li, Xuesong; Gong, Xuhai; Chen, Jing; Zhang, Jinghui; Sun, Jiahang; Guo, Mian

    2015-05-08

    Glioblastoma development is often associated with alteration in the activity and expression of cell cycle regulators, such as cyclin-dependent kinases (CKDs) and cyclins, resulting in aberrant cell proliferation. Recent studies have highlighted the pivotal roles of miRNAs in controlling the development and growth of glioblastoma. Here, we provide evidence for a function of miR-340 in the inhibition of glioblastoma cell proliferation. We found that miR-340 is downregulated in human glioblastoma tissue samples and several established glioblastoma cell lines. Proliferation and neurosphere formation assays revealed that miR-340 plays an oncosuppressive role in glioblastoma, and that its ectopic expression causes significant defect in glioblastoma cell growth. Further, using bioinformatics, luciferase assay and western blot, we found that miR-340 specifically targets the 3′UTRs of CDK6, cyclin-D1 and cyclin-D2, leading to the arrest of glioblastoma cells in the G0/G1 cell cycle phase. Confirming these results, we found that re-introducing CDK6, cyclin-D1 or cyclin-D2 expression partially, but significantly, rescues cells from the suppression of cell proliferation and cell cycle arrest mediated by miR-340. Collectively, our results demonstrate that miR-340 plays a tumor-suppressive role in glioblastoma and may be useful as a diagnostic biomarker and/or a therapeutic avenue for glioblastoma. - Highlights: • miR-340 is downregulated in glioblastoma samples and cell lines. • miR-340 inhibits glioblastoma cell proliferation. • miR-340 directly targets CDK6, cyclin-D1, and cyclin-D2. • miR-340 regulates glioblastoma cell proliferation via CDK6, cyclin-D1 and cyclin-D2.

  19. Prospective Study Evaluating Postoperative Radiotherapy Plus 2-Year Androgen Suppression for Post-Radical Prostatectomy Patients With Pathologic T3 Disease and/or Positive Surgical Margins

    SciTech Connect (OSTI)

    Choo, Richard [Department of Radiation Oncology, Mayo Clinic, Rochester, MN (United States)], E-mail: choo.c@mayo.edu; Danjoux, Cyril; Gardner, Sandra; Morton, Gerard; Szumacher, Ewa; Loblaw, D. Andrew; Cheung, Patrick [Department of Radiation Oncology, Odette Cancer Centre, University of Toronto, Toronto, ON (Canada); Pearse, Maria [Department of Radiation Oncology, Auckland Hospital, Auckland (New Zealand)

    2009-10-01

    Purpose: To determine the efficacy of a combined approach of postoperative radiotherapy (RT) plus 2-year androgen suppression (AS) for patients with pathologic T3 disease (pT3) and/or positive surgical margins (PSM) after radical prostatectomy (RP). Methods and Materials: A total of 78 patients with pT3 and/or PSM after RP were treated with RT plus 2-year AS, as per a pilot, prospective study. Androgen suppression started within 1 month after the completion of RT and consisted of nilutamide for 4 weeks and buserelin acetate depot subcutaneously every 2 months for 2 years. Relapse-free rate, including freedom from prostate-specific antigen (PSA) relapse, was estimated using the Kaplan-Meier method. A Cox regression analysis was performed to evaluate prognostic factors for relapse. Prostate-specific antigen relapse was defined as a PSA rise above 0.2 ng/mL, with two consecutive increases over a minimum of 3 months. Results: The median age was 61 years at the time of RP. The median interval between RP and postoperative RT was 4.2 months. Forty-nine patients had undetectable PSA (<0.2 ng/mL), and 29 had persistently detectable postoperative PSA at the time of the protocol treatment. Median follow-up from RT was 6.4 years. Relapse-free rates at 5 and 7 years were 94.4% and 86.3%, respectively. Survival rates were 96% at 5 years and 93.1% at 7 years. On Cox regression analysis, persistently detectable postoperative PSA and pT3b-T4 were significant predictors for relapse. Conclusion: The combined treatment of postoperative RT plus 2-year AS yielded encouraging results for patients with pT3 and/or PSM and warrants a confirmatory study.

  20. Systems Engineering

    Broader source: Energy.gov [DOE]

    Project objectives: to create an interactive, physics based, systems analysis tool for geothermal energy development that will: Identify points of attack to maximize efforts and investment dollars; Identify the parameter space where geothermal energy production is physically and economically viable; Provide a platform for public education and interaction.

  1. Corrigendum to Suppression of ? production in d+Au and Au+Au collisions at ? SNN = 200 GeV" [Phys. Lett. B 735 (2014) 127-137

    SciTech Connect (OSTI)

    Adamczyk, L.

    2015-04-01

    We report measurements of ? meson production in p + p, d + Au, and Au+Au collisions using the STAR detector at RHIC. We compare the ? yield to the measured cross section in p + p collisions in order to quantify any modifications of the yield in cold nuclear matter using d + Au data and in hot nuclear matter using Au+Au data separated into three centrality classes. Our p + p measurement is based on three times the statistics of our previous result. We obtain a nuclear modification factor for Upsilon (1S + 2S + 3S) in the rapidity range |y| < 1 in d + Au collisions of RdAu = 0.79 0.24(stat.) 0.03(syst.) 0.10(p + p syst.). A comparison with models including shadowing and initial state parton energy loss indicates the presence of additional cold-nuclear matter suppression. Similarly, in the top 10% most-central Au + Au collisions, we measure a nuclear modification factor of R AA = 0.49 0.1(stat.) 0.02(syst.) 0.06(p + p syst.), which is a larger suppression factor than that seen in cold nuclear matter. Our results are consistent with complete suppression of excited-state Upsilon mesons in Au + Au collisions. The additional suppression in Au + Au is consistent with the level expected in model calculations that include the presence of a hot, deconfined QuarkGluon Plasma. However, understanding the suppression seen in d + Au is still needed before any definitive statements about the nature of the suppression in Au + Au can be made.

  2. Corrigendum to “Suppression of Υ production in d+Au and Au+Au collisions at √ SNN = 200 GeV" [Phys. Lett. B 735 (2014) 127-137

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Adamczyk, L.

    2015-04-01

    We report measurements of Υ meson production in p + p, d + Au, and Au+Au collisions using the STAR detector at RHIC. We compare the Υ yield to the measured cross section in p + p collisions in order to quantify any modifications of the yield in cold nuclear matter using d + Au data and in hot nuclear matter using Au+Au data separated into three centrality classes. Our p + p measurement is based on three times the statistics of our previous result. We obtain a nuclear modification factor for Upsilon (1S + 2S + 3S) in themore »rapidity range |y| dAu = 0.79 ± 0.24(stat.) ± 0.03(syst.) ± 0.10(p + p syst.). A comparison with models including shadowing and initial state parton energy loss indicates the presence of additional cold-nuclear matter suppression. Similarly, in the top 10% most-central Au + Au collisions, we measure a nuclear modification factor of R AA = 0.49 ±0.1(stat.) ±0.02(syst.) ±0.06(p + p syst.), which is a larger suppression factor than that seen in cold nuclear matter. Our results are consistent with complete suppression of excited-state Upsilon mesons in Au + Au collisions. The additional suppression in Au + Au is consistent with the level expected in model calculations that include the presence of a hot, deconfined Quark–Gluon Plasma. However, understanding the suppression seen in d + Au is still needed before any definitive statements about the nature of the suppression in Au + Au can be made.« less

  3. Corrigendum to “Suppression of Υ production in d+Au and Au+Au collisions at √ SNN = 200 GeV" [Phys. Lett. B 735 (2014) 127-137

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Adamczyk, L.

    2015-04-01

    We report measurements of Υ meson production in p + p, d + Au, and Au+Au collisions using the STAR detector at RHIC. We compare the Υ yield to the measured cross section in p + p collisions in order to quantify any modifications of the yield in cold nuclear matter using d + Au data and in hot nuclear matter using Au+Au data separated into three centrality classes. Our p + p measurement is based on three times the statistics of our previous result. We obtain a nuclear modification factor for Upsilon (1S + 2S + 3S) in themore » rapidity range |y| < 1 in d + Au collisions of RdAu = 0.79 ± 0.24(stat.) ± 0.03(syst.) ± 0.10(p + p syst.). A comparison with models including shadowing and initial state parton energy loss indicates the presence of additional cold-nuclear matter suppression. Similarly, in the top 10% most-central Au + Au collisions, we measure a nuclear modification factor of R AA = 0.49 ±0.1(stat.) ±0.02(syst.) ±0.06(p + p syst.), which is a larger suppression factor than that seen in cold nuclear matter. Our results are consistent with complete suppression of excited-state Upsilon mesons in Au + Au collisions. The additional suppression in Au + Au is consistent with the level expected in model calculations that include the presence of a hot, deconfined Quark–Gluon Plasma. However, understanding the suppression seen in d + Au is still needed before any definitive statements about the nature of the suppression in Au + Au can be made.« less

  4. Burner systems

    DOE Patents [OSTI]

    Doherty, Brian J.

    1984-07-10

    A burner system particularly useful for downhole deployment includes a tubular combustion chamber unit housed within a tubular coolant jacket assembly. The combustion chamber unit includes a monolithic tube of refractory material whose inner surface defines the combustion zone. A metal reinforcing sleeve surrounds and extends the length of the refractory tube. The inner surface of the coolant jacket assembly and outer surface of the combustion chamber unit are dimensioned so that those surfaces are close to one another in standby condition so that the combustion chamber unit has limited freedom to expand with that expansion being stabilized by the coolant jacket assembly so that compression forces in the refractory tube do not exceed about one-half the safe compressive stress of the material; and the materials of the combustion chamber unit are selected to establish thermal gradient parameters across the combustion chamber unit to maintain the refractory tube in compression during combustion system start up and cool down sequences.

  5. Directives System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1998-01-30

    The Department of Energy (DOE) Directives System is the means by which DOE policies, requirements, and responsibilities are developed and communicated throughout the Department. Directives are used to inform, direct, and guide employees in the performance of their jobs, and to enable employees to work effectively within the Department and with agencies, contractors, and the public. Cancels: DOE O 251.1, DOE M 251.1-1

  6. Monitoring Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Fuel Cycle Defense Waste Management Programs Advanced Nuclear Energy

  7. WEC system

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    system - Sandia Energy Energy Search Icon Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable Energy Future Stationary Power Energy Conversion Efficiency Solar Energy Wind Energy Water Power Supercritical CO2 Geothermal Natural Gas Safety, Security & Resilience of the Energy Infrastructure Energy Storage Nuclear Power & Engineering Grid Modernization Battery Testing Nuclear Fuel Cycle Defense Waste Management Programs Advanced Nuclear Energy

  8. Security system

    DOE Patents [OSTI]

    Baumann, Mark J.; Kuca, Michal; Aragon, Mona L.

    2016-02-02

    A security system includes a structure having a structural surface. The structure is sized to contain an asset therein and configured to provide a forceful breaching delay. The structure has an opening formed therein to permit predetermined access to the asset contained within the structure. The structure includes intrusion detection features within or associated with the structure that are activated in response to at least a partial breach of the structure.

  9. Gasification system

    DOE Patents [OSTI]

    Haldipur, Gaurang B.; Anderson, Richard G.; Cherish, Peter

    1983-01-01

    A method and system for injecting coal and process fluids into a fluidized bed gasification reactor. Three concentric tubes extend vertically upward into the fluidized bed. Coal particulates in a transport gas are injected through an inner tube, and an oxygen rich mixture of oxygen and steam are injected through an inner annulus about the inner tube. A gaseous medium relatively lean in oxygen content, such as steam, is injected through an annulus surrounding the inner annulus.

  10. Gasification system

    DOE Patents [OSTI]

    Haldipur, Gaurang B.; Anderson, Richard G.; Cherish, Peter

    1985-01-01

    A method and system for injecting coal and process fluids into a fluidized bed gasification reactor. Three concentric tubes extend vertically upward into the fluidized bed. Coal particulates in a transport gas are injected through an inner tube, and an oxygen rich mixture of oxygen and steam are injected through an inner annulus about the inner tube. A gaseous medium relatively lean in oxygen content, such as steam, is injected through an annulus surrounding the inner annulus.

  11. CONTROL SYSTEM

    DOE Patents [OSTI]

    Shannon, R.H.; Williamson, H.E.

    1962-10-30

    A boiling water type nuclear reactor power system having improved means of control is described. These means include provisions for either heating the coolant-moderator prior to entry into the reactor or shunting the coolantmoderator around the heating means in response to the demand from the heat engine. These provisions are in addition to means for withdrawing the control rods from the reactor. (AEC)

  12. Computer System,

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    System, Cluster, and Networking Summer Institute New Mexico Consortium and Los Alamos National Laboratory HOW TO APPLY Applications will be accepted JANUARY 5 - FEBRUARY 13, 2016 Computing and Information Technology undegraduate students are encouraged to apply. Must be a U.S. citizen. * Submit a current resume; * Offcial University Transcript (with spring courses posted and/or a copy of spring 2016 schedule) 3.0 GPA minimum; * One Letter of Recommendation from a Faculty Member; and * Letter of

  13. Braking system

    DOE Patents [OSTI]

    Norgren, D.U.

    1982-09-23

    A balanced braking system comprising a plurality of braking assemblies located about a member to be braked. Each of the braking assemblies consists of a spring biased piston of a first material fitted into a body of a different material which has a greater contraction upon cooling than the piston material. The piston is provided with a recessed head portion over which is positioned a diaphragm and forming a space therebetween to which is connected a pressurized fluid supply. The diaphragm is controlled by the fluid in the space to contact or withdraw from the member to be braked. A cooling means causes the body within which the piston is fitted to contract more than the piston, producing a tight shrink fit therebetween. The braking system is particularly applicable for selectively braking an arbor of an electron microscope which immobilizes, for example, a vertically adjustable low temperature specimen holder during observation. The system provides balanced braking forces which can be easily removed and re-established with minimal disturbance to arbor location.

  14. NREL: Energy Systems Integration - Systems Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    High-level system integration New distribution scenarios such as household DC systems and residential-scale generation and storage integrated with home energy management systems. ...

  15. Hydraulic model analysis of water distribution system, Rockwell International, Rocky Flats, Colorado

    SciTech Connect (OSTI)

    Perstein, J.; Castellano, J.A.

    1989-01-20

    Rockwell International requested an analysis of the existing plant site water supply distribution system at Rocky Flats, Colorado, to determine its adequacy. On September 26--29, 1988, Hughes Associates, Inc., Fire Protection Engineers, accompanied by Rocky Flats Fire Department engineers and suppression personnel, conducted water flow tests at the Rocky Flats plant site. Thirty-seven flows from various points throughout the plant site were taken on the existing domestic supply/fire main installation to assure comprehensive and thorough representation of the Rocky Flats water distribution system capability. The analysis was completed in four phases which are described, together with a summary of general conclusions and recommendations.

  16. The veto system of the DarkSide-50 experiment (Journal Article) | SciTech

    Office of Scientific and Technical Information (OSTI)

    Connect The veto system of the DarkSide-50 experiment Citation Details In-Document Search Title: The veto system of the DarkSide-50 experiment Nuclear recoil events produced by neutron scatters form one of the most important classes of background in WIMP direct detection experiments, as they may produce nuclear recoils that look exactly like WIMP interactions. In DarkSide-50, we both actively suppress and measure the rate of neutron-induced background events using our neutron veto, composed

  17. Real-time system for imaging and object detection with a multistatic GPR array

    DOE Patents [OSTI]

    Paglieroni, David W; Beer, N Reginald; Bond, Steven W; Top, Philip L; Chambers, David H; Mast, Jeffrey E; Donetti, John G; Mason, Blake C; Jones, Steven M

    2014-10-07

    A method and system for detecting the presence of subsurface objects within a medium is provided. In some embodiments, the imaging and detection system operates in a multistatic mode to collect radar return signals generated by an array of transceiver antenna pairs that is positioned across the surface and that travels down the surface. The imaging and detection system pre-processes the return signal to suppress certain undesirable effects. The imaging and detection system then generates synthetic aperture radar images from real aperture radar images generated from the pre-processed return signal. The imaging and detection system then post-processes the synthetic aperture radar images to improve detection of subsurface objects. The imaging and detection system identifies peaks in the energy levels of the post-processed image frame, which indicates the presence of a subsurface object.

  18. Refrigeration system

    SciTech Connect (OSTI)

    Pagani, R.F.; Clarke, K.J.; Avon, E.J.

    1986-11-11

    This patent describes a chamber including an expandable refrigerant system associated therewith. The system comprises reservoir containing an expandable refrigerant coolant and lead piping connecting the reservoir to conduits carrying the coolant therein. The chamber comprises top, bottom and side walls, accordingly defining an interior and an exterior to the chamber, one of the walls comprises a door affording access into the chamber, each of the walls being insulated with insulating material. At least one of the walls comprises a first layer of the insulating material extending thereover adjacent the exterior and a second layer of the insulating material extending thereover adjacent the interior. The reservoir, lead piping and conduits are disposed intermediate the first and second layers of insulating material thereby isolating them from both the interior and exterior. Heat transferring through the at least one wall is substantially absorbed by the coolant and the insulating material cooled by the coolant, before it is able to penetrate through the at least one wall, permitting a product placed in the chamber to effectively maintain or substantially maintain a selected even temperature.

  19. NREL: Energy Systems Integration Facility - Systems Integration

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems Integration Systems integration considers the relationships among electricity, thermal, and fuel systems and data and information networks to ensure optimal interoperability across the energy spectrum. The Energy Systems Integration Facility's suite of systems integration laboratories provides advanced capabilities for research, development, and demonstration of key components of future energy systems. Photo of a man and a power quality meter system in a laboratory. The Energy Systems

  20. Intelligent Transportation Systems Deployment Analysis System...

    Open Energy Info (EERE)

    Transportation Systems Deployment Analysis System AgencyCompany Organization: Cambridge Systematics Sector: Energy Focus Area: Transportation Resource Type: Software...

  1. Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach

    SciTech Connect (OSTI)

    Abhilash, P.A.; Harikrishnan, R.; Indira, M.

    2014-01-15

    Alcohol consumption increases the small intestinal bacterial overgrowth (SIBO) and intestinal permeability of endotoxin. The endotoxin mediated inflammatory signaling plays a major role in alcoholic liver fibrosis. We evaluated the effect of ascorbic acid (AA), silymarin and alcohol abstention on the alcohol induced endotoxemia and NF-κB activation cascade pathway in guinea pigs (Cavia porcellus). Guinea pigs were administered ethanol at a daily dose of 4 g/kg b.wt for 90 days. After 90 days, ethanol administration was stopped. The ethanol treated animals were divided into abstention, silymarin (250 mg/kg b.wt) and AA (250 mg/kg b.wt) supplemented groups and maintained for 30 days. The SIBO, intestinal permeability and endotoxin were significantly increased in the ethanol group. The mRNA expressions of intestinal proteins claudin, occludin and zona occludens-1 were significantly decreased in ethanol group. The mRNA levels of inflammatory receptors, activity of IKKβ and the protein expressions of phospho-IκBα, NF-κB, TNF-α, TGF-β{sub 1} and IL-6 were also altered in ethanol group. The expressions of fibrosis markers α-SMA, α{sub 1} (I) collagen and sirius red staining in the liver revealed the induction of fibrosis. But the supplementation of AA could induce greater reduction of ethanol induced SIBO, intestinal barrier defects, NF-κB activation and liver fibrosis than silymarin. The possible mechanism may be the inhibitory effect of AA on SIBO, intestinal barrier defect and IKKβ, which decreased the activation of NF-κB and synthesis of cytokines. This might have led to suppression of HSCs activation and liver fibrosis. - Highlights: • Alcohol increases intestinal bacterial overgrowth and permeability of endotoxin. • Endotoxin mediated inflammation plays a major role in alcoholic liver fibrosis. • Ascorbic acid reduces endotoxemia, NF-κB activation and proinflammatory cytokines. • AA's action is by inhibition of SIBO, IKKβ and alteration of intestinal permeability. • This might have led to suppression of HSCs activation and liver fibrosis.

  2. Suppression of activation energy and superconductivity by the addition of Al{sub 2}O{sub 3} nanoparticles in CuTl-1223 matrix

    SciTech Connect (OSTI)

    Jabbar, Abdul; Qasim, Irfan; Mumtaz, M.; Zubair, M.; Nadeem, K.; Khurram, A. A.

    2014-05-28

    Low anisotropic (Cu{sub 0.5}Tl{sub 0.5})Ba{sub 2}Ca{sub 2}Cu{sub 3}O{sub 10??} (CuTl-1223) high T{sub c} superconducting matrix was synthesized by solid-state reaction and Al{sub 2}O{sub 3} nanoparticles were prepared separately by co-precipitation method. Al{sub 2}O{sub 3} nanoparticles were added with different concentrations during the final sintering cycle of CuTl-1223 superconducting matrix to get the required (Al{sub 2}O{sub 3}){sub y}/CuTl-1223, y?=?0.0, 0.5, 0.7, 1.0, and 1.5?wt.?%, composites. The samples were characterized by X-ray diffraction (XRD), scanning electron microscopy, energy dispersive X-ray, and dc-resistivity (?) measurements. The activation energy and superconductivity were suppressed with increasing concentration of Al{sub 2}O{sub 3} nanoparticles in (CuTl-1223) matrix. The XRD analysis showed that the addition of Al{sub 2}O{sub 3} nanoparticles did not affect the crystal structure of the parent CuTl-1223 superconducting phase. The suppression of activation energy and superconducting properties is most probably due to weak flux pinning in the samples. The possible reason of weak flux pinning is reduction of weak links and enhanced inter-grain coupling due to the presence of Al{sub 2}O{sub 3} nanoparticles at the grain boundaries. The presence of Al{sub 2}O{sub 3} nanoparticles at the grain boundaries possibly reduced the number of flux pinning centers, which were present in the form of weak links in the pure CuTl-1223 superconducting matrix. The increase in the values of inter-grain coupling (?) deduced from the fluctuation induced conductivity analysis with the increased concentration of Al{sub 2}O{sub 3} nanoparticles is a theoretical evidence of improved inter-grain coupling.

  3. Power Systems Engineering

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    systems; steam, water, fuel, and environmental monitoring systems; alternative energy systems; reliability, availability, and maintainability assessments; and associated...

  4. Interferometric at-wavelength flare characterization of EUV optical systems

    DOE Patents [OSTI]

    Naulleau, Patrick P.; Goldberg, Kenneth Alan

    2001-01-01

    The extreme ultraviolet (EUV) phase-shifting point diffraction interferometer (PS/PDI) provides the high-accuracy wavefront characterization critical to the development of EUV lithography systems. Enhancing the implementation of the PS/PDI can significantly extend its spatial-frequency measurement bandwidth. The enhanced PS/PDI is capable of simultaneously characterizing both wavefront and flare. The enhanced technique employs a hybrid spatial/temporal-domain point diffraction interferometer (referred to as the dual-domain PS/PDI) that is capable of suppressing the scattered-reference-light noise that hinders the conventional PS/PDI. Using the dual-domain technique in combination with a flare-measurement-optimized mask and an iterative calculation process for removing flare contribution caused by higher order grating diffraction terms, the enhanced PS/PDI can be used to simultaneously measure both figure and flare in optical systems.

  5. Systems and methods for dismantling a nuclear reactor

    DOE Patents [OSTI]

    Heim, Robert R; Adams, Scott Ryan; Cole, Matthew Denver; Kirby, William E; Linnebur, Paul Damon

    2014-10-28

    Systems and methods for dismantling a nuclear reactor are described. In one aspect the system includes a remotely controlled heavy manipulator ("manipulator") operatively coupled to a support structure, and a control station in a non-contaminated portion of a workspace. The support structure provides the manipulator with top down access into a bioshield of a nuclear reactor. At least one computing device in the control station provides remote control to perform operations including: (a) dismantling, using the manipulator, a graphite moderator, concrete walls, and a ceiling of the bioshield, the manipulator being provided with automated access to all internal portions of the bioshield; (b) loading, using the manipulator, contaminated graphite blocks from the graphite core and other components from the bioshield into one or more waste containers; and (c) dispersing, using the manipulator, dust suppression and contamination fixing spray to contaminated matter.

  6. Transfer system

    DOE Patents [OSTI]

    Kurosawa, Kanji; Koga, Bunichiro; Ito, Hideki; Kiriyama, Shigeru; Higuchi, Shizuo

    2003-05-20

    A transport system includes a traveling rail (1) which constitutes a transport route and a transport body (3) which is capable of traveling on the traveling rail in the longitudinal direction of the traveling rail. Flexible drive tubes (5) are arranged on the traveling rail in the longitudinal direction of the traveling rail. The transport body includes a traveling wheel (4) which is capable of rolling on the traveling rail and drive wheels (2) which are capable of rolling on the drive tubes upon receiving the rotational drive power generated by pressure of a pressure medium supplied to the drive tubes while depressing the drive tubes. The traveling rail includes a plurality of transport sections and the transport body is capable of receiving a rotational drive force from the drive tubes at every transport sections. If necessary, a transport route changeover switch which changes over the transport route can be provided between the transport sections.

  7. Suppression of the spin pumping in Pd/Ni{sub 81}Fe{sub 19} bilayers with nano-oxide layer

    SciTech Connect (OSTI)

    Kim, Duck-Ho; Kim, Hong-Hyoun; You, Chun-Yeol

    2011-08-15

    We demonstrate that the spin pumping effect can be effectively suppressed with a nano-oxide layer. Spin pumping effect manifests itself by an enhancement of the Gilbert damping parameter in normal metal/ferromagnetic hetero-structures, while many spintronics devices prefer smaller damping parameter. Since the spin pumping effect is directly related with the spin dependent interface conductance, we can modify the spin pumping by altering the interface conductance with the nano-oxide layer. We prepared series of Pd/Ni{sub 81}Fe{sub 19} bilayers with different pausing time between Pd and Ni{sub 81}Fe{sub 19} depositions in order to control the interface conductance. The Gilbert damping parameters are determined from the line-width measurements in the ferromagnetic resonance spectra for each pausing time sample. They are 0.0490, 0.0296, 0.0278, and 0.0251 for 0, 6, 30, and 60 s pausing time, respectively. We find that the damping parameter of Pd/Ni{sub 81}Fe{sub 19} is almost recovered to one of the Cu/Ni{sub 81}Fe{sub 19} bilayer with 60 s pausing time, while the static magnetic properties are not noticeably changed.

  8. miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma

    SciTech Connect (OSTI)

    Chen, Suling; Li, Fang; Chai, Haiyun; Tao, Xin; Wang, Haili; Ji, Aifang

    2015-08-21

    MicroRNAs (miRNAs) play a key role in carcinogenesis and tumor progression in hepatocellular carcinoma (HCC). In the present study, we demonstrated that miR-502 significantly inhibits HCC cell proliferation in vitro and tumor growth in vivo. G1/S cell cycle arrest and apoptosis of HCC cells were induced by miR-502. Phosphoinositide 3-kinase catalytic subunit gamma (PIK3CG) was identified as a direct downstream target of miR-502 in HCC cells. Notably, overexpression of PIK3CG reversed the inhibitory effects of miR-502 in HCC cells. Our findings suggest that miR-502 functions as a tumor suppressor in HCC via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type. - Highlights: • miR-502 suppresses HCC cell proliferation in vitro and tumorigenicity in vivo. • miR-502 regulates cell cycle and apoptosis in HCC cells. • PIK3CG is a direct target of miR-502. • miR-502 and PIK3CG expression patterns are inversely correlated in HCC tissues.

  9. Suppression of unimolecular decay of laser desorbed peptide and protein ions by entrainment in rarefied supersonic gas jets under weak electric fields

    SciTech Connect (OSTI)

    Hieke, Andreas

    2014-01-21

    Unimolecular decay of sample ions imposes a limit on the usable laser fluence in matrix-assisted laser desorption/ionization (MALDI) ion sources. Traditionally, some modest degree of collisional sample ion cooling has been achieved by connecting MALDI ion sources directly to gas-filled radio frequency (RF) multipoles. It was also discovered in the early 1990s that gas-filled RF multipoles exhibit increased ion transmission efficiency due to collisional ion focusing effects. This unexpected experimental finding was later supported by elementary Monte Carlo simulations. Both experiments and simulations assumed a resting background gas with typical pressures of the order of 1 Pa. However, considerable additional improvements can be achieved if laser desorbed sample ions are introduced immediately after desorption, still within the ion source, in an axisymmetric rarefied supersonic gas jet with peak pressure of the order of 100 Pa and flow velocities >300 m/s, and under weak electric fields. We describe here the design principle and report performance data of an ion source coined “MALDI-2,” which incorporates elements of both rarefied aerodynamics and particle optics. Such a design allows superb suppression of metastable fragmentation due to rapid collisional cooling in <10 μs and nearly perfect injection efficiency into the attached RF ion guide, as numerous experiments have confirmed.

  10. First Observation of the Cabibbo-suppressed Decays Xi+(c) ---> Sigma+ pi- pi+ and Xi+(c) ---> Sigma- pi+ pi+ and Measurement of their Branching Ratios

    SciTech Connect (OSTI)

    Vazquez-Jauregui, E.; Engelfried, J.; Akgun, U.; Alkhazov, Georgiy; Amaro-Reyes, J.; Atamantchouk, A.G.; Ayan, Ahmet Sedat; Balatz, M.Y.; Blanco-Covarrubias, A.; Bondar, N.F.; Cooper, Peter S.; /Fermilab /Michigan U., Flint

    2008-04-01

    The authors report the first observation of two Cabibbo-suppressed decay modes, {Xi}{sub c}{sup +} {yields} {Sigma}{sup +}{pi}{sup -}{pi}{sup +} and {Xi}{sub c}{sup +} {yields} {Sigma}{sup -} {pi}{sup +}{pi}{sup +}. They observe 56 {+-} 13 over a background of 21, and 23 {+-} 7 over a background of 12 events, respectively, for the signals. The data were accumulated using the SELEX spectrometer during the 1996-1997 fixed target run at Fermilab, chiefly from a 600 GeV/c {Sigma}{sup -} beam. The branching ratios of the decays relative to the Cabibbo-favored {Xi}{sub c}{sup +} {yields} {Xi}{sup -}{pi}{sup +}{pi}{sup +} are measured to be B({Xi}{sub c}{sup +} {yields} {Sigma}{sup +}{pi}{sup -}{pi}{sup +})/B({xi}{sub c}{sup +} {yields} {Xi}{sup -} {pi}{sup +}{pi}{sup +}) = 0.50 {+-} 0.20, and B({Xi}{sub c}{sup +} {yields} {Sigma}{sup -}{pi}{sup +}{pi}{sup +})/B({Xi}{sub c}{sup +} {yields} {Xi}{sup -}{pi}{sup +}{pi}{sup +}) = 0.23 {+-} 0.11, respectively. They also report branching ratios for the same decay modes of the {Lambda}{sub c}{sup +} relative to {Lambda}{sub c}{sup +} {yields} pK{sup -}{pi}{sup +}.

  11. Influence of dense quantum plasmas on fine-structure splitting of Lyman doublets of hydrogenic systems

    SciTech Connect (OSTI)

    De, Madhab Ray, Debasis

    2015-05-15

    Relativistic calculations are performed to study the effects of oscillatory quantum plasma screening on the fine-structure splitting between the components of Lyman-? and ? line doublets of atomic hydrogen and hydrgen-like argon ion within dense quantum plasmas, where the effective two-body (electronnucleus) interaction is modeled by the ShuklaEliasson oscillatory exponential cosine screened-Coulomb potential. The numerical solutions of the radial Dirac equation for the quantum plasma-embedded atomic systems reveal that the oscillatory quantum screening effect suppresses the doublet (energy) splitting substantially and the suppression becomes more prominent at large quantum wave number k{sub q}. In the absence of the oscillatory cosine screening term, much larger amount of suppression is noticed at larger values of k{sub q}, and the corresponding results represent the screening effect of an exponential screened-Coulomb two-body interaction. The Z{sup 4} scaling of the Lyman doublet splitting in low-Z hydrogen isoelectronic series of ions in free space is violated in dense quantum plasma environments. The relativistic data for the doublet splitting in the zero screening (k{sub q}?=?0) case are in very good agreement with the NIST reference data, with slight discrepancies (?0.2%) arising from the neglect of the quantum electrodynamic effects.

  12. Advanced coal-fueled industrial cogeneration gas turbine system particle removal system development

    SciTech Connect (OSTI)

    Stephenson, M.

    1994-03-01

    Solar Turbines developed a direct coal-fueled turbine system (DCFT) and tested each component in subscale facilities and the combustion system was tested at full-scale. The combustion system was comprised of a two-stage slagging combustor with an impact separator between the two combustors. Greater than 90 percent of the native ash in the coal was removed as liquid slag with this system. In the first combustor, coal water slurry mixture (CWM) was injected into a combustion chamber which was operated loan to suppress NO{sub x} formation. The slurry was introduced through four fuel injectors that created a toroidal vortex because of the combustor geometry and angle of orientation of the injectors. The liquid slag that was formed was directed downward toward an impaction plate made of a refractory material. Sixty to seventy percent of the coal-borne ash was collected in this fashion. An impact separator was used to remove additional slag that had escaped the primary combustor. The combined particulate collection efficiency from both combustors was above 95 percent. Unfortunately, a great deal of the original sulfur from the coal still remained in the gas stream and needed to be separated. To accomplish this, dolomite or hydrated lime were injected in the secondary combustor to react with the sulfur dioxide and form calcium sulfite and sulfates. This solution for the sulfur problem increased the dust concentrations to as much as 6000 ppmw. A downstream particulate control system was required, and one that could operate at 150 psia, 1850-1900{degrees}F and with low pressure drop. Solar designed and tested a particulate rejection system to remove essentially all particulate from the high temperature, high pressure gas stream. A thorough research and development program was aimed at identifying candidate technologies and testing them with Solar`s coal-fired system. This topical report summarizes these activities over a period beginning in 1987 and ending in 1992.

  13. Separation system

    DOE Patents [OSTI]

    Rubin, Leslie S.

    1986-01-01

    A separation system for dewatering radioactive waste materials includes a disposal container, drive structure for receiving the container, and means for releasably attaching the container to the drive structure. Separation structure disposed in the container adjacent the inner surface of the side wall structure retains solids while allowing passage of liquids. Inlet port structure in the container top wall is normally closed by first valve structure that is centrifugally actuated to open the inlet port and discharge port structure at the container periphery receives liquid that passes through the separation structure and is normally closed by second valve structure that is centrifugally actuated to open the discharge ports. The container also includes coupling structure for releasable engagement with the centrifugal drive structure. Centrifugal force produced when the container is driven in rotation by the drive structure opens the valve structures, and radioactive waste material introduced into the container through the open inlet port is dewatered, and the waste is compacted. The ports are automatically closed by the valves when the container drum is not subjected to centrifugal force such that containment effectiveness is enhanced and exposure of personnel to radioactive materials is minimized.

  14. Sway control method and system for rotary cranes

    DOE Patents [OSTI]

    Robinett, Rush D.; Parker, Gordon G.; Feddema, John T.; Dohrmann, Clark R.; Petterson, Ben J.

    1999-01-01

    Methods and apparatuses for reducing the oscillatory motion of rotary crane payloads during operator-commanded or computer-controlled maneuvers. An Input-shaping filter receives input signals from multiple operator input devices and converts them into output signals readable by the crane controller to dampen the payload tangential and radial sway associated with rotation of the jib. The input signals are characterized by a hub rotation trajectory .gamma.(t), which includes a jib angular acceleration .gamma., a trolley acceleration x, and a load-line length velocity L. The system state variables are characterized by a tangential rotation angle .theta.(t) and a radial rotation angle .phi.(t) of the load-line. The coupled equations of motion governing the filter are non-linear and configuration-dependent. In one embodiment, a filter is provided between the operator and the crane for filtering undesired frequencies from the angular .gamma. and trolley x velocities to suppress payload oscillation. In another embodiment, crane commands are computer generated and controlled to suppress vibration of the payload using a postulated asymmetrical shape for the acceleration profiles of the jib, which profiles are uniquely determined by a set of parameters (including the acceleration pulse amplitude and the duration and coast time between pulses), or a dynamic programming approach.

  15. Sway control method and system for rotary cranes

    DOE Patents [OSTI]

    Robinett, R.D.; Parker, G.G.; Feddema, J.T.; Dohrmann, C.R.; Petterson, B.J.

    1999-06-01

    Methods and apparatuses are disclosed for reducing the oscillatory motion of rotary crane payloads during operator-commanded or computer-controlled maneuvers. An Input-shaping filter receives input signals from multiple operator input devices and converts them into output signals readable by the crane controller to dampen the payload tangential and radial sway associated with rotation of the jib. The input signals are characterized by a hub rotation trajectory [gamma](t), which includes a jib angular acceleration [gamma], a trolley acceleration x, and a load-line length velocity L. The system state variables are characterized by a tangential rotation angle [theta](t) and a radial rotation angle [phi](t) of the load-line. The coupled equations of motion governing the filter are non-linear and configuration-dependent. In one embodiment, a filter is provided between the operator and the crane for filtering undesired frequencies from the angular [gamma] and trolley x velocities to suppress payload oscillation. In another embodiment, crane commands are computer generated and controlled to suppress vibration of the payload using a postulated asymmetrical shape for the acceleration profiles of the jib, which profiles are uniquely determined by a set of parameters (including the acceleration pulse amplitude and the duration and coast time between pulses), or a dynamic programming approach. 25 figs.

  16. Fire suppressing apparatus. [sodium fires

    DOE Patents [OSTI]

    Buttrey, K.E.

    1980-12-19

    Apparatus for smothering a liquid sodium fire comprises a pan, a perforated cover on the pan, and tubed depending from the cover and providing communication between the interior of the pan and the ambient atmosphere through the perforations in the cover. Liquid caught in the pan rises above the lower ends of the tubes and thus serves as a barrier which limits the amount of air entering the pan.

  17. Steam Systems, Retrofit Measure Packages, Hydronic Systems

    Energy Savers [EERE]

    Steam System Survey Guide Steam System Survey Guide This guide provides technical information for steam system operational personnel and plant energy managers on some of the major opportunities available to improve the energy efficiency and productivity of industrial steam systems. The guide covers five main areas of investigation: (1) profiling a steam system, (2) identifying steam properties for the steam system, (3) improving boiler operations, (4) improving resource utilization in the steam

  18. Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-κB and MAPK activation in macrophages and TPA-induced ear edema in mice

    SciTech Connect (OSTI)

    Kim, Young Nam; Kim, Dae Won; Jo, Hyo Sang; Shin, Min Jea; Ahn, Eun Hee; Ryu, Eun Ji; Yong, Ji In; Cha, Hyun Ju; Kim, Sang Jin; Yeo, Hyeon Ji; Youn, Jong Kyu; Hwang, Jae Hyeok; Jeong, Ji-Heon; Kim, Duk-Soo; Cho, Sung-Woo; Park, Jinseu; Eum, Won Sik; Choi, Soo Young

    2015-07-15

    Human carbonyl reductase 1 (CBR1) plays a crucial role in cell survival and protects against oxidative stress response. However, its anti-inflammatory effects are not yet clearly understood. In this study, we examined whether CBR1 protects against inflammatory responses in macrophages and mice using a Tat-CBR1 protein which is able to penetrate into cells. The results revealed that purified Tat-CBR1 protein efficiently transduced into Raw 264.7 cells and inhibited lipopolysaccharide (LPS)-induced cyclooxygenase-2 (COX-2), nitric oxide (NO) and prostaglandin E{sub 2} (PGE{sub 2}) expression levels. In addition, Tat-CBR1 protein leads to decreased pro-inflammatory cytokine expression through suppression of nuclear transcription factor-kappaB (NF-κB) and mitogen activated protein kinase (MAPK) activation. Furthermore, Tat-CBR1 protein inhibited inflammatory responses in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation when applied topically. These findings indicate that Tat-CBR1 protein has anti-inflammatory properties in vitro and in vivo through inhibition of NF-κB and MAPK activation, suggesting that Tat-CBR1 protein may have potential as a therapeutic agent against inflammatory diseases. - Highlights: • Transduced Tat-CBR1 reduces LPS-induced inflammatory mediators and cytokines. • Tat-CBR1 inhibits MAPK and NF-κB activation. • Tat-CBR1 ameliorates inflammation response in vitro and in vivo. • Tat-CBR1 may be useful as potential therapeutic agent for inflammation.

  19. Suppressing the Skin-Core Structure of Injection-Molded Isotactic Polypropylene via Combination of an in situ Microfibrillar Network and an Interfacial Compatibilizer

    SciTech Connect (OSTI)

    X Yi; C Chen; G Zhong; L Xu; J Tang; X Ji; B Hsiao; Z Li

    2011-12-31

    Injection-molded semicrystalline polymer parts generally exhibited a so-called skin-core structure basically as a result of the large gradients of temperature, shear rate, stress, and pressure fields created by the boundary conditions of injection molding. Suppression of the skin-core structure is a long-term practical challenge. In the current work, the skin-core structure of the conventional injection-molded isotactic polypropylene (iPP) was largely relieved by the cooperative effects of an in situ microfibrillar network and interfacial compatibilizer. The in situ poly(ethylene terephthalate) microfibrils of 1-8 {micro}m in diameter and large aspect ratios of above 40 tended to entangle with each other to generate a microfibrillar network in the iPP melt. During injection molding, the iPP molecules experienced confined flow in the microchannels or pores formed by the microfibrillar network, which could redistribute and homogenize the flow field of polymer melt. Addition of the compatibilizer, glycidyl methacrylate-grafted iPP, restrained the molecular orientation but facilitated preservation of oriented molecules due to the chemical bonds at the interface between PET microfibrils and iPP. The cooperative effects of in situ microfibrillar network and interfacial compatibilizer led to almost the same molecular orientation across the whole thickness of the injection-molded parts. Additionally, the content of {beta} crystals in different layers of injection-molded iPP parts depended on the combined effects of the molecular orientation, the amount of oriented crystals, and the crystallization time between 105 and 140 C. The presence of the interfacial compatibilizer facilitated formation of the {beta} crystals because of preservation of the oriented molecules.

  20. The plant limonoid 7-oxo-deacetoxygedunin inhibits RANKL-induced osteoclastogenesis by suppressing activation of the NF-{kappa}B and MAPK pathways

    SciTech Connect (OSTI)

    Wisutsitthiwong, Chonnaree; Buranaruk, Chayanit; Pudhom, Khanitha; Palaga, Tanapat

    2011-11-18

    Highlights: Black-Right-Pointing-Pointer A gedunin type limonoid from seeds of mangroves, 7-oxo-7-deacetoxygedunin, exhibits strong anti-osteoclastogenic activity. Black-Right-Pointing-Pointer Treatment with this limonoid results in significant decrease in expression of NFATc1 and osteoclast-related genes. Black-Right-Pointing-Pointer The mode of action of this limonoid is by inhibiting activation of the NF-{kappa}B and MAPK pathways which are activated by RANKL. -- Abstract: Osteoclasts together with osteoblasts play pivotal roles in bone remodeling. Aberrations in osteoclast differentiation and activity contribute to osteopenic disease. Osteoclasts differentiate from monocyte/macrophage progenitors, a process that is initiated by the interaction between receptor activator of NF-{kappa}B (RANK) and its ligand, RANKL. In this study, we identified 7-oxo-7-deacetoxygedunin (7-OG), a gedunin type limonoid from seeds of the mangrove Xylocarpus moluccensis, as a potent inhibitor of osteoclastogenesis. Additionally, 7-OG showed strong anti-osteoclastogenic activity with low cytotoxicity against the monocyte/macrophage progenitor cell line, RAW264.7. The IC50 for anti-osteoclastogenic activity was 4.14 {mu}M. Treatment with 7-OG completely abolished the appearance of multinucleated giant cells with tartrate-resistant acid phosphatase activity in RAW264.7 cells stimulated with RANKL. When the expression of genes related to osteoclastogenesis was investigated, a complete downregulation of NFATc1 and cathepsin K and a delayed downregulation of irf8 were observed upon 7-OG treatment in the presence of RANKL. Furthermore, treatment with this limonoid suppressed RANKL-induced activation of p38, MAPK and Erk and nuclear localization of NF-{kappa}B p65. Taken together, we present evidence indicating a plant limonoid as a novel osteoclastogenic inhibitor that could be used for osteoporosis and related conditions.

  1. Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells

    SciTech Connect (OSTI)

    Zheng, Xuemei; Li, Aiqin; Zhao, Liang; Zhou, Tengfei; Shen, Qiang; Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Peking University Health Science Center, Beijing 100191 ; Cui, Qinghua; Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Peking University Health Science Center, Beijing 100191 ; Qin, Xiaomei; Key Laboratory of Molecular Cardiovascular Science of Ministry of Education, Peking University Health Science Center, Beijing 100191

    2013-08-09

    Highlights: This is the first demonstration that miR-15a is a novel target gene of KLF4. A novel finding that KLF4 increases the expression of miR-15a in ECs and VSMCs. The novel mechanism is that KLF4 inhibits the proliferation of ECs via miR-15a. The novel mechanism is that KLF4 inhibits the proliferation of VSMCs via miR-15. miR-15a mediates the anti-angiogenic activity of KLF4. -- Abstract: While recent insights indicate that the transcription factor Krppel-like factor 4 (KLF4) is indispensable for vascular homeostasis, its exact role in proliferation and angiogenesis and how it functions remain unresolved. Thus, the aim of the present study was to evaluate the role of KLF4 in the proliferations of endothelial and vascular smooth muscle cells, as well as the angiogenesis. The overexpression of KLF4 in endothelial cells significantly impaired tube formation. KLF4 inhibited the formation of a vascular network in implanted Matrigel plugs in nude mice. Importantly, we found that KLF4 significantly upregulated the miR-15a expression in endothelial cells and vascular smooth muscle cells, and conversely, KLF4 depletion reduced the amount of miR-15a. Furthermore, KLF4 blocked cell cycle progression and decreased cyclin D1 expression in endothelial cells and vascular smooth muscle cells through the induction of miR-15a. Intriguingly, the delivery of a miR-15a antagomir to nude mice resulted in marked attenuation of the anti-angiogenic effect of KLF4. Collectively, our present study provide the first evidence that miR-15a as a direct transcriptional target of KLF4 that mediates the anti-proliferative and anti-angiogenic actions of KLF4, which indicates that KLF4 upregulation of miR-15a may represent a therapeutic option to suppress proliferative vascular disorders.

  2. siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis

    SciTech Connect (OSTI)

    Kaneko, Naoyuki; Department of Surgery, Tohoku University School of Medicine, Sendai, Miyagi 980-8575 ; Miura, Koh; Gu, Zhaodi; Karasawa, Hideaki; Ohnuma, Shinobu; Sasaki, Hiroyuki; Tsukamoto, Nobukazu; Yokoyama, Satoru; Yamamura, Akihiro; Department of Surgery, Tohoku University School of Medicine, Sendai, Miyagi 980-8575 ; Nagase, Hiroki; Shibata, Chikashi; Sasaki, Iwao; Horii, Akira

    2009-12-25

    Ndc80 has been shown to play an important role in stable microtubule-kinetochore attachment, chromosome alignment, and spindle checkpoint activation in mitosis. It is composed of two heterodimers, CDCA1-KNTC2 and SPC24-SPC25. Overexpression of CDCA1 and KNTC2 is reported to be associated with poor prognosis in non-small cell lung cancers (NSCLC), and siRNA-mediated knockdown against CDCA1 or KNTC2 has been found to inhibit cell proliferation and induction of apoptosis in NSCLC, ovarian cancer, cervical cancer and glioma. Therefore, CDCA1 and KNTC2 can be considered good candidates for molecular target therapy as well as diagnosis in some cancers. However, the role of the Ndc80 complex in colorectal and gastric cancers (CRC and GC) still remains unclear. In the present study, we used qRT-PCR to evaluate the expression levels of CDCA1, KNTC2, SPC24 and SPC25 in CRC and GC and employed siRNA-mediated knockdown to examine cell proliferation and apoptosis. mRNA overexpression of these four genes was observed in CRCs and GCs when compared with the corresponding normal mucosae. Additionally, the expression levels of tumor/normal ratios of CDCA1, KNTC2, SPC24 and SPC25 correlated with each other in CRCs. MTT assays revealed that cell growths after the siRNA-mediated knockdown of either CDCA1 or KNTC2 were significantly suppressed, and flow cytometry analyses revealed significant increases of the subG1 fractions after knockdown against both genes. Our present results suggest that expressional control of component molecules of Ndc80 can be utilized for molecular target therapy of patients with CRC and GC.

  3. Environmental Management System

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Management System Environmental Management System An Environmental Management System (EMS) is a set of processes and practices that enable an organization to reduce its...

  4. Energy Systems Integration

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Systems Integration Ben Kroposki, PhD, PE Director, Energy Systems Integration National Renewable Energy Laboratory 2 Reducing investment risk and optimizing systems in a rapidly ...

  5. Measurements of branching fraction ratios and CP-asymmetries in suppressed B-→ D(→ K+π-)K- and B-→ D(→ K+π-)π- decays

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Aaltonen, T.

    2011-08-01

    We report the first reconstruction in hadron collisions of the suppressed decays B-→ D(→ K+π-)K- and B-→ D(→ K+π-)π- decays, sensitive to the CKM phase {gamma}, using data from 7 fb-1 of integrated luminosity collected by the CDF II detector at the Tevatron collider. We reconstruct a signal for the B-→ D(→ K+π-)K- suppressed mode with a significance of 3.2 standard deviations, and measure the ratios of the suppressed to favored branching fractions R(K) = [22.0 ± 8.6(stat) ± 2.6(syst)] x 10-3, R+(K) = [42.6 ± 13.7(stat) ± 2.8(syst)] x 10-3, R-(K) = [3.8 ± 10.3(stat) ± 2.7(syst)] x 10-3more »as well as the direct CP-violating asymmetry A(K) = -0.82±0.44(stat)±0.09(syst) of this mode. Corresponding quantities for B- → D(→ K+π-)π- decay are also reported.« less

  6. Measurements of branching fraction ratios and CP-asymmetries in suppressed B-→ D(→ K+π-)K- and B-→ D(→ K+π-)π- decays

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Aaltonen, T.

    2011-08-01

    We report the first reconstruction in hadron collisions of the suppressed decays B-→ D(→ K+π-)K- and B-→ D(→ K+π-)π- decays, sensitive to the CKM phase {gamma}, using data from 7 fb-1 of integrated luminosity collected by the CDF II detector at the Tevatron collider. We reconstruct a signal for the B-→ D(→ K+π-)K- suppressed mode with a significance of 3.2 standard deviations, and measure the ratios of the suppressed to favored branching fractions R(K) = [22.0 ± 8.6(stat) ± 2.6(syst)] x 10-3, R+(K) = [42.6 ± 13.7(stat) ± 2.8(syst)] x 10-3, R-(K) = [3.8 ± 10.3(stat) ± 2.7(syst)] x 10-3more » as well as the direct CP-violating asymmetry A(K) = -0.82±0.44(stat)±0.09(syst) of this mode. Corresponding quantities for B- → D(→ K+π-)π- decay are also reported.« less

  7. Complex systems analysis of series of blackouts: cascading failure, critical points, and self-organization

    SciTech Connect (OSTI)

    Dobson, Ian [University of Wisconsin, Madison; Carreras, Benjamin A [ORNL; Lynch, Vickie E [ORNL; Newman, David E [University of Alaska

    2007-01-01

    We give an overview of a complex systems approach to large blackouts of electric power transmission systems caused by cascading failure. Instead of looking at the details of particular blackouts, we study the statistics and dynamics of series of blackouts with approximate global models. Blackout data from several countries suggest that the frequency of large blackouts is governed by a power law. The power law makes the risk of large blackouts consequential and is consistent with the power system being a complex system designed and operated near a critical point. Power system overall loading or stress relative to operating limits is a key factor affecting the risk of cascading failure. Power system blackout models and abstract models of cascading failure show critical points with power law behavior as load is increased. To explain why the power system is operated near these critical points and inspired by concepts from self-organized criticality, we suggest that power system operating margins evolve slowly to near a critical point and confirm this idea using a power system model. The slow evolution of the power system is driven by a steady increase in electric loading, economic pressures to maximize the use of the grid, and the engineering responses to blackouts that upgrade the system. Mitigation of blackout risk should account for dynamical effects in complex self-organized critical systems. For example, some methods of suppressing small blackouts could ultimately increase the risk of large blackouts.

  8. OVERCOMING THE METER BARRIER AND THE FORMATION OF SYSTEMS WITH TIGHTLY PACKED INNER PLANETS (STIPs)

    SciTech Connect (OSTI)

    Boley, A. C.; Morris, M. A.; Ford, E. B.

    2014-09-10

    We present a solution to the long outstanding meter barrier problem in planet formation theory. As solids spiral inward due to aerodynamic drag, they will enter disk regions that are characterized by high temperatures, densities, and pressures. High partial pressures of rock vapor can suppress solid evaporation, and promote collisions between partially molten solids, allowing rapid growth. This process should be ubiquitous in planet-forming disks, which may be evidenced by the abundant class of Systems with Tightly packed Inner Planets discovered by the NASA Kepler Mission.

  9. Optimization of AC Dipole Parameters for the Mu2e Extinction System

    SciTech Connect (OSTI)

    Prebys, E.; /Fermilab

    2012-05-01

    The Mu2e experiment is being planned at Fermilab to measure the rate for muons to convert to electrons in the field of an atomic nucleus with unprecedented precision. This experiment uses an 8 GeV primary proton beam consisting of short ({approx}200 nsec FW) bunches, separated by 1.7 {mu}sec. It is vital that out-of-bunch beam be suppressed at the level of 10{sup -10} or less. This poster describes the parametric analysis which was done to determine the optimum harmonics and magnet specifications for this system, as well as the implications for the beam line optics.

  10. Energy Storage Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Energy, Energy Storage, Energy Storage Systems, News, News & Events, Partnership, Renewable Energy, Research & Capabilities, Systems Analysis, Water Power Natural Energy ...

  11. A machine protection beam position monitor system

    SciTech Connect (OSTI)

    Medvedko, E.; Smith, S.; Fisher, A.

    1998-12-10

    Loss of the stored beam in an uncontrolled manner can cause damage to the PEP-II B Factory. We describe here a device which detects large beam position excursions or unexpected beam loss and triggers the beam abort system to extract the stored beam safely. The bad-orbit abort trigger beam position monitor (BOAT BPM) generates a trigger when the beam orbit is far off the center (>20 mm), or rapid beam current loss (dI/dT) is detected. The BOAT BPM averages the input signal over one turn (136 kHz). AM demodulation is used to convert input signals at 476 MHz to baseband voltages. The detected signal goes to a filter section for suppression of the revolution frequency, then on to amplifiers, dividers, and comparators for position and current measurements and triggering. The derived current signal goes to a special filter, designed to perform dI/dT monitoring at fast, medium, and slow current loss rates. The BOAT BPM prototype test results confirm the design concepts.

  12. A machine protection beam position monitor system

    SciTech Connect (OSTI)

    Medvedko, E.; Smith, S.; Fisher, A.

    1998-12-01

    Loss of the stored beam in an uncontrolled manner can cause damage to the PEP-II {ital B} Factory. We describe here a device which detects large beam position excursions or unexpected beam loss and triggers the beam abort system to extract the stored beam safely. The bad-orbit abort trigger beam position monitor (BOAT BPM) generates a trigger when the beam orbit is far off the center ({gt}20 mm), or rapid beam current loss (dI/dT) is detected. The BOAT BPM averages the input signal over one turn (136 kHz). AM demodulation is used to convert input signals at 476 MHz to baseband voltages. The detected signal goes to a filter section for suppression of the revolution frequency, then on to amplifiers, dividers, and comparators for position and current measurements and triggering. The derived current signal goes to a special filter, designed to perform dI/dT monitoring at fast, medium, and slow current loss rates. The BOAT BPM prototype test results confirm the design concepts. {copyright} {ital 1998 American Institute of Physics.}

  13. NREL: Energy Systems Integration - Power Systems Engineering

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Power Systems Engineering Power systems engineering at NREL means working with the electricity industry to optimize strategies for effectively interconnecting renewable resources and emerging energy efficiency technologies with the electric power system. Power systems engineering focuses on resolving grid integration barriers to sustainable, economic, secure, and reliable electricity based on a paradigm of high penetration of renewable energy, coordinated and intelligent cyber-control, and

  14. NERSC File Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems NERSC File Systems Overview NERSC file systems can be divided into two categories: local and global. Local file systems are only accessible on a single platform, providing best performance; global file systems are accessible on multiple platforms, simplifying data sharing between platforms. File systems are configured for different purposes. On each machine you have access to at least three different file system Home: Permanent, relatively small storage for data like source code, shell

  15. Lighting system with thermal management system

    DOE Patents [OSTI]

    Arik, Mehmet; Weaver, Stanton Earl; Stecher, Thomas Elliot; Seeley, Charles Erklin; Kuenzler, Glenn Howard; Wolfe, Jr., Charles Franklin; Utturkar, Yogen Vishwas; Sharma, Rajdeep; Prabhakaran, Satish; Icoz, Tunc

    2015-08-25

    Lighting systems having unique configurations are provided. For instance, the lighting system may include a light source, a thermal management system and driver electronics, each contained within a housing structure. The light source is configured to provide illumination visible through an opening in the housing structure. The thermal management system is configured to provide an air flow, such as a unidirectional air flow, through the housing structure in order to cool the light source. The driver electronics are configured to provide power to each of the light source and the thermal management system.

  16. Lighting system with thermal management system

    DOE Patents [OSTI]

    Arik, Mehmet; Weaver, Stanton; Stecher, Thomas; Seeley, Charles; Kuenzler, Glenn; Wolfe, Jr., Charles; Utturkar, Yogen; Sharma, Rajdeep; Prabhakaran, Satish; Icoz, Tunc

    2013-05-07

    Lighting systems having unique configurations are provided. For instance, the lighting system may include a light source, a thermal management system and driver electronics, each contained within a housing structure. The light source is configured to provide illumination visible through an opening in the housing structure. The thermal management system is configured to provide an air flow, such as a unidirectional air flow, through the housing structure in order to cool the light source. The driver electronics are configured to provide power to each of the light source and the thermal management system.

  17. Lighting system with thermal management system

    DOE Patents [OSTI]

    Arik, Mehmet; Weaver, Stanton Earl; Stecher, Thomas Elliot; Seeley, Charles Erklin; Kuenzler, Glenn Howard; Wolfe, Jr., Charles Franklin; Utturkar, Yogen Vishwas; Sharma, Rajdeep; Prabhakaran, Satish; Icoz, Tunc

    2015-02-24

    Lighting systems having unique configurations are provided. For instance, the lighting system may include a light source, a thermal management system and driver electronics, each contained within a housing structure. The light source is configured to provide illumination visible through an opening in the housing structure. The thermal management system is configured to provide an air flow, such as a unidirectional air flow, through the housing structure in order to cool the light source. The driver electronics are configured to provide power to each of the light source and the thermal management system.

  18. NETL: Energy Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Energy Systems Program Gasification Systems The Gasification Systems Program is developing advanced technologies to reduce the cost and increase the efficiency of producing syngas. Gasifipedia | Feed Systems | Gasifier Optimization | Syngas Processing | Systems Analyses | Gasification Plant Databases Advanced Combustion The Advanced Combustion Program is developing technologies and new high-temperature materials that enable electricity production using low-cost, highly efficient, oxygen-fired

  19. Using nonequilibrium dynamics to probe competing orders in a Mott-Peierls system

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Wang, Y.; Moritz, B.; Chen, C. -C.; Jia, C. J.; van Veenendaal, M.; Devereaux, T. P.

    2016-02-24

    Competition between ordered phases, and their associated phase transitions, are significant in the study of strongly correlated systems. Here, we examine one aspect, the nonequilibrium dynamics of a photoexcited Mott-Peierls system, using an effective Peierls-Hubbard model and exact diagonalization. Near a transition where spin and charge become strongly intertwined, we observe antiphase dynamics and a coupling-strength-dependent suppression or enhancement in the static structure factors. The renormalized bosonic excitations coupled to a particular photoexcited electron can be extracted, which provides an approach for characterizing the underlying bosonic modes. The results from this analysis for different electronic momenta show an uneven softeningmore » due to a stronger coupling near kF. As a result, this behavior reflects the strong link between the fermionic momenta, the coupling vertices, and ultimately, the bosonic susceptibilities when multiple phases compete for the ground state of the system.« less

  20. Hopper System Diagram

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    System Diagram System Diagram Diagram of IO architecture on Hopper Diagram of external IO services on the Hopper system Last edited: 2011-04-14 15:11:1...

  1. Systems Integration Competitive Awards

    Broader source: Energy.gov [DOE]

    Through the SunShot Systems Integration efforts, DOE is funding a range of research and development (R&D) projects to advance balance of system hardware technologies, such as racking systems...

  2. Systems and Industry Analyses

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    systems and industry analyses Go to the NETL Gasification Systems Program's Systems and Industry Analyses Studies Technology & Cost/Performance Studies NETL Gasification Systems Program's Systems and Industry Analyses Studies provide invaluable information, and help to ensure that the technologies being developed are the best ones to develop. System studies are often used to compare competing technologies, determine the best way to integrate a technology with other technologies, and predict

  3. Performance Measurement Analysis System

    Energy Science and Technology Software Center (OSTI)

    1989-06-01

    The PMAS4.0 (Performance Measurement Analysis System) is a user-oriented system designed to track the cost and schedule performance of Department of Energy (DOE) major projects (MPs) and major system acquisitions (MSAs) reporting under DOE Order 5700.4A, Project Management System. PMAS4.0 provides for the analysis of performance measurement data produced from management control systems complying with the Federal Government''s Cost and Schedule Control Systems Criteria.

  4. Strangeness suppression of qq¯ creation observed in exclusive reactions

    SciTech Connect (OSTI)

    Mestayer, M. D.; Park, K.; Adhikari, K. P.; Aghasyan, M.; Pereira, S. Anefalos; Ball, J.; Battaglieri, M.; Batourine, V.; Bedlinskiy, I.; Biselli, A. S.; Boiarinov, S.; Briscoe, W. J.; Brooks, W. K.; Burkert, V. D.; Carman, D. S.; Celentano, A.; Chandavar, S.; Charles, G.; Colaneri, L.; Cole, P. L.; Contalbrigo, M.; Cortes, O.; Crede, V.; D’Angelo, A.; Dashyan, N.; De Vita, R.; Deur, A.; Djalali, C.; Doughty, D.; Dupre, R.; Alaoui, A. El; Fassi, L. El; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fleming, J. A.; Forest, T. A.; Garillon, B.; Garçon, M.; Ghandilyan, Y.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. X.; Goetz, J. T.; Golovatch, E.; Gothe, R. W.; Griffioen, K. A.; Guegan, B.; Guidal, M.; Hakobyan, H.; Hanretty, C.; Hattawy, M.; Holtrop, M.; Hughes, S. M.; Hyde, C. E.; Ilieva, Y.; Ireland, D. G.; Jiang, H.; Jo, H. S.; Joo, K.; Keller, D.; Khandaker, M.; Kim, A.; Kim, W.; Koirala, S.; Kubarovsky, V.; Kuleshov, S. V.; Lenisa, P.; Levine, W. I.; Livingston, K.; Lu, H. Y.; MacGregor, I. J. D.; Mayer, M.; McKinnon, B.; Meyer, C. A.; Mirazita, M.; Mokeev, V.; Montgomery, R. A.; Moody, C. I.; Moutarde, H.; Movsisyan, A.; Camacho, C. Munoz; Nadel-Turonski, P.; Niccolai, S.; Niculescu, G.; Niculescu, I.; Osipenko, M.; Ostrovidov, A. I.; Pappalardo, L. L.; Paremuzyan, R.; Peng, P.; Phelps, W.; Pisano, S.; Pogorelko, O.; Pozdniakov, S.; Price, J. W.; Protopopescu, D.; Puckett, A. J. R.; Raue, B. A.; Rimal, D.; Ripani, M.; Rizzo, A.; Rosner, G.; Roy, P.; Sabatié, F.; Saini, M. S.; Schott, D.; Schumacher, R. A.; Simonyan, A.; Sokhan, D.; Strauch, S.; Sytnik, V.; Tang, W.; Tian, Ye; Ungaro, M.; Vernarsky, B.; Vlassov, A. V.; Voskanyan, H.; Voutier, E.; Walford, N. K.; Watts, D. P.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Zachariou, N.; Zhang, J.; Zhao, Z. W.; Zonta, I.

    2014-10-10

    In this study, we measured the ratios of electroproduction cross sections from a proton target for three exclusive meson-baryon final states: ΛK+, pπ0, and nπ+, with the CLAS detector at Jefferson Lab. Using a simple model of quark hadronization, we extract qq¯ creation probabilities for the first time in exclusive two-body production, in which only a single qq¯ pair is created. We observe a sizable suppression of strange quark-antiquark pairs compared to nonstrange pairs, similar to that seen in high-energy production.

  5. Planning a Microhydropower System

    Broader source: Energy.gov [DOE]

    Interested in a microhydropower system? To see if a microhydropower system would work for you, determine the vertical distance (head) available and flow (quantity) of the water.

  6. Control system design method

    DOE Patents [OSTI]

    Wilson, David G.; Robinett, III, Rush D.

    2012-02-21

    A control system design method and concomitant control system comprising representing a physical apparatus to be controlled as a Hamiltonian system, determining elements of the Hamiltonian system representation which are power generators, power dissipators, and power storage devices, analyzing stability and performance of the Hamiltonian system based on the results of the determining step and determining necessary and sufficient conditions for stability of the Hamiltonian system, creating a stable control system based on the results of the analyzing step, and employing the resulting control system to control the physical apparatus.

  7. Panasonic Ecology Systems formerly Matsushita Ecology Systems...

    Open Energy Info (EERE)

    Ecology Systems Co) Place: Kasugai, Aichi, Japan Zip: 468-8522 Sector: Solar, Wind energy Product: Japanese manufacturer of energy efficient residential and commercial...

  8. INSENS sensor system

    SciTech Connect (OSTI)

    Myers, D.W.; Baker, J.; Benzel, D.M.; Fuess, D.A.

    1993-09-29

    This paper describes an unattended ground sensor system that has been developed for the immigration and Naturalization Service (INS). The system, known as INSENS, was developed at the Lawrence Livermore National Laboratory for use by the United States Border Patrol. This system assists in the detection of illegal entry of aliens and contraband (illegal drugs, etc.) into the United States along its land borders. Key to the system is its flexible modular design which allows future software and hardware enhancements to the system without altering the fundamental architecture of the system. Elements of the system include a sensor system capable of processing signals from multiple directional probes, a repeater system, and a handheld monitor system. Seismic, passive infrared (PIR), and magnetic probes are currently supported. The design of the INSENS system elements and their performance are described.

  9. PIA - Human Resources System/Payroll System | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    System/Payroll System PIA - Human Resources System/Payroll System PIA - Human Resources System/Payroll System PDF icon PIA - Human Resources System/Payroll System More Documents & Publications PIA - INL PeopleSoft - Human Resource System PIA - INL SECURITY INFORMATION MANAGEMENT SYSTEM BUSINESS ENCLAVE PIA - Human Resources - Personal Information Change Request - Idaho National Engineering Laboratory

  10. Transportation Systems Modeling

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    TRACC RESEARCH Computational Fluid Dynamics Computational Structural Mechanics Transportation Systems Modeling TRANSPORTATION SYSTEMS MODELING Overview of TSM Transportation systems modeling research at TRACC uses the TRANSIMS (Transportation Analysis SIMulation System) traffic micro simulation code developed by the U.S. Department of Transportation (USDOT). The TRANSIMS code represents the latest generation of traffic simulation codes developed jointly under multiyear programs by USDOT, the

  11. DOE Systems Engineering Methodology

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    ......... 11 Remove the Software Platform ......and unclassified information systems (IS), regardless of software platform or size. ...

  12. Medical imaging systems

    DOE Patents [OSTI]

    Frangioni, John V

    2013-06-25

    A medical imaging system provides simultaneous rendering of visible light and diagnostic or functional images. The system may be portable, and may include adapters for connecting various light sources and cameras in open surgical environments or laparascopic or endoscopic environments. A user interface provides control over the functionality of the integrated imaging system. In one embodiment, the system provides a tool for surgical pathology.

  13. Environmental Management System

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Management System Environmental Management System An Environmental Management System is a systematic method for assessing mission activities, determining the environmental impacts of those activities, prioritizing improvements, and measuring results. May 30, 2012 The continuous improvement cycle Our Environmental Management System encourages continuous improvement of our environmental performance. Contact Environmental Communication & Public Involvement P.O. Box 1663 MS M996 Los Alamos, NM

  14. Photovoltaic systems and applications

    SciTech Connect (OSTI)

    Not Available

    1982-01-01

    Abstracts are given of presentations given at a project review meeting held at Albuquerque, NM. The proceedings cover the past accomplishments and current activities of the Photovoltaic Systems Research, Balance-of-System Technology Development and System Application Experiments Projects at Sandia National Laboratories. The status of intermediate system application experiments and residential system analysis is emphasized. Some discussion of the future of the Photovoltaic Program in general, and the Sandia projects in particular is also presented.

  15. NETL: SOFC Systems Analysis

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems Analysis NETL possesses strong systems analysis and policy support capabilities. Systems analysis support of the SOFC Program consists of conducting various energy analyses that provide input to decisions on issues such as national plans and programs, resource use, environmental and energy security policies, technology options for R&D programs and pathways to the commercialization and deployment of SOFC power systems. Here is a partial listing of SOFC systems analysis:

  16. Complex Adaptive Systems of Systems (CASoS) | NISAC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    complex physical-socio-technical systems. Examples include: tropical rain forests, agro-eco systems, cities, infrastructure, governments, political systems, education systems,...

  17. United Solar Systems Corp USSC aka Bekaert ECD Solar Systems...

    Open Energy Info (EERE)

    Systems Corp USSC aka Bekaert ECD Solar Systems LLC Jump to: navigation, search Name: United Solar Systems Corp (USSC) (aka Bekaert ECD Solar Systems LLC) Place: Middletown...

  18. LS Industrial Systems Co Ltd formerly LG Industrial Systems ...

    Open Energy Info (EERE)

    LS Industrial Systems Co Ltd formerly LG Industrial Systems Jump to: navigation, search Name: LS Industrial Systems Co Ltd (formerly LG Industrial Systems) Place: Anyang,...

  19. Ovonic Hydrogen Systems LLC formerly Texaco Ovonic Hydrogen Systems...

    Open Energy Info (EERE)

    Hydrogen Systems LLC formerly Texaco Ovonic Hydrogen Systems LLC Jump to: navigation, search Name: Ovonic Hydrogen Systems LLC (formerly Texaco Ovonic Hydrogen Systems LLC) Place:...

  20. Modeling Power Systems as Complex Adaptive Systems

    SciTech Connect (OSTI)

    Chassin, David P.; Malard, Joel M.; Posse, Christian; Gangopadhyaya, Asim; Lu, Ning; Katipamula, Srinivas; Mallow, J V.

    2004-12-30

    Physical analogs have shown considerable promise for understanding the behavior of complex adaptive systems, including macroeconomics, biological systems, social networks, and electric power markets. Many of today's most challenging technical and policy questions can be reduced to a distributed economic control problem. Indeed, economically based control of large-scale systems is founded on the conjecture that the price-based regulation (e.g., auctions, markets) results in an optimal allocation of resources and emergent optimal system control. This report explores the state-of-the-art physical analogs for understanding the behavior of some econophysical systems and deriving stable and robust control strategies for using them. We review and discuss applications of some analytic methods based on a thermodynamic metaphor, according to which the interplay between system entropy and conservation laws gives rise to intuitive and governing global properties of complex systems that cannot be otherwise understood. We apply these methods to the question of how power markets can be expected to behave under a variety of conditions.

  1. System Design | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    System Design System Design This template is used to define the system design PDF icon System Design More Documents & Publications Transition Plan Training Plan Feasibility Study ...

  2. Human factors aspects of the major upgrade to the control systems at the LANL plutonium facility

    SciTech Connect (OSTI)

    Higgins, J.C.; Pope, N.

    1997-04-01

    The Plutonium Facility (TA-55) at Los Alamos National Laboratory (LANL) has been in operation for almost 20 years. The Operations Center of TA-55 is the nerve center of the facility where operators are on duty around the clock and monitor several thousand data points using the Facility Control System (FCS). The FCS monitors, displays, alarms, and provides some limited control of several systems, including: HVAC, fire detection and suppression, radiation detection, and electrical. The FCS was failing and needed to be replaced expeditiously. This paper will discuss the human factors aspects of the design, installation, and testing of the new FCS within the above noted constraints. Particular items to be discussed include the functional requirements definition, operating experience review, screen designs, test program, operator training, and phased activation of the new circuits in an operational facility.

  3. NERSC Systems Photos

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Systems Photos NERSC Systems Photos cori panorama 1997x723 Cori (panorama) Cori closeup Cori (crop) Cori longshot Cori (wide shot) Edison Edison Edison headon Edison Last edited: 2016-04-29 11:34:48

  4. INL Autonomous Navigation System

    Energy Science and Technology Software Center (OSTI)

    2005-03-30

    The INL Autonomous Navigation System provides instructions for autonomously navigating a robot. The system permits high-speed autonomous navigation including obstacle avoidance, waypoing navigation and path planning in both indoor and outdoor environments.

  5. Absorption heat pump system

    DOE Patents [OSTI]

    Grossman, G.

    1982-06-16

    The efficiency of an absorption heat pump system is improved by conducting liquid from a second stage evaporator thereof to an auxiliary heat exchanger positioned downstream of a primary heat exchanger in the desorber of the system.

  6. Absorption heat pump system

    DOE Patents [OSTI]

    Grossman, Gershon

    1984-01-01

    The efficiency of an absorption heat pump system is improved by conducting liquid from a second stage evaporator thereof to an auxiliary heat exchanger positioned downstream of a primary heat exchanger in the desorber of the system.

  7. Injection Laser System

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Injection Laser System For each of NIF's 192 beams: The pulse shape as a function of time ... NIF's injection laser system (ILS) plays a key role in meeting these three requirements. ...

  8. NERSC Data Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    size and availability on computational systems. File System Size Edison Hopper Carver Dirac PDSF Genepool Data Transfer Nodes Global homes 246 TB Y Y Y Y Y Y Y Global project 3.8...

  9. Systems Analysis Workshop Purpose

    Broader source: Energy.gov [DOE]

    Presentation on SAW purpose to the DOE Systems Analysis Workshop held in Washington, D.C. July 28-29, 2004 to discuss and define role of systems analysis in DOE Hydrogen Program.

  10. Leasing Residential PV Systems

    SciTech Connect (OSTI)

    Rutberg, Michael; Bouza, Antonio

    2013-11-01

    The article discusses the adoption, consequences and current market status of the leasing of residential photovoltaic systems. It addresses attributed energy savings and market potential of residential system leasing.

  11. Modular optical detector system

    DOE Patents [OSTI]

    Horn, Brent A.; Renzi, Ronald F.

    2006-02-14

    A modular optical detector system. The detector system is designed to detect the presence of molecules or molecular species by inducing fluorescence with exciting radiation and detecting the emitted fluorescence. Because the system is capable of accurately detecting and measuring picomolar concentrations it is ideally suited for use with microchemical analysis systems generally and capillary chromatographic systems in particular. By employing a modular design, the detector system provides both the ability to replace various elements of the detector system without requiring extensive realignment or recalibration of the components as well as minimal user interaction with the system. In addition, the modular concept provides for the use and addition of a wide variety of components, including optical elements (lenses and filters), light sources, and detection means, to fit particular needs.

  12. Systems Analysis Workshop Agenda

    Broader source: Energy.gov [DOE]

    Agenda from DOE Systems Analysis Workshop held in Washington, D.C. July 28-29, 2004 to discuss and define role of systems analysis in DOE Hydrogen Program.

  13. Alarm Notification System

    Energy Science and Technology Software Center (OSTI)

    1995-03-12

    AN/EMS, the Alarm Notification Energy Management System, is used to monitor digital sensors in PETC buildings and to notify the safety/security operator by both a video and an audio system when a possibly hazardous condition arises.

  14. Item Management Control System

    Energy Science and Technology Software Center (OSTI)

    1993-08-06

    The Item Management Control System (IMCS) has been developed at Idaho National Engineering Laboratory to assist in organizing collections of documents using an IBM-PC or similar DOS system platform.

  15. emergency management systems

    National Nuclear Security Administration (NNSA)

    9%2A en Building International Emergency Management Systems http:nnsa.energy.govaboutusourprogramsemergencyoperationscounterterrorisminternationalprograms-1

  16. Directives System Manual

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1998-01-30

    This Manual provides detailed requirements to supplement DOE O 251.1A, Directives System, dated 1-30-98.

  17. NETL SOFC: Pressurized Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Pressurized Systems PRESSURIZED SYSTEMS (INDUSTRY TEAMS)-SOFCs demonstrate enhanced performance by increasing the cell pressure. Thus, power systems with pressurized SOFC technology have the potential to achieve efficiencies greater than 60 percent (HHV) with greater than 97 percent carbon capture, near-zero emissions, and low water usage. The Pressurized Systems key technology is developing a deeper understanding on the behavior of the state-of-the-art SOFC material set under pressurized

  18. Monitoring System Performance (Presentation)

    SciTech Connect (OSTI)

    Emery, K.; Smith, R.

    2011-02-01

    Requirements for a standard test to rate the durability of photovoltaic (PV) modules at system voltage are discussed.

  19. Lithium battery management system

    DOE Patents [OSTI]

    Dougherty, Thomas J.

    2012-05-08

    Provided is a system for managing a lithium battery system having a plurality of cells. The battery system comprises a variable-resistance element electrically connected to a cell and located proximate a portion of the cell; and a device for determining, utilizing the variable-resistance element, whether the temperature of the cell has exceeded a predetermined threshold. A method of managing the temperature of a lithium battery system is also included.

  20. System Management Software

    Energy Science and Technology Software Center (OSTI)

    2013-02-22

    MacPatch is Mac OS X system management software solution. It's used for patching, software distribution and inventory.

  1. Electronic Recordkeeping System Questionnaire

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    43.5 (04/2015) U.S. DEPARTMENT OF ENERGY Electronic Recordkeeping System Questionnaire INSTRUCTIONS: System owners should work in consultation with their organization's records contacts to ensure the accurate completion of a separate questionnaire for each electronic recordkeeping system. Federal regulations require proper address of recordkeeping requirements and disposition before approving new electronic information systems (EIS) or enhancements to existing EISes. OMB Circular A-130 requires

  2. Engineered Natural Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    petroleum systems, basin analysis, and geospatial and geostatistical approaches utilizing ... tracer investigations; measuring stream flow; and conducting geospatial investigations

  3. Enhanced Geothermal Systems

    Broader source: Energy.gov [DOE]

    Below are the project presentations and respective peer review results for Engineered Geothermal Systems, Low Temperature and Exploration Demonstration Projects.

  4. Neutrino Factory Downstream Systems

    SciTech Connect (OSTI)

    Zisman, Michael S.

    2009-12-23

    We describe the Neutrino Factory accelerator systems downstream from the target and capture area. These include the bunching and phase rotation, cooling, acceleration, and decay ring systems. We also briefly discuss the R&D program under way to develop these systems, and indicate areas where help from CERN would be invaluable.

  5. IDC System Specification Document.

    SciTech Connect (OSTI)

    Clifford, David J.

    2014-12-01

    This document contains the system specifications derived to satisfy the system requirements found in the IDC System Requirements Document for the IDC Reengineering Phase 2 project. Revisions Version Date Author/Team Revision Description Authorized by V1.0 12/2014 IDC Reengineering Project Team Initial delivery M. Harris

  6. Energy Systems Laboratory Groundbreaking

    ScienceCinema (OSTI)

    Hill, David; Otter, C.L.; Simpson, Mike; Rogers, J.W.;

    2013-05-28

    INL recently broke ground for a research facility that will house research programs for bioenergy, advanced battery systems, and new hybrid energy systems that integrate renewable, fossil and nuclear energy sources. Here's video from the groundbreaking ceremony for INL's new Energy Systems Laboratory. You can learn more about CAES research at http://www.facebook.com/idahonationallaboratory.

  7. Polymerase chain reaction system

    DOE Patents [OSTI]

    Benett, William J.; Richards, James B.; Stratton, Paul L.; Hadley, Dean R.; Milanovich, Fred P.; Belgrader, Phil; Meyer, Peter L.

    2004-03-02

    A portable polymerase chain reaction DNA amplification and detection system includes one or more chamber modules. Each module supports a duplex assay of a biological sample. Each module has two parallel interrogation ports with a linear optical system. The system is capable of being handheld.

  8. Gasification Systems Publications

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Gasification Systems Publications Table of Contents National Carbon Capture Center at the Power Systems Development Facility Reports Patents Program Presentations Solicitations Technical Presentations & Papers New program direction concepts are described in a 3-pager Radically Engineered Modular Systems Presentation 2013 Program Plan Technology Readiness Assessment (Comprehensive Report | Overview Report) Video, Images & Photos

  9. Information extraction system

    DOE Patents [OSTI]

    Lemmond, Tracy D; Hanley, William G; Guensche, Joseph Wendell; Perry, Nathan C; Nitao, John J; Kidwell, Paul Brandon; Boakye, Kofi Agyeman; Glaser, Ron E; Prenger, Ryan James

    2014-05-13

    An information extraction system and methods of operating the system are provided. In particular, an information extraction system for performing meta-extraction of named entities of people, organizations, and locations as well as relationships and events from text documents are described herein.

  10. Business System Planning Project, Preliminary System Design

    SciTech Connect (OSTI)

    EVOSEVICH, S.

    2000-10-30

    CH2M HILL Hanford Group, Inc. (CHG) is currently performing many core business functions including, but not limited to, work control, planning, scheduling, cost estimating, procurement, training, and human resources. Other core business functions are managed by or dependent on Project Hanford Management Contractors including, but not limited to, payroll, benefits and pension administration, inventory control, accounts payable, and records management. In addition, CHG has business relationships with its parent company CH2M HILL, U.S. Department of Energy, Office of River Protection and other River Protection Project contractors, government agencies, and vendors. The Business Systems Planning (BSP) Project, under the sponsorship of the CH2M HILL Hanford Group, Inc. Chief Information Officer (CIO), have recommended information system solutions that will support CHG business areas. The Preliminary System Design was developed using the recommendations from the Alternatives Analysis, RPP-6499, Rev 0 and will become the design base for any follow-on implementation projects. The Preliminary System Design will present a high-level system design, providing a high-level overview of the Commercial-Off-The-Shelf (COTS) modules and identify internal and external relationships. This document will not define data structures, user interface components (screens, reports, menus, etc.), business rules or processes. These in-depth activities will be accomplished at implementation planning time.

  11. Superconductor rotor cooling system

    DOE Patents [OSTI]

    Gamble, Bruce B.; Sidi-Yekhlef, Ahmed; Schwall, Robert E.; Driscoll, David I.; Shoykhet, Boris A.

    2004-11-02

    A system for cooling a superconductor device includes a cryocooler located in a stationary reference frame and a closed circulation system external to the cryocooler. The closed circulation system interfaces the stationary reference frame with a rotating reference frame in which the superconductor device is located. A method of cooling a superconductor device includes locating a cryocooler in a stationary reference frame, and transferring heat from a superconductor device located in a rotating reference frame to the cryocooler through a closed circulation system external to the cryocooler. The closed circulation system interfaces the stationary reference frame with the rotating reference frame.

  12. Superconductor rotor cooling system

    DOE Patents [OSTI]

    Gamble, Bruce B.; Sidi-Yekhlef, Ahmed; Schwall, Robert E.; Driscoll, David I.; Shoykhet, Boris A.

    2002-01-01

    A system for cooling a superconductor device includes a cryocooler located in a stationary reference frame and a closed circulation system external to the cryocooler. The closed circulation system interfaces the stationary reference frame with a rotating reference frame in which the superconductor device is located. A method of cooling a superconductor device includes locating a cryocooler in a stationary reference frame, and transferring heat from a superconductor device located in a rotating reference frame to the cryocooler through a closed circulation system external to the cryocooler. The closed circulation system interfaces the stationary reference frame with the rotating reference frame.

  13. FRIB cryogenic distribution system

    SciTech Connect (OSTI)

    Ganni, Venkatarao; Dixon, Kelly D.; Laverdure, Nathaniel A.; Knudsen, Peter N.; Arenius, Dana M.; Barrios, Matthew N.; Jones, S.; Johnson, M.; Casagrande, Fabio

    2014-01-01

    The Michigan State University Facility for Rare Isotope Beams (MSU-FRIB) helium distribution system has been revised to include bayonet/warm valve type disconnects between each cryomodule and the transfer line distribution system, similar to the Thomas Jefferson National Accelerator Facility (JLab) and the Spallation Neutron Source (SNS) cryogenic distribution systems. The heat loads at various temperature levels and some of the features in the design of the distribution system are outlined. The present status, the plans for fabrication, and the procurement approach for the helium distribution system are also included.

  14. Regulation of the human interleukin-2/interleukin-2 receptor system: A role for immunosuppression

    SciTech Connect (OSTI)

    Kaempfer, R.

    1994-12-31

    The strength of the cellular immune response is regulated to a large extent by the amount of interleukin-2 (IL-2) produced in response to a stimulus. The ability of lymphocytes and other cells to respond to IL-2 depends upon the expression of cell surface IL-2 receptors. Formation of a high-affinity IL-2 receptor is regulated primarily through induction of its {alpha} subunit, IL-2R{alpha}. Once formed, the IL-2R{alpha} chain turns over rapidly, rendering expression of high-affinity IL-2 receptors during the immune response dependent upon continuous activity of the IL-2R{alpha} gene. The induced expression of both human IL-2 and IL-2R{alpha} chains is sensitive to cell-mediated suppression by CD8 cells; depletion of CD8 cells leads to extensive superinduction. This coupled suppression of IL-2 and IL-2R{alpha} genes greatly increases the extend of control, and strongly limits the strength, of the signal transduced by this ligand/receptor system during an immune response. 29 refs., 3 figs.

  15. Active optical zoom system

    DOE Patents [OSTI]

    Wick, David V.

    2005-12-20

    An active optical zoom system changes the magnification (or effective focal length) of an optical imaging system by utilizing two or more active optics in a conventional optical system. The system can create relatively large changes in system magnification with very small changes in the focal lengths of individual active elements by leveraging the optical power of the conventional optical elements (e.g., passive lenses and mirrors) surrounding the active optics. The active optics serve primarily as variable focal-length lenses or mirrors, although adding other aberrations enables increased utility. The active optics can either be LC SLMs, used in a transmissive optical zoom system, or DMs, used in a reflective optical zoom system. By appropriately designing the optical system, the variable focal-length lenses or mirrors can provide the flexibility necessary to change the overall system focal length (i.e., effective focal length), and therefore magnification, that is normally accomplished with mechanical motion in conventional zoom lenses. The active optics can provide additional flexibility by allowing magnification to occur anywhere within the FOV of the system, not just on-axis as in a conventional system.

  16. Control system health test system and method

    DOE Patents [OSTI]

    Hoff, Brian D.; Johnson, Kris W.; Akasam, Sivaprasad; Baker, Thomas M.

    2006-08-15

    A method is provided for testing multiple elements of a work machine, including a control system, a component, a sub-component that is influenced by operations of the component, and a sensor that monitors a characteristic of the sub-component. In one embodiment, the method is performed by the control system and includes sending a command to the component to adjust a first parameter associated with an operation of the component. Also, the method includes detecting a sensor signal from the sensor reflecting a second parameter associated with a characteristic of the sub-component and determining whether the second parameter is acceptable based on the command. The control system may diagnose at least one of the elements of the work machine when the second parameter of the sub-component is not acceptable.

  17. Continuous recovery system for electrorefiner system

    SciTech Connect (OSTI)

    Williamson, Mark A.; Wiedmeyer, Stanley G.; Willit, James L.; Barnes, Laurel A.; Blaskovitz, Robert J.

    2014-06-10

    A continuous recovery system for an electrorefiner system may include a trough having a ridge portion and a furrow portion. The furrow portion may include a first section and a second section. An inlet and exit pipe may be connected to the trough. The inlet pipe may include an outlet opening that opens up to the first section of the furrow portion of the trough. The exit pipe may include an entrance opening that opens up to the second section of the furrow portion of the trough. A chain may extend through the inlet and exit pipes and along the furrow portion of the trough. The chain may be in a continuous loop form. A plurality of flights may be secured to the chain. Accordingly, the desired product may be continuously harvested from the electrorefiner system without having to halt the electrical power and/or remove the cathode and anode assemblies.

  18. Suppression of thermal carrier escape and efficient photo-carrier generation by two-step photon absorption in InAs quantum dot intermediate-band solar cells using a dot-in-well structure

    SciTech Connect (OSTI)

    Asahi, S.; Teranishi, H.; Kasamatsu, N.; Kada, T.; Kaizu, T.; Kita, T.

    2014-08-14

    We investigated the effects of an increase in the barrier height on the enhancement of the efficiency of two-step photo-excitation in InAs quantum dot (QD) solar cells with a dot-in-well structure. Thermal carrier escape of electrons pumped in QD states was drastically reduced by sandwiching InAs/GaAs QDs with a high potential barrier of Al{sub 0.3}Ga{sub 0.7}As. The thermal activation energy increased with the introduction of the barrier. The high potential barrier caused suppression of thermal carrier escape and helped realize a high electron density in the QD states. We observed efficient two-step photon absorption as a result of the high occupancy of the QD states at room temperature.

  19. Proposed mechanism to represent the suppression of dark current density by four orders with low energy light ion (H{sup ?}) implantation in quaternary alloy-capped InAs/GaAs quantum dot infrared photodetectors

    SciTech Connect (OSTI)

    Mandal, A.; Ghadi, H.; Mathur, K.L.; Basu, A.; Subrahmanyam, N.B.V.; Singh, P.; Chakrabarti, S.

    2013-08-01

    Graphical abstract: - Abstract: Here we propose a carrier transport mechanism for low energy H{sup ?} ions implanted InAs/GaAs quantum dot infrared photodetectors supportive of the experimental results obtained. Dark current density suppression of up to four orders was observed in the implanted quantum dot infrared photodetectors, which further demonstrates that they are effectively operational. We concentrated on determining how defect-related material and structural changes attributed to implantation helped in dark current density reduction for InAs/GaAs quantum dot infrared photodetectors. This is the first study to report the electrical carrier transport mechanism of H{sup ?} ion-implanted InAs/GaAs quantum dot infrared photodetectors.

  20. Photovoltaic System Performance

    Energy Science and Technology Software Center (OSTI)

    1989-09-25

    PVFORM4.0 is used to design a photovoltaic (PV) system using a set of design parameters which optimize the system's economic potential for the proposed location and the expected operating conditions. PVFORM3.3 has been used to determine PV system size and optimum mounting configuration. The anticipated electrical load determines the system size and the weather and the mounting configuration affect the system output. PVFORM4.0 uses program-supplied default values or their user-supplied equivalents for each of amore » large number of parameters describing the system and time-series data describing the environment to perform a series of hourly calculations to simulate the physical (photovoltaic) performance of a PV system for a one-year period. These iterative calculations sample the performance of the PV system throughout a simulated 365-day year of system operation. Within any simulated day on which system performance is sampled, the calculations are done hourly. The number of days sampled and the interval between them is determined by an input parameter. The results of these calculations are summarized on a monthly basis in output tables and an optional plot file. The program is applicable to grid interactive or stand-alone flat-plate systems. The grid interactive system is assumed to use power purchased from a local utility to supply that portion of the load not met by the simulated PV array. If the array produces more energy than can be consumed by the load, the excess energy is assumed to be sold back to the utility at a constant energy sellback price. If a stand-alone system is being modeled, the program assumes that all energy produced by the simulated PV array is first applied to the external load, and any excess is then used to charge the battery bank. Energy not consumed by the load or the batteries is considered to be wasted.« less

  1. Tool calibration system for micromachining system

    DOE Patents [OSTI]

    Miller, Donald M.

    1979-03-06

    A tool calibration system including a tool calibration fixture and a tool height and offset calibration insert for calibrating the position of a tool bit in a micromachining tool system. The tool calibration fixture comprises a yokelike structure having a triangular head, a cavity in the triangular head, and a port which communicates a side of the triangular head with the cavity. Yoke arms integral with the triangular head extend along each side of a tool bar and a tool head of the micromachining tool system. The yoke arms are secured to the tool bar to place the cavity around a tool bit which may be mounted to the end of the tool head. Three linear variable differential transformer's (LVDT) are adjustably mounted in the triangular head along an X axis, a Y axis, and a Z axis. The calibration insert comprises a main base which can be mounted in the tool head of the micromachining tool system in place of a tool holder and a reference projection extending from a front surface of the main base. Reference surfaces of the calibration insert and a reference surface on a tool bar standard length are used to set the three LVDT's of the calibration fixture to the tool reference position. These positions are transferred permanently to a mastering station. The tool calibration fixture is then used to transfer the tool reference position of the mastering station to the tool bit.

  2. THE OCCURRENCE OF WIDE-ORBIT PLANETS IN BINARY STAR SYSTEMS

    SciTech Connect (OSTI)

    Zuckerman, B.

    2014-08-20

    The occurrence of planets in binary star systems has been investigated via a variety of techniques that sample a wide range of semi-major axes, but with a preponderance of such results applicable to planets with semi-major axes less than a few astronomical units. We utilize a new methodthe presence or absence of heavy elements in the atmospheres of white dwarf starsto elucidate the frequency in main sequence binary star systems of planets with semi-major axes greater than a few astronomical units. We consider only binaries where a putative planetary system orbits one member (no circumbinary planets). For main sequence binaries where the primary star is of spectral type A or F, data in the published literature suggests that the existence of a secondary star with a semi-major axis less than about 1000AU suppresses the formation and/or long-term stability of an extended planetary system around the primary. For these spectral types and initial semi-major axis ?1000AU, extended planetary systems appear to be as common around stars in binary systems as they are around single stars.

  3. AC power systems handbook

    SciTech Connect (OSTI)

    Whitaker, J.

    1991-01-01

    Transient disturbances are what headaches are made of. Whatever you call them-spikes, surges, are power bumps-they can take your equipment down and leave you with a complicated and expensive repair job. Protection against transient disturbances is a science that demands attention to detail. This book explains how the power distribution system works, what can go wrong with it, and how to protect a facility against abnormalities. system grounding and shielding are covered in detail. Each major method of transient protection is analyzed and its relative merits discussed. The book provides a complete look at the critical elements of the ac power system. Provides a complete look at the ac power system from generation to consumption. Discusses the mechanisms that produce transient disturbances and how to protect against them. Presents diagrams to facilitate system design. Covers new areas, such as the extent of the transient disturbance problem, transient protection options, and stand-by power systems.

  4. Precision displacement reference system

    DOE Patents [OSTI]

    Bieg, Lothar F.; Dubois, Robert R.; Strother, Jerry D.

    2000-02-22

    A precision displacement reference system is described, which enables real time accountability over the applied displacement feedback system to precision machine tools, positioning mechanisms, motion devices, and related operations. As independent measurements of tool location is taken by a displacement feedback system, a rotating reference disk compares feedback counts with performed motion. These measurements are compared to characterize and analyze real time mechanical and control performance during operation.

  5. Solid source MOCVD system

    DOE Patents [OSTI]

    Hubert, B.N.; Wu, X.D.

    1998-10-13

    A system for MOCVD fabrication of superconducting and non-superconducting oxide films provides a delivery system for the feeding of metallorganic precursors for multi-component chemical vapor deposition. The delivery system can include multiple cartridges containing tightly packed precursor materials. The contents of each cartridge can be ground at a desired rate and fed together with precursor materials from other cartridges to a vaporization zone and then to a reaction zone within a deposition chamber for thin film deposition. 13 figs.

  6. Environmental Monitoring Data System

    Energy Science and Technology Software Center (OSTI)

    2004-04-21

    A set of database management tools, data processing tools, and auxiliary support functionality for processing and handling semi-structured environmental monitoring data. The system provides a flexible description language for describing the data, allowing the database to store disparate data from many different sources without changes to the configuration. The system employs XML to support unlimited named allribute/value pairs for each object defined in the system.

  7. Genomics and Systems Biology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genomics and Systems Biology Genomics and Systems Biology Los Alamos scientists perform research in functional genomics and structural genomics, and applications for such work cover diverse fields such as energy, agriculture, and environmental cleanup. Contact Us Babetta Marrone Biofuels Program Manager Email Cheryl Kuske DOE BER Biological System Science Division Program Manager Email Kirsten McCabe Emerging Threats Program Manager Email Rebecca McDonald Bioscience Communications Email "We

  8. Solid source MOCVD system

    DOE Patents [OSTI]

    Hubert, Brian N. (Yakima, WA); Wu, Xin Di (San Jose, CA)

    1998-01-01

    A system for MOCVD fabrication of superconducting and non-superconducting oxide films provides a delivery system for the feeding of metalorganic precursors for multi-component chemical vapor deposition. The delivery system can include multiple cartridges containing tightly packed precursor materials. The contents of each cartridge can be ground at a desired rate and fed together with precursor materials from other cartridges to a vaporization zone and then to a reaction zone within a deposition chamber for thin film deposition.

  9. Intelligent Transportation Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Intelligent Transportation Systems This email address is being protected from spambots. You need JavaScript enabled to view it. - TRACC Director Background The development and deployment of Intelligent Transportation Systems (ITS) in the United States is an effort of national importance. Through the use of advanced computing, control, and communication technologies, ITS promises to greatly improve the efficiency and safety of the existing surface transportation system and reduce the

  10. FNAL central email systems

    SciTech Connect (OSTI)

    Schmidt, Jack; Lilianstrom, Al; Pasetes, Ray; Hill, Kevin; /Fermilab

    2004-10-01

    The FNAL Email System is the primary point of entry for email destined for an employee or user at Fermilab. This centrally supported system is designed for reliability and availability. It uses multiple layers of protection to help ensure that: (1) SPAM messages are tagged properly; (2) All mail is inspected for viruses; and (3) Valid mail gets delivered. This system employs numerous redundant subsystems to accomplish these tasks.

  11. Amonix Photovoltaic System

    Broader source: Energy.gov [DOE]

    This photograph features the Amonix and Arizona Public Service (APS) partnership to install the world’s largest utility-scale concentrating photovoltaic (CPV) power plant in 2002. Photovoltaic (PV) systems at the APS facility use a combination of technologies. The systems in the foreground are single-axis tracking flat-plate silicon systems. Shown in the upper right are three large (35 kilowatt) Amonix CPV.

  12. Plasmatron-catalyst system

    DOE Patents [OSTI]

    Bromberg, Leslie; Cohn, Daniel R.; Rabinovich, Alexander; Alexeev, Nikolai

    2004-09-21

    A plasmatron-catalyst system. The system generates hydrogen-rich gas and comprises a plasmatron and at least one catalyst for receiving an output from the plasmatron to produce hydrogen-rich gas. In a preferred embodiment, the plasmatron receives as an input air, fuel and water/steam for use in the reforming process. The system increases the hydrogen yield and decreases the amount of carbon monoxide.

  13. Pumping System Assessment Tool

    Broader source: Energy.gov [DOE]

    The Pumping System Assessment Tool (PSAT) is a free online software tool to help industrial users assess the efficiency of pumping system operations. PSAT uses achievable pump performance data from Hydraulic Institute standards and motor performance data from the MotorMaster+ database to calculate potential energy and associated cost savings. The tool also enables users to save and retrieve log files, default values, and system curves for sharing analyses with other users.

  14. Seismic intrusion detector system

    DOE Patents [OSTI]

    Hawk, Hervey L.; Hawley, James G.; Portlock, John M.; Scheibner, James E.

    1976-01-01

    A system for monitoring man-associated seismic movements within a control area including a geophone for generating an electrical signal in response to seismic movement, a bandpass amplifier and threshold detector for eliminating unwanted signals, pulse counting system for counting and storing the number of seismic movements within the area, and a monitoring system operable on command having a variable frequency oscillator generating an audio frequency signal proportional to the number of said seismic movements.

  15. PRESSURE SYSTEM CONTROL

    DOE Patents [OSTI]

    Esselman, W.H.; Kaplan, G.M.

    1961-06-20

    The control of pressure in pressurized liquid systems, especially a pressurized liquid reactor system, may be achieved by providing a bias circuit or loop across a closed loop having a flow restriction means in the form of an orifice, a storage tank, and a pump connected in series. The subject invention is advantageously utilized where control of a reactor can be achieved by response to the temperature and pressure of the primary cooling system.

  16. Plasmatron-catalyst system

    DOE Patents [OSTI]

    Bromberg, Leslie; Cohn, Daniel R.; Rabinovich, Alexander; Alexeev, Nikolai

    2007-10-09

    A plasmatron-catalyst system. The system generates hydrogen-rich gas and comprises a plasmatron and at least one catalyst for receiving an output from the plasmatron to produce hydrogen-rich gas. In a preferred embodiment, the plasmatron receives as an input air, fuel and water/steam for use in the reforming process. The system increases the hydrogen yield and decreases the amount of carbon monoxide.

  17. Genomics and Systems Biology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Genomics and Systems Biology LANL leads the world in computational finishing of microbial genomes Read caption + In 2013, Los Alamos scientist Richard Sayre and his team genetically modified the organisms to harvest light more efficiently for maximum production. Overview of Research and Highlights Researchers at Los Alamos National Laboratory are using their renowned expertise in genomics, computation, and experimental biology as the foundation of a dynamic systems biology capability. Systems

  18. Aerosol Observing System Upgraded

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    2 Aerosol Observing System Upgraded The Aerosol Observing System (AOS) at the SGP central facility recently received maintenance and was upgraded to improve its performance. The AOS measures the properties of the aerosol particles around it. Several AOS components were removed, repaired, and calibrated to operate within specifications. The system continuously gathers information about the way minute aerosol particles interact with solar radiation. A better understanding of these interactions

  19. Kondo effect in the paramagnetic phase of CrFe alloy with the spin-density-wave suppressed by pressure or V doping

    SciTech Connect (OSTI)

    Galkin, V.Y.; de Camargo, P.C.; Budko, S.L.; Saitovitch, E.B.; Fawcett, E.

    1997-04-01

    The pressure dependence of the resistivity {rho}(T) of (Cr+2.7 at.{percent}Fe){sub 98}V{sub 2} is measured, following a previous study of the temperature dependence of {rho}(T) in the spin-density-wave (SDW) alloy system, (Cr+2.7 at.{percent} Fe){sub 1{minus}x}(V,Mn){sub x}. The minimum in {rho}(T) in the V-doped alloys seen at T{approx_gt}T{sub N} for x{gt}1 at.{percent} is found to move to lower temperatures under pressure p in the alloy containing 2 at.{percent} V, decreasing in magnitude, and eventually, as the Neel temperature T{sub N} goes to zero at p{approx}10 kbar, becoming a very shallow minimum followed by a maximum and a rapid decrease as T{r_arrow}4.2 K. This latter behavior in the paramagnetic phase is believed to be due to the Kondo effect, while the pressure dependent minimum in {rho}(T) in the SDW phase is a manifestation of impurity resonance scattering. {copyright} {ital 1997 American Institute of Physics.}

  20. MCS Systems Administration Toolkit

    Energy Science and Technology Software Center (OSTI)

    2001-09-30

    This package contains a number of systems administration utilities to assist a team of system administrators in managing a computer environment by automating routine tasks and centralizing information. Included are utilities to help install software on a network of computers and programs to make an image of a disk drive, to manage and distribute configuration files for a number of systems, and to run self-testss on systems, as well as an example of using amore » database to manage host information and various utilities.« less

  1. Training: Motor Systems

    Broader source: Energy.gov [DOE]

    Learn about the available training courses for Motor Systems: 1-day workshops.The courses are taught by highly qualified instructors who have met rigorous standards.

  2. Comprehensive Emergency Management System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2005-11-02

    The Order establishes policy and assigns roles and responsibilities for the Department of Energy (DOE) Emergency Management System. Supersedes DOE O 151.1B.

  3. Hydrogen Storage System Challenges

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    System Challenges Advanced Composite Materials for Cold and Cryogenic Hydrogen Storage Applications in Fuel Cell Electric Vehicles October 29 th , 2015 Mike Veenstra Ford Research ...

  4. Inline_System

    Energy Science and Technology Software Center (OSTI)

    2010-02-01

    Inline_System replaces a small subset of file query and manipulation commands, on computing platforms that do not offer a complete standard POSIX environment.

  5. Launching of IBenefits System

    Broader source: Energy.gov [DOE]

    Forwarding a memo on the new "IBenefits System" that was sent to Heads of Contracting Activities (HCA) and Procurement Directors (PD) for general distribution.

  6. Energy Storage Systems

    SciTech Connect (OSTI)

    Conover, David R.

    2013-12-01

    Energy Storage Systems – An Old Idea Doing New Things with New Technology article for the International Assoication of ELectrical Inspectors

  7. Equilibria in Chemical Systems

    Energy Science and Technology Software Center (OSTI)

    1992-01-01

    SOLGASMIX-PV calculates equilibrium relationships in complex chemical systems. Chemical equilibrium calculations involve finding the system composition, within certain constraints, which contains the minimum free energy. The constraints are the preservation of the masses of each element present and either constant pressure or volume. SOLGASMIX-PV can calculate equilibria in systems containing a gaseous phase, condensed phase solutions, and condensed phases of invariant and variable stoichiometry. Either a constant total gas volume or a constant total pressuremore » can be assumed. Unit activities for condensed phases and ideality for solutions are assumed, although nonideal systems can be handled provided activity coefficient relationships are available.« less

  8. Thermal Control & System Integration

    Broader source: Energy.gov [DOE]

    The thermal control and system integration activity focuses on issues such as the integration of motor and power control technologies and the development of advanced thermal control technologies....

  9. Electrical Engineer- System Protection

    Broader source: Energy.gov [DOE]

    (See Frequently Asked Questions for more information). Where would I be working? Western Area Power Administration, Upper Great Plains Region, Maintenance, North Dakota Maintenance, System...

  10. Norcal Waste Systems, Inc.

    SciTech Connect (OSTI)

    Not Available

    2002-12-01

    Fact sheet describes the LNG long-haul heavy-duty trucks at Norcal Waste Systems Inc.'s Sanitary Fill Company.

  11. Aerial Measuring System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1991-09-20

    To establish policy for the Department of Energy's (DOE) Aerial Measuring System (AMS) Program. This directive does not cancel another directive. Canceled by DOE O 153.1.

  12. Power System Dispatcher (Trainer)

    Broader source: Energy.gov [DOE]

    (See Frequently Asked Questions for more information). Where would I be working? Western Area Power Administration Rocky Mountain Region Power System Operations Transmission Switching (J4100) 5555...

  13. Electronic Recordkeeping System Questionnaire

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Questionnaire INSTRUCTIONS: System owners should work in consultation with their organization's records contacts to ensure the accurate completion of a separate questionnaire ...

  14. Climate & Earth Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sandia Home Locations Contact Us Employee Locator Energy & Climate Secure & Sustainable ... Climate & Earth Systems Climate Measurement & Modeling Arctic Climate Measurements Global ...

  15. Environmental Management System

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of those activities, prioritizing improvements, and measuring results. May 30, 2012 The continuous improvement cycle Our Environmental Management System encourages continuous...

  16. System Reconfiguration Analysis Program

    Energy Science and Technology Software Center (OSTI)

    1992-06-19

    SYSRAP is a distribution automation applications software package for assessing system reconfiguration opportunities and volt/var control on radial electric distribution feeders.

  17. Supervisory Power System Dispatcher

    Broader source: Energy.gov [DOE]

    (See Frequently Asked Questions for more information). Where would I be working? Western Area Power Administration Rocky Mountain Region Power System Operations, J4800 Transmission Scheduling &...

  18. Transient data recorder systems

    DOE Patents [OSTI]

    Gradl, David A.

    1982-01-01

    Transient data recorder systems including a high speed charge coupled device and a device exerciser, including a high speed sampler and driver circuitry.

  19. Advanced Reciprocating Engine Systems

    Broader source: Energy.gov [DOE]

    The Advanced Reciprocating Engine Systems (ARES) program is designed to promote separate but parallel engine development between the major stationary, gaseous fueled engine manufacturers in the...

  20. BN-350 "Mirror System".

    SciTech Connect (OSTI)

    Thornton, A. L.; Halbig, J. K.

    2004-01-01

    The BN-350 Unattended Monitoring System plays an important role for the Safeguards Department of the International Atomic Energy Agency (IAEA). In 1998, the Los Alamos National Laboratory, in conjunction with the IAEA and sponsored by the US Department of Energy, designed and installed an integrated multi-instrument safeguards system at the BN-350 reactor in Aktau, Kazakhstan, to monitor spent-fuel and blanket assembly conditioning and canning activities. The purpose of the system was to provide effective safeguards at this facility while reducing the manpower load on the IAEA. The system is composed of many individual nondestructive analysis and surveillance components, each having a unique function and working together to provide fully unattended measurement of spent-fuel assemblies. The BN-350 ''Mirror System'' was built to provide a similar system with like components at the IAEA Headquarters in Vienna to facilitate analysis and/or simulation of problems that might occur in the field and for training inspectors and other technical staff in preparation for their work in the field. In addition, the system is used to test new equipment and qualify new or modified software. This paper describes the main components of the Mirror System, how the components are integrated, and how the Mirror System has benefited the IAEA.

  1. Personal Computer Inventory System

    Energy Science and Technology Software Center (OSTI)

    1993-10-04

    PCIS is a database software system that is used to maintain a personal computer hardware and software inventory, track transfers of hardware and software, and provide reports.

  2. Safety system status monitoring

    SciTech Connect (OSTI)

    Lewis, J.R.; Morgenstern, M.H.; Rideout, T.H.; Cowley, P.J.

    1984-03-01

    The Pacific Northwest Laboratory has studied the safety aspects of monitoring the preoperational status of safety systems in nuclear power plants. The goals of the study were to assess for the NRC the effectiveness of current monitoring systems and procedures, to develop near-term guidelines for reducing human errors associated with monitoring safety system status, and to recommend a regulatory position on this issue. A review of safety system status monitoring practices indicated that current systems and procedures do not adequately aid control room operators in monitoring safety system status. This is true even of some systems and procedures installed to meet existing regulatory guidelines (Regulatory Guide 1.47). In consequence, this report suggests acceptance criteria for meeting the functional requirements of an adequate system for monitoring safety system status. Also suggested are near-term guidelines that could reduce the likelihood of human errors in specific, high-priority status monitoring tasks. It is recommended that (1) Regulatory Guide 1.47 be revised to address these acceptance criteria, and (2) the revised Regulatory Guide 1.47 be applied to all plants, including those built since the issuance of the original Regulatory Guide.

  3. Power System Dispatcher

    Broader source: Energy.gov [DOE]

    (See Frequently Asked Questions for more information). Where would I be working? Western Area Power Administration Rocky Mountain Region Power System Operations Transmission Switching (J4100) 5555...

  4. Hydrogen purification system

    DOE Patents [OSTI]

    Golben, Peter Mark

    2010-06-15

    The present invention provides a system to purify hydrogen involving the use of a hydride compressor and catalytic converters combined with a process controller.

  5. The Epicure Control System

    SciTech Connect (OSTI)

    Dambik, E.; Kline, D.; West, R.

    1993-09-01

    The Epicure Control System supports the Fermilab fixed target physics program. The system is distributed across a network of many different types of components. The use of multiple layers on interfaces for communication between logical tasks fits the client-server model. Physical devices are read and controlled using symbolic references entered into a database with an editor utility. The database system consists of a central portion containing all device information and optimized portions distributed among many nodes. Updates to the database are available throughout the system within minutes after being requested.

  6. Genomics and Systems Biology

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    systems: * Understanding the dynamics and treatments of viral diseases, such as HIV, influenza, and hepatitis. * Explore the complex soil community of bacteria and fungi using...

  7. Remote Systems Design & Deployment

    SciTech Connect (OSTI)

    Bailey, Sharon A.; Baker, Carl P.; Valdez, Patrick LJ

    2009-08-28

    The Pacific Northwest National Laboratory (PNNL) was tasked by Washington River Protection Solutions, LLC (WRPS) to provide information and lessons learned relating to the design, development and deployment of remote systems, particularly remote arm/manipulator systems. This report reflects PNNLs experience with remote systems and lays out the most important activities that need to be completed to successfully design, build, deploy and operate remote systems in radioactive and chemically contaminated environments. It also contains lessons learned from PNNLs work experiences, and the work of others in the national laboratory complex.

  8. System Benefits Charge

    Broader source: Energy.gov [DOE]

    New Hampshire's 1996 electric-industry restructuring legislation authorized the creation of a system benefits charge (SBC) to support energy efficiency programs and energy assistance programs for...

  9. Standard Subject Classification System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1979-08-14

    The order establishes the DOE Standard Subject Classification System for classifying documents and records by subject, including correspondence, directives, and forms.Cancels DOE O 0000.1.

  10. CONTRACTOR PURCHASING SYSTEM REVIEWS

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Page 1 APPENDIX C CONTRACTOR PURCHASING SYSTEM REVIEWS RISK ASSESSMENT MATRIX RISK CATEGORY PERFORMANCE SCHEDULE COST HIGH (3) --Performance data casts significant doubt on the ...

  11. Power Control System

    Energy Science and Technology Software Center (OSTI)

    1995-02-24

    Power Control System (PCS) is used as a real time control software package for Supervisory Control and Data Acquistion (SCADA) in an electric utility control center environment.

  12. Solar Energy Systems - Research - Systems Analysis - Smart Grid...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sunlight Systems Analysis Solar Fuels Research: Systems Analysis Smart grid photovoltaic Systems analysis photovoltaic A team of energy and grid experts from Agronne,...

  13. Quality monitored distributed voting system

    DOE Patents [OSTI]

    Skogmo, David

    1997-01-01

    A quality monitoring system can detect certain system faults and fraud attempts in a distributed voting system. The system uses decoy voters to cast predetermined check ballots. Absent check ballots can indicate system faults. Altered check ballots can indicate attempts at counterfeiting votes. The system can also cast check ballots at predetermined times to provide another check on the distributed voting system.

  14. Quality monitored distributed voting system

    DOE Patents [OSTI]

    Skogmo, D.

    1997-03-18

    A quality monitoring system can detect certain system faults and fraud attempts in a distributed voting system. The system uses decoy voters to cast predetermined check ballots. Absent check ballots can indicate system faults. Altered check ballots can indicate attempts at counterfeiting votes. The system can also cast check ballots at predetermined times to provide another check on the distributed voting system. 6 figs.

  15. Power system applications for PASC converter systems

    SciTech Connect (OSTI)

    Donnelly, M.K.; Johnson, R.M.

    1994-04-01

    This paper shows, using computer EMTP simulations, some preliminary results of applying pulse amplitude synthesis and control (PASC) technology to single-source level voltage converter system. The method can be applied to any single terminal pair source with appropriate modifications in power extraction interface and computer control program to match source and load impedance characteristics. The PASC realization as discussed here employs banks of transformers, one bank per phase, in which the primaries are connected in parallel through a switch matrix to the dc source. Two opposite polarity primaries per transformer are pulsed alternatively in time to produce an oscillatory sinusoidal output waveform. PASC conversion system capabilities to produce both leading and lagging power factor power output in single-phase and three-phase {Delta} or Y configurations are illustrated. EMTP simulations are used to demonstrate the converter capabilities. Also included are discussions regarding harmonics and potential control strategies to adapt the converter to an application or to minimize harmonics.

  16. System for controlling a hybrid energy system

    DOE Patents [OSTI]

    Hoff, Brian D.; Akasam, Sivaprasad

    2013-01-29

    A method includes identifying a first operating sequence of a repeated operation of at least one non-traction load. The method also includes determining first and second parameters respectively indicative of a requested energy and output energy of the at least one non-traction load and comparing the determined first and second parameters at a plurality of time increments of the first operating sequence. The method also includes determining a third parameter of the hybrid energy system indicative of energy regenerated from the at least one non-traction load and monitoring the third parameter at the plurality of time increments of the first operating sequence. The method also includes determining at least one of an energy deficiency or an energy surplus associated with the non-traction load of the hybrid energy system and selectively adjusting energy stored within the storage device during at least a portion of a second operating sequence.

  17. Network Information System

    Energy Science and Technology Software Center (OSTI)

    1996-05-01

    The Network Information System (NWIS) was initially implemented in May 1996 as a system in which computing devices could be recorded so that unique names could be generated for each device. Since then the system has grown to be an enterprise wide information system which is integrated with other systems to provide the seamless flow of data through the enterprise. The system Iracks data for two main entities: people and computing devices. The following aremore » the type of functions performed by NWIS for these two entities: People Provides source information to the enterprise person data repository for select contractors and visitors Generates and tracks unique usernames and Unix user IDs for every individual granted cyber access Tracks accounts for centrally managed computing resources, and monitors and controls the reauthorization of the accounts in accordance with the DOE mandated interval Computing Devices Generates unique names for all computing devices registered in the system Tracks the following information for each computing device: manufacturer, make, model, Sandia property number, vendor serial number, operating system and operating system version, owner, device location, amount of memory, amount of disk space, and level of support provided for the machine Tracks the hardware address for network cards Tracks the P address registered to computing devices along with the canonical and alias names for each address Updates the Dynamic Domain Name Service (DDNS) for canonical and alias names Creates the configuration files for DHCP to control the DHCP ranges and allow access to only properly registered computers Tracks and monitors classified security plans for stand-alone computers Tracks the configuration requirements used to setup the machine Tracks the roles people have on machines (system administrator, administrative access, user, etc...) Allows systems administrators to track changes made on the machine (both hardware and software) Generates an adjustment history of changes on selected fields« less

  18. Reproducibility in a multiprocessor system

    DOE Patents [OSTI]

    Bellofatto, Ralph A; Chen, Dong; Coteus, Paul W; Eisley, Noel A; Gara, Alan; Gooding, Thomas M; Haring, Rudolf A; Heidelberger, Philip; Kopcsay, Gerard V; Liebsch, Thomas A; Ohmacht, Martin; Reed, Don D; Senger, Robert M; Steinmacher-Burow, Burkhard; Sugawara, Yutaka

    2013-11-26

    Fixing a problem is usually greatly aided if the problem is reproducible. To ensure reproducibility of a multiprocessor system, the following aspects are proposed; a deterministic system start state, a single system clock, phase alignment of clocks in the system, system-wide synchronization events, reproducible execution of system components, deterministic chip interfaces, zero-impact communication with the system, precise stop of the system and a scan of the system state.

  19. Human-system Interfaces for Automatic Systems

    SciTech Connect (OSTI)

    OHara, J.M.; Higgins,J.; Fleger, S.; Barnes V.

    2010-11-07

    Automation is ubiquitous in modern complex systems, and commercial nuclear- power plants are no exception. Automation is applied to a wide range of functions including monitoring and detection, situation assessment, response planning, and response implementation. Automation has become a 'team player' supporting personnel in nearly all aspects of system operation. In light of its increasing use and importance in new- and future-plants, guidance is needed to conduct safety reviews of the operator's interface with automation. The objective of this research was to develop such guidance. We first characterized the important HFE aspects of automation, including six dimensions: levels, functions, processes, modes, flexibility, and reliability. Next, we reviewed literature on the effects of all of these aspects of automation on human performance, and on the design of human-system interfaces (HSIs). Then, we used this technical basis established from the literature to identify general principles for human-automation interaction and to develop review guidelines. The guidelines consist of the following seven topics: automation displays, interaction and control, automation modes, automation levels, adaptive automation, error tolerance and failure management, and HSI integration. In addition, our study identified several topics for additional research.

  20. Pipo Systems | Open Energy Information

    Open Energy Info (EERE)

    Pipo Systems Jump to: navigation, search Name: Pipo Systems Place: Spain Product: Spanish wave technology developer. References: Pipo Systems1 This article is a stub. You can...

  1. Energy Systems | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Systems Energy Systems PDF icon webinarsteamtrap20100605.pdf PDF icon Heating ... Waste Heat Management Options for Improving Industrial Process Heating Systems Reduce ...

  2. Redwood Systems | Open Energy Information

    Open Energy Info (EERE)

    Redwood Systems Place: Fremont, California Zip: 94538 Product: Redwood Systems is a Fremont-based technology developer of lighting management systems. Coordinates: 44.2605,...

  3. Energy Systems Integration Facility Map

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and data pathways across all scales. High Performance Electrical Systems Fuel Systems Thermal Systems Computing, Data Analysis, Laboratories Laboratories Laboratories and...

  4. Energistic Systems | Open Energy Information

    Open Energy Info (EERE)

    Energistic Systems Jump to: navigation, search Logo: Energistic Systems Name: Energistic Systems Address: 13551 W. 43rd Street Dr Place: Golden, Colorado Zip: 80403 Region: Rockies...

  5. Overview of locking systems

    SciTech Connect (OSTI)

    Gee, K.T.; Scott, S.H.; Wilde, M.G.; Highland, S.E.

    1993-12-01

    The purpose of this document is to present technical information that should be useful for understanding and applying locking systems for physical protection and control. There are major sections on hardware for locks, vaults, safes, and security containers. Other topics include management of lock systems and safety considerations. This document also contains notes on standards and specifications and a glossary.

  6. Environmental geographic information system.

    SciTech Connect (OSTI)

    Peek, Dennis; Helfrich, Donald Alan; Gorman, Susan

    2010-08-01

    This document describes how the Environmental Geographic Information System (EGIS) was used, along with externally received data, to create maps for the Site-Wide Environmental Impact Statement (SWEIS) Source Document project. Data quality among the various classes of geographic information system (GIS) data is addressed. A complete listing of map layers used is provided.

  7. Engineered Natural Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Engineered Natural Systems Onsite researchers at NETL develop processes, techniques, instrumentation, and relationships to collect, interpret, and disseminate data in an effort to characterize and understand the behavior of engineered natural systems. Research includes investigating theoretical and observed phenomena to support program needs and developing new concepts in the areas of analytical biogeochemistry, geology, and monitoring. Specific expertise includes: Analytical- Bio- and Geo-

  8. Purge water management system

    DOE Patents [OSTI]

    Cardoso-Neto, J.E.; Williams, D.W.

    1995-01-01

    A purge water management system is described for effectively eliminating the production of purge water when obtaining a groundwater sample from a monitoring well. In its preferred embodiment, the purge water management system comprises an expandable container, a transportation system, and a return system. The purge water management system is connected to a wellhead sampling configuration, typically permanently installed at the well site. A pump, positioned with the monitoring well, pumps groundwater through the transportation system into the expandable container, which expands in direct proportion with volume of groundwater introduced, usually three or four well volumes, yet prevents the groundwater from coming into contact with the oxygen in the air. After this quantity of groundwater has been removed from the well, a sample is taken from a sampling port, after which the groundwater in the expandable container can be returned to the monitoring well through the return system. The purge water management system prevents the purge water from coming in contact with the outside environment, especially oxygen, which might cause the constituents of the groundwater to oxidize. Therefore, by introducing the purge water back into the monitoring well, the necessity of dealing with the purge water as a hazardous waste under the Resource Conservation and Recovery Act is eliminated.

  9. Purge water management system

    DOE Patents [OSTI]

    Cardoso-Neto, Joao E.; Williams, Daniel W.

    1996-01-01

    A purge water management system for effectively eliminating the production of purge water when obtaining a groundwater sample from a monitoring well. In its preferred embodiment, the purge water management system comprises an expandable container, a transportation system, and a return system. The purge water management system is connected to a wellhead sampling configuration, typically permanently installed at the well site. A pump, positioned with the monitoring well, pumps groundwater through the transportation system into the expandable container, which expands in direct proportion with volume of groundwater introduced, usually three or four well volumes, yet prevents the groundwater from coming into contact with the oxygen in the air. After this quantity of groundwater has been removed from the well, a sample is taken from a sampling port, after which the groundwater in the expandable container can be returned to the monitoring well through the return system. The purge water management system prevents the purge water from coming in contact with the outside environment, especially oxygen, which might cause the constituents of the groundwater to oxidize. Therefore, by introducing the purge water back into the monitoring well, the necessity of dealing with the purge water as a hazardous waste under the Resource Conservation and Recovery Act is eliminated.

  10. Laser material processing system

    SciTech Connect (OSTI)

    Dantus, Marcos

    2015-04-28

    A laser material processing system and method are provided. A further aspect of the present invention employs a laser for micromachining. In another aspect of the present invention, the system uses a hollow waveguide. In another aspect of the present invention, a laser beam pulse is given broad bandwidth for workpiece modification.

  11. Systems Integration (Fact Sheet)

    SciTech Connect (OSTI)

    Not Available

    2011-10-01

    The Systems Integration (SI) subprogram works closely with industry, universities, and the national laboratories to overcome technical barriers to the large-scale deployment of solar technologies. To support these goals, the subprogram invests primarily in four areas: grid integration, technology validation, solar resource assessment, and balance of system development.

  12. Systems Integration (Fact Sheet)

    SciTech Connect (OSTI)

    DOE Solar Energy Technologies Program

    2011-10-13

    The Systems Integration (SI) subprogram works closely with industry, universities, and the national laboratories to overcome technical barriers to the large-scale deployment of solar technologies. To support these goals, the subprogram invests primarily in four areas: grid integration, technology validation, solar resource assessment, and balance of system development.

  13. Plant Phenotype Characterization System

    SciTech Connect (OSTI)

    Daniel W McDonald; Ronald B Michaels

    2005-09-09

    This report is the final scientific report for the DOE Inventions and Innovations Project: Plant Phenotype Characterization System, DE-FG36-04GO14334. The period of performance was September 30, 2004 through July 15, 2005. The project objective is to demonstrate the viability of a new scientific instrument concept for the study of plant root systems. The root systems of plants are thought to be important in plant yield and thus important to DOE goals in renewable energy sources. The scientific study and understanding of plant root systems is hampered by the difficulty in observing root activity and the inadequacy of existing root study instrumentation options. We have demonstrated a high throughput, non-invasive, high resolution technique for visualizing plant root systems in-situ. Our approach is based upon low-energy x-ray radiography and the use of containers and substrates (artificial soil) which are virtually transparent to x-rays. The system allows us to germinate and grow plant specimens in our containers and substrates and to generate x-ray images of the developing root system over time. The same plant can be imaged at different times in its development. The system can be used for root studies in plant physiology, plant morphology, plant breeding, plant functional genomics and plant genotype screening.

  14. Geothermal Data Systems

    Broader source: Energy.gov [DOE]

    The U.S. Department of Energy (DOE) Geothermal Technologies Office (GTO) has designed and tested a comprehensive, federated information system that will make geothermal data widely available. This new National Geothermal Data System (NGDS) will provide access to all types of geothermal data to enable geothermal analysis and widespread public use, thereby reducing the risk of geothermal energy development.

  15. Metadata management staging system

    Energy Science and Technology Software Center (OSTI)

    2013-08-01

    Django application providing a user-interface for building a file and metadata management system. An evolution of our Node.js and CouchDb metadata management system. This one focuses on server functionality and uses a well-documented, rational and REST-ful API for data access.

  16. Secure video communications system

    DOE Patents [OSTI]

    Smith, Robert L.

    1991-01-01

    A secure video communications system having at least one command network formed by a combination of subsystems. The combination of subsystems to include a video subsystem, an audio subsystem, a communications subsystem, and a control subsystem. The video communications system to be window driven and mouse operated, and having the ability to allow for secure point-to-point real-time teleconferencing.

  17. Heterodyne laser diagnostic system

    DOE Patents [OSTI]

    Globig, Michael A.; Johnson, Michael A.; Wyeth, Richard W.

    1990-01-01

    The heterodyne laser diagnostic system includes, in one embodiment, an average power pulsed laser optical spectrum analyzer for determining the average power of the pulsed laser. In another embodiment, the system includes a pulsed laser instantaneous optical frequency measurement for determining the instantaneous optical frequency of the pulsed laser.

  18. Thermoelectrochemical system and method

    DOE Patents [OSTI]

    Ludwig, Frank A.; Townsend, Carl W.; Eliash, Bruce M.

    1995-11-28

    A thermal electrochemical system in which an electrical current is generated between a cathode immersed in a concentrated aqueous solution of phosphoric acid and an anode immersed in a molten salt solution of ammonium phosphate and monohydric ammonium phosphate. Reactants consumed at the electrodes during the electrochemical reaction are thermochemically regenerated and recycled to the electrodes to provide continuous operation of the system.

  19. Charge exchange system

    DOE Patents [OSTI]

    Anderson, Oscar A.

    1978-01-01

    An improved charge exchange system for substantially reducing pumping requirements of excess gas in a controlled thermonuclear reactor high energy neutral beam injector. The charge exchange system utilizes a jet-type blanket which acts simultaneously as the charge exchange medium and as a shield for reflecting excess gas.

  20. Radiation detection system

    DOE Patents [OSTI]

    Franks, Larry A.; Lutz, Stephen S.; Lyons, Peter B.

    1981-01-01

    A radiation detection system including a radiation-to-light converter and fiber optic wave guides to transmit the light to a remote location for processing. The system utilizes fluors particularly developed for use with optical fibers emitting at wavelengths greater than about 500 nm and having decay times less than about 10 ns.

  1. Grinding Wheel System

    DOE Patents [OSTI]

    Malkin, Stephen (Amherst, MA); Gao, Robert (Amherst, MA); Guo, Changsheng (South Windsor, CT); Varghese, Biju (Worthington, OH); Pathare, Sumukh (Waltham, MA)

    2003-08-05

    A grinding wheel system includes a grinding wheel with at least one embedded sensor. The system also includes an adapter disk containing electronics that process signals produced by each embedded sensor and that transmits sensor information to a data processing platform for further processing of the transmitted information.

  2. Grinding Wheel System

    DOE Patents [OSTI]

    Malkin, Stephen (Amherst, MA); Gao, Robert (Amherst, MA); Guo, Changsheng (South Windsor, CT); Varghese, Biju (Worthington, OH); Pathare, Sumukh (Waltham, MA)

    2006-01-10

    A grinding wheel system includes a grinding wheel with at least one embedded sensor. The system also includes an adapter disk containing electronics that process signals produced by each embedded sensor and that transmits sensor information to a data processing platform for further processing of the transmitted information.

  3. Filter service system

    DOE Patents [OSTI]

    Sellers, Cheryl L.; Nordyke, Daniel S.; Crandell, Richard A.; Tomlins, Gregory; Fei, Dong; Panov, Alexander; Lane, William H.; Habeger, Craig F.

    2008-12-09

    According to an exemplary embodiment of the present disclosure, a system for removing matter from a filtering device includes a gas pressurization assembly. An element of the assembly is removably attachable to a first orifice of the filtering device. The system also includes a vacuum source fluidly connected to a second orifice of the filtering device.

  4. Novel microsatellite control system

    SciTech Connect (OSTI)

    Moore, K.R.; Frigo, J.R.; Tilden, M.W.

    1996-12-31

    The authors are developing extremely simple yet quite capable analog pulse-coded neural networks for smaller-faster-cheaper spacecraft attitude and control systems. They will demonstrate a prototype microsatellite that uses the novel control system to autonomously stabilize itself in the ambient magnetic field and point itself at the brightest available light source.

  5. Portable modular detection system

    DOE Patents [OSTI]

    Brennan, James S. (Rodeo, CA); Singh, Anup (Danville, CA); Throckmorton, Daniel J. (Tracy, CA); Stamps, James F. (Livermore, CA)

    2009-10-13

    Disclosed herein are portable and modular detection devices and systems for detecting electromagnetic radiation, such as fluorescence, from an analyte which comprises at least one optical element removably attached to at least one alignment rail. Also disclosed are modular detection devices and systems having an integrated lock-in amplifier and spatial filter and assay methods using the portable and modular detection devices.

  6. Planning cogeneration systems

    SciTech Connect (OSTI)

    Limaye, D.

    1984-01-01

    Major factors and considerations in the planning and evaluation of cogeneration systems are explained here. Coverage is provided of prefeasibility assessment, technical and economic feasibility evaluation, computerized systems design, cogeneration technologies and applications, and non-conventional technologies. Also discussed are fuel availability and price trends, financing and risk management in cogeneration projects, and practical considerations in cogeneration implementation.

  7. Heavy Vehicle Systems

    SciTech Connect (OSTI)

    Sid Diamond; Richard Wares; Jules Routbort

    2000-04-11

    Heavy Vehicle (HV) systems are a necessary component of achieving OHVT goals. Elements are in place for a far-ranging program: short, intermediate, and long-term. Solicitation will bring industrial input and support. Future funding trend is positive, outlook for HV systems is good.

  8. Comprehensive Emergency Management System

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    2000-11-01

    To establish policy and to assign and describe roles and responsibilities for the Department of Energy (DOE) Emergency Management System. The Emergency Management System provides the framework for development, coordination, control, and direction of all emergency planning, preparedness, readiness assurance, response, and recovery actions. Canceled by DOE O 151.1B. Cancels DOE O 151.1.

  9. Balance-of-System Equipment Required for Renewable Energy Systems...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Balance-of-System Equipment Required for Renewable Energy Systems Balance-of-System Equipment Required for Renewable Energy Systems July 2, 2012 - 8:21pm Addthis Both...

  10. An automated vacuum system

    SciTech Connect (OSTI)

    Atkins, W.H. ); Vaughn, G.D. ); Bridgman, C. )

    1991-01-01

    Software tools available with the Ground Test Accelerator (GTA) control system provide the capability to express a control problem as a finite state machine. System states and transitions are expressed in terms of accelerator parameters and actions are taken based on state transitions. This is particularly useful for sequencing operations which are modal in nature or are unwieldy when implemented with conventional programming. State diagrams are automatically translated into code which is executed by the control system. These tools have been applied to the vacuum system for the GTA accelerator to implement automatic sequencing of operations. With a single request, the operator may initiate a complete pump-down sequence. He can monitor the progress and is notified if an anomaly occurs requiring intervention. The operator is not required to have detailed knowledge of the vacuum system and is protected from taking inappropriate actions. 1 ref., 6 figs.

  11. Electrochemical thermodynamic measurement system

    DOE Patents [OSTI]

    Reynier, Yvan; Yazami, Rachid; Fultz, Brent T.

    2009-09-29

    The present invention provides systems and methods for accurately characterizing thermodynamic and materials properties of electrodes and electrochemical energy storage and conversion systems. Systems and methods of the present invention are configured for simultaneously collecting a suite of measurements characterizing a plurality of interconnected electrochemical and thermodynamic parameters relating to the electrode reaction state of advancement, voltage and temperature. Enhanced sensitivity provided by the present methods and systems combined with measurement conditions that reflect thermodynamically stabilized electrode conditions allow very accurate measurement of thermodynamic parameters, including state functions such as the Gibbs free energy, enthalpy and entropy of electrode/electrochemical cell reactions, that enable prediction of important performance attributes of electrode materials and electrochemical systems, such as the energy, power density, current rate and the cycle life of an electrochemical cell.

  12. Oil field management system

    DOE Patents [OSTI]

    Fincke, James R.

    2003-09-23

    Oil field management systems and methods for managing operation of one or more wells producing a high void fraction multiphase flow. The system includes a differential pressure flow meter which samples pressure readings at various points of interest throughout the system and uses pressure differentials derived from the pressure readings to determine gas and liquid phase mass flow rates of the high void fraction multiphase flow. One or both of the gas and liquid phase mass flow rates are then compared with predetermined criteria. In the event such mass flow rates satisfy the predetermined criteria, a well control system implements a correlating adjustment action respecting the multiphase flow. In this way, various parameters regarding the high void fraction multiphase flow are used as control inputs to the well control system and thus facilitate management of well operations.

  13. Adsorption Refrigeration System

    SciTech Connect (OSTI)

    Wang, Kai; Vineyard, Edward Allan

    2011-01-01

    Adsorption refrigeration is an environmentally friendly cooling technology which could be driven by recovered waste heat or low-grade heat such as solar energy. In comparison with absorption system, an adsorption system has no problems such as corrosion at high temperature and salt crystallization. In comparison with vapor compression refrigeration system, it has the advantages of simple control, no moving parts and less noise. This paper introduces the basic theory of adsorption cycle as well as the advanced adsorption cycles such as heat and mass recovery cycle, thermal wave cycle and convection thermal wave cycle. The types, characteristics, advantages and drawbacks of different adsorbents used in adsorption refrigeration systems are also summarized. This article will increase the awareness of this emerging cooling technology among the HVAC engineers and help them select appropriate adsorption systems in energy-efficient building design.

  14. Basic fluid system trainer

    DOE Patents [OSTI]

    Semans, Joseph P.; Johnson, Peter G.; LeBoeuf, Jr., Robert F.; Kromka, Joseph A.; Goron, Ronald H.; Hay, George D.

    1993-01-01

    A trainer, mounted and housed within a mobile console, is used to teach and reinforce fluid principles to students. The system trainer has two centrifugal pumps, each driven by a corresponding two-speed electric motor. The motors are controlled by motor controllers for operating the pumps to circulate the fluid stored within a supply tank through a closed system. The pumps may be connected in series or in parallel. A number of valves are also included within the system to effect different flow paths for the fluid. In addition, temperature and pressure sensing instruments are installed throughout the closed system for measuring the characteristics of the fluid, as it passes through the different valves and pumps. These measurements are indicated on a front panel mounted to the console, as a teaching aid, to allow the students to observe the characteristics of the system.

  15. Data acquisition system

    DOE Patents [OSTI]

    Shapiro, Stephen L.; Mani, Sudhindra; Atlas, Eugene L.; Cords, Dieter H. W.; Holbrook, Britt

    1997-01-01

    A data acquisition circuit for a particle detection system that allows for time tagging of particles detected by the system. The particle detection system screens out background noise and discriminate between hits from scattered and unscattered particles. The detection system can also be adapted to detect a wide variety of particle types. The detection system utilizes a particle detection pixel array, each pixel containing a back-biased PIN diode, and a data acquisition pixel array. Each pixel in the particle detection pixel array is in electrical contact with a pixel in the data acquisition pixel array. In response to a particle hit, the affected PIN diodes generate a current, which is detected by the corresponding data acquisition pixels. This current is integrated to produce a voltage across a capacitor, the voltage being related to the amount of energy deposited in the pixel by the particle. The current is also used to trigger a read of the pixel hit by the particle.

  16. LM Records Handling System (LMRHS01) - Electronic Records Keeping System,

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Office of Legacy Management, | Department of Energy System (LMRHS01) - Electronic Records Keeping System, Office of Legacy Management, LM Records Handling System (LMRHS01) - Electronic Records Keeping System, Office of Legacy Management, LM Records Handling System (LMRHS01) - Electronic Records Keeping System, Office of Legacy Management, PDF icon LM Records Handling System (LMRHS01) - Electronic Records Keeping System, Office of Legacy Management, More Documents & Publications LM

  17. Common Control System Vulnerability

    SciTech Connect (OSTI)

    Trent Nelson

    2005-12-01

    The Control Systems Security Program and other programs within the Idaho National Laboratory have discovered a vulnerability common to control systems in all sectors that allows an attacker to penetrate most control systems, spoof the operator, and gain full control of targeted system elements. This vulnerability has been identified on several systems that have been evaluated at INL, and in each case a 100% success rate of completing the attack paths that lead to full system compromise was observed. Since these systems are employed in multiple critical infrastructure sectors, this vulnerability is deemed common to control systems in all sectors. Modern control systems architectures can be considered analogous to today's information networks, and as such are usually approached by attackers using a common attack methodology to penetrate deeper and deeper into the network. This approach often is composed of several phases, including gaining access to the control network, reconnaissance, profiling of vulnerabilities, launching attacks, escalating privilege, maintaining access, and obscuring or removing information that indicates that an intruder was on the system. With irrefutable proof that an external attack can lead to a compromise of a computing resource on the organization's business local area network (LAN), access to the control network is usually considered the first phase in the attack plan. Once the attacker gains access to the control network through direct connections and/or the business LAN, the second phase of reconnaissance begins with traffic analysis within the control domain. Thus, the communications between the workstations and the field device controllers can be monitored and evaluated, allowing an attacker to capture, analyze, and evaluate the commands sent among the control equipment. Through manipulation of the communication protocols of control systems (a process generally referred to as ''reverse engineering''), an attacker can then map out the control system processes and functions. With the detailed knowledge of how the control data functions, as well as what computers and devices communicate using this data, the attacker can use a well known Man-in-the-Middle attack to perform malicious operations virtually undetected. The control systems assessment teams have used this method to gather enough information about the system to craft an attack that intercepts and changes the information flow between the end devices (controllers) and the human machine interface (HMI and/or workstation). Using this attack, the cyber assessment team has been able to demonstrate complete manipulation of devices in control systems while simultaneously modifying the data flowing back to the operator's console to give false information of the state of the system (known as ''spoofing''). This is a very effective technique for a control system attack because it allows the attacker to manipulate the system and the operator's situational awareness of the perceived system status. The three main elements of this attack technique are: (1) network reconnaissance and data gathering, (2) reverse engineering, and (3) the Man-in-the-Middle attack. The details of this attack technique and the mitigation techniques are discussed.

  18. Los Alamos National Laboratory`s Mobile Real Time Radiography System

    SciTech Connect (OSTI)

    Vigil, J.; Taggart, D.; Betts, S.; Mendez, J.; Rael, C.; Martinez, F.

    1997-01-01

    A 450-KeV Mobile Real Time Radiography (RTR) System was delivered to Los Alamos National Laboratory (LANL) in January 1996. It was purchased to inspect containers of radioactive waste produced at (LANL). Since its delivery it has been used to radiograph greater than 600 drums of radioactive waste at various LANL sites. It has the capability of inspecting waste containers of various sizes. It has three independent X-Ray acquisition formats. The primary system used is a 12 in. image intensifier, the second is a 36 in. linear diode array (LDA) and the last is an open system. It is fully self contained with on board generator, HVAC and a fire suppression system. It is on a 53 ft long X 8 ft. wide X 14 ft. high trailer that can be moved over any highway requiring only a easily obtainable overweight permit because it weighs approximately 38 tons. It was built to conform to industry standards for a cabinet system which does not require an exclusion zone. The fact that this unit is mobile has allowed us to operate where the waste is stored, rather than having to move the waste to a fixed facility.

  19. Control system design guide

    SciTech Connect (OSTI)

    Sellers, David; Friedman, Hannah; Haasl, Tudi; Bourassa, Norman; Piette, Mary Ann

    2003-05-01

    The ''Control System Design Guide'' (Design Guide) provides methods and recommendations for the control system design process and control point selection and installation. Control systems are often the most problematic system in a building. A good design process that takes into account maintenance, operation, and commissioning can lead to a smoothly operating and efficient building. To this end, the Design Guide provides a toolbox of templates for improving control system design and specification. HVAC designers are the primary audience for the Design Guide. The control design process it presents will help produce well-designed control systems that achieve efficient and robust operation. The spreadsheet examples for control valve schedules, damper schedules, and points lists can streamline the use of the control system design concepts set forth in the Design Guide by providing convenient starting points from which designers can build. Although each reader brings their own unique questions to the text, the Design Guide contains information that designers, commissioning providers, operators, and owners will find useful.

  20. Medical imaging systems

    DOE Patents [OSTI]

    Frangioni, John V.

    2012-07-24

    A medical imaging system provides simultaneous rendering of visible light and fluorescent images. The system may employ dyes in a small-molecule form that remains in a subject's blood stream for several minutes, allowing real-time imaging of the subject's circulatory system superimposed upon a conventional, visible light image of the subject. The system may also employ dyes or other fluorescent substances associated with antibodies, antibody fragments, or ligands that accumulate within a region of diagnostic significance. In one embodiment, the system provides an excitation light source to excite the fluorescent substance and a visible light source for general illumination within the same optical guide that is used to capture images. In another embodiment, the system is configured for use in open surgical procedures by providing an operating area that is closed to ambient light. More broadly, the systems described herein may be used in imaging applications where a visible light image may be usefully supplemented by an image formed from fluorescent emissions from a fluorescent substance that marks areas of functional interest.

  1. Downhole telemetry system

    DOE Patents [OSTI]

    Normann, Randy A. (Albuquerque, NM); Kadlec, Emil R. (Albuquerque, NM)

    1994-01-01

    A downhole telemetry system is described for optically communicating to the surface operating parameters of a drill bit during ongoing drilling operations. The downhole telemetry system includes sensors mounted with a drill bit for monitoring at least one operating parameter of the drill bit and generating a signal representative thereof. The downhole telemetry system includes means for transforming and optically communicating the signal to the surface as well as means at the surface for producing a visual display of the optically communicated operating parameters of the drill bit.

  2. Downhole telemetry system

    DOE Patents [OSTI]

    Normann, R.A.; Kadlec, E.R.

    1994-11-08

    A downhole telemetry system is described for optically communicating to the surface operating parameters of a drill bit during ongoing drilling operations. The downhole telemetry system includes sensors mounted with a drill bit for monitoring at least one operating parameter of the drill bit and generating a signal representative thereof. The downhole telemetry system includes means for transforming and optically communicating the signal to the surface as well as means at the surface for producing a visual display of the optically communicated operating parameters of the drill bit. 7 figs.

  3. Oxford System 400

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Oxford Plasmalab System 400 Sputtering System For questions concerning this machines capabilities, please contact Varshni Singh, at 578-0248. ecr.jpg (48456 bytes) &nbsp: ecr1.jpg (68318 bytes) The Oxford System 400 produces uniform metallic films for use in the LIGA process at CAMD. This tool is equipped with two DC and one RF magnetron sputter targets for deposition of Cu, Ni, and Ti respectively. A load lock and rotating table allow deposition of up to four wafers during a single run.

  4. Nuclear medicine imaging system

    DOE Patents [OSTI]

    Bennett, G.W.; Brill, A.B.; Bizais, Y.J.C.; Rowe, R.W.; Zubal, I.G.

    1983-03-11

    It is an object of this invention to provide a nuclear imaging system having the versatility to do positron annihilation studies, rotating single or opposed camera gamma emission studies, and orthogonal gamma emission studies. It is a further object of this invention to provide an imaging system having the capability for orthogonal dual multipinhole tomography. It is another object of this invention to provide a nuclear imaging system in which all available energy data, as well as patient physiological data, are acquired simultaneously in list mode.

  5. Absorption heat pump system

    DOE Patents [OSTI]

    Grossman, Gershon; Perez-Blanco, Horacio

    1984-01-01

    An improvement in an absorption heat pump cycle is obtained by adding adiabatic absorption and desorption steps to the absorber and desorber of the system. The adiabatic processes make it possible to obtain the highest temperature in the absorber before any heat is removed from it and the lowest temperature in the desorber before heat is added to it, allowing for efficient utilization of the thermodynamic availability of the heat supply stream. The improved system can operate with a larger difference between high and low working fluid concentrations, less circulation losses, and more efficient heat exchange than a conventional system.

  6. Portable pathogen detection system

    DOE Patents [OSTI]

    Colston, Billy W.; Everett, Matthew; Milanovich, Fred P.; Brown, Steve B.; Vendateswaran, Kodumudi; Simon, Jonathan N.

    2005-06-14

    A portable pathogen detection system that accomplishes on-site multiplex detection of targets in biological samples. The system includes: microbead specific reagents, incubation/mixing chambers, a disposable microbead capture substrate, and an optical measurement and decoding arrangement. The basis of this system is a highly flexible Liquid Array that utilizes optically encoded microbeads as the templates for biological assays. Target biological samples are optically labeled and captured on the microbeads, which are in turn captured on an ordered array or disordered array disposable capture substrate and then optically read.

  7. Distributed Optimization System

    DOE Patents [OSTI]

    Hurtado, John E.; Dohrmann, Clark R.; Robinett, III, Rush D.

    2004-11-30

    A search system and method for controlling multiple agents to optimize an objective using distributed sensing and cooperative control. The search agent can be one or more physical agents, such as a robot, and can be software agents for searching cyberspace. The objective can be: chemical sources, temperature sources, radiation sources, light sources, evaders, trespassers, explosive sources, time dependent sources, time independent sources, function surfaces, maximization points, minimization points, and optimal control of a system such as a communication system, an economy, a crane, and a multi-processor computer.

  8. Eliza File Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Eliza File Systems Eliza File Systems Storage at PDSF is organized by group and available to all the nodes in PDSF. Please note that files on these file systems are not backed up. It is the responsibility of users to back up their files themselves as necessary. Over the years at PDSF there have been incidents which resulted in a loss of data from disk, often related to aging hardware. You can display the UGE io units with the command "qconf -se global". Disk Vault Experiments SGE io

  9. Shock destruction armor system

    DOE Patents [OSTI]

    Froeschner, Kenneth E.

    1993-01-01

    A shock destruction armor system is constructed and arranged to destroy the force of impact of a projectile by shock hydrodynamics. The armor system is designed to comprise a plurality of superimposed armor plates each preferably having a thickness less than five times the projectile's diameter and are preferably separated one-from-another by a distance at least equal to one-half of the projectile's diameter. The armor plates are effective to hydrodynamically and sequentially destroy the projectile. The armor system is particularly adapted for use on various military vehicles, such as tanks, aircraft and ships.

  10. Power management system

    DOE Patents [OSTI]

    Algrain, Marcelo C.; Johnson, Kris W.; Akasam, Sivaprasad; Hoff, Brian D.

    2007-10-02

    A method of managing power resources for an electrical system of a vehicle may include identifying enabled power sources from among a plurality of power sources in electrical communication with the electrical system and calculating a threshold power value for the enabled power sources. A total power load placed on the electrical system by one or more power consumers may be measured. If the total power load exceeds the threshold power value, then a determination may be made as to whether one or more additional power sources is available from among the plurality of power sources. At least one of the one or more additional power sources may be enabled, if available.

  11. Control and optimization system

    DOE Patents [OSTI]

    Xinsheng, Lou

    2013-02-12

    A system for optimizing a power plant includes a chemical loop having an input for receiving an input parameter (270) and an output for outputting an output parameter (280), a control system operably connected to the chemical loop and having a multiple controller part (230) comprising a model-free controller. The control system receives the output parameter (280), optimizes the input parameter (270) based on the received output parameter (280), and outputs an optimized input parameter (270) to the input of the chemical loop to control a process of the chemical loop in an optimized manner.

  12. Cyberspace security system

    DOE Patents [OSTI]

    Abercrombie, Robert K; Sheldon, Frederick T; Ferragut, Erik M

    2014-06-24

    A system evaluates reliability, performance and/or safety by automatically assessing the targeted system's requirements. A cost metric quantifies the impact of failures as a function of failure cost per unit of time. The metrics or measurements may render real-time (or near real-time) outcomes by initiating active response against one or more high ranked threats. The system may support or may be executed in many domains including physical domains, cyber security domains, cyber-physical domains, infrastructure domains, etc. or any other domains that are subject to a threat or a loss.

  13. Computerized procedures system

    DOE Patents [OSTI]

    Lipner, Melvin H.; Mundy, Roger A.; Franusich, Michael D.

    2010-10-12

    An online data driven computerized procedures system that guides an operator through a complex process facility's operating procedures. The system monitors plant data, processes the data and then, based upon this processing, presents the status of the current procedure step and/or substep to the operator. The system supports multiple users and a single procedure definition supports several interface formats that can be tailored to the individual user. Layered security controls access privileges and revisions are version controlled. The procedures run on a server that is platform independent of the user workstations that the server interfaces with and the user interface supports diverse procedural views.

  14. Electrolytic oxide reduction system

    DOE Patents [OSTI]

    Wiedmeyer, Stanley G; Barnes, Laurel A; Williamson, Mark A; Willit, James L; Berger, John F

    2015-04-28

    An electrolytic oxide reduction system according to a non-limiting embodiment of the present invention may include a plurality of anode assemblies, a plurality of cathode assemblies, and a lift system configured to engage the anode and cathode assemblies. The cathode assemblies may be alternately arranged with the anode assemblies such that each cathode assembly is flanked by two anode assemblies. The lift system may be configured to selectively engage the anode and cathode assemblies so as to allow the simultaneous lifting of any combination of the anode and cathode assemblies (whether adjacent or non-adjacent).

  15. Radiation Safety System

    SciTech Connect (OSTI)

    Vylet, Vaclav; Liu, James C.; Walker, Lawrence S.; /Los Alamos

    2012-04-04

    The goal of this work is to provide an overview of a Radiation safety system (RSS) designed for protection from prompt radiation hazard at accelerator facilities. RSS design parameters, functional requirements and constraints are derived from hazard analysis and risk assessment undertaken in the design phase of the facility. The two main subsystems of a RSS are access control system (ACS) and radiation control system (RCS). In this text, a common approach to risk assessment, typical components of ACS and RCS, desirable features and general design principles applied to RSS are described.

  16. Tokamak Systems Code

    SciTech Connect (OSTI)

    Reid, R.L.; Barrett, R.J.; Brown, T.G.; Gorker, G.E.; Hooper, R.J.; Kalsi, S.S.; Metzler, D.H.; Peng, Y.K.M.; Roth, K.E.; Spampinato, P.T.

    1985-03-01

    The FEDC Tokamak Systems Code calculates tokamak performance, cost, and configuration as a function of plasma engineering parameters. This version of the code models experimental tokamaks. It does not currently consider tokamak configurations that generate electrical power or incorporate breeding blankets. The code has a modular (or subroutine) structure to allow independent modeling for each major tokamak component or system. A primary benefit of modularization is that a component module may be updated without disturbing the remainder of the systems code as long as the imput to or output from the module remains unchanged.

  17. Dehumidification -- Closed loop systems

    SciTech Connect (OSTI)

    Wyatt, C.H.; Crowe, A.R.

    1996-05-01

    Dehumidification is the removal of water from the air. Dehumidification equipment treats the ambient air before it is introduced to the enclosure. A closed loop system is one that theoretically routes all the air exiting an enclosure through the appropriate filter media and treatment equipment and then returns it to the enclosure. By establishing a closed loop system, the ``treated`` air is continuously processed, which improves the efficiency of this operation. The generic types of dehumidification equipment and their application in a closed loop system will be presented. This article will deal solely with the use of dehumidification and other related equipment used to control the environment within the work enclosure.

  18. Steam System Modeler

    Broader source: Energy.gov [DOE]

    The Steam System Modeler allows you to create up to a 3-pressure-header basic model of your current steam system. A second model can then be created by adjusting a series of characteristics simulating technical or input changes. This allows you to see how each component and adjustment impacts the others and what changes may be most beneficial to increasing the overall efficiency and stability of the system. An interactive diagram is provided for each model and includes comprehensive steam properties and operational details for clarity and ease of use.

  19. Strongly modified four-wave mixing in a coupled semiconductor quantum dot-metal nanoparticle system

    SciTech Connect (OSTI)

    Paspalakis, Emmanuel; Evangelou, Sofia; Kosionis, Spyridon G.; Terzis, Andreas F.

    2014-02-28

    We study the four-wave mixing effect in a coupled semiconductor quantum dot-spherical metal nanoparticle structure. Depending on the values of the pump field intensity and frequency, we find that there is a critical distance that changes the form of the spectrum. Above this distance, the four-wave mixing spectrum shows an ordinary three-peaked form and the effect of controlling its magnitude by changing the interparticle distance can be obtained. Below this critical distance, the four-wave mixing spectrum becomes single-peaked; and as the interparticle distance decreases, the spectrum is strongly suppressed. The behavior of the system is explained using the effective Rabi frequency that creates plasmonic metaresonances in the hybrid structure. In addition, the behavior of the effective Rabi frequency is explained via an analytical solution of the density matrix equations.

  20. Particle production of a graphite target system for the intensity frontier

    SciTech Connect (OSTI)

    Ding, X.; Kirk, H.; McDonald, K. T.

    2015-05-03

    A solid graphite target system is considered for an intense muon and/or neutrino source in support of physics at the intensity frontier. We previously optimized the geometric parameters of the beam and target to maximize particle production at low energies by incoming protons with kinetic energy of 6.75 GeV and an rms geometric emittance of 5 mm-mrad using the MARS15(2014) code. In this study, we ran MARS15 with ROOT-based geometry and also considered a mercury-jet target as an upgrade option. The optimization was extended to focused proton beams with transverse emittances from 5 to 50 mm-mrad, showing that the particle production decreases slowly with increasing emittance. We also studied beam-dump configurations to suppress the rate of undesirable high-energy secondary particles in the beam.