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1

Highly Effective Gene Transfection In Vivo by Alkylated Polyethylenimine  

E-Print Network (OSTI)

We mechanistically explored the effect of increased hydrophobicity of the polycation on the efficacy and specificity of gene delivery in mice. N-Alkylated linear PEIs with varying alkyl chain lengths and extent of substitution ...

Fortune, Jennifer A.

2

Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection  

SciTech Connect

The central theme of this dissertation is represented by the versatility of mesoporous silica nanomaterials in various applications such as catalysis and bio-applications, with main focus on biological applications of Mesoporous Silica Nanospheres (MSN). The metamorphosis that we impose to these materials from catalysis to sensing and to drug and gene delivery is detailed in this dissertation. First, we developed a synthetic method that can fine tune the amount of chemically accessible organic functional groups on the pores surface of MSN by exploiting electrostatic and size matching between the cationic alkylammonium head group of the cetyltrimethylammonium bromide (CTAB) surfactant and various anionic organoalkoxysilane precursors at the micelle-water interface in a base-catalyzed condensation reaction of silicate. Aiming nature imitation, we demonstrated the catalytic abilities of the MSNs, We utilized an ethylenediamine functional group for chelating Cu{sup 2+} as a catalytic functional group anchored inside the mesopores. Thus, a polyalkynylene-based conducting polymer (molecular wire) was synthesized within the Cu-functionalized MSNs silica catalyst. For sensing applications, we have synthesized a poly(lactic acid) coated mesoporous silica nanosphere (PLA-MSN) material that serves as a fluorescence sensor system for detection of amino-containing neurotransmitters in neutral aqueous buffer. We exploited the mesoporosity of MSNs for encapsulating pharmaceutical drugs. We examined bio-friendly capping molecules such as polyamidoamine dendrimers of generations G2 to G4, to prevent the drug leaching. Next, the drug delivery system employed MSNs loaded with Doxorubicin, an anticancer drug. The results demonstrated that these nano-Trojan horses have ability to deliver Doxorubicin to cancer cells and induce their death. Finally, to demonstrate the potential of MSN as an universal cellular transmembrane nanovehicle, we anchored positively charged dendrimers on the surface of MSN and utilize them to complex cationic DNA. The p-EGFP-CI gene-coated MSN nanocomposite was able to transfect cancer cell lines, such as human HeLa and CHO cancer cell lines. The gene carrier ability of MSNs was further proved by transfecting primary cells and cotransfecting of two different genes in cancer cell lines. In sum, MSN are versatile partners in several types of applications.

Daniela Rodica Radu

2005-12-19T23:59:59.000Z

3

Cationic phospholipids: structure?transfection activity relationships  

SciTech Connect

Synthetic cationic lipids are presently the most widely used non-viral gene carriers. Examined here is a particularly attractive cationic lipid class, triester phosphatidylcholines (PCs) exhibiting low toxicities and good transfection efficiency. Similarly to other cationic lipids, they form stable complexes (lipoplexes) with the polyanionic nucleic acids. A summary of studies on a set of {approx}30 cationic PCs reveals the existence of a strong, systematic dependence of their transfection efficiency on the lipid hydrocarbon chain structure: transfection activity increases with increase of chain unsaturation from 0 to 2 double bonds per lipid and decreases with increase of chain length in the range {approx}30-50 total number of chain carbon atoms. Maximum transfection was observed for ethyl phosphate PCs (EPCs) with monounsaturated 14:1 chains (total of 2 double bonds and 30 chain carbon atoms). Lipid phase behavior is known to depend strongly on the chain molecular structure and the above relationships thus substantiate a view that cationic PC phase propensities are an important determinant of their activity. Indeed, X-ray structural studies show that the rate of DNA release from lipoplexes as well as transfection activity well correlate with non-lamellar phase progressions observed in cationic PC mixtures with membrane lipids. These findings appear to be of considerable interest because, according to current views, key processes in lipid-mediated transfection such as lipoplex disassembly and DNA release within the cells are believed to take place upon cationic lipid mixing with cellular lipids.

Koynova, Rumiana; Tenchov, Boris; (NWU)

2010-01-18T23:59:59.000Z

4

Nano-biolistics: a method of biolistic transfection of cells and tissues using a gene gun with novel nanometer-sized projectiles  

E-Print Network (OSTI)

METHODOLOGY ARTICLE Open Access Nano-biolistics: a method of biolistic transfection of cells and tissues using a gene gun with novel nanometer-sized projectiles John A O’Brien1 and Sarah CR Lummis1,2* Abstract Background: Biolistic transfection... and nano-particles The core diameter of the particles used was 40 ± 0.8 nm or 991 ± 11 nm for the 40 nm (Alfa Aesar, MA, USA) and 1 ?m (Bio-Rad laboratories, USA) particles respec- tively. These particles have a hydrodynamic diameter of 47.2 ± 1.3 and 1060...

O'Brien, John A; Lummis, Sarah C R

2011-06-10T23:59:59.000Z

5

Polyelectrolyte-based Nanoparticles for Gene and Protein Delivery  

E-Print Network (OSTI)

were used to systematically inspect gene transfection efficiency and cytotoxicity. Transfection efficiency of non-degradable nanogels increased with increasing amounts of positive charge. Intriguingly, acid-labile nanogels bearing low charge showed...

Khondee, Supang

2011-05-31T23:59:59.000Z

6

Shotgun DNA microarrays and stage-specic gene expression in Plasmodium falciparum malaria  

E-Print Network (OSTI)

, labour intensive, and expensive to propagate. Second, the experimental power of transfection technology stages can be transfected, gene disruptions are only possible for non-essential genes, as this part there is no negative selection system. Transfection ef®- ciencies in P. falciparum are so poor that no gene function

7

Characterization of the Multidrug Resistance Protein Expressed in Cell Clones Stably Transfected with the Mouse mdr1 cDNA  

Science Journals Connector (OSTI)

...transfection of a biolog ically active cDNA presents distinct...out as described ("Materials and Methods"). The...positions of the anode and cathode are indicated . Arrow...second transcriptionally active member and have identified...third transcriptionally active mdr gene.1 The systematic...

Erwin Schurr; Martine Raymond; John C. Bell; and Philippe Gros

1989-05-15T23:59:59.000Z

8

Modulation of a membrane lipid lamellar?nonlamellar phase transition by cationic lipids: A measure for transfection efficiency  

SciTech Connect

Synthetic cationic lipids can be used as DNA carriers and are regarded to be the most promising non-viral gene carriers. For this investigation, six novel phosphatidylcholine (PC) cationic derivatives with various hydrophobic moieties were synthesized and their transfection efficiencies for human umbilical artery endothelial cells (HUAEC) were determined. Three compounds with relatively short, myristoleoyl or myristelaidoyl 14:1 chains exhibited very high activity, exceeding by {approx}10 times that of the reference cationic derivative dioleoyl ethylPC (EDOPC). Noteworthy, cationic lipids with 14:1 hydrocarbon chains have not been tested as DNA carriers in transfection assays previously. The other three lipids, which contained oleoyl 18:1 and longer chains, exhibited moderate to weak transfection activity. Transfection efficiency was found to correlate strongly with the effect of the cationic lipids on the lamellar-to-inverted hexagonal, L{sub {alpha}} {yields} H{sub II}, phase conversion in dipalmitoleoyl phosphatidylethanolamine dispersions (DPoPE). X-ray diffraction on binary DPoPE/cationic lipid mixtures showed that the superior transfection agents eliminated the direct L{sub {alpha}} {yields} H{sub II} phase transition and promoted formation of an inverted cubic phase between the L{sub {alpha}} and H{sub II} phases. In contrast, moderate and weak transfection agents retained the direct L{sub {alpha}} {yields} H{sub II} transition but shifted to higher temperatures than that of pure DPoPE, and induced cubic phase formation at a later stage. On the basis of current models of lipid membrane fusion, promotion of a cubic phase by the high-efficiency agents may be considered as an indication that their high transfection activity results from enhanced lipoplex fusion with cellular membranes. The distinct, well-expressed correlation established between transfection efficiency of a cationic lipid and the way it modulates nonlamellar phase formation of a membrane lipid could be useful as a criterion to assess the quality of lipid carriers and for rational design of new and superior nucleotide delivery agents.

Tenchov, Boris G.; Wang, Li; Koynova, Rumiana; MacDonald, Robert C. (NWU)

2010-01-18T23:59:59.000Z

9

Most Viewed Documents - Biology and Medicine | OSTI, US Dept of Energy,  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - Biology and Medicine Most Viewed Documents - Biology and Medicine Drug Retention Times Center for Human Reliability Studies (2007) External dose-rate conversion factors for calculation of dose to the public Not Available (1988) Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; et al. (2002) Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection Daniela Rodica Radu (2005) Tolerance doses for treatment planning Lyman, J.T. (1985) Preliminary Benchmarking Efforts and MCNP Simulation Results for Homeland Security Robert Hayes (2008) Function and dynamics of aptamers: A case study on the malachite green aptamer Wang, Tianjiao (2008) Extremophiles 2004 Frank Robb (2004) Elemental mercury removal using a wet scrubber.

10

April 2013 Most Viewed Documents for Chemistry | OSTI, US Dept of Energy,  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Chemistry April 2013 Most Viewed Documents for Chemistry Lithium literature review: lithium's properties and interactions Jeppson, D.W.; Ballif, J.L.; Yuan, W.W.; Chou, B.E. (1978) 123 Electrical conductivity measurements of aqueous electrolyte solutions at high temperatures and high pressures Ho, P.C.; Palmer, D.A. (1995) 102 Vapor-liquid equilibria for nitric acid-water and plutonium nitrate-nitric acid-water solutions Maimoni, A. (1980) 95 Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection Daniela Rodica Radu (2005) 84 Flammability characteristics of combustible gases and vapors. [249 refs] Zabetakis, M.G. (1964) 80 Molecular catalytic hydrogenation of aromatic hydrocarbons and hydrotreating of coal liquids. Yang, Shiyong; Stock, L.M. (1996)

11

April 2013 Most Viewed Documents for Biology And Medicine | OSTI, US Dept  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Biology And Medicine April 2013 Most Viewed Documents for Biology And Medicine Publications in biomedical and environmental sciences programs, 1981 Moody, J.B. (comp.) (1982) 306 Drug Retention Times Center for Human Reliability Studies (2007) 99 SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE GENERATOR SETS. KRISHNA,C.R. (1999) 95 Defining the Effectiveness of UV Lamps Installed in Circulating Air Ductwork Douglas VanOsdell; Karin Foarde (2002) 84 Mesoporous Silica Nanomaterials for Applications in Catalysis, Sensing, Drug Delivery and Gene Transfection Daniela Rodica Radu (2005) 84 Advisory Committee on human radiation experiments. Supplemental Volume 2a, Sources and documentation appendices. Final report NONE (1995) 72 Dose and volume specification for reporting interstitial therapy

12

Reduced expression of Autographa californica nucleopolyhedrovirus ORF34, an essential gene, enhances heterologous gene expression  

SciTech Connect

Autographa californica multiple nucleopolyhedrovirus ORF34 is part of a transcriptional unit that includes ORF32, encoding a viral fibroblast growth factor (FGF) and ORF33. We identified ORF34 as a candidate for deletion to improve protein expression in the baculovirus expression system based on enhanced reporter gene expression in an RNAi screen of virus genes. However, ORF34 was shown to be an essential gene. To explore ORF34 function, deletion (KO34) and rescue bacmids were constructed and characterized. Infection did not spread from primary KO34 transfected cells and supernatants from KO34 transfected cells could not infect fresh Sf21 cells whereas the supernatant from the rescue bacmids transfection could recover the infection. In addition, budded viruses were not observed in KO34 transfected cells by electron microscopy, nor were viral proteins detected from the transfection supernatants by western blots. These demonstrate that ORF34 is an essential gene with a possible role in infectious virus production.

Salem, Tamer Z. [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States) [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States); Department of Microbial Molecular Biology, AGERI, Agricultural Research Center, Giza 12619 (Egypt); Division of Biomedical Sciences, Zewail University, Zewail City of Science and Technology, Giza 12588 (Egypt); Zhang, Fengrui [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States)] [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States); Thiem, Suzanne M., E-mail: smthiem@msu.edu [Department of Entomology, Michigan State University, East Lansing, MI 48824 (United States); Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824 (United States)

2013-01-20T23:59:59.000Z

13

Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells  

Science Journals Connector (OSTI)

Recombinant adeno-associated virus (rAAV) has emerged in recent years as a promising gene therapy vector that may be used in the treatment of diverse human diseases. The major obstacle to broadening the usage of rAAV vectors remains the limited capacity of available production systems to provide sufficient rAAV quantities for preclinical and clinical trials. The impracticality of expanding commonly used adherent cell lines represents a limitation to large-scale production. This paper describes successful productions of rAAV type 2 using suspension-growing human embryonic kidney (HEK293) cells in serum-free medium. The developed process, based on triple transfection employing polyethylenimine (PEI) as DNA transporter, allowed for a serum-free production of AAV, yielding viral vector titer up to 4.5 × 1011 infectious viral particles (IVP) in a 3.5-L bioreactor. A maximum ratio of VG:IVP in the order of 200:1 was obtained, indicating the efficient encapsidation of viral vectors in HEK293 cells. The effect of varying the ratio of three plasmids and the influence of cell density at transfection were studied. The conditioned medium did not limit or inhibit the rAAV production; therefore, the elimination of the medium exchange step before or after transfection greatly simplified the scale-up of rAAV production. The cell-specific viral titers obtained in bioreactor suspension cultures were similar or higher than those obtained with control adherent cell cultures which further supported the scalability of the process. From multiple aspects including process simplicity, scalability, and low operating costs, this transfection method appears to be the most promising technology for large-scale production of rAAV.

Yves Durocher; Phuong Lan Pham; Gilles St-Laurent; Danielle Jacob; Brian Cass; Parminder Chahal; Cara J. Lau; Joséphine Nalbantoglu; Amine Kamen

2007-01-01T23:59:59.000Z

14

E-Print Network 3.0 - augment transfection efficiency Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

its transfection efficiency was highly dependent upon the presence... of nigericindan inhibitor of endosomal acidificationdwhich verified that the ... Source: Park, Jong-Sang -...

15

The investigation of controlled release microchips, nanoparticles, and sirna for gene therapy in tissue engineering applications  

E-Print Network (OSTI)

to a decrease in viability of the cells. It was also noted that the method of cell death is likely to be apoptosis. To confirm the efficacy of gene therapy through transfection, the transfection of the serum response factor (SRF) gene plasmid DNA...

Chern, Christina

2009-05-15T23:59:59.000Z

16

Degradable Terpolymers with Alkyl Side Chains Demonstrate Enhanced Gene Delivery Potency and Nanoparticle Stability  

E-Print Network (OSTI)

Degradable, cationic poly(?-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency ...

Eltoukhy, Ahmed A.

17

Non-Leaky Vesicle Fusion and Enhanced Cell Transfection Using a Cationic Facial Amphiphile  

E-Print Network (OSTI)

the interpreta- tion of results. In addition, there is the potential of discovering new types of fusion promotersNon-Leaky Vesicle Fusion and Enhanced Cell Transfection Using a Cationic Facial Amphiphile Yvonne R Dublin 2, Ireland ReceiVed December 23, 1999 Membrane fusion is an essential feature in many cellular

Smith, Bradley D.

18

Enhanced Transfection Efficiency and Reduced Cytotoxicity of Novel Lipid–Polymer Hybrid Nanoplexes  

Science Journals Connector (OSTI)

Enhanced Transfection Efficiency and Reduced Cytotoxicity of Novel Lipid–Polymer Hybrid Nanoplexes ... Authors are thankful to Indian National Science Academy (INSA), Government of India, New Delhi, for providing financial assistance and Department of Biotechnology (DBT) for providing fellowship to S.K. Authors are also thankful to Director, NIPER for providing necessary infrastructure facilities. ...

Sanyog Jain; Sandeep Kumar; Ashish Kumar Agrawal; Kaushik Thanki; Uttam Chand Banerjee

2013-04-18T23:59:59.000Z

19

July 2013 Most Viewed Documents for Renewable Energy Sources...  

Office of Scientific and Technical Information (OSTI)

2013 Most Viewed Documents for Renewable Energy Sources Science Subject Feed Chapter 11. Heat Exchangers Rafferty, Kevin D.; Culver, Gene (1998) 484 > Environmental Impacts of...

20

April 2013 Most Viewed Documents for Renewable Energy Sources...  

Office of Scientific and Technical Information (OSTI)

2013 Most Viewed Documents for Renewable Energy Sources Science Subject Feed Chapter 11. Heat Exchangers Rafferty, Kevin D.; Culver, Gene (1998) 1252 > Seventh Edition Fuel Cell...

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


21

Transfection of neurons in culture A.Ghosh, H. Dudek, M.E. Greenberg (1995)  

E-Print Network (OSTI)

transfection. Making CaCl2/DNA ppts: For 24-well plates: 500 µl media per well; 3 µg DNA in 30 µl ppt per well. Recipe to make 300 µl ppt (10 wells): 1. Make 150 µl DNA mix: 2.0 M CaCl2 15µl (bring CaCl2 to 37 C is too clumpy, try a lower concentration of CaCl2. If it doesn't form fast enough, try a higher

Ghosh, Anirvan

22

User_ViewRecords  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

User Records User Records © 2011 SuccessFactors, Inc. - 1 - SuccessFactors Learning Confidential. All rights reserved. Job Aid: Viewing User Records Purpose The purpose of this job aid is to guide users through the step-by-step process of viewing their records. Each task demonstrates viewing of different records. Task A. View To-Do List Enter the web address (URL) of the user application into your browser Address field and press the Enter key. Enter your user ID in the User ID textbox. Enter your password in the Password textbox. Click Sign In. View To-Do List (filter, view) 7 Steps Task A View Completed Work 8 Steps Task B View Curriculum Status and Details 11 Steps Task C 3 3 1 2 2 1 SuccessFactors Learning v 6.4 User Job Aid Viewing User Records

23

SGHTL-34, a thyrotrophin-responsive immortalised human thyroid cell line generated by transfection  

Science Journals Connector (OSTI)

Normal human thyrocytes were immortalised by electroporation-mediated transfection with the plasmid pSVSneo. One resultant cell line (SGHTL-34) contains approximately 10 copies of simian virus 40 (SV40) early region incorporated into the genome and has been in continuous monolayer culture for 9 months. SGHTL-34 cells grow rapidly (doubling time 30 h) and contain cytokeratin filaments. They demonstrate a morphological change in response to thyrotrophin (TSH) and possess a TSH- and forskolin-sensitive adenylate cyclase, the thresholds for stimulation being 10 ?U/ml bovine TSH and 10?7 M forskolin. The development of this novel human thyrocyte cell line may allow further study of the regulation of human thyroid growth and differentiation.

G.StJ. Whitley; S.S. Nussey; A.P. Johnstone

1987-01-01T23:59:59.000Z

24

Self-assembled pentablock copolymers for selective and sustained gene delivery  

SciTech Connect

The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

Zhang, Bingqi

2011-05-15T23:59:59.000Z

25

Views on Automation  

Science Journals Connector (OSTI)

Views on Automation ... Industrial managements, he feels, must allay workers' fears by showing how they can take pride in the greater accomplishment of automated plants. ...

1957-07-29T23:59:59.000Z

26

NEWS & VIEWS Glass dynamics  

E-Print Network (OSTI)

NEWS & VIEWS Glass dynamics Diverging views on glass transition Gregory B. mc.mckenna@ttu.edu T he glass transition is one of the most intriguing phenomena in the world of soft condensed matter. Despite decades of study, many aspects of the behaviour of glass-forming liquids remain elusive

Weeks, Eric R.

27

News and Views  

Science Journals Connector (OSTI)

......Model 8600 and 8700 gas chromatographs to...untended operation of the gas chromatograph under...0325) 311044. 133 News and Views Macintosh-compatible...speed of the Apple drives and a software incompatibility...for a corporate 134 News and Views licence...that Chem-X was the natural choice: 'Chem-X......

Alan H. Fielding

1990-04-01T23:59:59.000Z

28

Isolation and characterization of Agouti: a diabetes/obesity related gene  

DOE Patents (OSTI)

The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.

Woychik, Richard P. (Knoxville, TN)

2000-06-27T23:59:59.000Z

29

Isolation and characterization of Agouti: a diabetes/obesity related gene  

DOE Patents (OSTI)

The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.

Woychik, Richard P. (Knoxville, TN)

1998-01-01T23:59:59.000Z

30

Taking the long view  

NLE Websites -- All DOE Office Websites (Extended Search)

Taking the long view Taking the long view Taking the long view on environmental stewardship A newly articulated mission for environmental stewardship at the Laboratory can be summed up in a simple phrase: clean up the past, control current operations, and create a sustainable future. March 20, 2012 Los Alamos Aerial Aerial view of a canyon in Los Alamos, New Mexico. Contact Environmental Communication & Public Outreach P.O. Box 1663 MS M996 Los Alamos, NM 87545 (505) 667-0216 Email "The future viability of the Lab hinges on demonstrating to public that we protect human health and the environment." Environmental stewardship strategy looks 50 years into the future As a way of integrating environmental protection activities into a comprehensive strategy, Kevin Smith, manager of the U.S. Department of

31

Fluoride enhances transfection activity of carbonate apatite by increasing cytoplasmic stability of plasmid DNA  

SciTech Connect

Highlights: {yields} Cytoplasmic stability of plasmid DNA is enhanced by fluoride incorporation into carbonate apatite carrier. {yields} Fluoridated carbonate apatite promotes a robust increase in transgene expression. {yields} Controlled dissolution of fluoridated carbonate apatite in endosomal acidic environment might buffer the endosomes and prevent degradation of the released DNA. -- Abstract: Intracellular delivery of a functional gene or a nucleic acid sequence to specifically knockdown a harmful gene is a potential approach to precisely treat a critical human disease. The intensive efforts in the last few decades led to the development of a number of viral and non-viral synthetic vectors. However, an ideal delivery tool in terms of the safety and efficacy has yet to be established. Recently, we have developed pH-sensing inorganic nanocrystals of carbonate apatite for efficient and cell-targeted delivery of gene and gene-silencing RNA. Here we show that addition of very low level of fluoride to the particle-forming medium facilitates a robust increase in transgene expression following post-incubation of the particles with HeLa cells. Confocal microscopic observation and Southern blotting prove the cytoplasmic existence of plasmid DNA delivered by likely formed fluoridated carbonate apatite particles while degradation of plasmid DNA presumably by cytoplasmic nucleases was noticed following delivery with apatite particles alone. The beneficial role of fluoride in enhancing carbonate apatite-mediated gene expression might be due to the buffering potential of generated fluoridated apatite in endosomal acidic environment, thereby increasing the half-life of delivered plasmid DNA.

Chowdhury, E.H., E-mail: md.ezharul.hoque@med.monash.edu.my [Jeffrey Cheah School of Medicine and Health Sciences, Monash University Sunway Campus, Jalan Lagoon Selatan, Bandar Sunway, Selangor Darul Ehsan (Malaysia)

2011-06-17T23:59:59.000Z

32

Prarie View RDF  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

PRAIRIE VIEW RDF PRAIRIE VIEW RDF 2 Prairie View RDF  Located at JAAP (approx. 40 miles southwest of Chicago), 223 acres on 455 Acre Parcel  Will County Owner; Waste Management, Operator  Maximum 23-Year Life WM/Will County Methane to Energy Plant  Landfill Contract Signed w/WM in 1997 w/Gas-to- Energy Plant Clause  County Retains Gas Rights &WM Installs Gas Collection System  WM owns Methane to Energy Plant &Tax Credits 3 CONTRACT PHASE  DOE Grant Applied 6/09  County Board Approves DOE EECBG Strategy 11/09  1 Million DOE Funds to Methane to Energy Plant  Schiff Harden Hired to Negotiate Gas to Energy Contract  February 2010 County Board Authorizes Contract Execution 4 5 METHANE TO ENERGY PLANT DETAILS  Waste Management Required To

33

View dependent fluid dynamics  

E-Print Network (OSTI)

VIEW DEPENDENT FLUID DYNAMICS A Thesis by BRIAN ARTHUR BARRAN Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE May 2006 Major Subject: Visualization... Sciences VIEW DEPENDENT FLUID DYNAMICS A Thesis by BRIAN ARTHUR BARRAN Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved by: Chair of Committee, Donald...

Barran, Brian Arthur

2006-08-16T23:59:59.000Z

34

News and Views  

Science Journals Connector (OSTI)

... -16. The discussions on road lighting, from the point of view both of the pedestrian and the car driver, were valuable, as they show how complex the problem is ... problem is, depending as it does on difficult questions of physiology and psychology. The pedestrian wants to see small obstructions on the road and the numbers on the houses; ...

1928-07-28T23:59:59.000Z

35

ParaView at NERSC  

NLE Websites -- All DOE Office Websites (Extended Search)

ParaView ParaView ParaView Introduction ParaView is an open-source, multi-platform data analysis and visualization application. ParaView users can quickly build visualizations to analyze their data using qualitative and quantitative techniques. The data exploration can be done interactively in 3D or programmatically using ParaView's batch processing capabilities. ParaView was developed to analyze extremely large datasets using distributed memory computing resources. It can be run on supercomputers to analyze datasets of terascale as well as on laptops for smaller data. Remote Visualization with ParaView ParaView is a client-server application. The ParaView client (or simply paraview) will run on your desktop while the server will run at the remote supercomputing site. The following describes the steps you will take to

36

Stereoscopic optical viewing system  

DOE Patents (OSTI)

An improved optical system which provides the operator with a stereoscopic viewing field and depth of vision, particularly suitable for use in various machines such as electron or laser beam welding and drilling machines. The system features two separate but independently controlled optical viewing assemblies from the eyepiece to a spot directly above the working surface. Each optical assembly comprises a combination of eye pieces, turning prisms, telephoto lenses for providing magnification, achromatic imaging relay lenses and final stage pentagonal turning prisms. Adjustment for variations in distance from the turning prisms to the workpiece, necessitated by varying part sizes and configurations and by the operator's visual accuity, is provided separately for each optical assembly by means of separate manual controls at the operator console or within easy reach of the operator.

Tallman, C.S.

1986-05-02T23:59:59.000Z

37

Nucleotide sequences required for the regulation of a rat alpha 2u-globulin gene by glucocorticoids.  

Science Journals Connector (OSTI)

...earlier experiments we showed that transfected c2u-globulin genes were expressed and regulated...accumulate four times the wild-type level of c2u-globulin mRNA in response to dexamethasone...required for the initiation and maintenance of c2u-globulin expression. These results suggest...

W R Addison; D T Kurtz

1986-07-01T23:59:59.000Z

38

The View from HQ  

National Nuclear Security Administration (NNSA)

A publication of the Office of Advanced Simulation & Computing, NNSA Defense Programs A publication of the Office of Advanced Simulation & Computing, NNSA Defense Programs NA-ASC-500-07-Issue 3 May 2007 The View from HQ by Dimitri Kusnezov I have been spending much of my time these days thinking about science, technology and engineering and the role of the laboratories and how that will be reflected in the Complex of the future. This is on my mind for two reasons: one is my responsibility to

39

NUPlans Budgeting Grant Input View  

E-Print Network (OSTI)

NUPlans Budgeting Grant Input View FMS704 NUPlansGrantInputViewV2 Last updated 4/7/2014 - rb © 2014 Northwestern University FMS704 NUPlans Contributor Budgeting 1 of 5 NUPlans Grant Input View NUPlans enables schools and units with grant projects to input grant expense estimates per project for the next fiscal

Shull, Kenneth R.

40

Protective laser beam viewing device  

DOE Patents (OSTI)

A protective laser beam viewing system or device including a camera selectively sensitive to laser light wavelengths and a viewing screen receiving images from the laser sensitive camera. According to a preferred embodiment of the invention, the camera is worn on the head of the user or incorporated into a goggle-type viewing display so that it is always aimed at the area of viewing interest to the user and the viewing screen is incorporated into a video display worn as goggles over the eyes of the user.

Neil, George R.; Jordan, Kevin Carl

2012-12-18T23:59:59.000Z

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


41

Recent developments with the human repair genes ERCC2, ERCC4, and XRCC1  

SciTech Connect

ERCC2 was first identified as a gene on human chromosome 19 that complemented the UV sensitivity of CHO UV5 cells in somatic cell hybrids. Subsequent studies localized ERCC2 to the same chromosomal region (19q13.2--13.3) as the ERCC1 gene and showed that the two genes were less than 250 kb apart. Cloning of ERCC2 was accomplished by transfection of genomic DNA into UV5 cells and rescue of the gene from a secondary transformant. Recovery of the gene was aided by the presence of repetitive sequences that were detected on Southern blots with a probe for Alu-family repeats. ERCC2, which is 19 kb in size, quantitatively corrected the UV sensitivity and incision defect in UV5 cells upon transfection. An ERCC2 CDNA clone was recovered from the pcD2 expression library. Although this clone was truncated at the 5 in. end, it conferred transient, but not stable, correction to UV5 cells upon transfection. Based on genomic sequence, this clone was extended by oligonucleotide addition to obtain minigene constructs in which the complete open reading frame (ORF) was present. Translation of the ERCC2 ORF gives an amino acid sequence that has 72% similarity with the S. cerevisiae RAD3 protein, which encodes a DNA helicase.

Thompson, L.H.; Caldecott, K.W.; Brookman, K.W.; Weber, C.A.; Salazar, E.S.; Takayama, K. [Lawrence Livermore National Lab., CA (United States); Fornace, A.J. [National Cancer Inst., Bethesda, MD (United States). Lab. of Molecular Pharmacology

1992-11-06T23:59:59.000Z

42

The View from HQ  

National Nuclear Security Administration (NNSA)

  NA-ASC-500-07 Issue 2 January 2007 The View from HQ Sitting in airports and planes is risky beyond the obvious dangers now in the news. Uninter- rupted time to think may lead to new ideas. Instinct instructs us that when we hear Wash- ington has some new ideas, the result must be bad. After all, ideas suggest change, which is inherently disruptive. Today the notion of predictivity is on my mind as I am leaving the V&V 2007 meeting in Los Alamos. Predictivity is on my short list of overused, ill-defined words. Washington main- tains a full lexicon of such words-a fair number of which find their way into common usage.

43

False color viewing device  

DOE Patents (OSTI)

This invention consists of a viewing device for observing objects in near-infrared false-color comprising a pair of goggles with one or more filters in the apertures, and pads that engage the face for blocking stray light from the sides so that all light reaching, the user`s eyes come through the filters. The filters attenuate most visible light and pass near-infrared (having wavelengths longer than approximately 700 nm) and a small amount of blue-green and blue-violet (having wavelengths in the 500 to 520 nm and shorter than 435 nm, respectively). The goggles are useful for looking at vegetation to identify different species and for determining the health of the vegetation, and to detect some forms of camouflage.

Kronberg, J.W.

1991-05-08T23:59:59.000Z

44

Cationic Lipid-Nucleic Acid Complexes for Gene Delivery And Silencing: Pathways And Mechanisms for Plasmid Dna And Sirna  

SciTech Connect

Motivated by the promises of gene therapy, there is great interest in developing non-viral lipid-based vectors for therapeutic applications due to their low immunogenicity, low toxicity, ease of production, and the potential of transferring large pieces of DNA into cells. In fact, cationic liposome (CL) based vectors are among the prevalent synthetic carriers of nucleic acids (NAs) currently used in gene therapy clinical trials worldwide. These vectors are studied both for gene delivery with CL-DNA complexes and gene silencing with CL-siRNA (short interfering RNA) complexes. However, their transfection efficiencies and silencing efficiencies remain low compared to those of engineered viral vectors. This reflects the currently poor understanding of transfection-related mechanisms at the molecular and self-assembled levels, including a lack of knowledge about interactions between membranes and double stranded NAs and between CL-NA complexes and cellular components. In this review we describe our recent efforts to improve the mechanistic understanding of transfection by CL-NA complexes, which will help to design optimal lipid-based carriers of DNA and siRNA for therapeutic gene delivery and gene silencing.

Ewert, K.K.; Zidovska, A.; Ahmad, A.; Bouxsein, N.F.; Evans, H.M.; McAllister, C.S.; Samuel, C.E.; Safinya, C.R.; /SLAC

2012-07-17T23:59:59.000Z

45

Comparison of gene expression in pre-implantation bovine embryos either injected or transfected with a siRNA targeted against E-cadherin  

E-Print Network (OSTI)

be microinjected with plasmid DNA or small interfering RNA (siRNA). Given the cost and skill associated with both methods, a preliminary investigation exploring alternative delivery techniques of siRNA (transient expression) into bovine zygotes with a nonhomologous...

Hanna, Carol Bailey McCormick

2009-05-15T23:59:59.000Z

46

Chisolm View | Open Energy Information  

Open Energy Info (EERE)

Chisolm View Chisolm View Jump to: navigation, search Name Chisolm View Facility Chisolm View Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner GE Energy Financial Service / Enel Green Power North America Developer TradeWind Energy Energy Purchaser Alabama Power Company Location Hunter OK Coordinates 36.59527057°, -97.54501104° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":36.59527057,"lon":-97.54501104,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

47

Printed 3D Multi-View Images  

Science Journals Connector (OSTI)

The technique to produce full-parallax 3D multi-view still pictures is described. The matrix of source views (from 6x6 to 15x15 views) is built from computer-generated images or...

Kim, Sung-Sik; Son, Kwang-Hun; Saveljev, V V; Son, Jung-Young

2001-01-01T23:59:59.000Z

48

List View | Data.gov  

NLE Websites -- All DOE Office Websites (Extended Search)

List View List View Safety Data/Tools Apps Challenges Resources Blogs Let's Talk Safety You are here Data.gov » Communities » Safety List View Interactive applications that visually display large datasets provide a portal to explore data and make discoveries. Federal agencies collect information on energy production, use, natural resources, and energy infrastructure logistics and this data can be used to create calculators, interactive maps, and other applications that leverage this data. These applications provide user communities the ability to highlight the energy issues that are occurring within their communities, aid businesses plan and analyze their proposed projects, and provide a baseline for analyzing how energy resources can be most optimally and efficiently used. This page

49

Wide field of view telescope  

DOE Patents (OSTI)

A wide field of view telescope having two concave and two convex reflective surfaces, each with an aspheric surface contour, has a flat focal plane array. Each of the primary, secondary, tertiary, and quaternary reflective surfaces are rotationally symmetric about the optical axis. The combination of the reflective surfaces results in a wide field of view in the range of approximately 3.8.degree. to approximately 6.5.degree.. The length of the telescope along the optical axis is approximately equal to or less than the diameter of the largest of the reflective surfaces.

Ackermann, Mark R. (Albuquerque, NM); McGraw, John T. (Placitas, NM); Zimmer, Peter C. (Albuquerque, NM)

2008-01-15T23:59:59.000Z

50

Limited View Angle Iterative CT Reconstruction  

E-Print Network (OSTI)

;Some Prior Literature in Limited View Tomography CT with limited-angle data and few views IRR algorithm Iterative Reconstruction-Reprojection (IRR) : An Algorithm for Limited Data Cardiac- Computed-views and limited-angle data in divergent-beam CT by E. Y. Sidky, CM Kao, and X. Pan (2006) Few-View Projection

51

Census and viewing of organisms  

NLE Websites -- All DOE Office Websites (Extended Search)

Census and viewing of organisms Census and viewing of organisms Name: m hariaczyi Status: N/A Age: N/A Location: N/A Country: N/A Date: Around 1993 Question: How many organisms exist in the world today? What is the most powerful microscope that could be used for viewing organism? Replies: The most powerful microscope is called an electron microscope, which can be used for viewing entire organisms, although few organisms are small enough to see all of them at high magnifications allowed by this microscope. So most often its used to look at fixed sections of organisms. Since the electron microscope only works in a vacuum, with no air, you cannot look at live organisms. To do that, probably the most powerful microscope is called a Nomarski, or in technical terms, a "differential interference contrast" microscope. This is a modification of a normal light microscope that allows better contrast in living tissue. It is not any more powerful than a light microscope, and is much less powerful than an electron microscope, but it allows you to see living things much better.

52

GoddardView Welcome Home!  

E-Print Network (OSTI)

GoddardView Welcome Home! Pg 2 - 3 History's Greatest Comet Hunter Pg 8 Employee Spotlight: Ernest Program Ends Amid Kudos - 6 Engineers Organize With A Desire To Inspire - 7 History's Greatest Comet on the runway at Edwards Air Force Base, California, after a safe landing August 9, 2005. Photo Credit: NASA 02

Christian, Eric

53

View  

Science Journals Connector (OSTI)

Mn, the concentration gradient that drives the diffusion is maintained by the precipitation of insoluble oxides. In the case of Cd, ... Cientifica e Tecnologica (

2000-10-07T23:59:59.000Z

54

View  

E-Print Network (OSTI)

May 18, 2012 ... bottleneck, long-time production simulations will be severely hampered ...... t ¼ 0.975, (g) t ¼ 1.0, (h) t ¼ 1.025, (i) t ¼ 1.275, (j) t ¼ 1.525, (k) t ¼ ...

S. Dong

2012-06-21T23:59:59.000Z

55

View  

E-Print Network (OSTI)

In order to increase the search capability of MBH, a population framework has been proposed ... The key idea is to avoid new individuals to enter the population if someone similar (in a ..... We measure the efficiency in terms of number of (two-.

andrea,,,

56

View  

E-Print Network (OSTI)

May 31, 2005 ... Robert M. Freund: MIT Sloan School of Management, 50 Memorial Drive, Cambridge, Massachusetts 02139-4307, ...... the transition kernel.

2005-05-30T23:59:59.000Z

57

View  

Science Journals Connector (OSTI)

89-l 1268) ran the carbon analysis of the sediment trap material ..... vehicle camera system were analyzed with a ... tribution of distances with the computer pro-.

1999-12-21T23:59:59.000Z

58

View  

E-Print Network (OSTI)

obtained by using different uncertainty sets estimated using simulated and ... Given a fixed mix of electric power plants (nuclear, thermal, hydroelectric, and ...

2011-01-28T23:59:59.000Z

59

View  

E-Print Network (OSTI)

Aug 19, 2009 ... linear-algebraic and graph theoretic properties of this matrix class. The con- ..... The MatLab solvers linprog and quadprog were used.

2010-03-14T23:59:59.000Z

60

View  

E-Print Network (OSTI)

Mar 14, 2006 ... ... of the paper is devoted to the development of background material for ..... Note that the optimization problem in the correction phase is solved over ...... In Phase I

2006-03-31T23:59:59.000Z

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


61

View  

E-Print Network (OSTI)

Mar 1, 2007 ... 2The logarithmic barrier for the half space {u ? Rn | a · u ? b} is ..... in the Uncapacitated Falicity Location Library (UflLib) [Hoe06]. .... For our test we use 36 unsolved UFL instances that come from two public sets of instances.

2007-03-01T23:59:59.000Z

62

View  

E-Print Network (OSTI)

cT w tj (cj z) + o (1) = wti (z) + o (1), since c-Ow(cz) = w(z) for any w E W and c > 0. We have obtained a contradiction with (2.29), which proves (2.28). If w t = w(' ...

2004-12-25T23:59:59.000Z

63

View  

Science Journals Connector (OSTI)

Apr 15, 1976 ... terms of Hairston's hypothesis, to find that only the ... be a component of the search by grazers .... to stop searching and to enter into a state.

2000-01-05T23:59:59.000Z

64

View  

E-Print Network (OSTI)

which has a 0 infimum, but does not attain it. Here the certificates of the bad behavior of the system in (3.32) are. Z = (. 1 0. 0 0. ) , V = (. 0 1. 1 0. ) . Example 2.

2014-05-14T23:59:59.000Z

65

View  

E-Print Network (OSTI)

1. Introduction. The purpose of the present paper is to develop some new directions of investigation in ..... For each i = 1, ..., m, and g = (x1, ..., xr,mr ), we have.

2003-09-25T23:59:59.000Z

66

View  

E-Print Network (OSTI)

Definition 1 The persistency of a variable xi is defined to be the probability that xi = 1 in the ..... i , we know a limited set of marginal moments mr i . We let ? ...

2005-04-19T23:59:59.000Z

67

View  

E-Print Network (OSTI)

In [4], Devinatz, Hopkins, and Smith proved the nilpotence theorem, a remark- able result which provides algebraic means for detecting nilpotence in the ...

1997-12-15T23:59:59.000Z

68

View  

Science Journals Connector (OSTI)

carbon (C) and increased mixing energies, making CO, limitation less likely. .... Verde Reef (Vera Cruz, Mexico). ..... solar energy is more important in deter-.

2000-03-03T23:59:59.000Z

69

View  

E-Print Network (OSTI)

Sep 3, 2003 ... Superconductors are able to carry equilibrium currents without resistance. .... by an Ohm's law where ? is the electric conductivity and b1 is a ...

1910-31-00T23:59:59.000Z

70

Viewed  

Science Journals Connector (OSTI)

Oct 27, 1982 ... study area does not contain indigenous io- .... Zn Handbook ofgeochemistry. V. 7, part 4. Spring ... Lakes-physics, chemistry, geology. Springer.

2000-02-09T23:59:59.000Z

71

View  

Science Journals Connector (OSTI)

This lake is in the Kigezi Highlands, western Uganda, in a narrow steep-sided branching river valley about 20 km long that has been dammed and drowned by a.

Orcas

72

View  

Science Journals Connector (OSTI)

1943. Treatment of experimental data. Wiley,. New York, N.Y. 344 p. ZIIIN-ELDIN, Z. P. 1961. Plankton pigments in. East Lagoon, Galveston, Texas. Trans. Am.

Orcas

73

View  

E-Print Network (OSTI)

GLEV train, a new bullet train under development in Japan, is formulated as the ... conservation law and v ? c represents a constraint on the maximum capacity at each ... Railways Technical Research Institute, Kokubunji, Tokyo 185-8540 Japan ... optimization since 1984 when Karmarkar proposed the projective scaling ...

2002-10-31T23:59:59.000Z

74

View  

E-Print Network (OSTI)

the random consequences of the chosen action, h(x, ?), are preferred to those of a baseline random variable Z for all utility ...... Ground truth. Envelope. Figure 3: ...

2012-06-29T23:59:59.000Z

75

View  

E-Print Network (OSTI)

A major challenge in using optimization to make risk-averse decisions in the face of uncertainty is how to specify an acceptable level of risk. Recently, Dentcheva ...

2011-06-22T23:59:59.000Z

76

View  

E-Print Network (OSTI)

maximum acceptable risk that one is willing to take. ... of initial wealth allocated to the assets, CVaR?(?T x) measures the risk of a given allocation x, b. 1 ...

2009-03-26T23:59:59.000Z

77

View  

E-Print Network (OSTI)

acceptable level of risk. As shown in [2], Problem (3) is a difficult, in fact NP-hard, combinatorial problem. Following [17] and [21], we choose to tackle it by ...

2010-02-08T23:59:59.000Z

78

View  

E-Print Network (OSTI)

allowed to be violated an “acceptable” amount of time. There are no ... optimal investment strategies with a certain level of risk [10]. Up to this point most research ...

2008-05-24T23:59:59.000Z

79

View  

E-Print Network (OSTI)

in the primal problem. As it can be seen by the number of floating point operations needed to generate the approximation to the set of efficient points, the strategy.

80

View  

E-Print Network (OSTI)

Oct 29, 2008 ... serial machine in floating point is well below our needs. 3 Notation. We are given an m × d design matrix P of floating point numbers and an.

2008-10-28T23:59:59.000Z

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


81

View  

E-Print Network (OSTI)

function, and the nuclear norm. The support function is based on the graph of the product of a matrix with its transpose. Closed form expressions for the support ...

2014-08-28T23:59:59.000Z

82

View  

E-Print Network (OSTI)

the results of [8] to obtain, for each natural number n, a simple nuclear C?- algebra An whose ordered K0-group is order isomorphic to Zn. This result was further ...

2008-02-01T23:59:59.000Z

83

View  

E-Print Network (OSTI)

the UCT and reproves Huaxin Lin's theorem on the classification of nuclear tracially AF ... A deep conjecture of Elliott asserts that the simple separable nuclear ...

2004-06-29T23:59:59.000Z

84

View  

E-Print Network (OSTI)

Q we have yi = Gdi and the G–orthogonality condition of vectors si, si+1 can be written as ?isT i Gsi+1 = yT i si+1 = 0 (we assume that ?i = 0). This together with ...

2009-03-10T23:59:59.000Z

85

View  

E-Print Network (OSTI)

job Ji is a function of its completion time, usually denoted by Ci. ..... For any t > max(P, d), there exists a value ? > 0 and a job index i? ? {1,...,n} such that, for any ...

2006-03-29T23:59:59.000Z

86

View  

E-Print Network (OSTI)

Feb 28, 2006 ... Abstract. The major focus of this work is to compare several methods for computing the proximal point of a nonconvex function via numerical ...

2006-02-28T23:59:59.000Z

87

View  

E-Print Network (OSTI)

Our original motivating application is in Electronics and arises in the development of pulse ...... In 8th International Symposium on Fundamentals of Computa-.

Christoph Buchheim,,,

88

View  

E-Print Network (OSTI)

Feb 28, 2012 ... and P. Dorta-González. Departamento de Métodos Cuantitativos en Econom?a y Gestión. Universidad de Las Palmas de Gran Canaria (Spain).

2012-02-28T23:59:59.000Z

89

Elucidation of the Mechanism of Gene Silencing using Small Interferin RNA: DNA Hybrid Molecules  

SciTech Connect

The recent discovery that short hybrid RNA:DNA molecules (siHybrids) induce long-term silencing of gene expression in mammalian cells conflicts with the currently hypothesized mechanisms explaining the action of small, interfering RNA (siRNA). As a first step to elucidating the mechanism for this effect, we set out to quantify the delivery of siHybrids and determine their cellular localization in mammalian cells. We then tracked the segregation of the siHybrids into daughter cells after cell division. Markers for siHybrid delivery were shown to enter cells with and without the use of a transfection agent. Furthermore, delivery without transfection agent only occurred after a delay of 2-4 hours, suggesting a degradation process occurring in the cell culture media. Therefore, we studied the effects of nucleases and backbone modifications on the stability of siHybrids under cell culture conditions.

Dugan, L

2006-02-08T23:59:59.000Z

90

September 2013 Most Viewed Documents for Renewable Energy Sources | OSTI,  

Office of Scientific and Technical Information (OSTI)

September 2013 Most Viewed Documents for Renewable Energy Sources September 2013 Most Viewed Documents for Renewable Energy Sources Chapter 11. Heat Exchangers Rafferty, Kevin D.; Culver, Gene (1998) 362 Wet cooling towers: rule-of-thumb design and simulation Leeper, S.A. (1981) 103 Chapter 17. Engineering cost analysis Higbee, Charles V. (1998) 79 Advanced Electric Submersible Pump Design Tool for Geothermal Applications Xuele Qi; Norman Turnquist; Farshad Ghasripoor (2012) 79 A study of lead-acid battery efficiency near top-of-charge and the impact on PV system design Stevens, J.W.; Corey, G.P. (1996) 76 PROPERTIES AND PERFORMANCE OF CEMENT-BASED GROUTS FOR GEOTHERMAL HEAT PUMP APPLICATIONS. ALLAN,M.L. (1999) 70 Solar radiation data manual for flat-plate and concentrating collectors Dunlap, M.A. [ed.]; Marion, W.; Wilcox, S. (null)

91

Glucose Regulates the Expression of the Apolipoprotein A5 Gene  

SciTech Connect

The apolipoprotein A5 gene (APOA5) is a key player in determining triglyceride concentrations in humans and mice. Since diabetes is often associated with hypertriglyceridemia, this study explores whether APOA5 gene expression is regulated by alteration in glucose homeostasis and the related pathways. D-glucose activates APOA5 gene expression in a time- and dose-dependent manner in hepatocytes, and the glycolytic pathway involved was determined using D-glucose analogs and metabolites. Together, transient transfections, electrophoretic mobility shift assays and chromatin immunoprecipitation assays show that this regulation occurs at the transcriptional level through an increase of USF1/2 binding to an E-box in the APOA5 promoter. We show that this phenomenon is not due to an increase of mRNA or protein expression levels of USF. Using protein phosphatases 1 and 2A inhibitor, we demonstrate that D-glucose regulates APOA5 gene via a dephosphorylation mechanism, thereby resulting in an enhanced USF1/2-promoter binding. Last, subsequent suppressions of USF1/2 and phosphatases mRNA through siRNA gene silencing abolished the regulation. We demonstrate that APOA5 gene is up regulated by D-glucose and USF through phosphatase activation. These findings may provide a new cross talk between glucose and lipid metabolism.

Fruchart, Jamila; Nowak, Maxime; Helleboid-Chapman, Audrey; Jakel, Heidelinde; Moitrot, Emmanuelle; Rommens, Corinne; Pennacchio, Len A.; Fruchart-Najib, Jamila; Fruchart, Jean-Charles

2008-04-07T23:59:59.000Z

92

Better Buildings Network View | November 2014  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network.

93

Better Buildings Network View | October 2014  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network.

94

Better Buildings Network View | September 2014  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network.

95

Better Buildings Network View | January 2015  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network.

96

Better Buildings Network View | December 2014  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network.

97

The Better Buildings Neighborhood View- Fall 2011  

Energy.gov (U.S. Department of Energy (DOE))

Better Buildings Neighborhood View, from the Better Buildings Neighborhood Program of the U.S. Department of Energy.

98

Better Buildings Network View | February 2014  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network.

99

California's Energy Future - The View to 2050  

E-Print Network (OSTI)

Energy Future - The View to 2050 Bin Biofuel Technology Hydrogen Ethanol from sugar and starch (e.g. , corn,

2011-01-01T23:59:59.000Z

100

The Better Buildings Neighborhood View- July 2012  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Neighborhood View monthly newsletter from the U.S. Department of Energy's Better Buildings Neighborhood Program.

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


101

Better Buildings Network View | April 2014  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network.

102

Better Buildings Network View | May 2014  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network.

103

Better Buildings Network View | March 2014  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network.

104

Better Buildings Network View | June 2014  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network.

105

Gene Frequency  

NLE Websites -- All DOE Office Websites (Extended Search)

Gene Frequency Gene Frequency Name: donna Location: N/A Country: N/A Date: N/A Question: If six fingers is a dominant human trait why do we have only five? Replies: This is simple. There are just not many genes in the human population for six fingers. Steve Sample Look in any high school biology book for what is known as Hardy-Weinberg equilibrium. These two scientists (separately) said that gene frequencies do not change much unless something in the environment selects them over other genes. In other words, unless 6 fingers somehow becomes an advantage, and five-fingered people have less of an advantage, the frequency of six fingered people in the population will not necessarily increase. This is the same reason that recessive traits don't disappear from the population. Also, six fingers is not considered attractive and they may not get as many mates. Also, more people are born with six fingers than you might imagine but just have them amputated shortly after birth.

106

Street Light View: Enriching Navigable Panoramic Street View Maps with Informative Illumination Thumbnails  

E-Print Network (OSTI)

1 Street Light View: Enriching Navigable Panoramic Street View Maps with Informative Illumination, Stony Brook University ABSTRACT Google Street View is a technology featured in Google Maps and Google Earth that provides panoramic and immersive views of street scenes in many cities around the world

Mueller, Klaus

107

Delivery of cationic polymer-siRNA nanoparticles for gene therapies in neural regeneration  

SciTech Connect

Highlights: Black-Right-Pointing-Pointer Nogo receptor can inhibit growth of injured axons, thus affecting neural regeneration. Black-Right-Pointing-Pointer The delivery of siRNA is crucial to inhibit NgR expression in NSCs. Black-Right-Pointing-Pointer Non-viral vector PEG-PEI condensed siRNA targeting NgR into nanoscale particles. Black-Right-Pointing-Pointer PEG-PEI/siRNA at N/P = 15 displayed high transfection efficiency and low cytotoxicity. Black-Right-Pointing-Pointer PEG-PEI has great potential in carrying siRNA to diminish the gene expression in NSCs. -- Abstract: The therapeutic applications of neural stem cells (NSCs) have potential to promote recovery in many obstinate diseases in central nervous system. Regulation of certain gene expressions using siRNA may have significant influence on the fate of NSC. To achieve the optimum gene silencing effect of siRNA, non-viral vector polyethylene glycol-polyethyleneimine (PEG-PEI) was investigated in the delivery of siRNA to NSCs. The characteristics of PEG-PEI/siRNA polyplexes were detected by scanning electron microscopy (SEM). The effects of nanoparticles on cell viability were measured via CCK-8 assay. In addition, the transfection efficiency was evaluated by fluorescence microscope and flow cytometry, and real-time PCR and Western Blot were employed to detect the gene inhibition effect of siRNA delivered by PEG-PEI. The SEM micrographs showed that PEG-PEI could condense siRNA to form diffuse and spherical nanoparticles. The cytotoxicity of PEG-PEI/siRNA nanocomplexes (N/P = 15) was significantly lower when compared with that of Lipofectamine 2000/siRNA (P < 0.05). Moreover, the highest transfection efficiency of PEG-PEI/siRNA nanoparticles was obtained at an N/P ratio of 15, which was better than that achieved in the transfection using Lipofectamine 2000 (P < 0.05). Finally, the gene knockdown effect of PEG-PEI/siRNA nanoparticles was verified at the levels of mRNA and protein. These results suggest that PEG-PEI may potentially be used as a siRNA delivery vector for neural regeneration therapy.

Liang, Yanran [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China); Liu, Zhonglin, E-mail: zhonglinliu@126.com [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China); Shuai, Xintao; Wang, Weiwei [School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China (China)] [School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, People's Republic of China (China); Liu, Jun [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China); Bi, Wei [Department of Neurology, The First Affiliated Hospital of Jinan University, No. 613, West Huangpu Road, Guangzhou 510630, People's Republic of China (China)] [Department of Neurology, The First Affiliated Hospital of Jinan University, No. 613, West Huangpu Road, Guangzhou 510630, People's Republic of China (China); Wang, Chuanming; Jing, Xiuna; Liu, Yunyun [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China); Tao, Enxiang, E-mail: taoenxiang@yahoo.com.cn [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)] [Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, No. 107, West Yanjiang Road, Guangzhou 510120, People's Republic of China (China)

2012-05-18T23:59:59.000Z

108

TotalView Parallel Debugger at NERSC  

NLE Websites -- All DOE Office Websites (Extended Search)

Totalview Totalview Totalview Description TotalView from Rogue Wave Software is a parallel debugging tool that can be run with up to 512 processors. It provides both X Windows-based Graphical User Interface (GUI) and command line interface (CLI) environments for debugging. The performance of the GUI can be greatly improved if used in conjunction with free NX software. The TotalView documentation web page is a good resource for learning more about some of the advanced TotalView features. Accessing Totalview at NERSC To use TotalView at NERSC, first load the TotalView modulefile to set the correct environment settings with the following command: % module load totalview Compiling Code to Run with TotalView In order to use TotalView, code must be compiled with the -g option. We

109

Mining Virulence Genes Using Metagenomics  

E-Print Network (OSTI)

When a bacterial genome is compared to the metagenome of an environment it inhabits, most genes recruit at high sequence identity. In free-living bacteria (for instance marine bacteria compared against the ocean metagenome) certain genomic regions are totally absent in recruitment plots, representing therefore genes unique to individual bacterial isolates. We show that these Metagenomic Islands (MIs) are also visible in bacteria living in human hosts when their genomes are compared to sequences from the human microbiome, despite the compartmentalized structure of human-related environments such as the gut. From an applied point of view, MIs of human pathogens (e.g. those identified in enterohaemorragic Escherichia coli against the gut metagenome or in pathogenic Neisseria meningitidis against the oral metagenome) include virulence genes that appear to be absent in related strains or species present in the microbiome of healthy individuals. We propose that this strategy (i.e. recruitment analysis of pathogenic bacteria against the metagenome of healthy subjects) can be used to detect pathogenicity regions in species where the genes involved in virulence are poorly characterized. Using this approach, we detect well-known pathogenicity islands and identify new potential virulence genes in several human pathogens.

Pedro Belda-ferre; Raúl Cabrera-rubio; Andrés Moya; Alex Mira

2011-01-01T23:59:59.000Z

110

A PHILOSOPHICAL VIEW OF CIVILIZATION  

Science Journals Connector (OSTI)

Publisher Summary Civilization comprises the dynamic interchange or “transaction” between three open entities—human nature, values and environment, physical and ideal—and can be understood only as their “emergence” or “transcendence.” The scientific and technological age views civilization in East or West largely in the context of man's control and manipulation of nature. The furniture and appurtenances of civilized living, the scaffolding and the frame-work rather than the mansion itself loom larger in the picture. However, the mansion of civilization is represented by the insights, appreciations, values and aspirations of mankind. It is these enduring experiences of the race which embody the essence of civilization and should obtain primary consideration in any adequate treatment. As the philosophy of science and technology makes a tour round the globe, the meanings, appreciations, and values that civilization actually experiences in its orientation to cosmos and to existence as a whole are discounted as metaphysical and religious—irrelevant for modern secular culture.

RADHAKAMAL MUKERJEE

2014-01-01T23:59:59.000Z

111

A View from the Bridge - DOE Perspective | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

A View from the Bridge - DOE Perspective A View from the Bridge - DOE Perspective Broad view of DOE's approach to addressing transportation sector oil dependence...

112

Better Buildings Network View | April 2014 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Network View | April 2014 Better Buildings Network View | April 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings...

113

The Better Buildings Neighborhood View- October 2012  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Neighborhood View monthly newsletter from the U.S. Department of Energy's Better Buildings Neighborhood Program - October 2012

114

Fibrations and universal view updatability Michael Johnson  

E-Print Network (OSTI)

Fibrations and universal view updatability Michael Johnson Computing Department, Macquarie methods to manage the complexity. Dampney and Johnson [25] first showed how data models based on entity

Johnson, Michael

115

Fibrations and universal view updatability Michael Johnson  

E-Print Network (OSTI)

Fibrations and universal view updatability Michael Johnson Computing Department, Macquarie and Johnson [25] first showed how data models based on entity-relationship (ER) diagrams [10] are enhanced

Rosebrugh, Robert

116

A Long View Of The Energy Market  

Science Journals Connector (OSTI)

A Long View Of The Energy Market ... Billionaire philanthropist and Microsoft Chairman Bill Gates and Nobel Prize-winning physicist and Energy Secretary Steven Chu hold similar views on the importance of finding new sources of inexpensive energy to better the plight of the world’s poor—as well as to make money. ...

JEFF JOHNSON

2012-03-19T23:59:59.000Z

117

User_Sup_ViewEmpMatrix  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

an Employee Matrix (Supervisor) an Employee Matrix (Supervisor) © 2011 SuccessFactors, Inc. - 1 - SuccessFactors Learning Confidential. All rights reserved. Job Aid: Viewing an Employee Matrix (Supervisor) Purpose The purpose of this job aid is to guide supervisor users through the step-by-step process of viewing an employee matrix within SuccessFactors Learning. Task A. View an Employee Matrix From the Home page, click the My Employees tab. Click the Employee Matrix supervisor link. Click the Change Measures expand arrow ( ) to select criteria for comparison. View an Employee Matrix 8 Steps Task A 3 3 1 1 2 2 SuccessFactors Learning v 6.4 User Job Aid Viewing an Employee Matrix (Supervisor) © 2011 SuccessFactors, Inc. - 2 - SuccessFactors Learning Select a measure for the

118

Mountain View Grand | Open Energy Information  

Open Energy Info (EERE)

Grand Grand Jump to: navigation, search Name Mountain View Grand Facility Mountain View Grand Sector Wind energy Facility Type Small Scale Wind Facility Status In Service Owner Mountain View Grand Developer Sustainable Energy Developments Energy Purchaser Mountain View Grand Location Mountain View Grand Resort & Spa NH Coordinates 44.397987°, -71.590306° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":44.397987,"lon":-71.590306,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

119

www.advmat.de www.MaterialsViews.com  

E-Print Network (OSTI)

­DNA nanoparticles display relatively high levels of transfection efficiency in cell culture, their per- formance Cui, Erik Luijten,* and Hai-Quan Mao* Plasmid-Templated Shape Control of Condensed DNA­Block Copolymer Plasmid condensation by cationic polymers in aqueous solutions has been widely used to prepare DNA

Mohseni, Hooman

120

Lake View Geothermal Facility | Open Energy Information  

Open Energy Info (EERE)

Page Page Edit with form History Facebook icon Twitter icon » Lake View Geothermal Facility Jump to: navigation, search GEOTHERMAL ENERGYGeothermal Home Lake View Geothermal Facility General Information Name Lake View Geothermal Facility Facility Lake View Sector Geothermal energy Location Information Location The Geysers, California Coordinates 38.823527148671°, -122.78173327446° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":38.823527148671,"lon":-122.78173327446,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


121

Berkeley Lab View -- March 28, 2008  

NLE Websites -- All DOE Office Websites (Extended Search)

March 28th, 2008 Search the View Archive March 28th, 2008 Search the View Archive State of the Lab: New Initiatives, Construction Daniel Chemla (1940-2008): A Remembrance of His Career The View is Going Green DOE Excellence Award to Foundry Project Team Berkeley Lab View Here Comes BELLA: The BErkeley Lab Laser Acceleration Project Berkeley Lab Science Roundup State of the Lab: New Initiatives, Construction By Lynn Yarris image Photo by Roy Kaltschmidt, CSO Free electron lasers with attosecond capabilities, a high-energy electron accelerator less than a meter in length, the arrival of NERSC-6 and the departure of GELCO-4 were some of the highlights of Berkeley Lab Director Steve Chu's State-of-the-Lab address, which he delivered at the Building 50 Auditorium during the noon hour on March 10, with simulcast to the

122

JOBAID-VIEWING AN EMPLOYEE MATRIX (SUPERVISOR)  

Energy.gov (U.S. Department of Energy (DOE))

The purpose of this job aid is to guide supervisor users through the step-by-step process of viewing an employee matrix within SuccessFactors Learning.

123

Incorporating video into Google Mobile Street View  

E-Print Network (OSTI)

Mobile Street View is a compelling application but suffers from significant latency problems, especially in limited bandwidth circumstances. Currently, the application uses static images to display street level information. ...

Wright, Christina (Christina E.)

2010-01-01T23:59:59.000Z

124

1,425 Views Healthcare Technology  

E-Print Network (OSTI)

Molecules into Targeted Cells (/healthtech/1863- nanotechnology/6022- researchers;NANOTECHNOLOGY (/HEALTHTECH/1863-NANOTECHNOLOGY) May 22, 2013 View Comments (/healthtech/1863-nanotechnology/6022, diagnostics, and drug delivery toward the promise of personalized medicine." A paper describing the research

Espinosa, Horacio D.

125

Jefferson and Hamilton as viewed by historians  

E-Print Network (OSTI)

JEFFERSON AND HAMILTON AS VIEHED BY HISTORIANS A Thesis Paul Edward Jungmeyer Submitted to the Graduate College of Texas A&M University in ' partial fulfillment of the requirement for the degree of MASTER OF ARTS August, 1970 Major Subject...: History JEFFERSON AND HAMILTON AS VIEWED BY HISTORIANS A Thesis by Paul Edward Jungmeyer Approved as to style and content by: (Chairman of Committee d i~) (Member) (M er) August, 1970 ABSTRACT JEFFERSON AND HAMILTON AS VIEWED BY HISTORIANS...

Jungmeyer, Paul Edward

2012-06-07T23:59:59.000Z

126

Better Buildings Network View | January 2014 | Department of...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

January 2014 Better Buildings Network View | January 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential...

127

Better Buildings Network View | March 2014 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

March 2014 Better Buildings Network View | March 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential...

128

Better Buildings Network View | May 2014 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

May 2014 Better Buildings Network View | May 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network....

129

Better Buildings Network View | September 2014 | Department of...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

September 2014 Better Buildings Network View | September 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential...

130

Better Buildings Network View | February 2014 | Department of...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

February 2014 Better Buildings Network View | February 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential...

131

Better Buildings Network View | June 2014 | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

June 2014 Better Buildings Network View | June 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network....

132

Valley View Wind Farm | Open Energy Information  

Open Energy Info (EERE)

Wind Farm Wind Farm Jump to: navigation, search Name Valley View Wind Farm Facility Valley View Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner Juhl Wind Developer Valley View Transmission Energy Purchaser Xcel Energy Location Outside Chandler MN Coordinates 43.905808°, -96.020508° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":43.905808,"lon":-96.020508,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

133

Business Apps List View | Data.gov  

NLE Websites -- All DOE Office Websites (Extended Search)

Apps List View Apps List View BusinessUSA Data/Tools Apps Challenges Let's Talk BusinessUSA You are here Data.gov » Communities » BusinessUSA List View Showing 1 - 12 of 12 results. Resources sort ascending Type Last Updated On Traveling Entrepreneur Find green government opportunities for small businesses. The app based on your current location retrieves all the government programs and then allows you to share your favorite program on Facebook. Mobile 02/01/2012 Small Business Toolkit Small Business Toolbox provides a way to easily keep up-to-date on government programs, grants, awards, solicitations, and small business programs. Find the closest SBA district office, easily gathering license and permit information. Mobile 01/31/2012 SBIR.gov Awards Search This app allows users to search the SBIR awards database by agency, keyword, and year.

134

states apps list view | Data.gov  

NLE Websites -- All DOE Office Websites (Extended Search)

states apps list view states apps list view States Data Apps Challenges Policies States You are here Data.gov » Communities » States List View Showing 1 - 5 of 5 results. Resources sort ascending Type Last Updated On TrashBackwards Trash Backwards will connect you with current recycling information, Do It Yourself reuse and upcycle tutorials that are easy to follow, reliable articles and infographics, upcycled products and durable alternatives to common single-use items, and links to non-profits and other groups who will benefit greatly from the stuff you're done with. Currently includes Massachusetts and Washington. Apps 02/27/2013 MoDOT's Traveler Information Map App With the launch of MoDOT's new Traveler Information Map mobile app, Missouri travelers can get the latest information on road conditions, work zones, flooding and incidents on their iPhones and Androids. Mobile 05/22/2013

135

Toto the Robot Figure 1. Toto, front view. Figure 2. Toto, rear view.  

E-Print Network (OSTI)

Toto the Robot Figure 1. Toto, front view. Figure 2. Toto, rear view. Toto the Robot was created so in the back to allow the tape- recorder to be held inside, and the figure was spray-painted. With his metallic a robot, helps account for his lack of verbal charm. Second, some younger children may recognize in Toto

Indiana University

136

Global Food Security Programme Exploring public views  

E-Print Network (OSTI)

Global Food Security Programme ­ Exploring public views #12;©TNS June 2012 -1- Executive Summary significant public policy issues of this century. This scoping study for the Global Food Security programme. The project involved a total of 44 people in a two stage workshop process in London, Edinburgh and Aberystwyth

137

Evolution of self-incompatibility: Early Views  

E-Print Network (OSTI)

Evolution of self-incompatibility: Early Views: Whitehouse (1950): 1. Sudden rise of angiosperms by Whitehouse (1950). Isolation of components of the self-incompatibilities paved the way to study the evolution of SIs Matton et al. (1994): Molecular data supports Bateman. Three self-incompatibility systems

Bhattacharyya, Madan Kumar

138

CITY OF MOUNTAIN VIEW April 12, 2011 .  

E-Print Network (OSTI)

Ordinance ordinance? Projected effective date: September 1, 2011 Green building or stand-alone energy Energy Ordinance in Combination with Green Building ordinance? Do minimum energy requirements increase No afterCITY OF MOUNTAIN VIEW April 12, 2011 . CaUfomia Energy Commission Attn: Joe Loyer 1516 Ninth

139

Friction in full view A. P. Merklea  

E-Print Network (OSTI)

Friction in full view A. P. Merklea and L. D. Marksb Materials Science and Engineering proposed friction mechanisms explaining the unique tribological properties of graphite. Wear of graphite chemical or struc- tural information from the interface during a friction experi- ment. Examples

Marks, Laurence D.

140

Enlightening News and Views FM Employees  

E-Print Network (OSTI)

FM Light Enlightening News and Views From & For FM Employees November 17, 2011 Department Christmas Social Events Scholarship Winner Mechanical Rooms Clean-up Letters Let's Talk Shop SPAN on your big win Sheri! Christmas Social Events NAPE 7801 Dinner and Dance will be held at the Legion

deYoung, Brad

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


141

Enlightening News and Views FM Employees  

E-Print Network (OSTI)

FM Light Enlightening News and Views From & For FM Employees March 11, 2011 Department or five families have a better Christmas. Above from left to right are Yvette Walton of SPAN and Kim Wal-Mart gift certificates to the Christmas Pro- gram of The Salvation Army in December. The Salvation

deYoung, Brad

142

INVESTIGATION Retrospective View of North American Potato  

E-Print Network (OSTI)

INVESTIGATION Retrospective View of North American Potato (Solanum tuberosum L.) Breeding in the 20, Madison, Wisconsin, 53706 ABSTRACT Cultivated potato (Solanum tuberosum L.), a vegetatively propagated explore the effects of potato breeding at the genome level, we used 8303 single-nucleotide polymorphism

Douches, David S.

143

Year in Review 2007 GoddardView  

E-Print Network (OSTI)

Year in Review 2007 GoddardView National Aeronautics and Space Administration www.nasa.gov Volume 4, to stunning images from the highest-resolution satellite data products ever realized, to a visit from Security staff did a marvelous job in planning and coordinating the efforts of at least six different

Christian, Eric

144

Defective extracellular calcium (Cao)-sensing receptor (CaR)-mediated stimulation of a Ca2+-activated potassium channel in glioblastoma cells transfected with a dominant negative CaR  

Science Journals Connector (OSTI)

Glioblastoma cells exhibit several forms of sensitivity to extracellular calcium (Cao) that might be conferred by the Cao-sensing receptor (CaR) that is intimately involved in the maintenance of Cao homeostasis by various cell types. This receptor is expressed in human glioblastoma cell line, U87, and here we show that CaR activators stimulate a Ca2+-activated potassium (K+) channel (CAKC) with a conductance of 140 pS. The responses to CaR activators, however, were blunted in U87 cells transfected with a CaR bearing an inactivating mutation (R185Q) that has previously been shown to exert a dominant negative (DN) action on the wild type receptor. Raising Cao from 0.75 to 2.0 mM or addition of a polycationic CaR agonist, each activated CAKC in nontransfected wild type and empty vector-transfected U87 cells, while they had little or no effect on channel activity in cells expressing the DN CaR (DN-CaR cells). In nontransfected wild type and empty vector-transfected cells, the specific ‘calcimimetic’ CaR activator, NPS R-467, stimulated the channel, while its less active stereoisomer, NPS S-467, did not. In DN-CaR cells, in contrast, NPS R-467, had no effect on channel activity, suggesting defective coupling of the CaR to this ion channel. CaR-mediated stimulation of these K+ channels could lead to membrane repolarization and related changes in cellular function under normal conditions. Since the R185Q mutation in the CaR produces a more severe phenotype in humans than most inactivating mutations of this receptor, some of its clinical consequences could potentially result from abnormal CaR-dependent channel functioning.

Chianping Ye; Naibedya Chattopadhyay; Edward M Brown; Peter M Vassilev

2000-01-01T23:59:59.000Z

145

SOAJ Search : Main View : Deep Federated Search  

Office of Scientific and Technical Information (OSTI)

SOAJ Search SOAJ Search Search Powered By Deep Web Technologies New Search Preferences Powered by Deep Web Technologies HOME ABOUT ADVANCED SEARCH CONTACT US HELP Science Open Access Journals (SOAJ) Science Open Access Journals Main View This view is used for searching all possible sources. Additional Information Keyword: Title: Additional Information Author: Fields to Match: All Any Field(s) Additional Information Date Range: Beginning Date Range Pick Year 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 toEnding Date Range Pick Year 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 DWT Logo Search Clear All Help Simple Search Select All

146

Reasearch apps list view | Data.gov  

NLE Websites -- All DOE Office Websites (Extended Search)

Reasearch apps list view Reasearch apps list view Research Menu Data/Tools Apps Resources Let's Talk Research Alpha You are here Data.gov » Communities » Research Applications Showcase Showing 1 - 6 of 6 results. Resources sort ascending Type Last Updated On Wireless Spectrum Research & Development Senior Steering Group's Testbed Information Portal The Wireless Spectrum Research & Development Senior Steering Group's Testbed Information Portal provides information about spectrum testing facilities to government, academic, and industry researchers in need of such facilities. Apps 11/20/2012 The R&D Dashboard The R&D Dashboard beta website provides an initial look at U.S. Federal investments in science and research from two agencies: the National Institutes of Health (NIH) and the National Science Foundation (NSF) from years 2000-2009. The R&D Dashboard will expand in a future iteration to include ALL Federal research and development spending and expanded information on outputs. Apps 11/20/2012

147

consumer apps list view | Data.gov  

NLE Websites -- All DOE Office Websites (Extended Search)

consumer apps list view consumer apps list view Consumer Data Apps Challenges Resources About Blogs Let's Talk Feedback Consumer You are here Data.gov » Communities » Consumer Smart Disclosure Apps This page highlights apps and websites that use Smart Disclosure-style data to empower consumers to make better informed choices. The purpose is to illustrate the kinds of innovative apps-web- and mobile-based-that Smart Disclosure can fuel. The galleries below include both government-produced apps and apps created by innovators outside government that have won Federal challenges. Showing 1 - 19 of 19 results. Resources sort ascending Type Last Updated On Smart Traveler Smart Traveler, the official State Department app for U.S. travelers, invites you to see the world with easy access to frequently updated official country information, travel alerts, travel warnings, maps, U.S. embassy locations, and more. Mobile 09/14/2012

148

Approaching Inner Ear Hair Cell Regeneration Through Non-Viral Gene Delivery  

E-Print Network (OSTI)

treated with Y-27632 ROCK Inhibitor outperformed untreated cells in transfection efficiency and cell viability by factors of four and three, respectively. The identification and tracking of positively transfected cells was tremendously improved by use of a...

Mellott, Adam Joseph

2014-05-31T23:59:59.000Z

149

An nual En ergy Re view 2001  

Gasoline and Diesel Fuel Update (EIA)

An nual En ergy Re view 2001 An nual En ergy Re view 2001 The An nual En ergy Re view (AER) pres ents the En ergy In for ma tion Ad min - is tra tion's his tor i cal en ergy sta tis tics. For many se ries, sta tis tics are given for ev ery year from 1949 through 2001. The sta tis tics, ex pressed in ei ther phys i cal units or Brit ish ther mal units, cover all ma jor en ergy ac tiv i ties, in - clud ing con sump tion, pro duc tion, trade, stocks, and prices, for all ma jor en - ergy com mod i ties, in clud ing fos sil fu els, elec tric ity, and re new able en ergy sources. Pub li ca tion of this re port is re quired un der Pub lic Law 95-91 (De part ment of En ergy Or ga ni za tion Act), Sec tion 205(c), and is in keep ing with re spon - si bil i ties given to the En ergy In for ma tion Ad min is tra tion un der Sec tion

150

Most Viewed Documents - Renewable Energy | OSTI, US Dept of Energy, Office  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - Renewable Energy Most Viewed Documents - Renewable Energy Seventh Edition Fuel Cell Handbook NETL (2004) Chapter 11. Heat Exchangers Rafferty, Kevin D.; Culver, Gene (1998) Heat Treatment Procedure Qualification -- Final Technical Report Robert C. Voigt (2004) Electric power high-voltage transmission lines: Design options, cost, and electric and magnetic field levels Stoffel, J.B.; Pentecost, E.D.; Roman, R.D.; et al. (1994) Metals design handbook Betts, W.S. (1988) Conduction heat transfer solutions VanSant, J.H. (1980) Lunar Wireless Power Transfer Feasibility Study Sheldon Freid, et al. (2008) The influence of grain size on the mechanical properties ofsteel Morris Jr., J.W. (2001) Fatigue design curves for 6061-T6 aluminum Yahr, G.T. (1993) Chapter 13. Absorption Refrigeration

151

April 2013 Most Viewed Documents for Renewable Energy Sources | OSTI, US  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Renewable Energy Sources April 2013 Most Viewed Documents for Renewable Energy Sources Chapter 11. Heat Exchangers Rafferty, Kevin D.; Culver, Gene (1998) 1252 Seventh Edition Fuel Cell Handbook NETL (2004) 628 Wet cooling towers: rule-of-thumb design and simulation Leeper, S.A. (1981) 290 Chapter 17. Engineering cost analysis Higbee, Charles V. (1998) 223 Geothermal Power Generation - A Primer on Low-Temperature, Small-Scale Applications Rafferty, K. (2000) 197 Calculation of brine properties. [Above 80/sup 0/F and for salt content between 5 and 25%] Dittman, G.L. (1977) 183 Chapter 13. Absorption Refrigeration Rafferty, Kevin D. (1998) 176 A study of lead-acid battery efficiency near top-of-charge and the impact on PV system design Stevens, J.W.; Corey, G.P. (1996) 173 Temperature coefficients for PV modules and arrays: Measurement

152

Solar Viewed as Triple Boon for Bishop Paiute Tribe | Department...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Solar Viewed as Triple Boon for Bishop Paiute Tribe Solar Viewed as Triple Boon for Bishop Paiute Tribe July 1, 2014 - 8:00am Addthis What does this project do? Tribal participants...

153

Cellulosic Biofuels: Expert Views on Prospects for Advancement: Supplementary Material  

E-Print Network (OSTI)

Cellulosic Biofuels: Expert Views on Prospects for Advancement: Supplementary Material Erin Baker Keywords: Biofuels; Technology R&D; Uncertainty; Environmental policy 2 #12;1 Introduction This paper contains supplementary material for "Cellulosic Biofuels: Expert Views on Prospects for Advancement

Massachusetts at Amherst, University of

154

Enabling View-Dependent Stereoscopic Projection in Real Environments  

Science Journals Connector (OSTI)

We show how view-dependent image-based and geometric warping, radiometric compensation, and multi-focal projection enable a view-dependent stereoscopic visualization on ordinary (geometrically complex, colored and textured) surfaces within everyday environments. ...

Oliver Bimber; Gordon Wetzstein; Andreas Emmerling; Christian Nitschke

2005-10-01T23:59:59.000Z

155

Better Buildings Network View | July-August 2014 | Department...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

July-August 2014 Better Buildings Network View | July-August 2014 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings...

156

news & views nature genetics volume 29 october 2001 105  

E-Print Network (OSTI)

news & views nature genetics · volume 29 · october 2001 105 Since the sequence of the yeast genome

Church, George M.

157

Better Buildings Network View | July-August 2014  

Energy.gov (U.S. Department of Energy (DOE))

The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's Better Buildings Residential Network.

158

Energy Efficiency in Buildings- the Utilities View  

E-Print Network (OSTI)

PAGE 1 Energy Efficiency in Buildings - the Utilities View U. K?nig RWE Energy AG The energy to lead ESL-IC-08-10-27 Proceedings of the Eighth International Conference for Enhanced Building Operations, Berlin, Germany, October 20-22, 2008 RWE... International Conference for Enhanced Building Operations, Berlin, Germany, October 20-22, 2008 RWE Energy / Energieeffizienz bei Immobilien / U. K?nig / ICEBO '08 SEITE 3 RWE ? One of the five leading Energy Companies in Europe > Nr 1 producer of electricity...

Konig, U.

159

A New View of the Cosmic Landscape  

E-Print Network (OSTI)

In this scenario, a generic meta-stable deSitter vacuum site in the cosmic landscape in string theory has a very short lifetime. Typically, the smaller is the vacuum energy of a meta-stable site, the longer is its lifetime. This view of the landscape can provide a qualitative dynamical explanation why the dark energy of our universe is so small. The argument for this scenario is based on resonance tunneling, a well-known quantum mechanical phenomenon, the topography of the landscape, and the vastness of the cosmic landscape. Mapping the topography of the landscape, even if only in a small region, will test the validity of this scenario.

S. -H. Henry Tye

2007-04-16T23:59:59.000Z

160

Effects of BPA and E2 on expression profiles of genes related to hypothalamic-pituitary-gonadal axis of half-smooth tongue sole Cynoglossus semilaevis  

Science Journals Connector (OSTI)

Endocrine disrupting chemicals (EDCs) are increasingly viewed as persistent pollutants, similar to natural hormones in function. This paper describes the expression profiles of 7 genes (DMRT, VTG GnRHR FSHR CYP17...

Fengling Li ???; Zhaoxin Li ???…

2013-05-01T23:59:59.000Z

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


161

Mountain View IV | Open Energy Information  

Open Energy Info (EERE)

IV IV Facility Mountain View IV Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner AES Wind Generation Developer AES Wind Generation Energy Purchaser Southern California Edison Co Location White Water CA Coordinates 33.95475187°, -116.7015839° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":33.95475187,"lon":-116.7015839,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

162

Study advances view of geopressure seals  

SciTech Connect

The last decade has seen a growing interest in the subject of fluid pressure seals and fluid flow in hydrocarbon-bearing basins. As explorationists begin to view basins in terms of coupled, dynamic, chemical, and physical processes, seemingly unrelated observations become interrelated. It is precisely the integration of geological, geochemical, and geophysical observations that opens the door for new exploration opportunities. This article lays a conceptual foundation in the area of geopressure seals and on the role of geopressure in hydrocarbon migration and accumulation in young, clastic basins. The exploration significance of geopressure can be appreciated when one considers that within the gulf Coast basin, geopressured fields, which represent only 10% of the total number of fields, account for approximately 50% of the cumulative production.

Benzing, W.M.; Shook, G.M. [Idaho National Engineering Lab., Idaho Falls, ID (United States)

1996-05-20T23:59:59.000Z

163

View Discovery in OLAP Databases through Statistical Combinatorial Optimization  

SciTech Connect

The capability of OLAP database software systems to handle data complexity comes at a high price for analysts, presenting them a combinatorially vast space of views of a relational database. We respond to the need to deploy technologies sufficient to allow users to guide themselves to areas of local structure by casting the space of ``views'' of an OLAP database as a combinatorial object of all projections and subsets, and ``view discovery'' as an search process over that lattice. We equip the view lattice with statistical information theoretical measures sufficient to support a combinatorial optimization process. We outline ``hop-chaining'' as a particular view discovery algorithm over this object, wherein users are guided across a permutation of the dimensions by searching for successive two-dimensional views, pushing seen dimensions into an increasingly large background filter in a ``spiraling'' search process. We illustrate this work in the context of data cubes recording summary statistics for radiation portal monitors at US ports.

Joslyn, Cliff A.; Burke, Edward J.; Critchlow, Terence J.

2009-05-01T23:59:59.000Z

164

January 2013 Most Viewed Documents for Mathematics And Computing...  

Office of Scientific and Technical Information (OSTI)

January 2013 Most Viewed Documents for Mathematics And Computing Cybersecurity through Real-Time Distributed Control Systems Kisner, Roger A ORNL; Manges, Wayne W ORNL;...

165

March 2014 Most Viewed Documents for National Defense | OSTI...  

Office of Scientific and Technical Information (OSTI)

2014 Most Viewed Documents for National Defense Science Subject Feed The Effects of Nuclear Weapons Glasstone, Samuel (1964) 72 SMART BRIDGE: A tool for estimating the military...

166

The Better Buildings Neighborhood View - December 2013 | Department...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

- July 2013 Focus Series: Philadelphia Energyworks: In the City of Brotherly Love, Sharing Know-How Leads to Sustainability The Better Buildings Neighborhood View - October 2012...

167

September 2013 Most Viewed Documents for Fission And Nuclear...  

Office of Scientific and Technical Information (OSTI)

September 2013 Most Viewed Documents for Fission And Nuclear Technologies Science Subject Feed Estimation of gas leak rates through very small orifices and channels. From sealed...

168

January 2013 Most Viewed Documents for Fission And Nuclear Technologie...  

Office of Scientific and Technical Information (OSTI)

January 2013 Most Viewed Documents for Fission And Nuclear Technologies Laboratory studies of shearleach processing of zircaloy clad metallic uranium reactor fuel Swanson, J.L.;...

169

January 2013 Most Viewed Documents for Chemistry | OSTI, US Dept...  

Office of Scientific and Technical Information (OSTI)

January 2013 Most Viewed Documents for Chemistry Dialkylenecarbonate-Bridged Polysilsesquioxanes. Hybrid Organic-Inorganic Sol-Gels with a Thermally Labile Bridging Group Assink,...

170

A HYPERSPECTRAL VIEW OF THE CRAB NEBULA  

SciTech Connect

We have obtained spatially resolved spectra of the Crab nebula in the spectral ranges 450-520 nm and 650-680 nm, encompassing the H{beta}, [O III] {lambda}4959, {lambda}5007, H{alpha}, [N II] {lambda}6548, {lambda}6584, and [S II] {lambda}6717, {lambda}6731 emission lines, with the imaging Fourier transform spectrometer SpIOMM at the Observatoire du Mont-Megantic's 1.6 m telescope. We first compare our data with published observations obtained either from a Fabry-Perot interferometer or from a long-slit spectrograph. Using a spectral deconvolution technique similar to the one developed by Cadez et al., we identify and resolve multiple emission lines separated by large Doppler shifts and contained within the rapidly expanding filamentary structure of the Crab. This allows us to measure important line ratios, such as [N II]/H{alpha}, [S II]/H{alpha}, and [S II] {lambda}6717 /[S II] {lambda}6731 of individual filaments, providing a new insight on the SE-NW asymmetry in the Crab. From our analysis of the spatial distribution of the electronic density and of the respective shocked versus photoionized gas components, we deduce that the skin-less NW region must have evolved faster than the rest of the nebula. Assuming a very simple expansion model for the ejecta material, our data provide us with a complete tridimensional view of the Crab.

Charlebois, M.; Drissen, L.; Bernier, A.-P. [Departement de Physique, de Genie Physique et d'Optique, Universite Laval, Quebec, Quebec G1V 0A6 (Canada); Grandmont, F. [ABB Bomem Inc., 585 boulevard Charest est, Suite 300, Quebec, Quebec G1K 9H4 (Canada); Binette, L., E-mail: maxime.charlebois.1@ulaval.c, E-mail: ldrissen@phy.ulaval.c, E-mail: anne-pier.bernier.1@ulaval.c [Instituto de AstronomIa, UNAM, Ap.70-264, 04510 Mexico, DF (Mexico)

2010-05-15T23:59:59.000Z

171

Performance viewing and editing in ASSESS Outsider  

SciTech Connect

The Analytic System and Software for Evaluation of Safeguards and Security (ASSESS) Facility module records site information in the path elements and areas of an Adversary Sequence Diagram. The ASSESS Outsider evaluation module takes this information and first calculates performance values describing how much detection and delay is assigned at each path element and then uses the performance values to determine most-vulnerable paths. This paper discusses new Outsider capabilities that allow the user to view how elements are being defeated and to modify some of these values in Outsider. Outsider now displays how different path element segments are defeated and contrasts the probability of detection for alternate methods of defeating a door (e.g., the lock or the door face itself). The user can also override element segment delays and detection probabilities directly during analysis in Outsider. These capabilities allow users to compare element performance and to verify correct path element performance for all elements, not just those on the most-vulnerable path as is the case currently. Improvements or reductions in protection can be easily checked without creating a set of new facility files to accomplish it.

Snell, M.K. [Sandia National Labs., Albuquerque, NM (US); Key, B.; Bingham, B. [Science and Engineering Associates, Inc., Albuquerque, NM (US)

1993-07-01T23:59:59.000Z

172

The INTEGRAL View of the Galactic Nucleus  

E-Print Network (OSTI)

We present the preliminary results of the observational campaign performed in 2003 to study the Galactic Nucleus with INTEGRAL. The mosaicked images obtained with the IBIS/ISGRI coded aperture instrument in the energy range above 20 keV, give a yet unseen view of the high-energy sources of this region in hard X and gamma-rays, with an angular resolution of 12'. We report on the discovery of a source, IGR J17456-2901, compatible with the instrument's point spread function and coincident with the Galactic Nucleus Sgr A* to within 0.9'. The source is visible up to 60-80 keV with a 20-100 keV luminosity at 8 kpc of 3 x 10E35 erg/s. Although we cannot unequivocally associate the new INTEGRAL source to the Galactic Nucleus, this is the first report of significant hard X-ray emission from within the inner 10' of the Galaxy and a contribution from the galactic center supermassive black hole itself cannot be excluded. Here we discuss the results obtained and the perspectives for future observations of the Galactic Nuc...

Goldwurm, A; Goldoni, P; Paul, J; Terrier, R; Falanga, M; Ubertini, P; Bazzano, A; Santo, M D; Winkler, C; Parmar, A N; Kuulkers, E; Ebisawa, K; Roques, J P; Skinner, G K; Lund, N; Melia, F; Yusef-Zadeh, F

2004-01-01T23:59:59.000Z

173

Gene expression and evolution  

E-Print Network (OSTI)

Visualization of individual Scr mRNAs during Drosophilaof the homeotic gene Scr associated with a crustacean leg-as in Kosman et al. , 2004. SCR and ABD-B antibodies were

Lemons, Derek Scott

2010-01-01T23:59:59.000Z

174

Nanomedicine for gene therapy  

Science Journals Connector (OSTI)

Viruses are promising vehicles that result in high gene expression level, but issues of safety and virulent nature prevented its extensive use. Therefore, nonviral approach was investigated with the intervention ...

Susan Muthe Alex; Chandra P. Sharma

2013-10-01T23:59:59.000Z

175

A Comprehensive View of Nuclear Receptor Cancer Cistromes  

Science Journals Connector (OSTI)

...exon and gene expression arrays datasets. Differential gene expression...lesions was applied to four public datasets. Small nuclear ribonucleoprotein E (SNRPE...confirmed in four different public dataset on breast, ovarian, lung and...

Qianzi Tang; Yiwen Chen; Clifford Meyer; Tim Geistlinger; Mathieu Lupien; Qian Wang; Tao Liu; Yong Zhang; Myles Brown; and Xiaole Shirley Liu

2011-11-15T23:59:59.000Z

176

CAP‘n’Collar Genes (CNC)  

Science Journals Connector (OSTI)

CNC genes are basic leucine zipper transcription factor... DNA binding protein domains , homeotic genes

2008-01-01T23:59:59.000Z

177

OVARIAN CANCER GENE THERAPY  

Science Journals Connector (OSTI)

Although systemic gene therapy is certainly the ultimate goal for strategies directed towards patient cancer therapy, present problems with systemic vector delivery suggest that initial gene therapy strategies may involve regional approaches directed towards the few specific tumors that exhibit a predominantly regional pattern of spread: ovarian cancers and brain tumors. The model system of metastatic ovarian cancer growing within peritoneal fluid has several advantages of safety and efficacy for retroviral-mediated gene transfer into solid tumors. First, the pathology of metastasis into mesothelial-lined spaces consists of relatively thin tumor plaques with extravasation of cancer cells into the fluid, potentially allowing a reservoir for delivering retroviral vectors to malignant cells. This spreading pattern is in contrast to primary tumors and more solid metastatic sites, where cancer grows as a large three-dimensional mass that could prevent delivery of retroviral vectors or other agents into the majority of tumor cells. In addition, infusion of retroviral vectors into these fluids should produce a greater effect on the growing cells within the fluid (predominantly cancer cells) than on proliferating host cells in regions of the body that do not directly connect to the mesothelial-lined spaces. Second, ovarian cancer provides a model system in which regional therapy could be curative in a high percentage of cases. This is true because ovarian cancer is confined to the peritoneal cavity at patient presentation in 60% of cases. The uptake and expression of the viral vectors can be readily assessed in these model systems because these fluids are readily accessible for cytologic, biochemical, and molecular analysis. Cancer gene therapy strategies include immunotherapy, introduction of drug sensitivity or resistance genes, oncogene inactivation, introduction of cytolytic genes, and tumor suppressor gene replacement. Examples of gene therapy protocols designed to target ovarian cancer include immunotherapy approaches, introduction of cytolytic genes, and tumor suppressor gene therapy approaches (reviewed in Roth and Cristiano22). The BRCA1 gene is mutated in the majority of cases of hereditary breast and ovarian cancer and exhibits loss of heterozygosity (LOH) and/or decreased expression in many sporadic cases.5,6,7,9,11,16,17,30,31 Multiple studies have demonstrated that overexpression of the BRCA1 gene results in growth inhibition and/or cell death, suggesting that BRCA1 can function directly as a growth inhibitor or tumor suppressor.10,21,28,31,33,34 Alternatively, growth inhibition may not be the major or sole mechanism for tumor suppression,13 because BRCA1 also functions during differentiation8,14,15 and may modulate DNA repair.13,27 The antitumor effect may be due to secretion of the BRCA1 gene product and a resulting paracrine inhibitory effect,12 although the precise biochemical function of BRCA1 is controversial and may involve nuclear functions4,26 such as DNA repair27 or transcriptional activation.3,18 Preclinical studies in nude mice xenografts have shown that intraperitoneal injection of retroviral vectors expressing \\{BRCA1sv\\} (a normal splice variant form of BRCA1) can inhibit the growth of established intraperitoneal tumors.10 Control retroviral vectors do not exhibit a significant antitumor effect, indicating that this is not merely a nonspecific effect of retroviral injection, but an effect of BRCA1 gene transfer.10 These studies showed transduction of tumor cells and expression of BRCA1 mRNA and protein following intraperitoneal injection of established intraperitoneal tumors10 or intratumoral injection of subcutaneous tumors (Obermiller and Holt, unpublished data). This article describes the development and phase I testing of BRCA1 gene therapy for the treatment of ovarian cancer.

David L. Tait; Patrice S. Obermiller; Roy A. Jensen; Jeffrey T. Holt

1998-01-01T23:59:59.000Z

178

Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum  

Science Journals Connector (OSTI)

Four of the plasmepsins of Plasmodium falciparum are localised in the digestive vacuole (DV) of the asexual blood stage parasite (PfPM1, PfPM2, PfPM4 and PfHAP), and each of these aspartic proteinases has been successfully targeted by gene disruption. This study describes further characterisation of the single-plasmepsin knockout mutants, and the creation and characterisation of double-plasmepsin knockout mutants lacking complete copies of pfpm2 and pfpm1 or pfhap and pfpm2. Double-plasmepsin knockout mutants were created by transfecting pre-existing knockout mutants with a second plasmid knockout construct. PCR and Southern blot analysis demonstrate the integration of a large concatamer of each plasmid construct into the targeted gene. All mutants have been characterised to assess the involvement of the DV plasmepsins in sustaining growth during the asexual blood stage. Analyses reaffirmed that knockout mutants ?pfpm1 and ?pfpm4 had lower replication rates in the asexual erythrocytic stage than the parental line (Dd2), but double-plasmepsin knockout mutants lacking intact copies of either pfpm2 and pfpm1, or pfpm2 and pfhap, had normal growth rates compared with Dd2. The amount of crystalline hemozoin produced per parasite during the asexual cycle was measured in each single-plasmepsin knockout to estimate the effect of each DV plasmepsin on hemoglobin digestion. Only ?pfpm4 had a statistically significant reduction in hemozoin accumulation, indicating that hemoglobin digestion was impaired in this mutant. In the single-plasmepsin knockouts, no statistically significant differences were found in the steady state levels of mRNA from the remaining intact DV plasmepsin genes. Disruption of a DV plasmepsin gene does not affect the accumulation of mRNA encoding the remaining paralogous plasmepsins, and Western blot analysis confirmed that the accumulation of the paralogous plasmepsins in each knockout mutant was similar among all clones examined.

J. Alfredo Bonilla; Pedro A. Moura; Tonya D. Bonilla; Charles A. Yowell; David A. Fidock; John B. Dame

2007-01-01T23:59:59.000Z

179

news & views nature genetics volume 33 april 2003 435  

E-Print Network (OSTI)

news & views nature genetics · volume 33 · april 2003 435 Recent papers in Science1 and the AmeriPublishingGrouphttp://www.nature.com/naturegenetics #12;news & views 436 nature genetics · volume 33 · april 2003 the same territory, who are often

Rosenberg, Noah

180

NUFinancials Viewing Post-Award Grant Data in  

E-Print Network (OSTI)

NUFinancials Grants FMS505 Viewing Post-Award Grant Data in NUFinancials 11/25/2013 © 2013 Northwestern University FMS505 1 Viewing Post-Award Grant Data in NUFinancials Before you begin . . . When is this used? This guide is used to review the pages in NUFinancials where Grants data can be accessed. Who has

Shull, Kenneth R.

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


181

View discovery in OLAP databases through statistical combinatorial optimization  

SciTech Connect

OnLine Analytical Processing (OLAP) is a relational database technology providing users with rapid access to summary, aggregated views of a single large database, and is widely recognized for knowledge representation and discovery in high-dimensional relational databases. OLAP technologies provide intuitive and graphical access to the massively complex set of possible summary views available in large relational (SQL) structured data repositories. The capability of OLAP database software systems to handle data complexity comes at a high price for analysts, presenting them a combinatorially vast space of views of a relational database. We respond to the need to deploy technologies sufficient to allow users to guide themselves to areas of local structure by casting the space of 'views' of an OLAP database as a combinatorial object of all projections and subsets, and 'view discovery' as an search process over that lattice. We equip the view lattice with statistical information theoretical measures sufficient to support a combinatorial optimization process. We outline 'hop-chaining' as a particular view discovery algorithm over this object, wherein users are guided across a permutation of the dimensions by searching for successive two-dimensional views, pushing seen dimensions into an increasingly large background filter in a 'spiraling' search process. We illustrate this work in the context of data cubes recording summary statistics for radiation portal monitors at US ports.

Hengartner, Nick W [Los Alamos National Laboratory; Burke, John [PNNL; Critchlow, Terence [PNNL; Joslyn, Cliff [PNNL; Hogan, Emilie [PNNL

2009-01-01T23:59:59.000Z

182

3D Model Retrieval based on Adaptive Views Clustering  

E-Print Network (OSTI)

3D Model Retrieval based on Adaptive Views Clustering Tarik Filali Ansary1 , Mohamed Daoudi2 , Jean.daoudi@univ-tours.fr http://www-rech.enic.fr/miire Abstract. In this paper, we propose a method for 3D model indexing based selection of 2D views from a 3D model, and a probabilistic Bayesian method for 3D model retrieval from

Paris-Sud XI, Université de

183

On the Number of Views of Polyhedral Scenes  

Science Journals Connector (OSTI)

It is known that a scene consiing of k convex polyhedra of total complexity n has at most O(n4 k2) distinct orthographic views, and that the number of such views is ¿((nk2 + n2)2) ...

Boris Aronov; Hervé Brönnimann; Dan Halperin; Robert Schiffenbauer

2000-11-01T23:59:59.000Z

184

A large-scale exploration of group viewing patterns  

Science Journals Connector (OSTI)

We present a large-scale study of television viewing habits, focusing on how individuals adapt their preferences when consuming content with others. While there has been a great deal of research on modeling individual preferences, there has been considerably ... Keywords: group recommendation, group viewing patterns

Allison J.B. Chaney, Mike Gartrell, Jake M. Hofman, John Guiver, Noam Koenigstein, Pushmeet Kohli, Ulrich Paquet

2014-06-01T23:59:59.000Z

185

Nonviral Vectors for Gene Delivery  

E-Print Network (OSTI)

been conducted (http://www.wiley.com/legacy/wileychi/genmed/clinical/). Gene therapies can be categorized on the basis of therapy as gene inhibitors, gene vaccines and gene substitutes. Gene inhibitors (i.e. siRNA) are potent therapies that silence... in formulation design and can be tailored to fit the size and topology of the gene. 1.4.2.1. Natural polymers Over the years, a significant number of natural polymers, such as chitosan 174 , cationic proteins (e.g., polylysine, protamine and histones...

Baoum, Abdulgader Ahmed

2011-04-26T23:59:59.000Z

186

Science Conference Proceedings : Main View : Deep Web Business Search  

Office of Scientific and Technical Information (OSTI)

Main View Main View This view is used for searching all possible sources. A SCIENCE Accelerator Resource Additional Information Search: Search Clear All Conference Collections Welcome to the DOE Office of Scientific and Technical Information's (OSTI) Science Conference Proceedings Portal. This distributed portal provides access to science and technology conference proceedings and conference papers from a number of authoritative sites (professional societies and national labs, largely) whose areas of interest in the physical sciences and technology intersect those of the Department of Energy. Proceedings and papers from scientific meetings can be found in these fields, among others: particle physics, nuclear physics, chemistry, petroleum, aeronautics and astronautics, meteorology, engineering, computer science, electric power,

187

Logan View Public Schools Wind Project | Open Energy Information  

Open Energy Info (EERE)

View Public Schools Wind Project View Public Schools Wind Project Jump to: navigation, search Name Logan View Public Schools Wind Project Facility Logan View Public Schools Sector Wind energy Facility Type Community Wind Location NE Coordinates 41.651546°, -96.50457° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":41.651546,"lon":-96.50457,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

188

How can I view submitted materials? | OpenEI Community  

Open Energy Info (EERE)

view submitted materials? Home > Groups > 2014 Geothermal Case Study Challenge Submitted by NickL on 6 May, 2014 - 07:41 1 answer Points: 0 For various reasons, you may want to...

189

June 2014 Most Viewed Documents for Fission And Nuclear Technologies...  

Office of Scientific and Technical Information (OSTI)

June 2014 Most Viewed Documents for Fission And Nuclear Technologies Behavior of spent nuclear fuel in water pool storage Johnson, A.B. Jr. (1977) 78 Estimation of gas leak rates...

190

July 2013 Most Viewed Documents for Fission And Nuclear Technologies...  

Office of Scientific and Technical Information (OSTI)

July 2013 Most Viewed Documents for Fission And Nuclear Technologies Science Subject Feed Estimation of gas leak rates through very small orifices and channels. From sealed PuO...

191

Data flow abstractions and adaptations through updatable process views  

Science Journals Connector (OSTI)

The increasing adoption of process-aware information systems (PAISs) has resulted in large process model collections. To support users having different perspectives on these processes and related data, a PAIS should enable personalized views on process ...

Jens Kolb; Manfred Reichert

2013-03-01T23:59:59.000Z

192

A Transformational View of Cartography W. R. Tobler  

E-Print Network (OSTI)

A Transformational View of Cartography W. R. Tobler ABSTRACT. Cartographic transformations aliases are between points, lines, and areas. Substantive transformations occur in map interpolation transformational grammars, as originally devised for linguistics.2, 4 A similar, though less ambitious, attempt

Clarke, Keith

193

July 2013 Most Viewed Documents for Chemistry | OSTI, US Dept...  

Office of Scientific and Technical Information (OSTI)

July 2013 Most Viewed Documents for Chemistry Science Subject Feed Lithium literature review: lithium's properties and interactions Jeppson, D.W.; Ballif, J.L.; Yuan, W.W.; Chou,...

194

Prairie View Gas Recovery Biomass Facility | Open Energy Information  

Open Energy Info (EERE)

Prairie View Gas Recovery Biomass Facility Prairie View Gas Recovery Biomass Facility Jump to: navigation, search Name Prairie View Gas Recovery Biomass Facility Facility Prairie View Gas Recovery Sector Biomass Facility Type Landfill Gas Location St. Joseph County, Indiana Coordinates 41.6228085°, -86.3376761° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":41.6228085,"lon":-86.3376761,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

195

Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons  

E-Print Network (OSTI)

Enzy- matic (Active Motif, Carlsbad, CA) with the following™ 2000 (Invitro- gen, Carlsbad, CA) and allowed to incubatedations (Invitrogen, Carlsbad, CA). Overall, transfection

2011-01-01T23:59:59.000Z

196

Huntington's disease Between genes and  

E-Print Network (OSTI)

-base stutter in the DNA of the gene concerned. To a large extent, the length of the repeated section determines

Levin, Yan

197

Bartlett's Ocean View Wind Farm | Open Energy Information  

Open Energy Info (EERE)

Bartlett's Ocean View Wind Farm Bartlett's Ocean View Wind Farm Jump to: navigation, search Name Bartlett's Ocean View Wind Farm Facility Bartlett's Ocean View Wind Farm Sector Wind energy Facility Type Community Wind Facility Status In Service Owner Bartlett's Ocean View Wind Farm Energy Purchaser Bartlett's Ocean View Wind Farm Location Nantucket MA Coordinates 41.259168°, -70.131913° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":41.259168,"lon":-70.131913,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

198

Short-hairpin RNA-mediated Heat shock protein 90 gene silencing inhibits human breast cancer cell growth in vitro and in vivo  

SciTech Connect

Highlights: Black-Right-Pointing-Pointer Hsp90 is over-expressed in human breast cancer. Black-Right-Pointing-Pointer The shRNA-mediated gene silencing of Hsp90 resulted in inhibition of cell growth. Black-Right-Pointing-Pointer Akt and NF-kB were down-regulation after transfection due to Hsp90 silencing. Black-Right-Pointing-Pointer The tumor growth ratio was decline due to Hsp90 silencing. Black-Right-Pointing-Pointer The PCNA expression was down-regulation due to Hsp90 silencing. -- Abstract: Hsp90 interacts with proteins that mediate signaling pathways involved in the regulation of essential processes such as proliferation, cell cycle control, angiogenesis and apoptosis. Hsp90 inhibition is therefore an attractive strategy for blocking abnormal pathways that are crucial for cancer cell growth. In the present study, the role of Hsp90 in human breast cancer MCF-7 cells was examined by stably silencing Hsp90 gene expression with an Hsp90-silencing vector (Hsp90-shRNA). RT-PCR and Western blot analyses showed that Hsp90-shRNA specifically and markedly down-regulated Hsp90 mRNA and protein expression. NF-kB and Akt protein levels were down-regulated in Hsp90-shRNA transfected cells, indicating that Hsp90 knockout caused a reduction of survival factors and induced apoptosis. Treatment with Hsp90-shRNA significantly increased apoptotic cell death and caused cell cycle arrest in the G1/S phase in MCF-7 cells, as shown by flow cytometry. Silencing of Hsp90 also reduced cell viability, as determined by MTT assay. In vivo experiments showed that MCF-7 cells stably transfected with Hsp90-shRNA grew slowly in nude mice as compared with control groups. In summary, the Hsp90-shRNA specifically silenced the Hsp90 gene, and inhibited MCF-7 cell growth in vitro and in vivo. Possible molecular mechanisms underlying the effects of Hsp90-shRNA include the degradation of Hsp90 breast cancer-related client proteins, the inhibition of survival signals and the upregulation of apoptotic pathways. shRNA-mediated interference may have potential therapeutic utility in human breast cancer.

Zuo, Keqiang [Department of General Surgery, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072 (China)] [Department of General Surgery, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072 (China); Li, Dan [Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072 (China)] [Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072 (China); Pulli, Benjamin [Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114 (United States)] [Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114 (United States); Yu, Fei; Cai, Haidong; Yuan, Xueyu [Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072 (China)] [Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072 (China); Zhang, Xiaoping, E-mail: zxpsibs@163.com [Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072 (China)] [Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072 (China); Lv, Zhongwei, E-mail: heyixue163@163.com [Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072 (China)] [Department of Nuclear Medicine, Shanghai 10th People's Hospital, Tongji University School of Medicine, Shanghai 200072 (China)

2012-05-04T23:59:59.000Z

199

Mountain View Electric Association, Inc - Energy Efficiency Credit Program  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Mountain View Electric Association, Inc - Energy Efficiency Credit Mountain View Electric Association, Inc - Energy Efficiency Credit Program Mountain View Electric Association, Inc - Energy Efficiency Credit Program < Back Eligibility Agricultural Commercial Industrial Residential Savings Category Appliances & Electronics Heating & Cooling Commercial Heating & Cooling Heat Pumps Commercial Lighting Lighting Manufacturing Water Heating Maximum Rebate LED Street Lighting: $20,000 LED Refrigerated Case Lighting Retrofit: $3,000 Commercial Lighting Replacement: $20,000 Program Info State Colorado Program Type Utility Rebate Program Rebate Amount Geothermal Heat Pumps: $150/ton, additional $150 per unit for Energy Star units greater than 3 tons, additional $120 if attached to electric water heater Air-Source Heat Pump: $125 - $150/ton, additional $100 - $150 per unit for

200

Science Conference Proceedings : Main View : Deep Web Business Search  

Office of Scientific and Technical Information (OSTI)

Main View Main View This view is used for searching all possible sources. Additional Information Search: Title: Additional Information Author: Match: All Any Field(s) Additional Information Date Range: Beginning Date Range Pick Year 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 toEnding Date Range Pick Year 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 Search Clear All Notice to searchers: Due to the varied configuration and diversity of web pages and databases searched by Science Conference Proceedings, Full Record will search whatever data that is searchable at each site. Author and Title queries are only available on AIAA, AIP, ASCE, ASME, ECD,

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


201

Tools for Viewing and Quality Checking ARM Data  

NLE Websites -- All DOE Office Websites (Extended Search)

Tools for Viewing and Quality Checking ARM Data Tools for Viewing and Quality Checking ARM Data S. Bottone and S. Moore Mission Research Corporation Santa Barbara, California Introduction Mission Research Corporation (MRC) is developing software tools to assist the Atmospheric Radiation Measurement (ARM) Data Quality Office with their data inspection tasks. One such tool is NCVweb, a web-based data analysis and visualization tool that allows for easy viewing of ARM NetCDF data files. This tool helps to eliminate the need of and problems associated with downloading large volumes of data, installing and configuring visualization software, or writing custom data exploration software. It has been upgraded this year with many new features described below. NCVweb can be used at the ARM Data Quality website directly via http://dq.arm.gov/ncvweb/ncvweb.cgi, or via the Data Quality

202

City of Mountain View, Missouri (Utility Company) | Open Energy Information  

Open Energy Info (EERE)

Mountain View Mountain View Place Missouri Utility Id 13057 Utility Location Yes Ownership M NERC Location SERC NERC SERC Yes Activity Distribution Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png Residential Residential Average Rates Residential: $0.0810/kWh Commercial: $0.0807/kWh References ↑ "EIA Form EIA-861 Final Data File for 2010 - File1_a" Retrieved from "http://en.openei.org/w/index.php?title=City_of_Mountain_View,_Missouri_(Utility_Company)&oldid=409985" Categories: EIA Utility Companies and Aliases Utility Companies Organizations Stubs What links here

203

Traits and Multiple Genes  

NLE Websites -- All DOE Office Websites (Extended Search)

Traits and Multiple Genes Traits and Multiple Genes Name: Frank Location: N/A Country: N/A Date: N/A Question: Please, could you give me an example of how human traits are controlled by more than one pair of alleles? Replies: Your question is just a bit vague, there are different answers depending on just what your question is. I will answer it in terms of polygenic traits also known as additive alleles. When you think of traits such as skin color, hair color and eye color, or traits where there is a wide range of phenotypes they are usually under the control of more than one pair of alleles. These alleles can even be on different chromosomes! Each pair of additive alleles adds to the phenotype. For instance in the case of skin color, scientists now believe that 3 genes control skin color. You then get 3 sets from your mother and 3 from your father for 6 possibilities. If all 6 of the alleles are for dark skin, you will have the darkest possible skin. If you have 5 dark alleles and one light, you will have very dark skin. If you have all 6 light alleles then you will have the lightest skin possible. Is it possible to have a child that is light skinned when both parents are dark-skinned? Well, not if both have all 6 dark alleles, but if they have some light alleles and the child inherits all of the possible light alleles available, then yes, the child could have lighter skin than either parent. It is now believed that eye color is not simply brown being dominant over blue because how many people do you know that have the same shade of brown or blue eyes? Eye color must also be polygenic.

204

Recessive and Dominant Gene Action  

NLE Websites -- All DOE Office Websites (Extended Search)

Recessive and Dominant Gene Action Recessive and Dominant Gene Action Name: Katie Location: N/A Country: N/A Date: N/A Question: What Causes some genes to be ressesive and other genes to be dominant? Replies: Think about the fact that genes code for directions for making proteins. There are many different kinds of proteins in our body-enzymes for regulating metabolism, structural proteins for building our bodies, hormones for regulating processes etc. If the gene for the protein is structural, then it is important to have the right kind and the right amount. If the gene is defective (usually recessive genes are defective, but not always) the right protein will not be made and the structure will either be defective and won't work at all or there won't be enough to maintain the structure. Sometimes you need both genes to be working to get enough of the structure. So a homozygous person will have the strongest structure. A heterozygote would have one gene that is working a may produce enough of the protein to maintain the structure, but maybe not. So in some cases, just having one copy of the dominant (working) gene is enough. If it is a trait for something like eye color, this is not going to cause a defect, just a difference. In this case, being heterozygous or homozgyous for the dominant trait produces the same color of eye. In the case of sickle cell anemia, the recessive gene changes the protein structure of the shape of the red blood cell. If you have one good copy and one bad copy of the gene, some of your cells will be normal and some will be sickle cells. One good copy of the gene gives you enough normal red blood cells to stay healthy. But if you don't have a normal copy, all of your cells have the capability to sickle under certain conditions and this can be fatal. So think of dominant and recessive genes in terms of what they produce and what that protein is supposed to do and then think of what would happen if the dominant gene was able to overtake the effect of the recessive gene.

205

Prairie View A&M University Whole Campus Energy Analysis  

E-Print Network (OSTI)

-campus energy consumption at the Prairie View A&M Campus where whole-campus indices were developed that normalize for weather, conditioned area, and campus enrollment. The resultant indices were then used to estimate whole-campus energy savings resulting from.... This analysis develops indices that are normalized for weather, conditioned area, and campus enrollment. The resultant indices are then used to estimate energy savings from a guaranteed-savings contract at the Prairie View A&M Campus. j The next section...

Haberl, J. S.; Claridge, D. E.; Turner, W. D.

1991-01-01T23:59:59.000Z

206

Development of AeroView: an interactive flow diagnostics laboratory  

E-Print Network (OSTI)

simplify the academic experiments so that students can concentrate on the physics of the flow field while still being able to setup and control the experiment. To this end, an expandable interactive flow-diagnostics environment has been de- veloped... promt Fig. 2. Typical AeroView window. Extensive error checking is used to prevent system failures or equipment damage. The pro- gramming language used to create AeroView was Turbo Pascal 7. 0 with external sections written in Microsoft Quick BASIC 4...

Galls, Samuel Fernando

2012-06-07T23:59:59.000Z

207

Long Terminal Repeat Regions from Exogenous but Not Endogenous Feline Leukemia Viruses Transactivate Cellular Gene Expression  

Science Journals Connector (OSTI)

...nearly full-length endogenous FeLV molecular clones (CFE-6 and CFE-16) nor their isolated LTRs were able to activate collagenase...BALB/3T3 cells transiently transfected with isolated CFE-6 LTR, in contrast to transfections with LTRs from...

Sajal K. Ghosh; Pradip Roy-Burman; Douglas V. Faller

2000-10-01T23:59:59.000Z

208

Two Views of the Theory of Rough Sets in Finite Universes  

E-Print Network (OSTI)

Two Views of the Theory of Rough Sets in Finite Universes Y.Y. Yao 1 Department of Computer Science This paper presents and compares two views of the theory of rough sets. The operator-oriented view interprets rough set theory as an extension of set theory with two additional unary operators. Under such a view

Yao, Yiyu

209

3D-Model view characterization using equilibrium planes Adrien Theetten1  

E-Print Network (OSTI)

3D-Model view characterization using equilibrium planes Adrien Theetten1 , Tarik Filali Ansary1 to characteristic views. Abstract We propose a new method for 3D-mesh model charac- teristic view selection. It consists in using the views that come from the equilibrium states of a 3D-model: they cor- respond

Paris-Sud XI, Université de

210

Dynamic View Dependent Isosurface Extraction Yarden Livnat, Charles Hansen  

E-Print Network (OSTI)

-004 Scientific Computing and Imaging Institute University of Utah Salt Lake City, UT 84112 USA Enter date here1 Dynamic View Dependent Isosurface Extraction Yarden Livnat, Charles Hansen UUSCI-2003 Extraction Yarden Livnat Charles Hansen Scientific Computing and Imaging Institute School of Computing

Livnat, Yarden

211

An NTU Cooperative Game Theoretic View of Manipulating Elections  

E-Print Network (OSTI)

An NTU Cooperative Game Theoretic View of Manipulating Elections Michael Zuckerman1 , Piotr 27708, USA. conitzer@cs.duke.edu Abstract. Social choice theory and cooperative (coalitional) game, we use cooperative game theory tools in order to explore the coali- tion formation process

Rosenschein, Jeff

212

Foams As Viewed by Small-Angle Neutron Scattering  

Science Journals Connector (OSTI)

Foams As Viewed by Small-Angle Neutron Scattering ... For wet foams, we met other difficulties, common to any strongly scattering system:? a part of the scattered beam is collected in the central cells along with the transmitted beam; this can spoil the transmission measurements. ...

Monique A. V. Axelos; François Boué

2003-07-04T23:59:59.000Z

213

Formal Methods Technology Transfer: A View from NASA  

E-Print Network (OSTI)

Formal Methods Technology Transfer: A View from NASA James L. Caldwell Flight Electronics Home Page on the World­Wide Web 1 . In this paper I remark on the technology transfer strategy and its Formal Methods Home Page on the World­Wide Web. In this paper we concentrate on aspects of technology

Caldwell, James

214

NEWS & VIEWS nEutRon StaRS  

E-Print Network (OSTI)

NEWS & VIEWS nEutRon StaRS a magnetar by another name Fernando Camilo is at the Columbia core, held stable by neutron degeneracy pressure -- with more mass than the Sun within a 10 km radius -- has central densities comparable to those of nuclei. What does the neutron star sky look like, made

Loss, Daniel

215

Multiple Field of View MR Fluoroscopy Pelin Aksit,1  

E-Print Network (OSTI)

Multiple Field of View MR Fluoroscopy Pelin Aksit,1 J. Andrew Derbyshire,2 Jean-Michel Serfaty,1 by several investigators (1� 8). Intravascular MR compares favorably with other clini- cal diagnostic methods and Ergin Atalar1* This work describes a real-time imaging and visualization tech- nique that allows

Atalar, Ergin

216

A New Ontological View of the Quantum Measurement Problem  

E-Print Network (OSTI)

A new ontological view of the quantum measurement processes is given, which has bearings on many broader issues in the foundations of quantum mechanics as well. In this scenario a quantum measurement is a non-equilibrium phase transition in a ``resonant cavity'' formed by the entire physical universe including all of its material and energy content. A quantum measurement involves the energy and matter exchange among not only the system being measured and the measuring apparatus but also the global environment of the universe resonant cavity, which together constrain the nature of the phase transition. Strict realism, including strict energy and angular momentum conservation, is recovered in this view of the quantum measurement process beyond the limit set by the uncertainty relations, which are themselves derived from the exact commutation relations for quantum conjugate variables. Both the amplitude and the phase of the quantum mechanical wavefunction acquire substantial meanings in the new ontology, and the probabilistic element is removed from the foundations of quantum mechanics, its apparent presence in the quantum measurement being solely a result of the sensitive dependence on initial/boundary conditions of the phase transitions of a many degree-of-freedom system which is effectively the whole universe. Vacuum fluctuations are viewed as the ``left over'' fluctuations after forming the whole numbers of nonequilibrium resonant modes in the universe cavity. This new view on the quantum processes helps to clarify many puzzles in the foundations of quantum mechanics.

Xiaolei Zhang

2005-06-13T23:59:59.000Z

217

Project Management vs. Systems Engineering Management: A Practitioners' View on  

E-Print Network (OSTI)

Project Management vs. Systems Engineering Management: A Practitioners' View on IntegratingPROJECT MANAGEMENT VS. SYSTEMS ENGINEERING MANAGEMENT Received 3 August 2010; Revised 18 December 2010 (wileyonlinelibrary.com). DOI 10.1002/sys.20187 ABSTRACT While most Systems Engineering Management (SEM) applications

de Weck, Olivier L.

218

Multi-Disciplinary Views for Integrated and Concurrent Design  

E-Print Network (OSTI)

Multi-Disciplinary Views for Integrated and Concurrent Design R W AMOR and J G HOSKING e-mail: john and the level of information required. Used with a system that integrates various design tools through a computer based building model, this system will offer users information from a range of design tools

Amor, Robert

219

ROUGH SET APPROXIMATIONS: A CONCEPT ANALYSIS POINT OF VIEW  

E-Print Network (OSTI)

ROUGH SET APPROXIMATIONS: A CONCEPT ANALYSIS POINT OF VIEW Yiyu Yao University of Regina, Regina and content of data, definable concepts, lower and upper ap- proximations, rough set approximations Contents 1. Conclusion Bibliography Biographical Sketches Summary Rough set theory was proposed by Pawlak for analyzing

Yao, Yiyu

220

news and views A key issue for hydrogen storage materi-  

E-Print Network (OSTI)

news and views A key issue for hydrogen storage materi- als is that the hydrogenation and dehydro be possible to discover stable hydrogen hydrates with higher storage Hydrogen Posture Plan www.eere.energy.gov/hydrogenandfuelcells/pdfs/ hydrogen_posture_plan.pdf 7. Kuhs, W

Palumbi, Stephen

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


221

How species interact Altering the Standard View on Trophic Ecology  

E-Print Network (OSTI)

How species interact Altering the Standard View on Trophic Ecology Roger Arditi and Lev R. Ginzburg, the French National Institute for Agricultural Research, in the research unit of Ecology and Evolution of ecology and evolution at Stony Brook University since 1977. He has published widely on theoretical

Canet, Léonie

222

Geometric Tomography: A Limited-View Approach for Computed Tomography  

E-Print Network (OSTI)

Geometric Tomography: A Limited-View Approach for Computed Tomography Peter B. Noël, Jinhui Xu Keywords Computed Tomography; Geometric Compressed Sensing; Topo- logical Peeling. ABSTRACT Computed to generate 3D data, denoted f, directly from projec- tions, denoted g. Thus, the projection relationship can

Corso, Jason J.

223

View Consistency in Architectures for Cyber-Physical Systems  

Science Journals Connector (OSTI)

Current methods for modeling, analysis, and design of cyber-physical systems lack a unifying framework due to the complexity and heterogeneity of the constituent elements and their interactions. Our approach is to define relationships between system ... Keywords: system architecture, view consistency, graph morphism, multi-domain modeling, cyber-physical systems

Ajinkya Bhave; Bruce H. Krogh; David Garlan; Bradley Schmerl

2011-04-01T23:59:59.000Z

224

In all cases, ALOX5AP and its synonyms were highlighted automati-cally in each view. To highlight disease terms in these views, we  

E-Print Network (OSTI)

the results easy to explore. The novo|seek search box interface allows the user to enter a term (or the production of substances that cause inflammation, such as leukotrienes1. When we entered ALOX5AP as a search a simple view (title, journal and author), a snippet view (a simple view and the search term with flanking

Cai, Long

225

The Honorable Gene Dean  

Office of Legacy Management (LM)

Energy' .' Energy' .' Washington, DC 20585 DE! 14 1gg4 The Honorable Gene Dean \ P.O. Box 1659~ L Huntington, West Virginia 25717 _ ',.. : Dear Mayor Dean: Secretary of Energy Hazel O'Leary has'announced,a new approach ,to openness in the'Department of Energy (DOE) and its communications with the public. In support of this in.itiative, we are pleased,to forward the..enclosed information related to the former Reduction Pilot Plant sitein your jurisdiction that performed work for DOE predecessor agencies. This information is provided.for your information, use,.band retention., DDE's Formerly Utilized Sites Remedial.Action Program is responsible for identification of sitesused by DOE's predecessor agencies, determini,ng theirs current radiological condition and, where it has authority, performing

226

Viunalikeviruses are environmentally common agents of horizontal gene transfer in pathogens and biocontrol bacteria  

E-Print Network (OSTI)

and synthetic biology studies, but could be viewed as inappropriate choices for phage therapy. The ISME Journal advance online publication, 12 August 2014; doi:10.1038/ismej.2014.150 Combined morphological, genomic and phylogenetic analyses have recently led... ; Shahrbabak et al., 2013). Viunalikeviruses are characterised as virulent (lytic) phages showing similar genome size, extensive DNA homology, strong gene synteny and a complex adsorption apparatus, which uses tail spike proteins as host...

Matilla, M. A.; Fang, X.; Salmond, G. P. C.

2014-01-01T23:59:59.000Z

227

GenePRIMP: A GENE PRediction IMprovement Pipeline for Prokaryotic genomes  

SciTech Connect

We present 'gene prediction improvement pipeline' (GenePRIMP; http://geneprimp.jgi-psf.org/), a computational process that performs evidence-based evaluation of gene models in prokaryotic genomes and reports anomalies including inconsistent start sites, missed genes and split genes. We found that manual curation of gene models using the anomaly reports generated by GenePRIMP improved their quality, and demonstrate the applicability of GenePRIMP in improving finishing quality and comparing different genome-sequencing and annotation technologies.

Pati, Amrita; Ivanova, Natalia N.; Mikhailova, Natalia; Ovchinnikova, Galina; Hooper, Sean D.; Lykidis, Athanasios; Kyrpides, Nikos C.

2010-04-01T23:59:59.000Z

228

Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-{alpha}-positive human cells  

SciTech Connect

Bisphenol-A (BPA) shows proliferative actions in uterus and mammary glands and may influence the development of male and female reproductive tracts in utero or during early postnatal life. Because of its ability to function as an estrogen receptor (ER) agonist, BPA has the potential to disrupt normal endocrine signaling through regulation of ER target genes. Some genes are regulated by both estradiol (E2) and BPA, but those exclusive to either agent have not been described. Using a yeast strain incorporating a vitellogenin A2 ERE-LacZ reporter gene into the genome, we found that BPA induced expression of the reporter in colonies transformed with the ER{alpha} expression plasmid, illustrating BPA-mediated regulation within a chromatin context. Additionally, a reporter gene transiently transfected into the endometrial cancer (Ishikawa) cell line also showed BPA activity, although at 100-fold less potency than E2. To compare global gene expression in response to BPA and E2, we used a variant of the MCF-7 breast cancer cell line stably expressing HA-tagged ER{alpha}. Cultures were treated for 3 h with an ethanol vehicle, E2 (10{sup -8} M), or BPA (10{sup -6} M), followed by isolation of RNA and microarray analysis with the human U95A probe array (Affymetrix, Santa Clara, CA, USA). More than 300 genes were changed 2-fold or more by either or both agents, with roughly half being up-regulated and half down-regulated. A number of growth- and development-related genes, such as HOXC1 and C6, Wnt5A, Frizzled, TGF{beta}-2, and STAT inhibitor 2, were found to be affected exclusively by BPA. We used quantitative real-time PCR to verify regulation of the HOXC6 gene, which showed decreased expression of approximately 2.5-fold by BPA. These results reveal novel effects by BPA and E2, raising interesting possibilities regarding the role of endocrine disruptors in sexual development.

Singleton, David W. [Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267-0521 (United States); Feng, Yuxin [Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267-0521 (United States); Yang, Jun [Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267-0521 (United States); Puga, Alvaro [Department of Environmental Health, University of Cincinnati, Cincinnati, OH (United States); Lee, Adrian V. [Baylor College of Medicine, Houston, TX (United States); Khan, Sohaib A. [Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, University of Cincinnati, 3125 Eden Avenue, Cincinnati, OH 45267-0521 (United States)]. E-mail: sohaib.khan@uc.edu

2006-01-15T23:59:59.000Z

229

Mapping of the vaccinia virus DNA polymerase gene by marker rescue and cell-free translation of selected RNA  

SciTech Connect

The previous demonstration that a phosphonoacetate (PAA)-resistant (PAA/sup r/) vaccinia virus mutant synthesized an altered DNA polymerase provided the key to mapping this gene. Marker rescue was performed in cells infected with wild-type PAA-sensitive (PAA/sup s/) vaccinia by transfecting with calcium phosphate-precipitated DNA from a PAA/sup r/ mutant virus. Formation of PAA/sup r/ recombinants was measured by plaque assay in the presence of PAA. Of the 12 HindIII fragments cloned in plasmid or cosmid vectors, only fragment E conferred the PAA/sup r/ phenotype. Successive subcloning of the 15-kilobase HindIII fragment E localized the marker within a 7.5-kilobase BamHI-HindIII fragment and then within a 2.9-kilobase EcoRI fragment. The location of the DNA polymerase gene, about 57 kilobases from the left end of the genome, was confirmed by cell-free translation of mRNA selected by hybridization to plasmids containing regions of PAA/sup r/ vaccinia DNA active in marker rescue. A 100,000-dalton polypeptide that comigrated with authentic DNA polymerase was synthesized. Correspondence of the in vitro translation product with purified vaccinia DNA polymerase was established by peptide mapping.

Jones, E.V.; Moss, B.

1984-01-01T23:59:59.000Z

230

September 2013 Most Viewed Documents for Energy Storage, Conversion, And  

Office of Scientific and Technical Information (OSTI)

September 2013 Most Viewed Documents for Energy Storage, Conversion, And September 2013 Most Viewed Documents for Energy Storage, Conversion, And Utilization Process Equipment Cost Estimation, Final Report H.P. Loh; Jennifer Lyons; Charles W. White, III (2002) 169 Evaluation of the 2010 Toyota Prius Hybrid Synergy Drive System Burress, Timothy A [ORNL]; Campbell, Steven L [ORNL]; Coomer, Chester [ORNL]; Ayers, Curtis William [ORNL]; Wereszczak, Andrew A [ORNL]; Cunningham, Joseph Philip [ORNL]; Marlino, Laura D [ORNL]; Seiber, Larry Eugene [ORNL]; Lin, Hua-Tay [ORNL] (2011) 116 Evaluation of the 2007 Toyota Camry Hybrid Syneregy Drive System Burress, T.A.; Coomer, C.L.; Campbell, S.L.; Seiber, L.E.; Marlino, L.D.; Staunton, R.H.; Cunningham, J.P. (2008) 102 A study of lead-acid battery efficiency near top-of-charge and the impact on PV system design

231

Most Viewed Documents - Mathematics and Computing | OSTI, US Dept of  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - Mathematics and Computing Most Viewed Documents - Mathematics and Computing Metaphors for cyber security. Moore, Judy Hennessey; Parrott, Lori K.; Karas, Thomas H. (2008) Staggered-grid finite-difference acoustic modeling with the Time-Domain Atmospheric Acoustic Propagation Suite (TDAAPS). Aldridge, David Franklin; Collier, Sandra L. (U.S. Army Research Laboratory); Marlin, David H. (U.S. Army Research Laboratory); et al. (2005) Salinas : theory manual. Walsh, Timothy Francis; Reese, Garth M.; Bhardwaj, Manoj Kumar (2004) LANL Site Update Armstrong, Harold G [Los Alamos National Laboratory] (2012) Scientific Data Management Integrated Software Infrastructure Center (SDM/ISIC): Scientific Process Automation (SPA), FINAL REPORT Bertram Ludaescher; Ilkay Altintas (2012) HPC Utilities

232

East Pleasant View, Colorado: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

View, Colorado: Energy Resources View, Colorado: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 39.7276261°, -105.1573284° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":39.7276261,"lon":-105.1573284,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

233

April 2013 Most Viewed Documents for Energy Storage, Conversion, And  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Energy Storage, Conversion, And April 2013 Most Viewed Documents for Energy Storage, Conversion, And Utilization Seventh Edition Fuel Cell Handbook NETL (2004) 628 Continuously variable transmissions: theory and practice Beachley, N.H.; Frank, A.A. (null) 205 A study of lead-acid battery efficiency near top-of-charge and the impact on PV system design Stevens, J.W.; Corey, G.P. (1996) 173 Energy Saving Potentials and Air Quality Benefits of Urban HeatIslandMitigation Akbari, Hashem (2005) 153 Building a secondary containment system Broder, M.F. (1994) 144 An Improved Method of Manufacturing Corrugated Boxes: Lateral Corrugator Frank C. Murray Ph.D.; , Roman Popil Ph.D.; Michael Shaepe (formerly with IPST, now at Cargill. Inc) (2008) 141 Ammonia usage in vapor compression for refrigeration and air-conditioning in the United States

234

Most Viewed Documents - Energy Storage, Conversion, and Utilization | OSTI,  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - Energy Storage, Conversion, and Utilization Most Viewed Documents - Energy Storage, Conversion, and Utilization Process Equipment Cost Estimation, Final Report H.P. Loh; Jennifer Lyons; Charles W. White, III (2002) Continuously variable transmissions: theory and practice Beachley, N.H.; Frank, A.A. () Review of air flow measurement techniques McWilliams, Jennifer (2002) Building a secondary containment system Broder, M.F. (1994) Cost benefit analysis of the night-time ventilative cooling in office building Seppanen, Olli; Fisk, William J.; Faulkner, David (2003) Evaluation of the 2007 Toyota Camry Hybrid Syneregy Drive System Burress, T.A.; Coomer, C.L.; Campbell, S.L.; et al. (2008) Nanofluid technology : current status and future research. Choi, S. U.-S. (1998) An Improved Method of Manufacturing Corrugated Boxes: Lateral

235

Most Viewed Documents - Power Generation and Distribution | OSTI, US Dept  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - Power Generation and Distribution Most Viewed Documents - Power Generation and Distribution Electric power high-voltage transmission lines: Design options, cost, and electric and magnetic field levels Stoffel, J.B.; Pentecost, E.D.; Roman, R.D.; et al. (1994) ASPEN Plus Simulation of CO2 Recovery Process Charles W. White III (2003) Systems and economic analysis of microalgae ponds for conversion of CO{sub 2} to biomass. Quarterly technical progress report, September 1993--December 1993 Benemann, J.R.; Oswald, W.J. (1994) Load flow analysis: Base cases, data, diagrams, and results Portante, E.C.; Kavicky, J.A.; VanKuiken, J.C.; et al. (1997) Multilevel converters -- A new breed of power converters Lai, J.S. [Oak Ridge National Lab., TN (United States). Engineering Technology Div.]; Peng, F.Z. [Univ. of Tennessee, Knoxville, TN (United

236

National Library of Energy : Main View : Deep Federated Search  

Office of Scientific and Technical Information (OSTI)

National Library of Energy National Library of Energy Search Powered By Deep Web Technologies Modify Search Preferences Powered by Deep Web Technologies HOME About NLE Communications FAQs Help Site Map Feedback/Contact Us Main View This view is used for searching all possible sources. SEARCH OPTIONS Additional Information Keyword: Title: Additional Information Author: Fields to Match: All Any Field(s) Additional Information Date Range: Beginning Date Range Pick Year 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 toEnding Date Range Pick Year 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 Search Clear All Help Simple Search Expand Category All Sources

237

Most Viewed Documents - Environmental Sciences | OSTI, US Dept of Energy,  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - Environmental Sciences Most Viewed Documents - Environmental Sciences Separation of heavy metals: Removal from industrial wastewaters and contaminated soil Peters, R.W.; Shem, L. (1993) Special Report on Emissions Scenarios : a special report of Working Group III of the Intergovernmental Panel on Climate Change Nakicenovic, Nebojsa; Alcamo, Joseph; Davis, Gerald; et al. (2000) CARBON DIOXIDE (REDUCTION) FUJITA,E. (2000) Ecological Screening Values for Surface Water, Sediment, and Soil Friday, G. P. (1999) Mitigation options for accidental releases of hazardous gases Fthenakis, V.M. (1995) Atmospheric Chemistry and Greenhouse Gases Ehhalt, D.; Prather, M.; Dentener, F.; et al. (2001) Ammonia usage in vapor compression for refrigeration and air-conditioning in the United States Fairchild, P.D.; Baxter, V.D. (1995)

238

April 2013 Most Viewed Documents for Fission And Nuclear Technologies |  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Fission And Nuclear Technologies April 2013 Most Viewed Documents for Fission And Nuclear Technologies Behavior of spent nuclear fuel in water pool storage Johnson, A.B. Jr. (null) 298 Estimation of gas leak rates through very small orifices and channels. [From sealed PuO/sub 2/ containers under accident conditions] Bomelburg, H.J. (null) 292 Graphite design handbook Ho, F.H. (1988) 216 System Definition and Analysis: Power Plant Design and Layout NONE (1996) 123 Flow-induced vibration of circular cylindrical structures Chen, S.S. (1985) 116 Stress analysis and evaluation of a rectangular pressure vessel. [For equipment for sampling Hanford tank radwaste] Rezvani, M.A.; Ziada, H.H. (Westinghouse Hanford Co., Richland, WA (United States)); Shurrab, M.S. (Westinghouse Savannah River Co., Aiken, SC (United

239

Mountain View Elec Assn, Inc | Open Energy Information  

Open Energy Info (EERE)

Mountain View Elec Assn, Inc Mountain View Elec Assn, Inc Place Colorado Utility Id 13058 Utility Location Yes Ownership C NERC Location WECC NERC WECC Yes Activity Distribution Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png 16.01 RESIDENTIAL RATE Residential 16.05 RESIDENTIAL TIME OF DAY SERVICE RATE Residential 18.40 SMALL POWER RATE Commercial 18.60 LARGE POWER RATE Commercial 18.61 LARGE POWER - PRIMARY METERING RATE Commercial 18.62 LARGE POWER - LOAD MANAGEMENT RATE Commercial 18.63 LARGE POWER - LOAD MANAGEMENT - PRIMARY METERING RATE Commercial 18.64 GENERAL POWER RATE Industrial

240

April 2013 Most Viewed Documents for Power Generation And Distribution |  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Power Generation And Distribution April 2013 Most Viewed Documents for Power Generation And Distribution Electric power high-voltage transmission lines: Design options, cost, and electric and magnetic field levels Stoffel, J.B.; Pentecost, E.D.; Roman, R.D.; Traczyk, P.A. (1994) 719 Seventh Edition Fuel Cell Handbook NETL (2004) 628 ASPEN Plus Simulation of CO2 Recovery Process Charles W. White III (2003) 343 Wet cooling towers: rule-of-thumb design and simulation Leeper, S.A. (1981) 290 Load flow analysis: Base cases, data, diagrams, and results Portante, E.C.; Kavicky, J.A.; VanKuiken, J.C.; Peerenboom, J.P. (1997) 248 Controlled low strength materials (CLSM), reported by ACI Committee 229 Rajendran, N. (1997) 106 Micro-CHP Systems for Residential Applications Timothy DeValve; Benoit Olsommer (2007)

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


241

The Collagen Protein Viewed at Unprecedented Detail | Advanced Photon  

NLE Websites -- All DOE Office Websites (Extended Search)

Assembling Nanoparticles the Easy DNA-Way Assembling Nanoparticles the Easy DNA-Way Better, cleaner fuel injectors for automobiles? Poxvirus Potency Uncovered in New Atomic Map Striking Nano Gold Oldest Known Magnet's Secrets Revealed Under High Pressures Science Highlights Archives: 2013 | 2012 | 2011 | 2010 2009 | 2008 | 2007 | 2006 2005 | 2004 | 2003 | 2002 2001 | 2000 | 1998 | Subscribe to APS Science Highlights rss feed The Collagen Protein Viewed at Unprecedented Detail FEBRUARY 26, 2008 Bookmark and Share A view of a rat tail tendon using second-harmonic generation microscopy. The collagen fibers show up in green and red. The structure and behavior of one of the most common proteins in our bodies has been resolved at a level of detail never before seen, thanks to new research performed at the Advanced Photon Source (APS) at the U.S.

242

City View, South Carolina: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

View, South Carolina: Energy Resources View, South Carolina: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 34.8615064°, -82.4315121° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":34.8615064,"lon":-82.4315121,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

243

E-print Network : Main View : Deep Federated Search  

Office of Scientific and Technical Information (OSTI)

E-print Network E-print Network Search Powered By Deep Web Technologies New Search Preferences E-print Network E-print Network Skip to main content FAQ * HELP * SITE MAP * CONTACT US Home * About * Advanced Search * Browse by Discipline * Scientific Societies * E-print Alerts * Add E-prints Powered by Deep Web Technologies E-print Network E-print Network Skip to main content FAQ * HELP * SITE MAP * CONTACT US Home * About * Advanced Search * Browse by Discipline * Scientific Societies * E-print Alerts * Add E-prints Main View This view is used for searching all possible sources. Due to the varied configuration and diversity of web pages and databases searched by E-prints, Full Record will search whatever data is searchable at each site. Multiple arXiv sites under one general heading are combined

244

Metrology/viewing system for next generation fusion reactors  

SciTech Connect

Next generation fusion reactors require accurate measuring systems to verify sub-millimeter alignment of plasma-facing components in the reactor vessel. A metrology system capable of achieving such accuracy must be compatible with the vessel environment of high gamma radiation, high vacuum, elevated temperature, and magnetic field. This environment requires that the system must be remotely deployed. A coherent, frequency modulated laser radar system is being integrated with a remotely operated deployment system to meet these requirements. The metrology/viewing system consists of a compact laser transceiver optics module which is linked through fiber optics to the laser source and imaging units that are located outside of the harsh environment. The deployment mechanism is a telescopic-mast positioning system. This paper identifies the requirements for the International Thermonuclear Experimental Reactor metrology and viewing system, and describes a remotely operated precision ranging and surface mapping system.

Spampinato, P.T.; Barry, R.E.; Chesser, J.B.; Menon, M.M. [Oak Ridge National Lab., TN (United States); Dagher, M.A. [Boeing Rocketdyne Div., Canoga Park, CA (United States)

1997-02-01T23:59:59.000Z

245

Narrow Field of View Zenith Radiometer (NFOV) Handbook  

SciTech Connect

The two-channel narrow field-of-view radiometer (NFOV2) is a ground-based radiometer that looks straight up and measures radiance directly above the instrument at wavelengths of 673 and 870 nm. The field-of-view of the instrument is 1.2 degrees, and the sampling time resolution is one second. Measurements of the NFOV2 have been used to retrieve optical properties for overhead clouds that range from patchy to overcast. With a one-second sampling rate of the NFOV2, faster than almost any other ARM Climate Research Facility (ACRF) instrument, we are able, for the first time, to capture changes in cloud optical properties at the natural time scale of cloud evolution.

Chiu, C; Marshak, A; Hodges, G; Barnard, JC; Schmelzer, J

2008-11-01T23:59:59.000Z

246

EM SSAB Contributes Community Views to Clean-up Decisions  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Contributes Community Views to Clean-up Decisions Contributes Community Views to Clean-up Decisions 2011 Local Board Contributions The Environmental Management Site-Specific Advisory Board (EM SSAB) has a unique mandate to provide input regarding the cleanup of nuclear legacy sites to the Department of Energy's Office of Environmental Management (EM). Chartered under the Federal Advisory Committee Act, the EM SSAB today comprises eight local boards, located in Hanford, WA; Idaho Falls, ID: Los Alamos, NM; the Nevada National Security Site; Oak Ridge, TN; Paducah, KY; Portsmouth, OH; and the Savannah River Site, SC. EM has made public participation a fundamental component of its cleanup mission and has found that the EM SSAB, which draws upon diverse community

247

Finite element training before real analysis: A personal view  

Science Journals Connector (OSTI)

In finite element structural analysis, we have the dilemma that an engineer can solve a very complex problem using multi-million dollar software on high-technology hardware with beautifully coloured pictures of the results, without knowing the fundamentals of the finite element method. In this paper the author presents a personal view of how this dilemma should be resolved. His solution emphasises the crucial importance of standards, quality assurance, reliability and, above all, education and training in finite element analysis.

John Robinson

1994-01-01T23:59:59.000Z

248

Relativism and views in a conceptual data base model  

SciTech Connect

In a core schema that attempted to faithfully represent the inter-connectedness of the real world, each class role would need to be made explicit, naming its respectively associated classes and mappings. From each role a characteristic family of derived views can be inferred. In practice, this program need not be fully carried out as there are always connections in the real world which we choose not to model. But it is interesting to imagine an information system that behaved as if all (or at least all obvious) possible views had been automatically defined. It appears that humans have a system for doing some such automatic schema transformation in our natural semantic model of the world. As we constantly shift perspectives we seem always to be able to readily call up whatever role is appropriate for any given object in (mental) view. The work described falls in an area that is just on the edge of currently developing DB technologies. It is motivated by a desire to achieve systems that are more natural, more intelligent, and which better complement and support our own intellectual activity in the management and modelling of complex environments. There are, of course, many issues involved here which are far from the arena of cognitive science (especially the more purely technical issues of physical system implementation.) But there are many aspects of the interface toward which these efforts are aimed which remain open questions that AI and cognitive science in general can help to clarify.

Kreps, P.

1980-04-01T23:59:59.000Z

249

Gene encoding herbicide safener binding protein  

DOE Patents (OSTI)

The cDNA encoding safener binding protein (SafBP), also referred to as SBP1, is set forth in FIG. 5 and SEQ ID No. 1. The deduced amino acid sequence is provided in FIG. 5 and SEQ ID No. 2. Methods of making and using SBP1 and SafBP to alter a plant's sensitivity to certain herbicides or a plant's responsiveness to certain safeners are also provided, as well as expression vectors, transgenic plants or other organisms transfected with said vectors and seeds from said plants.

Walton, Jonathan D. (East Lansing, MI); Scott-Craig, John S. (East Lansing, MI)

1999-01-01T23:59:59.000Z

250

Viewing the Larger Context of Genomic Data through Horizontal Integration  

E-Print Network (OSTI)

, and reveals the root causes of cancer. One of the most powerful new tools molecular biologists wield to solve visualization techniques[1, 2]. Gene expression microarrays simultaneously measure the activation or suppression tools to mine these data to discover new biological information. Biologists face the challenges

Dunham, Maitreya

251

Prodigal: Microbial Gene Prediction Software  

NLE Websites -- All DOE Office Websites (Extended Search)

Screenshot Screenshot Artemis Screenshot of Prodigal Results Compared with Curated Annotations and other Computational Genefinders for Anaeromyxobacter dehalogenans 2CP-C (Click to enlarge) Prodigal (Prokaryotic Dynamic Programming Genefinding Algorithm) is a microbial (bacterial and archaeal) gene finding program developed at Oak Ridge National Laboratory and the University of Tennessee. Key features of Prodigal include: Speed: Prodigal is an extremely fast gene recognition tool (written in very vanilla C). It can analyze an entire microbial genome in 30 seconds or less. Accuracy: Prodigal is a highly accurate gene finder. It correctly locates the 3' end of every gene in the experimentally verified Ecogene data set (except those containing introns). It possesses a very

252

Whose genes can stomach cancer?  

Science Journals Connector (OSTI)

... a person develops stomach cancer depends partly on their genes, new research suggests. As John Whitfield reports, this discovery could help prevent the disease. El-Omar,E. M. ...

John Whitfield

2000-03-23T23:59:59.000Z

253

Ethics of Gene Therapy Debated  

Science Journals Connector (OSTI)

Ethics of Gene Therapy Debated ... A press conference at the annual meeting of the American Association for the Advancement of Science in Washington, D.C., last month turned into an impromptu debate on the ethical and policy implications of human gene therapy. ... The protagonists were biomedical ethicist LeRoy Walters of Georgetown University, and attorney Andrew Kimbrell of the Foundation on Economic Trends, an activist group that has filed many lawsuits relating to biotechnology. ...

STU BORMAN

1991-03-04T23:59:59.000Z

254

Fusion genes in breast cancer  

E-Print Network (OSTI)

Fusion genes in breast cancer Elizabeth M. Batty Clare College, University of Cambridge A dissertation submitted to the University of Cambridge in candidature for the degree of Doctor of Philosophy November 2010 ii... is the outcome of work done in collaboration except where specifically indicated in the text. It has not been submitted whole or in part for any other qualification at any other University. iii Summary Fusion genes in breast cancer Elizabeth Batty...

Batty, Elizabeth

2012-02-07T23:59:59.000Z

255

Vehicle Technologies Office: Fact #416: March 20, 2006 Consumer Views on  

NLE Websites -- All DOE Office Websites (Extended Search)

6: March 20, 6: March 20, 2006 Consumer Views on Gasoline Taxes to someone by E-mail Share Vehicle Technologies Office: Fact #416: March 20, 2006 Consumer Views on Gasoline Taxes on Facebook Tweet about Vehicle Technologies Office: Fact #416: March 20, 2006 Consumer Views on Gasoline Taxes on Twitter Bookmark Vehicle Technologies Office: Fact #416: March 20, 2006 Consumer Views on Gasoline Taxes on Google Bookmark Vehicle Technologies Office: Fact #416: March 20, 2006 Consumer Views on Gasoline Taxes on Delicious Rank Vehicle Technologies Office: Fact #416: March 20, 2006 Consumer Views on Gasoline Taxes on Digg Find More places to share Vehicle Technologies Office: Fact #416: March 20, 2006 Consumer Views on Gasoline Taxes on AddThis.com... Fact #416: March 20, 2006 Consumer Views on Gasoline Taxes

256

DOE Zero Energy Ready Home Case Study, Clifton View Homes, Coupeville...  

Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

Study, Clifton View Homes, Coupeville, WA, Systems Home DOE Zero Energy Ready Home Case Study, Clifton View Homes, Coupeville, WA, Systems Home Case-study of a DOE Zero Energy...

257

DOE Zero Energy Ready Home Case Study: Clifton View Homes, Whidbey...  

Energy Savers (EERE)

Study: Clifton View Homes, Whidbey Island, WA DOE Zero Energy Ready Home Case Study: Clifton View Homes, Whidbey Island, WA Case study of a DOE Zero Energy Ready home on Whidbey...

258

Bunker View: Limited-range head-motion-parallax visualization for complex data sets  

E-Print Network (OSTI)

Bunker View: Limited-range head-motion-parallax visualization for complex data sets Andrei State tracking. #12;3. THE BUNKER VIEW SYSTEM We propose to use image precomputation to avoid high lag and low

State, Andrei

259

Getting Started with ParaView for DOE Facility Users | Argonne...  

NLE Websites -- All DOE Office Websites (Extended Search)

ParaView for DOE Facility Users Interactive Training: Getting Started with ParaView for DOE Users November 5, 2014 REGISTER HERE Join us for a two-hour, interactive...

260

Nepal: Western Views of the Maoist Insurgency and the Royal Takeover  

E-Print Network (OSTI)

Governance Presentation No. 2 Nepal: Western Views of theworkingpapers/index.html NEPAL: Western Views of the Maoistof the Maoist revolt in Nepal in 1996, there have been a

Burleigh, Peter

2005-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


261

The need for a human gene index  

Science Journals Connector (OSTI)

......need for a human gene index. | Editorial | Abstracting...NEED FOR A HUMAN GENE INDEX Much noise has been made...the year 2000 about the completion of a "draft" of the...changes in assembly and completion of the draft genome...need for a human gene index Towards a true gene index......

C. Victor Jongeneel

2000-12-01T23:59:59.000Z

262

California’s Energy Future: The View to 2050 - Summary Report  

E-Print Network (OSTI)

Energy Future - The View to 2050 Bin Biofuel Technology Hydrogen Ethanol from sugar and starch (e.g. , corn,

Yang, Christopher

2011-01-01T23:59:59.000Z

263

Recombinant HT.sub.m4 gene, protein and assays  

DOE Patents (OSTI)

The invention relates to a recombinant DNA molecule which encodes a HT.sub.m4 protein, a transformed host cell which has been stably transfected with a DNA molecule which encodes a HT.sub.m4 protein and a recombinant HT.sub.m4 protein. The invention also relates to a method for detecting the presence of a hereditary atopy.

Lim, Bing (Dorcester, MA); Adra, Chaker N. (Boston, MA); Lelias, Jean-Michel (Toulouse, FR)

1996-01-01T23:59:59.000Z

264

Transport mechanisms acting in toroidal devices: A theoretician's view  

SciTech Connect

Understanding the basic mechanisms of transport in toroidal confinement devices remains one of the more challenging scientific issues in magnetic confinement. At the same time, it is a critical issue for the magnetic fusion program. Recent progress in understanding fluctuations and transport has been fostered by the development and use of new diagnostics, bringing new perspectives on these studies. This has stimulated new theoretical developments. A view of the most recent issues and progress in this area is given. The role of long wavelengths in core transport and the relation between shear flows and turbulence at the plasma edge are the primary topics considered.

Carreras, B.A.

1993-01-01T23:59:59.000Z

265

GenomeView: a next-generation genome browser Thomas Abeel1,2,3,  

E-Print Network (OSTI)

GenomeView: a next-generation genome browser Thomas Abeel1,2,3, *, Thomas Van Parys1,2 , Yvan Saeys GenomeView, a stand-alone genome browser specifically designed to visualize and manipulate a multitude of genomics data. GenomeView enables users to dynamically browse high volumes of aligned short-read data

Gent, Universiteit

266

The Implementation of Mobile Bank Usage from marketing point of view of bank managers in Jordan.  

E-Print Network (OSTI)

The Implementation of Mobile Bank Usage from marketing point of view of bank managers in Jordan of view in Jordan on the different dimensions of the study (Gender of bank managers, Age of bank managers between the Implementation of Mobile Bank Usage from marketing point of view of bank managers in Jordan

267

TOURISM PRODUCT DEVELOPMENT: A CASE STUDY OF WILDLIFE VIEWING IN THE SQUAMISH  

E-Print Network (OSTI)

TOURISM PRODUCT DEVELOPMENT: A CASE STUDY OF WILDLIFE VIEWING IN THE SQUAMISH VALLEY by Kim Cherie: Tourism Product Development: A Case Study of Wildlife Viewing In the Squamish Valley PROJECT: 284 #12;iii ABSTRACT Wildlife viewing is an increasingly important form of tourism in British Columbia

268

Integrated Network Analysis Identifies Fight-Club Nodes as a Class of Hubs Encompassing Key Putative Switch Genes That Induce Major Transcriptome Reprogramming during Grapevine Development  

Science Journals Connector (OSTI)

...Pezzotti ( mario.pezzotti@univr.it ) and Paola Paci ( paola.paci@iasi.cnr.it ). [W] Online version contains Web-only data. [OPEN] Articles can be viewed online without a subscription. A small pool of putative switch genes, whose expression...

Maria Concetta Palumbo; Sara Zenoni; Marianna Fasoli; Mélanie Massonnet; Lorenzo Farina; Filippo Castiglione; Mario Pezzotti; Paola Paci

2014-12-09T23:59:59.000Z

269

Mountain View Power Partners I Wind Farm | Open Energy Information  

Open Energy Info (EERE)

I Wind Farm I Wind Farm Jump to: navigation, search Name Mountain View Power Partners I Wind Farm Facility Mountain View Power Partners I Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner MDU Resources Developer SeaWest Energy Purchaser L.A. Department of Water Resources Location San Gorgonio CA Coordinates 33.9095°, -116.734° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":33.9095,"lon":-116.734,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

270

A laser scanning system for metrology and viewing in ITER  

SciTech Connect

The construction and operation of a next-generation fusion reactor will require metrology to achieve and verify precise alignment of plasma-facing components and inspection in the reactor vessel. The system must be compatible with the vessel environment of high gamma radiation (10{sup 4} Gy/h), ultra-high-vacuum (10{sup {minus}8} torr), and elevated temperature (200 C). The high radiation requires that the system be remotely deployed. A coherent frequency modulated laser radar-based system will be integrated with a remotely operated deployment mechanism to meet these requirements. The metrology/viewing system consists of a compact laser transceiver optics module which is linked through fiber optics to the laser source and imaging units that are located outside of a biological shield. The deployment mechanism will be a mast-like positioning system. Radiation-damage tests will be conducted on critical sensor components at Oak Ridge National Laboratory to determine threshold damage levels and effects on data transmission. This paper identifies the requirements for International Thermonuclear Experimental Reactor metrology and viewing and describes a remotely operated precision ranging and surface mapping system.

Spampinato, P.T.; Barry, R.E.; Menon, M.M.; Herndon, J.N. [Oak Ridge National Lab., TN (United States); Dagher, M.A.; Maslakowski, J.E. [Rockwell Rocketdyne Div., Canoga Park, CA (United States)

1996-05-01T23:59:59.000Z

271

Gene encoding plant asparagine synthetase  

DOE Patents (OSTI)

The identification and cloning of the gene(s) for plant asparagine synthetase (AS), an important enzyme involved in the formation of asparagine, a major nitrogen transport compound of higher plants is described. Expression vectors constructed with the AS coding sequence may be utilized to produce plant AS; to engineer herbicide resistant plants, salt/drought tolerant plants or pathogen resistant plants; as a dominant selectable marker; or to select for novel herbicides or compounds useful as agents that synchronize plant cells in culture. The promoter for plant AS, which directs high levels of gene expression and is induced in an organ specific manner and by darkness, is also described. The AS promoter may be used to direct the expression of heterologous coding sequences in appropriate hosts.

Coruzzi, Gloria M. (New York, NY); Tsai, Fong-Ying (New York, NY)

1993-10-26T23:59:59.000Z

272

Using co-expression to redefine functional gene sets for gene set enrichment analysis  

E-Print Network (OSTI)

Manually curated gene sets related to a biological function often contain genes that are not tightly co-regulated transcriptionally. which obscures the evidence of coordinated differential expression of these gene sets in ...

Kodysh, Yuliya

2007-01-01T23:59:59.000Z

273

Vol. 18, No. 3, 2008, Nuclear Physics News 3 The views expressed here do not represent the views and policies of NuPECC except where explicitly identified.  

E-Print Network (OSTI)

editorial Vol. 18, No. 3, 2008, Nuclear Physics News 3 The views expressed here do not represent the views and policies of NuPECC except where explicitly identified. Editorial Advances in precision cosmol astonishing, has been the reinvention of nuclear theory. When I was a graduate student in the early 1980s

Washington at Seattle, University of - Department of Physics, Electroweak Interaction Research Group

274

ParaView on the Data Analytics Cluster on Eureka/Gadzooks | Argonne  

NLE Websites -- All DOE Office Websites (Extended Search)

on the Data Analytics Cluster on Eureka/Gadzooks on the Data Analytics Cluster on Eureka/Gadzooks Set Up User Environment The recommended way of running ParaView on Eureka is in client/server mode. This consists of running the ParaView client on your local resource, and the ParaView server (pvserver) on the Eureka visualization nodes. The latest version currently installed on Eureka is ParaView 4.0.1. This should first be installed on your local resource. Binary and source packages for Linux, MacOS, and Windows are available from the ParaView Download Page. (Run the 'softenv' command on the Eureka login node to see additional versions of ParaView that are available on Eureka). To put ParaView in your environment on Eureka, add the following line to your ~/.softenvrc file NOTE: This must go before the @default entry. Also note that this macro

275

T-538: HP OpenView Storage Data Protector Bug Lets Remote Users Execute  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

T-538: HP OpenView Storage Data Protector Bug Lets Remote Users T-538: HP OpenView Storage Data Protector Bug Lets Remote Users Execute Arbitrary Code T-538: HP OpenView Storage Data Protector Bug Lets Remote Users Execute Arbitrary Code January 20, 2011 - 6:39am Addthis PROBLEM: HP OpenView Storage Data Protector Bug Lets Remote Users Execute Arbitrary Code. PLATFORM: HP OpenView Storage Data Protector v6.11 ABSTRACT: A vulnerability was reported in HP OpenView Storage Data Protector. A remote user can execute arbitrary code on the target system. reference LINKS: HP Security Bulletin SecurityTracker Alert ID: 1024983 CVE-2011-0273 IMPACT ASSESSMENT: High Discussion: A potential security vulnerability has been identified with HP OpenView Storage Data Protector. The vulnerability could be remotely exploited to execute arbitrary code.

276

T-721:Mac OS X Directory Services Lets Local Users View User Password  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

21:Mac OS X Directory Services Lets Local Users View User 21:Mac OS X Directory Services Lets Local Users View User Password Hashes T-721:Mac OS X Directory Services Lets Local Users View User Password Hashes September 20, 2011 - 8:45am Addthis PROBLEM: Mac OS X Directory Services Lets Local Users View User Password Hashes. PLATFORM: Mac OS X Lion (10.7) ABSTRACT: A local user can view user password hashes. reference LINKS: SecurityTracker Alert ID: 1026067 Apple Support Downloads Apple Security Updates Apple OS X Lion v10.7.1 Update IMPACT ASSESSMENT: Medium Discussion: A vulnerability was reported in Mac OS X. A local user can view user password hashes. A local user can invoke the following Directory Services command line command to view the password hash for the target user: dscl localhost -read /Search/Users/[target user] A local user can change their

277

Helix Wind Inc formerly ClearView Acquisitions | Open Energy Information  

Open Energy Info (EERE)

Helix Wind Inc formerly ClearView Acquisitions Helix Wind Inc formerly ClearView Acquisitions Jump to: navigation, search Name Helix Wind Inc. (formerly ClearView Acquisitions) Place San Diego, California Zip 92113 Sector Wind energy Product California-based manufacturer of small scale wind turbines. References Helix Wind Inc. (formerly ClearView Acquisitions)[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Helix Wind Inc. (formerly ClearView Acquisitions) is a company located in San Diego, California . References ↑ "Helix Wind Inc. (formerly ClearView Acquisitions)" Retrieved from "http://en.openei.org/w/index.php?title=Helix_Wind_Inc_formerly_ClearView_Acquisitions&oldid=346471"

278

Gene 240 (1999) 4555 www.elsevier.com/locate/gene  

E-Print Network (OSTI)

gene of E. coli, which encodes an essentialtide(s); ORF, open reading frame; PAC, P1 artificial; Protein expression from ARD-1 cDNA in E. coli resultsSDS, sodium dodecyl sulfate; snRNP, small nuclear Abstract ARD-1 is an endoribonuclease identified initially as the product of a human cDNA that complements

Trinkle-Mulcahy, Laura

279

City of Lake View, Iowa (Utility Company) | Open Energy Information  

Open Energy Info (EERE)

Place Iowa Place Iowa Utility Id 10617 Utility Location Yes Ownership M NERC Location MRO NERC MRO Yes ISO MISO Yes Activity Buying Transmission Yes Activity Distribution Yes Activity Bundled Services Yes References EIA Form EIA-861 Final Data File for 2010 - File1_a[1] LinkedIn Connections CrunchBase Profile No CrunchBase profile. Create one now! This article is a stub. You can help OpenEI by expanding it. Utility Rate Schedules Grid-background.png Commercial Service Commercial Residential Service Residential Rural Service Residential Three-Phase Service Industrial Average Rates Residential: $0.0698/kWh Commercial: $0.0685/kWh Industrial: $0.0710/kWh References ↑ "EIA Form EIA-861 Final Data File for 2010 - File1_a" Retrieved from "http://en.openei.org/w/index.php?title=City_of_Lake_View,_Iowa_(Utility_Company)&oldid=409821

280

Mountain View Power Partners III Wind Farm | Open Energy Information  

Open Energy Info (EERE)

Power Partners III Wind Farm Power Partners III Wind Farm Facility Mountain View Power Partners III Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner PPM Energy Inc Developer PPM Energy Inc Energy Purchaser San Diego Gas & Electric Location San Gorgonio CA Coordinates 33.9095°, -116.734° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":33.9095,"lon":-116.734,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


281

National Synchrotron Light Source A View of Brookhaven  

NLE Websites -- All DOE Office Websites (Extended Search)

managed for the U.S. Department of Energy managed for the U.S. Department of Energy by Brookhaven Science Associates, a company founded by Stony Brook University and Battelle managed for the U.S. Department of Energy by Brookhaven Science Associates, a company founded by Stony Brook University and Battelle National Synchrotron Light Source A View of Brookhaven Brookhaven National Laboratory is a multipurpose re- search laboratory funded by the U.S. Department of En- ergy. Located on a 5,300-acre site on Long Island, New York, the Laboratory operates large-scale facilities for studies in physics, chemistry, biology, medicine, applied science, and advanced technology. Brookhaven's 2,600 scientists, engineers, and support staff are joined each year by more than 5,000 visiting research- ers from around the world.

282

Multi-view spectral clustering and its chemical application  

Science Journals Connector (OSTI)

Clustering is an unsupervised method that allows researchers to group objects and gather information about their relationships. In chemoinformatics, clustering enables hypotheses to be drawn about a compound's biological, chemical and physical property in comparison to another. We introduce a novel improved spectral clustering algorithm, proposed for chemical compound clustering, using multiple data sources. Tensor-based spectral methods, used in this paper, provide chemically appropriate and statistically significant results when attempting to cluster compounds from both the GSK-Chembl Malaria data set and the Zinc database. Spectral clustering algorithms based on the tensor method give robust results on the mid-size compound sets used here. The goal of this paper is to present the clustering of chemical compounds, using a tensor-based multi-view method which proves of value to the medicinal chemistry community. Our findings show compounds of extremely different chemotypes clustering together, this is a hint to the chemogenomics nature of our method.

Adeshola A. Adefioye; Xinhai Liu; Bart De Moor

2013-01-01T23:59:59.000Z

283

Instrumentation requirements from the user's view. [For airbreathing hypersonic engines  

SciTech Connect

The use of combustor diagnostics is considered from the point of view of demonstration of performance of an airbreathing hypersonic engine. The basic need is seen to be that of providing the data necessary to verify performance predictions for the engine as installed in the airplane. This necessitates the use of a diagnostics capability that can provide the inputs required by the computational analyses that will be used to assess this performance. Because of the cost of ground test facilities, a premium is placed on measurement technique reliability and redundancy of instrumentation. A mix of nonintrusive optical techniques and probe-based measurements is seen to be the best approach using current diagnostics capability; one such instrument mix is outlined for a ramjet/scramjet test program. 11 references.

Harsha, P.T.

1988-01-01T23:59:59.000Z

284

High resolution ion Doppler spectroscopy at Prairie View Rotamak  

SciTech Connect

A fast ion Doppler spectroscopy (IDS) diagnostic system is installed on the Prairie View Rotamak to measure ion temperature and plasma flow. The diagnostic employs a single channel photomultiplier tube and a Jarrell-Ash 50 monochromator with a diffraction grating line density of 1180 lines/mm, which allows for first order spectra of 200-600 nm. The motorized gear of the monochromator allows spectral resolution of 0.01 nm. Equal IDS measurements are observed for various impurity emission lines of which carbon lines exhibit stronger intensities. Furthermore, the diagnostics is examined in an experiment where plasma experiences sudden disruption and quick recovery. In this case, the IDS measurements show {approx}130% increase in ion temperature. Flow measurements are shown to be consistent with plasma rotation.

Houshmandyar, Saeid; Yang Xiaokang [Solar Observatory Department, Prairie View A and M University, Prairie View, Texas 77446 (United States); Magee, Richard [Department of Physics, West Virginia University, Morgantown, West Virginia 26506 (United States)

2012-10-15T23:59:59.000Z

285

Mountain View Power Partners II Wind Farm | Open Energy Information  

Open Energy Info (EERE)

Power Partners II Wind Farm Power Partners II Wind Farm Facility Mountain View Power Partners II Sector Wind energy Facility Type Commercial Scale Wind Facility Status In Service Owner MDU Resources Developer SeaWest Energy Purchaser L.A. Department of Water Resources Location San Gorgonio CA Coordinates 33.9095°, -116.734° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":33.9095,"lon":-116.734,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

286

Mysteries of the Deep: What happens inside of MPI on Blue Gene/Q and why it matters  

NLE Websites -- All DOE Office Websites (Extended Search)

Mysteries Mysteries of the Deep: What happens inside of MPI on Blue Gene/Q and why it matters Jeff Hammond Leadership Computing Facility Argonne National Laboratory March 5, 2013 Jeff Hammond PAMI and MPI on BGQ The view from the boat Jeff Hammond PAMI and MPI on BGQ A reason to dive Jeff Hammond PAMI and MPI on BGQ But not too deep Jeff Hammond PAMI and MPI on BGQ Blue Gene/P Communication architecture Jeff Hammond PAMI and MPI on BGQ Blue Gene/Q Communication architecture Jeff Hammond PAMI and MPI on BGQ MPI-3 on Blue Gene/Q There is no official plan to support MPI-3 on Blue Gene/Q but a subset of these features may be available at some point in the future. I have build MPICH-3.0.x on Blue Gene/Q and many things pass while others are completely broken, but this is not a supported usage and you should not do it unless you are l33t h4xz0r. Jeff Hammond PAMI and MPI on BGQ MPI-3 on Blue Gene/Q A portable implementation

287

Homotypic clusters of transcription factor binding sites: a model system for understanding the physical mechanics of gene expression  

E-Print Network (OSTI)

architectures influence the physical mechanisms that ultimately lead to transcription. A first step towards developing a more mechanistic view of CRE organization is to dissect common and simple organizational patterns [1]. One of themost common CRE build- ing... ,25,26].With this new technology, it is possible to experimentally test how different TF binding site organizations influ- ence gene expression. Even with the development of techniques to synthesize DNA more efficiently, it is still very difficult to study how...

Ezer, Daphne; Zabet, Nicolae Radu; Adryan, Boris

2014-08-01T23:59:59.000Z

288

Antibody library project could unlock mysteries of human gene...  

NLE Websites -- All DOE Office Websites (Extended Search)

Mysteries of human gene function Antibody library project could unlock mysteries of human gene function By looking at antibodies, researchers can identify where, in a cell, genes...

289

Regulation of Alpha-Amylase Gene Expression  

Science Journals Connector (OSTI)

The aim of our studies is to elucidate in molecular detail the principles underlying the tissue specific expression of eucaryotic genes. It is hoped that by understanding how a particular gene becomes activated i...

H. C. Hurst; O. Hagenbüchle; U. Schibler…

1986-01-01T23:59:59.000Z

290

The cAMP Response Element Binding protein (CREB) is activated by Insulin-like Growth Factor-1 (IGF-1) and regulates myostatin gene expression in skeletal myoblast  

SciTech Connect

Highlights: •IGF-1 induces the activation of CREB via IGF-1R/PI3K/PLC signaling pathway. •Calcium dependent signaling pathways regulate myostatin gene expression. •IGF-1 regulates myostatin gene expression via CREB transcription in skeletal myoblast. -- Abstract: Myostatin, a member of the Transforming Growth Factor beta (TGF-?) superfamily, plays an important role as a negative regulator of skeletal muscle growth and differentiation. We have previously reported that IGF-1 induces a transient myostatin mRNA expression, through the activation of the Nuclear Factor of Activated T cells (NFAT) in an IP{sub 3}/calcium-dependent manner. Here we examined the activation of CREB transcription factor as downstream targets of IGF-1 during myoblast differentiation and its role as a regulator of myostatin gene expression. In cultured skeletal myoblast, IGF-1 induced the phosphorylation and transcriptional activation of CREB via IGF-1 Receptor/Phosphatidylinositol 3-Kinase (PI3K)/Phospholipase C gamma (PLC ?), signaling pathways. Also, IGF-1 induced calcium-dependent molecules such as Calmodulin Kinase II (CaMK II), Extracellular signal-regulated Kinases (ERK), Protein Kinase C (PKC). Additionally, we examined myostatin mRNA levels and myostatin promoter activity in differentiated myoblasts stimulated with IGF-1. We found a significant increase in mRNA contents of myostatin and its reporter activity after treatment with IGF-1. The expression of myostatin in differentiated myoblast was downregulated by the transfection of siRNA–CREB and by pharmacological inhibitors of the signaling pathways involved in CREB activation. By using pharmacological and genetic approaches together these data demonstrate that IGF-1 regulates the myostatin gene expression via CREB transcription factor during muscle cell differentiation.

Zuloaga, R. [Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago (Chile)] [Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago (Chile); Fuentes, E.N.; Molina, A. [Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago (Chile) [Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago (Chile); Interdisciplinary Center for Aquaculture Research (INCAR), Víctor Lamas 1290, PO Box 160-C, Concepción (Chile); Valdés, J.A., E-mail: jvaldes@unab.cl [Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago (Chile); Interdisciplinary Center for Aquaculture Research (INCAR), Víctor Lamas 1290, PO Box 160-C, Concepción (Chile)

2013-10-18T23:59:59.000Z

291

Gene synthesis by circular assembly amplification  

E-Print Network (OSTI)

Gene synthesis by circular assembly amplification Duhee Bang & George M Church Here we report the development of a gene-synthesis technology, circular assembly amplification. In this approach, we first error-rich products, thereby substantially improving gene-synthesis quality. We used this method

Church, George M.

292

01/04/2008 12:41Gene Expression: The West Group Page 1 of 6http://www.gnxp.com/blog/2008/03/west-group.php  

E-Print Network (OSTI)

01/04/2008 12:41Gene Expression: The West Group Page 1 of 6http://www.gnxp.com/blog/2008/03/west-group.php://www.gnxp.com/blog/2008/03/west-group.php With Movable Type (2003-2005, Movable Type Archives) View RSS Feeds Close:41Gene Expression: The West Group Page 3 of 6http://www.gnxp.com/blog/2008/03/west-group.php EJHG

West, Stuart

293

Genes, Themes and Microarrays Using Information Retrieval for LargeScale Gene Analysis  

E-Print Network (OSTI)

research effort. 4. Due to the interrelated nature of biological processes, genes may have more than

Shatkay, Hagit

294

T-643: HP OpenView Storage Data Protector Unspecified Code Execution  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

643: HP OpenView Storage Data Protector Unspecified Code 643: HP OpenView Storage Data Protector Unspecified Code Execution Vulnerability T-643: HP OpenView Storage Data Protector Unspecified Code Execution Vulnerability June 9, 2011 - 3:45pm Addthis PROBLEM: HP OpenView Storage Data Protector Unspecified Code Execution Vulnerability PLATFORM: Versions 6.0, 6.10, and 6.11 running on HP-UX, Solaris, Linux and Windows. ABSTRACT: A vulnerability has been reported in HP OpenView Storage Data Protector, which can be exploited by malicious people to compromise a vulnerable system. reference LINKS: Secunia Advisory SA44884 CVE-2011-1864 SecurityTracker Alert ID: 1025620 HP Document ID: c02712867 IMPACT ASSESSMENT: High Discussion: A vulnerability was reported in HP OpenView Storage Data Protector. A remote user can execute arbitrary code on the target system.

295

U-025: HP OpenView Network Node Manager Bugs Let Remote Users Execute  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

U-025: HP OpenView Network Node Manager Bugs Let Remote Users U-025: HP OpenView Network Node Manager Bugs Let Remote Users Execute Arbitrary Code U-025: HP OpenView Network Node Manager Bugs Let Remote Users Execute Arbitrary Code November 2, 2011 - 8:00am Addthis PROBLEM: HP OpenView Network Node Manager Bugs Let Remote Users Execute Arbitrary Code. PLATFORM: HP OpenView Network Node Manager (OV NNM) v7.51, v7.53 running on HP-UX, Linux, Solaris, and Windows ABSTRACT: A remote user can execute arbitrary code on the target system. reference LINKS: HP Support Center Document ID: c03054052 SecurityTracker Alert ID: 1026260 CVE-2011-1365 CVE-2011-1366 CVE-2011-1367 IMPACT ASSESSMENT: Medium Discussion: Several vulnerabilities were reported in HP OpenView Network Node Manager. A remote user can execute arbitrary code on the target system.

296

Microsoft Word - A Systems View of the Modern Grid_Final_v2_0.doc  

NLE Websites -- All DOE Office Websites (Extended Search)

V2.0 V2.0 The NETL Modern Grid Initiative A SYSTEMS VIEW OF THE MODERN GRID Conducted by the National Energy Technology Laboratory for the U.S. Department of Energy Office of Electricity Delivery and Energy Reliability January 2007 Office of Electricity Delivery and Energy Reliability Page 1 v2.0 A Systems View of the Modern Grid TABLE OF CONTENTS Table of Contents ..................................................................................... 1 Executive Summary .................................................................................. 2 Creating the Systems View........................................................................ 4 Key Success Factors .................................................................................

297

Magnetotactic Bacteria: A Study of Mam Genes and Metabolism  

E-Print Network (OSTI)

, lacks several hemerythrin genes that might represent a gene island that harbors genes that encode hemerythrin island causes the non-magnetic phenotype or if deletion of magnetosome genes is involved as well

Walker, Lawrence R.

298

Modelling and Extracting the Build-Time Software Architecture View Qiang Tu, Michael W. Godfrey, and Xinyi Dong  

E-Print Network (OSTI)

Modelling and Extracting the Build-Time Software Architecture View Qiang Tu, Michael W. Godfrey-known taxonomies of software ar- chitecture views. We present a simple notation for modelling build-time views, we of a toolkit for extracting and modelling build-time architectural views. 1 Introduction The grand goal

Godfrey, Michael W.

299

Travel, work, and telecommunications: a view of the electronics revolution and its potential impacts  

E-Print Network (OSTI)

Jovanis P. (1983) Telecommunications and alternative workple TRAVEL, WORK, AND TELECOMMUNICATIONS: A VIEW OF THEon opportunities for telecommunications to replace, or

Garrison, William L.; Deakin, Elizabeth

2006-01-01T23:59:59.000Z

300

Development of an ambient lighting monitoring system for radiological image viewing application  

Science Journals Connector (OSTI)

Ambient lighting plays a very important role in radiological image viewing environment. Excessive room ambient lighting (or illuminance) degrades image contrast, introducing veiling glare, diffuse reflectivity...

Ahmad Azlan Che; K. H. Ng; N. F. Mohd. Nasir…

2007-01-01T23:59:59.000Z

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


301

C3Bio.org - Knowledge Base: Miscellaneous: How to View/Download...  

NLE Websites -- All DOE Office Websites (Extended Search)

(.jpg, .jpeg, .jpe, .bmp, .tif, .tiff, .png, .gif) Submit You are here: Home Knowledge Base Miscellaneous How to ViewDownload Video Content? Knowledge Base Main...

302

Concept development for the ITER equatorial port visible/infrared wide angle viewing system  

SciTech Connect

The ITER equatorial port visible/infrared wide angle viewing system concept is developed from the measurement requirements. The proposed solution situates 4 viewing systems in the equatorial ports 3, 9, 12, and 17 with 4 views each (looking at the upper target, the inner divertor, and tangentially left and right). This gives sufficient coverage. The spatial resolution of the divertor system is 2 times higher than the other views. For compensation of vacuum-vessel movements, an optical hinge concept is proposed. Compactness and low neutron streaming is achieved by orienting port plug doglegs horizontally. Calibration methods, risks, and R and D topics are outlined.

Reichle, R.; Beaumont, B.; Boilson, D.; Bouhamou, R.; Direz, M.-F.; Encheva, A.; Henderson, M.; Kazarian, F.; Lamalle, Ph.; Lisgo, S.; Mitteau, R.; Patel, K. M.; Pitcher, C. S.; Pitts, R. A.; Prakash, A.; Raffray, R.; Schunke, B.; Snipes, J.; Diaz, A. Suarez; Udintsev, V. S. [ITER Organization, Route de Vinon-sur-Verdon, 13115 St Paul-lez-Durance (France); and others

2012-10-15T23:59:59.000Z

303

Method for determining gene knockouts  

DOE Patents (OSTI)

A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.

Maranas, Costa D; Burgard, Anthony R; Pharkya, Priti

2013-06-04T23:59:59.000Z

304

Gene Therapy for Color Blindness  

Science Journals Connector (OSTI)

...injection of a recombinant, replication-defective adeno-associated virus (AAV) (Figure 1). Before injection, blue-green and red-violet colors were invisible to the monkeys, as determined by a computer-based test of color vision. Five months after injection, the monkeys were found to have trichromatic vision... The subretinal introduction of a gene encoding an opsin into two color-blind monkeys lacking that opsin resulted in the acquisition of trichromatic vision.

Bennett J.

2009-12-17T23:59:59.000Z

305

Enhancement of photoassimilate utilization by manipulation of the ADPglucose pyrophosphorylase gene. Progress report, [April 15, 1987--April 14, 1988  

SciTech Connect

Many agronomically important crops are viewed as significant resources of renewable energy. Overall crop productivity could be increased if the efficiency of photoassimilate conversion into dry matter such as starch were improved in storage tissues. Starch production is controlled by the catalytic activity of ADPglucose pyrophosphorylase in the first step of starch biosynthesis. This research focuses on the genetic structure and molecular mechanisms by which it is controlled during plant development and how it is affected by environmental and hormonal conditions. The current goal is to isolate the genes for this enzyme present in both cereal endosperm and potato tuber tissues, and to elucidate its structure and the controlling sequences responsible for gene expression. The long term goal is the improvement of starch production in storage organs by manipulating this gene so that it encodes an enzyme refractive to inorganic phosphate inhibition.

Okita, T.W.

1988-12-31T23:59:59.000Z

306

Recombinant HT{sub m4} gene, protein and assays  

DOE Patents (OSTI)

The invention relates to a recombinant DNA molecule which encodes a HT{sub m4} protein, a transformed host cell which has been stably transfected with a DNA molecule which encodes a HT{sub m4} protein and a recombinant HT{sub m4} protein. The invention also relates to a method for detecting the presence of a hereditary atopy. 2 figs.

Lim, B.; Adra, C.N.; Lelias, J.M.

1996-09-03T23:59:59.000Z

307

Defining Multi-Disciplinary Views of a Computer Model of Buildings  

E-Print Network (OSTI)

Defining Multi-Disciplinary Views of a Computer Model of Buildings Robert W. Amor and Dr John G is the development, and maintenance, of multiple views of the building model as required by different disciplines method of accessing information in product data models to facilitate use by different building

Amor, Robert

308

The Universe Viewed in Gamma-Rays 1 Properties of Gamma-ray Bursts Localized by  

E-Print Network (OSTI)

The Universe Viewed in Gamma-Rays 1 Properties of Gamma-ray Bursts Localized by the HETE-2 and localize Gamma-ray bursts (GRBs) in wide field of view. HETE-2 have been localized about 20 GRBs per year hours after the burst. 1. The High Energy Transient Explorer 2 Gamma-ray burst (GRB) is the most

Enomoto, Ryoji

309

Service-Oriented Architecture for VIEW: a Visual Scientific Workflow Management System  

E-Print Network (OSTI)

Service-Oriented Architecture for VIEW: a Visual Scientific Workflow Management System Cui Lin architecture, we further propose a service-oriented archi- tecture for VIEW (a VIsual sciEntific Workflow discoveries. In contrast to business workflows, which are typically controlflow oriented, scien- tific

Hua, Jing

310

View a Grant This user guide will explain how to a Grant record in IRMA  

E-Print Network (OSTI)

View a Grant This user guide will explain how to a Grant record in IRMA LOGGING ON TO IRMA: 1. Open. Click "Login" to log into IRMA VIEW A GRANT RECORD: 1) After logging on, you should see something like;Printed: 16 November 2012 2/3 3) Click on the "List Existing Records" under the Contracts/ Grants icon

311

Co-sponsored by CEMS and ME Departments The Outlook for Energy: A View  

E-Print Network (OSTI)

ABSTRACT The Outlook for Energy is ExxonMobil's long-term view of our shared energy future. We developCo-sponsored by CEMS and ME Departments The Outlook for Energy: A View to 2040 Charles (Chuck) Darnell Manager, Research and Development Support Services ExxonMobil Research & Engineering Company

Fisher, Frank

312

Co-sponsored by ME and CEMS Departments The Outlook for Energy: A View  

E-Print Network (OSTI)

ABSTRACT The Outlook for Energy is ExxonMobil's long-term view of our shared energy future. We developedCo-sponsored by ME and CEMS Departments The Outlook for Energy: A View to 2040 By Charles (Chuck) Darnell Manager, Research and Development Support Services ExxonMobil Research & Engineering Company

Fisher, Frank

313

Hierarchical multi-view representation of spatial data; application to the analysis of Corsican Neolithic tombs.  

E-Print Network (OSTI)

Hierarchical multi-view representation of spatial data; application to the analysis of Corsican and views of spatial data for analyzing archeological data. This interdisciplinary project begins in the Corsica Island. · GIS representation of the previous data through spatial entities · Analysis

Paris-Sud XI, Université de

314

Fast and adaptive network of spiking neurons for multi-view visual pattern recognition  

E-Print Network (OSTI)

spent on processing information. In relation to the optimization procedure according to the energy efficiency criteria, mammalian brains have $1010 neurons [16], with neurons operating with a very low sponta different views of an object through synaptic plasticity and structural adaptation; multiple view

Benuskova, Luba

315

Fast 3D keypoints detector and descriptor for view-based 3D objects recognition  

E-Print Network (OSTI)

Fast 3D keypoints detector and descriptor for view-based 3D objects recognition Ayet Shaiek1 Abstract. In this paper, we propose a new 3D object recognition method that employs a set of 3D keypoints extracted from point cloud representation of 3D views. The method makes use of the 2D organization of range

Paris-Sud XI, Université de

316

Prairie View A&M University | Princeton Plasma Physics Lab  

NLE Websites -- All DOE Office Websites (Extended Search)

Prairie View A&M University Prairie View A&M University Prairie View A&M University, Historically Black College and University (HBCU) Professor Tian-sen Huang The Prairie View Plasma Lab (PVPL) is the only fusion plasma lab operated at an HBCU, and a major research and education laboratory at Prairie View A&M University (PVAMU). The lab has two rotamak devices supported by two 500kHz/400 kW rf generators to operate a rotating magnetic field drive-FRC plasma. Since PVPL 2001, PPPL/OSUR provided significant technical and material support during the lab's construction, and assisted in the installation and initial operation of the rotomak FRC plasma device. Because there is no engineering support service at PVAMU, PPPL organized an engineering team that gave the PVPL team assistance in assembling the

317

T-704: RSA enVision Lets Remote Users View Files and Remote Authenticated  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

704: RSA enVision Lets Remote Users View Files and Remote 704: RSA enVision Lets Remote Users View Files and Remote Authenticated Users Obtain Password T-704: RSA enVision Lets Remote Users View Files and Remote Authenticated Users Obtain Password August 29, 2011 - 3:45am Addthis PROBLEM: Allows remote attackers to obtain sensitive information by sniffing the network or leveraging access to a recipient mailbox. PLATFORM: RSA enVision Version(s): 3.x, 4.x ABSTRACT: RSA enVision lets remote users view files and remote authenticated users obtain password. reference LINKS: SecurityTracker Alert ID: 1025979 CVE-2011-2736 CVE-2011-2737 RSA enVision Product Security IMPACT ASSESSMENT: Medium Discussion: Two vulnerabilities were reported in RSA enVision. A remote user can view files on the target system. A remote authenticated user can obtain

318

T-704: RSA enVision Lets Remote Users View Files and Remote Authenticated  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

4: RSA enVision Lets Remote Users View Files and Remote 4: RSA enVision Lets Remote Users View Files and Remote Authenticated Users Obtain Password T-704: RSA enVision Lets Remote Users View Files and Remote Authenticated Users Obtain Password August 29, 2011 - 3:45am Addthis PROBLEM: Allows remote attackers to obtain sensitive information by sniffing the network or leveraging access to a recipient mailbox. PLATFORM: RSA enVision Version(s): 3.x, 4.x ABSTRACT: RSA enVision lets remote users view files and remote authenticated users obtain password. reference LINKS: SecurityTracker Alert ID: 1025979 CVE-2011-2736 CVE-2011-2737 RSA enVision Product Security IMPACT ASSESSMENT: Medium Discussion: Two vulnerabilities were reported in RSA enVision. A remote user can view files on the target system. A remote authenticated user can obtain

319

Gene Therapy and Biological Pacing  

Science Journals Connector (OSTI)

...stem-cell vehicles to deliver ion-channel genes to the heart, and with the injection of biological pacemakers derived from embryonic stem cells (Figure 1), the report by Hu et al. is only the second in large animals to describe a biological pacemaker that induces heart rates and autonomic function that... TBX18 is a transcription factor critical to the specification of the sinoatrial node during normal development. A recent pig model of heart block suggests that the injection of a vector carrying TBX18 induces physiologically relevant pacemaker activity for 11 days.

Rosen M.R.

2014-09-18T23:59:59.000Z

320

Cross-Ontological Analytics: Combining Associative and Hierarchical Relations in the Gene Ontologies to Assess Gene Product Similarity  

SciTech Connect

Gene and gene product similarity is a fundamental diagnostic measure in analyzing biological data and constructing predictive models for functional genomics. With the rising influence of the gene ontologies, two complementary approaches have emerged where the similarity between two genes/gene products is obtained by comparing gene ontology (GO) annotations associated with the gene/gene products. One approach captures GO-based similarity in terms of hierarchical relations within each gene ontology. The other approach identifies GO-based similarity in terms of associative relations across the three gene ontologies. We propose a novel methodology where the two approaches can be merged with ensuing benefits in coverage and accuracy.

Posse, Christian; Sanfilippo, Antonio P.; Gopalan, Banu; Riensche, Roderick M.; Beagley, Nathaniel; Baddeley, Bob L.

2006-05-28T23:59:59.000Z

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


321

A fruit quality gene map of Prunus  

E-Print Network (OSTI)

Central Open Access A fruit quality gene map of PrunusAbstract Background: Prunus fruit development, growth,and maintaining stone fruit quality from production and

Ogundiwin, Ebenezer A; Peace, Cameron P; Gradziel, Thomas M; Parfitt, Dan E; Bliss, Fredrick A; Crisosto, Carlos H

2009-01-01T23:59:59.000Z

322

Imaging Gene Expression | The Ames Laboratory  

NLE Websites -- All DOE Office Websites (Extended Search)

Imaging Gene Expression FWPProject Description: Project Leader(s): Marit Nilsen-Hamilton Principal Investigators: George Kraus We are developing apatmers to use as cellular...

323

LSUHSC NEW ORLEANS GENE THERAPY PUBLICATIONS  

E-Print Network (OSTI)

delivery of galactocerebrosidase tagged with the HIV Tat protein transduction domain. Journal-Negative Rev Gene Into Human CD34(+) Hematopoietic Progenitor Cells Potently Inhibits HIV-1 Replication

324

GeneFarm, structural and functional annotation of Arabidopsis gene and protein families by a network  

E-Print Network (OSTI)

, and more secure planning and design of experiments. The purpose of the GeneFarmprojectis to obtain

Gent, Universiteit

325

Gene-set Cohesion Analysis Tool (GCAT): A literature based web tool for calculating functional cohesiveness of gene groups  

Science Journals Connector (OSTI)

Numerous algorithms exist for producing gene sets from high-throughput genomic and proteomic technologies. However, analysis of the functional significance of these groups of genes or proteins remains a big challenge. We developed a Web based system ... Keywords: interferon, gene set cohesion analysis tool, functional cohesiveness, gene groups, genomics, proteomics, latent semantic indexing, gene ontology, embryonic fibroblasts, literature based Web tool, gene-gene literature similarities, microarray data analysis

Lijing Xu; R. Homayouni; N. A. Furlotte; K. E. Heinrich; E. O. George; M. W. Berry

2009-11-01T23:59:59.000Z

326

Designing and characterizing artificial transcription factors targeting critical embryonic stem cell self- renewal and pluripotency genes in somatic cells  

E-Print Network (OSTI)

regardless of cells type and GFP-DRP fusion construct (the DRP-GFP fusion protein in the mouse cell types that werefusion protein in all successfully transfected cell types.

Yang, Steven

2009-01-01T23:59:59.000Z

327

Pathogenic Influenza Viruses and Coronaviruses Utilize Similar and Contrasting Approaches To Control Interferon-Stimulated Gene Responses  

Science Journals Connector (OSTI)

...SARS-CoV, maintains a purported nuclear localization signal, exhibits nuclear localization based on transfection...complex RNA and proteomics datasets across different virus infections...comparisons across systems virology datasets alleviated these problems and...

Vineet D. Menachery; Amie J. Eisfeld; Alexandra Schäfer; Laurence Josset; Amy C. Sims; Sean Proll; Shufang Fan; Chengjun Li; Gabriele Neumann; Susan C. Tilton; Jean Chang; Lisa E. Gralinski; Casey Long; Richard Green; Christopher M. Williams; Jeffrey Weiss; Melissa M. Matzke; Bobbie-Jo Webb-Robertson; Athena A. Schepmoes; Anil K. Shukla; Thomas O. Metz; Richard D. Smith; Katrina M. Waters; Michael G. Katze; Yoshihiro Kawaoka; Ralph S. Baric

2014-06-01T23:59:59.000Z

328

Gene therapy in alcoholic rats  

NLE Websites -- All DOE Office Websites (Extended Search)

70 70 Sept. 9, 2001 Gene Therapy Reduces Drinking in "Alcoholic" Rats UPTON, NY - Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have shown that increasing the level of a brain protein important for transmitting pleasure signals can turn rats that prefer alcohol into light drinkers, and those with no preference into near teetotalers. The findings, published in the first September 2001 issue of the Journal of Neurochemistry (Vol. 78, No. 5), may have implications for the prevention and treatment of alcoholism in humans. "This is a preliminary study, but when you see a rat that chooses to drink 80 to 90 percent of its daily fluid as alcohol, and then three days later it's down to 20 percent, that's a dramatic drop in alcohol intake - a very clear change in behavior," said Panayotis Thanos, the lead researcher. "This gives us great hope that we can refine this treatment for future clinical use."

329

Assignment of Orthologous Genes via Genome Rearrangement  

E-Print Network (OSTI)

Assignment of Orthologous Genes via Genome Rearrangement Xin Chen, Jie Zheng, Zheng Fu, Peng Nan of genomes is a fundamental and challenging problem in comparative genomics. Existing methods that assign sequence similarity and evolutionary events at a genome level, where orthologous genes are assumed

Lonardi, Stefano

330

Gene prediction by multiple spliced alignment  

Science Journals Connector (OSTI)

With recent advances in sequencing technologies, a huge amount of DNA sequences become available year after year. In order to obtain useful information on these sequences, we need to process them in search of biologically meaningful regions. The genes ... Keywords: comparative genomics, gene prediction, multiple spliced alignment

Rodrigo Mitsuo Kishi; Ronaldo Fiorilo dos Santos; Said Sadique Adi

2011-08-01T23:59:59.000Z

331

Targets and indicators for gene level biodiversity  

E-Print Network (OSTI)

Targets and indicators for gene level biodiversity Resilience and future adaptation in forests, inland waters and marine environments depend on genetic variation Welcome to the Side-event on Lunch.weibull@naturvardsverket.se BaltGene­BalticSeaGeneticBiodiversity www.tmbl.gu.se:16080/baltgene GeneticMonitoring http

332

Gene coding for the E1 endoglucanase  

DOE Patents (OSTI)

The gene encoding Acidothermus cellulolyticus E1 endoglucanase is cloned and expressed in heterologous microorganisms. A new modified E1 endoglucanase enzyme is produced along with variants of the gene and enzyme. The E1 endoglucanase is useful for hydrolyzing cellulose to sugars for simultaneous or later fermentation into alcohol. 6 figs.

Thomas, S.R.; Laymon, R.A.; Himmel, M.E.

1996-07-16T23:59:59.000Z

333

Multi-view modeling and pragmatics in 2020: position paper on designing complex cyber-physical systems  

Science Journals Connector (OSTI)

Multi-view modeling refers to a system designer constructing distinct and separate models of the same system to model different (semantic) aspects of a system. Modeling pragmatics also entails constructing different views of a system, but ...

Reinhard von Hanxleden; Edward A. Lee; Christian Motika; Hauke Fuhrmann

2012-03-01T23:59:59.000Z

334

Creating a methodology and tool to capture and resolve conflicts in developing software requirements: Requirement Lifecycle Modeling Views manager (RLMV)  

E-Print Network (OSTI)

for change. Fig. 2. The Revision View in RLMV The purpose of the Use Case View is to describe "the behavior of the system as seen by its end users, analysts, and testers" (Booch, Jacobson, and Rumbaugh, 1999). It does not specify the organization.... . Code Implementation. . User Interface. 4 9 13 13 FUTURE IMPROVEMENTS. 16 CONCLUSION. 17 REFERENCES. APPENDIX A. 19 LIST OF FIGURES FIGURE I Requirement View implemented in RLMV. . . . . PAGE 2 Revision View implemented in RLMV...

Herrera, Leeha Rae-Lyn

2013-02-22T23:59:59.000Z

335

U-008: Symantec Data Loss Prevention Bugs in KeyView Filter Lets Remote  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

08: Symantec Data Loss Prevention Bugs in KeyView Filter Lets 08: Symantec Data Loss Prevention Bugs in KeyView Filter Lets Remote Users Deny Service U-008: Symantec Data Loss Prevention Bugs in KeyView Filter Lets Remote Users Deny Service October 11, 2011 - 8:00am Addthis PROBLEM: Symantec Data Loss Prevention Bugs in KeyView Filter Lets Remote Users Deny Service PLATFORM: Symantec Data Loss Prevention Enforce/Detection Servers for Windows 10.x, 11.x ABSTRACT: A remote user can create a file that, when processed by the target filter, will cause partial denial of service conditions. reference LINKS: Symantec Security Advisory SYM11-013 SecurityTracker Alert ID: 1026157 IMPACT ASSESSMENT: Medium Discussion: Multiple vulnerabilities were reported in Symantec Data Loss Prevention. A remote user can cause denial of service conditions on the target system.A

336

ParaView Red Blood Cell Tutorial on Eureka/Gadzooks | Argonne Leadership  

NLE Websites -- All DOE Office Websites (Extended Search)

Red Blood Cell Tutorial on Eureka/Gadzooks Red Blood Cell Tutorial on Eureka/Gadzooks Goals This tutorial is intended to be a hands-on resource for users interested in learning the basic concepts of ParaView. The examples can easily be run on a laptop, using the example data set provided. Tour of ParaView Show range of visualization methods Walk through various visualization techniques, hopefully illustrate how these can apply to your own data. Feel for ParaView "way" Terminology and step-by-step process peculiar to ParaView, which may differ from other packages, e.g. VisIt. cutting planes: close-up RBCs: close-up RBC: Continuum Data The data used for this tutorial is: Blood flow simulation data Multiple data types Continuum data field (unstructured mesh, tetrahedral): fluid field, plasma

337

DOE Solicits Views on the Implementation of Large-Capacity Clothes Washer  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Solicits Views on the Implementation of Large-Capacity Clothes Solicits Views on the Implementation of Large-Capacity Clothes Washer Waivers DOE Solicits Views on the Implementation of Large-Capacity Clothes Washer Waivers November 30, 2010 - 10:56am Addthis The Department of Energy has recently granted several requests for waivers establishing an alternative test procedure for certain large-capacity residential clothes washer models. We have now received follow-up questions about the proper application of these waivers. Since these questions affect multiple manufacturers and the public, we have decided the proper course is to invite interested parties to submit views on the proper application of these waivers to existing clothes washer models and units by Tuesday, December 7th. The Department's current test procedure for residential clothes washers

338

Imperial Sea View Hot Springs Pool & Spa Low Temperature Geothermal  

Open Energy Info (EERE)

Sea View Hot Springs Pool & Spa Low Temperature Geothermal Sea View Hot Springs Pool & Spa Low Temperature Geothermal Facility Jump to: navigation, search Name Imperial Sea View Hot Springs Pool & Spa Low Temperature Geothermal Facility Facility Imperial Sea View Hot Springs Sector Geothermal energy Type Pool and Spa Location Niland, California Coordinates 33.2400366°, -115.5188756° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[]}

339

NREL: Awards and Honors - PowerView Semi-Transparent Photovoltaic Module  

NLE Websites -- All DOE Office Websites (Extended Search)

PowerView(tm) Semi-Transparent Photovoltaic Module PowerView(tm) Semi-Transparent Photovoltaic Module Developers: Harrin Ullal, Ken Zweibel, and Bolko von Roedern, National Renewable Energy Laboratory; Robert S. Oswald and Frank Liu, BP Solar The PowerView(tm) module - a BP Solar commercial product - represents the coming of a new era in photovoltaics for buildings. Because it is semi-transparent, it can be used in lieu of architectural glass for many applications, particularly for those that call for sloped glazing, such as awnings, canopies, or slanted roofs. And because it is photovoltaics, the module uses sunlight to generate clean electricity to power a building's electrical needs. As testimony to the PowerView's utility BP Solar has already installed it on canopies of hundreds of its Connect stores -

340

View the Apps for Vehicles Phase One Submissions | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

View the Apps for Vehicles Phase One Submissions View the Apps for Vehicles Phase One Submissions View the Apps for Vehicles Phase One Submissions January 24, 2013 - 11:13am Addthis 9 of the 37 entries for the Apps for Vehicles competition. 9 of the 37 entries for the Apps for Vehicles competition. Ian Kalin Director of the Energy Data Initiative How can I participate? Visit the competition website to view the submitted ideas. Starting on March 15, you'll be able to vote for your favorite completed apps. Apps for Vehicles The Open Data Initiative reached another milestone last week with the completion of the first phase of the Apps for Vehicles Challenge. This incentive-based competition seeks to improve safety and fuel efficiency through data innovation. Thirty-seven entries were submitted to the Challenge's judges, which are all publically viewable on the competition

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


341

Cleaning Robot Navigation Using Panoramic Views and Particle Clouds as Landmarks Ralf Moller  

E-Print Network (OSTI)

Technology", Bielefeld University, D-33594 Bielefeld, Germany Abstract The paper describes a visual methodCleaning Robot Navigation Using Panoramic Views and Particle Clouds as Landmarks Ralf M Engineering, Faculty of Technology, Bielefeld University, Center of Excellence "Cognitive Interaction

Moeller, Ralf

342

444 NATURE PHYSICS | VOL 8 | JUNE 2012 | www.nature.com/naturephysics news & views  

E-Print Network (OSTI)

444 NATURE PHYSICS | VOL 8 | JUNE 2012 | www.nature.com/naturephysics news & views on which camp that can be easily manipulated and observed: from eighteenth-century orreries to the twentieth-century

Loss, Daniel

343

SCIENCE ON SATURDAY- "A Robot's View of Our Ocean Planet" | Princeton...  

NLE Websites -- All DOE Office Websites (Extended Search)

16, 2013, 9:30am Science On Saturday MBG Auditorium SCIENCE ON SATURDAY- "A Robot's View of Our Ocean Planet" Professor Josh Kohut, Assistant Professor of Oceanography Center for...

344

Layered View of QoS Issues in IP-Based Mobile Wireless Networks Honeywell Labs  

E-Print Network (OSTI)

Layered View of QoS Issues in IP-Based Mobile Wireless Networks Haowei Bai Honeywell Labs 3660 Technology Drive, Minneapolis, MN 55418 E-mail: haowei.bai@honeywell.com Mohammed Atiquzzaman School

Minnesota, University of

345

E-Print Network 3.0 - adams view system Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

ou Recherche avec licence Site INSA ou serveur de jetons ORACLE LabView... ABAQUS MATLAB MAPLE SOLID EDGE FEMAP NX-CAM ... Source: Stouls, Nicolas - Centre of Innovation in...

346

NATURE NANOTECHNOLOGY | VOL 7 | FEBRUARY 2012 | www.nature.com/naturenanotechnology 81 news & views  

E-Print Network (OSTI)

NATURE NANOTECHNOLOGY | VOL 7 | FEBRUARY 2012 | www.nature.com/naturenanotechnology 81 news & views's medical care (personalized medicine) -- nanopore sequencing techniques compete with fluorescent in Nature Nanotechnology, Charles Lieber and colleagues at Harvard University, Nanyang Technological

Bielefeld, Universität

347

84 nature nanotechnology | VOL 4 | FEBRUARY 2009 | www.nature.com/naturenanotechnology news & views  

E-Print Network (OSTI)

84 nature nanotechnology | VOL 4 | FEBRUARY 2009 | www.nature.com/naturenanotechnology news & views with living matter will open up fundamentally new opportunities in medicine and diagnostics. This knowledge

Granick, Steve

348

Cellulosic Biofuels: Expert Views on Prospects for Advancement and Jeffrey Keisler  

E-Print Network (OSTI)

Cellulosic Biofuels: Expert Views on Prospects for Advancement Erin Baker and Jeffrey Keisler funding and the likelihood of achieving advances in cellulosic biofuel technologies. While in collecting more information on this technology. Keywords: Biofuels; Technology R&D; Uncertainty

Massachusetts at Amherst, University of

349

176 nature nanotechnology | VOL 5 | MARCH 2010 | www.nature.com/naturenanotechnology news & views  

E-Print Network (OSTI)

176 nature nanotechnology | VOL 5 | MARCH 2010 | www.nature.com/naturenanotechnology news & views P humidity. Writing in Nature Nanotechnology, Saeed Moghaddam, Mark Shannon and colleagues1 at the University

Buratto, Steve

350

A manual procedure for assembly sequence planning based on the exploded view method  

E-Print Network (OSTI)

This thesis covers the development of a manual planning procedure based on the computerized method of exploded views to generate an optimal or near-optimal assembly sequence. Care has been taken to minimize iterative and tedious operations and make...

Rivero, Andres R

2012-06-07T23:59:59.000Z

351

Early View (EV): 1-EV High connectivity among habitats precludes the relationship  

E-Print Network (OSTI)

Early View (EV): 1-EV High connectivity among habitats precludes the relationship between dispersal such as currents and larval behaviors (reviewed in Mora and Sale 2002), the use of PLD as a quantitative measure

Roy, Denis

352

GPU-based Scalable Volumetric Reconstruction for Multi-view Stereo  

SciTech Connect

We present a new scalable volumetric reconstruction algorithm for multi-view stereo using a graphics processing unit (GPU). It is an effectively parallelized GPU algorithm that simultaneously uses a large number of GPU threads, each of which performs voxel carving, in order to integrate depth maps with images from multiple views. Each depth map, triangulated from pair-wise semi-dense correspondences, represents a view-dependent surface of the scene. This algorithm also provides scalability for large-scale scene reconstruction in a high resolution voxel grid by utilizing streaming and parallel computation. The output is a photo-realistic 3D scene model in a volumetric or point-based representation. We demonstrate the effectiveness and the speed of our algorithm with a synthetic scene and real urban/outdoor scenes. Our method can also be integrated with existing multi-view stereo algorithms such as PMVS2 to fill holes or gaps in textureless regions.

Kim, H; Duchaineau, M; Max, N

2011-09-21T23:59:59.000Z

353

Interactive Training: Getting Started with ParaView for DOE Users...  

NLE Websites -- All DOE Office Websites (Extended Search)

https:www.alcf.anl.govworkshopsparaviewwebinar Getting Started with ParaView for DOE Users REGISTER On November 5, join us for a two-hour, interactive videoconference that...

354

Ecology in Africa: a view from the past for informing the future  

E-Print Network (OSTI)

reviews ISSN 1948?6596  Ecology in Africa: a view from the the future  African Ecology – Benchmarks and Historical s  role  in  shaping  the  ecology  of  Africa…”.   These 

Martins, Dino J.

2013-01-01T23:59:59.000Z

355

V-195: RSA Authentication Manager Lets Local Users View the Administra...  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

can view the administrative account password SOLUTION: The vendor has issued a fix (Patch 26 (P26) for RSA Authentication Manager 7.1 Service Pack 4 (SP4) and Appliance 3.0...

356

Satellite Photograph Presents First Comprehensive View of Local Wind: The Santa Ana  

Science Journals Connector (OSTI)

...January 1973 Santa Ana wind condition reveals local atmospheric dynamics...imagery. The Santa Ana wind implies very specific...conservationists. A Santa Ana (a foehn type wind) may develop...Comprehensive View of Local Wind: The Santa Ana Abstract...

Leonard W. Bowden; Jates R. Huning; Charles F. Hutchinson; Claude W. Johnson

1974-06-07T23:59:59.000Z

357

V-195: RSA Authentication Manager Lets Local Users View the Administrative  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

95: RSA Authentication Manager Lets Local Users View the 95: RSA Authentication Manager Lets Local Users View the Administrative Account Password V-195: RSA Authentication Manager Lets Local Users View the Administrative Account Password July 9, 2013 - 12:51am Addthis PROBLEM: RSA Authentication Manager Lets Local Users View the Administrative Account Password PLATFORM: RSA Authentication Manager 7.1, 8.0 ABSTRACT: A vulnerability was reported in RSA Authentication Manager. REFERENCE LINKS: SecurityTracker Alert ID: 1028742 CVE-2013-3273 RSA IMPACT ASSESSMENT: Medium DISCUSSION: When the RSA Authentication Manager Software Development Kit (SDK) is used to develop a custom application that connects with RSA Authentication Manager and the trace logging is set to verbose, the administrative account password used by the custom application is written in clear text to trace

358

Association and Interactions between DNA Repair Gene Polymorphisms and Adult Glioma  

Science Journals Connector (OSTI)

...analyzing gene-gene and gene-environment interactions. First, using...professions were also pilots and engineers. Of the 373 cases, 214...Gene-Gene and Gene-Environment Interactions Analysis Cumulative...for gene-gene and gene-environment interactions on glioma risk...

Yanhong Liu; Michael E. Scheurer; Randa El-Zein; Yumei Cao; Kim-Anh Do; Mark Gilbert; Kenneth D. Aldape; Qingyi Wei; Carol Etzel; and Melissa L. Bondy

2009-01-01T23:59:59.000Z

359

Learning to Associate Faces across Views in Vector Space of Similarities to Prototypes  

E-Print Network (OSTI)

the view-sphere. We describe an automatic face data acquisition system based on a magnetic sensor and a calibrated camera. The system enabled us to obtain systematically a database of face images with labelled 3D poses across a view-sphere of £¥¤§¦§¨ yaw and £¥©¦ ¨ tilt at intervals of ¦ ¨ . The database was used

Gong, Shaogang

360

Thomas Jefferson's administration as viewed by his contemporaries in New England  

E-Print Network (OSTI)

THOMAS JEPZERSON'S ADMINISTRATION AS VIEWED BY HIS CONTEMPORARIES IN NZW ENGLAND A . Thesis by MARILYN ELAINE JARCHOW Submitted to the Graduate College of Texas AkM University in partial fulfillment of the requirement for the degree...(M ea o epar men em er August 1970 ABSTRACT Thomas Jefferson's Administration as Viewed by His Contemporaries in New England. (August 1970) Marilyn Elaine Jarohow, B. A. , California State College at Fullerton; Direoted by& Dr. Joseph M. Nance...

Jarchow, Marilyn Elaine

2012-06-07T23:59:59.000Z

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


361

Estimating the aggregate amenity value of woodland views using spatial analysis  

E-Print Network (OSTI)

(ha) 79,132 51,488 Broadleaved area inside urban and within 300m of urban (ha) 6,657 7,670 Urban area urban buffer · Population with a view · Proportional to area with a view · Monetary valuation using settlements polygons · population of 1,000 and above (mid-2005 from ONS and Census) · area size of at least 20

362

Prairie View A&M University Whole Campus Energy Report Update  

E-Print Network (OSTI)

. This updated report presents an analysis of whole-campus energy consumption at the Prairie View A&M Campus where whole-campus indices were developed that normalize for weather, conditioned area, and campus enrollment. The resultant indices were then used.... Introduction This report presents results of an analysis of energy consumption at the Texas A&M Prairie View Campus. This analysis develops indices that are normalized for weather, conditioned area, and campus enrollment. The resultant indices are then used...

Haberl, J. S.; Claridge, D. E.; Turner, W. D.

1992-01-01T23:59:59.000Z

363

Rhetorical point of view: The manipulation of audience and "speaking voice" to improve student writing.  

E-Print Network (OSTI)

RHETORICAL POINT OF VIEW: THE MANIPULATION OF AUDIENCE AND "SPEAKING VOICE" 10 IMPROVE STUDENT WRITING A Thesis by Nancy Garrett Atkinson Submitted to the Graduate College of Texas A&M University l. n partial fulfillment of the requirement... for the degree of MASTER OF AR1S August 1970 Major Subject: English RHETORICAL POINT OF VIEW: THE MANIPULATION OF AUDIENCE AND "SPEAKING VOICE" TO IMPROVE STUDENT WRITING A Thesis by Nancy Garrett Atkinson Approved as to style and content by: (Chairma...

Atkinson, Nancy Garrett

1970-01-01T23:59:59.000Z

364

A solution to the next best view problem based on D-Spheres for 3D object recognition  

Science Journals Connector (OSTI)

This paper describes a new strategy of optimal view point selection for 3D object recognition purposes. Feature vectors of an object viewed from specific viewpoints are mapped on the nodes of a tessellated sphere which we call D-Sphere. The next best ... Keywords: 3D recognition, active recognition system, next best view

Elizabeth González; Antonio Adán; Vicente Feliú; Luis Sánchez

2008-02-01T23:59:59.000Z

365

Tissue-Specific Gene Delivery via Nanoparticle Coating  

E-Print Network (OSTI)

The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant ...

Harris, Todd J.

366

Comparative gene identification in mammalian, fly, and fungal genomes  

E-Print Network (OSTI)

An important step in genome interpretation is the accurate identification of protein-coding genes. One approach to gene identification is comparative analysis of the genomes of several related species, to find genes that ...

Lin, Michael F. (Michael Fong-Jay)

2006-01-01T23:59:59.000Z

367

Development of nuclear receptor transfected Caco-2 cell lines  

E-Print Network (OSTI)

Reinisalo ? Technical assistance: Paula Nyyss?nen, Markku Taskinen ? Collaboration: Professor Pelkonen's group (Univ. Oulu, Finland) ? Funding: Finnish Funding Agency for Technology and Innovation (TEKES) ...

Korjamo, Timo

2006-10-27T23:59:59.000Z

368

Computationally Optimised DNA Assembly of synthetic genes  

Science Journals Connector (OSTI)

Gene synthesis is hampered by two obstacles: improper assembly of oligonucleotides; oligonucleotide defects incurred during chemical synthesis. To overcome the first problem, we describe the employment of a Computationally Optimised DNA Assembly (CODA) algorithm that uses the degeneracy of the genetic code to design overlapping oligonucleotides with thermodynamic properties for self-assembly into a single, linear, DNA product. To address the second problem, we describe a hierarchical assembly strategy that reduces the incorporation of defective oligonucleotides into full-length gene constructs. The CODA algorithm and these biological methods enable fast, simple and reliable assemblies of sequence-correct full-length genes.

Liza S.Z. Larsen; Christopher D. Wassman; G. Wesley Hatfield; Richard H. Lathrop

2008-01-01T23:59:59.000Z

369

Heat induces gene amplification in cancer cells  

SciTech Connect

Highlights: Black-Right-Pointing-Pointer This study discovered that heat exposure (hyperthermia) results in gene amplification in cancer cells. Black-Right-Pointing-Pointer Hyperthermia induces DNA double strand breaks. Black-Right-Pointing-Pointer DNA double strand breaks are considered to be required for the initiation of gene amplification. Black-Right-Pointing-Pointer The underlying mechanism of heat-induced gene amplification is generation of DNA double strand breaks. -- Abstract: Background: Hyperthermia plays an important role in cancer therapy. However, as with radiation, it can cause DNA damage and therefore genetic instability. We studied whether hyperthermia can induce gene amplification in cancer cells and explored potential underlying molecular mechanisms. Materials and methods: (1) Hyperthermia: HCT116 colon cancer cells received water-submerged heating treatment at 42 or 44 Degree-Sign C for 30 min; (2) gene amplification assay using N-(phosphoacetyl)-L-aspartate (PALA) selection of cabamyl-P-synthetase, aspartate transcarbarmylase, dihydro-orotase (cad) gene amplified cells; (3) southern blotting for confirmation of increased cad gene copies in PALA-resistant cells; (4) {gamma}H2AX immunostaining to detect {gamma}H2AX foci as an indication for DNA double strand breaks. Results: (1) Heat exposure at 42 or 44 Degree-Sign C for 30 min induces gene amplification. The frequency of cad gene amplification increased by 2.8 and 6.5 folds respectively; (2) heat exposure at both 42 and 44 Degree-Sign C for 30 min induces DNA double strand breaks in HCT116 cells as shown by {gamma}H2AX immunostaining. Conclusion: This study shows that heat exposure can induce gene amplification in cancer cells, likely through the generation of DNA double strand breaks, which are believed to be required for the initiation of gene amplification. This process may be promoted by heat when cellular proteins that are responsible for checkpoints, DNA replication, DNA repair and telomere functions are denatured. To our knowledge, this is the first study to provide direct evidence of hyperthermia induced gene amplification.

Yan, Bin, E-mail: yanbin@mercyhealth.com [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States) [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States); Mercy Cancer Center, Mercy Medical Center-North Iowa, Mason City, IA 50401 (United States); Ouyang, Ruoyun [Department of Respiratory Medicine, The Second Xiangya Hospital, Xinagya School of Medicine, Central South University, Changsha 410011 (China)] [Department of Respiratory Medicine, The Second Xiangya Hospital, Xinagya School of Medicine, Central South University, Changsha 410011 (China); Huang, Chenghui [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States) [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States); Department of Oncology, The Third Xiangya Hospital, Xinagya School of Medicine, Central South University, Changsha 410013 (China); Liu, Franklin [Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 (United States)] [Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 (United States); Neill, Daniel [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States)] [Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS 39213 (United States); Li, Chuanyuan [Dermatology, Duke University Medical Center, Durham, NC 27710 (United States)] [Dermatology, Duke University Medical Center, Durham, NC 27710 (United States); Dewhirst, Mark [Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 (United States)] [Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710 (United States)

2012-10-26T23:59:59.000Z

370

Calcium Phosphate Transfection Works very well for 293 cells (up to 95% transfection efficiencies). Grow cells in  

E-Print Network (OSTI)

into suitable volumes). 3. Prepare CaCl2/HBS/DNA precipitate: For each 10 cm dish, aliquot 0.5 ml 2X HBS of 2M CaCl2 and enough distilled water to bring the total volume to 0.5 ml (5 µg, 22 ul and 0.36 ml totalvolume for a 6 cm dish). Add the CaCl2/DNA mix to the HBS slowly with a P1000 pipette, mixing gently

Lamond, Angus I.

371

Finding a gene in a haystack  

Science Journals Connector (OSTI)

... the size of sample, double or triple samples can be processed simultaneously. Packaged under cleanroom conditions, Gene Frame II can be autoclaved and sterilized by ultraviolet irradiation. The adhesives ...

1997-02-27T23:59:59.000Z

372

Horizontal gene transfer in Bacteroides fragilis   

E-Print Network (OSTI)

Horizontal gene transfer (HGT) is one of the man driving forces of evolution in prokaryotes, and can also promote within-strain variation of bacterial species. The genomes of three previously sequenced Bacteroides fragilis ...

Jobling, Kelly Louise

2014-11-27T23:59:59.000Z

373

Validation of Gene Therapy Manufacturing Processes  

Science Journals Connector (OSTI)

Specific issues of concern in the validation of gene therapy viral vector manufacturing processes include quality of raw materials, safety testing of cell and viral banks, production and purification of the ve...

Dominick Vacante; Gail Sofer; Stephen Morris…

2002-01-01T23:59:59.000Z

374

Post transcriptional regulation of chloroplast gene expression by nuclear encoded gene products  

SciTech Connect

Many individual chloroplast genes require the products of a collection of nuclear genes for their successful expression. These nuclear gene products apparently work with great specificity, each committed to the expression of a single chloroplast gene. We have chosen as a model nuclear mutants of Chlamydomonas affected in different stages in the expression of the chloroplast encoded Photosystem II polypeptide, D2. We have made the progress in understanding how nuclear gene products affect the translation of the D2 encoding MRNA. Two nuclear genes are required for this process which have been mapped genetically. In contrast to other examples of nuclear control of translation in the chloroplast, these nuclear gene products appear to be required either for specific stages in translation elongation or for the post-translational stabilization of the nascent D2 protein. Pseudoreversion analysis has led us to a locus which may be directly involved in D2 expression. We have made considerable progress in pursuing the molecular basis of psbd MRNA stabilization. psbD 5' UTR specific transcripts have been synthesized in vitro and used in gel mobility shift assays. UV-crosslinking studies are underway to identify the transacting factors which bind to these sequences. The continued examination of these mutants will help us to understand how nuclear gene products work in this specific case of chloroplast gene expression, and will elucidate how two distinct genomes can interact generally.

Kuchka, M.R.

1992-01-01T23:59:59.000Z

375

GenePRIMP: A GENE PRediction IMprovement Pipeline for Prokaryotic genomes  

E-Print Network (OSTI)

PRediction IMprovement Pipeline for Amrita Pati 1 , NataliaGene Prediction IMprovement Pipeline, http://geneprimp.jgi-based post-processing pipeline that identifies erroneously

Pati, Amrita

2012-01-01T23:59:59.000Z

376

New Window Technology Saves Energy and the View | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

New Window Technology Saves Energy and the View New Window Technology Saves Energy and the View New Window Technology Saves Energy and the View November 5, 2013 - 3:55pm Addthis Researchers at the Energy Department's National Renewable Energy Laboratory are developing innovative new window technology that helps improve occupants' comfort and cuts energy use. | Photo courtesy of Pat Corkery, NREL. Researchers at the Energy Department's National Renewable Energy Laboratory are developing innovative new window technology that helps improve occupants' comfort and cuts energy use. | Photo courtesy of Pat Corkery, NREL. Gabrial Boeckman NREL Communications Manager for Buildings & Communities What does this project do? With funding from the Energy Department, the National Renewable Energy Laboratory is working to develop innovative insulating window film

377

Transmission Asset Optimization (and) A Contrarian View of the Future of  

NLE Websites -- All DOE Office Websites (Extended Search)

Transmission Asset Optimization (and) A Contrarian View of the Future of Transmission Asset Optimization (and) A Contrarian View of the Future of Distributed Generation vs. Central Station Generation Speaker(s): Dale Bradshaw Date: June 5, 2000 - 10:00am Location: 90-3148 Seminar Host/Point of Contact: David Faulkner This was a two part seminar: Part One: Transmission Asset Optimization Presentation of latest technology developments that can increase the flow of power over todays transmission lines, thus potentially reducing total costs for transmitting power, while improving transmission reliability. Technologies discussed include FACTs devices, energy storage, etc.) Part Two: A Contrarian View of the Future of Distributed Generation vs. Central Station Generation: There have been a lot claims and hype concerning the relative competitive position in the future of distributed generation (DG)

378

Photo of the Week: Satellite View of Sandy at Night | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Photo of the Week: Satellite View of Sandy at Night Photo of the Week: Satellite View of Sandy at Night Photo of the Week: Satellite View of Sandy at Night November 2, 2012 - 10:21am Addthis On Monday, October 29, 2012, Hurricane Sandy made landfall 5 miles south of Atlantic City, New Jersey, with maximum sustained winds near 80 mph. This satellite image was taken 16 to 18 hours before Sandy's landfall on the New Jersey coast, using the Visible Infrared Imaging Radiometer Suite on NASA's Suomi National Polar-orbiting Partnership satellite. The Department of Energy, in partnership with the Federal Emergency Management Administration (FEMA) and other federal agencies, is working around the clock to support the states and utilities that have been impacted by Sandy. Learn more about federal efforts to support utility power restoration. | Photo courtesy of CIMSS/University Wisconsin-Madison/NASA/NOAA.

379

DOE Seeks Public Views On How Best To Streamline Existing Regulations |  

NLE Websites -- All DOE Office Websites (Extended Search)

Public Views On How Best To Streamline Existing Public Views On How Best To Streamline Existing Regulations DOE Seeks Public Views On How Best To Streamline Existing Regulations January 31, 2011 - 5:53pm Addthis The Department of Energy today announced two immediate steps to implement the Obama Administration's Executive Order on Improving Regulation and Regulatory Review, which directs federal agencies to review existing regulations and determine whether they are still necessary and crafted effectively to solve current problems. First, to engage the public in a transparent review process, the Department is issuing a Request for Information asking the public how best to streamline existing regulations and to identify rules that are obsolete, unnecessary, unjustified, or simply no longer make sense. All comments and reply

380

DOE Seeks Public Views On How Best To Streamline Existing Regulations |  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

DOE Seeks Public Views On How Best To Streamline Existing DOE Seeks Public Views On How Best To Streamline Existing Regulations DOE Seeks Public Views On How Best To Streamline Existing Regulations January 31, 2011 - 5:53pm Addthis The Department of Energy today announced two immediate steps to implement the Obama Administration's Executive Order on Improving Regulation and Regulatory Review, which directs federal agencies to review existing regulations and determine whether they are still necessary and crafted effectively to solve current problems. First, to engage the public in a transparent review process, the Department is issuing a Request for Information asking the public how best to streamline existing regulations and to identify rules that are obsolete, unnecessary, unjustified, or simply no longer make sense. All comments and reply

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


381

New Window Technology Saves Energy and the View | Department of Energy  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

New Window Technology Saves Energy and the View New Window Technology Saves Energy and the View New Window Technology Saves Energy and the View November 5, 2013 - 3:55pm Addthis Researchers at the Energy Department's National Renewable Energy Laboratory are developing innovative new window technology that helps improve occupants' comfort and cuts energy use. | Photo courtesy of Pat Corkery, NREL. Researchers at the Energy Department's National Renewable Energy Laboratory are developing innovative new window technology that helps improve occupants' comfort and cuts energy use. | Photo courtesy of Pat Corkery, NREL. Gabrial Boeckman NREL Communications Manager for Buildings & Communities What does this project do? With funding from the Energy Department, the National Renewable Energy Laboratory is working to develop innovative insulating window film

382

3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone at the  

NLE Websites -- All DOE Office Websites (Extended Search)

3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone 3D View Inside the Skeleton with X-ray Microscopy: Imaging Bone at the Nanoscale Scientists studying osteoporosis and other skeletal diseases are interested in the 3D structure of bone and its responses to conditions such as weightlessness, radiation (of particular interest to astronauts) and vitamin D deficiency. The current gold standard, micro-computed tomography (micro-CT), provides 3D images of trabeculae, the small interior struts of bone tissue, and electron microscopy can provide nanometer resolution of thin tissue slices. Hard X-ray transmission microscopy has provided the first 3D view of bone structure within individual trabeculae on the nanoscale. figure 1 Figure 1 Micro-CT (left) shows trabecular structure inside of bone. Transmission X-ray microscopy (TXM; center and right) can reveal localized details of osteocyte lacunae and their processes.

383

Valley View Hot Springs Pool & Spa Low Temperature Geothermal Facility |  

Open Energy Info (EERE)

Valley View Hot Springs Pool & Spa Low Temperature Geothermal Facility Valley View Hot Springs Pool & Spa Low Temperature Geothermal Facility Facility Valley View Hot Springs Sector Geothermal energy Type Pool and Spa Location Villa Grove, Colorado Coordinates 38.248999°, -105.948608° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[]}

384

A tangentially viewing fast ion D-alpha diagnostic for NSTX  

SciTech Connect

A second fast ion D-alpha (FIDA) installation is planned at NSTX to complement the present perpendicular viewing FIDA diagnostics. Following the present diagnostic scheme, the new diagnostic will consist of two instruments: a spectroscopic diagnostic that measures fast ion spectra and profiles at 16 radial points with 5-10 ms resolution and a system that uses a band pass filter and photomultiplier to measure changes in FIDA light with 50 kHz sampling rate. The new pair of FIDA instruments will view the heating beams tangentially. The viewing geometry minimizes spectral contamination by beam emission or edge sources of background emission. The improved velocity-space resolution will provide detailed information about neutral-beam current drive and about fast ion acceleration and transport by injected radio frequency waves and plasma instabilities.

Bortolon, A.; Heidbrink, W. W. [University of California, Irvine, California 92697 (United States); Podesta, M. [Princeton Plasma Physics Laboratory, Princeton, New Jersey 08543 (United States)

2010-10-15T23:59:59.000Z

385

The Humboldt House-Rye Patch Geothermal District: An Interim View | Open  

Open Energy Info (EERE)

The Humboldt House-Rye Patch Geothermal District: An Interim View The Humboldt House-Rye Patch Geothermal District: An Interim View Jump to: navigation, search OpenEI Reference LibraryAdd to library Conference Paper: The Humboldt House-Rye Patch Geothermal District: An Interim View Abstract The Humboldt House - Rye Patch Geothermal District extends about 6 miles along the northwestern flank of the Humboldt Range in Pershing County, Nevada and is composed of a number of geothermal cells. The northern Humboldt House portion of the district hosts hot wells and silicic sinter deposits extending from within the Humboldt Range, westward for at least four miles, out into the Humboldt River Valley. The southern Rye Patch portion of the District has scant surface geothermal features, and is identified from well data. Exploration in the District in the mid to late

386

Gene Expression and Regulation from the p7 Promoter of Aedes Densonucleosis Virus  

Science Journals Connector (OSTI)

...for 60 min, 300 mul of light emission accelerator was added, and the sample was immediately...Ci/mmol, 10 mCi/ml; New England Nuclear) riboprobes from p7lacZ and pBGUS templates...transfection was lyophilized in a SpeedVac vacuum desiccator (Savant Instruments, Holbrook...

Michael W. Kimmick; Boris N. Afanasiev; Barry J. Beaty; Jonathan O. Carlson

1998-05-01T23:59:59.000Z

387

View and download all Security Smarts for your safety and security meetings  

NLE Websites -- All DOE Office Websites (Extended Search)

View and download all Security Smarts for your safety and security meetings View and download all Security Smarts for your safety and security meetings http://int.lanl.gov/security/documents/index.shtml#security-smarts Note: Security Smarts are current as of the date of publication. SecuritySmart Proof of United States Citizenship for the Badge Office The Badge Office is required by law to verify US citizenship. The following lists the acceptable documents that individuals can bring to the Badge Office. Native-born US Citizens Primary Evidence For an individual born in the United States, a current United States passport or a birth

388

Supreme Court Arguments on the ACA — A Clash of Two World Views  

Science Journals Connector (OSTI)

...adverse selection that results from requiring insurers to cover people with preexisting conditions. According to Scalia, that's "a self-created problem" that Congress could avoid by simply not requiring guaranteed issue of insurance and community risk rating. But Scalia seemed to take a different view... Supreme Court oral arguments may reveal the justices' views of fundamental political and social issues — including, in the case of the Affordable Care Act, what it means to ensure liberty and where the proper balance lies between judicial activism and deference to Congress.

Hall M.A.

2012-04-19T23:59:59.000Z

389

Under-Sodium Viewing: A Review of Ultrasonic Imaging Technology for Liquid Metal Fast Reactors  

SciTech Connect

This current report is a summary of information obtained in the "Information Capture" task of the U.S. DOE-funded "Under Sodium Viewing (USV) Project." The goal of the multi-year USV project is to design, build, and demonstrate a state-of-the-art prototype ultrasonic viewing system tailored for periodic reactor core in-service monitoring and maintenance inspections. The study seeks to optimize system parameters, improve performance, and re-establish this key technology area which will be required to support any new U.S. liquid-metal cooled fast reactors.

Griffin, Jeffrey W.; Peters, Timothy J.; Posakony, Gerald J.; Chien, Hual-Te; Bond, Leonard J.; Denslow, Kayte M.; Sheen, Shuh-Haw; Raptis, Paul

2009-03-27T23:59:59.000Z

390

Reverse Engineering and Analysis of Genome-Wide Gene Regulatory Networks from Gene Expression Profiles Using High-Performance Computing  

Science Journals Connector (OSTI)

Regulation of gene expression is a carefully regulated phenomenon in the cell. "Reverse-engineering” algorithms try to reconstruct the regulatory interactions among genes from genome-scale measurements of gene expression profiles (microarrays). ... Keywords: Reverse engineering, gene regulatory network, clustering algorithm, parallel computing.

Vincenzo Belcastro; Francesco Gregoretti; Velia Siciliano; Michele Santoro; Giovanni D'Angelo; Gennaro Oliva; Diego di Bernardo

2012-05-01T23:59:59.000Z

391

Identifying subtle interrelated changes in functional gene categories using continuous measures of gene expression  

Science Journals Connector (OSTI)

......lists of genes with EASE. Genome Biol. 4 R70 Liu, G., Loraine, A.E., Shigeta, R., Cline, M., Cheng, J., Valmeekam...of genes with EASE. Genome Biol., 4, R70. Liu,G., Loraine,A.E., Shigeta,R., Cline,M., Cheng,J., Valmeekam......

Yoram Ben-Shaul; Hagai Bergman; Hermona Soreq

2005-04-01T23:59:59.000Z

392

Gene Expression Analyses and Association Studies of Wood Development Genes in Loblolly Pine (Pinus taeda L.)  

E-Print Network (OSTI)

for the selected genes of this project. 4 Genetic variation in pines has been studied extensively because of a high level of variation in natural populations (Hamrick and Godt 1996; Ledig 1998). Gene expression analysis is a valuable tool for generating...

Palle, Sreenath Reddy

2011-10-21T23:59:59.000Z

393

Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma  

DOE Patents (OSTI)

A method for treatment of breast cancer and other types of cancer. The method comprises targeting and modulating Id-1 gene expression, if any, for the Id-1 gene, or gene products in breast or other epithelial cancers in a patient by delivering products that modulate Id-1 gene expression. When expressed, Id-1 gene is a prognostic indicator that cancer cells are invasive and metastatic.

Desprez, Pierre-Yves; Campisi, Judith

2014-08-19T23:59:59.000Z

394

News & Views ISSN 1746-075110.2217/RME.13.31 2013 Future Medicine Ltd Regen. Med. (2013) 8(4), 409412 409  

E-Print Network (OSTI)

News & Views ISSN 1746-075110.2217/RME.13.31 © 2013 Future Medicine Ltd Regen. Med. (2013) 8(4), 409­412 409 News & ViewsNews & ViewsNews & Views What first brought you from the engineering

Zandstra, Peter W.

395

A CSP View on UMLRT structure diagrams Clemens Fischer, ErnstRudiger Olderog and Heike Wehrheim  

E-Print Network (OSTI)

A CSP View on UML­RT structure diagrams Clemens Fischer, Ernst­R¨udiger Olderog and Heike Wehrheim UML­RT structure diagrams together with the formal method CSP­OZ combining CSP and Object­Z. While CSP­OZ is used for specifying the system components themselves (by CSP­OZ classes), UML­RT diagrams provide

Habel, Annegret

396

nature materials | VOL 9 | MAY 2010 | www.nature.com/naturematerials 379 news & views  

E-Print Network (OSTI)

and lubrication. They are highly resistant to chemical degradation and oxidation whereas their mechanicalnature materials | VOL 9 | MAY 2010 | www.nature.com/naturematerials 379 news & views C arbon and thermal properties. Combining carbon with its neighbouring atoms in the periodic table (boron and nitrogen

397

DROPLET CONDENSATION IN THE ISING MODEL: MODERATE DEVIATIONS POINT OF VIEW  

E-Print Network (OSTI)

DROPLET CONDENSATION IN THE ISING MODEL: MODERATE DEVIATIONS POINT OF VIEW ROLAND L. DOBRUSHIN 1 of microscopic droplets into a macro­ scopic one is studied for the case of the #­dimensional Ising model place. Key words: Large deviations, moderate deviations, Ising model, droplet. 1. Introduction

Grimmett, Geoffrey

398

Branching processes in random environment a view on critical and subcritical cases  

E-Print Network (OSTI)

Branching processes in random environment ­ a view on critical and subcritical cases M. Birkner1 environment. Then the transition from subcriticality to supercriticality proceeds in several steps, and there occurs a second `transition' in the subcritical phase (besides the phase-transition from (sub)criticality

Birkner, Matthias

399

NATURE PHYSICS | VOL 9 | OCTOBER 2013 | www.nature.com/naturephysics 605 news & views  

E-Print Network (OSTI)

NATURE PHYSICS | VOL 9 | OCTOBER 2013 | www.nature.com/naturephysics 605 news & views R ight after -- will then form. In our example, will have to change from +1 to -1, necessarily passing through zero as quantum phase transitions. The dependence of the number of defects on the cooling rate is governed

Loss, Daniel

400

NATURE PHYSICS | VOL 7 | DECEMBER 2011 | www.nature.com/naturephysics 927 news & views  

E-Print Network (OSTI)

NATURE PHYSICS | VOL 7 | DECEMBER 2011 | www.nature.com/naturephysics 927 news & views interactions a snapshot of the radial velocities induced when a 1022 g PBH passes through the Sun on a radial orbit. Unless the dark-matter density in the solar neighbourhood is significantly higher than expected, the rate

Loss, Daniel

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


401

VIEWS ON U.S. WATER RESEARCH AND TECHNOLOGY TRANSFER PROGRAMS  

E-Print Network (OSTI)

#12;VIEWS ON U.S. WATER RESEARCH AND TECHNOLOGY TRANSFER PROGRAMS By MAMADOU H. WATT, Director . . . . . . . . . . 18 5. Technology Transfer and Information Dissemination . . . . 20 5.1 Definition and Purpose. . . . . . . . . . . . . . . 20 5.2 The Process of Technology Transfer. . . . . . . . . 21 5.3 Products of Technology Transfer

District of Columbia, University of the

402

88 PART 2 LANDSCAPE DESIGN GUIDELINES AND PRECINCT PLANS View of Bailey Plaza looking North  

E-Print Network (OSTI)

of the future parcel north of Bailey Hall could become an important public space with long unobstructed views vistas from the Ag Quad to the west, restoring the original condition of this important space and its ANDREW DICKSON WHITE HOUSE FARRAND GARDEN BIG RED BARN KROCH LIBRARY OLIN LIBRARY SAGE CHAPEL DAY HALL

Keinan, Alon

403

Prioritization of fish assemblages with a view to conservation and restoration on a large scale European  

E-Print Network (OSTI)

Prioritization of fish assemblages with a view to conservation and restoration on a large scale The hierarchical organization of important sites for the conservation or the restoration of fish communities, we developed a methodology, which is easy to implement in different locations. Based on the fish

Paris-Sud XI, Université de

404

Self-Organizing Referral Networks: A Process View of Trust and Authority  

E-Print Network (OSTI)

Self-Organizing Referral Networks: A Process View of Trust and Authority Pinar Yolum Munindar P based on refer- ral systems, where agents adaptively give referrals to one another to find other trustworthy agents. Interestingly, referral systems provide us with a useful and intuitive model of how links

405

NEWS & VIEWS nature physics | VOL 4 | NOVEMBER 2008 | www.nature.com/naturephysics 835  

E-Print Network (OSTI)

NEWS & VIEWS nature physics | VOL 4 | NOVEMBER 2008 | www.nature.com/naturephysics 835 consequences of theoretical physics where reductions are necessary and perturbations ubiquitous. And where gadgets don't work. & Terhal, B. M. Phys. Rev. Lett. 101, 070503 (2008). 2. Kempe, J., Kitaev, A. & Regev, O. SIAM J. Comput

Loss, Daniel

406

246 NATURE PHYSICS | VOL 10 | APRIL 2014 | www.nature.com/naturephysics news & views  

E-Print Network (OSTI)

246 NATURE PHYSICS | VOL 10 | APRIL 2014 | www.nature.com/naturephysics news & views millikelvin and Computer Engineering and the Department of Physics, National University of Singapore, Singapore 117583, Singapore, and the Department of Physics, National University of Singapore, Singapore 117551, Singapore. e

Loss, Daniel

407

Understanding the influence of information systems competencies on process innovation: A resource-based view  

Science Journals Connector (OSTI)

The resource based view of firms is used to explore how information system (IS) competencies affect process innovation in an organization. Data was collected through a case study of two process innovations at a healthcare firm in the United States. The ... Keywords: Case study, Healthcare, Information systems competencies, Process innovation, Resource based theory

Monideepa Tarafdar; Steven R. Gordon

2007-12-01T23:59:59.000Z

408

Mobile Identity Management: An Enacted View George Roussos, Don Peterson, and Uma Patel  

E-Print Network (OSTI)

Mobile Identity Management: An Enacted View George Roussos, Don Peterson, and Uma Patel Abstract. Growth of mobile business requires the ability to provide context aware services when and where needed telephony networks and consumer electronics, which brings mobile business to the forefront. In this context

Roussos, George

409

A linear logical view of linear type isomorphisms Vincent Balat and Roberto Di Cosmo  

E-Print Network (OSTI)

A linear logical view of linear type isomorphisms Vincent Balat and Roberto Di Cosmo LIENS ' Ecole lambda calculus) have recently been investigated due to their practical interest in library search, where they provide a means to search functions by type (see [18, 19, 17, 20, 9, 8, 10]) and to match

Balat, Vincent - Laboratoire Preuves, Programmes et Systèmes, Université Paris 7

410

Critical issues and current views on teaching basic circuits and systems in electrical engineering education  

E-Print Network (OSTI)

education Joos Vandewalle Department of Electrical Engineering (ESAT) Katholieke Universiteit Leuven B-3001, its impact in the electrical engineering education and in order to increase the intrinsic interestCritical issues and current views on teaching basic circuits and systems in electrical engineering

411

A Hybrid Control Approach to the Next-Best-View Problem using Stereo Vision  

E-Print Network (OSTI)

A Hybrid Control Approach to the Next-Best-View Problem using Stereo Vision Charles Freundlich with motion planning results in a hybrid system, which we illustrate in computer simulations. I. INTRODUCTION- side the controlled infrastructure of lab environments. Such environments, equipped with e.g., Vicon

Mordohai, Philippos

412

Fast Illumination-invariant Background Subtraction using Two Views: Error Analysis, Sensor Placement and Applications  

E-Print Network (OSTI)

Fast Illumination-invariant Background Subtraction using Two Views: Error Analysis, Sensor£ Abstract Background modeling and subtraction to detect new or moving objects in a scene is an important a detailed analysis of such errors. Then, we propose a sensor configuration that eliminates false de

Paragios, Nikos

413

U.S.-Japan Scientific Collaboration: A View from the National Science Foundation  

E-Print Network (OSTI)

: U.S.-Japan Scientific Collaboration: A View from the National Science Foundation Ms. Anne an overview of the National Science Foundation, the US government's basic science and engineering research.S. National Science Foundation (NSF) Tokyo Regional Office since August 2010. She joined NSFinMay2005as

Ejiri, Shinji

414

NATURE MATERIALS | VOL 13 | MAY 2014 | www.nature.com/naturematerials 435 news & views  

E-Print Network (OSTI)

-temperature resistance expected for ceramic materials. Toughening is evidenced by the increasing resistanceNATURE MATERIALS | VOL 13 | MAY 2014 | www.nature.com/naturematerials 435 news & views N ature designs materials as hierarchical architectures with complex composite structures spanning the nano

Ritchie, Robert

415

CARMEN INFORMATION Most instructors use Carmen, an online tool for students to view course materials, submit  

E-Print Network (OSTI)

Desk at 688-HELP (4357) or Julie Maurer, Program 60 Coordinator, at 614-292-8860 Ohio State UsernameCARMEN INFORMATION Most instructors use Carmen, an online tool for students to view course to your classlist and select "Enroll Selected Users." FOR INSTRUCTORS For Assistance: Contact the Help

416

N-View Human Silhouette Segmentation in Cluttered, Partially Changing Environments ,  

E-Print Network (OSTI)

,9,16]. We, thus, present an approach, which conjoins probabilistic 3d fusion and energy based level set multiple static views. These estimates are integrated into a level set approach to provide the final segmen, the segmentation is usually performed based on probabilities [5] or energy minimization, e.g. level set approaches

417

Automatic UAV Landing with Ground Target Maintained in the Field of View  

E-Print Network (OSTI)

Automatic UAV Landing with Ground Target Maintained in the Field of View Laurent Burlion and Henry de Plinval Abstract In this paper, a key feature for UAV visual servoing in automatic land- ing. First, a control law for UAV automatic landing is proposed. Then, the output con- straint method

418

Machine Ethics and Human Ethics: A Critical View Francesco Amigoni and Viola Schiaffonati  

E-Print Network (OSTI)

Machine Ethics and Human Ethics: A Critical View Francesco Amigoni and Viola Schiaffonati@elet.polimi.it Abstract The rapid changes in the relationship between humans and machines evidence a progressive delegation of some human activities to machines. Among those, there are not only physical activities but also

Amigoni, Francesco

419

Aviation Safety Reporting System 625 Ellis St. Suite 305 Mountain View California 94043  

E-Print Network (OSTI)

of the event. Those who work to improve aviation safety have long recognized that incident reporting fromAviation Safety Reporting System 625 Ellis St. Suite 305 Mountain View California 94043 Cabin Crew Safety Information Article Presented at the 17th International Aircraft Cabin Safety Symposium by Linda

420

NATURE PHYSICS | VOL 9 | JUNE 2013 | www.nature.com/naturephysics 325 news & views  

E-Print Network (OSTI)

of emission can be envisaged, and have even been observed to occur naturally in outer space and in planetaryNATURE PHYSICS | VOL 9 | JUNE 2013 | www.nature.com/naturephysics 325 news & views LASERS Amplified atmospheres1,2 . For instance, stellar gases are known to emit surprisingly strong radiation on certain

Loss, Daniel

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
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421

Pinlight displays: wide field of view augmented reality eyeglasses using defocused point light sources  

Science Journals Connector (OSTI)

We present a novel design for an optical see-through augmented reality display that offers a wide field of view and supports a compact form factor approaching ordinary eyeglasses. Instead of conventional optics, our design uses only two simple hardware ...

Andrew Maimone; Douglas Lanman; Kishore Rathinavel; Kurtis Keller; David Luebke; Henry Fuchs

2014-07-01T23:59:59.000Z

422

3-19 Urban Design Figure 3-9 Aerial View E Looking West  

E-Print Network (OSTI)

View F Looking North West #12;3-21 Urban Design Figure 3-11 Skyline and Massachusetts Avenue Gateway to careful site planning and transportation demand management. As the area has become more densely developed employed by TranSComm whose primary responsibilities include identifying and responding to transportation

Mohanty, Raj

423

The Universe Viewed in Gamma-Rays 1 STACEE Observations of Extra-galactic Sources  

E-Print Network (OSTI)

Mexico at the Na- tional Thermal Solar Test Facility (35 N, 107 W, 1700 m ASL). A plan view, University of Chicago, Chicago, IL 60637, USA Abstract The Solar Tower Atmospheric Cherenkov Effect research facility near Albuquerque NM, USA, to achieve a gamma-ray energy threshold below

Enomoto, Ryoji

424

A Survey of Spatial Data Mining Methods Databases and Statistics Point of Views  

E-Print Network (OSTI)

A Survey of Spatial Data Mining Methods Databases and Statistics Point of Views Karine Zeitouni PRi in common. KEYWORDS : Spatial Data Mining, Spatial Databases, Rules Induction, Spatial Statistics, Spatial data mining to spatial data. This recent technology is an extension of the data mining applied

Zeitouni, Karine

425

MAD Science Demonstration Proposal Title: A MAD view of the M 16 elephant trunks  

E-Print Network (OSTI)

MAD Science Demonstration Proposal Title: A MAD view of the M 16 elephant trunks Investigators of the large gas and dust columns (known as "elephant trunks") in the heart of the Eagle Nebula (M 16 columns, or "elephant trunks". These trunks were famously imaged by Hester et al. (1996, AJ, 111, 2349

Liske, Jochen

426

Novel Applications of LEDs for Energy Savings A Systems Level View  

E-Print Network (OSTI)

product (3 production lines @ 24x5) Hg Arc Lamp (300 W/in) 65% of energy in IR UV LED Array (150 WNovel Applications of LEDs for Energy Savings A Systems Level View Santa Barbara Summit on Energy in a Round Lighting Hole? · DC device in an AC Powered World · Cool light source with thermal management

Salama, Khaled

427

Panoramic-View-and Epipolar-Plane-Image Understandings for Street-Parking Vehicle Detection  

E-Print Network (OSTI)

Panoramic-View- and Epipolar-Plane- Image Understandings for Street-Parking Vehicle Detection variation from slope of detected edges, street-parking vehicles can be detected. In our experiments. Information about street-parking vehicles is useful for re-planning roads and traffic system. In Japan, street

Ikeuchi, Katsushi

428

NEWS & VIEWS 810 nature physics | VOL 2 | DECEMBER 2006 | www.nature.com/naturephysics  

E-Print Network (OSTI)

NEWS & VIEWS 810 nature physics | VOL 2 | DECEMBER 2006 | www.nature.com/naturephysics non optimal doping (p = 0.16) -- roughly by a factor 10 -- as does the superconducting gap 0 -- by a factor 6 al. Phys. Rev. Lett. 89, 147003 (2002). 5. Norman, M. R. in Handbook of Magnetism and Advanced

Loss, Daniel

429

Delamination Failures in Long-Term Field Aged PV Modules from Point of View of Encapsulant  

Energy.gov (U.S. Department of Energy (DOE))

This PowerPoint presentation was originally given by Tsuyoshi Shioda of Mitsui Chemicals, Inc. on Feb. 26, 2014 during the opening session of the 2013 NREL PV Module Reliability Workshop. It summarizes the study of long-term, field-aged photovoltaic modules with typical delamination failures from the point of view of the encapsulant.

430

Network Utilization: the Flow View Avinatan Hassidim, Danny Raz, Michal Segalov Ariel Shaqed  

E-Print Network (OSTI)

Network Utilization: the Flow View Avinatan Hassidim, Danny Raz, Michal Segalov Ariel Shaqed Google a substantial investment. Therefore, there is an economical drive to increase the utilization of network, the utilization of network components has a direct impact on the performance of the network and its resilience

Tomkins, Andrew

431

Reduced form electricity spot price modeling with a view towards spike risk  

E-Print Network (OSTI)

Reduced form electricity spot price modeling with a view towards spike risk Prof. Dr. Meyer. Februar 2010, 16:15 Uhr Seminarraum, LudwigstraÃ?e 33 I The recent deregulation of electricity markets has led to the creation of energy exchanges, where the electricity is freely traded. We study the most

Gerkmann, Ralf

432

Pathways for protein folding: is a "new view" needed? Vijay S Pande1  

E-Print Network (OSTI)

Pathways for protein folding: is a "new view" needed? Vijay S Pande1 , Alexander Yu Grosberg2 energy MG Molten globule Introduction How do proteins fold? While the thirty five years since Anfinsen has demonstrated the complexity of protein folding, the search continues for the general principles

Croquette, Vincent

433

Metric 3D Reconstruction and Texture Acquisition of Surfaces of Revolution from a Single Uncalibrated View  

Science Journals Connector (OSTI)

Image analysis and computer vision can be effectively employed to recover the three-dimensional structure of imaged objects, together with their surface properties. In this paper, we address the problem of metric reconstruction and texture acquisition ... Keywords: Index Terms- Surface of revolution, camera self-calibration, single-view 3D metric reconstruction, texture acquisition, projective geometry, image-based modeling.

Carlo Colombo; Alberto Del Bimbo; Federico Pernici

2005-01-01T23:59:59.000Z

434

3D-mesh models: view-based indexing and structural analysis  

E-Print Network (OSTI)

3D-mesh models: view-based indexing and structural analysis Mohamed Daoudi, Tarik Filali Ansary.daoudi@lifl.fr, tarik.filali@lifl.fr, julien.tierny@lifl.fr, jean-philippe.vandeborre@lifl.fr Abstract. 3D-mesh models applications, medical or military simulations, video games and so on. Indexing and analyzing these 3D data

Paris-Sud XI, Université de

435

Cauchy transforms of measures viewed as some functionals of Fourier transforms  

E-Print Network (OSTI)

Cauchy transforms of measures viewed as some functionals of Fourier transforms Zbigniew J. Jurek Urbanik ABSTRACT. The Cauchy transform of a positive measure plays an impor- tant role in complex analysis and more recently in so-called free probability. We show here that the Cauchy transform restricted

Jurek, Zbigniew J.

436

Cauchy transforms of measures viewed as some functionals of Fourier transforms #  

E-Print Network (OSTI)

Cauchy transforms of measures viewed as some functionals of Fourier transforms # Zbigniew J. Jurek Urbanik ABSTRACT. The Cauchy transform of a positive measure plays an impor­ tant role in complex analysis and more recently in so­called free probability. We show here that the Cauchy transform restricted

Jurek, Zbigniew J.

437

Multi-view modeling to support embedded systems engineering in SysML  

Science Journals Connector (OSTI)

Embedded systems engineering problems often involve many domains, each with their own experts and tools. To help these experts with analysis and decision making in their domain, it is desirable to present them with a view of the system that is tailored ...

Aditya A. Shah; Aleksandr A. Kerzhner; Dirk Schaefer; Christiaan J. J. Paredis

2010-01-01T23:59:59.000Z

438

Pacific Science, vol. 68, no. 3 February, 10, 2014 (Early view)  

E-Print Network (OSTI)

Pacific Science, vol. 68, no. 3 February, 10, 2014 (Early view) Shallow-water holothuroids (Echinodermata) of Yap, Federated States of Micronesia By Sun W. Kim*, Allison K. Miller, Catherine Brunson Island of Yap (Federated States of Micronesia). We collected 37 species of holothuroids, including 32

Xie,Jiang (Linda)

439

Geosemble Combines Satellite Views With Data By BOOYEON LEE -10/29/2007  

E-Print Network (OSTI)

Security. In recent months, the company has received grants from the National Science Foundation, DefenseGeosemble Combines Satellite Views With Data Resources By BOOYEON LEE - 10/29/2007 Los Angeles Business Journal Staff Thanks to Google Maps you can zoom onto a satellite image of just about any office

Valero-Cuevas, Francisco

440

A genomic view of introgression and hybrid speciation Eric J Baack1  

E-Print Network (OSTI)

A genomic view of introgression and hybrid speciation Eric J Baack1 and Loren H Rieseberg1,2 Hybridization in plants and animals is more common and has more complex outcomes than previously realized that a substantial fraction of their genomes are permeable to alleles from related species. Hybridization can lead

Rieseberg, Loren

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


441

X-ray absorption anisotropy for polychromatic illumination--Crystal views from inside  

E-Print Network (OSTI)

X-ray absorption anisotropy for polychromatic illumination--Crystal views from inside P. Korecki a Keywords: X-ray absorption Real-space imaging X-ray holography Electron channeling Electron backscatter of the fine structure in X-ray absorption anisotropy, which results from incident beam diffraction

Korecki, Pawe³

442

Ribeiro's typology, genomes, and Spanish colonialism, as viewed from Gran Canaria and Colombia  

E-Print Network (OSTI)

Ribeiro's typology, genomes, and Spanish colonialism, as viewed from Gran Canaria and ColombiaDNA as witness, and their autosome sets as new. Key words: Gran Canaria, Y-chromosome polymorphisms, admixture Palma, La Gomera, Fuente- ventura, Lanzarote and the main islands of Tenerife and Gran Canaria

443

NEWS & VIEWS nature physics | VOL 2 | JUNE 2006 | www.nature.com/naturephysics 377  

E-Print Network (OSTI)

energy level, producing a much smaller cloud. NaturePublishing Group©2006 #12;NEWS & VIEWS 378 nature to produce these important systems on a chip could also open the way to their practical use. JOHN E. THOMAS­Dirac particles are the basic building blocks of all matter, and the recently developed ability to trap

Loss, Daniel

444

Point of View and Zibun: Toward a Unified Theory of the Japanese Reflexive  

E-Print Network (OSTI)

. Accordingly, the binding theory of zibun along the lines of this view will take the form of disjunction: zibun is bound by an NP if the NP is the clause-mate subject or it is a logophoric NP. However, it is hard to accept the idea of a morpheme one use...

Yabushita, Katsuhiko

1995-01-01T23:59:59.000Z

445

A Dynamical Network View of Lyon's Velo'v Shared Bicycle System  

E-Print Network (OSTI)

A Dynamical Network View of Lyon's V´elo'v Shared Bicycle System Pierre Borgnat1 , C´eline Robardet@gmail.com Corresponding Authors Summary. Community shared bicycle systems are an instance of public trans- portation's shared bicycle system, called V´elo'v, can be seen as a dynamical complex network, and how using commu

Robardet, Céline

446

502 NATURE PHOTONICS | VOL 4 | AUGUST 2010 | www.nature.com/naturephotonics news & views  

E-Print Network (OSTI)

502 NATURE PHOTONICS | VOL 4 | AUGUST 2010 | www.nature.com/naturephotonics news & views I n 1924 a `saturated ideal gas'"1 . This ultimately led to one of the most important discoveries of the twentieth place in the spectrum of excited modes; these shrink in size and thus drive the overall lasing process

Fischer, Baruch

447

NEWS & VIEWS nature physics | VOL 2 | FEBRUARY 2006 | www.nature.com/naturephysics 77  

E-Print Network (OSTI)

NEWS & VIEWS nature physics | VOL 2 | FEBRUARY 2006 | www.nature.com/naturephysics 77 MAGNETIC Drive, West Lafayette, Indiana 47907, USA. e-mail: raftery@purdue.edu O ne of the most powerful aspects gas krypton-83 as such a contrast agent and show that it offers some unusual properties, especially

Loss, Daniel

448

NEWS & VIEWS nature physics | VOL 3 | JANUARY 2007 | www.nature.com/naturephysics 15  

E-Print Network (OSTI)

NEWS & VIEWS nature physics | VOL 3 | JANUARY 2007 | www.nature.com/naturephysics 15 QUANTUM. The fluctuations that drive quantum phase transitions are of a different nature from those at T > 0, so we expect are familiar from everyday life, with the liquid­gas transition from water to water vapour and the solid

Loss, Daniel

449

14 nature geoscience | VOL 2 | JANUARY 2009 | www.nature.com/naturegeoscience news & views  

E-Print Network (OSTI)

14 nature geoscience | VOL 2 | JANUARY 2009 | www.nature.com/naturegeoscience news & views's surface, as the eccentricity tide does, the obliquity tide can also drive a toroidal flow of the sub-oscillation period (or natural-sloshing period) of the Atlantic Ocean is near to 12 h, which is roughly the period

Waugh, Darryn W.

450

View Records  

NLE Websites -- All DOE Office Websites (Extended Search)

AES/MOM Feedback AES/MOM Feedback First Name Last Name E-Mail Comment Response Initials Date Bob Wilson wilson@aps.anl.gov I was called in on Sunday July 21. I had to go up to the control room to get the key so I could get into our tech room. My keys and other items I need to perform my work are at my desk so I must have access to it. The first guy in the control room didn't even know what I was talking about when I asked him for the key. Luckily a second person walked in as I was about to leave and he knew about the key. This senerio took a little over 30 minutes of time after I arrived at the lab. The problem I was called in for was ours so I'm sure that our group is charged with this downtime for the user. I don't understand why I don't have access to my own work area. I only have it if I ask someone to let me in. The talk around the APS is how we are all in a budget crisis. I'm told that we are eventually getting a card reader on one of the doors but the cost of that is in the neighborhood of $6,000.00. Why do we not all just get keys? It would save thousands of dollars and time in the event we are called in during off hours. I agree with you Bob. The installation delay for a badge card reader is due to the required parts not being available. This has now been resolved (I think) and Scheck can now go forward with the installation. Thanks for your patience with this annoying situation. Geo 2013-07-26 08:44:43

451

(for Gene Recognition Analysis Internet Link),  

NLE Websites -- All DOE Office Websites (Extended Search)

5 6/1/2011 5 6/1/2011 6.6 Speeding Up the Process of Gene Discovery The human genome contains information that could be used to prevent birth defects and treat or cure devastating diseases, but it is written in a language that scientists are only beginning to understand. To help decipher the code, Ed Uberbacher and colleagues at Oak Ridge National Laboratory combined cutting- edge computer technology with their knowledge of human biology to develop GRAIL (for Gene Recognition Analysis Internet Link), a "thinking" computer program that imitates the human learning process as it searches for genetic meaning. GRAIL and successor software programs can rapidly identify key instructions in genes from within vast stretches of DNA that appear to be meaningless-a critical contribution to the

452

Retroviral vectors for human gene delivery  

Science Journals Connector (OSTI)

The potential for gene therapy to cure a wide range of diseases has lead to high expectations and a great increase in research efforts in this area. At present, viral vectors are the most efficient means of delivering a corrective gene into human cells. While a number of different viral vectors are under development, retroviral vectors are currently the most common type used in clinical trials today. However, the production of retroviral vectors for gene therapy applications faces a number of challenges. Of primary concern is the low titre of vector stocks produced by packaging cells in culture and the inherent instability of retroviral vector activity. The problems facing large-scale retroviral vector production are outlined in this review and the research efforts by a number of groups who have attempted to optimise production methods are presented.

Sally McTaggart; Mohamed Al-Rubeai

2002-01-01T23:59:59.000Z

453

Regulation of methane genes and genome expression  

SciTech Connect

At the start of this project, it was known that methanogens were Archaeabacteria (now Archaea) and were therefore predicted to have gene expression and regulatory systems different from Bacteria, but few of the molecular biology details were established. The goals were then to establish the structures and organizations of genes in methanogens, and to develop the genetic technologies needed to investigate and dissect methanogen gene expression and regulation in vivo. By cloning and sequencing, we established the gene and operon structures of all of the “methane” genes that encode the enzymes that catalyze methane biosynthesis from carbon dioxide and hydrogen. This work identified unique sequences in the methane gene that we designated mcrA, that encodes the largest subunit of methyl-coenzyme M reductase, that could be used to identify methanogen DNA and establish methanogen phylogenetic relationships. McrA sequences are now the accepted standard and used extensively as hybridization probes to identify and quantify methanogens in environmental research. With the methane genes in hand, we used northern blot and then later whole-genome microarray hybridization analyses to establish how growth phase and substrate availability regulated methane gene expression in Methanobacterium thermautotrophicus ?H (now Methanothermobacter thermautotrophicus). Isoenzymes or pairs of functionally equivalent enzymes catalyze several steps in the hydrogen-dependent reduction of carbon dioxide to methane. We established that hydrogen availability determine which of these pairs of methane genes is expressed and therefore which of the alternative enzymes is employed to catalyze methane biosynthesis under different environmental conditions. As were unable to establish a reliable genetic system for M. thermautotrophicus, we developed in vitro transcription as an alternative system to investigate methanogen gene expression and regulation. This led to the discovery that an archaeal protein, designated TFE, that had sequences in common with the eukaryotic general transcription factor TFIIE, stimulated archaeal transcription initiation and that the archaeal TATA-box binding protein (TBP) remained attached to the promoter region whereas the transcription factor TFB dissociated from the template DNA following initiation. DNA sequences that directed the localized assembly of archaeal histones into archaeal nucleosomes were identified, and we established that transcription by an archaeal RNA polymerase was slowed but not blocked by archaeal nucleosomes. We developed a new protocol to purify archaeal RNA polymerases and with this enzyme and additional improvements to the in vitro transcription system, we established the template requirements for archaeal transcription termination, investigated the activities of proteins predicted to be methane gene regulators, and established how TrpY, a novel archaeal regulator of expression of the tryptophan biosynthetic operon functions in M. thermautotrophicus. This also resulted in the discovery that almost all M. thermautotrophicus mutants isolated as spontaneously resistant to 5-methyl tryptophan (5MTR) had mutations in trpY and were therefore 5MTR through de-repressed trp operon expression. This established a very simple, practical procedure to determine and quantify the DNA sequence changes that result from exposure of this Archaeon to any experimental mutagenesis protocol. Following the discovery that the Thermococcus kodakaraensis was amenable to genetic manipulation, we established this technology at OSU and subsequently added plasmid expression, a reporter system and additional genetic selections to the T. kodakaraensis genetic toolbox. We established that transcription and translation are coupled in this Archaeon, and by combining in vitro transcription and in vivo genetics, we documented that both TFB1 and TFB2 support transcription initiation in T. kodakaraensis. We quantified the roles of ribosome binding sequences and alternative initiation codons in translation initiation, established that polarity e

John N. Reeve

2009-09-09T23:59:59.000Z

454

Basidiomycete Mating Type Genes and Pheromone Signaling  

Science Journals Connector (OSTI)

...behavior and only a slight reduction of aerial hyphal formation were seen in the homokaryotic...and gpc genes, reduces the growth of aerial hyphae and, when homoallelic in a dikaryon...S. Fox, V. Grinberg, J. Fu, M. Fukushima, B. J. Haas, J. C. Huang, G. Janbon...

Marjatta Raudaskoski; Erika Kothe

2010-02-26T23:59:59.000Z

455

Expression of the MHC Class III Genes  

Science Journals Connector (OSTI)

...biosynthesis of the MHC class III products; for example...C2-producing cells is greater in freshly isolated macrophages...to expression of the class III MHC gene products...biosynthesis of the MHC class III products; for example...C2-producing cells is greater in freshly isolated macrophages...

1984-01-01T23:59:59.000Z

456

Inferring differentiation pathways from gene expression  

Science Journals Connector (OSTI)

......as finding the pdf p t [x] that...multivariate Gaussian pdf is defined (Cover...From genomics to chemical genomics: new...Som toolbox for matlab. In: Technical...Supplementary Data - pdf file Inferring...underlying molecular processes. In previous...physiology Computer Simulation Gene Expression......

Ivan G. Costa; Stefan Roepcke; Christoph Hafemeister; Alexander Schliep

2008-07-01T23:59:59.000Z

457

Should there be property rights in genes?  

Science Journals Connector (OSTI)

...whether large or small, can be `owned' in the same way as cars and houses, and so be subject to being bought and sold? Society...which produce them would be to prevent the transmission of defective genes to subsequent generations. Some would prohibit all such...

1997-01-01T23:59:59.000Z

458

Disentangling Mental Disorders : from Genes to Circuits  

E-Print Network (OSTI)

Summer Program 2014 Disentangling Mental Disorders : from Genes to Circuits RIKEN Brain Science Application : http://www.brain.riken.jp/en/summer/ Inquiries : info.summer@brain.riken.jp RIKEN Brain Science July 15-July 22, 2014 Summer Program 2014 Summer Program 2014 RIKEN Brain Science InstituteRIKEN Brain

Kazama, Hokto

459

Where are Functions in PRISM 11.5.10? File Edit View Folder Tools Inquire Window Help  

E-Print Network (OSTI)

Where are Functions in PRISM 11.5.10? File Edit View Folder Tools Inquire Window Help New Help Desk ­ 412624help Switch Responsibility #12; Undo Typing Show Navigator New Acceptances View Lines Cascade Window Help Open Cut Zoom Open

Sibille, Etienne

460

Video Navigation with a Personal Viewing History Abir Al-Hajri, Gregor Miller, Sidney Fels, and Matthew Fong  

E-Print Network (OSTI)

Video Navigation with a Personal Viewing History Abir Al-Hajri, Gregor Miller, Sidney Fels, Canada {abira, gregor, ssfels, mfong}@ece.ubc.ca Abstract. We describe a new video interface based previously viewed intervals, highlight segments of video the user found interesting and support other video

Millerm Gregor

Note: This page contains sample records for the topic "gene transfection view" from the National Library of EnergyBeta (NLEBeta).
While these samples are representative of the content of NLEBeta,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of NLEBeta
to obtain the most current and comprehensive results.


461

E-Print Network 3.0 - acid metabolism-related genes Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

attempt... Genes in the environment Genes and Ecosystems Dr Eshwar Mahenthiralingam (Esh) Cardiff University... 12;Genes in the environment Ecosystems (food, medicine, soil...

462

E-Print Network 3.0 - atctl2 gene enhances Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

Genes in the environment Genes and Ecosystems Dr Eshwar Mahenthiralingam (Esh) Cardiff University... 12;Genes in the environment Ecosystems (food, medicine, soil...

463

E-Print Network 3.0 - antifreeze protein gene Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

and nuclear gene sequences Summary: ribosomal protein intron 1), and combined dataset containing the mtDNA and nuclear genes resulted... complete gene sequences from...

464

E-Print Network 3.0 - atherosclerosis gene expression Sample...  

NLE Websites -- All DOE Office Websites (Extended Search)

Gene Sequences In Drosophila melanogaster... , USA We performed a systematic BLAST analysis of 929 human disease gene entries associated... disease genes (77% of disease...

465

E-Print Network 3.0 - animal gene families Sample Search Results  

NLE Websites -- All DOE Office Websites (Extended Search)

a curated database of phylogenetic trees of animal gene families... Fam: a curated database of phylogenetic trees of animal gene families 12,400 animal gene ... Source:...

466

E-Print Network 3.0 - akt-mediated gene repression Sample Search...  

NLE Websites -- All DOE Office Websites (Extended Search)

rapid reactivation of transcription, a phenomenon known... - scription results in gene looping. After repression, genes can remain looped through interac- tions... that gene...

467

Regulation of HIV-1 gene expression  

SciTech Connect

The quantity and quality of HIV-1 gene expression is temporally controlled by a cascade of sequential regulatory interactions. basal HIV-1 transcription is determined by interaction of cellular regulatory proteins with specific DNA target sequences within the HIV-1 long-terminal repeat. The most notable of these protein: DNA interactions involves NF-{aleph}B, a transcription factor that plays a pivotal role in the activation of genes important for cellular responses to infection and inflammation. A second level of control involves the virally encoded Tat trans-activator. Tat, in combination with as yet unidentified cellular proteins, activates HIV-1 gene expression through a specific interaction with the viral TAR RNA stem-loop target sequence. A final level of regulation is mediated by the viral Rev protein. Rev acts posttranscriptionally to induce the expression of HIV-1 structural proteins and thereby commits HIV-1 to the late, cytopathic phase of the viral replication cycle. Rev activity appears to require a critical, threshold level of Rev protein expression, thus preventing entry into this late phase in cells that are unable to support efficient HIV-1 gene expression. In total, this cascade of regulatory levels allow the HIV-1 provirus to respond appropriately to the intracellular milieu present in each infected cell. In activated cells, the combination of Tat and Rev can stimulate a very high level of viral gene expression and replication. In quiescent or resting cells, in contrast, these same regulatory proteins are predicted to maintain the HIV-1 provirus in a latent or nonproductive state.

Cullen, B.R. (Duke Univ., Durham, NC (United States))

1991-07-01T23:59:59.000Z

469

Abnormal Gene Expression of Four Genes in Cells from Family Members of  

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Abnormal Gene Expression of Four Genes in Cells from Family Members of Abnormal Gene Expression of Four Genes in Cells from Family Members of Hereditary-type Retinoblastoma Patients relative to Normal Individuals Chin-Yu Wang, 1 Yuanlin Peng, 1 Zhonghui Yang, 2 Chuan-Yuan Li, 2 Hatsumi Nagasawa, 1 Markus M. Fitzek, 3 John B. Little, 4 Joel S. Bedford, 1 and Eric Y. Chuang 5 1 Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado; 2 Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina; 3 Department of Radiation Oncology, Tufts-New England Medical Center; 4 Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts; and 5 Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan

470

E-Print Network 3.0 - allelic based gene-gene Sample Search Results  

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identify many common alleles of major effect... to that in humans7,8 , the resulting SNP density of one SNP per 500 base pairs is considerably higher than... number of genes (Fig....

471

Gene-supplemented collagen scaffolds for non-viral gene delivery for brain tissue engineering  

E-Print Network (OSTI)

Recent advances in tissue engineering, combining an extracellular matrix (ECM)-like vehicle with therapeutic molecules, cells and/or genes has yielded promising results for brain injury repair. The purpose of this thesis ...

Bolliet, Catherine

2007-01-01T23:59:59.000Z

472

Nonsyntenic Genes Drive Highly Dynamic Complementation of Gene Expression in Maize Hybrids  

Science Journals Connector (OSTI)

...Authors ( www.plantcell.org ) is: Frank Hochholdinger ( hochholdinger@uni-bonn.de ). [W] Online version contains Web-only data. This study analyzes how transcriptome diversity between two maize inbred lines affects gene expression patterns...

Anja Paschold; Nick B. Larson; Caroline Marcon; James C. Schnable; Cheng-Ting Yeh; Christa Lanz; Dan Nettleton; Hans-Peter Piepho; Patrick S. Schnable; Frank Hochholdinger

2014-10-14T23:59:59.000Z

473

FACET: a radiation view factor computer code for axisymmetric, 2D planar, and 3D geometries with shadowing  

SciTech Connect

The computer code FACET calculates the radiation geometric view factor (alternatively called shape factor, angle factor, or configuration factor) between surfaces for axisymmetric, two-dimensional planar and three-dimensional geometries with interposed third surface obstructions. FACET was developed to calculate view factors for input to finite-element heat-transfer analysis codes. The first section of this report is a brief review of previous radiation-view-factor computer codes. The second section presents the defining integral equation for the geometric view factor between two surfaces and the assumptions made in its derivation. Also in this section are the numerical algorithms used to integrate this equation for the various geometries. The third section presents the algorithms used to detect self-shadowing and third-surface shadowing between the two surfaces for which a view factor is being calculated. The fourth section provides a user's input guide followed by several example problems.

Shapiro, A.B.

1983-08-01T23:59:59.000Z

474

Mutational Analysis of the Wilms' Tumor (WTI) Gene  

Science Journals Connector (OSTI)

Mutations of the Wilms’ tumor (WT1) gene have been shown to underlie a proportion of cases of Wilms’ tumor, an embryonal kidney cancer occurring mainly in childhood. The WTl gene comprtses ten exons spanning a...

Linda King-Underwood; Kathy Pritchard-Jones

1996-01-01T23:59:59.000Z

475

Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes  

E-Print Network (OSTI)

Transcriptional regulation constrains the organization of genes on eukaryotic chromosomes Sarath. Although it is known that eukaryotic transcriptional regulation is complex and requires an intricate-order organization of genes across and within chromosomes that is constrained by transcriptional regulation

Babu, M. Madan

476

Undergraduate Research at Jefferson Lab - LabVIEW Software Based Program to  

NLE Websites -- All DOE Office Websites (Extended Search)

Data Acquisition Components Data Acquisition Components Previous Project (Data Acquisition Components) Undergraduate Research Main Index Next Project (Spin-Polarization of Helium-3 Target Cell) Spin-Polarization of Helium-3 Target Cell LabVIEW Software Based Program to Minimize Data File Size of the Slow Controls System (SCS) of the Silicon Vertex Tracker (SVT) Student: Zulqarnain M Jamal School: Georgia Institute of Technology Mentored By: Amrit Yegneswaran SVT is a detector, made of silicon modules. It tracks charged particles and helps to determine interaction vertices. SCS controls and monitors currents and voltages, and monitors temperatures and humidity. SCS produces large data files. Smart Logger, a LabVIEW program, has been developed in to minimize data file size. Smart Logger discards data-sets if any the

477

Grand View-on-Hudson, New York: Energy Resources | Open Energy Information  

Open Energy Info (EERE)

View-on-Hudson, New York: Energy Resources View-on-Hudson, New York: Energy Resources Jump to: navigation, search Equivalent URI DBpedia Coordinates 41.0639856°, -73.9204144° Loading map... {"minzoom":false,"mappingservice":"googlemaps3","type":"ROADMAP","zoom":14,"types":["ROADMAP","SATELLITE","HYBRID","TERRAIN"],"geoservice":"google","maxzoom":false,"width":"600px","height":"350px","centre":false,"title":"","label":"","icon":"","visitedicon":"","lines":[],"polygons":[],"circles":[],"rectangles":[],"copycoords":false,"static":false,"wmsoverlay":"","layers":[],"controls":["pan","zoom","type","scale","streetview"],"zoomstyle":"DEFAULT","typestyle":"DEFAULT","autoinfowindows":false,"kml":[],"gkml":[],"fusiontables":[],"resizable":false,"tilt":0,"kmlrezoom":false,"poi":true,"imageoverlays":[],"markercluster":false,"searchmarkers":"","locations":[{"text":"","title":"","link":null,"lat":41.0639856,"lon":-73.9204144,"alt":0,"address":"","icon":"","group":"","inlineLabel":"","visitedicon":""}]}

478

Most Viewed Documents - National Defense | OSTI, US Dept of Energy, Office  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - National Defense Most Viewed Documents - National Defense 2012 Monitoring Research Review: Ground-Based Nuclear Explosion Monitoring Technologies Wetovsky, Marvin A. [Los Alamos National Laboratory]; Anderson, Dale [Los Alamos National Laboratory]; Arrowsmith, Stephen J. [Los Alamos National Laboratory]; et al. (2012) Smart bridge: a tool for estimating the military load classification of bridges Van Groningen, C.N.; Paddock, R.A. (1997) The Effects of Nuclear Weapons Glasstone, Samuel (1964) Detonation and combustion of explosives: A selected bibliography Dobratz, B. [comp.] (1998) SMART BRIDGE: A tool for estimating the military load classification of bridges using varying levels of information Van Groningen, C.N.; Paddock, R.A. (1997) Current limiters Loescher, D.H. [Sandia National Labs., Albuquerque, NM (United States).

479

Most Viewed Documents - Engineering | OSTI, US Dept of Energy, Office of  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - Engineering Most Viewed Documents - Engineering Conduction heat transfer solutions VanSant, J.H. (1980) Lunar Wireless Power Transfer Feasibility Study Sheldon Freid, et al. (2008) Charpy impact test results on five materials and NIST verification specimens using instrumented 2-mm and 8-mm strikers Nanstad, R.K.; Sokolov, M.A. (1995) Heat transfer model of above and underground insulated piping systems Kwon, K.C. (1998) Stress analysis and evaluation of a rectangular pressure vessel. [For equipment for sampling Hanford tank radwaste] Rezvani, M.A.; Ziada, H.H. (Westinghouse Hanford Co., Richland, WA (United States)); Shurrab, M.S. (Westinghouse Savannah River Co., Aiken, SC (United States)) (1992) Damage identification and health monitoring of structural and mechanical systems from changes in their vibration characteristics: A

480

Most Viewed Documents - Fission and Nuclear Technologies | OSTI, US Dept of  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - Fission and Nuclear Technologies Most Viewed Documents - Fission and Nuclear Technologies Metals design handbook Betts, W.S. (1988) Estimation of gas leak rates through very small orifices and channels. [From sealed PuO/sub 2/ containers under accident conditions] Bomelburg, H.J. () Graphite design handbook Ho, F.H. (1988) Motor-operated valve (MOV) actuator motor and gearbox testing DeWall, K.; Watkins, J.C.; Bramwell, D. [Lockheed Idaho Technologies Co., Idaho Falls, ID (United States)] (1997) Environmental Aspects, Objectives and Targets Identification Process R. Green (2002) Flow-induced vibration of circular cylindrical structures Chen, S.S. (1985) System Definition and Analysis: Power Plant Design and Layout NONE (1996) Materials and design bases issues in ASME Code Case N-47 Huddleston, R.L.; Swindeman, R.W. (Oak Ridge National Lab., TN (United

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481

Questions and Answers - What is the modern view of the structure of the  

NLE Websites -- All DOE Office Websites (Extended Search)

Atoms without neutrons? Atoms without neutrons? Previous Question (Atoms without neutrons?) Questions and Answers Main Index Next Question (Charge of proton and neutron?) Charge of proton and neutron? What is the modern view of the structure of the atom? How are the protons different from neutrons? What are the differences between protons and electrons? There are several concepts that go into our modern view of the atom. I have listed five and they are all "modern" in the sense that they have been developed within the past century. [Concept 1] - Subatomic particles Proton: positive charge, mass is about 2000 times that of the electron Neutron: neutral or zero charge, mass is nearly the same as the proton Electron: negative charge Neutrino: neutral, massless (?) The neutrino is a relatively unknown particle, but plays an important role

482

Most Viewed Documents - Chemistry | OSTI, US Dept of Energy, Office of  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - Chemistry Most Viewed Documents - Chemistry Flammability characteristics of combustible gases and vapors. [249 refs] Zabetakis, M.G. (1964) Electrical conductivity measurements of aqueous electrolyte solutions at high temperatures and high pressures Ho, P.C.; Palmer, D.A. (1995) Aqueous electrolyte modeling in ASPEN PLUS{trademark} Bloomingburg, G.F. [Univ. of Tennessee, Knoxville, TN (United States). Dept. of Chemical Engineering]|[Oak Ridge National Lab., TN (United States)]; Simonson, J.M.; Moore, R.C.; et al. (1995) Vapor-liquid equilibria for nitric acid-water and plutonium nitrate-nitric acid-water solutions Maimoni, A. (1980) Reaction mechanisms in cellulose pyrolysis: a literature review Molton, P.M.; Demmitt, T.F. () Ultrasonic Sensor and Method of use Condreva, Kenneth J. (1999)

483

Most Viewed Documents - Geosciences | OSTI, US Dept of Energy, Office of  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - Geosciences Most Viewed Documents - Geosciences Temperature Profiles and Hydrologic Implications from the Nevada Test Site David Gillespie (2005) 3-D full waveform inversion of seismic data; Part I. Theory Lee, Ki Ha (2003) Drilling and coring methods that minimize the disturbance of cuttings, core, and rock formation in the unsaturated zone, Yucca Mountain, Nevada Hammermeister, D.P.; Blout, D.O.; McDaniel, J.C. (1985) CO{sub 2}-H{sub 2}O mixtures in the geologic sequestration of CO{sub 2}. I. Assessment and calculation of mutual solubilities from 12 to 100 degrees C and up to 600 bar Spycher, Nicolas; Pruess, Karsten; Ennis-King, Jonathan (2002) ADVANCED CHARACTERIZATION OF FRACTURED RESERVOIRS IN CARBONATE ROCKS: THE MICHIGAN BASIN James R. Wood; William B. Harrison (2002)

484

September 2013 Most Viewed Documents for Chemistry | OSTI, US Dept of  

Office of Scientific and Technical Information (OSTI)

September 2013 Most Viewed Documents for Chemistry September 2013 Most Viewed Documents for Chemistry Molecular catalytic hydrogenation of aromatic hydrocarbons and hydrotreating of coal liquids. Yang, Shiyong; Stock, L.M. (1996) 36 Flammability characteristics of combustible gases and vapors. [249 refs] Zabetakis, M.G. (1964) 35 Reaction mechanisms in cellulose pyrolysis: a literature review Molton, P.M.; Demmitt, T.F. (1977) 32 Nuclear magnetic resonance measurement of ammonia diffusion in dense solid-liquid slurries. Revision 1 Bobroff, S.; Phillips, R.J. [Univ. of California, Davis, CA (United States). Dept. of Chemical Engineering]; Shekarriz, A. [Pacific Northwest National Lab., Richland, WA (United States)] (1998) 30 Determination of NAD+ and NADH level in a Single Cell Under H2O2 Stress by Capillary Electrophoresis

485

April 2013 Most Viewed Documents for Environmental Sciences | OSTI, US Dept  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Environmental Sciences April 2013 Most Viewed Documents for Environmental Sciences Building a secondary containment system Broder, M.F. (1994) 144 Methods and opportunities in the recycling of rare earth based materials Ellis, T.W.; Schmidt, F.A.; Jones, L.L. (1994) 134 Ecological Screening Values for Surface Water, Sediment, and Soil Friday, G. P. (1999) 128 Ammonia usage in vapor compression for refrigeration and air-conditioning in the United States Fairchild, P.D.; Baxter, V.D. (1995) 124 SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE GENERATOR SETS. KRISHNA,C.R. (1999) 95 Atmospheric Chemistry and Greenhouse Gases Ehhalt, D.; Prather, M.; Dentener, F.; Derwent, R.; Dlugokencky, Edward J.; Holland, E.; Isaksen, I.; Katima, J.; Kirchhoff, V.; Matson, P.; Midgley, P.; Wang, M.; Berntsen, T.; Bey, I.; Brasseur, G.; Buja, L.; Collins, W.

486

September 2013 Most Viewed Documents for Biology And Medicine | OSTI, US  

Office of Scientific and Technical Information (OSTI)

September 2013 Most Viewed Documents for Biology And Medicine September 2013 Most Viewed Documents for Biology And Medicine Drug Retention Times Center for Human Reliability Studies (2007) 29 Oleoresin Capsicum toxicology evaluation and hazard review Archuleta, M.M. (1995) 27 SURVEY OF NOISE SUPPRESSION SYSTEMS FOR ENGINE GENERATOR SETS. KRISHNA,C.R. (1999) 27 Site-Directed Research and Development FY 2012 Annual Report , (2013) 27 Human radiation studies: Remembering the early years. Oral history of Donner Lab Administrator Baird G. Whaley, August 15, 1994 NONE (1995) 26 Degradation of high concentrations of glycols, antifreeze, and deicing fluids Strong-Gunderson, J.M.; Wheelis, S.; Carroll, S.L.; Waltz, M.D.; Palumbo, A.V. (1995) 24 Human radiation studies: Remembering the early years. Oral history of Dr. George Voelz, M.D., November 29, 1994

487

April 2013 Most Viewed Documents for National Defense | OSTI, US Dept of  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for National Defense April 2013 Most Viewed Documents for National Defense Vapor-liquid equilibria for nitric acid-water and plutonium nitrate-nitric acid-water solutions Maimoni, A. (1980) 95 SMART BRIDGE: A tool for estimating the military load classification of bridges using varying levels of information Van Groningen, C.N.; Paddock, R.A. (1997) 69 LLNL small-scale drop-hammer impact sensitivity test Simpson, L.R.; Foltz, M.F. (1995) 67 Comments on TNT Equivalence Cooper, P.W. (1994) 66 Background chemistry for chemical warfare agents and decontamination processes in support of delisting waste streams at the U.S. Army Dugway Proving Ground, Utah Rosenblatt, D.H.; Small, M.J.; Kimmell, T.A.; Anderson, A.W. (1996) 65 Weapon container catalog. Volumes 1 & 2 Brown, L.A.; Higuera, M.C. (1998)

488

April 2013 Most Viewed Documents for Materials | OSTI, US Dept of Energy,  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Materials April 2013 Most Viewed Documents for Materials Fatigue design curves for 6061-T6 aluminum Yahr, G.T. (1993) 554 Charpy impact test results on five materials and NIST verification specimens using instrumented 2-mm and 8-mm strikers Nanstad, R.K.; Sokolov, M.A. (1995) 534 Heat Treatment Procedure Qualification -- Final Technical Report Robert C. Voigt (2004) 488 The influence of grain size on the mechanical properties ofsteel Morris Jr., J.W. (2001) 356 Damage identification and health monitoring of structural and mechanical systems from changes in their vibration characteristics: A literature review Doebling, S.W.; Farrar, C.R.; Prime, M.B.; Shevitz, D.W. (1996) 246 Graphite design handbook Ho, F.H. (1988) 216 Mechanical properties and energy absorption characteristics of a

489

Most Viewed Documents - Physics | OSTI, US Dept of Energy, Office of  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - Physics Most Viewed Documents - Physics Computational procedures for determining parameters in Ramberg-Osgood elastoplastic model based on modulus and damping versus strain Ueng, Tzou-Shin; Chen, Jian-Chu. (1992) Analysis of Lithium-Ion Battery Degradation During Thermal Aging JUNGST,RUDOLPH G.; NAGASUBRAMANIAN,GANESAN; CRAFTS,CHRIS C.; et al. (2000) Plastic Gamma Sensors: An Application in Detection of Radioisotopes S. Mukhopadhyay (2003) Lithium literature review: lithium's properties and interactions Jeppson, D.W.; Ballif, J.L.; Yuan, W.W.; et al. (1978) Fire protection system operating experience review for fusion applications Cadwallader, L.C. (1995) Organic light emitting diodes (OLEDS) and OLED-based structurally integrated optical sensors Cai, Yuankun (2010)

490

September 2013 Most Viewed Documents for Geosciences | OSTI, US Dept of  

Office of Scientific and Technical Information (OSTI)

September 2013 Most Viewed Documents for Geosciences September 2013 Most Viewed Documents for Geosciences Fundamental Research on Percussion Drilling: Improved rock mechanics analysis, advanced simulation technology, and full-scale laboratory investigations Michael S. Bruno (2005) 35 Seismic design evaluation guidelines for buried piping for the DOE HLW Facilities Lin, Chi-Wen [Consultant, Martinez, CA (United States)]; Antaki, G. [Westinghouse Savannah River Co., Aiken, SC (United States)]; Bandyopadhyay, K. [Brookhaven National Lab., Upton, NY (United States)]; Bush, S.H. [Review & Synthesis Association, Richland, WA (United States)]; Costantino, C. [City Univ. of New York, New York, NY (United States)]; Kennedy, R. [RPK Structural Mechanics, Yorba Linda, CA (United States). Consultant] (1995) 29 Proceedings of the wellbore sampling workshop

491

September 2013 Most Viewed Documents for National Defense | OSTI, US Dept  

Office of Scientific and Technical Information (OSTI)

September 2013 Most Viewed Documents for National Defense September 2013 Most Viewed Documents for National Defense SMART BRIDGE: A tool for estimating the military load classification of bridges using varying levels of information Van Groningen, C.N.; Paddock, R.A. (1997) 34 Left-Wing Extremism: The Current Threat Karl A. Seger (2001) 28 The Elusive Coefficients of Thermal Expansion in PBX 9502 C.B. Skidmore; T.A. Butler; C.W. Sandoval (2003) 28 Background chemistry for chemical warfare agents and decontamination processes in support of delisting waste streams at the U.S. Army Dugway Proving Ground, Utah Rosenblatt, D.H.; Small, M.J.; Kimmell, T.A.; Anderson, A.W. (1996) 27 MineSeis -- A MATLAB{reg_sign} GUI program to calculate synthetic seismograms from a linear, multi-shot blast source model Yang, X. (1998) 26 Comments on TNT Equivalence

492

Most Viewed Documents - Materials | OSTI, US Dept of Energy, Office of  

Office of Scientific and Technical Information (OSTI)

Most Viewed Documents - Materials Most Viewed Documents - Materials Phase diagrams of the elements Young, D.A. (1975) Use of instrumented charpy tests to determine onset of upper-shelf energy Canonico, D.A.; Stelzman, W.J.; Berggren, R.G.; et al. (1975) Thermal and electrical conductivities and Seebeck coefficients of unirradiated and irradiated graphites from 300 to 1000 K Moore, J.P.; Graves, R.S.; McElroy, D.L. (1973) LITERATURE SURVEY ON DILUTE URANIUM ALLOYS FOR SANDIA BOOSTER CONCEPT TO SANDIA CORPORATION. Fackelmann, J.M.; Bauer, A.A.; Moak, D.P. (1969) Properties of chemical explosives and explosive simulants Dobratz, B.M. (1972) Review of x-ray diffraction studies in uranium alloys Yakel, H.L. (1973) Elevated-temperature true stress-tube strain tensile behavior of AISI Type 304 stainless steel

493

April 2013 Most Viewed Documents for Mathematics And Computing | OSTI, US  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Mathematics And Computing April 2013 Most Viewed Documents for Mathematics And Computing Publications in biomedical and environmental sciences programs, 1981 Moody, J.B. (comp.) (1982) 306 A comparison of risk assessment techniques from qualitative to quantitative Altenbach, T.J. (1995) 159 Lecture notes for introduction to safety and health Biele, F. (1992) 138 Analytical considerations in the code qualification of piping systems Antaki, G.A. (1995) 113 Process Equipment Cost Estimation, Final Report H.P. Loh; Jennifer Lyons; Charles W. White, III (2002) 93 PC-1D installation manual and user's guide Basore, P.A. (1991) 70 SMART BRIDGE: A tool for estimating the military load classification of bridges using varying levels of information Van Groningen, C.N.; Paddock, R.A. (1997) 69 Computational procedures for determining parameters in

494

April 2013 Most Viewed Documents for Engineering | OSTI, US Dept of Energy,  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Engineering April 2013 Most Viewed Documents for Engineering Charpy impact test results on five materials and NIST verification specimens using instrumented 2-mm and 8-mm strikers Nanstad, R.K.; Sokolov, M.A. (1995) 534 Heat Treatment Procedure Qualification -- Final Technical Report Robert C. Voigt (2004) 488 Conduction heat transfer solutions VanSant, J.H. (1980) 364 Damage identification and health monitoring of structural and mechanical systems from changes in their vibration characteristics: A literature review Doebling, S.W.; Farrar, C.R.; Prime, M.B.; Shevitz, D.W. (1996) 246 Lunar Wireless Power Transfer Feasibility Study Sheldon Freid, et al. (2008) 229 Heat transfer model of above and underground insulated piping systems Kwon, K.C. (1998) 201 SYNTHETIC SLING FAILURE - EVALUATIONS & RECOMMENDATIONS

495

April 2013 Most Viewed Documents for Physics | OSTI, US Dept of Energy,  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Physics April 2013 Most Viewed Documents for Physics Lithium literature review: lithium's properties and interactions Jeppson, D.W.; Ballif, J.L.; Yuan, W.W.; Chou, B.E. (1978) 123 Plastic Gamma Sensors: An Application in Detection of Radioisotopes S. Mukhopadhyay (2003) 85 Organic light emitting diodes (OLEDS) and OLED-based structurally integrated optical sensors Cai, Yuankun (2010) 83 White LED with High Package Extraction Efficiency Yi Zheng; Matthew Stough (2008) 79 Analysis of Lithium-Ion Battery Degradation During Thermal Aging JUNGST,RUDOLPH G.; NAGASUBRAMANIAN,GANESAN; CRAFTS,CHRIS C.; INGERSOLL,DAVID; DOUGHTY,DANIEL H. (2000) 74 Cathodic arc plasma deposition Anders, Andre (2002) 73 Energy level structure and transition probabilities in the spectra of the trivalent lanthanides in LaF/sub 3/. [Tables, diagrams]

496

April 2013 Most Viewed Documents for Geosciences | OSTI, US Dept of Energy,  

Office of Scientific and Technical Information (OSTI)

April 2013 Most Viewed Documents for Geosciences April 2013 Most Viewed Documents for Geosciences Sloshing analysis of viscous liquid storage tanks Uras, R.Z. (1995) 83 Seismic design evaluation guidelines for buried piping for the DOE HLW Facilities Lin, Chi-Wen [Consultant, Martinez, CA (United States)]; Antaki, G. [Westinghouse Savannah River Co., Aiken, SC (United States)]; Bandyopadhyay, K. [Brookhaven National Lab., Upton, NY (United States)]; Bush, S.H. [Review & Synthesis Association, Richland, WA (United States)]; Costantino, C. [City Univ. of New York, New York, NY (United States)]; Kennedy, R. [RPK Structural Mechanics, Yorba Linda, CA (United States). Consultant] (1995) 48 CO{sub 2}-H{sub 2}O mixtures in the geologic sequestration of CO{sub 2}. I. Assessment and calculation of mutual solubilities from 12 to 100

497

A Laser Metrology/Viewing System for ITER In-Vessel Inspection  

SciTech Connect

This paper identifies the requirements for a remotely operated precision laser ranging system for the International Thermonuclear Experimental Reactor. The inspection system is used for metrology and viewing, and must be capable of achieving submillimeter accuracy and operation in a reactor vessel that has high gamma radiation, high vacuum, elevated temperature, and magnetic field levels. A coherent, frequency modulated laser radar system is under development to meet these requirements. The metrology/viewing sensor consists of a compact laser-optic module linked through fiberoptics to the laser source and imaging units, located outside the harsh environment. The deployment mechanism is a remotely operated telescopic mast. Gamma irradiation up to 10{sup 7} Gy was conducted on critical sensor components with no significant impact to data transmission, and analysis indicates that critical sensor components can operate in a magnetic field with certain design modifications. Plans for testing key components in a magnetic field are underway.

Spampinato, P.T.; Barry, R.E.; Chesser, J.B.; Menon, M.M. [Oak Ridge National Lab., TN (United States); Dagher, M.A. [Boeing Rocketdyne Div., Canoga Park, CA (United States); Slotwinski, A. [Coleman Research Corp., Springfield, VA (United States)

1997-12-31T23:59:59.000Z

498

Progress of the ITER equatorial vis/IR wide angle viewing system optical design  

SciTech Connect

The equatorial vis/IR wide angle viewing system is present in four ITER diagnostic equatorial ports. This instrument will cover a large field of view with high spatial and temporal resolutions, to provide real time temperature measurements of plasma facing components, spectral data in the visible range, information on runaway electrons, and pellet tracking. This diagnostic needs to be reliable, precise, and long lasting. Its design is driven by both the tokamak severe environment and the high performances required for machine protection. The preliminary design phase is ongoing. Paramount issues are being tackled, relative to wide spectral band optical design, material choice, and optomechanical difficulties due to the limited space available for this instrument in the ports, since many other diagnostics and services are also present. Recent progress of the diagnostic optical design and status of associated R and D are presented.

Davi, M.; Corre, Y.; Guilhem, D.; Jullien, F.; Reichle, R.; Salasca, S.; Travere, J. M. [Association Euratom CEA, CEA/DSM/IRFM, Cadarache, 13108 Saint-Paul-lez-Durance (France); Cal, E. de la; Manzanares, A.; Pablos, J. L. de [Association Euratom CIEMAT, Av. Complutense 22, 28040 Madrid (Spain); Migozzi, J. B. [JBM Optique, 11 Av. de la division Leclerc, 92310 Sevres (France)

2008-10-15T23:59:59.000Z

499

DOE Challenge Home Case Study, Clifton View Homes, Coupeville, WA, Systems Home  

Energy.gov (U.S. Department of Energy (DOE)) Indexed Site

Clifton View Clifton View Homes Coupeville, WA BUILDING TECHNOLOGIES OFFICE DOE Challenge Home builders are in the top 1% of builders in the country meeting the extraordinary levels of excellence and quality specifi ed by the U.S. Department of Energy. Every DOE Challenge Home starts with ENERGY STAR for Homes Version 3 for an energy-effi cient home built on a solid foundation of building science research. Then, even more advanced technologies are designed in for a home that goes above and beyond current code to give you the superior quality construction, HVAC, appliances, indoor air quality, safety, durability, comfort, and solar-ready components along with ultra-low or no utility bills. This provides homeowners with a quality home that will last for generations to come.

500

Regulation of Gene Expression by Synthetic DNA-Binding Ligands  

E-Print Network (OSTI)

Regulation of Gene Expression by Synthetic DNA-Binding Ligands Peter B. Dervan ( ) · Adam T. Poulin

Dervan, Peter B.