National Library of Energy BETA

Sample records for gene transfection view

  1. Nano-biolistics: a method of biolistic transfection of cells and tissues using a gene gun with novel nanometer-sized projectiles

    E-Print Network [OSTI]

    O'Brien, John A; Lummis, Sarah C R

    2011-06-10

    -biolistics: a method of biolistic transfection of cells and tissues using a gene gun with novel nanometer-sized projectiles John A O’Brien1 and Sarah CR Lummis1,2* Abstract Background: Biolistic transfection is proving an increasingly popular method... gene gun (Bio- Rad, Hercules, CA) is one of the most widely used. This gene gun, which delivers particles superficially over a relatively wide area, has proved useful for cultured cells or thin tissue sections, and the use of a modified barrel has...

  2. Fibre based cellular transfection

    E-Print Network [OSTI]

    2008-01-01

    and K. Dholakia, "Femtosecond cellular transfection using aFibre based cellular transfection X. Tsampoula 1 *, K.parameters for successful cellular transfection. We readily

  3. Development of nuclear receptor transfected Caco-2 cell lines

    E-Print Network [OSTI]

    Korjamo, Timo

    2006-10-27

    DEVELOPMENT OF NUCLEAR RECEPTOR TRANSFECTED CACO-2 CELL LINES Timo Korjamo University of Kuopio Finland 27th October 2006 ? Background ? Cell lines ? Gene expression ? Functional experiments ? Conclusions Intestinal absorption ? Small intestine... Reinisalo ? Technical assistance: Paula Nyyss?nen, Markku Taskinen ? Collaboration: Professor Pelkonen's group (Univ. Oulu, Finland) ? Funding: Finnish Funding Agency for Technology and Innovation (TEKES) ...

  4. Nanoprobe implantation into mammalian cells by cationic transfection Yan Zhao,a Bryce Sadtler,a Min Lin,b Gregory H. Hockermanb and Alexander Wei*a

    E-Print Network [OSTI]

    Wei, Alexander

    imaging.4 As part of our efforts to design nanoprobes as sensors for intracellular chemical transport, we and near-infrared light, and can serve as substrates for plasmon-enhanced spectroscopies such as surface. Cationic transfection was evaluated on tsA201 cells using three different systems (TransIT®-293, Gene

  5. The effect of swelling and cationic character on gene transfection by pH-sensitive nanocarriers

    E-Print Network [OSTI]

    Auguste, Debra T.

    -Oh You, Debra T. Auguste* School of Engineering and Applied Sciences, Harvard University, 29 Oxford were also compared to vehicles comprised of polyethyleneimine (PEI), dioleoyl tri- ammonium propane]. Dioleoyl trimethyl ammonium propane (DOTAP) [14] and polyethylenimine (PEI) [15] have been used to condense

  6. Ionizing and ultraviolet radiation enhances the efficiency of DNA mediated gene transfer in vitro

    SciTech Connect (OSTI)

    Perez, C.F.

    1984-08-01

    The enhancement effects of ionizing and non-ionizing radiation on the efficiency of DNA mediated gene transfer were studied. Confluent Rat-2 cells were transfected with purified SV40 viral DNA, irradiated with either X-rays or ultraviolet, trypsinized, plated, and assayed for the formation of foci on Rat-2 monolayers. Both ionizing and ultraviolet radiation enhanced the frequency of A-gene transformants/survivor compared to unirradiated transfected cells. These enhancements were non-linear and dose dependent. A recombinant plasmid, pOT-TK5, was constructed that contained the SV40 virus A-gene and the Herpes Simplex virus (HSV) thymidine kinase (TK) gene. Confluent Rat-2 cells transfected with pOT-TK5 DNA and then immediately irradiated with either X-rays or 330 MeV/amu argon particles at the Berkeley Bevalac showed a higher frequency of HAT/sup +/ colonies/survivor than unirradiated transfected cells. Rat-2 cells transfected with the plasmid, pTK2, containing only the HSV TK-gene were enhanced for TK-transformation by both X-rays and ultraviolet radiation. The results demonstrate that radiation enhancement of the efficiency of DNA mediated gene transfer is not explained by increased nuclear uptake of the transfected DNA. Radiation increases the competence of the transfected cell population for genetic transformation. Three models for this increased competence are presented. The targeted integration model, the inducible recombination model, the partition model, and the utilization of DNA mediated gene transfer for DNA repair studies are discussed. 465 references.

  7. Gene silencing in cancer cells using siRNA : genetic and functional studies 

    E-Print Network [OSTI]

    Abdel Rahim, Ma'en Ahmad

    2004-09-30

    Sequence-specific small interfering RNA (siRNA) duplexes can be used for gene silencing in mammalian cells and as mechanistic probes for determining gene function. Transfection of siRNA for specificity protein 1 (Sp1) in MCF-7 or ZR-75 cells...

  8. September 2013 Most Viewed Documents for Renewable Energy Sources...

    Office of Scientific and Technical Information (OSTI)

    September 2013 Most Viewed Documents for Renewable Energy Sources Science Subject Feed Chapter 11. Heat Exchangers Rafferty, Kevin D.; Culver, Gene (1998) 362 > Wet cooling...

  9. April 2013 Most Viewed Documents for Renewable Energy Sources...

    Office of Scientific and Technical Information (OSTI)

    April 2013 Most Viewed Documents for Renewable Energy Sources Science Subject Feed Chapter 11. Heat Exchangers Rafferty, Kevin D.; Culver, Gene (1998) 1252 > Seventh Edition Fuel...

  10. June 2014 Most Viewed Documents for Renewable Energy Sources...

    Office of Scientific and Technical Information (OSTI)

    June 2014 Most Viewed Documents for Renewable Energy Sources Science Subject Feed Chapter 6. Drilling and Well Construction Culver, Gene (1998) 426 > Chapter 11. Heat Exchangers...

  11. Self-assembled pentablock copolymers for selective and sustained gene delivery

    SciTech Connect (OSTI)

    Zhang, Bingqi

    2011-05-15

    The poly(diethylaminoethyl methacrylate) (PDEAEM) - Pluronic F127 - PDEAEM pentablock copolymer (PB) gene delivery vector system has been found to possess an inherent selectivity in transfecting cancer cells over non-cancer cells in vitro, without attaching any targeting ligands. In order to understand the mechanism of this selective transfection, three possible intracellular barriers to transfection were investigated in both cancer and non-cancer cells. We concluded that escape from the endocytic pathway served as the primary intracellular barrier for PB-mediated transfection. Most likely, PB vectors were entrapped and rendered non-functional in acidic lysosomes of non-cancer cells, but survived in less acidic lysosomes of cancer cells. The work highlights the importance of identifying intracellular barriers for different gene delivery systems and provides a new paradigm for designing targeting vectors based on intracellular differences between cell types, rather than through the use of targeting ligands. The PB vector was further developed to simultaneously deliver anticancer drugs and genes, which showed a synergistic effect demonstrated by significantly enhanced gene expression in vitro. Due to the thermosensitive gelation behavior, the PB vector packaging both drug and gene was also investigated for its in vitro sustained release properties by using polyethylene glycol diacrylate as a barrier gel to mimic the tumor matrix in vivo. Overall, this work resulted in the development of a gene delivery vector for sustained and selective gene delivery to tumor cells for cancer therapy.

  12. Isolation and characterization of Agouti: a diabetes/obesity related gene

    DOE Patents [OSTI]

    Woychik, Richard P. (Knoxville, TN)

    1998-01-01

    The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.

  13. Isolation and characterization of Agouti: a diabetes/obesity related gene

    DOE Patents [OSTI]

    Woychik, Richard P. (Knoxville, TN)

    2000-06-27

    The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.

  14. Does evolution in body patterning genes drive

    E-Print Network [OSTI]

    Monteiro, Antónia

    to the adult form of a metazoan has, in particular, led to a relatively common and distinctive view of how the effects one might expect it to have on adult phenotype.(3) Whereas mutations in downstream genes (and low-level Hox genes) might cause subtle shifts in morphology, Hox gene mutations can also cause wholesale

  15. Chapter 12 Gene Genealogies Noah A. Rosenberg

    E-Print Network [OSTI]

    Rosenberg, Noah

    Chapter 12 ­ Gene Genealogies Noah A. Rosenberg Program in Molecular and Computational Biology can be viewed as the result of mutations on a scaffold of genetic relationships ­ a gene genealogy, migration, species divergence, and changes in population size, an understanding of gene genealogies

  16. Recent developments with the human repair genes ERCC2, ERCC4, and XRCC1

    SciTech Connect (OSTI)

    Thompson, L.H.; Caldecott, K.W.; Brookman, K.W.; Weber, C.A.; Salazar, E.S.; Takayama, K.; Fornace, A.J.

    1992-11-06

    ERCC2 was first identified as a gene on human chromosome 19 that complemented the UV sensitivity of CHO UV5 cells in somatic cell hybrids. Subsequent studies localized ERCC2 to the same chromosomal region (19q13.2--13.3) as the ERCC1 gene and showed that the two genes were less than 250 kb apart. Cloning of ERCC2 was accomplished by transfection of genomic DNA into UV5 cells and rescue of the gene from a secondary transformant. Recovery of the gene was aided by the presence of repetitive sequences that were detected on Southern blots with a probe for Alu-family repeats. ERCC2, which is 19 kb in size, quantitatively corrected the UV sensitivity and incision defect in UV5 cells upon transfection. An ERCC2 CDNA clone was recovered from the pcD2 expression library. Although this clone was truncated at the 5 in. end, it conferred transient, but not stable, correction to UV5 cells upon transfection. Based on genomic sequence, this clone was extended by oligonucleotide addition to obtain minigene constructs in which the complete open reading frame (ORF) was present. Translation of the ERCC2 ORF gives an amino acid sequence that has 72% similarity with the S. cerevisiae RAD3 protein, which encodes a DNA helicase.

  17. Overexpression of the human BCL-2 gene product results in growth enhancement of Epstein-Barr virus-immortalized B cells

    SciTech Connect (OSTI)

    Tsujimoto, Yoshihide (Wistar Institute of Anatomy and Biology, Philadelphia, PA (USA))

    1989-03-01

    The biological activity of the human BCL-2 gene product was analyzed in an Epstein-Barr virus (EBV)-infected human lymphoblastoid B-cell line transfected with BCL-2 sequences driven by the simian virus 40 promoter and enhancer. Overproduction of the BCL-2 protein conferred a selective growth advantage to the EBV-infected B cells as compared with control transfectants in low-serum medium and also after seeding at limiting dilution but did not render the cells tumorigenic in athymic nude mice. This growth enhancement was also seen in cells transfected with the BCL-2 gene with its own promoter juxtaposed to the immunoglobulin heavy chain gene enhancer, which represents the translocated form of the BCL-2 gene observed in follicular lymphomas with the t(14;18) translocation. The growth advantage of EBV-infected B cells overproducing the BCL-2 protein is neither due to the enhanced growth factor production nor due to an enhanced sensitivity of the BCL-2 transfectants to interleukins 1 or 6, although both lymphokines are known to stimulate proliferation of EBV-infected B-cell lines. The growth advantage of EBV-infected B-cell lines. The growth advantage of EBV-infected B cells by overproduction of the BCL-2 protein suggests the direct involvement of the BCL-2 gene product in the pathogenesis of follicular lymphoma.

  18. Gene Concepts, Gene Talk, and Gene Patents

    E-Print Network [OSTI]

    Torrance, Andrew W.

    2010-01-01

    Since the existence of a discrete unit of heredity was first proposed by Gregor Mendel, scientific concepts of the “gene” have undergone rapid evolution. Beyond obvious epistemic and operational importance to the scientific community, changing gene...

  19. NEWS & VIEWS Glass dynamics

    E-Print Network [OSTI]

    Weeks, Eric R.

    NEWS & VIEWS Glass dynamics Diverging views on glass transition Gregory B. mc.mckenna@ttu.edu T he glass transition is one of the most intriguing phenomena in the world of soft condensed matter. Despite decades of study, many aspects of the behaviour of glass-forming liquids remain elusive

  20. World Views From fragmentation

    E-Print Network [OSTI]

    World Views From fragmentation to integration Diederik Aerts Leo Apostel Bart De Moor Staf in 1994 by VUB Press: Brussels Internet edition by Clément Vidal and Alexander Riegler #12;World Views 2................................................................................................................... 5 1.1 The fragmentation of our world

  1. Dendritic cells transduced with Rsf-1/HBXAP gene generate specific cytotoxic T lymphocytes against ovarian cancer in vitro

    SciTech Connect (OSTI)

    Sun, Li; Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong ; Kong, Beihua; Sheng, Xiugui; Sheu, Jim Jinn-Chyuan; Shih, Ie-Ming

    2010-04-09

    Recently, some studies have indicated that Rsf-1/HBXAP plays a role in chromatin remodeling and transcriptional regulation that may contribute to tumorigenesis in ovarian cancer. The present study demonstrates that using dendritic cells (DCs) from human cord blood CD34{sup +} cells transduced with Rsf-1/HBXAP DNA plasmids by nucleofection generate specific cytotoxic T lymphocytes (CTL) against ovarian cancer in vitro. After transfection, DCs were analyzed for Rsf-1/HBXAP mRNA expression by RT-PCR and protein expression by Western blot. Then the DC phenotypes, T-cell stimulatory capacity, endocytic activity and migration capacity were explored by flow cytometry analysis, allogeneic mixed lymphocyte reaction, endocytosis and transwell chemotaxis assay, respectively. After transfection, Rsf-1/HBXAP expression was detected at mRNA and protein levels. Allogeneic T-cell proliferation induced by transfected DCs was obviously higher than non-transfected DCs, but the endocytosis capacity and migratory ability were not different. Rsf-1/HBXAP gene-transduced DCs could induce antigen-specific CTL and generate a very potent cytotoxicity to OVCAR3 cells. These data suggest that Rsf-1/HBXAP gene-transduced DCs may be a potential adjuvant immunotherapy for ovarian cancer in clinical applications.

  2. Hydrophobic Modification of Polyethyleneimine Bull. Korean Chem. Soc. 2001, Vol. 22, No. 10 1069 Hydrophobic Modification of Polyethyleneimine for Gene Transfectants

    E-Print Network [OSTI]

    Park, Jong-Sang

    and polycations. Vari- ous kinds of polycationic lipids were prepared by hydro- phobic modification of small derivatives with a small proportion of hydrophobic moiety. As a result of the modification, PEI-Chol and PEI of PEI is molecular weight-dependent and small molecular-weight PEI is reported not to be efficient. We

  3. Comparison of gene expression in pre-implantation bovine embryos either injected or transfected with a siRNA targeted against E-cadherin 

    E-Print Network [OSTI]

    Hanna, Carol Bailey McCormick

    2009-05-15

    The ability to create transgenic livestock is a tremendous benefit in scientific research for many disciplines including functional genomics, pharmaceutical synthesis and development of enhanced production animals. Transgenes ...

  4. NEWS AND VIEWS PERSPECTIVE

    E-Print Network [OSTI]

    Mahler, D. Luke

    NEWS AND VIEWS PERSPECTIVE Niche diversification follows key innovation in Antarctic fish radiation Oxford Street, Cambridge MA 02138, USA Antarctic notothenioid fishes provide a fascinating evolu- tionary diversification has occurred repeatedly and in parallel. Keywords: community ecology, fish, macroevolution, phylo

  5. The Ribosomal DNA Genes Influence Genome-Wide Gene Expression in Drosophila melanogaster 

    E-Print Network [OSTI]

    Paredes Martinez, Lida Silvana

    2012-07-16

    used to address the effect of rDNA deletions on gene expression using reporter genes sensitive to Position Effect Variegation (PEV). In addition, the effect of the deletions in nucleolus size and structure as well as the effect of spontaneous r.... Muller discovered a phenomenon known as Position Effect Variegation (PEV) that changed the view of chromosome structure (48). He created a series of X-ray induced Drosophila mutants that affected the 8 expression of the white+ gene (which confers...

  6. Comparing Genomes with Duplications: A Computational Complexity Point of View

    E-Print Network [OSTI]

    Chauve, Cedric

    Comparing Genomes with Duplications: A Computational Complexity Point of View Guillaume Blin are interested in the computational complexity of computing (dis)similarity measures between two genomes when they contain duplicated genes or genomic markers, a problem that happens frequently when comparing whole

  7. Trichoderma genes

    DOE Patents [OSTI]

    Foreman, Pamela (Los Altos, CA); Goedegebuur, Frits (Vlaardingen, NL); Van Solingen, Pieter (Naaldwijk, NL); Ward, Michael (San Francisco, CA)

    2012-06-19

    Described herein are novel gene sequences isolated from Trichoderma reesei. Two genes encoding proteins comprising a cellulose binding domain, one encoding an arabionfuranosidase and one encoding an acetylxylanesterase are described. The sequences, CIP1 and CIP2, contain a cellulose binding domain. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.

  8. Mining Views: Database Views for Data Mining Hendrik Blockeel #1

    E-Print Network [OSTI]

    Antwerpen, Universiteit

    Mining Views: Database Views for Data Mining Hendrik Blockeel #1 , Toon Calders 2 , Elisa Fromont adriana.prado}@ua.ac.be Abstract-- We present a system towards the integration of data mining mining views. We show that several types of patterns and models over the data, such as itemsets

  9. Mining Views: Database Views for Data Mining Hendrik Blockeel1

    E-Print Network [OSTI]

    Antwerpen, Universiteit

    Mining Views: Database Views for Data Mining Hendrik Blockeel1 , Toon Calders2 , Elisa Fromont1 model towards the inte- gration of data mining into relational database systems, based on the so called virtual mining views. We show that several types of patterns and models over the data, such as itemsets

  10. Protective laser beam viewing device

    DOE Patents [OSTI]

    Neil, George R.; Jordan, Kevin Carl

    2012-12-18

    A protective laser beam viewing system or device including a camera selectively sensitive to laser light wavelengths and a viewing screen receiving images from the laser sensitive camera. According to a preferred embodiment of the invention, the camera is worn on the head of the user or incorporated into a goggle-type viewing display so that it is always aimed at the area of viewing interest to the user and the viewing screen is incorporated into a video display worn as goggles over the eyes of the user.

  11. Mountain View, California: Fiat Res Publica

    E-Print Network [OSTI]

    Tung, Gregory

    1989-01-01

    Mountain View, California: Fiat Res Publica Gregory Tungundifferen­ tiated. In Mountain View, California (populationtoward San Francisco. Mountain View is avoiding a "just say

  12. False color viewing device

    DOE Patents [OSTI]

    Kronberg, J.W.

    1991-05-08

    This invention consists of a viewing device for observing objects in near-infrared false-color comprising a pair of goggles with one or more filters in the apertures, and pads that engage the face for blocking stray light from the sides so that all light reaching, the user`s eyes come through the filters. The filters attenuate most visible light and pass near-infrared (having wavelengths longer than approximately 700 nm) and a small amount of blue-green and blue-violet (having wavelengths in the 500 to 520 nm and shorter than 435 nm, respectively). The goggles are useful for looking at vegetation to identify different species and for determining the health of the vegetation, and to detect some forms of camouflage.

  13. False color viewing device

    DOE Patents [OSTI]

    Kronberg, J.W.

    1992-10-20

    A viewing device for observing objects in near-infrared false-color comprising a pair of goggles with one or more filters in the apertures, and pads that engage the face for blocking stray light from the sides so that all light reaching the user's eyes come through the filters. The filters attenuate most visible light and pass near-infrared (having wavelengths longer than approximately 700 nm) and a small amount of blue-green and blue-violet (having wavelengths in the 500 to 520 nm and shorter than 435 nm, respectively). The goggles are useful for looking at vegetation to identify different species and for determining the health of the vegetation, and to detect some forms of camouflage. 7 figs.

  14. False color viewing device

    DOE Patents [OSTI]

    Kronberg, James W. (108 Independent Blvd., Aiken, SC 29801)

    1992-01-01

    A viewing device for observing objects in near-infrared false-color comprising a pair of goggles with one or more filters in the apertures, and pads that engage the face for blocking stray light from the sides so that all light reaching the user's eyes come through the filters. The filters attenuate most visible light and pass near-infrared (having wavelengths longer than approximately 700 nm) and a small amount of blue-green and blue-violet (having wavelengths in the 500 to 520 nm and shorter than 435 nm, respectively). The goggles are useful for looking at vegetation to identify different species and for determining the health of the vegetation, and to detect some forms of camouflage.

  15. Viewing Conditions and Chromatic Adaptation

    E-Print Network [OSTI]

    Majumder, Aditi

    Linear nonlinear #12;2 Viewing field Self-luminous displays CRT, LCD Reflective media Painting Viewing: Adapting stimulus Subscript E: Equal energy illumination #12;13 Fairchild's model (1991) Inter channel brightness #12;6 11 Definition of Color Appearance Model so much description of color such as: wavelength

  16. Landscape viewing in metropolitan Boston

    E-Print Network [OSTI]

    Teas, Wendy Ann

    1990-01-01

    This thesis recognizes the importance of landscape viewing, especially as a solitary act of contemplation. It suggests the creation of a place from which to gaze upon a vast landscape. It postulates that an observation ...

  17. A Regulator's View of Cogeneration 

    E-Print Network [OSTI]

    Shanaman, S. M.

    1982-01-01

    of the total national electric generation. In view of the energy requirements of Pennsylvania's industry and the impact of increasing energy costs on employment the Commission directed its technical staff to investigate the potential for industrial cogeneration...

  18. Conversation View Outlook Web App User Guide

    E-Print Network [OSTI]

    Calgary, University of

    Conversation View Outlook Web App User Guide Email conversations that include multiple replies and sent messages can be viewed simultaneously using Conversation View. In Exchange 2010 Outlook Web App

  19. Wide field of view telescope

    DOE Patents [OSTI]

    Ackermann, Mark R. (Albuquerque, NM); McGraw, John T. (Placitas, NM); Zimmer, Peter C. (Albuquerque, NM)

    2008-01-15

    A wide field of view telescope having two concave and two convex reflective surfaces, each with an aspheric surface contour, has a flat focal plane array. Each of the primary, secondary, tertiary, and quaternary reflective surfaces are rotationally symmetric about the optical axis. The combination of the reflective surfaces results in a wide field of view in the range of approximately 3.8.degree. to approximately 6.5.degree.. The length of the telescope along the optical axis is approximately equal to or less than the diameter of the largest of the reflective surfaces.

  20. Input a journal Viewing Journals

    E-Print Network [OSTI]

    Sussex, University of

    Journals Contents: Input a journal Viewing Journals Deleting a journal Entering jnl into different period Problems Input a journal 1 Login to Bluqube 2 Select 3 Enter relevant Doc type To select the number of journals you will processing & the total credit value 6 Click on 7 Enter brief description 8

  1. The Catalog View Feature dataset

    E-Print Network [OSTI]

    The Catalog View Feature dataset Hydrography Geometric network HYDRO_NET Polygon feature class defines by FIPS 103, next six digits is a randomly assigned sequential number unique within a CatalogingSeep FCode 485 Water IntakeOutflow Resolution Resolution FCode 48500 Water IntakeOutflow FCode 487 Waterfall

  2. View

    E-Print Network [OSTI]

    2006-02-28

    Feb 28, 2006 ... AMS 2000 Subject Classification: Primary: ... of free NSO solvers, a possible reason is the lack of a significant library of NSO test functions.

  3. Views of the solar system

    SciTech Connect (OSTI)

    Hamilton, C.

    1995-02-01

    Views of the Solar System has been created as an educational tour of the solar system. It contains images and information about the Sun, planets, moons, asteroids and comets found within the solar system. The image processing for many of the images was done by the author. This tour uses hypertext to allow space travel by simply clicking on a desired planet. This causes information and images about the planet to appear on screen. While on a planet page, hyperlinks travel to pages about the moons and other relevant available resources. Unusual terms are linked to and defined in the Glossary page. Statistical information of the planets and satellites can be browsed through lists sorted by name, radius and distance. History of Space Exploration contains information about rocket history, early astronauts, space missions, spacecraft and detailed chronology tables of space exploration. The Table of Contents page has links to all of the various pages within Views Of the Solar System.

  4. Views of wireless network systems.

    SciTech Connect (OSTI)

    Young, William Frederick; Duggan, David Patrick

    2003-10-01

    Wireless networking is becoming a common element of industrial, corporate, and home networks. Commercial wireless network systems have become reliable, while the cost of these solutions has become more affordable than equivalent wired network solutions. The security risks of wireless systems are higher than wired and have not been studied in depth. This report starts to bring together information on wireless architectures and their connection to wired networks. We detail information contained on the many different views of a wireless network system. The method of using multiple views of a system to assist in the determination of vulnerabilities comes from the Information Design Assurance Red Team (IDART{trademark}) Methodology of system analysis developed at Sandia National Laboratories.

  5. For current viewing resistor loads

    DOE Patents [OSTI]

    Lyons, Gregory R. (Tijeras, NM); Hass, Jay B. (Lee's Summit, MO)

    2011-04-19

    The invention comprises a terminal unit for a flat cable comprising a BNC-PCB connector having a pin for electrically contacting one or more conducting elements of a flat cable, and a current viewing resistor having an opening through which the pin extends and having a resistor face that abuts a connector face of the BNC-PCB connector, wherein the device is a terminal unit for the flat cable.

  6. Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A

    SciTech Connect (OSTI)

    Van Hoof, C.; Cayla, X.; Merlevede, W.; Goris, J. [Katholieke Universiteit Leuven, Parish (France)] [and others] [Katholieke Universiteit Leuven, Parish (France); and others

    1995-07-20

    The PTPA gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. PTPA, cloned from human genomic libraries, is encoded by one single-copy gene, composed of 10 exons and 9 introns with a total length of about 60 kb. The transcription start site was determined, and the 5{prime} flanking sequence was analyzed for its potential as a promotor. This region lacks a TATA sequence in the appropriate position relative to the transcription start, is very GC-rich, and contains upstream of the transcription start four Sp1 sites, a feature common to many TATA-less promotors. Based on the homology with DNA binding consensus sequences of transcription factors, we identified in this promotor region several putative DNA binding sites for transcription factors, such as NF-{kappa}B, Myb, Ets-1, Myc, and ATF. Transfection experiments with a construct containing the PTPA promotor region inserted 5{prime} of a luciferase reporter gene revealed that the 5{prime} flanking sequence of the PTPA gene indeed displayed promotor activity that seems to be cell-line dependent. By fluorescence in situ hybridization and G-banding, the PTPA gene was localized to the 9q34 region. The PTPA gene is positioned centromeric of c-abl in a region embracing several genes implicated in oncogenesis. 28 refs., 8 figs., 1 tab.

  7. The Equal Weight View, Agreement, and Commutativity 

    E-Print Network [OSTI]

    Buckler, Rose

    2011-11-23

    This paper investigates Elga’s (2007) Equal Weight View (EWV) and its consequences when understood as a view requiring epistemic peers to ‘split the difference’ following disagreement. The traditional disagreement debate ...

  8. View from the Bridge | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    View from the Bridge View from the Bridge This presentation gives an overview of Caterpillar's R&D focus on advanced diesel engines and exhaust aftertreatment. deer08utley.pdf...

  9. California's Energy Future - The View to 2050

    E-Print Network [OSTI]

    2011-01-01

    Summit on America’s Energy Future (2008), http://www.natural gas. California’s Energy Future - The View to 2050supply California’ s Energy Future - The View to 2050 and

  10. TotalView Training 2015

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home RoomPreservationBio-Inspired Solar FuelTechnologyTel:FebruaryEIA's Today8Topo II: AnUsersTotalView

  11. ISSN 2167-5163 View Publications

    E-Print Network [OSTI]

    Waldschmidt, Michel

    ISSN 2167-5163 View Publications View Author/Related Publications View Reviews Refine Search Co: 180085 Earliest Indexed Publication: 1970 Total Publications: 176 Total Author/Related Publications: 189 Chen Publications (by number in area) Associative rings and algebras Dynamical systems and ergodic

  12. Better Buildings Network View | March 2015 | Department of Energy

    Energy Savers [EERE]

    Better Buildings Network View | March 2015 Better Buildings Network View | March 2015 The Better Buildings Network View monthly newsletter from the U.S. Department of Energy's...

  13. High Performance Builder Spotlight: Clifton View Homes

    SciTech Connect (OSTI)

    2011-01-01

    Clifton View Homes’s remodel of a 1962 rambler, on Whidbey Island in Washington State, cut energy costs by two-thirds.

  14. Toto the Robot Figure 1. Toto, front view. Figure 2. Toto, rear view.

    E-Print Network [OSTI]

    Indiana University

    Toto the Robot Figure 1. Toto, front view. Figure 2. Toto, rear view. Toto the Robot was created so a robot, helps account for his lack of verbal charm. Second, some younger children may recognize in Toto

  15. MyRED Mobiles Student Views

    E-Print Network [OSTI]

    Farritor, Shane

    tap on Shopping Cart, then select term. Tap on Class Search to find courses to place in your shoppingMyRED Mobiles Student Views Mar 2014 Page 1 Login/Sign-in Enter your MyRED /TrueYou credentials. Tap on any Term bar to view a schedule for the selected term. Home Screen/Main Menu Class Schedule

  16. MyRED Mobile Student Views

    E-Print Network [OSTI]

    Tsymbal, Evgeny Y.

    tap on Shopping Cart, then select term. Tap on Class Search to find courses to place in your shoppingMyRED Mobile Student Views Mar 2014 Page 1 Login/Sign-in Enter your MyRED /TrueYou credentials. Tap on any Term bar to view a schedule for the selected term. Home Screen/Main Menu Class Schedule Screen Tap

  17. The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: Down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin

    SciTech Connect (OSTI)

    Song Jin; Jie Chunfa; Polk, Paula; Shridhar, Ravi; Clair, Timothy; Zhang, Jun; Yin, Lijia; Keppler, Daniel . E-mail: dkeppl@lsuhsc.edu

    2006-02-03

    We recently coined CST6 as a novel candidate tumor suppressor gene for breast cancer. CST6 indeed is expressed in the normal human breast epithelium, but little or not at all in breast carcinomas and breast cancer cell lines. Moreover, ectopic expression of CST6 in human breast cancer cells suppressed cell proliferation, migration, invasion, and orthotopic tumor growth. To obtain insights into the molecular mechanism by which CST6 exhibits its pleiotropic effects on tumor cells, we compared global gene expression profiles in mock- and CST6-transfected human MDA-MB-435S cells. Out of 12,625 transcript species, 61 showed altered expression. These included genes for extracellular matrix components, cytokines, kinases, and phosphatases, as well as several key transcription factors. TaqMan PCR assays were used to confirm the microarray data for 7 out of 11 genes. One down-regulated gene product, secreted autotaxin/lyso-phospholipase D, was of particular interest because its down-regulation by CST6 could explain most of CST6's effect on the breast cancer cells. This study thus provides First evidence that CST6 plays a role in the modulation of genes, particularly, genes that are highly relevant to breast cancer progression.

  18. Groundwater Modeling in ArcView: by integrating ArcView, MODFLOW and

    E-Print Network [OSTI]

    Sengupta, Raja

    Groundwater Modeling in ArcView: by integrating ArcView, MODFLOW and MODPATH Abstract Modeling. This paper addresses groundwater modeling which is one of the many entities in environmental modeling in ArcView 3.2a. The objective was to create an integrated system where a user could do groundwater

  19. Mechanisms of Type I Interferon Induction via the Retinoic Acid Inducible Gene-Like Receptor and DNA-Sensor Pathways

    E-Print Network [OSTI]

    Reichardt, Anna

    2015-01-01

    activation in response to both pIC and BDNA- transfection.could synergize with pIC transfection to activate the type Iand LATS1, with and without pIC. We cotransfected control

  20. Human retinoblastoma gene

    SciTech Connect (OSTI)

    Bookstein, R.; Lee, E.Y.H.P.; Peccei, A.; Lee, W.H. (Dept. of Pathology M-012 and Center for Molecular Genetics, Univ. of California, San Diego, La Jolla, CA (US))

    1989-04-01

    Mutational inactivation of the retinoblastoma (RB) gene is considered a fundamental event in the formation of several types of human cancer. A substantial proportion of RB gene mutations are partial or complete deletions that extend an unknown distance beyond one or both ends of the gene. To provide a framework for measuring the extent of these deletions, the authors have constructed a long-range restriction map of SfiI sites spanning 850 kilobases around the RB gene. This map was applied in a molecular analysis of RB gene deletion in breast cancer cell line MB468. A previous study of this cell line demonstrated deletion of the entire RB gene except for exons 1 and 2. Genomic clones containing the deletion junction were isolated from a library made from MB468 DNA. A probe obtained from the far side of the deletion junction was used to localize and clone the unknown 3' endpoint, demonstrating that the chromosomal mutation in this case was a simple deletion spanning 200 kilobases. Sequence analysis of the deletion junction indicated a conservative deletion with no loss or gain of nucleotides. The deletion endpoints had no sequence homology to each other or to any repetitive sequence family, such as Alu, so the recombination event was illegitimate. Structural analysis of this and other RB gene deletions is important for understanding molecular mechanisms of recessive oncogenesis.

  1. Rank Quantization Mountain View, CA, USA

    E-Print Network [OSTI]

    Singh, Jaswinder Pal

    Rank Quantization Ravi Kumar Google Mountain View, CA, USA ravi.k53@gmail.com Ronny Lempel Yahoo and that copies bear this notice and the full citation on the first page. To copy otherwise, to republish, to post

  2. A Utility View of Energy Conservation 

    E-Print Network [OSTI]

    Grant, S. A.

    1979-01-01

    Energy conservation, as viewed by the utility companies, is of real concern due to the energy situation and recent national energy legislation. The conversion programs of the electric utilities, particularly those in the southwestern part of the U...

  3. California's Energy Future - The View to 2050

    E-Print Network [OSTI]

    2011-01-01

    View to 2050 Laser Fusion Energy a Potential Game Changerworld leader in laser fusion energy—a potential game changera Laser Inertial Fusion Energy (LIFE) power plant would be

  4. TotalView Parallel Debugger at NERSC

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    The performance of the GUI can be greatly improved if used in conjunction with free NX software. The TotalView documentation web page is a good resource for learning more...

  5. JOBAID-VIEWING AN EMPLOYEE MATRIX (SUPERVISOR)

    Broader source: Energy.gov [DOE]

    The purpose of this job aid is to guide supervisor users through the step-by-step process of viewing an employee matrix within SuccessFactors Learning.

  6. Incorporating video into Google Mobile Street View

    E-Print Network [OSTI]

    Wright, Christina (Christina E.)

    2010-01-01

    Mobile Street View is a compelling application but suffers from significant latency problems, especially in limited bandwidth circumstances. Currently, the application uses static images to display street level information. ...

  7. A view-sequential 3D display

    E-Print Network [OSTI]

    Cossairt, Oliver S. (Oliver Strider), 1978-

    2003-01-01

    This thesis outlines the various techniques for creating electronic 3D displays and analyzes their commercial potential. The thesis argues for the use of view-sequential techniques in the design of 3D displays based on ...

  8. A common-view disciplined oscillator

    SciTech Connect (OSTI)

    Lombardi, Michael A.; Dahlen, Aaron P.

    2010-05-15

    This paper describes a common-view disciplined oscillator (CVDO) that locks to a reference time scale through the use of common-view global positioning system (GPS) satellite measurements. The CVDO employs a proportional-integral-derivative controller that obtains near real-time common-view GPS measurements from the internet and provides steering corrections to a local oscillator. A CVDO can be locked to any time scale that makes real-time common-view data available and can serve as a high-accuracy, self-calibrating frequency and time standard. Measurement results are presented where a CVDO is locked to UTC(NIST), the coordinated universal time scale maintained at the National Institute of Standards and Technology in Boulder, Colorado.

  9. Microfluidic gene synthesis

    E-Print Network [OSTI]

    Kong, David Sun, 1979-

    2008-01-01

    The ability to synthesize custom de novo DNA constructs rapidly, accurately, and inexpensively is highly desired by researchers, as synthetic genes and longer DNA constructs are enabling to numerous powerful applications ...

  10. Dact genes in mouse kidney development 

    E-Print Network [OSTI]

    Lee, Wen-Chin

    2009-01-01

    cultures, I hypothesize that Dact1 regulates cell proliferation while Dact2 governs cell migration. Experiments including siRNA transfection, BrdU proliferation assay, generation of stable cell lines expressing Dact2 shRNA and wound assay, are designed...

  11. Characterization of a baculovirus lacking the DBP (DNA-binding protein) gene

    SciTech Connect (OSTI)

    Vanarsdall, Adam L. [Department of Microbiology, Nash Hall Room 220, Oregon State University, Corvallis, OR 97331-3804 (United States); Mikhailov, Victor S. [Department of Microbiology, Nash Hall Room 220, Oregon State University, Corvallis, OR 97331-3804 (United States); N.K. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow 117808 (Russian Federation); Rohrmann, George F. [Department of Microbiology, Nash Hall Room 220, Oregon State University, Corvallis, OR 97331-3804 (United States)]. E-mail: rohrmanng@orst.edu

    2007-08-01

    Autographa californica multiple nucleopolyhedrovirus (AcMNPV) encodes two proteins that possess properties typical of single-stranded DNA-binding proteins (SSBs), late expression factor-3 (LEF-3), and a protein referred to as DNA-binding protein (DBP). Whereas LEF-3 is a multi-functional protein essential for viral DNA replication, transporting helicase into the nucleus, and forms a stable complex with the baculovirus alkaline nuclease, the role for DBP in baculovirus replication remains unclear. Therefore, to better understand the functional role of DBP in viral replication, a DBP knockout virus was generated from an AcMNPV bacmid and analyzed. The results of a growth curve analysis indicated that the dbp knockout construct was unable to produce budded virus indicating that dbp is essential. The lack of DBP does not cause a general shutdown of the expression of viral genes, as was revealed by accumulation of early (LEF-3), late (VP39), and very late (P10) proteins in cells transfected with the dbp knockout construct. To investigate the role of DBP in DNA replication, a real-time PCR-based assay was employed and showed that, although viral DNA synthesis occurred in cells transfected with the dbp knockout, the levels were less than that of the control virus suggesting that DBP is required for normal levels of DNA synthesis or for stability of nascent viral DNA. In addition, analysis of the viral DNA replicated by the dbp knockout by using field inversion gel electrophoresis failed to detect the presence of genome-length DNA. Furthermore, analysis of DBP from infected cells indicated that similar to LEF-3, DBP was tightly bound to viral chromatin. Assessment of the cellular localization of DBP relative to replicated viral DNA by immunoelectron microscopy indicated that, at 24 h post-infection, DBP co-localized with nascent DNA at distinct electron-dense regions within the nucleus. Finally, immunoelectron microscopic analysis of cells transfected with the dbp knockout revealed that DBP is required for the production of normal-appearing nucleocapsids and for the generation of the virogenic stroma.

  12. Dumping Dirty Diesels: The View From the Bridge | Department...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Dumping Dirty Diesels: The View From the Bridge Dumping Dirty Diesels: The View From the Bridge 2005 Diesel Engine Emissions Reduction (DEER) Conference Presentations and Posters...

  13. Measurements using tangentially viewing bolometers on TFTR

    SciTech Connect (OSTI)

    Bush, C.E.; Schivell, J.; Budny, R.; Ellis R.A. III; Goldston, R.J.; McCune, D.; Medley, S.S.; Scott, S.D.; Towner, H.H.; Wieland, R.M.; and others

    1988-08-01

    Co- and counter-viewing bolometers aimed along a common tangency chord are being used to study power losses due to charge exchange (CX) of fast ions in neutral beam injection (NBI) heated TFTR plasmas. For unidirectional injection, tangential bolometers oriented to view CX loss of circulating fast ions detect losses from the thermal target plasma (impurity radiation and CX) plus power due to the fast ion CX loss, whereas bolometers oppositely directed measure only the target plasma contribution. The difference between the two signals is a measure of the fast ion CX loss. Additional information is obtained by comparing the tangential bolometer signals with those of perpendicularly viewing bolometer monitors and arrays. The measurements are compared to results of the TRANSP code analysis.

  14. Fields of View for Environmental Radioactivity

    E-Print Network [OSTI]

    Malins, Alex; Machida, Masahiko; Takemiya, Hiroshi; Saito, Kimiaki

    2015-01-01

    The gamma component of air radiation dose rates is a function of the amount and spread of radioactive nuclides in the environment. These radionuclides can be natural or anthropogenic in origin. The field of view describes the area of radionuclides on, or below, the ground that is responsible for determining the air dose rate, and hence correspondingly the external radiation exposure. This work describes Monte Carlo radiation transport calculations for the field of view under a variety of situations. Presented first are results for natural 40K and thorium and uranium series radionuclides distributed homogeneously within the ground. Results are then described for atmospheric radioactive caesium fallout, such as from the Fukushima Daiichi Nuclear Power Plant accident. Various stages of fallout evolution are considered through the depth distribution of 134Cs and 137Cs in soil. The fields of view for the natural radionuclides and radiocaesium are different. This can affect the responses of radiation monitors to th...

  15. BLUE VIEW VISION INSIGHT! Good news--your vision plan

    E-Print Network [OSTI]

    Mease, Kenneth D.

    WELCOME TO BLUE VIEW VISION INSIGHT! Good news--your vision plan is flexible and easy to use, your discounts, and much more! Blue View VisionSM Insight University of California Student Health Insurance Plan (UC SHIP) 2014/15 Your Blue View Vision Insight network Blue View Vision Insight offers you

  16. BLUE VIEW VISION INSIGHT! Good news--your vision plan

    E-Print Network [OSTI]

    Barrett, Jeffrey A.

    WELCOME TO BLUE VIEW VISION INSIGHT! Good news--your vision plan is flexible and easy to use, your discounts, and much more! Blue View Vision InsightSM University of California Student Health Insurance Plan (UC SHIP) 2012/13 Your Blue View Vision Insight Network Blue View Vision Insight offers you

  17. BLUE VIEW VISION INSIGHT! Good news--your vision plan

    E-Print Network [OSTI]

    California at Santa Cruz, University of

    WELCOME TO BLUE VIEW VISION INSIGHT! Good news--your vision plan is flexible and easy to use, your discounts, and much more! Blue View Vision InsightSM University of California Student Health Insurance Plan (UC SHIP) 2013/14 Your Blue View Vision Insight Network Blue View Vision Insight offers you

  18. Gene prioritization and clustering by multi-view text mining , Leon-Charles Tranchevent1

    E-Print Network [OSTI]

    for Biotechnology Information (NCBI) at the National Library of Medicine (NLM). MEDLINE covers all aspects resource for biomedical text mining applications is the MEDLINE database developed by the National Center of controlled vocabularies and the representation schemes of terms occupy a central role in text mining

  19. METHODOLOGY ARTICLE Open Access Gene prioritization and clustering by multi-view

    E-Print Network [OSTI]

    for Biotechnology Informa- tion (NCBI) at the National Library of Medicine (NLM). MEDLINE covers all aspects resource for biomedical text mining applications is the MEDLINE database devel- oped by the National Center of controlled vocabularies and the representation schemes of terms occupy a cen- tral role in text mining

  20. Spectral Clustering Gene Ontology Terms to Group Genes by Function

    E-Print Network [OSTI]

    Zell, Andreas

    Spectral Clustering Gene Ontology Terms to Group Genes by Function Nora Speer, Christian Spieth­12, 2005. c Springer-Verlag Berlin Heidelberg 2005 #12;2 N. Speer, C. Spieth, and A. Zell part-of is-a GO

  1. Molecular cloning and functional characterization of a mouse gene upregulated by lipopolysaccharide treatment reveals alternative splicing

    SciTech Connect (OSTI)

    Du, Kejun; Chen, Yaoming; Dai, Zongming; Bi, Yuan; Cai, Tongjian [Department of Occupational and Environmental Health, Fourth Military Medical University, Xi'an 710032, Shaanxi Province (China)] [Department of Occupational and Environmental Health, Fourth Military Medical University, Xi'an 710032, Shaanxi Province (China); Hou, Lichao [Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province (China)] [Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province (China); Chai, Yubo; Song, Qinghe; Chen, Sumin [Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi Province (China)] [Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an 710032, Shaanxi Province (China); Luo, Wenjing, E-mail: luowenj@fmmu.edu.cn [Department of Occupational and Environmental Health, Fourth Military Medical University, Xi'an 710032, Shaanxi Province (China)] [Department of Occupational and Environmental Health, Fourth Military Medical University, Xi'an 710032, Shaanxi Province (China); Chen, Jingyuan, E-mail: jy_chen@fmmu.edu.cn [Department of Occupational and Environmental Health, Fourth Military Medical University, Xi'an 710032, Shaanxi Province (China)] [Department of Occupational and Environmental Health, Fourth Military Medical University, Xi'an 710032, Shaanxi Province (China)

    2010-01-01

    Treatment of mouse cells with lipopolysaccharide (LPS) potently initiates an inflammatory response, but the underlying mechanisms are unclear. We therefore sought to characterize cDNA sequences of a new mouse LPS-responsive gene, and to evaluate the effects of MLrg. Full-length cDNAs were obtained from LPS-treated NIH3T3 cells. We report that the MLrg gene produces two alternative splice products (GenBank Accession Nos. (DQ316984) and (DQ320011)), respectively, encoding MLrgW and MLrgS polypeptides. Both proteins contain zinc finger and leucine zipper domains and are thus potential regulators of transcription. Expression of MLrgW and MLrgS were robustly upregulated following LPS treatment, and the proteins were localized predominantly in the nuclear membrane and cytoplasm. In stable transfectants over-expressing MLrgW the proportion of cells in G1 phase was significantly reduced, while in cells over-expressing MLrgS the proportion of cells in G2 was significantly increased; both proteins are thus potential regulators of cell cycle progression. Upregulation of MLrgW and MLrgS may be an important component of the LPS inflammatory pathway and of the host response to infection with GNB.

  2. Corroborating Information from Disagreeing Views Alban Galland

    E-Print Network [OSTI]

    Doyen, Laurent

    variety of information and viewpoints from individual Web sources that have different degree sources, many sources will continue to list outdated information if a person has switched jobsCorroborating Information from Disagreeing Views Alban Galland INRIA Saclay ­ Île-de-France LSV ENS

  3. A VIEW OF MATHEMATICS Alain CONNES

    E-Print Network [OSTI]

    Connes, Alain

    A VIEW OF MATHEMATICS Alain CONNES Mathematics is the backbone of modern science and a remarkably e#cient source of new concepts and tools to understand the ``reality'' in which we participate. It plays a basic role in the great new theories of physics of the XXth century such as general relativity, and quantum

  4. Longer View The Road Less Driven

    E-Print Network [OSTI]

    Handy, Susan L.

    Longer View The Road Less Driven Susan Handy I n September 2005, Hurricane Katrina slammed into New.S. Department of Energy [DOE], 2005a), a level unseen in inflation-adjusted terms even at the peak of the late 1970s energy crisis (DOE, 2005b). Shortages in the gasoline supply occurred temporarily in many parts

  5. Accelerated Volumetric Reconstruction From Uncalibrated Camera Views

    E-Print Network [OSTI]

    Whelan, Paul F.

    Accelerated Volumetric Reconstruction From Uncalibrated Camera Views Felicia Brisc, M.S. Ph. D-calibration 11 2.1.2 Bundle Adjustment 13 2.2 Volumetric Reconstruction ................................................. 14 2.2.1 Volumetric Intersection ........................................... 15 2.2.2 Voxel Carving

  6. Gene expression heterogeneous

    E-Print Network [OSTI]

    Khaitovich, Philipp

    that phenotypic variation among individuals and among somatic cells increases with age [1­5]. However, no evidence for an age-dependent increase in variation in gene expression has yet been found [6­9]. Using eight published with this article online). We found that the proportion of probe sets showing a positive

  7. Intervention in gene regulatory networks 

    E-Print Network [OSTI]

    Choudhary, Ashish

    2006-10-30

    In recent years Boolean Networks (BN) and Probabilistic Boolean Networks (PBN) have become popular paradigms for modeling gene regulation. A PBN is a collection of BNs in which the gene state vector transitions according to the rules of one...

  8. Having trouble viewing this email? Click here to view online Engineering eNews

    E-Print Network [OSTI]

    Subramanian, Venkat

    of Service Award Nominations Due View More Events Research News Consortium for Clean Coal Utilization News Chancellor Mark S. Wrighton's announcement on the establishment of the Consortium for Clean Coal Utilization

  9. Having trouble viewing this email? Click here to view online Engineering eNews

    E-Print Network [OSTI]

    Subramanian, Venkat

    Washington University Research to Advance Clean Coal Technology The Consortium for Clean Coal Utilization to research clean coal technology, making St. Louis the nation's center for clean coal research. View Photos

  10. A View of the Cardiovascular Device Industry 

    E-Print Network [OSTI]

    Cisneros, Daniel Aaron

    2013-04-26

    -1 A VIEW OF THE CARDIOVASCULAR DEVICE INDUSTRY A Record of Study by DANIEL AARON CISNEROS Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements for the degree of DOCTOR... OF ENGINEERING Approved by: Chair of Committee, James E. Moore Committee Members, John C. Criscione Fred Clubb Richard H. Lester William Altman Andreas Gute Coordinator, College of Engineering, Robin Autenrieth May 2013 Major Subject...

  11. Lake View Geothermal Facility | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIXsource History ViewInformation

  12. Human AZU-1 gene, variants thereof and expressed gene products

    DOE Patents [OSTI]

    Chen, Huei-Mei; Bissell, Mina

    2004-06-22

    A human AZU-1 gene, mutants, variants and fragments thereof. Protein products encoded by the AZU-1 gene and homologs encoded by the variants of AZU-1 gene acting as tumor suppressors or markers of malignancy progression and tumorigenicity reversion. Identification, isolation and characterization of AZU-1 and AZU-2 genes localized to a tumor suppressive locus at chromosome 10q26, highly expressed in nonmalignant and premalignant cells derived from a human breast tumor progression model. A recombinant full length protein sequences encoded by the AZU-1 gene and nucleotide sequences of AZU-1 and AZU-2 genes and variant and fragments thereof. Monoclonal or polyclonal antibodies specific to AZU-1, AZU-2 encoded protein and to AZU-1, or AZU-2 encoded protein homologs.

  13. ALS Technique Gives Novel View of Lithium Battery Dendrite Growth

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    ALS Technique Gives Novel View of Lithium Battery Dendrite Growth ALS Technique Gives Novel View of Lithium Battery Dendrite Growth Print Thursday, 24 April 2014 09:46 Lithium-ion...

  14. A DATABASE INTEGRATION SYSTEM BASED ON GLOBAL VIEW GENERATION

    E-Print Network [OSTI]

    Lawrence, Ramon

    A DATABASE INTEGRATION SYSTEM BASED ON GLOBAL VIEW GENERATION Uchang Park Duksung Women: database, integration, view, heterogeneity. Abstract: Database integration is a common and growing challenge with the proliferation of database systems, data warehouses, data marts, and other OLAP systems

  15. LabVIEW Core 2 Course | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    LabVIEW Core 2 Course The Lab is advertising a LabVIEW Core 2 course coming to Newport News. Date: Next Thursday and Friday (716, 717) from 8 to 5 at the Canon facility location,...

  16. Cellulosic Biofuels: Expert Views on Prospects for Advancement: Supplementary Material

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Cellulosic Biofuels: Expert Views on Prospects for Advancement: Supplementary Material Erin Baker Keywords: Biofuels; Technology R&D; Uncertainty; Environmental policy 2 #12;1 Introduction This paper contains supplementary material for "Cellulosic Biofuels: Expert Views on Prospects for Advancement

  17. Loop Quantum Gravity: An Inside View

    E-Print Network [OSTI]

    Thomas Thiemann

    2006-08-29

    This is a (relatively) non -- technical summary of the status of the quantum dynamics in Loop Quantum Gravity (LQG). We explain in detail the historical evolution of the subject and why the results obtained so far are non -- trivial. The present text can be viewed in part as a response to an article by Nicolai, Peeters and Zamaklar [hep-th/0501114]. We also explain why certain no go conclusions drawn from a mathematically correct calculation in a recent paper by Helling et al [hep-th/0409182] are physically incorrect.

  18. Energy Efficiency in Buildings- the Utilities View 

    E-Print Network [OSTI]

    Konig, U.

    2008-01-01

    Efficiency in Buildings - the Utilities View U. K?nig RWE Energy AG The energy to lead ESL-IC-08-10-27 Proceedings of the Eighth International Conference for Enhanced Building Operations, Berlin, Germany, October 20-22, 2008 RWE Energy... for Enhanced Building Operations, Berlin, Germany, October 20-22, 2008 RWE Energy / Energieeffizienz bei Immobilien / U. K?nig / ICEBO '08 SEITE 3 RWE ? One of the five leading Energy Companies in Europe > Nr 1 producer of electricity in Germany, Nr 3 in UK...

  19. Having trouble viewing this email? Click here to view online Engineering eNews

    E-Print Network [OSTI]

    Subramanian, Venkat

    Service Day Fri, Mar 12 Spring Break View More Events Research News Energy, Environmental & Chemical the National Aeronautics and Space Administration is for research titled "NASA and NAAPS Products for Air features ideas of Computer Science & Engineering faculty "It's increasingly difficult for the public

  20. Having trouble viewing this email? Click here to view online Meet the 2014 Alumni Achievement

    E-Print Network [OSTI]

    Subramanian, Venkat

    . READ MORE Plantbased plastics target of alumna Robertson's research Megan Robertson, PhD, who earned to petroleumbased plastics, or polymers. READ MORE March 915 Spring Break March 20 Alumni Achievement Awards Special Lecture VIEW MORE EVENTS the technology may help surgeons distinguish cancer cells, which glow in blue

  1. Having trouble viewing this email? Click here to view online Engineering eNews

    E-Print Network [OSTI]

    Subramanian, Venkat

    Chancellor Mark S. Wrighton says America has the potential to solve its energy crisis over the next decade this academic year. Read More U.S. energy future hinges on rapid rollout of emerging clean energy technologies Open Golf Tournament View More Events Research News Harvesting green energy Professor Himadri Pakrasi

  2. Having trouble viewing this email? Click here to view online JANUARY 2014

    E-Print Network [OSTI]

    Subramanian, Venkat

    .S.China Clean Energy Research CenterAdvanced Coal Technology Consortium to continue international progress in advanced coal technologies. VIEW MORE NEWS VIDEO: Blake Marggraff, president of WUTE (Washington University they use to their advantage. WUSTL joins U.S.China Clean Energy Research Center WUSTL joined the U

  3. The dynamics of simple gene network motifs subject to extrinsic fluctuations

    E-Print Network [OSTI]

    Roberts, Elijah; Bohrer, Chris; Sharma, Rati; Assaf, Michael

    2015-01-01

    Cellular processes do not follow deterministic rules, even in identical environments genetically identical cells can make random choices leading to different phenotypes. This randomness originates from fluctuations present in the biomolecular interaction networks. Most previous work has been focused on the intrinsic noise (IN) of these networks. Yet, especially for high-copy-number biomolecules, extrinsic or environmental noise (EN) has been experimentally shown to dominate the variation. Here we develop an analytical formalism that allows for calculation of the effect of extrinsic noise on gene expression motifs. We introduce a new method for modeling bounded EN as an auxiliary species in the master equation. The method is fully generic and is not limited to systems with small EN magnitudes. We focus our study on motifs that can be viewed as the building blocks of genetic switches: a non-regulated gene, a self-inhibiting gene, and a self-promoting gene. The role of the EN properties (magnitude, correlation t...

  4. Method of controlling gene expression

    DOE Patents [OSTI]

    Peters, Norman K. (Berkeley, CA); Frost, John W. (Menlo Park, CA); Long, Sharon R. (Palo Alto, CA)

    1991-12-03

    A method of controlling expression of a DNA segment under the control of a nod gene promoter which comprises administering to a host containing a nod gene promoter an amount sufficient to control expression of the DNA segment of a compound of the formula: ##STR1## in which each R is independently H or OH, is described.

  5. Target Fabrication: A View from the Users

    SciTech Connect (OSTI)

    Kyrala, George A.; Balkey, Matthew M.; Barnes, Cris W.; Batha, Steven H.; Christensen, Cindy R.; Cobble, James A.; Fincke, James; Keiter, Paul; Lanier, Nicholas; Paisley, Dennis; Sorem, Michael; Swift, Damian; Workman, Jonathan

    2004-03-15

    Targets are used for a variety of purposes, but ultimately we use them to validate codes that help us predict and understand new phenomena or effects. The sophistication and complexity of High Energy Density Physics (HEDP) and Inertial Confinement Fusion (ICF) targets has increased in to match the advances made in modeling complex phenomena. The targets have changed from simple hohlraums, spherical geometries, and planar foils, to 3-dimensional geometries that require precision in construction, alignment, and metrology. Furthermore, material properties, such as surface morphologies and volume texture, have significant impact on the behavior of the targets and must be measured and controlled. In the following we will discuss how experimental physicists view targets and the influence that target construction has on interpreting the experimental results. We review a representative sampling of targets fabricated at the Los Alamos National Laboratory that are used in different experiments in support of ICF and HEDP.

  6. TARGET FABRICATION: A VIEW FROM THE USERS.

    SciTech Connect (OSTI)

    Kyrala, George A.; Balkey, Matthew M.; Batha, Steven H.; Barnes, Cris W.; Christensen, Cindy; Cobble, James; Fincke, James; Keiter, Paul; Lanier, Nicholas; Paisley, Dennis; Sorem, Michael S.; Swift, Damian; Workman, Jonathan

    2003-07-18

    Targets are used for a variety of purposes, but ultimately we use them to validate codes that help us predict and understand new phenomena or effects. The sophistication and complexity of High Energy Density Physics (HEDP) and Inertial Confinement Fusion (ICF) targets has increased in time to match the advances made in modeling complex phenomena. The targets have changed from simple hohlraums, spherical geometries, and planar foils, to 3-dimensional geometries that require precision in construction, alignment, and metrology. Furthermore, material properties, such as surface morphologies and volume texture, have significant impact on the behavior of the targets and must be measured and controlled. In the following we will discuss how experimental physicists view targets and the influence that target construction has on interpreting the experimental results. We review a representative sampling of targets fabricated at the Los Alamos National Laboratory that are used in different experiments in support of ICF and HEDP.

  7. GenePRIMP: A GENE PRediction IMprovement Pipeline for Prokaryotic genomes

    SciTech Connect (OSTI)

    Pati, Amrita; Ivanova, Natalia N.; Mikhailova, Natalia; Ovchinnikova, Galina; Hooper, Sean D.; Lykidis, Athanasios; Kyrpides, Nikos C.

    2010-04-01

    We present 'gene prediction improvement pipeline' (GenePRIMP; http://geneprimp.jgi-psf.org/), a computational process that performs evidence-based evaluation of gene models in prokaryotic genomes and reports anomalies including inconsistent start sites, missed genes and split genes. We found that manual curation of gene models using the anomaly reports generated by GenePRIMP improved their quality, and demonstrate the applicability of GenePRIMP in improving finishing quality and comparing different genome-sequencing and annotation technologies.

  8. Gene-environment interactions in genetic epidemiology 

    E-Print Network [OSTI]

    Spinka, Christine Marie

    2005-02-17

    Gene-environment interactions are an area of increasing interest in complex hu- man diseases. The first step in any study of the interactions between genes and the environment involves identifying genes which influence ...

  9. Teaching Evaluation Reports Available to Faculty Center and Operational Teaching Evaluations Report Users View Evaluation

    E-Print Network [OSTI]

    Cafarella, Michael J.

    Teaching Evaluation Reports Available to Faculty Center and Operational Teaching Evaluations Report Users View Evaluation Questions View Instructor Report View Instructor Report with Comments View, subjects and catalog numbers for the reports needed. 2008 Fall 1 Yes Yes email ro

  10. January 2013 Most Viewed Documents for Mathematics And Computing...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    January 2013 Most Viewed Documents for Mathematics And Computing Cybersecurity through Real-Time Distributed Control Systems Kisner, Roger A ORNL; Manges, Wayne W ORNL;...

  11. January 2013 Most Viewed Documents for Fission And Nuclear Technologie...

    Office of Scientific and Technical Information (OSTI)

    January 2013 Most Viewed Documents for Fission And Nuclear Technologies Laboratory studies of shearleach processing of zircaloy clad metallic uranium reactor fuel Swanson, J.L.;...

  12. January 2013 Most Viewed Documents for Power Generation And Distributi...

    Office of Scientific and Technical Information (OSTI)

    2013 Most Viewed Documents for Power Generation And Distribution Lessons from Large-Scale Renewable Energy Integration Studies: Preprint Bird, L.; Milligan, M. Small punch creep...

  13. New ALS Technique Gives Nanoscale Views of Complex Systems

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Nanoscale Views of Complex Systems Print Studying and identifying molecules at the mesoscale has always been challenging-even the best microscopes and spectrometers have...

  14. The Better Buildings Neighborhood View -- December 2013 | Department...

    Broader source: Energy.gov (indexed) [DOE]

    & Publications The Better Buildings Neighborhood View -- July 2013 Focus Series: Philadelphia Energyworks: In the City of Brotherly Love, Sharing Know-How Leads to...

  15. Tracing Technologies: Prisoners' Views in the Era of CSI

    E-Print Network [OSTI]

    Cole, SA

    2013-01-01

    Tracing Technologies: Prisoners’ Views in the Era of CSI.Studies, they argue that prisoners have ‘professionalinterview study of Austrian prisoners. The study design was

  16. April 2013 Most Viewed Documents for Biology And Medicine | OSTI...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    April 2013 Most Viewed Documents for Biology And Medicine Science Subject Feed Publications in biomedical and environmental sciences programs, 1981 Moody, J.B. (comp.) (1982) 306...

  17. March 2014 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    4 Most Viewed Documents for Biology And Medicine Science Subject Feed Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A. Moe; Ryan...

  18. September 2015 Most Viewed Documents for Biology And Medicine...

    Office of Scientific and Technical Information (OSTI)

    September 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. Brookhaven National Lab., Upton, NY (United...

  19. Most Viewed Documents for Biology and Medicine: December 2014...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Most Viewed Documents for Biology and Medicine: December 2014 Dose and volume specification for reporting interstitial therapy NONE (1997) 38 Modification to the Monte Carlo...

  20. July 2013 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    July 2013 Most Viewed Documents for Biology And Medicine Science Subject Feed Carbon Dioxide Sequestering Using Microalgal Systems Daniel J. Stepan; Richard E. Shockey; Thomas A....

  1. September 2013 Most Viewed Documents for Biology And Medicine...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    September 2013 Most Viewed Documents for Biology And Medicine Science Subject Feed Drug Retention Times Center for Human Reliability Studies (2007) 29 > Oleoresin Capsicum...

  2. June 2015 Most Viewed Documents for Biology And Medicine | OSTI...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    June 2015 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. Brookhaven National Lab., Upton, NY (United...

  3. BetterBuildings Network View | January 9, 2014

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    View kicks off 2014, meet the 14 freshest faces to join the Residential Network: BC Hydro; California Energy Commission; District of Columbia Sustainable Energy Utility;...

  4. Better Buildings Network View | September 2014 | Department of...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Publications Focus Series: OREGON-On Bill Financing Program: On-Bill Financing Brings Lenders and Homeowners On Board Better Buildings Network View | December 2014 On-Bill...

  5. Nonviral Vectors for Gene Delivery

    E-Print Network [OSTI]

    Baoum, Abdulgader Ahmed

    2011-04-26

    , two nonviral gene delivery systems using either biodegradable poly(D,L-lactide-co-glycolide) (PLG) nanoparticles or cell penetrating peptide (CPP) complexes have been designed and studied using A549 human lung epithelial cells. PLG nanoparticles were...

  6. Fusion genes in breast cancer

    E-Print Network [OSTI]

    Batty, Elizabeth

    2012-02-07

    Fusion genes in breast cancer Elizabeth M. Batty Clare College, University of Cambridge A dissertation submitted to the University of Cambridge in candidature for the degree of Doctor of Philosophy November 2010 ii... is the outcome of work done in collaboration except where specifically indicated in the text. It has not been submitted whole or in part for any other qualification at any other University. iii Summary Fusion genes in breast cancer Elizabeth Batty...

  7. Prairie View A&M University Whole Campus Energy Analysis 

    E-Print Network [OSTI]

    Haberl, J. S.; Claridge, D. E.; Turner, W. D.

    1991-01-01

    Prairie View A&M University started a large scale energy management program in 1987 and 1988. This report presents an analysis of whole-campus energy consumption at the Prairie View A&M Campus where whole-campus indices were developed that normalize...

  8. Materialized View Selection and Maintenance Using Multi-Query Optimization

    E-Print Network [OSTI]

    Ramamritham, Krithi

    Materialized View Selection and Maintenance Using Multi-Query Optimization Hoshi Mistry ¡ Prasan the differentials as above. Our work addresses the problem of optimizing the main- tenance of a set of materialized Materialized views have been found to be very effective at speeding up queries, and are increasingly being

  9. Page 1 of 10 World View, Metaphysics, and Epistemology

    E-Print Network [OSTI]

    Cobern, William W.

    concept. The recent discussion in science education about world view is essentially a discussion about Working Paper No. 106 William W. Cobern, Ph.D. Associate Professor of Science Education Arizona State from which the concept is taken. #12;Page 1 of 10 Abstract WORLD VIEW, METAPHYSICS, AND EPISTEMOLOGY

  10. O'Leary outlines policy views at confirmation hearing

    SciTech Connect (OSTI)

    Simpson, J.

    1993-02-15

    In her confirmation hearing, Secretary O'Leary outlined her views on various controversial issues. Among these were management of Yucca Mountain and the search for a nuclear waste repository, research on alternative fuels, encouragement of the use of renewable energy sources, and her views on intergrated resource planning.

  11. NEWS AND VIEWS Alternative splicing variability: exactly how similar

    E-Print Network [OSTI]

    Ares Jr., Manny

    NEWS AND VIEWS Alternative splicing variability: exactly how similar are two identical cells and provide the first direct view of alternative splicing at the single cell level. Early hints that alternative splicing might vary within an isogenic cell population came from studies using clever dual

  12. MAGNETIC RESONANCE IMAGE VIEWING ``SCREEN REAL ESTATE'' PROBLEM

    E-Print Network [OSTI]

    Atkins, M. Stella

    MAGNETIC RESONANCE IMAGE VIEWING AND THE ``SCREEN REAL ESTATE'' PROBLEM By Johanna van der Heyden B Degree: Master of Science Title of thesis: Magnetic Resonance Image Viewing and the ``Screen Real Estate. These ``screen real estate'' issues are extensively explored in the literature but not consistently applied

  13. View-Dependent Articulated-Body Simulation with Adaptive Forward

    E-Print Network [OSTI]

    View-Dependent Articulated-Body Simulation with Adaptive Forward Dynamics Daseong Han KAIST (Korea Advanced Institute of Science and Technology) #12;2 Outline Introduction Related Work Simulation Levels and Conquer Algorithm(DCA) For Forward Dynamics Adaptive Forward Dynamics(AFD) View-dependent Forward

  14. PAINTING LIGHTING AND VIEWING EFFECTS Cindy Grimm, Michael Kowalski

    E-Print Network [OSTI]

    Grimm, Cindy

    PAINTING LIGHTING AND VIEWING EFFECTS Cindy Grimm, Michael Kowalski Washington University in St-photorealistic rendering Abstract: We present a system for painting how the appearance of an object changes under different lighting and viewing conditions. The user paints what the object should look like under different lighting

  15. Characterization of a unique embedded gene 

    E-Print Network [OSTI]

    Zhang, Ning

    1999-01-01

    The lysis gene region of bacteriophage [] consists of a cluster of three gene: S, R, and Rz. While the S and R genes are essential for [] lysis under all conditions, the Rz gene is required for [] lysis only under certain conditions. Transposon...

  16. July 2013 Most Viewed Documents for Renewable Energy Sources...

    Office of Scientific and Technical Information (OSTI)

    Heat Exchangers Rafferty, Kevin D.; Culver, Gene (1998) 484 > Environmental Impacts of Wind Power Development on the Population Biology of Greater Prairie-Chickens Sandercock,...

  17. Metazoan Gene Families from Metazome

    DOE Data Explorer [Office of Scientific and Technical Information (OSTI)]

    Metazome is a joint project of the Department of Energy's Joint Genome Institute and the Center for Integrative Genomics to facilitate comparative genomic studies amongst metazoans. Clusters of orthologous and paralogous genes that represent the modern descendents of ancestral gene sets are constructed at key phylogenetic nodes. These clusters allow easy access to clade specific orthology/paralogy relationships as well as clade specific genes and gene expansions. As of version 2.0.4, Metazome provides access to twenty-four sequenced and annotated metazoan genomes, clustered at nine evolutionarily significant nodes. Where possible, each gene has been annotated with PFAM, KOG, KEGG, and PANTHER assignments, and publicly available annotations from RefSeq, UniProt, Ensembl, and JGI are hyper-linked and searchable. The included organisms (by common name) are: Human, Mouse, Rat, Dog, Opossum, Chicken, Frog, Stickleback, Medaka, Fugu pufferfish; Zebrafish, Seasquirt - savignyi, Seasquirt - intestinalis, Amphioxus, Sea Urchin, Fruitfly, Mosquite, Yellow Fever Mosquito, Silkworm, Red Flour Beetle, Worm, Briggsae Worm, Owl limpet (snail), and Sea anemone. [Copied from Metazome Overview at http://www.metazome.net/Metazome_info.php

  18. Gene encoding plant asparagine synthetase

    DOE Patents [OSTI]

    Coruzzi, Gloria M. (New York, NY); Tsai, Fong-Ying (New York, NY)

    1993-10-26

    The identification and cloning of the gene(s) for plant asparagine synthetase (AS), an important enzyme involved in the formation of asparagine, a major nitrogen transport compound of higher plants is described. Expression vectors constructed with the AS coding sequence may be utilized to produce plant AS; to engineer herbicide resistant plants, salt/drought tolerant plants or pathogen resistant plants; as a dominant selectable marker; or to select for novel herbicides or compounds useful as agents that synchronize plant cells in culture. The promoter for plant AS, which directs high levels of gene expression and is induced in an organ specific manner and by darkness, is also described. The AS promoter may be used to direct the expression of heterologous coding sequences in appropriate hosts.

  19. A luciferase reporter gene assay and aryl hydrocarbon receptor 1 genotype predict the LD{sub 50} of polychlorinated biphenyls in avian species

    SciTech Connect (OSTI)

    Manning, Gillian E., E-mail: gmann017@uottawa.ca [Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, Canada K1N 6N5 (Canada); Environment Canada, National Wildlife Research Centre, Ottawa, ON, Canada K1A 0H3 (Canada); Farmahin, Reza, E-mail: mfarm070@uottawa.ca [Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, Canada K1N 6N5 (Canada) [Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, Canada K1N 6N5 (Canada); Environment Canada, National Wildlife Research Centre, Ottawa, ON, Canada K1A 0H3 (Canada); Crump, Doug, E-mail: doug.crump@ec.gc.ca [Environment Canada, National Wildlife Research Centre, Ottawa, ON, Canada K1A 0H3 (Canada)] [Environment Canada, National Wildlife Research Centre, Ottawa, ON, Canada K1A 0H3 (Canada); Jones, Stephanie P., E-mail: stephanie.jones@ec.gc.ca [Environment Canada, National Wildlife Research Centre, Ottawa, ON, Canada K1A 0H3 (Canada); Klein, Jeff, E-mail: jeffery@well-labs.com [Wellington Laboratories Inc., Research Division, Guelph, ON, Canada N1G 3M5 (Canada)] [Wellington Laboratories Inc., Research Division, Guelph, ON, Canada N1G 3M5 (Canada); Konstantinov, Alex, E-mail: alex@well-labs.com [Wellington Laboratories Inc., Research Division, Guelph, ON, Canada N1G 3M5 (Canada)] [Wellington Laboratories Inc., Research Division, Guelph, ON, Canada N1G 3M5 (Canada); Potter, Dave, E-mail: dpotter@well-labs.com [Wellington Laboratories Inc., Research Division, Guelph, ON, Canada N1G 3M5 (Canada)] [Wellington Laboratories Inc., Research Division, Guelph, ON, Canada N1G 3M5 (Canada); Kennedy, Sean W., E-mail: sean.kennedy@ec.gc.ca [Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, Canada K1N 6N5 (Canada); Environment Canada, National Wildlife Research Centre, Ottawa, ON, Canada K1A 0H3 (Canada)

    2012-09-15

    Birds differ in sensitivity to the embryotoxic effects of polychlorinated biphenyls (PCBs), which complicates environmental risk assessments for these chemicals. Recent research has shown that the identities of amino acid residues 324 and 380 in the avian aryl hydrocarbon receptor 1 (AHR1) ligand binding domain (LBD) are primarily responsible for differences in avian species sensitivity to selected dibenzo-p-dioxins and furans. A luciferase reporter gene (LRG) assay was developed in our laboratory to measure AHR1-mediated induction of a cytochrome P450 1A5 reporter gene in COS-7 cells transfected with different avian AHR1 constructs. In the present study, the LRG assay was used to measure the concentration-dependent effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and PCBs 126, 77, 105 and 118 on luciferase activity in COS-7 cells transfected with AHR1 constructs representative of 86 avian species in order to predict their sensitivity to PCB-induced embryolethality and the relative potency of PCBs in these species. The results of the LRG assay indicate that the identity of amino acid residues 324 and 380 in the AHR1 LBD are the major determinants of avian species sensitivity to PCBs. The relative potency of PCBs did not differ greatly among AHR1 constructs. Luciferase activity was significantly correlated with embryolethality data obtained from the literature (R{sup 2} ? 0.87, p < 0.0001). Thus, the LRG assay in combination with the knowledge of a species' AHR1 LBD sequence can be used to predict PCB-induced embryolethality in potentially any avian species of interest without the use of lethal methods on a large number of individuals. -- Highlights: ? PCB embryolethality in birds can be predicted from a species' AHR1 genotype. ? The reporter gene assay is useful for predicting species sensitivity to PCBs. ? The relative potency of PCBs does not appear to differ between AHR1 genotypes. ? Contamination of PCB 105 and PCB 118 did not affect their relative potency values.

  20. Essential Genes Are More Evolutionarily Conserved Than Are Nonessential Genes

    E-Print Network [OSTI]

    Jordan, King

    Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA Jordan, Igor B. Rogozin, Yuri I. Wolf, and Eugene V. Koonin1 National Center for Biotechnology functionally dispensable and/or redundant than are nonessential genes. Given the role of pu- rifying selection

  1. A Narrower Spectrum for a Wider View of Matter

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Wider View of Matter July 9, 2014 Bookmark and Share Ultra-high-resolution dispersive optics of the new inelastic x-ray scattering (IXS) spectrometer (top) and IXS spectrum of...

  2. Sensor planning for novel view generation by camera networks

    E-Print Network [OSTI]

    Barabas, James

    2006-01-01

    This document describes a system for generating novel views of an indoor visual scene by gathering successive 2D images from a set of independent networked robotic cameras. Specifically, the robotic cameras work to seek ...

  3. Plan-view Trajectory Estimation with Dense Stereo Background Models

    E-Print Network [OSTI]

    Darrell, T.

    2001-02-01

    In a known environment, objects may be tracked in multiple views using a set of back-ground models. Stereo-based models can be illumination-invariant, but often have undefined values which inevitably lead to foreground ...

  4. RELATIVISTIC ASTROPHYSICS - THE VIEW FROM TEXAS IN BALTIMORE - (REVIEW)

    E-Print Network [OSTI]

    TRIMBLE, V; MARAN, S

    1981-01-01

    The View from Texas in Baltimore (Review) V. L. TRIMBLEand, most recently, Baltimore (De- cember 15-19, 1980).even its sign) ~ TEXAS IN BALTIMORE f ·very sensitive to

  5. Countermeasures to Urban Heat Islands: A Global View

    E-Print Network [OSTI]

    Meier, Alan

    2006-01-01

    Countermeasures to Urban Heat Islands: A Global View Alanurban climate is the phenomenon of the urban heat island.The urban heat island phenomenon was first observed over one

  6. Development of AeroView: an interactive flow diagnostics laboratory 

    E-Print Network [OSTI]

    Galls, Samuel Fernando

    1996-01-01

    This research includes the development of a set of experimental flow-diagnostics techniques for low speed aerodynamics applications and an interactive software for flow field data acquisition and presentation called AeroView. The data collection...

  7. Host nutrition and infectious disease: an ecological view

    E-Print Network [OSTI]

    Smith, Val H.; Jones II, Tyrees P.; Smith, Marilyn S.

    2005-06-01

    Nutrition is typically discussed in terms of maintaining a proper diet and avoiding nutrient deficiency diseases. However, nutrition can also be viewed from an ecological standpoint: mammalian hosts and their pathogens ...

  8. A Transformational View of Cartography W. R. Tobler

    E-Print Network [OSTI]

    Clarke, Keith

    A Transformational View of Cartography W. R. Tobler ABSTRACT. Cartographic transformations aliases are between points, lines, and areas. Substantive transformations occur in map interpolation transformational grammars, as originally devised for linguistics.2, 4 A similar, though less ambitious, attempt

  9. April 2013 Most Viewed Documents for Fission And Nuclear Technologies...

    Office of Scientific and Technical Information (OSTI)

    April 2013 Most Viewed Documents for Fission And Nuclear Technologies Science Subject Feed Behavior of spent nuclear fuel in water pool storage Johnson, A.B. Jr. (null) 298 >...

  10. June 2015 Most Viewed Documents for Fission And Nuclear Technologies...

    Office of Scientific and Technical Information (OSTI)

    June 2015 Most Viewed Documents for Fission And Nuclear Technologies Estimation of gas leak rates through very small orifices and channels. From sealed PuOsub 2 containers under...

  11. March 2015 Most Viewed Documents for Biology And Medicine | OSTI...

    Office of Scientific and Technical Information (OSTI)

    5 Most Viewed Documents for Biology And Medicine Measuring dopamine release in the human brain with PET Volkow, N.D. Brookhaven National Lab., Upton, NY (United States)|State...

  12. June 2014 Most Viewed Documents for Biology And Medicine | OSTI...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    June 2014 Most Viewed Documents for Biology And Medicine Science Subject Feed Modification to the Monte Carlo N-Particle (MCNP) Visual Editor (MCNPVised) to Read in Computer Aided...

  13. GoddardView National Aeronautics and Space Administration

    E-Print Network [OSTI]

    Christian, Eric

    GoddardView National Aeronautics and Space Administration www.nasa.gov Volume 3 Issue 9 July 2007 On Pg 11 National Aeronautics and Space Administration www.nasa.gov Volume 3 Issue 9 July 2007 LRO

  14. GoddardView National Aeronautics and Space Administration

    E-Print Network [OSTI]

    Christian, Eric

    GoddardView National Aeronautics and Space Administration www.nasa.gov Volume 3 Issue 8 June 2007 Commemorative Issue Royal Visit 2007: Her Majesty Queen Elizabeth II May 8, 2007 National Aeronautics and Space

  15. Inhibin beta E is upregulated by drug-induced endoplasmic reticulum stress as a transcriptional target gene of ATF4

    SciTech Connect (OSTI)

    Brüning, Ansgar, E-mail: ansgar.bruening@med.uni-muenchen.de; Matsingou, Christina; Brem, German Johannes; Rahmeh, Martina; Mylonas, Ioannis

    2012-10-15

    Inhibins and activins are gonadal peptide hormones of the transforming growth factor-? super family with important functions in the reproductive system. By contrast, the recently identified inhibin ?E subunit, primarily expressed in liver cells, appears to exert functions unrelated to the reproductive system. Previously shown downregulation of inhibin ?E in hepatoma cells and anti-proliferative effects of ectopic inhibin ?E overexpression indicated growth-regulatory effects of inhibin ?E. We observed a selective re-expression of the inhibin ?E subunit in HepG2 hepatoblastoma cells, MCF7 breast cancer cells, and HeLa cervical cancer cells under endoplasmic reticulum stress conditions induced by tunicamycin, thapsigargin, and nelfinavir. Analysis of XPB1 splicing and ATF4 activation revealed that inhibin ?E re-expression was associated with induction of the endoplasmic reticulum stress reaction by these drugs. Transfection of an ATF4 expression plasmid specifically induced inhibin ?E expression in HeLa cells and indicates inhibin ?E as a hitherto unidentified target gene of ATF4, a key transcription factor of the endoplasmic reticulum stress response. Therefore, the inhibin ?E subunit defines not only a new player but also a possible new marker for drug-induced endoplasmic reticulum stress. -- Highlights: ? Endoplasmic reticulum stress induces inhibin beta E expression. ? Inhibin beta E is regulated by the transcription factor ATF4. ? Inhibin beta E expression can be used as a marker for drug-induced ER stress.

  16. Patching genes to fight disease

    SciTech Connect (OSTI)

    Holzman, D.

    1990-09-03

    The National Institutes of Health has approved the first gene therapy experiments, one of which will try to cure cancer by bolstering the immune system. The applications of such therapy are limited, but the potential aid to people with genetic diseases is great.

  17. Eukaryotic Gene Prediction Kelli Davies

    E-Print Network [OSTI]

    -scale genome sequencing has revolutionized the field of genetics and biology. Sequencing projects require sophisticated computational analysis to manage vast collections of data. Scientists first sequenced a genome, coding genes comprise 95% of the genome.1 Since then, numerous prokaryotic and eukaryotic genomes have

  18. The cAMP Response Element Binding protein (CREB) is activated by Insulin-like Growth Factor-1 (IGF-1) and regulates myostatin gene expression in skeletal myoblast

    SciTech Connect (OSTI)

    Zuloaga, R. [Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago (Chile)] [Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago (Chile); Fuentes, E.N.; Molina, A. [Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago (Chile) [Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago (Chile); Interdisciplinary Center for Aquaculture Research (INCAR), Víctor Lamas 1290, PO Box 160-C, Concepción (Chile); Valdés, J.A., E-mail: jvaldes@unab.cl [Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago (Chile); Interdisciplinary Center for Aquaculture Research (INCAR), Víctor Lamas 1290, PO Box 160-C, Concepción (Chile)

    2013-10-18

    Highlights: •IGF-1 induces the activation of CREB via IGF-1R/PI3K/PLC signaling pathway. •Calcium dependent signaling pathways regulate myostatin gene expression. •IGF-1 regulates myostatin gene expression via CREB transcription in skeletal myoblast. -- Abstract: Myostatin, a member of the Transforming Growth Factor beta (TGF-?) superfamily, plays an important role as a negative regulator of skeletal muscle growth and differentiation. We have previously reported that IGF-1 induces a transient myostatin mRNA expression, through the activation of the Nuclear Factor of Activated T cells (NFAT) in an IP{sub 3}/calcium-dependent manner. Here we examined the activation of CREB transcription factor as downstream targets of IGF-1 during myoblast differentiation and its role as a regulator of myostatin gene expression. In cultured skeletal myoblast, IGF-1 induced the phosphorylation and transcriptional activation of CREB via IGF-1 Receptor/Phosphatidylinositol 3-Kinase (PI3K)/Phospholipase C gamma (PLC ?), signaling pathways. Also, IGF-1 induced calcium-dependent molecules such as Calmodulin Kinase II (CaMK II), Extracellular signal-regulated Kinases (ERK), Protein Kinase C (PKC). Additionally, we examined myostatin mRNA levels and myostatin promoter activity in differentiated myoblasts stimulated with IGF-1. We found a significant increase in mRNA contents of myostatin and its reporter activity after treatment with IGF-1. The expression of myostatin in differentiated myoblast was downregulated by the transfection of siRNA–CREB and by pharmacological inhibitors of the signaling pathways involved in CREB activation. By using pharmacological and genetic approaches together these data demonstrate that IGF-1 regulates the myostatin gene expression via CREB transcription factor during muscle cell differentiation.

  19. Gene Expression in the Stallion Testes 

    E-Print Network [OSTI]

    Laughlin, Andy M.

    2011-08-08

    Understanding the genes that regulate spermatogenesis and steroidogenesis in the testis is critical for enhancement of stallion fertility. Stallion testicular samples were used to identify candidate genes by cDNA microarrays ...

  20. Enhanced polymeric nanoparticles for gene delivery

    E-Print Network [OSTI]

    Green, Jordan Jamieson

    2007-01-01

    The potential of gene therapy to treat disease and improve human health is tremendous. The failure of viral gene therapy clinical trials due to toxicity, immunogenicity, and carcinogenicity has been tragic and strongly ...

  1. Plant nitrogen regulatory P-PII genes

    DOE Patents [OSTI]

    Coruzzi, Gloria M. (New York, NY); Lam, Hon-Ming (Hong Kong, HK); Hsieh, Ming-Hsiun (Woodside, NY)

    2001-01-01

    The present invention generally relates to plant nitrogen regulatory PII gene (hereinafter P-PII gene), a gene involved in regulating plant nitrogen metabolism. The invention provides P-PII nucleotide sequences, expression constructs comprising said nucleotide sequences, and host cells and plants having said constructs and, optionally expressing the P-PII gene from said constructs. The invention also provides substantially pure P-PII proteins. The P-PII nucleotide sequences and constructs of the

  2. Uses of antimicrobial genes from microbial genome

    DOE Patents [OSTI]

    Sorek, Rotem; Rubin, Edward M.

    2013-08-20

    We describe a method for mining microbial genomes to discover antimicrobial genes and proteins having broad spectrum of activity. Also described are antimicrobial genes and their expression products from various microbial genomes that were found using this method. The products of such genes can be used as antimicrobial agents or as tools for molecular biology.

  3. INVESTIGATION Gene Genealogies Within a Fixed Pedigree,

    E-Print Network [OSTI]

    INVESTIGATION Gene Genealogies Within a Fixed Pedigree, and the Robustness of Kingman's Coalescent, not as a random quantity. Gene genealogical models should describe the outcome of the percolation of genetic provide a surprisingly accurate description of gene genealogies on a fixed pedigree. We study

  4. Neural Networks Approaches for Discovering the Learnable Correlation between Gene Function and Gene

    E-Print Network [OSTI]

    Bonner, Anthony

    Neural Networks Approaches for Discovering the Learnable Correlation between Gene Function and Gene novel clustering and Neural Network (NN) approaches for predicting mouse gene functions from gene. Our results show that neural networks can be extremely useful in this area. We present the improved

  5. Integrating Ontological Knowledge and Textual Evidence in Estimating Gene and Gene Product Similarity

    SciTech Connect (OSTI)

    Sanfilippo, Antonio P.; Posse, Christian; Gopalan, Banu; Tratz, Stephen C.; Gregory, Michelle L.

    2006-06-08

    With the rising influence of the Gene On-tology, new approaches have emerged where the similarity between genes or gene products is obtained by comparing Gene Ontology code annotations associ-ated with them. So far, these approaches have solely relied on the knowledge en-coded in the Gene Ontology and the gene annotations associated with the Gene On-tology database. The goal of this paper is to demonstrate that improvements to these approaches can be obtained by integrating textual evidence extracted from relevant biomedical literature.

  6. Method for determining gene knockouts

    DOE Patents [OSTI]

    Maranas, Costa D; Burgard, Anthony R; Pharkya, Priti

    2013-06-04

    A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.

  7. Method for determining gene knockouts

    DOE Patents [OSTI]

    Maranas, Costas D. (Port Matilda, PA); Burgard, Anthony R. (State College, PA); Pharkya, Priti (State College, PA)

    2011-09-27

    A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.

  8. Gene prioritization aims to identify the most promising genes (or proteins) among a larger pool of candidates

    E-Print Network [OSTI]

    initially developed to help to identify the disease-causing potential candidate genes for asthma, and a sub- sequent association study of 91SNPs in these genes found-onset asthma23 . Beyond positional disease gene identification, gene

  9. Apolipoprotein gene involved in lipid metabolism

    DOE Patents [OSTI]

    Rubin, Edward (Berkeley, CA); Pennacchio, Len A. (Sebastopol, CA)

    2007-07-03

    Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.

  10. How can I view submitted materials? | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History View NewTexas: Energy Resources JumpNew Jersey:Hopkinsville,Advanced ResearchHow can I view

  11. Mountain View, Colorado: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History ViewMayo, Maryland: EnergyInformationOliver, Pennsylvania: EnergyPark, Georgia:View, Colorado:

  12. Prairie View Gas Recovery Biomass Facility | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History ViewMayo, Maryland:NPIProtectio1975) |Texas:PottawattamiePowerSatMontana: EnergyView Gas Recovery

  13. Highland View school | Y-12 National Security Complex

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (JournalvivoHigh energyHighland View school Highland View school Aerial

  14. Installing and Using VMWare View Client for Android This document describes how to get up and running with View if your device runs an Android

    E-Print Network [OSTI]

    Neirotti, Juan Pablo

    1 Installing and Using VMWare View Client for Android This document describes how to get up and running with View if your device runs an Android operating system. Instructions may differ slightly from

  15. Application of multidisciplinary analysis to gene expression.

    SciTech Connect (OSTI)

    Wang, Xuefel; Kang, Huining; Fields, Chris; Cowie, Jim R.; Davidson, George S.; Haaland, David Michael; Sibirtsev, Valeriy; Mosquera-Caro, Monica P.; Xu, Yuexian; Martin, Shawn Bryan; Helman, Paul; Andries, Erik; Ar, Kerem; Potter, Jeffrey; Willman, Cheryl L.; Murphy, Maurice H.

    2004-01-01

    Molecular analysis of cancer, at the genomic level, could lead to individualized patient diagnostics and treatments. The developments to follow will signal a significant paradigm shift in the clinical management of human cancer. Despite our initial hopes, however, it seems that simple analysis of microarray data cannot elucidate clinically significant gene functions and mechanisms. Extracting biological information from microarray data requires a complicated path involving multidisciplinary teams of biomedical researchers, computer scientists, mathematicians, statisticians, and computational linguists. The integration of the diverse outputs of each team is the limiting factor in the progress to discover candidate genes and pathways associated with the molecular biology of cancer. Specifically, one must deal with sets of significant genes identified by each method and extract whatever useful information may be found by comparing these different gene lists. Here we present our experience with such comparisons, and share methods developed in the analysis of an infant leukemia cohort studied on Affymetrix HG-U95A arrays. In particular, spatial gene clustering, hyper-dimensional projections, and computational linguistics were used to compare different gene lists. In spatial gene clustering, different gene lists are grouped together and visualized on a three-dimensional expression map, where genes with similar expressions are co-located. In another approach, projections from gene expression space onto a sphere clarify how groups of genes can jointly have more predictive power than groups of individually selected genes. Finally, online literature is automatically rearranged to present information about genes common to multiple groups, or to contrast the differences between the lists. The combination of these methods has improved our understanding of infant leukemia. While the complicated reality of the biology dashed our initial, optimistic hopes for simple answers from microarrays, we have made progress by combining very different analytic approaches.

  16. Sea Oil Field Satellite Monitoring: An Opera3onal View

    E-Print Network [OSTI]

    Kuligowski, Bob

    :on alone contains 54% of the sea's oil reserves and 45% of its gasSea Oil Field Satellite Monitoring: An Opera3onal View Maurizio, Camp Springs, MD 20746 #12;Outline Introduc:on Sea oil fields Synthe:c Aperture

  17. www.advmat.de www.MaterialsViews.com

    E-Print Network [OSTI]

    Hong, Soon Hyung

    by plasma- enhanced chemical vapor deposition. Methane (CH4) was used as the carbon source to synthesize. The strong protein-based adhesives found in marine mussel Mytilus edulis, provide an important insight for the solidification by oxidative chemical crosslinking.[21­24] From a chemical point of view, covalent crosslinking

  18. Analytic Verification at NASA A View from the Trenches

    E-Print Network [OSTI]

    Jipsen, Peter

    Analytic Verification at NASA A View from the Trenches Willem C. Visser July 31, 1999 Autonomous software is considered a major enabling technology for NASA in order to achieve the goal of their slogan Software Engineering 2 (ASE) group at NASA Ames Research Center is developing analytic verification

  19. Formal Methods Technology Transfer: A View from NASA

    E-Print Network [OSTI]

    Caldwell, James

    Formal Methods Technology Transfer: A View from NASA James L. Caldwell Flight Electronics Technology Division NASA Langley Research Center Hampton, Virginia 23681 26 February 1996 Abstract Since 1988 NASA Langley Research Center has supported a formal methods research group. From its inception

  20. A View Based Survey on Web services Registries

    E-Print Network [OSTI]

    Dustdar, Schahram

    A View Based Survey on Web services Registries Schahram Dustdar and Martin Treiber dustdar Information Systems Institute Distributed Systems Group Web services registries are a cornerstone for the emerging service-oriented architecture and constitute a critical resource for Web services. Based on a case

  1. Shape Anchors for Data-Driven Multi-view Reconstruction

    E-Print Network [OSTI]

    Xiao, Jianxiong

    We present a data-driven method for building dense 3D reconstructions using a combination of recognition and multi-view cues. Our approach is based on the idea that there are image patches that are so distinctive that we ...

  2. Efficient Integrity Checking for Databases with Recursive Views

    E-Print Network [OSTI]

    Martinenghi, Davide

    Efficient Integrity Checking for Databases with Recursive Views Davide Martinenghi and Henning Christiansen Roskilde University, Computer Science Dept. P.O.Box 260, DK-4000 Roskilde, Denmark E-mail: {dm,henning-finding problems, such as network routing and travel planning. The introduction of re- cursion (since 1999

  3. NEWS & VIEWS synchrotron or helium-lamp studies. But

    E-Print Network [OSTI]

    Loss, Daniel

    NEWS & VIEWS synchrotron or helium-lamp studies. But the low energy of the laser photons raises, which should be stronger the lower the kinetic energy of the outgoing electron? Further studies is equivalent to a `pole singularity' in the Green's function. Phil Anderson argues that in the strange metal

  4. Abstract View PERCEPTION OF CONSEQUENCES OF ACTIONS: AN FMRI STUDY

    E-Print Network [OSTI]

    Itti, Laurent

    of a consistent perspective. Previous fMRI studies designed to investigate the perception of mechanical causality was found. Results were interpreted as supporting the view that the perception of elementary mechanical causality events is automatically processed by early low-level mechanisms not influenced by top

  5. View Dependent Isosurface Extraction Yarden Livnat Charles Hansen

    E-Print Network [OSTI]

    Livnat, Yarden

    triangles and is accomplished by the graphics hardware. While the latest isosurface extraction methods have isosurface extraction (NOISE) method. Both NOISE and the later optimal isosurface extraction methodView Dependent Isosurface Extraction Yarden Livnat Charles Hansen University of Utah Abstract We

  6. 1 1999 Rational Software Corporation The View from the Front

    E-Print Network [OSTI]

    Demurjian, Steven A.

    1 ©1999 Rational Software Corporation 3/7/99 R UML The View from the Front James Rumbaugh 9 March 1999 Rational Software Corporation #12; 2 ©1999 Rational Software Corporation 3/7/99 R Evolution Start 1/95 UML 1.3 RTF report 4/99 OMG feedback #12; 3 ©1999 Rational Software Corporation 3/7/99 R UML

  7. NEWS & VIEWS nEutRon StaRS

    E-Print Network [OSTI]

    Loss, Daniel

    NEWS & VIEWS nEutRon StaRS a magnetar by another name Fernando Camilo is at the Columbia core, held stable by neutron degeneracy pressure -- with more mass than the Sun within a 10 km radius -- has central densities comparable to those of nuclei. What does the neutron star sky look like, made

  8. Climate Change -A Personal View Few people in the western

    E-Print Network [OSTI]

    P A G E 4 Climate Change - A Personal View Few people in the western world, or indeed further- cal evidence for climate change over past millennia? If you think it is, then you are naturally drawn afield, can now be unaware of the concern expressed in the media about the possi- ble effects of climate

  9. news and views A key issue for hydrogen storage materi-

    E-Print Network [OSTI]

    Palumbi, Stephen

    news and views A key issue for hydrogen storage materi- als is that the hydrogenation and dehydro be possible to discover stable hydrogen hydrates with higher storage Hydrogen Posture Plan www.eere.energy.gov/hydrogenandfuelcells/pdfs/ hydrogen_posture_plan.pdf 7. Kuhs, W

  10. News and Views International hydrogen association for hydrogen energy

    E-Print Network [OSTI]

    Mench, Matthew M.

    News and Views International hydrogen association for hydrogen energy design competition applied State University IAHE Chapter Student Members, USA c Electrochemical Energy Storage and Conversion Association for Hydrogen Energy supplied a team of 12 members to enter the 1st IAHE Hydrogen Design

  11. Lithium Hexamethyldisilazide: A View of Lithium Ion Solvation

    E-Print Network [OSTI]

    Collum, David B.

    Lithium Hexamethyldisilazide: A View of Lithium Ion Solvation through a Glass-Bottom Boat BRETT L and reactivities, we were drawn to lithium hexamethyldisilazide (LiHMDS; (Me3Si)2NLi) by its promi- nence principles of lithium ion coordination chemistry.2 Understanding how solvation influences organolithium

  12. View this email in a web page Annual Open House

    E-Print Network [OSTI]

    View this email in a web page Annual Open House The 2015 Annual CVHS Open House was a great success Kaitlyn Belanger, class of 2018. Drs. Quinn own and operate Town East Galloway Animal Hospital in Mesquite addition to the award, which is sponsored by Merck Animal Health and the AVC, Merck will make a $2

  13. Delayed Afterglow Onset Interpreted as Baryon-Poor Viewing Angle

    E-Print Network [OSTI]

    David Eichler

    2005-03-24

    We have suggested previously that baryons in GRB fireballs infiltrate from the surrounding walls that collimate the fireball. The efficiency $\\epsilon_b$ for generating blast energy can then be angle dependent. Delayed onset of afterglow can be interpreted as being due to a baryon-poor viewing angle.

  14. research news Renewing an old view of chloroplasts

    E-Print Network [OSTI]

    Tobin, Elaine

    that chloroplasts can form tubular connec- tions, and that these are capable of allow- ing proteins to be exchanged support to a different and older view of a dynamic chloroplast, able to exchange macromolecules with other chloroplasts and perhaps other organelles. Tubular connections The work of KShler et al.1 demonstrates

  15. An Inductive Database Prototype Based on Virtual Mining Views

    E-Print Network [OSTI]

    Robardet, Céline

    An Inductive Database Prototype Based on Virtual Mining Views Hendrik Blockeel K.U. Leuven Leuven, Belgium Toon Calders T.U. Eindhoven Eindhoven, The Netherlands Elisa Fromont K.U. Leuven Leuven, Belgium Bart Goethals Universiteit Antwerpen Antwerp, Belgium Adriana Prado Universiteit Antwerpen Antwerp

  16. Grading Instructions in PeopleSoft View Student Grades

    E-Print Network [OSTI]

    Fletcher, Robin

    - QUNIV Enter your Term - Select from the list of valid values that appear after you clicked on the Search => Student Grades Navigation: Records & Enrollment => Student Term Information => Student Grades Enter;View Student Grades - Demo 3/21/2011 13 Navigation: Records & Enrollment => Student Term Information

  17. In all cases, ALOX5AP and its synonyms were highlighted automati-cally in each view. To highlight disease terms in these views, we

    E-Print Network [OSTI]

    Cai, Long

    the results easy to explore. The novo|seek search box interface allows the user to enter a term (or the production of substances that cause inflammation, such as leukotrienes1. When we entered ALOX5AP as a search a simple view (title, journal and author), a snippet view (a simple view and the search term with flanking

  18. Methods for monitoring multiple gene expression

    DOE Patents [OSTI]

    Berka, Randy (Davis, CA); Bachkirova, Elena (Davis, CA); Rey, Michael (Davis, CA)

    2012-05-01

    The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing Trichoderma reesei ESTs or SSH clones, or a combination thereof. The present invention also relates to computer readable media and substrates containing such array features for monitoring expression of a plurality of genes in filamentous fungal cells.

  19. Methods for monitoring multiple gene expression

    DOE Patents [OSTI]

    Berka, Randy; Bachkirova, Elena; Rey, Michael

    2013-10-01

    The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing Trichoderma reesei ESTs or SSH clones, or a combination thereof. The present invention also relates to computer readable media and substrates containing such array features for monitoring expression of a plurality of genes in filamentous fungal cells.

  20. Imaging gene expression in real-time using aptamers

    SciTech Connect (OSTI)

    Shin, Il Chung

    2011-12-13

    Signal transduction pathways are usually activated by external stimuli and are transient. The downstream changes such as transcription of the activated genes are also transient. Real-time detection of promoter activity is useful for understanding changes in gene expression, especially during cell differentiation and in development. A simple and reliable method for viewing gene expression in real time is not yet available. Reporter proteins such as fluorescent proteins and luciferase allow for non-invasive detection of the products of gene expression in living cells. However, current reporter systems do not provide for real-time imaging of promoter activity in living cells. This is because of the long time period after transcription required for fluorescent protein synthesis and maturation. We have developed an RNA reporter system for imaging in real-time to detect changes in promoter activity as they occur. The RNA reporter uses strings of RNA aptamers that constitute IMAGEtags (Intracellular MultiAptamer GEnetic tags), which can be expressed from a promoter of choice. The tobramycin, neomycin and PDC RNA aptamers have been utilized for this system and expressed in yeast from the GAL1 promoter. The IMAGEtag RNA kinetics were quantified by RT-qPCR. In yeast precultured in raffinose containing media the GAL1 promoter responded faster than in yeast precultured in glucose containing media. IMAGEtag RNA has relatively short half-life (5.5 min) in yeast. For imaging, the yeast cells are incubated with their ligands that are labeled with fluorescent dyes. To increase signal to noise, ligands have been separately conjugated with the FRET (Förster resonance energy transfer) pairs, Cy3 and Cy5. With these constructs, the transcribed aptamers can be imaged after activation of the promoter by galactose. FRET was confirmed with three different approaches, which were sensitized emission, acceptor photobleaching and donor lifetime by FLIM (fluorescence lifetime imaging microscopy). Real-time transcription was measured by FLIM-FRET, which was detected by the decrease in donor lifetime resulting from ligand binding to IMAGEtags that were newly synthesized from the activated GAL1 promoter. The FRET signal was specific for transcribed IMAGEtags.

  1. Gene expression abnormalities in the autistic brain

    E-Print Network [OSTI]

    Chow, Maggie Lok Mun

    2011-01-01

    lymphoblastoid cell lines (LCLs) derived from individualsby profiling gene expression in LCLs derived from livingsubjects. LCLs derived from (1) three monozygotic twin pairs

  2. Exploring candidate genes for human brain diseases from a brain-specific gene network

    E-Print Network [OSTI]

    Jiang,Tianzi

    identifying multiple candidate genes for genetic human brain diseases from a brain-specific gene network; Candidate genes Many common human brain diseases, such as schizo- phrenia, Alzheimer's disease, Parkinson's disease, depres- sion, etc., have prominent genetic components [1,2]. Most researchers think that large

  3. West View, Pennsylvania: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page| Open Energy Information Serbia-EnhancingEtGeorgia: Energy ResourcesTurin, New York: Energy ResourcesView,

  4. Satellite-viewed cloud signatures associated with extratropical cyclogenesis 

    E-Print Network [OSTI]

    Lapierre, Robert Lucien

    1973-01-01

    SATELLITE-VIEWED CLOUD SIGNATURES ASSOCIATED WITH EXTRATROPICAL CYCLOGENESIS A Thesis by ROBERT LUCIEN LAPIERRE Submitted to the Graduate College of Texas ASM University in partial fulfillment of the requirement for the degree of MASTER... OF SCIENCE May 1973 Major Subject: Meteorology SATELLITE-VIENED CLOUD SIGNATURES ASSOCIATED WITH EXTRATROPICAL CYCLOGENESIS A Thesis by ROBERT LUCIEN LAPIERRE Appi"o ed as to st~le and content by: n llcgrceo~& (C ai rman of Conmi t te~ YemberI Hay...

  5. The Oblique Basis Method from an Engineering Point of View

    E-Print Network [OSTI]

    V. G. Gueorguiev

    2012-10-16

    The oblique basis method is reviewed from engineering point of view related to vibration and control theory. Examples are used to demonstrate and relate the oblique basis in nuclear physics to the equivalent mathematical problems in vibration theory. The mathematical techniques, such as principal coordinates and root locus, used by vibration and control theory engineers are shown to be relevant to the Richardson - Gaudin pairing-like problems in nuclear physics.

  6. Harbor View, Ohio: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History View New PagesSustainableGlynnMassachusetts: EnergySoftware Inc Jump to:

  7. Grand View Estates, Colorado: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History View New PagesSustainableGlynn County, Georgia: EnergyGorlitzLedge, Michigan:River, Ohio:

  8. Southern View, Illinois: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page| Open Energy Information Serbia-Enhancing CapacityVectren) Jump to: navigation, search Name: SouthernRockiesSolarView,

  9. Lake View, Alabama: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History View NewTexas:Montezuma, Arizona: Energy Resources Jump to: navigation,Utah: Energy

  10. Finding Predictive Gene Groups from Microarray Data

    E-Print Network [OSTI]

    Buehlmann, Peter

    ur Statistik, ETH Zurich, CH-8092 Zurich, Switzerland Abstract Microarray experiments generate large datasets with expression values for thousands of genes, but not more than a few dozens of samples. A challenging task the genes. We present Pelora, an algorithm based on penalized logistic regression analysis, that combines

  11. Finding Predictive Gene Groups from Microarray Data

    E-Print Network [OSTI]

    Buehlmann, Peter

    ¨ur Statistik, ETH Z¨urich, CH-8092 Z¨urich, Switzerland Abstract Microarray experiments generate large datasets with expression values for thousands of genes, but not more than a few dozens of samples. A challenging task the genes. We present Pelora, an algorithm based on penalized logistic regression analysis, that combines

  12. Posttranscriptional gene silencing in nuclei Paul Hoffera

    E-Print Network [OSTI]

    Pikaard, Craig

    (1). RNAi can be divided into two major categories: transcriptional gene silencing (TGS) and posttranscriptional gene silencing (PTGS). Both TGS and PTGS depend on small interfering RNAs (siRNA) or microRNAs (miRNA) that are produced from double-stranded RNA (dsRNA) precursors. TGS occurs in nuclei via DNA methylation and histone

  13. Gene coding for the E1 endoglucanase

    DOE Patents [OSTI]

    Thomas, S.R.; Laymon, R.A.; Himmel, M.E.

    1996-07-16

    The gene encoding Acidothermus cellulolyticus E1 endoglucanase is cloned and expressed in heterologous microorganisms. A new modified E1 endoglucanase enzyme is produced along with variants of the gene and enzyme. The E1 endoglucanase is useful for hydrolyzing cellulose to sugars for simultaneous or later fermentation into alcohol. 6 figs.

  14. HMM-Based Gene Annotation Methods

    SciTech Connect (OSTI)

    Haussler, David; Hughey, Richard; Karplus, Keven

    1999-09-20

    Development of new statistical methods and computational tools to identify genes in human genomic DNA, and to provide clues to their functions by identifying features such as transcription factor binding sites, tissue, specific expression and splicing patterns, and remove homologies at the protein level with genes of known function.

  15. Genes Regulated by Learning in the Hippocampus

    E-Print Network [OSTI]

    Smith, Desmond J.

    Richard M. Leahy,2 and Desmond J. Smith1* 1 Department of Molecular and Medical Pharmacology and Crump hippocampal gene expression in mice undergoing training in the Morris water maze and control mice forced words: DNA microarrays; gene expression; hip- pocampus; mice; Morris water maze The hippocampus

  16. Assignment of Orthologous Genes via Genome Rearrangement

    E-Print Network [OSTI]

    Lonardi, Stefano

    Assignment of Orthologous Genes via Genome Rearrangement Xin Chen, Jie Zheng, Zheng Fu, Peng Nan of genomes is a fundamental and challenging problem in comparative genomics. Existing methods that assign sequence similarity and evolutionary events at a genome level, where orthologous genes are assumed

  17. de Lange Lab Calcium Phosphate Transfection of 293T Cells

    E-Print Network [OSTI]

    de Lange, Titia

    resuspend the cells by pipetting up and down 3-5 times. Transfer to a 1.5-ml Eppendorf tube. Vortex for 3-5 seconds and keep on ice. 4. Add 25 µl 5 M NaCl to each tube and vortex. This step raises the [Na] to 400 m-G sepharose 1. Transfer 3-4 ml of protein A/G beads to a 15-ml conical tube. Quick-spin in a desktop

  18. Biodegradable PAMAM ester for enhanced transfection efficiency with low cytotoxicity

    E-Print Network [OSTI]

    Park, Jong-Sang

    more toxicity than anionic or neutral dendrimers with terminal carboxylates or hydroxyl groups [12­14]. PAMAM­OH dendrimers have the same structure as PAMAM­NH2 dendrimers (PAMAM) except the surface amine groups of PAMAM­NH2 alternate with hydroxyl groups. PAMAM­OH is relatively nontoxic due to the absence

  19. Tissue-specific gene silencing monitored in circulating RNA

    E-Print Network [OSTI]

    Sehgal, Alfica

    Pharmacologic target gene modulation is the primary objective for RNA antagonist strategies and gene therapy. Here we show that mRNAs encoding tissue-specific gene transcripts can be detected in biological fluids and that ...

  20. Refactoring the nitrogen fixation gene cluster from Klebsiella oxytoca

    E-Print Network [OSTI]

    Zhao, Dehua

    Bacterial genes associated with a single trait are often grouped in a contiguous unit of the genome known as a gene cluster. It is difficult to genetically manipulate many gene clusters because of complex, redundant, and ...

  1. Tissue-Specific Gene Delivery via Nanoparticle Coating

    E-Print Network [OSTI]

    Harris, Todd J.

    The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant ...

  2. Research Articles Combining Drug and Gene Similarity Measures

    E-Print Network [OSTI]

    Sharan, Roded

    of drug-drug and gene-gene similarity measures, combined with a logistic regression component to detection problems due to multiple gene and compound names. Additional attempts were based on reverse

  3. Evolving Materialized Views in Data Warehouse Chuan Zhang,* Xin Yao: Jian Yang t

    E-Print Network [OSTI]

    Yao, Xin

    Evolving Materialized Views in Data Warehouse Chuan Zhang,* Xin Yao: Jian Yang t Abstract- A data have some views materialized, and some vir- 'Chuan Zhang and Xin Yao are with the School of Computer

  4. NATURE CLIMATE CHANGE | VOL 1 | JULY 2011 | www.nature.com/natureclimatechange 195 news & views

    E-Print Network [OSTI]

    Hoffman, Andrew J.

    ', with acceptance of the scienti c evidence for global warming tightly tied with liberal views6 . In short, it has inconvenient truth', liberal members of the public are more likely to endorse that view than conservatives

  5. Fast Multi-View Soft Shadowing via Fragment Reprojection Adam Marrs, Benjamin Watson, Christopher Healey

    E-Print Network [OSTI]

    Young, R. Michael

    Fast Multi-View Soft Shadowing via Fragment Reprojection Adam Marrs, Benjamin Watson, Christopher is constantly #12;2 Adam Marrs, Benjamin Watson, & Christopher Healey / Fast Multi-View Soft Shadowing via

  6. Multi-task and Multi-view Learning for Predicting Adverse Drug Reactions

    E-Print Network [OSTI]

    Zhang, Jintao

    2012-12-31

    , we use computational methods such as biological network analysis, multi-task learning, multi-view learning, and inductive multi-view multi-task learning to systematically investigate the modeling of various ADRs, and construct highly accurate models...

  7. California’s Energy Future: The View to 2050 - Summary Report

    E-Print Network [OSTI]

    Yang, Christopher

    2011-01-01

    Summit on America’s Energy Future (2008), http://www.natural gas. California’s Energy Future - The View to 2050supply California’ s Energy Future - The View to 2050 and

  8. Rain, Rain, Don't Go Away Taking a 360-Degree View of Water

    E-Print Network [OSTI]

    Christian, Eric

    Rain, Rain, Don't Go Away Taking a 360-Degree View of Water The Science of Photography National Flood Studies Field Campaign ­ 6 Taking a 360-Degree View of Water ­ 8 From GLOBE Star Student to GLOBE

  9. Uses of antimicrobial genes from microbial genome Sorek, Rotem...

    Office of Scientific and Technical Information (OSTI)

    We describe a method for mining microbial genomes to discover antimicrobial genes and proteins having broad spectrum of activity. Also described are antimicrobial genes and their...

  10. Single, Key Gene Discovery Could Streamline Production of Biofuels...

    Energy Savers [EERE]

    Single, Key Gene Discovery Could Streamline Production of Biofuels Single, Key Gene Discovery Could Streamline Production of Biofuels August 11, 2011 - 3:51pm Addthis WASHINGTON,...

  11. Visualization and Analysis of 3D Gene Expression Data (Technical...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: Visualization and Analysis of 3D Gene Expression Data Citation Details In-Document Search Title: Visualization and Analysis of 3D Gene Expression Data Recent...

  12. The specificity and evolution of gene regulatory elements

    E-Print Network [OSTI]

    Friedman, Robin Carl

    2010-01-01

    The regulation of gene expression underlies the morphological, physiological, and functional differences between human cell types, developmental stages, and healthy and disease states. Gene regulation in eukaryotes is ...

  13. 414 NATURE PHYSICS | VOL 10 | JUNE 2014 | www.nature.com/naturephysics news & views

    E-Print Network [OSTI]

    Loss, Daniel

    in the polarized flux of scattered light6 . This polarized light provided a periscope for viewing the inner regions

  14. Travel, work, and telecommunications: a view of the electronics revolution and its potential impacts

    E-Print Network [OSTI]

    Garrison, William L.; Deakin, Elizabeth

    2006-01-01

    TELECOMMUNICATIONS: A VIEW OF THE ELECTRONICS REVOLUTION ANDtechnologies and other electronics innovations ontelecommunications and other electronics innovations on the

  15. Radiation-induced gene responses

    SciTech Connect (OSTI)

    Woloschak, G.E.; Paunesku, T.; Shearin-Jones, P.; Oryhon, J.

    1996-12-31

    In the process of identifying genes that are differentially regulated in cells exposed to ultraviolet radiation (UV), we identified a transcript that was repressed following the exposure of cells to a combination of UV and salicylate, a known inhibitor of NF-kappaB. Sequencing this band determined that it has identify to lactate dehydrogenase, and Northern blots confirmed the initial expression pattern. Analysis of the sequence of the LDH 5` region established the presence of NF-kappaB, Sp1, and two Ap-2 elements; two partial AP- 1; one partial RE, and two halves of E-UV elements were also found. Electromobility shift assays were then performed for the AP-1, NF- kappaB, and E-UV elements. These experiments revealed that binding to NF-kappaB was induced by UV but repressed with salicylic acid; UV did not affect AP-1 binding, but salicylic acid inhibited it alone or following UV exposure; and E-UV binding was repressed by UV, and salicylic acid had little effect. Since the binding of no single element correlated with the expression pattern of LDH, it is likely that multiple elements govern UV/salicylate-mediated expression.

  16. Dynamics Modelling of Biolistic Gene Guns

    SciTech Connect (OSTI)

    Zhang, M.; Tao, W.; Pianetta, P.A.

    2009-06-04

    The gene transfer process using biolistic gene guns is a highly dynamic process. To achieve good performance, the process needs to be well understood and controlled. Unfortunately, no dynamic model is available in the open literature for analysing and controlling the process. This paper proposes such a model. Relationships of the penetration depth with the helium pressure, the penetration depth with the acceleration distance, and the penetration depth with the micro-carrier radius are presented. Simulations have also been conducted. The results agree well with experimental results in the open literature. The contribution of this paper includes a dynamic model for improving and manipulating performance of the biolistic gene gun.

  17. Characterization of the Bovine Cathelicidin Gene Family 

    E-Print Network [OSTI]

    Flores, Erin Gillenwaters

    2012-10-19

    and Methods Primer Design Based on available sequence data from the Baylor College of Medicine Bovine Genome Project Btau_4.0 genome assembly, primers were designed for as many unique CATHL loci as possible using Primer3 online (http... pseudogene and one duplicated gene in the CATHL region. The currently annotated CATHL genes, the pseudogene, the duplicated gene, and three STS markers (UniSTS277967, UniSTS 268269, and UniSTS255316) were included in the analysis. Primers for CATHLs 1, 2...

  18. Valley View, Ohio: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page| Open Energy Information Serbia-EnhancingEt Al.,Turin, New York:PowerNewPumatyUvaldeVallesEnergyPark, Oklahoma:View,

  19. Ground control failures. A pictorial view of case studies

    SciTech Connect (OSTI)

    Peng, S.S.

    2007-07-01

    The book shows, in pictorial views, many forms and/or stages of types of failures in mines, for instance, cutter, roof falls, and cribs. In each case, the year of occurrence is stated in the beginning so that the environment or technological background under which it occurred are reflected. The narrative than begins with the mining and geological conditions, followed by a description of the ground control problems and recommended solutions and results, if any. The sections cover failure of pillars, roof falls, longwall, roof bolting, multiple-seam mining, floor heave, longwall, flooding and weathering of coal, old workings, and shortwall and thin-seam plow longwall.

  20. Consumer Views on Transportation and Energy (Third Edition)

    SciTech Connect (OSTI)

    Kubik, M.

    2006-01-01

    This report has been assembled to provide the U.S. Department of Energy's (DOE's) Office of Energy Efficiency and Renewable Energy (EERE) with an idea of how the American public views various transportation, energy, and environmental issues. The data presented in this report have been drawn from multiple sources: surveys conducted by the Opinion Research Corporation (ORC) for the National Renewable Energy Laboratory (NREL) that are commissioned and funded by EERE, Gallup polls, news organization polls, surveys conducted by independent groups and academic institutions, and other sources.

  1. BloombergBusiness: Viewed from space: less corn

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 OutreachProductswsicloudwsiclouddenDVA N C E D B L O OLaura|BilayerBiomimetic Dye MoleculesBlakeViewed from space:

  2. Forest View, Illinois: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History View New PagesSustainable Urban Transport JumpFlowood,Pevafersa JVOhio: EnergyInformation 5

  3. Skyline View, Pennsylvania: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page| Open Energy Information Serbia-Enhancing Capacity forSilicium de ProvenceSolar Jump to: navigation, search Name:View,

  4. Lake View, Maine: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History View NewTexas:Montezuma, Arizona: Energy Resources Jump to: navigation,Utah: EnergyMaine: Energy

  5. A View from the Bridge - DOE Perspective | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:Financing ToolInternationalReportOffice | DepartmentVery1, in:QuarterlyA SolarAA View from the

  6. Bay View, Ohio: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION JEnvironmental Jump to:EAandAmminexInformationArkansas: Energy ResourcesPoint,View, Ohio:

  7. City of Mountain View, Missouri (Utility Company) | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION JEnvironmentalBowerbank,CammackFLIRChurchFontanelle, IowaIowaCityWater) JumpLouisianaView, Missouri

  8. Logan View Public Schools Wind Project | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIXsource History ViewInformationWindsCompressedListguided waves fromLocustLoessLogan

  9. A View from the Bridge - DOE Perspective | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i n c i p a l De p u t y A s s iof1 of 8(MayPROCEEDINGS,Broad view of DOE's

  10. G-TEAMS at Mountain View High School Jennifer Hendryx, Mathias Reynolds

    E-Print Network [OSTI]

    Lega, Joceline

    G-TEAMS at Mountain View High School Jennifer Hendryx, Mathias Reynolds Who are we? Jennifer: Math teacher at Mountain View High school; teaches Alg. II, College Ready Math, and SpEd Alg. I. Goals in physics, Jennifer has been able to participate in Mountain View's Ac Dec as the science coach

  11. "New View" of Protein Folding Reconciled with the Old Through Multiple Unfolding Simulations

    E-Print Network [OSTI]

    Lazaridis, Themis

    "New View" of Protein Folding Reconciled with the Old Through Multiple Unfolding Simulations Themis folding with a preferred pathway on a funnel-like average energy surface. A "new view" of protein folding is the primary unfolding event. The results suggest a synthesis of the "new" and the classical view of protein

  12. Distance matters: the impact of gene proximity in bacterial gene regulation

    E-Print Network [OSTI]

    Otto Pulkkinen; Ralf Metzler

    2013-05-13

    Following recent discoveries of colocalization of downstream-regulating genes in living cells, the impact of the spatial distance between such genes on the kinetics of gene product formation is increasingly recognized. We here show from analytical and numerical analysis that the distance between a transcription factor (TF) gene and its target gene drastically affects the speed and reliability of transcriptional regulation in bacterial cells. For an explicit model system we develop a general theory for the interactions between a TF and a transcription unit. The observed variations in regulation efficiency are linked to the magnitude of the variation of the TF concentration peaks as a function of the binding site distance from the signal source. Our results support the role of rapid binding site search for gene colocalization and emphasize the role of local concentration differences.

  13. Parallel gene synthesis in a microfluidic device

    E-Print Network [OSTI]

    Kong, David S.

    The ability to synthesize custom de novo DNA constructs rapidly, accurately and inexpensively is highly desired by researchers, as synthetic genes and longer DNA constructs are enabling to numerous powerful applications ...

  14. Control of gene expression by cell size

    E-Print Network [OSTI]

    Wu, Chia-Yung

    2010-01-01

    Polyploidy, increased copy number of whole chromosome sets in the genome, is a common cellular state in evolution, development and disease. Polyploidy enlarges cell size and alters gene expression, producing novel phenotypes ...

  15. Noise and multistability in gene regulatory networks

    E-Print Network [OSTI]

    Ozbudak, Ertugrul M. (Ertugrul Mustafa), 1976-

    2004-01-01

    Proteins are the functional machinery in living cells. Proteins interact with each other and bind to DNA to form so-called gene regulatory networks and in this way regulate the level, location and timing of expression of ...

  16. Improved Gene Targeting through Cell Cycle Synchronization

    E-Print Network [OSTI]

    Tsakraklides, Vasiliki

    Gene targeting is a challenge in organisms where non-homologous end-joining is the predominant form of recombination. We show that cell division cycle synchronization can be applied to significantly increase the rate of ...

  17. Adhesion gene regulation in mammary cell proliferation

    E-Print Network [OSTI]

    Lau, Eric HonYui

    2011-01-01

    A. , et al. , Nectin: an adhesion molecule involved in OF CALIFORNIA, MERCED Adhesion Gene Regulation in Mammary1 1.2 Role of Adhesion Molecules in Development and

  18. Changes in gene expression following EMF exposure

    SciTech Connect (OSTI)

    Woloschak, G.E.; Paunesku, T.; Chang-Liu, C.M.; Loberg, L.; Gauger, J.; McCormick, D.

    1997-10-01

    Experiments were designed to examine the effects of electromagnetic field (EMF) exposure on specific gene expression, an effect that can be deleterious, beneficial, or neutral, depending on the long-term consequences; however, the proof of a reproducible, quantitative biological effect (such as change in gene expression) will lead to latter experiments aimed at determining the relative contribution of these changes to cellular consequences. Past work by ourselves and by others has shown that measures of gene expression are extremely sensitive indicators of the cellular and biological effects of ionizing radiation, with transcriptional changes being detected by exposure of cells to doses of {gamma}-rays as low as 0.01 cGy that have no pronounced cellular consequences. On the basis of this work, the authors hypothesized that measures of gene expression will be equally sensitive to EMF effects on cells.

  19. Gene expression profiles in irradiated cancer cells

    SciTech Connect (OSTI)

    Minafra, L.; Bravatà, V.; Russo, G.; Ripamonti, M.; Gilardi, M. C.

    2013-07-26

    Knowledge of the molecular and genetic mechanisms underlying cellular response to radiation may provide new avenues to develop innovative predictive tests of radiosensitivity of tumours and normal tissues and to improve individual therapy. Nowadays very few studies describe molecular changes induced by hadrontherapy treatments, therefore this field has to be explored and clarified. High-throughput methodologies, such as DNA microarray, allow us to analyse mRNA expression of thousands of genes simultaneously in order to discover new genes and pathways as targets of response to hadrontherapy. Our aim is to elucidate the molecular networks involved in the sensitivity/resistance of cancer cell lines subjected to hadrontherapy treatments with a genomewide approach by using cDNA microarray technology to identify gene expression profiles and candidate genes responsible of differential cellular responses.

  20. Molecular structure in soil humic substances: The new view

    SciTech Connect (OSTI)

    Sutton, Rebecca; Sposito, Garrison

    2005-04-21

    A critical examination of published data obtained primarily from recent nuclear magnetic resonance spectroscopy, X-ray absorption near-edge structure spectroscopy, electrospray ionization-mass spectrometry, and pyrolysis studies reveals an evolving new view of the molecular structure of soil humic substances. According to the new view, humic substances are collections of diverse, relatively low molecular mass components forming dynamic associations stabilized by hydrophobic interactions and hydrogen bonds. These associations are capable of organizing into micellar structures in suitable aqueous environments. Humic components display contrasting molecular motional behavior and may be spatially segregated on a scale of nanometers. Within this new structural context, these components comprise any molecules intimately associated with a humic substance, such that they cannot be separated effectively by chemical or physical methods. Thus biomolecules strongly bound within humic fractions are by definition humic components, a conclusion that necessarily calls into question key biogeochemical pathways traditionally thought to be required for the formation of humic substances. Further research is needed to elucidate the intermolecular interactions that link humic components into supramolecular associations and to establish the pathways by which these associations emerge from the degradation of organic litter.

  1. Doug Brutlag 2015 Your Genes and Your Health

    E-Print Network [OSTI]

    Brutlag, Doug

    =252 #12;© Doug Brutlag 2015 Variations in -Amylase Gene Tandem Repeat Arrays Sharp, Cheng & Eichler

  2. Clustering of Pathogenic Genes in Human Co-regulatory Network

    E-Print Network [OSTI]

    Poonen, Bjorn

    Multiple Sclerosis ­ Psoriasis · More connections between similarly classified genes than expected #12

  3. Petascale Debugging via Allinea DDT for IBM Blue Gene /P

    E-Print Network [OSTI]

    Kemner, Ken

    Petascale Debugging via Allinea DDT for IBM Blue Gene /P and IBM Blue Gene /Q Ian Lumb petascaling Allinea DDT Petascaling Allinea DDT for IBM Blue Gene /x Getting Started with Allinea DDT #12 for each core ­ No tree to help here: not fast within one I/O node! ­ The bottleneck of IBM Blue Gene /P

  4. Stress-induced changes in gene interactions in human cells

    E-Print Network [OSTI]

    Ives, Zachary G.

    Stress-induced changes in gene interactions in human cells Renuka R. Nayak1 , William E. Bernal2 environments by changing gene expression and gene interactions. To study how human cells response to stress, we endo- plasmic reticulum stress and exposure to ionizing radiation. We identified thousands of genes

  5. Gene for ataxia-telangiectasia complementation group D (ATDC)

    DOE Patents [OSTI]

    Murnane, J.P.; Painter, R.B.; Kapp, L.N.; Yu, L.C.

    1995-03-07

    Disclosed herein is a new gene, an AT gene for complementation group D, the ATDC gene and fragments thereof. Nucleic acid probes for the gene are provided as well as proteins encoded by the gene, cDNA therefrom, preferably a 3 kilobase (kb) cDNA, and recombinant nucleic acid molecules for expression of the proteins. Further disclosed are methods to detect mutations in the gene, preferably methods employing the polymerase chain reaction (PCR). Also disclosed are methods to detect AT genes from other AT complementation groups. 30 figs.

  6. Gene for ataxia-telangiectasia complementation group D (ATDC)

    DOE Patents [OSTI]

    Murnane, John P. (San Francisco, CA); Painter, Robert B. (Burlingame, CA); Kapp, Leon N. (San Rafael, CA); Yu, Loh-Chung (Redwood City, CA)

    1995-03-07

    Disclosed herein is a new gene, an AT gene for complementation group D, the ATDC gene and fragments thereof. Nucleic acid probes for said gene are provided as well as proteins encoded by said gene, cDNA therefrom, preferably a 3 kilobase (kb) cDNA, and recombinant nucleic acid molecules for expression of said proteins. Further disclosed are methods to detect mutations in said gene, preferably methods employing the polymerase chain reaction (PCR). Also disclosed are methods to detect AT genes from other AT complementation groups.

  7. Gene Conversion and DNA Sequence Polymorphism in the Sex-Determination Gene fog-2 and Its Paralog ftr-1

    E-Print Network [OSTI]

    Bergthorsson, Ulfar

    Gene Conversion and DNA Sequence Polymorphism in the Sex-Determination Gene fog-2 and Its Paralog to duplication events. fog-2, a sex-determination gene unique to Caenorhabditis elegans and implicated of unknown function. Synonymous sequence divergence in regions of fog-2 and ftr-1 (excluding recent gene

  8. Instrumentation requirements from the user's view. [For airbreathing hypersonic engines

    SciTech Connect (OSTI)

    Harsha, P.T.

    1988-01-01

    The use of combustor diagnostics is considered from the point of view of demonstration of performance of an airbreathing hypersonic engine. The basic need is seen to be that of providing the data necessary to verify performance predictions for the engine as installed in the airplane. This necessitates the use of a diagnostics capability that can provide the inputs required by the computational analyses that will be used to assess this performance. Because of the cost of ground test facilities, a premium is placed on measurement technique reliability and redundancy of instrumentation. A mix of nonintrusive optical techniques and probe-based measurements is seen to be the best approach using current diagnostics capability; one such instrument mix is outlined for a ramjet/scramjet test program. 11 references.

  9. Scioto: A Framework for Global-ViewTask Parallelism

    SciTech Connect (OSTI)

    Dinan, James S.; Krishnamoorthy, Sriram; Larkins, D. B.; Nieplocha, Jaroslaw; Sadayappan, Ponnuswamy

    2008-09-09

    We introduce Scioto, Shared Collections of Task Objects, a framework for supporting task-parallelism in one-sided and global-view parallel programming models. Scioto provides lightweight, locality aware dynamic load balancing and interoperates with existing parallel models including MPI, SHMEM, CAF, and Global Arrays. Through task parallelism, the Scioto framework provides a solution for overcoming load imbalance and heterogeneity as well as dynamic mapping of computation onto emerging multicore architectures. In this paper, we present the design and implementation of the Scioto framework and demonstrate its effectiveness on the Unbalanced Tree Search (UTS) benchmark and two quantum chemistry codes: the closed shell Self-Consistent Field (SCF) method and a sparse tensor contraction kernel extracted from a coupled cluster computation. We explore the efficiency and scalability of Scioto through these sample applications and demonstrate that is offers low overhead, achieves good performance on heterogeneous and multicore clusters, and scales to hundreds of processors.

  10. Update: Oil protectionism - three views of US vulnerability

    SciTech Connect (OSTI)

    Not Available

    1987-06-30

    World oil prices seem to have stabilized above the US $18 mark, many US publics fear that market power will once again be transferred to the Organization of Petroleum Exporting Countries (OPEC). When the price was weak, many observers said the weakness reflected victory over OPEC, as if the 1986 oil price crash were a result of the Organization's failure to exert its selfish will. Now that prices are higher, will US dependency on OPEC mushroom, fueling a campaign to protect indigenous crude oil prices through effective import fees. In this issue, latest available official import statistics for three views on how US oil import dependency might be evolving are supplied. This issue also contains: (1) ED refining netback data for the US Gulf and West Coasts, Rotterdam, and Singapore for late June 1987; and (2) the ED fuel price/tax series for countries of the Eastern Hemisphere, June 1987 edition. 4 figures, 5 tables.

  11. Measuring semantic similarities by combining gene ontology annotations and gene co-function networks

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Peng, Jiajie; Uygun, Sahra; Kim, Taehyong; Wang, Yadong; Rhee, Seung Y.; Chen, Jin

    2015-02-14

    Background: Gene Ontology (GO) has been used widely to study functional relationships between genes. The current semantic similarity measures rely only on GO annotations and GO structure. This limits the power of GO-based similarity because of the limited proportion of genes that are annotated to GO in most organisms. Results: We introduce a novel approach called NETSIM (network-based similarity measure) that incorporates information from gene co-function networks in addition to using the GO structure and annotations. Using metabolic reaction maps of yeast, Arabidopsis, and human, we demonstrate that NETSIM can improve the accuracy of GO term similarities. We also demonstratemore »that NETSIM works well even for genomes with sparser gene annotation data. We applied NETSIM on large Arabidopsis gene families such as cytochrome P450 monooxygenases to group the members functionally and show that this grouping could facilitate functional characterization of genes in these families. Conclusions: Using NETSIM as an example, we demonstrated that the performance of a semantic similarity measure could be significantly improved after incorporating genome-specific information. NETSIM incorporates both GO annotations and gene co-function network data as a priori knowledge in the model. Therefore, functional similarities of GO terms that are not explicitly encoded in GO but are relevant in a taxon-specific manner become measurable when GO annotations are limited.« less

  12. THE JOURNAL OF GENE MEDICINE RESEARCH ARTICLE J Gene Med 2005; 7: 898907.

    E-Print Network [OSTI]

    Hemminki, Akseli

    , FIN-70211 Kuopio, Finland 2 Cancer Gene Therapy Group, Rational Drug Design Program, Biomedicum, University of Helsinki, FIN-00140 Helsinki, Finland 3 Department of Oncology, Helsinki University Central Hospital, FIN-00290 Helsinki, Finland 4 Gene Therapy Unit, Kuopio University Hospital, Kuopio, Finland

  13. Key gene regulating cell wall biosynthesis and recalcitrance in Populus, gene Y

    DOE Patents [OSTI]

    Chen, Jay; Engle, Nancy; Gunter, Lee E.; Jawdy, Sara; Tschaplinski, Timothy J.; Tuskan, Gerald A.

    2015-12-08

    This disclosure provides methods and transgenic plants for improved production of renewable biofuels and other plant-derived biomaterials by altering the expression and/or activity of Gene Y, an O-acetyltransferase. This disclosure also provides expression vectors containing a nucleic acid (Gene Y) which encodes the polypeptide of SEQ ID NO: 1 and is operably linked to a heterologous promoter.

  14. Single gene and gene interaction effects on fertilization and embryonic survival rates in cattle

    E-Print Network [OSTI]

    Yandell, Brian S.

    Single gene and gene interaction effects on fertilization and embryonic survival rates in cattle H as an entire pathway can be used in selection programs to improve reproduction performance in dairy cattle. Key to genotypes in dairy cattle that are suboptimal for reproductive competence (Royal et al., 2000; Lucy, 2001

  15. Towards an informative mutant phenotype for every bacterial gene

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Deutschbauer, Adam; Price, Morgan N.; Wetmore, Kelly M.; Tarjan, Daniel R.; Xu, Zhuchen; Shao, Wenjen; Leon, Dacia; Arkin, Adam P.; Skerker, Jeffrey M.

    2014-08-11

    Mutant phenotypes provide strong clues to the functions of the underlying genes and could allow annotation of the millions of sequenced yet uncharacterized bacterial genes. However, it is not known how many genes have a phenotype under laboratory conditions, how many phenotypes are biologically interpretable for predicting gene function, and what experimental conditions are optimal to maximize the number of genes with a phenotype. To address these issues, we measured the mutant fitness of 1,586 genes of the ethanol-producing bacterium Zymomonas mobilis ZM4 across 492 diverse experiments and found statistically significant phenotypes for 89% of all assayed genes. Thus, inmore »Z. mobilis, most genes have a functional consequence under laboratory conditions. We demonstrate that 41% of Z. mobilis genes have both a strong phenotype and a similar fitness pattern (cofitness) to another gene, and are therefore good candidates for functional annotation using mutant fitness. Among 502 poorly characterized Z. mobilis genes, we identified a significant cofitness relationship for 174. For 57 of these genes without a specific functional annotation, we found additional evidence to support the biological significance of these gene-gene associations, and in 33 instances, we were able to predict specific physiological or biochemical roles for the poorly characterized genes. Last, we identified a set of 79 diverse mutant fitness experiments in Z. mobilis that are nearly as biologically informative as the entire set of 492 experiments. Therefore, our work provides a blueprint for the functional annotation of diverse bacteria using mutant fitness.« less

  16. Pathogenicity island mobility and gene content.

    SciTech Connect (OSTI)

    Williams, Kelly Porter

    2013-10-01

    Key goals towards national biosecurity include methods for analyzing pathogens, predicting their emergence, and developing countermeasures. These goals are served by studying bacterial genes that promote pathogenicity and the pathogenicity islands that mobilize them. Cyberinfrastructure promoting an island database advances this field and enables deeper bioinformatic analysis that may identify novel pathogenicity genes. New automated methods and rich visualizations were developed for identifying pathogenicity islands, based on the principle that islands occur sporadically among closely related strains. The chromosomally-ordered pan-genome organizes all genes from a clade of strains; gaps in this visualization indicate islands, and decorations of the gene matrix facilitate exploration of island gene functions. A %E2%80%9Clearned phyloblocks%E2%80%9D method was developed for automated island identification, that trains on the phylogenetic patterns of islands identified by other methods. Learned phyloblocks better defined termini of previously identified islands in multidrug-resistant Klebsiella pneumoniae ATCC BAA-2146, and found its only antibiotic resistance island.

  17. Id-1 gene and gene products as therapeutic targets for treatment of breast cancer and other types of carcinoma

    DOE Patents [OSTI]

    Desprez, Pierre-Yves; Campisi, Judith

    2014-08-19

    A method for treatment of breast cancer and other types of cancer. The method comprises targeting and modulating Id-1 gene expression, if any, for the Id-1 gene, or gene products in breast or other epithelial cancers in a patient by delivering products that modulate Id-1 gene expression. When expressed, Id-1 gene is a prognostic indicator that cancer cells are invasive and metastatic.

  18. Universal light-switchable gene promoter system

    DOE Patents [OSTI]

    Quail, Peter H.; Huq, Enamul; Tepperman, James; Sato, Sae

    2005-02-22

    An artificial promoter system that can be fused upstream of any desired gene enabling reversible induction or repression of the expression of the gene at will in any suitable host cell or organisms by light is described. The design of the system is such that a molecule of the plant photoreceptor phytochrome is targeted to the specific DNA binding site in the promoter by a protein domain that is fused to the phytochrome and that specifically recognizes this binding site. This bound phytochrome, upon activation by light, recruits a second fusion protein consisting of a protein that binds to phytochrome only upon light activation and a transcriptional activation domain that activates expression of the gene downstream of the promoter.

  19. Dynamic Pricing with Limited Supply Moshe Babaioff, Microsoft Research Silicon Valley, Mountain View CA, USA

    E-Print Network [OSTI]

    Fiat, Amos

    Dynamic Pricing with Limited Supply Moshe Babaioff, Microsoft Research Silicon Valley, Mountain University, Ithaca NY, USA Aleksandrs Slivkins, Microsoft Research Silicon Valley, Mountain View CA, USA We

  20. Network Performance Improvements For Web Services : : An End-to-End View

    E-Print Network [OSTI]

    Radhakrishnan, Sivasankar

    2014-01-01

    Modern Web Services . . . . . . . . . . . . . . . . . . . .handshake overhead for all web services accessed by ChromeImprovements For Web Services – An End-to-End View A

  1. Report of Energy Efficiency Study and Metering/Utilities Profile for Electricity Deregulation at Prairie View A&M University (PVAMU) Prairie View, Texas 

    E-Print Network [OSTI]

    Zhu, Y.; Claridge, D. E.; Giebler, T.; Abushakra, B.; Turner, W. D.

    1999-01-01

    The physical plant director and staff at Prairie View A&M University (PVAMU) do a good job of maintaining PVAMU facilities and keeping expenses down. During our visit, however, we were able to identify several opportunities ...

  2. Energy spectrum of black holes : a new view

    E-Print Network [OSTI]

    Abhishek Majhi

    2015-12-22

    Energy of a black hole is usually quantized by invoking some area quantization scheme after expressing the energy in terms of the horizon area. However, in this approach one has to quantize the local and asymptotic energy of the black hole separately and the two results do not manifest any physical correspondence with each other. Here, as opposed to this practice, we find the unique energy spectrum of black holes by adopting a top-down approach. The physical links among the underlying quantum theory, statistical mechanics and thermodynamics of the black hole horizon play the central role in determining the energy spectrum. The energy spectrum that we obtain, explicitly reveals the correspondence between asymptotic and local observations through the presence of the surface gravity of the horizon as a parameter in the spectrum, rather than being expressed as a function of area and consequently getting quantized in the usual approach. Thus, our result presents a new view as far as black hole energy quantization is concerned. The calculations are performed using the quantum geometric description of black hole horizons as laid down by loop quantum gravity.

  3. $?$-Ray Pulsars: Emission Zones and Viewing Geometries, A Computer Animation

    E-Print Network [OSTI]

    I. -A. Yadigaroglu; Roger W. Romani

    1994-06-08

    The computer animation illustrates the geometries described in a paper by the same authors. The preprint is available as number 9401045. The opening scene shows dipole field lines emanating from the polar caps of a rotating neutron star. The dipole axis is inclined along the green rods. The field lines shown are defined from the condition that they be tangent to the light cylinder (the cylindrical radius at which the tangential velocity of rotation reaches the speed of light). The static dipole field lines are smoothly morphed into the correct retarted-potential vacuum solutions. A red surface spanning these field lines is painted. In the next scene the blue surfaces represent the outer gaps above the surface of last closed field lines. High energy emission (blue) is produced in these outer gaps, and is beamed tangentially along the field lines. The radio emission (green) originates close to the surface of the star and is beamed along the dipole axes. The inclination angle $\\alpha$ of the dipole and the viewing angle $\\zeta$ are chosen to match the Crab parameters; $\\alpha$ = 70, $\\zeta$ = 65. The corresponding light curve is computed and shown for these angles, and the red dot traces rotation phase. The next scene shows the situation for angles appropriate to PSR1706-44; $\\alpha$ = 45, $\\zeta$ = 65. The final scene is a possibility for Geminga; $\\alpha$ = 20, $\\zeta$ = 75. These angles are poorly constrained as there is no radio emission.

  4. Viewing spin structures with soft x-ray microscopy

    SciTech Connect (OSTI)

    Fischer, Peter

    2010-06-01

    The spin of the electron and its associated magnetic moment marks the basic unit for magnetic properties of matter. Magnetism, in particular ferromagnetism and antiferromagnetism is described by a collective order of these spins, where the interaction between individual spins reflects a competition between exchange, anisotropy and dipolar energy terms. As a result the energetically favored ground state of a ferromagnetic system is a rather complex spin configuration, the magnetic domain structure. Magnetism is one of the eldest scientific phenomena, yet it is one of the most powerful and versatile utilized physical effects in modern technologies, such as in magnetic storage and sensor devices. To achieve highest storage density, the relevant length scales, such as the bit size in disk drives is now approaching the nanoscale and as such further developments have to deal with nanoscience phenomena. Advanced characterization tools are required to fully understand the underlying physical principles. Magnetic microscopes using polarized soft X-rays offer a close-up view into magnetism with unique features, these include elemental sensitivity due to X-ray magnetic dichroism effects as contrast mechanism, high spatial resolution provided by state-of-the-art X-ray optics and fast time resolution limited by the inherent time structure of current X-ray sources, which will be overcome with the introduction of ultrafast and high brilliant X-ray sources.

  5. Synchrotron Radiation Therapy from a Medical Physics point of view

    SciTech Connect (OSTI)

    Prezado, Y.; Berkvens, P.; Braeuer-Krisch, E.; Renier, M.; Bravin, A. [ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz B.P. 220, 38043 Grenoble Cedex (France); Adam, J. F. [INSERM, U836, Equipe 6, BP 170, Grenoble Cedex 9, F-38042 (France); Universite Joseph Fourier, B.P. 51, Grenoble Cedex 9, F-38041 (France); ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz B.P. 220, 38043 Grenoble Cedex (France); Centre Hospitalier Universitaire, B.P. 217, Grenoble Cedex 9, F-38043 (France); Martinez-Rovira, I. [ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz B.P. 220, 38043 Grenoble Cedex (France); Institut de Tecniques Energetiques, Universitat Politecnica de Catalunya, Diagonal 647, E-08028 Barcelona (Spain); Fois, G. [ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz B.P. 220, 38043 Grenoble Cedex (France); Dipartimento di Fisica, Universita degli Studi di Cagliari, Strada Provinciale Monserrato Sestu km 0.700, Monserrato, Cagliari 09042 (Italy); Thengumpallil, S. [ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz B.P. 220, 38043 Grenoble Cedex (France); Dipartimento di Fisica E. Amaldi, Universita degli Studi Roma Tre, 84 Via della Vasca Navale, 00146 Roma (Italy); Edouard, M.; Deman, P. [INSERM, U836, Equipe 6, BP 170, Grenoble Cedex 9, F-38042 (France); Universite Joseph Fourier, B.P. 51, Grenoble Cedex 9, F-38041 (France); ID17 Biomedical Beamline, European Synchrotron Radiation Facility (ESRF), 6 Rue Jules Horowitz B.P. 220, 38043 Grenoble Cedex (France); Vautrin, M. [INSERM, U836, Equipe 6, BP 170, Grenoble Cedex 9, F-38042 (France); Universite Joseph Fourier, B.P. 51, Grenoble Cedex 9, F-38041 (France); DOSIsoft, Cachan (France)

    2010-07-23

    Synchrotron radiation (SR) therapy is a promising alternative to treat brain tumors, whose management is limited due to the high morbidity of the surrounding healthy tissues. Several approaches are being explored by using SR at the European Synchrotron Radiation Facility (ESRF), where three techniques are under development Synchrotron Stereotactic Radiation Therapy (SSRT), Microbeam Radiation Therapy (MRT) and Minibeam Radiation Therapy (MBRT).The sucess of the preclinical studies on SSRT and MRT has paved the way to clinical trials currently in preparation at the ESRF. With this aim, different dosimetric aspects from both theoretical and experimental points of view have been assessed. In particular, the definition of safe irradiation protocols, the beam energy providing the best balance between tumor treatment and healthy tissue sparing in MRT and MBRT, the special dosimetric considerations for small field dosimetry, etc will be described. In addition, for the clinical trials, the definition of appropiate dosimetry protocols for patients according to the well established European Medical Physics recommendations will be discussed. Finally, the state of the art of the MBRT technical developments at the ESRF will be presented. In 2006 A. Dilmanian and collaborators proposed the use of thicker microbeams (0.36-0.68 mm). This new type of radiotherapy is the most recently implemented technique at the ESRF and it has been called MBRT. The main advantage of MBRT with respect to MRT is that it does not require high dose rates. Therefore it can be more easily applied and extended outside synchrotron sources in the future.

  6. Current trends in mapping human genes

    SciTech Connect (OSTI)

    Mckusick, V.A. )

    1991-01-01

    The human is estimated to have at least 50,000 expressed genes (gene loci). Some information is available concerning about 5,000 of these gene loci and about 1,900 have been mapped, i.e., assigned to specific chromosomes (and in most instances particular chromosome regions). Progress has been achieved by a combination of physical mapping (e.g., study of somatic cell hybrids and chromosomal in situ hybridization) and genetic mapping (e.g., genetic linkage studies). New methods for both physical and genetic mapping are expanding the armamentarium. The usefulness of the mapping information is already evident; the spin-off from the Human Genome Project (HGP) begins immediately. the complete nucleotide sequence is the ultimate map of the human genome. Sequencing, although already under way for limited segments of the genome, will await further progress in gene mapping, and in particular creation of contig maps for each chromosome. Meanwhile the technology of sequencing and sequence information handling will be developed.

  7. Differential gene expression Anja von Heydebreck

    E-Print Network [OSTI]

    Spang, Rainer

    on ANOVA/linear models r continuous response variable: linear models; censored survival times: e.g. Cox proportional hazards models #12;Example Golub data, 27 ALL vs. 11 AML samples, 3,051 genes. Histogram). The FDR (Benjamini & Hochberg 1995) is the expected proportion of Type I errors among the rejected

  8. Designing Neural Networks Using Gene Expression Programming

    E-Print Network [OSTI]

    Fernandez, Thomas

    1 Designing Neural Networks Using Gene Expression Programming CândidaFerreira Gepsoft, 73 Elmtree aspects of neural networks, such as the weights, the thresholds, and the network architec- ture. Indeed neural network, including the architecture, the weights and thresholds, could be totally encoded

  9. Gene encoding acetyl-coenzyme A carboxylase

    DOE Patents [OSTI]

    Roessler, P.G.; Ohlrogge, J.B.

    1996-09-24

    A DNA encoding an acetyl-coenzyme A carboxylase (ACCase) from a photosynthetic organism and functional derivatives are disclosed which are resistant to inhibition from certain herbicides. This gene can be placed in organisms to increase their fatty acid content or to render them resistant to certain herbicides. 5 figs.

  10. SHORT REVIEW Ecological genomics: understanding gene and

    E-Print Network [OSTI]

    Herman, Mike

    SHORT REVIEW Ecological genomics: understanding gene and genome function in the natural environment MC Ungerer, LC Johnson and MA Herman Division of Biology, Ecological Genomics Institute, Kansas State University, Manhattan, KS, USA The field of ecological genomics seeks to understand the genetic mechanisms

  11. ISSUE 55 JULY 2008 Genes and disease

    E-Print Network [OSTI]

    Rambaut, Andrew

    ISSUE 55 JULY 2008 FUNDING Genes and disease In this issue... FUNDING AND UPDATES 2­5 Project building, in Kenya, South Africa, Uganda and elsewhere in Africa (see page 5). The largest ever study. The Institute will devote a large part of its high-throughput genotyping pipeline, headed by Dr Panos Deloukas

  12. Mechanisms of radiation-induced gene responses

    SciTech Connect (OSTI)

    Woloschak, G.E.; Paunesku, T.

    1996-10-01

    In the process of identifying genes differentially expressed in cells exposed ultraviolet radiation, we have identified a transcript having a 26-bp region that is highly conserved in a variety of species including Bacillus circulans, yeast, pumpkin, Drosophila, mouse, and man. When the 5` region (flanking region or UTR) of a gene, the sequence is predominantly in +/+ orientation with respect to the coding DNA strand; while in the coding region and the 3` region (UTR), the sequence is most frequently in the +/-orientation with respect to the coding DNA strand. In two genes, the element is split into two parts; however, in most cases, it is found only once but with a minimum of 11 consecutive nucleotides precisely depicting the original sequence. The element is found in a large number of different genes with diverse functions (from human ras p21 to B. circulans chitonase). Gel shift assays demonstrated the presence of a protein in HeLa cell extracts that binds to the sense and antisense single-stranded consensus oligomers, as well as to the double- stranded oligonucleotide. When double-stranded oligomer was used, the size shift demonstrated as additional protein-oligomer complex larger than the one bound to either sense or antisense single-stranded consensus oligomers alone. It is speculated either that this element binds to protein(s) important in maintaining DNA is a single-stranded orientation for transcription or, alternatively that this element is important in the transcription-coupled DNA repair process.

  13. What phylogeny and gene genealogy analyses reveal about homoplasy in citrus microsatellite alleles

    E-Print Network [OSTI]

    Barkley, Noelle A.; Krueger, Robert R.; Federici, Claire T.; Roose, Mikeal L.

    2009-01-01

    What phylogeny and gene genealogy analyses reveal aboutAdditionally, gene genealogies (networks) were constructedtaxa. Networks/gene genealogies TCS version 1.13 (Clement et

  14. Gene-supplemented collagen scaffolds for non-viral gene delivery for brain tissue engineering

    E-Print Network [OSTI]

    Bolliet, Catherine

    2007-01-01

    Recent advances in tissue engineering, combining an extracellular matrix (ECM)-like vehicle with therapeutic molecules, cells and/or genes has yielded promising results for brain injury repair. The purpose of this thesis ...

  15. Gene Expression Analyses and Association Studies of Wood Development Genes in Loblolly Pine (Pinus taeda L.) 

    E-Print Network [OSTI]

    Palle, Sreenath Reddy

    2011-10-21

    Gene expression analyses using native populations can provide information on the genetic and molecular mechanisms that determine intraspecific variation and contribute to the understanding of plant development and adaptation ...

  16. Characterization of genes in the sterigmatocystin gene cluster and their role in fitness of Aspergillus nidulans 

    E-Print Network [OSTI]

    Sim, Sung Chur

    2001-01-01

    Sterigmatocystin (ST) is the penulitmate precursor of aflatoxin (AF) and a carcinogenic mycotoxin produced by A. nidulans, a fungus well established as a genetic model system. Previously, a 60 kb ST gene cluster in A. ...

  17. THE JOURNAL OF GENE MEDICINE RESEARCH ARTICLE J Gene Med 2011; 13: 253261.

    E-Print Network [OSTI]

    Hemminki, Akseli

    , Helsinki, Finland 2HUSLAB, Helsinki University Central Hospital, Helsinki, Finland 3Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland 4International Comprehensive Cancer Center Docrates, Helsinki, Finland Correspondence to: Akseli Hemminki, Cancer Gene Therapy

  18. Evidence of efficient stop codon readthrough in four mammalian genes

    E-Print Network [OSTI]

    Loughran, Gary

    Stop codon readthrough is used extensively by viruses to expand their gene expression. Until recent discoveries in Drosophila, only a very limited number of readthrough cases in chromosomal genes had been reported. Analysis ...

  19. Diametric gene-dosage effects as windows into neurogenetic architecture

    E-Print Network [OSTI]

    Crespi, Bernard J.

    Diametric gene-dosage effects as windows into neurogenetic architecture Bernard Crespi Gene, which provide unique insights into neurodevelopmental architecture. These convergent studies of perturbations. One-to-one dosage-phenotype mappings also reveal neurodevelop- mental architecture: what

  20. Rhizobium common nod genes are required for biofilm formation.

    E-Print Network [OSTI]

    Fujishige, Nancy A; Lum, Michelle R; De Hoff, Peter L; Whitelegge, Julian P; Faull, Kym F; Hirsch, Ann M

    2008-01-01

    E. , and Bisseling, T. (2005) Nod factor signaling genes andLegume symbioses: absence of nod genes in photosyntheticactivity of Rhizobium sp. NGR234 Nod-factors on Macroptilium

  1. Rhizobium common nod genes are required for biofilm formation

    E-Print Network [OSTI]

    Fujishige, Nancy A; Lum, Michelle R; De Hoff, Peter L; Whitelegge, Julian P; Faull, Kym F; Hirsch, Ann M

    2008-01-01

    E. , and Bisseling, T. (2005) Nod factor signaling genes andLegume symbioses: absence of nod genes in photosyntheticactivity of Rhizobium sp. NGR234 Nod-factors on Macroptilium

  2. PI Control of Gene Expression in Tumorous Cell Lines 

    E-Print Network [OSTI]

    Mendonca, Rouella J.

    2010-01-16

    Recent experiments are bringing to the fore more and more information about the effects of different treatments on the gene expression of different genes. The results obtained from these experiments show that some definite trends are observed...

  3. Copy Number and Gene Expression: Stochastic Modeling and Therapeutic Application 

    E-Print Network [OSTI]

    Hsu, Fang-Han

    2013-05-01

    (CNAs), which are known to be common mutations in genetic diseases, on steady- state gene expression values, time-course expression activities, and the e?ectiveness of targeted therapy. Assuming DNA copies operate as independent subsystems producing gene...

  4. Text Mining in Cancer Gene and Pathway Prioritization

    E-Print Network [OSTI]

    Riedlinger, Gregory

    Prioritization of cancer implicated genes has received growing attention as an effective way to reduce wet lab cost by computational analysis that ranks candidate genes according to the likelihood that experimental ...

  5. Visualization and Analysis of 3D Gene Expression Data (Technical...

    Office of Scientific and Technical Information (OSTI)

    Technical Report: Visualization and Analysis of 3D Gene Expression Data Citation Details In-Document Search Title: Visualization and Analysis of 3D Gene Expression Data You are...

  6. Environmental Scientists Find Antibiotics, Bacteria, Resistance Genes in Feedlot Dust

    E-Print Network [OSTI]

    Rock, Chris

    Environmental Scientists Find Antibiotics, Bacteria, Resistance Genes in Feedlot Dust :: Texas Tech Today http://today.ttu.edu/2015/01/environmental-scientists-find-antibiotics Print Email + Font - Font Environmental Scientists Find Antibiotics, Bacteria, Resistance Genes

  7. Analysis of the Arabidopsis NAC gene superfamily in plant development 

    E-Print Network [OSTI]

    Alvarado Chavez, Veria Ysabel

    2009-05-15

    There are a vast number of transcription factors that regulate plant growth and development. The NAC gene superfamily is one of the largest families of transcription factors in the plant kingdom. NAC gene expression profiles using Affymetrix ATH1...

  8. SVM-RFE With MRMR Filter for Gene Selection

    E-Print Network [OSTI]

    Mundra, Piyushkumar A.

    We enhance the support vector machine recursive feature elimination (SVM-RFE) method for gene selection by incorporating a minimum-redundancy maximum-relevancy (MRMR) filter. The relevancy of a set of genes are measured ...

  9. Effects of Pinealectomy on Hypothalamic Metabolic and Clock Gene Rhythms 

    E-Print Network [OSTI]

    Clauson, Amanda

    2006-07-11

    the validity of the neuroendocrine loop model by suggesting that although melatonin administration affects overt clock function, (Lu and Cassone, 1993) it has no effect on the transcription of clock genes (Yasuo et al., 2002). Thus, expression of these genes...

  10. From Biophysics to Evolutionary Genetics: Statistical Aspects of Gene Regulation

    E-Print Network [OSTI]

    Lässig, Michael

    , that it is not the only mode of gene interactions. Especially in eukaryotes, additional regulation mechanims involving

  11. QB1 - Stochastic Gene Regulation Munsky, Brian [Los Alamos National

    Office of Scientific and Technical Information (OSTI)

    FACILITIES; FLUCTUATIONS; GENE REGULATION; KINETICS; QUANTIZATION; SIMULATION; SWITCHES Summaries of this presentation are: (1) Stochastic fluctuations or 'noise' is present...

  12. LEARNING TO COMBINE DECISIONS FROM MULTIPLE MAMMOGRAPHY VIEWS Alan Joseph Bekker

    E-Print Network [OSTI]

    Goldberger, Jacob

    describe a two-step classification method that is based on a view-level decision, implemented by a logistic model. Our method was evaluated on a standardized digital database for screening mammography (DDSM views. Index Terms-- Mammography, Microcalcifications, Computer-aided diagnosis 1. INTRODUCTION

  13. Prairie View A&M University Whole Campus Energy Report Update 

    E-Print Network [OSTI]

    Haberl, J. S.; Claridge, D. E.; Turner, W. D.

    1992-01-01

    Prairie View A&M University started a large scale energy management program in 1987 and 1988. This updated report presents an analysis of whole-campus energy consumption at the Prairie View A&M Campus where whole-campus indices were developed...

  14. Model-Based Multi-view Fusion of Cinematic Flow and Optical Imaging

    E-Print Network [OSTI]

    Paragios, Nikos

    Model-Based Multi-view Fusion of Cinematic Flow and Optical Imaging Mickael Savinaud1,2,3 , Martin-view Fusion of Cinematic Flow and Optical Imaging 669 optical imaging devices are now able to image does not enable cinematic acquisition. The use of temporal information involves either animal tracking

  15. Reconstructions in limited-view thermoacoustic tomography Yuan Xu and Lihong V. Wanga)

    E-Print Network [OSTI]

    Kuchment, Peter

    Reconstructions in limited-view thermoacoustic tomography Yuan Xu and Lihong V. Wanga) Optical for publication 9 December 2003; published 11 March 2004 The limited-view problem is studied for thermoacoustic of Physicists in Medicine. DOI: 10.1118/1.1644531 Key words: thermoacoustic tomography, photoacoustic tomography

  16. ROBUST AND UNBIASED FOREGROUND / BACKGROUND ENERGY FOR MULTI-VIEW STEREO

    E-Print Network [OSTI]

    Wong, Kenneth K.Y.

    maps even in the absence of the photo-consistency energy. To the best of our #12;knowledgeROBUST AND UNBIASED FOREGROUND / BACKGROUND ENERGY FOR MULTI-VIEW STEREO Zhihu Chen and Kwan-Yee K@cs.hku.hk, kykwong@cs.hku.hk Keywords: Multi-View Stereo, Photo-Consistency Energy, Foreground / Background Energy

  17. The Implementation of Mobile Bank Usage from marketing point of view of bank managers in Jordan.

    E-Print Network [OSTI]

    The Implementation of Mobile Bank Usage from marketing point of view of bank managers in Jordan. The study aims at determine the effect of the implementation of Mobile Bank Usage from marketing point between the Implementation of Mobile Bank Usage from marketing point of view of bank managers in Jordan

  18. LabVIEW and G as a Computing Language Course Mukkai Krishnamoorthy and Sibylle Schupp,

    E-Print Network [OSTI]

    Bystroff, Chris

    VIEW project. We have to calculate the (stops shortly) g.c.d. of two numbers. (Sighs.) LabVIEW is a cool:=a; return || Figure 1: Greatest Common Divisor Algorithm Ms. Engi Neer: This is cool. I remember my CS­1 understand the algorithm I can start my programming. Here is my front panel. (Opens a new front panel

  19. LabVIEW and G as a Computing Language Course Mukkai Krishnamoorthy and Sibylle Schupp,

    E-Print Network [OSTI]

    Bystroff, Chris

    VIEW project. We have to calculate the (stops shortly) g.c.d. of two numbers. (Sighs.) LabVIEW is a cool:=a; return || Figure 1: Greatest Common Divisor Algorithm Ms. Engi Neer: This is cool. I remember my CS-1 understand the algorithm I can start my programming. Here is my front panel. (Opens a new front panel

  20. You are here: Home / News / 3D view of 1D nanostructures More services

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    create tool to put the lid on solar power fluctuations Variability law for solar panels News 3D view of 1You are here: Home / News / 3D view of 1D nanostructures Share More services Related Links of nanogenerators based on GaN nanowires, for powering of self-powered nanodevices. This story is reprinted from

  1. Design and Selection of Materialized Views in a Data Warehousing Environment: A Case Study

    E-Print Network [OSTI]

    Song, Il-Yeol

    , including query access frequencies, base-data update frequencies, query access costs, view maintenance costs views, the total cost of the maintenance, storage and query processing of the system is optimized incur a high maintenance cost. Furthermore, for a system with limited storage space and

  2. An Analysis of Document Viewing Patterns of Web Search Engine Users

    E-Print Network [OSTI]

    Jansen, James

    the concepts of Web results page and Web page viewing patterns by users of Web search engines. It presents for Web usage mining. The authors also present the results of a temporal of analysis of Web page viewing how users interact with Web search engines. There are also reports on the number of result pages

  3. The Universe Viewed in Gamma-Rays 1 Properties of Gamma-ray Bursts Localized by

    E-Print Network [OSTI]

    Enomoto, Ryoji

    The Universe Viewed in Gamma-Rays 1 Properties of Gamma-ray Bursts Localized by the HETE-2 and localize Gamma-ray bursts (GRBs) in wide field of view. HETE-2 have been localized about 20 GRBs per year hours after the burst. 1. The High Energy Transient Explorer 2 Gamma-ray burst (GRB) is the most

  4. MedView: A Declarative Approach to Evidence-Based Medicine

    E-Print Network [OSTI]

    Torgersson, Olof

    MedView: A Declarative Approach to Evidence-Based Medicine Göran Falkman Department of Computer Abstract. MedView is a project that meets the challenges of evidence-based oral medicine by providing", John Naisbitt exclaimed in 1982 [1]. This is perhaps particularly true for clinical medicine

  5. Painting Objects with View-dependent Effects Cindy M. Grimm, Michael Kowalski

    E-Print Network [OSTI]

    Grimm, Cindy

    Painting Objects with View-dependent Effects Cindy M. Grimm, Michael Kowalski Washington Univ. in St. Louis Abstract We present a system for painting on an object in a view-dependent way. The user creates paintings of the object from various camera positions to produce a texture map which changes

  6. Materialized Views in Probabilistic Databases For Information Exchange and Query Optimization

    E-Print Network [OSTI]

    Thrun, Sebastian

    probabilistic data contain correlations between tuples, and the current approach is to capture these correla (BID) table. Not all views can be rep- resented as BID tables and so we propose a novel partial processing on probabilistic data, we can ignore the lineage and use materialized views to more efficiently

  7. Estimation and Detection of Multivariate Gene Regulatory Relationships 

    E-Print Network [OSTI]

    Chen, Ting

    2013-09-18

    and canalyzing genes like p53 and DUSP1 from real data sets, respectively. This indicates that our methodology could serve as a promising tool for the detection of potential gene regulatory relationships and canalyzing genes. In one word, this dissertation...

  8. Evolution by gene duplication: an update Jianzhi Zhang

    E-Print Network [OSTI]

    Zhang, Jianzhi

    Evolution by gene duplication: an update Jianzhi Zhang Department of Ecology and Evolutionary The importance of gene duplication in supplying raw genetic material to biological evolution has been recog- tions, and what role does gene duplication play in the evolution of genomes and organisms? Detailed

  9. Efficient and Robust Algorithms for Statistical Inference in Gene Regulatory Networks 

    E-Print Network [OSTI]

    Noor, Amina

    2013-12-10

    Inferring gene regulatory networks (GRNs) is of profound importance in the ?eld of computational biology and bioinformatics. Understanding the gene-gene and gene- transcription factor (TF) interactions has the potential of providing an insight...

  10. Towards an informative mutant phenotype for every bacterial gene

    SciTech Connect (OSTI)

    Deutschbauer, Adam; Price, Morgan N.; Wetmore, Kelly M.; Tarjan, Daniel R.; Xu, Zhuchen; Shao, Wenjen; Leon, Dacia; Arkin, Adam P.; Skerker, Jeffrey M.

    2014-08-11

    Mutant phenotypes provide strong clues to the functions of the underlying genes and could allow annotation of the millions of sequenced yet uncharacterized bacterial genes. However, it is not known how many genes have a phenotype under laboratory conditions, how many phenotypes are biologically interpretable for predicting gene function, and what experimental conditions are optimal to maximize the number of genes with a phenotype. To address these issues, we measured the mutant fitness of 1,586 genes of the ethanol-producing bacterium Zymomonas mobilis ZM4 across 492 diverse experiments and found statistically significant phenotypes for 89% of all assayed genes. Thus, in Z. mobilis, most genes have a functional consequence under laboratory conditions. We demonstrate that 41% of Z. mobilis genes have both a strong phenotype and a similar fitness pattern (cofitness) to another gene, and are therefore good candidates for functional annotation using mutant fitness. Among 502 poorly characterized Z. mobilis genes, we identified a significant cofitness relationship for 174. For 57 of these genes without a specific functional annotation, we found additional evidence to support the biological significance of these gene-gene associations, and in 33 instances, we were able to predict specific physiological or biochemical roles for the poorly characterized genes. Last, we identified a set of 79 diverse mutant fitness experiments in Z. mobilis that are nearly as biologically informative as the entire set of 492 experiments. Therefore, our work provides a blueprint for the functional annotation of diverse bacteria using mutant fitness.

  11. Identification of novel lung genes in bronchial epithelium by serial analysis of gene Kim M. Lonergan*1

    E-Print Network [OSTI]

    Ng, Raymond T.

    1 Identification of novel lung genes in bronchial epithelium by serial analysis of gene expression of human bronchial epithelium should provide a basis for studying lung diseases including cancer. We have deduced global gene expression profiles of bronchial epithelium and lung parenchyma, based upon a vast

  12. Global prevalence and distribution of genes and microorganisms involved in mercury methylation

    SciTech Connect (OSTI)

    Podar, Mircea; Gilmour, C C; Brandt, Craig C; Bullock, Allyson L; Brown, Steven D; Crable, Bryan R; Palumbo, Anthony Vito; Somenahally, Anil C; Elias, Dwayne A

    2015-01-01

    Mercury methylation produces the neurotoxic, highly bioaccumulative methylmercury (MeHg). Recent identification of the methylation genes (hgcAB) provides the foundation for broadly evaluating microbial Hg-methylation potential in nature without making explicit rate measurements. We queried hgcAB diversity and distribution in all available microbial metagenomes, encompassing most environments. The genes were found in nearly all anaerobic, but not in aerobic, environments including oxygenated layers of the open ocean. Critically, hgcAB was effectively absent in ~1500 human microbiomes, suggesting a low risk of endogenous MeHg production. New potential methylation habitats were identified, including invertebrate guts, thawing permafrost, coastal dead zones , soils, sediments, and extreme environments, suggesting multiple routes for MeHg entry into food webs. Several new taxonomic groups potentially capable of Hg-methylation emerged, including lineages having no cultured representatives. We begin to address long-standing evolutionary questions about Hg-methylation and ancient carbon fixation mechanisms while generating a new global view of Hg-methylation potential.

  13. Global prevalence and distribution of genes and microorganisms involved in mercury methylation

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Podar, Mircea; Gilmour, C C; Brandt, Craig C; Bullock, Allyson L; Brown, Steven D; Crable, Bryan R; Palumbo, Anthony Vito; Somenahally, Anil C; Elias, Dwayne A

    2015-01-01

    Mercury methylation produces the neurotoxic, highly bioaccumulative methylmercury (MeHg). Recent identification of the methylation genes (hgcAB) provides the foundation for broadly evaluating microbial Hg-methylation potential in nature without making explicit rate measurements. We queried hgcAB diversity and distribution in all available microbial metagenomes, encompassing most environments. The genes were found in nearly all anaerobic, but not in aerobic, environments including oxygenated layers of the open ocean. Critically, hgcAB was effectively absent in ~1500 human microbiomes, suggesting a low risk of endogenous MeHg production. New potential methylation habitats were identified, including invertebrate guts, thawing permafrost, coastal dead zones , soils, sediments,more »and extreme environments, suggesting multiple routes for MeHg entry into food webs. Several new taxonomic groups potentially capable of Hg-methylation emerged, including lineages having no cultured representatives. We begin to address long-standing evolutionary questions about Hg-methylation and ancient carbon fixation mechanisms while generating a new global view of Hg-methylation potential.« less

  14. Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product

    SciTech Connect (OSTI)

    Santhanam, U.; Ray, A.; Sehgal, P.B. (Rockefeller Univ., New York, NY (United States))

    1991-09-01

    The aberrant overexpression of interleukin 6 (IL-6) is implicated as an autocrine mechanism in the enhanced proliferation of the neoplastic cell elements in various B- and T-cell malignancies and in some carcinomas and sarcomas; many of these neoplasms have been shown to be associated with a mutated p53 gene. The possibility that wild-type (wt) p53, a nuclear tumor-suppressor protein, but not its transforming mutants might serve to repress IL-6 gene expression was investigated in HeLa cells. The authors transiently cotransfected these cells with constitutive cytomegalovirus (CMV) enhancer/promoter expression plasmids overproducing wt or mutant human or murine p53 and with appropriate chloramphenicol acetyltransferase (CAT) reporter plasmids containing the promoter elements of human IL-6, c-fos, or {beta}-actin genes or of porcine major histocompatibility complex (MHC) class I gene in pN-38 to evaluate the effect of the various p53 species on these promoters. These observations identify transcriptional repression as a property of p53 and suggest that p53 and RB may be involved as transcriptional repressors in modulating IL-6 gene expression during cellular differentiation and oncogenesis.

  15. Optic for an endoscope/borescope having high resolution and narrow field of view

    DOE Patents [OSTI]

    Stone, Gary F.; Trebes, James E.

    2003-10-28

    An optic having optimized high spatial resolution, minimal nonlinear magnification distortion while at the same time having a limited chromatic focal shift or chromatic aberrations. The optic located at the distal end of an endoscopic inspection tool permits a high resolution, narrow field of view image for medical diagnostic applications, compared to conventional optics for endoscopic instruments which provide a wide field of view, low resolution image. The image coverage is over a narrow (<20 degrees) field of view with very low optical distortion (<5% pin cushion or barrel distortion. The optic is also optimized for best color correction as well as to aid medical diagnostics.

  16. Merguerian, Charles, 1986a, Tunnel vision -A deep view of the bedrock geology of New York City (NYC).

    E-Print Network [OSTI]

    Merguerian, Charles

    Merguerian, Charles, 1986a, Tunnel vision - A deep view of the bedrock geology of New York City This Abstract: Merguerian, Charles, 1986a, Tunnel vision - A deep view of the bedrock geology of New York City

  17. Jefferson Lab scientist puts intriguing view on spin of the proton...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    scientist puts intriguing view on spin of the proton April 17, 2007 Newport News, Va. - A new result from the HERMES experiment at The German Electron Synchrotron DESY indicates...

  18. Computing point-of-view : modeling and simulating judgments of taste

    E-Print Network [OSTI]

    Liu, Xinyu Hugo, 1979-

    2006-01-01

    People have rich points-of-view that afford them the ability to judge the aesthetics of people, things, and everyday happenstance; yet viewpoint has an ineffable quality that is hard to articulate in words, let alone capture ...

  19. NATURE NANOTECHNOLOGY | VOL 9 | JANUARY 2014 | www.nature.com/naturenanotechnology 11 news & views

    E-Print Network [OSTI]

    NATURE NANOTECHNOLOGY | VOL 9 | JANUARY 2014 | www.nature.com/naturenanotechnology 11 news & views Nanotechnology, Andrew Turberfield and colleagues at the University of Oxford and Warwick Medical School now show

  20. The Impact of the CEO's View of Risk on Turnover and the Value of Equity 

    E-Print Network [OSTI]

    Campbell, Timothy Colin

    2011-10-21

    Recent theory predicts that two factors influencing the CEO’s view of risk, overconfidence and debt-like compensation, have implications for CEO forced turnover and firm equity value, respectively. We test each of these ...

  1. Managing Applicants Reference Guide Quick easy steps of Viewing Applications and Changing Workflow States

    E-Print Network [OSTI]

    Powers, Robert

    Change* Within a search only the hiring managers assigned to that requisition, or EAD Users and HR Users may change workflow states. Hiring managers actionsManaging Applicants Reference Guide Quick easy steps of Viewing Applications

  2. 176 nature nanotechnology | VOL 5 | MARCH 2010 | www.nature.com/naturenanotechnology news & views

    E-Print Network [OSTI]

    Buratto, Steve

    176 nature nanotechnology | VOL 5 | MARCH 2010 | www.nature.com/naturenanotechnology news & views P humidity. Writing in Nature Nanotechnology, Saeed Moghaddam, Mark Shannon and colleagues1 at the University

  3. DOE Solicits Views on the Implementation of Large-Capacity Clothes...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Large-Capacity Clothes Washer Waivers DOE Solicits Views on the Implementation of Large-Capacity Clothes Washer Waivers November 30, 2010 - 10:56am Addthis The Department of...

  4. A manual procedure for assembly sequence planning based on the exploded view method 

    E-Print Network [OSTI]

    Rivero, Andres R

    1995-01-01

    This thesis covers the development of a manual planning procedure based on the computerized method of exploded views to generate an optimal or near-optimal assembly sequence. Care has been taken to minimize iterative and ...

  5. A State Regulator's View of 'PURPA' And Its Impact on Energy Conservation in the Industrial Sector 

    E-Print Network [OSTI]

    Williams, M. L.

    1981-01-01

    The purpose of my comments this afternoon is to share with you my views concerning the status of the Public Utility Regulatory Policies Act (PURPA), and how some of the rate standards contained in the Act may affect energy conservation...

  6. GPU-based Scalable Volumetric Reconstruction for Multi-view Stereo

    SciTech Connect (OSTI)

    Kim, H; Duchaineau, M; Max, N

    2011-09-21

    We present a new scalable volumetric reconstruction algorithm for multi-view stereo using a graphics processing unit (GPU). It is an effectively parallelized GPU algorithm that simultaneously uses a large number of GPU threads, each of which performs voxel carving, in order to integrate depth maps with images from multiple views. Each depth map, triangulated from pair-wise semi-dense correspondences, represents a view-dependent surface of the scene. This algorithm also provides scalability for large-scale scene reconstruction in a high resolution voxel grid by utilizing streaming and parallel computation. The output is a photo-realistic 3D scene model in a volumetric or point-based representation. We demonstrate the effectiveness and the speed of our algorithm with a synthetic scene and real urban/outdoor scenes. Our method can also be integrated with existing multi-view stereo algorithms such as PMVS2 to fill holes or gaps in textureless regions.

  7. A View of Manufacturing Through 3D Glasses | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    a.m. Eastern Time, I will be moderating a Google+ Video Hangout with top experts in the additive manufacturing space, which you can view on GE Global Research Live. I will be...

  8. Student Course Survey Reports How to view your SCS reports in PeopleSoft

    E-Print Network [OSTI]

    Stoiciu, Mihai

    1 Student Course Survey Reports How to view your SCS reports in PeopleSoft Your current and past SCS reports are now available to you through the Williams Student Records system. SCS quantitative reports are no longer printed

  9. Ecology in Africa: a view from the past for informing the future

    E-Print Network [OSTI]

    Martins, Dino J.

    2013-01-01

    ISSN 1948?6596  Ecology in Africa: a view from the past for http://www.springer.com/  “Africa’s  natural  habitats  are the  ecology  of  Africa…”.   These opening sentences from 

  10. Transmission System Expansion Plans in View Point of Deterministic, Probabilistic and Security Reliability Criteria

    E-Print Network [OSTI]

    Transmission System Expansion Plans in View Point of Deterministic, Probabilistic and Security reliability criterion, probabilistic reliability criterion and security criterion based on N- contingency control system as well as reasonable strength of grid originally. Because investment for power system

  11. Cellulosic Biofuels: Expert Views on Prospects for Advancement and Jeffrey Keisler

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Cellulosic Biofuels: Expert Views on Prospects for Advancement Erin Baker and Jeffrey Keisler funding and the likelihood of achieving advances in cellulosic biofuel technologies. While in collecting more information on this technology. Keywords: Biofuels; Technology R&D; Uncertainty

  12. Headteachers’ views on the inclusion of students with special educational needs in Taiwan 

    E-Print Network [OSTI]

    Chang, Chia-Wen

    2011-07-04

    The main aim of this research is to offer a sociological analysis of Taiwanese headteachers’ views of the inclusion of students with special educational needs (SEN) in mainstream schools. Taiwan is a country which combines ...

  13. Intrinsic modulation of ENSO predictability viewed through a local Lyapunov lens

    E-Print Network [OSTI]

    Wittenberg, Andrew

    Intrinsic modulation of ENSO predictability viewed through a local Lyapunov lens Christina magnitude, frequency, and physical evolution. Local Lyapunov exponents (LLEs) estimated from the monthly Predictability Á Local Lyapunov exponents 1 Introduction The limits of predictability of the state

  14. Wide Field of View Compressive Light Field Display using a Multilayer Architecture and Tracked Viewers

    E-Print Network [OSTI]

    Maimone, Andrew

    In this paper, we discuss a simple extension to existing compressive multilayer light field displays that greatly extends their field of view and depth of field. Rather than optimizing these displays to create a moderately ...

  15. Automated Deduction: A Technological Point of View Peter Baumgartner, Ingo Dahn, Jrgen Dix, Ulrich Furbach,

    E-Print Network [OSTI]

    Baumgartner, Peter

    1 Automated Deduction: A Technological Point of View Peter Baumgartner, Ingo Dahn, Jürgen Dix called ILF, developed by I. Dahn within the German focus program on Deduction, was able to translate

  16. View the archive at http://blogs. nature.com/nature/journalclub

    E-Print Network [OSTI]

    Conrad, Clint

    View the archive at http://blogs. nature.com/nature/journalclub Petr Svoboda Institute of Molecular of Standards and Technology in Gaithersburg, Maryland, and her team probed the three-dimensional magnetic

  17. California’s Energy Future: The View to 2050 - Summary Report

    E-Print Network [OSTI]

    Yang, Christopher

    2011-01-01

    View to 2050 Laser Fusion Energy a Potential Game Changerworld leader in laser fusion energy—a potential game changera Laser Inertial Fusion Energy (LIFE) power plant would be

  18. UFilter: A Lightweight XML View Update Checker Ling Wang, Elke A. Rundensteiner and Murali Mani

    E-Print Network [OSTI]

    U­Filter: A Lightweight XML View Update Checker Ling Wang, Elke A. Rundensteiner and Murali Mani 1997 year Simon & Schuster Inc. A02 Prentice­Hall Inc. B01 McGraw­Hill

  19. nature methods | VOL.7 NO.7 | JULY 2010 | 505 news and views

    E-Print Network [OSTI]

    Cai, Long

    of the fly's teth- ered flight. They found that active flying (as opposed to passive viewing) altered data and ablation studies in larger flies, including house flies and blow flies, has identified neurons

  20. DOE Zero Energy Ready Home Case Study: Clifton View Homes, Marine...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Marine Drive and Port Hadlcok, Coupeville and Port Hadlock WA DOE Zero Energy Ready Home Case Study: Clifton View Homes, Marine Drive and Port Hadlcok, Coupeville and Port Hadlock...

  1. Installing and Using VMWare View Client for Windows This document describes how to get up and running with View if you use a Windows

    E-Print Network [OSTI]

    Neirotti, Juan Pablo

    to carry out the installation steps once per device. 1. Go to VMWare View and download the relevant install will need to delete and re type. #12;4 3. Once you have clicked Connect, you will be prompted to enter your defaults, such as your Outlook signature, any Internet browser favourites etc. These will be saved

  2. Interactions of tropical synoptic-scale features as viewed from satellite 

    E-Print Network [OSTI]

    Winton, Susan Elizabeth

    1991-01-01

    INTERACTIONS OF TROPICAL SYNOPTIC-SCALE FEATURES AS VIEWED FROM SATELLITE Thesis by SUSAN ELIZABETH WINTON Submitted to tbe Office of Graduate Studies of Texas ARM University in partial fulfillment of the requirements for the degree... of MASTER OF SCIENCE December 1991 Major Subject: Meteorology INTERACTIONS QF TROPICAL SYNOPTIC-SCALE FEATURES AS VIEWED FROM SATELLITE A Thesis by SUSAN ELIZABETH WINTON Approved as to style and content by: James P. McGuirk (Chair of Committee...

  3. Gene Calling Standards (GSC8 Meeting)

    ScienceCinema (OSTI)

    Kyrpides, Nikos [Genome Biology Program, DOE JGI

    2011-04-28

    The Genomic Standards Consortium was formed in September 2005. It is an international, open-membership working body which promotes standardization in the description of genomes and the exchange and integration of genomic data. The 2009 meeting was an activity of a five-year funding "Research Coordination Network" from the National Science Foundation and was organized held at the DOE Joint Genome Institute with organizational support provided by the JGI and by the University of California - San Diego. Nikos Kyrpides of the DOE Joint Genome Institute discusses gene calling standards at the Genomic Standards Consortium's 8th meeting at the DOE JGI in Walnut Creek, Calif. on Sept. 10, 2009.

  4. Algorithms for Gene Clustering Analysis on Genomes 

    E-Print Network [OSTI]

    Yi, Gang Man

    2012-07-16

    CLUSTERING ANALYSIS ON GENOMES A Dissertation by GANG MAN YI Submitted to the O ce of Graduate Studies of Texas A&M University in partial ful llment of the requirements for the degree of DOCTOR OF PHILOSOPHY May 2011 Major Subject: Computer Science... ALGORITHMS FOR GENE CLUSTERING ANALYSIS ON GENOMES A Dissertation by GANG MAN YI Submitted to the O ce of Graduate Studies of Texas A&M University in partial ful llment of the requirements for the degree of DOCTOR OF PHILOSOPHY Approved by: Chair...

  5. Surface enhanced Raman gene probe and methods thereof

    DOE Patents [OSTI]

    Vo-Dinh, T.

    1998-02-24

    The subject invention disclosed is a new gene probe biosensor and methods based on surface enhanced Raman scattering (SERS) label detection. The SER gene probe biosensor comprises a support means, a SER gene probe having at least one oligonucleotide strand labeled with at least one SERS label, and a SERS active substrate disposed on the support means and having at least one of the SER gene probes adsorbed thereon. Biotargets such as bacterial and viral DNA, RNA and PNA are detected using a SER gene probe via hybridization to oligonucleotide strands complementary to the SER gene probe. The support means includes a fiberoptic probe, an array of fiberoptic probes for performance of multiple assays and a waveguide microsensor array with charge-coupled devices or photodiode arrays. 18 figs.

  6. Surface enhanced Raman gene probe and methods thereof

    DOE Patents [OSTI]

    Vo-Dinh, T.

    1998-09-29

    The subject invention disclosed herein is a new gene probe biosensor and methods based on surface enhanced Raman scattering (SERS) label detection. The SER gene probe biosensor comprises a support means, a SER gene probe having at least one oligonucleotide strand labeled with at least one SERS label, and a SERS active substrate disposed on the support means and having at least one of the SER gene probes adsorbed thereon. Biotargets such as bacterial and viral DNA, RNA and PNA are detected using a SER gene probe via hybridization to oligonucleotide strands complementary to the SER gene probe. The support means supporting the SERS active substrate includes a fiberoptic probe, an array of fiberoptic probes for performance of multiple assays and a waveguide microsensor array with charge-coupled devices or photodiode arrays. 18 figs.

  7. Surface enhanced Raman gene probe and methods thereof

    DOE Patents [OSTI]

    Vo-Dinh, T.

    1998-07-21

    The subject invention disclosed is a new gene probe biosensor and methods based on surface enhanced Raman scattering (SERS) label detection. The SER gene probe biosensor comprises a support means, a SER gene probe having at least one oligonucleotide strand labeled with at least one SERS label, and a SERS active substrate disposed on the support means and having at least one of the SER gene probes adsorbed. Biotargets such as bacterial and viral DNA, RNA and PNA are detected using a SER gene probe via hybridization to oligonucleotide strands complementary to the SER gene probe. The support means supporting the SERS active substrate includes a fiberoptic probe, an array of fiberoptic probes for performance of multiple assays and a waveguide microsensor array with charge-coupled devices or photodiode arrays. 18 figs.

  8. Gene clustering pattern, promoter architecture, and gene expression stability in eukaryotic genomes

    E-Print Network [OSTI]

    Zhang, Jianzhi

    . We hypothe- sized that upstream distance and orientation (head-to-head or head-to-tail) are important upstream distance tend to have low gene expression variability, and their promoter is flanked by strongly positioned nucleosomes and tends to have low nucleosome occupancy. These observations suggest that in vivo

  9. Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping

    E-Print Network [OSTI]

    Mackay, Trudy F.C.

    University, Boston, MA 02111, United States b Department of Genetics and W.M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695-7614, United States Received 4 April 2006, short-lived animal models are essential to identifying the mechanisms and genes that affect the rate

  10. Engineering disease resistance with pectate lyase-like genes

    DOE Patents [OSTI]

    Vogel, John; Somerville, Shauna

    2005-03-08

    A mutant gene coding for pectate lyase and homologs thereof is provided, which when incorporated in transgenic plants effect an increased level disease resistance in such plants. Also is provided the polypeptide sequence for the pectate lyase of the present invention. Methods of obtaining the mutant gene, producing transgenic plants which include the nucleotide sequence for the mutant gene and producing improved disease resistance in a crop of such transgenic plants are also provided.

  11. Measuring semantic similarities by combining gene ontology annotations...

    Office of Scientific and Technical Information (OSTI)

    the members functionally and show that this grouping could facilitate functional characterization of genes in these families. Conclusions: Using NETSIM as an example, we...

  12. Measuring semantic similarities by combining gene ontology annotations...

    Office of Scientific and Technical Information (OSTI)

    the members functionally and show that this grouping could facilitate functional characterization of genes in these families. Conclusions: Using NETSIM as an example, we...

  13. Modulation of histone methylation and MLH1 gene silencing by...

    Office of Scientific and Technical Information (OSTI)

    LIFE SCIENCES; ARGININE; CARCINOGENS; CHROMIUM; DNA DAMAGES; GENES; HUMAN POPULATIONS; LUNGS; LYSINE; METHYLATION; NEOPLASMS; OCCUPATIONAL EXPOSURE; PROMOTERS Word Cloud More Like...

  14. High-throughput comparison of gene fitness among related bacteria

    E-Print Network [OSTI]

    2012-01-01

    5096–5108. 36. Macnab RM: How bacteria assemble. Annu Revgene fitness among related bacteria. BMC Genomics 2012 13:gene fitness among related bacteria Rocio Canals 1 , Xiao-

  15. Gibbs Sampling for Gene Cis-Regulatory Elements

    E-Print Network [OSTI]

    Newberg, Heidi

    : "Bayesian computational approaches for gene regulation studies of bioethanol and biohydrogen production ... for the understanding of cell function, differentiation, and pathology ... because the elements affect both the products

  16. Genomics, Gene Expression and Other Studies in Soybean Rust

    E-Print Network [OSTI]

    Posada-Buitrago, Martha Lucia

    2005-01-01

    Joint Genome Institute Genomics, Gene Expression and otherRust Martha Lucía Posada-Buitrago Ph.D Genomics DivisionEvolutionary Genomics DOE- Joint Genome Institute Lawrence

  17. Functional Ecological Gene Networks to Reveal the Changes Among...

    Office of Scientific and Technical Information (OSTI)

    network structure among different microbial speciespopulations. Here, a novel random matrix theory (RMT)-based conceptual framework for identifying functional ecological gene...

  18. MAVTgsa: An R Package for Gene Set (Enrichment) Analysis

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Chien, Chih-Yi; Chang, Ching-Wei; Tsai, Chen-An; Chen, James J.

    2014-01-01

    Gene set analysis methods aim to determine whether an a priori defined set of genes shows statistically significant difference in expression on either categorical or continuous outcomes. Although many methods for gene set analysis have been proposed, a systematic analysis tool for identification of different types of gene set significance modules has not been developed previously. This work presents an R package, called MAVTgsa, which includes three different methods for integrated gene set enrichment analysis. (1) The one-sided OLS (ordinary least squares) test detects coordinated changes of genes in gene set in one direction, either up- or downregulation. (2)more »The two-sided MANOVA (multivariate analysis variance) detects changes both up- and downregulation for studying two or more experimental conditions. (3) A random forests-based procedure is to identify gene sets that can accurately predict samples from different experimental conditions or are associated with the continuous phenotypes. MAVTgsa computes the P values and FDR (false discovery rate) q -value for all gene sets in the study. Furthermore, MAVTgsa provides several visualization outputs to support and interpret the enrichment results. This package is available online. « less

  19. Mutator gene and hereditary non-polyposis colorectal cancer

    DOE Patents [OSTI]

    de la Chapelle, Albert (Helsingfors, FI); Vogelstein, Bert (Baltimore, MD); Kinzler, Kenneth W. (Baltimore, MD)

    2008-02-05

    The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.

  20. Designer gene circuits for basic science, engineering, and medicine /

    E-Print Network [OSTI]

    Prindle, Arthur

    2014-01-01

    Programmable Probiotics . . . . . . . . . . .Chapter 5 Programmable Probiotics: Gene circuit chaperonesFigure 5.1: PROP-Z probiotics for noninvasive cancer

  1. Listening to the noise: random fluctuations reveal gene network...

    Office of Scientific and Technical Information (OSTI)

    Title: Listening to the noise: random fluctuations reveal gene network parameters The cellular environment is abuzz with noise. The origin of this noise is attributed to the...

  2. ARIMA Models versus Gene Expression Programming In Precipitation Modeling

    E-Print Network [OSTI]

    Fernandez, Thomas

    ARIMA Models versus Gene Expression Programming In Precipitation Modeling ALINA BRBULESCU and ELENA, Precipitation 1 Introduction Time series are ubiquitous in the real world. They are usually generated

  3. Variant translocation of the bcl-2 gene to immunoglobulin. lambda. light chain gene in chronic lymphocytic leukemia

    SciTech Connect (OSTI)

    Adachi, M.; Cossman, J.; Longo, D.; Croce, C.M.; Tsujimoto, Y. (Wistar Institute of Anatomy and Biology, Philadelphia, PA (USA))

    1989-04-01

    The bcl-2 gene has been identified as a gene directly involved in the consistent chromosome translocation t(14;18), which is found in {approx} 90% of human follicular lymphoma cases, and is a prime candidate for the oncogene playing a crucial role in follicular lymphomagenesis. In this paper, the authors describe a case of chronic lymphocytic leukemia showing the juxtaposition of the bcl-2 gene on chromosome 18 to immunoglobulin {lambda} light chain (Ig{lambda}) gene on chromosome 22 in a head-to-head configuration. Sequencing analysis of the joining site of the bcl-2 gene and Ig{lambda} gene has shown that the breakpoint is within the 5{prime} flanking region of the bcl-2 gene and about 2.2 kilobases 5{prime} to the joining segment of Ig{lambda} locus in a germ-line configuration. The extranucleotide, commonly appearing at the joining site of the t(14;18) translocation involving the IgH locus, is absent from the joining site of bcl-2 and Ig{lambda}. The lack of extranucleotide suggests that the juxtaposition of the bcl-2 and Ig{lambda} genes occurred during physiological rearrangement of the Ig{lambda} gene since it has been shown that the rearrangement of the Ig{lambda} locus is not accompanied by extranucleotides.

  4. Gene expression profiles of Nitrosomonas europaea, an obligate chemolitotroph

    SciTech Connect (OSTI)

    Daniel J. Arp

    2005-05-25

    Nitrosomonas europaea is an aerobic lithoautotrophic bacterium that uses ammonia (NH3) as its energy source. As a nitrifier, it is an important participant in the nitrogen cycle, which can also influence the carbon cycle. The focus of this work was to explore the genetic structure and mechanisms underlying the lithoautotrophic growth style of N. europaea. Whole genome gene expression: The gene expression profile of cells in exponential growth and during starvation was analyzed using microarrays. During growth, 98% of the genes increased in expression at least two fold compared to starvation conditions. In growing cells, approximately 30% of the genes were expressed eight fold higher, Approximately 10% were expressed more than 15 fold higher. Approximately 3% (91 genes) were expressed to more than 20 fold of their levels in starved cells. Carbon fixation gene expression: N. europaea fixes carbon via the Calvin-Benson-Bassham (CBB) cycle via a type I ribulose bisphosphate carboxylase/oxygenase (RubisCO). This study showed that transcription of cbb genes was up-regulated when the carbon source was limited, while amo, hao and other energy harvesting related genes were down-regulated. Iron related gene expression: Because N. europaea has a relatively high content of hemes, sufficient Fe must be available in the medium for it to grow. The genome revealed that approximately 5% of the coding genes in N. europaea are dedicated to Fe transport and assimilation. Nonetheless, with the exception of citrate biosynthesis genes, N. europaea lacks genes for siderophore production. The Fe requirements for growth and the expression of the putative membrane siderophore receptors were determined. The N. europaea genome has over 100 putative genes ({approx}5% of the coding genes) related to Fe uptake and its siderophore receptors could be grouped phylogenetically in four clusters. Fe related genes, such as a number of TonB-dependent Fe-siderophore receptors for ferrichrome and enterobactin, and diffusion protein OmpC were expressed to higher levels under Fe limitation. N. europaea has a high Fe requirement and under Fe limiting conditions (0.2 {micro}M), is capable to assimilate up to 70% of the available Fe without the ability to produce siderophores.

  5. EXCAVATOR: A Computer Program for Efficiently Mining Gene-Expression Data

    E-Print Network [OSTI]

    EXCAVATOR: A Computer Program for Efficiently Mining Gene-Expression Data Dong Xu 1,* , Victor: gene expression, gene regulation, biological data mining, clustering, minimum spanning tree, Java GUI@ornl.gov. #12;ABSTRACT Massive gene-expression data are generated using microarrays, and clustering gene

  6. Uncorrected Proof Copy Finding Genes by Using Computational Tools 85

    E-Print Network [OSTI]

    Uncorrected Proof Copy Finding Genes by Using Computational Tools 85 Job: Plant Functional Genomics/Rev.02.03 Uncorrected Proof Copy #12;Uncorrected Proof Copy Finding Genes by Using Computational Tools 87 Computational Tools 89 Job: Plant Functional Genomics--Grotewold Compositor: Nettype Chapter: Chapter 6 Date: 3

  7. Toehold Switches: De-Novo-Designed Regulators of Gene Expression

    E-Print Network [OSTI]

    Polz, Martin

    Resource Toehold Switches: De-Novo-Designed Regulators of Gene Expression Alexander A. Green,1. Here, we report a class of de-novo-designed prokaryotic riboregulators called toehold switches that activate gene expression in response to cognate RNAs with arbitrary sequences. Toehold switches provide

  8. Time-synchronized Clustering of Gene Expression Trajectories

    E-Print Network [OSTI]

    Müller, Hans-Georg

    Time-synchronized Clustering of Gene Expression Trajectories RONG TANG Division of Biostatistics, USA ABSTRACT Current clustering methods are routinely applied to gene expression time course data at different rates, successful clustering in this context requires dealing with varying time and shape patterns

  9. RESEARCH Open Access Transient receptor potential genes, smoking,

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    RESEARCH Open Access Transient receptor potential genes, smoking, occupational exposures and cough chemicals and may play an important role in the pathogenesis of cough. The aim was to study the influence of single nucleotide polymorphisms (SNPs) in TRP genes and irritant exposures on cough. Methods: Nocturnal

  10. Analysis of Antibiotic Resistant Genes in Aquacultural Bacteria

    E-Print Network [OSTI]

    Kane, Andrew S.

    1 Analysis of Antibiotic Resistant Genes in Aquacultural Bacteria JY Wang* YJ Geng RX Wang J Feng in the selection pressure, retained the resistant strains, spread among the same or different species of bacteria also increased #12;3 2.Potential Hazards of Resistant Bacteria · Resistant bacteria · Resistant gene

  11. Innovation and robustness in complex regulatory gene networks

    E-Print Network [OSTI]

    Wagner, Andreas

    Innovation and robustness in complex regulatory gene networks S. Ciliberti*, O. C. Martin* , and A involves countless evolutionary innovations, a steady stream of ingenuity that has been flowing for more such innovation. Here, we examine these principles for evolutionary innovation in gene expression patterns

  12. Non-random gene flow: an underappreciated force in evolution

    E-Print Network [OSTI]

    Bolnick, Daniel I.

    , adaptation to climate change, biological invasion, and speciation. Giv- en the possible ubiquity and impacts-random gene flow and to more fully incorporate its effects into theory. Rethinking the homogenizing effect of gene flow Theory suggests that evolutionary change depends on the action of a limited number

  13. Visualizing Conserved Gene Location across Microbe Chris D Shaw

    E-Print Network [OSTI]

    Shaw, Chris

    Visualizing Conserved Gene Location across Microbe Genomes Chris D Shaw School of Interactive Arts of microbes. The purpose of this visualizatiuon is to enable a biologist to examine the layout of genes help a biologist better confirm the structure and function of newly analyzed microbe DNA sequences. We

  14. Mining gene sets for measuring similarities CHRISTINE NARDINI1

    E-Print Network [OSTI]

    Nardini, Christine

    Mining gene sets for measuring similarities CHRISTINE NARDINI1 , DANIELE MASOTTI2 , SUNGROH YOON3 and data mining of these new, large types of data. The proliferation of devices able to process in paral of number of genes under different environmental conditions. Data mining algorithms demanded to the analysis

  15. GenePRIMP: A software quality control tool

    ScienceCinema (OSTI)

    Amrita Pati

    2010-09-01

    Amrita Pati of the DOE Joint Genome Institute's Genome Biology group describes the software tool GenePRIMP and how it fits into the quality control pipeline for microbial genomics. Further details regarding GenePRIMP appear in a paper published online May 2, 2010 in Nature Methods.

  16. GenePRIMP: A software quality control tool

    SciTech Connect (OSTI)

    Amrita Pati

    2010-05-05

    Amrita Pati of the DOE Joint Genome Institute's Genome Biology group describes the software tool GenePRIMP and how it fits into the quality control pipeline for microbial genomics. Further details regarding GenePRIMP appear in a paper published online May 2, 2010 in Nature Methods.

  17. Identification of Human Gene Core Promoters Michael Q. Zhang1

    E-Print Network [OSTI]

    supplement at http://www.genome.org.] As the Human Genome Project enters its large-scale sequencing phaseIdentification of Human Gene Core Promoters in Silico Michael Q. Zhang1 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 USA Identification of the 5 -end of human genes requires

  18. Kinetics of gene derepression by ERK signaling , Nria Samperb

    E-Print Network [OSTI]

    Shvartsman, Stanislav "Stas"

    Kinetics of gene derepression by ERK signaling Bomyi Lima , Núria Samperb , Hang Luc , Christine February 25, 2013) ERK controls gene expression in development, but mechanisms that link ERK activation to study transcriptional interpretation of ERK signaling during Dro- sophila embryogenesis, at a stage when

  19. Lung Disease in Pediatrics: is it all in the Genes?

    E-Print Network [OSTI]

    Lung Disease in Pediatrics: is it all in the Genes? Jay K. Kolls, M.D.Jay K. Kolls, M.D. Chair with CF do worse than other? #12;· Outcomes are better at CF centers · There is huge variation in lung with the same mutation do worse than others? · Modifier genes ­ lung disease ­ Tgfb1 ­ Irfd1 ­ neutrophil

  20. Diversity of gene expression in adenocarcinoma of the lung

    E-Print Network [OSTI]

    Botstein, David

    Diversity of gene expression in adenocarcinoma of the lung Mitchell E. Garber*, Olga G. Troyanskaya Contributed by David Botstein, September 21, 2001 The global gene expression profiles for 67 human lung tumors pathologic analysis. Four main histologic subtypes of lung cancer are regularly distinguished by tumor

  1. HumanMouse Gene Identification by Comparative Evidence Integration and

    E-Print Network [OSTI]

    Pavlovic, Vladimir

    The identification of genes in the human genome remains a challenge, as the actual predictions appear to disagree of genes in the human genome by using a reference, such as mouse genome. However, this comparative genome. In particular, it is not clear whether the mouse is at the correct evolutionary distance from

  2. Prediction of epigenetically regulated genes in breast cancer cell lines

    SciTech Connect (OSTI)

    Loss, Leandro A; Sadanandam, Anguraj; Durinck, Steffen; Nautiyal, Shivani; Flaucher, Diane; Carlton, Victoria EH; Moorhead, Martin; Lu, Yontao; Gray, Joe W; Faham, Malek; Spellman, Paul; Parvin, Bahram

    2010-05-04

    Methylation of CpG islands within the DNA promoter regions is one mechanism that leads to aberrant gene expression in cancer. In particular, the abnormal methylation of CpG islands may silence associated genes. Therefore, using high-throughput microarrays to measure CpG island methylation will lead to better understanding of tumor pathobiology and progression, while revealing potentially new biomarkers. We have examined a recently developed high-throughput technology for measuring genome-wide methylation patterns called mTACL. Here, we propose a computational pipeline for integrating gene expression and CpG island methylation profles to identify epigenetically regulated genes for a panel of 45 breast cancer cell lines, which is widely used in the Integrative Cancer Biology Program (ICBP). The pipeline (i) reduces the dimensionality of the methylation data, (ii) associates the reduced methylation data with gene expression data, and (iii) ranks methylation-expression associations according to their epigenetic regulation. Dimensionality reduction is performed in two steps: (i) methylation sites are grouped across the genome to identify regions of interest, and (ii) methylation profles are clustered within each region. Associations between the clustered methylation and the gene expression data sets generate candidate matches within a fxed neighborhood around each gene. Finally, the methylation-expression associations are ranked through a logistic regression, and their significance is quantified through permutation analysis. Our two-step dimensionality reduction compressed 90% of the original data, reducing 137,688 methylation sites to 14,505 clusters. Methylation-expression associations produced 18,312 correspondences, which were used to further analyze epigenetic regulation. Logistic regression was used to identify 58 genes from these correspondences that showed a statistically signifcant negative correlation between methylation profles and gene expression in the panel of breast cancer cell lines. Subnetwork enrichment of these genes has identifed 35 common regulators with 6 or more predicted markers. In addition to identifying epigenetically regulated genes, we show evidence of differentially expressed methylation patterns between the basal and luminal subtypes. Our results indicate that the proposed computational protocol is a viable platform for identifying epigenetically regulated genes. Our protocol has generated a list of predictors including COL1A2, TOP2A, TFF1, and VAV3, genes whose key roles in epigenetic regulation is documented in the literature. Subnetwork enrichment of these predicted markers further suggests that epigenetic regulation of individual genes occurs in a coordinated fashion and through common regulators.

  3. Extensive horizontal gene transfer, duplication, and loss of chlorophyll synthesis genes in the algae

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Hunsperger, Heather M.; Randhawa, Tejinder; Cattolico, Rose Ann

    2015-02-10

    Two non-homologous, isofunctional enzymes catalyze the penultimate step of chlorophyll a synthesis in oxygenic photosynthetic organisms such as cyanobacteria, eukaryotic algae and land plants: the light independent (LIPOR) and light-dependent (POR) protochlorophyllide oxidoreductases. Whereas the distribution of these enzymes in cyanobacteria and land plants is well understood, the presence, loss, duplication, and replacement of these genes have not been surveyed in the polyphyletic and remarkably diverse eukaryotic algal lineages.

  4. Extensive horizontal gene transfer, duplication, and loss of chlorophyll synthesis genes in the algae

    SciTech Connect (OSTI)

    Hunsperger, Heather M. [Univ. of Washington, Seattle, WA (United States); Randhawa, Tejinder [Univ. of Washington, Seattle, WA (United States); Cattolico, Rose Ann [Univ. of Washington, Seattle, WA (United States)

    2015-01-01

    Two non-homologous, isofunctional enzymes catalyze the penultimate step of chlorophyll a synthesis in oxygenic photosynthetic organisms such as cyanobacteria, eukaryotic algae and land plants: the light independent (LIPOR) and light-dependent (POR) protochlorophyllide oxidoreductases. Whereas the distribution of these enzymes in cyanobacteria and land plants is well understood, the presence, loss, duplication, and replacement of these genes have not been surveyed in the polyphyletic and remarkably diverse eukaryotic algal lineages.

  5. Review: Gene amplification--a cellular response to genotoxic stress

    SciTech Connect (OSTI)

    Lueke-Huhle, C. (Kernforschungszentrum Karlsruhe, Institut fuer Genetik und Toxikologie (West Germany))

    1989-10-01

    Recent years of cancer research have defined the role of key regulatory genes in oncogenesis. Oncogenes and suppressor genes are affected in the process of carcinogenesis either by mutations within the coding region, promoter mutations, or gene amplification. This review describes the authors studies on gene amplification in mammalian cells, with emphasis on the initiating events induced by carcinogenic chemicals and various types of radiation. The influence of genomic instability, cell dedifferentiation, and the malignant potential of a cell on their capacity to amplify genes is demonstrated by molecular biologic and cytogenetic studies on human and rodent cells. Cells that contain amplified DNA are at risk for chromosomal aberrations, sister chromatid exchanges, and rearrangements. Surviving cells show such cancer-prone genetic consequences. 52 references.

  6. Domestication of the neotropical tree Chrysophyllum cainito from a geographically limited yet genetically diverse gene pool in Panama

    E-Print Network [OSTI]

    Parker, Ingrid M.

    2014-01-01

    genetically diverse gene pool in Panama Jennifer J. Petersenincorporating a diverse gene pool. These results refute theof human influences on gene pools through selection and

  7. Genomic analyses of bacterial porin-cytochrome gene clusters

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Shi, Liang; Fredrickson, James K.; Zachara, John M.

    2014-11-26

    In this study, the porin-cytochrome (Pcc) protein complex is responsible for trans-outer membrane electron transfer during extracellular reduction of Fe(III) by the dissimilatory metal-reducing bacterium Geobacter sulfurreducens PCA. The identified and characterized Pcc complex of G. sulfurreducens PCA consists of a porin-like outer-membrane protein, a periplasmic 8-heme c type cytochrome (c-Cyt) and an outer-membrane 12-heme c-Cyt, and the genes encoding the Pcc proteins are clustered in the same regions of genome (i.e., the pcc gene clusters) of G. sulfurreducens PCA. A survey of additionally microbial genomes has identified the pcc gene clusters in all sequenced Geobacter spp. and other bacteriamore »from six different phyla, including Anaeromyxobacter dehalogenans 2CP-1, A. dehalogenans 2CP-C, Anaeromyxobacter sp. K, Candidatus Kuenenia stuttgartiensis, Denitrovibrio acetiphilus DSM 12809, Desulfurispirillum indicum S5, Desulfurivibrio alkaliphilus AHT2, Desulfurobacterium thermolithotrophum DSM 11699, Desulfuromonas acetoxidans DSM 684, Ignavibacterium album JCM 16511, and Thermovibrio ammonificans HB-1. The numbers of genes in the pcc gene clusters vary, ranging from two to nine. Similar to the metal-reducing (Mtr) gene clusters of other Fe(III)-reducing bacteria, such as Shewanella spp., additional genes that encode putative c-Cyts with predicted cellular localizations at the cytoplasmic membrane, periplasm and outer membrane often associate with the pcc gene clusters. This suggests that the Pcc-associated c-Cyts may be part of the pathways for extracellular electron transfer reactions. The presence of pcc gene clusters in the microorganisms that do not reduce solid-phase Fe(III) and Mn(IV) oxides, such as D. alkaliphilus AHT2 and I. album JCM 16511, also suggests that some of the pcc gene clusters may be involved in extracellular electron transfer reactions with the substrates other than Fe(III) and Mn(IV) oxides.« less

  8. Identification of DNA marker for root-knot nematode resistance gene and characterization of disease resistance gene candidates in cotton 

    E-Print Network [OSTI]

    He, Limei

    2000-01-01

    , bacteria, viruses and nematodes, in cotton, resistance gene candidates were cloned by PCR using a pair of degenerate primers designed from the conserved sequences of disease resistance genes cloned from a variety of plant taxa. From a 96-clone sample, 23...

  9. "A force illegible": A study of Emily Dickinson's view of God 

    E-Print Network [OSTI]

    Thompson, Margaret Henderson

    1970-01-01

    , on nature, death and immortality, he shows something of her religious 2Ann Arbor, 1957. Originally published in New York in 1938. Cambridge, Massachusetts, 1955. views, but this is not his main empha is. The la chapter, "The Colossal Substance... partner to the Creator, although he is iotally dependent on God. His interpretation is that, for Emily, God is not yet perfected and may never be According to this view, when God achieves fulf illmeni it wi'1 be partially due to man's efforts, too...

  10. Experiments at Scale with In-Situ Visualization Using ParaView/Catalyst in RAGE

    SciTech Connect (OSTI)

    Kares, Robert John

    2014-10-31

    In this paper I describe some numerical experiments performed using the ParaView/Catalyst in-situ visualization infrastructure deployed in the Los Alamos RAGE radiation-hydrodynamics code to produce images from a running large scale 3D ICF simulation on the Cielo supercomputer at Los Alamos. The detailed procedures for the creation of the visualizations using ParaView/Catalyst are discussed and several images sequences from the ICF simulation problem produced with the in-situ method are presented. My impressions and conclusions concerning the use of the in-situ visualization method in RAGE are discussed.

  11. Under-Sodium Viewing: A Review of Ultrasonic Imaging Technology for Liquid Metal Fast Reactors

    SciTech Connect (OSTI)

    Griffin, Jeffrey W.; Peters, Timothy J.; Posakony, Gerald J.; Chien, Hual-Te; Bond, Leonard J.; Denslow, Kayte M.; Sheen, Shuh-Haw; Raptis, Paul

    2009-03-27

    This current report is a summary of information obtained in the "Information Capture" task of the U.S. DOE-funded "Under Sodium Viewing (USV) Project." The goal of the multi-year USV project is to design, build, and demonstrate a state-of-the-art prototype ultrasonic viewing system tailored for periodic reactor core in-service monitoring and maintenance inspections. The study seeks to optimize system parameters, improve performance, and re-establish this key technology area which will be required to support any new U.S. liquid-metal cooled fast reactors.

  12. Television Viewing, Walking Speed and Grip Strength in a Prospective Cohort Study

    E-Print Network [OSTI]

    Keevil, Victoria L.; Wijndaele, Katrien; Luben, Robert; Sayer, Avan A.; Wareham, Nicholas J.; Khaw, Kay-Tee

    2014-07-18

    , strong and consistent associations between grip strength and TV viewing time were not observed. Isometric muscle strength encapsulates only one aspect of muscle func- tion, and low performance may be present without low strength or vice versa, a concept... for age, physical activity, anthropome- try, wealth, comorbidity, smoking, and alcohol intake and combined if no sex–TV viewing time interactions were identified. Results: Men and women who watched the least TV at the 2HC or 3HC walked at a faster usual...

  13. Modulation of Gene Expression by Polymer Nanocapsule Delivery of DNA Cassettes Encoding Small RNAs.

    E-Print Network [OSTI]

    Yan, M; Wen, J; Liang, M; Lu, Y; Kamata, M; Chen, IS

    2015-01-01

    of Gene Expression by Polymer Nanocapsule S5 Fig. Stabilityof Gene Expression by Polymer Nanocapsule Rao D, Vorhies J,of Gene Expression by Polymer Nanocapsule Delivery of DNA

  14. B and C class MADS-box genes and the developmental genetics of maize flower development

    E-Print Network [OSTI]

    Whipple, Clinton J.

    2006-01-01

    diversification of the two C-Class MADS box genes OSMADS32004). Conservation of B-class floral homeotic gene function2004). Conservation of B-class floral homeotic gene function

  15. A CRTC2 Repressor Role Regulates DNA Damage Response Genes in Germinal Center B-cells

    E-Print Network [OSTI]

    Schontzler, Olivia Tersa

    2012-01-01

    as DNA damage response (DDR) genes throughout this proposal.binding to and repression of DDR genes. Secondly, repressorcontextual repressor role on DDR genes as part of an ATM

  16. The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus purpuratus genome

    E-Print Network [OSTI]

    The chemical defensome: Environmental sensing and response genes in the Strongylocentrotus September 2006 Abstract Metazoan genomes contain large numbers of genes that participate in responses families thought to protect against chemical stressors; these genes collectively comprise the `chemical

  17. Application of Logic Synthesis Toward the Inference and Control of Gene Regulatory Networks 

    E-Print Network [OSTI]

    Lin, Pey Chang K

    2013-06-27

    effort of modeling cell behavior, inferring biological networks, and controlling genetic diseases. Genes interact with other genes in a Gene Regulatory Network (GRN) and can be modeled as a Boolean Network (BN) or equivalently as a Finite State Machine...

  18. Modeling Gene Regulatory Networks from Time Series Data using Particle Filtering 

    E-Print Network [OSTI]

    Noor, Amina

    2012-10-19

    This thesis considers the problem of learning the structure of gene regulatory networks using gene expression time series data. A more realistic scenario where the state space model representing a gene network evolves nonlinearly is considered while...

  19. Discovery of Candidate Genes for Stallion Fertility from the Horse Y Chromosome 

    E-Print Network [OSTI]

    Paria, Nandina

    2012-02-14

    of selected body tissues showed that some ECAY genes are expressed exclusively in testes while others show ubiquitous or intermediate expression. Quantitative Real-Time PCR using primers for 9 testis-specific multicopy genes revealed 5 genes with statistically...

  20. Multiple gene genealogies and microsatellite markers reflect relationships between morphotypes of Sphaeropsis sapinea

    E-Print Network [OSTI]

    Multiple gene genealogies and microsatellite markers reflect relationships between morphotypes between isolates representing different S. sapinea morphotypes, using multiple gene genealogies inferred from partial sequences of six protein-coding genes and six microsatellite loci. Genealogies generated

  1. Polymorphic nuclear gene sequences indicate a novel genome donor in the polyploid genus Thinopyrum

    E-Print Network [OSTI]

    Pappu, Hanu R.

    of the granule-bound starch synthase (GBSSI) gene and intron III of the beta-amylase gene (Bmy1) were isolated

  2. View-based dynamic object recognition based on human perception Heinrich H. Bulthoff, Christian Wallraven, Arnulf Graf

    E-Print Network [OSTI]

    of a particular object or ob- ject category. For example, frontal-, side- or top-views of a helicopter are very

  3. Bunker View: Limited-range head-motion-parallax visualization for complex data sets

    E-Print Network [OSTI]

    Pollefeys, Marc

    of head-motion-parallax. In particular, the frame rates are often too low for convincing headBunker View: Limited-range head-motion-parallax visualization for complex data sets Andrei State Chapel Hill, North Carolina, 27514 ABSTRACT This work presents a head-motion-parallax visualization

  4. Reduced form electricity spot price modeling with a view towards spike risk

    E-Print Network [OSTI]

    Gerkmann, Ralf

    Reduced form electricity spot price modeling with a view towards spike risk Prof. Dr. Meyer. Februar 2010, 16:15 Uhr Seminarraum, Ludwigstraße 33 I The recent deregulation of electricity markets has led to the creation of energy exchanges, where the electricity is freely traded. We study the most

  5. Machine Ethics and Human Ethics: A Critical View Francesco Amigoni and Viola Schiaffonati

    E-Print Network [OSTI]

    Amigoni, Francesco

    Machine Ethics and Human Ethics: A Critical View Francesco Amigoni and Viola Schiaffonati@elet.polimi.it Abstract The rapid changes in the relationship between humans and machines evidence a progressive delegation of some human activities to machines. Among those, there are not only physical activities but also

  6. New Hampshire Resident Views on the Use, Availability, and Need for Public Transportation

    E-Print Network [OSTI]

    New Hampshire, University of

    New Hampshire Resident Views on the Use, Availability, and Need for Public Transportation Full project of the University of New Hampshire's Institute on Disability/UCED and the Community Action Program Belknap-Merrimack Counties, Inc. to document New Hampshire residents' perceptions about their access

  7. Maotai 3.0: Automatic Detection of View Access in VOPP K. Leung and Z. Huang

    E-Print Network [OSTI]

    Huang, Zhiyi

    ) model. VOPP is a shared-memory-based, data-centric model that uses "views" to bundle mutual exclusion is designed to eliminate data race [4, 5]. VOPP is a data-centric model, where shared data objects other data-centric models [8], VOPP bundles mutual exclusion and data access together and therefore

  8. SUPERVISED AND UNSUPERVISED MRF BASED 3D SCENE CLASSIFICATION IN MULTIPLE VIEW

    E-Print Network [OSTI]

    SUPERVISED AND UNSUPERVISED MRF BASED 3D SCENE CLASSIFICATION IN MULTIPLE VIEW AIRBORNE OBLIQUE Classification in 3D object space Basic idea Supervised approach Unsupervised approah Experiments: data and results Discussion CONTENTS #12; State-of-the-Art digital camera hardware and processing stimuate

  9. Reflective responsibility for risk: a critical view of software and information systems development risk

    E-Print Network [OSTI]

    De Montfort University

    evaluation of future states because the future is by definition unknown. Risks as known uncertaintiesReflective responsibility for risk: a critical view of software and information systems development risk management Bernd Carsten Stahl Faculty of Computer Science and Engineering, Centre for Computing

  10. Linking ArcView 3.0TM and XGobi: Insight Behind the Front End

    E-Print Network [OSTI]

    Symanzik, Jürgen

    of the implementation of a bidirectional link between the Geographic Information System GIS ArcView 3.0TM; Geographic information system; Imple- mentation issues; Spatial cumulative distribution function; Spatial statistics; Spatially lagged scatterplot; Variogram cloud plot. 1 Introduction Geographic Information Systems

  11. Linking ArcView 3.0TM and XGobi: Insight Behind the Front End

    E-Print Network [OSTI]

    Symanzik, Jürgen

    of a bidirectional link between the Geographic Information System (GIS) ArcView 3.0TM and the interactive dynamic Information Systems (GISs) are used extensively for examining spa- tial data but, traditionally, they have few tools necessary for displaying geographic information. The lack of ex- ploratory tools in a GIS

  12. Cross-sectional Views of 90/90 Pipe Without/With a Weld

    E-Print Network [OSTI]

    McDonald, Kirk

    Cross-sectional Views of 90/90 Pipe Without/With a Weld Yan 9-20-2012 #12;Outlines · Define the Locations of the Profiles · Pipe without A Weld (#Grid = 0.8×106) ­ Display in Tecplot: Figs.(a) ­ Display in FLUENT: Figs.(b) · Contours of Turbulence Intensity in Tecplot ­ Pipe with A Weld (#Grid = 1

  13. Diurnal temperature range over the United States: A satellite view Donglian Sun,1

    E-Print Network [OSTI]

    Sun, Donglian

    Diurnal temperature range over the United States: A satellite view Donglian Sun,1 Rachel T. Pinker; published 4 March 2006. [1] Diurnal temperature range (DTR) is an important climate change index. Information on this parameter comes primarily from sparse and unevenly distributed observations of shelter air

  14. God and the Human Experience A physicist's case for a theistic world view

    E-Print Network [OSTI]

    Gea-Banacloche, Julio

    God and the Human Experience A physicist's case for a theistic world view Julio Gea-Banacloche 1, starting from the basic facts about the human experience of existence. For convenience (but also, when they, in turn, experience the need to look beyond the simple conception of God that saw them

  15. God and the human experience A physicist's case for a theistic world view

    E-Print Network [OSTI]

    Gea-Banacloche, Julio

    God and the human experience A physicist's case for a theistic world view Julio Gea-Banacloche 1 and--possibly--relate to that reality, by considering the various aspects of our (human beings') experience of existence. For convenience (but also with an ulterior theological purpose in mind

  16. VISSOFT'07 Submission Kagdi, Maletic Onion Graphs for Focus+Context Views of UML Class Diagrams

    E-Print Network [OSTI]

    Maletic, Jonathan I.

    VISSOFT'07 Submission Kagdi, Maletic Onion Graphs for Focus+Context Views of UML Class Diagrams+context technique for visualizing large UML class models. The focus area, which can be manually or automatically source project. 1. Introduction Developers find UML class models1 useful for designing systems along

  17. A molecular thermodynamic view of DNAdrug interactions: a case study of 25 minor-groove binders

    E-Print Network [OSTI]

    Jayaram, Bhyravabotla

    A molecular thermodynamic view of DNA­drug interactions: a case study of 25 minor-groove binders-groove recognition by small molecules via a computational study on 25 DNA­drug complexes. The studies are configured of this study. While highlighting the favorable role of packing, shape complementarity, and van der Waals

  18. CLAS12 Software Workshop Broad view of the state-of-the-art in

    E-Print Network [OSTI]

    Gilfoyle, Jerry

    CLAS12 Software Workshop Goals: Broad view of the state-of-the-art in offline analysis. Status of the CLAS12 software program. Opportunities for users to join that program. Tutorials on CLAS12 software://conferences.jlab.org/CLAS12Software/index.html CLAS12 Software Workshop ­ p. 1/ #12;CLAS12 Software Workshop Program (Morning

  19. View Based Integration of Heterogeneous Web Service Registries--the Case of VISR

    E-Print Network [OSTI]

    Dustdar, Schahram

    View Based Integration of Heterogeneous Web Service Registries--the Case of VISR Schahram Dustdar efforts in the Web service area, several dif- ferent incompatible Web service registry implementations distributed Web service registries. In addition, the creation of specialized Web service registries leads

  20. Critical issues and current views on teaching basic circuits and systems in electrical engineering education

    E-Print Network [OSTI]

    education Joos Vandewalle Department of Electrical Engineering (ESAT) Katholieke Universiteit Leuven B-3001, its impact in the electrical engineering education and in order to increase the intrinsic interestCritical issues and current views on teaching basic circuits and systems in electrical engineering

  1. NEWS & VIEWS nature physics | VOL 2 | JUNE 2006 | www.nature.com/naturephysics 367

    E-Print Network [OSTI]

    Loss, Daniel

    solar cycle to be at its weakest in almost a century. A recent prediction to the contrary could turnNEWS & VIEWS nature physics | VOL 2 | JUNE 2006 | www.nature.com/naturephysics 367 SOLAR PHYSICS Back to the next solar cycle Many solar physicists expect the peak sunspot activity during the next

  2. Managing United States Public Lands in Response to Climate Change: A View From the Ground Up

    E-Print Network [OSTI]

    Neff, Jason

    Managing United States Public Lands in Response to Climate Change: A View From the Ground Up and resource managers, it is not yet clear how issues related to climate change will be incorporated into on in which climate change or carbon management may intersect other use goals: forests, biofuels, and grazing

  3. TrafficView: Traffic Data Dissemination using Car-to-Car Communication

    E-Print Network [OSTI]

    Iftode, Liviu

    TrafficView: Traffic Data Dissemination using Car-to-Car Communication Tamer Nadeema, Sasan high- tech devices are integrated, and a common platform for inter-vehicle communication is necessary platform for inter-vehicle communication is necessary to realize an intelligent transportation system

  4. 142 NATURE GEOSCIENCE | VOL 4 | MARCH 2011 | www.nature.com/naturegeoscience news & views

    E-Print Network [OSTI]

    that nature took care of the spill, at least as far as gas is concerned. Nevertheless, the studies should humans do -- be it oil spills or greenhouse gas emissions -- the environmental and economic costs142 NATURE GEOSCIENCE | VOL 4 | MARCH 2011 | www.nature.com/naturegeoscience news & views much

  5. View from the Cloud Editor: George Pallis gpallis@cs.ucy.ac.cy

    E-Print Network [OSTI]

    's susceptible to security threats. Security concerns also arise because public clouds are designed under cloud would deliver some of the same long-recognized security benefits as has open source softwareView from the Cloud Editor: George Pallis · gpallis@cs.ucy.ac.cy 2 Published by the IEEE Computer

  6. IEEE 1451 standard and wireless sensor networks: An over view of fault tolerant algorithms

    E-Print Network [OSTI]

    227 IEEE 1451 standard and wireless sensor networks: An over view of fault tolerant algorithms Shubha Kher Senior member IEEE, Jinran Chen and Arun K Somani, Fellow IEEE Dependable Computing Lab, Iowa state University, Ames, IA 50011 tshubhajrchen,arun @,iastate. edu Abstract The IEEE 1451 standards

  7. Co-sponsored by ME and CEMS Departments The Outlook for Energy: A View

    E-Print Network [OSTI]

    Fisher, Frank

    ) Darnell Manager, Research and Development Support Services ExxonMobil Research & Engineering Company ABSTRACT The Outlook for Energy is ExxonMobil's long-term view of our shared energy future. We developed to help guide our own strategies and investments. Over the next five years, ExxonMobil expects to invest

  8. Co-sponsored by CEMS and ME Departments The Outlook for Energy: A View

    E-Print Network [OSTI]

    Fisher, Frank

    Section Head, Emerging Energy Science Corporate Strategic Research ExxonMobil Research & Engineering Company ABSTRACT The Outlook for Energy is ExxonMobil's long-term view of our shared energy future. We to help guide our own strategies and investments. Over the next five years, ExxonMobil expects to invest

  9. Co-sponsored by CEMS and ME Departments The Outlook for Energy: A View

    E-Print Network [OSTI]

    Fisher, Frank

    ) Darnell Manager, Research and Development Support Services ExxonMobil Research & Engineering Company ABSTRACT The Outlook for Energy is ExxonMobil's long-term view of our shared energy future. We develop to help guide our own strategies and investments. Over the next five years, ExxonMobil expects to invest

  10. 98 NATURE CLIMATE CHANGE | VOL 1 | MAY 2011 | www.nature.com/natureclimatechange news & views

    E-Print Network [OSTI]

    Lockwood, Mike

    98 NATURE CLIMATE CHANGE | VOL 1 | MAY 2011 | www.nature.com/natureclimatechange news & views that changes in solar output must be responsible for large changes in climate. This thinking neglects a key the effect that centennial-scale changes in solar activity have on climate4 . Initially, our best estimates

  11. Early View (EV): 1-EV Nice weather for bettongs: using weather events, not climate

    E-Print Network [OSTI]

    Turner, Monica G.

    distribution using temporally matched observations of the species with weather data (includ- ing extremeEarly View (EV): 1-EV Nice weather for bettongs: using weather events, not climate means applications of species distribution models (SDM) are typically static, in that they are based on correlations

  12. Network Utilization: the Flow View Avinatan Hassidim, Danny Raz, Michal Segalov Ariel Shaqed

    E-Print Network [OSTI]

    Cortes, Corinna

    Network Utilization: the Flow View Avinatan Hassidim, Danny Raz, Michal Segalov Ariel Shaqed Google a substantial investment. Therefore, there is an economical drive to increase the utilization of network, the utilization of network components has a direct impact on the performance of the network and its resilience

  13. View Operations on Objects with Roles for a Statically Typed Database Language

    E-Print Network [OSTI]

    Ghelli, Giorgio

    to the evolution of application requirements. It is widely recognized that long lasting, evolving databases need; |views mechanisms to adapt the database schema to the changing needs of users; |schema evolution,tosupport the rst twoaspects of database evolution: Author's address: Dipartimento di Informatica, Universit#12;a di

  14. Multiple Exciton Coherence Sizes in Photosynthetic Antenna Complexes viewed by Pump-Probe Spectroscopy

    E-Print Network [OSTI]

    Mukamel, Shaul

    Multiple Exciton Coherence Sizes in Photosynthetic Antenna Complexes viewed by Pump, 1996X The pump-probe signal from the light-harvesting antenna LH2 of purple bacteria is analyzed using absorption,4,5 pump-probe,11-16 and three pulse echoes.8,17 These measurements show ultrafast energy transfer

  15. VIEWS ON U.S. WATER RESEARCH AND TECHNOLOGY TRANSFER PROGRAMS

    E-Print Network [OSTI]

    District of Columbia, University of the

    #12;VIEWS ON U.S. WATER RESEARCH AND TECHNOLOGY TRANSFER PROGRAMS By MAMADOU H. WATT, Director . . . . . . . . . . 18 5. Technology Transfer and Information Dissemination . . . . 20 5.1 Definition and Purpose. . . . . . . . . . . . . . . 20 5.2 The Process of Technology Transfer. . . . . . . . . 21 5.3 Products of Technology Transfer

  16. NEWS & VIEWS nature physics | VOL 2 | JULY 2006 | www.nature.com/naturephysics 445

    E-Print Network [OSTI]

    Loss, Daniel

    . In tokamak-based fusion plasmas, reconnection occurs as a result of plasma instabilities and hampers magnetic confinement. It influences the dayside dynamics of the Earth's magnetosphere and the magnetic substormsNEWS & VIEWS nature physics | VOL 2 | JULY 2006 | www.nature.com/naturephysics 445 MAGNETIC

  17. Pathways for protein folding: is a "new view" needed? Vijay S Pande1

    E-Print Network [OSTI]

    Croquette, Vincent

    Pathways for protein folding: is a "new view" needed? Vijay S Pande1 , Alexander Yu Grosberg2 energy MG Molten globule Introduction How do proteins fold? While the thirty five years since Anfinsen has demonstrated the complexity of protein folding, the search continues for the general principles

  18. A Bayesian view on motor control and planning Marc Toussaint and Christian Goerick

    E-Print Network [OSTI]

    Toussaint, Marc

    A Bayesian view on motor control and planning Marc Toussaint and Christian Goerick Abstract. iterative Linear Quadratic Gaussian (iLQG)). Marc Toussaint Technical University Berlin, Franklinstr. 28-Legien-Strasse 30, 63073 Offenbach/Main, Germany, e- mail: christian.goerick@honda-ri.de 1 #12;2 Marc Toussaint

  19. Users' View on Context-Sensitive Car Advertisements Florian Alt, Christoph Evers, Albrecht Schmidt

    E-Print Network [OSTI]

    Users' View on Context-Sensitive Car Advertisements Florian Alt, Christoph Evers, Albrecht Schmidt.alt, albrecht.schmidt}@uni-due.de christoph.evers@stud.uni-due.de Abstract. Cars are ubiquitous and offer large static, with the exception of car-mounted displays that offer dy- namic content. With new display

  20. Sustained and Transient Modulation of Performance Induced by Emotional Picture Viewing

    E-Print Network [OSTI]

    Pessoa, Luiz

    Sustained and Transient Modulation of Performance Induced by Emotional Picture Viewing Mirtes-irrelevant emotional pictures affects the performance of a subsequent nonemotional visual detection task. Subjects performed target-detection trials following the offset of individual unpleasant, pleasant, and neutral

  1. April 22, 2010 Coronal hole boundaries evolution at small scales: II. XRT view

    E-Print Network [OSTI]

    April 22, 2010 Coronal hole boundaries evolution at small scales: II. XRT view Can small-scale outflows at CHBs be a source of the slow solar wind? S. Subramanian, M. S. Madjarska and J. G. Doyle Armagh to further explore the small-scale evolution of coronal hole boundaries using X-ray high-resolution and high

  2. University of Arkansas Libraries Prepare your Computer to View the New Crystal Reports

    E-Print Network [OSTI]

    Capogna, Luca

    University of Arkansas Libraries Prepare your Computer to View the New Crystal Reports 1. Go to My windows. 27. Now you should create a folder for your report(s) wherever is convenient for you (for example, folder. Name the new folder "My Reports" or "My Web Reports"--again, whatever is convenient. 28. In your

  3. News and Views Conference Report: Paleoanthropology of the Mani Peninsula (Greece)

    E-Print Network [OSTI]

    Delson, Eric

    News and Views Conference Report: Paleoanthropology of the Mani Peninsula (Greece) K. Harvati & E in Athens and Areopolis, Greece, on the Paleoanthropol- ogy of the Mani Peninsula. The conference publication outside Greece is a short article on forensic implications of damage to one cranium (Coutselinis

  4. DOE Zero Energy Ready Home Case Study: Clifton View Homes, Coupeville, Washington

    SciTech Connect (OSTI)

    none,

    2013-09-01

    Ted Clifton, founder of Clifton View Homes, achieved an impressive Home Energy Rating System (HERS) score of 34 (without solar panels) on a two-story home completed in July 2011 that also earned him his first Challenge Home certification from the U.S. Department of Energy (DOE). This home also garnered a 2013 Housing Innovation Award in the "systems builder" category.

  5. The Arab States and the Refugee Issue: A Retrospective View Jalal Al Husseini

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    The Arab States and the Refugee Issue: A Retrospective View Jalal Al Husseini I. Introduction This chapter aims at defining the Arab states' position with regard to the Palestinian refugee question and the legal status of the refugees in each of these states.2 However, little attention has been paid

  6. Internet use and non-use: views of older users ANNE MORRIS*, JOY GOODMAN

    E-Print Network [OSTI]

    Goodman, Joy

    1 Internet use and non-use: views of older users ANNE MORRIS*, JOY GOODMAN + AND HELENA BRADING: older people elderly Internet digital divide technology Abstract: This paper reports the results of two connected surveys of computer and Internet use among the older population in the UK. 120 questionnaires

  7. 184 NATURE CLIMATE CHANGE | VOL 3 | MARCH 2013 | www.nature.com/natureclimatechange news & views

    E-Print Network [OSTI]

    Thomas, David D.

    184 NATURE CLIMATE CHANGE | VOL 3 | MARCH 2013 | www.nature.com/natureclimatechange news & views better job of considering the full range of biodiversity in natural populations of marine species than we@usc.edu References 1. Schaum, E., Rost, B., Millar, A. J. & Collins, S. Nature Clim. Change 3, 298­302 (2013). 2

  8. NATURE CLIMATE CHANGE | VOL 1 | APRIL 2011 | www.nature.com/natureclimatechange 29 news & views

    E-Print Network [OSTI]

    Polvani, Lorenzo M.

    NATURE CLIMATE CHANGE | VOL 1 | APRIL 2011 | www.nature.com/natureclimatechange 29 news & views of experiments in which they added inorganic forms of nitrogen, amino acids and peptides to soils and plants from acquires nitrogen in the field. Their results provide compelling evidence that the species is able to take

  9. Cauchy transforms of measures viewed as some functionals of Fourier transforms #

    E-Print Network [OSTI]

    Jurek, Zbigniew J.

    Cauchy transforms of measures viewed as some functionals of Fourier transforms # Zbigniew J. Jurek Urbanik ABSTRACT. The Cauchy transform of a positive measure plays an impor­ tant role in complex analysis and more recently in so­called free probability. We show here that the Cauchy transform restricted

  10. Cauchy transforms of measures viewed as some functionals of Fourier transforms

    E-Print Network [OSTI]

    Jurek, Zbigniew J.

    Cauchy transforms of measures viewed as some functionals of Fourier transforms Zbigniew J. Jurek Urbanik ABSTRACT. The Cauchy transform of a positive measure plays an impor- tant role in complex analysis and more recently in so-called free probability. We show here that the Cauchy transform restricted

  11. NATURE CHEMISTRY | VOL 3 | SEPTEMBER 2011 | www.nature.com/naturechemistry 659 news & views

    E-Print Network [OSTI]

    Sia, Samuel K.

    ion (uranium). The use of chemistry for improving sensors is particularly inspired. Current workNATURE CHEMISTRY | VOL 3 | SEPTEMBER 2011 | www.nature.com/naturechemistry 659 news & views D if analogous enzymes are available for the analyte of interest. Writing in Nature Chemistry, Yi Lu and Yu Xiang

  12. View Dependence of 3D Recovery from Folded Pictures and Warped 3D Faces

    E-Print Network [OSTI]

    Cavanagh, Patrick

    View Dependence of 3D Recovery from Folded Pictures and Warped 3D Faces Patrick Cavanagh Department vertical lines through the nose and the eyes. When this folded picture is tilted back and forth, the same is true, over a more restricted range of angles, as we move in front of a picture of an object

  13. Early View (EV): 1-EV Historical climate-change influences modularity and nestedness of

    E-Print Network [OSTI]

    Chittka, Lars

    , and then test these against empirical data. We propose that historical climate-change may have left imprintsEarly View (EV): 1-EV Historical climate-change influences modularity and nestedness of pollination. Wang, and C. Rahbek, Center for Macroecology, Evolution and Climate, Univ. of Copenhagen

  14. National Aeronautics and Space Administration GoddardViewVolume 5 Issue 8

    E-Print Network [OSTI]

    Christian, Eric

    ­ 9 Honey Bees Turned Data Collectors Help Scientists Understand Climate Change ­ 10 Goddard Family Discover will host NASA's climate simulations for the Intergovern- mental Panel on Climate Change. PhotoNational Aeronautics and Space Administration GoddardViewVolume 5 Issue 8 Climate Simulation

  15. nature methods | VOL.11 NO.2 | FEBRUARY 2014 | 117 Points of View

    E-Print Network [OSTI]

    Cai, Long

    encoding and preferred over the angle-based strategy used in pie charts (Fig. 1a). Often the counts that we bar chart is equivalent to multiple pie charts, yet a grouped bar chart affords more accurate readingsnature methods | VOL.11 NO.2 | FEBRUARY 2014 | 117 this month Points of View Bar charts and box

  16. nature physics | VOL 6 | DECEMBER 2010 | www.nature.com/naturephysics 939 news & views

    E-Print Network [OSTI]

    Loss, Daniel

    the transition from what we now call `classical' to `modern' physics. With the new concepts and fields of studynature physics | VOL 6 | DECEMBER 2010 | www.nature.com/naturephysics 939 news & views coherent). For physics, the first half of the twentieth century was a time of profound transformation, bringing about

  17. Materialized views for P2P XML warehousing Ioana Manolescu Spyros Zoupanos

    E-Print Network [OSTI]

    Manolescu, Ioana

    , the European defense company, and CEA, the French nuclear energy producer. The project focuses on giving in the number of views, and describe rewriting algorithms. Our approach is validated by experiments these companies efficient tools for gathering, enriching and exploiting (e.g. by semantic and linguistic analysis

  18. 798 | VOL.6 NO.11 | NOVember 2009 | nature methods news and views

    E-Print Network [OSTI]

    Cai, Long

    798 | VOL.6 NO.11 | NOVember 2009 | nature methods news and views approaches designed to identify. Ear, P.H. & Michnick, S.W. Nat. Methods 6, 813­ 816 (2009). 3. Dixon, S.J., Costanzo, M., Baryshnikova crystal structure. This approach has been extremely powerful and the two high- lighted studies1,2 expand

  19. A CSP View on UMLRT structure diagrams Clemens Fischer, ErnstRudiger Olderog and Heike Wehrheim

    E-Print Network [OSTI]

    Habel, Annegret

    A CSP View on UML­RT structure diagrams Clemens Fischer, Ernst­R¨udiger Olderog and Heike Wehrheim UML­RT structure diagrams together with the formal method CSP­OZ combining CSP and Object­Z. While CSP­OZ is used for specifying the system components themselves (by CSP­OZ classes), UML­RT diagrams provide

  20. Learnability of Interactive Coordinated-View Visualizations Sujatha Krishnamoorthy, Christopher North

    E-Print Network [OSTI]

    features which are desirable for novice-friendliness: Task based organization of coordinated views charts and bar graphs and weather information on maps as seen in weather news broadcasts. · General website would be familiar with WIMP interfaces. An informal survey revealed that bar-charts and pie-charts

  1. INTRODUCTION The caudal fin of fishes has often been viewed by engineers as a

    E-Print Network [OSTI]

    Flammang, Brooke

    56 INTRODUCTION The caudal fin of fishes has often been viewed by engineers as a relatively simple propulsive surface that is flapped by fish in a two- dimensional motion that is an extension; Anton et al., 2009). However, in many fishes the caudal fin is used not exclusively for thrust

  2. Sleep Deprivation Impairs Object-Selective Attention: A View from the Ventral Visual Cortex

    E-Print Network [OSTI]

    Pennsylvania, University of

    attention task. During this task, pictures of houses or faces were randomly interleaved among scrambled images. Across different blocks, volunteers responded to house but not face pictures, face but not house pictures, or passively viewed pictures without responding. The appearance of task-relevant pictures

  3. Hierarchical Volumetric Multi-view Stereo Reconstruction of Manifold Surfaces based on Dual Graph Embedding

    E-Print Network [OSTI]

    Kazhdan, Michael

    Hierarchical Volumetric Multi-view Stereo Reconstruction of Manifold Surfaces based on Dual Graph://www.rwth-graphics.de Abstract This paper presents a new volumetric stereo algorithm to reconstruct the 3D shape of an arbitrary into the volumetric grid, which establishes a well defined relationship between the integrated photo

  4. New Dimensions of Visual Landscape Assessment Wildlands Management for Wildlife Viewing1

    E-Print Network [OSTI]

    Standiford, Richard B.

    preservation and other activities associated with traditional game management. Fortunately, much of the knowledge and techniques developed for game #12;management can be transferred to considerations of wildlifeNew Dimensions of Visual Landscape Assessment Wildlands Management for Wildlife Viewing1 Tamsie

  5. NATURE NANOTECHNOLOGY | VOL 9 | DECEMBER 2014 | www.nature.com/naturenanotechnology 965 news & views

    E-Print Network [OSTI]

    Aeschlimann, Martin

    for ever-smaller spintronic devices that are both energy efficient and non-volatile. One promising approach & views MOLECULAR SPINTRONICS Topology communicates A magnetic skyrmion lattice can mediate transport-sensitive scanning tunnelling microscopy: a technique in which the local magnetization of a sample is measured using

  6. ---Search Finance Home Yahoo! Help Welcome, dalemeade08540 [ ]Sign Out -My Yahoo! View Customize

    E-Print Network [OSTI]

    - - -Search Finance Home Yahoo! Help Welcome, dalemeade08540 [ ]Sign Out -My Yahoo! View Customize Financial News Enter symbol(s) Basic Get Symbol Lookup Associated Press EU Expected to Offer Japan Bigger, Russia, South Korea and China plan to join forces to research uses of fusion energy to create clean, long-term

  7. Spring 2014 View this email in your browser Hello from Berkeley Bioengineering!

    E-Print Network [OSTI]

    Alvarez-Cohen, Lisa

    Spring 2014 View this email in your browser Hello from Berkeley Bioengineering! It's been another program ranked 7th best in the U.S. New rankings from US News & World Report placed our bioengineeringth anniversary of the UC Berkeley - UCSF Graduate Program in Bioengineering, AIMBE Fellows Herr

  8. Characterization of BoLA class II genes 

    E-Print Network [OSTI]

    Sherwood, Sidney James

    1989-01-01

    or growth of the tumors was attributed to a genetically inherited system of about fifteen dominant genes. The last major step leading to Borer defining of the mouse MHC was the work done on human blood groups by Landsteiner (1901) and others... antigen. Second an Ir gene mutation that affects Ir gene control also carries amino acid 10 substitutions in the class II but in no other molecule. Third, immune response in vitro and in vivo can be manipulated by class II specific antibodies. Last...

  9. LATERAL GENE TRANSFER AND THE HISTORY OF BACTERIAL GENOMES

    SciTech Connect (OSTI)

    Howard Ochman

    2006-02-22

    The aims of this research were to elucidate the role and extent of lateral transfer in the differentiation of bacterial strains and species, and to assess the impact of gene transfer on the evolution of bacterial genomes. The ultimate goal of the project is to examine the dynamics of a core set of protein-coding genes (i.e., those that are distributed universally among Bacteria) by developing conserved primers that would allow their amplification and sequencing in any bacterial taxa. In addition, we adopted a bioinformatic approach to elucidate the extent of lateral gene transfer in sequenced genome.

  10. New methods for tightly regulated gene expression and highly efficient chromosomal integration of cloned genes for Methanosarcina species

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Guss, Adam M.; Rother, Michael; Zhang, Jun Kai; Kulkkarni, Gargi; Metcalf, William W.

    2008-01-01

    A highly efficient method for chromosomal integration of cloned DNA into Methanosarcina spp. was developed utilizing the site-specific recombination system from the Streptomyces phage ?C31. Host strains expressing the ?C31 integrase gene and carrying an appropriate recombination site can be transformed with non-replicating plasmids carrying the complementary recombination site at efficiencies similar to those obtained with self-replicating vectors. We have also constructed a series of hybrid promoters that combine the highly expressed M. barkeri P mcrB promoter with binding sites for the tetracycline-responsive, bacterial TetR protein. These promoters are tightly regulated by the presence or absence of tetracycline inmore »strains that express the tetR gene. The hybrid promoters can be used in genetic experiments to test gene essentiality by placing a gene of interest under their control. Thus, growth of strains with tetR -regulated essential genes becomes tetracycline-dependent. A series of plasmid vectors that utilize the site-specific recombination system for construction of reporter gene fusions and for tetracycline regulated expression of cloned genes are reported. These vectors were used to test the efficiency of translation at a variety of start codons. Fusions using an ATG start site were the most active, whereas those using GTG and TTG were approximately one half or one fourth as active, respectively. The CTG fusion was 95% less active than the ATG fusion. « less

  11. Prairie View 

    E-Print Network [OSTI]

    Unknown

    2011-08-17

    . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 108 APPENDIX C . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 109 APPENDIX D . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 110 APPENDIX E...-pair. Here subscripts ij are omitted from piijQ, piijA and piijB. Prob. = Probability. . . . 46 III Interval estimates of ??Q by piA, piB,?A and ?B, for the flanking markers separated by ?AB = 20 cM under Haldane?s mapping function...

  12. The use of ultrasound to facilitate the delivery of genetic-based therapeutic strategies

    E-Print Network [OSTI]

    Silcox, Christina, 1978-

    2004-01-01

    (cont.) preliminary experiments will eventually lead to a clinical methodology where ultrasound-enhanced gene therapy transfection would be followed with ultrasound-directed spatial control of gene expression.

  13. Transgenic mice expressing mutant Pinin exhibit muscular dystrophy, nebulin deficiency and elevated expression of slow-type muscle fiber genes

    SciTech Connect (OSTI)

    Wu, Hsu-Pin; Hsu, Shu-Yuan [Department of Anatomy, Chang Gung University Medical College, Taiwan (China)] [Department of Anatomy, Chang Gung University Medical College, Taiwan (China); Wu, Wen-Ai; Hu, Ji-Wei [Transgenic Mouse Core Laboratory, Chang Gung University, Taiwan (China)] [Transgenic Mouse Core Laboratory, Chang Gung University, Taiwan (China); Ouyang, Pin, E-mail: ouyang@mail.cgu.edu.tw [Department of Anatomy, Chang Gung University Medical College, Taiwan (China) [Department of Anatomy, Chang Gung University Medical College, Taiwan (China); Transgenic Mouse Core Laboratory, Chang Gung University, Taiwan (China); Molecular Medicine Research Center, Chang Gung University, Taiwan (China)

    2014-01-03

    Highlights: •Pnn CCD domain functions as a dominant negative mutant regulating Pnn expression and function. •Pnn CCD mutant Tg mice have a muscle wasting phenotype during development and show dystrophic histological features. •Pnn mutant muscles are susceptible to slow fiber type gene transition and NEB reduction. •The Tg mouse generated by overexpression of the Pnn CCD domain displays many characteristics resembling NEB{sup +/?} mice. -- Abstract: Pinin (Pnn) is a nuclear speckle-associated SR-like protein. The N-terminal region of the Pnn protein sequence is highly conserved from mammals to insects, but the C-terminal RS domain-containing region is absent in lower species. The N-terminal coiled-coil domain (CCD) is, therefore, of interest not only from a functional point of view, but also from an evolutionarily standpoint. To explore the biological role of the Pnn CCD in a physiological context, we generated transgenic mice overexpressing Pnn mutant in skeletal muscle. We found that overexpression of the CCD reduces endogenous Pnn expression in cultured cell lines as well as in transgenic skeletal muscle fibers. Pnn mutant mice exhibited reduced body mass and impaired muscle function during development. Mutant skeletal muscles show dystrophic histological features with muscle fibers heavily loaded with centrally located myonuclei. Expression profiling and pathway analysis identified over-representation of genes in gene categories associated with muscle contraction, specifically those related to slow type fiber. In addition nebulin (NEB) expression level is repressed in Pnn mutant skeletal muscle. We conclude that Pnn downregulation in skeletal muscle causes a muscular dystrophic phenotype associated with NEB deficiency and the CCD domain is incapable of replacing full length Pnn in terms of functional capacity.

  14. Effect of Nanoparticle Conjugation on Gene Silencing by RNA Interference

    E-Print Network [OSTI]

    Singh, Neetu

    RNA interference (RNAi) is a cellular process whereby the silencing of a particular gene is mediated by short RNAs (siRNAs). Although siRNAs have great therapeutic potential, cellular delivery has been a challenge. ...

  15. Auxiliary metabolic genes in viruses infecting marine cyanobacteria

    E-Print Network [OSTI]

    Thompson, Luke Richard

    2010-01-01

    Marine viruses shape the diversity and biogeochemical role of their microbial hosts. Cyanophages that infect the cyanobacteria Prochlorococcus and Synechococcus often carry metabolic genes not found in other bacteriophages. ...

  16. Genes with internal repeats require the THO complex for transcription

    E-Print Network [OSTI]

    Voynov, Vladimir

    2006-01-01

    A genome-wide screen for promoter-independent regulators of the Saccharomyces cerevisiae adhesin FLOII identified 37 novel regulators. Among the mutants with the strongest phenotype were the deletions of genes encoding ...

  17. Low-Rank Regularization for Learning Gene Expression Programs

    E-Print Network [OSTI]

    Ye, Guibo; Tang, Mengfan; Cai, Jian-Feng; Nie, Qing; Xie, Xiaohui; Muldoon, Mark R

    2013-01-01

    8 | Issue 12 | e82146 Low-Rank for Learning Gene ExpressionWe will call (3) the linear low-rank model in the following.so is its square root K 2 . Low-rank regularized nonlinear

  18. Intrinsic limits to gene regulation by global crosstalk

    E-Print Network [OSTI]

    Friedlander, Tamar; Guet, C?lin C; Barton, Nicholas H; Tka?ik, Gašper

    2015-01-01

    Gene regulation relies on the specificity of transcription factor (TF) - DNA interactions. In equilibrium, limited specificity may lead to crosstalk: a regulatory state in which a gene is either incorrectly activated due to noncognate TF-DNA interactions or remains erroneously inactive. We present a tractable biophysical model of global crosstalk, where many genes are simultaneously regulated by many TFs. We show that in the simplest regulatory scenario, a lower bound on crosstalk severity can be analytically derived solely from the number of (co)regulated genes and a suitable parameter that describes binding site similarity. Estimates show that crosstalk could present a significant challenge for organisms with low-specificity TFs, such as metazoans, unless they use appropriate regulation schemes. Strong cooperativity substantially decreases crosstalk, while joint regulation by activators and repressors, surprisingly, does not; moreover, certain microscopic details about promoter architecture emerge as global...

  19. Gene Function Prediction Based on Sequence or Expression Data

    E-Print Network [OSTI]

    Horan, Kevin

    2011-01-01

    highly enriched in heat stress-related genes (GO:0009408, p-respond specifically to heat stress and to a much lessergene functions involved in heat stress response pathways.

  20. Computational discovery of gene modules, regulatory networks and expression programs

    E-Print Network [OSTI]

    Gerber, Georg Kurt, 1970-

    2007-01-01

    High-throughput molecular data are revolutionizing biology by providing massive amounts of information about gene expression and regulation. Such information is applicable both to furthering our understanding of fundamental ...