Sample records for frequency regulation signal

  1. Frequency regulator for synchronous generators

    DOE Patents [OSTI]

    Karlicek, R.F.

    1982-08-10T23:59:59.000Z

    The present invention is directed to a novel frequency regulator which controls a generator output frequency for variations in both the input power to the generator and the power supplied to an uncontrolled external load. The present invention further includes over current and current balance protection devices which are relatively inexpensive to manufacture, which may be encapsulated to provide protection from the operating environment and which respond more quickly than previously known electromechanical devices. 11 figs.

  2. EA-1631: Beacon Power Corporation Frequency Regulation Facility...

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    1: Beacon Power Corporation Frequency Regulation Facility in Stephentown, NY EA-1631: Beacon Power Corporation Frequency Regulation Facility in Stephentown, NY February 2, 2009...

  3. Frequency Regulation Basics and Trends

    SciTech Connect (OSTI)

    Kirby, BJ

    2005-05-06T23:59:59.000Z

    The electric power system must address two unique requirements: the need to maintain a near real-time balance between generation and load, and the need to adjust generation (or load) to manage power flows through individual transmission facilities. These requirements are not new: vertically integrated utilities have been meeting them for a century as a normal part of conducting business. With restructuring, however, the services needed to meet these requirements, now called ''ancillary services'', are being more clearly defined. Ancillary services are those functions performed by the equipment and people that generate, control, and transmit electricity in support of the basic services of generating capacity, energy supply, and power delivery. The Federal Energy Regulatory Commission (FERC) has defined such services as those ''necessary to support the transmission of electric power from seller to purchaser given the obligations of control areas and transmitting utilities within those control areas to maintain reliable operations of the interconnected transmission system''. This statement recognizes the importance of ancillary services for both bulk-power reliability and support of commercial transactions. Balancing generation and load instantaneously and continuously is difficult because loads and generators are constantly fluctuating. Minute-to-minute load variability results from the random turning on and off of millions of individual loads. Longer-term variability results from predictable factors such as the daily and seasonal load patterns as well as more random events like shifting weather patterns. Generators also introduce unexpected fluctuations because they do not follow their generation schedules exactly and they trip unexpectedly due to a range of equipment failures. The output from wind generators varies with the wind. Storage technologies should be ideal suppliers of several ancillary services, including regulation, contingency reserves (spinning reserve, supplemental reserve, replacement reserve), and voltage support. These services are not free; in regions with energy markets, generators are paid to supply these services. In vertically integrated utilities (without energy markets) the utility incurs significant costs to supply these services. Supplying these services may be a significant business opportunity for emerging storage technologies. This report briefly explores the various ancillary services that may be of interest to storage. It then focuses on regulation, the most expensive ancillary service. It also examines the impact that increasing amounts of wind generation may have on regulation requirements, decreasing conventional regulation supplies, and the implications for energy storage.

  4. Neurofibromin Regulation of ERK Signaling Modulates

    E-Print Network [OSTI]

    Silva, Alcino

    Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning Yijun Cui,1 Rui M@mednet.ucla.edu DOI 10.1016/j.cell.2008.09.060 SUMMARY We uncovered a role for ERK signaling in GABA re- lease, long demonstrate that neurofibromin modulates ERK/synapsin I-dependent GABA re- lease, which in turn modulates

  5. Energy storage for frequency regulation on the electric grid

    E-Print Network [OSTI]

    Leitermann, Olivia

    2012-01-01T23:59:59.000Z

    Ancillary services such as frequency regulation are required for reliable operation of the electric grid. Currently, the same traditional thermal generators that supply bulk power also perform nearly all frequency regulation. ...

  6. (U) modulator to provide a continuous stepped frequency signal format

    DOE Patents [OSTI]

    Walters, Glenn A. (Escondido, CA)

    1991-01-01T23:59:59.000Z

    A modulator provides a continuous signal format composed of discrete freqcy steps and is designed to eliminate frequency overlap or smearing normally associated with filter ringing.

  7. Frequency Regulation from Flexible Loads: Potential, Economics, and Implementation

    E-Print Network [OSTI]

    Sanandaji, Borhan M.

    regulation procurement by as much as 40% [4]. This issue has been recognized in the power and energy system energy capacity into the day-ahead regulation market, and CAISO will dispatch these resources soFrequency Regulation from Flexible Loads: Potential, Economics, and Implementation He Hao1,, Borhan

  8. Characterization of Cardio signals by time-frequency domain analysis

    E-Print Network [OSTI]

    Sayan Mukherjee; Sanjay Kumar Palit; Santo Banerjee; MRK Ariffin; Lamberto Rondoni; Dilip Kumar Bhattacharya

    2014-09-04T23:59:59.000Z

    Long term behavior of nonlinear deterministic continuous time signals can be studied in terms of their reconstructed attractors. Reconstructed attractors of a continuous signal are meant to be topologically equivalent representations of the dynamics of the unknown dynamical system which generates the signal. Sometimes, geometry of the attractor or its complexity may give important information on the system of interest. However, if the trajectories of the attractor behave as if they are not coming from continuous system or there exists many spike like structures on the path of the system trajectories, then there is no way to characterize the shape of the attractor. In this article, the traditional attractor reconstruction method is first used for two types of ECG signals: Normal healthy persons (NHP) and Congestive Heart failure patients (CHFP). As common in such a framework, the reconstructed attractors are not at all well formed and hence it is not possible to adequately characterize their geometrical features. Thus, we incorporate frequency domain information to the given time signals. This is done by transforming the signals to a time frequency domain by means of suitable Wavelet transforms (WT). The transformed signal concerns two non homogeneous variables and is still quite difficult to use to reconstruct some dynamics out of it. By applying a suitable mapping, this signal is further converted into integer domain and a new type of 3D plot, called integer lag plot, which characterizes and distinguishes the ECG signals of NHP and CHFP, is finally obtained.

  9. Reliability of frequency- and amplitude-decoding in gene regulation

    E-Print Network [OSTI]

    Filipe Tostevin; Wiet de Ronde; Pieter Rein ten Wolde

    2012-02-07T23:59:59.000Z

    In biochemical signaling, information is often encoded in oscillatory signals. However, the advantages of such a coding strategy over an amplitude encoding scheme of constant signals remain unclear. Here we study the dynamics of a simple model gene promoter in response to oscillating and constant transcription factor signals. We find that in biologically-relevant parameter regimes an oscillating input can produce a more constant protein level than a constant input. Our results suggest that oscillating signals may be used to minimize noise in gene regulation.

  10. Autonomous Demand Response for Primary Frequency Regulation

    SciTech Connect (OSTI)

    Donnelly, Matt; Trudnowski, Daniel J.; Mattix, S.; Dagle, Jeffery E.

    2012-02-28T23:59:59.000Z

    The research documented within this report examines the use of autonomous demand response to provide primary frequency response in an interconnected power grid. The work builds on previous studies in several key areas: it uses a large realistic model (i.e., the interconnection of the western United States and Canada); it establishes a set of metrics that can be used to assess the effectiveness of autonomous demand response; and it independently adjusts various parameters associated with using autonomous demand response to assess effectiveness and to examine possible threats or vulnerabilities associated with the technology.

  11. A system for tranmitting low frequency analog signals over ac power lines

    DOE Patents [OSTI]

    Baker, S.P.; Durall, R.L.; Haynes, H.D.

    1987-07-30T23:59:59.000Z

    A system for transmitting low frequency analog signals over ac power lines using FM modulation. A low frequency analog signal to be transmitted is first applied to a voltage-to-frequency converter where it is converted to a signal whose frequency varies in proportion to the analog signal amplitude. This signal is then used to modulate the carrier frequency of an FM transmitter coupled to an ac power line. The modulation signal frequency range is selected to be within the response band of the FM transmitter. The FM modulated carrier signal is received by an FM receiver coupled to the ac power line, demodulated and the demodulated signal frequency is converted by a frequency-to-voltage converter back to the form of the original low frequency analog input signal. 4 figs.

  12. ORIGINAL ARTICLE FGF and ERK signaling coordinately regulate mineralization-

    E-Print Network [OSTI]

    ORIGINAL ARTICLE FGF and ERK signaling coordinately regulate mineralization- related genes and play for Bone and Mineral Research and Springer 2011 Abstract To examine the roles of FGF and ERK MAPK signaling in an ERK MAPK-dependent manner. Real-time PCR analysis indicated that FGF2 upregulates Ank, Enpp1, Mgp, Slc

  13. Ramanujan sums for signal processing of low frequency noise

    E-Print Network [OSTI]

    M. Planat; H. C. Rosu; S. Perrine

    2002-09-01T23:59:59.000Z

    An aperiodic (low frequency) spectrum may originate from the error term in the mean value of an arithmetical function such as M\\"obius function or Mangoldt function, which are coding sequences for prime numbers. In the discrete Fourier transform the analyzing wave is periodic and not well suited to represent the low frequency regime. In place we introduce a new signal processing tool based on the Ramanujan sums c_q(n), well adapted to the analysis of arithmetical sequences with many resonances p/q. The sums are quasi-periodic versus the time n of the resonance and aperiodic versus the order q of the resonance. New results arise from the use of this Ramanujan-Fourier transform (RFT) in the context of arithmetical and experimental signals

  14. Oscillatory Dynamics of the Extracellular Signal-regulated Kinase Pathway

    SciTech Connect (OSTI)

    Shankaran, Harish; Wiley, H. S.

    2010-12-01T23:59:59.000Z

    The extracellular signal-regulated kinase (ERK) pathway is a central signaling pathway in development and disease and is regulated by multiple negative and positive feedback loops. Recent studies have shown negative feedback from ERK to upstream regulators can give rise to biochemical oscillations with a periodicity of between 15-30 minutes. Feedback due to the stimulated transcription of negative regulators of the ERK pathway can also give rise to transcriptional oscillations with a periodicity of 1-2h. The biological significance of these oscillations is not clear, but recent evidence suggests that transcriptional oscillations participate in developmental processes, such as somite formation. Biochemical oscillations are more enigmatic, but could provide a mechanism for encoding different types of inputs into a common signaling pathway.

  15. Signal Transduction Pathways that Regulate CAB Gene Expression

    SciTech Connect (OSTI)

    Chory, Joanne

    2006-01-16T23:59:59.000Z

    The process of chloroplast differentiation, involves the coordinate regulation of many nuclear and chloroplast genes. The cues for the initiation of this developmental program are both extrinsic (e.g., light) and intrinsic (cell-type and plastid signals). During this project period, we utilized a molecular genetic approach to select for Arabidopsis mutants that did not respond properly to environmental light conditions, as well as mutants that were unable to perceive plastid damage. These latter mutants, called gun mutants, define two retrograde signaling pathways that regulate nuclear gene expression in response to chloroplasts. A major finding was to identify a signal from chloroplasts that regulates nuclear gene transcription. This signal is the build-up of Mg-Protoporphyrin IX, a key intermediate of the chlorophyll biosynthetic pathway. The signaling pathways downstream of this signal are currently being studied. Completion of this project has provided an increased understanding of the input signals and retrograde signaling pathways that control nuclear gene expression in response to the functional state of chloroplasts. These studies should ultimately influence our abilities to manipulate plant growth and development, and will aid in the understanding of the developmental control of photosynthesis.

  16. Signal Transduction Pathways that Regulate CAB Gene Expression

    SciTech Connect (OSTI)

    Chory, Joanne

    2004-12-31T23:59:59.000Z

    The process of chloroplast differentiation, involves the coordinate regulation of many nuclear and chloroplast genes. The cues for the initiation of this developmental program are both extrinsic (e.g., light) and intrinsic (cell-type and plastid signals). During this project period, we utilized a molecular genetic approach to select for Arabidopsis mutants that did not respond properly to environmental light conditions, as well as mutants that were unable to perceive plastid damage. These latter mutants, called gun mutants, define two retrograde signaling pathways that regulate nuclear gene expression in response to chloroplasts. A major finding was to identify a signal from chloroplasts that regulates nuclear gene transcription. This signal is the build-up of Mg-Protoporphyrin IX, a key intermediate of the chlorophyll biosynthetic pathway. The signaling pathways downstream of this signal are currently being studied. Completion of this project has provided an increased understanding of the input signals and retrograde signaling pathways that control nuclear gene expression in response to the functional state of chloroplasts. These studies should ultimately influence our abilities to manipulate plant growth and development, and will aid in the understanding of the developmental control of photosynthesis.

  17. Investigation of the Moessbauer Spectrum Quality as a Dependence on the Frequency of the Velocity Signal

    SciTech Connect (OSTI)

    Pechousek, J. [Centre for Nanomaterial Research, Faculty of Science, Palacky University, Slechtitelu 11, 783 71, Olomouc (Czech Republic); Department of Experimental Physics, Faculty of Science, Palacky University, 17, listopadu 1192/12, 771 46, Olomouc (Czech Republic); Prochazka, R.; Cuda, J.; Frydrych, J.; Jancik, D. [Centre for Nanomaterial Research, Faculty of Science, Palacky University, Slechtitelu 11, 783 71, Olomouc (Czech Republic)

    2010-07-13T23:59:59.000Z

    This paper is focused on a quality characterizing the Moessbauer spectra measured for various frequencies of the velocity signal. Standard electromechanical double-loudspeaker drive and digital PID velocity controller were used for calibration spectra measurement in the frequency interval from 4 up to 100 Hz. Several parameters were evaluated for recommendation of the suitable velocity signal frequency.

  18. Comparison of Signals from Gravitational Wave Detectors with Instantaneous Time-Frequency Maps

    E-Print Network [OSTI]

    Alexander Stroeer; Lindy Blackburn; Jordan Camp

    2011-05-24T23:59:59.000Z

    Gravitational wave astronomy relies on the use of multiple detectors, so that coincident detections may distinguish real signals from instrumental artifacts, and also so that relative timing of signals can provide the sky position of sources. We show that the comparison of instantaneous time-frequency and time- amplitude maps provided by the Hilbert-Huang Transform (HHT) can be used effectively for relative signal timing of common signals, to discriminate between the case of identical coincident signals and random noise coincidences, and to provide a classification of signals based on their time-frequency trajectories. The comparison is done with a chi-square goodness-of-fit method which includes contributions from both the instantaneous amplitude and frequency components of the HHT to match two signals in the time domain. This approach naturally allows the analysis of waveforms with strong frequency modulation.

  19. Coherent-control of linear signals: Frequency-domain analysis Shaul Mukamel

    E-Print Network [OSTI]

    Mukamel, Shaul

    Coherent-control of linear signals: Frequency-domain analysis Shaul Mukamel Citation: The Journal, 164113 (2013) Coherent-control of linear signals: Frequency-domain analysis Shaul Mukamela) Department al.1 had demonstrated the coherent control of the photoisomerization of Rhodophin to linear order

  20. OPTIMAL TRAINING SIGNALS FOR SISO OFDM CHANNEL ESTIMATION IN THE ABSENCE/PRESENCE OF FREQUENCY OFFSETS

    E-Print Network [OSTI]

    Minn, Hlaing

    OPTIMAL TRAINING SIGNALS FOR SISO OFDM CHANNEL ESTIMATION IN THE ABSENCE/PRESENCE OF FREQUENCY.minn, aldhahir @utdallas.edu Abstract-- All existing training signal designs for channel estima- tion in OFDM the performance of OFDM systems. In this paper, we address the problem of design- ing optimal training signals

  1. Denoising and Frequency Analysis of Noninvasive Magnetoencephalography Sensor Signals for Functional Brain Mapping

    E-Print Network [OSTI]

    Ukil, A

    2015-01-01T23:59:59.000Z

    Magnetoencephalography (MEG) is an important noninvasive, nonhazardous technology for functional brain mapping, measuring the magnetic fields due to the intracellular neuronal current flow in the brain. However, most often, the inherent level of noise in the MEG sensor data collection process is large enough to obscure the signal(s) of interest. In this paper, a denoising technique based on the wavelet transform and the multiresolution signal decomposition technique along with thresholding is presented, substantiated by application results. Thereafter, different frequency analysis are performed on the denoised MEG signals to identify the major frequencies of the brain oscillations present in the denoised signals. Time-frequency plots (spectrograms) of the denoised signals are also provided.

  2. Requirements for Defining Utility Drive Cycles: An Exploratory Analysis of Grid Frequency Regulation Data for Establishing Battery Performance Testing Standards

    SciTech Connect (OSTI)

    Hafen, Ryan P.; Vishwanathan, Vilanyur V.; Subbarao, Krishnappa; Kintner-Meyer, Michael CW

    2011-10-19T23:59:59.000Z

    Battery testing procedures are important for understanding battery performance, including degradation over the life of the battery. Standards are important to provide clear rules and uniformity to an industry. The work described in this report addresses the need for standard battery testing procedures that reflect real-world applications of energy storage systems to provide regulation services to grid operators. This work was motivated by the need to develop Vehicle-to-Grid (V2G) testing procedures, or V2G drive cycles. Likewise, the stationary energy storage community is equally interested in standardized testing protocols that reflect real-world grid applications for providing regulation services. As the first of several steps toward standardizing battery testing cycles, this work focused on a statistical analysis of frequency regulation signals from the Pennsylvania-New Jersey-Maryland Interconnect with the goal to identify patterns in the regulation signal that would be representative of the entire signal as a typical regulation data set. Results from an extensive time-series analysis are discussed, and the results are explained from both the statistical and the battery-testing perspectives. The results then are interpreted in the context of defining a small set of V2G drive cycles for standardization, offering some recommendations for the next steps toward standardizing testing protocols.

  3. Detection of Stochastic Signals in the Frequency Domain

    E-Print Network [OSTI]

    So, Hing-Cheung

    of radiometers, energy detector and quadratic detector 2]. It is optimum if s(n) is a Gaussian bandlimited white and su ers a loss in detection performance which becomes sig- ni cant at high signal to noise ratios

  4. Time-Frequency Analysis of Non-Stationary Signals in Fusion Plasmas using the Choi-Williams Distribution

    E-Print Network [OSTI]

    Time-Frequency Analysis of Non-Stationary Signals in Fusion Plasmas using the Choi-Williams Distribution

  5. Time­Frequency Analysis of Non Stationary Signals in Fusion Plasmas using the Choi-Williams Distribution

    E-Print Network [OSTI]

    Time­Frequency Analysis of Non Stationary Signals in Fusion Plasmas using the Choi-Williams Distribution

  6. Wind/PV Generation for Frequency Regulation and Oscillation Damping in the Eastern Interconnection

    SciTech Connect (OSTI)

    Liu, Yong [The University of Tennessee, Knoxville; Gracia, Jose R [ORNL; Hadley, Stanton W [ORNL; Liu, Yilu [ORNL

    2013-12-01T23:59:59.000Z

    This report presents the control of renewable energy sources, including the variable-speed wind generators and solar photovoltaic (PV) generators, for frequency regulation and inter-area oscillation damping in the U.S. Eastern Interconnection (EI). In this report, based on the user-defined wind/PV generator electrical control model and the 16,000-bus Eastern Interconnection dynamic model, the additional controllers for frequency regulation and inter-area oscillation damping are developed and incorporated and the potential contributions of renewable energy sources to the EI system frequency regulation and inter-area oscillation damping are evaluated.

  7. System and method for constructing filters for detecting signals whose frequency content varies with time

    DOE Patents [OSTI]

    Qian, S.; Dunham, M.E.

    1996-11-12T23:59:59.000Z

    A system and method are disclosed for constructing a bank of filters which detect the presence of signals whose frequency content varies with time. The present invention includes a novel system and method for developing one or more time templates designed to match the received signals of interest and the bank of matched filters use the one or more time templates to detect the received signals. Each matched filter compares the received signal x(t) with a respective, unique time template that has been designed to approximate a form of the signals of interest. The robust time domain template is assumed to be of the order of w(t)=A(t)cos(2{pi}{phi}(t)) and the present invention uses the trajectory of a joint time-frequency representation of x(t) as an approximation of the instantaneous frequency function {phi}{prime}(t). First, numerous data samples of the received signal x(t) are collected. A joint time frequency representation is then applied to represent the signal, preferably using the time frequency distribution series. The joint time-frequency transformation represents the analyzed signal energy at time t and frequency f, P(t,f), which is a three-dimensional plot of time vs. frequency vs. signal energy. Then P(t,f) is reduced to a multivalued function f(t), a two dimensional plot of time vs. frequency, using a thresholding process. Curve fitting steps are then performed on the time/frequency plot, preferably using Levenberg-Marquardt curve fitting techniques, to derive a general instantaneous frequency function {phi}{prime}(t) which best fits the multivalued function f(t). Integrating {phi}{prime}(t) along t yields {phi}{prime}(t), which is then inserted into the form of the time template equation. A suitable amplitude A(t) is also preferably determined. Once the time template has been determined, one or more filters are developed which each use a version or form of the time template. 7 figs.

  8. Frequency Characteristics of Acoustic Emission Signals from Cementitious Waste-forms with Encapsulated Al

    SciTech Connect (OSTI)

    Spasova, Lyubka M.; Ojovan, Michael I. [Immobilisation Science Laboratory, Department of Engineering Materials, University of Sheffield, Mappin Street, Sheffield, S1 3JD (United Kingdom)

    2007-07-01T23:59:59.000Z

    Acoustic emission (AE) signals were continuously recorded and their intrinsic frequency characteristics examined in order to evaluate the mechanical performance of cementitious wasteform samples with encapsulated Al waste. The primary frequency in the power spectrum and its range of intensity for the detected acoustic waves were potentially related with appearance of different micro-mechanical events caused by Al corrosion within the encapsulating cement system. In addition the process of cement matrix hardening has been shown as a source of AE signals characterized with essentially higher primary frequency (above 2 MHz) compared with those due to Al corrosion development (below 40 kHz) and cement cracking (above 100 kHz). (authors)

  9. PEV-Based Combined Frequency and Voltage Regulation for Smart Grid

    E-Print Network [OSTI]

    Huang, Jianwei

    by either adjusting supply or changing demand. While various demand side management programs have used benefit both users and utilities. Index Terms--Smart grid, plug-in electric vehicles, demand side management, reactive power compensation, ancillary ser- vices, frequency regulation, voltage regulation

  10. Integrated circuit for processing a low-frequency signal from a seismic detector

    SciTech Connect (OSTI)

    Malashevich, N. I.; Roslyakov, A. S.; Polomoshnov, S. A., E-mail: S.Polomoshnov@tsen.ru; Fedorov, R. A. [Research and Production Complex 'Technological Center' of the Moscow Institute of Electronic Technology (Russian Federation)

    2011-12-15T23:59:59.000Z

    Specific features for the detection and processing of a low-frequency signal from a seismic detector are considered in terms of an integrated circuit based on a large matrix crystal of the 5507 series. This integrated circuit is designed for the detection of human movements. The specific features of the information signal, obtained at the output of the seismic detector, and the main characteristics of the integrated circuit and its structure are reported.

  11. Analysis and separation of time-frequency components in signals with chaotic behavior

    E-Print Network [OSTI]

    Benjamin Ricaud; Francoise Briolle; F. Clairet

    2010-05-31T23:59:59.000Z

    The analysis of chaotic signals with time-frequency methods is considered. For this purpose, two new transformations are presented which consist in the decomposition of a signal onto an orthogonal set of respectively linear and hyperbolic chirps. The linear chirp transformation is able to discriminate and extract particular chaotic components in non-stationary square integrable signals. This is demonstrated in an example studying the reflectometry measures of a turbulent plasma. The hyperbolic chirp transformation is designed for the detection and extraction of chaotic parts in self-similar processes such as stochastic motions. Mathematical connections are made between these two methods and other well-known transformations.

  12. The Regulation of Growth Factor Signaling in Drosophila Development and Disease

    E-Print Network [OSTI]

    Lindner, Jonathan Ryan

    2012-02-14T23:59:59.000Z

    Developmental signaling pathways have many diverse roles throughout the life of an organism. The proper regulation of these pathways is essential for normal development, and misregulation can lead to diseases such as cancer. Heparan sulfate...

  13. Association between Regulator of G Protein Signaling 9–2 and Body Weight

    E-Print Network [OSTI]

    Waugh, Jeffrey L.

    Regulator of G protein signaling 9–2 (RGS9–2) is a protein that is highly enriched in the striatum, a brain region that mediates motivation, movement and reward responses. We identified a naturally occurring 5 nucleotide ...

  14. A Mixed-SignalASIC Power-Factor-Correction(PFC) Controller for High Frequency Switching Rectifiers

    E-Print Network [OSTI]

    A Mixed-SignalASIC Power-Factor-Correction(PFC) Controller for High Frequency Switching Rectifiers,but control of other power stages could be derived in the same manner. The final controller is proposedas harmonic content [11-[4]. These controllers generally add complexity and cost to power systems

  15. A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling

    E-Print Network [OSTI]

    Perrimon, Norbert

    LETTERS A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling Adam-regulated kinases (ERKs) has pivotal roles during metazoan development, underlying processes as diverse as fate deter- mination, differentiation, proliferation, survival, migration and growth. Abnormal RTK/ERK

  16. Post-transcriptional regulation of ethylene perception and signaling in Arabidopsis

    SciTech Connect (OSTI)

    Schaller, George Eric

    2014-03-19T23:59:59.000Z

    The simple gas ethylene functions as an endogenous regulator of plant growth and development, and modulates such energy relevant processes as photosynthesis and biomass accumulation. Ethylene is perceived in the plant Arabidopsis by a five-member family of receptors related to bacterial histidine kinases. Our data support a general model in which the receptors exist as parts of larger protein complexes. Our goals have been to (1) characterize physical interactions among members of the signaling complex; (2) the role of histidine-kinase transphosphorylation in signaling by the complex; and (3) the role of a novel family of proteins that regulate signal output by the receptors.

  17. Frequency response testing at Experimental Breeder Reactor II using discrete-level periodic signals

    SciTech Connect (OSTI)

    Rhodes, W.D.; Larson, H.A. (Idaho State Univ., Pocatello, ID (USA). Coll. of Engineering); Dean, E.M. (Argonne National Lab., Idaho Falls, ID (USA))

    1990-01-01T23:59:59.000Z

    The Experimental Breeder Reactor 2 (EBR-2) reactivity-to-power frequency-response function was measured with pseudo-random, discrete-level, periodic signals. The reactor power deviation was small with insignificant perturbation of normal operation and in-place irradiation experiments. Comparison of results with measured rod oscillator data and with theoretical predictions show good agreement. Moreover, measures of input signal quality (autocorrelation function and energy spectra) confirm the ability to enable this type of frequency response determination at EBR-2. Measurements were made with the pseudo-random binary sequence, quadratic residue binary sequence, pseudo-random ternary sequence, and the multifrequency binary sequence. 10 refs., 7 figs., 3 tabs.

  18. ROP GTPase Signaling in The Hormonal Regulation of Plant Growth

    SciTech Connect (OSTI)

    Yang, Zhenbiao

    2013-05-24T23:59:59.000Z

    I secured funding from the DOE to investigate the effect of auxin signaling on ROP9. This was based on our preliminary data showing that ROP9 is activated by auxin. However, we were unable to show that rop9 knockout mutants have altered sensitivity to auxin. Instead, we found that auxin activates both ROP2 and ROP6, and relevant mutants exhibit reduced sensitivity to auxin. Therefore we used the fund to strengthen our research on ROP2 and ROP6. My laboratory made major advancements in the recent years in the understanding of the effect of auxin signaling on ROP2 and ROP6. This is clearly exemplified by the numerous publications acknowledging fund DE-FG0204ER15555 as the source of funding.

  19. Porcine circovirus type 2 replication is impaired by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway

    SciTech Connect (OSTI)

    Wei Li [Institute of Animal Husbandry and Veterinary Medicine, Beijing Municipal Academy of Agriculture and Forestry Sciences, No.9 Shuguang Garden Central Road, Haidian District, Beijing 100097 (China); Liu Jue [Institute of Animal Husbandry and Veterinary Medicine, Beijing Municipal Academy of Agriculture and Forestry Sciences, No.9 Shuguang Garden Central Road, Haidian District, Beijing 100097 (China)], E-mail: liujue@263.net

    2009-03-30T23:59:59.000Z

    Postweaning multisystemic wasting syndrome, which is primarily caused by porcine circovirus type 2 (PCV2), is an emerging and important swine disease. We have recently shown that PCV2 induces nuclear factor kappa B activation and its activation is required for active replication, but the other cellular factors involved in PCV2 replication are not well defined. The extracellular signal-regulated kinase (ERK) which served as an important component of cellular signal transduction pathways has been shown to regulate many viral infections. In this report, we show that PCV2 activates ERK1/2 in PCV2-infected PK15 cells dependent on viral replication. The PCV2-induced ERK1/2 leads to phosphorylation of the ternary complex factor Elk-1, which kinetically paralleled ERK1/2 activation. Inhibition of ERK activation with U0126, a specific MEK1/2 inhibitor, significantly reduced viral progeny release. Investigations into the mechanism of ERK1/2 regulation revealed that inhibition of ERK activation leads to decreased viral transcription and lower virus protein expression. These data indicate that the ERK signaling pathway is involved in PCV2 infection and beneficial to PCV2 replication in the cultured cells.

  20. Reagan win signals new direction in environmental regulation

    SciTech Connect (OSTI)

    Smock, R.

    1981-01-01T23:59:59.000Z

    Environmental policy under the Reagan Administration will experience a shift in direction as new administrators are named and the political balances in Congressional committees changes. Predictions of what may happen include the possible removal of regulations governing prevention of significant deterioration (PSD) and fugitive emissions, abolishing the Council on Environmental Quality, and weakening the Clean Air Act. Pressures to continue strict pollution controls reflect a growing concern about acid rain. Several steps that the Environmental Protection Agency could take without new legislation could affect national ambient-air-quality standards, enforcement of existing state plans, ambient sulfur dioxide and nitrogen emission standards, and stack heights. New scrubber trends show a shift to dry scrubbers. Test results show the superiority of limestone scrubbing, although a new dual-alkali system is doing well. Improved scrubbing technologies are proving to be efficient and economical ways to control pollution. 1 figure, 2 tables. (DCK)

  1. UNCORRECTEDPROOF Please cite this article in press as: Ramos JW, The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells, Int J Biochem Cell

    E-Print Network [OSTI]

    Ramos, Joe W.

    signal-regulated kinase (ERK) in mammalian cells, Int J Biochem Cell Biol (2008), doi:10.1016/j of extracellular signal-regulated kinase (ERK) in mammalian cells 2 3 Joe W. Ramos 2 Department of Natural Products Received in revised form 18 April 20089 Accepted 25 April 200810 Available online xxx11 12 Keywords:13 ERK

  2. Properties and Regulation of a Transiently Assembled ERK2,Ets-1 Signaling Complex

    E-Print Network [OSTI]

    Riggs, Austen

    Properties and Regulation of a Transiently Assembled ERK2,Ets-1 Signaling Complex Kari A. Callaway: ERK2 is a proline-directed protein kinase that displays a high specificity for a single threonine (Thr binds ERK2 to promote the phosphorylation of Thr-38 while simultaneously discriminating against

  3. Dynamic Switch of Negative Feedback Regulation in Drosophila AktTOR Signaling

    E-Print Network [OSTI]

    Perrimon, Norbert

    Dynamic Switch of Negative Feedback Regulation in Drosophila Akt­TOR Signaling Lutz Kockel1 Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, Massachusetts, United States of America, 4 Department of Cell and Tissue Biology, University of California San

  4. Cell signalling and gene regulation Exploring new functions and actions of regulatory molecules

    E-Print Network [OSTI]

    Sheen, Jen

    Cell signalling and gene regulation Exploring new functions and actions of regulatory molecules.pbi.2004.07.017 Jen Sheen Department of Molecular Biology, Wellman 11, Massachusetts General Hospital, Boston, Massachusetts 02114, USA e-mail: sheen@molbio.mgh.harvard.edu Jen's research group is interested

  5. An analysis on the mid-latitude scintillation and coherence frequency bandwidth using transionospheric VHF signals

    SciTech Connect (OSTI)

    Juang, Zhen [Los Alamos National Laboratory; Roussel-dupre, Robert [Los Alamos National Laboratory

    2008-01-01T23:59:59.000Z

    An analysis was perfonned on the mid-latitude scintillation and coherence frequency bandwidth (Fcoh) using transionospheric VHF signal data. The data include 1062 events spanning from November 1997 to June 2002. Each event records FORTE satellite received VHF signals from LAPP located at Los Alamos, New Mexico. Fcohs were derived to study scintillation characteristics on diurnal and seasonal variations, as well as changes due to solar and geomagnetic activities. Comparisons to the VHFIUHF coherence frequency bandwidth studies previously reported at equatorial and mid-latitude regions are made using a 4th power frequency dependence relationship. Furthennore, a wideband ionospheric scintillation model, WBMOD, was used to estimate Fcohs and compared with our VHF Fcoh values. Our analysis indicates mid-latitude scintillation characteristics that are not previously revealed. At the VHF bottom frequency range (3035 MHz), distinguished smaller Fcohs are found in time period from sunset to midnight, in wann season from May to August, and in low solar activity years. The effects of geomagnetic storm activity on Fcoh are characterized by a sudden transition at a Kp index of 50-60. Comparisons with median Fcohs estimated from other studies validated our VHF Fcohs for daytime while an order of magnitude larger Fcohs are found for nighttime, implying a time-dependent issue in applying the 4th order power relationship. Furthermore, comparisons with WBMOD-estimated Fcohs indicated generally matched median scintillation level estimates while differences do exist for those events undergoing high geomagnetic stonn activity which may imply underestimates of scintillation level by the WBMOD in the mid-latitude regions.

  6. Edgar Nett Mobile Computer Communication SS'14 22 Using Spreading for all signals of a frequency band

    E-Print Network [OSTI]

    Edgar Nett Mobile Computer Communication SS'14 22 Using Spreading for all signals of a frequency to using FDM 2 2 2 2 2 frequency channel quality 1 spread spectrum spread spectrum channels #12;Edgar Nett of the receivers q Perfect synchronization of senders and receivers #12;Edgar Nett Mobile Computer Communication SS

  7. Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins

    E-Print Network [OSTI]

    Jason W. Locasale; Arup K. Chakraborty

    2008-10-29T23:59:59.000Z

    Scaffolding proteins that direct the assembly of multiple kinases into a spatially localized signaling complex are often essential for the maintenance of an appropriate biological response. Although scaffolds are widely believed to have dramatic effects on the dynamics of signal propagation, the mechanisms that underlie these consequences are not well understood. Here, Monte Carlo simulations of a model kinase cascade are used to investigate how the temporal characteristics of signaling cascades can be influenced by the presence of scaffold proteins. Specifically, we examine the effects of spatially localizing kinase components on a scaffold on signaling dynamics. The simulations indicate that a major effect that scaffolds exert on the dynamics of cell signaling is to control how the activation of protein kinases is distributed over time. Scaffolds can influence the timing of kinase activation by allowing for kinases to become activated over a broad range of times, thus allowing for signaling at both early and late times. Scaffold concentrations that result in optimal signal amplitude also result in the broadest distributions of times over which kinases are activated. These calculations provide insights into one mechanism that describes how the duration of a signal can potentially be regulated in a scaffold mediated protein kinase cascade. Our results illustrate another complexity in the broad array of control properties that emerge from the physical effects of spatially localizing components of kinase cascades on scaffold proteins.

  8. Coordinated Control and Optimization of Virtual Power Plants for Energy and Frequency Regulation Services in Electricity Markets 

    E-Print Network [OSTI]

    Zhang, Fan

    2012-02-14T23:59:59.000Z

    With increasing penetration of intermittent resources such as wind and solar, power system operations are facing much more challenges in cost effective provision of energy balancing and frequency regulation services. Enabled by advances in sensing...

  9. Time-frequency analysis of non-stationary fusion plasma signals using an improved Hilbert-Huang transform

    SciTech Connect (OSTI)

    Liu, Yangqing, E-mail: liuyq05@gmail.com; Tan, Yi; Xie, Huiqiao; Wang, Wenhao; Gao, Zhe [Department of Engineering Physics, Tsinghua University, Beijing 100084 (China)

    2014-07-15T23:59:59.000Z

    An improved Hilbert-Huang transform method is developed to the time-frequency analysis of non-stationary signals in tokamak plasmas. Maximal overlap discrete wavelet packet transform rather than wavelet packet transform is proposed as a preprocessor to decompose a signal into various narrow-band components. Then, a correlation coefficient based selection method is utilized to eliminate the irrelevant intrinsic mode functions obtained from empirical mode decomposition of those narrow-band components. Subsequently, a time varying vector autoregressive moving average model instead of Hilbert spectral analysis is performed to compute the Hilbert spectrum, i.e., a three-dimensional time-frequency distribution of the signal. The feasibility and effectiveness of the improved Hilbert-Huang transform method is demonstrated by analyzing a non-stationary simulated signal and actual experimental signals in fusion plasmas.

  10. Readout for intersatellite laser interferometry: Measuring low frequency phase fluctuations of HF signals with microradian precision

    E-Print Network [OSTI]

    Gerberding, Oliver; Kullmann, Joachim; Tröbs, Michael; Bykov, Ioury; Barke, Simon; Brause, Nils Christopher; Delgado, Juan José Esteban; Schwarze, Thomas S; Reiche, Jens; Danzmann, Karsten; Rasmussen, Torben; Hansen, Torben Vendt; Engaard, Anders; Pedersen, Søren Møller; Jennrich, Oliver; Suess, Martin; Sodnik, Zoran; Heinzel, Gerhard

    2015-01-01T23:59:59.000Z

    Precision phase readout of optical beat note signals is one of the core techniques required for intersatellite laser interferometry. Future space based gravitational wave detectors like eLISA require such a readout over a wide range of MHz frequencies, due to orbit induced Doppler shifts, with a precision in the order of $\\mu \\textrm{rad}/\\sqrt{\\textrm{Hz}}$ at frequencies between $0.1\\,\\textrm{mHz}$ and $1\\,\\textrm{Hz}$. In this paper, we present phase readout systems, so-called phasemeters, that are able to achieve such precisions and we discuss various means that have been employed to reduce noise in the analogue circuit domain and during digitisation. We also discuss the influence of some non-linear noise sources in the analogue domain of such phasemeters. And finally, we present the performance that was achieved during testing of the elegant breadboard model of the LISA phasemeter, that was developed in the scope of an ESA technology development activity.

  11. Identification of novel substrates of the energy-sensing kinase, AMP-activated protein kinase, and regulation of mTOR signaling during energy stress and mitosis

    E-Print Network [OSTI]

    Gwinn, Dana Meredith

    2011-01-01T23:59:59.000Z

    J. (2007b). Energy-dependent regulation of cell structure byis essential for energy homeostasis regulation and glucoseKinase, and Regulation of mTOR Signaling During Energy

  12. GEO-LOCATION ESTIMATION FROM ELECTRICAL NETWORK FREQUENCY SIGNALS Ravi Garg, Adi Hajj-Ahmad, and Min Wu

    E-Print Network [OSTI]

    Wu, Min

    GEO-LOCATION ESTIMATION FROM ELECTRICAL NETWORK FREQUENCY SIGNALS Ravi Garg, Adi Hajj-Ahmad, and Min Wu {ravig, adiha, minwu}@umd.edu University of Maryland, College Park, MD, USA. ABSTRACT Electric data collected across different locations in the eastern grid of the United States to understand

  13. A Test of Vehicle-to-Grid (V2G) for Energy Storage and Frequency Regulation in the PJM

    E-Print Network [OSTI]

    Firestone, Jeremy

    A Test of Vehicle-to-Grid (V2G) for Energy Storage and Frequency Regulation in the PJM System energy storage for intermittent but renewable resources such as wind and solar. The results of the study frequent dispatch. The primary revenue in both of these markets is for capacity rather than energy

  14. Human Glucocorticoid-Induced TNF Receptor Ligand Regulates its Signaling Activity Through Multiple Oligomerization States

    SciTech Connect (OSTI)

    Zhou,Z.; Dong, X.; Berezov, A.; Zhang, G.; Li, Y.; Zhang, H.; Murali, R.; Li, B.; Greene, M.

    2008-01-01T23:59:59.000Z

    Ligation between glucocorticoid-induced tumor necrosis factor receptor (GITR) and its ligand (GITRL) provides an undefined signal that renders CD4+CD25- effector T cells resistant to the inhibitory effects of CD4+CD25+ regulatory T cells. To understand the structural basis of GITRL function, we have expressed and purified the extracellular domain of human GITR ligand in Escherichia coli. Chromotography and cross-linking studies indicate that human GITRL (hGITRL) exists as dimers and trimers in solution and also can form a supercluster. To gain insight into the nature of GITRL oligomerization, we determined the crystallographic structures of hGITRL, which revealed a loosely associated open trimer with a deep cavity at the molecular center and a flexible C-terminal tail bent for trimerization. Moreover, a tetramer of trimers (i.e., supercluster) has also been observed in the crystal, consistent with the cross-linking analysis. Deletion of the C-terminal distal three residues disrupts the loosely assembled trimer and favors the formation of a dimer that has compromised receptor binding and signaling activity. Collectively, our studies identify multiple oligomeric species of hGITRL that possess distinct kinetics of ERK activation. The studies address the functional implications and structural models for a process by which hGITRL utilizes multiple oligomerization states to regulate GITR-mediated signaling during T cell costimulation.

  15. Vascular endothelial growth factor signaling regulates the segregation of artery and vein via ERK activity during vascular development

    SciTech Connect (OSTI)

    Kim, Se-Hee [McAllister Heart Institute, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States)] [McAllister Heart Institute, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States); Schmitt, Christopher E.; Woolls, Melissa J. [McAllister Heart Institute, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States) [McAllister Heart Institute, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States); Yale Cardiovascular Research Center and Section of Cardiovascular Medicine, Dept. of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511 (United States); Holland, Melinda B. [McAllister Heart Institute, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States)] [McAllister Heart Institute, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (United States); Kim, Jun-Dae [Yale Cardiovascular Research Center and Section of Cardiovascular Medicine, Dept. of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511 (United States)] [Yale Cardiovascular Research Center and Section of Cardiovascular Medicine, Dept. of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511 (United States); Jin, Suk-Won, E-mail: suk-won.jin@yale.edu [Yale Cardiovascular Research Center and Section of Cardiovascular Medicine, Dept. of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511 (United States)] [Yale Cardiovascular Research Center and Section of Cardiovascular Medicine, Dept. of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511 (United States)

    2013-01-25T23:59:59.000Z

    Highlights: ? VEGF-A signaling regulates the segregation of axial vessels. ? VEGF-A signaling is mediated by PKC and ERK in this process. ? Ectopic activation of ERK is sufficient to rescue defects in vessel segregation. -- Abstract: Segregation of two axial vessels, the dorsal aorta and caudal vein, is one of the earliest patterning events occur during development of vasculature. Despite the importance of this process and recent advances in our understanding on vascular patterning during development, molecular mechanisms that coordinate the segregation of axial vessels remain largely elusive. In this report, we find that vascular endothelial growth factor-A (Vegf-A) signaling regulates the segregation of dorsal aorta and axial vein during development. Inhibition of Vegf-A pathway components including ligand Vegf-A and its cognate receptor Kdrl, caused failure in segregation of axial vessels in zebrafish embryos. Similarly, chemical inhibition of Mitogen-activated protein kinase kinase (Map2k1)/Extracellular-signal-regulated kinases (Erk) and phosphatidylinositol 3-kinases (PI3 K), which are downstream effectors of Vegf-A signaling pathway, led to the fusion of two axial vessels. Moreover, we find that restoring Erk activity by over-expression of constitutively active MEK in embryos with a reduced level of Vegf-A signaling can rescue the defects in axial vessel segregation. Taken together, our data show that segregation of axial vessels requires the function of Vegf-A signaling, and Erk may function as the major downstream effector in this process.

  16. Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

    SciTech Connect (OSTI)

    Soon, Fen-Fen; Ng, Ley-Moy; Zhou, X. Edward; West, Graham M.; Kovach, Amanda; Tan, M.H. Eileen; Suino-Powell, Kelly M.; He, Yuanzheng; Xu, Yong; Chalmers, Michael J.; Brunzelle, Joseph S.; Zhang, Huiming; Yang, Huaiyu; Jiang, Hualiang; Li, Jun; Yong, Eu-Leong; Cutler, Sean; Zhu, Jian-Kang; Griffin, Patrick R.; Melcher, Karsten; Xu, H. Eric (Van Andel); (Scripps); (NWU); (Purdue); (UCR); (Chinese Aca. Sci.); (NU Singapore)

    2014-10-02T23:59:59.000Z

    Abscisic acid (ABA) is an essential hormone for plants to survive environmental stresses. At the center of the ABA signaling network is a subfamily of type 2C protein phosphatases (PP2Cs), which form exclusive interactions with ABA receptors and subfamily 2 Snfl-related kinase (SnRK2s). Here, we report a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors. In the complex, the kinase activation loop docks into the active site of PP2C, while the conserved ABA-sensing tryptophan of PP2C inserts into the kinase catalytic cleft, thus mimicking receptor-PP2C interactions. These structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites.

  17. TIME-FREQUENCY-PHASE COHERENCE GENERAL FRAMEWORK FOR SIGNAL ANALYSIS IN PASSIVE CONTEXT

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    behavior (underwater mammals vocalizations) and electronic warfare will prove the efficiency case, the passive behavior of the signal intelligence field is a well-known problem in the electronic warfare problem. In this paper we propose a general signal analysis framework in passive context. We show

  18. Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1–S6K pathway signaling

    E-Print Network [OSTI]

    Lindquist, Robert A.

    The evolutionarily conserved target of rapamycin complex 1 (TORC1) controls cell growth in response to nutrient availability and growth factors. TORC1 signaling is hyperactive in cancer, and regulators of TORC1 signaling ...

  19. Improved Battery Models of an Aggregation of Thermostatically Controlled Loads for Frequency Regulation

    E-Print Network [OSTI]

    Sanandaji, Borhan M.

    Integration and Regulating Reserve Service Vast and deep integration of renewable energy resources, stochasticity, and intermittency characteristics of renewable energies, however, present challenges hand, an increased penetration of renewable energies results in higher regulation requirements

  20. Current mode integrators and their applications in low-voltage high frequency CMOS signal processing

    E-Print Network [OSTI]

    1993-01-01T23:59:59.000Z

    Low voltage CMOS fully differential integrators for high frequency continuous-time filters using current-mode techniques are presented.. Current mode techniques are employed to avoid the use of the floating differential pair, in order to achieve...

  1. Supplementary Information for Friedman and Perrimon, "A functional genomic RNAi screen for novel regulators of RTK and ERK signaling," 2006.

    E-Print Network [OSTI]

    Higgins, Darren

    regulators of RTK and ERK signaling," 2006. Supplementary Methods Genome-wide RNAi Screening The genome of S2R+ cells overexpressing cDNAs for the Drosophila ERK ortholog Rolled, tagged at its CUAST and expressed under actinGal4 control. We observed similar kinetics of ERK activation in response to stimulus

  2. Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release from PC12 Cells

    E-Print Network [OSTI]

    Linial, Michal

    Involvement of Extracellular Signal-Regulated Kinase (ERK) in Pardaxin-Induced Dopamine Release kinase (ERK)/mitogen-activated protein kinase (MAPK) in pardaxin-induced dopamine (DA) release DA release. Time course exper- iments indicated that PX, at nontoxic concentrations, stimu- lated ERK

  3. Comparison of signal to noise ratios from spatial and frequency domain formulations of nonprewhitening model observers in digital mammography

    SciTech Connect (OSTI)

    Sisini, Francesco; Zanca, Federica; Marshall, Nicholas W.; Taibi, Angelo; Cardarelli, Paolo; Bosmans, Hilde [Dipartimento di Fisica dell' Universita di Ferrara, Via Saragat 1, I-44122 Ferrara, Italy and (Italy); Department of Radiology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven (Belgium); Department of Radiology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven (Belgium); Dipartimento di Fisica dell' Universita di Ferrara, Via Saragat 1, I-44122 Ferrara (Italy); Department of Radiology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven (Belgium)

    2012-09-15T23:59:59.000Z

    Purpose: Image quality indices based upon model observers are promising alternatives to laborious human readings of contrast-detail images. This is especially appealing in digital mammography as limiting values for contrast thresholds determine, according to some international protocols, the acceptability of these systems in the radiological practice. The objective of the present study was to compare the signal to noise ratios (SNR) obtained with two nonprewhitening matched filter model observer approaches, one in the spatial domain and the other in the frequency domain, and with both of them worked out for disks as present in the CDMAM phantom. Methods: The analysis was performed using images acquired with the Siemens Novation and Inspiration digital mammography systems. The spatial domain formulation uses a series of high dose CDMAM images as the signal and a routine exposure of two flood images to calculate the covariance matrix. The frequency domain approach uses the mathematical description of a disk and modulation transfer function (MTF) and noise power spectrum (NPS) calculated from images. Results: For both systems most of the SNR values calculated in the frequency domain were in very good agreement with the SNR values calculated in the spatial domain. Both the formulations in the frequency domain and in the spatial domain show a linear relationship between SNR and the diameter of the CDMAM discs. Conclusions: The results suggest that both formulations of the model observer lead to very similar figures of merit. This is a step forward in the adoption of figures of merit based on NPS and MTF for the acceptance testing of mammography systems.

  4. Validation of Multiple Hypothesis RAIM Algorithm Using Dual-frequency GNSS Signals

    E-Print Network [OSTI]

    Stanford University

    imposed by the Federal Aviation Administration (FAA) and International Civil Aviation Organization (ICAO- frequency flight data obtained by courtesy of the FAA Technical Center. An important part of this process errors are critical during aviation precision approaches, and they are also generally greater than

  5. Quality factor tuning of high-frequency high-Q filter biquads using adaptive signal processing 

    E-Print Network [OSTI]

    Stevenson, Jan-Michael

    1997-01-01T23:59:59.000Z

    A quality factor (Q) tuning technique for high-frequency and high-Q continuous-time filter biquads is proposed. The method is based on the existing magnitude locked loop Q-tuning technique, but it utilizes the continuous-time adaptive LMS algorithm...

  6. Modeling of GE Appliances: Cost Benefit Study of Smart Appliances in Wholesale Energy, Frequency Regulation, and Spinning Reserve Markets

    SciTech Connect (OSTI)

    Fuller, Jason C.; Parker, Graham B.

    2012-12-31T23:59:59.000Z

    This report is the second in a series of three reports describing the potential of GE’s DR-enabled appliances to provide benefits to the utility grid. The first report described the modeling methodology used to represent the GE appliances in the GridLAB-D simulation environment and the estimated potential for peak demand reduction at various deployment levels. The third report will explore the technical capability of aggregated group actions to positively impact grid stability, including frequency and voltage regulation and spinning reserves, and the impacts on distribution feeder voltage regulation, including mitigation of fluctuations caused by high penetration of photovoltaic distributed generation. In this report, a series of analytical methods were presented to estimate the potential cost benefit of smart appliances while utilizing demand response. Previous work estimated the potential technical benefit (i.e., peak reduction) of smart appliances, while this report focuses on the monetary value of that participation. The effects on wholesale energy cost and possible additional revenue available by participating in frequency regulation and spinning reserve markets were explored.

  7. Quality factor tuning of high-frequency high-Q filter biquads using adaptive signal processing

    E-Print Network [OSTI]

    Stevenson, Jan-Michael

    1997-01-01T23:59:59.000Z

    in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE Approved as to style and content by: D dgar Sanchez-Sinencio ( ir o Committee) I se Pineda Gyvez ember) Sherif H. K. Embabi (Member) er C. Jenkins (Member) C anan K... University Chair of Advisory Committee: Dr. Edgar Sanchez-Sinencio A quality factor (Q) tuning technique for high-frequency and high-Q continuous- time filter biquads is proposed. The method is based on the existing magnitude locked loop Q...

  8. Positive Feedback Regulation Results in Spatial Clustering and Fast Spreading of Active Signaling Molecules on a Cell Membrane

    E-Print Network [OSTI]

    Jayajit Das; Mehran Kardar; Arup K. Chakraborty

    2009-06-29T23:59:59.000Z

    Positive feedback regulation is ubiquitous in cell signaling networks, often leading to binary outcomes in response to graded stimuli. However, the role of such feedbacks in clustering, and in spatial spreading of activated molecules, has come to be appreciated only recently. We focus on the latter, using a simple model developed in the context of Ras activation with competing negative and positive feedback mechanisms. We find that positive feedback, in the presence of slow diffusion, results in clustering of activated molecules on the plasma membrane, and rapid spatial spreading as the front of the cluster propagates with a constant velocity (dependent on the feedback strength). The advancing fronts of the clusters of the activated species are rough, with scaling consistent with the Kardar-Parisi-Zhang (KPZ) equation in one dimension. Our minimal model is general enough to describe signal transduction in a wide variety of biological networks where activity in the membrane-proximal region is subject to feedback regulation.

  9. An Off-Chip Capacitor Free Low Dropout Regulator with PSR Enhancement at Higher Frequencies

    E-Print Network [OSTI]

    Gopalraju, Seenu

    2012-02-14T23:59:59.000Z

    of the requirements for the degree of MASTER OF SCIENCE Approved by: Chair of Committee, Edgar Sanchez-Sinencio Committee Members, Kamran Entesari Shankar P. Bhattacharyya Duncan Henry M. Walker Head of Department, Costas Georghiades December 2010... Sanchez-Sinencio Low Dropout Regulators (LDOs) are extensively used in portable applications like mobile phones, PDAs and notebooks. These portable applications demand high power efficiency and low output voltage ripple. In addition to these...

  10. Grid regulation services for energy storage devices based on grid frequency

    DOE Patents [OSTI]

    Pratt, Richard M; Hammerstrom, Donald J; Kintner-Meyer, Michael C.W.; Tuffner, Francis K

    2013-07-02T23:59:59.000Z

    Disclosed herein are representative embodiments of methods, apparatus, and systems for charging and discharging an energy storage device connected to an electrical power distribution system. In one exemplary embodiment, a controller monitors electrical characteristics of an electrical power distribution system and provides an output to a bi-directional charger causing the charger to charge or discharge an energy storage device (e.g., a battery in a plug-in hybrid electric vehicle (PHEV)). The controller can help stabilize the electrical power distribution system by increasing the charging rate when there is excess power in the electrical power distribution system (e.g., when the frequency of an AC power grid exceeds an average value), or by discharging power from the energy storage device to stabilize the grid when there is a shortage of power in the electrical power distribution system (e.g., when the frequency of an AC power grid is below an average value).

  11. Grid regulation services for energy storage devices based on grid frequency

    DOE Patents [OSTI]

    Pratt, Richard M; Hammerstrom, Donald J; Kintner-Meyer, Michael C.W.; Tuffner, Francis K

    2014-04-15T23:59:59.000Z

    Disclosed herein are representative embodiments of methods, apparatus, and systems for charging and discharging an energy storage device connected to an electrical power distribution system. In one exemplary embodiment, a controller monitors electrical characteristics of an electrical power distribution system and provides an output to a bi-directional charger causing the charger to charge or discharge an energy storage device (e.g., a battery in a plug-in hybrid electric vehicle (PHEV)). The controller can help stabilize the electrical power distribution system by increasing the charging rate when there is excess power in the electrical power distribution system (e.g., when the frequency of an AC power grid exceeds an average value), or by discharging power from the energy storage device to stabilize the grid when there is a shortage of power in the electrical power distribution system (e.g., when the frequency of an AC power grid is below an average value).

  12. Regulation and function of the Rho GTPase mediated signaling pathways in metastasis and lenticular differentiation

    E-Print Network [OSTI]

    Mitchell, Dianne Courtenay

    2007-09-17T23:59:59.000Z

    of the Rho family of small GTPases. The loss of KiSS-1 that commonly occurs during metastatic progression, leads to a loss of proper Rho GTPase regulation. This study has examined how KiSS-1 is regulated in two tissue types, breast and skin, and how the loss...

  13. Estradiol-Induced Object Memory Consolidation in Middle-Aged Female Mice Requires Dorsal Hippocampal Extracellular Signal-Regulated Kinase and Phosphatidylinositol 3-Kinase Activation

    E-Print Network [OSTI]

    Lewis, Michael C.

    We previously demonstrated that dorsal hippocampal extracellular signal-regulated kinase (ERK) activation is necessary for 17?[beta]-estradiol (E2[E subscript 2]) to enhance novel object recognition in young ovariectomized ...

  14. Regulation of horizontal gene transfer by intercellular peptide signaling in Bacillus subtilis

    E-Print Network [OSTI]

    Auchtung, Jennifer M

    2006-01-01T23:59:59.000Z

    Horizontal gene transfer plays an important role in bacterial evolution. Although acquisition of foreign DNA can be beneficial to cells, it can also be detrimental. Therefore, cells that possess mechanisms to regulate ...

  15. Insights into the regulation of mTOR signaling and the consequences of pharmacological inhibition

    E-Print Network [OSTI]

    Thoreen, Carson Cornell

    2008-01-01T23:59:59.000Z

    Cells have evolved a highly tuned system for driving growth in response to the right cues. Permissive signals initiate a cascade of events that send nutrient transporters to the membrane, suppress apoptosis, boost protein ...

  16. Dmp1 Regulates Osteocyte Function Via Wnt/?-Catenin Signaling Pathway 

    E-Print Network [OSTI]

    Lin, Shuxian

    2014-05-06T23:59:59.000Z

    , both theories appear controversy. Besides, the mechanism by which ARHR patients or Dmp1- null mice develop osteomalacia is largely unknown. In this study, we initially targeted DMP1 either in the nucleus only by replacing the endogenous signal peptide...

  17. Negative Self-Regulation of TLR9 Signaling by Its N-Terminal Proteolytic Cleavage Product

    E-Print Network [OSTI]

    Ploegh, Hidde

    TLR signaling is essential to innate immunity against microbial invaders and must be tightly controlled. We have previously shown that TLR9 undergoes proteolytic cleavage processing by lysosomal proteases to generate two ...

  18. Extracellular signal-regulated kinase 2 (ERK-2) mediated phosphorylation regulates nucleo-cytoplasmic shuttling and cell growth control of Ras-associated tumor suppressor protein, RASSF2

    SciTech Connect (OSTI)

    Kumari, Gita [Laboratory of Molecular Virology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500076 (India)] [Laboratory of Molecular Virology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500076 (India); Mahalingam, S., E-mail: mahalingam@iitm.ac.in [Laboratory of Molecular Virology, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500076 (India); Department of Biotechnology, Laboratory of Molecular Virology and Cell Biology, Indian Institute of Technology-Madras, Chennai 600 036 (India)

    2009-10-01T23:59:59.000Z

    Ras GTPase controls the normal cell growth through binding with an array of effector molecules, such as Raf and PI3-kinase in a GTP-dependent manner. RASSF2, a member of the Ras association domain family, is known to be involved in the suppression of cell growth and is frequently down-regulated in various tumor tissues by promoter hypermethylation. In the present study, we demonstrate that RASSF2 shuttles between nucleus and cytoplasm by a signal-mediated process and its export from the nucleus is sensitive to leptomycin B. Amino acids between 240 to 260 in the C-terminus of RASSF2 harbor a functional nuclear export signal (NES), which is necessary and sufficient for efficient export of RASSF2 from the nucleus. Substitution of conserved Ile254, Val257 and Leu259 within the minimal NES impaired RASSF2 export from the nucleus. In addition, wild type but not the nuclear export defective RASSF2 mutant interacts with export receptor, CRM-1 and exported from the nucleus. Surprisingly, we observed nucleolar localization for the nuclear export defective mutant suggesting the possibility that RASSF2 may localize in different cellular compartments transiently in a cell cycle dependent manner and the observed nuclear localization for wild type protein may be due to faster export kinetics from the nucleolus. Furthermore, our data suggest that RASSF2 is specifically phosphorylated by MAPK/ERK-2 and the inhibitors of MAPK pathway impair the phosphorylation and subsequently block the export of RASSF2 from the nucleus. These data clearly suggest that ERK-2 mediated phosphorylation plays an important role in regulating the nucleo-cytoplasmic shuttling of RASSF2. Interestingly, nuclear import defective mutant of RASSF2 failed to induce cell cycle arrest at G1/S phase and apoptosis suggesting that RASSF2 regulates cell growth in a nuclear localization dependent manner. Collectively, these data provided evidence for the first time that MAPK/ERK-2 mediated phosphorylation regulates nucleo-cytoplasmic transport and cell growth arrest activity of RASSF2. Taken together, the present study suggests that active transport between nucleus and cytoplasm may constitute an important regulatory mechanism for RASSF2 function.

  19. Automatic system for regulating the frequency and power of the 500 MW coal-dust power generating units at the Reftinskaya GRES

    SciTech Connect (OSTI)

    Bilenko, V. A.; Gal'perina, A. I.; Mikushevich, E. E.; Nikol'skii, D. Yu. [JSC 'Interavtomatka' (Russian Federation); Zhugrin, A. G.; Bebenin, P. A.; Syrchin, M. V. [JSC 'Reftinskaya GRES' (Russian Federation)

    2009-03-15T23:59:59.000Z

    The monitoring and control systems at the 500 MW coal-dust power generating units No. 7, 8, and 9 at the Reftinskaya GRES have been modernized using information-regulator systems. Layouts for instrumental construction of these systems and expanded algorithmic schemes for the automatic frequency and power control system and for the boiler supply and fuelling are discussed. Results from tests and normal operation of the automatic frequency and power control system are presented.

  20. Effect on the condition of the metal in A K-300-3.5 turbine owing to multicycle fatigue from participation of a power generating unit in grid frequency and power regulation

    SciTech Connect (OSTI)

    Lebedeva, A. I.; Zorchenko, N. V.; Prudnikov, A. A.

    2011-09-15T23:59:59.000Z

    The effect on the condition of the rotor material owing to multicycle fatigue caused by variable stresses during participation of a power generating unit in grid frequency and power regulation is evaluated using the K-300-23.5 steam turbine as an example. It is shown that during normalized primary frequency regulation the safety factor is at least 50, while during automatic secondary regulation of frequency and power there is essentially no damage to the metal.

  1. Apparatus and method for detecting and measuring changes in linear relationships between a number of high frequency signals

    DOE Patents [OSTI]

    Bittner, John W. (Shoreham, NY); Biscardi, Richard W. (Ridge, NY)

    1991-01-01T23:59:59.000Z

    An electronic measurement circuit for high speed comparison of the relative amplitudes of a predetermined number of electrical input signals independent of variations in the magnitude of the sum of the signals. The circuit includes a high speed electronic switch that is operably connected to receive on its respective input terminals one of said electrical input signals and to have its common terminal serve as an input for a variable-gain amplifier-detector circuit that is operably connected to feed its output to a common terminal of a second high speed electronic switch. The respective terminals of the second high speed electronic switch are operably connected to a plurality of integrating sample and hold circuits, which in turn have their outputs connected to a summing logic circuit that is operable to develop first, second and third output voltages, the first output voltage being proportional to a predetermined ratio of sums and differences between the compared input signals, the second output voltage being proportional to a second summed ratio of predetermined sums and differences between said input signals, and the third output voltage being proportional to the sum of signals to the summing logic circuit. A servo system that is operably connected to receive said third output signal and compare it with a reference voltage to develop a slowly varying feedback voltage to control the variable-gain amplifier in said common amplifier-detector circuit in order to make said first and second output signals independent of variations in the magnitude of the sum of said input signals.

  2. Apparatus and method for detecting and measuring changes in linear relationships between a number of high frequency signals

    DOE Patents [OSTI]

    Bittner, J.W.; Biscardi, R.W.

    1991-03-19T23:59:59.000Z

    An electronic measurement circuit is disclosed for high speed comparison of the relative amplitudes of a predetermined number of electrical input signals independent of variations in the magnitude of the sum of the signals. The circuit includes a high speed electronic switch that is operably connected to receive on its respective input terminals one of said electrical input signals and to have its common terminal serve as an input for a variable-gain amplifier-detector circuit that is operably connected to feed its output to a common terminal of a second high speed electronic switch. The respective terminals of the second high speed electronic switch are operably connected to a plurality of integrating sample and hold circuits, which in turn have their outputs connected to a summing logic circuit that is operable to develop first, second and third output voltages, the first output voltage being proportional to a predetermined ratio of sums and differences between the compared input signals, the second output voltage being proportional to a second summed ratio of predetermined sums and differences between said input signals, and the third output voltage being proportional to the sum of signals to the summing logic circuit. A servo system that is operably connected to receive said third output signal and compare it with a reference voltage to develop a slowly varying feedback voltage to control the variable-gain amplifier in said common amplifier-detector circuit in order to make said first and second output signals independent of variations in the magnitude of the sum of said input signals. 2 figures.

  3. INDEPENDENT SIGNALS FROM THE INFLUENCE OF INTERNAL MAGNETIC LAYERS ON THE FREQUENCIES OF SOLAR p-MODES

    SciTech Connect (OSTI)

    Foullon, C.; Nakariakov, V. M. [Centre for Fusion, Space and Astrophysics, Department of Physics, University of Warwick, Coventry CV4 7AL (United Kingdom)], E-mail: claire.foullon@warwick.ac.uk

    2010-05-01T23:59:59.000Z

    The discovery that p-mode frequencies of low degree do not follow changes of solar surface activity during the recent solar minimum offers the possibility of a new diagnostic signature of the responsible pressure perturbation in the wave guiding medium, potentially rich of information regarding the structure of the Sun and the cause of the unusually long solar minimum. Magnetic fields, as well as temperature changes, introduce equilibrium pressure deviations that modify the resonant frequencies of p-mode oscillations. Assuming the perturbation to be caused by a horizontal layer of magnetic field located in a plane-stratified model of the Sun, we compile analytical frequency shifts and process them to allow direct comparison with observations. The effect of magnetism itself on the central p-mode frequencies can be neglected in comparison with the thermal effect of a perturbative layer buried in the solar interior. A parametric study shows that a layer as thin as 2100 km at subsurface depths is able to reproduce reported mean anomalous frequency shifts (not correlated with the surface activity), while a layer of size around 4200 km increasing by a small amount at depths near 0.08 R {sub sun} can explain individual low-degree shifts. It is also possible to obtain the mean shifts via the upward motion through depths near 0.03 R {sub sun} of a rising perturbative layer of thickness around 7000 km. Hence, the anomalous frequency shifts are best explained by thermal effects in the upper regions of the convection zone. The effects of latitudinal distribution are not treated here.

  4. Positive regulation of the Egr-1/osteopontin positive feedback loop in rat vascular smooth muscle cells by TGF-{beta}, ERK, JNK, and p38 MAPK signaling

    SciTech Connect (OSTI)

    Yu, Hong-Wei; Liu, Qi-Feng [Department of Cardiology, The First Affiliated Hospital of China Medical University, 155th North of Nanjing Street, Heping Block, Shenyang, 110001 Liaoning Province (China)] [Department of Cardiology, The First Affiliated Hospital of China Medical University, 155th North of Nanjing Street, Heping Block, Shenyang, 110001 Liaoning Province (China); Liu, Gui-Nan, E-mail: guinanliu@hotmail.com [Department of Cardiology, The First Affiliated Hospital of China Medical University, 155th North of Nanjing Street, Heping Block, Shenyang, 110001 Liaoning Province (China)] [Department of Cardiology, The First Affiliated Hospital of China Medical University, 155th North of Nanjing Street, Heping Block, Shenyang, 110001 Liaoning Province (China)

    2010-05-28T23:59:59.000Z

    Previous studies identified a positive feedback loop in rat vascular smooth muscle cells (VSMCs) in which early growth response factor-1 (Egr-1) binds to the osteopontin (OPN) promoter and upregulates OPN expression, and OPN upregulates Egr-1 expression via the extracellular signal-regulated protein kinase (ERK) signaling pathway. The current study examined whether transforming growth factor-{beta} (TGF-{beta}) activity contributes to Egr-1 binding to the OPN promoter, and whether other signaling pathways act downstream of OPN to regulate Egr-1 expression. ChIP assays using an anti-Egr-1 antibody showed that amplification of the OPN promoter sequence decreased in TGF-{beta} DNA enzyme-transfected VSMCs relative to control VSMCs. Treatment of VSMCs with PD98059 (ERK inhibitor), SP600125 (JNK inhibitor), or SB203580 (p38 MAPK inhibitor) significantly inhibited OPN-induced Egr-1 expression, and PD98059 treatment was associated with the most significant decrease in Egr-1 expression. OPN-stimulated VSMC cell migration was inhibited by SP600125 or SB203580, but not by PD98059. Furthermore, MTT assays showed that OPN-mediated cell proliferation was inhibited by PD98059, but not by SP600125 or SB203580. Taken together, the results of the current study show that Egr-1 binding to the OPN promoter is positively regulated by TGF-{beta}, and that the p38 MAPK, JNK, and ERK pathways are involved in OPN-mediated Egr-1 upregulation.

  5. Design & development fo a 20-MW flywheel-based frequency regulation power plant : a study for the DOE Energy Storage Systems program.

    SciTech Connect (OSTI)

    Rounds, Robert (Beacon Power, Tyngsboro, MA); Peek, Georgianne Huff

    2009-01-01T23:59:59.000Z

    This report describes the successful efforts of Beacon Power to design and develop a 20-MW frequency regulation power plant based solely on flywheels. Beacon's Smart Matrix (Flywheel) Systems regulation power plant, unlike coal or natural gas generators, will not burn fossil fuel or directly produce particulates or other air emissions and will have the ability to ramp up or down in a matter of seconds. The report describes how data from the scaled Beacon system, deployed in California and New York, proved that the flywheel-based systems provided faster responding regulation services in terms of cost-performance and environmental impact. Included in the report is a description of Beacon's design package for a generic, multi-MW flywheel-based regulation power plant that allows accurate bids from a design/build contractor and Beacon's recommendations for site requirements that would ensure the fastest possible construction. The paper concludes with a statement about Beacon's plans for a lower cost, modular-style substation based on the 20-MW design.

  6. Fibroblast growth factor-2 up-regulates the expression of nestin through the Ras–Raf–ERK–Sp1 signaling axis in C6 glioma cells

    SciTech Connect (OSTI)

    Chang, Kai-Wei [Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan (China)] [Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan (China); Huang, Yuan-Li [Department of Biotechnology, College of Health Science, Asia University, Taichung 413, Taiwan (China)] [Department of Biotechnology, College of Health Science, Asia University, Taichung 413, Taiwan (China); Wong, Zong-Ruei; Su, Peng-Han [Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan (China)] [Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan (China); Huang, Bu-Miin [Department of Cell Biology and Anatomy, National Cheng-Kung University, Tainan 701, Taiwan (China)] [Department of Cell Biology and Anatomy, National Cheng-Kung University, Tainan 701, Taiwan (China); Ju, Tsai-Kai [Instrumentation Center, National Taiwan University, Taipei 106, Taiwan (China) [Instrumentation Center, National Taiwan University, Taipei 106, Taiwan (China); Technology Commons, College of Life Science, National Taiwan University, Taipei 106, Taiwan (China); Yang, Hsi-Yuan, E-mail: hyhy@ntu.edu.tw [Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan (China)] [Institute of Molecular and Cellular Biology, National Taiwan University, Taipei 106, Taiwan (China)

    2013-05-17T23:59:59.000Z

    Highlights: •Nestin expression in C6 glioma cells is induced by FGF-2. •Nestin expression is induced by FGF-2 via de novo RNA and protein synthesis. •The FGFR inhibitor SU5402 blocks the FGF-2-induced nestin expression. •The mRNA of FGFR1 and 3 are detected in C6 glioma cells. •Ras–Raf–ERK–Sp1 signaling pathway is responsibe for FGF-2-induced nestin expression. -- Abstract: Nestin is a 240-kDa intermediate filament protein expressed mainly in neural and myogenic stem cells. Although a substantial number of studies have focused on the expression of nestin during development of the central nervous system, little is known about the factors that induce and regulate its expression. Fibroblast growth factor-2 (FGF-2) is an effective mitogen and stimulates the proliferation and differentiation of a subset of nestin-expressing cells, including neural progenitor cells, glial precursor cells, and smooth muscle cells. To assess whether FGF-2 is a potent factor that induces the expression of nestin, C6 glioma cells were used. The results showed that nestin expression was up-regulated by FGF-2 via de novo RNA and protein synthesis. Our RT-PCR results showed that C6 glioma cells express FGFR1/3, and FGFRs is required for FGF-2-induced nestin expression. Further signaling analysis also revealed that FGF-2-induced nestin expression is mediated through FGFR–MAPK–ERK signaling axis and the transcriptional factor Sp1. These findings provide new insight into the regulation of nestin in glial system and enable the further studies on the function of nestin in glial cells.

  7. Radio frequency detection assembly and method for detecting radio frequencies

    DOE Patents [OSTI]

    Cown, Steven H. (Rigby, ID); Derr, Kurt Warren (Idaho Falls, ID)

    2010-03-16T23:59:59.000Z

    A radio frequency detection assembly is described and which includes a radio frequency detector which detects a radio frequency emission produced by a radio frequency emitter from a given location which is remote relative to the radio frequency detector; a location assembly electrically coupled with the radio frequency detector and which is operable to estimate the location of the radio frequency emitter from the radio frequency emission which has been received; and a radio frequency transmitter electrically coupled with the radio frequency detector and the location assembly, and which transmits a radio frequency signal which reports the presence of the radio frequency emitter.

  8. Spatial Phosphoprotein Profiling Reveals a Compartmentalized Extracellular Signal-regulated Kinase Switch Governing Neurite Growth and Retraction

    SciTech Connect (OSTI)

    Wang, Yingchun; Yang, Feng; Fu, Yi; Huang, Xiahe; Wang, Wei; Jiang, Xining; Gritsenko, Marina A.; Zhao, Rui; Monroe, Matthew E.; Pertz, Olivier C.; Purvine, Samuel O.; Orton, Daniel J.; Jacobs, Jon M.; Camp, David G.; Smith, Richard D.; Klemke, Richard L.

    2011-05-20T23:59:59.000Z

    Abstract - Brain development and spinal cord regeneration require neurite sprouting and growth cone navigation in response to extension and collapsing factors present in the extracellular environment. These external guidance cues control neurite growth cone extension and retraction processes through intracellular protein phosphorylation of numerous cytoskeletal, adhesion, and polarity complex signaling proteins. However, the complex kinase/substrate signaling networks that mediate neuritogenesis have not been investigated. Here, we compare the neurite phosphoproteome under growth and retraction conditions using neurite purification methodology combined with mass spectrometry. More than 4000 non-redundant phosphorylation sites from 1883 proteins have been annotated and mapped to signaling pathways that control kinase/phosphatase networks, cytoskeleton remodeling, and axon/dendrite specification. Comprehensive informatics and functional studies revealed a compartmentalized ERK activation/deactivation cytoskeletal switch that governs neurite growth and retraction, respectively. Our findings provide the first system-wide analysis of the phosphoprotein signaling networks that enable neurite growth and retraction and reveal an important molecular switch that governs neuritogenesis.

  9. Multi-frequency communication system and method

    DOE Patents [OSTI]

    Carrender, Curtis Lee; Gilbert, Ronald W.

    2004-06-01T23:59:59.000Z

    A multi-frequency RFID remote communication system is provided that includes a plurality of RFID tags configured to receive a first signal and to return a second signal, the second signal having a first frequency component and a second frequency component, the second frequency component including data unique to each remote RFID tag. The system further includes a reader configured to transmit an interrogation signal and to receive remote signals from the tags. A first signal processor, preferably a mixer, removes an intermediate frequency component from the received signal, and a second processor, preferably a second mixer, analyzes the IF frequency component to output data that is unique to each remote tag.

  10. AP-1 regulates {alpha}{sub 2}{beta}{sub 1} integrin expression by ERK-dependent signals during megakaryocytic differentiation of K562 cells

    SciTech Connect (OSTI)

    Eriksson, Minna [Molecular Cancer Biology Research Program, Biomedicum Helsinki and Haartman Institute, P.O. Box 63, FIN-00014 Helsinki (Finland); Department of Oncology, Helsinki University Central Hospital, P.O. Box 180, FIN-00029 HUCH (Finland); Arminen, Laura [Molecular Cancer Biology Research Program, Biomedicum Helsinki and Haartman Institute, P.O. Box 63, FIN-00014 Helsinki (Finland); Department of Oncology, Helsinki University Central Hospital, P.O. Box 180, FIN-00029 HUCH (Finland); Karjalainen-Lindsberg, Marja-Liisa [University of Helsinki, P.O. Box 63, FIN-00014 Helsinki (Finland); Leppae, Sirpa [Molecular Cancer Biology Research Program, Biomedicum Helsinki and Haartman Institute, P.O. Box 63, FIN-00014 Helsinki (Finland) and Department of Oncology, Helsinki University Central Hospital, P.O. Box 180, FIN-00029 HUCH (Finland)]. E-mail: sirpa.leppa@hus.fi

    2005-03-10T23:59:59.000Z

    Mitogen-activated protein kinases (MAPKs) have been implicated as regulators of cellular differentiation. The biological effect of MAPK signaling in the nucleus is achieved by signal-responsive transcription factors. Here, we have investigated the connection of MAPKs, transcription factor AP-1, and {alpha}{sub 2}{beta}{sub 1} integrin expression in K562 cells undergoing differentiation along the megakaryocytic pathway. We report that three distinct MAPKs, ERK, JNK, and p38, are activated during the TPA-induced megakaryocytic differentiation. Activation of MAPK pathways is followed by acquisition of the AP-1 DNA-binding and transactivation capacities. AP-1 DNA-binding activity consists primarily of JunD, c-Fos, and Fra-1, and is accompanied with the increased expression and phosphorylation of these subunits. While inhibition of JNK mainly prevents expression and phosphorylation of JunD and c-Jun, inhibition of the ERK pathway suppresses both phosphorylation and expression of Jun proteins, and expression of c-Fos and Fra-1. Furthermore, only the activity of the ERK pathway is essential for the differentiation response, as determined by expression of {alpha}{sub 2}{beta}{sub 1} (CD49b) integrin. The importance of AP-1 as a mediator ERK signaling during differentiation is demonstrated by the findings that expression of c-fos siRNA and dominant negative AP-1/c-Jun{sup bZIP} downregulate the TPA- and ERK-induced expression of {alpha}{sub 2}{beta}{sub 1} integrin mRNAs and proteins. Conversely, coexpression of JunD or c-Jun and c-Fos can induce {alpha}{sub 2}{beta}{sub 1} integrin expression independently of upstream signals. Taken together, the results show that AP-1 is a nuclear target of the ERK-pathway and mediates {alpha}{sub 2}{beta}{sub 1} integrin expression during megakaryocytic differentiation of K562 cells.

  11. Erlotinib inhibits T-cell-mediated immune response via down-regulation of the c-Raf/ERK cascade and Akt signaling pathway

    SciTech Connect (OSTI)

    Luo Qiong [State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University 22 Han Kou Road, Nanjing 210093 (China); Gu Yanhong [Department of Clinical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029 (China); Zheng Wei; Wu Xingxin; Gong Fangyuan; Gu Liyun; Sun Yang [State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University 22 Han Kou Road, Nanjing 210093 (China); Xu Qiang, E-mail: molpharm@163.com [State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University 22 Han Kou Road, Nanjing 210093 (China)

    2011-03-01T23:59:59.000Z

    Erlotinib is a potent inhibitor of epidermal growth factor receptor tyrosine kinase and has been demonstrated to treat advanced or metastatic non-small cell lung cancer to prolong survival after failure of first-line or second-line chemotherapy. However, little is known about its effects on immune system. In the present study, we aimed to investigate the immunosuppressive activity of erlotinib on T lymphocytes both in vitro and in vivo, and further explore its potential molecular mechanism. Erlotinib exerted a significant inhibition on the T cell proliferation and activation induced by concanavalin A, anti-CD3 plus anti-CD28, staphylococcal enterotoxin B or phorbol myristate acetate respectively in a concentration-dependent manner and it also inhibited the secretion of the proinflammatory cytokines such as IL-2 and IFN-{gamma} of activated T cells. Further study showed that erlotinib caused G0/G1 arrest and suppressed the phosphorylations of c-Raf, ERK and Akt in activated T cells. Moreover, erlotinib significantly ameliorated picryl chloride-induced ear contact dermatitis in a dose-dependent manner in vivo. In summary, these findings suggest that erlotinib may cause the impairment of T-cell-mediated immune response both in vitro and in vivo through inhibiting T cell proliferation and activation, which is closely associated with its potent down-regulation of the c-Raf/ERK cascade and Akt signaling pathway. - Graphical abstract: Erlotinib may cause the impairment of T-cell-mediated immune response both in vitro and in vivo through inhibiting T cell proliferation and activation, which is closely associated with its potent down-regulation of the c-Raf/ERK cascade and Akt signaling pathway. Display Omitted

  12. Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signaling

    SciTech Connect (OSTI)

    Mathew, Jasmin; Loranger, Anne; Gilbert, Stéphane [Centre de recherche en cancérologie de l'Université Laval and Centre de recherche du CHUQ (L'Hôtel-Dieu de Québec), 9 McMahon, Québec, Qc, Canada G1R 2J6 (Canada); Faure, Robert [Département de Pédiatrie, Université Laval and Centre de recherche du CHUQ (Centre Mère-Enfant), Québec, Qc, Canada G1V 4G2 (Canada); Marceau, Normand, E-mail: normand.marceau@crhdq.ulaval.ca [Centre de recherche en cancérologie de l'Université Laval and Centre de recherche du CHUQ (L'Hôtel-Dieu de Québec), 9 McMahon, Québec, Qc, Canada G1R 2J6 (Canada)

    2013-02-15T23:59:59.000Z

    As differentiated cells, hepatocytes primarily metabolize glucose for ATP production through oxidative phosphorylation of glycolytic pyruvate, whereas proliferative hepatocellular carcinoma (HCC) cells undergo a metabolic shift to aerobic glycolysis despite oxygen availability. Keratins, the intermediate filament (IF) proteins of epithelial cells, are expressed as pairs in a lineage/differentiation manner. Hepatocyte and HCC (hepatoma) cell IFs are made solely of keratins 8/18 (K8/K18), thus providing models of choice to address K8/K18 IF functions in normal and cancerous epithelial cells. Here, we demonstrate distinctive increases in glucose uptake, glucose-6-phosphate formation, lactate release, and glycogen formation in K8/K18 IF-lacking hepatocytes and/or hepatoma cells versus their respective IF-containing counterparts. We also show that the K8/K18-dependent glucose uptake/G6P formation is linked to alterations in hexokinase I/II/IV content and localization at mitochondria, with little effect on GLUT1 status. In addition, we find that the insulin-stimulated glycogen formation in normal hepatocytes involves the main PI-3 kinase-dependent signaling pathway and that the K8/K18 IF loss makes them more efficient glycogen producers. In comparison, the higher insulin-dependent glycogen formation in K8/K18 IF-lacking hepatoma cells is associated with a signaling occurring through a mTOR-dependent pathway, along with an augmentation in cell proliferative activity. Together, the results uncover a key K8/K18 regulation of glucose metabolism in normal and cancerous hepatic cells through differential modulations of mitochondrial HK status and insulin-mediated signaling.

  13. Lactoferrin inhibits dexamethasone-induced chondrocyte impairment from osteoarthritic cartilage through up-regulation of extracellular signal-regulated kinase 1/2 and suppression of FASL, FAS, and Caspase 3

    SciTech Connect (OSTI)

    Tu, Yihui [Department of Orthopaedics, Yangpu District Central Hospital Affiliated to Tongji University School of Medicine, 450 Tengyue Road, Shanghai (China)] [Department of Orthopaedics, Yangpu District Central Hospital Affiliated to Tongji University School of Medicine, 450 Tengyue Road, Shanghai (China); Xue, Huaming [Department of Orthopaedics, Yangpu District Central Hospital Affiliated to Tongji University School of Medicine, 450 Tengyue Road, Shanghai (China) [Department of Orthopaedics, Yangpu District Central Hospital Affiliated to Tongji University School of Medicine, 450 Tengyue Road, Shanghai (China); Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom); Francis, Wendy [Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom)] [Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom); Davies, Andrew P. [Department of Orthopaedics and Trauma, Moriston Hospital, Swansea (United Kingdom)] [Department of Orthopaedics and Trauma, Moriston Hospital, Swansea (United Kingdom); Pallister, Ian; Kanamarlapudi, Venkateswarlu [Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom)] [Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom); Xia, Zhidao, E-mail: zhidao.xia@gmail.com [Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom)] [Institute of Life Science, College of Medicine, Swansea University, Singleton Park (United Kingdom)

    2013-11-08T23:59:59.000Z

    Highlights: •Dex exerts dose-dependant inhibition of HACs viability and induction of apoptosis. •Dex-induced impairment of chondrocytes was attenuated by rhLF. •ERK and FASL/FAS signaling are involved in the effects of rhLF. •OA patients with glucocorticoid-induced cartilage damage may benefit from treatment with rhLF. -- Abstract: Dexamethasone (Dex) is commonly used for osteoarthritis (OA) with excellent anti-inflammatory and analgesic effect. However, Dex also has many side effects following repeated use over prolonged periods mainly through increasing apoptosis and inhibiting proliferation. Lactoferrin (LF) exerts significantly anabolic effect on many cells and little is known about its effect on OA chondrocytes. Therefore, the aim of this study is to investigate whether LF can inhibit Dex-induced OA chondrocytes apoptosis and explore its possible molecular mechanism involved in. MTT assay was used to determine the optimal concentration of Dex and recombinant human LF (rhLF) on chondrocytes at different time and dose points. Chondrocytes were then stimulated with Dex in the absence or presence of optimal concentration of rhLF. Cell proliferation and viability were evaluated using MTT and LIVE/DEAD assay, respectively. Cell apoptosis was evaluated by multi-parameter apoptosis assay kit using both confocal microscopy and flow cytometry, respectively. The expression of extracellular signal-regulated kinase (ERK), FAS, FASL, and Caspase-3 (CASP3) at the mRNA and protein levels were examined by real-time polymerase chain reaction (PCR) and immunocytochemistry, respectively. The optimal concentration of Dex (25 ?g/ml) and rhLF (200 ?g/ml) were chosen for the following experiments. rhLF significantly reversed the detrimental effect of Dex on chondrocytes proliferation, viability, and apoptosis. In addition, rhLF significantly prevented Dex-induced down-regulation of ERK and up-regulation of FAS, FASL, and CASP3. These findings demonstrated that rhLF acts as an anabolic effect on chondrocytes through significantly reversing Dex-induced chondrocytes apoptosis. This study may contribute to further investigating the clinical application of LF on OA.

  14. Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and ?-catenin signaling pathway

    SciTech Connect (OSTI)

    Li, Hongzhong; Huang, Jing; Yang, Bing; Xiang, Tingxiu; Yin, Xuedong; Peng, Weiyan; Cheng, Wei [Molecular Oncology and Epigenetics Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing (China); Wan, Jingyuan; Luo, Fuling [Department of Pharmacology, Chongqing Medical University, Chongqing (China); Li, Hongyuan [Molecular Oncology and Epigenetics Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing (China); Ren, Guosheng, E-mail: rgs726@163.com [Molecular Oncology and Epigenetics Laboratory, The First Affiliated Hospital of Chongqing Medical University, Chongqing (China)

    2013-10-01T23:59:59.000Z

    Although mangiferin which is a naturally occurring glucosylxanthone has exhibited promising anticancer activities, the detailed molecular mechanism of mangiferin on cancers still remains enigmatic. In this study, the anticancer activity of mangiferin was evaluated in breast cancer cell line-based in vitro and in vivo models. We showed that mangiferin treatment resulted in decreased cell viability and suppression of metastatic potential in breast cancer cells. Further mechanistic investigation revealed that mangiferin induced decreased matrix metalloproteinase (MMP)-7 and -9, and reversal of epithelial–mesenchymal transition (EMT). Moreover, it was demonstrated that mangiferin significantly inhibited the activation of ?-catenin pathway. Subsequent experiments showed that inhibiting ?-catenin pathway might play a central role in mangiferin-induced anticancer activity through modulation of MMP-7 and -9, and EMT. Consistent with these findings in vitro, the antitumor potential was also verified in mangiferin-treated MDA-MB-231 xenograft mice where significantly decreased tumor volume, weight and proliferation, and increased apoptosis were obtained, with lower expression of MMP-7 and -9, vimentin and active ?-catenin, and higher expression of E-cadherin. Taken together, our study suggests that mangiferin might be used as an effective chemopreventive agent against breast cancer. - Highlights: • Mangiferin inhibits growth and metastatic potential in breast cancer cells. • Mangiferin down-regulates MMP-7 and -9 in breast cancer cells. • Mangiferin induces the reversal of EMT in metastatic breast cancer cells. • Mangiferin inhibits the activation of ?-catenin pathway in breast cancer cells. • Inhibiting ?-catenin is responsible for the antitumor activity of mangiferin.

  15. A Critical Role of the PTEN/PDGF Signaling Network for the Regulation of Radiosensitivity in Adenocarcinoma of the Prostate

    SciTech Connect (OSTI)

    Christensen, Michael, E-mail: mechristense@uwalumni.com [Department of Radiation Oncology, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Center, Detroit, Michigan (United States); Najy, Abdo J. [Department of Pathology, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Center, Detroit, Michigan (United States); Snyder, Michael; Movilla, Lisa S. [Department of Radiation Oncology, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Center, Detroit, Michigan (United States); Kim, Hyeong-Reh Choi [Department of Pathology, Wayne State University School of Medicine, Barbara Ann Karmanos Cancer Center, Detroit, Michigan (United States)

    2014-01-01T23:59:59.000Z

    Purpose: Loss or mutation of the phosphate and tensin homologue (PTEN) is a common genetic abnormality in prostate cancer (PCa) and induces platelet-derived growth factor D (PDGF D) signaling. We examined the role of the PTEN/PDGF axis on radioresponse using a murine PTEN null prostate epithelial cell model. Methods and Materials: PTEN wild-type (PTEN{sup +/+}) and PTEN knockout (PTEN{sup ?/?}) murine prostate epithelial cell lines were used to examine the relationship between the PTEN status and radiosensitivity and also to modulate the PDGF D expression levels. PTEN{sup ?/?} cells were transduced with a small hairpin RNA (shRNA) lentiviral vector containing either scrambled nucleotides (SCRM) or sequences targeted to PDGF D (shPDGF D). Tumorigenesis and morphogenesis of these cell lines were evaluated in vivo via subcutaneous injection of male nude mice and in vitro using Matrigel 3-dimensional (3D) culture. Effects of irradiation on clonogenic survival, cell migration, and invasion were measured with respect to the PTEN status and the PDGF D expression level. In addition, apoptosis and cell cycle redistribution were examined as potential mechanisms for differences seen. Results: PTEN{sup ?/?} cells were highly tumorigenic in animals and effectively formed foci in 3D culture. Importantly, loss of PDGF D in these cell lines drastically diminished these phenotypes. Furthermore, PTEN{sup ?/?} cells demonstrated increased clonogenic survival in vitro compared to PTEN{sup +/+}, and attenuation of PDGF D significantly reversed this radioresistant phenotype. PTEN{sup ?/?} cells displayed greater migratory and invasive potential at baseline as well as after irradiation. Both the basal and radiation-induced migratory and invasive phenotypes in PTEN{sup ?/?} cells required PDGF D expression. Interestingly, these differences were independent of apoptosis and cell cycle redistribution, as they showed no significant difference. Conclusions: We propose that PDGF D represents a potentially promising target for PCa treatment resistance in the absence of PTEN function, and warrants further laboratory evaluation and clinical study.

  16. Graphene Frequency Multipliers

    E-Print Network [OSTI]

    Wang, Han

    In this letter, the ambipolar transport properties of graphene flakes have been used to fabricate full-wave signal rectifiers and frequency-doubling devices. By correctly biasing an ambipolar graphene field-effect transistor ...

  17. Phosphoproteomic approaches to elucidate cellular signaling networks

    E-Print Network [OSTI]

    White Protein phosphorylation is crucial in the regulation of signaling pathways that control various measurements, computational modeling and biochemical manipulations, will ultimately reveal the mechanistic regulation of signaling networks. Addresses Biological Engineering Division, Massachusetts Institute

  18. Regulation in EAE Costimulatory Signals

    E-Print Network [OSTI]

    Shihadeh, Alan

    1 10 100 0 50 100 150 200 0 1 10 100 CD28KO C57BL/6 WT IFN-gpg/ml IFN-gProducingCells MOG peptide 1 10 100 *p=0.0009 **p=0.009 MOG peptide concentration IFN-gpg/ml IFN-gProducingCells CD28KO C57BL/6

  19. A newsletter for non-scientists (and scientists) interested in MAGIC Radars transmit pulses of radio waves of a given frequency and receive signals that are

    E-Print Network [OSTI]

    the Doppler effect, named after Christian Doppler, an Austrian physicist of the 19th century. Everyone sizes of raindrops. The Doppler effect pertains to the change in frequency of a wave emitted-- this is the Doppler effect in a nutshell. The amount by which the pitch is greater or lower, called the Doppler shift

  20. Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3{beta}

    SciTech Connect (OSTI)

    Choi, Cheol-Hee [Research Center for Resistant Cells, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759 (Korea, Republic of) [Research Center for Resistant Cells, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759 (Korea, Republic of); Department of Pharmacology, College of Medicine, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759 (Korea, Republic of); Lee, Byung-Hoon [College of Pharmacy and Multiscreening Center for Drug Development, Seoul National University, Seoul 151-742 (Korea, Republic of)] [College of Pharmacy and Multiscreening Center for Drug Development, Seoul National University, Seoul 151-742 (Korea, Republic of); Ahn, Sang-Gun [Department of Pathology, College of Dentistry, Chosun University, Gwangju 501-759 (Korea, Republic of)] [Department of Pathology, College of Dentistry, Chosun University, Gwangju 501-759 (Korea, Republic of); Oh, Seon-Hee, E-mail: oshccw@hanmail.net [Research Center for Resistant Cells, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759 (Korea, Republic of)] [Research Center for Resistant Cells, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759 (Korea, Republic of)

    2012-02-24T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer MG132 induces the phosphorylation of GSK3{beta}{sup Ser9} and, to a lesser extent, of GSK3{beta}{sup Thr390}. Black-Right-Pointing-Pointer MG132 induces dephosphorylation of p70S6K{sup Thr389} and phosphorylation of p70S6K{sup Thr421/Ser424}. Black-Right-Pointing-Pointer Inactivation of p38 dephosphorylates GSK3{beta}{sup Ser9} and phosphorylates GSK3{beta}{sup Thr390}. Black-Right-Pointing-Pointer Inactivation of p38 phosphorylates p70S6K{sup Thr389} and increases the phosphorylation of p70S6K{sup Thr421/Ser424}. Black-Right-Pointing-Pointer Inactivation of p38 decreases autophagy and increases apoptosis induced by MG132. -- Abstract: Proteasome inhibition is a promising approach for cancer treatment; however, the underlying mechanisms involved have not been fully elucidated. Here, we show that proteasome inhibition-induced p38 mitogen-activated protein kinase regulates autophagy and apoptosis by modulating the phosphorylation status of glycogen synthase kinase 3{beta} (GSK3{beta}) and 70 kDa ribosomal S6 kinase (p70S6K). The treatment of MDA-MB-231 cells with MG132 induced endoplasmic reticulum stress through the induction of ATF6a, PERK phosphorylation, and CHOP, and apoptosis through the cleavage of Bax and procaspase-3. MG132 caused the phosphorylation of GSK3{beta} at Ser{sup 9} and, to a lesser extent, Thr{sup 390}, the dephosphorylation of p70S6K at Thr{sup 389}, and the phosphorylation of p70S6K at Thr{sup 421} and Ser{sup 424}. The specific p38 inhibitor SB203080 reduced the p-GSK3{beta}{sup Ser9} and autophagy through the phosphorylation of p70S6K{sup Thr389}; however, it augmented the levels of p-ERK, p-GSK3{beta}{sup Thr390}, and p-70S6K{sup Thr421/Ser424} induced by MG132, and increased apoptotic cell death. The GSK inhibitor SB216763, but not lithium, inhibited the MG132-induced phosphorylation of p38, and the downstream signaling pathway was consistent with that in SB203580-treated cells. Taken together, our data show that proteasome inhibition regulates p38/GSK{sup Ser9}/p70S6K{sup Thr380} and ERK/GSK3{beta}{sup Thr390}/p70S6K{sup Thr421/Ser424} kinase signaling, which is involved in cell survival and cell death.

  1. Method and apparatus for monitoring the rotating frequency of de-energized induction motors

    DOE Patents [OSTI]

    Mikesell, Harvey E. (McMurray, PA); Lucy, Eric (Murrysville, PA)

    1998-01-01T23:59:59.000Z

    The rotational speed of a coasting induction motor is measured by sensing e residual electrical voltages at the power terminals of the motor, thus eliminating the need for conventional tachometer equipment, additional mechanical components or modifications to the induction motor itself. The power terminal voltage signal is detected and transformed into a DC voltage proportional to the frequency of the signal. This DC voltage can be input to the control system of a variable frequency motor controller to regulate the output characteristics thereof relative to the speed of the coasting motor.

  2. Method and apparatus for monitoring the rotating frequency of de-energized induction motors

    DOE Patents [OSTI]

    Mikesell, H.E.; Lucy, E.

    1998-02-03T23:59:59.000Z

    The rotational speed of a coasting induction motor is measured by sensing e residual electrical voltages at the power terminals of the motor, thus eliminating the need for conventional tachometer equipment, additional mechanical components or modifications to the induction motor itself. The power terminal voltage signal is detected and transformed into a DC voltage proportional to the frequency of the signal. This DC voltage can be input to the control system of a variable frequency motor controller to regulate the output characteristics thereof relative to the speed of the coasting motor. 6 figs.

  3. Stepped frequency ground penetrating radar

    DOE Patents [OSTI]

    Vadnais, Kenneth G. (Ojai, CA); Bashforth, Michael B. (Buellton, CA); Lewallen, Tricia S. (Ventura, CA); Nammath, Sharyn R. (Santa Barbara, CA)

    1994-01-01T23:59:59.000Z

    A stepped frequency ground penetrating radar system is described comprising an RF signal generating section capable of producing stepped frequency signals in spaced and equal increments of time and frequency over a preselected bandwidth which serves as a common RF signal source for both a transmit portion and a receive portion of the system. In the transmit portion of the system the signal is processed into in-phase and quadrature signals which are then amplified and then transmitted toward a target. The reflected signals from the target are then received by a receive antenna and mixed with a reference signal from the common RF signal source in a mixer whose output is then fed through a low pass filter. The DC output, after amplification and demodulation, is digitized and converted into a frequency domain signal by a Fast Fourier Transform. A plot of the frequency domain signals from all of the stepped frequencies broadcast toward and received from the target yields information concerning the range (distance) and cross section (size) of the target.

  4. Constitutively Active Rap2 Transgenic Mice Display Fewer Dendritic Spines, Reduced Extracellular Signal-Regulated Kinase Signaling, Enhanced Long-Term Depression, and Impaired Spatial Learning and Fear Extinction

    E-Print Network [OSTI]

    Ryu, Jubin

    Within the Ras superfamily of GTPases, Rap1 and Rap2 are the closest homologs to Ras. In non-neural cells, Rap signaling can antagonize Ras signaling. In neurons, Rap also seems to oppose Ras in terms of synaptic function. ...

  5. Frequency-modulated atomic force microscopy operation by imaging at the frequency shift minimum: The dip-df mode

    SciTech Connect (OSTI)

    Rode, Sebastian; Schreiber, Martin; Kühnle, Angelika; Rahe, Philipp, E-mail: rahe@uni-mainz.de [Institut für Physikalische Chemie, Fachbereich Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10-14, 55099 Mainz (Germany)] [Institut für Physikalische Chemie, Fachbereich Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10-14, 55099 Mainz (Germany)

    2014-04-15T23:59:59.000Z

    In frequency modulated non-contact atomic force microscopy, the change of the cantilever frequency (?f) is used as the input signal for the topography feedback loop. Around the ?f(z) minimum, however, stable feedback operation is challenging using a standard proportional-integral-derivative (PID) feedback design due to the change of sign in the slope. When operated under liquid conditions, it is furthermore difficult to address the attractive interaction regime due to its often moderate peakedness. Additionally, the ?f signal level changes severely with time in this environment due to drift of the cantilever frequency f{sub 0} and, thus, requires constant adjustment. Here, we present an approach overcoming these obstacles by using the derivative of ?f with respect to z as the input signal for the topography feedback loop. Rather than regulating the absolute value to a preset setpoint, the slope of the ?f with respect to z is regulated to zero. This new measurement mode not only makes the minimum of the ?f(z) curve directly accessible, but it also benefits from greatly increased operation stability due to its immunity against f{sub 0} drift. We present isosurfaces of the ?f minimum acquired on the calcite CaCO{sub 3}(101{sup ¯}4) surface in liquid environment, demonstrating the capability of our method to image in the attractive tip-sample interaction regime.

  6. Analyzing Signals Fourier transform

    E-Print Network [OSTI]

    Sweldens, Wim

    Page 1 1 Analyzing Signals Fourier transform s frequency content s linear combination of sin frequency analysis s windowed Fourier transform 6 #12;Page 4 7 Gabor Transform function to analyze window Gabor Transform Spatial domain Gabor domain b #12;Page 5 9 Gabor Transform Problems s discrete version

  7. Library Regulations Library Regulations

    E-Print Network [OSTI]

    Birmingham, University of

    Library Regulations 2012-13 Library Regulations UNIVERSITY OF BIRMINGHAM REGULATIONS LIBRARY REGULATIONS Preamble: The Library Regulations apply to all users of library facilities managed on behalf of the University by Library Services, and thus there are sections that apply also to non- members of the University

  8. Wide band stepped frequency ground penetrating radar

    DOE Patents [OSTI]

    Bashforth, M.B.; Gardner, D.; Patrick, D.; Lewallen, T.A.; Nammath, S.R.; Painter, K.D.; Vadnais, K.G.

    1996-03-12T23:59:59.000Z

    A wide band ground penetrating radar system is described embodying a method wherein a series of radio frequency signals is produced by a single radio frequency source and provided to a transmit antenna for transmission to a target and reflection therefrom to a receive antenna. A phase modulator modulates those portions of the radio frequency signals to be transmitted and the reflected modulated signal is combined in a mixer with the original radio frequency signal to produce a resultant signal which is demodulated to produce a series of direct current voltage signals, the envelope of which forms a cosine wave shaped plot which is processed by a Fast Fourier Transform Unit 44 into frequency domain data wherein the position of a preponderant frequency is indicative of distance to the target and magnitude is indicative of the signature of the target. 6 figs.

  9. Wide band stepped frequency ground penetrating radar

    DOE Patents [OSTI]

    Bashforth, Michael B. (Buellton, CA); Gardner, Duane (Santa Maria, CA); Patrick, Douglas (Santa Maria, CA); Lewallen, Tricia A. (Ventura, CA); Nammath, Sharyn R. (Santa Barbara, CA); Painter, Kelly D. (Goleta, CA); Vadnais, Kenneth G. (Alexandria, VA)

    1996-01-01T23:59:59.000Z

    A wide band ground penetrating radar system (10) embodying a method wherein a series of radio frequency signals (60) is produced by a single radio frequency source (16) and provided to a transmit antenna (26) for transmission to a target (54) and reflection therefrom to a receive antenna (28). A phase modulator (18) modulates those portion of the radio frequency signals (62) to be transmitted and the reflected modulated signal (62) is combined in a mixer (34) with the original radio frequency signal (60) to produce a resultant signal (53) which is demodulated to produce a series of direct current voltage signals (66) the envelope of which forms a cosine wave shaped plot (68) which is processed by a Fast Fourier Transform unit 44 into frequency domain data (70) wherein the position of a preponderant frequency is indicative of distance to the target (54) and magnitude is indicative of the signature of the target (54).

  10. A quantitative comparison of sRNA-based and protein-based gene regulation

    E-Print Network [OSTI]

    Pankaj Mehta; Sidhartha Goyal; Ned S. Wingreen

    2008-09-02T23:59:59.000Z

    Small, non-coding RNAs (sRNAs) play important roles as genetic regulators in prokaryotes. sRNAs act post-transcriptionally via complementary pairing with target mRNAs to regulate protein expression. We use a quantitative approach to compare and contrast sRNAs with conventional transcription factors (TFs) to better understand the advantages of each form of regulation. In particular, we calculate the steady-state behavior, noise properties, frequency-dependent gain (amplification), and dynamical response to large input signals of both forms of regulation. While the mean steady-state behavior of sRNA-regulated proteins exhibits a distinctive tunable threshold-linear behavior, our analysis shows that transcriptional bursting leads to significantly higher intrinsic noise in sRNA-based regulation than in TF-based regulation in a large range of expression levels and limits the ability of sRNAs to perform quantitative signaling. Nonetheless, we find that sRNAs are better than TFs at filtering noise in input signals. Additionally, we find that sRNAs allow cells to respond rapidly to large changes in input signals. These features suggest a niche for sRNAs in allowing cells to transition quickly yet reliably between distinct states. This functional niche is consistent with the widespread appearance of sRNAs in stress-response and quasi-developmental networks in prokaryotes.

  11. advanced signal analysis: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    velocity, and it changes the impulse by absorbing some frequencies and delaying the signal in a process called FILTERING Ito, Garrett 75 Algebraic Signal Processing: Modeling...

  12. Variable frequency microprocessor clock generator

    SciTech Connect (OSTI)

    Branson, C.N.

    1989-04-04T23:59:59.000Z

    A microprocessor-based system is described comprising: a digital central microprocessor provided with a clock input and having a rate of operation determined by the frequency of a clock signal input thereto; memory means operably coupled to the central microprocessor for storing programs respectively including a plurality of instructions and addressable by the central microprocessor; peripheral device operably connected to the central microprocessor, the first peripheral device being addressable by the central microprocessor for control thereby; a system clock generator for generating a digital reference clock signal having a reference frequency rate; and frequency rate reduction circuit means connected between the clock generator and the clock input of the central microprocessor for selectively dividing the reference clock signal to generate a microprocessor clock signal as an input to the central microprocessor for clocking the central microprocessor.

  13. cAMP Signaling in the Gonadotropes

    E-Print Network [OSTI]

    Yeh, Debra Ming-Yi

    2012-01-01T23:59:59.000Z

    36 PACAP activates ERK and ELKgrowth response protein 1 ERK extracellular signal-regulated37 Figure 16: PACAP can activate ERK and

  14. Multi-mode radio frequency device

    DOE Patents [OSTI]

    Gilbert, Ronald W. (Morgan Hill, CA); Carrender, Curtis Lee (Morgan Hill, CA); Anderson, Gordon A. (Benton City, WA); Steele, Kerry D. (Kennewick, WA)

    2007-02-13T23:59:59.000Z

    A transponder device having multiple modes of operation, such as an active mode and a passive mode, wherein the modes of operation are selected in response to the strength of a received radio frequency signal. A communication system is also provided having a transceiver configured to transmit a radio frequency signal and to receive a responsive signal, and a transponder configured to operate in a plurality of modes and to activate modes of operation in response to the radio frequency signal. Ideally, each mode of operation is activated and deactivated independent of the other modes, although two or more modes may be concurrently operational.

  15. Variable frequency microwave furnace system

    DOE Patents [OSTI]

    Bible, Don W. (Clinton, TN); Lauf, Robert J. (Oak Ridge, TN)

    1994-01-01T23:59:59.000Z

    A variable frequency microwave furnace system (10) designed to allow modulation of the frequency of the microwaves introduced into a furnace cavity (34) for testing or other selected applications. The variable frequency microwave furnace system (10) includes a microwave signal generator (12) or microwave voltage-controlled oscillator (14) for generating a low-power microwave signal for input to the microwave furnace. A first amplifier (18) may be provided to amplify the magnitude of the signal output from the microwave signal generator (12) or the microwave voltage-controlled oscillator (14). A second amplifier (20) is provided for processing the signal output by the first amplifier (18). The second amplifier (20) outputs the microwave signal input to the furnace cavity (34). In the preferred embodiment, the second amplifier (20) is a traveling-wave tube (TWT). A power supply (22) is provided for operation of the second amplifier (20). A directional coupler (24) is provided for detecting the direction of a signal and further directing the signal depending on the detected direction. A first power meter (30) is provided for measuring the power delivered to the microwave furnace (32). A second power meter (26) detects the magnitude of reflected power. Reflected power is dissipated in the reflected power load (28).

  16. Variable frequency microwave furnace system

    DOE Patents [OSTI]

    Bible, D.W.; Lauf, R.J.

    1994-06-14T23:59:59.000Z

    A variable frequency microwave furnace system designed to allow modulation of the frequency of the microwaves introduced into a furnace cavity for testing or other selected applications. The variable frequency microwave furnace system includes a microwave signal generator or microwave voltage-controlled oscillator for generating a low-power microwave signal for input to the microwave furnace. A first amplifier may be provided to amplify the magnitude of the signal output from the microwave signal generator or the microwave voltage-controlled oscillator. A second amplifier is provided for processing the signal output by the first amplifier. The second amplifier outputs the microwave signal input to the furnace cavity. In the preferred embodiment, the second amplifier is a traveling-wave tube (TWT). A power supply is provided for operation of the second amplifier. A directional coupler is provided for detecting the direction of a signal and further directing the signal depending on the detected direction. A first power meter is provided for measuring the power delivered to the microwave furnace. A second power meter detects the magnitude of reflected power. Reflected power is dissipated in the reflected power load. 5 figs.

  17. Regulation XVI: GENERAL UNIVERSITY REGULATIONS

    E-Print Network [OSTI]

    Regulation XVI: GENERAL UNIVERSITY REGULATIONS APPLICATION AND INTERPRETATION 1. Unless stated otherwise, these and the following Regulations apply to students in all Faculties, including the International Faculty: General Regulations for First Degrees; General Regulations for Higher Degrees

  18. Lecture 2: Fourier transforms and frequency response

    E-Print Network [OSTI]

    Fan, Xingzhe

    Lecture 2: Fourier transforms and frequency response Course at a glance Discrete-time signals and systems Fourier-domain representation DFT/FFT System structures Filter structures Filter design Filter z-transform Sampling and reconstruction System analysis System Fourier transforms and frequency response Frequency

  19. A nonlinear optoelectronic filter for electronic signal processing

    E-Print Network [OSTI]

    Loh, William

    The conversion of electrical signals into modulated optical waves and back into electrical signals provides the capacity for low-loss radio-frequency (RF) signal transfer over optical fiber. Here, we show that the unique ...

  20. Rhode Island Pretreatment Regulations (Rhode Island)

    Broader source: Energy.gov [DOE]

    These regulations set standards for water pretreatment prior to release to Publicly Owned Treatment Works (POTWs), and require effluent data including the identity, amount, frequency, concentration...

  1. Self-Regulation as Two-Stage Rent-Seeking

    E-Print Network [OSTI]

    von Wangemheim, Georg

    2009-01-01T23:59:59.000Z

    interests and self-regulation; an economic approach (pp.Jose; Llobet, Gerard (2007): “Regulation, Corporate SocialA Signaling Motive for Self-Regulation in the Shadow of

  2. Radio-Frequency Rectification on Membrane Bound Pores

    E-Print Network [OSTI]

    Sujatha Ramachandran; Robert H. Blick; Daniel W. van der Weide

    2007-09-12T23:59:59.000Z

    We present measurements on direct radio-frequency pumping of ion channels and pores bound in bilipid membranes. We make use of newly developed microcoaxes, which allow delivering the high frequency signal in close proximity to the membrane bound proteins and ion channels. We find rectification of the radio-frequency signal, which is used to pump ions through the channels and pores.

  3. Multidimensional signal modulation and/or demodulation for data communications

    DOE Patents [OSTI]

    Smith, Stephen F. (London, TN); Dress, William B. (Camas, WA)

    2008-03-04T23:59:59.000Z

    Systems and methods are described for multidimensional signal modulation and/or demodulation for data communications. A method includes modulating a carrier signal in a first domain selected from the group consisting of phase, frequency, amplitude, polarization and spread; modulating the carrier signal in a second domain selected from the group consisting of phase, frequency, amplitude, polarization and spread; and modulating the carrier signal in a third domain selected from the group consisting of phase, frequency, amplitude, polarization and spread.

  4. Smart Frequency-Sensing Charge Controller for Electric Vehicles...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    for licensing:System uses frequency-sensing charge controllers that provide automatic demand response and regulation service to the grid by reducing or turning the charging...

  5. Assessing Emotion Regulation in Social Anxiety Disorder: The Emotion Regulation Interview

    E-Print Network [OSTI]

    Gross, James J.

    Assessing Emotion Regulation in Social Anxiety Disorder: The Emotion Regulation Interview Kelly H dysregulation in SAD has not been well characterized. In the present study, the Emotion Regulation Interview (ERI) was developed to quantify the frequency and self-efficacy of five emotion regulation strategies

  6. Frequency and phaselock control of a 3 THz quantum cascade laser.

    SciTech Connect (OSTI)

    Williams, Benjamin S. (Massachusetts Institute of Technology, Cambridge, MA); Hu, Qing (Massachusetts Institute of Technology, Cambridge, MA); Reno, John Louis; Boreiko, R. T. (University of Colorado, Boulder, CO); Betz, A. L. (University of Colorado, Boulder, CO); Kumar, S. (Massachusetts Institute of Technology, Cambridge, MA)

    2005-03-01T23:59:59.000Z

    We have locked the frequency of a 3 THz quantum cascade laser (QCL) to that of a far-infrared gas laser with a tunable microwave offset frequency. The locked QCL line shape is essentially Gaussian, with linewidths of 65 and 141 kHz at the -3 and -10 dB levels, respectively. The lock condition can be maintained indefinitely, without requiring temperature or bias current regulation of the QCL other than that provided by the lock error signal. The result demonstrates that a terahertz QCL can be frequency controlled with 1-part-in-108 accuracy, which is a factor of 100 better than that needed for a local oscillator in a heterodyne receiver for atmospheric and astronomic spectroscopy.

  7. Vibrational sum frequency study on biological interfaces

    E-Print Network [OSTI]

    Lim, Soon Mi

    2009-06-02T23:59:59.000Z

    , which is related to molecular orientation. Since the polarizabilities of molecules in bulk phase will be canceled out, a sum frequency signal can only be generated from interfaces where the inversion symmetry is broken. Because of its interfacial...

  8. Audio classification from time-frequency texture

    E-Print Network [OSTI]

    Slotine, Jean-Jacques E.

    Time-frequency representations of audio signals often resemble texture images. This paper derives a simple audio classification algorithm based on treating sound spectrograms as texture images. The algorithm is inspired ...

  9. Rajit Gadh and B.S. Prabhu, Radio Frequency Identification (RFID) for the assistance of Katrina related disaster mortuary operations, IEEE Signal Processing, expected to appear March 2006, based on invitation to write short article.

    E-Print Network [OSTI]

    California at Los Angeles, University of

    Rajit Gadh and B.S. Prabhu, Radio Frequency Identification (RFID) for the assistance of Katrina of Katrina Hurricane Victims Rajit Gadh and B.S. Prabhu Recently news.com reported that the U.S. Disaster

  10. Regulation of Notch by Itch AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Regulation of Notch by Itch 1 AIP4/Itch Regulates Notch Receptor Degradation in the AbsenceS ONE 3, 7 (2008) e2735" #12;Regulation of Notch by Itch 2 ABSTRACT Background. The regulation of Notch of ubiquitin-ligases, has been described as a negative regulator of Notch signaling, acting on the post

  11. Signaling pathways that regulate cellular senescence

    E-Print Network [OSTI]

    Freund, Adam Mark

    2010-01-01T23:59:59.000Z

    the retinoblastoma protein (pRb), which in turns inhibitsarrest by activating pRb and preventing E2F activity (be reversed by p53, p21, pRb, and/or p16 INK4A depletion at

  12. Regulation of PHLPP and Akt signaling

    E-Print Network [OSTI]

    Warfel, Noel Andrew

    2011-01-01T23:59:59.000Z

    S. Cheng, P. R. Shepherd, I. Gout, C. P. Downes, R. F. Lamb,S. Cheng, P. R. Shepherd, I. Gout, C. P. Downes, R. F. Lamb,

  13. Regulation of T-cell signaling networks

    E-Print Network [OSTI]

    Prabhakar, Arvind Shankar

    2013-01-01T23:59:59.000Z

    For a better understanding of how biology carries information within cells, it is not sufficient to look at individual protein or gene interactions, but to understand these networks of interactions as a whole. The goal of ...

  14. Mitogen-activated protein kinase kinase 1/extracellular signal-regulated kinase (MEK-1/ERK) inhibitors sensitize reduced glucocorticoid response mediated by TNF{alpha} in human epidermal keratinocytes (HaCaT)

    SciTech Connect (OSTI)

    Onda, Kenji [Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan)]. E-mail: knjond@ps.toyaku.ac.jp; Nagashima, Masahiro [Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan); Kawakubo, Yo [Department of Dermatology, Teikyo University School of Medicine, Ichihara Hospital, Chiba (Japan); Inoue, Shota [Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan); Hirano, Toshihiko [Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan); Oka, Kitaro [Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392 (Japan)

    2006-12-08T23:59:59.000Z

    Glucocorticoids (GCs) are essential drugs administered topically or systematically for the treatment of autoimmune skin diseases such as pemphigus. However, a certain proportion of patients does not respond well to GCs. Although studies on the relationship between cytokines and GC insensitivity in local tissues have attracted attention recently, little is known about the underlying mechanism(s) for GC insensitivity in epidermal keratinocytes. Here, we report that tumor necrosis factor (TNF) {alpha} reduces GC-induced transactivation of endogenous genes as well as a reporter plasmid which contains GC responsive element (GRE) in human epidermal keratinocyte cells (HaCaT). The GC insensitivity by TNF{alpha} was not accompanied by changes in mRNA expressions of GR isoforms ({alpha} or {beta}). However, we observed that mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase (MEK-1/ERK) inhibitors (PD98059 and U0126) significantly sensitized the GC-induced transactivation of anti-inflammatory genes (glucocorticoid-induced leucine zipper (GILZ) and mitogen-activated protein kinase phosphatase (MKP)-1) and FK506 binding protein (FKBP) 51 gene in the presence of TNF{alpha}. Additionally, we observed that TNF{alpha} reduced prednisolone (PSL)-dependent nuclear translocation of GR, which was restored by pre-treatment of MEK-1 inhibitors. This is the first study demonstrating a role of the MEK-1/ERK cascade in TNF{alpha}-mediated GC insensitivity. Our data suggest that overexpression of TNF{alpha} leads to topical GC insensitivity by reducing GR nuclear translocation in keratinocytes, and our findings also suggest that inhibiting the MEK-1/ERK cascade may offer a therapeutic potential for increasing GC efficacy in epidermis where sufficient inflammatory suppression is required.

  15. mTOR Signaling in Growth Control and Disease

    E-Print Network [OSTI]

    Laplante, Mathieu

    The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is ...

  16. Regulation of cell fate by phosphorylation : a tale of two transcription factors

    E-Print Network [OSTI]

    Tootle, Tina Louise

    2004-01-01T23:59:59.000Z

    As transcription factors are the nuclear effectors of signaling cascades, mechanisms must exist to specifically regulate their activities in response to signaling events. Regulation can occur at the DNA, RNA, or protein ...

  17. Monitoring method and apparatus using high-frequency carrier

    DOE Patents [OSTI]

    Haynes, Howard D. (Knoxville, TN)

    1996-01-01T23:59:59.000Z

    A method and apparatus for monitoring an electrical-motor-driven device by injecting a high frequency carrier signal onto the power line current. The method is accomplished by injecting a high frequency carrier signal onto an AC power line current. The AC power line current supplies the electrical-motor-driven device with electrical energy. As a result, electrical and mechanical characteristics of the electrical-motor-driven device modulate the high frequency carrier signal and the AC power line current. The high frequency carrier signal is then monitored, conditioned and demodulated. Finally, the modulated high frequency carrier signal is analyzed to ascertain the operating condition of the electrical-motor-driven device.

  18. Monitoring method and apparatus using high-frequency carrier

    DOE Patents [OSTI]

    Haynes, H.D.

    1996-04-30T23:59:59.000Z

    A method and apparatus for monitoring an electrical-motor-driven device by injecting a high frequency carrier signal onto the power line current. The method is accomplished by injecting a high frequency carrier signal onto an AC power line current. The AC power line current supplies the electrical-motor-driven device with electrical energy. As a result, electrical and mechanical characteristics of the electrical-motor-driven device modulate the high frequency carrier signal and the AC power line current. The high frequency carrier signal is then monitored, conditioned and demodulated. Finally, the modulated high frequency carrier signal is analyzed to ascertain the operating condition of the electrical-motor-driven device. 6 figs.

  19. Carrier-frequency synchronization system for improved amplitude modulation and television broadcast reception

    DOE Patents [OSTI]

    Smith, Stephen F.; Moore, James A.

    2003-05-13T23:59:59.000Z

    Systems and methods are described for carrier-frequency synchronization for improved AM and TV broadcast reception. A method includes synchronizing a carrier frequency of a broadcast signal with a remote reference frequency. An apparatus includes a reference signal receiver; a phase comparator coupled to the reference signal receiver; a voltage controlled oscillator coupled to the phase comparator; and a radio frequency output coupled to the voltage controlled oscillator.

  20. Synchronizing carrier frequencies of co-channel amplitude-modulated broadcast

    DOE Patents [OSTI]

    Smith, Stephen F. (London, TN); Moore, James A. (Powell, TN)

    2007-05-15T23:59:59.000Z

    Systems and methods are described for carrier-frequency synchronization for improved AM and TV broadcast reception. A method includes synchronizing a carrier frequency of a broadcast signal with a remote reference frequency. An apparatus includes a reference signal receiver; a phase comparator coupled to the reference signal receiver; a voltage controlled oscillator coupled to the phase comparator; and a radio frequency output coupled to the voltage controlled oscillator.

  1. Probing Signal Design for Power System Identification

    SciTech Connect (OSTI)

    Pierre, John W.; Zhou, Ning; Tuffner, Francis K.; Hauer, John F.; Trudnowski, Daniel J.; Mittelstadt, William

    2010-05-31T23:59:59.000Z

    This paper investigates the design of effective input signals for low-level probing of power systems. In 2005, 2006, and 2008 the Western Electricity Coordinating Council (WECC) conducted four large-scale system wide tests of the western interconnected power system where probing signals were injected by modulating the control signal at the Celilo end of the Pacific DC intertie. A major objective of these tests is the accurate estimation of the inter-area electromechanical modes. A key aspect of any such test is the design of an effective probing signal that leads to measured outputs rich in information about the modes. This paper specifically studies low-level probing signal design for power-system identification. The paper describes the design methodology and the advantages of this new probing signal which was successfully applied during these tests. This probing input is a multi-sine signal with its frequency content focused in the range of the inter-area modes. The period of the signal is over two minutes providing high-frequency resolution. Up to 15 cycles of the signal are injected resulting in a processing gain of 15. The resulting system response is studied in the time and frequency domains. Because of the new probing signal characteristics, these results show significant improvement in the output SNR compared to previous tests.

  2. Laminin isoforms differentially regulate adhesion, spreading, proliferation, and ERK activation of h1 integrin-null cells

    E-Print Network [OSTI]

    Campbell, Kevin P.

    Laminin isoforms differentially regulate adhesion, spreading, proliferation, and ERK activation signal-regulated kinase (ERK) activation, whereas all these responses occurred in response to adhesion

  3. Compensation of the AKT signaling by ERK signaling in transgenic mice hearts overexpressing TRIM72

    SciTech Connect (OSTI)

    Ham, Young-Mi, E-mail: youngmi_ham@hms.harvard.edu [College of Life Science and Biotechnology, Korea University, Seoul (Korea, Republic of); Department of Cell Biology, Harvard Medical School, Boston, MA 02115 (United States); Mahoney, Sarah Jane [Department of Cell Biology, Harvard Medical School, Boston, MA 02115 (United States)

    2013-06-10T23:59:59.000Z

    The AKT and ERK signaling pathways are known to be involved in cell hypertrophy, proliferation, survival and differentiation. Although there is evidence for crosstalk between these two signaling pathways in cellulo, there is less evidence for cross talk in vivo. Here, we show that crosstalk between AKT and ERK signaling in the hearts of TRIM72-overexpressing transgenic mice (TRIM72-Tg) with alpha-MHC promoter regulates and maintains their heart size. TRIM72, a heart- and skeletal muscle-specific protein, downregulates AKT-mTOR signaling via IRS-1 degradation and reduces the size of rat cardiomyocytes and the size of postnatal TRIM72-Tg hearts. TRIM72 expression was upregulated by hypertrophic inducers in cardiomyocytes, while IRS-1 was downregulated by IGF-1. TRIM72 specifically regulated IGF-1-dependent AKT-mTOR signaling, resulting in a reduction of the size of cardiomyocytes. Postnatal TRIM72-Tg hearts were smaller than control-treated hearts with inhibition of AKT-mTOR signaling. However, adult TRIM72-Tg hearts were larger than of control despite the suppression of AKT-mTOR signaling. Activation of ERK, PKC-?, and JNK were observed to be elevated in adult TRIM72-Tg, and these signals were mediated by ET-1 via the ET receptors A and B. Altogether, these results suggest that AKT signaling regulates cardiac hypertrophy in physiological conditions, and ERK signaling compensates for the absence of AKT signaling during TRIM72 overexpression, leading to pathological hypertrophy. -- Highlights: • TRIM72 inhibits AKT signaling through ubiquitination of IRS-1 in cardiac cells. • TRIM72 regulates the size of cardiac cells. • TRIM72 regulates size of postnatal TRIM72-overexpressing transgenic mice hearts. • Adult TRIM72-overexpressing transgenic mice hearts showed cardiac dysfunction. • Adult TRIM72 transgenic mice hearts showed higher expression of endothelin receptors.

  4. Investigating the suppressive effects of a low-frequency bias-tone on auditory-nerve responses to tail-frequency tones

    E-Print Network [OSTI]

    Nam, Hui S., Ph. D. (Hui Sok) Massachusetts Institute of Technology

    2011-01-01T23:59:59.000Z

    Sounds are amplified and frequency analyzed in the cochlea and the resulting signals are sent to the brain through the auditory nerve (AN). AN fiber threshold vs. frequency-response characteristics are band-pass shaped, ...

  5. Time-Frequency Analysis as Probabilistic Inference

    E-Print Network [OSTI]

    Turner, Richard E.

    2014-11-06T23:59:59.000Z

    (see supplementary material). The computational complexity is determined by the cost of the Kalman smoother to be . In practice, optimization of the likelihood by the conjugate gradient algorithm converged far more quickly than alternatives like... -varying) signal-de- pendent adaptation of the representation. Similarly, corruption of a signal by noise or missing samples should introduce uncer- tainty into the values of the time-frequency representation; but again, no unified robust method exists...

  6. Regulation XVII: GENERAL REGULATIONS FOR FIRST DEGREES

    E-Print Network [OSTI]

    Regulation XVII: GENERAL REGULATIONS FOR FIRST DEGREES SCOPE OF THESE REGULATIONS4 1. These Regulations apply, subject to any different provision in the Regulations for a particular programme of study programme of study is designated as a non-modular programme, Regulation 14 and subsequent Regulations

  7. Alternative Regulation (Vermont)

    Broader source: Energy.gov [DOE]

    Utility regulators, including the Public Service Board, have applied a new type of regulation, often called "alternative regulation" or "incentive regulation." There are many variants of this type...

  8. Multichannel heterodyning for wideband interferometry, correlation and signal processing

    DOE Patents [OSTI]

    Erskine, D.J.

    1999-08-24T23:59:59.000Z

    A method is disclosed of signal processing a high bandwidth signal by coherently subdividing it into many narrow bandwidth channels which are individually processed at lower frequencies in a parallel manner. Autocorrelation and correlations can be performed using reference frequencies which may drift slowly with time, reducing cost of device. Coordinated adjustment of channel phases alters temporal and spectral behavior of net signal process more precisely than a channel used individually. This is a method of implementing precision long coherent delays, interferometers, and filters for high bandwidth optical or microwave signals using low bandwidth electronics. High bandwidth signals can be recorded, mathematically manipulated, and synthesized. 50 figs.

  9. Multichannel heterodyning for wideband interferometry, correlation and signal processing

    DOE Patents [OSTI]

    Erskine, David J. (Oakland, CA)

    1999-01-01T23:59:59.000Z

    A method of signal processing a high bandwidth signal by coherently subdividing it into many narrow bandwidth channels which are individually processed at lower frequencies in a parallel manner. Autocorrelation and correlations can be performed using reference frequencies which may drift slowly with time, reducing cost of device. Coordinated adjustment of channel phases alters temporal and spectral behavior of net signal process more precisely than a channel used individually. This is a method of implementing precision long coherent delays, interferometers, and filters for high bandwidth optical or microwave signals using low bandwidth electronics. High bandwidth signals can be recorded, mathematically manipulated, and synthesized.

  10. Method of detecting system function by measuring frequency response

    DOE Patents [OSTI]

    Morrison, John L.; Morrison, William H.; Christophersen, Jon P.; Motloch, Chester G.

    2013-01-08T23:59:59.000Z

    Methods of rapidly measuring an impedance spectrum of an energy storage device in-situ over a limited number of logarithmically distributed frequencies are described. An energy storage device is excited with a known input signal, and a response is measured to ascertain the impedance spectrum. An excitation signal is a limited time duration sum-of-sines consisting of a select number of frequencies. In one embodiment, magnitude and phase of each frequency of interest within the sum-of-sines is identified when the selected frequencies and sample rate are logarithmic integer steps greater than two. This technique requires a measurement with a duration of one period of the lowest frequency. In another embodiment, where selected frequencies are distributed in octave steps, the impedance spectrum can be determined using a captured time record that is reduced to a half-period of the lowest frequency.

  11. Frequency Measurement & Analysis Service

    E-Print Network [OSTI]

    Magee, Joseph W.

    NIST Frequency Measurement & Analysis Service #12;A Complete Solution To All Frequency Measurement & Calibration Problems The NIST Frequency Measurement and Analysis Service makes it easy to measure and calibrate any quartz, rubidium, or cesium frequency standard. All measurements are made automatically

  12. Government Regulation

    E-Print Network [OSTI]

    Ashford, Nicholas

    2005-01-01T23:59:59.000Z

    Abstract. Interest in the use of so-called voluntary approaches to supplement or replace formal environmental regulation is on the rise, both in Europe and in the United States. These approaches fall into two general ...

  13. Signal separation of musical instruments: simulation-based methods for musical signal decomposition and transcription

    E-Print Network [OSTI]

    Walmsley, Paul Jospeh

    2001-05-29T23:59:59.000Z

    , hiss, clicks and 1 Including, perversely, simulating the characteristics of magnetic tape and other analogue equipment. 18 1. Introduction wow [54, 154, 163] and nonlinear distortions [151], operate upon the entire signal, as all signal components... -tuned or inharmonic instruments such as percussion and bells. A struck cymbal generates a signal which has energy distributed over a wide range of frequencies, and evokes no definite pitch sensation4 so common periodicity is not a viable cue. The spectral com...

  14. Broadband frequency mode entanglement in waveguided PDC

    E-Print Network [OSTI]

    Eckstein, Andreas

    2008-01-01T23:59:59.000Z

    We report the observation of beatings of the coincidence event rate in a Hong-Ou-Mandel interference (HOMI) between signal and idler photons from a parametric downconversion process inside a multi-mode KTP waveguide. As explanation we introduce bi-photonic states entangled in their broadband frequency modes and propose a suitable entanglement witness.

  15. Broadband frequency mode entanglement in waveguided PDC

    E-Print Network [OSTI]

    Andreas Eckstein; Christine Silberhorn

    2008-07-04T23:59:59.000Z

    We report the observation of beatings of the coincidence event rate in a Hong-Ou-Mandel interference (HOMI) between signal and idler photons from a parametric downconversion (PDC) process inside a multi-mode KTP waveguide. As explanation we introduce bi-photonic states entangled in their broadband frequency modes generated by waveguide mode triples and propose a suitable entanglement detection scheme.

  16. Regulation 29: Other Regulations concerning the University site and buildings, Computing Regulations and Miscellaneous Administrative Regulations

    E-Print Network [OSTI]

    Sussex, University of

    Regulations and Miscellaneous Administrative Regulations 190 nuisance to occupants, except in designated (Vehicle Operators and Penalty Notices) Regulations; (iii) allow smoking in designated study bedroomsRegulation 29: Other Regulations concerning the University site and buildings, Computing

  17. High level indole signalling in Escherichia coli

    E-Print Network [OSTI]

    Gaimster, Hannah Dorne

    2014-06-10T23:59:59.000Z

    indole signalling in Escherichia coli Abstract Indole is a small signalling molecule, produced by many species of bacteria, including Escherichia coli. It is made by the enzyme tryptophanase, which converts tryptophan into indole, pyruvate and ammonia... . Indole has diverse roles in E. coli, including regulation of biofilm formation, acid resistance and pathogenicity. In these cases, E. coli responds to a low, persistent level of indole (0.5-1 mM), similar to the concentration found in an E. coli...

  18. Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk

    E-Print Network [OSTI]

    Elowitz, Michael

    Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk, operates downstream of FGF/Erk MAP kinase signaling to regulate pluripotency and cell fate decision making in mouse embryonic stem cells (mESCs). FGF/Erk MAP kinase signaling up-regulates Brf1, which disrupts

  19. System for surveillance of spectral signals

    DOE Patents [OSTI]

    Gross, Kenneth C. (Bolingbrook, IL); Wegerich, Stephan W. (Glendale Heights, IL); Criss-Puszkiewicz, Cynthia (Reno, NV); Wilks, Alan D. (Mt. Prospect, IL)

    2001-01-01T23:59:59.000Z

    A method and system for monitoring at least one of a system, a process and a data source. A method and system have been developed for carrying out surveillance, testing and modification of an ongoing process or other source of data, such as a spectroscopic examination. A signal from the system under surveillance is collected and compared with a reference signal, a frequency domain transformation carried out for the system signal and reference signal, a frequency domain difference function established. The process is then repeated until a full range of data is accumulated over the time domain and a SPRT sequential probability ratio test methodology applied to determine a three-dimensional surface plot characteristic of the operating state of the system under surveillance.

  20. System For Surveillance Of Spectral Signals

    DOE Patents [OSTI]

    Gross, Kenneth C. (Bolingbrook, IL); Wegerich, Stephan W. (Glendale Heights, IL); Criss-Puszkiewicz, Cynthia (Reno, NV); Wilks, Alan D. (Mount Prospect, IL)

    2004-10-12T23:59:59.000Z

    A method and system for monitoring at least one of a system, a process and a data source. A method and system have been developed for carrying out surveillance, testing and modification of an ongoing process or other source of data, such as a spectroscopic examination. A signal from the system under surveillance is collected and compared with a reference signal, a frequency domain transformation carried out for the system signal and reference signal, a frequency domain difference function established. The process is then repeated until a full range of data is accumulated over the time domain and a Sequential Probability Ratio Test ("SPRT") methodology applied to determine a three-dimensional surface plot characteristic of the operating state of the system under surveillance.

  1. System For Surveillance Of Spectral Signals

    DOE Patents [OSTI]

    Gross, Kenneth C. (Bolingbrook, IL); Wegerich, Stephan (Glendale Heights, IL); Criss-Puszkiewicz, Cynthia (Reno, NV); Wilks, Alan D. (Mount Prospect, IL)

    2003-04-22T23:59:59.000Z

    A method and system for monitoring at least one of a system, a process and a data source. A method and system have been developed for carrying out surveillance, testing and modification of an ongoing process or other source of data, such as a spectroscopic examination. A signal from the system under surveillance is collected and compared with a reference signal, a frequency domain transformation carried out for the system signal and reference signal, a frequency domain difference function established. The process is then repeated until a full range of data is accumulated over the time domain and a Sequential Probability Ratio Test methodology applied to determine a three-dimensional surface plot characteristic of the operating state of the system under surveillance.

  2. Eastern Frequency Response Study

    SciTech Connect (OSTI)

    Miller, N.W.; Shao, M.; Pajic, S.; D'Aquila, R.

    2013-05-01T23:59:59.000Z

    This study was specifically designed to investigate the frequency response of the Eastern Interconnection that results from large loss-of-generation events of the type targeted by the North American Electric Reliability Corp. Standard BAL-003 Frequency Response and Frequency Bias Setting (NERC 2012a), under possible future system conditions with high levels of wind generation.

  3. Modelling the influence of RKIP on the ERK signalling pathway using the stochastic process

    E-Print Network [OSTI]

    Gilmore, Stephen

    Modelling the influence of RKIP on the ERK signalling pathway using the stochastic process algebra) on the Extracellular signal Regulated Kinase (ERK) signalling pathway [1] through modelling in a Markovian process choices. The system which we consider is the Ras/Raf-1/MEK/ERK signalling path- way, as presented in [1

  4. Real-time monitoring of cyclic nucleotide signaling in neurons using genetically-

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    -time monitoring of cyclic nucleotide signaling in neurons using genetically- encoded FRET probes Pierre VINCENT1: The signaling cascades involving cyclic nucleotides play a key role in signal transduction in virtually all cell types. Elucidation of the spatiotemporal regulation of cyclic nucleotide signaling requires methods

  5. Frequency selective infrared sensors

    SciTech Connect (OSTI)

    Davids, Paul; Peters, David W

    2014-11-25T23:59:59.000Z

    A frequency selective infrared (IR) photodetector having a predetermined frequency band. The exemplary frequency selective photodetector includes: a dielectric IR absorber having a first surface and a second surface substantially parallel to the first surface; an electrode electrically coupled to the first surface of the dielectric IR absorber; and a frequency selective surface plasmonic (FSSP) structure formed on the second surface of the dielectric IR absorber. The FSSP structure is designed to selectively transmit radiation in the predetermined frequency band that is incident on the FSSP structure substantially independent of the angle of incidence of the incident radiation on the FSSP structure.

  6. Frequency selective infrared sensors

    DOE Patents [OSTI]

    Davids, Paul; Peters, David W

    2013-05-28T23:59:59.000Z

    A frequency selective infrared (IR) photodetector having a predetermined frequency band. The exemplary frequency selective photodetector includes: a dielectric IR absorber having a first surface and a second surface substantially parallel to the first surface; an electrode electrically coupled to the first surface of the dielectric IR absorber; and a frequency selective surface plasmonic (FSSP) structure formed on the second surface of the dielectric IR absorber. The FSSP structure is designed to selectively transmit radiation in the predetermined frequency band that is incident on the FSSP structure substantially independent of the angle of incidence of the incident radiation on the FSSP structure.

  7. Regulation XVIII: GENERAL REGULATIONS FOR HIGHER DEGREES,

    E-Print Network [OSTI]

    Regulation XVIII: GENERAL REGULATIONS FOR HIGHER DEGREES, POSTGRADUATE DIPLOMAS AND POSTGRADUATE CERTIFICATES SCOPE OF THESE REGULATIONS 1. These Regulations apply to the Degree of PhD in all Faculties in all Faculties Postgraduate Certificates in all Faculties. 2. These Regulations are subject

  8. Regulation 28: Library REGULATION 28: LIBRARY

    E-Print Network [OSTI]

    Sussex, University of

    Regulation 28: Library 180 REGULATION 28: LIBRARY The purpose of this Regulation is to safeguard the common interests of all Library users. All persons are admitted on the understanding that they have read and agreed to observe the Library Regulations. Breach of this Regulation could result in membership being

  9. Continuous time very low frequency analog signal processors

    E-Print Network [OSTI]

    Veeravalli Raghupathy, Anand

    2000-01-01T23:59:59.000Z

    with two floating gate transistors. . 31 Variation of GM with the tuning voltage x. 56 32 Transient simulations. . . . . . . 57 33 Variation of THD with input voltage y for x = 100mV. . . . . . 58 34 Variation of THD with x for 1Vpp input. 59 FIGURE... order systems is shown in Fig. 1(a). The basic OTA-C implementation of the simple integrator [17] is shown in Fig. 1(b). V, n + 0Ut OUt Vln GM int (a) (b) Fig. I. (a) Integrator block diagram. (b) OTA-C implementation. The output voltage V...

  10. Optimizing frequency dispersed transient absorption signals: A computational study

    E-Print Network [OSTI]

    Röder, Beate

    control of molecular dynamics is studied theoretically by focusing on optical excitation and wave packet stimulated emission or excited state absorption. By applying Optimal Control Theory the concept is demonstrated for a prototypical molecular three level system, whereby a flexible technique is suggested to form

  11. CHARACTERIZATION OF COMPLEX SIGNALS USING TIME-FREQUENCY-PHASE CONCEPT

    E-Print Network [OSTI]

    Boyer, Edmond

    @mta.ro +++ : Dept of Electrical Engineering, University of Montenegro, 81000 Podgorica, Montenegro E-mail : srdjan

  12. The design and synthesis of nuclear localization signal (NLS) mimics

    E-Print Network [OSTI]

    Ho, Thai Huu

    2013-02-22T23:59:59.000Z

    Nuclear import of proteins is a carefully controlled process that is critical for cellular function and regulation. A protein is marked for nuclear entry by a nuclear localization signal (NLS), a peptide motif, which typically consists of one or two...

  13. Signal Processing and Communication An Overview for Prospective Students

    E-Print Network [OSTI]

    Schniter, Philip

    , wind, solar, heat · Energy distribution · Energy storage ­ smart batteries Computer Systems & Networks · Antennas ­ mobile, satellite · Radar ­ weather, navigation, defense · Emission regulation ­ compatibility · Analog, digital, and microwave circuits · Mixed-signal ICs #12;Power Systems · Energy conversion ­ hydro

  14. Motor monitoring method and apparatus using high frequency current components

    DOE Patents [OSTI]

    Casada, Donald A. (Knoxville, TN)

    1996-01-01T23:59:59.000Z

    A motor current analysis method and apparatus for monitoring electrical-motor-driven devices. The method and apparatus utilize high frequency portions of the motor current spectra to evaluate the condition of the electric motor and the device driven by the electric motor. The motor current signal produced as a result of an electric motor is monitored and the low frequency components of the signal are removed by a high-pass filter. The signal is then analyzed to determine the condition of the electrical motor and the driven device.

  15. Assessing the Value of Regulation Resources Based on Their Time Response Characteristics

    SciTech Connect (OSTI)

    Makarov, Yuri V.; Lu, Shuai; Ma, Jian; Nguyen, Tony B.

    2008-06-01T23:59:59.000Z

    Fast responsive regulation resources are potentially more valuable as a power system regulation resource (more efficient) because they allow applying controls at the exact moment and in the exact amount as needed. Faster control is desirable because it facilitates more reliable compliance with the NERC Control Performance Standards at relatively lesser regulation capacity procurements. The current California ISO practices and markets do not provide a differentiation among the regulation resources based on their speed of response (with the exception of some minimum ramping capabilities). Some demand response technologies, including some generation and energy storage resources, can provide quicker control actions. California ISO practices and markets could be updated to welcome more fast regulation resources into the California ISO service area. The project work reported in this work was pursuing the following objectives: • Develop methodology to assess the relative value of generation resources used for regulation and load following California ISO functions • This assessment should be done based on physical characteristics including the ability to quickly change their output following California ISO signals • Evaluate what power is worth on different time scales • Analyze the benefits of new regulation resources to provide effective compliance with the mandatory NERC Control Performance Standards • Evaluate impacts of the newly proposed BAAL and FRR standards on the potential value of fast regulation and distributed regulation resources • Develop a scope for the follow-up projects to pave a road for the new efficient types of balancing resources in California. The work included the following studies: • Analysis of California ISO regulating units characteristics • California ISO automatic generation system (AGC) analysis • California ISO regulation procurement and market analysis • Fast regulation efficiency analysis • Projection of the California ISO load following and regulation requirements into the future • Value of fast responsive resources depending on their ramping capability • Potential impacts of the balancing authority area control error limit (BAAL), which is a part of the newly proposed NERC standard “Balancing Resources and Demand” • Potential impacts of the Western Electricity Coordinating Council (WECC) frequency responsive reserve (FRR) standard • Recommendations for the next phase of the project. The following main conclusions and suggestions for the future have been made: • The analysis of regulation ramping requirements shows that the regulation system should be able to provide ramps of at least 40-60 MW per minute for a period up to 6 minutes. • Evaluate if changes are needed in the California ISO AGC system to effectively accommodate new types of fast regulation resources and minimize the California ISO regulation procurement. • California ISO may consider creating better market opportunities for and incentives for fast responsive resources. • An additional study of low probability high ramp events can be recommended to the California ISO. • The California ISO may be willing to consider establishing a more relaxed target CPS2 compliance level. • A BAAL-related study can be recommended for the California ISO as soon as more clarity is achieved concerning the actual enforcement of the BAAL standard and its numerical values for the California ISO. The study may involve an assessment of advantages of the distributed frequency-based control for the California ISO system. The market-related issues that arise in this connection can be also investigated. • A FRR-related study can be recommended for the California ISO as soon as more clarity is achieved concerning the actual enforcement of the FRR standard and its numerical values for the California ISO.

  16. Regulation of Meiotic Recombination

    SciTech Connect (OSTI)

    Gregory p. Copenhaver

    2011-11-09T23:59:59.000Z

    Meiotic recombination results in the heritable rearrangement of DNA, primarily through reciprocal exchange between homologous chromosome or gene conversion. In plants these events are critical for ensuring proper chromosome segregation, facilitating DNA repair and providing a basis for genetic diversity. Understanding this fundamental biological mechanism will directly facilitate trait mapping, conventional plant breeding, and development of genetic engineering techniques that will help support the responsible production and conversion of renewable resources for fuels, chemicals, and the conservation of energy (1-3). Substantial progress has been made in understanding the basal recombination machinery, much of which is conserved in organisms as diverse as yeast, plants and mammals (4, 5). Significantly less is known about the factors that regulate how often and where that basal machinery acts on higher eukaryotic chromosomes. One important mechanism for regulating the frequency and distribution of meiotic recombination is crossover interference - or the ability of one recombination event to influence nearby events. The MUS81 gene is thought to play an important role in regulating the influence of interference on crossing over. The immediate goals of this project are to use reverse genetics to identify mutants in two putative MUS81 homologs in the model plant Arabidopsis thaliana, characterize those mutants and initiate a novel forward genetic screen for additional regulators of meiotic recombination. The long-term goal of the project is to understand how meiotic recombination is regulated in higher eukaryotes with an emphasis on the molecular basis of crossover interference. The ability to monitor recombination in all four meiotic products (tetrad analysis) has been a powerful tool in the arsenal of yeast geneticists. Previously, the qrt mutant of Arabidopsis, which causes the four pollen products of male meiosis to remain attached, was developed as a facile system for assaying recombination using tetrad analysis in a higher eukaryotic system (6). This system enabled the measurement of the frequency and distribution of recombination events at a genome wide level in wild type Arabidopsis (7), construction of genetic linkage maps which include positions for each centromere (8), and modeling of the strength and pattern of interference (9). This proposal extends the use of tetrad analysis in Arabidopsis by using it as the basis for assessing the phenotypes of mutants in genes important for recombination and the regulation of crossover interference and performing a novel genetic screen. In addition to broadening our knowledge of a classic genetic problem - the regulation of recombination by crossover interference - this proposal also provides broader impact by: generating pedagogical tools for use in hands-on classroom experience with genetics, building interdisciplinary collegial partnerships, and creating a platform for participation by junior scientists from underrepresented groups. There are three specific aims: (1) Isolate mutants in Arabidopsis MUS81 homologs using T-DNA and TILLING (2) Characterize recombination levels and interference in mus81 mutants (3) Execute a novel genetic screen, based on tetrad analysis, for genes that regulate meiotic recombination

  17. Resonance at the Rabi frequency in a superconducting flux qubit

    SciTech Connect (OSTI)

    Greenberg, Ya. S. [Novosibirsk State Technical University, Novosibirsk (Russian Federation); Il'ichev, E.; Oelsner, G. [common Leibniz Institute of Photonic Technology, Jena (Germany); Shevchenko, S. N. [B. Verkin Institute for Low Temperature Physics and Engineering, Kharkov, Ukraine and V. Karazin Kharkov National University, Kharkov (Ukraine)

    2014-10-15T23:59:59.000Z

    We analyze a system composed of a superconducting flux qubit coupled to a transmission-line resonator driven by two signals with frequencies close to the resonator's harmonics. The first strong signal is used for exciting the system to a high energetic state while a second weak signal is applied for probing effective eigenstates of the system. In the framework of doubly dressed states we showed the possibility of amplification and attenuation of the probe signal by direct transitions at the Rabi frequency. We present a brief review of theoretical and experimental works where a direct resonance at Rabi frequency have been investigated in superconducting flux qubits. The interaction of the qubit with photons of two harmonics has prospects to be used as a quantum amplifier (microwave laser) or an attenuator.

  18. Tone signal generator for producing multioperator tone signals using an operator circuit including a waveform generator, a selector and an enveloper

    DOE Patents [OSTI]

    Dong, Q.; Jenkins, M.V.; Bernadas, S.R.

    1997-09-09T23:59:59.000Z

    A frequency modulation (FM) tone signal generator for generating a FM tone signal is disclosed. The tone signal generator includes a waveform generator having a plurality of wave tables, a selector and an enveloper. The waveform generator furnishes a waveform signal in response to a phase angle address signal. Each wave table stores a different waveform. The selector selects one of the wave tables in response to a plurality of selection signals such that the selected wave table largely provides the waveform signal upon being addressed largely by the phase angle address signal. Selection of the selected wave table varies with each selection signal. The enveloper impresses an envelope signal on the waveform signal. The envelope signal is used as a carrier or modulator for generating the FM tone signal. 17 figs.

  19. Intracellular Signaling by the Unfolded Protein

    E-Print Network [OSTI]

    Mullins, Dyche

    reticulum stress, signal transduction, organelle homeostasis, protein folding, regulated mRNA splicing triggers an exten- sive transcriptional response, which adjusts the ER protein folding capacity according to reestablish homeostasis in the cell's protein folding capacity or--if this cannot be achieved-- commit cells

  20. Activin/Nodal signalling in stem cells

    E-Print Network [OSTI]

    Pauklin, Siim; Vallier, Ludovic

    2015-02-15T23:59:59.000Z

      independently   (Figure   4).   This   mechanism   could   involve   Sox2   since   this   gene   is   regulated  in  hPSCs  by  ERK2,  an  effector  of  the  FGF  signalling  (Yu  et  al.,  2011).  Thus...   et   al.,   2008).   Accordingly,   mESCs   self-­?renewal   can   be   stabilised   by   chemically   inhibiting   GSK3?   and   the   ERK   kinase   pathway   in   the   absence   of   exogenous   growth...

  1. A Monolithic Programmable Optical Filter for RF-Signal Processing

    E-Print Network [OSTI]

    Coldren, Larry A.

    abilities in the frequency domain, properties that are crucial for electronic warfare (EW) systems electronic counterparts [1,2]. By rapidly pre-filtering wide bandwidth analog signals in the optical domain

  2. Charge regulation circuit

    DOE Patents [OSTI]

    Ball, Don G. (Livermore, CA)

    1992-01-01T23:59:59.000Z

    A charge regulation circuit provides regulation of an unregulated voltage supply in the range of 0.01%. The charge regulation circuit is utilized in a preferred embodiment in providing regulated voltage for controlling the operation of a laser.

  3. Frequency Response Analysis Tool

    SciTech Connect (OSTI)

    Etingov, Pavel V.; Kosterev, Dmitry; Dai, T.

    2014-12-31T23:59:59.000Z

    Frequency response has received a lot of attention in recent years at the national level, which culminated in the development and approval of North American Electricity Reliability Corporation (NERC) BAL-003-1 Frequency Response and Frequency Bias Setting Reliability Standard. This report is prepared to describe the details of the work conducted by Pacific Northwest National Laboratory (PNNL) in collaboration with the Bonneville Power Administration and Western Electricity Coordinating Council (WECC) Joint Synchronized Information Subcommittee (JSIS) to develop a frequency response analysis tool (FRAT). The document provides the details on the methodology and main features of the FRAT. The tool manages the database of under-frequency events and calculates the frequency response baseline. Frequency response calculations are consistent with frequency response measure (FRM) in NERC BAL-003-1 for an interconnection and balancing authority. The FRAT can use both phasor measurement unit (PMU) data, where available, and supervisory control and data acquisition (SCADA) data. The tool is also capable of automatically generating NERC Frequency Response Survey (FRS) forms required by BAL-003-1 Standard.

  4. Method of detecting system function by measuring frequency response

    DOE Patents [OSTI]

    Morrison, John L. (Butte, MT); Morrison, William H. (Manchester, CT); Christophersen, Jon P. (Idaho Falls, ID)

    2012-04-03T23:59:59.000Z

    Real-time battery impedance spectrum is acquired using a one-time record. Fast Summation Transformation (FST) is a parallel method of acquiring a real-time battery impedance spectrum using a one-time record that enables battery diagnostics. An excitation current to a battery is a sum of equal amplitude sine waves of frequencies that are octave harmonics spread over a range of interest. A sample frequency is also octave and harmonically related to all frequencies in the sum. The time profile of this signal has a duration that is a few periods of the lowest frequency. The voltage response of the battery, average deleted, is the impedance of the battery in the time domain. Since the excitation frequencies are known and octave and harmonically related, a simple algorithm, FST, processes the time record by rectifying relative to the sine and cosine of each frequency. Another algorithm yields real and imaginary components for each frequency.

  5. Model Predictive Control of Regulation Services from Commercial Buildings to the Smart Grid

    E-Print Network [OSTI]

    Maasoumy, Mehdi

    2014-01-01T23:59:59.000Z

    Services from Commercial Buildings to the Smart Grid Mehdicommercial building hvac fan as ancillary service for smartbuildings flexibility can be utilized for frequency regulation provision in the smart

  6. Systems theory of Smad signaling

    E-Print Network [OSTI]

    D. C. Clarke; M. D. Betterton; X. Liu

    2006-03-22T23:59:59.000Z

    Transforming Growth Factor-beta (TGF-beta) signalling is an important regulator of cellular growth and differentiation. The principal intracellular mediators of TGF-beta signalling are the Smad proteins, which upon TGF-beta stimulation accumulate in the nucleus and regulate transcription of target genes. To investigate the mechanisms of Smad nuclear accumulation, we developed a simple mathematical model of canonical Smad signalling. The model was built using both published data and our experimentally determined cellular Smad concentrations (isoforms 2, 3, and 4). We found in mink lung epithelial cells that Smad2 (8.5-12 x 10^4 molecules/cell) was present in similar amounts to Smad4 (9.3-12 x 10^4 molecules/cell), while both were in excess of Smad3 (1.1-2.0 x 10^4 molecules/cell). Variation of the model parameters and statistical analysis showed that Smad nuclear accumulation is most sensitive to parameters affecting the rates of RSmad phosphorylation and dephosphorylation and Smad complex formation/dissociation in the nucleus. Deleting Smad4 from the model revealed that rate-limiting phospho-R-Smad dephosphorylation could be an important mechanism for Smad nuclear accumulation. Furthermore, we observed that binding factors constitutively localised to the nucleus do not efficiently mediate Smad nuclear accumulation if dephosphorylation is rapid. We therefore conclude that an imbalance in the rates of R-Smad phosphorylation and dephosphorylation is likely an important mechanism of Smad nuclear accumulation during TGF-beta signalling.

  7. Regulation of Drosophila eye development by the transcription factors : eyes absent and Spenito

    E-Print Network [OSTI]

    Jemc, Jennifer Colleen

    2007-01-01T23:59:59.000Z

    During development of an adult organism from a fertilized embryo, signaling pathways are deployed reiteratively to regulate a variety of cellular processes, including cell proliferation, specification, differentiation, ...

  8. Multipactor theory for multicarrier signals

    SciTech Connect (OSTI)

    Anza, S.; Vicente, C.; Gil, J. [Aurora Software and Testing S.L., Edificio de Desarrollo Empresarial 9B, Universidad Politecnica de Valencia, Camino de Vera s/n, 46022 Valencia (Spain); Mattes, M. [Laboratory of Electromagnetics and Acoustics (LEMA), Ecole Polytechnique Federale de Lausanne (EPFL), P.O. Box Station 11, Office ELB 017, CH-1015 Lausanne (Switzerland); Raboso, D. [Payloads Systems Division, European Space Agency, 2200-AG Noordwijk (Netherlands); Boria, V. E. [Departamento de Comunicaciones-iTEAM, Universidad Politecnica de Valencia Camino de Vera s/n, 46022 Valencia (Spain); Gimeno, B. [Departamento de Fisica Aplicada y Electromagnetismo-ICMUV, Universitat de Valencia, c/Dr. Moliner 50, 46100 Valencia (Spain)

    2011-03-15T23:59:59.000Z

    This work presents a new theory of multipactor under multicarrier signals for parallel-plate geometries, assuming a homogeneous electric field and one-dimensional electron motion. It is the generalization of the nonstationary multipactor theory for single-carrier signals [S. Anza et al.,Phys. Plasmas 17, 062110 (2010)]. It is valid for multicarrier signals with an arbitrary number of carriers with different amplitude, arbitrary frequency, and phase conditions and for any material coating. This new theory is able to model the real dynamics of the electrons during the multipactor discharge for both single and double surface interactions. Among other parameters of the discharge, it calculates the evolution in time of the charge growth, electron absorption, and creation rates as well as the instantaneous secondary emission yield and order. An extensive set of numerical tests with particle-in-cell software has been carried out in order to validate the theory under many different conditions. This theoretical development constitutes the first multipactor theory which completely characterizes the multipactor discharge for arbitrary multicarrier signals, setting the first step for further investigations in the field.

  9. Modelling regulations Completing an incomplete regulation

    E-Print Network [OSTI]

    van der Torre, Leon

    Objectives Modelling regulations Completing an incomplete regulation Examples Discussion Consistency and Completeness of Regulations Laurence Cholvy1 St´ephanie Roussel1,2 1ONERA Centre de Toulouse 2ISAE, Toulouse NorMAS 2008, Luxembourg, July 2008 cholvy Consistency and Completeness of Regulations

  10. Methods and apparatuses using filter banks for multi-carrier spread-spectrum signals

    DOE Patents [OSTI]

    Moradi, Hussein; Farhang, Behrouz; Kutsche, Carl A

    2014-10-14T23:59:59.000Z

    A transmitter includes a synthesis filter bank to spread a data symbol to a plurality of frequencies by encoding the data symbol on each frequency, apply a common pulse-shaping filter, and apply gains to the frequencies such that a power level of each frequency is less than a noise level of other communication signals within the spectrum. Each frequency is modulated onto a different evenly spaced subcarrier. A demodulator in a receiver converts a radio frequency input to a spread-spectrum signal in a baseband. A matched filter filters the spread-spectrum signal with a common filter having characteristics matched to the synthesis filter bank in the transmitter by filtering each frequency to generate a sequence of narrow pulses. A carrier recovery unit generates control signals responsive to the sequence of narrow pulses suitable for generating a phase-locked loop between the demodulator, the matched filter, and the carrier recovery unit.

  11. Methods and apparatuses using filter banks for multi-carrier spread-spectrum signals

    DOE Patents [OSTI]

    Moradi, Hussein; Farhang, Behrouz; Kutsche, Carl A

    2014-05-20T23:59:59.000Z

    A transmitter includes a synthesis filter bank to spread a data symbol to a plurality of frequencies by encoding the data symbol on each frequency, apply a common pulse-shaping filter, and apply gains to the frequencies such that a power level of each frequency is less than a noise level of other communication signals within the spectrum. Each frequency is modulated onto a different evenly spaced subcarrier. A demodulator in a receiver converts a radio frequency input to a spread-spectrum signal in a baseband. A matched filter filters the spread-spectrum signal with a common filter having characteristics matched to the synthesis filter bank in the transmitter by filtering each frequency to generate a sequence of narrow pulses. A carrier recovery unit generates control signals responsive to the sequence of narrow pulses suitable for generating a phase-locked loop between the demodulator, the matched filter, and the carrier recovery unit.

  12. Stabilized radio frequency quadrupole

    DOE Patents [OSTI]

    Lancaster, Henry D. (Orinda, CA); Fugitt, Jock A. (Berkeley, CA); Howard, Donald R. (Danville, CA)

    1984-01-01T23:59:59.000Z

    A long-vane stabilized radio frequency resonator for accelerating charged particles and including means defining a radio frequency resonator cavity, a plurality of long vanes mounted in the defining means for dividing the cavity into sections, and means interconnecting opposing ones of the plurality of vanes for stabilizing the resonator.

  13. Microfabricated ion frequency standard

    SciTech Connect (OSTI)

    Schwindt, Peter (Albuquerque, NM); Biedermann, Grant (Albuquerque, NM); Blain, Matthew G. (Albuquerque, NM); Stick, Daniel L. (Albuquerque, NM); Serkland, Darwin K. (Albuquerque, NM); Olsson, III, Roy H. (Albuquerque, NM)

    2010-12-28T23:59:59.000Z

    A microfabricated ion frequency standard (i.e. an ion clock) is disclosed with a permanently-sealed vacuum package containing a source of ytterbium (Yb) ions and an octupole ion trap. The source of Yb ions is a micro-hotplate which generates Yb atoms which are then ionized by a ultraviolet light-emitting diode or a field-emission electron source. The octupole ion trap, which confines the Yb ions, is formed from suspended electrodes on a number of stacked-up substrates. A microwave source excites a ground-state transition frequency of the Yb ions, with a frequency-doubled vertical-external-cavity laser (VECSEL) then exciting the Yb ions up to an excited state to produce fluorescent light which is used to tune the microwave source to the ground-state transition frequency, with the microwave source providing a precise frequency output for the ion clock.

  14. Signal processor for processing ultrasonic receiver signals

    DOE Patents [OSTI]

    Fasching, George E. (Morgantown, WV)

    1980-01-01T23:59:59.000Z

    A signal processor is provided which uses an analog integrating circuit in conjunction with a set of digital counters controlled by a precision clock for sampling timing to provide an improved presentation of an ultrasonic transmitter/receiver signal. The signal is sampled relative to the transmitter trigger signal timing at precise times, the selected number of samples are integrated and the integrated samples are transferred and held for recording on a strip chart recorder or converted to digital form for storage. By integrating multiple samples taken at precisely the same time with respect to the trigger for the ultrasonic transmitter, random noise, which is contained in the ultrasonic receiver signal, is reduced relative to the desired useful signal.

  15. Signal and Image Processing with Sinlets

    E-Print Network [OSTI]

    Alexander Y. Davydov

    2012-09-17T23:59:59.000Z

    This paper presents a new family of localized orthonormal bases - sinlets - which are well suited for both signal and image processing and analysis. One-dimensional sinlets are related to specific solutions of the time-dependent harmonic oscillator equation. By construction, each sinlet is infinitely differentiable and has a well-defined and smooth instantaneous frequency known in analytical form. For square-integrable transient signals with infinite support, one-dimensional sinlet basis provides an advantageous alternative to the Fourier transform by rendering accurate signal representation via a countable set of real-valued coefficients. The properties of sinlets make them suitable for analyzing many real-world signals whose frequency content changes with time including radar and sonar waveforms, music, speech, biological echolocation sounds, biomedical signals, seismic acoustic waves, and signals employed in wireless communication systems. One-dimensional sinlet bases can be used to construct two- and higher-dimensional bases with variety of potential applications including image analysis and representation.

  16. Fact Sheet: Beacon Power 20 MW Flywheel Frequency Regulation...

    Office of Environmental Management (EM)

    flywheels, electrochemical capacitors, superconducting magnetic energy storage (SMES), power electronics, and control systems, visit the Energy Storage page. Beacon Power 20 MW...

  17. EA-1631: Beacon Power Corporation Frequency Regulation Facility in

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy China U.S.ContaminationJuly 2011D APPENDIX D9Construction and Operation of a

  18. Stability issues in IC Low Drop Out voltage regulators

    E-Print Network [OSTI]

    Chava, Krishna Chaitanya

    2002-01-01T23:59:59.000Z

    Performance issues of IC Low Drop Out (LDO) voltage regulators, with specific reference to stability, are discussed in this thesis. Evaluation of existing frequency compensation schemes and their performances across operating loads is presented...

  19. Signal Processing:Fourier Signal Processing:Fourier

    E-Print Network [OSTI]

    Rimon, Elon

    Signal Processing:Fourier #12;Signal Processing:Fourier Fourier methods · Continous signals FS ­ Fourier Series : Periodic FT ­ (Integral) Fourier Transform: Transients (aperiodic) ·Discrete (sampled) signals DFS ­Discrete Fourier Series DFT ­ Discrete Fourier Transform #12;Signal Processing:Fourier #12

  20. Compensated gain control circuit for buck regulator command charge circuit

    DOE Patents [OSTI]

    Barrett, David M. (Albuquerque, NM)

    1996-01-01T23:59:59.000Z

    A buck regulator command charge circuit includes a compensated-gain control signal for compensating for changes in the component values in order to achieve optimal voltage regulation. The compensated-gain control circuit includes an automatic-gain control circuit for generating a variable-gain control signal. The automatic-gain control circuit is formed of a precision rectifier circuit, a filter network, an error amplifier, and an integrator circuit.

  1. Compensated gain control circuit for buck regulator command charge circuit

    DOE Patents [OSTI]

    Barrett, D.M.

    1996-11-05T23:59:59.000Z

    A buck regulator command charge circuit includes a compensated-gain control signal for compensating for changes in the component values in order to achieve optimal voltage regulation. The compensated-gain control circuit includes an automatic-gain control circuit for generating a variable-gain control signal. The automatic-gain control circuit is formed of a precision rectifier circuit, a filter network, an error amplifier, and an integrator circuit. 5 figs.

  2. Active optical frequency standards using cold atoms: perspectives and challenges

    E-Print Network [OSTI]

    Kazakov, Georgy A

    2015-01-01T23:59:59.000Z

    We consider various approaches to the creation of a high-stability active optical frequency standard, where the atomic ensemble itself produces a highly stable and accurate frequency signal. The short-time frequency stability of such standards may overcome the stability of lasers stabilized to macroscopic cavities which are used as local oscillators in the modern optical frequency standard systems. The main idea is to create a "superradiant" laser operating deep in the bad cavity regime, where the decay rate of the cavity field significantly exceeds the decoherence rate of the lasing transition. Two main approaches towards the realization of an active optical frequency standard have been proposed already: the optical lattice laser, and the atomic beam laser. We consider these and some alternative approaches, and discuss the parameters for atomic ensembles necessary to attain the metrology relevant level of short-time frequency stability, and various effects and main challenges critical for practical implement...

  3. Design Considerations for Frequency Responsive Grid Friendly Appliances

    SciTech Connect (OSTI)

    Lu, Ning; Hammerstrom, Donald J.

    2006-05-24T23:59:59.000Z

    The paper addresses design considerations for frequency responsive Grid FriendlyTM appliances (FR-GFAs). Case studies have been done based on the frequency data collected in 2003 in Western Electricity Coordinating Council (WECC) systems. An FR-GFA can turn on/off based on frequency signals and make selective low-frequency load shedding possible at appliance level. FR-GFAs can also be treated as an spinning reserve to maintain a load-to-generation balance under power system normal operation states. The triggering frequency and duration of the FR-GFA device with different frequency setting schemes are simulated. Design considerations of the FR-GFA are then discussed based on simulation results.

  4. Variable Frequency Pump Drives

    E-Print Network [OSTI]

    Karassik, I. J.; Petraccaro, L. L.; McGuire, J. T.

    . In a conventional pump and driver arrangement (for example, a centrifugal pump coupled to an AC induction motor'with no speed control provision), the motor runs at. a constant speed, which is determined by the incoming line frequency, and the pump... when it is needed. LONG RANGE DESIGN TRENDS The growing use of variable-frequency electric motor drives will permit the integration of 60 and 50 cycle pump lines. One important concern for future improvements is the growing possibility...

  5. Regulation of Branching by Phytochrome and Phytohormones

    E-Print Network [OSTI]

    Krishnareddy, Srirama R.

    2012-07-16T23:59:59.000Z

    ratios (R:FR) perceived by phytochromes serve as a warning signal about impending competition for light resources and lead to shade avoidance responses (SARs), including reduced branching. The R:FR regulates branching in both a bud autonomous and non...

  6. Efficiency Defence, Administrative Fuzziness, and Commitment in Merger Regulation

    E-Print Network [OSTI]

    Feigon, Brooke

    Efficiency Defence, Administrative Fuzziness, and Commitment in Merger Regulation by Andrei: This paper develops a signalling model to look at some effects of the inclusion of an efficiency defence of parameters. May 2006 JEL Classification: K21; L44; L51 Keywords: Merger Regulation, Efficiency Defence

  7. California Energy Commission REGULATIONS

    E-Print Network [OSTI]

    California Energy Commission REGULATIONS FINAL STATEMENT OF REASONS ENFORCEMENT PROCEDURES by Government Code section 11346.9(a) for the California Energy Commission (Energy Commission) regulations 399.30 (l) directs the Energy Commission to adopt regulations specifying procedures

  8. California Energy Commission REGULATIONS

    E-Print Network [OSTI]

    California Energy Commission REGULATIONS NONRESIDENTIAL BUILDING ENERGY Disclosure Program California Code of Regulations Title 20. Public Utilities and Energy Division 2. State USE DISCLOSURE PROGRAM California Code of Regulations, Title 20, Division 2

  9. Signal sciences workshop proceedings

    SciTech Connect (OSTI)

    Candy, J.V.

    1997-05-01T23:59:59.000Z

    This meeting is aimed primarily at signal processing and controls. The technical program for the 1997 Workshop includes a variety of efforts in the Signal Sciences with applications in the Microtechnology Area a new program at LLNL and a future area of application for both Signal/Image Sciences. Special sessions organized by various individuals in Seismic and Optical Signal Processing as well as Micro-Impulse Radar Processing highlight the program, while the speakers at the Signal Processing Applications session discuss various applications of signal processing/control to real world problems. For the more theoretical, a session on Signal Processing Algorithms was organized as well as for the more pragmatic, featuring a session on Real-Time Signal Processing.

  10. Modelling the influence of RKIP on the ERK signalling pathway using the stochastic process

    E-Print Network [OSTI]

    Calder, Muffy

    Modelling the influence of RKIP on the ERK signalling pathway using the stochastic process algebra Regulated Kinase (ERK) signalling pathway [5] through modelling in a Markovian process algebra, PEPA [11 durations and probabilistic choices. The system which we consider is the Ras/Raf-1/MEK/ERK signalling

  11. Cellular/Molecular ERK1/ERK2 MAPK Signaling is Required to Increase Myelin

    E-Print Network [OSTI]

    Cellular/Molecular ERK1/ERK2 MAPK Signaling is Required to Increase Myelin Thickness Independent for two important signaling molecules, extracelluar signal-regulated protein kinases 1 and 2 (ERK1/ERK2 generated and analyzed two lines of mice lacking both ERK1/ERK2 function specifically in oligodendrocyte

  12. Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions

    E-Print Network [OSTI]

    Timmer, Jens

    Theoretical and experimental analysis links isoform- specific ERK signalling to cell fate decisions of signalling pathways such as the extracellular signal-regulated kinase (ERK) cascade, but contributions with mathematical modelling, we predicted and experimentally confirmed a distributive ERK phosphorylation mechanism

  13. Modelling the Influence of RKIP on the ERK Signalling Pathway Using the Stochastic Process

    E-Print Network [OSTI]

    Swain, Peter

    Modelling the Influence of RKIP on the ERK Signalling Pathway Using the Stochastic Process Algebra the influence of the Raf Kinase In- hibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK durations and probabilistic choices. The system which we consider is the Ras/Raf-1/MEK/ERK signalling

  14. ITERATIVELY REWEIGHTED DESIGN OF OVERSAMPLING COMPLEX-MODULATED FILTER-BANKS FOR HIGH OUTPUT-SIGNAL QUALITY

    E-Print Network [OSTI]

    Göckler, Heinz G.

    of the frequency-dependent signal-to- disturbance ratio. Next, in section 3, we discuss the basic idea of the of the signal-to-disturbance ratio of the output-signal of an oversampling, complex-modulated subband-coder filter-bank pair with extensive subband-signal am- plification. The undesired non-linear disturbance

  15. Integrated Power Management of Data Centers and Electric Vehicles for Energy and Regulation Market

    E-Print Network [OSTI]

    Zhang, Wei

    regulation signal, as well as developing a market planning strat- egy that determines the best baseload. The proposed framework is evaluated base on real workload, regulation signal, and market data. The simulation.edu, brocanelli.1@osu.edu, zhang@ece.osu.edu, xwang@ece.osu.edu B(m) Overall baseload of servers, UPS and PEVs

  16. Mechanisms of regulation in the interferon factor 3 (IRF- 3) pathway

    E-Print Network [OSTI]

    Limmer, Kirsten

    2008-01-01T23:59:59.000Z

    Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factorCutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor

  17. Forest Road Building Regulations

    Broader source: Energy.gov [DOE]

    The Wisconsin Department of Natural Resources has regulations for building a forest road, if development requires one. Regulations include zoning ordinances and permits for stream crossing, grading...

  18. A Robust Iterative Unfolding Method for Signal Processing

    E-Print Network [OSTI]

    András László

    2006-01-09T23:59:59.000Z

    There is a well-known series expansion (Neumann series) in functional analysis for perturbative inversion of specific operators on Banach spaces. However, operators that appear in signal processing (e.g. folding and convolution of probability density functions), in general, do not satisfy the usual convergence condition of that series expansion. This article provides some theorems on the convergence criteria of a similar series expansion for this more general case, which is not covered yet by the literature. The main result is that a series expansion provides a robust unbiased unfolding and deconvolution method. For the case of the deconvolution, such a series expansion can always be applied, and the method always recovers the maximum possible information about the initial probability density function, thus the method is optimal in this sense. A very significant advantage of the presented method is that one does not have to introduce ad hoc frequency regulations etc., as in the case of usual naive deconvolution methods. For the case of general unfolding problems, we present a computer-testable sufficient condition for the convergence of the series expansion in question. Some test examples and physics applications are also given. The most important physics example shall be (which originally motivated our survey on this topic) the case of pi^0 --> gamma+gamma particle decay: we show that one can recover the initial pi^0 momentum density function form the measured single gamma momentum density function by our series expansion.

  19. Radio frequency coupling apparatus and method for measuring minority carrier lifetimes in semiconductor materials

    DOE Patents [OSTI]

    Johnston, Steven W. (Golden, CO); Ahrenkiel, Richard K. (Lakewood, CO)

    2002-01-01T23:59:59.000Z

    An apparatus for measuring the minority carrier lifetime of a semiconductor sample using radio-frequency coupling. The measuring apparatus includes an antenna that is positioned a coupling distance from a semiconductor sample which is exposed to light pulses from a laser during sampling operations. A signal generator is included to generate high frequency, such as 900 MHz or higher, sinusoidal waveform signals that are split into a reference signal and a sample signal. The sample signal is transmitted into a sample branch circuit where it passes through a tuning capacitor and a coaxial cable prior to reaching the antenna. The antenna is radio-frequency coupled with the adjacent sample and transmits the sample signal, or electromagnetic radiation corresponding to the sample signal, to the sample and receives reflected power or a sample-coupled-photoconductivity signal back. To lower impedance and speed system response, the impedance is controlled by limiting impedance in the coaxial cable and the antenna reactance. In one embodiment, the antenna is a waveguide/aperture hybrid antenna having a central transmission line and an adjacent ground flange. The sample-coupled-photoconductivity signal is then transmitted to a mixer which also receives the reference signal. To enhance the sensitivity of the measuring apparatus, the mixer is operated to phase match the reference signal and the sample-coupled-photoconductivity signal.

  20. Matching the waveform and the temporal window in the creation of experimental signals

    E-Print Network [OSTI]

    to a discrete-frequency representation in which the Fourier transform of the windowed signal preserves" wherein the power spectrum acquires power outside the frequency band of the original waveform. The spectrum be- comes a continuum with all frequencies, inside and outside the waveform band, represented more

  1. Single-sideband hybrid AM-PM signal models

    E-Print Network [OSTI]

    Painter, John H.

    demodulation reference. The doubling process, which exhibits a sharp threshold effect, is not necessary when the hybrid AM-PM signal is employed. Possibilities for future effort are Seen in combining various of the eight signals to obtain multiple data... for their valuable contributions. Single-Sideband Hybrid AM-PM Signal Models The purpose of this letter is to disclose eight unique, nontrivial models for a hybrid AM-PM signal modulated by a single sinusoid and having a one-sided frequency spectrum...

  2. UNIVERSITY STANDARDS AND REGULATIONS

    E-Print Network [OSTI]

    Royer, Dana

    2014­2015 UNIVERSITY STANDARDS AND REGULATIONS #12;Wesleyan University does not discriminate STANDARDS OF CONDUCT

  3. UNIVERSITY STANDARDS AND REGULATIONS

    E-Print Network [OSTI]

    Royer, Dana

    2013­2014 UNIVERSITY STANDARDS AND REGULATIONS #12;Wesleyan University does not discriminate STANDARDS OF CONDUCT

  4. Perlecan regulation of sonic hedgehog signaling: from drosophila to humans

    E-Print Network [OSTI]

    Hernandez, Ana Maria

    2009-05-15T23:59:59.000Z

    Prostate cancer is the second leading cause of death from cancer in men in the United States. Most men will die of the advanced, metastatic form of the disease. Thus, treatment strategies targeting the metastatic form of the disease are especially...

  5. Regulation of cellular signaling pathways by endocytosis and protein degradation

    E-Print Network [OSTI]

    Windler, Sarah

    2010-01-01T23:59:59.000Z

    but dispensable for degradation. Dev. Cell. 2, 209-219. 40.Role for Slimb in the degradation of Drosophila Periodby targeting RhoA for degradation. Science 5651, 1775-1779.

  6. IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans

    E-Print Network [OSTI]

    Nagy, Anikó I.; Vázquez-Manrique, Rafael P.; Lopez, Marie; Christov, Christo; Sequedo, María Dolores; Herzog, Mareike; Herlihy, Anna E; Bodak, Maxime; Gatsi, Roxani; Baylis, Howard A.

    2015-01-21T23:59:59.000Z

    second messenger in animals. IP3 is generated by the action of phospholipase C (PLC) in response to a diverse range of extracellular stimuli, including neurotransmitters and hormones acting on G-protein or tyrosine kinase coupled receptors (Fig 1A). IP... to deplete GFP expressed in the body wall muscles using a myo-3p::GFP construct [30, 31] again itr-1 mutants show an increased effect (Fig 1I). PLC-? / EGL-8 mutants show increased RNAi responses IP3 is produced from phosphatidylinositol 4...

  7. Plastid Regulation of Lhcb1 Transcription in the Chlorophyte Alga Dunaliella tertiolecta1

    E-Print Network [OSTI]

    , and by following the kinetic pattern of gene regulation, we infer two different sensors in the signal transduction to be a critical determinant of gene expression, whereas on time scales of 8 h or longer, the redox state. The regulation of these elements allows the cell to up- or down-regulate the expression on Lhcb1 in response

  8. Regulation of flowering time in Arabidopsis by K homology domain proteins

    E-Print Network [OSTI]

    Lin, Chentao

    Regulation of flowering time in Arabidopsis by K homology domain proteins Todd C. Mockler* , Xuhong to reproductive develop- ment in Arabidopsis is regulated by multiple floral induction pathways, including to regulate the expression of a small set of genes critical for floral initiation and different signal

  9. Trade-offs in signalling components differ with signalling effort

    E-Print Network [OSTI]

    Bertram, Sue

    ARTICLES Trade-offs in signalling components differ with signalling effort SUSAN M. BERTRAM on signal components, males that signal often might be forced to make trade-offs among these signalling limitations. We explored the conditions under which males make trade-offs among components of signalling

  10. Frequency Control Performance Measurement and Requirements

    E-Print Network [OSTI]

    Illian, Howard F.

    2011-01-01T23:59:59.000Z

    DCS only measured low-frequency disturbances instead of bothlow- and high-frequency disturbances. The DCS requiredof the pre-disturbance frequency and the settling frequency.

  11. A high frequency resonance gravity gradiometer

    SciTech Connect (OSTI)

    Bagaev, S. N.; Kvashnin, N. L.; Skvortsov, M. N. [Laser Physics Institute SB RAS, Novosibirsc (Russian Federation); Bezrukov, L. B.; Krysanov, V. A. [Institute of Nuclear Physics RAS, Moscow (Russian Federation); Oreshkin, S. I.; Motylev, A. M.; Popov, S. M.; Samoilenko, A. A.; Yudin, I. S. [Lomonosov MSU, Sternberg Astronomical Institute, Moscow (Russian Federation); Rudenko, V. N. [Institute of Nuclear Physics RAS, Moscow (Russian Federation); Lomonosov MSU, Sternberg Astronomical Institute, Moscow (Russian Federation)

    2014-06-15T23:59:59.000Z

    A new setup OGRAN—the large scale opto-acoustical gravitational detector is described. As distinguished from known gravitational bar detectors it uses the optical interferometrical readout for registering weak variations of gravity gradient at the kilohetz frequency region. At room temperature, its sensitivity is limited only by the bar Brownian noise at the bandwidth close to 100 Hz. It is destined for a search for rare events—gravitational pulses coincident with signals of neutrino scintillator (BUST) in the deep underground of Baksan Neutrino Observatory of INR RAS.

  12. Molecular Cell Frequency-Modulated Pulses of ERK Activity

    E-Print Network [OSTI]

    Albeck, John

    Molecular Cell Article Frequency-Modulated Pulses of ERK Activity Transmit Quantitative://dx.doi.org/10.1016/j.molcel.2012.11.002 SUMMARY The EGF-stimulated ERK/MAPK pathway is a key conduit and the response curve relating signal output to prolifer- ation. Under steady-state conditions, we find that ERK

  13. Highly Strained Compliant Optical Metamaterials with Large Frequency

    E-Print Network [OSTI]

    Atwater, Harry

    of a metamaterial in the near-infrared by changing the distances and thus the coupling strength between pairs, we demonstrate dynamic surface-enhanced infrared absorption by tuning the metamaterial resonant frequency through a CH stretch vibrational mode, enhancing the reflection signal by a factor of 180

  14. 442 IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS, VOL. 35, NO. 2, MARCH/APRIL 1999 An Adaptive Statistical TimeFrequency Method

    E-Print Network [OSTI]

    Yazici, Birsen

    Statistical Time­Frequency Method for Detection of Broken Bars and Bearing Faults in Motors Using Stator signal processing methods have provided efficient and optimal tools to process nonstationary signals

  15. Method and apparatus for sensing the natural frequency of a cantilevered body

    DOE Patents [OSTI]

    Duncan, Michael G. (Clinton, TN)

    2000-01-01T23:59:59.000Z

    A method and apparatus for measuring the natural resonant frequency of a spring element by monitoring a phase difference between an output signal from the spring element and an input signal to the spring element and by adjusting frequency of the input signal until a detected phase difference signals that the natural resonant frequency has been reached. The method and apparatus are applied to a micro-cantilevered elements used to measure gas compositions and concentrations. Such elements are provided with coatings that absorb gas to cause deflections and changes in the mass or spring constant of the cantilevered element. These changes correspond to changes in the natural resonant frequency of the cantilevered element which are measured using the method and apparatus described herein.

  16. High frequency reference electrode

    DOE Patents [OSTI]

    Kronberg, J.W.

    1994-05-31T23:59:59.000Z

    A high frequency reference electrode for electrochemical experiments comprises a mercury-calomel or silver-silver chloride reference electrode with a layer of platinum around it and a layer of a chemically and electrically resistant material such as TEFLON around the platinum covering all but a small ring or halo' at the tip of the reference electrode, adjacent to the active portion of the reference electrode. The voltage output of the platinum layer, which serves as a redox electrode, and that of the reference electrode are coupled by a capacitor or a set of capacitors and the coupled output transmitted to a standard laboratory potentiostat. The platinum may be applied by thermal decomposition to the surface of the reference electrode. The electrode provides superior high-frequency response over conventional electrodes. 4 figs.

  17. HVDC control system based on parallel digital signal processors

    SciTech Connect (OSTI)

    Maharsi, Y.; Do, V.Q.; Sood, V.K.; Casoria, S.; Belanger, J. [Hydro-Quebec, Varennes, Quebec (Canada)] [Hydro-Quebec, Varennes, Quebec (Canada)

    1995-05-01T23:59:59.000Z

    A numerical HVDC control system operating in real time has been developed for a simulator to be used for operator training. The control system, implemented with digital signal processors (DSPs), consists of typical HVDC control functions such as the synchronizing unit, the regulation unit, the protection unit, the firing unit, the tap changer and the reactive power regulation unit. Results from the steady-state and the transient performance validation tests carried out on the IREQ power system simulator are provided.

  18. Fast radio-frequency amplitude modulation in multiple-quantum magic-angle-spinning nuclear magnetic resonance: Theory and experiments

    E-Print Network [OSTI]

    Frydman, Lucio

    Fast radio-frequency amplitude modulation in multiple-quantum magic-angle-spinning nuclear magnetic of this experiment has been the poor efficiency of the radio-frequency pulses used in converting multiple-modulated radio-frequency pulses, and which can yield substantial signal and even resolution enhancements over

  19. Optimized Sampling Frequencies for Weld Reliability Assessments of Long Pipeline Segments

    E-Print Network [OSTI]

    Kreinovich, Vladik

    p. If this probability exceeds a certain regulated (small) threshold p 0 , the pipeline must. To be on the safe side, regulations require that a pipeline be repaired when it is possible that p â?? p 0 , iOptimized Sampling Frequencies for Weld Reliability Assessments of Long Pipeline Segments Cesar J

  20. Optimized Sampling Frequencies for Weld Reliability Assessments of Long Pipeline Segments

    E-Print Network [OSTI]

    Kreinovich, Vladik

    p. If this probability exceeds a certain regulated (small) threshold p0, the pipeline must. To be on the safe side, regulations require that a pipeline be repaired when it is possible that p p0, i.e., when pOptimized Sampling Frequencies for Weld Reliability Assessments of Long Pipeline Segments Cesar J

  1. Fractional frequency instability in the 10{sup -14} range with a thermal beam optical frequency reference

    SciTech Connect (OSTI)

    McFerran, John J.; Luiten, Andre N. [School of Physics, University of Western Australia, 35 Stirling Highway, Crawley 6009, W.A. (Australia)

    2010-02-15T23:59:59.000Z

    We demonstrate a means of increasing the signal-to-noise ratio in a Ramsey-Borde interferometer with spatially separated oscillatory fields on a thermal atomic beam. The {sup 1}S{sub 0}{r_reversible}{sup 3}P{sub 1} intercombination line in neutral {sup 40}Ca is used as a frequency discriminator, with an extended cavity diode laser at 423 nm probing the ground state population after a Ramsey-Borde sequence of 657 nm light-field interactions with the atoms. Evaluation of the instability of the Ca frequency reference is carried out by comparison with (i) a hydrogen-maser and (ii) a cryogenic sapphire oscillator. In the latter case the Ca reference exhibits a square-root {Lambda} variance of 9.2x10{sup -14} at 1 s and 2.0x10{sup -14} at 64 s. This is an order-of-magnitude improvement for optical beam frequency references, to our knowledge. The shot noise of the readout fluorescence produces a limiting square-root {Lambda} variance of 7x10{sup -14}/{radical}({tau}), highlighting the potential for improvement. This work demonstrates the feasibility of a portable frequency reference in the optical domain with 10{sup -14} range frequency instability.

  2. The Self-Limiting Dynamics of TGF-? Signaling In Silico and In Vitro, with Negative Feedback through PPM1A Upregulation

    E-Print Network [OSTI]

    Wang, Junjie

    The TGF-?/Smad signaling system decreases its activity through strong negative regulation. Several molecular mechanisms of negative regulation have been published, but the relative impact of each mechanism on the overall ...

  3. Design and Stability of Load-Side Primary Frequency Control in Power Systems

    E-Print Network [OSTI]

    Low, Steven H.

    1 Design and Stability of Load-Side Primary Frequency Control in Power Systems Changhong Zhao for primary frequency regulation in power networks, by formulating an optimal load control (OLC) problem where--We present a systematic method to design ubiqui- tous continuous fast-acting distributed load control

  4. Natural Gas Regulations (Kentucky)

    Broader source: Energy.gov [DOE]

    Kentucky Administrative Regulation title 805 promulgates the rules and regulations pertaining to natural gas production in Kentucky. In addition to KAR title 405, chapter 30, which pertains to any...

  5. Radio frequency phototube

    DOE Patents [OSTI]

    Margaryan, Amur (Yerevan, AM); Gynashyan, Karlen (Yerevan, AM); Hashimoto, Osamu (Sendai, JP); Majewski, Stanislaw (Morgantown, WV); Tang, Linguang (Yorktown, VA); Marikyan, Gagik (Yerevan, AM); Marikyan, legal representative, Lia (Yerevan, AM)

    2012-03-20T23:59:59.000Z

    A method and apparatus of obtaining a record of repetitive optical or other phenomena having durations in the picosecond range, comprising a circular scan electron tube to receive light pulses and convert them to electron images consisting with fast nanosecond electronic signals, a continuous wave light or other particle pulses, e.g. electron picosecond pulses, and a synchronizing mechanism arranged to synchronize the deflection of the electron image (images) in the tube (tubes) with the repetition rate of the incident pulse train. There is also provided a method and apparatus for digitization of a repetitive and random optical waveform with a bandwidth higher than 10 GHz.

  6. Firewater system inadvertent actuation frequencies

    SciTech Connect (OSTI)

    Schroeder, J.A. [EG and G Idaho, Inc., Idaho Falls, ID (United States); Eide, S.A. [Los Alamos Technical Associates, Inc., Albuquerque, NM (United States)

    1993-04-01T23:59:59.000Z

    This paper presents some recommended generic values for fire protection system inadvertent actuation frequencies. The frequencies are based on actual data from Department of Energy and commercial reactor plant facilities.

  7. Firewater system inadvertent actuation frequencies

    SciTech Connect (OSTI)

    Schroeder, J.A. (EG and G Idaho, Inc., Idaho Falls, ID (United States)); Eide, S.A. (Los Alamos Technical Associates, Inc., Albuquerque, NM (United States))

    1993-01-01T23:59:59.000Z

    This paper presents some recommended generic values for fire protection system inadvertent actuation frequencies. The frequencies are based on actual data from Department of Energy and commercial reactor plant facilities.

  8. Damage mechanisms identification of polymer based composite materials: time-frequency investigation of

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Damage mechanisms identification of polymer based composite materials: time-frequency investigation 2012, Nantes, France 2045 #12;Presented in this paper, a time-frequency damage characterization Emission (AE) signals by the Hilbert-Huang transform (HHT). It is to be noted that the study of damage

  9. Computer Use Regulation Introduction

    E-Print Network [OSTI]

    Liu, Paul

    Computer Use Regulation #12;Introduction · The following training materials will reference the contents of the Computer Use Regulations, but should not serve as a substitute for reading the actual responsibilities NCSU employees have under the regulations. · North Carolina State University's computer networks

  10. Emotion Regulation CONCEPTUAL FOUNDATIONS

    E-Print Network [OSTI]

    Gross, James J.

    CHAPTER 1 Emotion Regulation CONCEPTUAL FOUNDATIONS JAMES J. GROSS ROSS A. THOMPSON Standing, paper or plastic are made. Quotidian acts of emotion regulation such as this constitute one important- changes that require us to regulate how emotions are experienced and expressed. But what do people do

  11. 3 Library Regulations Definitions

    E-Print Network [OSTI]

    Mottram, Nigel

    3 Library Regulations Definitions In Regulation 3: 'Library' means the University Library as defined in Regulation 3.1; 'Library staff' means the staff of the University Library; 'Librarian' means the University Librarian and Head of Information Resources Directorate or nominee; `Library Committee' means

  12. Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs

    E-Print Network [OSTI]

    Babu, M. Madan

    31st Jan 2011 Intrinsically Disordered Proteins: Regulation and Disease Regulation of IDPs M. Madan ...........................................................................................................................................................................1 2. The need for regulating IDPs.................................................................................................................................................1 3. General principles of IDP regulation

  13. Load regulating expansion fixture

    DOE Patents [OSTI]

    Wagner, Lawrence M. (San Jose, CA); Strum, Michael J. (San Jose, CA)

    1998-01-01T23:59:59.000Z

    A free standing self contained device for bonding ultra thin metallic films, such as 0.001 inch beryllium foils. The device will regulate to a predetermined load for solid state bonding when heated to a bonding temperature. The device includes a load regulating feature, whereby the expansion stresses generated for bonding are regulated and self adjusting. The load regulator comprises a pair of friction isolators with a plurality of annealed copper members located therebetween. The device, with the load regulator, will adjust to and maintain a stress level needed to successfully and economically complete a leak tight bond without damaging thin foils or other delicate components.

  14. Load regulating expansion fixture

    DOE Patents [OSTI]

    Wagner, L.M.; Strum, M.J.

    1998-12-15T23:59:59.000Z

    A free standing self contained device for bonding ultra thin metallic films, such as 0.001 inch beryllium foils is disclosed. The device will regulate to a predetermined load for solid state bonding when heated to a bonding temperature. The device includes a load regulating feature, whereby the expansion stresses generated for bonding are regulated and self adjusting. The load regulator comprises a pair of friction isolators with a plurality of annealed copper members located therebetween. The device, with the load regulator, will adjust to and maintain a stress level needed to successfully and economically complete a leak tight bond without damaging thin foils or other delicate components. 1 fig.

  15. Research Article Signaling Threat

    E-Print Network [OSTI]

    Gross, James J.

    Research Article Signaling Threat How Situational Cues Affect Women in Math, Science and organization,canmake potentialtargetsvulnerabletosocial identity threat.Objective and subjective measuresofidentity threat were collected from male and female math, science, and engineering (MSE) majors who watched

  16. Liquidity facilities and signaling

    E-Print Network [OSTI]

    Arregui, Nicolás

    2010-01-01T23:59:59.000Z

    This dissertation studies the role of signaling concerns in discouraging access to liquidity facilities like the IMF contingent credit lines (CCL) and the Discount Window (DW). In Chapter 1, I analyze the introduction of ...

  17. Frequency mixing crystal

    DOE Patents [OSTI]

    Ebbers, Christopher A. (Livermore, CA); Davis, Laura E. (Manteca, CA); Webb, Mark (Salida, CA)

    1992-01-01T23:59:59.000Z

    In a laser system for converting infrared laser light waves to visible light comprising a source of infrared laser light waves and means of harmoic generation associated therewith for production of light waves at integral multiples of the frequency of the original wave, the improvement of said means of harmonic generation comprising a crystal having the chemical formula X.sub.2 Y(NO.sub.3).sub.5 .multidot.2 nZ.sub.2 o wherein X is selected from the group consisting of Li, Na, K, Rb, Cs, and Tl; Y is selected from the group consisting of Sc, Y, La, Ce, Nd, Pr, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Al, Ga, and In; Z is selected from the group consisting of H and D; and n ranges from 0 to 4.

  18. High frequency nanotube oscillator

    DOE Patents [OSTI]

    Peng, Haibing (Houston, TX); Zettl, Alexander K. (Kensington, TX)

    2012-02-21T23:59:59.000Z

    A tunable nanostructure such as a nanotube is used to make an electromechanical oscillator. The mechanically oscillating nanotube can be provided with inertial clamps in the form of metal beads. The metal beads serve to clamp the nanotube so that the fundamental resonance frequency is in the microwave range, i.e., greater than at least 1 GHz, and up to 4 GHz and beyond. An electric current can be run through the nanotube to cause the metal beads to move along the nanotube and changing the length of the intervening nanotube segments. The oscillator can operate at ambient temperature and in air without significant loss of resonance quality. The nanotube is can be fabricated in a semiconductor style process and the device can be provided with source, drain, and gate electrodes, which may be connected to appropriate circuitry for driving and measuring the oscillation. Novel driving and measuring circuits are also disclosed.

  19. Frequency doubling crystals

    DOE Patents [OSTI]

    Wang, Francis (Danville, CA); Velsko, Stephan P. (Livermore, CA)

    1989-01-01T23:59:59.000Z

    A systematic approach to the production of frequency conversion crystals is described in which a chiral molecule has attached to it a "harmonic generating unit" which contributes to the noncentrosymmetry of the molecule. Certain preferred embodiments of such harmonic generating units include carboxylate, guanadyly and imidazolyl units. Certain preferred crystals include L-arginine fluoride, deuterated L-arginine fluoride, L-arginine chloride monohydrate, L-arginine acetate, dithallium tartrate, ammonium N-acetyl valine, N-acetyl tyrosine and N-acetyl hydroxyproline. Chemical modifications of the chiral molecule, such as deuteration, halogenation and controlled counterion substitution are available to adapt the dispersive properties of a crystal in a particular wavelength region.

  20. Demonstration of coherent time-frequency Schmidt mode selection using dispersion-engineered frequency conversion

    E-Print Network [OSTI]

    Benjamin Brecht; Andreas Eckstein; Raimund Ricken; Viktor Quiring; Hubertus Suche; Linda Sansoni; Christine Silberhorn

    2014-09-16T23:59:59.000Z

    Time-frequency Schmidt (TFS) modes of ultrafast quantum states are naturally compatible with high bit-rate integrated quantum communication networks. Thus they offer an attractive alternative for the realization of high dimensional quantum optics. Here, we present a quantum pulse gate based on dispersion-engineered ultrafast frequency conversion in a nonlinear optical waveguide, which is a key element for harnessing the potential of TFS modes. We experimentally retrieve the modal spectral-temporal structure of our device and demonstrate a single-mode operation fidelity of 80\\%, which is limited by experimental shortcomings. In addition, we retrieve a conversion efficiency of 87.7\\% with a high signal-to-noise ratio of 8.8 when operating the quantum pulse gate at the single-photon level.

  1. System and method for detection of dispersed broadband signals

    DOE Patents [OSTI]

    Qian, Shie (Austin, TX); Dunham, Mark E. (Los Alamos, NM)

    1999-06-08T23:59:59.000Z

    A system and method for detecting the presence of dispersed broadband signals in real time. The present invention utilizes a bank of matched filters for detecting the received dispersed broadband signals. Each matched filter uses a respective robust time template that has been designed to approximate the dispersed broadband signals of interest, and each time template varies across a spectrum of possible dispersed broadband signal time templates. The received dispersed broadband signal x(t) is received by each of the matched filters, and if one or more matches occurs, then the received data is determined to have signal data of interest. This signal data can then be analyzed and/or transmitted to Earth for analysis, as desired. The system and method of the present invention will prove extremely useful in many fields, including satellite communications, plasma physics, and interstellar research. The varying time templates used in the bank of matched filters are determined as follows. The robust time domain template is assumed to take the form w(t)=A(t)cos{2.phi.(t)}. Since the instantaneous frequency f(t) is known to be equal to the derivative of the phase .phi.(t), the trajectory of a joint time-frequency representation of x(t) is used as an approximation of .phi.'(t).

  2. System and method for detection of dispersed broadband signals

    DOE Patents [OSTI]

    Qian, S.; Dunham, M.E.

    1999-06-08T23:59:59.000Z

    A system and method for detecting the presence of dispersed broadband signals in real time are disclosed. The present invention utilizes a bank of matched filters for detecting the received dispersed broadband signals. Each matched filter uses a respective robust time template that has been designed to approximate the dispersed broadband signals of interest, and each time template varies across a spectrum of possible dispersed broadband signal time templates. The received dispersed broadband signal x(t) is received by each of the matched filters, and if one or more matches occurs, then the received data is determined to have signal data of interest. This signal data can then be analyzed and/or transmitted to Earth for analysis, as desired. The system and method of the present invention will prove extremely useful in many fields, including satellite communications, plasma physics, and interstellar research. The varying time templates used in the bank of matched filters are determined as follows. The robust time domain template is assumed to take the form w(t)=A(t)cos[l brace]2[phi](t)[r brace]. Since the instantaneous frequency f(t) is known to be equal to the derivative of the phase [phi](t), the trajectory of a joint time-frequency representation of x(t) is used as an approximation of [phi][prime](t). 10 figs.

  3. Hierarchical classification of modulation signals

    E-Print Network [OSTI]

    Kim, Nam Jin

    2002-01-01T23:59:59.000Z

    This thesis addresses the problem of classifying both analog and digital modulation signals using different kinds of classifiers. The classification of modulation signals has both civilian and military applications. A total of 31 statistical signal...

  4. Metamaterials for threat reduction applications: imaging, signal processing, and cloaking

    E-Print Network [OSTI]

    Metamaterials for threat reduction applications: imaging, signal processing, and cloaking R. D effort is underway to fill this "THz gap" in view of potential threat reduction applications) and Theoretical Divisions, are exploring metamaterials-based de- vices operating at THz frequencies for threat

  5. WAVELET TRANSFORMS FOR NONLINEAR SIGNAL PROCESSING Robert Nowak

    E-Print Network [OSTI]

    domain o ers signi cant theoretical advantages over classical time or frequency domain approaches to non of higher-order statistics. Both structures are based on a two-step decom- position consisting of a linear cients. While most existing approaches to nonlinear signal processing characterize the nonlinearity

  6. Team Decision Problems with Classical and Quantum Signals

    E-Print Network [OSTI]

    Adam Brandenburger; Pierfrancesco La Mura

    2015-01-22T23:59:59.000Z

    We study team decision problems where communication is not possible, but coordination among team members can be realized via signals in a shared environment. We consider a variety of decision problems that differ in what team members know about one another's actions and knowledge. For each type of decision problem, we investigate how different assumptions on the available signals affect team performance. Specifically, we consider the cases of perfectly correlated, i.i.d., and exchangeable classical signals, as well as the case of quantum signals. We find that, whereas in perfect-recall trees (Kuhn [1950], [1953]) no type of signal improves performance, in imperfect-recall trees quantum signals may bring an improvement. Isbell [1957] proved that in non-Kuhn trees, classical i.i.d. signals may improve performance. We show that further improvement may be possible by use of classical exchangeable or quantum signals. We include an example of the effect of quantum signals in the context of high-frequency trading.

  7. Plasma Frequency Shift Due to a Slowly Rotating Compact Star

    E-Print Network [OSTI]

    Babur M. Mirza; Hamid Saleem

    2005-05-10T23:59:59.000Z

    We investigate the effects of a slowly rotating compact gravitational source on electron oscillations in a homogeneous electrically neutral plasma in the absence of an external electric or magnetic field. Neglecting the random thermal motion of the electrons we assume the gravitoelectromagnetic approximation to the general theory of relativity for the gravitational field. It is shown that there is a shift in the plasma frequency and hence in the dielectric constant of the plasma due to the gravitomagnetic force. We also give estimates for the difference in the frequency of radially transmitted electromagnetic signals for typical compact star candidates.

  8. Alpha-Stable Distributions in Signal Processing of Audio Signals

    E-Print Network [OSTI]

    Mosegaard, Klaus

    Alpha-Stable Distributions in Signal Processing of Audio Signals Preben Kidmose, Department parameter estimator for estimating the parameters in a symmetrical stable distribution. The proposed distribution, for modelling audio signals, is discussed. For a broad class of audio signals, the distribution

  9. miR-143 Interferes with ERK5 Signaling, and Abrogates Prostate Cancer Progression in Mice

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    miR-143 Interferes with ERK5 Signaling, and Abrogates Prostate Cancer Progression in Mice Cyrielle-regulated kinase-5 (ERK5) activity. We show here that ERK5 is a miR-143 target in prostate cancer. Conclusions: mi, Apparailly F, Fernandez PL, et al. (2009) miR-143 Interferes with ERK5 Signaling, and Abrogates Prostate

  10. Development/Plasticity/Repair Disrupted ERK Signaling during Cortical Development Leads

    E-Print Network [OSTI]

    Development/Plasticity/Repair Disrupted ERK Signaling during Cortical Development Leads to Abnormal disorders arising from copy number variations in the ERK (extracellular signal-regulated kinase) MAP that these changes are due to ERK-dependent dysregulation of cyclin D1 and p27Kip1 , resulting in cell cycle

  11. Epitope-Guided Engineering of Monobody Binders for in Vivo Inhibition of Erk2 Signaling

    E-Print Network [OSTI]

    Ferkey, Denise

    Epitope-Guided Engineering of Monobody Binders for in Vivo Inhibition of Erk2 Signaling Jasdeep K a defined surface patch on the mitogen activated protein kinase (MAPK) Erk-2. The targeted area ("CD" domain be useful for regulating Erk- 2 signaling in vivo. Although the CD domain constitutes only a small

  12. Mathematical Modeling of the Influence of RKIP on the ERK Signaling Pathway

    E-Print Network [OSTI]

    Rostock, Universität

    Mathematical Modeling of the Influence of RKIP on the ERK Signaling Pathway Kwang-Hyun Cho1*, Sung the influence of the Raf Kinase Inhibitor Pro- tein (RKIP) on the Extracellular signal Regulated Kinase (ERK the simulation the sensitivity of the ERK pathway to variations of initial RKIP and ERK-PP (phosphorylated ERK

  13. Decomposing Noise in Biochemical Signaling Systems Highlights the Role of Protein Degradation

    E-Print Network [OSTI]

    Miekisz, Jacek

    Decomposing Noise in Biochemical Signaling Systems Highlights the Role of Protein Degradation Micha degradation on the overall variability for a range of molecular processes and signaling systems. With our are able to show how regulated protein degradation can be employed to reduce the noise in biochem- ical

  14. Characterization of the frameshift signal of Edr, a mammalian example of programmed

    E-Print Network [OSTI]

    Bedwell, David M.

    Characterization of the frameshift signal of Edr, a mammalian example of programmed À1 ribosomal frameshifting signal of the mouse embryonal carcinoma differentiation regulated (Edr) gene represents the sole­4088]. Here, we have employed site-directed mutagenesis and RNA structure probing to characterize the Edr

  15. Compact biomedical pulsed signal generator for bone tissue stimulation

    DOE Patents [OSTI]

    Kronberg, James W. (108 Independent Blvd., Aiken, SC 29801)

    1993-01-01T23:59:59.000Z

    An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

  16. Compact biomedical pulsed signal generator for bone tissue stimulation

    DOE Patents [OSTI]

    Kronberg, J.W.

    1993-06-08T23:59:59.000Z

    An apparatus for stimulating bone tissue for stimulating bone growth or treating osteoporosis by applying directly to the skin of the patient an alternating current electrical signal comprising wave forms known to simulate the piezoelectric constituents in bone. The apparatus may, by moving a switch, stimulate bone growth or treat osteoporosis, as desired. Based on low-power CMOS technology and enclosed in a moisture-resistant case shaped to fit comfortably, two astable multivibrators produce the desired waveforms. The amplitude, pulse width and pulse frequency, and the subpulse width and subpulse frequency of the waveforms are adjustable. The apparatus, preferably powered by a standard 9-volt battery, includes signal amplitude sensors and warning signals indicate an output is being produced and the battery needs to be replaced.

  17. Coal Mining Regulations (Kentucky)

    Broader source: Energy.gov [DOE]

    Kentucky Administrative Regulation Title 405 chapters 1, 2, 3, 5, 7, 8, 10, 12, 16, 18 and 20 establish the laws governing coal mining in the state.

  18. Regulation of natural monopolies

    E-Print Network [OSTI]

    Joskow, Paul L.

    2005-01-01T23:59:59.000Z

    This chapter provides a comprehensive overview of the theoretical and empirical literature on the regulation of natural monopolies. It covers alternative definitions of natural monopoly, regulatory goals, alternative ...

  19. Regulations of Wells (Florida)

    Broader source: Energy.gov [DOE]

    The Department of Environmental Protection regulates the construction, repair, and abandonment of wells, as well as the persons and businesses undertaking such practices. Governing boards of water...

  20. Tidal Wetlands Regulations (Connecticut)

    Broader source: Energy.gov [DOE]

    Most activities occurring in or near tidal wetlands are regulated, and this section contains information on such activities and required permit applications for proposed activities. Applications...

  1. Utility Regulation (Indiana)

    Broader source: Energy.gov [DOE]

    The Indiana Utility Regulatory Commission enforces regulations in this legislation that apply to all individuals, corporations, companies, and partnerships that may own, operate, manage, or control...

  2. The Role of Docosahexaenoic Acid in Regulation of Epidermal Growth Factor Receptor Activation and Function 

    E-Print Network [OSTI]

    Turk, Harmony 1985-

    2012-08-30T23:59:59.000Z

    The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase integral in regulating cell growth, survival, and migration. EGFR signaling, which is dependent on localization of the receptor within lipid rafts, is often...

  3. Stochastic inversion in calculating the spectrum of signals with uneven sampling

    E-Print Network [OSTI]

    Ulich, Thomas

    . (2) Here sampling is considered as a measurement of the signal value and j is the true mea- surement unknonws, measurements and measurement errors into column vectors X = b1 b2 ... bm a2 a3 frequency component. When they are known, the power of the frequency component k is given by Pk = a2 k + b2

  4. 26.1 / M. Doshi 26.1: Low-Frequency Square-Wave Drive for Large Screen LCD-TV

    E-Print Network [OSTI]

    with accurate current control and regulation. The most common electronic ballasts, based on high frequency LCC and removes many of the drawbacks associated with a high frequency drive, including energy loss through26.1 / M. Doshi 26.1: Low-Frequency Square-Wave Drive for Large Screen LCD-TV Backlighting Systems

  5. Acoustic resonance frequency locked photoacoustic spectrometer

    DOE Patents [OSTI]

    Pilgrim, Jeffrey S.; Bomse, David S.; Silver, Joel A.

    2003-09-09T23:59:59.000Z

    A photoacoustic spectroscopy method and apparatus for maintaining an acoustic source frequency on a sample cell resonance frequency comprising: providing an acoustic source to the sample cell, the acoustic source having a source frequency; repeatedly and continuously sweeping the source frequency across the resonance frequency at a sweep rate; and employing an odd-harmonic of the source frequency sweep rate to maintain the source frequency sweep centered on the resonance frequency.

  6. REGULATION I: Responsibility for Creation and Amendment of Regulations

    E-Print Network [OSTI]

    REGULATION I: Responsibility for Creation and Amendment of Regulations 1. In accordance with Article 14 of the Charter, the Council shall have the power to make, amend or repeal Regulations. 2 of the Regulations and the delegation of such power pursuant to Regulation II (7.2) by the Council to Senate

  7. BT2, a BTB Scaffold Protein, Mediates Responses to Multiple Biotic and Abiotic Signals in Arabidopsis 

    E-Print Network [OSTI]

    Mandadi, Kranthi Kiran

    2011-10-21T23:59:59.000Z

    (ETO1), NON-PHOTOTROPIC HYPOCOTYL3 (NPH3), NAKED PINS IN YUC MUTANTS1 (NPY1), BLADE ON PETIOLE1 (BOP1), and NONEXPRESSER OF PR-GENES1 (NPR1) etc., have identified functional roles in ethylene signaling, blue-light signal transduction, auxin signaling... and regulate their activity. For example, the C-terminal trans-activation (TA) domain of NPR1 has two cysteine residues that act as a redox-sensor and regulates NPR1 activity to modulate expression of PATHOGENESIS RELATED (PR1) in response to salicylic acid...

  8. SECURING RADIO FREQUENCY IDENTIFICATION (RFID)

    E-Print Network [OSTI]

    business process for an organization; as a result, the security risks for RFID systems and the controls for an organization; as a result, the security risks for RFID systems and the controls available to address themMay 2007 SECURING RADIO FREQUENCY IDENTIFICATION (RFID) SYSTEMS SECURING RADIO FREQUENCY

  9. Stabilized radio-frequency quadrupole

    DOE Patents [OSTI]

    Lancaster, H.D.; Fugitt, J.A.; Howard, D.R.

    1982-09-29T23:59:59.000Z

    A long-vane stabilized radio frequency resonator for accelerating charged particles and including means defining a radio frequency resonator cavity, a plurality of long vanes mounted in the defining means for dividing the cavity into sections, and means interconnecting opposing ones of the plurality of vanes for stabilizing the resonator.

  10. Workshop in Regulation &

    E-Print Network [OSTI]

    Lin, Xiaodong

    Smart Grid and Regulatory Issues April 1, 2011 K&L Gates LLP, 1601 K Street, NW, Washington, DC Viable Regulation." Victor Glass, NECA, Comments January 14, 2011 Smart Grid and Regulatory Issues Location: Rutgers, The Brattle Group, "Smart Grid/Smart Regulation" John Caldwell, EEI, "Economic Efficiency and the Smart Grid

  11. Bacterial signaling and motility: Sure bets

    SciTech Connect (OSTI)

    Zhulin, Igor B [University of Tennessee, Knoxville (UTK) & Oak Ridge National Laboratory (ORNL)

    2008-01-01T23:59:59.000Z

    The IX International Conference on Bacterial Locomotion and Signal Transduction (BLAST IX) was held from 14 to 19 January 2007 in Laughlin, NV, a town in the Mojave Desert on the Nevada-Arizona border near old Route 66 and along the banks of the Colorado River. This area is a home to rattlesnakes, sagebrush, abandoned gold mines, and compulsive gamblers. What better venue could scientists possibly dream of for a professional meeting? So there they were, about 190 scientists gathered in the Aquarius Casino Resort, the largest hotel and casino in Laughlin, discussing the latest advances in the field. Aside from a brief excursion to an abandoned gold mine and a dinner cruise on the Colorado River, the scientists focused on nothing but their data and hypotheses, in spirited arguments and rebuttals, and outlined their visions and future plans in a friendly and open environment. The BLAST IX program was dense, with nearly 50 talks and over 90 posters. For that reason, this meeting report will not attempt to be comprehensive; instead it will first provide general background information on the central topics of the meeting and then highlight only a few talks that were of special interest to us and hopefully to the wider scientific community. We will also attempt to articulate some of the future directions or perspectives to the best of our abilities. The best known and understood bacterial motility mechanism is swimming powered by flagella. The rotation of bacterial flagella drives this form of bacterial movement in an aqueous environment. A bacterial flagellum consists of a helical filament attached to the cell body through a complex structure known as the hook-basal body, which drives flagellar rotation. The essential components of the basal body are the MotA-MotB motor-stator proteins bound to the cytoplasmic membrane. These stator proteins interact with proteins that comprise the supramembrane and cytoplasmic rings, which are components of the motor imbedded in the cytoplasmic membrane. The interaction causes the supramembrane and cytoplasmic rings to rotate along with the flagellar filaments. The energy for flagellar rotation comes from proton motive force or other ions, especially sodium in marine bacteria, which generate an electrochemical gradient across the cell membrane. Three proteins, FliM, FliN, and FliG, located at the base of the motor act as switches that control the direction of flagellar rotation. As exemplified by the enteric bacteria Escherichia coli and Salmonella enterica serovar Typhimurium, changes in the direction of flagellar rotation affect the swimming behavior of the bacterial cell. Counterclockwise (CCW) rotation of the flagella causes the flagellar filaments to form a bundle that pushes the cell forward in a 'run.' In contrast, clockwise (CW) rotation causes the flagellar bundle to fly apart, and the cell tumbles to reorient to a new direction for the ensuing run upon the return of CCW rotation. The interchanging pattern of CCW and CW rotations produces a random walk, composed of relatively long runs with occasional direction changes or turns. By modulating the lengths of the runs or the frequency of tumbling, bacteria can regulate their motile behavior to move in a desirable direction. Many bacteria can also move on surfaces. Except for flagellum-driven swarming motility, all the other forms of known bacterial surface movement involve no flagella. The flagellum-independent surface motility, known as gliding, is observed in cyanobacteria, Mycoplasma species, Cytophaga-Flexibacterium species, and Myxococcus species. Without a doubt, the most thoroughly studied model gliding bacterium is Myxococcus xanthus, which also serves as a prokaryotic model for developmental biology due to its ability to develop multicellular fruiting bodies. M. xanthus cells use gliding motility both to hunt for food during vegetative growth and to aggregate during fruiting body formation. When nutrients are present, groups of cells or swarms propagate and move outward like hunting wolf packs in search of additional macromole

  12. Planck Early Results: The Low Frequency Instrument data processing

    E-Print Network [OSTI]

    Zacchei, A; Baccigalupi, C; Bersanelli, M; Bonaldi, A; Bonavera, L; Burigana, C; Butler, R C; Cuttaia, F; de Zotti, G; Dick, J; Frailis, M; Galeotta, S; González-Nuevo, J; Górski, K M; Gregorio, A; Keihänen, E; Keskitalo, R; Knoche, J; Kurki-Suonio, H; Lawrence, C R; Leach, S; Leahy, J P; López-Caniego, M; Mandolesi, N; Maris, M; Matthai, F; Meinhold, P R; Mennella, A; Morgante, G; Morisset, N; Natoli, P; Pasian, F; Perrotta, F; Polenta, G; Poutanen, T; Reinecke, M; Ricciardi, S; Rohlfs, R; Sandri, M; Suur-Uski, A -S; Tauber, J A; Tavagnacco, D; Terenzi, L; Tomasi, M; Valiviita, J; Villa, F; Zonca, A; Banday, A J; Barreiro, R B; Bartlett, J G; Bartolo, N; Bedini, L; Bennett, K; Binko, P; Borrill, J; Bouchet, F R; Bremer, M; Cabella, P; Cappellini, B; Chen, X; Colombo, L; Cruz, M; Curto, A; Danese, L; Davies, R D; Davis, R J; de Gasperis, G; de Rosa, A; de Troia, G; Dickinson, C; Diego, J M; Donzelli, S; Dörl, U; Efstathiou, G; En\\sslin, T A; Eriksen, H K; Falvella, M C; Finelli, F; Franceschi, E; Gaier, T C; Gasparo, F; Génova-Santos, R T; Giardino, G; Gómez, F; Gruppuso, A; Hansen, F K; Hell, R; Herranz, D; Hovest, W; Jewell, J; Juvela, M; Kisner, T S; Knox, L; Lähteenmäki, A; Lamarre, J -M; Leonardi, R; León-Tavares, J; Lilje, P B; Lubin, P M; Maggio, G; Marinucci, D; Martínez-González, E; Massardi, M; Matarrese, S; Meharga, M T; Melchiorri, A; Migliaccio, M; Mitra, S; Moss, A; N\\orgaard-Nielsen, H U; Pagano, L; Paladini, R; Paoletti, D; Partridge, B; Pearson, D; Pettorino, V; Pietrobon, D; Prézeau, G; Procopio, P; Puget, J -L; Quercellini, C; Rachen, J P; Rebolo, R; Robbers, G; Rocha, G; Rubi\; Salerno, E; Savelainen, M; Scott, D; Seiffert, M D; Silk, J I; Smoot, G F; Sternberg, J; Stivoli, F; Stompor, R; Tofani, G; Tuovinen, J; Türler, M; Umana, G; Vielva, P; Vittorio, N; Vuerli, C; Wade, L A; Watson, R; White, S D M; Wilkinson, A

    2011-01-01T23:59:59.000Z

    We describe the data processing pipeline employed by the Low Frequency Instrument (LFI) Data Processing Centre (DPC) to create and characterize the frequency maps used by the ERCSC (Early Release Compact Source Catalogue) first product of Planck to become public. In particular, we discuss the various steps involved in reducing the data, starting from telemetry (TM)packets through to the production of cleaned calibrated timelines and calibrated frequency maps. Data are continuously calibrated using the modulation induced on the mean temperature of the Cosmic Microwave Background Radiation by the proper motion of the spacecraft. The sky signals other than the dipole are removed by an iterative procedure based on simultaneous fitting of calibration parameters and sky maps. Noise properties are estimated from time-ordered data where the sky signal is removed using a Generalized Least Square map-making algorithm. The measured 1/f noise knee-frequencies range from \\sim 100 mHz at 30 GHz to a few tens of mHz at 70 G...

  13. Hydraulic impulse generator and frequency sweep mechanism for borehole applications

    DOE Patents [OSTI]

    Kolle, Jack J.; Marvin, Mark H.; Theimer, Kenneth J.

    2006-11-21T23:59:59.000Z

    This invention discloses a valve that generates a hydraulic negative pressure pulse and a frequency modulator for the creation of a powerful, broadband swept impulse seismic signal at the drill bit during drilling operations. The signal can be received at monitoring points on the surface or underground locations using geophones. The time required for the seismic signal to travel from the source to the receiver directly and via reflections is used to calculate seismic velocity and other formation properties near the source and between the source and receiver. This information can be used for vertical seismic profiling of formations drilled, to check the location of the bit, or to detect the presence of abnormal pore pressure ahead of the bit. The hydraulic negative pressure pulse can also be used to enhance drilling and production of wells.

  14. Experimental study of frequency multipliers based on a GaAs/AlAs semiconductor superlattices in the terahertz frequency range

    SciTech Connect (OSTI)

    Paveliev, D. G., E-mail: pavelev@rf.unn.ru; Koshurinov, Y. I.; Ivanov, A. S. [Lobachevskii State University of Nizhny Novgorod (Russian Federation); Panin, A. N.; Vax, V. L.; Gavrilenko, V. I.; Antonov, A. V. [Russian Academy of Sciences, Institute for Physics of Microstructures (Russian Federation); Ustinov, V. M. [Russian Academy of Sciences, Ioffe Physical Technical Institute (Russian Federation); Zhukov, A. E. [Russian Academy of Sciences, St. Petersburg Academic University-Nanotechnology Research and Education Center (Russian Federation)

    2012-01-15T23:59:59.000Z

    Frequency multipliers based on a GaAs/AlAs semiconductor quantum superlattice have been experimentally studied. The power spectrum of the harmonics in the output signal from a multiplier with an input-signal frequency of 140-160 GHz has been measured. Planar diodes with a small active region (an area of 1-2 {mu}m{sup 2}) have been used in this study. For fabrication of the diodes, structures of heavily doped superlattices with the miniband width 24 meV have been used, these structures were grown by the molecular-beam epitaxy method. Measurements have been conducted using a BOMEM DA3.36 Fourier spectrometer equipped with a detector based on a bolometer cooled to the temperature of liquid helium. The results of the measurements have been used to plot the dependences of the power of the harmonics on the frequency in the range from 0.4 to 8.1 THz. It has been found that the character of the microwave-power distribution over the number of harmonics is close to the spectrum of a sequence of sign-alternating pulses which appear in the diode circuit when the applied voltage of the input signal exceeds the threshold of the diode. The minimal time of establishment of the pulse front and pulse duration are equal to 123 and 667 fs, respectively.

  15. Post-translational regulation enables robust p53 regulation

    E-Print Network [OSTI]

    Shin, Yong-Jun; Chen, Kai-Yuan; Sayed, Ali H; Hencey, Brandon; Shen, Xiling

    2013-01-01T23:59:59.000Z

    PS, Elowitz MB: Gene regulation at the single-cell level.JC, Song B, Kudo K, Chu E: Regulation of p53 expression inChen L, Li Z, et al: Regulation of MDM2 E3 ligase activity

  16. Development/Plasticity/Repair The ERK2 Mitogen-Activated Protein Kinase Regulates the

    E-Print Network [OSTI]

    Development/Plasticity/Repair The ERK2 Mitogen-Activated Protein Kinase Regulates the Timing Oligodendrocytedevelopmentistightlycontrolledbyavarietyofextracellulargrowthanddifferentiationfactors.Themitogen-activated protein kinases (MAPKs), ERK1 and ERK2, are critical intracellular signaling (ERKs) are ubiquitously expressed, coordinately regulated, and highly similar, but Erk2 deletion in mice

  17. Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4

    E-Print Network [OSTI]

    Dinner, Aaron

    analyses have led to the formulation of a ``kinetic control'' model for the regulation of B cell-f results support a model of ``kinetic control'' in which signaling-induced dynamics of IRF4 in activated BImmunity Article Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical

  18. Tailpulse signal generator

    DOE Patents [OSTI]

    Baker, John (Walnut Creek, CA); Archer, Daniel E. (Knoxville, TN); Luke, Stanley John (Pleasanton, CA); Decman, Daniel J. (Livermore, CA); White, Gregory K. (Livermore, CA)

    2009-06-23T23:59:59.000Z

    A tailpulse signal generating/simulating apparatus, system, and method designed to produce electronic pulses which simulate tailpulses produced by a gamma radiation detector, including the pileup effect caused by the characteristic exponential decay of the detector pulses, and the random Poisson distribution pulse timing for radioactive materials. A digital signal process (DSP) is programmed and configured to produce digital values corresponding to pseudo-randomly selected pulse amplitudes and pseudo-randomly selected Poisson timing intervals of the tailpulses. Pulse amplitude values are exponentially decayed while outputting the digital value to a digital to analog converter (DAC). And pulse amplitudes of new pulses are added to decaying pulses to simulate the pileup effect for enhanced realism in the simulation.

  19. Power Supply Rejection Improvement Techniques In Low Drop-Out Voltage Regulators

    E-Print Network [OSTI]

    Ganta, Saikrishna

    2011-10-21T23:59:59.000Z

    , the conventional LDOs have poor PSR at high frequencies. The objective of this research is to develop novel LDO regulators that can achieve good high frequency PSR performance. In this thesis, two PSR improvement methods are presented. The first method proposes a...

  20. Army Regulation 690600 Civilian Personnel

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Army Regulation 690­600 Civilian Personnel Equal Employment Opportunity Discrimination Complaints Civilian Personnel Equal Employment Opportunity Discrimination Complaints *Army Regulation 690­600 Effective 9 March 2004 History. This publication is a major revision. Summary. This regulation establishes

  1. California Energy Commission PROPOSED REGULATIONS

    E-Print Network [OSTI]

    California Energy Commission PROPOSED REGULATIONS ENFORCEMENT PROCEDURES on concepts for the proposed regulations. Energy Commission staff held additional public workshops on March regulations. Throughout this process, the Energy Commission received and considered comments from

  2. California Energy Commission PROPOSED REGULATIONS

    E-Print Network [OSTI]

    California Energy Commission PROPOSED REGULATIONS MARCH 2012 CEC-400-2010-004-SD3 NONRESIDENTIAL BUILDING ENERGY USE DISCLOSURE PROGRAM Proposed Regulations Title 20, Division 2, Chapter 4 PREFACE The California Energy Commission is releasing proposed regulations for implementing Assembly

  3. Regulation of Xylella fastidiosa virulence factors by c-di-GMP phosphodiesterases 

    E-Print Network [OSTI]

    Ancona-Contreras, Veronica

    2012-10-19T23:59:59.000Z

    polysaccharides and the formation of a biofilm. These traits are mediated in a cell-density manner by a cell-to-cell signaling system that transduces a diffusible signaling factor (DSF). This dissertation demonstrates that PD1994, PD1617 and RpfG regulate...

  4. Radar transponder apparatus and signal processing technique

    DOE Patents [OSTI]

    Axline, Jr., Robert M. (Albuquerque, NM); Sloan, George R. (Albuquerque, NM); Spalding, Richard E. (Albuquerque, NM)

    1996-01-01T23:59:59.000Z

    An active, phase-coded, time-grating transponder and a synthetic-aperture radar (SAR) and signal processor means, in combination, allow the recognition and location of the transponder (tag) in the SAR image and allow communication of information messages from the transponder to the SAR. The SAR is an illuminating radar having special processing modifications in an image-formation processor to receive an echo from a remote transponder, after the transponder receives and retransmits the SAR illuminations, and to enhance the transponder's echo relative to surrounding ground clutter by recognizing special transponder modulations from phase-shifted from the transponder retransmissions. The remote radio-frequency tag also transmits information to the SAR through a single antenna that also serves to receive the SAR illuminations. Unique tag-modulation and SAR signal processing techniques, in combination, allow the detection and precise geographical location of the tag through the reduction of interfering signals from ground clutter, and allow communication of environmental and status information from said tag to be communicated to said SAR.

  5. Diffusion, dimensionality and noise in transcriptional regulation

    E-Print Network [OSTI]

    Gasper Tkacik; William Bialek

    2007-12-12T23:59:59.000Z

    The precision of biochemical signaling is limited by randomness in the diffusive arrival of molecules at their targets. For proteins binding to the specific sites on the DNA and regulating transcription, the ability of the proteins to diffuse in one dimension by sliding along the length of the DNA, in addition to their diffusion in bulk solution, would seem to generate a larger target for DNA binding, consequently reducing the noise in the occupancy of the regulatory site. Here we show that this effect is largely cancelled by the enhanced temporal correlations in one dimensional diffusion. With realistic parameters, sliding along DNA has surprisingly little effect on the physical limits to the precision of transcriptional regulation.

  6. Frequency Scalable Non-Linear Waveform Generator for Mixed-Simal Power-Factor-Correction IC Controller'

    E-Print Network [OSTI]

    -frequency applications due to the complex, real-time computations demanded of the controller. This paper introduces a non-linear-Signal IC Gontroller Block Diagram frequency scalable non-linear waveform generators for the IC controller techniques [5]. The controller is based on the non-linear carrier (NLC) control method [6]. At the beginning

  7. June 15, 1998 / Vol. 23, No. 12 / OPTICS LETTERS 975 Frequency-swept ultrasound-modulated optical

    E-Print Network [OSTI]

    Wang, Lihong

    and amplitude by a power amplifier and a transformer, respectively. The instantaneous frequency of the fre to image objects buried inside the scattering media. A one- dimensional (1D) image along the ultrasonic in Fig. 1. A function generator produced a frequency- swept signal, which then was amplified in power

  8. Microwave and Radio Frequency Workshop

    Broader source: Energy.gov [DOE]

    At the Microwave and Radio Frequency Workshop (held in Long Beach, CA, on July 25, 2012), academic and industry experts discussed the existing and emerging electrotechnologies – such as microwave ...

  9. Frequency-domain criterion for the speech distortion weighted multichannel Wiener filter for robust noise reduction q

    E-Print Network [OSTI]

    systems. Therefore efficient speech enhancement techniques are called for. Since the desired speech signal and the undesired noise signal usually occupy overlapping frequency bands, sin- gle-microphone speech enhancement and the spatial characteristics of the sources can be used. Well-known multi-microphone speech enhancement

  10. Methods and systems for low frequency seismic and infrasound detection of geo-pressure transition zones

    DOE Patents [OSTI]

    Shook, G. Michael; LeRoy, Samuel D.; Benzing, William M.

    2006-07-18T23:59:59.000Z

    Methods for determining the existence and characteristics of a gradational pressurized zone within a subterranean formation are disclosed. One embodiment involves employing an attenuation relationship between a seismic response signal and increasing wavelet wavelength, which relationship may be used to detect a gradational pressurized zone and/or determine characteristics thereof. In another embodiment, a method for analyzing data contained within a response signal for signal characteristics that may change in relation to the distance between an input signal source and the gradational pressurized zone is disclosed. In a further embodiment, the relationship between response signal wavelet frequency and comparative amplitude may be used to estimate an optimal wavelet wavelength or range of wavelengths used for data processing or input signal selection. Systems for seismic exploration and data analysis for practicing the above-mentioned method embodiments are also disclosed.

  11. Systems for low frequency seismic and infrasound detection of geo-pressure transition zones

    DOE Patents [OSTI]

    Shook, G. Michael (Idaho Falls, ID); LeRoy, Samuel D. (Houston, TX); Benzing, William M. (Tulsa, OK)

    2007-10-16T23:59:59.000Z

    Methods for determining the existence and characteristics of a gradational pressurized zone within a subterranean formation are disclosed. One embodiment involves employing an attenuation relationship between a seismic response signal and increasing wavelet wavelength, which relationship may be used to detect a gradational pressurized zone and/or determine characteristics thereof. In another embodiment, a method for analyzing data contained within a response signal for signal characteristics that may change in relation to the distance between an input signal source and the gradational pressurized zone is disclosed. In a further embodiment, the relationship between response signal wavelet frequency and comparative amplitude may be used to estimate an optimal wavelet wavelength or range of wavelengths used for data processing or input signal selection. Systems for seismic exploration and data analysis for practicing the above-mentioned method embodiments are also disclosed.

  12. SIGNAL PROCESSING FOR SEMICONDUCTOR DETECTORS

    E-Print Network [OSTI]

    Colliding, F.S.

    2010-01-01T23:59:59.000Z

    is the same as the step response of the shaper. The shaperthe figure shows the step response (and therefore the signal15, by sliding the step response past the signal peasure-

  13. Dam Safety Regulation (Mississippi)

    Broader source: Energy.gov [DOE]

    The purpose of the Dam Safety Regulation is to ensure that all dams constructed in the state of Mississippi are permitted and thus do not potentially harm wildlife, water supplies and property. ...

  14. Dam Safety Regulations (Connecticut)

    Broader source: Energy.gov [DOE]

    All dams, except those owned by the U.S., are under the jurisdiction of these regulations. These dams will be classified by hazard rating, and may be subject to periodic inspections. The...

  15. Of Refrigerators & Regulations

    Broader source: Energy.gov [DOE]

    Editor's Note: This entry has been cross-posted from The White House Blog. The President took a moment during his speech to put the debate over regulation in a different perspective.

  16. Sulfur Dioxide Regulations (Ohio)

    Broader source: Energy.gov [DOE]

    This chapter of the law establishes that the Ohio Environmental Protection Agency provides sulfur dioxide emission limits for every county, as well as regulations for the emission, monitoring and...

  17. Underground Storage Tank Regulations

    Broader source: Energy.gov [DOE]

    The Underground Storage Tank Regulations is relevant to all energy projects that will require the use and building of pipelines, underground storage of any sorts, and/or electrical equipment. The...

  18. Regulation 2: Student Discipline REGULATION 2: STUDENT DISCIPLINE

    E-Print Network [OSTI]

    Sussex, University of

    Regulation 2: Student Discipline 6 REGULATION 2: STUDENT DISCIPLINE 1. Definitions In this Regulation: The University means the University of Sussex. Council means Council of the University. Senate to the regulations of the affiliated institution, and excluding students in attendance at the Brighton and Sussex

  19. SB 4 Well Stimulation Treatment Regulations Text of Proposed Regulations

    E-Print Network [OSTI]

    surveys; routine activities that do not affect the integrity of the well or the formation; the removal SB 4 Well Stimulation Treatment Regulations Text of Proposed Regulations Page 1 of 13 SB 4 WELL STIMULATION TREATMENT REGULATIONS TEXT OF PROPOSED REGULATIONS Added text is shown in underline

  20. Rapid prototyping for radio-frequency geolocation applications

    SciTech Connect (OSTI)

    Briles, S. C. (Scott C.); Arrowood, J. L. (Joseph L.); Braun, T. R. (Thomas R.); Turcotte, D. (Dakx); Fiset, E. (Etienne)

    2004-01-01T23:59:59.000Z

    Previous space-to-ground, single-platform geolocation experiments exploiting time-difference-of arrival (TDOA) via interferometry were successful at separating and quantitatively characterizing interfering radio frequency (RF) signals from expected RF transmissions. Much of the success of these experiments rested on the use of embedded processors to perform the required signal processing. The experiments handled data in a 'snapshot' fashion: digitized data was collected, the data was processed via a digital signal processing (DSP) microprocessor to yield differential phase measurements, and these measurements were transmitted to the Earth for geolocation processing. With the utilization of FPGAs (field programmable gate arrays) for the intensive number-crunching algorithms, the processing of streaming real-time data is feasible for bandwidths on the order of 20 MHz. By partitioning the signal processing algorithm so there is a significant reduction in the data rate as data flows through the FPGA, a DSP microprocessor can now be employed to perform further decision-oriented processing on the FPGA output. This hybrid architecture, employing both FPGAs and DSPs, typically requires an expensive and lengthy development cycle. However, the use of graphical development environments with auto-code generation and hardware-in-the-loop testing can result in rapid prototyping for geolocation experiments, which enables adaptation to emerging signals of interest in a cost and time effective manner.

  1. Method and apparatus for powering an electrodeless lamp with reduced radio frequency interference

    DOE Patents [OSTI]

    Simpson, James E. (Gaithersburg, MD)

    1999-01-01T23:59:59.000Z

    An electrodeless lamp waveguide structure includes tuned absorbers for spurious RF signals. A lamp waveguide with an integral frequency selective attenuation includes resonant absorbers positioned within the waveguide to absorb spurious out-of-band RF energy. The absorbers have a negligible effect on energy at the selected frequency used to excite plasma in the lamp. In a first embodiment, one or more thin slabs of lossy magnetic material are affixed to the sidewalls of the waveguide at approximately one quarter wavelength of the spurious signal from an end wall of the waveguide. The positioning of the lossy material optimizes absorption of power from the spurious signal. In a second embodiment, one or more thin slabs of lossy magnetic material are used in conjunction with band rejection waveguide filter elements. In a third embodiment, one or more microstrip filter elements are tuned to the frequency of the spurious signal and positioned within the waveguide to couple and absorb the spurious signal's energy. All three embodiments absorb negligible energy at the selected frequency and so do not significantly diminish the energy efficiency of the lamp.

  2. Method and apparatus for powering an electrodeless lamp with reduced radio frequency interference

    DOE Patents [OSTI]

    Simpson, J.E.

    1999-06-08T23:59:59.000Z

    An electrodeless lamp waveguide structure includes tuned absorbers for spurious RF signals. A lamp waveguide with an integral frequency selective attenuation includes resonant absorbers positioned within the waveguide to absorb spurious out-of-band RF energy. The absorbers have a negligible effect on energy at the selected frequency used to excite plasma in the lamp. In a first embodiment, one or more thin slabs of lossy magnetic material are affixed to the sidewalls of the waveguide at approximately one quarter wavelength of the spurious signal from an end wall of the waveguide. The positioning of the lossy material optimizes absorption of power from the spurious signal. In a second embodiment, one or more thin slabs of lossy magnetic material are used in conjunction with band rejection waveguide filter elements. In a third embodiment, one or more microstrip filter elements are tuned to the frequency of the spurious signal and positioned within the waveguide to couple and absorb the spurious signal's energy. All three embodiments absorb negligible energy at the selected frequency and so do not significantly diminish the energy efficiency of the lamp. 18 figs.

  3. Design of Analog & Mixed Signal Circuits in Continuous-Time Sigma-Delta Modulators for System-on-Chip applications

    E-Print Network [OSTI]

    Park, Chang Joon

    2013-08-22T23:59:59.000Z

    Software-defined radio receivers (SDRs) have become popular to accommodate multi-standard wireless services using a single chip-set solution in mobile telecommunication systems. In SDRs, the signal is down-converted to an intermediate frequency...

  4. System and method for investigating sub-surface features of a rock formation with acoustic sources generating coded signals

    DOE Patents [OSTI]

    Vu, Cung Khac; Nihei, Kurt; Johnson, Paul A; Guyer, Robert; Ten Cate, James A; Le Bas, Pierre-Yves; Larmat, Carene S

    2014-12-30T23:59:59.000Z

    A system and a method for investigating rock formations includes generating, by a first acoustic source, a first acoustic signal comprising a first plurality of pulses, each pulse including a first modulated signal at a central frequency; and generating, by a second acoustic source, a second acoustic signal comprising a second plurality of pulses. A receiver arranged within the borehole receives a detected signal including a signal being generated by a non-linear mixing process from the first-and-second acoustic signal in a non-linear mixing zone within the intersection volume. The method also includes-processing the received signal to extract the signal generated by the non-linear mixing process over noise or over signals generated by a linear interaction process, or both.

  5. Price regulation for waste hauling franchises in California: an examination of how regulators regulate pricing and the effects of competition on regulated markets

    E-Print Network [OSTI]

    Seltzer, Steven A.

    2011-01-01T23:59:59.000Z

    and popular recent “incentive regulation” alternatives,if costs increase. Incentive regulation – most particularly

  6. High frequency and high wavenumber solar oscillations

    E-Print Network [OSTI]

    H. M. Antia; Sarbani Basu

    1999-02-10T23:59:59.000Z

    We determine the frequencies of solar oscillations covering a wide range of degree (100< l <4000) and frequency (1.5 <\

  7. Sum Frequency Generation for Surface Vibrational Spectroscopy...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Sum Frequency Generation for Surface Vibrational Spectroscopy Sum Frequency Generation for Surface Vibrational Spectroscopy This customized SFG-VS spectrometer incorporates unique...

  8. Rap G protein signal in normal and disordered lymphohematopoiesis

    SciTech Connect (OSTI)

    Minato, Nagahiro, E-mail: minato@imm.med.kyoto-u.ac.jp

    2013-09-10T23:59:59.000Z

    Rap proteins (Rap1, Rap2a, b, c) are small molecular weight GTPases of the Ras family. Rap G proteins mediate diverse cellular events such as cell adhesion, proliferation, and gene activation through various signaling pathways. Activation of Rap signal is regulated tightly by several specific regulatory proteins including guanine nucleotide exchange factors and GTPase-activating proteins. Beyond cell biological studies, increasing attempts have been made in the past decade to define the roles of Rap signal in specific functions of normal tissue systems as well as in cancer. In the immune and hematopoietic systems, Rap signal plays crucial roles in the development and function of essentially all lineages of lymphocytes and hematopoietic cells, and importantly, deregulated Rap signal may lead to unique pathological conditions depending on the affected cell types, including various types of leukemia and autoimmunity. The phenotypical studies have unveiled novel, even unexpected functional aspects of Rap signal in cells from a variety of tissues, providing potentially important clues for controlling human diseases, including malignancy.

  9. First event signalling correlations

    E-Print Network [OSTI]

    Debashis Saha; Marcin Paw?owski

    2015-04-20T23:59:59.000Z

    This work introduces the notion of First Event Signalling (FES) correlations in multipartite scenario where the first measurement on one subsystem influences the measurement outcomes of all the other local subsystems. It is shown that these correlations are related to bilocal ones but stronger than their variations proposed earlier. We propose a new Bell inequality which is satisfied by all FES models. Then we show quantum mechanical violation of this inequality, which can be regarded as an alternative definition of a stronger type of genuine multipartite nonlocality and a proof that quantum mechanics exhibits even more powerful correlations than these already known. We also introduce another Bell inequality which is satisfied by all bilocal correlations but violated by FES. The study of our new inequalities and the ones introduced previously allows us to analyze the relation between different types of tripartite nonlocality which reveals a very complex and interesting structure.

  10. Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3

    E-Print Network [OSTI]

    Carlson, Scott M.

    The mitogen-activated protein kinase (MAPK) extracellular signal–regulated kinase 2 (ERK2) is ubiquitously expressed in mammalian tissues and is involved in a wide range of biological processes. Although MAPKs have been ...

  11. Plug-and-play voltage and frequency control of islanded microgrids with meshed topology

    E-Print Network [OSTI]

    Ferrari-Trecate, Giancarlo

    generation since, differently from common diesel generators, power is produced and delivered to the main grid Generation Units (DGUs). Local controllers regulate voltage and frequency at the Point of Common Coupling Distributed Generation Units (DGUs) designed to operate safely and reliably in absence of a connection

  12. Frequency agile optical parametric oscillator

    DOE Patents [OSTI]

    Velsko, Stephan P. (Livermore, CA)

    1998-01-01T23:59:59.000Z

    The frequency agile OPO device converts a fixed wavelength pump laser beam to arbitrary wavelengths within a specified range with pulse to pulse agility, at a rate limited only by the repetition rate of the pump laser. Uses of this invention include Laser radar, LIDAR, active remote sensing of effluents/pollutants, environmental monitoring, antisensor lasers, and spectroscopy.

  13. Frequency agile optical parametric oscillator

    DOE Patents [OSTI]

    Velsko, S.P.

    1998-11-24T23:59:59.000Z

    The frequency agile OPO device converts a fixed wavelength pump laser beam to arbitrary wavelengths within a specified range with pulse to pulse agility, at a rate limited only by the repetition rate of the pump laser. Uses of this invention include Laser radar, LIDAR, active remote sensing of effluents/pollutants, environmental monitoring, antisensor lasers, and spectroscopy. 14 figs.

  14. Analyzing gigahertz bunch length instabilities with a digital signal processor

    SciTech Connect (OSTI)

    Stege, R.E. Jr.; Krejcik, P.; Minty, M.G.

    1992-11-01T23:59:59.000Z

    A bunch length instability, nicknamed the ``sawtooth``, because of its transient behavior, has been observed at high current running in the Stanford Linear Collider (SLC) electron damping ring. The incompatibility of this instability with successful SLC naming prompted its study using a high bandwidth real-time spectrum analyzer, the Tektronix 3052 digital signal processor (DSP) system. This device has been used to study energy ramping in storage rings but this is the first time it has been used to study transient instability phenomena. It is a particularly valuable tool for use in understanding non-linear, multiple frequency phenomena. The frequency range of this device has been extended through the use of radio frequency (RF) down converters. This paper describes the measurement setup and presents some of the results.

  15. Analyzing gigahertz bunch length instabilities with a digital signal processor

    SciTech Connect (OSTI)

    Stege, R.E. Jr.; Krejcik, P.; Minty, M.G.

    1992-11-01T23:59:59.000Z

    A bunch length instability, nicknamed the sawtooth'', because of its transient behavior, has been observed at high current running in the Stanford Linear Collider (SLC) electron damping ring. The incompatibility of this instability with successful SLC naming prompted its study using a high bandwidth real-time spectrum analyzer, the Tektronix 3052 digital signal processor (DSP) system. This device has been used to study energy ramping in storage rings but this is the first time it has been used to study transient instability phenomena. It is a particularly valuable tool for use in understanding non-linear, multiple frequency phenomena. The frequency range of this device has been extended through the use of radio frequency (RF) down converters. This paper describes the measurement setup and presents some of the results.

  16. LOW-FREQUENCY OBSERVATIONS OF THE MOON WITH THE MURCHISON WIDEFIELD ARRAY

    SciTech Connect (OSTI)

    McKinley, B.; Briggs, F. [Research School of Astronomy and Astrophysics, Australian National University, Canberra (Australia); Kaplan, D. L. [Department of Physics, University of Wisconsin-Milwaukee, Milwaukee, WI (United States); Greenhill, L. J.; Bernardi, G.; De Oliveira-Costa, A. [Harvard-Smithsonian Center for Astrophysics, Cambridge, MA (United States); Bowman, J. D. [School of Earth and Space Exploration, Arizona State University, Tempe, AZ (United States); Tingay, S. J.; Gaensler, B. M. [ARC Centre of Excellence for All-Sky Astrophysics (CAASTRO), School of Physics, The University of Sydney, Sydney, NSW (Australia); Oberoi, D. [National Centre for Radio Astrophysics, Tata Institute for Fundamental Research, Pune (India); Johnston-Hollitt, M. [School of Chemical and Physical Sciences, Victoria University of Wellington, Wellington (New Zealand); Arcus, W.; Emrich, D. [International Centre for Radio Astronomy Research, Curtin University, Perth (Australia); Barnes, D. [Center for Astrophysics and Supercomputing, Swinburne University of Technology, Melbourne (Australia); Bunton, J. D. [CSIRO Astronomy and Space Science, Canberra (Australia); Cappallo, R. J.; Corey, B. E. [MIT Haystack Observatory, Westford, MA (United States); Deshpande, A. [Raman Research Institute, Bangalore (India); DeSouza, L. [Sydney Institute for Astronomy, School of Physics, University of Sydney, Sydney (Australia); Goeke, R. [MIT Kavli Institute for Astrophysics and Space Research, Cambridge, MA (United States); and others

    2013-01-01T23:59:59.000Z

    A new generation of low-frequency radio telescopes is seeking to observe the redshifted 21 cm signal from the epoch of reionization (EoR), requiring innovative methods of calibration and imaging to overcome the difficulties of wide-field low-frequency radio interferometry. Precise calibration will be required to separate the expected small EoR signal from the strong foreground emission at the frequencies of interest between 80 and 300 MHz. The Moon may be useful as a calibration source for detection of the EoR signature, as it should have a smooth and predictable thermal spectrum across the frequency band of interest. Initial observations of the Moon with the Murchison Widefield Array 32 tile prototype show that the Moon does exhibit a similar trend to that expected for a cool thermally emitting body in the observed frequency range, but that the spectrum is corrupted by reflected radio emission from Earth. In particular, there is an abrupt increase in the observed flux density of the Moon within the internationally recognized frequency modulated (FM) radio band. The observations have implications for future low-frequency surveys and EoR detection experiments that will need to take this reflected emission from the Moon into account. The results also allow us to estimate the equivalent isotropic power emitted by the Earth in the FM band and to determine how bright the Earth might appear at meter wavelengths to an observer beyond our own solar system.

  17. Semi-classical signal analysis

    E-Print Network [OSTI]

    Taous-Meriem Laleg-Kirati; Emmanuelle Crépeau; Michel Sorine

    2010-07-06T23:59:59.000Z

    This study introduces a new signal analysis method called SCSA, based on a semi-classical approach. The main idea in the SCSA is to interpret a pulse-shaped signal as a potential of a Schr\\"odinger operator and then to use the discrete spectrum of this operator for the analysis of the signal. We present some numerical examples and the first results obtained with this method on the analysis of arterial blood pressure waveforms.

  18. Workshop in Regulation &

    E-Print Network [OSTI]

    Lin, Xiaodong

    Consulting "Pipeline - A Reincarnation of Stranded Costs" Sean K. Collins, Federal Energy Regulatory Industries November 16, 2012 Rutgers Business School, 1 Washington Park Newark, NJ Regulation, Smart Grid and Reliability January 11, 2013 Rutgers Business School, 1 Washington Park Newark, NJ Generation and Demand

  19. Design of Optimal Regulators

    E-Print Network [OSTI]

    Alexander Bolonkin; Robert Sierakowski

    2007-01-19T23:59:59.000Z

    Current research suggests the use of a liner quadratic performance index for optimal control of regulators in various applications. Some examples include correcting the trajectory of rocket and air vehicles, vibration suppression of flexible structures, and airplane stability. In all these cases, the focus is in suppressing/decreasing system deviations rapidly. However, if one compares the Linear Quadratic Regulator (LQR) solution with optimal solutions (minimum time), it is seen that the LQR solution is less than optimal in some cases indeed (3-6) times that obtained using a minimum time solution. Moreover, the LQR solution is sometimes unacceptable in practice due to the fact that values of control extend beyond admissible limits and thus the designer must choose coefficients in the linear quadratic form, which are unknown. The authors suggest methods which allow finding a quasi-optimal LQR solution with bounded control which is closed to the minimum time solution. They also remand the process of the minimum time decision. Keywords: Optimal regulator, minimum time controller, Linear Quadratic Regulator (LQR). -- This paper is declared a work of the U.S. Government and not subject to copyright protection in the USA. The manuscript is accepted as paper AIAA-2003-6638 by 2nd AIAA Unmanned Unlimited Systems, Technologies, and Operations-Aerospace, Land, and See Conference and Workshop - Exhibit, San Diego, California, USA, 15-18 Sep. 2003.

  20. Optimal Cloning and No Signaling

    E-Print Network [OSTI]

    Sibasish Ghosh; Guruprasad Kar; Anirban Roy

    1999-07-01T23:59:59.000Z

    It is shown that no signaling constraint generates the whole class of 1 $\\rightarrow$ 2 optimal quantum cloning machines of single qubits.

  1. Regulation 8: Responsibility for Creation and Amendment of Regulations: REGULATION 8: RESPONSIBILITY FOR CREATION AND AMENDMENT OF

    E-Print Network [OSTI]

    Sussex, University of

    Regulation 8: Responsibility for Creation and Amendment of Regulations: 36 REGULATION 8: RESPONSIBILITY FOR CREATION AND AMENDMENT OF REGULATIONS This Regulation may only be amended at a meeting and revoke Regulations. Regulations may be created, amended and revoked at any meeting of Council. 2

  2. Frequency-dependent electrostatic actuation in microfluidic MEMS.

    SciTech Connect (OSTI)

    Zavadil, Kevin Robert; Michalske, Terry A.; Sounart, Thomas L.

    2003-09-01T23:59:59.000Z

    Electrostatic actuators exhibit fast response times and are easily integrated into microsystems because they can be fabricated with standard IC micromachining processes and materials. Although electrostatic actuators have been used extensively in 'dry' MEMS, they have received less attention in microfluidic systems probably because of challenges such as electrolysis, anodization, and electrode polarization. Here we demonstrate that ac drive signals can be used to prevent electrode polarization, and thus enable electrostatic actuation in many liquids, at potentials low enough to avoid electrochemistry. We measure the frequency response of an interdigitated silicon comb-drive actuator in liquids spanning a decade of dielectric permittivities and four decades of conductivity, and present a simple theory that predicts the characteristic actuation frequency. The analysis demonstrates the importance of the native oxide on silicon actuator response, and suggests that the actuation frequency can be shifted by controlling the thickness of the oxide. For native silicon devices, actuation is predicted at frequencies less than 10 MHz, in electrolytes of ionic strength up to 100 mmol/L, and thus electrostatic actuation may be feasible in many bioMEMS and other microfluidic applications.

  3. Radio-frequency probes of Antarctic ice at South Pole

    E-Print Network [OSTI]

    Besson, David Zeke; Kravchenko, I.

    2013-05-16T23:59:59.000Z

    the 1 1.5 2 2.5 3 3.5 4 0 200 400 600 800 1000 1200 1400 VS WR Frequency (MHz) Horn VSWR Tx SWRRx SWR Fig. 1. Voltage Standing Wave Ratio (VSWR) for both transmitter (Tx) and receiver (Rx) horn used for data taken at South Pole. signal... produce an azimuthal variation in echo strength. The Fresnel zone has a radial extent R roughly given by R ? ? 2?dTxdRx/(dTx + dRx)/2; using ??1 m and dTx ? dRx ?1000 m, we find R ?30 m. Nanosecond scale in- terference effects (the maximum allowed by Fig...

  4. Digital Frequency Domain Multiplexer for mm-Wavelength Telescopes

    SciTech Connect (OSTI)

    Spieler, Helmuth G; Dobbs, Matt; Bissonnette, Eric; Spieler, Helmuth G.

    2007-07-23T23:59:59.000Z

    An FPGA based digital signal processing (DSP) system for biasing and reading out multiplexed bolometric detectors for mm-wavelength telescopes is presented. This readout system is being deployed for balloon-borne and ground based cosmology experiments with the primary goal of measuring the signature of inflation with the Cosmic Microwave Background Radiation. The system consists of analog superconducting electronics running at 250 mK and 4 K, coupled to digital room temperature backend electronics described here. The digital electronics perform the real time functionality with DSP algorithms implemented in firmware. A soft embedded processor provides all of the slow housekeeping control and communications. Each board in the system synthesizes multi-frequency combs of 8 to 32 carriers in the MHz band to bias the detectors. After the carriers have been modulated with the sky-signal by the detectors, the same boards digitize the comb directly. The carriers are mixed down to base-band and low pass filtered. The signal bandwidth of 0.050Hz-100 Hz places extreme requirements on stability and requires powerful filtering techniques to recover the sky-signal from the MHz carriers.

  5. Receptor for advanced glycation end products inhibits proliferation in osteoblast through suppression of Wnt, PI3K and ERK signaling

    SciTech Connect (OSTI)

    Li, Guofeng [Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, Shanghai 200120 (China)] [Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, Shanghai 200120 (China); Xu, Jingren [Department of Traditional Chinese Orthopaedics, East Hospital, Tongji University School of Medicine, Shanghai 200120 (China)] [Department of Traditional Chinese Orthopaedics, East Hospital, Tongji University School of Medicine, Shanghai 200120 (China); Li, Zengchun, E-mail: lizc.2007@yahoo.com.cn [Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, Shanghai 200120 (China)] [Department of Emergency Surgery, East Hospital, Tongji University School of Medicine, Shanghai 200120 (China)

    2012-07-13T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer RAGE overexpression suppresses cell proliferation in MC3T3-E1 cells. Black-Right-Pointing-Pointer RAGE overexpression decreases Wnt/{beta}-catenin signaling. Black-Right-Pointing-Pointer RAGE overexpression decreases ERK and PI3K signaling. Black-Right-Pointing-Pointer Inhibition of Wnt signaling abolishes PI3K signaling restored by RAGE blockade. Black-Right-Pointing-Pointer Inhibition of Wnt signaling abolishes ERK signaling restored by RAGE blockade. -- Abstract: Expression of receptor for advanced glycation end products (RAGE) plays a crucial role in bone metabolism. However, the role of RAGE in the control of osteoblast proliferation is not yet evaluated. In the present study, we demonstrate that RAGE overexpression inhibits osteoblast proliferation in vitro. The negative regulation of RAGE on cell proliferation results from suppression of Wnt, PI3K and ERK signaling, and is restored by RAGE neutralizing antibody. Prevention of Wnt signaling using Sfrp1 or DKK1 rescues RAGE-decreased PI3K and ERK signaling and cell proliferation, indicating that the altered cell growth in RAGE overexpressing cells is in part secondary to alterations in Wnt signaling. Consistently, RAGE overexpression inhibits the expression of Wnt targets cyclin D1 and c-myc, which is partially reversed by RAGE blockade. Overall, these results suggest that RAGE inhibits osteoblast proliferation via suppression of Wnt, PI3K and ERK signaling, which provides novel mechanisms by which RAGE regulates osteoblast growth.

  6. Aalborg Universitet Frequency Stability of Hierarchically Controlled Hybrid Photovoltaic-Battery-

    E-Print Network [OSTI]

    Vasquez, Juan Carlos

    sharing among PV voltage source inverters (VSIs), while injecting the dispatched power to the main grid as well. However, the different resources with conventional constant P/Q and P/V controls coexisting. Further, frequency stability analysis is presented based on small signal models of the hybrid PV

  7. A Frequency-Reconfigurable Circularly Polarized Patch Antenna by Integrating MEMS Switches

    E-Print Network [OSTI]

    De Flaviis, Franco

    operation and higher Q, which inherently fits the antenna element. In this manuscript, a novel circularly permittivity = 3.78 and width = 38.1mm). 10 switches are monolithically integrated into the patch with 1 mm are used as matching network at both frequencies. To provide isolation between the RF signal and the DC

  8. A Comparative Study of Time-Frequency Representations for Fault Detection in Wind Turbine

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    A Comparative Study of Time-Frequency Representations for Fault Detection in Wind Turbine El of wind energy, minimization and prediction of maintenance operations in wind turbine is of key importance. In variable speed turbine generator, advanced signal processing tools are required to detect and diagnose

  9. Mel-Frequency Cepstral Coefficient-Based Bandwidth Extension of Narrowband Speech

    E-Print Network [OSTI]

    Kabal, Peter

    for the Bandwidth Extension (BWE) of narrowband speech. BWE is based on the assumption that narrowband speech (0 of the highband frequency content given the narrow band. While BWE schemes have traditionally used LP which the time-domain speech signal can be reconstructed. Implementing this scheme for BWE translates

  10. Interrelationship of Program Regulations and Financial Assistance Regulations

    Broader source: Directives, Delegations, and Requirements [Office of Management (MA)]

    1980-04-24T23:59:59.000Z

    The purpose of this Order is to set forth the interrelationship between all program regulations which will result in assistance awards (Program Regulations) and the Department of Energy Assistance Regulations (DOE-AR, 10 CRF Part 600), including procedures for exceptions, deviations or waivers.

  11. Surface Coal Mining Regulations (Mississippi)

    Broader source: Energy.gov [DOE]

    The Surface Coal Mining Regulations are a combination of permitting requirements and environmental regulations that limit how, where and when coal can be mined. It protects lands that are under...

  12. Corporate governance and banking regulation

    E-Print Network [OSTI]

    Alexander, Kern

    The globalisation of banking markets has raised important issues regarding corporate governance regulation for banking institutions. This research paper addresses some of the major issues of corporate governance as it relates to banking regulation...

  13. Hazardous Waste Management Regulations (Mississippi)

    Broader source: Energy.gov [DOE]

    The Hazardous Waste Management Regulations follow the EPA's definitions and guidelines for the most part, which are listed in 40 CFR parts 260-282. In addition to these federal regulations the...

  14. California Energy Commission PROPOSED REGULATIONS

    E-Print Network [OSTI]

    California Energy Commission PROPOSED REGULATIONS INITIAL STATEMENT OF REASONS FOR ENFORCEMENT CEC3002013004 CALIFORNIA ENERGY COMMISSION Edmund G. Brown, Jr., Governor #12;#12;1 INITIAL STATEMENT OF REASONS PROPOSED REGULATIONS ENFORCEMENT PROCEDURES FOR THE RENEWABLES PORTFOLIO STANDARD

  15. Systemic Signalling in Plant Development

    E-Print Network [OSTI]

    Jackson, David

    develop continuously throughout their life cycle, constantly initiating new or- gans. They doSystemic Signalling in Plant Development David Jackson, Cold Spring Harbor Laboratory, Cold Spring to the production of systemic signals that control the development of distant organs and tissues. Introduction

  16. MARQUETTE UNIVERSITY Speech Signal Enhancement

    E-Print Network [OSTI]

    Johnson, Michael T.

    MARQUETTE UNIVERSITY Speech Signal Enhancement Using A Microphone Array A THESIS SUBMITTED Reserved #12;iii Preface This thesis describes the design and implementation of a speech enhancement system that uses microphone array beamforming and speech enhancement algorithms applied to a speech signal

  17. CWN-1 functions with DSH-2 to regulate C. elegans asymmetric neuroblast division in a -catenin independent Wnt pathway

    E-Print Network [OSTI]

    Hardin, Jeff

    . elegans Dishevelled (Dsh) homolog, DSH-2, regulates asymmetric neuroblast division of the ABpl/rpppa blast homolog, cwn-1, functions to regulate asymmetric division of the ABpl/rpppa blast cell. Our results. The transcriptional response mediated by -catenin represents an important effect of Wnt signaling

  18. Land Use Regulation with Durable Capital

    E-Print Network [OSTI]

    Quigley, John M.; Swoboda, Aaron

    2009-01-01T23:59:59.000Z

    Manhattan so expensive? Regulation and the rise of housingmotive for restrictive regulation by local home owners.the impacts of these regulations vary across owner- occupied

  19. Prenatal maternal stress programs infant stress regulation.

    E-Print Network [OSTI]

    Davis, Elysia Poggi; Glynn, Laura M; Waffarn, Feizal; Sandman, Curt A

    2011-01-01T23:59:59.000Z

    Programs Infant Stress Regulation Elysia Poggi Davis, PhDglucocorticoids disrupts the regulation of physiological andstress alters circadian regulation and laboratory levels of

  20. Price regulation for waste hauling franchises in California: an examination of how regulators regulate pricing and the effects of competition on regulated markets

    E-Print Network [OSTI]

    Seltzer, Steven A.

    2011-01-01T23:59:59.000Z

    Thomadakis, Stavros. “Price Regulation Under Uncertainty inin the Theory of Regulation. ” Handbook of IndustrialMark and David Sappington. “Regulation, Competition and

  1. Essays on the politics of regulation

    E-Print Network [OSTI]

    Weymouth, Stephen

    2010-01-01T23:59:59.000Z

    F. , 2002: Does entry regulation hinder job creation? evi-Macroeconomic effects of regulation and dereg- ulation inand Shleifer, A. , 2004: The regulation of labor. Quarterly

  2. Nanotechnology Regulation: A Study in Claims Making

    E-Print Network [OSTI]

    Malloy, Timothy F.

    2011-01-01T23:59:59.000Z

    Nanomaterials: Principles, Regulation, and Renegotiating theJoseph Rees, Industry Self-Regulation: An InstitutionalDarren Sinclair, Self-Regulation Versus Command and Control?

  3. Regulation, Unemployment, and Cost-Benefit Analysis

    E-Print Network [OSTI]

    Posner, Eric; Masur, Jonathan S.

    2011-01-01T23:59:59.000Z

    and Eric A. Posner, Regulation, Unemployment, and Cost-effects of environmental regulations for other industries.Paper Collection.   Regulation, Unemployment, and Cost-

  4. Energy Efficiency in Regulated and Deregulated Markets

    E-Print Network [OSTI]

    Rotenberg, Edan

    2005-01-01T23:59:59.000Z

    establishing what energy efficiency, regulation, and der-policy justifications for energy efficiency regulations. Thesector. ENERGY EFFICIENCY UNDER REGULATION This section

  5. An in situ measurement of the radio-frequency attenuation in ice at Summit Station, Greenland

    E-Print Network [OSTI]

    J. Avva; J. M. Kovac; C. Miki; D. Saltzberg; A. G. Vieregg

    2014-09-30T23:59:59.000Z

    We report an in situ measurement of the electric field attenuation length at radio frequencies for the bulk ice at Summit Station, Greenland, made by broadcasting radio-frequency signals vertically through the ice and measuring the relative power in the return ground bounce signal. We find the depth-averaged field attenuation length to be 947 +92/-85 meters at 75 MHz. While this measurement has clear radioglaciological applications, the radio clarity of the ice also has implications for the detection of ultra-high energy (UHE) astrophysical particles via their radio emission in dielectric media such as ice. The measured attenuation length at Summit Station is comparable to previously measured radio-frequency attenuation lengths at candidate particle detector sites around the world, and strengthens the case for Summit Station as the most promising northern site for UHE neutrino detection.

  6. Square Kilometer Array Telescope - Precision Reference Frequency Synchronisation via 1f-2f Dissemination

    E-Print Network [OSTI]

    Wang, B; Gao, C; Bai, Y; Dong, J W; Wang, L J

    2015-01-01T23:59:59.000Z

    The Square Kilometer Array (SKA) is an international effort to build the world's largest radio telescope, with one square kilometer collecting area. Besides its ambitious scientific objectives, such as probing the cosmic dawn and cradle of life, SKA also demands several revolutionary technological breakthroughs, with ultra-high precision synchronisation of the frequency references for thousands of antennas being one of them. In this report, aimed at applications to SKA, we demonstrate a frequency reference synchronization and dissemination scheme with the phase noise compensation function placed at the client site. Hence, one central hub can be linked to a large number of client sites, forming a star-shaped topology. As a performance test, the 100 MHz reference signal from a Hydrogen maser clock is disseminated and recovered at two remote sites. Phase noise characteristics of the recovered reference frequency signal coincides with that of the hydrogen-maser source and satisfies SKA requirement.

  7. Design and initial characterization of a compact, ultra high vacuum compatible, low frequency, tilt accelerometer

    SciTech Connect (OSTI)

    O’Toole, A., E-mail: amandajotoole@gmail.com, E-mail: riccardo.desalvo@gmail.com [Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, 405 Hilgard Ave, Los Angeles, California 90095 (United States); Peña Arellano, F. E. [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Rodionov, A. V.; Kim, C. [California Institute of Technology, Pasadena, California 91125 (United States); Shaner, M.; Asadoor, M. [Mayfield Senior School, 500 Bellefontaine Street Pasadena, California 91105 (United States); Sobacchi, E. [Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa (Italy); Dergachev, V.; DeSalvo, R., E-mail: amandajotoole@gmail.com, E-mail: riccardo.desalvo@gmail.com [LIGO Laboratory, California Institute of Technology, MS 100-36, Pasadena, California 91125 (United States); Bhawal, A. [Arcadia High School, 180 Campus Drive, Arcadia, California 91007 (United States); Gong, P. [Department of Precision Instrument, Tsinghua University, Beijing 100084 (China); Lottarini, A. [Department of Computer Science, University of Pisa, Largo B. Pontecorvo 3, 56127 Pisa (Italy); Minenkov, Y. [Sezione INFN Tor Vergata, via della Ricerca Scientfica 1, 00133 Roma (Italy); Murphy, C. [School of Physics, The University of Western Australia, 35 Stirling Highway, Crawley, Perth, Western Australia 6009 (Australia)

    2014-07-15T23:59:59.000Z

    A compact tilt accelerometer with high sensitivity at low frequency was designed to provide low frequency corrections for the feedback signal of the Advanced Laser Interferometer Gravitational Wave Observatory active seismic attenuation system. It has been developed using a Tungsten Carbide ceramic knife-edge hinge designed to avoid the mechanical 1/f noise believed to be intrinsic in polycrystalline metallic flexures. Design and construction details are presented; prototype data acquisition and control limitations are discussed. The instrument's characterization reported here shows that the hinge is compatible with being metal-hysteresis-free, and therefore also free of the 1/f noise generated by the dislocation Self-Organized Criticality in the metal. A tiltmeter of this kind will be effective to separate the ground tilt component from the signal of horizontal low frequency seismometers, and to correct the ill effects of microseismic tilt in advanced seismic attenuation systems.

  8. Cogeneration and its regulations

    SciTech Connect (OSTI)

    Casten, T.R.; Ross, H.E.

    1981-03-26T23:59:59.000Z

    In the near term, regulators, utility managements, and legislators will grapple with numerous issues surrounding the development of cogeneration projects as sources of electric power. The Federal Energy Regulatory Commission predicts that 12,000 MW of new cogeneration plants will be constructed during the 1980s, and all 50 states are in the process of implementing new regulations pursuant to the Public Utility Regulatory Policies Act. The US utility system's overall fuel efficiency of 29% offers rich opportunities to conserve fuel, reduce costs, and decrease pollution via cogeneration. Policymakers should stop viewing utilities simply as efficiency tax collectors on the one hand and opponents of innovation on the other. In addition to mothballing inefficient central utility stations, the US must rapidly deploy district heating with cogenerated heat; policymakers should look beyond the obsolete stream systems and encourage development of the high-temperature hot-water systems so successful in Europe.

  9. Temperature controlled high voltage regulator

    DOE Patents [OSTI]

    Chiaro, Jr., Peter J. (Clinton, TN); Schulze, Gerald K. (Knoxville, TN)

    2004-04-20T23:59:59.000Z

    A temperature controlled high voltage regulator for automatically adjusting the high voltage applied to a radiation detector is described. The regulator is a solid state device that is independent of the attached radiation detector, enabling the regulator to be used by various models of radiation detectors, such as gas flow proportional radiation detectors.

  10. Emotion Regulation JAMES J. GROSS

    E-Print Network [OSTI]

    Gross, James J.

    CHAPTER 31 ·Emotion Regulation JAMES J. GROSS Have you ever gotten so angry that you've done). Although the topic of emotion regulation is a relatively late addition to the field of emotion, a concern with emotion regulation is anything but new. Emotion regu lation has been a focus in the study of psycho

  11. Army Regulation 2001 Environmental Quality

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Army Regulation 200­1 Environmental Quality Environmental Protection and Enhancement Headquarters Environmental Protection and Enhancement *Army Regulation 200­1 Effective 27 December 2007 History in the summary of change. Summary. This regulation covers envi- ronmental protection and enhancement and provides

  12. REGULATION AND DISTRUST Philippe AGHION

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    REGULATION AND DISTRUST Philippe AGHION Yann ALGAN Pierre CAHUC Andrei SHLEIFER January 2009 Cahier://www.enseignement.polytechnique.fr/economie/ mailto:chantal.poujouly@polytechnique.edu hal-00396268,version1-17Jun2009 #12;REGULATION AND DISTRUST1: In a cross-section of countries, government regulation is strongly negatively correlated with social capital

  13. Improving CS regulations.

    SciTech Connect (OSTI)

    Nesse, R.J.; Scheer, R.M.; Marasco, A.L.; Furey, R.

    1980-10-01T23:59:59.000Z

    President Carter issued Executive Order 12044 (3/28/78) that required all Federal agencies to distinguish between significant and insignificant regulations, and to determine whether a regulation will result in major impacts. This study gathered information on the impact of the order and the guidelines on the Office of Conservation and Solar Energy (CS) regulatory practices, investigated problems encountered by the CS staff when implementing the order and guidelines, and recommended solutions to resolve these problems. Major tasks accomplished and discussed are: (1) legislation, Executive Orders, and DOE Memoranda concerning Federal administrative procedures relevant to the development and analysis of regulations within CS reviewed; (2) relevant DOE Orders and Memoranda analyzed and key DOE and CS staff interviewed in order to accurately describe the current CS regulatory process; (3) DOE staff from the Office of the General Counsel, the Office of Policy and Evaluation, the Office of the Environment, and the Office of the Secretary interviewed to explore issues and problems encountered with current CS regulatory practices; (4) the regulatory processes at five other Federal agencies reviewed in order to see how other agencies have approached the regulatory process, dealt with specific regulatory problems, and responded to the Executive Order; and (5) based on the results of the preceding four tasks, recommendations for potential solutions to the CS regulatory problems developed. (MCW)

  14. Signal Flows in Non-Markovian Linear Quantum Feedback Networks

    E-Print Network [OSTI]

    Re-Bing Wu; Jing Zhang; Yu-xi Liu; Tzyh-Jong Tarn

    2014-12-17T23:59:59.000Z

    Enabled by rapidly developing quantum technologies, it is possible to network quantum systems at a much larger scale in the near future. To deal with non-Markovian dynamics that is prevalent in solid-state devices, we propose a general transfer function based framework for modeling linear quantum networks, in which signal flow graphs are applied to characterize the network topology by flow of quantum signals. We define a noncommutative ring $\\mathbb{D}$ and use its elements to construct Hamiltonians, transformations and transfer functions for both active and passive systems. The signal flow graph obtained for direct and indirect coherent quantum feedback systems clearly show the feedback loop via bidirectional signal flows. Importantly, the transfer function from input to output field is derived for non-Markovian quantum systems with colored inputs, from which the Markovian input-output relation can be easily obtained as a limiting case. Moreover, the transfer function possesses a symmetry structure that is analogous to the well-know scattering transformation in \\sd picture. Finally, we show that these transfer functions can be integrated to build complex feedback networks via interconnections, serial products and feedback, which may include either direct or indirect coherent feedback loops, and transfer functions between quantum signal nodes can be calculated by the Riegle's matrix gain rule. The theory paves the way for modeling, analyzing and synthesizing non-Markovian linear quantum feedback networks in the frequency-domain.

  15. SU-E-I-52: Validation of Multi-Frequency Electrical Impedance Tomography Using Computed Tomography

    SciTech Connect (OSTI)

    Kohli, K; Liu, F; Krishnan, K [BC Cancer Agency, Surrey, BC (United Kingdom)

    2014-06-01T23:59:59.000Z

    Purpose: Multi-frequency EIT has been reported to be a potential tool in distinguishing a tissue anomaly from background. In this study, we investigate the feasibility of acquiring functional information by comparing multi-frequency EIT images in reference to the structural information from the CT image through fusion. Methods: EIT data was acquired from a slice of winter melon using sixteen electrodes around the phantom, injecting a current of 0.4mA at 100, 66, 24.8 and 9.9 kHz. Differential EIT images were generated by considering different combinations of pair frequencies, one serving as reference data and the other as test data. The experiment was repeated after creating an anomaly in the form of an off-centered cavity of diameter 4.5 cm inside the melon. All EIT images were reconstructed using Electrical Impedance Tomography and Diffuse Optical Tomography Reconstruction Software (EIDORS) package in 2-D differential imaging mode using one-step Gaussian Newton minimization solver. CT image of the melon was obtained using a Phillips CT Scanner. A segmented binary mask image was generated based on the reference electrode position and the CT image to define the regions of interest. The region selected by the user was fused with the CT image through logical indexing. Results: Differential images based on the reference and test signal frequencies were reconstructed from EIT data. Result illustrated distinct structural inhomogeneity in seeded region compared to fruit flesh. The seeded region was seen as a higherimpedance region if the test frequency was lower than the base frequency in the differential EIT reconstruction. When the test frequency was higher than the base frequency, the signal experienced less electrical impedance in the seeded region during the EIT data acquisition. Conclusion: Frequency-based differential EIT imaging can be explored to provide additional functional information along with structural information from CT for identifying different tissues.

  16. Coordination of Voltage and Frequency Feedback in Load-Frequency Control Capability of Wind Turbine

    E-Print Network [OSTI]

    Silva, Filipe Faria Da

    Coordination of Voltage and Frequency Feedback in Load-Frequency Control Capability of Wind Turbine-Frequency Control (LFC) is gradually shifted to Variable Speed Wind Turbines (VSWTs). In order to equip VSWT

  17. Development of mass spectrometry based technologies for quantitative cell signaling phosphoproteomics : the epidermal growth factor receptor family as a model system

    E-Print Network [OSTI]

    Wolf Yadlin, Alejandro

    2007-01-01T23:59:59.000Z

    Ligand binding to cell surface receptors initiates a cascade of signaling events regulated by dynamic phosphorylation on a multitude of pathway proteins. Quantitative features, including intensity, timing, and duration of ...

  18. Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

    E-Print Network [OSTI]

    Lauffenburger, Douglas A.

    The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis. Nonetheless, it remains poorly understood ...

  19. Terminality implies non-signalling

    E-Print Network [OSTI]

    Bob Coecke

    2014-12-30T23:59:59.000Z

    A 'process theory' is any theory of systems and processes which admits sequential and parallel composition. `Terminality' unifies normalisation of pure states, trace-preservation of CP-maps, and adding up to identity of positive operators in quantum theory, and generalises this to arbitrary process theories. We show that terminality and non-signalling coincide in any process theory, provided one makes causal structure explicit. In fact, making causal structure explicit is necessary to even make sense of non-signalling in process theories. We conclude that because of its much simpler mathematical form, terminality should be taken to be a more fundamental notion than non-signalling.

  20. Time-domain analysis of a dynamically tuned signal recycled interferometer for the detection of chirp gravitational waves from coalescing compact binaries

    E-Print Network [OSTI]

    D. A. Simakov

    2015-04-28T23:59:59.000Z

    In this article we study a particular method of detection of chirp signals from coalescing compact binary stars -- the so-called dynamical tuning, i.e. amplification of the signal via tracking of its instantaneous frequency by the tuning of the signal-recycled detector. A time-domain consideration developed for signal-recycled interferometers, in particular GEO 600, describes the signal and noise evolution in the non-stationary detector. Its non-stationarity is caused by motion of the signal recycling mirror, whose position defines the tuning of the detector. We prove that the shot noise from the dark port and optical losses remains white. The analysis of the transient effects shows that during the perfect tracking of the chirp frequency only transients from amplitude changes arise. The signal-to-noise-ratio gain, calculated in this paper, is ~ 16 for a shot-noise limited detector and ~ 4 for a detector with thermal noise.

  1. Frequency synthesis using MEMS piezoelectric resonators

    E-Print Network [OSTI]

    Calhoun, Paul Jacob, 1979-

    2004-01-01T23:59:59.000Z

    (cont.) Ultimately, this thesis presents two approaches to frequency synthesizer design. The first uses frequency windows of approximately 200 MHz. The 800 MHz to 1 GHz matching network is presented in detail along with ...

  2. FREQUENCY DEPENDENT MULTIPOLE POLARIZABILITIES OF ATOMIC SYSTEMS

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1259 FREQUENCY DEPENDENT MULTIPOLE POLARIZABILITIES OF ATOMIC SYSTEMS S. I. EASA and G. C. SHUKLA et d'helium. Abstract. 2014 A variational calculation for frequency dependent multipole 1978, Classification Physics Abstracts 31.10 The calculation of multipole polarizabilities

  3. certification, compliance and enforcement regulations for Commercial...

    Office of Environmental Management (EM)

    certification, compliance and enforcement regulations for Commercial Refrigeration Equipment (CRE) certification, compliance and enforcement regulations for Commercial...

  4. Neural networks and separation of Cosmic Microwave Background and astrophysical signals in sky maps

    E-Print Network [OSTI]

    C. Baccigalupi; L. Bedini; C. Burigana; G. De Zotti; A. Farusi; D. Maino; M. Maris; F. Perrotta; E. Salerno; L. Toffolatti; A. Tonazzini

    2000-06-21T23:59:59.000Z

    The Independent Component Analysis (ICA) algorithm is implemented as a neural network for separating signals of different origin in astrophysical sky maps. Due to its self-organizing capability, it works without prior assumptions on the signals, neither on their frequency scaling, nor on the signal maps themselves; instead, it learns directly from the input data how to separate the physical components, making use of their statistical independence. To test the capabilities of this approach, we apply the ICA algorithm on sky patches, taken from simulations and observations, at the microwave frequencies, that are going to be deeply explored in a few years on the whole sky, by the Microwave Anisotropy Probe (MAP) and by the {\\sc Planck} Surveyor Satellite. The maps are at the frequencies of the Low Frequency Instrument (LFI) aboard the {\\sc Planck} satellite (30, 44, 70 and 100 GHz), and contain simulated astrophysical radio sources, Cosmic Microwave Background (CMB) radiation, and Galactic diffuse emissions from thermal dust and synchrotron. We show that the ICA algorithm is able to recover each signal, with precision going from 10% for the Galactic components to percent for CMB; radio sources are almost completely recovered down to a flux limit corresponding to $0.7\\sigma_{CMB}$, where $\\sigma_{CMB}$ is the rms level of CMB fluctuations. The signal recovering possesses equal quality on all the scales larger then the pixel size. In addition, we show that the frequency scalings of the input signals can be partially inferred from the ICA outputs, at the percent precision for the dominant components, radio sources and CMB.

  5. Methods for detection and characterization of signals in noisy data with the Hilbert-Huang Transform

    E-Print Network [OSTI]

    Alexander Stroeer; John K. Cannizzo; Jordan B. Camp; Nicolas Gagarin

    2009-03-26T23:59:59.000Z

    The Hilbert-Huang Transform is a novel, adaptive approach to time series analysis that does not make assumptions about the data form. Its adaptive, local character allows the decomposition of non-stationary signals with hightime-frequency resolution but also renders it susceptible to degradation from noise. We show that complementing the HHT with techniques such as zero-phase filtering, kernel density estimation and Fourier analysis allows it to be used effectively to detect and characterize signals with low signal to noise ratio.

  6. Broadband squeezing of quantum noise in a Michelson interferometer with Twin-Signal-Recycling

    E-Print Network [OSTI]

    André Thüring; Christian Gräf; Henning Vahlbruch; Moritz Mehmet; Karsten Danzmann; Roman Schnabel

    2010-05-25T23:59:59.000Z

    Twin-Signal-Recycling (TSR) builds on the resonance doublet of two optically coupled cavities and efficiently enhances the sensitivity of an interferometer at a dedicated signal frequency. We report on the first experimental realization of a Twin-Signal-Recycling Michelson interferometer and also its broadband enhancement by squeezed light injection. The complete setup was stably locked and a broadband quantum noise reduction of the interferometers shot noise by a factor of up to 4\\,dB was demonstrated. The system was characterized by measuring its quantum noise spectra for several tunings of the TSR cavities. We found good agreement between the experimental results and numerical simulations.

  7. Radiolocation using AM broadcast signals

    E-Print Network [OSTI]

    Hall, Timothy Douglas, 1970-

    2002-01-01T23:59:59.000Z

    (cont.) Previous attempts at signal-of-opportunity navigation using carrier phase sidestepped the ambiguity problem by requiring that the initial position of the rover be known and that phase variations be tracked without ...

  8. Automated classification of power signals

    E-Print Network [OSTI]

    Proper, Ethan R. (Ethan Richard)

    2008-01-01T23:59:59.000Z

    The Non-Intrusive Load Monitor (NILM) is a device that utilizes voltage and current measurements to monitor an entire system from a single reference point. The NILM and associated software convert the V/I signal to spectral ...

  9. The Effects of the Ionosphere and C/A Frequency on GPS Signal Shape

    E-Print Network [OSTI]

    Stanford University

    is only capable of removing 50-60% of the error. Jock R. I. Christie is a Ph.D. Candidate in a Taylor Series about L1, the first two terms of this model lead to code-carrier divergence. The next term the NASA Advisory Council and is on the Vice President's Committee on Aviation Safety and Security. He

  10. A quasi periodic signal with ultra low frequency discovered in V0332+53?

    E-Print Network [OSTI]

    Shu Zhang; Diego F. Torres; JinLu Qu

    2006-08-18T23:59:59.000Z

    The reported likely QPO is found to be an instrumental effect, which was never clarified in any INTEGRAL related literatures. The paper should therfore be withdrawn.

  11. Continuous-Time Digital Signal Processing Based Controller for High-Frequency DC-DC Converters

    E-Print Network [OSTI]

    Prodiæ, Aleksandar

    control have been recognized (flexibility, design portability, simple implementation of power management power switch on/off time is calculated from capacitor charge balance to prevent large overshoots's College Road, Toronto, ON, M5S 3G4, CANADA E-mail: Zhenyu @ power.utoronto.ca, vsmolyakov@ hotmail

  12. TIME-FREQUENCY-PHASE TRACKING APPROACH : APPLICATION TO UNDERWATER SIGNALS IN A PASSIVE CONTEXT

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    of Montenegro, Podgorica ­ MONTENEGRO E-mail : srdjan@cg.ac.yu ABSTRACT One of the most challenging applications

  13. Observation of acoustical signal fluctuations by time-frequency analysis methods

    E-Print Network [OSTI]

    Jesus, Sérgio M.

    . Bozzoa , S. Jesusb , J. Onofrec , P. Piccod , and A. Truccoa a Department of Biophysical and Electronic Engineering (DIBE), University of Genoa, Via all'Opera Pia 11A, I-16145 Genoa, Italy, e-mail:trucco@ieee.org b energy levels. In [1] Apel et al. have shown that internal waves activity, strongly dependent upon time

  14. High contrast modulation of plasmonic signals using nanoscale dual-frequency liquid crystals

    E-Print Network [OSTI]

    status," Laser Photon. Rev. 4, 527­532 (2010). 4. J. Dionne, L. Sweatlock, M. Sheldon, P. Alivisatos

  15. Self-regulating valve

    DOE Patents [OSTI]

    Humphreys, D.A.

    1982-07-20T23:59:59.000Z

    A variable, self-regulating valve having a hydraulic loss coefficient proportional to a positive exponential power of the flow rate. The device includes two objects in a flow channel and structure which assures that the distance between the two objects is an increasing function of the flow rate. The range of spacing between the objects is such that the hydraulic resistance of the valve is an increasing function of the distance between the two objects so that the desired hydraulic loss coefficient as a function of flow rate is obtained without variation in the flow area.

  16. Calpain-mediated proteolysis of polycystin-1 C-terminus induces JAK2 and ERK signal alterations

    SciTech Connect (OSTI)

    Kim, Hyunho [Transplantation Research Institute, Seoul National University Medical Research Center, Seoul (Korea, Republic of); Department of Medicine, University of Maryland, Baltimore, MD (United States); Kang, Ah-Young [Transplantation Research Institute, Seoul National University Medical Research Center, Seoul (Korea, Republic of); Department of Medicine, Program of Immunology, Graduate School, Seoul National University, Seoul (Korea, Republic of); Ko, Ah-ra [Clinical Research Center, Samsung Biomedical Research Institute, Seoul (Korea, Republic of); Park, Hayne Cho [Transplantation Research Institute, Seoul National University Medical Research Center, Seoul (Korea, Republic of); Research Coordination Center for Rare Diseases, Seoul National University Hospital, Seoul (Korea, Republic of); So, Insuk [Department of Physiology, Seoul National University College of Medicine, Seoul (Korea, Republic of); Park, Jong Hoon [Department of Biological Science, Sookmyung Women’s University, Seoul (Korea, Republic of); Cheong, Hae Il [Research Coordination Center for Rare Diseases, Seoul National University Hospital, Seoul (Korea, Republic of); Department of Pediatrics, Seoul National University Children’s Hospital, Seoul (Korea, Republic of); Kidney Research Institute, Medical Research Center, Seoul National University College of Medicine, Seoul (Korea, Republic of); Hwang, Young-Hwan [Research Coordination Center for Rare Diseases, Seoul National University Hospital, Seoul (Korea, Republic of); Department of Internal Medicine, Eulji General Hospital, Eulji University College of Medicine, Seoul (Korea, Republic of); and others

    2014-01-01T23:59:59.000Z

    Autosomal dominant polycystic kidney disease (ADPKD), a hereditary renal disease caused by mutations in PKD1 (85%) or PKD2 (15%), is characterized by the development of gradually enlarging multiple renal cysts and progressive renal failure. Polycystin-1 (PC1), PKD1 gene product, is an integral membrane glycoprotein which regulates a number of different biological processes including cell proliferation, apoptosis, cell polarity, and tubulogenesis. PC1 is a target of various proteolytic cleavages and proteosomal degradations, but its role in intracellular signaling pathways remains poorly understood. Herein, we demonstrated that PC1 is a novel substrate for ?- and m-calpains, which are calcium-dependent cysteine proteases. Overexpression of PC1 altered both Janus-activated kinase 2 (JAK2) and extracellular signal-regulated kinase (ERK) signals, which were independently regulated by calpain-mediated PC1 degradation. They suggest that the PC1 function on JAK2 and ERK signaling pathways might be regulated by calpains in response to the changes in intracellular calcium concentration. - Highlights: • Polycystin-1 is a target of ubiquitin-independent degradation by calpains. • The PEST domain is required for calpain-mediated degradation of polycystin-1. • Polycystin-1 may independently regulate JAK2 and ERK signaling pathways.

  17. System and method for regulating resonant inverters

    DOE Patents [OSTI]

    Stevanovic, Ljubisa Dragoljub (Clifton Park, NY); Zane, Regan Andrew (Superior, CO)

    2007-08-28T23:59:59.000Z

    A technique is provided for direct digital phase control of resonant inverters based on sensing of one or more parameters of the resonant inverter. The resonant inverter control system includes a switching circuit for applying power signals to the resonant inverter and a sensor for sensing one or more parameters of the resonant inverter. The one or more parameters are representative of a phase angle. The resonant inverter control system also includes a comparator for comparing the one or more parameters to a reference value and a digital controller for determining timing of the one or more parameters and for regulating operation of the switching circuit based upon the timing of the one or more parameters.

  18. ANRV288-CB22-19 ARI 25 June 2006 14:55 Intracellular Signaling

    E-Print Network [OSTI]

    Walter, Peter

    reticulum stress, signal transduction, organelle homeostasis, protein folding, regulated mRNA splicing triggers an exten- sive transcriptional response, which adjusts the ER protein folding capacity according to reestablish homeostasis in the cell's protein folding capacity or--if this cannot be achieved-- commit cells

  19. TGF-b activates Erk MAP kinase signalling through direct phosphorylation of ShcA

    E-Print Network [OSTI]

    Derynck, Rik

    TGF-b activates Erk MAP kinase signalling through direct phosphorylation of ShcA Matt K Lee1, *, Ce Hospital Los Angeles, University of Southern California, CA, USA Erk1/Erk2 MAP kinases are key regulators, TGF-b stimulation also activates Erk MAP kinases through an undefined mechanism, albeit to a much

  20. Phosphate stimulates Matrix Gla Protein expression in chondrocytes through the ERK signaling pathway

    E-Print Network [OSTI]

    Boyer, Edmond

    1 Phosphate stimulates Matrix Gla Protein expression in chondrocytes through the ERK signaling. Email: Jerome.guicheux@nantes.inserm.fr Short title Phosphate stimulates MGP expression via ERK-regulated kinase 1 and 2 (ERK1/2) was performed in rib organ cultures from newborn mice. Results indicated that Pi

  1. ERK Signaling in the Pituitary Is Required for Female But Not Male Fertility

    E-Print Network [OSTI]

    ERK Signaling in the Pituitary Is Required for Female But Not Male Fertility Stuart P. Bliss. Several studies suggest that ERK1 and -2 are essential modulators of hypothalamic GnRH-mediated regulation-specific depletion of ERK1 and 2 and examined a range of physiological parameters including fertility. We find

  2. A central integrator of transcription networks in plant stress and energy signalling

    E-Print Network [OSTI]

    Sheen, Jen

    are the principal solar energy converter sustaining life on Earth. Despite its fundamental importance, little to globally regulate plant metabolism, energy balance, growth and survival. In con- trast to the prevailingLETTERS A central integrator of transcription networks in plant stress and energy signalling Elena

  3. Spatio-mechanical EphA2/ephrin-A1 Signaling in Cancer Cells

    E-Print Network [OSTI]

    Xu, Qian

    2011-01-01T23:59:59.000Z

    12 EphA2 signal regulation in MDA-MB-231 cells has spatio-26 MDA-MB-231 cells are sensitive to the presence ofEphA2 on the surface of MDA-MB-231 human breast cancer

  4. Evolving a robust signal transduction pathway from weak cross-talk

    E-Print Network [OSTI]

    Siryaporn, Albert

    We have evolved a robust two?component signal transduction pathway from a sensor kinase (SK) and non?partner response regulator (RR) that show weak cross?talk in vitro and no detectable cross?talk in vivo in wild?type ...

  5. Evolving a robust signal transduction pathway from weak cross-talk

    E-Print Network [OSTI]

    Siryaporn, Albert

    We have evolved a robust two-component signal transduction pathway from a sensor kinase (SK) and non-partner response regulator (RR) that show weak cross-talk in vitro and no detectable cross-talk in vivo in wild-type ...

  6. Low frequency ac waveform generator

    DOE Patents [OSTI]

    Bilharz, O.W.

    1983-11-22T23:59:59.000Z

    Low frequency sine, cosine, triangle and square waves are synthesized in circuitry which allows variation in the waveform amplitude and frequency while exhibiting good stability and without requiring significant stablization time. A triangle waveform is formed by a ramped integration process controlled by a saturation amplifier circuit which produces the necessary hysteresis for the triangle waveform. The output of the saturation circuit is tapped to produce the square waveform. The sine waveform is synthesized by taking the absolute value of the triangular waveform, raising this absolute value to a predetermined power, multiplying the raised absolute value of the triangle wave with the triangle wave itself and properly scaling the resultant waveform and subtracting it from the triangular waveform to a predetermined power and adding the squared waveform raised to the predetermined power with a DC reference and subtracting the squared waveform therefrom, with all waveforms properly scaled. The resultant waveform is then multiplied with a square wave in order to correct the polarity and produce the resultant cosine waveform.

  7. Low frequency AC waveform generator

    DOE Patents [OSTI]

    Bilharz, Oscar W. (Scotia, NY)

    1986-01-01T23:59:59.000Z

    Low frequency sine, cosine, triangle and square waves are synthesized in circuitry which allows variation in the waveform amplitude and frequency while exhibiting good stability and without requiring significant stabilization time. A triangle waveform is formed by a ramped integration process controlled by a saturation amplifier circuit which produces the necessary hysteresis for the triangle waveform. The output of the saturation circuit is tapped to produce the square waveform. The sine waveform is synthesized by taking the absolute value of the triangular waveform, raising this absolute value to a predetermined power, multiplying the raised absolute value of the triangle wave with the triangle wave itself and properly scaling the resultant waveform and subtracting it from the triangular waveform itself. The cosine is synthesized by squaring the triangular waveform, raising the triangular waveform to a predetermined power and adding the squared waveform raised to the predetermined power with a DC reference and subtracting the squared waveform therefrom, with all waveforms properly scaled. The resultant waveform is then multiplied with a square wave in order to correct the polarity and produce the resultant cosine waveform.

  8. Frequency stabilization of a 1083 nm fiber laser to {sup 4}He transition lines with optical heterodyne saturation spectroscopies

    SciTech Connect (OSTI)

    Gong, W.; Peng, X., E-mail: xiangpeng@pku.edu.cn; Li, W.; Guo, H., E-mail: hongguo@pku.edu.cn [State Key Laboratory of Advanced Optical Communication Systems and Networks, School of Electronics Engineering and Computer Science, Center for Quantum Information Technology, and Center for Computational Science and Engineering (CCSE), Peking University, Beijing 100871 (China)

    2014-07-15T23:59:59.000Z

    Two kinds of optical heterodyne saturation spectroscopies, namely, frequency modulation spectroscopy (FMS) and modulation transfer spectroscopy (MTS), are demonstrated for locking a fiber laser to the transition lines of metastable {sup 4}He atoms around 1083 nm. The servo-loop error signals of FMS and MTS for stabilizing laser frequency are optimized by studying the dependence of the peak-to-peak amplitude and slope on the optical power of pump and probe beams. A comparison of the stabilization performances of FMS/MTS and polarization spectroscopy (PS) is presented, which shows that MTS exhibits relatively superior performance with the least laser frequency fluctuation due to its flat-background dispersive signal, originated from the four-wave mixing process. The Allan deviation of the stabilized laser frequency is 5.4 × 10{sup ?12}@100 s with MTS for data acquired in 1000 s, which is sufficiently applicable for fields like laser cooling, optical pumping, and optical magnetometry.

  9. Sparse Signal Reconstruction via Iterative Support Detection

    E-Print Network [OSTI]

    2010-07-04T23:59:59.000Z

    Sep 29, 2009 ... and a reduced requirement on the number of measurements .... (Throughout this paper, ¯x is used to denote the true signal to reconstruct.) ...... which include sparse Gaussian signals and certain power–law decaying signals.

  10. Wide tracking range, auto ranging, low jitter phase lock loop for swept and fixed frequency systems

    DOE Patents [OSTI]

    Kerner, Thomas M. (Manorville, NY)

    2001-01-01T23:59:59.000Z

    The present invention provides a wide tracking range phase locked loop (PLL) circuit that achieves minimal jitter in a recovered clock signal, regardless of the source of the jitter (i.e. whether it is in the source or the transmission media). The present invention PLL has automatic harmonic lockout detection circuitry via a novel lock and seek control logic in electrical communication with a programmable frequency discriminator and a code balance detector. (The frequency discriminator enables preset of a frequency window of upper and lower frequency limits to derive a programmable range within which signal acquisition is effected. The discriminator works in combination with the code balance detector circuit to minimize the sensitivity of the PLL circuit to random data in the data stream). In addition, the combination of a differential loop integrator with the lock and seek control logic obviates a code preamble and guarantees signal acquisition without harmonic lockup. An adaptive cable equalizer is desirably used in combination with the present invention PLL to recover encoded transmissions containing a clock and/or data. The equalizer automatically adapts to equalize short haul cable lengths of coaxial and twisted pair cables or wires and provides superior jitter performance itself. The combination of the equalizer with the present invention PLL is desirable in that such combination permits the use of short haul wires without significant jitter.

  11. Multiple frequency method for operating electrochemical sensors

    DOE Patents [OSTI]

    Martin, Louis P. (San Ramon, CA)

    2012-05-15T23:59:59.000Z

    A multiple frequency method for the operation of a sensor to measure a parameter of interest using calibration information including the steps of exciting the sensor at a first frequency providing a first sensor response, exciting the sensor at a second frequency providing a second sensor response, using the second sensor response at the second frequency and the calibration information to produce a calculated concentration of the interfering parameters, using the first sensor response at the first frequency, the calculated concentration of the interfering parameters, and the calibration information to measure the parameter of interest.

  12. Atomic hydrogen densities in capacitively coupled very high-frequency plasmas in H{sub 2}: Effect of excitation frequency

    SciTech Connect (OSTI)

    Jolly, J.; Booth, J.-P. [Laboratoire de Physique et Technologie des Plasmas, Centre Nazionale de la Recherche Scientifique, Ecole Polytechnique, 91128 Palaiseau Cedex (France)

    2005-05-15T23:59:59.000Z

    Absolute hydrogen atom densities in pure hydrogen capacitive discharges were measured as a function of excitation frequency (13.56, 27.12, and 40.68 MHz), nominal electrical power, and gas pressure (between 0.1 and 1 Torr). Quantitative measurements were made using two-photon absorption laser-induced fluorescence (TALIF), put on an absolute scale by comparison with the TALIF signal from a known density of krypton gas, as proposed by Niemi, Schultz von Gathen, and Doebele [J. Phys. D 34, 2330 (2001)]. The H atom density increases with gas pressure and electrical power, and at a given power and pressure it increases significantly with excitation frequency. The latter can be attributed in part to increased electron density. However, time-resolved TALIF measurements in the afterglow showed that the H atom surface loss probabilities are not constant, becoming somewhat smaller when the sheath voltage is lowered, as is the case when the excitation frequency is increased, contributing to the increase in H density.

  13. Small-Signal Modeling of a Three-Phase Isolated Inverter with Both Voltage and

    E-Print Network [OSTI]

    Kimball, Jonathan W.

    Small-Signal Modeling of a Three-Phase Isolated Inverter with Both Voltage and Frequency Droop Rolla, Missouri 65409 Abstract-- In conventional power system operation, droop control methods are used. Both P- and Q-V droops have been used in synchronous machines for decades. Similar droop controllers

  14. IEEE SIGNAL PROCESSING LETTERS, VOL. 11, NO. 9, SEPTEMBER 2004 725 Speech Enhancement Using a Noncausal

    E-Print Network [OSTI]

    Cohen, Israel

    IEEE SIGNAL PROCESSING LETTERS, VOL. 11, NO. 9, SEPTEMBER 2004 725 Speech Enhancement Using--Parameter estimation, speech enhancement, time- frequency analysis. I. INTRODUCTION AN IMPORTANT parameter of numerous. However, the performance of the corresponding speech enhancement algorithm, compared with that resulting

  15. Nebraska Air Quality Regulations (Nebraska)

    Broader source: Energy.gov [DOE]

    These regulations, promulgated by the Department of Environmental Quality, contain provisions pertaining to ambient air quality standards, pollution source operating permits, emissions reporting,...

  16. Regulations For Gas Companies (Tennessee)

    Broader source: Energy.gov [DOE]

    The Regulations for Gas Companies, implemented by the Tennessee Regulatory Authority (Authority) outline the standards for metering, distribution and electricity generation for utilities using gas....

  17. Environmental Regulation, Globalization, and Innovation

    E-Print Network [OSTI]

    Ashford, Nicholas

    2009-01-01T23:59:59.000Z

    This essay explores the complex relationship between environmental regulation, innovation, and sustainable development within the context of an increasingly globalizing economy. It will be argued that industrial policy, ...

  18. Nebraska Hazardous Waste Regulations (Nebraska)

    Broader source: Energy.gov [DOE]

    These regulations, promulgated by the Department of Environmental Quality, contain provisions pertaining to hazardous waste management, waste standards, permitting requirements, and land disposal...

  19. The next restructuring: Environmental regulation

    SciTech Connect (OSTI)

    Ellerman, A.D. (Massachusetts Inst. of Tech., Cambridge, MA (United States). Center for Energy and Environmental Policy Research)

    1999-01-01T23:59:59.000Z

    From oil, to natural gas, and now electricity, the regulation of energy markets has been successively restructured to allow greater scope to market forces. The likely next domain for restructuring, environmental regulation, may seem far-fetched now, but it is no more so than the restructuring of electric utility regulation would have seemed to be twenty years ago. The grand experiment with emissions trading under the US acid rain program has set a propitious example by showing that markets in environmental goods can be constructed and that the explicit recognition of property rights in the use of the environment is compatible with effective and non-intrusive environmental regulation.

  20. Underground Injection Control Regulations (Kansas)

    Broader source: Energy.gov [DOE]

    This article prohibits injection of hazardous or radioactive wastes into or above an underground source of drinking water, establishes permit conditions and states regulations for design,...

  1. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mechanism Discovered Print The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms,...

  2. Unique Auxin Regulation Mechanism Discovered

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Wednesday, 29 August 2007 00:00 The plant hormone auxin regulates many plant growth and development processes, including shoot growth, root branching, fruit ripening, tropisms,...

  3. REGULATION POLITIQUE ET REGULATION D'USAGE DANS LE TEMPS DE TRAVAIL1

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    1 REGULATION POLITIQUE ET REGULATION D'USAGE DANS LE TEMPS DE TRAVAIL1 : par G. de Terssac, J REGULATION AND REGULATION OF USE OVER WORKING TIME In this paper we discuss « social regulations » as defined by Reynaud (1999). These regulations, in our case (working)-time regulations, are multiple. Their combination

  4. Air-flow regulation system for a coal gasifier

    DOE Patents [OSTI]

    Fasching, George E. (Morgantown, WV)

    1984-01-01T23:59:59.000Z

    An improved air-flow regulator for a fixed-bed coal gasifier is provided which allows close air-flow regulation from a compressor source even though the pressure variations are too rapid for a single primary control loop to respond. The improved system includes a primary controller to control a valve in the main (large) air supply line to regulate large slow changes in flow. A secondary controller is used to control a smaller, faster acting valve in a secondary (small) air supply line parallel to the main line valve to regulate rapid cyclic deviations in air flow. A low-pass filter with a time constant of from 20 to 50 seconds couples the output of the secondary controller to the input of the primary controller so that the primary controller only responds to slow changes in the air-flow rate, the faster, cyclic deviations in flow rate sensed and corrected by the secondary controller loop do not reach the primary controller due to the high frequency rejection provided by the filter. This control arrangement provides at least a factor of 5 improvement in air-flow regulation for a coal gasifier in which air is supplied by a reciprocating compressor through a surge tank.

  5. A Radio SETI Campaign for microsec-sec Periodic Signals

    E-Print Network [OSTI]

    Harp, G R; Astorga, Alfredo; Arbunich, Jack; Hightower, Kristin; Meitzner, Seth; Barott, W C; Nolan, Michael C; Messerschmitt, D G; Vakoch, Douglas A; Shostak, Seth; Tarter, J C

    2015-01-01T23:59:59.000Z

    We report a novel radio autocorrelation (AC) search for extraterrestrial intelligence (SETI). For selected frequencies across the terrestrial microwave window (1-10 GHz) observations were conducted at the Allen Telescope Array to identify artificial non-sinusoidal periodic signals with radio bandwidths greater than 1 kHz, which are capable of carrying substantial messages with symbol-rates from 10-10e6 Hz. Out of 243 observations, about half (101) were directed toward sources with known continuum flux greater than 1 Jy (quasars, pulsars, supernova remnants and masers), based on the hypothesis that they might harbor heretofore undiscovered natural or artificial, repetitive, phase or frequency modulation. The rest of the targets were mostly toward exoplanet stars and similarly interesting targets from the standpoint of SETI. This campaign rules out several previously untested hypotheses relating to the number of artificially modulated "natural" sources. Since we are using a phase sensitive detector, these obser...

  6. The discrete Kalman filtering approach for seismic signals deconvolution

    SciTech Connect (OSTI)

    Kurniadi, Rizal; Nurhandoko, Bagus Endar B. [Departement of Physics Intitut Teknologi Bandung, Jl. Ganesha 10 Bandung (Indonesia)

    2012-06-20T23:59:59.000Z

    Seismic signals are a convolution of reflectivity and seismic wavelet. One of the most important stages in seismic data processing is deconvolution process; the process of deconvolution is inverse filters based on Wiener filter theory. This theory is limited by certain modelling assumptions, which may not always valid. The discrete form of the Kalman filter is then used to generate an estimate of the reflectivity function. The main advantage of Kalman filtering is capability of technique to handling continually time varying models and has high resolution capabilities. In this work, we use discrete Kalman filter that it was combined with primitive deconvolution. Filtering process works on reflectivity function, hence the work flow of filtering is started with primitive deconvolution using inverse of wavelet. The seismic signals then are obtained by convoluting of filtered reflectivity function with energy waveform which is referred to as the seismic wavelet. The higher frequency of wavelet gives smaller wave length, the graphs of these results are presented.

  7. 300 Area signal cable study

    SciTech Connect (OSTI)

    Whattam, J.W.

    1994-09-15T23:59:59.000Z

    This report was prepared to discuss the alternatives available for removing the 300 Area overhead signal cable system. This system, installed in 1969, has been used for various monitoring and communication signaling needs throughout the 300 Area. Over the years this cabling system has deteriorated, has been continually reconfigured, and has been poorly documented to the point of nonreliability. The first step was to look at the systems utilizing the overhead signal cable that are still required for operation. Of the ten systems that once operated via the signal cable, only five are still required; the civil defense evacuation alarms, the public address (PA) system, the criticality alarms, the Pacific Northwest Laboratory Facilities Management Control System (FMCS), and the 384 annunciator panel. Of these five, the criticality alarms and the FMCS have been dealt with under other proposals. Therefore, this study focused on the alternatives available for the remaining three systems (evacuation alarms, PA system, and 384 panel) plus the accountability aid phones. Once the systems to be discussed were determined, then three alternatives for providing the signaling pathway were examined for each system: (1) re-wire using underground communication ducts, (2) use the Integrated Voice/Data Telecommunications System (IVDTS) already installed and operated by US West, and (3) use radio control. Each alternative was developed with an estimated cost, advantages, and disadvantages. Finally, a recommendation was provided for the best alternative for each system.

  8. Stimulation of CD107 affects LPS-induced cytokine secretion and cellular adhesion through the ERK signaling pathway in the human macrophage-like

    E-Print Network [OSTI]

    Lee, Won-Ha

    Stimulation of CD107 affects LPS-induced cytokine secretion and cellular adhesion through the ERK107 ERK Inflammation Signal transduction a b s t r a c t Lysosome-associated membrane proteins (LAMPs that extracellular signal-regulated kinase (ERK) mediates the regulatory action of CD107. These results suggest

  9. TABLE OF CONTENTS CALIFORNIA CODE OF REGULATIONS ADMINISTRATIVE REGULATIONS

    E-Print Network [OSTI]

    #12;#12;i TABLE OF CONTENTS CALIFORNIA CODE OF REGULATIONS ADMINISTRATIVE REGULATIONS Section 10............................................. Admin-7 Section 10-106 -- Locally Adopted Energy Standards Product U-Values, Solar Heat Gain Coefficient, and Air Leakage....... Admin-12 Section 10-112 -- Criteria

  10. Digital-photonic synthesis of ultra-low noise tunable signals from RF to 100 GHz

    E-Print Network [OSTI]

    Fortier, T M; Quinlan, F; Baynes, F N; Metcalf, A J; Hati, A; Ludlow, A; Hinkley, N; Shimizu, M; Ishibashi, T; Campbell, J C; Diddams, S A

    2015-01-01T23:59:59.000Z

    The demand for higher data rates and better synchronization in communication and navigation systems necessitates the development of new wideband and tunable sources with noise performance exceeding that provided by traditional oscillators and synthesizers. Precision synthesis is paramount for providing frequency references and timing in a broad range of applications including next-generation telecommunications, high precision measurement, and radar and sensing. Here we describe a digital-photonic synthesizer (DPS) based on optical frequency division that enables the generation of widely tunable signals from near DC to 100 GHz with a fractional frequency instability of 1 part in 10^15. The spectral purity of the DPS derived signals represents an improvement in close-to-carrier noise performance over the current state-of-the-art of nearly 7 orders of magnitude in the W-band (100 GHz), and up to 5 orders of magnitude in the X-band (10 GHz).

  11. Low temperature laser scanning microscopy of a superconducting radio-frequency cavity

    DOE Public Access Gateway for Energy & Science Beta (PAGES Beta)

    Ciovati, Gianluigi; Baldwin, Charles; Cheng, Guangfeng; Flood, Roger; Jordan, Kevin; Kneisel, Peter; Morrone, Michael; Nemes, George; Turlington, Larry; Wang, Haipeng; Wilson, Katherine

    2012-03-16T23:59:59.000Z

    An apparatus was developed to obtain, for the first time, 2D maps of the surface resistance of the inner surface of an operating superconducting radio-frequency niobium cavity by a low-temperature laser scanning microscopy technique. This allows identifying non-uniformities of the surface resistance with a spatial resolution of about one order of magnitude better than with earlier methods. A signal-to-noise ratio of about 10 dB was obtained with 240 mW laser power and 1 Hz modulation frequency. The various components of the apparatus, the experimental procedure and results are discussed in details in this contribution.

  12. Zero field high frequency oscillations in dual free layer spin torque oscillators

    SciTech Connect (OSTI)

    Braganca, P. M., E-mail: patrick.braganca@hgst.com; Pi, K.; Zakai, R.; Childress, J. R.; Gurney, B. A. [HGST, 3404 Yerba Buena Rd., San Jose, California 95135 (United States)] [HGST, 3404 Yerba Buena Rd., San Jose, California 95135 (United States)

    2013-12-02T23:59:59.000Z

    We observe microwave oscillations in relatively simple spin valve spin torque oscillators consisting of two in-plane free layers without spin polarizing layers. These devices exhibit two distinct modes which can reach frequencies >25?GHz in the absence of an applied magnetic field. Macrospin simulations identify these two modes as optical and acoustic modes excited by the coupling of the two layers through dipole field and spin torque effects. These results demonstrate the potential of this system as a large output power, ultrahigh frequency signal generator that can operate without magnetic field.

  13. Energy-time and frequency-time uncertainty relations: exact inequalities

    E-Print Network [OSTI]

    V. V. Dodonov; A. V. Dodonov

    2015-04-03T23:59:59.000Z

    We give a short review of known exact inequalities that can be interpreted as "energy-time" and "frequency-time" uncertainty relations. In particular we discuss a precise form of signals minimizing the physical frequency-time uncertainty product. Also, we calculate the "stationarity time" for mixed Gaussian states of a quantum harmonic oscillator, showing explicitly that pure quantum states are "more fragile" than mixed ones with the same value of the energy dispersion. The problems of quantum evolution speed limits, time operators and measurements of energy and time are briefly discussed, too.

  14. Implementation guidance for industrial-level security systems using radio frequency alarm links

    SciTech Connect (OSTI)

    Swank, R.G.

    1996-07-12T23:59:59.000Z

    Spread spectrum (SS) RF transmission technologies have properties that make the transmitted signal difficult to intercept, interpret, and jam. The digital code used in the modulation process results in a signal that has high reception reliability and supports multiple use of frequency bands and selective addressing. These attributes and the relatively low installation cost of RF systems make SSRF technologies candidate for communications links in security systems used for industrial sites, remote locations, and where trenching or other disturbances of soil or structures may not be desirable or may be costly. This guide provides a description of such a system and presents implementation methods that may be of engineering benefit.

  15. Erfassen physikalischer Signale 73 III. Erfassen physikalischer Signale

    E-Print Network [OSTI]

    elektrische Spannung umgesetzt, die dann weiter- verarbeitet bzw. aufbereitet wird. Zur Auswertung muß dieses elektrische Signal dann aufgenommen werden, um dann gespeichert, weiterverarbei- tet oder z. B. graphisch durch die neuronale Verschaltung der Netz- haut bewerkstelligt werden, während die Einheit aus Sehnerv

  16. CMD-3 Liquid Xenon Calorimeter's signals processing

    E-Print Network [OSTI]

    CMD-3 Liquid Xenon Calorimeter's signals processing for timing measurements. Leonid Epshtein Budker connected to constitute 264 «towers»; signal of each tower is processed by electronic channel. Liquid Xenon functional channel scheme and signal's shapes in the typical point. Digital Signal Processing ADCCSALXe

  17. Signal Subspace Methods for Speech Enhancement

    E-Print Network [OSTI]

    Signal Subspace Methods for Speech Enhancement Ph.D. Thesis Peter S. K. Hansen LYNGBY 1997 IMM Lyngby -- Denmark 1997­09­30 pskh Signal Subspace Methods for Speech Enhancement Ph.D. Thesis Peter S. K is Signal Subspace Methods for Speech Enhancement where techniques from the areas of signal processing

  18. Advanced Workshop in Regulation and

    E-Print Network [OSTI]

    Lin, Xiaodong

    Advanced Workshop in Regulation and Competition 2011-2012 Conflicting Technological and Competitive Forces in Regulated Industries January 13, 2012 Smart Grid and Rates Location: Rutgers Business School 1:40pm "Smart Grid in Maryland" Kurt Strunk, NERA Economic Consulting, 1:40pm-2:05pm "Gas Pipeline Rates

  19. Multiple-frequency acoustic wave devices for chemical sensing and materials characterization in both gas and liquid phase

    DOE Patents [OSTI]

    Martin, S.J.; Ricco, A.J.

    1993-08-10T23:59:59.000Z

    A chemical or intrinsic physical property sensor is described comprising: (a) a substrate; (b) an interaction region of said substrate where the presence of a chemical or physical stimulus causes a detectable change in the velocity and/or an attenuation of an acoustic wave traversing said region; and (c) a plurality of paired input and output interdigitated electrodes patterned on the surface of said substrate where each of said paired electrodes has a distinct periodicity, where each of said paired electrodes is comprised of an input and an output electrode; (d) an input signal generation means for transmitting an input signal having a distinct frequency to a specified input interdigitated electrode of said plurality so that each input electrode receives a unique input signal, whereby said electrode responds to said input signal by generating an acoustic wave of a specified frequency, thus, said plurality responds by generating a plurality of acoustic waves of different frequencies; (e) an output signal receiving means for determining an acoustic wave velocity and an amplitude of said acoustic waves at several frequencies after said waves transverses said interaction region and comparing these values to an input acoustic wave velocity and an input acoustic wave amplitude to produce values for perturbations in acoustic wave velocities and for acoustic wave attenuation as a function of frequency, where said output receiving means is individually coupled to each of said output interdigitated electrode; (f) a computer means for analyzing a data stream comprising information from said output receiving means and from said input signal generation means to differentiate a specified response due to a perturbation from a subsequent specified response due to a subsequent perturbation to determine the chemical or intrinsic physical properties desired.

  20. Octave Spanning Frequency Comb on a Chip

    E-Print Network [OSTI]

    Del'Haye, P; Gavartin, E; Holzwarth, R; Kippenberg, T J

    2009-01-01T23:59:59.000Z

    Optical frequency combs have revolutionized the field of frequency metrology within the last decade and have become enabling tools for atomic clocks, gas sensing and astrophysical spectrometer calibration. The rapidly increasing number of applications has heightened interest in more compact comb generators. Optical microresonator based comb generators bear promise in this regard. Critical to their future use as 'frequency markers', is however the absolute frequency stabilization of the optical comb spectrum. A powerful technique for this stabilization is self-referencing, which requires a spectrum that spans a full octave, i.e. a factor of two in frequency. In the case of mode locked lasers, overcoming the limited bandwidth has become possible only with the advent of photonic crystal fibres for supercontinuum generation. Here, we report for the first time the generation of an octave-spanning frequency comb directly from a toroidal microresonator on a silicon chip. The comb spectrum covers the wavelength range...

  1. Frequency Control Performance Measurement and Requirements

    SciTech Connect (OSTI)

    Illian, Howard F.

    2010-12-20T23:59:59.000Z

    Frequency control is an essential requirement of reliable electric power system operations. Determination of frequency control depends on frequency measurement and the practices based on these measurements that dictate acceptable frequency management. This report chronicles the evolution of these measurements and practices. As technology progresses from analog to digital for calculation, communication, and control, the technical basis for frequency control measurement and practices to determine acceptable performance continues to improve. Before the introduction of digital computing, practices were determined largely by prior experience. In anticipation of mandatory reliability rules, practices evolved from a focus primarily on commercial and equity issues to an increased focus on reliability. This evolution is expected to continue and place increased requirements for more precise measurements and a stronger scientific basis for future frequency management practices in support of reliability.

  2. Optically isolated signal coupler with linear response

    DOE Patents [OSTI]

    Kronberg, James W. (Aiken, SC)

    1994-01-01T23:59:59.000Z

    An optocoupler for isolating electrical signals that translates an electrical input signal linearly to an electrical output signal. The optocoupler comprises a light emitter, a light receiver, and a light transmitting medium. The light emitter, preferably a blue, silicon carbide LED, is of the type that provides linear, electro-optical conversion of electrical signals within a narrow wavelength range. Correspondingly, the light receiver, which converts light signals to electrical signals and is preferably a cadmium sulfide photoconductor, is linearly responsive to light signals within substantially the same wavelength range as the blue LED.

  3. Frequency modulation drive for a piezoelectric motor

    DOE Patents [OSTI]

    Mittas, Anthony (Albuquerque, NM)

    2001-01-01T23:59:59.000Z

    A piezoelectric motor has peak performance at a specific frequency f.sub.1 that may vary over a range of frequencies. A drive system is disclosed for operating such a motor at peak performance without feedback. The drive system consists of the motor and an ac source connected to power the motor, the ac source repeatedly generating a frequency over a range from f.sub.1 -.DELTA.x to f.sub.1 +.DELTA.y.

  4. Competitive niche: Way of population regulation

    E-Print Network [OSTI]

    Meszéna, Géza

    1 / 27 Competitive niche: Way of population regulation G´eza Mesz´ena1, Andr´as Szil´agyi1, Kalle of coexistence Theory Regulating loop Results Examples Spatial segregation Functional & spatial segregation Regulating loop y Results Examples Conclusions 7 / 27 #12;Regulating loop Introduction Theory y Regulating

  5. Low-frequency quantitative ultrasound imaging of cell death in vivo

    SciTech Connect (OSTI)

    Sadeghi-Naini, Ali; Falou, Omar; Czarnota, Gregory J. [Imaging Research – Physical Science, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5 (Canada) [Imaging Research – Physical Science, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5 (Canada); Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5 (Canada); Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M4N 3M5 (Canada); Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M4N 3M5 (Canada); Papanicolau, Naum; Tadayyon, Hadi [Imaging Research – Physical Science, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M4N 3M5 (Canada)] [Imaging Research – Physical Science, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada and Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M4N 3M5 (Canada); Lee, Justin [Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada and Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M4N 3M5 (Canada)] [Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada and Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario M4N 3M5 (Canada); Zubovits, Judit [Department of Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5 (Canada)] [Department of Pathology, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5 (Canada); Sadeghian, Alireza [Department of Computer Science, Ryerson University, Toronto, Ontario M5B 2K3 (Canada)] [Department of Computer Science, Ryerson University, Toronto, Ontario M5B 2K3 (Canada); Karshafian, Raffi [Department of Physics, Ryerson University, Toronto, Ontario M5B 2K3 (Canada)] [Department of Physics, Ryerson University, Toronto, Ontario M5B 2K3 (Canada); Al-Mahrouki, Azza; Giles, Anoja [Imaging Research – Physical Science, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada and Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5 (Canada)] [Imaging Research – Physical Science, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5, Canada and Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N 3M5 (Canada); Kolios, Michael C. [Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M4N 3M5, Canada and Department of Physics, Ryerson University, Toronto, Ontario M5B 2K3 (Canada)] [Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Ontario M4N 3M5, Canada and Department of Physics, Ryerson University, Toronto, Ontario M5B 2K3 (Canada)

    2013-08-15T23:59:59.000Z

    Purpose: Currently, no clinical imaging modality is used routinely to assess tumor response to cancer therapies within hours to days of the delivery of treatment. Here, the authors demonstrate the efficacy of ultrasound at a clinically relevant frequency to quantitatively detect changes in tumors in response to cancer therapies using preclinical mouse models.Methods: Conventional low-frequency and corresponding high-frequency ultrasound (ranging from 4 to 28 MHz) were used along with quantitative spectroscopic and signal envelope statistical analyses on data obtained from xenograft tumors treated with chemotherapy, x-ray radiation, as well as a novel vascular targeting microbubble therapy.Results: Ultrasound-based spectroscopic biomarkers indicated significant changes in cell-death associated parameters in responsive tumors. Specifically changes in the midband fit, spectral slope, and 0-MHz intercept biomarkers were investigated for different types of treatment and demonstrated cell-death related changes. The midband fit and 0-MHz intercept biomarker derived from low-frequency data demonstrated increases ranging approximately from 0 to 6 dBr and 0 to 8 dBr, respectively, depending on treatments administrated. These data paralleled results observed for high-frequency ultrasound data. Statistical analysis of ultrasound signal envelope was performed as an alternative method to obtain histogram-based biomarkers and provided confirmatory results. Histological analysis of tumor specimens indicated up to 61% cell death present in the tumors depending on treatments administered, consistent with quantitative ultrasound findings indicating cell death. Ultrasound-based spectroscopic biomarkers demonstrated a good correlation with histological morphological findings indicative of cell death (r{sup 2}= 0.71, 0.82; p < 0.001).Conclusions: In summary, the results provide preclinical evidence, for the first time, that quantitative ultrasound used at a clinically relevant frequency, in addition to high-frequency ultrasound, can detect tissue changes associated with cell death in vivo in response to cancer treatments.

  6. Hazle Spindle, LLC Beacon Power 20 MW Flywheel Frequency Regulation Plant

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742Energy ChinaofSchaefer To:Department of Energy Completing theWhiz! |Nearly six weeks Hazle

  7. Fact Sheet: Beacon Power 20 MW Flywheel Frequency Regulation Plant (August

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic Plan| Department of.pdf6-OPAMDepartment6 FY 2007FYFacilityDepartment of|2013) |

  8. Fact Sheet: Beacon Power 20 MW Flywheel Frequency Regulation Plant (August

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels DataDepartment of Energy Your Density Isn't YourTransport in RepresentativeDepartment ofDepartmentLast TenPrice of|SNL OnSilicon

  9. Frequency Instability Problems in North American Interconnections

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    cycle CFC Constant frequency control CPS Control Performance Standards DC Direct Current EI Eastern Interconnection EIA Energy Information Agency ERCOT Electric Reliability...

  10. Ris-R-1500(EN) Control design for a pitch-regulated, vari-

    E-Print Network [OSTI]

    Risø-R-1500(EN) Control design for a pitch-regulated, vari- able speed wind turbine Morten H speed wind tur- bine Department: Wind Energy Department Risø-R-1500(EN) January 2005 ISSN 0106-2840 ISBN wind speed, which can be almost removed by changing the parameters of the frequency converter

  11. TEACHING AND EXAMINATION REGULATIONS (see Article 7.13 of the Higher Education and

    E-Print Network [OSTI]

    Act) 3TU MASTER'S DEGREE PROGRAMME Sustainable Energy Technology DELFT UNIVERSITY OF TECHNOLOGY UNIVERSITY OF TWENTE EINDHOVEN UNIVERSITY OF TECHNOLOGY 3TU Teaching and Examination Regulations SET 2013 Article 16 - Free programme choice 10 Section 5 - Degree audit 10 Article 17 - The times and frequency

  12. Absolute frequency measurements of 85Rb nF7/2 Rydberg states using purely optical detection

    E-Print Network [OSTI]

    L. A. M. Johnson; H. O. Majeed; B. Sanguinetti; Th. Becker; B. T. H. Varcoe

    2010-02-16T23:59:59.000Z

    A three-step laser excitation scheme is used to make absolute frequency measurements of highly excited nF7/2 Rydberg states in 85Rb for principal quantum numbers n=33-100. This work demonstrates the first absolute frequency measurements of rubidium Rydberg levels using a purely optical detection scheme. The Rydberg states are excited in a heated Rb vapour cell and Doppler free signals are detected via purely optical means. All of the frequency measurements are made using a wavemeter which is calibrated against a GPS disciplined self-referenced optical frequency comb. We find that the measured levels have a very high frequency stability, and are especially robust to electric fields. The apparatus has allowed measurements of the states to an accuracy of 8.0MHz. The new measurements are analysed by extracting the modified Rydberg-Ritz series parameters.

  13. ATP-dependent regulation of nuclear Ca2 levels in plant cells

    E-Print Network [OSTI]

    Shaw, Peter

    ATP-dependent regulation of nuclear Ca2 levels in plant cells Tom D. Bunney, Peter J. Shaw, Peter A in [Ca2+ ] occurs in the nuclear periphery. The occurrence of ATP-dependent Ca2+ uptake in plant nuclei rights reserved. Key words: Nucleus; Plant; Ca2 uptake; Signal transduction; Imaging; Nuclear pore

  14. Redox Regulation of the Nutrient-sensitive Raptor-mTOR Pathway and Complex*

    E-Print Network [OSTI]

    Sabatini, David M.

    Redox Regulation of the Nutrient-sensitive Raptor-mTOR Pathway and Complex* Received, Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142 The raptor-mTOR protein complex is a key component of a nutrient-sensitive signaling pathway

  15. NOTICE OF PROPOSED REGULATION AMENDMENT Date: August 18, 2005

    E-Print Network [OSTI]

    Wu, Shin-Tson

    , Deputy Director of Florida Solar Energy Center COMMENTS CONCERNING THE PROPOSED REGULATION AMENDMENTNOTICE OF PROPOSED REGULATION AMENDMENT Date: August 18, 2005 REGULATION TITLE: REGULATION NO OF REGULATION AMENDMENT: This regulation is revised significantly to reflect updated naming conventions

  16. Length sensing and control of a Michelson interferometer with Power Recycling and Twin Signal Recycling cavities

    E-Print Network [OSTI]

    Christian Gräf; André Thüring; Henning Vahlbruch; Karsten Danzmann; Roman Schnabel

    2012-11-29T23:59:59.000Z

    The techniques of power recycling and signal recycling have proven as key concepts to increase the sensitivity of large-scale gravitational wave detectors by independent resonant enhancement of light power and signal sidebands within the interferometer. Developing the latter concept further, twin signal recycling was proposed as an alternative to conventional detuned signal recycling. Twin signal recycling features the narrow-band sensitivity gain of conventional detuned signal recycling but furthermore facilitates the injection of squeezed states of light, increases the detector sensitivity over a wide frequency band and requires a less complex detection scheme for optimal signal readout. These benefits come at the expense of an additional recycling mirror, thus increasing the number of degrees of freedom in the interferometer which need to be controlled. In this article we describe the development of a length sensing and control scheme and its successful application to a tabletop-scale power recycled Michelson interferometer with twin signal recycling. We were able to lock the interferometer in all relevant longitudinal degrees of freedom, enabling the long-term stable operation of the experiment. We thus laid the foundation for further investigations of this interferometer topology to evaluate its viability for the application in gravitational wave detectors.

  17. Ross Ice Shelf in situ radio-frequency ice attenuation

    E-Print Network [OSTI]

    Taylor Barrella; Steven Barwick; David Saltzberg

    2012-05-01T23:59:59.000Z

    We have measured the in situ average electric field attenuation length for radio-frequency signals broadcast vertically through the Ross Ice Shelf. We chose a location, Moore Embayment, south of Minna Bluff, known for its high reflectivity at the ice-sea interface. We confirmed specular reflection and used the return pulses to measure the average attenuation length from 75-1250 MHz over the round-trip distance of 1155 m. We find the average electric field attenuation length to vary from 500 m at 75 MHz to 300 m at 1250 MHz, with an experimental uncertainty of 55 to 15 m. We discuss the implications for neutrino telescopes that use the radio technique and include the Ross Ice Shelf as part of their sensitive volume.

  18. Agile high resolution arbitrary waveform generator with jitterless frequency stepping

    DOE Patents [OSTI]

    Reilly, Peter T.; Koizumi, Hideya

    2010-05-11T23:59:59.000Z

    Jitterless transition of the programmable clock waveform is generated employing a set of two coupled direct digital synthesis (DDS) circuits. The first phase accumulator in the first DDS circuit runs at least one cycle of a common reference clock for the DDS circuits ahead of the second phase accumulator in the second DDS circuit. As a phase transition through the beginning of a phase cycle is detected from the first phase accumulator, a first phase offset word and a second phase offset word for the first and second phase accumulators are calculated and loaded into the first and second DDS circuits. The programmable clock waveform is employed as a clock input for the RAM address controller. A well defined jitterless transition in frequency of the arbitrary waveform is provided which coincides with the beginning of the phase cycle of the DDS output signal from the second DDS circuit.

  19. Method for imaging with low frequency electromagnetic fields

    DOE Patents [OSTI]

    Lee, Ki H. (Lafayette, CA); Xie, Gan Q. (Berkeley, CA)

    1994-01-01T23:59:59.000Z

    A method for imaging with low frequency electromagnetic fields, and for interpreting the electromagnetic data using ray tomography, in order to determine the earth conductivity with high accuracy and resolution. The imaging method includes the steps of placing one or more transmitters, at various positions in a plurality of transmitter holes, and placing a plurality of receivers in a plurality of receiver holes. The transmitters generate electromagnetic signals which diffuse through a medium, such as earth, toward the receivers. The measured diffusion field data H is then transformed into wavefield data U. The traveltimes corresponding to the wavefield data U, are then obtained, by charting the wavefield data U, using a different regularization parameter .alpha. for each transform. The desired property of the medium, such as conductivity, is then derived from the velocity, which in turn is constructed from the wavefield data U using ray tomography.

  20. Time-Delay Interferometry with optical frequency comb

    E-Print Network [OSTI]

    Tinto, Massimo

    2015-01-01T23:59:59.000Z

    Heterodyne laser phase measurements in a space-based gravitational wave interferometer are degraded by the phase fluctuations of the onboard clocks, resulting in unacceptable sensitivity performance levels of the interferometric data. In order to calibrate out the clock phase noises it has been previously suggested that additional inter-spacecraft phase measurements must be performed by modulating the laser beams. This technique, however, considerably increases system complexity and probability of subsystem failure. With the advent of self-referenced optical frequency combs, it is possible to generate the heterodyne microwave signal that is coherently referenced to the onboard laser. We show in this case that the microwave noise can be cancelled directly by applying modified second-generation Time-Delay Interferometric combinations to the heterodyne phase measurements. This approach avoids use of modulated laser beams as well as the need of additional ultra-stable oscillator clocks.

  1. Time-Delay Interferometry with optical frequency comb

    E-Print Network [OSTI]

    Massimo Tinto; Nan Yu

    2015-02-23T23:59:59.000Z

    Heterodyne laser phase measurements in a space-based gravitational wave interferometer are degraded by the phase fluctuations of the onboard clocks, resulting in unacceptable sensitivity performance levels of the interferometric data. In order to calibrate out the clock phase noises it has been previously suggested that additional inter-spacecraft phase measurements must be performed by modulating the laser beams. This technique, however, considerably increases system complexity and probability of subsystem failure. With the advent of self-referenced optical frequency combs, it is possible to generate the heterodyne microwave signal that is coherently referenced to the onboard laser. We show in this case that the microwave noise can be cancelled directly by applying modified second-generation Time-Delay Interferometric combinations to the heterodyne phase measurements. This approach avoids use of modulated laser beams as well as the need of additional ultra-stable oscillator clocks.

  2. Method for imaging with low frequency electromagnetic fields

    DOE Patents [OSTI]

    Lee, K.H.; Xie, G.Q.

    1994-12-13T23:59:59.000Z

    A method is described for imaging with low frequency electromagnetic fields, and for interpreting the electromagnetic data using ray tomography, in order to determine the earth conductivity with high accuracy and resolution. The imaging method includes the steps of placing one or more transmitters, at various positions in a plurality of transmitter holes, and placing a plurality of receivers in a plurality of receiver holes. The transmitters generate electromagnetic signals which diffuse through a medium, such as earth, toward the receivers. The measured diffusion field data H is then transformed into wavefield data U. The travel times corresponding to the wavefield data U, are then obtained, by charting the wavefield data U, using a different regularization parameter [alpha] for each transform. The desired property of the medium, such as conductivity, is then derived from the velocity, which in turn is constructed from the wavefield data U using ray tomography. 13 figures.

  3. Sudden structural change at ati air/binary liquid interface: Sum frequency study of the air/acetonitrile-water interface

    E-Print Network [OSTI]

    Eisenthal, Kenneth B.

    Sudden structural change at ati air/binary liquid interface: Sum frequency study of the air/acetonitrile change in an air/acetonitrile-water interface as the solution composition varies; the abruptness of which and in the polarization of the signal from the acetonitrile molecules in the interface observed using infrared + visible

  4. Multidrug resistant protein-three gene regulation

    E-Print Network [OSTI]

    Mahaffey, Christopher M.

    2010-01-01T23:59:59.000Z

    H. R. ;Mulcahy, R. T. Up-regulation of the human gamma-H. R. ; Mulcahy, R. T. Regulation of gamma- glutamylcysteine19] Gerk, P. M. ; Vore, M. Regulation of expression of the

  5. MANEUVER REGULATION, TRANSVERSE FEEDBACK LINEARIZATION, AND ZERO

    E-Print Network [OSTI]

    Maggiore, Manfredi

    MANEUVER REGULATION, TRANSVERSE FEEDBACK LINEARIZATION, AND ZERO DYNAMICS Chris Nielsen,1 Manfredi focus is on output maneuver regulation where stabilizing transverse dynamics is a key requirement. Keywords: Maneuver regulation, path following, feedback linearization, zero dynamics, non-square systems

  6. Army Regulation 2550 Information Management: Records

    E-Print Network [OSTI]

    US Army Corps of Engineers

    Army Regulation 25­50 Information Management: Records Management Preparing and Managing Information Management: Records Management Preparing and Managing Correspondence *Army Regulation 25. This regulation on the prepa- ration and management of Army corre- spondence has been revised. This revision

  7. Post regulation circuit with energy storage

    DOE Patents [OSTI]

    Ball, Don G. (Livermore, CA); Birx, Daniel L. (Oakley, CA); Cook, Edward G. (Livermore, CA)

    1992-01-01T23:59:59.000Z

    A charge regulation circuit provides regulation of an unregulated voltage supply and provides energy storage. The charge regulation circuit according to the present invention provides energy storage without unnecessary dissipation of energy through a resistor as in prior art approaches.

  8. Regulating competitive markets: How to proceed?

    SciTech Connect (OSTI)

    Santa, D.F. Jr.

    1995-12-31T23:59:59.000Z

    This paper describes the regulation of electricity and natural gas market. The prerequisites for market-based rates, regulating potentially competitive markets, regulating services where market power exists, and electronic communications and trading systems are discussed.

  9. Local readout enhancement for detuned signal-recycling interferometers

    E-Print Network [OSTI]

    Henning Rehbein; Helge Mueller-Ebhardt; Kentaro Somiya; Chao Li; Roman Schnabel; Karsten Danzmann; Yanbei Chen

    2007-08-22T23:59:59.000Z

    Motivated by the optical-bar scheme of Braginsky, Gorodetsky and Khalili, we propose to add to a high power detuned signal-recycling interferometer a local readout scheme which measures the motion of the arm-cavity front mirror. At low frequencies this mirror moves together with the arm-cavity end mirror, under the influence of gravitational waves. This scheme improves the low-frequency quantum-noise-limited sensitivity of optical-spring interferometers significantly and can be considered as a incorporation of the optical-bar scheme into currently planned second-generation interferometers. On the other hand it can be regarded as an extension of the optical bar scheme. Taking compact-binary inspiral signals as an example, we illustrate how this scheme can be used to improve the sensitivity of the planned Advanced LIGO interferometer, in various scenarios, using a realistic classical-noise budget. We also discuss how this scheme can be implemented in Advanced LIGO with relative ease.

  10. Measurements of ionospheric effects on wideband signals at VHF

    SciTech Connect (OSTI)

    Fitzgerald, T.J.

    1998-08-17T23:59:59.000Z

    Radars operating at very high frequency (VHF) have enhanced foliage and ground penetration compared to radars operated at higher frequencies. For example, VHF systems operated from airplanes have been used as synthetic aperture radars (SAR); a satellite-borne VHF SAR would have considerable utility. In order to operate with high resolution it would have to use both a large relative bandwidth and a large aperture. A satellite-borne radar would likely have to operate at altitudes above the maximum density of the ionosphere; the presence of the ionosphere in the propagation path of the radar will cause a deterioration of the performance because of dispersion over the bandwidth. The author presents measurements of the effects of the ionosphere on radar signals propagated from a source on the surface of the Earth and received by instruments on the FORTE satellite at altitudes of 800 km. The author employs signals with a 90 MHz bandwidth centered at 240 MHz with a continuous digital recording period of 0.6 s.

  11. Gravitational Bending of Light with Frequency Shifts

    E-Print Network [OSTI]

    P. D. Morley

    1993-11-15T23:59:59.000Z

    Non-static gravitational fields generally introduce frequency shifts when bending light. In this paper, I discuss the frequency shifts induced in the bending of light by moving masses. As examples, I treat the recently discovered high-velocity pulsar PSR 2224+65 and a typical Einstein ring.

  12. Distributed Online Frequency Assignment in Cellular Networks ?

    E-Print Network [OSTI]

    Devoto, Stephen H.

    Distributed Online Frequency Assignment in Cellular Networks ? (Extended Abstract) Jeannette a general framework for studying distributed online frequency assignment in cellular networks. The problem at the corresponding network cell. In this setting, we present several distributed online algorithms for this problem

  13. Nucleotide Frequency Variation Across Human Genes

    E-Print Network [OSTI]

    Majewski, Jacek

    Nucleotide Frequency Variation Across Human Genes Elizabeth Louie, Jurg Ott, and Jacek Majewski1 The Rockefeller University, New York, New York 10021, USA The frequencies of individual nucleotides exhibit significant fluctuations across eukaryotic genes. In this paper, we investigate nucleotide variation across

  14. A Dual Tone Multiple Frequency receiver using a multiplexed OTA-C filter frequency detection architecture

    E-Print Network [OSTI]

    Garcia, Gerald William

    1988-01-01T23:59:59.000Z

    A DUAL TONE MULTIPLE FREQUENCY RECEIVER USING A MULTIPLEXED OTA-C FILTER FREQUENCY DETECTION ARCHITECTURE A Thesis by GERALD WILLIAM GARCIA Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement... for the degree of MASTER OF SCIENCE August 1988 Major Subject: Electrical Engineering A DUAL TONE MULTIPLE FREQUENCY RECEIVER USING A MULTIPLEXED OTA-C FILTER FREQUENCY DETECTION ARCHITECTURE A Thesis by GERALD WILLIAM GARCIA Approved as to style...

  15. Design of dual frequency interferometric SAR

    SciTech Connect (OSTI)

    Kim, Y.; Edelstein, W.; Caro, E. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California 91109 (United States)

    1996-03-01T23:59:59.000Z

    Using a spaceborne interferometric SAR, it is possible to produce a high resolution global topographic map with a height accuracy of several meters. However, frequency selection of the interferometric SAR is rather complicated due to interferometric phenomenology and atmospheric effects. In this paper, we propose a dual frequency interferometric SAR to achieve better understanding of interferometric height (especially for penetrable medium) and corresponding calibration and to remove the atmospheric effects. The selected frequencies are L- and Ku- bands. We also present a radar design and show that a light weight and efficient SAR can be designed using new technologies and dual frequency advantages even with two frequency radars in a single spacecraft. {copyright} {ital 1996 American Institute of Physics.}

  16. A signal oriented stream processing system for pipeline monitoring

    E-Print Network [OSTI]

    Tokmouline, Timur

    2006-01-01T23:59:59.000Z

    In this thesis, we develop SignalDB, a framework for composing signal processing applications from primitive stream and signal processing operators. SignalDB allows the user to focus on the signal processing task and avoid ...

  17. The Nuclear Installations (Dangerous Occurrences) Regulations 1965 

    E-Print Network [OSTI]

    Lee, Fred; Ross, William

    1965-01-01T23:59:59.000Z

    STATUTORY INSTRUMENTS 1965 No. 1824 ATOMIC ENERGY AND RADIOACTIVE SUBSTANCES LICENSING AND REGULATION OF SITES The Nuclear Installations (Dangerous Occurrences) Regulations 1965...

  18. Aquifer Protection Area Land Use Regulations (Connecticut)

    Broader source: Energy.gov [DOE]

    These regulations describe allowable activities within aquifer protection areas, the procedure by which such areas are delineated, and relevant permit requirements. The regulations also describe...

  19. International Electricity Regulation | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    Regulation International Electricity Regulation U.S. trade in electric energy with Canada and Mexico is rising, bringing economic and reliability benefits to the United States and...

  20. Vermont Hazardous Waste Management Regulations (Vermont)

    Broader source: Energy.gov [DOE]

    These regulations are intended to protect public health and the environment by comprehensively regulating the generation, storage, collection, transport, treatment, disposal, use, reuse, and...

  1. Searchable Electronic Department of Energy Acquisition Regulation...

    Office of Environmental Management (EM)

    Searchable Electronic Department of Energy Acquisition Regulation Searchable Electronic Department of Energy Acquisition Regulation Updated July 2, 2013. The EDEAR is current...

  2. Virginia Electric Utility Regulation Act (Virginia)

    Broader source: Energy.gov [DOE]

    The Virginia Electric Utility Regulation Act constitutes the main legislation in Virginia that pertains to the regulation of the state's electric utilities. The Act directs the State Corporation...

  3. Sum-Frequency Generation from Chiral Media and Interfaces

    SciTech Connect (OSTI)

    Ji, Na

    2006-02-13T23:59:59.000Z

    Sum frequency generation (SFG), a second-order nonlinear optical process, is electric-dipole forbidden in systems with inversion symmetry. As a result, it has been used to study chiral media and interfaces, systems intrinsically lacking inversion symmetry. This thesis describes recent progresses in the applications of and new insights into SFG from chiral media and interfaces. SFG from solutions of chiral amino acids is investigated, and a theoretical model explaining the origin and the strength of the chiral signal in electronic-resonance SFG spectroscopy is discussed. An interference scheme that allows us to distinguish enantiomers by measuring both the magnitude and the phase of the chiral SFG response is described, as well as a chiral SFG microscope producing chirality-sensitive images with sub-micron resolution. Exploiting atomic and molecular parity nonconservation, the SFG process is also used to solve the Ozma problems. Sum frequency vibrational spectroscopy is used to obtain the adsorption behavior of leucine molecules at air-water interfaces. With poly(tetrafluoroethylene) as a model system, we extend the application of this surface-sensitive vibrational spectroscopy to fluorine-containing polymers.

  4. The frequency of planets in multiple systems

    E-Print Network [OSTI]

    M. Bonavita; S. Desidera

    2007-03-29T23:59:59.000Z

    The frequency of planets in binaries is an important issue in the field of extrasolar planet studies, because of its relevance in estimating of the global planet population of our Galaxy and the clues it can give to our understanding of planet formation and evolution. However, only preliminary estimates are available in the literature. We analyze and compare the frequency of planets in multiple systems to the frequency of planets orbiting single stars. We also try to highlight possible connections between the frequency of planets and the orbital parameters of the binaries (such as the periastron and mass ratio.) A literature search was performed for binaries and multiple systems among the stars of the sample with uniform planet detectability defined by Fischer & Valenti (2005), and 202 of the 850 stars of the sample turned out to be binaries, allowing a statistical comparison of the frequency of planets in binaries and single stars and a study of the run of the planet frequency as a function of the binary separation. We found that the global frequency of planets in the binaries of the sample is not statistically different from that of planets in single stars. Even conservatively taking the probable incompleteness of binary detection in our sample into account, we estimate that the frequency of planets in binaries can be no more than a factor of three lower than that of planets in single stars. There is no significant dependence of planet frequency on the binary separation, except for a lower value of frequency for close binaries. However, this is probably not as low as required to explain the presence of planets in close binaries only as the result of modifications of the binary orbit after the planet formation.

  5. E4.18 Radio Frequency Electronics Copyright 2006 Dr Stepan Lucyszyn Frequency Spectrum

    E-Print Network [OSTI]

    Papavassiliou, Christos

    Applications Phased-array radar Electronic warfare (e.g. Electronic Surveillance Measures, ECM, ECCM, decoysE4.18 Radio Frequency Electronics Copyright © 2006 Dr Stepan Lucyszyn Frequency Spectrum and Applications #12;E4.18 Radio Frequency Electronics Copyright © 2006 Dr Stepan Lucyszyn #12;E4.18 Radio

  6. Nuclear sensor signal processing circuit

    DOE Patents [OSTI]

    Kallenbach, Gene A. (Bosque Farms, NM); Noda, Frank T. (Albuquerque, NM); Mitchell, Dean J. (Tijeras, NM); Etzkin, Joshua L. (Albuquerque, NM)

    2007-02-20T23:59:59.000Z

    An apparatus and method are disclosed for a compact and temperature-insensitive nuclear sensor that can be calibrated with a non-hazardous radioactive sample. The nuclear sensor includes a gamma ray sensor that generates tail pulses from radioactive samples. An analog conditioning circuit conditions the tail-pulse signals from the gamma ray sensor, and a tail-pulse simulator circuit generates a plurality of simulated tail-pulse signals. A computer system processes the tail pulses from the gamma ray sensor and the simulated tail pulses from the tail-pulse simulator circuit. The nuclear sensor is calibrated under the control of the computer. The offset is adjusted using the simulated tail pulses. Since the offset is set to zero or near zero, the sensor gain can be adjusted with a non-hazardous radioactive source such as, for example, naturally occurring radiation and potassium chloride.

  7. State Water Permit Regulation (Arkansas)

    Broader source: Energy.gov [DOE]

    It is the purpose of this regulation to adopt standards applicable to the storage, discharge, or disposal of any waste which, if unregulated, will cause pollution of waters of the state or result...

  8. DISPLAY SCREEN EQUIPMENT REGULATIONS 1992

    E-Print Network [OSTI]

    , charts or computer-generated graphics are included. Screens whose main use is to show television or film the standards required by the Regulations. 4 RISKS FROM USING DISPLAY SCREENS The principal risk associated when

  9. Water Quality Regulations (Rhode Island)

    Broader source: Energy.gov [DOE]

    The purpose of these regulations is to establish water quality standards for the state's surface waters. These standards are intended to restore, preserve and enhance the physical, chemical and...

  10. Kansas Air Quality Regulations (Kansas)

    Broader source: Energy.gov [DOE]

    All new air contaminant emission sources or alterations to emission sources that are required to be reported shall be in compliance with all applicable emission control regulations at the time that...

  11. Private Regulation of Consumer Arbitration

    E-Print Network [OSTI]

    Drahozal, Christopher R.; Zyontz, Samantha

    2012-01-01T23:59:59.000Z

    Arbitration providers, such as the American Arbitration Association (“AAA”) and JAMS, have promulgated due process protocols to regulate the fairness of consumer and employment arbitration agreements. A common criticism of these due process...

  12. Ground Water Management Regulations (Louisiana)

    Broader source: Energy.gov [DOE]

    The rules and regulations apply to the management of the state's ground water resources. In addition, the Commissioner of Conservation has recommended that oil and gas operators with an interest...

  13. Modellering og regulering af affaldsforbrnding

    E-Print Network [OSTI]

    deals with the regulation of a Danish waste incineration plant. It is tested if the flame front can on the Waste Incineration Plant, Haderslev Kraftvar- meværk in Denmark. Concurrently the position of the flame

  14. Portable Microwave Frequency Dissemination in Free Space and Implications on Ground-Satellite Synchronization

    E-Print Network [OSTI]

    Wang, Bo; Bai, Yu; Yuan, Yibo; Gao, Chao; Wang, Lijun

    2015-01-01T23:59:59.000Z

    Frequency dissemination and synchronization in free space plays an important role in global navigation satellite system (GNSS), radio astronomy and synthetic aperture radar (SAR). In this paper, we demonstrate a portable radio frequency (RF) dissemination scheme via free space using microwave antennas. The setup has a good environment adaptability and high dissemination stability. The frequency signal is disseminated at different distances ranging from 10 to 640 m with a fixed 10 Hz locking bandwidth, and the scaling law of dissemination stability on distance and averaging time is discussed. The preliminary extrapolation shows that the dissemination stability may reach $1\\times10^{-12}/s$ in ground-to-satellite synchronization, which far exceeds all present methods, and is worthy for further study.

  15. UTag: Long-range Ultra-wideband Passive Radio Frequency Tags

    SciTech Connect (OSTI)

    Dowla, F

    2007-03-14T23:59:59.000Z

    Long-range, ultra-wideband (UWB), passive radio frequency (RF) tags are key components in Radio Frequency IDentification (RFID) system that will revolutionize inventory control and tracking applications. Unlike conventional, battery-operated (active) RFID tags, LLNL's small UWB tags, called 'UTag', operate at long range (up to 20 meters) in harsh, cluttered environments. Because they are battery-less (that is, passive), they have practically infinite lifetimes without human intervention, and they are lower in cost to manufacture and maintain than active RFID tags. These robust, energy-efficient passive tags are remotely powered by UWB radio signals, which are much more difficult to detect, intercept, and jam than conventional narrowband frequencies. The features of long range, battery-less, and low cost give UTag significant advantage over other existing RFID tags.

  16. Field Deployment of Prototype Antenna Tiles for the Mileura Widefield Array--Low Frequency Demonstrator

    E-Print Network [OSTI]

    Judd D. Bowman; David G. Barnes; Frank H. Briggs; Brian E. Corey; Merv J. Lynch; N. D. Ramesh Bhat; Roger J. Cappallo; Sheperd S. Doeleman; Brian J. Fanous; David Herne; Jacqueline N. Hewitt; Chris Johnston; Justin C. Kasper; Jonathon Kocz; Eric Kratzenberg; Colin J. Lonsdale; Miguel F. Morales; Divya Oberoi; Joseph E. Salah; Bruce Stansby; Jamie Stevens; Glen Torr; Randall Wayth; Rachel L. Webster; J. Stuart B. Wyithe

    2006-12-01T23:59:59.000Z

    Experiments were performed with prototype antenna tiles for the Mileura Widefield Array--Low Frequency Demonstrator (MWA-LFD) to better understand the widefield, wideband properties of their design and to characterize the radio frequency interference (RFI) between 80 and 300 MHz at the site in Western Australia. Observations acquired during the six month deployment confirmed the predicted sensitivity of the antennas, sky-noise dominated system temperatures, and phase-coherent interferometric measurements. The radio spectrum is remarkably free of strong terrestrial signals, with the exception of two narrow frequency bands allocated to satellite downlinks and rare bursts due to ground-based transmissions being scattered from aircraft and meteor trails. Results indicate the potential of the MWA-LFD to make significant achievements in its three key science objectives: epoch of reionziation science, heliospheric science, and radio transient detection.

  17. Relative stereociliary motion in a hair bundle opposes amplification at distortion frequencies

    E-Print Network [OSTI]

    Andrei S. Kozlov; Thomas Risler; Armin J. Hinterwirth; A. J. Hudspeth

    2012-03-08T23:59:59.000Z

    Direct gating of mechanoelectrical-transduction channels by mechanical force is a basic feature of hair cells that assures fast transduction and underpins the mechanical amplification of acoustic inputs. But the associated nonlinearity - the gating compliance - inevitably distorts signals. Because reducing distortion would make the ear a better detector, we sought mechanisms with that effect. Mimicking in vivo stimulation, we used stiff probes to displace individual hair bundles at physiological amplitudes and measured the coherence and phase of the relative stereociliary motions with a dual-beam differential interferometer. Although stereocilia moved coherently and in phase at the stimulus frequencies, large phase lags at the frequencies of the internally generated distortion products indicated dissipative relative motions. Tip links engaged these relative modes and decreased the coherence in both stimulated and free hair bundles. These results show that a hair bundle breaks into a highly dissipative serial arrangement of stereocilia at distortion frequencies, precluding their amplification.

  18. Cell signalling and phospholipid metabolism

    SciTech Connect (OSTI)

    Boss, W.F.

    1990-01-01T23:59:59.000Z

    These studies explored whether phosphoinositide (PI) has a role in plants analogous to its role in animal cells. Although no parallel activity of PI in signal transduction was found in plant cells, activity of inositol phospholipid kinase was found to be modulated by light and by cell wall degrading enzymes. These studies indicate a major role for inositol phospholipids in plant growth and development as membrane effectors but not as a source of second messengers.

  19. Sorting Signals of Borrelia Lipoproteins

    E-Print Network [OSTI]

    Schulze, Ryan Joseph

    2009-03-11T23:59:59.000Z

    in the cytoplasmic membrane (CM) (von Heijne,1989). The signal II peptide is characterized by the typical tripartite componentry of an amino-terminal positively- charged (N) domain, hydrophobic (H) core, and cleavage (C) region. Only the C- region differs... in the membrane to assist in the coordinated construction of large periplasm-spanning transport machinery. 8 Lipoproteins have important structural functions in bacteria. The well-characterized Braun?s lipoprotein (Lpp) and peptidoglycan...

  20. Expected geoneutrino signal at JUNO

    E-Print Network [OSTI]

    Strati, Virginia; Callegari, Ivan; Mantovani, Fabio; McDonough, William F; Ricci, Barbara; Xhixha, Gerti

    2014-01-01T23:59:59.000Z

    Constraints on the Earth's composition and on its radiogenic energy budget come from the detection of geoneutrinos. The KamLAND and Borexino experiments recently reported the geoneutrino flux, which reflects the amount and distribution of U and Th inside the Earth. The KamLAND and Borexino experiments recently reported the geoneutrino flux, which reflects the amount and distribution of U and Th inside the Earth. The JUNO neutrino experiment, designed as a 20 kton liquid scintillator detector, will be built in an underground laboratory in South China about 53 km from the Yangjiang and Taishan nuclear power plants. Given the large detector mass and the intense reactor antineutrino flux, JUNO aims to collect high statistics antineutrino signals from reactors but also to address the challenge of discriminating the geoneutrino signal from the reactor background.The predicted geoneutrino signal at JUNO is 39.7 $^{+6.5}_{-5.2}$ TNU, based on the existing reference Earth model, with the dominant source of uncertainty...