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Sample records for fred hutchinson cancer

  1. FRED HUTCHINSON CANCER RESEARCH CENTER RESEARCH MISCONDUCT POLICY AND PROCEDURES

    E-Print Network [OSTI]

    Brent, Roger

    agencies, the Office of the Inspector General ("OIG") generally carries out enforcement of research of interest. (See: http://www.fhcrc.org/intranet/general_counsel/conflict_interest_2002.pdf) The Center shall and reporting research, its philosophy and policy of dealing with and reporting possible research misconduct

  2. Julie Gralow, MD Director Breast Medical Oncology, Seattle Cancer Care Alliance

    E-Print Network [OSTI]

    Brent, Roger

    Julie Gralow, MD Director Breast Medical Oncology, Seattle Cancer Care Alliance Founder Care Alliance, as well as a Member of the Clinical Research Division of the Fred Hutchinson Cancer

  3. Enhancing cancer therapeutics using size-optimized magnetic fluid hyperthermia

    E-Print Network [OSTI]

    Krishnan, Kannan M.

    Enhancing cancer therapeutics using size-optimized magnetic fluid hyperthermia Amit P. Khandhar, R cancer therapeutics using size-optimized magnetic fluid hyperthermia Amit P. Khandhar,1 R. Matthew & Engineering, Seattle, Washington 98195, USA 2 Fred Hutchinson Cancer Research Center, Division of Clinical

  4. Faculty Position -Global Pediatric Oncology The Vaccine and Infectious Disease Division (VIDD) of the Fred Hutchinson Cancer Research Center seeks

    E-Print Network [OSTI]

    Brent, Roger

    and translational research on Burkitt lymphoma in low- and middle-income countries. The primary responsibility of this position is to work with a multi- disciplinary team of established investigators in the field of global-transplant oncology. The position provides a joint appointment, at rank, with the University of Washington's School

  5. Fred Loebl

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformation Current HABFES OctoberEvanServicesAmesFour Los AlamosFranklinFred Loebl Fred

  6. Henry and Fred Learn about Lead

    E-Print Network [OSTI]

    Holsinger, Kent

    Henry and Fred Learn about Lead Joan Bothell Activity book #12;Henry and Fred Learn about Lead the children's storybook Henry and Fred Learn about Lead/Enrique y Federico aprenden sobre el plomo (2003 of this activity book. The Henry and Fred storybook is about keeping children safe from lead poisoning, a serious

  7. Search The Hutchinson Report NewsSearch The Hutchinson Report News

    E-Print Network [OSTI]

    Huang, Jianyu

    , New Mexico, California, and Washington D.C. with a potential audience of 10 million listeners. The Hutchinson Report Network blends standard radio, internet radio, internet TV and a global web stream. Radio (Los Angeles) Pacifica Network Public Radio Saturday Noon-1:00 PM PST Audio and Internet TV Streamed

  8. Fred C. Hartman | ornl.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Fred C. Hartman (1988) February 28, 2014 Life Sciences Division For advances in protein structure and enzyme mechanisms by use of affinity labeling and site-directed mutagenesis....

  9. Introducing FRED, Enabling Unique Visualization and Manipulation...

    Open Energy Info (EERE)

    Introducing FRED, Enabling Unique Visualization and Manipulation of Energy Data at Multiple Scales Home > Groups > OpenEI Community Central Sfederspiel's picture Submitted by...

  10. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar2-0057-EA Jump to:ofEnia SpA JumpGmbH EFCFBA FrancoFRED Home > Groups >

  11. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar2-0057-EA Jump to:ofEnia SpA JumpGmbH EFCFBA FrancoFRED Home > Groups

  12. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoopButtePowerEdisto Electric Coop,ErosionNewCoal Jump to: navigation, search Name:FRED

  13. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoopButtePowerEdisto Electric Coop,ErosionNewCoal Jump to: navigation, searchMapFRED

  14. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoopButtePowerEdisto Electric Coop,ErosionNewCoal Jump to: navigation,FRED Home >

  15. Fred Lipschultz | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE:FinancingPetroleum12, 2015ExecutiveFluorescent LampFort Collins,47328 Vol. 77,FrancesFred

  16. A video interview with Fred Dylla, AIP CEO (SPIE Newsroom) |...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    https:www.jlab.orgnewsarticlesvideo-interview-fred-dylla-aip-ceo-spie-newsroom A video interview with Fred Dylla, AIP CEO Dylla was interviewed at Photonics West 2008 by Rich...

  17. Hutchinson Community College Transfer Program to University of Kansas

    E-Print Network [OSTI]

    Engineering Physics 4 PY 202 Engineering Physics 2 5 GE3N CHEM 130 Chemistry 5 CH 105 or 110H Chemistry 5 GE12 Chemistry 5 CH 201 Organic Chemistry 1 5 Petroleum Engineering: KU Course Requirements Hutchinson Chemical Engineering ~updated April 28, 2015 2 CHEM 135 Chemistry 2 5 CH 106 or 111H Chemistry 2 5 GE12, GE

  18. Plasticity at the micron scale John W. Hutchinson*

    E-Print Network [OSTI]

    Hutchinson, John W.

    Plasticity at the micron scale John W. Hutchinson* Division of Engineering and Applied Sciences into the plastic range: smaller is stronger. This eect has important implications for an increasing number of applications in electronics, structural materials and MEMS. Plastic behavior at this scale cannot

  19. Hutchinson Community College TRANSFER PROGRAM TO THE UNIVERSITY OF KANSAS

    E-Print Network [OSTI]

    Photo Media-B.F.A Number to call at KU for advising: (785) 864-3500 Website: http/Senior level for graduation. Photo Media Requirements: KU Course Requirements Hutchinson Equivalents ENGLISH (3 Courses) Core ENGL 101 Composition 3 EN 100 or 101 or 103H English Composition 3 GE21 ENGL 102 Critical

  20. Real numbers and other completions Fred Richman

    E-Print Network [OSTI]

    Richman, Fred

    Real numbers and other completions Fred Richman Florida Atlantic University Boca Raton, FL 33431 11 March 2007 Abstract A notion of completeness and completion suitable for use in the absence of countable choice is developed. This encompasses the con- struction of the real numbers as well as the completion

  1. South Hutchinson, Kansas: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page| Open Energy Information Serbia-Enhancing Capacity forSiliciumEnergyHouston, Texas: Energy Resources JumpHutchinson,

  2. The Gemini Observatory Science Operations Plan Phil Puxley, Fred Gillett, Matt Mountain and Doug Simons

    E-Print Network [OSTI]

    The Gemini Observatory Science Operations Plan Phil Puxley, Fred Gillett, Matt Mountain and Doug Gemini Observatory Science Operations Plan Phil Puxley, Fred Gillett, Matt Mountain and Doug Simons

  3. Fred Olsen Renewables Ltd | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar2-0057-EA Jump to:ofEnia SpAFlex FuelsEnergyInc FFC Jump to:CooperativeFred

  4. Fred L. Brown | Department of Energy

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious Rank EERE: Alternative Fuelsof Energy Services » ProgramPolicySenateFlyer, Title VIFormatBlogFred L.

  5. The Gemini Observatory Science Operations Plan Phil Puxley, Fred Gillett, Matt Mountain and Doug Simons

    E-Print Network [OSTI]

    The Gemini Observatory Science Operations Plan Phil Puxley, Fred Gillett, Matt Mountain and Doug; The Gemini Observatory Science Operations Plan Phil Puxley, Fred Gillett, Matt Mountain and Doug Simons

  6. http://www.treknature.com/gallery/photo160544.htm Hutchinson's Life History

    E-Print Network [OSTI]

    Jodice, Patrick

    revolutionized his fields of study Open the World to new ideas Won numerous awards including: Franklin Medal Pellegrino an small island off the coast of Italy Corixa, the genus of a water bugs Hutchinson found://globalextinction.org/EltonFW.jpg #12;20% energy exchange (Lindeman, 1942) 13% energy exchange (Slobodkin) In 1960s, they had no way

  7. Cellular metals Anthony G Evans*, John W Hutchinson* and Michael F Ashby?

    E-Print Network [OSTI]

    Hutchinson, John W.

    233 Cellular metals Anthony G Evans*, John W Hutchinson* and Michael F Ashby? The property profile exhibited by cellular metals identifies several applications, especially in technologies requiring the properties that govern these performance benefits and the cellular architecture, cell morphology and density

  8. Computer Science and Decision Theory Fred S. Roberts 1

    E-Print Network [OSTI]

    Computer Science and Decision Theory Fred S. Roberts 1 DIMACS Center, Rutgers University in the social and decision sciences of newer decision-theoretic methods developed with computer science applications in mind. The paper deals with the relation between computer science and decision-theoretic methods

  9. What Tacoma Taught Us Dag Johansen Fred B. Schneider

    E-Print Network [OSTI]

    Schneider, Fred B.

    What Tacoma Taught Us Dag Johansen Fred B. Schneider y and Robbert van Renesse y 1 Introduction Tacoma is a system for supporting processes|so called agents|whose ex- ecution moves from processor versions of Tacoma provide support for agents written in C, C++, ML, Perl, Python, Scheme, and Visual Basic

  10. High resolution seismic reflection to characterize small scale mechanisms of large scale natural dissolution in the Hutchinson Salt Member

    E-Print Network [OSTI]

    Judy, Brett

    2015-05-31

    High resolution seismic reflection imaging of the local scale processes along the eastern natural dissolution front of the Hutchinson Salt Member were correlated with its regional scale progression to define a more complete dissolution model...

  11. Corey Casper, MD Head, Program in Global Oncology

    E-Print Network [OSTI]

    Brent, Roger

    Corey Casper, MD Head, Program in Global Oncology Member, Vaccine and Infectious Disease and Public of Washington Dr. Casper focuses on infection-related cancers and cancer in low-resource settings. He is the Head of the Program in Global Oncology at the Fred Hutchinson Cancer Research Center, where he is also

  12. A review of "The Works of Lucy Hutchinson" edited by Reid Barbour and David Norbrook 

    E-Print Network [OSTI]

    Caldwell, Tanya

    2013-01-01

    , eds. ?e Works of Lucy Hutchinson. Volume I: Translation of Lucretius. ? parts. Latin text ed. by Maria Cristina Zerbino. Oxford: Oxford University Press, ????. cxlvi + ??? pp. + ?? illus. $???.??. Review... by Maria Cristina Zerbino. ?e translation appears on the right hand page and the Latin on the left. ?e texts are presented, as the editor?s note, as close to the original form as possible. ?ere is no modernization of spelling or letters, and the font...

  13. FRED+free energy database | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar2-0057-EA Jump to:ofEnia SpA JumpGmbH EFCFBA FrancoFRED Home >

  14. The mechanics of coating delamination in thermal gradients A.G. Evans a,, J.W. Hutchinson b

    E-Print Network [OSTI]

    Hutchinson, John W.

    The mechanics of coating delamination in thermal gradients A.G. Evans a,, J.W. Hutchinson b in revised form 16 March 2007 Available online 27 March 2007 Abstract Oxide coatings used for various stress gradient in the coating, governed by these thermal circumstances. Two extreme cool-down scenarios

  15. The Ideal Evaluation of a Risk Prediction Model: A Randomized Clinical Trial

    E-Print Network [OSTI]

    Brent, Roger

    The Ideal Evaluation of a Risk Prediction Model: A Randomized Clinical Trial Holly Janes Fred Hutchinson Cancer Research Center 1/25 #12;Context Often a risk prediction model is developed to identify high risk subjects who can benefit from preventative therapy E.g. Framingham risk model to identify

  16. Nucleic Acids Research, 2009, 113 doi:10.1093/nar/gkp004

    E-Print Network [OSTI]

    Monnat, Ray

    of Washington, Box 357705, Seattle, WA 98195, 2 Northwest Genome Engineering Consortium, Seattle, WA, 3 98195, 4 Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N. A3 (collectively termed mCreIs or mMsoIs) were characterized in detail by using a combination of biochemical

  17. Minutes of the Chancellor's Cabinet Meeting of Monday, February 24, 2014 Present: Les Johnson, Barbara Keinath, Peter Phaiah, Tricia Sanders, Andrew Svec, Fred Wood

    E-Print Network [OSTI]

    Minnesota, University of

    , Barbara Keinath, Peter Phaiah, Tricia Sanders, Andrew Svec, Fred Wood Meeting began at 8:30. I. Minutes high awareness of and build support for UMC's Wellness Center, Fred Wood is meeting tonight

  18. Fred Richard Mynatt, 1981 | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (Journal Article)Forthcoming Upgrades to theGameFranklin to beFred L.Fred

  19. What Tacoma Taught Us Dag Johansen \\Lambda Fred B. Schneider y and Robbert van Renesse y

    E-Print Network [OSTI]

    Schneider, Fred B.

    What Tacoma Taught Us Dag Johansen \\Lambda Fred B. Schneider y and Robbert van Renesse y 1 Introduction Tacoma is a system for supporting processes---so called agents---whose ex­ ecution moves from. The current versions of Tacoma provide support for agents written in C, C++, ML, Perl, Python, Scheme

  20. 1999 13: 2940-2945Genes Dev. Aime M. Dudley, Claire Rougeulle and Fred Winston

    E-Print Network [OSTI]

    Winston, Fred

    1999 13: 2940-2945Genes Dev. Aimée M. Dudley, Claire Rougeulle and Fred Winston at a post and Spt20 in the recruitment of TBP. Received September 8, 1999; revised version accepted September 28, 1999. In eukaryotes, transcription initiation by RNA polymer- ase II (Pol II) requires not only

  1. 3M: Hutchinson Plant Focuses on Heat Recovery and Cogeneration During Plant-Wide Energy-Efficiency Assessment

    SciTech Connect (OSTI)

    Not Available

    2003-06-01

    3M performed a plant-wide energy efficiency assessment at its Hutchinson, Minnesota, plant to identify energy- and cost-saving opportunities. Assessment staff developed four separate implementation packages that represented various combinations of energy-efficiency projects involving chiller consolidation, air compressor cooling improvements, a steam turbine used for cogeneration, and a heat recovery boiler for two of the plant's thermal oxidizers. Staff estimated that the plant could save 6 million kWh/yr in electricity and more than 200,000 MMBtu/yr in natural gas and fuel oil, and avoid energy costs of more than$1 million during the first year.

  2. 3M: Hutchinson Plant Focuses on Heat Recovery and Cogeneration during Plan-Wide Energy-Efficiency Assessment

    SciTech Connect (OSTI)

    2003-06-01

    3M performed a plant-wide energy efficiency assessment at its Hutchinson, Minnesota, plant to identify energy- and cost-saving opportunities. Assessment staff developed four separate implementation packages that represented various combinations of energy-efficiency projects involving chiller consolidation, air compressor cooling improvements, a steam turbine used for cogeneration, and a heat recovery boiler for two of the plant's thermal oxidizers. Staff estimated that the plant could save 6 million kWh/yr in electricity and more than 200,000 MMBtu/yr in natural gas and fuel oil, and avoid energy costs of more than $1 million during the first year.

  3. About the role of the Higgs boson in the early Fred Jegerlehner, DESY Zeuthen/Humboldt University Berlin

    E-Print Network [OSTI]

    Röder, Beate

    About the role of the Higgs boson in the early universe Fred Jegerlehner, DESY Zeuthen ­ April 16-17, 2014 5 #12;The Higgs is special! Ì the Higgs boson was invented 1964 by Higgs, Englert

  4. Library and Information Technology Final Report Fred Heath -Dean & Director, Sterling C. Evans Library, On-Campus Co-Chair

    E-Print Network [OSTI]

    Library and Information Technology Final Report Members Fred Heath - Dean & Director, Sterling C Provost for Information Technology, and Associate Professor, Department of Electrical Engineering, Sterling C. Evans Library M. Michael Park - Attorney at Law Linda Parrish '78 - Professor, Department

  5. Fred N. Mortensen, 2004 | U.S. DOE Office of Science (SC)

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantityBonneville Power Administration would likeUniverse (Journal Article)Forthcoming Upgrades to theGameFranklin to beFred L.

  6. Electron Acoustic Waves in Pure Ion Plasmas Francois Anderegg, C. Fred Driscoll, Daniel H.E. Dubin and

    E-Print Network [OSTI]

    California at San Diego, University of

    Electron Acoustic Waves in Pure Ion Plasmas Francois Anderegg, C. Fred Driscoll, Daniel H.E. Dubin-0319 Abstract. Electron Acoustic Waves (EAWs) are the low frequency branch of electrostatic plasma waves-Gould wave, EAW PACS: 52.27.Jt, 52.35.Fp, 52.35.Sb INTRODUCTION The near-linear Electron Acoustic Wave (EAW

  7. Smart Card Security Kostas Markantonakis I.1, Keith Mayes I.2, Michael Tunstall I.3, Fred Piper I.4,

    E-Print Network [OSTI]

    Mayes, Keith

    Chapter I Smart Card Security Kostas Markantonakis I.1, Keith Mayes I.2, Michael Tunstall I.3, Fred Piper I.4, and Damien Sauveron I.5 I.6 . I.1 Introduction I.2 Smart cards and Cryptography I.3 Smart card Specific Attacks Sensitive systems that are based on smart cards use protocols and algorithms

  8. A Conference Control Protocol for Highly Interactive Video-conferencing Ruibiao Qiu Fred Kuhns Jerome R. Cox

    E-Print Network [OSTI]

    A Conference Control Protocol for Highly Interactive Video-conferencing Ruibiao Qiu Fred Kuhns demand for video-conferences conducting over broad- band wide area networks. In this paper, we present a conference control protocol for a highly interactive conference paradigm and its collaboration environment

  9. A Pervasive Computing Solution to Asset, Problem and Knowledge Management Suman K. Kalia, Charles C. Tappert, Allen Stix, and Fred Grossman

    E-Print Network [OSTI]

    Tappert, Charles

    . Tappert, Allen Stix, and Fred Grossman School of Computer Science and Information Systems Pace University desktop support team across the U.S. Introduction The following quote (IBM Pervasive Computing Website computing" is relatively new, its concept has historical precedence. Companies like IBM (IBM Redbook 1995

  10. Activities of the NASA Exploration Team Human-Robotics Working Group Chris Culbert, Jen Rochlis, Fred Rehnmark, David Kortenkamp, Kevin Watson,

    E-Print Network [OSTI]

    Kortenkamp, David

    Activities of the NASA Exploration Team Human-Robotics Working Group Chris Culbert, Jen Rochlis, Fred Rehnmark, David Kortenkamp, Kevin Watson, Rob Ambrose, Ron Diftler, Brenda Ward NASA/Johnson Space Center Liam Pedersen NASA/Ames Research Center Chuck Weisbin, Guillermo Rodriguez, Bob Easter Jet

  11. J. Fred and Wilma Holly Fellowship for Excellence in Research. This is a one-time payment of $5000. This fellowship is given to the student with the best "third-year research

    E-Print Network [OSTI]

    Grissino-Mayer, Henri D.

    . This fellowship is given to the student with the best "third-year research paper". The winner will be determined semester of the following year to receive the Fellowship. J. Fred and Wilma Holly Fellowship for Published-authored, that are published or accepted for publication during the previous calendar year will be considered. The fellowship

  12. Fred Jelinek Mark Liberman

    E-Print Network [OSTI]

    , exemplifying, and promoting what has become the standard research paradigm in an even wider range of fields separate themes and story lines. The theme of the first epic is the return of Information Theory to center stage in speech and language processing; and the theme of the second epic is the development of a new

  13. YEAST GENETICS Fred Winston

    E-Print Network [OSTI]

    Winston, Fred

    desired mutation can be incorporated into the S. cerevisiae genome, allowing powerful genetic analyses online at http://www.ergito.com/main.jsp?bcs=GNTC.2.7.1 Genetics Introduction | SECTION 7.1 1 © 2004

  14. Analysis of Senate Bill 961: Cancer Treatment

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2010-01-01

    endometrial cancer, ovarian cancer, uterine cancer, andagents No Epithelial ovarian cancer, Hodgkins lymphomacancer, endometrial cancer, ovarian cancer, uterine sarcoma

  15. BREAST CANCER SUPPORT RESOURCES Smilow Cancer Hospital

    E-Print Network [OSTI]

    O'Hern, Corey S.

    BREAST CANCER SUPPORT RESOURCES Smilow Cancer Hospital · Early Stage Breast Cancer Support Group · Advanced Stage Cancer Support Group · IMPACT ­ Young Cancer Survivors' Group Contact: Angela Khairallah, LCSW at 203-200-2360 Reach to Recovery ­ American Cancer Society 1-800-227-2345 www.cancer.org Sisters

  16. STARTLINK COMPOSITE HOUSING J. A. Hutchinson1

    E-Print Network [OSTI]

    Mottram, Toby

    a "green" roof which retains water for evaporative cooling and the thermal mass of the ground below efficient housing. By avoiding steel and concrete, Startlink houses are quick to build, environmentally

  17. JOHN HUTCHINSON apoleon Bonaparte's military excur-

    E-Print Network [OSTI]

    Daley, Monica A.

    French naturalist, Étienne Geoffroy Saint-Hilaire, to cross paths with a strange fish that had paired lungs and could `walk' on land on its stubby, lobe-like fins. In 1802, he dubbed this fish "Polyptère environment (Fig. 1). They then studied how the fish from the two groups moved on land, and how the shape

  18. Nanotechnology for Teachers Dr. John S. Hutchinson

    E-Print Network [OSTI]

    Engineering? Nanobots? Science Fiction! #12;"Nano": How small is that, really? Mountain 1 km 1000 m 0.001 km

  19. Hutchinson, Kansas: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History View NewTexas: Energy Resources JumpNewTexas: EnergyHunterdon

  20. Hutchinson Utilities Comm | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar2-0057-EA JumpDuimen RiverScoringUtilities Comm Jump to: navigation, search

  1. Hutchinson Utilities Commission - Commercial Energy Efficiency Program |

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i nA Guide to TappingWORKof Energy BeforeSavingssRankingEnergy? |Department

  2. Hutchinson Utilities Commission - Residential Energy Efficiency Program |

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of Natural GasAdjustmentsShirleyEnergyTher i nA Guide to TappingWORKof Energy BeforeSavingssRankingEnergy?

  3. Analysis of Assembly Bill 1000: Cancer Treatment

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01

    endometrial cancer, ovarian cancer, uterine cancer, andagents No Epithelial ovarian cancer, melanoma, multiplein advanced, inoperable ovarian cancer; used as palliative

  4. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar2-0057-EA Jump to:ofEnia SpA JumpGmbH EFCFBA Franco BrasileiraFONSIFREDHome

  5. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar2-0057-EA Jump to:ofEnia SpA JumpGmbH EFCFBA Franco

  6. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoopButtePowerEdisto Electric Coop,ErosionNewCoal Jump to: navigation, search

  7. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoopButtePowerEdisto Electric Coop,ErosionNewCoal Jump to: navigation, searchMap Type

  8. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoopButtePowerEdisto Electric Coop,ErosionNewCoal Jump to: navigation, searchMap

  9. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoopButtePowerEdisto Electric Coop,ErosionNewCoal Jump to: navigation,

  10. OpenEI Community - FRED

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIXsourceII Jump to:InformationInformationOorjaen The EnergyInvitationFOA aimed

  11. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LIST OFAMERICA'SHeavy Electricals LtdEcowindEnvironmentalEscoEverPowerExelonFPCFRED

  12. Josephine Ford Cancer Center Cancer Research Programs

    E-Print Network [OSTI]

    Finley Jr., Russell L.

    Josephine Ford Cancer Center Cancer Research Programs presented to WSU SOM PAD January 10, 2012 presented by Sandra A. Rempel, Ph.D. Associate Director of Research, JFCC #12;JFCC Cancer Research Programs Cancer Epidemiology, Prevention and Control Program Members: Gwen Alexander, Andrea Cassidy

  13. Comprehensive Cancer Center Nutrition

    E-Print Network [OSTI]

    Anderson, Paul R.

    Comprehensive Cancer Center Nutrition Bldg.Pedestrian Link from Ardmore Tower to Comprehensive Cancer Center on Ground Floor Emergency Room Parking Ardmore Cafeteria Ardmore Tower North Tower Janeway

  14. Lung Cancer James Nguyen

    E-Print Network [OSTI]

    Brutlag, Doug

    Lung Cancer James Nguyen Biochemistry 118Q Doug Brutlag A Case Study of Genetics and Environment #12;Lung Cancer · Leading cause of cancer for men and women in United States · Every year, about 164,000 new cases are diagnosed in the US, with an estimated 157,000 deaths. · Leading cause of cancer death

  15. The National Cancer Institute,

    E-Print Network [OSTI]

    The National Cancer Institute, International Cancer Information Center Bldg. 82, Rm 123 Bethesda, MD 20892 The National Cancer Institute (NCI) is part of the Federal Government. NCI coordinates the government's cancer research program. It is the largest of the 17 biomedical research institutes and centers

  16. AT NORTHWESTERN EARLY CANCER DETECTION

    E-Print Network [OSTI]

    Chisholm, Rex L.

    --including lung cancer, pancreatic cancer, and ovarian cancer-- there is simply no screening option available, such as pancreatic, ovarian, and lung cancer. · Improve existing screening techniques, such as those for colon cancer, with the THE CANCER INSTITUTES AT NORTHWESTERN MEDICINE EARLY CANCER DETECTION TECHNOLOGIES INSTITUTE

  17. CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER

    E-Print Network [OSTI]

    Sherman, S. Murray

    CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRA NSFO RMING LIVES THRO UG H RE SE ARC H #12;CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRANSFORMING LIVES THROUGH RESEARCH #12;II AACR Cancer Progress Report 2014

  18. Cancer Stage at Diagnosis, 2013

    E-Print Network [OSTI]

    2013-01-01

    of avoiding death due to a particular cancer. Stage atdiagnosis by the American Joint Committee on Cancer (AJCC) Cancer Staging Manual, sixth edition. Source:

  19. Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

    E-Print Network [OSTI]

    2006-01-01

    1996): Nutrition and breast cancer. Cancer Causes Control 7:of premenopausal breast cancer. Cancer Epidemiol.BiomarkersDiagnosis Weight Gain and Breast Cancer Recurrence In Women

  20. Familial Breast Cancer Julie Saffarian

    E-Print Network [OSTI]

    Brutlag, Doug

    Familial Breast Cancer Julie Saffarian Genomics & Medicine Stanford University #12;Definitions metastasis" ­ Wikipedia.com What is Breast Cancer? - Breast Cancer is a disease in which the uncontrollable Breast Cancer? - Sporadic Breast Cancer is non-hereditary and represents 85-90% of Cancer cases

  1. Cancer: A suppression switch

    E-Print Network [OSTI]

    Starobinets, H; Debnath, J

    2013-01-01

    Cancer A suppression switch The status of the protein p53it seems that p53 acts as a switch in pancreatic cancer thatthe ability of p53 to switch the clinical outcome of

  2. Comprehensive Cancer Center Nutrition

    E-Print Network [OSTI]

    Anderson, Paul R.

    Comprehensive Cancer Center Nutrition Bldg.Pedestrian Link from Ardmore Tower to Comprehensive Cancer Center on Ground Floor Emergency Room Parking Pedestrian Link to Parking on 4th Floor Surgical

  3. PROSTATE CANCER EVIDENCE ACADEMY

    E-Print Network [OSTI]

    Bushman, Frederic

    PROSTATE CANCER EVIDENCE ACADEMY CME/CNE-Certified Course The Inn at Penn 3600 Sansom Street:30 PM R E G I S T E R O N L I N E AT PENNCMEONLINE.COM/NODE/57378 #12;OVERVIEW The Prostate Cancer, and model programs that are proven effective or being studied to improve prostate cancer prevention, control

  4. Evidence That New Hypnotics Cause Cancer

    E-Print Network [OSTI]

    Kripke, Daniel F.

    2008-01-01

    use and risk of epithelial ovarian cancer. Cancer Epidemiol.and risk of epithelial ovarian cancer: evidence from twowere associated with ovarian cancer (Harlow et al. 1998;

  5. FIGHTING CANCER Cancer Research at the University of Notre Dame

    E-Print Network [OSTI]

    Buechler, Steven

    FIGHTING CANCER Cancer Research at the University of Notre Dame College of Science 168 Hurley Hall Fighting Cancer 5 Ani Aprahamian Isotopes for cancer therapy and immuno-diagnosis 7 Brian Baker Development of improved immunological therapies for cancer based on cellular immunity 9 Suzanne Bohlson Inflammation

  6. CANCER GENETICS & PREVENTION HEREDITARY BREAST AND OVARIAN CANCER

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    CANCER GENETICS & PREVENTION HEREDITARY BREAST AND OVARIAN CANCER SYNDROME (HBOC) ­ BRCA1 PATIENT INFORMATION What is Hereditary Breast and Ovarian Cancer syndrome? Hereditary Breast and Ovarian Cancer syndrome (HBOC) is the most common hereditary form of breast and ovarian cancer. About 2% of women

  7. Cancer Due to Prolonged Inflammation

    E-Print Network [OSTI]

    Lingampalli, Nithya

    2013-01-01

    Werb J. Inflammation and cancer. Nature. 2002 December 19;J.T. , Szabo E. , et al. Cancer and inflammation: PromiseInflammation, a Key Event in Cancer Development. Molecular

  8. Bismuth 213 Cancer Treatment

    ScienceCinema (OSTI)

    None

    2013-05-28

    See how INL scientists are increasing supplies of radioactive medical isotopes to treat cancer. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

  9. Sample-Specific Cancer Pathway Analysis Using PARADIGM

    E-Print Network [OSTI]

    Benz, Stephen Charles

    2012-01-01

    associated with Ovarian Cancer 29 3.2.3 Di?erentiallyOvarian Cancer . . . . . . . . . . . . . . . . . . . . . .Ovarian Cancer) . . . . . . . . . . . . . . . . . . . . . .

  10. 18 October 2002 From: Fred Heutte

    E-Print Network [OSTI]

    energy development, which have been monitored by staff from both BPA and the Council. My public testimony The 1980 law stands as a continuing monument to appropriate planning and program management for energy criteria, well suited to our river-based electric energy system and respectful of the region's institutions

  11. Mathematics of Planet Earth Fred Roberts

    E-Print Network [OSTI]

    that understanding, progress in the mathematical sciences is essential. Dust storm in Mali #12;3 The MPE Challenge storm in Mali Deepwater Horizon Oil Spill #12;4 The MPE Challenge · Need to understand ­ Impact of our sciences provide. Dust storm in Mali #12;5 NSF SEES: Science, Engineering, and Education for Sustainability

  12. FRee Energy Data (FRED) | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTIONRobertsdale, AlabamaETEC GmbH JumpEllenville,PowerEvaporative| OpenEnergyFHAFRP Policy 16:FRee

  13. FRED Overview Slides | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar2-0057-EA Jump to:ofEnia SpA JumpGmbH EFCFBA Franco BrasileiraFONSIFRED

  14. fred andreas | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX ECoop IncIowa (UtilityMichigan)data book Home

  15. OpenEI Community - fred andreas

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIXsourceII JumpQuarterly Smart Grid Data available for download onst,/0 enBig CleanNew

  16. Inflammation & Inflammation & cancer

    E-Print Network [OSTI]

    Beimel, Amos

    Tam & tnf dc cytokines metastasis metabolism #12;22 chemokine gradient in cancer (Balkwill et al. 2004 1861) Wound healing dc Tam & tnf cytokines metastasis therapeutics metabolism inflammation The end #12 & tnf cytokines metastasis metabolism #12;4 Motivation Cancer as an overhealing wound Lets Go! Wound

  17. Molecular & Cellular Biology Program Departmental Retreats Autumn 2014

    E-Print Network [OSTI]

    Doty, Sharon Lafferty

    Molecular & Cellular Biology Program Departmental Retreats ­ Autumn 2014 Z:\\FRONT DESK DOCUMENTS Hutchinson Cancer Research Center (FHCRC) 1100 Fairview Ave. N. Seattle, WA 98109-1024 Molecular & Cellular

  18. Cancer Cell Survival of Cancer Cells Is Maintained

    E-Print Network [OSTI]

    Leps, Jan "Suspa"

    Cancer Cell Article Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase,* and Mien-Chie Hung2,* 1Department of Cancer Biology 2Department of Molecular and Cellular Oncology The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA 3Present

  19. Mathematics for Cancer Research making optimal use of cancer data

    E-Print Network [OSTI]

    Coolen, ACC "Ton"

    Mathematics for Cancer Research making optimal use of cancer data ACC Coolen King's College London ACC Coolen (KCL) Mathematics in cancer research January 2015 1 / 63 #12;1 Quality of raw data Bayesian projects ... ACC Coolen (KCL) Mathematics in cancer research January 2015 2 / 63 #12;biomedical research

  20. CANCER GENETICS & PREVENTION HEREDITARY BREAST AND OVARIAN CANCER

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    CANCER GENETICS & PREVENTION HEREDITARY BREAST AND OVARIAN CANCER SYNDROME (HBOC) ­ BRCA2 PATIENT INFORMATION What is Hereditary Breast and Ovarian Cancer syndrome? People with BRCA2 alterations have a genetic condition called Hereditary Breast and Ovarian Cancer syndrome (HBOC). HBOC is caused by an error

  1. Hutchinson Community College Transfer Program to University of Kansas

    E-Print Network [OSTI]

    , GE12 PHSX 212 & 236 Engineering Physics 4 PY 202 Engineering Physics 2 5 GE3N CHEM 130 Chemistry 5 CH Engineering Physics 4 PY 202 Engineering Physics 2 5 GE3N Chemistry: Students may take the 2 courses below or wait and take CHEM 150 Chemistry for Engineers at KU CHEM 130 Chemistry 5 CH 105 or 110H Chemistry 5 GE

  2. Hutchinson Community College Transfer Program to University of Kansas

    E-Print Network [OSTI]

    Engineering Physics 2 5 GE3N CHEM 130 Chemistry 5 CH 105 or 110H Chemistry 5 GE12, GE3N Chemical Systems: KU, GE12 PHSX 212 & 236 Engineering Physics 4 PY 202 Engineering Physics 2 5 GE3N CHEM 130 Chemistry 5 CH Engineering Physics 2 5 GE3N CHEM 130 Chemistry 5 CH 105 or 110H Chemistry 5 GE12, GE3N KU Core Curriculum

  3. Hutchinson Community College Transfer Program to University of Kansas

    E-Print Network [OSTI]

    Engineering Physics 4 PY 202 Engineering Physics 2 5 GE3N Choose One: CHEM 130 Chemistry 5 CH 105 or 110HHutchinson Community College Transfer Program to University of Kansas B.S. Electrical Engineering & Computer Science (Computer Engineering, Computer Science, Electrical Engineering, Information Technology

  4. J. W. Hutchinson Division of Engineering and Applied Sciences,

    E-Print Network [OSTI]

    Hutchinson, John W.

    with minimal internal resis- tance. In this paper, sandwich plates are studied that are comprised of one solid of the same material with Young's modulus E, Poisson's ratio and yield stress Y . The Kagome-backed sand- wich plate in Fig. 2 has isotropic bending and stretching stiffness. The feature of the planar Kagome truss

  5. The evolution of locomotion in archosaurs John R. Hutchinson

    E-Print Network [OSTI]

    Hutchinson, John

    . Published by Elsevier SAS. All rights reserved. doi:10.1016/j.crpv.2005.09.002 #12;[48,70,97] has Laboratory, The Royal Veterinary College, University of London, Hatfield, AL9 7TA, UK Received 5 April 2005; accepted after revision 6 September 2005 Available online 07 February 2006 Written on invitation

  6. Hutchinson Community College Transfer Program to University of Kansas

    E-Print Network [OSTI]

    Core ECON 142 Princ of Microeconomics 3 EC 101 or 101H Microeconomics 3 GE3S ECON 144 Princ: Choose One: BIOL 150 Prn Molecular/Cellular 5 BI 104 Biology I 5 GE3N BIOL 152 Princ of Organismal

  7. Hutchinson County, South Dakota: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History View NewTexas: Energy Resources JumpNewTexas: EnergyHunterdon County,Huntley,Ohio:Hutchins,

  8. Hutchinson County, Texas: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QAsource History View NewTexas: Energy Resources JumpNewTexas: EnergyHunterdon County,Huntley,Ohio:Hutchins,Texas:

  9. Digital Tomosynthesis: Advanced Breast Cancer

    E-Print Network [OSTI]

    Hansma, Paul

    Digital Tomosynthesis: Advanced Breast Cancer Imaging Technique Max Wiedmann #12;Digital in CT. #12;Breast Cancer · The leading Cause of death for women ages 40-55. · Is only behind lung and bronchus cancer in terms of number of deaths in US. · Early detection of breast cancer is believed to save

  10. Survivorship Clinic Nutrition after Cancer

    E-Print Network [OSTI]

    Brent, Roger

    Survivorship Clinic Nutrition after Cancer Surviving cancer has a way of changing the way you look of practical, everyday questions that accompany life as a cancer survivor: Now what? How should I live successful treatment and are now leading vital, cancer- free lives. Maybe your doctor or dietitian has

  11. QUESTIONS & ANSWERS ABOUT LUNG CANCER

    E-Print Network [OSTI]

    QUESTIONS & ANSWERS ABOUT LUNG CANCER Q: What are the early signs of lung cancer? How would I know I have it? A: Some of the early warning signs of lung cancer are: · A cough that doesn't go away what may be causing these symptoms. Q: How is lung cancer diagnosed? A: Your doctor may do one or more

  12. Evidence That New Hypnotics Cause Cancer

    E-Print Network [OSTI]

    Kripke, Daniel F.

    2008-01-01

    medication use and risk of epithelial ovarian cancer.Cancer Epidemiol. Biomarkers Prev. , Hays, J. C. , Blazer,the likelihood of cancer causation is sufficiently strong

  13. Targeting mTOR in Pancreatic Cancer

    E-Print Network [OSTI]

    Soares, Heloisa Prado

    2015-01-01

    Parsons J, Kern SE. Progression model for pancreatic cancer.Clinical Cancer Research. 2000;6(N8):2969-72.Martinelli P. Pancreatic Cancer Development and Progression:

  14. Aneuploidy: Cancer's Fatal Flaw?

    E-Print Network [OSTI]

    Williams, Bret R.

    Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans carrying an aberrant karyotype. Yet, whether or how this condition contributes to tumorigenesis is not understood. Here we ...

  15. Eye Cancer- Cobalt Treatment 

    E-Print Network [OSTI]

    Unknown

    2011-08-17

    Ductal carcinoma in situ (DCIS) has been shown to be a precursor to invasive ductal cancer (IDC). Though the progression of DCIS to IDC is believed to be an important aspect of tumor aggressiveness, prognosis and molecular markers that predict...

  16. Targeting Breast Cancer Metastasis

    E-Print Network [OSTI]

    Mu, Ping

    Metastasis is the leading cause of breast cancer-associated deaths. Despite the significant improvement in current therapies in extending patient life, 30–40% of patients may eventually suffer from distant relapse and ...

  17. Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program Genetic Epidemiology of Cancer

    E-Print Network [OSTI]

    Weber, David J.

    Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program ­ Genetic Epidemiology of Cancer Associate Professor Tenuretrack Health is expanding research in Cancer Genetic Epidemiology to enrich an already robust campuswide

  18. Colorectal cancer and diet in Scotland 

    E-Print Network [OSTI]

    Theodoratou, Evropi

    2008-01-01

    Introduction Colorectal cancer is a cancer that forms in the tissues of the colon and/ or rectum and more than 95% of colorectal cancers are adenocarcinomas. It is the third most common cancer in incidence and mortality ...

  19. Hollow nanoshells for cancer diagnostics and therapy

    E-Print Network [OSTI]

    Sandoval, Sergio

    2012-01-01

    Protein Is a Marker for Ovarian-Cancer. Cancer Research,binding protein in ovarian cancers. International Journal ofTrophoblast and Ovarian-Cancer Antigen-Lk26 - Sensitivity

  20. CHEST Supplement Screening for Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    e78S CHEST Supplement Screening for Lung Cancer DIAGNOSIS AND MANAGEMENT OF LUNG CANCER, 3RD ED individuals). 3.2.2. In patients at risk for developing lung cancer, screening for lung cancer with sputum are age 55 to 74 and who have smoked for Background: Lung cancer is by far the major cause of cancer

  1. Pegfilgrastim prophylaxis is associated with a lower risk of hospitalization of cancer patients than filgrastim prophylaxis: a retrospective United States claims analysis of granulocyte colony-stimulating factors (G-CSF)

    E-Print Network [OSTI]

    2013-01-01

    cancer, lung cancer, ovarian cancer, or colorectal cancer.cancer, lung cancer, ovarian cancer, or colorectal cancerlung cancer, NHL, ovarian cancer, or colorectal cancer

  2. Cell Senescence: Aging and Cancer

    ScienceCinema (OSTI)

    Campisi, Judith

    2013-05-29

    Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals.

  3. Early Lung Cancer Detection Program

    Broader source: Energy.gov [DOE]

    Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

  4. Hindawi Publishing Corporation Prostate Cancer

    E-Print Network [OSTI]

    Ahn, Hongshik

    Hindawi Publishing Corporation Prostate Cancer Volume 2011, Article ID 176164, 7 pages doi:10.1155/2011/176164 Clinical Study Effect of Zoledronic Acid on Bone Mineral Density in Men with Prostate Cancer Receiving cancer is well recognized. We assessed the effects of quarterly infusion of zoledronic acid on bone

  5. Cancer Therapy with Particle Beams

    E-Print Network [OSTI]

    Olszewski Jr., Edward A.

    Cancer Therapy with Particle Beams #12;· The potential to use high energy particle beams to treat many types of cancer has been known even before their creation. · The availability of these treatments to be used in medicine, specifically for the treatment of certain cancers. His paper was published when

  6. Potential molecular targeting of splice variants for cancer treatment

    E-Print Network [OSTI]

    Blair, Christopher A; Zi, Xiaolin

    2011-01-01

    isoform contributes to ovarian cancer progression. Molin taxane-resistant ovarian cancer. Clin Cancer Res. 2011;Recent report in ovarian cancer has identified tumor-

  7. Diabetes and breast cancer : the women's healthy eating & living study

    E-Print Network [OSTI]

    Erickson, Kirsten Diann

    2011-01-01

    or experience significant weight gain after breast cancer.cohort of early-stage breast cancer patients [abstract]. Ja history of early stage breast cancer. Breast Cancer Res

  8. Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

    E-Print Network [OSTI]

    2006-01-01

    Hunter DJ, Willett WC (1996): Nutrition and breast cancer.Cancer Causes Control 7:56- 37. Weiderpass E, Braaten T,of premenopausal breast cancer. Cancer Epidemiol.Biomarkers

  9. Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer

    E-Print Network [OSTI]

    Spellman, Paul T.

    2011-01-01

    Rahman N.  ATM and breast cancer susceptibility.  Oncogene genes for inherited breast cancer.  Cancer Cell 2007;11: study identifies novel breast  cancer susceptibility loci.  

  10. Colon Cancer Is colon cancer a func.on of race or gene.cs?

    E-Print Network [OSTI]

    Brutlag, Doug

    Colon Cancer Is colon cancer a func.on of race or gene.cs? #12;Colon Cancer · What is colon cancer? · What genes are associated with colon cancer? · What external factors contribute to colon cancer? · What is done to diagnose

  11. THE CANCER INSTITUTES AT NORTHWESTERN MEDICINE

    E-Print Network [OSTI]

    Chisholm, Rex L.

    THE CANCER INSTITUTES AT NORTHWESTERN MEDICINE INTERNATIONAL RELATIONS PROGRAM THE INSTITUTES AT NORTHWESTERN MEDICINE #12;To maximize Northwestern's scientific contributions to the field of cancer Comprehensive Cancer Center of Northwestern University are partnering to create robust research collaborations

  12. Diet, MicroRNAs and Prostate Cancer

    E-Print Network [OSTI]

    Saini, Sharanjot; Majid, Shahana; Dahiya, Rajvir

    2010-01-01

    deregulation in human cancer. Cell Cycle. 2008;7:2643–6. 25.genomic regions involved in cancers. Proc Natl Acad Sci USA.A, Jacks T. MicroRNAs and cancer: short RNAs go a long way.

  13. Analysis of Senate Bill 255: Breast Cancer

    E-Print Network [OSTI]

    California Health Benefits Review Program

    2011-01-01

    women with stage 1 or II breast cancer who Lumpectomy plus=1.06 (0.56-2.00) II breast cancer who received mastectomya Fact Sheet on Breast Cancer Surgery/Partial Mastectomies

  14. YY1 modulates taxane response in epithelial ovarian cancer

    E-Print Network [OSTI]

    Matsumura, Noriomi

    2009-01-01

    A), but not to cisplatin (B) in ovarian cancer cell lines.al. Human epithelial ovarian cancer allelotype. Cancer Resallelotyping of human ovarian cancer. Br J Cancer 1994;69(

  15. Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk

    E-Print Network [OSTI]

    2009-01-01

    1996. Cigarette smoking and breast cancer. Cancer Epidemiol.Cigarette smoking and breast cancer. BMJ 310, 1431-1433.smoking, and the risk of breast cancer. Cancer Detect. Prev.

  16. Mathematical Toolkit Unlocks Some Cancer Secrets

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mathematical Models Shed New Light on Cancer Mutations Mathematical Models Shed New Light on Cancer Mutations Calculations Run at NERSC Pinpoint Rare Mutants More Quickly November...

  17. Developed by the Yale Lung Screening and Nodule Program at Yale Cancer Center Smilow Cancer Hospital at Yale-New Haven Copyright 2013, Yale Cancer Center

    E-Print Network [OSTI]

    O'Hern, Corey S.

    Developed by the Yale Lung Screening and Nodule Program at Yale Cancer Center Smilow Cancer Hospital at Yale-New Haven ©Copyright 2013, Yale Cancer Center Summary of Lung Cancer Screening Guidelines Program American Cancer Society (ACS) American Cancer Society. Interim Guidance on Lung Cancer Screening

  18. Breakthrough: Fighting Cancer with Nanoparticles

    ScienceCinema (OSTI)

    Rozhkova, Elena

    2013-04-19

    Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

  19. Breakthrough: Fighting Cancer with Nanoparticles

    SciTech Connect (OSTI)

    Rozhkova, Elena

    2012-01-01

    Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

  20. KEY FACTS The Alvin J. Siteman Cancer Center is a National Cancer Institute (NCI) designated comprehensive cancer

    E-Print Network [OSTI]

    Subramanian, Venkat

    KEY FACTS The Alvin J. Siteman Cancer Center is a National Cancer Institute (NCI) designated comprehensive cancer center, the only one in Missouri and within a 240 that would speed discoveries in the lab into actual patient care. In 2009, Siteman Cancer

  1. Genetics of Hereditary Breast and Ovarian Cancer The majority of cancer cases are not attributable to hereditary causes. However, cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    May 2013 Genetics of Hereditary Breast and Ovarian Cancer The majority of cancer cases are not attributable to hereditary causes. However, cancer can be hereditary in some families. There are many factors that can increase the probability that the cancers in a family may be hereditary. Some of these factors are

  2. Prognostic and therapeutic relevance of molecular subtypes in high-grade serous ovarian cancer.

    E-Print Network [OSTI]

    2014-01-01

    targeted therapies in ovarian cancer. Nat Rev Cancer. 2009;Brief Communication | JNCI ovarian cancer linked to clinicaldebulked patients with ovarian cancer. Cancer Res. 2008;68(

  3. A Million Cancer Genome Warehouse David Haussler

    E-Print Network [OSTI]

    McAuliffe, Jon

    Warehouse Regional Warehouses Design and Cost to Build and Operate a Million Cancer Genome Warehouse CAPEX

  4. What Lung Cancer Patients Need to Know

    E-Print Network [OSTI]

    Kaski, Samuel

    What Lung Cancer Patients Need to Know About Bone Health A Publication of The Bone and Cancer Foundation #12;Contents THIS PUBLICATION PROVIDES IMPORTANT INFORMATION ABOUT THE RELATIONSHIP BETWEEN LUNG CANCER AND BONE HEALTH. HOW BONE WORKS (PAGE 2). WHAT LUNG CANCER CAN DO TO BONE (PAGE 2). TREATING BONE

  5. Pancreatic Cancer Clinical Trials Guest Expert

    E-Print Network [OSTI]

    O'Hern, Corey S.

    about pancreatic cancer. In the United States in 2014 we are expecting to see about 45,000 cases and unfortunately, the death rate is about 40,000 deaths from pancreas cancer and although it is actually uncommon, only about 3% of all cancers diagnosed in the United States are pancreatic cancer, it is in fact

  6. AGE -A HEA Cancer FoRs

    E-Print Network [OSTI]

    Balasuriya, Sanjeeva

    CANCER CANCER R REVIEW D DR ADAM B FoRs RESEARCH DOCUMENT BUTLER, RE H COVERA T ESEARCH P AGE;Cancer FoRs 5 June 2013 Page 2 BACKGROUND This document was created for the Health and Medical Research Strategic Review and attempts to outline the coverage of cancer research throughout the university

  7. colon cancer Can genetics help tackle

    E-Print Network [OSTI]

    Rasdeaconu, Rares

    Predicting colon cancer Can genetics help tackle the second leading cancer killer? momentum without cancer. #12;EDITOR Melissa Marino CONTRIBUTING WRITERS Stephanie Crowe Leigh MacMillan Cynthia, TN 37232-2390 (615) 322-4747 Momentum is published twice a year by Vanderbilt-Ingram Cancer Center

  8. TARGETING CANCER STEM CELLS Summary of technology

    E-Print Network [OSTI]

    Mucina, Ladislav

    TARGETING CANCER STEM CELLS Summary of technology Cancerstemcells(CSCs)playasignificantroleinleukemia, glioma, and breast, lung, gastrointestinal, prostate and ovarian cancer etiology, causing therapy of a new adjunct for targeted therapy of cancer involving CSCs, for use in combination with existing cancer

  9. Contact Details Journeying Beyond Breast Cancer

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    Home About Contact Details Facebook Search Journeying Beyond Breast Cancer making sense of the cancer experience Feeds: Posts Comments Cancer-fighting fountain pen May 20, 2009 by JBBC A research team be used both as a research tool in the development of next-generation cancer treatments

  10. Breast Cancer and Genetic Testing Mari Suzuki

    E-Print Network [OSTI]

    Brutlag, Doug

    Breast Cancer and Genetic Testing Mari Suzuki BIOCHEM 118Q Professor Doug Brutlag Spring 2005 #12, which is often referred to as the breast cancer gene. My mother had fought off breast cancer and she the mutation means it's almost certain that I will develop breast cancer at some point in my life. It also

  11. Dominant Negative ATM Mutations in Breast Cancer Families

    E-Print Network [OSTI]

    Nyholt, Dale R.

    cancer fami- lies containing members with ovarian cancer or male breast cancer (1). However, mutations of female breast cancer but no cases of male breast cancer or ovarian cancer (1). It is, therefore, likelyDominant Negative ATM Mutations in Breast Cancer Families Georgia Chenevix-Trench, Amanda B

  12. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: The selenium and vitamin E cancer prevention trial (SELECT)

    E-Print Network [OSTI]

    2009-01-01

    PR, Albanes D. Selenium, vitamin E, and prostate cancer--Effect of Selenium and Vitamin E on Risk of Prostate CancerOther Cancers: The Selenium and Vitamin E Cancer Prevention

  13. Markers of chemically induced cancer

    SciTech Connect (OSTI)

    Freeman, G.; Milman, H.A. (eds.)

    1984-01-01

    This book is a concise review and evaluation of available data for recognizing and measuring markers of cancer or oncogenesis provoked in vivo by chemicals using relatively short-term experiments in animals. This review focuses on biochemical and immunological changes that correlate with carcinogenicity. Such ''markers,'' if occurring early enough, may be used to predict the onset of cancer in experimental animals exposed to potential chemical carcinogens long before morphological changes are seen. It is by examining all the information available about the potential carcinogenicity of chemicals that proper decisions can be made towards limiting the risk of cancer due to exposure to chemical carcinogens.

  14. The Cancer Genome Atlas Pan-Cancer analysis project

    E-Print Network [OSTI]

    Lander, Eric S.

    The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a ...

  15. Stromal Modulation of Radiation Carcinogenesis in Breast Cancer

    E-Print Network [OSTI]

    Nguyen, David Hiendat Hua

    2011-01-01

    receptor-negative breast cancer patients. J Clin Invest 120,Triple-Negative Breast Cancer: Distinguishing between Basaland Nonbasal Subtypes. Clin Cancer Res 15, 2302-2310. Reis-

  16. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print The cancer drug Gleevec is extremely specific, binding and inhibiting only the cancer-causing tyrosine protein...

  17. School Response to Families with Children with Cancer

    E-Print Network [OSTI]

    Nielsen, Shelley Lynn

    2010-01-01

    Coping with childhood cancer: Where do we go from here?issues in childhood cancer. School Psychology Review, 28(2),2001). Children surviving cancer: Psychosocial adjustment,

  18. Approaches to identifying synthetic lethal interactions in cancer

    E-Print Network [OSTI]

    Thompson, JM; Nguyen, QH; Singh, M; Razorenova, OV

    2015-01-01

    options in recurrent ovarian cancer: latest evidence andsensitive relapsed ovarian cancer. N Engl J Med. 2012;366:29. Agarwal R, Kaye SB. Ovarian cancer: strategies for over-

  19. Mapping Dysregulated Metabolic Pathways in Cancer Using Functional Metabolomic Platforms

    E-Print Network [OSTI]

    Benjamin, Daniel Isaac

    2015-01-01

    al. Adipocytes promote ovarian cancer metastasis and provideterm migration of human ovarian cancer cells. Cell Communand invasion of ovarian cancer cells, through direct

  20. Stromal Modulation of Radiation Carcinogenesis in Breast Cancer

    E-Print Network [OSTI]

    Nguyen, David Hiendat Hua

    2011-01-01

    2009). Triple-Negative Breast Cancer: Distinguishing betweenreceptor-negative breast cancer patients. J Clin Invest 120,sporadic basal-like breast cancer. Oncogene 26, 2126-2132.

  1. Diffusion MRI Methods for Improved Treatment Monitoring in Breast Cancer

    E-Print Network [OSTI]

    Aliu, Sheye

    2009-01-01

    Breast Cancer Overview 2.1 Breast Anatomy . . . . .2.2 Breast Cancer Demographics . . . . . . . . 2.3 Breastii References Diffusion Tensor Imaging in Breast Cancer 5.1

  2. Breast Cancer and Melanoma in the Same Pedigree

    E-Print Network [OSTI]

    Seltzer, Murray H; Leachman, Sancy A

    2008-01-01

    6 [ PubMed ] 11. The Breast Cancer Linkage Consortium. (of ocular melanoma with breast cancer but not with cutaneousin women with previous breast cancer. Journal of Clinical

  3. Serum 25-hydroxyvitamin D and risk of breast cancer

    E-Print Network [OSTI]

    Mohr, Sharif Burgette

    2012-01-01

    and prevention of breast cancer: pooled analysis. Anticancerand reduced risk of breast cancer: a population-based case-between vitamin D and breast cancer incidence and natural

  4. Cancer prevention for global health: a report from the ASPO International Cancer Prevention Interest Group.

    E-Print Network [OSTI]

    Braithwaite, Dejana; Boffetta, Paolo; Rebbeck, Timothy R; Meyskens, Frank

    2012-01-01

    Bull 14. WHO. International Agency for Research on Cancer:World Cancer Report. In Stuart BW, Kleihues P, editors.of environmental and occupational cancer. Oncogene 2004;23:

  5. Protein engineering for cancer therapy

    E-Print Network [OSTI]

    Liu, David Victor

    2012-01-01

    The immunosuppressive effects of CD4?CD25? regulatory T cells (Tregs) interfere with anti-tumor immune responses in cancer patients. In the first part of this work, we present a novel class of engineered Interleukin-2 ...

  6. Chromatin organisation in breast cancer 

    E-Print Network [OSTI]

    Rafique, Sehrish

    2013-11-29

    Epigenetic misregulation of gene expression is known to be an important feature in cancer. This has mainly been studied at the level of changes in DNA methylation and histone modifications at individual genes. In this ...

  7. Fusion genes in breast cancer

    E-Print Network [OSTI]

    Batty, Elizabeth

    2012-02-07

    Fusion genes in breast cancer Elizabeth M. Batty Clare College, University of Cambridge A dissertation submitted to the University of Cambridge in candidature for the degree of Doctor of Philosophy November 2010 ii... is the outcome of work done in collaboration except where specifically indicated in the text. It has not been submitted whole or in part for any other qualification at any other University. iii Summary Fusion genes in breast cancer Elizabeth Batty...

  8. The effect of gender on Helicobacter pylori and gastric cancer

    E-Print Network [OSTI]

    Sheh, Alexander

    2011-01-01

    Gastric cancer is the 2nd leading cause of cancer death worldwide and the 4th most commonly diagnosed cancer worldwide. Helicobacter pylori infection is the major risk factor of gastric cancer, and as such, this bacterium ...

  9. Serum 25-hydroxyvitamin D and risk of breast cancer

    E-Print Network [OSTI]

    Mohr, Sharif Burgette

    2012-01-01

    and prevention of breast cancer: pooled analysis. AnticancerBray F, Ferlay J, Pisani P. Global cancer statistics, 2002.CA-Cancer J Clin. 2005;55(2):74-108. American Cancer

  10. An analytics approach to designing clinical trials for cancer

    E-Print Network [OSTI]

    Relyea, Stephen L. (Stephen Lawrence)

    2013-01-01

    Since chemotherapy began as a treatment for cancer in the 1940s, cancer drug development has become a multi-billion dollar industry. Combination chemotherapy remains the leading treatment for advanced cancers, and cancer ...

  11. Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer

    E-Print Network [OSTI]

    Greenaway, Alan

    Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer Graeme Houston Fluoroscopy 2 #12;Treatments for Cancer Palliative ­ Relief of obstruction ­ Reduce Bleeding ­ Pain Control ­ Avoid complications Disease Modifying 4 #12;Disease Modifying Cancer Treatment In Situ Ablation

  12. Communication and Cancer Suggestions for Navigating Relationships

    E-Print Network [OSTI]

    Brent, Roger

    Communication and Cancer Suggestions for Navigating Relationships During and After Cancer Moving · Increased attention to the effect of communication · Increased awareness of communication styles · Introduction to theories about communication · Consider communication patterns in relationships · Resources

  13. Genetics and molecular biology of breast cancer

    SciTech Connect (OSTI)

    King, M.C. [California Univ., Berkeley, CA (United States); Lippman, M. [Georgetown Univ. Medical Center, Washington, DC (United States)] [comps.

    1992-12-31

    This volume contains the abstracts of oral presentations and poster sessions presented at the Cold Springs Harbor Meeting on Cancer Cells, this meeting entitled Genetics and Molecular Biology of Breast Cancer.

  14. Targeting cancer metabolism: a therapeutic window opens

    E-Print Network [OSTI]

    Vander Heiden, Matthew G.

    Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

  15. ANTI-CANCER NANOPARTICLE SYNTHESIS AND CHARACTERIZATION

    E-Print Network [OSTI]

    ANTI-CANCER NANOPARTICLE SYNTHESIS AND CHARACTERIZATION Fan Mei1 , Da-Ren Chen2 and Yin-Nan Lee1 1, (-)-epigallocatechin-3-gallate (EGCG) from Green tea, Irresa and resveratrol have been shown to exhibit cancer

  16. Lgr4 in Breast Cancer Stem Cells 

    E-Print Network [OSTI]

    Zeng, Li

    2014-12-11

    Breast cancer is the most commonly diagnosed cancer among American women. G-protein coupled receptors (GPCR) comprise a huge family protein with almost 800 members. GPCRs sense molecules or other stimuli outside the cell, and activate intracellular...

  17. Risk of Salivary Gland Cancer After Childhood Cancer: A Report From the Childhood Cancer Survivor Study

    SciTech Connect (OSTI)

    Boukheris, Houda; Stovall, Marilyn; Gilbert, Ethel S.; Stratton, Kayla L.; Smith, Susan A.; Weathers, Rita; Hammond, Sue; Mertens, Ann C.; Donaldson, Sarah S.; Armstrong, Gregory T.; Robison, Leslie L.; Neglia, Joseph P.; Inskip, Peter D.

    2013-03-01

    Purpose: To evaluate effects of radiation therapy, chemotherapy, cigarette smoking, and alcohol consumption on the risk of second primary salivary gland cancer (SGC) in the Childhood Cancer Survivor Study (CCSS). Methods and Materials: Standardized incidence ratios (SIR) and excess absolute risks (EAR) of SGC in the CCSS were calculated using incidence rates from Surveillance, Epidemiology, and End Results population-based cancer registries. Radiation dose to the salivary glands was estimated based on medical records. Poisson regression was used to assess risks with respect to radiation dose, chemotherapy, smoking, and alcohol consumption. Results: During the time period of the study, 23 cases of SGC were diagnosed among 14,135 childhood cancer survivors. The mean age at diagnosis of the first primary cancer was 8.3 years, and the mean age at SGC diagnosis was 24.8 years. The incidence of SGC was 39-fold higher in the cohort than in the general population (SIR = 39.4; 95% CI = 25.4-57.8). The EAR was 9.8 per 100,000 person-years. Risk increased linearly with radiation dose (excess relative risk = 0.36/Gy; 95% CI = 0.06-2.5) and remained elevated after 20 years. There was no significant trend of increasing risk with increasing dose of chemotherapeutic agents, pack-years of cigarette smoking, or alcohol intake. Conclusion: Although the cumulative incidence of SGC was low, childhood cancer survivors treated with radiation experienced significantly increased risk for at least 2 decades after exposure, and risk was positively associated with radiation dose. Results underscore the importance of long-term follow up of childhood cancer survivors for the development of new malignancies.

  18. Identifying Risk Groups Associated with Colorectal Cancer

    E-Print Network [OSTI]

    Jin, Huidong "Warren"

    Identifying Risk Groups Associated with Colorectal Cancer Jie Chen1 , Hongxing He1 , Huidong Jin1 of identifying and describing risk groups for colorectal cancer (CRC) from population based administrative health are applied to the colorectal cancer patients' profiles in contrast to background pa- tients' profiles

  19. www.yalecancercenter.org Lung Cancer Screening

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Lung Cancer Screening Guest Experts: Lynn Tanoue, MD Professor of Therapeutic Radiology and an expert in the use of radiation to treat lung cancers and cutaneous lymphomas Oncology Program. Dr. Detterbeck and I also co- direct the new Yale Lung Cancer and Lung Nodule Screening

  20. www.yalecancercenter.org Lung Cancer Awareness

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Lung Cancer Awareness Month Update Guest Expert: Frank Detterbeck, MD take a look at the prevention and treatment of lung cancer with Dr. Frank Detterbeck, Professor I want to start out with a question about cigarette smoking and lung cancer. Obviously

  1. www.yalecancercenter.org Lung Cancer Awareness

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Lung Cancer Awareness Month Update 2008 Guest Expert: Frank Detterbeck, MD reach the end of lung cancer awareness month, Ed and Ken welcome the Directors of the Yale Cancer Center of thoracic surgery at Yale and Dr. Tanoue is a Professor of pulmonary medicine. Tanoue Unfortunately, lung

  2. www.yalecancercenter.org Understanding Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Understanding Lung Cancer Guest Expert: Daniel Morgensztern, MD www of radiation to treat lung cancer and cutaneous lymphomas. If you would like to join the conversation, you can at the Yale School of Medicine and he specializes in the treatment and care of patients with lung cancer. Here

  3. Birgit Arb, MD Cape Fear Cancer

    E-Print Network [OSTI]

    Olszewski Jr., Edward A.

    Birgit Arb, MD Cape Fear Cancer Specialists Women of Hope is a charitable organization dedicated to enhancing the quality of life for the female cancer patient, their families, and friends. They provide through any type of cancer from diagnosis through survivorship. Women of Hope 1642 South 41st Street

  4. Breast Cancer Research Finding Answers. Finding Cures.

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Breast Cancer Research Finding Answers. Finding Cures. Thanks to improvements in treatment and early detection, more and more women are surviving breast cancer. In fact, the five-year survival rate for women with breast cancer today is 90%, up from only 63% in the 1960s. While progress has clearly been

  5. LITERATURE REVIEW Autism and Cancer Risk

    E-Print Network [OSTI]

    Crespi, Bernard J.

    LITERATURE REVIEW Autism and Cancer Risk B. Crespi A literature review was conducted on the genetic and developmental bases of autism in relation to genes and pathways associated with cancer risk. Convergent lines cancer-associated genes and pathways, and (4) contrasts with schizophrenia, Parkinson's, and Alzheimer

  6. Breast Cancer Awareness Day October 7, 2009

    E-Print Network [OSTI]

    Kihara, Daisuke

    Breast Cancer Awareness Day October 7, 2009 All are welcome to the different events organized by the Purdue Breast Cancer Discovery Group. Sigma Xi Distinguished Lecture "Genes and the microenvironment: the two faces of breast cancer" Deans Auditorium (PFEN241) Pfendler Hall ­ Purdue University 12

  7. This issue of the Stanford Cancer Institute Clinical Research Newsletter is focused on our multi-disciplinary Women's Cancer and Urologic Cancer Programs.

    E-Print Network [OSTI]

    Puglisi, Joseph

    This issue of the Stanford Cancer Institute Clinical Research Newsletter is focused on our multi-disciplinary Women's Cancer and Urologic Cancer Programs. Both programs provide comprehensive cancer services, employ, including targeted therapies and vaccines. The new Stanford Women's Cancer Center opened on June 27, 2011

  8. SKIN CANCER INSTITUTE THE CANCER INSTITUTES AT NORTHWESTERN MEDICINE

    E-Print Network [OSTI]

    Chisholm, Rex L.

    of specimens with unclear diagnoses sent from throughout the United States. Our pathologists are thus some than 75 percent of skin cancer deaths. It is now estimated that one in every 55 people will be diagnosed with melanoma. The incidence also is rising at a rate faster than that of the seven most common

  9. Colorectal Cancer Video for the Deaf Community: A Randomized Control Trial

    E-Print Network [OSTI]

    Shabaik, Salma; LaHousse, Sheila F.; Branz, Patricia; Gandhi, Visha; Khan, Amir M.; Sadler, Georgia Robins

    2010-01-01

    cantly more colorectal cancer knowledge than the controlthe Deaf community about colorectal cancer. KeywordsASL . Cancer prevention . Colorectal cancer . Deaf .

  10. The path to personalized medicine in women?s cancers: challenges and recent advances

    E-Print Network [OSTI]

    Konecny, GE

    2015-01-01

    staging system for ovarian cancer: what is new in comparisontarget tumor vasculature in ovarian cancer. Curr Opin Obstetbreast cancer and ovarian cancer therapy. Curr Opin Obstet

  11. The path to personalized medicine in women cancers: Challenges and recent advances

    E-Print Network [OSTI]

    Konecny, GE

    2015-01-01

    staging system for ovarian cancer: what is new in comparisontarget tumor vasculature in ovarian cancer. Curr Opin Obstetbreast cancer and ovarian cancer therapy. Curr Opin Obstet

  12. Chemotherapy of ovarian cancer directed by the human tumor stem cell assay.

    E-Print Network [OSTI]

    1981-01-01

    RC (1975) Chemotherapy of ovarian cancer: Past and present.treatment of advanced ovarian cancer. Cancer Treat Rep 63:for predicting response of ovarian cancer to chemotherapy.

  13. Tax Credits, Rebates & Savings | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    Hutchinson Utilities Commission- Commercial Energy Efficiency Program Hutchinson Utilities Commission (HUC) offers rebates to commercial customers in Hutchinson who perform energy...

  14. DIESEL et CANCER Dominique Lafon

    E-Print Network [OSTI]

    Boyer, Edmond

    1/5 DIESEL et CANCER Dominique Lafon INERIS (*) De nombreuses questions se posent sur la toxicité des émissions des moteurs diesel. C'est un sujet qui a beaucoup préoccupé les scientifiques ces EMISSIONS DU DIESEL. Avant d'aborder la toxicité des émissions du diesel, un rappel de leur composition est

  15. Do Cell Phones Cause Cancer?

    E-Print Network [OSTI]

    Leikind, Bernard

    2010-01-01

    Do cell phones, household electrical power wiring or appliance, or high voltage power lines cause cancer? Fuggedaboudit! No way! When pigs fly! When I'm the Pope! Don't text while you're driving, however, or eat your cell phone. All organisms absorb microwave radiation directly as thermal energy. In living organisms, the organisms' thermal control systems, including the blood flow, and various cooling mechanisms, such as sweating in humans, that work to maintain a stable body temperature rapidly transfer the absorbed energy to the environment. Any temperature rise is small or even unobserved. Any proposed mechanism by which cell phone radiation might cause cancer must begin with this fact. But the amount of radiation absorbed from a cell phone is less than that produced by normal metabolic processes, and much less than that produced by, for example, exercise. None of these normal metabolic processes cause cancer. Therefore, the much smaller amounts of energy from cell phones doesn't cause cancer either. All f...

  16. Pancreatic cancer: Pathogenesis, prevention and treatment

    SciTech Connect (OSTI)

    Sarkar, Fazlul H. Banerjee, Sanjeev; Li, Yiwei

    2007-11-01

    Pancreatic cancer is the fourth leading cause of cancer death in the United States with a very low survival rate of 5 years. To better design new preventive and/or therapeutic strategies for the fight against pancreatic cancer, the knowledge of the pathogenesis of pancreatic cancer at the molecular level is very important. It has been known that the development and the progression of pancreatic cancer are caused by the activation of oncogenes, the inactivation of tumor suppressor genes, and the deregulation of many signaling pathways among which the EGFR, Akt, and NF-{kappa}B pathways appear to be most relevant. Therefore, the strategies targeting EGFR, Akt, NF-{kappa}B, and their downstream signaling could be promising for the prevention and/or treatment of pancreatic cancer. In this brief review, we will summarize the current knowledge regarding the pathogenesis, prevention, and treatment of pancreatic cancer.

  17. Predictive and therapeutic markers in ovarian cancer

    DOE Patents [OSTI]

    Gray, Joe W.; Guan, Yinghui; Kuo, Wen-Lin; Fridlyand, Jane; Mills, Gordon B.

    2013-03-26

    Cancer markers may be developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genes in the human chromosomal regions, 8q24, 11q13, 20q11-q13, were found to be amplified indicating in vivo drug resistance in diseases such as ovarian cancer. Diagnosis and assessment of amplification levels certain genes shown to be amplified, including PVT1, can be useful in prediction of poor outcome of patient's response and drug resistance in ovarian cancer patients with low survival rates. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copy number and/or gene expression are associated with reduced survival duration in certain diseases and cancers, specifically ovarian cancer. Therapeutics to inhibit amplification and inhibitors of one of these genes, PVT1, target drug resistance in ovarian cancer patients with low survival rates is described.

  18. Facility Request Form H. Fred Simons African American Cultural Center

    E-Print Network [OSTI]

    Alpay, S. Pamir

    Requested? Yes No Setup Request: Chairs Podium Microphone Round Tables Special Requirements This event has-3180 Phone: (860) 486-3433 Fax (860) 486-1193 Square Tables Page 1 Print Form #12;AACC Facility Usage. Advisor Address Advisor Email Signature Approval Disapproval Date Date Dr. Willena K. Price, Director Page

  19. FRED E. WOOD Chancellor, University of Minnesota Crookston

    E-Print Network [OSTI]

    Minnesota, University of

    -2007 Associate Dean, College of Letters and Science, UC Davis, 1991-2004 Chair, Department of Geography, UC Davis. Responsible for setting the direction and the strategic vision for the campus. Report directly to the President of the University of Minnesota and serve on the Senior Leadership Council. Work with the Board

  20. United States Department of the Interior, Fred A , Seaton, Se.

    E-Print Network [OSTI]

    . Red mouth disease in rainbow trout. !! Headquarters: Eastern Fish Disease Lab" Leetown (PSUL' In and around the rT ,.. ,:rtl r" ,.", #12;be inflamed and even eroded as in the" red mouth" disease in rainbow producing deep necrotic cra- ters lined with red or grayish muscle tissue. In some instances these lesions

  1. Fred S. Roberts Command, Control, and Interoperability Center

    E-Print Network [OSTI]

    Vulnerabilities? 9 #12;· Car hacking: criminals remotely take control of your car · Imagine the damage a hacker could do in a stadium parking lot. Another Scenario: Car Hacking in the Stadium Parking Lot 10 Credit: ctvnews.ca #12;· Car hacking: criminals remotely take control of your car · A serious challenge as in

  2. Data Clustering Using Evidence Accumulation Ana L.N. Fred

    E-Print Network [OSTI]

    number of compact clusters; the K-means algorithm performs this decomposition, with several clusterings addressed in areas like sensor fusion and supervised learning techniques in pattern recognition - known into a large number of compact and small clus- ters; different decompositions are obtained by random ini

  3. Emergency Response Plan for the Fred Kaiser and Macleod Buildings

    E-Print Network [OSTI]

    Pulfrey, David L.

    with Disabilities - Locations ..............................................10 6 Responsibilities In the Case of Hazardous Material Releases, Spills, Explosions or Fires..27 Building Occupants - Instructions................................................................27 9.1 Explosion or Fire due to Hazardous Materials .........................................27 9

  4. Emergency Response Plan for the Fred Kaiser and Macleod Buildings

    E-Print Network [OSTI]

    Pulfrey, David L.

    Wardens 8 5 Occupants with Disabilities - Locations 10 6 Responsibilities 11 6.1 Building Emergency In the Case of an Earthquake 20 9 In the Case of Hazardous Material Releases, Spills, Explosions or Fires 27 9.1 Explosion or Fire due to Hazardous Materials 27 9.2 Gas Leaks 28 9.3 Chemical, Biohazard, or Radiation

  5. Experience Curves and Solar PV Fred Heutte, Senior Policy Associate

    E-Print Network [OSTI]

    resources costs as being ranges rather than fixed values. It is evident that the question of future solar PV for transmission expansion. Consequently, the future estimated cost projection for solar PV has been a point for solar PV should be dramatically changed "downward" going forward (i.e., significantly less of a cost

  6. Modeling Task Systems Using Parameterized Partial Orders Fred Houben

    E-Print Network [OSTI]

    Vaandrager, Frits

    , and that there exists a hierarchical relationship between tasks. For instance, a manufacturing order of a beer brewery

  7. Affective Interactive Narrative in the CALLAS Project Fred Charles1

    E-Print Network [OSTI]

    Pelachaud, Catherine

    Vogt2 , Nikolaus Bee2 , Maurizio Mancini3 , Jérôme Urbain4 , Marc Price5 , Elisabeth André2 , Catherine.lemercier, m.o.cavazza}@tees.ac.uk 2 Multimedia Concepts and Applications Group, Augsburg University, Germany.mancini, c.pelachaud}@iut-univ.paris8.fr 4 Faculté Polytechnique de Mons, Department of Electrical

  8. Fred S. Roberts Command, Control, and Interoperability Center

    E-Print Network [OSTI]

    be commandeered by an outside source Example: Drones over Stadiums 12 Source: UT Austin Aerospace Engineering #12

  9. Mr. Fred Steinkuehler Granite City Steel Division National Steel Corporation

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity of NaturalDukeWakefield Municipal Gas &SCE-SessionsSouthReport for the Weldon Spring,7=cr5rnP 7694 i+lJ , I-1 1&q

  10. Mr. Fred Cartwright Executive Director, Clemson University International Center

    Office of Energy Efficiency and Renewable Energy (EERE) Indexed Site

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on Delicious RankADVANCED MANUFACTURING OFFICESpecialAPPENDIX F WetlandsofOpen-AccessMotor SystemsMr. Chairman

  11. FRED - Q & A | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LISTStar2-0057-EA Jump to:ofEnia SpA JumpGmbH EFCFBA Franco BrasileiraFONSI

  12. OpenEI Community - FRED+free energy database

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIXsourceII Jump to:InformationInformationOorjaen The EnergyInvitationFOA aimedTeam!

  13. Introducing FRED, Enabling Unique Visualization and Manipulation of Energy

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page on Google Bookmark EERE: Alternative Fuels Data Center Home Page on QA:QA J-E-1 SECTION J APPENDIX E LIST OFAMERICA'SHeavyAgency (IRENA) Jump to: navigation, searchData at Multiple Scales

  14. Anti-cancer Technology Summary 121 Research Drive, Suite 501

    E-Print Network [OSTI]

    Peak, Derek

    Anti-cancer Technology Summary 121 Research Drive, Suite 501 Saskatoon, SK, S7N 1K2 Tel: (306) 966 cancers are ranked 2ed , 3ed and 11th of the most diagnosed cancers (National Cancer Institute, USA cancer cells but also healthy ones. A great opportunity exists for targeted therapies for the use solely

  15. Cancer Research in Botswana Surbhi Grover, MD MPH

    E-Print Network [OSTI]

    Bushman, Frederic

    Cancer Research in Botswana Surbhi Grover, MD MPH Assistant Professor, Radiation Oncology, UPENN and are developing cancers and other NCDs #12;3 HIV and Cancer wHIV infection increases the risk of cancer wIn the later stages of HIV infection, chronic immunosuppression (& other co-factors) leads to cancer formation

  16. PrincetonUniversity In-Vitro Studies of Cancer

    E-Print Network [OSTI]

    Petta, Jason

    PrincetonUniversity In-Vitro Studies of Cancer Cell Death Due to Hyperthermia C. Barkey1, RUniversity Cancer: Facts and Figures World Wide 10.1 million newly diagnoses/year with ~10% increase 6.2 million deaths are attributed to cancer and its complication each year American Cancer Society 2007 and Le Cancer

  17. Selective pressures for and against genetic instability in cancer

    E-Print Network [OSTI]

    Wan, Frederic Yui-Ming

    Selective pressures for and against genetic instability in cancer: a time-dependent problem Natalia instability in cancer is a two-edge sword. It can both increase the rate of cancer progression (by increasing the probability of cancerous mutations) and decrease the rate of cancer growth (by imposing a large death toll

  18. High Throughput Analysis of Breast Cancer Specimens on the Grid

    E-Print Network [OSTI]

    cancer accounts for about 30% of all cancers and 15% of all cancer deaths in women in the United States in the United States. Women living in North America have the highest rate of breast cancer in the world [1]. In spite of the increase in the incidence of the disease, the death rates of breast cancer continue

  19. Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam

    E-Print Network [OSTI]

    Petta, Jason

    Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam PresentedPresentation Overview What is Synthetic Biology?What is Synthetic Biology? ProjectProject Cancer: Detect and DestroyCancer regeneration Diabetes Cancer therapy Artificial immune system Environmental Biosensing Environmental

  20. Global modeling of cancer gene expression signa-Cancer leads to permanent changes in cell's physiological state and various

    E-Print Network [OSTI]

    Kaski, Samuel

    Global modeling of cancer gene expression signa- tures Cancer leads to permanent changes in cell cancer types. Less is known about the underlying biological processes, or relationships between different cancer types with respect to these changes. While each specific cancer type has a set of unique

  1. Genome Science and Personalized Cancer Treatment

    ScienceCinema (OSTI)

    Gray, Joe

    2010-01-08

    August 4, 2009 Berkeley Lab lecture: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

  2. Genome Science and Personalized Cancer Treatment

    SciTech Connect (OSTI)

    Gray, Joe

    2009-08-07

    August 4, 2009 Berkeley Lab lecture: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks — particularly with regard to breast cancer.

  3. Genome Science and Personalized Cancer Treatment

    SciTech Connect (OSTI)

    Gray, Joe

    2009-08-04

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks — particularly with regard to breast cancer.

  4. Perspectives on the mesenchymal origin of metastatic cancer

    E-Print Network [OSTI]

    Huysentruyt, Leanne C.; Seyfried, Thomas N.

    2010-01-01

    of metastasis. Nature Reviews Cancer, 9(4), 239–252. 12.M. , & Kovarik, J. (1987). Is cancer a macrophage- mediatedof secondary growths in cancer of the breast. Lancet, 1,

  5. Nanomaterials for the detection of cancer-associated biomarkers

    E-Print Network [OSTI]

    Mu, Chunyao Jenny

    2010-01-01

    Prostate cancer persists as a major public health issue in the United States and remains the second leading cause of cancer death in men. Early detection and disease monitoring in prostate cancer can significantly improve ...

  6. Microwave imaging for ultra-wideband antenna based cancer detection 

    E-Print Network [OSTI]

    Zhang, Haoyu

    2015-06-29

    Breast cancer is one of the most widespread types of cancer in the world. The key factor in treatment is to reliably diagnose the cancer in the early stages. Moreover, currently used clinical diagnostic methods, such as ...

  7. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism Print Tuesday, 23 June 2015 13:00 The cancer drug...

  8. The genomic complexity of primary human prostate cancer

    E-Print Network [OSTI]

    Carter, Scott L.

    Prostate cancer is the second most common cause of male cancer deaths in the United States. However, the full range of prostate cancer genomic alterations is incompletely characterized. Here we present the complete sequence ...

  9. Analysis of Assembly Bill 547: Ovarian Cancer Screening

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2004-01-01

    al. (1999). Screening for ovarian cancer: a pilot randomizedLung, Colorectal & Ovarian Cancer Screening Trial ( P L CA Snapshot of Ovarian Cancer. http://prg.nci.nih.gov/

  10. Cell Motility and Deformability in the Pathogenesis of Lung Cancer

    E-Print Network [OSTI]

    Pagano, Paul Carmelo

    2015-01-01

    metastatic potential of ovarian cancer cells. PLoS One 2012;cisplatin resistance in ovarian cancer cells. Nanomedicine :metastatic potential of ovarian cancer cells. PLoS One 2012;

  11. Cutaneous cancers in Calabar, Southern Nigeria

    E-Print Network [OSTI]

    Asuquo, Maurice E; Ebughe, Godwin

    2009-01-01

    Skin cancer in Zaria, Nigeria. Trop Doct 1995; 25(Suppl. ):Malignancies in Kano, Northern Nigeria: A histopathologicalequatorial rain forest of Nigeria. International Journal of

  12. Cancer survivorship research: the challenge of recruiting adult long term cancer survivors from a cooperative clinical trials group

    E-Print Network [OSTI]

    2009-01-01

    quality of life among long-term survivors of breast cancer.Breast Cancer Res Treat. 1996;39(3):261–73. doi:B, Bower JE. Breast Cancer in Younger Women: Reproductive

  13. Polymorphisms in Stromal Genes and Susceptibility to Serous Epithelial Ovarian Cancer: A Report from the Ovarian Cancer Association Consortium

    E-Print Network [OSTI]

    2011-01-01

    and serous epithelial ovarian cancer stratified by case PLoSLumican SNPs and Serous Ovarian Cancer References 1. JemalEpidemiology and etiology of ovarian cancer. Semin Oncol 18:

  14. Breast cancer is a common form of cancer among women. Mammography is used for early detection, but it cannot detect all instances of cancer. New magnetic resonance imaging

    E-Print Network [OSTI]

    Subramanian, Kalpathi R.

    1 Breast cancer is a common form of cancer among women. Mammography is used for early detection by Stanford University and used at Presbyterian Hospital have detected breast cancer where mammography has possible to render MR data in 3D at interactive rates. This paper presents the design of breast cancer

  15. Nanotechnology in Cancer Treatment and Detection Richard Acosta

    E-Print Network [OSTI]

    Fygenson, Deborah Kuchnir

    Nanotechnology in Cancer Treatment and Detection Richard Acosta #12;Motivation ·Ineffectiveness or roughly 100 times smaller than most human cells Cancer Nanotechnology research is interdisciplinary

  16. Los Alamos researcher pens prizewinning essay on cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Researcher pens prizewinning essay on cancer Los Alamos researcher pens prizewinning essay on cancer Ludmil Alexandrov made strong points this week in the journal Science winning a...

  17. Designer Proteins Target Epstein-Barr-Virus-Associated Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Designer Proteins Target Epstein-Barr-Virus-Associated Cancer Designer Proteins Target Epstein-Barr-Virus-Associated Cancer Print Wednesday, 03 December 2014 00:00 Immortality is...

  18. Isotope production facility produces cancer-fighting actinium

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer therapy gets a boost from new isotope Isotope production facility produces cancer-fighting actinium A new medical isotope project shows promise for rapidly producing major...

  19. Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer

    E-Print Network [OSTI]

    Hammock, Bruce D.

    Review Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer Cancer Center, University of California, Davis, CA 95616, United States b Department of Food Science

  20. The Viability of Cancerous vs. Non-cancerous Cells

    E-Print Network [OSTI]

    Nickels, Logan

    2009-10-01

    is to use a cell-based assay to inject the compounds into the cells, and then measure the cells’ growth. To find the effects the compounds had on the cells, we needed some way to visualize the viability of the cell lines. To do this, we used... before the actual assay was a toxicity screen. The compounds used in the screen were stored in 384-well polypropylene plates. The plates contained 20 µl of compound Figure 2. This graph shows the growth curve of the cancerous A-549 cells, which have...

  1. Early Growth Response 3 (Egr3) Is Highly Over-Expressed in Non-Relapsing Prostate Cancer but Not in Relapsing Prostate Cancer

    E-Print Network [OSTI]

    Pio, Rebecca; Jia, Zhenyu; Baron, Veronique T; Mercola, Dan; Agoulnik, Irina U

    2013-01-01

    company developing prostate cancer related tests. Dr. Barontherapy for prostate cancer. There are no marketed productsand prognosis of prostate cancer. September 2011: US

  2. Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)

    E-Print Network [OSTI]

    2012-01-01

    Familial Breast and Ovarian Cancer and Center of IntegratedAustralia, 66 Australian Ovarian Cancer Study [AOCS], PeterHereditary Breast & Ovarian Cancer (GC-HBOC) was supported

  3. Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility â??Hot-Spotâ?

    E-Print Network [OSTI]

    2010-01-01

    and susceptibility to serous ovarian cancer in three studygenetic risk associations for ovarian cancer throughthe international Ovarian Cancer Association Consortium. Br

  4. Development of a Breast Cancer Stem Cell Model and the Inhibitory Regulation of Small Molecule Phytochemicals on Various Stages of Human Breast Cancer Cells

    E-Print Network [OSTI]

    Tin, Antony Shen

    2013-01-01

    stem   cells   in   breast   cancer   and   metastasis.  Breast  cancer  research  and  treatment  118(2):241-­?Birnbaum  D  (2009)  Breast  cancer  stem  cells:  tools  

  5. Bacon butty cancer risk ONLINE REPORTER

    E-Print Network [OSTI]

    Lega, Joceline

    Bacon butty cancer risk ONLINE REPORTER Published: 31st October 2007 0 PROCESSED meats, including ham and bacon are such a high risk factor for bowel cancer they should be avoided completely, bacon, pastrami, salami, and frankfurters. However, not all minced meats and hamburgers were considered

  6. Cancer Stem Cells: Models and Concepts

    E-Print Network [OSTI]

    Brutlag, Doug

    Cancer Stem Cells: Models and Concepts Piero Dalerba, Robert W. Cho, and Michael F. Clarke Stanford c 2007 by Annual Reviews. All rights reserved 0066-4219/07/0218-0267$20.00 Key Words self-renewal by a pathologi- cal counterpart of normal adult stem cells, cancer stem cells. This model, first developed

  7. Diet and Cancer Are Cooked Meats Involved

    ScienceCinema (OSTI)

    LLNL - University of California Television

    2009-09-01

    Diet has been associated with differences in cancer rates in human populations for many years. Mark Knize presents the latest research on cancer causes including work performed at Lawrence Livermore National Laboratory investigating some interesting chemical products created when meat is cooked and how to reduce them. Series: Science on Saturday [10/2006] [Health and Medicine] [Science] [Show ID: 11542

  8. Clinical and experimental pathology of lung cancer

    SciTech Connect (OSTI)

    McVie, J.G.; Bakker, W.; Wagenaar, S.C.; Carney, D.

    1986-01-01

    This book contains 17 selections. Some of the titles are: Flow cytometric DNA analysis in the study of small cell carcinoma of the lung; Mechanisms of oncogenesis; Adhesion mechanisms in liver metastasis; Current concepts in the therapy of small cell lung cancer; Application of monoclonal antibodies in imaging and therapy; and Clinical applications of the biologic properties of small cell lung cancer.

  9. Restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, Mina J. (Berkeley, CA); Weaver, Valerie M. (Oakland, CA)

    1998-01-01

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

  10. Restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, M.J.; Weaver, V.M.

    1998-12-08

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying {beta}{sub 1} integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive. 14 figs.

  11. How much do cancer-related symptoms contribute to health-related quality of life in lung and colorectal cancer patients? A report from the Cancer Care Outcomes Research and Surveillance (CanCORS) Consortium.

    E-Print Network [OSTI]

    2015-01-01

    Cancer Society’s studies of cancer survivors. Can- cer.palliative care provider. Cancer J. 2013;19: 31. Catalanoof par- ticipants in the Cancer Care Outcomes Research and

  12. Identification of Genomic Predictors of Response to the CDK4/6 Inhibitor Palbociclib using the UCLATORL Panel of Human Cancer Cell Lines

    E-Print Network [OSTI]

    Conklin, Dylan Francis

    2013-01-01

    invasive epithelial ovarian cancer. Cancer treatment reviewsto breast and ovarian cancer. European journal of cancer 42,locus in advanced human ovarian-cancer. Int J Oncol 6, 129-

  13. Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: Results from three US population-based case-control studies of ovarian cancer

    SciTech Connect (OSTI)

    Whittemore, A.S.; Gong, G.; Itnyre, J.

    1997-03-01

    We investigate the familial risks of cancers of the breast and ovary, using data pooled from three population-based case-control studies of ovarian cancer that were conducted in the United States. We base estimates of the frequency of mutations of BRCA1 (and possibly other genes) on the reported occurrence of breast cancer and ovarian cancer in the mothers and sisters of 922 women with incident ovarian cancer (cases) and in 922 women with no history of ovarian cancer (controls). Segregation analysis and goodness-of-fit testing of genetic models suggest that rare mutations (frequency .0014; 95% confidence interval .0002-.011) account for all the observed aggregation of breast cancer and ovarian cancer in these families. The estimated risk of breast cancer by age 80 years is 73.5% in mutation carriers and 6.8% in noncarriers. The corresponding estimates for ovarian cancer are 27.8% in carriers and 1.8% in noncarriers. For cancer risk in carriers, these estimates are lower than those obtained from families selected for high cancer prevalence. The estimated proportion of all U.S. cancer diagnoses, by age 80 years, that are due to germ-line BRCA1 mutations is 3.0% for breast cancer and 4.4% for ovarian cancer. Aggregation of breast cancer and ovarian cancer was less evident in the families of 169 cases with borderline ovarian cancers than in the families of cases with invasive cancers. Familial aggregation did not differ by the ethnicity of the probands, although the number of non-White and Hispanic cases (N = 99) was sparse. 14 refs., 3 figs., 6 tabs.

  14. The Role of the Tumor Microenvironment and Epithelial-Mesenchymal Plasticity in Prostate Cancer Progression and Metastasis

    E-Print Network [OSTI]

    Ruscetti, Marcus Andrew

    2015-01-01

    in patients with castration-resistant prostate cancer.Cancer chemotherapy and pharmacology. 2010;66:181-9.in metastatic breast cancer. British journal of cancer.

  15. Polymorphisms of the Hypoxia Inducible Factor 1 and microRNA Related Genes and the Susceptibility and Survival of Lung Cancer and Upper Aero-Digestive Tract Cancers

    E-Print Network [OSTI]

    YANG, YING

    2014-01-01

    1 I. Lung and upper aero-digestive tractof Lung Cancer and Upper Aero-Digestive Tract Cancers Aof Lung Cancer and Upper Aero-Digestive Tract Cancers by

  16. Predicting Cancer-Specific Vulnerability via Data-Driven

    E-Print Network [OSTI]

    Ruppin, Eytan

    Resource Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic LethalityCancer Research UK, The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, Scotland the inhibition of each single gene is not. It can be harnessed to selectively treat cancer by identifying

  17. www.yalecancercenter.org Lung Cancer Awareness 2009

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Lung Cancer Awareness 2009 Guest Expert: Thomas Lynch, Jr., MD Director of lung cancer. Chu What got you interested in focusing your career on the treatment of lung cancer? Lynch I actually got into lung cancer sort of by serendipity. I wish I could tell you that it was a well

  18. Study for Advanced Lung Cancer Patients Guest Expert

    E-Print Network [OSTI]

    O'Hern, Corey S.

    Study for Advanced Lung Cancer Patients Guest Expert: Roy S. Herbst, MD, PhD Ensign Professor message at 888-234-4YCC. This week you will hear a conversation about clinical trials for advanced lung of lung caner at Yale Cancer Center and Smilow Cancer Hospital? Herbst As you probably know, lung cancer

  19. www.yalecancercenter.org An Update on Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org An Update on Lung Cancer Guest Expert: Roy Decker, MD, PhD Assistant the detection and treatment of lung cancer with Dr. Scott Gettinger and Dr. Roy Decker. Chu Scott, let us start off by telling our listeners what lung cancer is and how common it is. Gettinger Lung cancer

  20. AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention

    E-Print Network [OSTI]

    Kaski, Samuel

    AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention What are the chances that I will develop lung cancer? The #1 cause of lung cancer is exposure to tobacco smoke. Your chances increase others (second-hand smoke), the greater your chances of developing lung cancer. People who have never

  1. Cancer and the Golub Paper BINF702 WEEK 1 1

    E-Print Network [OSTI]

    Solka, Jeff

    1/2/2015 1 Cancer and the Golub Paper BINF702 WEEK 1 1 Cancer · Known medically as a malignant uncontrollably, forming a tumor · Not all tumors are cancerous; benign tumors do not invade neighboring tissues is the spread of a malignant cancer to more distant parts of the body through the lymphatic system

  2. Cancer Prevention in Eastern North Carolina Task 3: Final Report

    E-Print Network [OSTI]

    Gopalakrishnan, K.

    1 Cancer Prevention in Eastern North Carolina Task 3: Final Report A Cancer Profile of Eastern, MPA Interim Manager, NC Comprehensive Cancer Program North Carolina Department of Health and Human University Greenville, NC 27834 Contract # 02776-12 #12;2 Project Title: Cancer Prevention in Eastern North

  3. When life hurts, writing can help... Writing Through Cancer

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    When life hurts, writing can help... Writing Through Cancer An expressive writing program for people living with cancer Led by Sharon Bray, Ed.D. NEW SERIES BEGINS FRIDAY, FEBRUARY 13, 2015 10 weeks of other cancer patients and survivors. We meet each week to explore and share our stories of the cancer

  4. Cancer Cells DOI: 10.1002/anie.201103189

    E-Print Network [OSTI]

    Zhang, Liangfang

    Cancer Cells DOI: 10.1002/anie.201103189 Self-Propelled Microrockets to Capture and Isolate Circulating Tumor Cells Weiwei Gao and Omid C. Farokhzad* cancer · micromachines · nanorobots · nanotechnology metastatic cancer.[1] Since then cancer research has proved the critical roles played by CTC

  5. Eighth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer

    E-Print Network [OSTI]

    Ronquist, Fredrik

    Eighth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer Supplement to Cancer- therapy of Cancer, Princeton, New Jersey, October 12­14, 2000. Supported by grant no. 1387 from the Swedish Cancer Research Council; the Lions Foundation in Umeå, Sweden; the University of Umeå, Sweden

  6. Buccal Spectral Markers for Lung Cancer Risk Stratification

    E-Print Network [OSTI]

    Hartline, Jason D.

    Buccal Spectral Markers for Lung Cancer Risk Stratification Andrew J. Radosevich1 *, Nikhil N, United States of America Abstract Lung cancer remains the leading cause of cancer deaths in the US with .150,000 deaths per year. In order to more effectively reduce lung cancer mortality, more sophisticated

  7. Using Near-Infrared Light To Detect Breast Cancer

    E-Print Network [OSTI]

    Fantini, Sergio

    Using Near-Infrared Light To Detect Breast Cancer Using Near-Infrared Light To Detect Breast Cancer News 25 T he idea of using light to non- invasively detect breast cancer has been revisited in the past of selectively labeling breast tumors may open new opportunities in the optical detection of breast cancer

  8. Breast Cancer: Modelling and Detection D.J. GAVAGHANa

    E-Print Network [OSTI]

    Maini, Philip K.

    Breast Cancer: Modelling and Detection D.J. GAVAGHANa , J.M. BRADYb , C.P. BEHRENBRUCHb , R cancer, breast carcinoma, to illustrate how the modelling can be used in aiding detection. We to meet some of the major challenges in cancer detection. Keywords: Breast cancer; Tumour; Image

  9. Estrogen receptor prevents p53-dependent apoptosis in breast cancer

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    Estrogen receptor prevents p53-dependent apoptosis in breast cancer Shannon T. Baileya,b,c,1) More than two-thirds of breast cancers express the estrogen receptor (ER) and depend on estrogen in the treatment of ER+ breast cancers of all stages. In contrast to ER- breast cancers, which frequently harbor

  10. Breast Cancer Research and ISSN 0167-6806

    E-Print Network [OSTI]

    1 23 Breast Cancer Research and Treatment ISSN 0167-6806 Breast Cancer Res Treat DOI 10.1007/s10549-012-2266-3 Cognitive function and breast cancer: promise and potential insights from functional brain imaging Patricia function and breast cancer: promise and potential insights from functional brain imaging Patricia A. Reuter

  11. On the Performance of State Estimation for Visual Servo Systems Brad Bishop Seth Hutchinson Mark Spong

    E-Print Network [OSTI]

    Hutchinson, Seth

    Spong Coordinated Science Lab Elect. and Comp. Eng. Coordinated Science Lab University of Illinois University of Illinois University of Illinois Urbana, IL 61801 Urbana, IL 61801 Urbana, IL 61801 Abstract between the image formation process and state estimation. To this end, in this paper we present a detailed

  12. !"#adamosLoizou $ alanMedlar % darrenBishop $ andrewHutchinson $ yukChan &"'(

    E-Print Network [OSTI]

    Karp, Brad

    -Regulating Algorithm for Code Propagation and Maintenance in Wireless Sensor Networks #12;trickle What is the problem effort Need Low Maintenance Rapid Propagation Scalability Transmission Expensive ! Metadata not Code ! How often? >>#, small, resource constrained nodes Long, remote, unattended operation RequirementsChallengesSensor

  13. A sintering model for thermal barrier coatings R.G. Hutchinson a

    E-Print Network [OSTI]

    Fleck, Norman A.

    a Cambridge University Engineering Department, Trumpington Street, Cambridge CB2 1PZ, UK b Department of Engineering, Leicester University, Leicester LE1 7RH, UK Received 15 September 2005; received in revised form-PVD coatings comprise a 100­200 lm thick layer of columnar yttria-stabilised zirconia (typically, 7YSZ

  14. Prof. Ian H. Hutchinson Professor of Nuclear Science and Engineering, MIT.

    E-Print Network [OSTI]

    Chen, Sow-Hsin

    ) is Professor of Nuclear Science and Engineering at the Massachusetts Institute of Technology. His primary configuration, the Reversed Field Pinch, with the U.K. Atomic En- ergy Authority, where he made landmark

  15. Biologically based multistage modeling of radiation effects

    SciTech Connect (OSTI)

    William Hazelton; Suresh Moolgavkar; E. Georg Luebeck

    2005-08-30

    This past year we have made substantial progress in modeling the contribution of homeostatic regulation to low-dose radiation effects and carcinogenesis. We have worked to refine and apply our multistage carcinogenesis models to explicitly incorporate cell cycle states, simple and complex damage, checkpoint delay, slow and fast repair, differentiation, and apoptosis to study the effects of low-dose ionizing radiation in mouse intestinal crypts, as well as in other tissues. We have one paper accepted for publication in ''Advances in Space Research'', and another manuscript in preparation describing this work. I also wrote a chapter describing our combined cell-cycle and multistage carcinogenesis model that will be published in a book on stochastic carcinogenesis models edited by Wei-Yuan Tan. In addition, we organized and held a workshop on ''Biologically Based Modeling of Human Health Effects of Low dose Ionizing Radiation'', July 28-29, 2005 at Fred Hutchinson Cancer Research Center in Seattle, Washington. We had over 20 participants, including Mary Helen Barcellos-Hoff as keynote speaker, talks by most of the low-dose modelers in the DOE low-dose program, experimentalists including Les Redpath (and Mary Helen), Noelle Metting from DOE, and Tony Brooks. It appears that homeostatic regulation may be central to understanding low-dose radiation phenomena. The primary effects of ionizing radiation (IR) are cell killing, delayed cell cycling, and induction of mutations. However, homeostatic regulation causes cells that are killed or damaged by IR to eventually be replaced. Cells with an initiating mutation may have a replacement advantage, leading to clonal expansion of these initiated cells. Thus we have focused particularly on modeling effects that disturb homeostatic regulation as early steps in the carcinogenic process. There are two primary considerations that support our focus on homeostatic regulation. First, a number of epidemiologic studies using multistage carcinogenesis models that incorporate the ''initiation, promotion, and malignant conversion'' paradigm of carcinogenesis are indicating that promotion of initiated cells is the most important cellular mechanism driving the shape of the age specific hazard for many types of cancer. Second, we have realized that many of the genes that are modified in early stages of the carcinogenic process contribute to one or more of four general cellular pathways that confer a promotional advantage to cells when these pathways are disrupted.

  16. Abstract. Breast cancer is the most common cancer in women worldwide. Transformation of a normal cell to a malignant one

    E-Print Network [OSTI]

    Abstract. Breast cancer is the most common cancer in women worldwide. Transformation of a normal regulators of growth. Biomarkers associated with cancer were examined in human breast epithelial cells transformed by high-LET radiation in the presence of 17ß-estradiol. An established cancer model was used

  17. Kidney cancer is one of the most common cancers occurring in 1-2% of individuals in their

    E-Print Network [OSTI]

    O'Hern, Corey S.

    Kidney cancer is one of the most common cancers occurring in 1-2% of individuals in their lifetime. The current incidence in the United States is approximately 60,000-cases/ year. While many cancers were believed to occur sporadically, it's now understood approximately 5-8% of kidney cancers have a genetic

  18. Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells

    E-Print Network [OSTI]

    Wahl, Geoffrey M.

    Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Hospital for Sick Children, Toronto, Ontario, Canada; 4 Terry Fox Laboratory BC Cancer Research Center, Vancouver, British Columbia, Canada; 5 Moores University of California San Diego Cancer Center; 6 The Salk

  19. doi:10.1016/j.ijrobp.2006.02.044 INDUCED SECOND CANCERS AFTER PROSTATE-CANCER

    E-Print Network [OSTI]

    Brenner, David Jonathan

    doi:10.1016/j.ijrobp.2006.02.044 EDITORIAL INDUCED SECOND CANCERS AFTER PROSTATE-CANCER University Medical Center, New York, NY The absolute risks of a radiation-induced second cancer among long concern, expressed by Kendal et al. (5) in this issue, that prostate cancer patients may be unduly

  20. [CANCER RESEARCH 63, 71587166, November 1, 2003] The Gene Expression Response of Breast Cancer to Growth Regulators: Patterns

    E-Print Network [OSTI]

    Ringnér, Markus

    [CANCER RESEARCH 63, 7158­7166, November 1, 2003] The Gene Expression Response of Breast Cancer transcriptional effects elicited in MCF7, T-47D, and MDA-MB-436 breast cancer cell lines by nine regulators at the gene expression level of diverse regulators of breast cancer growth and links the behavior of breast

  1. Genetic heterogeneity of breast-ovarian cancer revisited

    SciTech Connect (OSTI)

    Narod, S.; Ford, D.; Easton, D.

    1995-10-01

    We have recently reported the results of a linkage analysis of 145 breast-ovarian cancer families. Each family has three or more cases of early-onset breast cancer (age {le}60) or of ovarian cancer, and all families have at least one case of ovarian cancer (there were nine site-specific ovarian cancer families). Overall, we estimated that 76% of the families were linked to the BRCA1 locus. 5 refs., 1 tab.

  2. Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

    E-Print Network [OSTI]

    Fendt, Sarah-Maria

    Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with increased survival in patients with cancer taking metformin; however, the mechanism by which metformin improves cancer ...

  3. Breast cancer screening disparities among ethnically diverse women in California : a latent profile analysis

    E-Print Network [OSTI]

    Gerry, Arianna Aldridge

    2011-01-01

    1998). Reducing cervical cancer among First Nations women.K. , & Edwards, B.K. (2002). Cancer survival among US whitestreatment of primary breast cancer: A systematic review.

  4. Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts

    E-Print Network [OSTI]

    Kelly, KM; Dean, J; Comulada, WS; Lee, SJ

    2010-01-01

    at high risk for breast cancer with MR imaging. Breast Can-Findings from the Breast Cancer Surveillance Consortium:women undergoing biopsy after screening mammography. Cancer

  5. Analysis of Genomic Rearrangements in Cancer from High Throughput Sequencing Data

    E-Print Network [OSTI]

    Ballinger, Tracy Jean

    2015-01-01

    2.2 Cancer evolution . . . . . . . . . . . . . . . . . . . .5 Retrotransposition in cancer genomes 5.1 Retrotransposonrearrangements in cancer . . . . . . . . 2.3.2 Graph-based

  6. Estrogen withdrawal, increased breast cancer risk and the KRAS-variant

    E-Print Network [OSTI]

    2015-01-01

    estrogen signaling and Table 5. Second breast cancer risk inKRAS- variant breast cancer patients controlling for lobularand metachronous breast cancer when controlling for lobular

  7. Progression of endometriosis to cancer: too MUCh FoxP3+ regulatory T-cell response?

    E-Print Network [OSTI]

    Prieto, G. A

    2011-01-01

    glycosylated Mucin-1 in ovarian cancer. Histopathology 57,and endometrioid ovarian cancer. Nat. Med. 11, 63-70.T. and Konishi, I. (2009). Ovarian cancer in endometriosis:

  8. Clinical characteristics of ovarian cancer classified by BRCA1, BRCA2, and RAD51C status

    E-Print Network [OSTI]

    2014-01-01

    OPEN SUBJECT AREAS: OVARIAN CANCER DISEASES Received 9Characteristics of Ovarian Cancer Classified by BRCA1,B. A. The genetics of ovarian cancer. Best Pract Res Clin

  9. Sociodemographic disparities in advanced ovarian cancer survival and adherence to treatment guidelines

    E-Print Network [OSTI]

    Bristow, RE; Chang, J; Ziogas, A; Campos, B; Chavez, LR; Anton-Culver, H

    2015-01-01

    women diagnosed with ovarian cancer in the United States. JOzols R, et al. NCCN Ovarian Cancer Practice Guidelines. Thepractice guidelines for ovarian cancer. Version 2000. Fort

  10. Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance

    E-Print Network [OSTI]

    2014-01-01

    ticellular spheroids in ovarian cancer metasta- ses: biologyNaora H, Montell DJ. Ovarian cancer metastasis: integratingpatients with primary ovarian cancer. J Surg Oncol. 2009; 6.

  11. Health anxiety and cognitive processes as risks for insomnia in women undergoing chemotherapy for breast cancer

    E-Print Network [OSTI]

    Rissling, Michelle Brosemer; Rissling, Michelle Brosemer

    2012-01-01

    symptom cluster in breast cancer patients is associated withFatigue and Sleep in Breast Cancer Patients Undergoingwomen with metastatic breast cancer. The breast journal, 8(

  12. Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci

    E-Print Network [OSTI]

    Amin Al Olama, Ali; Benlloch, Sara; Antoniou, Antonis C.; Giles, Graham G.; Severi, Gianluca; Neal, David; Hamdy, Freddie C.; Donovan, Jenny L.; Muir, Kenneth; Schleutker, Johanna; Henderson, Brian E.; Haiman, Christopher; Schumacher, Fredrick R.; Pashayan, Nora; Pharoah, Paul D. P.; Ostrander, Elaine A.; Stanford, Janet L.; Batra, Jyotsna; Clements, Judith A.; Chambers, Suzanne K.; Weischer, Maren; Nordestgaard, Børge G.; Ingles, Sue Ann; Sorensen, Karina D.; Orntoft, Torben F.; Park, Jong Y.; Cybulski, Cezary; Maier, Christiane; Doerk, Thilo; Dickinson, Joanne L.; Cannon-Albright, Lisa; Brenner, Hermann; Rebbeck, Timothy R.; Zeigler-Johnson, Charnita; Habuchi, Tomonori; Thibodeau, Stephen N.; Cooney, Kathleen; Chappuis, Pierre O.; Hutter, Pierre; Kaneva, Radka P.; Foulkes, William D.; Zeegers, Maurice P.; Lu, Yong-Jie; Zhang, Hong-Wei; Stephenson, Robert; Cox, Angela; Southey, Melissa C.; Spurdle, Amanda B.; FitzGerald, Liesel; Leongamornlert, Daniel; Saunders, Edward; Tymrakiewicz, Malgorzata; Guy, Michelle; Dadaev, Tokhir; Little, Sarah J.; Govindasami, Koveela; Sawyer, Emma; Wilkinson, Rosemary; Herkommer, Kathleen; Hopper, John L.; Lophatonanon, Aritaya; Rinckleb, Antje E.; Kote-Jarai, Zsofia; Eeles, Rosalind A.; Easton, Douglas F.

    2015-04-02

    & Prevention.pdf.txt Content-Type text/plain; charset=UTF-8 1 Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci Ali Amin Al Olama1,56, Sara Benlloch1,56, Antonis C... @medschl.cam.ac.uk Tel: 0044 1223 748638 Fax: 0044 1223 748628 Running Title: Risk Analysis of Prostate Cancer in PRACTICAL Consortium Keywords: Prostate Cancer risk, Genetic and Molecular Epidemiology, Genitourinary Cancers: Prostate, Risk...

  13. Cancer-specific variation in emergency presentation by sex, age and deprivation across 27 common and rarer cancers

    E-Print Network [OSTI]

    Abel, G. A.; Shelton, J.; Johnson, S.; Elliss-Brookes, L.; Lyratzopoulos, G.

    2015-03-03

    logistic regression model that, conditional on being a cancer case, predicts the emergency presentation status (yes/no binary variable) adjusting for age, sex, deprivation group, year of diagnosis and cancer (model 1). Subsequently, we examined whether... age groups (laryngeal, melanoma, thyroid, oral, anal, brain, oropharynx, renal cancer and soft-tissue sarcoma). For one cancer (ALL), the reverse pattern was observed. For the remaining cancers (AML, colon, stomach, oesophageal, liver, bladder, Sex6 O...

  14. Engineering persistent interleukin-2 for cancer immunotherapy

    E-Print Network [OSTI]

    Gai, Shuning

    2012-01-01

    Mobilizing the immune system to recognize and destroy tumor cells is a promising strategy for treating cancer. In contrast to standard therapeutic approaches such as surgery, radiation, and chemotherapy, immunotherapy ...

  15. Stromal Endothelial Cells Directly Influence Cancer Progression

    E-Print Network [OSTI]

    Franses, Joseph Wang

    Cancer growth and metastasis are regulated in part by stromal cells such as fibroblasts and immune cells within the tumor microenvironment. Endothelial cells (ECs) are also ubiquitous within tumors because tumors are ...

  16. Cancer systems biology: a network modeling perspective

    E-Print Network [OSTI]

    Lauffenburger, Douglas A.

    Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell type and tissue origin but also as a disease involving dysregulation of multiple pathways governing fundamental cell processes such ...

  17. Regulation of apoptosis in human cancer cells

    E-Print Network [OSTI]

    Lloyd, S. Julie-Ann (Simone Julie-Ann)

    2005-01-01

    Nitric oxide is postulated to protect cancer cells from the death-inducing effects of tumour necrosis factor alpha by S-nitrosating the active site cysteines, inhibiting cleavage of caspase-9. We aimed to test this hypothesis ...

  18. Micro and nanotechnology for cancer treatment

    E-Print Network [OSTI]

    Ullal, Adeeti (Adeeti Vedantham)

    2013-01-01

    Cancer is responsible for over 7.6 million deaths worldwide; the majority of patients fail to respond to drugs or become resistant over time. In order to gain a better understanding of drug efficacy in patients, we developed ...

  19. Development of New Treatments for Prostate Cancer

    SciTech Connect (OSTI)

    DiPaola, R. S.; Abate-Shen, C.; Hait, W. N.

    2005-02-01

    The Dean and Betty Gallo Prostate Cancer Center (GPCC) was established with the goal of eradicating prostate cancer and improving the lives of men at risk for the disease through research, treatment, education and prevention. GPCC was founded in the memory of Dean Gallo, a beloved New Jersey Congressman who died tragically of prostate cancer diagnosed at an advanced stage. GPCC unites a team of outstanding researchers and clinicians who are committed to high-quality basic research, translation of innovative research to the clinic, exceptional patient care, and improving public education and awareness of prostate cancer. GPCC is a center of excellence of The Cancer Institute of New Jersey, which is the only NCI-designated comprehensive cancer center in the state. GPCC efforts are now integrated well as part of our Prostate Program at CINJ, in which Dr. Robert DiPaola and Dr. Cory Abate-Shen are co-leaders. The Prostate Program unites 19 investigators from 10 academic departments who have broad and complementary expertise in prostate cancer research. The overall goal and unifying theme is to elucidate basic mechanisms of prostate growth and oncogenesis, with the ultimate goal of promoting new and effective strategies for the eradication of prostate cancer. Members' wide range of research interests collectively optimize the chances of providing new insights into normal prostate biology and unraveling the molecular pathophysiology of prostate cancer. Cell culture and powerful animal models developed by program members recapitulate the various stages of prostate cancer progression, including prostatic intraepithelial neoplasia, adenocarcinoma, androgen-independence, invasion and metastases. These models promise to further strengthen an already robust program of investigator-initiated therapeutic clinical trials, including studies adopted by national cooperative groups. Efforts to translate laboratory results into clinical studies of early detection and chemoprevention are underway. The specific goals of this program are: (1) To investigate the molecular mechanisms underlying normal prostate growth and differentiation and elucidate the molecular mechanisms underlying prostate oncogenesis. (2) To build on fundamental knowledge to develop effective therapeutic approaches for the treatment of prostate cancer. (3) To improve the control of prostate cancer through early detection, chemoprevention, and outreach and education. This new disease-based program is structured to improve interdisciplinary interactions and translational results. Already, through the dynamic leadership of Drs. Cory Abate-Shen and Robert DiPaola, new investigators were attracted to the field, new collaborations engendered, and numerous investigator-initiated trials implemented. Progress in GPCC and the program overall has been outstanding. The Center has success in uniting investigators with broad and complementary expertise in prostate cancer research. The overall goal and unifying theme is to elucidate basic mechanisms of prostate growth and oncogenesis, with the ultimate goal of promoting new and effective strategies for the eradication of prostate cancer in patients and populations at risk. Members wide range of research interests collectively optimize the chances of providing new insights into normal prostate biology and unraveling the molecular pathophysiology of prostate cancer. Studies in cell culture and powerful animal models developed recapitulate the various stages of prostate cancer progression, including prostatic intraepithelial neoplasia, adenocarcinoma, androgen-independence, invasion and metastases. These models promise to further strengthen an already robust program of investigator-initiated therapeutic clinical trials, including studies adopted by national cooperative groups. Efforts to translate laboratory results into clinical studies of early detection and chemoprevention are underway.

  20. Focus on the Physics of Cancer

    E-Print Network [OSTI]

    Risler, Thomas

    2015-01-01

    Despite the spectacular achievements of molecular biology in the second half of the twentieth century and the crucial advances it permitted in cancer research, the fight against cancer has brought some disillusions. It is nowadays more and more apparent that getting a global picture of the very diverse and interlinked aspects of cancer development necessitates, in synergy with these achievements, other perspectives and investigating tools. In this undertaking, multidisciplinary approaches that include quantitative sciences in general and physics in particular play a crucial role. This `focus on' collection contains 19 articles representative of the diversity and state-of-the-art of the contributions that physics can bring to the field of cancer research.

  1. Cancer Cell Metabolism: One Hallmark, Many Faces

    E-Print Network [OSTI]

    Sabatini, David M.

    Cancer cells must rewire cellular metabolism to satisfy the demands of growth and proliferation. Although many of the metabolic alterations are largely similar to those in normal proliferating cells, they are aberrantly ...

  2. Regulatory roles of endothelial cells in cancer

    E-Print Network [OSTI]

    Franses, Joseph W. (Joseph Wang)

    2011-01-01

    This thesis describes the biochemical regulatory impact of endothelial cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view ...

  3. Investigation into taxane resistant breast cancer 

    E-Print Network [OSTI]

    Kenicer, Juliet Elisabeth Margaret

    2011-11-25

    One group of chemotherapeutics that are used successfully to treat breast cancer, alone or in combination with other agents, are the taxanes; paclitaxel and docetaxel. They act by interfering with the spindle microtubule ...

  4. Breast Density and Cancer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Breast Cancer Awareness Series: Understanding Breast Density Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in...

  5. Photoswitchable nanoparticles for in vivo cancer chemotherapy

    E-Print Network [OSTI]

    Tong, Rong

    There are many obstacles to effective cancer chemotherapy, including drug penetration and accumulation in tumors and drug systemic toxicity. The penetration of therapies into tumors is limited by the dense tumor matrix and ...

  6. Somatic retrotransposition in the cancer genome

    E-Print Network [OSTI]

    Helman, Elena

    2014-01-01

    Cancer is a complex disease of the genome exhibiting myriad somatic mutations, from single nucleotide changes to various chromosomal rearrangements. The technological advances of next-generation sequencing enable high-throughput ...

  7. Mueller matrix imaging for skin cancer detection 

    E-Print Network [OSTI]

    Baldwin, Angela Michelle

    2004-09-30

    is suspect, a biopsy is performed to verify the diagnosis. For squamous cell and basal cell carcinomas, the most common treatment options are excision, curettage and electrodesiccation, cryosurgery, radiation, and Moh?s micrographic surgery. Excision... is where all visible cancer is cut away together with a 3 to 10 mm margin of healthy tissue and then the skin is stitched closed with sutures. Curettage and electrodesiccation are where all visible cancer is scraped away and then an electric probe...

  8. Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer

    SciTech Connect (OSTI)

    Spellman, Paul T.; Heiser, Laura; Gray, Joe W.

    2009-06-18

    Breast cancer is predominantly a disease of the genome with cancers arising and progressing through accumulation of aberrations that alter the genome - by changing DNA sequence, copy number, and structure in ways that that contribute to diverse aspects of cancer pathophysiology. Classic examples of genomic events that contribute to breast cancer pathophysiology include inherited mutations in BRCA1, BRCA2, TP53, and CHK2 that contribute to the initiation of breast cancer, amplification of ERBB2 (formerly HER2) and mutations of elements of the PI3-kinase pathway that activate aspects of epidermal growth factor receptor (EGFR) signaling and deletion of CDKN2A/B that contributes to cell cycle deregulation and genome instability. It is now apparent that accumulation of these aberrations is a time-dependent process that accelerates with age. Although American women living to an age of 85 have a 1 in 8 chance of developing breast cancer, the incidence of cancer in women younger than 30 years is uncommon. This is consistent with a multistep cancer progression model whereby mutation and selection drive the tumor's development, analogous to traditional Darwinian evolution. In the case of cancer, the driving events are changes in sequence, copy number, and structure of DNA and alterations in chromatin structure or other epigenetic marks. Our understanding of the genetic, genomic, and epigenomic events that influence the development and progression of breast cancer is increasing at a remarkable rate through application of powerful analysis tools that enable genome-wide analysis of DNA sequence and structure, copy number, allelic loss, and epigenomic modification. Application of these techniques to elucidation of the nature and timing of these events is enriching our understanding of mechanisms that increase breast cancer susceptibility, enable tumor initiation and progression to metastatic disease, and determine therapeutic response or resistance. These studies also reveal the molecular differences between cancer and normal that may be exploited to therapeutic benefit or that provide targets for molecular assays that may enable early cancer detection, and predict individual disease progression or response to treatment. This chapter reviews current and future directions in genome analysis and summarizes studies that provide insights into breast cancer pathophysiology or that suggest strategies to improve breast cancer management.

  9. Radiation Dose and Subsequent Risk for Stomach Cancer in Long-term Survivors of Cervical Cancer

    SciTech Connect (OSTI)

    Kleinerman, Ruth A.; Smith, Susan A.; Holowaty, Eric; Hall, Per; Pukkala, Eero; Vaalavirta, Leila; Stovall, Marilyn; Weathers, Rita; Gilbert, Ethel; Aleman, Berthe M.P.; Kaijser, Magnus; Andersson, Michael; Storm, Hans; Joensuu, Heikki; Lynch, Charles F.; and others

    2013-08-01

    Purpose: To assess the dose–response relationship for stomach cancer after radiation therapy for cervical cancer. Methods and Materials: We conducted a nested, matched case–control study of 201 cases and 378 controls among 53,547 5-year survivors of cervical cancer diagnosed from 1943 to 1995, from 5 international, population-based cancer registries. We estimated individual radiation doses to the site of the stomach cancer for all cases and to corresponding sites for the matched controls (overall mean stomach tumor dose, 2.56 Gy, range 0.03-46.1 and after parallel opposed pelvic fields, 1.63 Gy, range 0.12-6.3). Results: More than 90% of women received radiation therapy, mostly with external beam therapy in combination with brachytherapy. Stomach cancer risk was nonsignificantly increased (odds ratio 1.27-2.28) for women receiving between 0.5 and 4.9 Gy to the stomach cancer site and significantly increased at doses ?5 Gy (odds ratio 4.20, 95% confidence interval 1.41-13.4, P{sub trend}=.047) compared with nonirradiated women. A highly significant radiation dose–response relationship was evident when analyses were restricted to the 131 cases (251 controls) whose stomach cancer was located in the middle and lower portions of the stomach (P{sub trend}=.003), whereas there was no indication of increasing risk with increasing dose for 30 cases (57 controls) whose cancer was located in the upper stomach (P{sub trend}=.23). Conclusions: Our findings show for the first time a significant linear dose–response relationship for risk of stomach cancer in long-term survivors of cervical cancer.

  10. Cantilever MEMS Detection ofCantilever MEMS Detection of CancerCancer

    E-Print Network [OSTI]

    Petta, Jason

    Cantilever MEMS Detection ofCantilever MEMS Detection of CancerCancer O. Bravo, C. Milburn, W, NJ 08544 #12;OutlineOutline Introduction of bioMEMS AFM platform schematics Nanoindentations Vimentin antigen Graphs and data Clinical implications Future work #12;Introduction to BioMEMS Structure

  11. A filter-based feature selection approach for identifying potential biomarkers for lung cancer

    E-Print Network [OSTI]

    Lee, In-Hee; Lushington, Gerald H.; Visvanathan, Mahesh

    2011-03-21

    Background: Lung cancer is the leading cause of death from cancer in the world and its treatment is dependant on the type and stage of cancer detected in the patient. Molecular biomarkers that can characterize the cancer ...

  12. Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

    E-Print Network [OSTI]

    2012-01-01

    of lung cancer,” Clinical Cancer Research, vol. 4, no. 7,pathogenesis of lung cancer,” Annual Review of Physiology,immunoreac- tivity in lung cancer: yet another player in the

  13. An intraperitoneal implantable drug delivery device for the treatment of ovarian cancer

    E-Print Network [OSTI]

    Ye, Hongye

    2014-01-01

    Ovarian cancer is the fifth leading cause of cancer-related deaths in women and the deadliest gynecologic cancer. The current standard treatment for advanced ovarian cancer includes a minimally invasive cytoreduction ...

  14. Links Between Inflammation, Amygdala Reactivity, and Social Support in Breast Cancer Survivors.

    E-Print Network [OSTI]

    Muscatell, KA; Eisenberger, NI; Dutcher, JM; Cole, SW; Bower, JE

    2015-01-01

    women with advanced ovarian cancer. Cancer, 104, 305-313.outcomes of patients with ovarian cancer. J Clin Oncol, 30,killer cell activity in ovarian cancer. J Clin Oncol, 23,

  15. Vascular endothelial growth factor (VEGF) expression in locally advanced prostate cancer: secondary analysis of radiation therapy oncology group (RTOG) 8610

    E-Print Network [OSTI]

    2013-01-01

    of Radiation Oncology, Prince Edward Island Cancer Treatmentof Radiation Oncology, Prince Edward Island Cancer Treatment

  16. Online prediction of ovarian cancer

    E-Print Network [OSTI]

    Zhdanov, Fedor; Burford, Brian; Devetyarov, Dmitry; Nouretdinov, Ilia; Gammerman, Alex

    2009-01-01

    In this paper we apply computer learning methods to diagnosing ovarian cancer using the level of the standard biomarker CA125 in conjunction with information provided by mass-spectrometry. We are working with a new data set collected over a period of 7 years. Using the level of CA125 and mass-spectrometry peaks, our algorithm gives probability predictions for the disease. To estimate classification accuracy we convert probability predictions into strict predictions. Our algorithm makes fewer errors than almost any linear combination of the CA125 level and one peak's intensity (taken on the log scale). To check the power of our algorithm we use it to test the hypothesis that CA125 and the peaks do not contain useful information for the prediction of the disease at a particular time before the diagnosis. Our algorithm produces $p$-values that are better than those produced by the algorithm that has been previously applied to this data set. Our conclusion is that the proposed algorithm is more reliable for predi...

  17. The role of uPAR signaling in lung cancer Background and significance

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    The role of uPAR signaling in lung cancer Background and significance Lung cancer is the leading of lung cancer ­ non-small-cell-lung cancer (about 85% of all lung cancer cases) and small- cell-lung cancer (about 15%) (Herbst et al., 2008). Small cell lung carcinoma (SCLC) is rapidly growing and often

  18. Cold atmospheric plasma in cancer therapy

    SciTech Connect (OSTI)

    Keidar, Michael; Shashurin, Alex; Volotskova, Olga; Ann Stepp, Mary; Srinivasan, Priya; Sandler, Anthony; Trink, Barry

    2013-05-15

    Recent progress in atmospheric plasmas has led to the creation of cold plasmas with ion temperature close to room temperature. This paper outlines recent progress in understanding of cold plasma physics as well as application of cold atmospheric plasma (CAP) in cancer therapy. Varieties of novel plasma diagnostic techniques were developed recently in a quest to understand physics of CAP. It was established that the streamer head charge is about 10{sup 8} electrons, the electrical field in the head vicinity is about 10{sup 7} V/m, and the electron density of the streamer column is about 10{sup 19} m{sup ?3}. Both in-vitro and in-vivo studies of CAP action on cancer were performed. It was shown that the cold plasma application selectively eradicates cancer cells in-vitro without damaging normal cells and significantly reduces tumor size in-vivo. Studies indicate that the mechanism of action of cold plasma on cancer cells is related to generation of reactive oxygen species with possible induction of the apoptosis pathway. It is also shown that the cancer cells are more susceptible to the effects of CAP because a greater percentage of cells are in the S phase of the cell cycle.

  19. Oestrogen metabolism and action in epithelial ovarian cancer 

    E-Print Network [OSTI]

    Ren, Xia

    2011-11-25

    Ovarian cancer is the most fatal of all gynecological malignancies. Epithelial ovarian cancer (EOC) accounts for about 90% of malignant ovarian tumours and is thought to originate mostly from ovarian surface epithelium ...

  20. www.yalecancercenter.org The Biology of Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org The Biology of Lung Cancer Guest Expert: Katerina Politi, PhD www lung cancers and cutaneous lymphomas. If you would like to join the conversation, you can contact

  1. SCHOOL OF GRADUATE STUDIES CANCER RESEARCHwww.queensu.ca/cancergradprogram

    E-Print Network [OSTI]

    Fletcher, Robin

    and genetics, through epidemiology, to outcomes research, cell signaling and health policy development designated Cancer Research courses. · Participate in the Cancer Research Seminar Series. SUPERVISORS that increase individual susceptibility to carcinogens. Trainees will conduct research developing or employing

  2. Comprehensive genomic characterization of squamous cell lung cancers

    E-Print Network [OSTI]

    Lander, Eric S.

    Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no ...

  3. Molecular Mechanisms of Cannabinoids as Anti-cancer Agents 

    E-Print Network [OSTI]

    Sreevalsan, Sandeep

    2013-05-31

    Cancer is a growing health concern world-wide and is the second most common cause of death after heart diseases. Current treatment strategies such as surgery, chemotherapy and radiation provide some relief to cancer patients ...

  4. Designer Proteins Target Epstein-Barr-Virus-Associated Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    protein inhibitor of EBV-associated cancer, and can now be used to design proteins to fight other infectious agents and cancers. Some viruses plan for this, and produce proteins...

  5. Microfabricated Optical Sensor Probe for the Detection of Esophageal Cancer 

    E-Print Network [OSTI]

    Chinna Balareddy, Karthik Reddy

    2012-10-19

    Cancer is a class of diseases in which a group of cells grow uncontrollably, destroy surrounding tissue and eventually spread to other parts of the body, often leading to death. According to the American Cancer Society ...

  6. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Enzyme Structure Provides Insights into Cancer and Aging Enzyme Structure Provides Insights into Cancer and Aging Print Wednesday, 25 February 2009 00:00 XPD helicase is an enzyme...

  7. Boron-Nitride Nanotubes Show Potential in Cancer Treatment |...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Boron-Nitride Nanotubes Show Potential in Cancer Treatment NEWPORT NEWS, VA, April 26 - A new study has shown that adding boron-nitride nanotubes to the surface of cancer cells can...

  8. Function of the anterior gradient protein family in cancer 

    E-Print Network [OSTI]

    Fourtouna, Argyro

    2009-01-01

    Proteomic technologies verified Anterior Gradient 2, AGR-2, as a protein over-expressed in human cancers, including breast, prostate and oesophagus cancers, with the ability to inhibit the tumour suppressor protein p53. AGR-2 gene is a hormone...

  9. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  10. Breaking a Pocket of Resistance in the Fight Against Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Breaking a Pocket of Resistance in the Fight Against Cancer Breaking a Pocket of Resistance in the Fight Against Cancer Print Thursday, 12 December 2013 11:55 ras protein The new...

  11. Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer

    E-Print Network [OSTI]

    Ooi, Chia Huey

    Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric cancer (GC) with significant relationships ...

  12. Spiritual Coping and Adjustment in Siblings of Children with Cancer 

    E-Print Network [OSTI]

    Kaal, Julia

    2011-11-23

    Approximately 12 000 US children are diagnosed with some form of cancer every year (Ries et al., 2006).

  13. Vitamin E and the risk of prostate cancer: Updated results of the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

    E-Print Network [OSTI]

    2012-01-01

    10.1001/jama.2011.1437. Vitamin E and the Risk of Prostateof The Selenium and Vitamin E Cancer Prevention Trial (Effect of Selenium and Vitamin E on Risk of Prostate Cancer

  14. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

    E-Print Network [OSTI]

    Ren, Yin

    A comprehensive understanding of the molecular vulnerabilities of every type of cancer will provide a powerful roadmap to guide therapeutic approaches. Efforts such as The Cancer Genome Atlas Project will identify genes ...

  15. Algorithms for Detecting Significantly Mutated Pathways in Cancer

    E-Print Network [OSTI]

    Raphael, Ben J.

    Algorithms for Detecting Significantly Mutated Pathways in Cancer Fabio Vandin1, , Eli Upfal2 genome sequencing studies have shown that the so- matic mutations that drive cancer development functional mutations from sporadic, passenger mutations. Since cancer mutations are hypothesized to target

  16. Modeling cancer metabolism on a genome scale Keren Yizhak1,*

    E-Print Network [OSTI]

    Ruppin, Eytan

    Review Modeling cancer metabolism on a genome scale Keren Yizhak1,* , Barbara Chaneton2 , Eyal Gottlieb2 & Eytan Ruppin1,3,4,** Abstract Cancer cells have fundamentally altered cellular metabolism, several new key metabolic alterations in cancer have been established over the last decade, leading

  17. www.yalecancercenter.org Robotic Surgery for Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Robotic Surgery for Lung Cancer Guest Expert: Anthony Kim, MD Assistant and an expert in the use of radiation to treat lung cancers and cutaneous lymphomas. If you would like to join for a conversation about robotic surgery for lung cancer. Here is Francine Foss. Foss Let's start off by talking

  18. www.yalecancercenter.org Non-Small Cell Lung Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    www.yalecancercenter.org Non-Small Cell Lung Cancer Therapies Guest Expert: Roy Decker, MD, Ph Scott, let's start off by discussing why lung cancer is still such a significant public health problem it has decreased in the last 10- 15 years. The incidence of lung cancer might be decreasing a little

  19. EPA 402-R-93-076 ESTIMATING RADIOGENIC CANCER RISKS

    E-Print Network [OSTI]

    comparing health risk estimates due to low level exposures of low-LET radiation based on models recently This document presents a revised methodology for EPA's estimation of cancer risks due to low-LET radiation. With the exception of breast cancer, low-LET radiogenic cancer risks are assumed to be reduced by a dose and dose

  20. [CANCER RESEARCH 62, 56185621, October 1, 2002] Meeting Report

    E-Print Network [OSTI]

    Kimchi, Adi

    [CANCER RESEARCH 62, 5618­5621, October 1, 2002] Meeting Report Progress in Differentiation of Cancer Research, Chester Beatty Laboratories, London, United Kingdom [A. Z.]; Department of Molecular and pro- grammed cell death as cancer cell-selective therapies. As in the past, the organizers

  1. Cancer Cell Dissecting the Unique Role of the Retinoblastoma

    E-Print Network [OSTI]

    Cancer Cell Article Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during-cycle control. However, cancer-associated mutations are almost exclusively found in RB, implying that RB has for cancer development; hence, the roles and regulation of RB have been intensively studied (reviewed

  2. Cancer Phylogenetics from Single-Cell Assays Gregory Pennington

    E-Print Network [OSTI]

    Cancer Phylogenetics from Single-Cell Assays Gregory Pennington Stanley Shackney Russell Schwartz the Carnegie Mellon University Berkman Faculty Development Fund. #12;Keywords: computational biology, cancer, FISH, phylogeny #12;Abstract In the field of cancer biology, there is currently great interest

  3. Skin cancer detection by oblique-incidence diffuse reflectance spectroscopy 

    E-Print Network [OSTI]

    Smith, Elizabeth Brooks

    2009-05-15

    Skin cancer is the most common form of cancer and it is on the rise. If skin cancer is diagnosed early enough, the survival rate is close to 90%. Oblique-incidence diffuse reflectance (OIR) spectroscopy offers a technology that may be used...

  4. Cancer Pain Management: A Jordanian Perspective Ibraheem Bashayreh(a)

    E-Print Network [OSTI]

    Cancer Pain Management: A Jordanian Perspective Ibraheem Bashayreh(a) , Davina Porock(b) , Nick of the study: was to evaluate the attitudinal barriers to cancer-pain management among cnacer patients five factors . These factors contribute to ineffective cancer pain management among them and include

  5. [CANCER RESEARCH 61, 59745978, August 15, 2001] Advances in Brief

    E-Print Network [OSTI]

    Jin, Jiashun

    [CANCER RESEARCH 61, 5974­5978, August 15, 2001] Advances in Brief Analysis of Gene Expression Identifies Candidate Markers and Pharmacological Targets in Prostate Cancer John B. Welsh, Lisa M. Sapinoso., H. F. F.] Abstract Detection, treatment, and prediction of outcome for men with prostate cancer

  6. No Evidence of Dioxin Cancer Threshold David Mackie1

    E-Print Network [OSTI]

    Thomas, Valerie

    1 No Evidence of Dioxin Cancer Threshold David Mackie1 , Junfeng Liu1 , Yeong-Shang Loh2 , Valerie Environmental Institute, Guyot Hall, Princeton University, Princeton NJ 08544 #12;2 No Evidence of Dioxin Cancer Threshold Key Words: Dioxin, TCDD, Cancer, Threshold Acknowledgements: This work was carried out as part

  7. [CANCER RESEARCH 64, 46934698, July 15, 2004] Advances in Brief

    E-Print Network [OSTI]

    Meucci, Olimpia

    [CANCER RESEARCH 64, 4693­4698, July 15, 2004] Advances in Brief CX3CR1-Fractalkine Expression Regulates Cellular Mechanisms Involved in Adhesion, Migration, and Survival of Human Prostate Cancer Cells of specific organs by metastatic cancer cells. For instance, the CXCR4- SDF-1 pair regulates adhesion

  8. DISCOVERY OF MUTATED SUBNETWORKS ASSOCIATED WITH CLINICAL DATA IN CANCER

    E-Print Network [OSTI]

    Raphael, Ben J.

    DISCOVERY OF MUTATED SUBNETWORKS ASSOCIATED WITH CLINICAL DATA IN CANCER FABIO VANDIN, PATRICK CLAY,pclay,eli,braphael}@cs.brown.edu A major goal of cancer sequencing projects is to identify genetic alterations that determine clinical phenotypes, such as survival time or drug response. Somatic mutations in cancer are typically very diverse

  9. An analysis and hypothesis generation platform for heterogeneous cancer

    E-Print Network [OSTI]

    Reed, Chris

    An analysis and hypothesis generation platform for heterogeneous cancer databases. Philip Roy QUINLAN a,1, Alastair THOMPSON a and Chris REED b a Dundee Cancer Centre, University of Dundee, Ninewells Hospital, Dundee b School of Computing, University of Dundee, Dundee Abstract. The field of cancer research

  10. Glucose conjugation for the specific targeting and treatment of cancer

    E-Print Network [OSTI]

    Hergenrother, Paul J.

    Glucose conjugation for the specific targeting and treatment of cancer Emilia C. Calvaresia and Paul J. Hergenrother*ab Cancers of diverse origins exhibit marked glucose avidity and high rates has led to an interest in targeting it for cancer therapy. One promising strategy for such targeting

  11. Estimating Volumes of Simulated Lung Cancer Nodules David E. Gilsinn

    E-Print Network [OSTI]

    Gilsinn, David E.

    Estimating Volumes of Simulated Lung Cancer Nodules David E. Gilsinn Bruce R. Borchardt Amelia Tebbe§ July 15, 2009 Abstract Lung cancer is a disease of uncontrolled cell growth in tissues of the lung. Computed to- mography (CT) shows promise in detecting lung cancers at earlier, more operable

  12. Targeted CT Screening for Lung Cancer using Absolute Risk Prediction

    E-Print Network [OSTI]

    Brent, Roger

    Targeted CT Screening for Lung Cancer using Absolute Risk Prediction Stephanie A. Kovalchik skovalch@rand.org FHCRC 2014 Risk Prediction Symposium June 11, 2014 1 #12;Outline · Lung Cancer Epidemiology and Screening · Screening Benefit and Absolute Risk · Absolute Risk Model for Lung Cancer

  13. Research Article Epithelial Phenotype Confers Resistance of Ovarian Cancer

    E-Print Network [OSTI]

    Hemminki, Akseli

    Research Article Epithelial Phenotype Confers Resistance of Ovarian Cancer Cells to Oncolytic, Helsinki, Finland Abstract We studied the susceptibility of primary ovarian cancer cells to oncolytic oncolysis, we discovered that the epithelial phenotype of ovarian cancer represents a barrier to infection

  14. Transcriptional Targeting for Ovarian Cancer Gene Therapy E. Casado,*,

    E-Print Network [OSTI]

    Hemminki, Akseli

    REVIEW Transcriptional Targeting for Ovarian Cancer Gene Therapy E. Casado,*, D. M. Nettelbeck Paz, Madrid, Spain Received November 10, 2000 Ovarian carcinoma is a leading cause of cancer death patients diagnosed with ovarian cancer are still low. Therefore, novel molecular therapeutic strat- egies

  15. Physiologic, Metabolic, and Structural Alterations in Breast Cancer

    E-Print Network [OSTI]

    Ramanujam, Nimmi

    Physiologic, Metabolic, and Structural Alterations in Breast Cancer: Assessment via Optical;MOTIVATION METHODOLOGY / TOOLS VALIDATION EX VIVO ANALYSIS IN VIVO ANALYSIS Breast Cancer ­ Facts and Figures · Approx. 213,000 women in the US develop invasive breast cancer each year; 62,000 are diagnosed

  16. PRECLINICAL STUDY Prediction of lymph node involvement in breast cancer

    E-Print Network [OSTI]

    PRECLINICAL STUDY Prediction of lymph node involvement in breast cancer from primary tumor tissue- ther lymph node involvement in breast cancer is influenced by gene or miRNA expression of the primary tissue from a group of 96 breast cancer patients balanced for lymph node involvement using Affymetrix

  17. Predicting breast cancer using an expression values weighted clinical classifier

    E-Print Network [OSTI]

    Predicting breast cancer using an expression values weighted clinical classifier Minta Thomas 1. Results: We compared and evaluated the proposed methods on five breast cancer case studies. Compared to LS Curve (AUC), on all breast cancer case studies. Conclusions: Thus a clinical classifier weighted

  18. Implanted adipose progenitor cells as physicochemical regulators of breast cancer

    E-Print Network [OSTI]

    Cohen, Itai

    Implanted adipose progenitor cells as physicochemical regulators of breast cancer Emily M that soluble factors from breast cancer cells inhibit adipogenic differentiation while increasing proliferation surgery for breast cancer, which compose the majority of the 93,000 breast reconstructions per- formed

  19. METHODOLOGY ARTICLE Open Access A simple and reproducible breast cancer

    E-Print Network [OSTI]

    Geman, Donald

    METHODOLOGY ARTICLE Open Access A simple and reproducible breast cancer prognostic test Luigi test for breast cancer based on a 70-gene expression signature. We provide all the software, Personalized medicine, Breast cancer, MammaPrint Background Currently, a number of molecular-based prognostic

  20. COMPUTERIZED BREAST CANCER DIAGNOSIS AND PROGNOSIS FROM FINE NEEDLE ASPIRATES

    E-Print Network [OSTI]

    Street, Nick

    1 COMPUTERIZED BREAST CANCER DIAGNOSIS AND PROGNOSIS FROM FINE NEEDLE ASPIRATES William H. Wolberg methods based on linear programming that were applicable to breast cancer diagnosis and prognostic), and 2) improve breast cancer prognostic estimations. The diagnostic accuracy of FNA to diagnose breast

  1. The Reproductive Factors Linked to Breast Cancer Risk

    E-Print Network [OSTI]

    Chen, Tsuhan

    The Reproductive Factors Linked to Breast Cancer Risk The breast is a reproductive organ, so it makes sense that breast cancer risk would be related to reproductive variables. A woman's own estrogen contributes to the normal development and functioning of the breast, as well as to breast cancer risk. Being

  2. A Systems Approach to Breast Cancer Carcinogenesis to Therapy

    E-Print Network [OSTI]

    A Systems Approach to Breast Cancer ­ Carcinogenesis to Therapy Speaker: Dr. Joe Gray Director, Center for Spatial Systems Biomedicine Oregon Health & Science University Date: Monday, April 18, 2011 that influence cancer behavior, (b) systems biology approaches to elucidate mechanisms by which cancer

  3. Lung Cancer . Author manuscript p16INK4A inactivation mechanisms in non-small-cell lung cancer patients

    E-Print Network [OSTI]

    Boyer, Edmond

    Lung Cancer . Author manuscript Page /1 10 p16INK4A inactivation mechanisms in non-small-cell lung occupational risk factor and that asbestos acts synergistically with tobacco smoking to induce lung cancer. Although some somatic gene alterations in lung cancer have been linked to tobacco smoke, few data

  4. Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: A role in ovarian pathogenesis

    E-Print Network [OSTI]

    Nanjundan, Meera

    2009-01-01

    beta} Signaling in Ovarian Cancer. Cancer Res, 66, 8404-coincides with ovarian cancer resistance to transformingproliferation of human ovarian cancer cells obtained from

  5. Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities

    E-Print Network [OSTI]

    Langland, Gregory T.

    2011-01-01

    platinumresistant ovarian cancer. Expert Opin Pharmacothertherapy in advanced ovarian cancer. Gynecol Oncol 90: S8-The molecular basis of ovarian cancer. Cancer 76 (Suppl 10):

  6. Challenges associated with the targeted delivery of gelonin to claudin-expressing cancer cells with the use of activatable cell penetrating peptides to enhance potency

    E-Print Network [OSTI]

    Yuan, Xiaoqin; Lin, Xinjian; Manorek, Gerald; Howell, Stephen B

    2011-01-01

    overexpressed in ovarian cancer but not in ovariandifferentially expressed in ovarian cancer. Cancer Res 2000,markers for epithelial ovarian cancer with gene expression

  7. Mutational heterogeneity in cancer and the search for new cancer genes

    E-Print Network [OSTI]

    Helman, Elena

    Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched ...

  8. Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies

    SciTech Connect (OSTI)

    Ana J. Molinari; Romina F. Aromando; Maria E. Itoiz; Marcela A. Garabalino; Andrea Monti Hughes; Elisa M. Heber; Emiliano C. C. Pozzi; David W. Nigg; Veronica A. Trivillin; Amanda E. Schwint

    2012-07-01

    Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.

  9. Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)

    E-Print Network [OSTI]

    2012-01-01

    Comparison of 6q25 Breast Cancer Hits from Asian andStudies in the Breast Cancer Association Consortium (BCAC)7 | Issue 8 | e42380 6q25 Breast Cancer GWAS Hits B. ]; the

  10. Small RNA combination therapy for lung cancer

    E-Print Network [OSTI]

    Tammela, Tuomas

    MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we show that a new lung-targeting nanoparticle is capable of delivering ...

  11. Advances in cancer research: Volume 47

    SciTech Connect (OSTI)

    Klein, G.; Weinhouse, S.

    1986-01-01

    This book contains eight chapters. Some of the titles are: Genetic Epidemiology of Familial Aggregation of Cancer; Terminal Transferase in Normal and Leukemic Cells; Malignant Metamorphosis: Developmental Genes as Culprits for Oncogenesis in Xiphophorus; and Transcription Activation by Viral and Cellular Oncogenes.

  12. Isotope Cancer Treatment Research at LANL

    ScienceCinema (OSTI)

    Weidner, John; Nortier, Meiring

    2014-06-02

    Los Alamos National Laboratory has produced medical isotopes for diagnostic and imaging purposes for more than 30 years. Now LANL researchers have branched out into isotope cancer treatment studies. New results show that an accelerator-based approach can produce clinical trial quantities of actinium-225, an isotope that has promise as a way to kill tumors without damaging surrounding healthy cells.

  13. Original Articles The Nested Structure of Cancer

    E-Print Network [OSTI]

    Bhavnani, Suresh K.

    for the design of systems that assist in symptom assessment and man- agement.The main limitation of the studyOriginal Articles The Nested Structure of Cancer Symptoms Implications for Analyzing Co; 2Michigan Institute for Clinical and Health Research, Ann Arbor, MI, USA; 3Electrical Engineering

  14. Breast Cancer Detection Using Multilevel Thresholding

    E-Print Network [OSTI]

    Rejani, Y Ireaneus Anna

    2009-01-01

    This paper presents an algorithm which aims to assist the radiologist in identifying breast cancer at its earlier stages. It combines several image processing techniques like image negative, thresholding and segmentation techniques for detection of tumor in mammograms. The algorithm is verified by using mammograms from Mammographic Image Analysis Society. The results obtained by applying these techniques are described.

  15. Downregulation of tumor suppressor QKI in gastric cancer and its implication in cancer prognosis

    SciTech Connect (OSTI)

    Bian, Yongqian [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China); Wang, Li; Lu, Huanyu; Yang, Guodong [The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032 (China); Zhang, Zhang [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China); Fu, Haiyan; Lu, Xiaozhao; Wei, Mengying [The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032 (China); Sun, Jianyong; Zhao, Qingchuan [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China); Dong, Guanglong, E-mail: gldong301@gmail.com [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China) [The State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an 710032 (China); Department of General Surgery, The General Hospital of the PLA, Beijing 100853 (China); Lu, Zifan, E-mail: luzfliuq@fmmu.edu.cn [The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032 (China)] [The State Key Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an 710032 (China)

    2012-05-25

    Highlights: Black-Right-Pointing-Pointer QKI expression is decreased in gastric cancer samples. Black-Right-Pointing-Pointer Promoter hyper methylation contributes to the downregulation of QKI. Black-Right-Pointing-Pointer QKI inhibits the growth of gastric cancer cells. Black-Right-Pointing-Pointer Decreased QKI expression predicts poor survival. -- Abstract: Gastric cancer (GC) is the fourth most common cancer and second leading cause of cancer-related death worldwide. RNA-binding protein Quaking (QKI) is a newly identified tumor suppressor in multiple cancers, while its role in GC is largely unknown. Our study here aimed to clarify the relationship between QKI expression with the clinicopathologic characteristics and the prognosis of GC. In the 222 GC patients' specimens, QKI expression was found to be significantly decreased in most of the GC tissues, which was largely due to promoter hypermethylation. QKI overexpression reduced the proliferation ability of GC cell line in vitro study. In addition, the reduced QKI expression correlated well with poor differentiation status, depth of invasion, gastric lymph node metastasis, distant metastasis, advanced TNM stage, and poor survival. Multivariate analysis showed QKI expression was an independent prognostic factor for patient survival.

  16. Discovery Radiomics for Multi-Parametric MRI Prostate Cancer Detection

    E-Print Network [OSTI]

    Chung, Audrey G; Kumar, Devinder; Khalvati, Farzad; Haider, Masoom A; Wong, Alexander

    2015-01-01

    Prostate cancer is the most diagnosed form of cancer in Canadian men, and is the third leading cause of cancer death. Despite these statistics, prognosis is relatively good with a sufficiently early diagnosis, making fast and reliable prostate cancer detection crucial. As imaging-based prostate cancer screening, such as magnetic resonance imaging (MRI), requires an experienced medical professional to extensively review the data and perform a diagnosis, radiomics-driven methods help streamline the process and has the potential to significantly improve diagnostic accuracy and efficiency, and thus improving patient survival rates. These radiomics-driven methods currently rely on hand-crafted sets of quantitative imaging-based features, which are selected manually and can limit their ability to fully characterize unique prostate cancer tumour phenotype. In this study, we propose a novel \\textit{discovery radiomics} framework for generating custom radiomic sequences tailored for prostate cancer detection. Discover...

  17. Pre-counseling Education for Low Literacy Women at Risk of Hereditary Breast and Ovarian Cancer (HBOC): Patient Experiences Using the Cancer Risk Education Intervention Tool (CREdIT)

    E-Print Network [OSTI]

    2010-01-01

    history of breast or ovarian cancer. JAMA, 293, Axilbund, J.131–136. Healthwise (2007) Ovarian cancer: Should I have myremoved to prevent ovarian cancer? Accessed January 14,

  18. Decreased expression of RNA interference machinery, Dicer and Drosha, is associated with poor outcome in ovarian cancer patients

    E-Print Network [OSTI]

    Merritt, William M.

    2009-01-01

    Molecular determinants of ovarian cancer plasticity. Am Jsmall interfering RNA on ovarian cancer cell growth. Journalwith Poor Outcome in Ovarian Cancer Patients William M.

  19. Identifying gaps in breast cancer research: Addressing disparities and the roles of the physical and social environment

    E-Print Network [OSTI]

    2007-01-01

    Physical Environment and Breast Cancer Overarching Issues A.II: Disparities in Breast Cancer: Domains of Individual-Environmental pollutants and breast cancer. Environ Health

  20. Prediction of Breast Cancer Biopsy Outcomes Using a Distributed Genetic Programming Approach

    E-Print Network [OSTI]

    Ludwig, Simone

    Prediction of Breast Cancer Biopsy Outcomes Using a Distributed Genetic Programming Approach Simone@cs.usask.ca ABSTRACT Worldwide, breast cancer is the second most common type of can- cer after lung cancer and the fifth most common cause of cancer death. In 2004, breast cancer caused 519,000 deaths worldwide

  1. The Statewide Cancer Prevention and Control Program (CPCP) was the first formal collaboration between the South Carolina Cancer Center and the Hollings Cancer

    E-Print Network [OSTI]

    Almor, Amit

    collaboration between the South Carolina Cancer Center and the Hollings Cancer Center at the Medical University of South Carolina in Charleston. The CPCP stems from an initiative of Dr. James R. Hebert who, working the ground up. Dr. Hebert is now the Director of the South Carolina Statewide CPCP Currently, the CPCP

  2. Dark matter as a cancer hazard

    E-Print Network [OSTI]

    Chashchina, Olga

    2015-01-01

    We comment on the paper "Dark Matter collisions with the Human Body" by K.~Freese and C.~Savage (Phys.\\ Lett.\\ B {\\bf 717}, 25 (2012) [arXiv:1204.1339]) and describe a dark matter model for which the results of the previous paper do not apply. Within this mirror dark matter model, potentially hazardous objects, mirror micrometeorites, can exist potentially leading to diseases triggered by multiple mutations, such as cancer.

  3. Dark matter as a cancer hazard

    E-Print Network [OSTI]

    Olga Chashchina; Zurab Silagadze

    2015-09-17

    We comment on the paper "Dark Matter collisions with the Human Body" by K.~Freese and C.~Savage (Phys.\\ Lett.\\ B {\\bf 717}, 25 (2012) [arXiv:1204.1339]) and describe a dark matter model for which the results of the previous paper do not apply. Within this mirror dark matter model, potentially hazardous objects, mirror micrometeorites, can exist potentially leading to diseases triggered by multiple mutations, such as cancer.

  4. Compositions and methods for cancer treatment using targeted carbon nanotubes

    DOE Patents [OSTI]

    Harrison, Jr., Roger G; Resasco, Daniel E; Neves, Luis Filipe Ferreira

    2013-08-27

    The present invention is a method for detecting and destroying cancer tumors. The method is based on the concept of associating a linking protein or linking peptide such as, but not limited to, annexin V or other annexins to carbon nanotubes such as single-walled carbon nanotubes (SWNTs) to form a protein-CNT complex. Said linking protein or peptide can selectively bind to cancerous cells, especially tumor vasculature endothelial cells, rather than to healthy ones by binding to cancer-specific external receptors such as anionic phospholipids including phosphatidylserine expressed on the outer surfaces of cancer cells only. Irradiation of bound CNTs with one or more specific electromagnetic wavelengths is then used to detect and destroy those cells to which the CNTs are bound via the linking protein or peptide thereby destroying the tumor or cancer cells and preferably an immunostimulant is provided to the patient to enhance the immune response against antigens released from the tumor or cancer cells.

  5. Translating the cancer genome: Going beyond p values

    SciTech Connect (OSTI)

    Chin, Lynda; Chin, Lynda; Gray, Joe W.

    2008-04-03

    Cancer cells are endowed with diverse biological capabilities driven by myriad inherited and somatic genetic and epigenetic aberrations that commandeer key cancer-relevant pathways. Efforts to elucidate these aberrations began with Boveri's hypothesis of aberrant mitoses causing cancer and continue today with a suite of powerful high-resolution technologies that enable detailed catalogues of genomic aberrations and epigenomic modifications. Tomorrow will likely bring the complete atlas of reversible and irreversible alteration in individual cancers. The challenge now is to discern causal molecular abnormalities from genomic and epigenomic 'noise', to understand how the ensemble of these aberrations collaborate to drive cancer pathophysiology. Here, we highlight lessons learned from now classical examples of successful translation of genomic discoveries into clinical practice, lessons that may be used to guide and accelerate translation of emerging genomic insights into practical clinical endpoints that can impact on practice of cancer medicine.

  6. Genome Science and Personalized Cancer Treatment (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Gray, Joe

    2011-04-28

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

  7. Genetic heterogeneity in breast cancer: the road to personalised medicine?

    E-Print Network [OSTI]

    Baird, Richard D.; Caldas, Carlos

    2013-06-18

    , Alipaz J, Bauer MJ, Beare D, Butler A, Carter RJ, Chen L, Cox AJ, Edkins S, Kokko- Gonzales PI, Gormley NA, Grocock RJ, Haudenschild CD, Hims MM, James T, Jia M, Kingsbury Z, Leroy C, Marshall J, Menzies A, et al: A comprehensive catalogue of somatic... . Keywords: Breast cancer, Next-generation sequencing, W Personalized medicine, Heterogeneity The genetic heterogeneity seen in breast cancer has important clinical implications In 2008 it was estimated that the annual number of new breast cancer diagnoses...

  8. Genome Science and Personalized Cancer Treatment (LBNL Summer Lecture Series)

    SciTech Connect (OSTI)

    Gray, Joe

    2009-08-04

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks — particularly with regard to breast cancer.

  9. The impact of cancer on the neural activity

    E-Print Network [OSTI]

    Iarosz, Kelly Cristiane; Baptista, Murilo da Silva; Protachevicz, Paulo Ricardo

    2015-01-01

    We study the impact of the decrease in the neural population on the neuronal firing rate. We propose a cellular automaton model from cancerous growth in a brain tissue and the death of neurons due absence of cells that help support to neurons. We use this model to study how the firing rate changes when the neuronal networks is under different external stimuli and the cancerous cells have different proliferation rate. Our work shows that the cancer proliferation decreases the neuronal firing rate.

  10. MicroRNA signature of cis-platin resistant vs. cis-platin sensitive ovarian cancer cell lines

    E-Print Network [OSTI]

    Kumar, Smriti R.

    Background: Ovarian cancer is the leading cause of death from gynecologic cancer in women worldwide. According to the National Cancer Institute, ovarian cancer has the highest mortality rate among all the reproductive ...

  11. Lymphedema in Breast Cancer Survivors : : Risk Factors, Distress and Quality of Life, and Patient Compliance with a Physician Referral

    E-Print Network [OSTI]

    Dominick, Sally Ann

    11 to 20 nodes ? 21 nodes Breast Cancer Surgery Lumpectomy/Mastectomies Time since Breast Cancer Surgery, yearsKahn KL. Arm edema in breast cancer patients. J Natl Cancer

  12. Development of alternating amphiphilic copolymers for targeted delivery applications in cancer

    E-Print Network [OSTI]

    Brower, Kevin P. (Kevin Peter)

    2011-01-01

    According to the American Cancer Society, approximately 1,479,000 new cases of cancer were expected to be diagnosed, while 562,340 Americans were expected to die from cancer in 2009 alone. Even though advances in early ...

  13. Potential for Cardiovascular Exercise Dosing to Improve Cardiorespiratory Fitness in Breast Cancer Survivors

    E-Print Network [OSTI]

    Burnett, Dave

    2013-05-31

    With an increase in early detection and curative treatment for breast cancer, there is a growing number of breast cancer survivors. Cancer survivors are at greater risk than their age matched peers for long-term health ...

  14. The shared experience of adolescent and young adult cancer patients and their caregivers

    E-Print Network [OSTI]

    Juth, V; Silver, RC; Sender, L

    2015-01-01

    young adult survivors of childhood cancer. Oncology Nursingadults with cancer. Journal of Pediatric Oncology Nursing,adults with cancer: Comparing the findings from two qualitative studies. European Journal of Oncology Nursing,

  15. A theory of the cancer age-specific incidence data based on extreme value distributions

    E-Print Network [OSTI]

    Soto-Ortiz, Luis; Brody, James P

    2012-01-01

    2011). 7 P. Armitage and R. Doll, Br J Cancer 8, 1 (1954). 8P. Armitage and R. Doll, Br J Cancer 91, 1983 (2004). 9 E.10 P. Armitage and R. Doll, Br J Cancer 11, 161 (1957). 11

  16. Cancer survivors and survivorship care: Provider expectations, post-treatment health services, and patient reported outcomes

    E-Print Network [OSTI]

    Hahn, Erin Elizabeth

    2013-01-01

    2011) Long Term Effects and Cancer Survivorship in the OlderGanz (Eds. ), Management of Cancer for the Older Patient (the Quality of Care for Cancer Survivors. Psycho-Oncology (

  17. Cancer Prognosis Through Gene Expression Analysis Steven Buechler, Applied and Computational Mathematics and Statistics,

    E-Print Network [OSTI]

    Buechler, Steven

    Cancer Prognosis Through Gene Expression Analysis Steven Buechler, Applied the breast cancer patients who can avoid chemotherapy without increasing the risk of recurrence. Background. Following the initial surgery, many breast cancer patients

  18. Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer

    E-Print Network [OSTI]

    2007-01-01

    transcription in serous ovarian cancers; prognostic markersnumber changes at 8q24 in ovarian cancer cell lines. Table 2cells Table S1 List of ovarian cancer cell lines used in the

  19. Are ABCB1 (P-glycoprotein) polymorphisms clinically relevant in ovarian cancer? - Finally an Answer!

    E-Print Network [OSTI]

    Konecny, GE

    2013-01-01

    of MDR1 in epithelial ovarian cancer and its associationnucleotide polymorphisms in ovarian cancer tissue: G2677T/Atherapy in advanced ovarian cancer. Anticancer Res 2006;26:

  20. Estrogen withdrawal, increased breast cancer risk and the KRAS-variant

    E-Print Network [OSTI]

    2015-01-01

    menopausal women 3 and ovarian cancer. 4-6 The KRAS-variantvariant patients with ovarian cancer or head and neck cancerincluding breast and ovarian cancer, as well as a third

  1. Recent breast cancer incidence trends according to hormone therapy use: the California Teachers Study cohort

    E-Print Network [OSTI]

    2010-01-01

    European populations. Breast Cancer Res Treat 2008, 107:389-as: Marshall et al. : Recent breast cancer incidence trendsTeachers Study cohort. Breast Cancer Research 2010 12:R4.

  2. PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer

    E-Print Network [OSTI]

    Wishart, Gordon C.; Azzato, Elizabeth M.; Greenberg, David C.; Rashbass, Jem; Kearins, Olive; Lawrence, Gill; Caldas, Carlos; Pharoah, Paul D. P.

    2010-01-06

    Abstract Introduction The aim of this study was to develop and validate a prognostication model to predict overall and breast cancer specific survival for women treated for early breast cancer in the UK. Methods Using the Eastern Cancer Registration...

  3. Breast cancer screening disparities among ethnically diverse women in California : a latent profile analysis

    E-Print Network [OSTI]

    Gerry, Arianna Aldridge

    2011-01-01

    treatment of primary breast cancer: A systematic review.Perceived risk of breast cancer among women at average and2003). Nutrition and breast cancer. Breast, 12, 412-416.

  4. Unraveling the microenvironmental influences on the normal mammary gland and induction and progression of breast cancer

    E-Print Network [OSTI]

    Weigelt, Britta

    2009-01-01

    hollow lumen. (right) Breast cancer cells form disorganizedFig. 2. Morphologies of breast cancer cell lines cultured inof 4 representative breast cancer cell lines cultured as 2D

  5. Breast Cancer Protein Scrutinized -Softpedia http://news.softpedia.com/news/Breast-Cancer-Protein-Scrutinized-153216.shtml[8/24/2010 4:07:21 PM

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Breast Cancer Protein Scrutinized - Softpedia http://news.softpedia.com/news/Breast-Cancer >> Home > News > Science > Microbiology/Genetics Microbiology/Genetics Breast Cancer Protein Scrutinized the development of new diagnosis and treatment methods for breast cancer, researchers managed to study in depth

  6. 7/3/13 3:01 PMBreast-cancer protein purified Page 2 of 5http://www.news.chauthiduniya.com/breast-cancer-protein-purified

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    7/3/13 3:01 PMBreast-cancer protein purified Page 2 of 5http://www.news.chauthiduniya.com/breast-cancer-protein-purified Health & Yoga Breast-cancer protein purified Share This Tags BREAST CANCERproteinpurified TweetTweet 0 Like 0 submit StumbleUpon London: Scientists have purified the protein produced by the breast cancer

  7. High-dose-rate brachytherapy as monotherapy for prostate cancer

    E-Print Network [OSTI]

    Demanes, DJ; Ghilezan, MI

    2014-01-01

    comparison with HDR brachytherapy and preliminary clinicalrisk prostate cancer. Brachytherapy 2013;12:428e433.Demanes, M.I. Ghilezan / Brachytherapy 13 (2014) 529e541

  8. Nanotechnology in Head and Neck Cancer: The Race Is On

    E-Print Network [OSTI]

    El-Sayed, Ivan H.

    2010-01-01

    10.1007/s11912-010-0087-2 Nanotechnology in Head and Neckthe applications of nanotechnology in head and neck cancer,plasmonic gold nanotechnology. Keywords Nanotechnology .

  9. Ancient Proteins Help Unravel a Modern Cancer Drug's Mechanism

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    homologous protein kinases found in normal, healthy cells. It has been widely used to fight colon cancers and chronic myeloid leukemia. The protein kinase Abl is involved in...

  10. Yeast-based vaccine approaches to cancer immunotherapy

    E-Print Network [OSTI]

    Howland, Shanshan W

    2008-01-01

    Saccharomyces cerevisiae stimulates dendritic cells and represents a promising candidate for cancer immunotherapy development. Effective cross-presentation of antigen delivered to dendritic cells is necessary for successful ...

  11. Cell Motility and Deformability in the Pathogenesis of Lung Cancer

    E-Print Network [OSTI]

    Pagano, Paul Carmelo

    2015-01-01

    25-26; Rockville, MD. Philadelphia. xviii 3. Pagano PC, etJan 6-9; San Diego, CA. Philadelphia (PA): AACR Clin Cancer

  12. Identification of cancer protein biomarkers using proteomic techniques

    DOE Patents [OSTI]

    Mor, Gil G. (Cheshire, CT); Ward, David C. (Las Vegas, NV); Bray-Ward, Patricia (Las Vegas, NV)

    2010-02-23

    The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.

  13. Insight into Alzheimer's, cancer, anemia gleaned from ribosome...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Insights from ribosome research Insight into Alzheimer's, cancer, anemia gleaned from ribosome research Groundbreaking study of the human ribosome reveals tiny molecular machine is...

  14. Protocadherin-7 induces bone metastasis of breast cancer

    SciTech Connect (OSTI)

    Li, Ai-Min; Tian, Ai-Xian; Zhang, Rui-Xue; Ge, Jie; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin ; Sun, Xuan; Cao, Xu-Chen; Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin

    2013-07-05

    Highlights: •PCDH7 is overexpression in high bone metastatic MDA-MB-231 cells. •PCDH7 is up-regulation in bone metastatic breast cancer tissues. •Suppression of PCDH7 inhibits cell proliferation, migration, and invasion in vitro. •PCDH7 induces breast cancer bone metastasis in vivo. -- Abstract: Breast cancer had a propensity to metastasize to bone, resulting in serious skeletal complications associated with poor outcome. Previous study showed that Protocadherin-7 (PCDH7) play an important role in brain metastatic breast cancer, however, the role of PCDH7 in bone metastatic breast cancer has never been explored. In the present study, we found that PCDH7 expression was up-regulation in bone metastatic breast cancer tissues by real-time PCR and immunohistochemistry assays. Furthermore, suppression of PCDH7 inhibits breast cancer cell proliferation, migration, and invasion in vitro by MTT, scratch, and transwell assays. Most importantly, overexpression of PCDH7 promotes breast cancer cell proliferation and invasion in vitro, and formation of bone metastasis in vivo. These data provide an important insight into the role of PCDH7 in bone metastasis of breast cancer.

  15. Three-Dimensional Thermal Tomography Advances Cancer Treatment...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Three-Dimensional Thermal Tomography Advances Cancer Treatment Technology available for licensing: A 3D technique to detect early skin changes due to radiation treatment in breast...

  16. Locally Advanced Prostate Cancer: Three-Dimensional Magnetic...

    Office of Scientific and Technical Information (OSTI)

    Locally Advanced Prostate Cancer: Three-Dimensional Magnetic Resonance Spectroscopy to Monitor Prostate Response to Therapy Citation Details In-Document Search Title: Locally...

  17. Radioisotopes for Medical Diagnostics and Cancer Therapy at BNL...

    Office of Science (SC) Website

    Radioisotopes for Medical Diagnostics and Cancer Therapy at BNL Nuclear Physics (NP) NP Home About Research Facilities Science Highlights Benefits of NP Applications of Nuclear...

  18. Is Primary Prostate Cancer Treatment Influenced by Likelihood...

    Office of Scientific and Technical Information (OSTI)

    Cancer Center, Chapel Hill, NC 2 ; Carpenter, William R. 4 ; Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 2 ;...

  19. From Bombs to Breast Cancer Imaging: Los Alamos National Laboratory

    SciTech Connect (OSTI)

    Martineau, Rebecca M

    2012-07-26

    In the United States, one in eight women will be affected by breast cancer. According to the American Cancer Society, breast cancer is the most commonly diagnosed - as well as the second most fatal - cancer in American women. It is estimated that there will be nearly 200,000 diagnoses of breast cancer this year; more than 40,000 of these will be fatal. Although advances in medical technologies have greatly increased the odds of surviving the disease, the increase in screenings has not resulted in a significant reduction in the breast cancer mortality rate. Moreover, recent studies have even suggested that an increase in these methods might, in itself, cause cancer. A new tool for early detection and diagnosis of breast cancer, supported by an award from the Breast Cancer Research Program (BCRP) of the Congressionally Directed Medical Research Programs of Department of Defense, could give women a new advantage in the fight against breast cancer. This LANL-led project will integrate ultrasound tomography (UST) with recent discoveries in the field of cell and tissue biomechanics to improve breast cancer detection and characterization. UST uses ultrasound waves instead of X-rays to identify and characterize breast tumors. This technology reveals small mechanical-property changes within the breast. These changes are often the earliest signs of breast cancer. Additionally, UST is effective for women with dense breast tissue, who have a higher risk of developing breast cancer. Because the technology does not use radiation, UST can also be used as frequently as needed for women with a high risk of developing breast cancer. In contrast, mammography, the only routine breast-cancer screening tool currently available, is not effective for women with dense breast tissue and may come with unwanted side-effects caused by ionizing radiation. UST has great potential to become an alternative breast-cancer screening tool because of UST's advantages and benefits over mammography. Currently, there is fierce debate surrounding the age at which breast cancer screening should begin, and once begun, how often it should occur. The American Cancer Society recommends yearly mammograms starting at age 40. On the other hand, the U.S. Preventive Services Task Force recommends against routine so early. Rather, the Task Force recommends biennial mammography screening for women aged 50 to 74 years. The ten-year discrepancy in the onset of screening results from recent data suggesting that the frequent use of X-ray radiation during screenings could potentially increase the likelihood of developing cancer. This danger is increased by the low sensitivity and accuracy of mammograms, which sometimes require multiple screenings to yield results. Furthermore, mammograms are often not only inaccurate, but average appalling misdiagnoses rates: about 80% false positives and 15% false negatives. These misdiagnoses lead to unwarranted biopsies at an estimated health care cost of $2 billion per year, while at the same time, resulting in excessive cases of undetected cancer. As such, the National Cancer Institute recommends more studies on the advantages of types and frequency of screenings, as well as alternative screening options. The UST technology developed at LANL could be an alternative option to greatly improve the specificity and sensitivity of breast cancer screening without using ionizing radiation. LANL is developing high-resolution ultrasound tomography algorithms and a clinical ultrasound tomography scanner to conduct patient studies at the UNM Hospital. During UST scanning, the patient lies face-down while her breast, immersed in a tank of warm water, is scanned by phased-transducer arrays. UST uses recorded ultrasound signals to reconstruct a high-resolution three-dimensional image of the breast, showing the spatial distribution of mechanical properties within the breast. Breast cancers are detected by higher values of mechanical properties compared to surrounding tissues. Thus, high-resolution breast images obtained using LANL's novel UST algorithms ha

  20. 7/3/13 10:04 AM2010 Breast Cancer Highlights, Breast Cancer Research Program, Congressionally Directed Medical Research Programs Page 1 of 10http://cdmrp.army.mil/bcrp/research_highlights/2010.shtml#top

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    7/3/13 10:04 AM2010 Breast Cancer Highlights, Breast Cancer Research Program, Congressionally > Breast Cancer > Research Highlights > 2010 Breast Cancer Highlights 2010 Breast Cancer Research Highlights Successful Isolation of BRCA2 (breast cancer type 2 susceptibility protein) and Elucidation of Its

  1. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

    E-Print Network [OSTI]

    2009-01-01

    breast cancer and ovarian cancers as compared with thedence of breast and ovarian cancers, even among women whoof breast cancer and/or ovarian cancer. The current study is

  2. Breast Cancer Cells Induce Stromal Fibroblasts to Secrete ADAMTS1 for Cancer Invasion through an Epigenetic Change

    E-Print Network [OSTI]

    2012-01-01

    full- length cDNA collection using the following primers: 59-CGA TCT Co-culture of fibroblasts with cancer cells

  3. Plasma Vitamin D and Prostate Cancer Risk: Results from the Selenium and Vitamin E Cancer Prevention Trial

    E-Print Network [OSTI]

    2014-01-01

    Biomarkers & Prevention Plasma Vitamin D and Prostate Cancerfrom the Selenium and Vitamin E Cancer Prevention Trial Alanwho are using supplemental vitamin D should limit their dose

  4. The Study of Mechanical Properties of Cells as a Biomarker for Cancer Diagnostics

    E-Print Network [OSTI]

    Tse, Henry Tat Kwong

    2012-01-01

    Di Carlo, D. (2012). A Mechanical Biomarker of Cell State inusing a microfluidic device for mechanical and electricalOral Cancer Diagnosis by Mechanical Phenotyping. Cancer Res

  5. Lung Cancer (2005) 47, 41--47 Improving the specificity of fluorescence

    E-Print Network [OSTI]

    Duin, Robert P.W.

    2005-01-01

    Lung Cancer (2005) 47, 41--47 Improving the specificity of fluorescence bronchoscopy spectroscopy; Lung cancer; Bronchoscopy Summary Detection of malignancies of the bronchial tree in an early

  6. 1Q1 Esterase-activatable -lapachone prodrug micelles for NQO1-targeted 2 lung cancer therapy

    E-Print Network [OSTI]

    Gao, Jinming

    -targeted 2 lung cancer therapy 3Q2 Xinpeng Ma a,1 , Xiumei Huang b,1 , Zachary Moore b , Gang Huang lung cancer 20 Cancer nanomedicine 21Lung cancer is one of the most lethal forms of cancer and current to be highly efficacious in killing non-small cell lung 23cancer (NSCLC) cells regardless of their p53, cell

  7. Targeting NRF2 signaling for cancer chemoprevention

    SciTech Connect (OSTI)

    Kwak, Mi-Kyoung; Kensler, Thomas W.

    2010-04-01

    Modulation of the metabolism and disposition of carcinogens through induction of cytoprotective enzymes is one of several promising strategies to prevent cancer. Chemopreventive efficacies of inducers such as dithiolethiones and sulforaphane have been extensively studied in animals as well as in humans. The KEAP1-NRF2 system is a key, but not unilateral, molecular target for these chemopreventive agents. The transcription factor NRF2 (NF-E2-related factor 2) is a master regulator of the expression of a subset of genes, which produce proteins responsible for the detoxication of electrophiles and reactive oxygen species as well as the removal or repair of some of their damage products. It is believed that chemopreventive enzyme inducers affect the interaction between KEAP1 and NRF2 through either mediating conformational changes of the KEAP1 protein or activating phosphorylation cascades targeting the KEAP1-NRF2 complex. These events in turn affect NRF2 stability and trafficking. Recent advances elucidating the underlying structural biology of KEAP1-NRF2 signaling and identification of the gene clusters under the transcriptional control of NRF2 are facilitating understanding of the potential pleiotropic effects of NRF2 activators and discovery of novel classes of potent chemopreventive agents such as the triterpenoids. Although there is appropriately a concern regarding a deleterious role of the KEAP1-NRF2 system in cancer cell biology, especially as the pathway affects cell survival and drug resistance, the development and the use of NRF2 activators as chemopreventive agents still holds a great promise for protection of normal cells from a diversity of environmental stresses that contribute to the burden of cancer and other chronic, degenerative diseases.

  8. Successful management of elderly breast cancer patients treated without radiotherapy

    E-Print Network [OSTI]

    Valassiadou, Kalliope; Morgan, David A. L.; Robertson, John F. R.; Pinder, Sarah E.; Cheung, Kwok-Leung

    2007-06-03

    -three cancers were ER positive and 26 were ER negative. ER status was not recorded in four patients. Forty of the 53 ER positive patients were treated with adju- vant tamoxifen. The median size of the cancers was 19 mm (range 2 mm – 40 mm). Seventeen patients...

  9. Neural Networks for Breast Cancer Diagnosis School of Computer Science

    E-Print Network [OSTI]

    Yao, Xin

    Neural Networks for Breast Cancer Diagnosis Xin Yao School of Computer Science The University neural network based approaches to breast cancer diag- nosis, both of which have displayed good general- isation. The first approach is based on evolution- ary artificial neural networks. In this approach

  10. www.yalecancercenter.org Coping with a Breast Cancer

    E-Print Network [OSTI]

    O'Hern, Corey S.

    rates of breast cancer. However, Asians who migrate and live in the United States have a higher rate are not at risk of breast cancer. It's a very common disease and in the United States at this time almost one out the fact that the incidence has been increasing, the death rate for most of the last century has remained

  11. Method for detecting the presence of prostate cancer

    DOE Patents [OSTI]

    Karin, Michael; Luo, Jun-Li; Tan, Wei

    2010-04-13

    The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-.alpha. (IKK.alpha.) and the IKK.alpha.-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.

  12. Berkeley Lab Scientist Co-Leads Breast Cancer Dream Team

    ScienceCinema (OSTI)

    Gray, Joe

    2013-05-29

    An $16.5 million, three-year grant to develop new and more effective therapies to fight breast cancer was awarded today to a multi-institutional Dream Team of scientists and clinicians that is co-led by Joe Gray, a renowned cancer researcher with the U.S. Department of Energys Lawrence Berkeley National Laboratory. http://newscenter.lbl.gov/

  13. Method for restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, Mina J. (Berkeley, CA); Weaver, Valerie M. (Oakland, CA)

    2000-01-01

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

  14. Recent Progress in Ultra-Wideband Microwave Breast Cancer Detection

    E-Print Network [OSTI]

    Coates, Mark

    were diagnosed in the United States and Canada ­ with as many as 45,000 cases leading to death. For women, breast cancer mortality rates are higher than for any other cancer, with the exception of lung as early as possible. This will not only reduce mortality and incidence rates, but also significantly ease

  15. Lung Cancer and Arsenic Concentrations in Drinking Water in Chile

    E-Print Network [OSTI]

    California at Berkeley, University of

    Lung Cancer and Arsenic Concentrations in Drinking Water in Chile Catterina Ferreccio,1,2 Claudia- trations have since been reduced to 40 g/liter. We investi- gated the relation between lung cancer and arsenic in drinking water in northern Chile in a case-control study involving patients diagnosed with lung

  16. Investigating the initiation and progression of small cell lung cancer

    E-Print Network [OSTI]

    Brauneis, Alison Dooley

    2011-01-01

    Small cell lung cancer (SCLC) comprises 18% of all lung cancer cases and is an aggressive disease with a five-year survival rate of less than 5%, mainly due to the advanced nature of the disease at the time of diagnosis. ...

  17. Therapeutics, Targets, and Chemical Biology Prostate Cancer Radiosensitization through

    E-Print Network [OSTI]

    Gao, Jinming

    in the United States. It occurs with the highest inci- dence (25%) of all cancers and is the second leading, which were associated with ATP loss and induction of -calpain­induced programmed cell death cause of cancer-related death in men (1). Radiation therapy [X-ray therapy (XRT)] using fractionated low

  18. Berkeley Lab Scientist Co-Leads Breast Cancer Dream Team

    SciTech Connect (OSTI)

    Gray, Joe

    2009-01-01

    An $16.5 million, three-year grant to develop new and more effective therapies to fight breast cancer was awarded today to a multi-institutional Dream Team of scientists and clinicians that is co-led by Joe Gray, a renowned cancer researcher with the U.S. Department of Energys Lawrence Berkeley National Laboratory. http://newscenter.lbl.gov/

  19. Cancer evolution: mathematical models and computational inference

    E-Print Network [OSTI]

    Beerenwinkel, Niko; Schwarz, Roland F.; Gerstung, Moritz; Markowetz, Florian

    2014-10-07

    and the presence of mutator phenotypes make it challenging to separate driver from passenger mutations. To identify genes under positive somatic selection, one can detect an excess of nonsynonymous somatic mutations, that is, a high dN/dS ratio, in cancer genome... sequences. The same genes are often under purifying selection in intergenerational terms leading to a depletion of nonsynonymous polymorphisms in the human population. Based on the idea of a high somatic dN/dS, (Greenman et al. (2006)) formulated a...

  20. Using HEP Technology to Fight Cancer

    SciTech Connect (OSTI)

    Le Du, Patrick

    2004-06-30

    Many engineering and physics HEP groups are now collaborating with medical doctors and biomedical scientists to develop new modern and 'state of the art' radiation instruments for cancer diagnostics and treatment. This presentation will review some of these studies, oriented towards the imaging fields for diagnostic (Positron Emission Tomography and Computed Tomography) and particle therapy for tumor treatment (from proton to light ions). I will try, using appropriate examples, to show what are the challenges and where the development of HEP concepts, tools and techniques can be used.

  1. Laser research shows promise for cancer treatment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Homesum_a_epg0_fpd_mmcf_m.xls" ,"Available from WebQuantity ofkandz-cm11 Outreach Home Room NewsInformationJesse Bergkamp Graduate studentScienceLaboratoryandBryanoutreachCancer treatment

  2. BRCA1-linked marker in postmenopausal breast cancer families

    SciTech Connect (OSTI)

    Folsom, A.R.; Chen, P.L.; Sellers, T.A.

    1994-09-01

    A majority of breast and ovarian cancer families and half of the early-onset breast cancer families are linked to markers on 17q (BRCA1). While linkage has been demonstrated in families with premenopausal disease, few studies have tested these markers in families with postmenopausal breast cancer. In the Iowa Women`s Health Study, a population-based study of over 42,000 women, an association of waist-to-hip ratio (WHR) with the risk of postmenopausal breast cancer was found predominantly in women with a positive family history -- this interaction was associated with a 3.2-fold elevated risk. This effect was even more pronounced when the definition of family history included breast and ovarian cancer, known to be linked to 17q markers. We evaluated evidence for linkage with D17S579, a BRCA-1-linked marker, in 13 families in which the index case had postmenopausal breast cancer. Genotyping for alleles at D17S579 was performed on 84 blood samples. Linkage analysis assumed that the breast cancer trait had an autosomal dominant mode of inheritance with a penetrance of 80%. For the 13 families studied, the maximum lod score was 0.29 at a theta of 0.27. There was significant evidence against tight linkage of breast cancer with D17S579 (theta<0.4). Heterogeneity analysis suggested evidence for the presence of both linked and unlinked families. Partitioning informative families on WHR of the index case suggested heterogeneity. These data suggest that, in a subset of families identified by a postmenopausal breast cancer proband, risk of breast cancer may be mediated by BRCA1, with heterogeneity defined by WHR.

  3. P/1WINTER 2014 Welcome to the Winter 2014 issue of the Stanford Cancer

    E-Print Network [OSTI]

    Puglisi, Joseph

    P/1WINTER 2014 Welcome to the Winter 2014 issue of the Stanford Cancer Institute Clinical Research, and especially physicians who are considering treatment options for their patients with cancer, about clinical trials and programs available at the Stanford Cancer Institute. We have more than 300 cancer clinical

  4. Ref: 13/133 10 July 2013 New hope in the fight against childhood cancer

    E-Print Network [OSTI]

    Molinari, Marc

    Ref: 13/133 10 July 2013 New hope in the fight against childhood cancer Cancer Research UK bring treatments for a particular aggressive form of childhood cancer closer to reality. Researchers in the immune system, potentially heightening the body's own immune response to cancer. Published in the July

  5. National Cancer Institute at the National Institutes of Health Posted: 02/09/2012

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    National Cancer Institute at the National Institutes of Health Posted: 02/09/2012 NCI Cancer Center and copying are strongly linked to cancer, birth defects and other problems. Click here to read full press 66 as Cancer Centers. Largely based in research universities, these facilities are home to many

  6. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer

    E-Print Network [OSTI]

    Cai, Long

    Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer, Timothy Anderson6, Norman Gerry7, Joseph Keane4, Marc E Lenburg7 & Jerome S Brody1 Lung cancer smokers with suspicion of lung cancer could be used as a lung cancer biomarker. Using a training set (n

  7. Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 19952007 (the

    E-Print Network [OSTI]

    Maizels, Rick

    1 Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995­2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data M P Coleman Background Cancer survival is a key measure of the effectiveness of health-care systems. Persistent regional

  8. Skin Cancer: A Young Person's Disease By Lauren Duffy (B.S. Communication, Journalism '14)

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Skin Cancer: A Young Person's Disease By Lauren Duffy (B.S. Communication, Journalism '14 is that this behavior is extremely unhealthy and risky for their bodies, specifically their skin. Skin cancer is the most common form of cancer found in young adults and second most common cancer found in adolescents

  9. Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and

    E-Print Network [OSTI]

    Rosenberg, Michael S.

    Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and geographic We have previously shown that geographic differences in cancer mortalities in Europe are related of 45 male and 47 female cancers. Differences in cancer incidences are correlated moder- ately, first

  10. http://arXiv.org/abs/physics/0011002 A HISTORICAL PERSPECTIVE ON CANCER *

    E-Print Network [OSTI]

    Sorkin, Rafael Dolnick

    http://arXiv.org/abs/physics/0011002 A HISTORICAL PERSPECTIVE ON CANCER * Rafael D. Sorkin@physics.syr.edu Abstract It is proposed that cancer results from the breakdown of universal con­ trol mechanisms which the damaged control mechanisms and thereby arresting the cancer. More or less by definition, a cancerous cell

  11. http://arXiv.org/abs/physics/0011002 A HISTORICAL PERSPECTIVE ON CANCER *

    E-Print Network [OSTI]

    Sorkin, Rafael Dolnick

    http://arXiv.org/abs/physics/0011002 A HISTORICAL PERSPECTIVE ON CANCER * Rafael D. Sorkin@physics.syr.edu Abstract It is proposed that cancer results from the breakdown of universal con- trol mechanisms which the damaged control mechanisms and thereby arresting the cancer. More or less by definition, a cancerous cell

  12. Cancer classification by gradient LDA technique using microarray gene expression data

    E-Print Network [OSTI]

    Cancer classification by gradient LDA technique using microarray gene expression data Alok Sharma a) Dimensionality reduction Cancer classification Feature selection Feature extraction a b s t r a c t Cancer techniques are applied for cancer classification, they face the small sample size (SSS) problem of gene

  13. TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk factors

    E-Print Network [OSTI]

    TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk mutations are observed in about 40e70% of lung cancer tissues, and the hot spot codon mu- tations factors that influence TP53 gene mutation in lung cancer patients residing areas with high lung cancer

  14. QCL-based TDLAS sensor for detection of NO toward emission measurements from ovarian cancer cells

    E-Print Network [OSTI]

    QCL-based TDLAS sensor for detection of NO toward emission measurements from ovarian cancer cells M. On the other hand, high concentra- tions of NO can suppress tumor growth [4­7]. Ovarian cancer is the leading cause of gynecological cancer-related deaths, and *14,270 US women will die of ovarian cancer in 2014 [8

  15. Letter to the Editor Molecular profiling of platinum resistant ovarian cancer: Use of the

    E-Print Network [OSTI]

    Letter to the Editor Molecular profiling of platinum resistant ovarian cancer: Use of the model to predict platin resistance in ovarian cancer. The authors studied a training set obtained from 24 tumours. Molecular profiling of platinum resistant ovar- ian cancer. Int J Cancer 2005;118:1963­71. 2. Thigpen T

  16. Targeting Adenovirus to the Serotype 3 Receptor Increases Gene Transfer Efficiency to Ovarian Cancer Cells1

    E-Print Network [OSTI]

    Hemminki, Akseli

    of receptor expression and infectivity by Ad, a panel of ovarian cancer cell lines and purified primary cancer displays enhanced infectivity for ovarian cancer cell lines and purified primary tumor cells, which could translate into increased efficacy in clinical trials. INTRODUCTION Epithelial ovarian cancer is the leading

  17. Computer-aided identification of ovarian cancer in confocal microendoscope images

    E-Print Network [OSTI]

    Gmitro, Arthur F.

    Computer-aided identification of ovarian cancer in confocal microendoscope images Saurabh of ovarian cancer is introduced. The cellular-level struc- ture present in ex vivo confocal microendoscope, 2008. 1 Introduction Ovarian cancer is the fifth most common cancer in women. According to statistics

  18. Learning Causal Models for Noisy Biological Data Mining: An Application to Ovarian Cancer Detection

    E-Print Network [OSTI]

    Tan, Ah-Hwee

    Learning Causal Models for Noisy Biological Data Mining: An Application to Ovarian Cancer Detection and accounts for their un- certainties during diagnosis. An application to the problem of ovarian cancer) describe a technique that could identify ovarian cancer patients with perfect sensitivity (cancer

  19. Strategies to Accomplish Targeted Expression of Transgenes in Ovarian Cancer for Molecular Therapeutic Applications1

    E-Print Network [OSTI]

    Hemminki, Akseli

    Strategies to Accomplish Targeted Expression of Transgenes in Ovarian Cancer for Molecular therapy of ovarian cancer. Experimental Design: Established and primary ovarian cancer and mesothelial: Consistent activation of the MK and cox-2 promoters was noted in all of the ovarian cancer cell lines

  20. Cancer Therapy: Preclinical Modulating Endogenous NQO1 Levels Identifies Key Regulatory

    E-Print Network [OSTI]

    Gao, Jinming

    Pancreatic cancer is the fourth leading cause of cancer- related death in the United States. (1). Current cancer is the fourth leading cause of cancer-related deaths, in which the 5-year survival rate is less. Results: b-Lap­mediated cell death required $90 enzymatic units of NQO1. Essential downstream mediators

  1. Therapeutic Discovery ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer

    E-Print Network [OSTI]

    Kenny, Paraic

    Therapeutic Discovery ORAI1-Mediated Calcium Influx in Lactation and in Breast Cancer Damara Mc and pumps are a key feature of some cancers, including breast cancer, understanding these calcium influx Orai1, activated by Stim2. Breast cancer cell lines had increased levels of ORAI1. ORAI1 si

  2. Systemic efficacy of oncolytic adenoviruses in imagable orthotopic models of hormone refractory metastatic breast cancer

    E-Print Network [OSTI]

    Hemminki, Akseli

    metastatic breast cancer Tuuli Ranki1,2,3 , Merja Sarkioja1,2,3 , Tanja Hakkarainen1,2,3 , Karl von Smitten4- fractory to current treatments, such as hormone refractory meta- static breast cancer. In clinical cancer several capsid-modified oncolytic adenoviruses for the treatment of breast cancer with and without Kupffer

  3. EPIDEMIOLOGY Global and focal brain volume in long-term breast cancer

    E-Print Network [OSTI]

    van Vliet, Lucas J.

    EPIDEMIOLOGY Global and focal brain volume in long-term breast cancer survivors exposed to adjuvant of non-CNS directed chemotherapy-exposed breast cancer survivors, on average 21 years post chemotherapy-exposed breast cancer patients, mean age 64.0 (SD = 6.5) years, who had been diagnosed with cancer

  4. An ex vivo co-culture model system to evaluate stromalepithelial interactions in breast cancer

    E-Print Network [OSTI]

    Cheng, Ji-Xin

    An ex vivo co-culture model system to evaluate stromal­epithelial interactions in breast cancer T, Purdue University, West Lafayette, IN Breast cancer is the most commonly diagnosed cancer among women worldwide. High breast cancer incidence and mortality rates, especially in obese patients, emphasize

  5. Aging Impacts Transcriptome but not Genome of Hormone-dependentBreast Cancers

    SciTech Connect (OSTI)

    Yau, Christina; Fedele, Vita; Roydasgupta, Ritu; Fridlyand, Jane; Hubbard, Alan; Gray, Joe W.; Chew, Karen; Dairkee, Shanaz H.; Moore, DanH.; Schittulli, Francesco; Tommasi, Stefania; Paradiso, Angelo; Albertson, Donna G.; Benz, Christopher C.

    2007-10-09

    Age is one of the most important risk factors for human malignancies, including breast cancer; in addition, age-at-diagnosis has been shown to be an independent indicator of breast cancer prognosis. However, except for inherited forms of breast cancer, there is little genetic or epigenetic understanding of the biological basis linking aging with sporadic breast cancer incidence and its clinical behavior.

  6. Geranylgeranylacetone inhibits ovarian cancer progression in vitro and in vivo

    SciTech Connect (OSTI)

    Hashimoto, Kae; Morishige, Ken-ichirou . E-mail: mken@gyne.med.osaka-u.ac.jp; Sawada, Kenjiro; Ogata, Seiji; Tahara, Masahiro; Shimizu, Shoko; Sakata, Masahiro; Tasaka, Keiichi; Kimura, Tadashi

    2007-04-27

    Geranylgeranylacetone (GGA), an isoprenoid compound, is an anti-ulcer drug developed in Japan. In our previous study, GGA was shown to inhibit ovarian cancer invasion by attenuating Rho activation [K. Hashimoto, K. Morishige, K. Sawada, M. Tahara, S. Shimizu, M. Sakata, K. Tasaka, Y. Murata, Geranylgeranylacetone inhibits lysophosphatidic acid-induced invasion of human ovarian carcinoma cells in vitro. Cancer 103 (2005) 1529-1536.]. In the present study, GGA treatment inhibited ovarian cancer progression in vitro and suppressed the tumor growth and ascites in the in vivo ovarian cancer model. In vitro analysis, treatment of cancer cells by GGA resulted in the inhibition of cancer cell proliferation, the inactivation of Ras, and the suppression of tyrosine phosphorylation of mitogen-activated protein kinase (MAPK). In conclusion, this is the first report that GGA inhibited ovarian cancer progression and the anti-tumor effect by GGA is, at least in part, derived not only from the suppression of Rho activation but also Ras-MAPK activation.

  7. Practice Patterns of Radiotherapy in Cervical Cancer Among Member Groups of the Gynecologic Cancer Intergroup (GCIG)

    SciTech Connect (OSTI)

    Gaffney, David K. . E-mail: david.gaffney@hci.utah.edu; Du Bois, Andreas; Narayan, Kailash; Reed, Nick; Toita, Takafumi; Pignata, Sandro; Blake, Peter; Portelance, Lorraine; Sadoyze, Azmat; Poetter, Richard; Colombo, Alessandro; Randall, Marcus; Mirza, Mansoor R.; Trimble, Edward L.

    2007-06-01

    Purpose: The aim of this study was to describe radiotherapeutic practice of the treatment of cervical cancer in member groups of the Gynecologic Cancer Intergroup (GCIG). Methods and Materials: A survey was developed and distributed to the members of the GCIG focusing on details of radiotherapy practice. Different scenarios were queried including advanced cervical cancer, postoperative patients, and para-aortic-positive lymph node cases. Items focused on indications for radiation therapy, radiation fields, dose, use of chemotherapy, brachytherapy and others. The cooperative groups from North America were compared with the other groups to evaluate potential differences in radiotherapy doses. Results: A total of 39 surveys were returned from 13 different cooperative groups. For the treatment of advanced cervical cancer, external beam pelvic doses and total doses to point A were 47 + 3.5 Gy (mean + SD) and 79.1 + 7.9 Gy, respectively. Point A doses were not different between the North American cooperative groups compared with the others (p = 0.103). All groups used concomitant chemotherapy, with 30 of 36 respondents using weekly cisplatin. Of 33 respondents, 31 intervened for a low hemoglobin level. For a para-aortic field, the upper border was most commonly (15 of 24) at the T12-L1 interspace. Maintenance chemotherapy (after radiotherapy) was not performed by 68% of respondents. For vaginal brachytherapy after hysterectomy, 23 groups performed HDR brachytherapy and four groups used LDR brachytherapy. In the use of brachytherapy, there was no uniformity in dose prescription. Conclusions: Radiotherapy practices among member groups of the GCIG are similar in terms of both doses and use of chemotherapy.

  8. Cancer survival: global variation and long-term trends

    E-Print Network [OSTI]

    Lyratzopoulos, Georgios

    2015-03-03

    diagnosed with breast cancer between 2005 and 2009, net 5-year survival exceeded 80% in most developed countries, but was probably lower than 60% in Algeria, South Africa, Mongolia, and Jordan.1 Considering the overall number of potentially avoidable years... statistics, 2014. CA Cancer J. Clin. 64, 9–29 (2014). 8. De Angelis, R. et al. Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE--5-a population-based study. Lancet Oncol. 15, 23–34 (2014). 9. Perme, M. P., Stare, J. & Estève, J...

  9. The Kauai Skin Cancer Study--1983 to 1992

    SciTech Connect (OSTI)

    Reizner, G.T. )

    1993-05-01

    The Kauai Skin Cancer Study began as a modest effort in 1983 to look at this island's skin cancer incidence. David Elpern MD, Kauai's only dermatologist at the time, was interested in the large number of these tumors in his practice. He first enlisted his office staff to help keep track of the numbers and type of these skin cancers. Along with this information, the basic demographic data on each patient was collected. These records became the first entries into what has become a decade-long project.

  10. STAT3 regulated ARF expression suppresses prostate cancer metastasis

    E-Print Network [OSTI]

    Pencik, Jan; Schlederer, Michaela; Gruber, Wolfgang; Unger, Christine; Walker, Steven M.; Chalaris, Athena; Marié, Isabelle J.; Hassler, Melanie R.; Javaheri, Tahereh; Aksoy, Osman; Blayney, Jaine K.; Prutsch, Nicole; Skucha, Anna; Herac, Merima; Krämer, Oliver H.; Mazal, Peter; Grebien, Florian; Egger, Gerda; Poli, Valeria; Mikulits, Wolfgang; Eferl, Robert; Esterbauer, Harald; Kennedy, Richard; Fend, Falko; Scharpf, Marcus; Braun, Martin; Perner, Sven; Levy, David E.; Malcolm, Tim; Turner, Suzanne D.; Haitel, Andrea; Susani, Martin; Moazzami, Ali; Rose-John, Stefan; Aberger, Fritz; Merkel, Olaf; Moriggl, Richard; Culig, Zoran; Dolznig, Helmut; Kenner, Lukas

    2015-01-01

    P cells due to the lack of JAK1 gene expression. Cancer Res 65, 3447-53 (2005). 32. Hedvat, M. et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell 16, 487-97 (2009). 33. Lou, W., Ni, Z., Dyer... . Nat Rev Cancer 6, 663-73 (2006). 49. Chen, Z. et al. Differential p53-independent outcomes of p19(Arf) loss in oncogenesis. Sci Signal 2, ra44 (2009). 50. Kamijo, T., Bodner, S., van de Kamp, E., Randle, D.H. & Sherr, C.J. Tumor spectrum in ARF...

  11. Radiotherapy in the management of early breast cancer

    SciTech Connect (OSTI)

    Wang, Wei

    2013-03-15

    Radiotherapy is an indispensible part of the management of all stages of breast cancer. In this article, the common indications for radiotherapy in the management of early breast cancer (stages 0, I, and II) are reviewed, including whole-breast radiotherapy as part of breast-conserving treatment for early invasive breast cancer and pre-invasive disease of ductal carcinoma in situ, post-mastectomy radiotherapy, locoregional radiotherapy, and partial breast irradiation. Key clinical studies that underpin our current practice are discussed briefly.

  12. Protein Modifications as Potential Biomarkers in Breast Cancer

    SciTech Connect (OSTI)

    Jin, Hongjun; Zangar, Richard C.

    2009-11-30

    A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry techniques have shown promise for identifying changes in PTMs. In this review, we summarize the current literature on PTMs identified in the plasma and tumor tissue of breast-cancer patients or in breast cell lines. We also discuss some of the analytical techniques currently being used to evaluate PTMs.

  13. Detection of eight BRCA1 mutations in 10 breast/ovarian cancer families, including 1 family with male breast cancer

    SciTech Connect (OSTI)

    Sruewing, J.P.; Brody, L.C.; Erdos, M.R.

    1995-07-01

    Genetic epidemiological evidence suggests that mutations in BRCA1 may be responsible for approximately one half of early onset familial breast cancer and the majority of familial breast/ovarian cancer. The recent cloning of BRCA1 allows for the direct detection of mutations, but the feasibility of presymptomatic screening for cancer susceptibility is unknown. We analyzed genomic DNA from one affected individual from each of 24 families with at least three cases of ovarian or breast cancer, using SSCP assays. Variant SSCP bands were subcloned and sequenced. Allele-specific oligonucleotide hybridization was used to verify sequence changes and to screen DNA from control individuals. Six frameshift and two missense mutations were detected in 10 different families. A frameshift mutation was detected in a male proband affected with both breast and prostate cancer. A 40-bp deletion was detected in a patient who developed intra-abdominal carcinomatosis 1 year after prophylactic oophorectomy. Mutations were detected throughout the gene, and only one was detected in more than a single family. These results provide further evidence that inherited breast and ovarian cancer can occur as a consequence of a wide array of BRCA1 mutations. These results suggests that development of a screening test for BRCA1 mutations will be technically challenging. The finding of a mutation in a family with male breast cancer, not previously thought to be related to BRCA1, also illustrates the potential difficulties of genetic counseling for individuals known to carry mutations. 37 refs., 1 fig., 1 tab.

  14. Colony-Stimulating Factor-1 Receptor Inhibition Reverses the Vascular Leakage that Causes Malignant Ascites in Late-Stage Epithelial Ovarian Cancer

    E-Print Network [OSTI]

    Moughon, Diana Louise

    2015-01-01

    HC, Ledermann JA. Ovarian cancer. The Lancet. 2014 Oct88. Quirk JT, Natarajan N. Ovarian cancer incidence in theand Treatment of Ovarian Cancer: Shifting from Early Stage

  15. A Pilot study of the Sharing Risk Information Tool (ShaRIT) for Families with Hereditary Breast and Ovarian Cancer Syndrome

    E-Print Network [OSTI]

    Kardashian, Ani; Fehniger, Julia; Creasman, Jennifer; Cheung, Eleanor; Beattie, Mary

    2012-01-01

    Hereditary Breast and Ovarian Cancer Syndrome. Hereditaryrisks of breast and ovarian cancer associated with BRCA1 orMandell JB: Breast and ovarian cancer risks due to inherited

  16. Targeted resequencing of the microRNAome and 3?UTRome reveals functional germline DNA variants with altered prevalence in epithelial ovarian cancer

    E-Print Network [OSTI]

    2015-01-01

    target for therapy in ovarian cancer. Oncogene 2012; 31:1 Agarwal R, Kaye SB. Ovarian cancer: strategies forgenetic basis of ovarian cancer and its roadmap towards a

  17. Gene expression profiles in irradiated cancer cells

    SciTech Connect (OSTI)

    Minafra, L.; Bravatà, V.; Russo, G.; Ripamonti, M.; Gilardi, M. C.

    2013-07-26

    Knowledge of the molecular and genetic mechanisms underlying cellular response to radiation may provide new avenues to develop innovative predictive tests of radiosensitivity of tumours and normal tissues and to improve individual therapy. Nowadays very few studies describe molecular changes induced by hadrontherapy treatments, therefore this field has to be explored and clarified. High-throughput methodologies, such as DNA microarray, allow us to analyse mRNA expression of thousands of genes simultaneously in order to discover new genes and pathways as targets of response to hadrontherapy. Our aim is to elucidate the molecular networks involved in the sensitivity/resistance of cancer cell lines subjected to hadrontherapy treatments with a genomewide approach by using cDNA microarray technology to identify gene expression profiles and candidate genes responsible of differential cellular responses.

  18. Intraoperative radiation therapy in recurrent ovarian cancer

    SciTech Connect (OSTI)

    Yap, O.W. Stephanie . E-mail: stbeast@stanford.edu; Kapp, Daniel S.; Teng, Nelson N.H.; Husain, Amreen

    2005-11-15

    Purpose: To evaluate disease outcomes and complications in patients with recurrent ovarian cancer treated with cytoreductive surgery and intraoperative radiation therapy (IORT). Methods and Materials: A retrospective study of 24 consecutive patients with ovarian carcinoma who underwent secondary cytoreduction and intraoperative radiation therapy at our institution between 1994 and 2002 was conducted. After optimal cytoreductive surgery, IORT was delivered with orthovoltage X-rays (200 kVp) using individually sized and beveled cone applications. Outcomes measures were local control of disease, progression-free interval, overall survival, and treatment-related complications. Results: Of these 24 patients, 22 were available for follow-up analysis. Additional treatment at the time of and after IORT included whole abdominopelvic radiation, 9; pelvic or locoregional radiation, 5; chemotherapy, 6; and no adjuvant treatment, 2. IORT doses ranged from 9-14 Gy (median, 12 Gy). The anatomic sites treated were pelvis (sidewalls, vaginal cuff, presacral area, anterior pubis), para-aortic and paracaval lymph node beds, inguinal region, or porta hepatitis. At a median follow-up of 24 months, 5 patients remain free of disease, whereas 17 patients have recurred, of whom 4 are alive with disease and 13 died from disease. Five patients recurred within the radiation fields for a locoregional relapse rate of 32% and 12 patients recurred at distant sites with a median time to recurrence of 13.7 months. Five-year overall survival was 22% with a median survival of 26 months from time of IORT. Nine patients (41%) experienced Grade 3 toxicities from their treatments. Conclusion: In carefully selected patients with locally recurrent ovarian cancer, combined IORT and tumor reductive surgery is reasonably tolerated and may contribute to achieving local control and disease palliation.

  19. Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer

    E-Print Network [OSTI]

    Faber, Anthony C.

    BH3 mimetics such as ABT-263 induce apoptosis in a subset of cancer models. However, these drugs have shown limited clinical efficacy as single agents in small-cell lung cancer (SCLC) and other solid tumor malignancies, ...

  20. Targeting nucleic acids for pancreatic cancer: disease modeling and therapy

    E-Print Network [OSTI]

    Lo, Justin Han Je

    2015-01-01

    Pancreatic cancer is responsible for nearly 40,000 deaths in the U.S. annually, with a dismal 5-year survival rate below 7%. The poor therapeutic outcomes reflect a paucity of new approaches targeting the genomic underpinnings ...

  1. Characterizing deformability and surface friction of cancer cells

    E-Print Network [OSTI]

    Byun, Sangwon

    Metastasis requires the penetration of cancer cells through tight spaces, which is mediated by the physical properties of the cells as well as their interactions with the confined environment. Various microfluidic approaches ...

  2. The use of polarized light for skin cancer detecton 

    E-Print Network [OSTI]

    DeLaughter, Aimee Hill

    2002-01-01

    detection system. Presented here is a method for the optical determination of cancerous tissue using polarized light. This thesis describes the development of a polarimetric imaging system including its calibration and testing. In addition, experiments...

  3. Investigating immune surveillance, tolerance, and therapy in cancer

    E-Print Network [OSTI]

    Cheung, Ann F

    2009-01-01

    Maximizing the potential of cancer immunotherapy requires model systems that closely recapitulate human disease to study T cell responses to tumor antigens and to test immune therapeutic strategies. Current model systems ...

  4. Novel mechanisms of endothelial-epithelial interactions underlying cancer metastasis

    E-Print Network [OSTI]

    Connor, Yamicia Doyasi

    2013-01-01

    Elucidation of molecular mechanisms underlying metastasis is the final frontier in cancer biology research. Identifying individual pathways in the metastatic cascade could lead to development of metastasis-specific ...

  5. Measuring the effects of drugs on single cancer cell growth

    E-Print Network [OSTI]

    Weng, Yaochung

    2012-01-01

    Understanding the effectiveness of a drug therapy on halting disease progression is an essential aspect of cancer biology. Conventional assays that study cell behavior after a drug intervention report the average response ...

  6. Breast cancer incidence following preeclampsia or gestational hypertension 

    E-Print Network [OSTI]

    Wormuth, Jennifer Karen

    1997-01-01

    A retrospective cohort study was conducted to examine the relationship between preeclampsia or gestational hypertension and subsequent breast cancer in a population of 6,564 pregnant women. Data on the study population came from the Child Health...

  7. Systems consequences of amplicon formation in human breast cancer

    E-Print Network [OSTI]

    Inaki, Koichiro

    Chromosomal structural variations play an important role in determining the transcriptional landscape of human breast cancers. To assess the nature of these structural variations, we analyzed eight breast tumor samples ...

  8. Tumour microenvironment interactions of small cell lung cancer

    E-Print Network [OSTI]

    Hodkinson, Philip Simon

    2009-01-01

    Small cell lung cancer (SCLC) is characterised by rapid growth, early metastatic spread and poor long-term survival. The tumour is initially sensitive to chemotherapy and thus objective response rates are high. Unfortunately, ...

  9. Selectins Mediate Small Cell Lung Cancer Systemic Metastasis

    E-Print Network [OSTI]

    Heidemann, Franziska

    Metastasis formation is the major reason for the extremely poor prognosis in small cell lung cancer (SCLC) patients. The molecular interaction partners regulating metastasis formation in SCLC are largely unidentified, ...

  10. Text Mining in Cancer Gene and Pathway Prioritization

    E-Print Network [OSTI]

    Riedlinger, Gregory

    Prioritization of cancer implicated genes has received growing attention as an effective way to reduce wet lab cost by computational analysis that ranks candidate genes according to the likelihood that experimental ...

  11. Genomics at the Ontario Institute for Cancer Research

    SciTech Connect (OSTI)

    Ali, Johar

    2010-06-02

    Johar Ali of the Ontario Institute for Cancer Research discusses genomics and next-gen applications at the OICR on June 2, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM

  12. Our Role in the War on Cancer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Our Role in the War on Cancer Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new window) Click to share on...

  13. Jackson Poulos Gene Expression Profiling in Cancer Diagnosis

    E-Print Network [OSTI]

    Brutlag, Doug

    is oncogenesis, or the formation and creation of cancerous tumor cells (Delaval). At its most basic level, oncogenesis involved a cell's internal mechanisms becoming altered in order to allow for uninhibited cell

  14. An Analytical Method For Multi-class Molecular Cancer Classification

    E-Print Network [OSTI]

    Poggio, Tomaso

    Institute / Massachusetts Institute of Technology Center for Genome Research, Cambridge, MA 02139 Vector Machines. We apply this methodology to the diagnosis of multiple common adult malignancies using using standard clinical and histopathologic approaches. Molecular approaches to cancer classification

  15. Targeting the tight junction : immunotherapy of colon cancer

    E-Print Network [OSTI]

    Ackerman, Margaret E

    2010-01-01

    A33 is a cell surface glycoprotein of colon epithelium with a long clinical history as a target in antibody-based cancer therapy. Despite being present in normal colon, radio-labeled antibodies against A33 are selectively ...

  16. Cell Death Pathways in Photodynamic Therapy of Cancer

    E-Print Network [OSTI]

    Mroz, Pawel

    Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be ...

  17. Overshoot during phenotypic switching of cancer cell populations

    E-Print Network [OSTI]

    Sellerio, Alessandro L; Ben-Moshe, Noa Bossel; Coco, Stefania; Piccinini, Andrea; Myers, Christopher R; Sethna, James P; Giampietro, Costanza; Zapperi, Stefano; La Porta, Caterina A M

    2015-01-01

    The dynamics of tumor cell populations is hotly debated: do populations derive hierarchically from a subpopulation of cancer stem cells (CSCs), or are stochastic transitions that mutate differentiated cancer cells to CSCs important? Here we argue that regulation must also be important. We sort human melanoma cells using three distinct cancer stem cell (CSC) markers - CXCR6, CD271 and ABCG2 - and observe that the fraction of non-CSC-marked cells first overshoots to a higher level and then returns to the level of unsorted cells. This clearly indicates that the CSC population is homeostatically regulated. Combining experimental measurements with theoretical modeling and numerical simulations, we show that the population dynamics of cancer cells is associated with a complex miRNA network regulating the Wnt and PI3K pathways. Hence phenotypic switching is not stochastic, but is tightly regulated by the balance between positive and negative cells in the population. Reducing the fraction of CSCs below a threshold tr...

  18. Designer Proteins Target Epstein-Barr-Virus-Associated Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Designer Proteins Target Epstein-Barr-Virus-Associated Cancer Print Immortality is not a good thing for cells, and in fact, cells will destroy themselves in a process called...

  19. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism...

  20. Nested methylation-specific polymerase chain reaction cancer detection method

    DOE Patents [OSTI]

    Belinsky, Steven A. (Albuquerque, NM); Palmisano, William A. (Edgewood, NM)

    2007-05-08

    A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or "nested" polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.