Sample records for fred hutchinson cancer

  1. Fred Hutchinson Cancer Research Center, Seattle, Washington: Laboratories for the 21st Century Case Studies (Revision)

    SciTech Connect (OSTI)

    Not Available

    2002-03-01T23:59:59.000Z

    This case study was prepared by participants in the Laboratories for the 21st Century program, a joint endeavor of the U.S. Environmental Protection Agency and the U.S. Department of Energy's Federal Energy Management Program. The goal of this program is to foster greater energy efficiency in new laboratory buildings for both the public and the private sectors. Retrofits of existing laboratories are also encouraged. The energy-efficient features of the laboratories in the Fred Hutchinson Cancer Research Center complex in Seattle, Washington, include extensive use of efficient lighting, variable-air-volume controls, variable-speed drives, motion sensors, and high-efficiency chillers and motors. With about 532,000 gross square feet, the complex is estimated to use 33% less electrical energy than most traditional research facilities consume because of its energy-efficient design and features.

  2. Fred Hutchinson Cancer Research Center, Seattle, Washington: Laboratories for the 21st Century Case Studies

    SciTech Connect (OSTI)

    Not Available

    2001-12-01T23:59:59.000Z

    This case study was prepared by participants in the Laboratories for the 21st Century program, a joint endeavor of the U.S. Environmental Protection Agency and the U.S. Department of Energy's Federal Energy Management Program. The goal of this program is to foster greater energy efficiency in new laboratory buildings for both the public and the private sectors. Retrofits of existing laboratories are also encouraged. The energy-efficient features of the laboratories in the Fred Hutchinson Cancer Research Center complex in Seattle, Washington, include extensive use of efficient lighting, variable-air-volume controls, variable-speed drives, motion sensors, and high-efficiency chillers and motors. With about 532,000 gross square feet, the complex is estimated to use 33% less electrical energy than most traditional research facilities consume because of its energy-efficient design and features.

  3. The University of Washington and the Fred Hutchinson Cancer Research Center Announce the

    E-Print Network [OSTI]

    Kaminsky, Werner

    and return the application via email with requested secondary materials to: Dr. Gabriele Varani, Department States, and for the identification and resolution of health care disparities. Thus, we are committed to biomedical research is particularly strong and the academic trajectory of the student is positive. PREP

  4. Exploring the Relationship between Neutral and Selective Mutations in Cancer

    E-Print Network [OSTI]

    Forrest, Stephanie

    Exploring the Relationship between Neutral and Selective Mutations in Cancer C. C. Maley 1;2 and S. Forrest 2;3 (cmaley@alum.mit.edu and forrest@cs.unm.edu) 1 Fred Hutchinson Cancer Research Center 1100 of normal cells into cancerous cells is an evolu- tionary process. Populations of precancerous cells

  5. Fred Loebl

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental Assessments (EA)Budget(DANCE) TargetFormsTrouble ShootingFred Loebl

  6. Hutchinson Utilities Commission- Commercial Energy Efficiency Program

    Broader source: Energy.gov [DOE]

    Hutchinson Utilities Commission (HUC) offers rebates to commercial customers in Hutchinson who perform energy conservation improvements to their businesses. These rebates are limited to one...

  7. Hutchinson Utilities Commission- Residential Energy Efficiency Program

    Broader source: Energy.gov [DOE]

    Hutchinson Utilities Commission (HUC) offers a rebate of up to $500 to residents of Hutchinson who perform energy conservation improvements to their home. Rebates are available for a variety of...

  8. Henry and Fred Learn about Lead

    E-Print Network [OSTI]

    Holsinger, Kent

    Henry and Fred Learn about Lead Joan Bothell Activity book #12;Henry and Fred Learn about Lead the children's storybook Henry and Fred Learn about Lead/Enrique y Federico aprenden sobre el plomo (2003 of this activity book. The Henry and Fred storybook is about keeping children safe from lead poisoning, a serious

  9. NATURE REVIEWS | GENETICS VOLUME 5 | JUNE 2004 | 405 HIGHLIGHT ADVISORS

    E-Print Network [OSTI]

    OF QUEENSLAND, AUSTRALIA LEONID KRUGLYAK FRED HUTCHINSON CANCER RESEARCH CENTER, USA STANLEY MALOY SAN DIEGO STATE UNIVERSITY, USA BARBARA MEYER UNIVERSITY OF CALIFORNIA, BERKELEY, USA JOHN QUAKENBUSH

  10. Hutchinson, Kansas Revitalized by Clean Energy Jobs | Department...

    Broader source: Energy.gov (indexed) [DOE]

    Addthis Employees speak about the changes happening in their lives since a wind turbine component manufacturing facility came to Hutchinson, Kansas. | Video courtesy of...

  11. Hutchinson, Kansas: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are8COaBulkTransmissionSitingProcess.pdfGetecGtel JumpCounty, Texas: Energy ResourcesMontana:17202°,Hutchinson,

  12. Fred Lipschultz | Department of Energy

    Office of Environmental Management (EM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33 1112011 Strategic2 OPAM Flash2011-12 OPAM Revised DOEDepartment ofFossilFred Lipschultz About Us

  13. 'ETALE WILD KERNELS OF EXCEPTIONAL NUMBER FIELDS KEVIN HUTCHINSON

    E-Print Network [OSTI]

    'ETALE WILD KERNELS OF EXCEPTIONAL NUMBER FIELDS KEVIN HUTCHINSON Abstract.We clarify the relationship between higher 'etale wild kernels * *of a number- cyclotomic tower of the field. We also determine the relationship betwee* *n the 'etale wild kernel

  14. The Case for Strategic Oscillation Fred Glover

    E-Print Network [OSTI]

    Hao, Jin-Kao

    for Strategic Oscillation Fred Glover OptTek Systems, Inc., 1919 Seventh Street, Boulder, CO 80302 USA glover implications for future research. Manuscript Click here to download Manuscript: ANOR Glover and Jin

  15. Introducing FRED, Enabling Unique Visualization and Manipulation...

    Open Energy Info (EERE)

    Sfederspiel's picture Submitted by Sfederspiel(5) Member 20 May, 2013 - 13:28 FRED Free Energy Data Map OpenEI Tool Visualization The U.S. Department of Energy, the Pacific...

  16. Construction heuristics for the asymmetric TSP Fred Glover

    E-Print Network [OSTI]

    Gutin, Gregory

    Construction heuristics for the asymmetric TSP Fred Glover School of Business, University of Colorado, Boulder CO 80309­0419, USA Fred.Glover@Colorado.EDU Gregory Gutin Department of Mathematical

  17. Distribution and Abstract Types in Emerald N. Hutchinson

    E-Print Network [OSTI]

    Black, Andrew P.

    Distribution and Abstract Types in Emerald A. Black N. Hutchinson E. Jul H. Levy L. CarterEEE TRANSACTIONS ON SOFTWARE ENGINEERING, VOL. SE-13. NO. 1, JANUARY 1987 65 Distribution and Abstract Types-Emerald is an object-based language for programming distributed subsystems and applications. Its novel features include

  18. ETALE WILD KERNELS OF EXCEPTIONAL NUMBER FIELDS KEVIN HUTCHINSON

    E-Print Network [OSTI]

    #19; ETALE WILD KERNELS OF EXCEPTIONAL NUMBER FIELDS KEVIN HUTCHINSON Abstract. We clarify the relationship between higher #19;etale wild kernels of a number #12;eld at the prime 2 and the Galois between the #19;etale wild kernel and the group of in#12;nitely divisible elements of H 2 (F; Z 2 (j + 1

  19. ETALE WILD KERNELS OF EXCEPTIONAL NUMBER FIELDS KEVIN HUTCHINSON

    E-Print Network [OSTI]

    ´ETALE WILD KERNELS OF EXCEPTIONAL NUMBER FIELDS KEVIN HUTCHINSON Abstract. We clarify the relationship between higher ´etale wild kernels of a number field at the prime 2 and the Galois between the ´etale wild kernel and the group of infinitely divisible elements of H2 (F, Z2(j + 1)){2}. 1

  20. Plasticity at the micron scale John W. Hutchinson*

    E-Print Network [OSTI]

    Hutchinson, John W.

    Plasticity at the micron scale John W. Hutchinson* Division of Engineering and Applied Sciences into the plastic range: smaller is stronger. This eect has important implications for an increasing number of applications in electronics, structural materials and MEMS. Plastic behavior at this scale cannot

  1. ORIGINAL ARTICLE Lipocalin 2 is required for BCR-ABL-induced tumorigenesis

    E-Print Network [OSTI]

    Strong, Roland K.

    Technology (ERAYO), Japan Science and Technology Corporation, Osaka, Japan and 7 Fred Hutchinson Cancer and marrow of mice, leading to early death in contrast to parental K562 or K562 clone (C6) expressing low

  2. The Emerald Programming Language1 Norman C. Hutchinson, Rajendra K. Raj,

    E-Print Network [OSTI]

    Black, Andrew P.

    The Emerald Programming Language1 REPORT Norman C. Hutchinson, Rajendra K. Raj, Andrew P. Black addresses: Norman Hutchinson, Department of Computer Science, University of Ari- zona, Tucson, AZ 85721. Andrew Black, Digital Equipment Corporation, 550 King Street, Littleton, MA 01460. Eric Jul, DIKU

  3. Fred Olsen Renewables Ltd | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual SiteofEvaluating A PotentialJumpGermanFife Energy ParkForkedFranklin ElectricFred Olsen

  4. astronaut fred haise: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    can be expanded by imaginative children and adults. Rules to stay lead simple rules to protect himself, Sue, and Fred from lead. Rule 1: Stay away from paint dust and paint...

  5. Fine-Grained Mobility in the Emerald System Eric :lul, Henry Levy, Norman Hutchinson, and Andrew Black*

    E-Print Network [OSTI]

    Black, Andrew P.

    Fine-Grained Mobility in the Emerald System Eric :lul, Henry Levy, Norman Hutchinson, and Andrew of Copenhagen, Universitetparken 1, DK- 2100 Copenhagen, Denmark. Norman Hutchinson, Depart- ment of Computer Science, University of Arizona, Tucson, AZ 85721. Andrew Black, Digital Equipment Corporation, 550 King

  6. Computer Science and Decision Theory Fred S. Roberts 1

    E-Print Network [OSTI]

    Computer Science and Decision Theory Fred S. Roberts 1 DIMACS Center, Rutgers University, Piscataway, NJ 08854 USA froberts@dimacs.rutgers.edu Abstract This paper reviews applications in computer in the social and decision sciences of newer decision-theoretic methods developed with computer science

  7. Data Clustering Using Evidence Accumulation Ana L.N. Fred

    E-Print Network [OSTI]

    Fred, Ana

    Data Clustering Using Evidence Accumulation Ana L.N. Fred Telecommunications Institute Instituto State University, USA jain@cse.msu.edu Abstract We explore the idea of evidence accumulation for com, ultimately imposing hyper-spherical clusters on the data. We explore the idea of evidence accumulation

  8. Experience Curves and Solar PV Fred Heutte, Senior Policy Associate

    E-Print Network [OSTI]

    Experience Curves and Solar PV Fred Heutte, Senior Policy Associate NW Energy Coalition September 3 resources costs as being ranges rather than fixed values. It is evident that the question of future solar PV small percentage of all resources at present, there is a strong sense that once solar PV reaches "grid

  9. Detecting Intrusion Faults in Remotely Controlled Systems Salvatore Candido and Seth Hutchinson

    E-Print Network [OSTI]

    Hutchinson, Seth

    the design process. With this in mind, researchers have begun to address security issues specific to controlDetecting Intrusion Faults in Remotely Controlled Systems Salvatore Candido and Seth Hutchinson to a remote-controlled system (deemed an "intrusion fault" or "intrusion") despite attempts to conceal

  10. A Data Synchronization Service for Ad Hoc Groups Terry Coatta, Norman C. Hutchinson, Andrew Warfield and Joseph H. T. Wong

    E-Print Network [OSTI]

    Warfield, Andrew

    A Data Synchronization Service for Ad Hoc Groups Terry Coatta, Norman C. Hutchinson, Andrew: norm@cs.ubc.ca Computer Laboratory, University of Cambridge, Cambridge, United Kingdom Email: andrew

  11. NEWS RELEASE Sept. 4, 2014 FRED JONES JR. MUSEUM OF ART

    E-Print Network [OSTI]

    Oklahoma, University of

    NEWS RELEASE Sept. 4, 2014 FRED JONES JR. MUSEUM OF ART UNIVERSITY OF OKLAHOMA - NORMAN RANDI GILL hour at the Fred Jones Jr. Museum of Art at the University of Oklahoma. The complimentary weekly concert series begins at noon Sept. 9 in the museum's Sandy Bell Gallery. A cooperative effort between

  12. NEWS RELEASE September 5, 2013 FRED JONES JR. MUSEUM OF ART

    E-Print Network [OSTI]

    Oklahoma, University of

    NEWS RELEASE September 5, 2013 FRED JONES JR. MUSEUM OF ART UNIVERSITY OF OKLAHOMA - NORMAN AMANDA at the Fred Jones Jr. Museum of Art at the University of Oklahoma. The complimentary weekly concert series begins at noon Sept. 10 in the museum's Sandy Bell Gallery. A cooperative effort between the OU School

  13. A review of "The Works of Lucy Hutchinson" edited by Reid Barbour and David Norbrook

    E-Print Network [OSTI]

    Caldwell, Tanya

    2013-01-01T23:59:59.000Z

    exercise in textual engagement. Reid Barbour and David Norbrook, eds. #31;e Works of Lucy Hutchinson. Volume I: Translation of Lucretius. #18; parts. Latin text ed. by Maria Cristina Zerbino. Oxford: Oxford University Press, #18;#17;#16;#18;. cxlvi + #31... of the books of her translation. #2;ese are each prefaced by an argument and juxtaposed with the Latin text that she used, prepared by Maria Cristina Zerbino. #2;e translation appears on the right hand page and the Latin on the left. #2;e texts...

  14. A review of "The Works of Lucy Hutchinson" edited by Reid Barbour and David Norbrook

    E-Print Network [OSTI]

    Caldwell, Tanya

    2013-01-01T23:59:59.000Z

    exercise in textual engagement. Reid Barbour and David Norbrook, eds. #31;e Works of Lucy Hutchinson. Volume I: Translation of Lucretius. #18; parts. Latin text ed. by Maria Cristina Zerbino. Oxford: Oxford University Press, #18;#17;#16;#18;. cxlvi + #31... of the books of her translation. #2;ese are each prefaced by an argument and juxtaposed with the Latin text that she used, prepared by Maria Cristina Zerbino. #2;e translation appears on the right hand page and the Latin on the left. #2;e texts...

  15. 666 JID 2005:191 (1 March) Gilbert et al. M A J O R A R T I C L E

    E-Print Network [OSTI]

    Gilbert, Peter

    for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington; 2 Vax vaccines containingrecombinant HIV-1 envelope glycoprotein 120 (rgp120) antigens. The first trial (VAX004 November 2004; electronically published 27 January 2005. Reprints or correspondence: Dr. Marc Gurwith, Vax

  16. By Fred Pearce Published: 1:00PM BST 16 Aug 2007

    E-Print Network [OSTI]

    Stevenson, Paul

    109.xml) A weekly column taking an inside look at the environment, by Fred Pearce Climate change irony Suddenly, everyone wants a share of the Arctic. And all because climate change is removing the ice that there are such large chunks of the planet left that have not been claimed. Where else? Russia began the "scramble

  17. A New Driving Assistant for Automobiles Fred Yu, Bozena Kaminska and Pawel Gburzynski

    E-Print Network [OSTI]

    Gburzynski, Pawel

    A New Driving Assistant for Automobiles Fred Yu, Bozena Kaminska and Pawel Gburzynski School in the United States alone, approximately six millions automobiles accidents take place [1]. A great portion of these automobile accidents is caused by the drivers' lack of concentration while operating their vehicles. Some

  18. A Wireless Sensor-Based Driving Assistant for Automobiles Fred Yu, Bozena Kaminska, and Pawel Gburzynski

    E-Print Network [OSTI]

    Gburzynski, Pawel

    A Wireless Sensor-Based Driving Assistant for Automobiles Fred Yu, Bozena Kaminska, and Pawel alone, approximately six million automobile accidents take place. In total, those accidents result 230 billion US dollars [1]. A large fraction of all automobile accidents is caused by the drivers

  19. About the role of the Higgs boson in the early Fred Jegerlehner, DESY Zeuthen/Humboldt University Berlin

    E-Print Network [OSTI]

    Rder, Beate

    About the role of the Higgs boson in the early universe Fred Jegerlehner, DESY Zeuthen April 16-17, 2014 5 #12;The Higgs is special! the Higgs boson was invented 1964 by Higgs, Englert

  20. Robin Hutchinson, Gamil Tadros, Jadwiga Kroman, Sami Rizkalla, "Use of Externally Bonded FRP Systems for Rehabilitation of Bridges in Western Canada," Page 1

    E-Print Network [OSTI]

    Systems for Rehabilitation of Bridges in Western Canada," Page 1 Use of Externally Bonded FRP Systems for Rehabilitation of Bridges in Western Canada Robin Hutchinson, Gamil Tadros, Jadwiga Kroman, Sami Rizkalla Synopsis: Since its inception in 1995, the ISIS Canada research network has developed design procedures

  1. TBU-0078 - In the Matter of Fred Hua | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn April 23, 2014,ZaleskiThis Decision considers an Appeal ofIn a letter dated JanuaryFred

  2. Fred Richard Mynatt, 1981 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron4(SC) MappingOctober 12,U.S. DOE OfficeU.S. DOEFred N. Mortensen,Fred

  3. Hi FRED Team! Welcome to our community area | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual SiteofEvaluatingGroup | Open EnergyInformation Hess Retail Natural Gas and Elec.HexHi FRED

  4. Library and Information Technology Final Report Fred Heath -Dean & Director, Sterling C. Evans Library, On-Campus Co-Chair

    E-Print Network [OSTI]

    Library and Information Technology Final Report Members Fred Heath - Dean & Director, Sterling C. Evans Library, On-Campus Co-Chair Ron Skaggs '65 - Chairman & CEO, HKS Architects, Off-Campus Co, Sterling C. Evans Library M. Michael Park - Attorney at Law Linda Parrish '78 - Professor, Department

  5. The Beginnings of Energy in Third Graders' Reasoning Jennifer Radoff 1, Fred Goldberg2, David Hammer3, and Sharon Fargason4

    E-Print Network [OSTI]

    Goldberg, Fred M.

    School, San Diego Abstract. We present snippets of third-graders discussing ideas about energy as partThe Beginnings of Energy in Third Graders' Reasoning Jennifer Radoff 1, Fred Goldberg2, David science education. INTRODUCTION Over the past 20 years, research on learning in physics and other sciences

  6. A Pervasive Computing Solution to Asset, Problem and Knowledge Management Suman K. Kalia, Charles C. Tappert, Allen Stix, and Fred Grossman

    E-Print Network [OSTI]

    Tappert, Charles

    . Tappert, Allen Stix, and Fred Grossman School of Computer Science and Information Systems Pace University desktop support team across the U.S. Introduction The following quote (IBM Pervasive Computing Website computing" is relatively new, its concept has historical precedence. Companies like IBM (IBM Redbook 1995

  7. aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Prostate cancer Prostate cancer Prostate cancer

    E-Print Network [OSTI]

    Paxton, Anthony T.

    --22000000 58 Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer Prostate cancer

  8. aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Lung cancer Lung cancer Lung cancer Lung c

    E-Print Network [OSTI]

    Paxton, Anthony T.

    --22000000 34 Lung cancer Lung cancer Lung cancer Lung c ancer Lung cancer Lung cancer Lung cancer L ung cancer Lung cancer Lung cancer Lung can cer Lung cancer Lung cancer Lung cancer Lun g cancer Lung cancer Lung cancer Lung cance r Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer Lung cancer

  9. LUNG CANCER 6. LUNG CANCER

    E-Print Network [OSTI]

    Paxton, Anthony T.

    LUNG CANCER 47 6. LUNG CANCER 6.1. SUMMARY Lung cancer was the third most common cancer in Ireland (Table 6.1). The average number of new lung cancer cases diagnosed each year was 1,000 in women and 1 for women and 1% for men. The risk of developing lung cancer up to the age of 74 was 1 in 37 for women and 1

  10. STOMACH CANCER 9. STOMACH CANCER

    E-Print Network [OSTI]

    Paxton, Anthony T.

    of association and strength of evidence Increases risk Decreases risk Convincing or probable Helicobacter pylori/obesity 9 1 Helicobacter and Cancer Collaborative Group, 2001; 2 International Agency for Research on Cancer

  11. CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM

    E-Print Network [OSTI]

    Illinois at Chicago, University of

    CANCER PROGRAM ANNUAL REPORT CANCER PROGRAM 2010 ANNUAL REPORT WITH STATISTICAL DATA FROM 2009 UNIVERSITY OF ILLINOIS MEDICAL CENTER #12;2 CANCER PROGRAM ANNUAL REPORT 2 #12;3 CANCER PROGRAM ANNUAL REPORT 3 UIMC CANCER PROGRAM CHANGING MULTIDISCIPLINARY CARE. FOR GOOD. #12;4 CANCER PROGRAM ANNUAL REPORT

  12. Cancer Imaging Clinical Cancer Research

    E-Print Network [OSTI]

    Near Ir; Heptamethine Cyanine Dyemediated; Xiaojian Yang; Chunmeng Shi; Rong Tong; Weiping Qian; Haiyen E. Zhau; Ruoxiang Wang; Guodong Zhu; Jianjun Cheng; Vincent W. Yang; Tianmin Cheng; Maged Henary; Lucjan Strekowski; W. K. Chung

    Purpose: Near-IR fluorescence imaging has great potential for noninvasive in vivo imaging of tumors. In this study, we show the preferential uptake and retention of two hepatamethine cyanine dyes, IR-783 and MHI-148, in tumor cells and tissues. Experimental Design: IR-783 and MHI-148 were investigated for their ability to accumulate in human cancer cells, tumor xenografts, and spontaneous mouse tumors in transgenic animals. Time- and concentration-dependent dye uptake and retention in normal and cancer cells and tissues were compared, and subcellular localization of the dyes and mechanisms of the dye uptake and retention in tumor cells were evaluated using organelle-specific tracking dyes and bromosulfophthalein, a competitive inhibitor of organic anion transporting peptides. These dyes were used to detect human cancer metastases in a mouse model and differentiate cancer cells from normal cells in blood. Results: These near-IR hepatamethine cyanine dyes were retained in cancer cells but not normal cells, in tumor xenografts, and in spontaneous tumors in transgenic mice. They can be used to detect cancer metastasis and cancer cells in blood with a high degree of sensitivity. The dyes were found to concentrate in the mitochondria and lysosomes of cancer cells, probably through organic anion transporting peptides,

  13. FRED | OpenEI Community

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  17. OpenEI Community - FRED

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  18. FRED | OpenEI Community

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  19. FRED | OpenEI Community

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  20. FRED | OpenEI Community

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  1. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualPropertyd8c-a9ae-f8521cbb8489 NoEurope BV Jump to:FASFMI-HD High-DefinitionVisualization Type

  2. FRED | OpenEI Community

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  3. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualPropertyd8c-a9ae-f8521cbb8489 NoEurope BV Jump to:FASFMI-HD High-DefinitionVisualizationTool

  4. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualPropertyd8c-a9ae-f8521cbb8489 NoEurope BV Jump to:FASFMI-HD

  5. FRED | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualPropertyd8c-a9ae-f8521cbb8489 NoEurope BV Jump to:FASFMI-HDFRED Type Term Title Author Replies

  6. Hidden Process Models Rebecca A. Hutchinson

    E-Print Network [OSTI]

    , and evaluates this framework in the context of fMRI. We provide the HPM formalism, inference and learning of how to visualize the learned mod- els. We conclude that the HPM extensions incorporating domain

  7. STARTLINK COMPOSITE HOUSING J. A. Hutchinson1

    E-Print Network [OSTI]

    Mottram, Toby

    lower embodied energy than a timber frame building, avoids site waste (20-25% of all UK waste friendly and up to 25% cheaper than traditional building. Keywords: Cost, Speed, Energy, Waste, Environment) and reduces shipping and assembly costs because of the light weight. Lightweight houses are easier to build

  8. Hutchinson Utilities Comm | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual SiteofEvaluatingGroup | OpenHunan Runhua New Energy Development CoHustisford Utilities

  9. Josephine Ford Cancer Center Cancer Research Programs

    E-Print Network [OSTI]

    Berdichevsky, Victor

    Josephine Ford Cancer Center Cancer Research Programs presented to WSU SOM PAD January 10, 2012 presented by Sandra A. Rempel, Ph.D. Associate Director of Research, JFCC #12;JFCC Cancer Research Programs Cancer Epidemiology, Prevention and Control Program Members: Gwen Alexander, Andrea Cassidy

  10. 1 888 939 3333 | cancer.ca Cancer Statistics

    E-Print Network [OSTI]

    Habib, Ayman

    1 888 939 3333 | cancer.ca Canadian Cancer Statistics 2013 Special topic: Liver cancer Produced by Canadian Cancer Society, Statistics Canada, Public Health Agency of Canada, Provincial/Territorial Cancer Registries cancer.ca/statistics #12;2Canadian Cancer Society n Canadian Cancer Statistics 2013 Citation

  11. CANCER BIOLOGY Infectioustumourcells

    E-Print Network [OSTI]

    Nowak, Martin A.

    CANCER BIOLOGY Infectioustumourcells David Dingli and Martin A. Nowak Cancer cells are generally infectious agents and be transmitted between individuals. The current view of cancer development is that normal cells are transformed into tumour cells by sequential mutations that activate cancer- promoting

  12. The National Cancer Institute,

    E-Print Network [OSTI]

    The National Cancer Institute, International Cancer Information Center Bldg. 82, Rm 123 Bethesda, MD 20892 The National Cancer Institute (NCI) is part of the Federal Government. NCI coordinates the government's cancer research program. It is the largest of the 17 biomedical research institutes and centers

  13. CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER

    E-Print Network [OSTI]

    Sherman, S. Murray

    CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRA NSFO RMING LIVES THRO UG H RE SE ARC H #12;CancerProgressReport.org // AACR.org // #CancerProgress14 AACR CANCER PROGRESS REPORT 2014 TRANSFORMING LIVES THROUGH RESEARCH #12;II AACR Cancer Progress Report 2014

  14. Paul Workman Cancer Research UK Cancer Therapeutics Unit

    E-Print Network [OSTI]

    Paul Workman Cancer Research UK Cancer Therapeutics Unit Institute of Cancer Research/Royal Marsden Hospital Sutton, Surrey SM2 5NG UK ian.collins@icr.ac.uk Drugging the cancer genome: The challenges therapeutic agents Personalised diagnosis and treatment Exploiting cancer biology and the cancer genome

  15. aallll IIrreell aanndd ccaanncceerr ssttaattiissttiiccss sseeccoonndd rreeppoorrtt 11999988--22000000 Colorectal cancer Colorectal cancer Colorectal

    E-Print Network [OSTI]

    Paxton, Anthony T.

    explain the higher US survival rate. Aggressive treatment may also be a factor. 5. Colorectal cancer Risks--22000000 28 Colorectal cancer Colorectal cancer Colorectal cancer Colorectal cancer Colorectal cancer Col orectal cancer Colorectal cancer Colorectal ca ncer Colorectal cancer Colorectal cancer Color ectal cancer

  16. Cancer Research Beckman Institute

    E-Print Network [OSTI]

    Illinois at Urbana-Champaign, University of

    Cancer Research Beckman Institute FOR ADVANCED SCIENCE AND TECHNOLOGY #12;T The medical and scientific worlds have known for many years that in order to truly understand and treat cancer, the fight has and cancerous tumors have to first be visualized at the smallest scales possible, and then treated in the most

  17. Analysis of Assembly Bill 1000: Cancer Treatment

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2011-01-01T23:59:59.000Z

    of recurrent cancers, and treatment of cancers that cannotNeill VJ, Twelves CJ. Oral cancer treatment: Developments inchanging paradigm in cancer treatment: Oral chemotherapy.

  18. Analysis of Senate Bill 961: Cancer Treatment

    E-Print Network [OSTI]

    California Health Benefits Review Program (CHBRP)

    2010-01-01T23:59:59.000Z

    of recurrent cancers, and treatment of cancers that cannotNeill VJ, Twelves CJ. Oral cancer treatment: Developments inchanging paradigm in cancer treatment: Oral chemotherapy.

  19. Lymphatic and Angiogenic Candidate Genes Predict the Development of Secondary Lymphedema following Breast Cancer Surgery

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    following breast cancer treatment. Cancer Epidemiollymphedema after breast cancer treatment. Cancer Epidemiolfollowing breast cancer treatment. Clin Cancer Res 18: 232

  20. Eur J Cancer. Author manuscript Social inequalities in cancer incidence and cancer survival: Lessons from

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Eur J Cancer. Author manuscript Page /1 5 Social inequalities in cancer incidence and cancer ( ). With regards to cancer risk, a first comprehensive review of socioeconomic inequalities was1 published by IARC in 1997 ( ). This review covered inequalities in cancer mortality, incidence and survival and discussed

  1. Cancer Due to Prolonged Inflammation

    E-Print Network [OSTI]

    Lingampalli, Nithya

    2013-01-01T23:59:59.000Z

    Werb J. Inflammation and cancer. Nature. 2002 December 19;J.T. , Szabo E. , et al. Cancer and inflammation: PromiseInflammation, a Key Event in Cancer Development. Molecular

  2. Bismuth 213 Cancer Treatment

    ScienceCinema (OSTI)

    None

    2013-05-28T23:59:59.000Z

    See how INL scientists are increasing supplies of radioactive medical isotopes to treat cancer. For more information about INL research, visit http://www.facebook.com/idahonationallaboratory.

  3. Skin metastases from lung cancer

    E-Print Network [OSTI]

    Mollet, Todd W; Garcia, Carlos A; Koester, Glenn

    2009-01-01T23:59:59.000Z

    cutaneous metastases from the lung frequently indicate aof skin metastases from lung cancer. Intern Med. 1996; 35:9. Coslett LM, Katlic MR. Lung cancer with skin metastasis.

  4. May 20, 2010 Dr. Fred Hartmeister, Dean

    E-Print Network [OSTI]

    Rock, Chris

    in Geosciences. What follows is the Geosciences response to the report and the outcome of the assessment meeting. However, our loads are determined by student demand, and our increased enrollments provide less Plan, with specific focus on strategic hiring, graduate student recruitment and retention. 7. Continue

  5. 18 October 2002 From: Fred Heutte

    E-Print Network [OSTI]

    features, among many, that deserve attention. The first is that it places energy production and use fully of the Act's requirement to integrate electric energy production and our environment. Regional Scope for New

  6. PMOS Revisited Fred Brown and Dave Munro

    E-Print Network [OSTI]

    Munro, David S.

    Object Space, PMOS, garbage collection algorithm is designed to incrementally collect all garbage of garbage into small enough units so that disruption to the running system is insignificant. PMOS is able to collect the small units in arbitrary orders whilst eliminating cyclic garbage and being able to guarantee

  7. Curriculum Vita for Fred W. Huffer

    E-Print Network [OSTI]

    of the Scan Statis- tic Using Moments of the Number of Clumps, Journal of the American Statistical Association, Department of Statistics, Florida State University 8/888/02 Associate Professor, Department of Statistics Statistical Association 86, 114-129 (1991). Wu, H., and Huffer, F. W. Modeling the Distribution of Plant

  8. From Quarks to Real Life Fred Jegerlehner

    E-Print Network [OSTI]

    Rder, Beate

    ) Atom 10-8 10-4 e.m., QED Nucleus, Electron 10-12 10-3 nuclear power Hadrons: Proton, Neutron 10 photon with charged particles, electrons,.... e+ e- Abelian theory U(1) phase transformations F only, color singlets, color unobservable! Confinement QUARKS are permanently confined inside HADRONS

  9. Fred L. Brown | Department of Energy

    Broader source: Energy.gov (indexed) [DOE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742 33Frequently20,000 RussianBy: Thomas P. D'Agostino, Undersecretary forCITIFormatSLACWith the

  10. fred andreas | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnualProperty Edit withTianlinPapersWindey Wind Home Rmckeel's Home Kyoung'sandreas Home Dc's

  11. FRED Overview Slides | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual SiteofEvaluating A PotentialJumpGerman AerospaceEfficiency Incentives and Policies |FPEFRFRED

  12. FRee Energy Data (FRED) | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand JumpConceptual Model,DOEHazelPennsylvania: EnergyExolis Energy JumpFAC 04-08-DOE GTP)

  13. OpenEI Community - fred andreas

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to: navigation, searchOfRoseConcernsCompany Oil and GasOff<div/0 en The Energy

  14. Fred C. Hartman | ornl.gov

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC) Environmental Assessments (EA)Budget(DANCE) TargetFormsTrouble Shooting

  15. Inflammation & Inflammation & cancer

    E-Print Network [OSTI]

    Beimel, Amos

    Tam & tnf dc cytokines metastasis metabolism #12;22 chemokine gradient in cancer (Balkwill et al. 2004 1861) Wound healing dc Tam & tnf cytokines metastasis therapeutics metabolism inflammation The end #12 & tnf cytokines metastasis metabolism #12;4 Motivation Cancer as an overhealing wound Lets Go! Wound

  16. Lung cancer...115 Chapter 11

    E-Print Network [OSTI]

    Paxton, Anthony T.

    NICR/NCRI Lung cancer...115 Chapter 11: Lung cancer (including trachea, bronchus and lung; C33-C34 of lung cancer diagnosed each year in Ireland during 2000-2004. o Male incidence rates decreased by 1 by 2.7%. o Higher levels of treatment occurred among those with small cell lung cancer (compared to non

  17. QUESTIONS & ANSWERS ABOUT LUNG CANCER

    E-Print Network [OSTI]

    QUESTIONS & ANSWERS ABOUT LUNG CANCER Q: What are the early signs of lung cancer? How would I know I have it? A: Some of the early warning signs of lung cancer are: · A cough that doesn't go away what may be causing these symptoms. Q: How is lung cancer diagnosed? A: Your doctor may do one or more

  18. Cancer Therapies: A Bane and a Boon

    E-Print Network [OSTI]

    Neogi, Sushrita

    2012-01-01T23:59:59.000Z

    Alternative Medicine in Cancer Treatment. (2012). Retrievedcancertopics/pdq/cam/cam-cancer-treatment/patient/page2 8.and alternative (CAM) cancer treatments in use, including

  19. Evidence That New Hypnotics Cause Cancer

    E-Print Network [OSTI]

    Kripke, Daniel F.

    2008-01-01T23:59:59.000Z

    medication use and risk of epithelial ovarian cancer.Cancer Epidemiol. Biomarkers Prev. , Hays, J. C. , Blazer,the likelihood of cancer causation is sufficiently strong

  20. Aneuploidy: Cancer's Fatal Flaw?

    E-Print Network [OSTI]

    Williams, Bret R.

    Aneuploidy is a characteristic of cancer, with greater than 90% of all solid tumors in humans carrying an aberrant karyotype. Yet, whether or how this condition contributes to tumorigenesis is not understood. Here we ...

  1. Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program Genetic Epidemiology of Cancer

    E-Print Network [OSTI]

    Weber, David J.

    Department of Epidemiology and Public Health, Division of Cancer Epidemiology Greenebaum Cancer Center Population Research Program ­ Genetic Epidemiology of Cancer Associate Professor Tenuretrack Health is expanding research in Cancer Genetic Epidemiology to enrich an already robust campuswide

  2. Hutchinson Community College Transfer Program to University of Kansas

    E-Print Network [OSTI]

    (Aerospace Systems, Chemical Systems, Digital Electronic Systems, Electromechanical Control Systems) Number 106 Intro To World Religions 3 HA 261 Intro to Modern Art 3 AR 102 History of Modern Art 3 PHIL 140

  3. Dallam Sherman Hansford Ochiltree Lipscomb Hartley Hutchinson Roberts Hemphill

    E-Print Network [OSTI]

    Baylor Wilbarger Wichita Archer Kent Stonewall Haskell Throckmorton Young Stephens Clay Jack Montague Tom Green Concho Schleicher Val Verde Menard McCulloch Mason Llano San Saba Mills Lampasas Burnet West

  4. Hutchinson County, South Dakota: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are8COaBulkTransmissionSitingProcess.pdfGetecGtel JumpCounty, Texas: Energy ResourcesMontana:17202°, -97.6982272°

  5. Hutchinson County, Texas: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are8COaBulkTransmissionSitingProcess.pdfGetecGtel JumpCounty, Texas: Energy ResourcesMontana:17202°,

  6. South Hutchinson, Kansas: Energy Resources | Open Energy Information

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov YouKizildere IRaghuraji Agro Industries Pvt LtdShawangunk, NewSingaporeSonix JapanCalifornia: EnergyHuntington, New

  7. Colorectal cancer and diet in Scotland

    E-Print Network [OSTI]

    Theodoratou, Evropi

    2008-01-01T23:59:59.000Z

    Introduction Colorectal cancer is a cancer that forms in the tissues of the colon and/ or rectum and more than 95% of colorectal cancers are adenocarcinomas. It is the third most common cancer in incidence and mortality ...

  8. Identifying Risk Groups Associated with Colorectal Cancer

    E-Print Network [OSTI]

    Jin, Huidong "Warren"

    , abbreviated as CRC) is the second leading cause of cancer-related deaths in the United States for both men to lung cancer in cause of cancer deaths. Despite the fact that it is highly preventable, approximately, colorectal cancer is the third most common cause of death from cancer in women (after breast and lung cancer

  9. Cell Senescence: Aging and Cancer

    ScienceCinema (OSTI)

    Campisi, Judith

    2013-05-29T23:59:59.000Z

    Scientists have identified a molecular cause behind the ravages of old age and in doing so have also shown how a natural process for fighting cancer in younger persons can actually promote cancer in older individuals.

  10. Hindawi Publishing Corporation Prostate Cancer

    E-Print Network [OSTI]

    Ahn, Hongshik

    Hindawi Publishing Corporation Prostate Cancer Volume 2011, Article ID 176164, 7 pages doi:10.1155/2011/176164 Clinical Study Effect of Zoledronic Acid on Bone Mineral Density in Men with Prostate Cancer Receiving cancer is well recognized. We assessed the effects of quarterly infusion of zoledronic acid on bone

  11. Early Lung Cancer Detection Program

    Broader source: Energy.gov [DOE]

    Since 2000, DOE has made screening for occupational lung cancer with low-dose helical computed tomography (CT) scans available to workers at high risk for lung cancer. Because former workers undertook essential activities to fulfill the Department's mission, many of them were at risk for lung cancer.

  12. Pomegranate Juice and Pomegranate Derived Natural Products as Alternative Treatment for Cancer Progression and Metastasis

    E-Print Network [OSTI]

    Wang, Lei

    2013-01-01T23:59:59.000Z

    prostate cancer. Cancer Treatment Reviews 36, Sternlicht,prostate cancer. Cancer Treatment Reviews 36, Steiner, H. ,prostate cancer. Cancer Treatment Reviews 36, Sureban,

  13. Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    Hunter DJ, Willett WC (1996): Nutrition and breast cancer.Cancer Causes Control 7:56- 37. Weiderpass E, Braaten T,of premenopausal breast cancer. Cancer Epidemiol.Biomarkers

  14. Prognosis of Breast Cancer using Genetic Programming

    E-Print Network [OSTI]

    Ludwig, Simone

    diseases. They grow at different rates and respond to different treatments. That is why people with cancer need treatment that is aimed at their kind of cancer. Therefore, it is important to identify the type of cancer accurately, so that the correct treatment can be started. Breast cancer is a cancer that starts

  15. Estimating radiogenic cancer risks

    SciTech Connect (OSTI)

    NONE

    1994-06-01T23:59:59.000Z

    This document presents a revised methodology for EPA`s estimation of cancer risks due to low-LET radiation exposures in light of information that has become available since the publication of BIER III, especially new information on the Japanese atomic bomb survivors. For most cancer sites, the risk model is one in which the age-specific relative risk coefficients are obtained by taking the geometric mean of coefficients derived from the atomic bomb survivor data employing two different methods for transporting risks from Japan to the U.S. (multiplicative and NIH projection methods). Using 1980 U.S. vital statistics, the risk models are applied to estimate organ-specific risks, per unit dose, for a stationary population.

  16. Modeling Prostate Cancer Detection Probability, with Applications

    E-Print Network [OSTI]

    Serfling, Robert

    investigating causes and treatments. Robert Serfling Modeling Prostate Cancer Detection Probability cancer present as well as tumor nodule sizes, to judge clinical significance before treatment selectionModeling Prostate Cancer Detection Probability, with Applications Robert Serfling1 University

  17. Erysipelas after breast cancer treatment (26 cases)

    E-Print Network [OSTI]

    2005-01-01T23:59:59.000Z

    Erysipelas after breast cancer treatment. Tunis Med, 2002 ,after breast cancer treatment (26 cases) A Masmoudi 1 , Iof 5.23 years after cancer treatment (3 months to 15 years)

  18. Could You Cure Cancer? Alastair M Thompson

    E-Print Network [OSTI]

    Greenaway, Alan

    Could You Cure Cancer? Alastair M Thompson Professor of Surgical Oncology, University of Dundee a.m.thompson ............................could YOU cure cancer? Some questions on cancer: #12;a.m.thompson @ dundee.ac.uk #12;

  19. Cancer Therapies: A Bane and a Boon

    E-Print Network [OSTI]

    Neogi, Sushrita

    2012-01-01T23:59:59.000Z

    on the surgical decision-making process for breast cancer.Cancer, 112(3), 489-494. 2. Grealy, Lucy (1994).Mifflin. 3. He, Lin (2011). Cancer Therapy. [PowerPoint

  20. Diet, MicroRNAs and Prostate Cancer

    E-Print Network [OSTI]

    Saini, Sharanjot; Majid, Shahana; Dahiya, Rajvir

    2010-01-01T23:59:59.000Z

    deregulation in human cancer. Cell Cycle. 2008;7:26436. 25.genomic regions involved in cancers. Proc Natl Acad Sci USA.A, Jacks T. MicroRNAs and cancer: short RNAs go a long way.

  1. Childhood Cancer Tracking Initiative in Massachusetts

    E-Print Network [OSTI]

    Childhood Cancer Tracking Initiative in Massachusetts: Developing a New Electronic Tool Presented (CEH) Massachusetts Department of Public Health (MDPH) #12;Childhood Cancer Tracking Initiative "Develop methods for linking environmental databases with childhood cancer incidence data to identify

  2. Mathematical Toolkit Unlocks Some Cancer Secrets

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Mathematical Models Shed New Light on Cancer Mutations Mathematical Models Shed New Light on Cancer Mutations Calculations Run at NERSC Pinpoint Rare Mutants More Quickly November...

  3. Breakthrough: Fighting Cancer with Nanoparticles

    ScienceCinema (OSTI)

    Rozhkova, Elena

    2013-04-19T23:59:59.000Z

    Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

  4. Breakthrough: Fighting Cancer with Nanoparticles

    SciTech Connect (OSTI)

    Rozhkova, Elena

    2012-01-01T23:59:59.000Z

    Argonne nanoscientist Elena Rozhkova is studying ways to enlist nanoparticles to treat brain cancer. This nano-bio technology may eventually provide an alternative form of therapy that targets only cancer cells and does not affect normal living tissue. Read more at http://1.usa.gov/JAXh7Q.

  5. Cancer Mortality and Wood Dust Exposure Among Participants in the American Cancer

    E-Print Network [OSTI]

    Salzman, Daniel

    Cancer Mortality and Wood Dust Exposure Among Participants in the American Cancer Society Cancer and Paolo Boffetta, MD, MPH3 In 1994, the International Agency for Research on Cancer (IARC) classified wood dust as a human carcinogen, based on very strong evidence of a carcinogenic risk of sino-nasal cancer

  6. Cancer Immunol Immunother . Author manuscript Anti-HER2 vaccines: new prospects for breast cancer therapy

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Cancer Immunol Immunother . Author manuscript Page /1 18 Anti-HER2 vaccines: new prospects for breast cancer therapy Maha Zohra Ladjemi 1 , William Jacot 2 , Thierry Chard sè 1 , Andr P legriné è 1 cancer accounts for more than 400.000 new cancer cases and more than 130.000 cancer deaths in Europe

  7. Skin cancer is the most com-mon form of cancer in the United

    E-Print Network [OSTI]

    Skin cancer is the most com- mon form of cancer in the United States. Excessive and unprotected exposure to the sun's ultraviolet radiation (UV light) is the primary risk factor for skin cancer. Howev- er, skin cancer is one of the most preventable types of cancer! The damaging and cumulative effects

  8. NON-MELANOMA SKIN CANCER 3. NON-MELANOMA SKIN CANCER

    E-Print Network [OSTI]

    Paxton, Anthony T.

    NON-MELANOMA SKIN CANCER 21 3. NON-MELANOMA SKIN CANCER 3.1. SUMMARY Non-melanoma skin cancer (NMSC their cancer diagnosis. Table 3.1 Summary information for non-melanoma skin cancer in Ireland, 1995 number of cases for both sexes presented in the 7079 age group. Figure 3.1 Age distribution of non-melanoma

  9. Extinction Models for Cancer Stem Cell Therapy

    E-Print Network [OSTI]

    Sehl, Mary; Zhou, Hua; Sinsheimer, Janet; Lange, Kenneth

    2009-01-01T23:59:59.000Z

    Characterization of acute lymphoblastic leukemia progenitor58], breast cancer [2], acute lymphoblastic leukemia [10],

  10. Extinction Models for Cancer Stem Cell Therapy

    E-Print Network [OSTI]

    Mary Sehl; Hua Zhou; Janet S. Sinsheimer; Kenneth L. Lange

    2011-01-01T23:59:59.000Z

    Characterization of acute lymphoblastic leukemia progenitor58], breast cancer [2], acute lymphoblastic leukemia [10],

  11. BREAST CANCER GROUP WOMEN'S HEALTH INTERDISCIPLINARY

    E-Print Network [OSTI]

    Spence, Harlan Ernest

    BREAST CANCER GROUP May 2009 WOMEN'S HEALTH INTERDISCIPLINARY RESEARCH CENTER [WHIRC] #12;2 Table: Breast Cancer Research and Treatment 4 Basic/Translational Research Carcinogenesis and Signaling Group 5R) Signaling in Breast Cancer 6 NF-B Family of Transcription Factors in Breast Cancer 7 Transgenic Mouse

  12. Contact Details Journeying Beyond Breast Cancer

    E-Print Network [OSTI]

    Espinosa, Horacio D.

    Home About Contact Details Facebook Search Journeying Beyond Breast Cancer making sense of the cancer experience Feeds: Posts Comments Cancer-fighting fountain pen May 20, 2009 by JBBC A research team be used both as a research tool in the development of next-generation cancer treatments

  13. Also in This Issue 2 International Cancer

    E-Print Network [OSTI]

    Müller, Jens-Dominik

    Also in This Issue 2 International Cancer Benchmarking Partnership 3 Improving Staging Information 4 Studying the Care of Older Prostate Cancer Patients (CARDI) 4 The Northern Ireland PSA Database 5 Lung Cancer Resection Rates 5 All Ireland Cancer Atlas 5 CaPPS Update 6 Living With and Beyond Prostate

  14. Making a difference... A National Cancer

    E-Print Network [OSTI]

    Birmingham, University of

    Making a difference... A National Cancer Research Institute (NCRI) Accredited Trials Unit Contacts Cancer Research UK Clinical Trials Unit School of Cancer Sciences University of Birmingham Edgbaston. Funding The CRCTU receives core funding from Cancer Research UK and has successfully obtained project

  15. CANCER RISKS AM I AT RISK?

    E-Print Network [OSTI]

    Hardy, Christopher R.

    CANCER RISKS AM I AT RISK? It is often hard to explain why one person develops cancer and another does not. There are risk factors that could increase a person's likelihood of developing cancer, however, some people may have many of these risk factors and never get cancer. When thinking about your

  16. What Lung Cancer Patients Need to Know

    E-Print Network [OSTI]

    Kaski, Samuel

    What Lung Cancer Patients Need to Know About Bone Health A Publication of The Bone and Cancer Foundation #12;Contents THIS PUBLICATION PROVIDES IMPORTANT INFORMATION ABOUT THE RELATIONSHIP BETWEEN LUNG CANCER AND BONE HEALTH. HOW BONE WORKS (PAGE 2). WHAT LUNG CANCER CAN DO TO BONE (PAGE 2). TREATING BONE

  17. The Cancer Genome Atlas Pan-Cancer analysis project

    E-Print Network [OSTI]

    Lander, Eric S.

    The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a ...

  18. Diabetes and breast cancer : the women's healthy eating & living study

    E-Print Network [OSTI]

    Erickson, Kirsten Diann

    2011-01-01T23:59:59.000Z

    weight after breast cancer treatments: evidence from thestatus), breast cancer treatment history (years sinceto follow less aggressive cancer treatments 33-37 associated

  19. Carbohydrate Intake and Outcomes among Postmenopausal Breast Cancer Survivors /

    E-Print Network [OSTI]

    Emond, Jennifer Ann

    2013-01-01T23:59:59.000Z

    of the primary breast cancer and treatments received overallof the primary cancer and treatments received, only twoduring and after cancer treatment: a guide for informed

  20. Feeding Frenzy: Shark Cartilage as Treatment for Cancer

    E-Print Network [OSTI]

    Saben, Jamie

    1997-01-01T23:59:59.000Z

    Over Shark Cartilage as Cancer Treatment." Journal of thewith shark cartilage as cancer treatment and are especiallyshark cartilage as a cancer treatment, assess the public's

  1. Diffusion MRI Methods for Improved Treatment Monitoring in Breast Cancer

    E-Print Network [OSTI]

    Aliu, Sheye

    2009-01-01T23:59:59.000Z

    2.9 Breast Cancer Treatment . . . . . . . 2.9.1. Localassessing antivascular cancer treatments. Br J Radiol, 2003.imaging, for breast cancer treatment monitoring. To achieve

  2. School Response to Families with Children with Cancer

    E-Print Network [OSTI]

    Nielsen, Shelley Lynn

    2010-01-01T23:59:59.000Z

    Coping with childhood cancer: Where do we go from here?issues in childhood cancer. School Psychology Review, 28(2),2001). Children surviving cancer: Psychosocial adjustment,

  3. Stromal Modulation of Radiation Carcinogenesis in Breast Cancer

    E-Print Network [OSTI]

    Nguyen, David Hiendat Hua

    2011-01-01T23:59:59.000Z

    receptor-negative breast cancer patients. J Clin Invest 120,Triple-Negative Breast Cancer: Distinguishing between Basaland Nonbasal Subtypes. Clin Cancer Res 15, 2302-2310. Reis-

  4. Canadian Expert Panel on Tobacco Smoke and Breast Cancer Risk

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    cigarette smoking, and the risk of breast cancer. Cancerand breast cancer risk. JAMA Ambrosone, C.B. , Kropp, S. ,genotypes, and breast cancer risk: pooled analysis and meta-

  5. Cancer prevention for global health: a report from the ASPO International Cancer Prevention Interest Group.

    E-Print Network [OSTI]

    Braithwaite, Dejana; Boffetta, Paolo; Rebbeck, Timothy R; Meyskens, Frank

    2012-01-01T23:59:59.000Z

    Bull 14. WHO. International Agency for Research on Cancer:World Cancer Report. In Stuart BW, Kleihues P, editors.of environmental and occupational cancer. Oncogene 2004;23:

  6. Cancer survivorship research: the challenge of recruiting adult long term cancer survivors from a cooperative clinical trials group

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    late effects of cancer treatments. Retrospective recruitmenteffects associated with cancer treatments. Implications foron the late effects of cancer treatment, due to the growing

  7. The effect of gender on Helicobacter pylori and gastric cancer

    E-Print Network [OSTI]

    Sheh, Alexander

    2011-01-01T23:59:59.000Z

    Gastric cancer is the 2nd leading cause of cancer death worldwide and the 4th most commonly diagnosed cancer worldwide. Helicobacter pylori infection is the major risk factor of gastric cancer, and as such, this bacterium ...

  8. Serum 25-hydroxyvitamin D and risk of breast cancer

    E-Print Network [OSTI]

    Mohr, Sharif Burgette

    2012-01-01T23:59:59.000Z

    and prevention of breast cancer: pooled analysis. AnticancerBray F, Ferlay J, Pisani P. Global cancer statistics, 2002.CA-Cancer J Clin. 2005;55(2):74-108. American Cancer

  9. Clinical Cancer Care Full screening services and diagnostics

    E-Print Network [OSTI]

    Myers, Lawrence C.

    Clinical Cancer Care · Full screening services and diagnostics · Advanced treatments for all forms of cancer · Most frequent cancers at the Cancer Center: Breast 15% Gastrointestinal 13% Skin 17% Lung 13 treatment protocols that link the latest Cancer Center research to clinical care · Familial Cancer Program

  10. Cancer Epidemiol Biomarkers Prev. Author manuscript Diet, cancer, and the lipidome

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Cancer Epidemiol Biomarkers Prev. Author manuscript Page /1 8 Diet, cancer, and the lipidome Bougnoux Philippe 1 * , Giraudeau Bruno 2 , Couet Charles 1 Nutrition, Croissance et Cancer1 INSERM : E211 with the development of breast cancer by delaying its occurrence makes identification of defined molecules a mandatory

  11. Seminars in Cancer Biology 15 (2005) 484493 Dynamics of colorectal cancer

    E-Print Network [OSTI]

    Nowak, Martin A.

    Seminars in Cancer Biology 15 (2005) 484­493 Review Dynamics of colorectal cancer Franziska Michora Abstract Colorectal cancer results from an accumulation of mutations in tumor suppressor genes and oncogenes. An additional defining characteristic of colorectal cancer is its genetic instability. Two main

  12. NATIONAL CANCER INSTITUTE The National Cancer Institute is accepting applications for its Fall 2011 HCIP class.

    E-Print Network [OSTI]

    Cinabro, David

    NATIONAL CANCER INSTITUTE The National Cancer Institute is accepting applications for its Fall 2011 by March 1st. Apply online! See website for further details. http://hcip.nci.nih.gov The National Cancer (NIH), is the Federal Government's principal agency for cancer research and training. The NCI

  13. Mabs against Pancreatic cancer Therapeutic antibodies for the treatment of pancreatic cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Mabs against Pancreatic cancer 1 Therapeutic antibodies for the treatment of pancreatic cancer pancreatic cancer inserm-00497886,version1-6Jul2010 Author manuscript, published in "TheScientificWorldJournal (electronic resource) 2010;10:1107-20" DOI : 10.1100/tsw.2010.103 #12;Mabs against Pancreatic cancer 2

  14. Do cancer cells undergo phenotypic switching? The case for imperfect cancer

    E-Print Network [OSTI]

    De Cindio, Fiorella

    Do cancer cells undergo phenotypic switching? The case for imperfect cancer stem cell markers Celoria 26, 20133 Milano, Italy. The identification of cancer stem cells in vivo and in vitro relies on specific surface markers that should allow to sort cancer cells in phenotypically distinct subpopulations

  15. Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer

    E-Print Network [OSTI]

    Greenaway, Alan

    Clinical Imaging and Intervention in Cancer: Imaging and Cryotherapy in Renal Cancer Graeme Houston Fluoroscopy 2 #12;Treatments for Cancer Palliative ­ Relief of obstruction ­ Reduce Bleeding ­ Pain Control ­ Avoid complications Disease Modifying 4 #12;Disease Modifying Cancer Treatment In Situ Ablation

  16. Targeting cancer metabolism: a therapeutic window opens

    E-Print Network [OSTI]

    Vander Heiden, Matthew G.

    Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...

  17. Hypoxia activated cell signaling receptors in cancer

    E-Print Network [OSTI]

    Lester, Robin D.

    2008-01-01T23:59:59.000Z

    cancer cells MCF-7 and MDA- MB-231. Biomed. Pharmacother.and prevents apoptosis in MDA-MB-231 breast cancer cells. J.Gaithersburg, MD). Cell Culture MDA-MB-468, MDA-MB-435, ZR-

  18. Lgr4 in Breast Cancer Stem Cells

    E-Print Network [OSTI]

    Zeng, Li

    2014-12-11T23:59:59.000Z

    Breast cancer is the most commonly diagnosed cancer among American women. G-protein coupled receptors (GPCR) comprise a huge family protein with almost 800 members. GPCRs sense molecules or other stimuli outside the cell, and activate intracellular...

  19. Genetics and molecular biology of breast cancer

    SciTech Connect (OSTI)

    King, M.C. [California Univ., Berkeley, CA (United States); Lippman, M. [Georgetown Univ. Medical Center, Washington, DC (United States)] [comps.

    1992-12-31T23:59:59.000Z

    This volume contains the abstracts of oral presentations and poster sessions presented at the Cold Springs Harbor Meeting on Cancer Cells, this meeting entitled Genetics and Molecular Biology of Breast Cancer.

  20. Cancer Vulnerabilities Unveiled by Genomic Loss

    E-Print Network [OSTI]

    Nijhawan, Deepak

    Due to genome instability, most cancers exhibit loss of regions containing tumor suppressor genes and collateral loss of other genes. To identify cancer-specific vulnerabilities that are the result of copy number losses, ...

  1. Risk of Salivary Gland Cancer After Childhood Cancer: A Report From the Childhood Cancer Survivor Study

    SciTech Connect (OSTI)

    Boukheris, Houda [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Stovall, Marilyn [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Gilbert, Ethel S. [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)] [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States); Stratton, Kayla L. [Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington (United States)] [Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington (United States); Smith, Susan A.; Weathers, Rita [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States)] [Department of Radiation Physics, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Hammond, Sue [Department of Pathology, Ohio State University School of Medicine, Columbus, Ohio (United States)] [Department of Pathology, Ohio State University School of Medicine, Columbus, Ohio (United States); Mertens, Ann C. [Department of Pediatrics, Emory University, Atlanta, Georgia (United States)] [Department of Pediatrics, Emory University, Atlanta, Georgia (United States); Donaldson, Sarah S. [Department of Radiation Oncology, Stanford University Medical Center, Stanford, California (United States)] [Department of Radiation Oncology, Stanford University Medical Center, Stanford, California (United States); Armstrong, Gregory T.; Robison, Leslie L. [Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee (United States)] [Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee (United States); Neglia, Joseph P. [Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota (United States)] [Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota (United States); Inskip, Peter D., E-mail: inskippe@mail.nih.gov [Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (United States)

    2013-03-01T23:59:59.000Z

    Purpose: To evaluate effects of radiation therapy, chemotherapy, cigarette smoking, and alcohol consumption on the risk of second primary salivary gland cancer (SGC) in the Childhood Cancer Survivor Study (CCSS). Methods and Materials: Standardized incidence ratios (SIR) and excess absolute risks (EAR) of SGC in the CCSS were calculated using incidence rates from Surveillance, Epidemiology, and End Results population-based cancer registries. Radiation dose to the salivary glands was estimated based on medical records. Poisson regression was used to assess risks with respect to radiation dose, chemotherapy, smoking, and alcohol consumption. Results: During the time period of the study, 23 cases of SGC were diagnosed among 14,135 childhood cancer survivors. The mean age at diagnosis of the first primary cancer was 8.3 years, and the mean age at SGC diagnosis was 24.8 years. The incidence of SGC was 39-fold higher in the cohort than in the general population (SIR = 39.4; 95% CI = 25.4-57.8). The EAR was 9.8 per 100,000 person-years. Risk increased linearly with radiation dose (excess relative risk = 0.36/Gy; 95% CI = 0.06-2.5) and remained elevated after 20 years. There was no significant trend of increasing risk with increasing dose of chemotherapeutic agents, pack-years of cigarette smoking, or alcohol intake. Conclusion: Although the cumulative incidence of SGC was low, childhood cancer survivors treated with radiation experienced significantly increased risk for at least 2 decades after exposure, and risk was positively associated with radiation dose. Results underscore the importance of long-term follow up of childhood cancer survivors for the development of new malignancies.

  2. Systems Modeling for Prognostic Cancer Biology

    E-Print Network [OSTI]

    Maccabe, Barney

    goal of this research is the development of personalized treatments in cancer, based on the genomic and treatment. A major challenge in contemporary cancer diagnosis and treatment is the development Systems Modeling for Prognostic Cancer Biology Xuefei Wang1 , BaiLian Li2 , Cheryl L. Willman

  3. Breast Cancer Research Finding Answers. Finding Cures.

    E-Print Network [OSTI]

    Kowalczykowski, Stephen C.

    Breast Cancer Research Finding Answers. Finding Cures. Thanks to improvements in treatment and early detection, more and more women are surviving breast cancer. In fact, the five-year survival rate for women with breast cancer today is 90%, up from only 63% in the 1960s. While progress has clearly been

  4. Cancer Epidemiology Population Health Sciences 750

    E-Print Network [OSTI]

    Sheridan, Jennifer

    -01/5/11-1 Cancer Epidemiology Population Health Sciences 750 3 credits When: Spring 2011 (1 Audience: This course is intended for students in health-related disciplines interested in cancer etiology. the unequal burden of cancer among populations and variations across time and geography, 2. the distinctive

  5. Eligibility: Cancer Survivor ages 35-75

    E-Print Network [OSTI]

    Walter, Peter

    Eligibility: · Cancer Survivor ages 35-75 · Patient has completed treatment within last two years for non-metastic solid tumor · Patient's cancer is currently considered stable or in remission · At least. Please contact Missy Buchanan 415-353-7019 for more information. Helen Diller Family Comprehensive Cancer

  6. Upper extremity impairments in women with or without lymphedema following breast cancer treatment

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    following breast cancer treatment Betty Smoot & Josephinefollowing breast cancer treatment, women will demonstratelymphedema. Breast cancer treatments include surgery,

  7. European Journal of Cancer Prevention, vol.8, 1999, Corpet & Gerber, Energy balance and cancer 77 European Journal of Cancer Prevention 1999, 8, 77-89 Author's version

    E-Print Network [OSTI]

    Boyer, Edmond

    European Journal of Cancer Prevention, vol.8, 1999, Corpet & Gerber, Energy balance and cancer 77 European Journal of Cancer Prevention 1999, 8, 77-89 Author's version REVIEW Energy balance and cancers M overweight, have been recognized as risk factors for the development of cancers. Human epidemiological

  8. Provider Communication, Self-Reported Health, and Post-Treatment Regret among Young Breast Cancer Survivors

    E-Print Network [OSTI]

    Fernandes-Taylor, Sara

    2010-01-01T23:59:59.000Z

    R. A. (2004). Breast cancer treatment in older women: impactduring and after cancer treatment: an American Cancerlife following prostate cancer treatment. Cancer Invest, 25(

  9. Assessment of the feasibility of a rehabilitation intervention program for breast cancer survivors with cognitive complaints

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    complaints after breast cancer treatments: examining the2012). Breast Cancer Research and Treatment 135 Wefel, J.STUDIES OF CANCER AND CANCER TREATMENT Assessment of the

  10. Colorectal Cancer Video for the Deaf Community: A Randomized Control Trial

    E-Print Network [OSTI]

    Shabaik, Salma; LaHousse, Sheila F.; Branz, Patricia; Gandhi, Visha; Khan, Amir M.; Sadler, Georgia Robins

    2010-01-01T23:59:59.000Z

    cantly more colorectal cancer knowledge than the controlthe Deaf community about colorectal cancer. KeywordsASL . Cancer prevention . Colorectal cancer . Deaf .

  11. Digital Tomosynthesis: Advanced Breast Cancer

    E-Print Network [OSTI]

    Fygenson, Deborah Kuchnir

    creating an image. · A newer process, called full field digital mammography uses digital receptors. #12Digital Tomosynthesis: Advanced Breast Cancer Imaging Technique Max Wiedmann #12;Digital Bremsstrahlung, a process in which electrons are accelerated against an anode, causing photons to be fired off

  12. DIESEL et CANCER Dominique Lafon

    E-Print Network [OSTI]

    Boyer, Edmond

    1/5 DIESEL et CANCER Dominique Lafon INERIS (*) De nombreuses questions se posent sur la toxicit des missions des moteurs diesel. C'est un sujet qui a beaucoup proccup les scientifiques ces EMISSIONS DU DIESEL. Avant d'aborder la toxicit des missions du diesel, un rappel de leur composition est

  13. Cancer Cell Targeting Androgen Receptor

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    in the development of endo- crine therapies targeting estrogen production or ER for both breast cancer treatment targeting of AR, Wnt or HER2 signaling impairs androgen-stimulated tumor cell growth suggesting potential. Therapies targeting HER2 such as trastuzumab are becoming increasingly important in the treatment of HER2

  14. Predictive and therapeutic markers in ovarian cancer

    SciTech Connect (OSTI)

    Gray, Joe W.; Guan, Yinghui; Kuo, Wen-Lin; Fridlyand, Jane; Mills, Gordon B.

    2013-03-26T23:59:59.000Z

    Cancer markers may be developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genes in the human chromosomal regions, 8q24, 11q13, 20q11-q13, were found to be amplified indicating in vivo drug resistance in diseases such as ovarian cancer. Diagnosis and assessment of amplification levels certain genes shown to be amplified, including PVT1, can be useful in prediction of poor outcome of patient's response and drug resistance in ovarian cancer patients with low survival rates. Certain genes were found to be high priority therapeutic targets by the identification of recurrent aberrations involving genome sequence, copy number and/or gene expression are associated with reduced survival duration in certain diseases and cancers, specifically ovarian cancer. Therapeutics to inhibit amplification and inhibitors of one of these genes, PVT1, target drug resistance in ovarian cancer patients with low survival rates is described.

  15. Shapes of agglomerates in plasma etching reactors Fred Y. Huanga)

    E-Print Network [OSTI]

    Kushner, Mark

    are ion drag, electrostatic, neutral drag, thermophoretic, gravitational, and self-diffusion. Ion drag

  16. Fred H. Rodriguez ('75) Kenneth N. Adatto ('68)

    E-Print Network [OSTI]

    D Bennett P. deBoisblanc ('81) William J. DeFee III ('71) Charles J. III ('87) and Mrs. DePaolo Dr. O, Jr. ('56)* R. Bruce Jordan ('62) William H. Kinnard ('79) Russell C. Klein ('59) David G. Kline, MD) Mark Juneau, Jr. ('73) Russell C. Klein ('59) James J. Leonard ('63) Steve Nelson, MD Dean Earl J

  17. Fred H. Rodriguez ('75) Kenneth N. Adatto ('68)

    E-Print Network [OSTI]

    ) William J. DeFee III ('71) Charles J. III ('87) & Mrs. DePaolo Dr. O.R. ('42)* & Mrs. Depp De, Jr. ('56)* R. Bruce Jordan ('62) P. David Kearns ('79) William H. Kinnard ('79) Russell C. Klein ('59) Mark Juneau, Jr. ('73) Russell C. Klein ('59) James J. Leonard ('63) Steve Nelson, MD - Dean Earl J

  18. Fred H. Rodriguez ('75) Kenneth N. Adatto ('68)

    E-Print Network [OSTI]

    J. Danna ('71) George D. Davis, PhD* Bennett P. deBoisblanc ('81) William J. DeFee, III (`71. Hilton, MD ('98) Patrick A. Hymel, Jr. (98) Frank P. Incaprera ('50) Richard C. Jarrell ('80) Myron H Kearns ('79) William H. Kinnard ('79) Russell C. Klein (`59) David G. Kline, MD Alan D. Lacoste (`75

  19. showcase scheduling at fred astaire east side dance studio

    E-Print Network [OSTI]

    mal92

    2008-04-25T23:59:59.000Z

    As a result, the managers are forced to spend weeks manually constructing and tweaking ... before the showcase, they would still require the managers to spend.

  20. Emergency Response Plan for the Fred Kaiser and Macleod Buildings

    E-Print Network [OSTI]

    Pulfrey, David L.

    with Disabilities - Locations ..............................................10 6 Responsibilities In the Case of Hazardous Material Releases, Spills, Explosions or Fires..27 Building Occupants - Instructions................................................................27 9.1 Explosion or Fire due to Hazardous Materials .........................................27 9

  1. Noel C. MacDonald Fred Kavli Chair for MEMS

    E-Print Network [OSTI]

    California at Santa Barbara, University of

    Micro-mirror Array Ti/Au -Bonding Titanium Waveguide/relay & Wafer scale package Introduction Ti Packaging #12;UCSB 3D Ti MEMS Through- etch titanium wafer Deposit gold on mating surfaces Bond Wafers be processed using power metallurgy. Ti can be joined by fusion welding, brazing, adhesives, diffusion bonding

  2. Fred S. Roberts Command, Control, and Interoperability Center

    E-Print Network [OSTI]

    (CCICADA)* Rutgers University *A Department of Homeland Security University Center of Excellence The Trend For patrons For employees HVAC Communication systems Electronic message boards Public address

  3. Induced Seismicity Consortium (ISC) Fred Aminzadeh, PI, Petroleum Engineering Program

    E-Print Network [OSTI]

    Southern California, University of

    modeling and data analysis capabilities for predicting seismic impacts associated with hydraulic fracturing addresses a very critical and under-developed aspect of environmental safety associated with hydraulic fracturing operations waste water injection and disposal wells, geothermal resource development, and EOR/CO2

  4. Jessica Fred, Residence Life Coordinator Jeff Broggi, Assistant Director

    E-Print Network [OSTI]

    and will determine whether students can sign back into the building. #12; Interactive community with and annual theme from 8pm to 8am Technology > Smart boards, electronic bulletin boards, wireless internet throughout building Great study and social lounge spaces > Building A 1 large study space 1 large lounge space

  5. Dr. Suresh Alahari, the Fred G. Brazda Professor of

    E-Print Network [OSTI]

    ,TX. The cases resulted from the use of portable generators. A portable generator is an internal combustion engine that exhausts a deadly gas called They represent "new faces doing noteworthy activities or

  6. News Release Media Contact: Fred Strohl (strohlhf@ornl.gov)

    E-Print Network [OSTI]

    energy efficient buildings, including a house and a community center. As part of the segment, Energy to achieve as near zero energy design as we could." Christian hopes the estimated 15 million people who for Americans to make in their own homes," Christian said. "The goal is to move as close to zero energy

  7. What can data provide for HLbL ? Fred Jegerlehner

    E-Print Network [OSTI]

    Rder, Beate

    polarization tensor (q1, q2, q3) = d4 x1 d4 x2 d4 x3 ei (q1x1+q2x2+q3x3) 0 | T{ j(x1) j(x2) j(x3) j(0)} | 0 (0, s1, s2)plane Two scale problem: "open regions" RLA ??? ??? pQCD One scale problem: "no problem

  8. Emergency Response Plan for the Fred Kaiser and Macleod Buildings

    E-Print Network [OSTI]

    Pulfrey, David L.

    Walk 604.822.5355 Campus Security 604.822.2222 Fire Prevention (City of Vancouver Inquiry Line) 311 RCMP 6 3.2 Emergency Lighting 6 3.3 Emergency Power 6 3.4 Fire Alarm System 6 3.5 Fire Extinguisher(s) 7 Department 604.822.7662 (8:00 Am 5:00 PM only) Poison Control Centre 604.682.5050 Campus Security 604

  9. Agent Program Planning Information Fathers Reading Every Day (FRED)

    E-Print Network [OSTI]

    are held at child care centers, elementary schools, public libraries, school libraries, and churchesMeeting training conducted by Dr. Stephen Green in the fall of 2013. The training will recorded and posted on Agri

  10. FRED - Q & A | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual SiteofEvaluating A PotentialJumpGerman AerospaceEfficiency Incentives and Policies |FPEFR

  11. FRED+free energy database | OpenEI Community

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual SiteofEvaluating A PotentialJumpGerman AerospaceEfficiency Incentives and PoliciesHomeno

  12. Introducing FRED, Enabling Unique Visualization and Manipulation of Energy

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directedAnnual Siteof Energy 2,AUDIT REPORTEnergyFarmsPower Co Ltd JumpInformationInterstromData at

  13. OpenEI Community - FRED+free energy database

    Open Energy Info (EERE)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are beingZealand Jump to: navigation, searchOfRoseConcernsCompany Oil and GasOff the GridHome All0 enTeam! Welcome to

  14. Mr. Fred Steinkuehler Granite City Steel Division National Steel Corporation

    Office of Legacy Management (LM)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645 3,625 1,006 492 742EnergyOn AprilA groupTuba City, Arizona, DisposalFourth Five-Year38Report3Department of Energy

  15. Cancer in Ireland 1994-2004: A comprehensive report

    E-Print Network [OSTI]

    Müller, Jens-Dominik

    Cancer in Ireland 1994-2004: A comprehensive report A report of cancer incidence, mortality AT and Comber H. Cancer in Ireland 1994-2004: A comprehensive report. Northern Ireland Cancer Registry/National Cancer Registry, Ireland; 2009 #12;#12;NICR/NCRI Contents...i Contents Contents

  16. PrincetonUniversity In-Vitro Studies of Cancer

    E-Print Network [OSTI]

    Petta, Jason

    PrincetonUniversity In-Vitro Studies of Cancer Cell Death Due to Hyperthermia C. Barkey1, RUniversity Cancer: Facts and Figures World Wide 10.1 million newly diagnoses/year with ~10% increase 6.2 million deaths are attributed to cancer and its complication each year American Cancer Society 2007 and Le Cancer

  17. High Throughput Analysis of Breast Cancer Specimens on the Grid

    E-Print Network [OSTI]

    cancer accounts for about 30% of all cancers and 15% of all cancer deaths in women in the United States in the United States. Women living in North America have the highest rate of breast cancer in the world [1]. In spite of the increase in the incidence of the disease, the death rates of breast cancer continue

  18. Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 1

    E-Print Network [OSTI]

    Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 1 2012 INTERNAL USER GUIDE A Guide to the Cancer Research UK electronic Grants Management System (e://egms.cancerresearchuk.org #12;Cancer Research UK eGMS Applicant Guide Cancer Research UK (eGMS) applicant guide June 2012 Page 2

  19. Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam

    E-Print Network [OSTI]

    Petta, Jason

    Cancer: Detect and DestroyCancer: Detect and Destroy PrincetonPrinceton iGEMiGEM TeamTeam PresentedPresentation Overview What is Synthetic Biology?What is Synthetic Biology? ProjectProject Cancer: Detect and DestroyCancer regeneration Diabetes Cancer therapy Artificial immune system Environmental Biosensing Environmental

  20. Genome Science and Personalized Cancer Treatment

    ScienceCinema (OSTI)

    Joe Gray

    2010-01-08T23:59:59.000Z

    August 4, 2009 Berkeley Lab lecture: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

  1. age gastric cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    tumour marker in patients with gastric cancer. unknown authors 2 The effect of gender on Helicobacter pylori and gastric cancer MIT - DSpace Summary: Gastric cancer is the 2nd...

  2. advanced gastric cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    tumour marker in patients with gastric cancer. unknown authors 2 The effect of gender on Helicobacter pylori and gastric cancer MIT - DSpace Summary: Gastric cancer is the 2nd...

  3. aggressive gastric cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    tumour marker in patients with gastric cancer. unknown authors 2 The effect of gender on Helicobacter pylori and gastric cancer MIT - DSpace Summary: Gastric cancer is the 2nd...

  4. Microwave imaging for ultra-wideband antenna based cancer detection

    E-Print Network [OSTI]

    Zhang, Haoyu

    2015-06-29T23:59:59.000Z

    Breast cancer is one of the most widespread types of cancer in the world. The key factor in treatment is to reliably diagnose the cancer in the early stages. Moreover, currently used clinical diagnostic methods, such as ...

  5. The genomic complexity of primary human prostate cancer

    E-Print Network [OSTI]

    Carter, Scott Lambert

    Prostate cancer is the second most common cause of male cancer deaths in the United States. However, the full range of prostate cancer genomic alterations is incompletely characterized. Here we present the complete sequence ...

  6. Perspectives on the mesenchymal origin of metastatic cancer

    E-Print Network [OSTI]

    Huysentruyt, Leanne C.; Seyfried, Thomas N.

    2010-01-01T23:59:59.000Z

    of metastasis. Nature Reviews Cancer, 9(4), 239252. 12.M. , & Kovarik, J. (1987). Is cancer a macrophage- mediatedof secondary growths in cancer of the breast. Lancet, 1,

  7. Modern mathematics for modern cancer medicine ACC Coolen, July 2013 Modern Mathematics for Modern Cancer Medicine

    E-Print Network [OSTI]

    Coolen, ACC "Ton"

    by developing advanced quantitative techniques, and applying them to cancer data analysis, outcome and treatment individual treatment response, and low success rates of medical trials. To extend and save lives of cancer of good or poor cancer outcomes, of response to specific treatments, or of metastasis sites. Unfortunately

  8. Nutrition and Cancer 1998, 32 (3) 165 NUTRITION AND CANCER 1998, 32 (3),165-173.

    E-Print Network [OSTI]

    Boyer, Edmond

    or processed meat is associated with increased risk of colon cancer. In contrast, consumption of white meat supplied by 1) lard and casein, 2) olive oil and casein, 3) beef, 4) chicken with skin, and 5) bacon. Meat, France. Introduction Colorectal cancer is the second most common cause of death from cancer

  9. Prostate cancer remains the most common cancer in men in the United States, with an

    E-Print Network [OSTI]

    Cai, Long

    Prostate cancer remains the most common cancer in men in the United States, with an estimated of death from cancer in men, with 33,720 estimated deaths (11% of all estimated deaths) in 2011 (REF. 1-year relative survival rate is essentially 100% based on 20012007 statistics2 . However, for patients

  10. The National Cancer Survivorship Initiative: new and emerging evidence on the ongoing needs of cancer survivors

    E-Print Network [OSTI]

    Quartly, Graham

    ; #12; A key commitment of the Cancer Reform Strategy (Department of Health, 2007) in UK, and endorsed Floor Portland House, Bressenden Place, London SW1E 5RS, UK; 2 Faculty of Health Sciences, University in Improving Outcomes Strategy for Cancer (Department of Health, 2011), was to establish a National Cancer

  11. Eur J Cancer Prev. Author manuscript Determinants of non-compliance to recommendations on breast cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Eur J Cancer Prev. Author manuscript Page /1 11 Determinants of non-compliance to recommendations on breast cancer screening among women participating in the French E3N cohort study Flamant Camille , Gauthier Estelle , Clavel-Chapelon Fran oiseç * E3N, Nutrition, hormones et cancer: pid miologie et pr

  12. J. Clairambault Theorems to treat cancer? Can theorems help treat cancer?

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    J. Clairambault Theorems to treat cancer? Can theorems help treat cancer? Jean Clairambault 1 INRIA who treat patients with can- cer? Can mathematics have an impact on cancer biology? Is mathematics more than just a tool in the hands of [a few open-minded] physicians willing to understand and treat

  13. Cutaneous cancers in Calabar, Southern Nigeria

    E-Print Network [OSTI]

    Asuquo, Maurice E; Ebughe, Godwin

    2009-01-01T23:59:59.000Z

    Skin cancer in Zaria, Nigeria. Trop Doct 1995; 25(Suppl. ):Malignancies in Kano, Northern Nigeria: A histopathologicalequatorial rain forest of Nigeria. International Journal of

  14. Cancer survivorship research: the challenge of recruiting adult long term cancer survivors from a cooperative clinical trials group

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    quality of life among long-term survivors of breast cancer.Breast Cancer Res Treat. 1996;39(3):26173. doi:B, Bower JE. Breast Cancer in Younger Women: Reproductive

  15. This issue of the Stanford Cancer Institute Clinical Research Newsletter is focused on our multi-disciplinary Women's Cancer and Urologic Cancer Programs.

    E-Print Network [OSTI]

    Sonnenburg, Justin L.

    's cancer. In addition to cancer treatment, supportive services--including social services, psychological of the triple negative breast cancer. The Stanford Gynecologic Oncology Program offers treatments and clinical Group (COGi), a national cooperative research group for innovative treatments in ovarian cancer

  16. advanced colon cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    from multiple specialties work together under Engineering Websites Summary: BREAST CANCER PROGRAM A team of breast cancer experts from multiple specialties work together under...

  17. Isotope production facility produces cancer-fighting actinium

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer therapy gets a boost from new isotope Isotope production facility produces cancer-fighting actinium A new medical isotope project shows promise for rapidly producing major...

  18. Sensitive Immunosensor for Cancer Biomarker Based on Dual Signal...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Immunosensor for Cancer Biomarker Based on Dual Signal Amplification Strategy of Graphene Sheets and Multi-Enzyme Sensitive Immunosensor for Cancer Biomarker Based on Dual Signal...

  19. Endoscopic Electron-Beam Cancer Therapy | Argonne National Laboratory

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Endoscopic Electron-Beam Cancer Therapy Technology available for licensing: A successful and cost-effective means of treating cancer in previously inoperable or radiation-sensitive...

  20. DOE Laboratories Help Develop Promising New Cancer Fighting Drug...

    Office of Environmental Management (EM)

    Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib DOE Laboratories Help Develop Promising New Cancer Fighting Drug, Vemurafenib August 18, 2011 - 1:03pm...

  1. Proteogenomic characterization of human colon and rectal cancer...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    characterization of human colon and rectal cancer. Proteogenomic characterization of human colon and rectal cancer. Abstract: We analyzed proteomes of colon and rectal tumors...

  2. Biocompatible core-shell magnetic nanoparticles for cancer treatment...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Biocompatible core-shell magnetic nanoparticles for cancer treatment. Biocompatible core-shell magnetic nanoparticles for cancer treatment. Abstract: Non-toxic magnetic...

  3. Blood Peptidome-Degradome Profile of Breast Cancer. | EMSL

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Blood Peptidome-Degradome Profile of Breast Cancer. Blood Peptidome-Degradome Profile of Breast Cancer. Abstract: We report on the degradomic-peptidomic insights into blood plasma...

  4. Searching for a system: The quest for ovarian cancer biomarkers...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Searching for a system: The quest for ovarian cancer biomarkers. Searching for a system: The quest for ovarian cancer biomarkers. Abstract: The stark difference in clinical outcome...

  5. advanced bladder cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer Mortality Kenneth G. Brown; Barbara D. Beck; Claudia Hopenhayn-Rich; Mary Lou Biggs; Allan H. Smith Biology and Medicine Websites Summary: Arsenic and Bladder Cancer...

  6. adult cancer patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer Center's Adult Patient & Family Advisory Council Page 1 of 3 and compassionate health care provided by Dana-FarberBrigham and Women's Cancer Center. Working in active...

  7. Nanotechnology in Cancer Treatment and Detection Richard Acosta

    E-Print Network [OSTI]

    Fygenson, Deborah Kuchnir

    Nanotechnology in Cancer Treatment and Detection Richard Acosta #12;Motivation Ineffectiveness or roughly 100 times smaller than most human cells Cancer Nanotechnology research is interdisciplinary

  8. Drug-drug similarity networks for anti-cancer drug discovery Case studies on Breast Cancer, Colorectal Cancer and Leukemia

    E-Print Network [OSTI]

    Zhou, Yaoqi

    Drug-drug similarity networks for anti-cancer drug discovery Case studies on Breast Cancer the decades, the medical industry has been challenged with the issue of producing drugs that would avoid sidetracking to other targets (off-targets) and keep away from harmful side effects (drug adverse reactions

  9. Early Growth Response 3 (Egr3) Is Highly Over-Expressed in Non-Relapsing Prostate Cancer but Not in Relapsing Prostate Cancer

    E-Print Network [OSTI]

    Pio, Rebecca; Jia, Zhenyu; Baron, Veronique T; Mercola, Dan; Agoulnik, Irina U

    2013-01-01T23:59:59.000Z

    company developing prostate cancer related tests. Dr. Barontherapy for prostate cancer. There are no marketed productsand prognosis of prostate cancer. September 2011: US

  10. Diet and Cancer Are Cooked Meats Involved

    ScienceCinema (OSTI)

    LLNL - University of California Television

    2009-09-01T23:59:59.000Z

    Diet has been associated with differences in cancer rates in human populations for many years. Mark Knize presents the latest research on cancer causes including work performed at Lawrence Livermore National Laboratory investigating some interesting chemical products created when meat is cooked and how to reduce them. Series: Science on Saturday [10/2006] [Health and Medicine] [Science] [Show ID: 11542

  11. EDITORIAL Open Access Toward integrative cancer immunotherapy

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    alterations of normal host cells. Accordingly, the aim of most traditional cancer therapies has been to destroy the transformed cells themselves. There is now widespread appreciation that the progressive growth and metastatic spread of cancer cells requires the cooperation of normal host cells (endothelial cells

  12. Restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, M.J.; Weaver, V.M.

    1998-12-08T23:59:59.000Z

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying {beta}{sub 1} integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive. 14 figs.

  13. Restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, Mina J. (Berkeley, CA); Weaver, Valerie M. (Oakland, CA)

    1998-01-01T23:59:59.000Z

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

  14. Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: Results from three US population-based case-control studies of ovarian cancer

    SciTech Connect (OSTI)

    Whittemore, A.S.; Gong, G.; Itnyre, J. [Stanford Univ. School of Medicine, CA (United States)

    1997-03-01T23:59:59.000Z

    We investigate the familial risks of cancers of the breast and ovary, using data pooled from three population-based case-control studies of ovarian cancer that were conducted in the United States. We base estimates of the frequency of mutations of BRCA1 (and possibly other genes) on the reported occurrence of breast cancer and ovarian cancer in the mothers and sisters of 922 women with incident ovarian cancer (cases) and in 922 women with no history of ovarian cancer (controls). Segregation analysis and goodness-of-fit testing of genetic models suggest that rare mutations (frequency .0014; 95% confidence interval .0002-.011) account for all the observed aggregation of breast cancer and ovarian cancer in these families. The estimated risk of breast cancer by age 80 years is 73.5% in mutation carriers and 6.8% in noncarriers. The corresponding estimates for ovarian cancer are 27.8% in carriers and 1.8% in noncarriers. For cancer risk in carriers, these estimates are lower than those obtained from families selected for high cancer prevalence. The estimated proportion of all U.S. cancer diagnoses, by age 80 years, that are due to germ-line BRCA1 mutations is 3.0% for breast cancer and 4.4% for ovarian cancer. Aggregation of breast cancer and ovarian cancer was less evident in the families of 169 cases with borderline ovarian cancers than in the families of cases with invasive cancers. Familial aggregation did not differ by the ethnicity of the probands, although the number of non-White and Hispanic cases (N = 99) was sparse. 14 refs., 3 figs., 6 tabs.

  15. The use of complementary and alternative medicine among breast cancer survivors : the women's healthy eating and living study perspective

    E-Print Network [OSTI]

    Saquib, Juliann

    2010-01-01T23:59:59.000Z

    disparities in breast cancer treatment. J Clin Oncol 2007;based trends in cancer treatment. J Natl Cancer Inst 2005;use systemic cancer treatments across tumor characteristics

  16. Contacts @CRCTUCRCTU Cancer Research UK Clinical Trials Unit

    E-Print Network [OSTI]

    Birmingham, University of

    treatments and biomarkers for cancer. The CRCTU also collaborate with a large number of academic scientificContacts @CRCTUCRCTU Cancer Research UK Clinical Trials Unit School of Cancer Sciences University://www.birmingham.ac.uk/crctu Making a difference... A National Cancer Research Institute Accredited Trials Unit Linked Groups

  17. Contacts @CRCTUCRCTU Cancer Research UK Clinical Trials Unit

    E-Print Network [OSTI]

    Birmingham, University of

    scientists in the development of new treatments and biomarkers for cancer. The CRCTU also collaborateContacts @CRCTUCRCTU Cancer Research UK Clinical Trials Unit School of Cancer Sciences University... A National Cancer Research Institute Accredited Trials Unit Linked Groups @CRCTUCRCTU Birmingham

  18. Cancer is a genetic disease1 . Although environmental

    E-Print Network [OSTI]

    Nowak, Martin A.

    Cancer is a genetic disease1 . Although environmental and other non-genetic factors have roles in many stages of tumorigenesis,it is widely accepted that cancer arises because of mutations in cancer,however,does not suffice to give rise to full-blown cancer.For progression towards malignancyandinvasion

  19. Metabolism and proliferation share common regulatory pathways in cancer

    E-Print Network [OSTI]

    Boyer, Edmond

    Metabolism and proliferation share common regulatory pathways in cancer cells. Vanessa Fritz, proliferation, and cancer inserm-00491405,version1-11Jun2010 Author manuscript, published in "Oncogene 2010;29(31):4369-77" DOI : 10.1038/onc.2010.182 #12;Metabolism, proliferation and cancer Fritz and Fajas 2 Abstract Cancer

  20. Cancer Cells DOI: 10.1002/anie.201103189

    E-Print Network [OSTI]

    Zhang, Liangfang

    Cancer Cells DOI: 10.1002/anie.201103189 Self-Propelled Microrockets to Capture and Isolate Circulating Tumor Cells Weiwei Gao and Omid C. Farokhzad* cancer · micromachines · nanorobots · nanotechnology metastatic cancer.[1] Since then cancer research has proved the critical roles played by CTC

  1. lung cancer smoke-free 6 One man's

    E-Print Network [OSTI]

    Roy, Subrata

    Fighting lung cancer Living smoke-free 6 One man's mission85 #12;Cure is the newsletter for the University of Florida Shands Cancer Center, home to cancer care and research for the Southeast's most? For more information about care and services offered at the UF Shands Cancer Center, call 352

  2. "Skin Cancer-What to Look For" Rochester Recreation

    E-Print Network [OSTI]

    Goldman, Steven A.

    "Skin Cancer- What to Look For" Rochester Recreation Club for the Deaf May 20, 2010 #12;Supporters for the Deaf ("REAP") #12;Overview Skin Overview What is skin cancer? Who is at risk? How common is skin cancer? Signs of skin cancer Prevention Treatments #12;Skin Overview Skin is the largest organ in your body

  3. Cancer Cells DOI: 10.1002/anie.201100115

    E-Print Network [OSTI]

    Zhang, Liangfang

    Cancer Cells DOI: 10.1002/anie.201100115 Micromachine-Enabled Capture and Isolation of Cancer Cells (CTCs) are the primary entities responsible for spawning cancer metastasis. Detection of CTCs provides an indicator for the clinical diagnosis and prognosis of various types of cancers. Several approaches, based

  4. SUPPLEMENTAL FUNDING ANNOUNCEMENT CAREER DEVELOPMENT AWARD IN MELANOMA & SKIN CANCER

    E-Print Network [OSTI]

    Sibille, Etienne

    SUPPLEMENTAL FUNDING ANNOUNCEMENT CAREER DEVELOPMENT AWARD IN MELANOMA & SKIN CANCER Sponsored by: The Specialized Program of Research Excellence (SPORE) in Melanoma & Skin Cancer University of Pittsburgh Cancer Institute Purpose The overall goals of the Melanoma & Skin Cancer SPORE are to improve the detection

  5. FUNDING ANNOUNCEMENT CAREER DEVELOPMENT AWARD IN MELANOMA & SKIN CANCER

    E-Print Network [OSTI]

    Sibille, Etienne

    FUNDING ANNOUNCEMENT CAREER DEVELOPMENT AWARD IN MELANOMA & SKIN CANCER Sponsored by: The Specialized Program of Research Excellence (SPORE) in Melanoma & Skin Cancer University of Pittsburgh Cancer Institute (UPCI) Purpose The overall goals of the Melanoma & Skin Cancer SPORE are to improve the detection

  6. IN A CUREUF HEALTH CANCER CENTER NEWS SPRING 2014

    E-Print Network [OSTI]

    Roy, Subrata

    care and research for the Southeast's most comprehensive academic health center. In each issue, weIN A CUREUF HEALTH CANCER CENTER NEWS Believe SPRING 2014 PAGE6 #12;www.cancer.ufl.eduBelieve in a Cure//Spring 20142 Believe in a Cure is the newsletter for the UF Health Cancer Center, home to cancer

  7. AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention

    E-Print Network [OSTI]

    Kaski, Samuel

    AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention What are the chances that I will develop lung cancer? The #1 cause of lung cancer is exposure to tobacco smoke. Your chances increase others (second-hand smoke), the greater your chances of developing lung cancer. People who have never

  8. Radio Sensors to Help Detect Cancer Monday, July 28, 2008 -Anni Shaer Levitt

    E-Print Network [OSTI]

    Chiao, Jung-Chih

    , Treatments & Facts on Breast Cancer Cancers Acid Reflux Causes Cancer A free, informative online video.RefluxRemedy.com American Cancer Society Get the latest information on stomach cancer treatments www.cancerSearch Home Headlines News Articles Forums Radio Sensors to Help Detect Cancer Monday, July 28

  9. An online survey to find out how people manage cancer and cancer related problems in the 12

    E-Print Network [OSTI]

    Anderson, Jim

    following initial cancer treatment There are around two million people in the UK living with or beyond cancer and this number is rising by more than 3% per year. Treatments for cancer such as chemotherapy manage most problems associated with cancer and its treatment on their own as part of their daily lives

  10. Abstract. Breast cancer is the most common cancer in women worldwide. Transformation of a normal cell to a malignant one

    E-Print Network [OSTI]

    Abstract. Breast cancer is the most common cancer in women worldwide. Transformation of a normal regulators of growth. Biomarkers associated with cancer were examined in human breast epithelial cells transformed by high-LET radiation in the presence of 17?-estradiol. An established cancer model was used

  11. doi:10.1016/j.ijrobp.2006.02.044 INDUCED SECOND CANCERS AFTER PROSTATE-CANCER

    E-Print Network [OSTI]

    Brenner, David Jonathan

    doi:10.1016/j.ijrobp.2006.02.044 EDITORIAL INDUCED SECOND CANCERS AFTER PROSTATE-CANCER University Medical Center, New York, NY The absolute risks of a radiation-induced second cancer among long concern, expressed by Kendal et al. (5) in this issue, that prostate cancer patients may be unduly

  12. Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells

    E-Print Network [OSTI]

    Wahl, Geoffrey M.

    Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Hospital for Sick Children, Toronto, Ontario, Canada; 4 Terry Fox Laboratory BC Cancer Research Center, Vancouver, British Columbia, Canada; 5 Moores University of California San Diego Cancer Center; 6 The Salk

  13. A Framework for Developing, Implementing, and Evaluating a Cancer Survivorship Curriculum for Medical Students

    E-Print Network [OSTI]

    Uijtdehaage, Sebastian; Hauer, Karen E.; Stuber, Margaret; Rajagopalan, Shobita; Go, Vay L.; Wilkerson, LuAnn

    2009-01-01T23:59:59.000Z

    the impact of cancer and treatment on their relation- ships,term consequences of cancer treatments. Furthermore, whileincluding details of cancer treatment and follow-up. In

  14. Cancer survivors and survivorship care: Provider expectations, post-treatment health services, and patient reported outcomes

    E-Print Network [OSTI]

    Hahn, Erin Elizabeth

    2013-01-01T23:59:59.000Z

    you heard about cancer treatment summaries or survivorshipthe course of breast cancer treatment should patients beginduring their active cancer treatment (surgery, radiation,

  15. Breast cancer detection using automated whole breast ultrasound and mammography in radiographically dense breasts

    E-Print Network [OSTI]

    Kelly, KM; Dean, J; Comulada, WS; Lee, S-J

    2010-01-01T23:59:59.000Z

    at high risk for breast cancer with MR imaging. Breast Can-Findings from the Breast Cancer Surveillance Consortium:women undergoing biopsy after screening mammography. Cancer

  16. Breast cancer screening disparities among ethnically diverse women in California : a latent profile analysis

    E-Print Network [OSTI]

    Gerry, Arianna Aldridge

    2011-01-01T23:59:59.000Z

    1998). Reducing cervical cancer among First Nations women.K. , & Edwards, B.K. (2002). Cancer survival among US whitestreatment of primary breast cancer: A systematic review.

  17. Lung Cancer as a Second Primary Malignancy: Increasing Prevalence and Its Influence on Survival

    E-Print Network [OSTI]

    Quadrelli, Silvia; Lyons, Gustavo; Colt, Henri; Chimondeguy, Domingo; Silva, Carlos

    2009-01-01T23:59:59.000Z

    therapy for multiple primary lung cancers. Chest. REFERENCEMR. Multiple primary lung cancers. J Thorac Cardiovasc Surg.60612. 2. Johnson BE. Second lung cancers in patients after

  18. Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    Molecular pathogenesis of lung cancer, Annual Review ofp63 immunoreac- tivity in lung cancer: yet another player inprotein-related genes in lung cancer: correlation with drug

  19. advanced head-and-neck cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    in skin cancer, colorectal carcinoma, testicular teratoma and liver cancer types: brain, breast, head and neck, renal, skin and testicular cancers. Conclusions: SULF1 and...

  20. Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

    E-Print Network [OSTI]

    Fendt, Sarah-Maria

    Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with increased survival in patients with cancer taking metformin; however, the mechanism by which metformin improves cancer ...

  1. Micro and nanotechnology for cancer treatment

    E-Print Network [OSTI]

    Ullal, Adeeti (Adeeti Vedantham)

    2013-01-01T23:59:59.000Z

    Cancer is responsible for over 7.6 million deaths worldwide; the majority of patients fail to respond to drugs or become resistant over time. In order to gain a better understanding of drug efficacy in patients, we developed ...

  2. Near infrared optical lymphography for cancer diagnostics

    E-Print Network [OSTI]

    Houston, Jessica Perea

    2007-04-25T23:59:59.000Z

    A new molecular imaging modality has been developed to detect and locate positive axillary and sentinel lymph nodes non-invasively in breast cancer patients undergoing lymphoscintigraphy. The modality is based on fluorescent photon detection...

  3. Intestinal cancer : linking infection, inflammation and neoplasia

    E-Print Network [OSTI]

    Sohn, Jane Joo-hee, 1976-

    2005-01-01T23:59:59.000Z

    Cancer is a leading cause of death in the world. Much work has been done to study the role of inflammation in carcinogenesis. One hypothesis suggests that inflammation causes oxidative stress that induces damage to cellular ...

  4. Breast Density and Cancer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Breast Cancer Awareness Series: Understanding Breast Density Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in...

  5. Investigation into taxane resistant breast cancer

    E-Print Network [OSTI]

    Kenicer, Juliet Elisabeth Margaret

    2011-11-25T23:59:59.000Z

    One group of chemotherapeutics that are used successfully to treat breast cancer, alone or in combination with other agents, are the taxanes; paclitaxel and docetaxel. They act by interfering with the spindle microtubule ...

  6. Regulatory roles of endothelial cells in cancer

    E-Print Network [OSTI]

    Franses, Joseph W. (Joseph Wang)

    2011-01-01T23:59:59.000Z

    This thesis describes the biochemical regulatory impact of endothelial cells, the cells that line all blood vessels, in cancer. Our work draws from concepts in vascular repair and tissue engineering and extends the view ...

  7. Focus on the Physics of Cancer

    E-Print Network [OSTI]

    Risler, Thomas

    2015-01-01T23:59:59.000Z

    Despite the spectacular achievements of molecular biology in the second half of the twentieth century and the crucial advances it permitted in cancer research, the fight against cancer has brought some disillusions. It is nowadays more and more apparent that getting a global picture of the very diverse and interlinked aspects of cancer development necessitates, in synergy with these achievements, other perspectives and investigating tools. In this undertaking, multidisciplinary approaches that include quantitative sciences in general and physics in particular play a crucial role. This `focus on' collection contains 19 articles representative of the diversity and state-of-the-art of the contributions that physics can bring to the field of cancer research.

  8. Cancer Cell Metabolism: One Hallmark, Many Faces

    E-Print Network [OSTI]

    Sabatini, David M.

    Cancer cells must rewire cellular metabolism to satisfy the demands of growth and proliferation. Although many of the metabolic alterations are largely similar to those in normal proliferating cells, they are aberrantly ...

  9. Regulation of apoptosis in human cancer cells

    E-Print Network [OSTI]

    Lloyd, S. Julie-Ann (Simone Julie-Ann)

    2005-01-01T23:59:59.000Z

    Nitric oxide is postulated to protect cancer cells from the death-inducing effects of tumour necrosis factor alpha by S-nitrosating the active site cysteines, inhibiting cleavage of caspase-9. We aimed to test this hypothesis ...

  10. Somatic retrotransposition in the cancer genome

    E-Print Network [OSTI]

    Helman, Elena

    2014-01-01T23:59:59.000Z

    Cancer is a complex disease of the genome exhibiting myriad somatic mutations, from single nucleotide changes to various chromosomal rearrangements. The technological advances of next-generation sequencing enable high-throughput ...

  11. Prof. Ian H. Hutchinson Professor of Nuclear Science and Engineering, MIT.

    E-Print Network [OSTI]

    Chen, Sow-Hsin

    ) is Professor of Nuclear Science and Engineering at the Massachusetts Institute of Technology. His primary configuration, the Reversed Field Pinch, with the U.K. Atomic En- ergy Authority, where he made landmark

  12. Monolithically integrated InP-based tunable wavelength conversion John M. Hutchinson*1

    E-Print Network [OSTI]

    Coldren, Larry A.

    The simplest photocurrent-driven wavelength converter (PD-WC) consists of a photodiode receiver directly such as implemented in the sampled-gating distributed Bragg reflector (SGDBR) laser [10]. A separate DC electrode

  13. Chapter 27 -- Breast Cancer Genomics, Section VI, Pathology and Biological Markers of Invasive Breast Cancer

    SciTech Connect (OSTI)

    Spellman, Paul T.; Heiser, Laura; Gray, Joe W.

    2009-06-18T23:59:59.000Z

    Breast cancer is predominantly a disease of the genome with cancers arising and progressing through accumulation of aberrations that alter the genome - by changing DNA sequence, copy number, and structure in ways that that contribute to diverse aspects of cancer pathophysiology. Classic examples of genomic events that contribute to breast cancer pathophysiology include inherited mutations in BRCA1, BRCA2, TP53, and CHK2 that contribute to the initiation of breast cancer, amplification of ERBB2 (formerly HER2) and mutations of elements of the PI3-kinase pathway that activate aspects of epidermal growth factor receptor (EGFR) signaling and deletion of CDKN2A/B that contributes to cell cycle deregulation and genome instability. It is now apparent that accumulation of these aberrations is a time-dependent process that accelerates with age. Although American women living to an age of 85 have a 1 in 8 chance of developing breast cancer, the incidence of cancer in women younger than 30 years is uncommon. This is consistent with a multistep cancer progression model whereby mutation and selection drive the tumor's development, analogous to traditional Darwinian evolution. In the case of cancer, the driving events are changes in sequence, copy number, and structure of DNA and alterations in chromatin structure or other epigenetic marks. Our understanding of the genetic, genomic, and epigenomic events that influence the development and progression of breast cancer is increasing at a remarkable rate through application of powerful analysis tools that enable genome-wide analysis of DNA sequence and structure, copy number, allelic loss, and epigenomic modification. Application of these techniques to elucidation of the nature and timing of these events is enriching our understanding of mechanisms that increase breast cancer susceptibility, enable tumor initiation and progression to metastatic disease, and determine therapeutic response or resistance. These studies also reveal the molecular differences between cancer and normal that may be exploited to therapeutic benefit or that provide targets for molecular assays that may enable early cancer detection, and predict individual disease progression or response to treatment. This chapter reviews current and future directions in genome analysis and summarizes studies that provide insights into breast cancer pathophysiology or that suggest strategies to improve breast cancer management.

  14. Radiation Dose and Subsequent Risk for Stomach Cancer in Long-term Survivors of Cervical Cancer

    SciTech Connect (OSTI)

    Kleinerman, Ruth A., E-mail: kleinerr@mail.nih.gov [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland (United States); Smith, Susan A. [Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Holowaty, Eric [Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario (Canada); Hall, Per [Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm (Sweden); Pukkala, Eero [Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki (Finland); Vaalavirta, Leila [Department of Oncology, Helsinki University Central Hospital, Helsinki (Finland); Stovall, Marilyn; Weathers, Rita [Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, Texas (United States); Gilbert, Ethel [Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Rockville, Maryland (United States); Aleman, Berthe M.P. [Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam (Netherlands); Kaijser, Magnus [Clinical Epidemiology Unit, Department of Medicine, Karolinska Institute, Stockholm (Sweden); Andersson, Michael [Department of Oncology, Copenhagen University Hospital, Copenhagen (Denmark); Storm, Hans [Cancer Prevention and Documentation, Danish Cancer Society, Copenhagen (Denmark); Joensuu, Heikki [Department of Oncology, Helsinki University Central Hospital, Helsinki (Finland); Lynch, Charles F. [Department of Epidemiology, University of Iowa, Iowa City, Iowa (United States); and others

    2013-08-01T23:59:59.000Z

    Purpose: To assess the doseresponse relationship for stomach cancer after radiation therapy for cervical cancer. Methods and Materials: We conducted a nested, matched casecontrol study of 201 cases and 378 controls among 53,547 5-year survivors of cervical cancer diagnosed from 1943 to 1995, from 5 international, population-based cancer registries. We estimated individual radiation doses to the site of the stomach cancer for all cases and to corresponding sites for the matched controls (overall mean stomach tumor dose, 2.56 Gy, range 0.03-46.1 and after parallel opposed pelvic fields, 1.63 Gy, range 0.12-6.3). Results: More than 90% of women received radiation therapy, mostly with external beam therapy in combination with brachytherapy. Stomach cancer risk was nonsignificantly increased (odds ratio 1.27-2.28) for women receiving between 0.5 and 4.9 Gy to the stomach cancer site and significantly increased at doses ?5 Gy (odds ratio 4.20, 95% confidence interval 1.41-13.4, P{sub trend}=.047) compared with nonirradiated women. A highly significant radiation doseresponse relationship was evident when analyses were restricted to the 131 cases (251 controls) whose stomach cancer was located in the middle and lower portions of the stomach (P{sub trend}=.003), whereas there was no indication of increasing risk with increasing dose for 30 cases (57 controls) whose cancer was located in the upper stomach (P{sub trend}=.23). Conclusions: Our findings show for the first time a significant linear doseresponse relationship for risk of stomach cancer in long-term survivors of cervical cancer.

  15. Dana-Farber Cancer Institute About Dana-Farber Cancer Institute

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    ;About the Jimmy Fund The Jimmy Fund raises vital funds to support adult and pediatric cancer care and research at Dana-Farber exclusively. Since 1948, the generosity of millions of people has helped the Jimmy Fund save countless lives and reduce the burden of cancer. The Jimmy Fund has: · raised more than $948

  16. Lung Cancer: A Classic Example of Tumor Escape and Progression While Providing Opportunities for Immunological Intervention

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    of lung cancer, Clinical Cancer Research, vol. 4, no. 7,pathogenesis of lung cancer, Annual Review of Physiology,immunoreac- tivity in lung cancer: yet another player in the

  17. Sports activities and risk of testicular cancer

    E-Print Network [OSTI]

    A. J. Coldman; J. M. Elwooda; R. P. Gallagher; Nottingham Nottingham

    1982-01-01T23:59:59.000Z

    Summary.-The relationship of testicular seminoma with several factors was explored using a case-control study. Previously recognized associations with cryptorchidism and infantile inguinal hernia were confirmed and relationships were also found with cycling and horse-riding. These findings represent the first relationships of testicular cancer with well-defined postnatal risk factors. TESTICULAR CANCER is now the most common neoplasm in men aged 25-34 in England and Wales (Davies, 1981) and follows only non-melanoma skin cancer in Canada (Statistics Canada, 1980). Mortality in young men has been rising during this century in a number of countries (Davies, 1981; Grumet & MacMahon, 1958). Similar increases in incidence have been reported by several cancer registries for the age range 15-30 (Muir & Nectoux, 1978; Schottenfeld et al., 1980; Clemmesen, 1969; Petersen & Lee, 1972). Current estimates of incidence in British Columbia indicate that approximately 1 in 400 males will develop testicular cancer (Cancer Registry, 1975). The majority of studies of the epidemiology of testicular tumours have used routinely collected data to analyse the effects of factors such as social class, marital status, geography, racial group and religious preference. Case-control studies have analysed factors such as cryptorchidism and other prenatal conditions. Where it was examined, these studies have shown that, while differences exist in the age-specific incidence, treatment and prognosis of seminoma compared to other types of testicular cancer, the relationship to known risk factors is similar (Morrison, 1976b; Graham et al., 1977). The present report examines a number of characteristics of childhood and adolescence in a case-control study of all patients treated for seminoma of the testis at a regional treatment centre in the period 1970-77.

  18. Identifying gaps in breast cancer research: Addressing disparities and the roles of the physical and social environment

    E-Print Network [OSTI]

    2007-01-01T23:59:59.000Z

    as part of anti- cancer treatment. Eur J Cancer. 2005, 41(status, and breast cancer treatment and survival. J Natlin the receipt of cancer treatment. J Natl Cancer Inst.

  19. The role of uPAR signaling in lung cancer Background and significance

    E-Print Network [OSTI]

    Gleeson, Joseph G.

    The role of uPAR signaling in lung cancer Background and significance Lung cancer is the leading of lung cancer non-small-cell-lung cancer (about 85% of all lung cancer cases) and small- cell-lung cancer (about 15%) (Herbst et al., 2008). Small cell lung carcinoma (SCLC) is rapidly growing and often

  20. Cold atmospheric plasma in cancer therapy

    SciTech Connect (OSTI)

    Keidar, Michael; Shashurin, Alex; Volotskova, Olga [Mechanical and Aerospace Engineering, George Washington University, Washington DC 20052 (United States)] [Mechanical and Aerospace Engineering, George Washington University, Washington DC 20052 (United States); Ann Stepp, Mary [Medical School, George Washington University, Washington DC 20052 (United States)] [Medical School, George Washington University, Washington DC 20052 (United States); Srinivasan, Priya; Sandler, Anthony [Childrens National Medical Center, Washington DC 20010 (United States)] [Childrens National Medical Center, Washington DC 20010 (United States); Trink, Barry [Head and Neck Cancer Research Division, Department of Otolaryngology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205 (United States)] [Head and Neck Cancer Research Division, Department of Otolaryngology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205 (United States)

    2013-05-15T23:59:59.000Z

    Recent progress in atmospheric plasmas has led to the creation of cold plasmas with ion temperature close to room temperature. This paper outlines recent progress in understanding of cold plasma physics as well as application of cold atmospheric plasma (CAP) in cancer therapy. Varieties of novel plasma diagnostic techniques were developed recently in a quest to understand physics of CAP. It was established that the streamer head charge is about 10{sup 8} electrons, the electrical field in the head vicinity is about 10{sup 7} V/m, and the electron density of the streamer column is about 10{sup 19} m{sup ?3}. Both in-vitro and in-vivo studies of CAP action on cancer were performed. It was shown that the cold plasma application selectively eradicates cancer cells in-vitro without damaging normal cells and significantly reduces tumor size in-vivo. Studies indicate that the mechanism of action of cold plasma on cancer cells is related to generation of reactive oxygen species with possible induction of the apoptosis pathway. It is also shown that the cancer cells are more susceptible to the effects of CAP because a greater percentage of cells are in the S phase of the cell cycle.

  1. Comprehensive genomic characterization of squamous cell lung cancers

    E-Print Network [OSTI]

    Lander, Eric S.

    Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no ...

  2. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print Wednesday, 27 February 2008 00:00 The veil has...

  3. Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer

    E-Print Network [OSTI]

    Ooi, Chia Huey

    Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric cancer (GC) with significant relationships ...

  4. Oestrogen metabolism and action in epithelial ovarian cancer

    E-Print Network [OSTI]

    Ren, Xia

    2011-11-25T23:59:59.000Z

    Ovarian cancer is the most fatal of all gynecological malignancies. Epithelial ovarian cancer (EOC) accounts for about 90% of malignant ovarian tumours and is thought to originate mostly from ovarian surface epithelium ...

  5. Function of the anterior gradient protein family in cancer

    E-Print Network [OSTI]

    Fourtouna, Argyro

    2009-01-01T23:59:59.000Z

    Proteomic technologies verified Anterior Gradient 2, AGR-2, as a protein over-expressed in human cancers, including breast, prostate and oesophagus cancers, with the ability to inhibit the tumour suppressor protein p53. AGR-2 gene is a hormone...

  6. Carbohydrate Intake and Outcomes among Postmenopausal Breast Cancer Survivors /

    E-Print Network [OSTI]

    Emond, Jennifer Ann

    2013-01-01T23:59:59.000Z

    departments, 1992 to 2001. Ann Emerg Med. 2005;46(1):77-81.term breast cancer survivors. Ann Behav Med. 3. Wu AH, Gomezpositive breast cancer cells. Ann Oncol. 2011;22( 1):68-73.

  7. In vitro study of cancer cell extravasation in microfluidic platform

    E-Print Network [OSTI]

    Jeon, Jessie Sungyun

    2014-01-01T23:59:59.000Z

    Cancer metastases arise from the cancer cells that disseminate from the primary tumor, intravasate into the vascular system and eventually transmigrate across the endothelium into to a secondary site through a process of ...

  8. Statistical analysis of Single Nucleotide Polymorphism microarrays in cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    Statistical analysis of Single Nucleotide Polymorphism microarrays in cancer studies Pierre Neuvial Nucleotide Polymorphism (SNP) arrays. We define the copy number states formally, and show how Nucleotide Polymorphism microarrays in cancer studies

  9. Diabetes and breast cancer : the women's healthy eating & living study

    E-Print Network [OSTI]

    Erickson, Kirsten Diann

    2011-01-01T23:59:59.000Z

    and their effects on diabetes risk, randomized controlledQiao Q, Zethelius B, et al: Diabetes, prediabetes and cancerS, Lopez A, et al: Diabetes, obesity and survival in a large

  10. Spiritual Coping and Adjustment in Siblings of Children with Cancer

    E-Print Network [OSTI]

    Kaal, Julia

    2011-11-23T23:59:59.000Z

    Approximately 12 000 US children are diagnosed with some form of cancer every year (Ries et al., 2006)....

  11. WON EXPOSURE AND LUNG CANCER RISK

    E-Print Network [OSTI]

    unknown authors

    As information on indoor air quality accumulated * it became apparent that radon and its progeny are invariably present in indoor environments and that concentrations may reach unacceptably high levels. The lung cancer excess anong miners exposed to radon progeny raised concern that exposure to radon progeny might also cause lung cancer in the general population. This presentation first provides an ovemiew of radon daughter carcinogenesis, and then reviews the recent BEIR IV report. The report described a statistical model * based on analysis of data from four studies of miners, for estimating the lung cancer risk associated with exposure to radon progeny. Tbe analyses showed that the risk of radon exposure declines with time since exposure and with increasing age. The BEIR IV committee concluded that radon progeny and cigarette smoking interact in a multiplicative fashion and that exposure-dose relationships are similar for exposure in homes and in mines.

  12. Targeted therapies hold out the promise of a new era in cancer treatment, but will we fear cancer any the less? The making of a modern disease.

    E-Print Network [OSTI]

    Shapin, Steven

    Targeted therapies hold out the promise of a new era in cancer treatment, but will we fear cancer-marrow sample taken, but she knows about leukemia. It's cancer of the blood. She's terrified, and she may not just a cancer ward but a cancer world. The ward is what the sociologist Erving Goffman once called

  13. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

    E-Print Network [OSTI]

    Ren, Yin

    A comprehensive understanding of the molecular vulnerabilities of every type of cancer will provide a powerful roadmap to guide therapeutic approaches. Efforts such as The Cancer Genome Atlas Project will identify genes ...

  14. Breast Cancer Cells Induce Cancer-Associated Fibroblasts to Secrete Hepatocyte Growth Factor to Enhance Breast Tumorigenesis

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    fetal bovine serum and 1610 5 MDA-MB-468 cells were seededwith human breast cancer MDA-MB-468 cells in a transwellNAFs with breast cancer MDA-MB-468 cells in a transwell

  15. High Prevalence of Lung Cancer in a Surgical Cohort of Lung Cancer Patients A Decade After Smoking Cessation

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    AJ, Samet M: Epidemiology of Lung Cancer. Chest 2003, 123:The accumulated evidence on lung cancer and environmentalMR, Fueger JJ, et al: Lung carcinoma in former smokers.

  16. Discovering Novel Cancer Therapies: A Computational Modeling and Search Approach

    E-Print Network [OSTI]

    Flann, Nicholas

    of new blood vessels (angiogenesis) is an important approach in cancer treatment. However, the complexity-based approach for the discovery of novel potential cancer treatments using a high fidelity simulation in cancer treatment [2]. This paper introduces a computational approach to search for novel intervention

  17. COMPUTER SUPPORT FOR PROTOCOL-BASED TREATMENT OF CANCER1

    E-Print Network [OSTI]

    Sergot, Marek

    COMPUTER SUPPORT FOR PROTOCOL-BASED TREATMENT OF CANCER1 PETER HAMMOND2 AND MAREK SERGOT3 July 1994 Cancer treatment is often carried out within protocol-based clinical trials. An oncology clinic may take of many protocols, the life-threatening nature of cancer and the toxicity of treatment side

  18. An Optimal Control Approach to Cancer Treatment under Immunological Activity

    E-Print Network [OSTI]

    Ledzewicz, Urszula

    An Optimal Control Approach to Cancer Treatment under Immunological Activity Urszula Ledzewicz Mathematical models for cancer treatment that include immunological activity are con- sidered as an optimal. For various growth models on the cancer cells the existence and optimality of singular controls

  19. Optimisation of cancer drug treatments using cell population dynamics

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    Optimisation of cancer drug treatments using cell population dynamics Frederique Billy1 , Jean. The constraints at stake, met everyday in the clinic of cancers, are related mainly to resistance to treatment models used in cancer treatment in the last decades, together with the biological phenomena that can

  20. Controlling the Bone Marrow Dynamics in Cancer Chemotherapy

    E-Print Network [OSTI]

    Ledzewicz, Urszula

    Professor Award 1 #12;find optimal strategies for chemotherapy treatments of the cancer, where Controlling the Bone Marrow Dynamics in Cancer Chemotherapy Urszula Ledzewicz1 and Heinz Sch In the paper a mathematical model for the growth of the bone marrow under cell-cycle specific cancer

  1. QUANTITATIVE SONOGRAPHIC PROSTATE CANCER CHARACTERIZTION A Thesis Presented

    E-Print Network [OSTI]

    Huston, Dryver R.

    QUANTITATIVE SONOGRAPHIC PROSTATE CANCER CHARACTERIZTION A Thesis Presented by Zhi He are at risk for developing prostate cancer, and as a man ages, his risk of developing prostate cancer acquiring the ultrasound data, the specimen is sectioned for histological analysis at 2 mm intervals

  2. Cancer Phylogenetics from Single-Cell Assays Gregory Pennington

    E-Print Network [OSTI]

    Cancer Phylogenetics from Single-Cell Assays Gregory Pennington Stanley Shackney Russell Schwartz the Carnegie Mellon University Berkman Faculty Development Fund. #12;Keywords: computational biology, cancer, FISH, phylogeny #12;Abstract In the field of cancer biology, there is currently great interest

  3. Genetic Susceptibility and Survival: Application to Breast Cancer

    E-Print Network [OSTI]

    West, Mike

    Genetic Susceptibility and Survival: Application to Breast Cancer Edwin S. IVERSEN, JR., Giovanni are known to confer an elevated risk of both breast and ovarian cancers. The effect of carrying such a mutation on survival after developing breast or ovarian cancer is less well understood. We investigate

  4. Putting cancer in focusPathologists key to picking the

    E-Print Network [OSTI]

    Eichman, Brandt F.

    Putting cancer in focusPathologists key to picking the right path to a cure momentum IN THIS ISSUE without cancer. #12;EDITOR Heather Newman DESIGN Diana Duren DIRECTOR OF PUBLICATIONS Wayne Wood ASSOCIATE / Photo Researchers, Inc. EDITORIAL OFFICE Vanderbilt-Ingram Cancer Center 691 Preston Building Nashville

  5. AN ANISOTROPIC DIFFUSION APPROACH FOR EARLY DETECTION OF BREAST CANCER

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    AN ANISOTROPIC DIFFUSION APPROACH FOR EARLY DETECTION OF BREAST CANCER Marius George LINGURARU, Oxford OX2 7BZ, United Kingdom mglin@robots.ox.ac.uk Abstract: The prevalence of breast cancer must provide effective clinical methods to detect cancer and improve life expectancy. Considerable

  6. Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance

    E-Print Network [OSTI]

    Hanson, Floyd B.

    Cancer Treatment Using Multiple Chemotheraputic Agents Subject to Drug Resistance J. J. Westman-7045 USA Abstract A compartment model for the evolution of cancer subject to multiple chemotherapeutic agents is presented. The formulation accounts for the heterogeneous nature of cancer and drug resistance

  7. Skin cancer detection by oblique-incidence diffuse reflectance spectroscopy

    E-Print Network [OSTI]

    Smith, Elizabeth Brooks

    2009-05-15T23:59:59.000Z

    Skin cancer is the most common form of cancer and it is on the rise. If skin cancer is diagnosed early enough, the survival rate is close to 90%. Oblique-incidence diffuse reflectance (OIR) spectroscopy offers a technology that may be used...

  8. [CANCER RESEARCH 61, 59745978, August 15, 2001] Advances in Brief

    E-Print Network [OSTI]

    Jin, Jiashun

    [CANCER RESEARCH 61, 5974­5978, August 15, 2001] Advances in Brief Analysis of Gene Expression Identifies Candidate Markers and Pharmacological Targets in Prostate Cancer John B. Welsh, Lisa M. Sapinoso., H. F. F.] Abstract Detection, treatment, and prediction of outcome for men with prostate cancer

  9. An analysis and hypothesis generation platform for heterogeneous cancer

    E-Print Network [OSTI]

    Reed, Chris

    An analysis and hypothesis generation platform for heterogeneous cancer databases. Philip Roy QUINLAN a,1, Alastair THOMPSON a and Chris REED b a Dundee Cancer Centre, University of Dundee, Ninewells Hospital, Dundee b School of Computing, University of Dundee, Dundee Abstract. The field of cancer research

  10. Cancer Pain Management: A Jordanian Perspective Ibraheem Bashayreh(a)

    E-Print Network [OSTI]

    Cancer Pain Management: A Jordanian Perspective Ibraheem Bashayreh(a) , Davina Porock(b) , Nick of the study: was to evaluate the attitudinal barriers to cancer-pain management among cnacer patients five factors . These factors contribute to ineffective cancer pain management among them and include

  11. Microfabricated Optical Sensor Probe for the Detection of Esophageal Cancer

    E-Print Network [OSTI]

    Chinna Balareddy, Karthik Reddy

    2012-10-19T23:59:59.000Z

    Cancer is a class of diseases in which a group of cells grow uncontrollably, destroy surrounding tissue and eventually spread to other parts of the body, often leading to death. According to the American Cancer Society cancer causes accounts for 13...

  12. Glucose conjugation for the specific targeting and treatment of cancer

    E-Print Network [OSTI]

    Hergenrother, Paul J.

    Glucose conjugation for the specific targeting and treatment of cancer Emilia C. Calvaresia and Paul J. Hergenrother*ab Cancers of diverse origins exhibit marked glucose avidity and high rates has led to an interest in targeting it for cancer therapy. One promising strategy for such targeting

  13. DISCOVERY OF MUTATED SUBNETWORKS ASSOCIATED WITH CLINICAL DATA IN CANCER

    E-Print Network [OSTI]

    Raphael, Ben J.

    DISCOVERY OF MUTATED SUBNETWORKS ASSOCIATED WITH CLINICAL DATA IN CANCER FABIO VANDIN, PATRICK CLAY,pclay,eli,braphael}@cs.brown.edu A major goal of cancer sequencing projects is to identify genetic alterations that determine clinical phenotypes, such as survival time or drug response. Somatic mutations in cancer are typically very diverse

  14. Friday, April 29, 2011 UNM Research Looks at Cancer

    E-Print Network [OSTI]

    Brinker, C. Jeffrey

    Friday, April 29, 2011 UNM Research Looks at Cancer By Olivier Uyttebrouck Copyright © 2011 Albuquerque Journal Journal Staff Writer Chemotherapy can save the lives of cancer patients, but side effects are developing a technique they say can deliver minute amounts of cancer-fighting drugs directly into a diseased

  15. RESEARCH ARTICLE Open Access Survival advantages conferred to colon cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    RESEARCH ARTICLE Open Access Survival advantages conferred to colon cancer cells by E Klinck5 , François A Auger4 and Jacques Huot1* Abstract Background: Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells

  16. Animal Cancer Care and Research Program Summer 2011

    E-Print Network [OSTI]

    Minnesota, University of

    Synergy Animal Cancer Care and Research Program Summer 2011 Michael G. Conzemius, D.V.M., Ph Cancer Care and Research Program 2 · Synergy Summer 2011 COTC016: A pilot study to assess feasibility Clinical Sciences, College of Veterinary Medicine and Masonic Cancer Center T he University of Minnesota

  17. ORAL CANCER IN NEVADA: A PUBLIC HEALTH PERSPECTIVE

    E-Print Network [OSTI]

    Ahmad, Sajjad

    ORAL CANCER IN NEVADA: A PUBLIC HEALTH PERSPECTIVE by Karl Kingsley, PhD Doctor of Philosophy the thesis prepared under our supervision by Karl Kingsley, Ph.D. entitled Oral Cancer in Nevada: A Public May 2010 #12;iii ABSTRACT Oral Cancer in Nevada: A Public Health Perspective by Karl Kingsley, Ph

  18. Cancer Cell Dissecting the Unique Role of the Retinoblastoma

    E-Print Network [OSTI]

    Cancer Cell Article Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during-cycle control. However, cancer-associated mutations are almost exclusively found in RB, implying that RB has for cancer development; hence, the roles and regulation of RB have been intensively studied (reviewed

  19. BIOL10500 The Biology of Cancer Spring 2012

    E-Print Network [OSTI]

    every cell type in the body. This course will investigate how genetic and environmental factors lead to transformation of cells, how cancer cells function, the cellular systems designed to protect normal cells from becoming cancerous, and how the immune system protects against cancer. The course will examine the growth

  20. Estimating Volumes of Simulated Lung Cancer Nodules David E. Gilsinn

    E-Print Network [OSTI]

    Gilsinn, David E.

    Estimating Volumes of Simulated Lung Cancer Nodules David E. Gilsinn Bruce R. Borchardt Amelia Tebbe July 15, 2009 Abstract Lung cancer is a disease of uncontrolled cell growth in tissues of the lung. Computed to- mography (CT) shows promise in detecting lung cancers at earlier, more operable

  1. A Systems Approach to Breast Cancer Carcinogenesis to Therapy

    E-Print Network [OSTI]

    A Systems Approach to Breast Cancer ­ Carcinogenesis to Therapy Speaker: Dr. Joe Gray Director, Center for Spatial Systems Biomedicine Oregon Health & Science University Date: Monday, April 18, 2011 that influence cancer behavior, (b) systems biology approaches to elucidate mechanisms by which cancer

  2. Effect of treatment and diet on body weight after breast cancer diagnosis : the women's healthy eating and living (WHEL) study perspective

    E-Print Network [OSTI]

    Saquib, Abu Taiyab M. N.

    2007-01-01T23:59:59.000Z

    behavioral, cancer, and treatment related variables, thoughtbehavioral, cancer, and treatment related characteristicsweight after breast cancer treatments: evidence from the

  3. Lessons from Tarceva in pancreatic cancer: where are we now, and how should future trials be designed in pancreatic cancer ?

    E-Print Network [OSTI]

    Paris-Sud XI, Universit de

    of this network trying to improve the treatment of pancreatic cancer patients. Recent findings: Tarceva has the mechanisms of cell transformation and also to find appropriate targeted anti- cancer treatments. Among human in the therapeutic armamentarium against cancer raised some hopes in the treatment of patients with advanced

  4. 17/03/2006 Accepted in European Journal of Cancer Prevention Time Trends and Geographic Variations for Thyroid Cancer

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    17/03/2006 Accepted in European Journal of Cancer Prevention 1 Time Trends and Geographic Variations for Thyroid Cancer in New Caledonia, a Very High Incidence Area (1985-1999) Thérèse Truong1 mail: guenel@vjf.inserm.fr Running head: Incidence of thyroid cancer in New Caledonia #12

  5. Identifying Men Diagnosed With Clinically Localized Prostate Cancer Who are at High Risk for Death From Prostate Cancer

    E-Print Network [OSTI]

    Chen, Ming-Hui

    Identifying Men Diagnosed With Clinically Localized Prostate Cancer Who are at High Risk for Death From Prostate Cancer Anthony V. D'Amico,* Ming Hui-Chen, Andrew A. Renshaw, Brenda Sussman, Kimberly A), Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, Department

  6. Lung Cancer . Author manuscript p16INK4A inactivation mechanisms in non-small-cell lung cancer patients

    E-Print Network [OSTI]

    Boyer, Edmond

    Lung Cancer . Author manuscript Page /1 10 p16INK4A inactivation mechanisms in non-small-cell lung occupational risk factor and that asbestos acts synergistically with tobacco smoking to induce lung cancer. Although some somatic gene alterations in lung cancer have been linked to tobacco smoke, few data

  7. Strong Memorial Hospital Cancer Committee Report 2 2011 Strong Memorial Hospital Cancer Registry Report

    E-Print Network [OSTI]

    Goldman, Steven A.

    's two largest cancer research facilities could result in a scientific powerhouse, enhancing faculty patients.This accounts for an accrual rate of 16.9 percent using the 2010 registry data for total number

  8. Blood Vessel Normalization in the Hamster Oral Cancer Model for Experimental Cancer Therapy Studies

    SciTech Connect (OSTI)

    Ana J. Molinari; Romina F. Aromando; Maria E. Itoiz; Marcela A. Garabalino; Andrea Monti Hughes; Elisa M. Heber; Emiliano C. C. Pozzi; David W. Nigg; Veronica A. Trivillin; Amanda E. Schwint

    2012-07-01T23:59:59.000Z

    Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer. Materials and Methods: Tumor-bearing hamsters were treated with thalidomide and were compared with controls. Results: Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h. Conclusion: The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.

  9. Small cell lung cancer and cancer stem cell-like cells

    E-Print Network [OSTI]

    Sarvi, Sana

    2014-07-05T23:59:59.000Z

    Small cell lung cancer (SCLC) is a highly aggressive malignancy with extreme mortality and morbidity. Although initially chemo- and radio-sensitive, almost inevitable recurrence and resistance occurs. SCLC patients often ...

  10. Spontaneous Remission of Cancer: Theories from Healers, Physicians, and Cancer Survivors

    E-Print Network [OSTI]

    Turner, Kelly Ann

    2010-01-01T23:59:59.000Z

    cancer during chemotherapy. Ann Oncol, 20(8), 1445-1446.in people with HIV/AIDS. Ann Behav Med, 24(1), 34- Ishak,biological pathways involved. Ann Oncol, 8(10), 1031-1039.

  11. Mutational heterogeneity in cancer and the search for new cancer genes

    E-Print Network [OSTI]

    Helman, Elena

    Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing of matched ...

  12. Activin inhibits telomerase activity in cancer

    SciTech Connect (OSTI)

    Katik, Indzi; Mackenzie-Kludas, Charley; Nicholls, Craig [Department of Immunology, Monash University, Melbourne (Australia)] [Department of Immunology, Monash University, Melbourne (Australia); Jiang, Fang-Xu [Centre for Diabetes Research, Western Australian Institute for Medical Research and The University of Western Australia, Perth (Australia)] [Centre for Diabetes Research, Western Australian Institute for Medical Research and The University of Western Australia, Perth (Australia); Zhou, Shufeng [School of Health Sciences, RMIT University, Melbourne (Australia)] [School of Health Sciences, RMIT University, Melbourne (Australia); Li, He [Department of Immunology, Monash University, Melbourne (Australia)] [Department of Immunology, Monash University, Melbourne (Australia); Liu, Jun-Ping, E-mail: jun-ping.liu@med.monash.edu.au [Department of Immunology, Monash University, Melbourne (Australia)] [Department of Immunology, Monash University, Melbourne (Australia)

    2009-11-27T23:59:59.000Z

    Activin is a pleiotropic cytokine with broad tissue distributions. Recent studies demonstrate that activin-A inhibits cancer cell proliferation with unknown mechanisms. In this report, we demonstrate that recombinant activin-A induces telomerase inhibition in cancer cells. In breast and cervical cancer cells, activin-A resulted in telomerase activity in a concentration-dependent manner. Significant inhibition was observed at 10 ng/ml of activin-A, with a near complete inhibition at 80 ng/ml. Consistently, activin-A induced repression of the telomerase reverse transcriptase (hTERT) gene, with the hTERT gene to be suppressed by 60-80% within 24 h. In addition, activin-A induced a concomitant increase in Smad3 signaling and decrease of the hTERT gene promoter activity in a concentration-dependent fashion. These data suggest that activin-A triggered telomerase inhibition by down-regulating hTERT gene expression is involved in activin-A-induced inhibition of cancer cell proliferation.

  13. Isotope Cancer Treatment Research at LANL

    ScienceCinema (OSTI)

    Weidner, John; Nortier, Meiring

    2014-06-02T23:59:59.000Z

    Los Alamos National Laboratory has produced medical isotopes for diagnostic and imaging purposes for more than 30 years. Now LANL researchers have branched out into isotope cancer treatment studies. New results show that an accelerator-based approach can produce clinical trial quantities of actinium-225, an isotope that has promise as a way to kill tumors without damaging surrounding healthy cells.

  14. Small RNA combination therapy for lung cancer

    E-Print Network [OSTI]

    Tammela, Tuomas

    MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we show that a new lung-targeting nanoparticle is capable of delivering ...

  15. Hypoxia activated cell signaling receptors in cancer

    E-Print Network [OSTI]

    Lester, Robin D.

    2008-01-01T23:59:59.000Z

    Cancer Res. 61:7992-8. Graeber, T.G. , C. Osmanian, T.solid tumours. 379:88-91. Graeber, T.G. , J.F. Peterson, M.by accumulation of p53 (Graeber et al. , 1994), has been the

  16. Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth

    E-Print Network [OSTI]

    of the disease. Thus, drugs that selectively target cancer stem cells offer great promise for cancer treatment and chemotherapeutic drugs to improve treatment of patients with breast (and possibly other) cancers. [Cancer Res 2009;69(19):750711] Introduction Chemotherapeutic treatments for cancer can effectively reduce tumor mass, but the disease often

  17. Get Online Support, Feel Better--Sentiment Analysis and Dynamics in an Online Cancer

    E-Print Network [OSTI]

    ] from cancer and cancer treatments. Each year, many people turn to the Internet to satisfy their health offers a way to share experiences about their cancer and cancer treatment, seek solutions to daily livingGet Online Support, Feel Better--Sentiment Analysis and Dynamics in an Online Cancer Survivor

  18. Get Online Support, Feel Better--Sentiment Analysis and Dynamics in an Online Cancer

    E-Print Network [OSTI]

    Giles, C. Lee

    ] from cancer and cancer treatments. Each year, many people turn to the Internet to satisfy their health to share experiences about their cancer and cancer treatment, seek solutions to daily living issuesGet Online Support, Feel Better--Sentiment Analysis and Dynamics in an Online Cancer Survivor

  19. Changing the Face of Cancer through investments in research, education, outreach and care

    E-Print Network [OSTI]

    Chapman, Michael S.

    this progress. Gifts: Advance the studies of new cancer treatments Recruit and keep talented researchersChanging the Face of Cancer through investments in research, education, outreach and care Giving Guide #12;OHSU Knight Cancer Institute We Will End Cancer As We Know It The OHSU Knight Cancer Institute

  20. Its Not If I Get Cancer, Its When I Get Cancer: Exploring Previvors Management of Uncertainty for Hereditary Cancer in Clinical Encounters

    E-Print Network [OSTI]

    Dean, Marleah Lynn

    2014-07-10T23:59:59.000Z

    decisions affect their subsequent sense of uncertainty. A previvor is an individual who is highly predisposed to breast and ovarian cancer due to a genetic mutation called BRCA1/2. Previvors have a 44 to 87 percent risk of developing cancer during...

  1. Compositions and methods for cancer treatment using targeted carbon nanotubes

    DOE Patents [OSTI]

    Harrison, Jr., Roger G; Resasco, Daniel E; Neves, Luis Filipe Ferreira

    2013-08-27T23:59:59.000Z

    The present invention is a method for detecting and destroying cancer tumors. The method is based on the concept of associating a linking protein or linking peptide such as, but not limited to, annexin V or other annexins to carbon nanotubes such as single-walled carbon nanotubes (SWNTs) to form a protein-CNT complex. Said linking protein or peptide can selectively bind to cancerous cells, especially tumor vasculature endothelial cells, rather than to healthy ones by binding to cancer-specific external receptors such as anionic phospholipids including phosphatidylserine expressed on the outer surfaces of cancer cells only. Irradiation of bound CNTs with one or more specific electromagnetic wavelengths is then used to detect and destroy those cells to which the CNTs are bound via the linking protein or peptide thereby destroying the tumor or cancer cells and preferably an immunostimulant is provided to the patient to enhance the immune response against antigens released from the tumor or cancer cells.

  2. Genome Science and Personalized Cancer Treatment (LBNL Summer Lecture Series)

    SciTech Connect (OSTI)

    Gray, Joe

    2009-08-04T23:59:59.000Z

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks particularly with regard to breast cancer.

  3. Genome Science and Personalized Cancer Treatment (LBNL Summer Lecture Series)

    ScienceCinema (OSTI)

    Gray, Joe

    2011-04-28T23:59:59.000Z

    Summer Lecture Series 2009: Results from the Human Genome Project are enabling scientists to understand how individual cancers form and progress. This information, when combined with newly developed drugs, can optimize the treatment of individual cancers. Joe Gray, director of Berkeley Labs Life Sciences Division and Associate Laboratory Director for Life and Environmental Sciences, will focus on this approach, its promise, and its current roadblocks ? particularly with regard to breast cancer.

  4. Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    disease in non-small cell lung cancer. Semin ThoracW, Khuri FR: The care of the lung cancer patient in the 21stJablons DM: Wnt signaling in lung cancer. Cancer Lett 2005,

  5. For Immediate Release --Wednesday, March 20, 2013 Treating male and female cancer patients with radiation

    E-Print Network [OSTI]

    Seldin, Jonathan P.

    ? gender differences in cancer treatment rarely explored consequences of radiation with radiation treatment of cancer cells and the difference between female and male or female-specific treatments that improve the quality of life for all cancer

  6. Functional census of mutation sequence spaces: The example of p53 cancer rescue mutants

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    aid the search for cancer treatments from p53 mutant rescue.26], [27], [28]. Novel Cancer Treatments and p53 FunctionalCentral to the goal of cancer treatment by p53 functional

  7. Diffuse optical spectroscopic imaging correlates with final pathological response in breast cancer neoadjuvant chemotherapy.

    E-Print Network [OSTI]

    Cerussi, Albert E; Tanamai, Vaya W; Hsiang, David; Butler, John; Mehta, Rita S; Tromberg, Bruce J

    2011-01-01T23:59:59.000Z

    therapeutic endpoints for cancer treatments are 510 yearto endocrine treatment in breast cancer. J. Clin. Oncol. 24,E. 2006 Neoadjuvant treatment for early-stage breast cancer:

  8. Development of alternating amphiphilic copolymers for targeted delivery applications in cancer

    E-Print Network [OSTI]

    Brower, Kevin P. (Kevin Peter)

    2011-01-01T23:59:59.000Z

    According to the American Cancer Society, approximately 1,479,000 new cases of cancer were expected to be diagnosed, while 562,340 Americans were expected to die from cancer in 2009 alone. Even though advances in early ...

  9. Potential for Cardiovascular Exercise Dosing to Improve Cardiorespiratory Fitness in Breast Cancer Survivors

    E-Print Network [OSTI]

    Burnett, Dave

    2013-05-31T23:59:59.000Z

    With an increase in early detection and curative treatment for breast cancer, there is a growing number of breast cancer survivors. Cancer survivors are at greater risk than their age matched peers for long-term health ...

  10. Novel Approaches to Breast Cancer Therapy: Evaluation of Next Generation Dendrimers for Drug Delivery

    E-Print Network [OSTI]

    Snow, Merideth

    2010-07-14T23:59:59.000Z

    Breast cancer is the second leading cause of cancer deaths in women with approximately 40,000 patient deaths each year. Theranostics is an emerging area of cancer research in which chemically synthesized molecules are used to simultaneously deliver...

  11. McGill Cancer NutritionRehabilitation Program Annual Report 2010 AAPPPPEENNDDIIXX II

    E-Print Network [OSTI]

    Barthelat, Francois

    McGill Cancer NutritionRehabilitation Program Annual Report 2010 Appendix-1 AAPPPPEENNDDIIXX II CCLLIINNIICCAALL AACCTTIIVVIITTYY MCGILL CANCER NUTRITIONREHABILITATION PROGRAM changes in team structure in 2010. ** No Social Worker on staff in 2010. #12;McGill Cancer Nutrition

  12. McGill Cancer NutritionRehabilitation Program Annual Report 2009 AAPPPPEENNDDIIXX II

    E-Print Network [OSTI]

    Barthelat, Francois

    McGill Cancer NutritionRehabilitation Program Annual Report 2009 AAPPPPEENNDDIIXX II CCLLIINNIICCAALL AACCTTIIVVIITTYY McGill Cancer NutritionRehabilitation Program Statistics for January;McGill Cancer NutritionRehabilitation Program Annual Report 2009 AAPPPPEENNDDIIXX IIII

  13. Cancer survivors and survivorship care: Provider expectations, post-treatment health services, and patient reported outcomes

    E-Print Network [OSTI]

    Hahn, Erin Elizabeth

    2013-01-01T23:59:59.000Z

    2011) Long Term Effects and Cancer Survivorship in the OlderGanz (Eds. ), Management of Cancer for the Older Patient (the Quality of Care for Cancer Survivors. Psycho-Oncology (

  14. advanced rectal cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    advanced rectal cancer (LARC) and the impact of partial volume effects correction (PVC PVC. Their predictive value was investigated using Mann-Whitney-U tests and ROC...

  15. ascending colon cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: , and Genetic Discoveries in Pancreatic, Liver, and Biliary Cancers Program specialists are pioneering new and individualized care for patients with...

  16. azoxymethane colon cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Websites Summary: , and Genetic Discoveries in Pancreatic, Liver, and Biliary Cancers Program specialists are pioneering new and individualized care for patients with...

  17. adequate cervical cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and fee-for-service-based Family Health Groups receive bonuses for delivering preventive care, including cervical cancer screening, while those practicing (more)...

  18. advanced cervical cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and fee-for-service-based Family Health Groups receive bonuses for delivering preventive care, including cervical cancer screening, while those practicing (more)...

  19. advanced cervical cancers: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and fee-for-service-based Family Health Groups receive bonuses for delivering preventive care, including cervical cancer screening, while those practicing (more)...

  20. african cervical cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    and fee-for-service-based Family Health Groups receive bonuses for delivering preventive care, including cervical cancer screening, while those practicing (more)...

  1. Yeast-based vaccine approaches to cancer immunotherapy

    E-Print Network [OSTI]

    Howland, Shanshan W

    2008-01-01T23:59:59.000Z

    Saccharomyces cerevisiae stimulates dendritic cells and represents a promising candidate for cancer immunotherapy development. Effective cross-presentation of antigen delivered to dendritic cells is necessary for successful ...

  2. School Response to Families with Children with Cancer

    E-Print Network [OSTI]

    Nielsen, Shelley Lynn

    2010-01-01T23:59:59.000Z

    Sports x Relationship with School None Good Very Good x x xissues in childhood cancer. School Psychology Review, 28(2),quality of life, and school experiences. Exceptional

  3. Molecular cytogenetic characterization of a human thyroid cancer cell line

    E-Print Network [OSTI]

    2006-01-01T23:59:59.000Z

    gland during the Chernobyl catastrophe. Environmental Healthradiation as a result of the Chernobyl disaster. Cancer 76,1986 nuclear accident in Chernobyl, Ukraine. In the twelve

  4. Identification of cancer protein biomarkers using proteomic techniques

    DOE Patents [OSTI]

    Mor, Gil G. (Cheshire, CT); Ward, David C. (Las Vegas, NV); Bray-Ward, Patricia (Las Vegas, NV)

    2010-02-23T23:59:59.000Z

    The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.

  5. Jefferson Lab Medical Imager Spots Breast Cancer | Jefferson...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Eric Rosen, Duke University Medical Center Jefferson Lab Medical Imager Spots Breast Cancer March 3, 2005 Newport News, VA - A study published in the February issue of the...

  6. Protocadherin-7 induces bone metastasis of breast cancer

    SciTech Connect (OSTI)

    Li, Ai-Min [Department of Orthopedics, The 5th Central Hospital of Tianjin, Tianjin (China)] [Department of Orthopedics, The 5th Central Hospital of Tianjin, Tianjin (China); Tian, Ai-Xian [Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)] [Department of Biochemistry and Molecular Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Zhang, Rui-Xue [Department of Clinical Laboratory Diagnosis, Tianjin Medical University, Tianjin (China)] [Department of Clinical Laboratory Diagnosis, Tianjin Medical University, Tianjin (China); Ge, Jie [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Sun, Xuan [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)] [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Cao, Xu-Chen, E-mail: caoxuch@126.com [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China) [Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China); Key Laboratory of Breast Cancer Prevention and Treatment of the Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, Tianjin (China)

    2013-07-05T23:59:59.000Z

    Highlights: PCDH7 is overexpression in high bone metastatic MDA-MB-231 cells. PCDH7 is up-regulation in bone metastatic breast cancer tissues. Suppression of PCDH7 inhibits cell proliferation, migration, and invasion in vitro. PCDH7 induces breast cancer bone metastasis in vivo. -- Abstract: Breast cancer had a propensity to metastasize to bone, resulting in serious skeletal complications associated with poor outcome. Previous study showed that Protocadherin-7 (PCDH7) play an important role in brain metastatic breast cancer, however, the role of PCDH7 in bone metastatic breast cancer has never been explored. In the present study, we found that PCDH7 expression was up-regulation in bone metastatic breast cancer tissues by real-time PCR and immunohistochemistry assays. Furthermore, suppression of PCDH7 inhibits breast cancer cell proliferation, migration, and invasion in vitro by MTT, scratch, and transwell assays. Most importantly, overexpression of PCDH7 promotes breast cancer cell proliferation and invasion in vitro, and formation of bone metastasis in vivo. These data provide an important insight into the role of PCDH7 in bone metastasis of breast cancer.

  7. Insight into Alzheimer's, cancer, anemia gleaned from ribosome...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Insights from ribosome research Insight into Alzheimer's, cancer, anemia gleaned from ribosome research Groundbreaking study of the human ribosome reveals tiny molecular machine is...

  8. Three-Dimensional Thermal Tomography Advances Cancer Treatment...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Three-Dimensional Thermal Tomography Advances Cancer Treatment Technology available for licensing: A 3D technique to detect early skin changes due to radiation treatment in breast...

  9. DOE/EA-0965 ENVIRONMENTAL ASSESSMENT CANCER RESEARCH CENTER

    Broader source: Energy.gov (indexed) [DOE]

    65 ENVIRONMENTAL ASSESSMENT CANCER RESEARCH CENTER INDIANA UNIVERSITY SCHOOL OF MEDICINE PREPARED BY U.S. DEPARTMENT O F ENERGY, CHICAGO FIELD OFFICE PROGRAMS AND FACILITIES...

  10. attenuates bone cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    human bone were studied via the small scale mechanical loading test. Failure analysis was conducted... Jang, Eunhwa 2012-10-19 19 ORIGINAL ARTICLE JBMR Cancer Treatment...

  11. Nanotechnology in Head and Neck Cancer: The Race Is On

    E-Print Network [OSTI]

    El-Sayed, Ivan H.

    2010-01-01T23:59:59.000Z

    10.1007/s11912-010-0087-2 Nanotechnology in Head and Neckthe applications of nanotechnology in head and neck cancer,plasmonic gold nanotechnology. Keywords Nanotechnology .

  12. From Bombs to Breast Cancer Imaging: Los Alamos National Laboratory

    SciTech Connect (OSTI)

    Martineau, Rebecca M [Los Alamos National Laboratory

    2012-07-26T23:59:59.000Z

    In the United States, one in eight women will be affected by breast cancer. According to the American Cancer Society, breast cancer is the most commonly diagnosed - as well as the second most fatal - cancer in American women. It is estimated that there will be nearly 200,000 diagnoses of breast cancer this year; more than 40,000 of these will be fatal. Although advances in medical technologies have greatly increased the odds of surviving the disease, the increase in screenings has not resulted in a significant reduction in the breast cancer mortality rate. Moreover, recent studies have even suggested that an increase in these methods might, in itself, cause cancer. A new tool for early detection and diagnosis of breast cancer, supported by an award from the Breast Cancer Research Program (BCRP) of the Congressionally Directed Medical Research Programs of Department of Defense, could give women a new advantage in the fight against breast cancer. This LANL-led project will integrate ultrasound tomography (UST) with recent discoveries in the field of cell and tissue biomechanics to improve breast cancer detection and characterization. UST uses ultrasound waves instead of X-rays to identify and characterize breast tumors. This technology reveals small mechanical-property changes within the breast. These changes are often the earliest signs of breast cancer. Additionally, UST is effective for women with dense breast tissue, who have a higher risk of developing breast cancer. Because the technology does not use radiation, UST can also be used as frequently as needed for women with a high risk of developing breast cancer. In contrast, mammography, the only routine breast-cancer screening tool currently available, is not effective for women with dense breast tissue and may come with unwanted side-effects caused by ionizing radiation. UST has great potential to become an alternative breast-cancer screening tool because of UST's advantages and benefits over mammography. Currently, there is fierce debate surrounding the age at which breast cancer screening should begin, and once begun, how often it should occur. The American Cancer Society recommends yearly mammograms starting at age 40. On the other hand, the U.S. Preventive Services Task Force recommends against routine so early. Rather, the Task Force recommends biennial mammography screening for women aged 50 to 74 years. The ten-year discrepancy in the onset of screening results from recent data suggesting that the frequent use of X-ray radiation during screenings could potentially increase the likelihood of developing cancer. This danger is increased by the low sensitivity and accuracy of mammograms, which sometimes require multiple screenings to yield results. Furthermore, mammograms are often not only inaccurate, but average appalling misdiagnoses rates: about 80% false positives and 15% false negatives. These misdiagnoses lead to unwarranted biopsies at an estimated health care cost of $2 billion per year, while at the same time, resulting in excessive cases of undetected cancer. As such, the National Cancer Institute recommends more studies on the advantages of types and frequency of screenings, as well as alternative screening options. The UST technology developed at LANL could be an alternative option to greatly improve the specificity and sensitivity of breast cancer screening without using ionizing radiation. LANL is developing high-resolution ultrasound tomography algorithms and a clinical ultrasound tomography scanner to conduct patient studies at the UNM Hospital. During UST scanning, the patient lies face-down while her breast, immersed in a tank of warm water, is scanned by phased-transducer arrays. UST uses recorded ultrasound signals to reconstruct a high-resolution three-dimensional image of the breast, showing the spatial distribution of mechanical properties within the breast. Breast cancers are detected by higher values of mechanical properties compared to surrounding tissues. Thus, high-resolution breast images obtained using LANL's novel UST algorithms ha

  13. SU-E-J-95: Predicting Treatment Outcomes for Prostate Cancer: Irradiation Responses of Prostate Cancer Stem Cells

    SciTech Connect (OSTI)

    Wang, K [University of Miami, Miami, FL (United States)

    2014-06-01T23:59:59.000Z

    Purpose: Most prostate cancers are slow-growing diseases but normally require much higher doses (80Gy) with conventional fractionation radiotherapy, comparing to other more aggressive cancers. This study is to disclose the radiobiological basis of this discrepancy by proposing the concept of prostate cancer stem cells (CSCs) and examining their specific irradiation responses. Methods: There are overwhelming evidences that CSC may keep their stemness, e.g. the competency of cell differentiation, in hypoxic microenvironments and hence become radiation resistive, though the probability is tiny for aggressiveness cancers. Tumor hypoxia used to be considered as an independent reason for poor treatment outcomes, and recent evidences showed that even prostate cancers were also hypoxic though they are very slow-growing. In addition, to achieve comparable outcomes to other much more aggressive cancers, much higher doses (rather than lower doses) are always needed for prostate cancers, regardless of its non-aggressiveness. All these abnormal facts can only be possibly interpreted by the irradiation responses characteristics of prostate CSCs. Results: Both normal cancer cells (NCCs) and CSCs exiting in tumors, in which NCCs are mainly for symptoms whereas killing all CSCs achieves disease-free. Since prostate cancers are slow-growing, the hypoxia in prostate cancers cannot possibly from NCCs, thus it is caused by hypoxic CSCs. However, single hypoxic cell cannot be imaged due to limitation of imaging techniques, unless a large group of hypoxic cells exist together, thus most of CSCs in prostate cancers are virtually hypoxic, i.e. not in working mode because CSCs in proliferating mode have to be normoxic, and this explains why prostate cancers are unaggressive. Conclusion: The fractional dose in conventional radiotherapy (?2Gy) could only kill NCCs and CSCs in proliferating modes, whereas most CSCs survived fractional treatments since they were hypoxic, thus to eliminate all CSCs and achieve disease-free, much more fractionations are needed.

  14. antibody-targeted radiation cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    therapy treatment for cancer Venue: Science Gallery Trinity College Therapist, Zagreb, Croatia 17.00-17.30: Radiation Therapy for Prostate Cancer: Professional and Patient...

  15. E-Print Network 3.0 - assessment guidelines cancer Sample Search...

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    the NYS Cancer Services Program Summary: cancer and should be referred to an appropriate health care provider for a full risk assessment which can... for risk assessment (http:...

  16. age-adjusted cancer mortality: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Cancer Mortality Kenneth G. Brown; Barbara D. Beck; Claudia Hopenhayn-Rich; Mary Lou Biggs; Allan H. Smith Biology and Medicine Websites Summary: Arsenic and Bladder Cancer...

  17. Lung Cancer (2005) 47, 41--47 Improving the specificity of fluorescence

    E-Print Network [OSTI]

    Duin, Robert P.W.

    2005-01-01T23:59:59.000Z

    Lung Cancer (2005) 47, 41--47 Improving the specificity of fluorescence bronchoscopy spectroscopy; Lung cancer; Bronchoscopy Summary Detection of malignancies of the bronchial tree in an early

  18. Dana-Farber Cancer Institute About Dana-Farber Cancer Institute

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    to patients from across the country and around the world. #12;About the Jimmy Fund The Jimmy Fund raises vital, the generosity of millions of people has helped the Jimmy Fund save countless lives and reduce the burden of cancer. The Jimmy Fund has: ·raised more than $875 million since 1948, including $67 million in 2012

  19. New Directions and Approached to Cancer Treatment: Dr Mike Partridge

    E-Print Network [OSTI]

    New Directions and Approached to Cancer Treatment: Imaging Dr Mike Partridge STFC Workshop, Birmingham, 28th January 2010 Joint Department of Physics The Institute of Cancer Research / The Royal to treatment to determine anatomical targets and organs-at-risk. A clear next step is to use biological

  20. An ecological study of lymphatic cancer mortality in Texas

    E-Print Network [OSTI]

    Noel, Lawrence Brooks

    1999-01-01T23:59:59.000Z

    and histiocytic tissue, multiple myeloma and immunoproliferative neoplasms, and leukemia (ICD codes 200-208). An ecological study was conducted of lymphatic cancer deaths from 1986-1994 for the 194 counties in Texas. Death rates of these cancers were correlated...

  1. The use of polarized light for skin cancer detecton

    E-Print Network [OSTI]

    DeLaughter, Aimee Hill

    2002-01-01T23:59:59.000Z

    and subsequent biopsy of suspicious lesions. Many cancerous lesions are missed and many benign lesions are biopsied using these techniques. This process is painful and expensive. The proposed research is driven by the need for a non-invasive skin cancer...

  2. The Economic Impact of Cancer in West Virginia

    E-Print Network [OSTI]

    Mohaghegh, Shahab

    The Economic Impact of Cancer in West Virginia January 2013 A report prepared for the American Virginia University #12;The Economic Impact of Cancer in West Virginia A Report Prepared for the American West Virginia University 150 Clay St. Morgantown, WV 26501 (304) 293-7831 bebureau@mail.wvu.edu Tami

  3. Page 3 New Approaches in Clinical Trials for Gynecologic Cancers

    E-Print Network [OSTI]

    Liu, Xiaole Shirley

    Oncology, and MichaelG.Muto,MD,werethefirstinNewEnglandtoperform robot-assisted radical hysterectomy cancers are offering new treatment options for patients. Page 4 Patient Outcome Studies Support Robotic Approaches for Gynecologic Cancers Comparing outcomes of patients undergoing robotic versus traditional open

  4. Human brain cancer studied by resonance Raman spectroscopy

    E-Print Network [OSTI]

    Sun, Yi

    Human brain cancer studied by resonance Raman spectroscopy Yan Zhou Cheng-Hui Liu Yi Sun Yang Pu://biomedicaloptics.spiedigitallibrary.org/ on 11/16/2012 Terms of Use: http://spiedl.org/terms #12;Human brain cancer studied by resonance Raman of human brain tissues are examined using a confocal micro-Raman system with 532-nm excitation in vitro

  5. SysBioMed Canary Islands Cancer Research

    E-Print Network [OSTI]

    Timmer, Jens

    SysBioMed Canary Islands Cancer Research Institute Winter School on Systems Biology for Medical Applications 27th February ­ 2nd March 2007 Puerto de la Cruz, Tenerife (Canary Islands) Supported by the European Commission (FP6 projects COSBICS and SysBioMed) and the Canary Islands Institute for Cancer

  6. Quantum Dot-Aptamer Conjugates for Synchronous Cancer Imaging, Therapy,

    E-Print Network [OSTI]

    Zhang, Liangfang

    a novel quantum dot (QD)-aptamer(Apt)-doxorubicin (Dox) conjugate [QD-Apt(Dox)] as a targeted cancer of prostate cancer cells that express the PSMA protein. The intercalation of Dox, a widely used antineoplastic in a targeted QD-Apt(Dox) conjugate with reversible self- quenching properties based on a Bi-FRET mechanism

  7. Method for restoration of normal phenotype in cancer cells

    DOE Patents [OSTI]

    Bissell, Mina J. (Berkeley, CA); Weaver, Valerie M. (Oakland, CA)

    2000-01-01T23:59:59.000Z

    A method for reversing expression of malignant phenotype in cancer cells is described. The method comprises applying .beta..sub.1 integrin function-blocking antibody to the cells. The method can be used to assess the progress of cancer therapy. Human breast epithelial cells were shown to be particularly responsive.

  8. New synthetic derivatives of triterpenoids in the treatment of cancer

    E-Print Network [OSTI]

    Papineni, Sabitha

    2009-05-15T23:59:59.000Z

    of these compounds as selective peroxisome proliferator-activated receptor ? (PPAR?) agonists and as cytotoxic anticancer agents has been investigated in colon, prostate and pancreatic cancer cells. In colon cancer cells ?-CDODA-Me arrested the growth at G2/M...

  9. Method for detecting the presence of prostate cancer

    DOE Patents [OSTI]

    Karin, Michael; Luo, Jun-Li; Tan, Wei

    2010-04-13T23:59:59.000Z

    The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-.alpha. (IKK.alpha.) and the IKK.alpha.-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.

  10. Berkeley Lab Scientist Co-Leads Breast Cancer Dream Team

    ScienceCinema (OSTI)

    Gray, Joe

    2013-05-29T23:59:59.000Z

    An $16.5 million, three-year grant to develop new and more effective therapies to fight breast cancer was awarded today to a multi-institutional Dream Team of scientists and clinicians that is co-led by Joe Gray, a renowned cancer researcher with the U.S. Department of Energys Lawrence Berkeley National Laboratory. http://newscenter.lbl.gov/

  11. Transcriptional Targeting for Ovarian Cancer Gene Therapy E. Casado,*,

    E-Print Network [OSTI]

    Hemminki, Akseli

    ; gene therapy. INTRODUCTION Ovarian cancer afflicts more than 25,000 women annually in the United States Paz, Madrid, Spain Received November 10, 2000 Ovarian carcinoma is a leading cause of cancer death in women. Though advances in conventional therapies have been achieved, long-term survival rates for most

  12. Gene expression profiling identifies clinically relevant subtypes of prostate cancer

    E-Print Network [OSTI]

    Botstein, David

    and are highest in Western countries (2). In the United States, it is the most frequently diagnosed and the second leading cause of cancer death in men (3). Despite these high death rates, prostate cancer is oftenDepartment of Urology, Louisiana State University Health Sciences Center, New Orleans, LA 70112; gSection of Urology

  13. New synthetic derivatives of triterpenoids in the treatment of cancer

    E-Print Network [OSTI]

    Papineni, Sabitha

    2009-05-15T23:59:59.000Z

    of these compounds as selective peroxisome proliferator-activated receptor ? (PPAR?) agonists and as cytotoxic anticancer agents has been investigated in colon, prostate and pancreatic cancer cells. In colon cancer cells ?-CDODA-Me arrested the growth at G2/M...

  14. Diet, nutrients, phytochemicals, and cancer metastasis suppressor genes

    E-Print Network [OSTI]

    Collins, Gary S.

    studied are the ways that major components of the diet such as protein, fat, and lifestyle issues impactDiet, nutrients, phytochemicals, and cancer metastasis suppressor genes Gary G. Meadows # Springer and mortality of cancer patients is metastasis. There exists a relative lack of specific therapeutic approaches

  15. Investigating the initiation and progression of small cell lung cancer

    E-Print Network [OSTI]

    Brauneis, Alison Dooley

    2011-01-01T23:59:59.000Z

    Small cell lung cancer (SCLC) comprises 18% of all lung cancer cases and is an aggressive disease with a five-year survival rate of less than 5%, mainly due to the advanced nature of the disease at the time of diagnosis. ...

  16. Statistical analysis of end-points in cancer clinical trials

    E-Print Network [OSTI]

    Campbell, Ian

    the treatment. 'Quality of life' cannot be defined precisely, and the term is used to cover three types of approach. Firstly, the control of symptoms due to a cancer can be assessed, for example control of cough and chest pain from a lung cancer can be measured...

  17. advanced stomach cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    advanced stomach cancer First Page Previous Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 1 Stomach cancer...67 Chapter 07...

  18. Recent Progress in Ultra-Wideband Microwave Breast Cancer Detection

    E-Print Network [OSTI]

    Coates, Mark

    were diagnosed in the United States and Canada with as many as 45,000 cases leading to death. For women, breast cancer mortality rates are higher than for any other cancer, with the exception of lung as early as possible. This will not only reduce mortality and incidence rates, but also significantly ease

  19. Lung Cancer and Arsenic Concentrations in Drinking Water in Chile

    E-Print Network [OSTI]

    California at Berkeley, University of

    Lung Cancer and Arsenic Concentrations in Drinking Water in Chile Catterina Ferreccio,1,2 Claudia- trations have since been reduced to 40 g/liter. We investi- gated the relation between lung cancer and arsenic in drinking water in northern Chile in a case-control study involving patients diagnosed with lung

  20. Laser research shows promise for cancer treatment

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of Science (SC)Integrated Codes |Is Your Home asLCLSLaboratoryRowlandRevolutionizingLaserLaserCancer

  1. According to the American Cancer Society, one-third of all cancer deaths each year in the United States

    E-Print Network [OSTI]

    Grishok, Alla

    body weight, you must balance the amount of energy you put into your body­ the food you eatAccording to the American Cancer Society, one-third of all cancer deaths each year in the United States are linked to the amount of food you eat, your body weight, and how much exercise you get. Another

  2. Int J Cancer. Author manuscript Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has

    E-Print Network [OSTI]

    Paris-Sud XI, Université de

    peptidimer-c, inhibited colony formation in HER2 over-expressing SKBr3 cancer cells. Combined treatment ; Apoptosis ; drug effects ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Synergism ; Female cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel Gril

  3. Milk Fermented by Propionibacterium freudenreichii Induces Apoptosis of HGT-1 Human Gastric Cancer Cells

    E-Print Network [OSTI]

    Brest, Universit de

    and/or as a food supplement to potentiate cancer therapeutic treatments. Citation: Cousin FJ, JouanMilk Fermented by Propionibacterium freudenreichii Induces Apoptosis of HGT-1 Human Gastric Cancer cancer is one of the most common cancers in the world. The ``economically developed countries'' life

  4. Facts to Help Patients Make an Informed Decision TARGETING CANCER CARE

    E-Print Network [OSTI]

    Kaski, Samuel

    cancer through studies called clinical trials. Today's lung cancer radiation therapy treatments provide treatments or medications to help. Everyone responds differently to the stress of cancerFacts to Help Patients Make an Informed Decision TARGETING CANCER CARE ASTRO 2012 Printed

  5. Cancer Reporting Rule R384-100 R384. Health, Community Health Services, Chronic Disease.

    E-Print Network [OSTI]

    Tipple, Brett

    Cancer Reporting Rule R384-100 R384. Health, Community Health Services, Chronic Disease. R384-100. Cancer Reporting Rule R384-100-1. Purpose Statement (1) The Cancer Reporting Rule is adopted under authority of sections 26-1-30 and 26-5-3. (2) Cancers Constitute a leading cause of morbidity and mortality

  6. Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and

    E-Print Network [OSTI]

    Rosenberg, Michael S.

    Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and geographic We have previously shown that geographic differences in cancer mortalities in Europe are related of 45 male and 47 female cancers. Differences in cancer incidences are correlated moder- ately, first

  7. RESEARCH Open Access Analysis of primary risk factors for oral cancer

    E-Print Network [OSTI]

    Ahmad, Sajjad

    RESEARCH Open Access Analysis of primary risk factors for oral cancer from select US states , Michelle Chino3 , Karl Kingsley1* Abstract Objectives: To examine the primary risk factor for oral cancer in oral cancer incidence and mortality. Methods: Population-based data on oral cancer morbidity

  8. Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 19952007 (the

    E-Print Network [OSTI]

    Maizels, Rick

    1 Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995­2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data M P Coleman Background Cancer survival is a key measure of the effectiveness of health-care systems. Persistent regional

  9. Cancer, Palliative and End of Life Care ResearchProjects2012

    E-Print Network [OSTI]

    Anderson, Jim

    Cancer, Palliative and End of Life Care ResearchProjects2012 #12;2 5 4 Cancer, Palliative and End and students working together to transform care and improve outcomes for individuals affected by cancer, other the right questions to generate theory, influence policy and change practice. Cancer survivorship

  10. AACR Cancer Progress Report 2012 Making Research Count for Patients: A New Day

    E-Print Network [OSTI]

    Sherman, S. Murray

    AACR Cancer Progress Report 2012 Making Research Count for Patients: A New Day www.cancerprogressreport.org · www.aacr.org #12;AACR Cancer Progress Report 2012 Making Research Count for Patients: A New Day www.cancerprogressreport.org · www.aacr.org Also published as: American Association for Cancer Research. AACR cancer progress report

  11. Skin Cancer: A Young Person's Disease By Lauren Duffy (B.S. Communication, Journalism '14)

    E-Print Network [OSTI]

    Massachusetts at Amherst, University of

    Skin Cancer: A Young Person's Disease By Lauren Duffy (B.S. Communication, Journalism '14 is that this behavior is extremely unhealthy and risky for their bodies, specifically their skin. Skin cancer is the most common form of cancer found in young adults and second most common cancer found in adolescents

  12. Cancer Therapy: Preclinical Modulating Endogenous NQO1 Levels Identifies Key Regulatory

    E-Print Network [OSTI]

    Gao, Jinming

    Pancreatic cancer is the fourth leading cause of cancer- related death in the United States. (1). Current cancer is the fourth leading cause of cancer-related deaths, in which the 5-year survival rate is less. Results: b-Lapmediated cell death required $90 enzymatic units of NQO1. Essential downstream mediators

  13. TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk factors

    E-Print Network [OSTI]

    TP53 gene mutations of lung cancer patients in upper northern Thailand and environmental risk mutations are observed in about 40e70% of lung cancer tissues, and the hot spot codon mu- tations factors that influence TP53 gene mutation in lung cancer patients residing areas with high lung cancer

  14. A filter-based feature selection approach for identifying potential biomarkers for lung cancer

    E-Print Network [OSTI]

    Lee, In-Hee; Lushington, Gerald H.; Visvanathan, Mahesh

    2011-03-21T23:59:59.000Z

    Background: Lung cancer is the leading cause of death from cancer in the world and its treatment is dependant on the type and stage of cancer detected in the patient. Molecular biomarkers that can characterize the cancer phenotype are thus a key...

  15. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer

    E-Print Network [OSTI]

    Cai, Long

    Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer, Timothy Anderson6, Norman Gerry7, Joseph Keane4, Marc E Lenburg7 & Jerome S Brody1 Lung cancer smokers with suspicion of lung cancer could be used as a lung cancer biomarker. Using a training set (n

  16. Diagnostic Performance of MRI for Assessing Tumor Response in HER2 Negative Breast Cancer Receiving Neoadjuvant Chemotherapy Is Associated with Molecular Biomarker Profile

    E-Print Network [OSTI]

    2012-01-01T23:59:59.000Z

    systemic treatment of breast cancer. The Breast. 2005; 14:treatments after preoperative chemotherapy for breast cancer:well to the treatment. NAC-treated breast cancers having a

  17. Anti-Tumor Effect in Human Lung Cancer by a Combination Treatment of Novel Histone Deacetylase Inhibitors: SL142 or SL325 and Retinoic Acids

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    novel drugs for the treatment of cancer. Nat Rev Drug Discovepigenetic (and more) treatments for cancer. Nat Rev Cancera promising treatment for cancer. In this study, we

  18. Gene expression profiles in irradiated cancer cells

    SciTech Connect (OSTI)

    Minafra, L.; Bravat, V.; Russo, G.; Ripamonti, M.; Gilardi, M. C. [IBFM CNR - LATO, Cefal, Segrate (Italy)] [IBFM CNR - LATO, Cefal, Segrate (Italy)

    2013-07-26T23:59:59.000Z

    Knowledge of the molecular and genetic mechanisms underlying cellular response to radiation may provide new avenues to develop innovative predictive tests of radiosensitivity of tumours and normal tissues and to improve individual therapy. Nowadays very few studies describe molecular changes induced by hadrontherapy treatments, therefore this field has to be explored and clarified. High-throughput methodologies, such as DNA microarray, allow us to analyse mRNA expression of thousands of genes simultaneously in order to discover new genes and pathways as targets of response to hadrontherapy. Our aim is to elucidate the molecular networks involved in the sensitivity/resistance of cancer cell lines subjected to hadrontherapy treatments with a genomewide approach by using cDNA microarray technology to identify gene expression profiles and candidate genes responsible of differential cellular responses.

  19. Improved mehtods and reagents for pretargeted radioimmunotherapy of cancer

    E-Print Network [OSTI]

    Zajic, Stefan C

    2007-01-01T23:59:59.000Z

    Pretargeted radioimmunotherapy (PRIT) of cancer improves upon conventional radioimmunotherapy (RIT) by decoupling the pharmacokinetics of the targeting agent and the radioisotope. In order to improve upon PRIT, we have ...

  20. The Energy Landscape Analysis of Cancer Mutations in Protein Kinases

    E-Print Network [OSTI]

    Dixit, Anshuman; Verkhivker, Gennady M.

    2011-10-06T23:59:59.000Z

    The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases. In the present ...

  1. Genomics at the Ontario Institute for Cancer Research

    SciTech Connect (OSTI)

    Ali, Johar [Ontario Institute for Cancer Research

    2010-06-02T23:59:59.000Z

    Johar Ali of the Ontario Institute for Cancer Research discusses genomics and next-gen applications at the OICR on June 2, 2010 at the "Sequencing, Finishing, Analysis in the Future" meeting in Santa Fe, NM

  2. Text Mining in Cancer Gene and Pathway Prioritization

    E-Print Network [OSTI]

    Riedlinger, Gregory

    Prioritization of cancer implicated genes has received growing attention as an effective way to reduce wet lab cost by computational analysis that ranks candidate genes according to the likelihood that experimental ...

  3. Cell Death Pathways in Photodynamic Therapy of Cancer

    E-Print Network [OSTI]

    Mroz, Pawel

    Photodynamic therapy (PDT) is an emerging cancer therapy that uses the combination of non-toxic dyes or photosensitizers (PS) and harmless visible light to produce reactive oxygen species and destroy tumors. The PS can be ...

  4. Introduction Prostate cancer has the highest incidence of any malig-

    E-Print Network [OSTI]

    Boyer, Edmond

    -dependent to androgen-independent tumors (2). In the case of metastasis, androgen sup- pression is the leading treatment of cancer-related deaths in men in industrialized countries (1). Besides metas- tasis to bone and lymph

  5. Breast cancer incidence following preeclampsia or gestational hypertension

    E-Print Network [OSTI]

    Wormuth, Jennifer Karen

    1997-01-01T23:59:59.000Z

    A retrospective cohort study was conducted to examine the relationship between preeclampsia or gestational hypertension and subsequent breast cancer in a population of 6,564 pregnant women. Data on the study population came from the Child Health...

  6. All-codon scanning identifies p53 cancer rescue mutations

    E-Print Network [OSTI]

    2010-01-01T23:59:59.000Z

    interactions by alanine-scanning mutagenesis. Science, 244,10.1093/nar/gkq571 All-codon scanning identifies p53 cancer2010 ABSTRACT In vitro scanning mutagenesis strategies are

  7. anal cancer treatment: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    22 23 24 25 Next Page Last Page Topic Index 1 Treatment and outcome of anal cancer in Norway . Open Access Theses and Dissertations Summary: ??Avhandlingen er basert p komplette...

  8. antiangiogenic cancer therapy: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    thyroid cancer, sup 3 sup 2 P for policytemi vera, sup 8 sup 9 Sr and sup 1 sup 5 sup 3 Sm for palliative treatments. There are differences between the hospitals how the...

  9. Cancer Cell of Origin: Spotlight on Luminal Progenitors

    E-Print Network [OSTI]

    Chaffer, Christine L.

    Does basal type breast cancer arise from oncogenic transformation of a basal cell type? In this issue of Cell Stem Cell, Molyneux et al. (2010) investigate the provenance of the basal-type BRCA1 breast carcinoma and come ...

  10. The use of polarized light for skin cancer detecton

    E-Print Network [OSTI]

    DeLaughter, Aimee Hill

    2002-01-01T23:59:59.000Z

    detection system. Presented here is a method for the optical determination of cancerous tissue using polarized light. This thesis describes the development of a polarimetric imaging system including its calibration and testing. In addition, experiments...

  11. Designer Proteins Target Epstein-Barr-Virus-Associated Cancer

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Designer Proteins Target Epstein-Barr-Virus-Associated Cancer Print Immortality is not a good thing for cells, and in fact, cells will destroy themselves in a process called...

  12. Enzyme Structure Provides Insights into Cancer and Aging

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Enzyme Structure Provides Insights into Cancer and Aging Print XPD helicase is an enzyme that unwinds the DNA double helix; it is one component of an essential repair mechanism...

  13. Topo II: An Enzyme Target for Antibacterial and Cancer Drugs

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    Topo II: An Enzyme Target for Antibacterial and Cancer Drugs Print The veil has finally been lifted on an enzyme that is critical to the process of DNA transcription and...

  14. Nested methylation-specific polymerase chain reaction cancer detection method

    DOE Patents [OSTI]

    Belinsky, Steven A. (Albuquerque, NM); Palmisano, William A. (Edgewood, NM)

    2007-05-08T23:59:59.000Z

    A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or "nested" polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.

  15. Technology "Relay Race" Against Cancer | GE Global Research

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    GE Scientists in Technology "Relay Race" Against Cancer Click to email this to a friend (Opens in new window) Share on Facebook (Opens in new window) Click to share (Opens in new...

  16. Tumour microenvironment interactions of small cell lung cancer.

    E-Print Network [OSTI]

    Hodkinson, Philip Simon

    2009-01-01T23:59:59.000Z

    Small cell lung cancer (SCLC) is characterised by rapid growth, early metastatic spread and poor long-term survival. The tumour is initially sensitive to chemotherapy and thus objective response rates are high. Unfortunately, ...

  17. Investigating immune surveillance, tolerance, and therapy in cancer

    E-Print Network [OSTI]

    Cheung, Ann F

    2009-01-01T23:59:59.000Z

    Maximizing the potential of cancer immunotherapy requires model systems that closely recapitulate human disease to study T cell responses to tumor antigens and to test immune therapeutic strategies. Current model systems ...

  18. Systems consequences of amplicon formation in human breast cancer

    E-Print Network [OSTI]

    Inaki, Koichiro

    Chromosomal structural variations play an important role in determining the transcriptional landscape of human breast cancers. To assess the nature of these structural variations, we analyzed eight breast tumor samples ...

  19. antibodies targeting cancer: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    of an NF-B responsive element (pNF-B- Luc) encapsulated in a PRb peptide functionalized stealth targeted systems. In addition, we constructed a novel cancer therapeutic plasmid...

  20. Novel mechanisms of endothelial-epithelial interactions underlying cancer metastasis

    E-Print Network [OSTI]

    Connor, Yamicia Doyasi

    2013-01-01T23:59:59.000Z

    Elucidation of molecular mechanisms underlying metastasis is the final frontier in cancer biology research. Identifying individual pathways in the metastatic cascade could lead to development of metastasis-specific ...

  1. ambulatory cancer patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    confidence interval, 1.005 to 1.420). This J Korean; Soc Coloproctol; Ryung Ah Lee 43 New Knowledge. AT THE UCONN CANCER CENTER, patients can benefit from the latest medical...

  2. anemic cancer patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    confidence interval, 1.005 to 1.420). This J Korean; Soc Coloproctol; Ryung Ah Lee 31 New Knowledge. AT THE UCONN CANCER CENTER, patients can benefit from the latest medical...

  3. admitted cancer patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 Next Page Last Page Topic Index 41 New Knowledge. AT THE UCONN CANCER CENTER, patients can benefit from the latest medical...

  4. advanced cancer patients: Topics by E-print Network

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    confidence interval, 1.005 to 1.420). This J Korean; Soc Coloproctol; Ryung Ah Lee 65 New Knowledge. AT THE UCONN CANCER CENTER, patients can benefit from the latest medical...

  5. Analysis of alterations in the human cancer genome

    E-Print Network [OSTI]

    Carter, Scott L. (Scott Lambert)

    2011-01-01T23:59:59.000Z

    Aneuploidy, an abnormal complement of chromosomes, is present in approximately 90% of human malignancies. Despite over 100 years of research, many questions remain regarding the contribution of aneuploidy to the cancer ...

  6. PRECLINICAL STUDIES Cribrostatin 6 induces death in cancer cells through

    E-Print Network [OSTI]

    Hergenrother, Paul J.

    (sometimes proceeded by bioreductive activation) [24], and others generate cellular reactive oxygen species death through the generation of reactive oxygen species.PRECLINICAL STUDIES Cribrostatin 6 induces death in cancer cells through a reactive oxygen species

  7. Targeting the tight junction : immunotherapy of colon cancer

    E-Print Network [OSTI]

    Ackerman, Margaret E

    2010-01-01T23:59:59.000Z

    A33 is a cell surface glycoprotein of colon epithelium with a long clinical history as a target in antibody-based cancer therapy. Despite being present in normal colon, radio-labeled antibodies against A33 are selectively ...

  8. Selectins Mediate Small Cell Lung Cancer Systemic Metastasis

    E-Print Network [OSTI]

    Heidemann, Franziska

    Metastasis formation is the major reason for the extremely poor prognosis in small cell lung cancer (SCLC) patients. The molecular interaction partners regulating metastasis formation in SCLC are largely unidentified, ...

  9. Application deadline is: Received at the Hutchinson Center 2 weeks prior to the start of each semester

    E-Print Network [OSTI]

    Thomas, Andrew

    the needy in the midcoast for community educational services, including scholarships Pete & Ann Bixler Pete and Ann Bixler have lived on the Maine coast for 40 years. Holding Sc.D. and MA degrees respectively

  10. MicroRNA expression in canine mammary cancer

    E-Print Network [OSTI]

    Boggs, Rene' Michelle

    2008-10-10T23:59:59.000Z

    to act as both tumor suppressors and oncogenes in several different cancers, expression patterns of ten miRNAs (miR-15a, miR-16, miR-17-5p, miR-21, miR-29b, miR-125b, miR-145, miR-155, miR-181b, let-7f) known to be associated with human breast cancer were...

  11. Bone Cancer Rates in Dinosaurs Compared with Modern Vertebrates

    E-Print Network [OSTI]

    L. C. Natarajan; A. L. Melott; B. M. Rothschild; L. D. Martin

    2007-10-16T23:59:59.000Z

    Data on the prevalence of bone cancer in dinosaurs is available from past radiological examination of preserved bones. We statistically test this data for consistency with rates extrapolated from information on bone cancer in modern vertebrates, and find that there is no evidence of a different rate. Thus, this test provides no support for a possible role of ionizing radiation in the K-T extinction event.

  12. RSS Feeds Submit Biological Cancer Therapy There is hope. Learn more about biotherapy treatment options today. CancerCenter.com/CareThatNev

    E-Print Network [OSTI]

    Glaser, Rainer

    RSS Feeds Submit Biological Cancer Therapy There is hope. Learn more about biotherapy treatment options today. CancerCenter.com/CareThatNev O li CNA C tifi ti Q i k d E S h f CNA N i P O li ! Home Earth of pesticides Scientists discover how to improve immune response to cancer at Princess Margaret Hospital Similar

  13. What is the probability that radiation caused a particular cancer

    SciTech Connect (OSTI)

    Voelz, G.L.

    1983-01-01T23:59:59.000Z

    Courts, lawyers, health physicists, physicians, and others are searching for a credible answer to the question posed in the title of this paper. The cases in which the question arises frequently stem from an individual that has cancer and they, or their next-of-kin, are convinced that a past radiation exposure - usually small - is responsible for causing it. An arithmetic expression of this problem is simple: the probability of causation by the radiation dose in question is equal to the risk of cancer from the radiation dose divided by the risk of cancer from all causes. The application of risk factors to this equation is not so simple. It must involve careful evaluation of the reliability of and variations in risk coefficients for development of cancer due to radiation exposure, other carcinogenic agents, and natural causes for the particular individual. Examination of our knowledge of these various factors indicates that a large range in the answers can result due to the variability and imprecision of the data. Nevertheless, the attempts to calculate and the probability that radiation caused the cancer is extremely useful to provide a gross perspective on the probability of causation. It will likely rule in or out a significant number of cases despite the limitations in our understandings of the etiology of cancer and the risks from various factors. For the remaining cases, a thoughtful and educated judgment based on selected data and circumstances of the case will also be needed before the expert can develop and support his opinion.

  14. Carbon Ion Radiotherapy At Gunma University: Currently Indicated Cancer And Estimation Of Need

    SciTech Connect (OSTI)

    Ohno, Tatsuya; Nakano, Takashi; Kanai, Tatsuaki; Yamada, Satoru [Gunma University Heavy Ion Medical Center, Gunma University, 3-39-22 Showa, Maebashi 371-8511 (Japan)

    2011-06-01T23:59:59.000Z

    Carbon ion radiotherapy for the first patient at Gunma University Heavy Ion Medical Center (GHMC) was initiated in March of 2010. The major specifications of the facility were determined based on the experience of clinical treatments at National Institute of Radiological Sciences (NIRS). The currently indicated sites of cancer treatment at GHMC are lung, prostate, head and neck, liver, rectum, bone and soft tissue. In order to evaluate the potential need for treatment in the region including Gunma prefecture and the adjacent 4 prefectures, an estimation model was constructed based on the Japanese cancer registration system, regular structure surveys by the Cancer Societies, and published articles on each cancer type. Carbon ion RT was potentially indicated for 8,085 patients and realistically for 1,527 patients, corresponding to 10% and 2% of the newly diagnosed cancer patients in the region. Prostate cancer (541 patients) followed by lung cancer (436 patients), and liver cancer (313 patients) were the most commonly diagnosed cancers.

  15. Accelerated hypofractionated radiation therapy compared to conventionally fractionated radiation therapy for the treatment of inoperable non-small cell lung cancer

    E-Print Network [OSTI]

    Amini, Arya; Lin, Steven H; Wei, Caimiao; Allen, Pamela; Cox, James D; Komaki, Ritsuko

    2012-01-01T23:59:59.000Z

    of inoperable non-small cell lung cancer. Radiation Oncologystage iii non-small cell lung cancer: randomized phase IIIfactors for non-small cell lung cancer. Lung Cancer 1997,

  16. In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells

    E-Print Network [OSTI]

    2013-01-01T23:59:59.000Z

    P61A6 on non-small cell lung cancer cells. BMC Cancer 2013in mice with K-RAS-induced lung cancer. J Clin Invest 2007,advances in non-small cell lung cancer biology and clinical

  17. BAC-FISH assays delineate complex chromosomal rearrangements in a case of post-Chernobyl childhood thyroid cancer

    E-Print Network [OSTI]

    Kwan, Johnson

    2010-01-01T23:59:59.000Z

    in a case of post-Chernobyl childhood thyroid cancer *D. Thyroid cancer after Chernobyl. Nature 1992;359:21-22. [LN. Thyroid cancer after Chernobyl. Nature [4] Gembicki M,

  18. Expression of Phosphorylated Raf Kinase Inhibitor Protein (pRKIP) is a Predictor of Lung Cancer Survival

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    pRKIP) is a predictor of lung cancer survival Sara Huerta-RKIP and phospho-RKIP in human lung cancer tissue microarrayand in those with early stage lung cancer. Conclusions: This

  19. Evaluation of Irinotecan as a Third- or Fourth-line Treatment for Advanced Non-small Cell Lung Cancer

    E-Print Network [OSTI]

    Keener, James

    2013-01-01T23:59:59.000Z

    Advanced NonSmall-Cell Lung Cancer: An Individual PatientChemotherapy of Non-Small Cell Lung Cancer in the Elderly."Lung Cancer 38, Supplement 3.0 (2002): 67-70. Print. "

  20. Cellular response to 11[beta]-dichloro, a novel aniline mustard-estradienone, in various prostate cancer cell lines

    E-Print Network [OSTI]

    Gonzlez, Francis Hber

    2009-01-01T23:59:59.000Z

    Cancer is a group of diseases characterized by uncontrolled cell growth and abnormal cell cycle and apoptosis regulation. Among the types of cancer, prostate cancer is the leading cause of death in men. Although many ...

  1. Pesticide Container Rinsing 1 Thomas W. Dean, O. Norman Nesheim, and Fred Fishel2

    E-Print Network [OSTI]

    Watson, Craig A.

    .Pour the rinse water back into the sprayer's tank and allow the container to drip-drain for at least 30's label. 2.Allow the formulation to drip-drain from its container into the sprayer's tank for at least 30 Container Rinsing 4.With the container cap placed back on, swirl the water so that all sides are rinsed. 5

  2. Storage Alternatives for Mobile Computers \\Lambda Fred Douglis Ram'on C'aceres

    E-Print Network [OSTI]

    storage technologies offer two alter natives for file storage on mobile computers: magnetic hard disks Laboratories AT&T Bell Laboratories Frans Kaashoek Kai Li Massachusetts Institute of Technology Princeton University Brian Marsh Joshua A. Tauber D.E. Shaw & Co. Massachusetts Institute of Technology To appear

  3. A Novel Multimedia System for Archaeology John Cosmas, Take Itegaki, Damian Green, Edward Grabczewski, Fred Weimer,

    E-Print Network [OSTI]

    Schindler, Konrad

    1 A Novel Multimedia System for Archaeology John Cosmas, Take Itegaki, Damian Green, Edward a set of low-cost multimedia tools for recording, reconstructing, encoding, visualising buildings with a database for proper storage and retrieval. This paper describes the overall concept of this multimedia

  4. SASI Enforcement of Security Policies: A Retrospective Ulfar Erlingsson Fred B. Schneider

    E-Print Network [OSTI]

    Schneider, Fred B.

    is executed. To do its job, a reference monitor must be protected from subversion by the target systems it monitors. Memory pro- tection hardware, which ensures that execution by one pro- gram cannot corrupt the instructions or data of another, is commonly used for this purpose. But placing the reference monitor

  5. SASI Enforcement of Security Policies: A Retrospective # Ulfar Erlingsson Fred B. Schneider

    E-Print Network [OSTI]

    Schneider, Fred B.

    is executed. To do its job, a reference monitor must be protected from subversion by the target systems it monitors. Memory pro tection hardware, which ensures that execution by one pro gram cannot corrupt the instructions or data of another, is commonly used for this purpose. But placing the reference monitor

  6. PIBASE.ligands installation guide. ver 200905 Fred P. Davis, HHMI-JFRC

    E-Print Network [OSTI]

    Eddy, Sean

    SQL interface, a software package is also available that enables a web interface to the database. The database Web interface To install the web interface to the PIBASE.ligands database, you must first have a working PIBASE web server installed. Once you have the PIBASE web interface installed, download the PIBASE

  7. From bogus to gift giver: Fred Trumper's mythopoetic transformation in The Water-Method Man

    E-Print Network [OSTI]

    Headrick, Troy Lee

    1988-01-01T23:59:59.000Z

    . This thesis examines these themes and notes the mythogemic nature of them. More specifically, this thesis focuses on Irving's second novel, The Mater-method san, and claims that the book subverts the hero myth as it is defined by Campbell. Irving subverts... AN INTRODUCTION TO JOHN IRVING AND HIS FICTION: TOWARD AN ART OF "REVERENCE" AND "BLASPHEMY" JOSEPH CAMPBELL'S MONOMYTH AND THE "BLASPHEMY" OF MYTHOPOESIS 16 A BRIEF SURVEY OF MYTHOGEMIC THEMES IN THE IRVING NOVELS 39 IV MULTIQUESTS AND FAII ED RITUALS...

  8. FRED E. WOOD University of California, Davis, Ph.D., Inorganic and Bioinorganic Chemistry, 1984

    E-Print Network [OSTI]

    Amin, S. Massoud

    housing and residential education; Student health and psychological services; Recreation (intramurals and leadership for the following areas: Enrollment services (admissions, financial aid, registrar and student information system); Division I Intercollegiate Athletics; Academic support services (orientation, learning

  9. U.S. DEPARTMENT OF COMMERCE Fred erick B. Dent, Secretary

    E-Print Network [OSTI]

    , and Tanner Crabs; Chionoecetes bairdi, Robert M. Meyer 17 A Survey of Giant Clams, Tridacnidae, on Helen Reef on Molting Tanner Crabs, Chionoecetes bairdi, John F. Karinen and Stanley D. Rice Departments 38 NOAA

  10. Agriculture and Natural Resources Fred L. Poston, Dean and Special Advisor to the President

    E-Print Network [OSTI]

    Liu, Taosheng

    -Elmoore, Dean International Studies and Programs Steven D. Hanson, Interim Dean National Superconducting

  11. WAIF: Web of Asynchronous Information Filters # Dag Johansen, Robbert van Renesse, and Fred B. Schneider

    E-Print Network [OSTI]

    Schneider, Fred B.

    work well only for information that is relatively static and remains relevant for long intervals. More to rate the news stream provided by each publisher. The paradigm can be likened to a sound­mixer control panel, with a slide control for each subscription; the mixer panel is part of our WAIF browser

  12. ARPA-E Announces 2012 Energy Innovation Summit Featuring Bill Gates, Fred

    Energy Savers [EERE]

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative Fuels Data Center Home Page onYou are now leaving Energy.gov You are now leaving Energy.gov You are being directed off Energy.gov. Are you0 ARRA Newsletters 2010 ARRAA LiquidAL2010-03.pdfAMOSmith and Lee Scott |

  13. A video interview with Fred Dylla, AIP CEO (SPIE Newsroom) | Jefferson Lab

    Broader source: All U.S. Department of Energy (DOE) Office Webpages (Extended Search)

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level: National5Sales for4,645U.S. DOE Office of ScienceandMesa del(ANL-IN-03-032) -Less isNFebruaryOctober 2,generationPhysics

  14. Fred N. Mortensen, 2004 | U.S. DOE Office of Science (SC)

    Office of Science (SC) Website

    AFDC Printable Version Share this resource Send a link to EERE: Alternative Fuels Data Center Home Page to someone by E-mail Share EERE: Alternative Fuels Data Center Home Page on Facebook Tweet about EERE: Alternative Fuels Data Center Home Page on Twitter Bookmark EERE: Alternative1 First Use of Energy for All Purposes (Fuel and Nonfuel), 2002; Level:Energy: Grid Integration Redefining What'sis Taking Over OurThe Iron4(SC) MappingOctober 12,U.S. DOE OfficeU.S. DOEFred N. Mortensen,

  15. Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells

    SciTech Connect (OSTI)

    Hamada, Shin [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)] [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan); Masamune, Atsushi, E-mail: amasamune@med.tohoku.ac.jp [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)] [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan); Takikawa, Tetsuya; Suzuki, Noriaki; Kikuta, Kazuhiro; Hirota, Morihisa [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)] [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan); Hamada, Hirofumi [Laboratory of Oncology, Department of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji (Japan)] [Laboratory of Oncology, Department of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji (Japan); Kobune, Masayoshi [Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo (Japan)] [Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo (Japan); Satoh, Kennichi [Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori (Japan)] [Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori (Japan); Shimosegawa, Tooru [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)] [Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai (Japan)

    2012-05-04T23:59:59.000Z

    Highlights: Black-Right-Pointing-Pointer Pancreatic stellate cells (PSCs) promote the progression of pancreatic cancer. Black-Right-Pointing-Pointer Pancreatic cancer cells co-cultured with PSCs showed enhanced spheroid formation. Black-Right-Pointing-Pointer Expression of stem cell-related genes ABCG2, Nestin and LIN28 was increased. Black-Right-Pointing-Pointer Co-injection of PSCs enhanced tumorigenicity of pancreatic cancer cells in vivo. Black-Right-Pointing-Pointer This study suggested a novel role of PSCs as a part of the cancer stem cell niche. -- Abstract: The interaction between pancreatic cancer cells and pancreatic stellate cells (PSCs), a major profibrogenic cell type in the pancreas, is receiving increasing attention. There is accumulating evidence that PSCs promote the progression of pancreatic cancer by increasing cancer cell proliferation and invasion as well as by protecting them from radiation- and gemcitabine-induced apoptosis. Recent studies have identified that a portion of cancer cells, called 'cancer stem cells', within the entire cancer tissue harbor highly tumorigenic and chemo-resistant phenotypes, which lead to the recurrence after surgery or re-growth of the tumor. The mechanisms that maintain the 'stemness' of these cells remain largely unknown. We hypothesized that PSCs might enhance the cancer stem cell-like phenotypes in pancreatic cancer cells. Indirect co-culture of pancreatic cancer cells with PSCs enhanced the spheroid-forming ability of cancer cells and induced the expression of cancer stem cell-related genes ABCG2, Nestin and LIN28. In addition, co-injection of PSCs enhanced tumorigenicity of pancreatic cancer cells in vivo. These results suggested a novel role of PSCs as a part of the cancer stem cell niche.

  16. Cancer Systems Biology Dana Faratian, James L. Bown, V. Anne Smith, Simon P. Langdon,

    E-Print Network [OSTI]

    Smith, V Anne

    245 Chapter 12 Cancer Systems Biology Dana Faratian, James L. Bown, V. Anne Smith, Simon P. Langdon+Business Media, LLC 2010 #12;246 Faratian et al. While cancer can arise from any cell in the body, the commonest

  17. KISS1 and Its G Protein-Coupled Receptor (GPR54) in Cancer Progression and Metastasis

    E-Print Network [OSTI]

    Cho, Sunggook Gook

    2012-02-14T23:59:59.000Z

    in cancer progression is still unclear. This study demonstrates that an autocrine GPR54 signaling regulates breast cancer progression and metastasis. When MMTV-PyMT mice were crossed with Gpr54 heterozygous mice, Gpr54 heterozygosity attenuated Py...

  18. Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery

    E-Print Network [OSTI]

    Zhang, GuangJun

    The identification of cancer drivers is a major goal of current cancer research. Finding driver genes within large chromosomal events is especially challenging because such alterations encompass many genes. Previously, we ...

  19. A general method for studying autocrine signaling and its impact on cancer cell growth

    E-Print Network [OSTI]

    Sampattavanich, Somponnat

    2011-01-01T23:59:59.000Z

    Autocrine signaling plays essential roles in providing self-sustaining growth signals to cancer cells. Since the introduction of the autocrine hypothesis in 1980s, the contribution of autocrine signaling in cancer medicine ...

  20. Mechanisms of Action of Metformin as an Anti-cancer Agent

    E-Print Network [OSTI]

    Ramachandran Nair Vasanthakum, Vijayalekshmi

    2014-08-13T23:59:59.000Z

    Cancer is the second leading cause of death worldwide and epidemiological studies suggest the association of diabetes mellitus with an enhanced risk for multiple cancers. Metformin (1,1-dimethylbiguanide hydrochloride) is the most widely prescribed...

  1. Molecular biomarker discovery and physiological assessment of skeletal muscle in cancer cachexia

    E-Print Network [OSTI]

    Stephens, Nathan Andrew

    2014-07-05T23:59:59.000Z

    Cachexia affects up to two thirds of all cancer patients with progressive disease. It is a syndrome characterised by weight-loss, anorexia, fatigue, asthenia, peripheral oedema, and is responsible for around 20% of cancer ...

  2. Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?

    E-Print Network [OSTI]

    2011-01-01T23:59:59.000Z

    ascorbic acid to prevent and treat cancer-associated sepsis?value of i.v. AA in cancer treat- ment is controversial. Inpatients to prevent/treat SIRS. There is an additional

  3. Pomegranate Juice and Pomegranate Derived Natural Products as Alternative Treatment for Cancer Progression and Metastasis

    E-Print Network [OSTI]

    Wang, Lei

    2013-01-01T23:59:59.000Z

    and the G2-M checkpoint in MDA-MB-231 breast cancer cells.MCF-7) and ER negative (MB-MDA-231) breast cancer cell linespomegranate treatment than MB-MDA-231 cells. The seed oil

  4. Nuclear Factor I/B is an Oncogene in Small Cell Lung Cancer

    E-Print Network [OSTI]

    Dooley, Alison L.

    Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. ...

  5. Mouse models of lung cancer : understanding the molecular and cellular basis of lung tumorigenesis

    E-Print Network [OSTI]

    Jackson, Erica L. (Erica Lynn), 1973-

    2003-01-01T23:59:59.000Z

    Lung cancer is the leading cause of cancer deaths worldwide. Patients are typically diagnosed with advanced disease and have a high fatality:case ratio. Despite its prevalence, the identity of the cell of origin, precursor ...

  6. Socioeconomic status and prostate cancer incidence and mortality rates among the diverse population of California

    E-Print Network [OSTI]

    2009-01-01T23:59:59.000Z

    MN, Smith E, Siadaty M, Hauck FR, Pickle LW (2006) Spatial analysis of prostate cancer incidence and race in Virginia,

  7. Regulation of E2F-1 gene expression in human breast cancer cells

    E-Print Network [OSTI]

    Ngwenya, Sharon Khethiwe

    2005-08-29T23:59:59.000Z

    among women in the Western world, second to lung cancer. And in 2003, approximately 39,800 women died as a result of breast cancer (10). The reported incidence of breast cancer has risen during recent years due to the increase of mammography... likely to be initiated, i.e. early adulthood and reproductive years, and increased breast cancer risk (17). However, other studies have reported that estrogens are able to induce direct and indirect free radical-mediated DNA damage, genetic...

  8. Ell3 stimulates proliferation, drug resistance, and cancer stem cell properties of breast cancer cells via a MEK/ERK-dependent signaling pathway

    SciTech Connect (OSTI)

    Ahn, Hee-Jin [Department of Biomedical Science, College of Life Science, CHA University, Seoul (Korea, Republic of)] [Department of Biomedical Science, College of Life Science, CHA University, Seoul (Korea, Republic of); Kim, Gwangil [Department of Pathology, CHA Bundang Medical Center, CHA University, Seoul (Korea, Republic of)] [Department of Pathology, CHA Bundang Medical Center, CHA University, Seoul (Korea, Republic of); Park, Kyung-Soon, E-mail: kspark@cha.ac.kr [Department of Biomedical Science, College of Life Science, CHA University, Seoul (Korea, Republic of)] [Department of Biomedical Science, College of Life Science, CHA University, Seoul (Korea, Republic of)

    2013-08-09T23:59:59.000Z

    Highlights: Ell3 enhances proliferation and drug resistance of breast cancer cell lines. Ell3 is related to the cancer stem cell characteristics of breast cancer cell lines. Ell3 enhances oncogenicity of breast cancer through the ERK1/2 signaling pathway. -- Abstract: Ell3 is a RNA polymerase II transcription elongation factor that is enriched in testis. The C-terminal domain of Ell3 shows strong similarities to that of Ell (eleven?nineteen lysine-rich leukemia gene), which acts as a negative regulator of p53 and regulates cell proliferation and survival. Recent studies in our laboratory showed that Ell3 induces the differentiation of mouse embryonic stem cells by protecting differentiating cells from apoptosis via the promotion of p53 degradation. In this study, we evaluated the function of Ell3 in breast cancer cell lines. MCF-7 cell lines overexpressing Ell3 were used to examine cell proliferation and cancer stem cell properties. Ectopic expression of Ell3 in breast cancer cell lines induces proliferation and 5-FU resistance. In addition, Ell3 expression increases the cancer stem cell population, which is characterized by CD44 (+) or ALDH1 (+) cells. Mammosphere-forming potential and migration ability were also increased upon Ell3 expression in breast cancer cell lines. Through biochemical and molecular biological analyses, we showed that Ell3 regulates proliferation, cancer stem cell properties and drug resistance in breast cancer cell lines partly through the MEK?extracellular signal-regulated kinase signaling pathway. Murine xenograft experiments showed that Ell3 expression promotes tumorigenesis in vivo. These results suggest that Ell3 may play a critical role in promoting oncogenesis in breast cancer by regulating cell proliferation and cancer stem cell properties via the ERK1/2 signaling pathway.

  9. Information Needs of Young Breast Cancer Patients with Early Menopause Symptoms Alisha D. Allison1

    E-Print Network [OSTI]

    Zhou, Yaoqi

    and Janet S. Carpenter1 Department of Adult Health, IU School of Nursing1 Breast cancer treatments can cause to the study, the women were asked to provide demographic and cancer treatment information and complete a semi cancer patients will need before treatment decisions are made. These findings will help medical

  10. ADVANCING A HEALTHIER WISCONSIN ENDOWMENT: RESEARCH AND EDUCATION PROGRAM Pancreatic Cancer Research Program

    E-Print Network [OSTI]

    cancer biology suggest that a single treatment approach for this heterogeneous and biologically complex cancer is not ideal. In the future, the best treatments may be determined by the molecular determinantsADVANCING A HEALTHIER WISCONSIN ENDOWMENT: RESEARCH AND EDUCATION PROGRAM Pancreatic Cancer

  11. ANTI-ANGIOGENIC THERAPY IN CANCER TREATMENT AS AN OPTIMAL CONTROL PROBLEM

    E-Print Network [OSTI]

    Schaettler, Heinz

    ANTI-ANGIOGENIC THERAPY IN CANCER TREATMENT AS AN OPTIMAL CONTROL PROBLEM URSZULA LEDZEWICZ AND HEINZ SCHATTLER Abstract. Anti-angiogenic therapy is a novel treatment approach in cancer therapy. Key words. optimal control, geometric methods, cancer treatment, anti-angiogenic therapy AMS subject

  12. Questions and Answers About Kidney CancerCENTERS FOR DISEASE CONTROL AND PREVENTION

    E-Print Network [OSTI]

    of the tumor What are the treatments for kidney cancer? There are several treatment options for kidney cancer. They are usually used in combination. The treatment plan chosen is based on the type and stage of the cancer, as well as the age and general health of the patient. The treatments are: Surgery - includes

  13. Cancer gene therapy with oncolytic adenoviruses K. Guse,A. Hemminki

    E-Print Network [OSTI]

    Hemminki, Akseli

    , Helsinki, Finland Summary Metastatic cancer remains difficult to treat effectively and treatments therapy hold promise for the treatment of various tu- mor types. Among the most promising cancer gene efficacy needs to be improved to make oncolytic adenoviruses a viable treatment alterna- tive for cancer

  14. Therapeutic and diagnostic applications of dendrimers for cancer treatment Jesse B. Wolinsky, Mark W. Grinstaff

    E-Print Network [OSTI]

    Therapeutic and diagnostic applications of dendrimers for cancer treatment Jesse B. Wolinsky, Mark and diagnostic purposes for the treatment of cancer, including advances in the delivery of anti.V. Keywords: Dendrimer; Local Therapy; Nanoparticle; Cancer Treatment; Drug-conjugates; Drug Delivery Contents

  15. Oncolytic Adenoviruses for the Treatment of Human Cancer: Focus on Translational and Clinical Data

    E-Print Network [OSTI]

    Hemminki, Akseli

    Oncolytic Adenoviruses for the Treatment of Human Cancer: Focus on Translational and Clinical Data results of cancer treatment have improved steadily, metastatic solid tumors can be cured only rarely of more sensitive diagnostic methods and new treatment modalities. However, cancer is still usually incur

  16. Nano-Sensor and Circuit Design for Anti-Cancer Drug Detection

    E-Print Network [OSTI]

    De Micheli, Giovanni

    in the case of some pharmacological treatments based on drug regimens, such as anti-cancer drug therapies [2]. Etoposide is a widely used anti-cancer drug, administered for the treatment of many kinds of tumours [3, 4Nano-Sensor and Circuit Design for Anti-Cancer Drug Detection S. Sara Ghoreishizadeh, Camilla Baj

  17. Simulating the Hallmarks of Cancer Robert G. Abbott Sandia National Laboratories

    E-Print Network [OSTI]

    Forrest, Stephanie

    controlled and longevity climbs in developing nations. Although the need for better cancer treatment slow, and treatments are generally limited to specific forms of the disease. Most cancer researchSimulating the Hallmarks of Cancer Robert G. Abbott Sandia National Laboratories P.O. Box 5800

  18. DCA and DMAPT as Radiosensitizing Drugs in the Treatment of Pancreatic Cancer Ana Cavazos (Marc Mendonca),

    E-Print Network [OSTI]

    Zhou, Yaoqi

    DCA and DMAPT as Radiosensitizing Drugs in the Treatment of Pancreatic Cancer Ana Cavazos (Marc and invasiveness. Recurrence is thought to be due in part to the resistance of pancreatic cancer cells. Treatment cancer cells (MIA PACA2) being exposed to DMAPT, DCA, and dual treatment, with or without radiation

  19. Compact Fuzzy Rules Induction and Feature Extraction Using SVM with Particle Swarms for Breast Cancer Treatments

    E-Print Network [OSTI]

    Aickelin, Uwe

    Cancer Treatments Shang-Ming Zhou, Robert I. John, Xiao-Ying Wang, Jonathan M. Garibaldi, and Ian O. Ellis Abstract-- Developing a treatment plan for breast cancer patient is a very complex process. It is widely accepted that developing a treatment plan for a breast cancer patient is a very complex process

  20. A Mathematical Model of Gene Therapy for the Treatment of Cancer

    E-Print Network [OSTI]

    Kirschner, Denise

    A Mathematical Model of Gene Therapy for the Treatment of Cancer Alexei Tsygvintsev1, Simeone to the mainstream population. Unfortunately, treatment of cancer is still in its infancy, although there are some we will focus solely on ge- netic issues related to cancer so that we can explore a new treatment